Skip to content

Commit

Permalink
update readme details to match current software spec
Browse files Browse the repository at this point in the history
  • Loading branch information
yutanagano committed Jan 26, 2025
1 parent b15ac97 commit c9d817a
Showing 1 changed file with 2 additions and 2 deletions.
4 changes: 2 additions & 2 deletions README.md
Original file line number Diff line number Diff line change
Expand Up @@ -18,14 +18,14 @@
|---|
| Graphical abstract. Traditional protein language models that are trained purely on masked-language modelling underperform sequence alignment models on TCR specificity prediction. In contrast, our model SCEPTR is jointly trained on masked-language modelling and contrastive learning, allowing it to outperform other language models as well as the best sequence alignment models to achieve state-of-the-art performance. |

**SCEPTR** (**S**imple **C**ontrastive **E**mbedding of the **P**rimary sequence of **T** cell **R**eceptors) is a small, fast, and accurate TCR representation model that can be used for alignment-free TCR analysis, including for TCR-pMHC interaction prediction and TCR clustering (metaclonotype discovery).
**SCEPTR** (**S**imple **C**ontrastive **E**mbedding of the **P**rimary sequence of **T** cell **R**eceptors) is a small, fast, and informative TCR representation model that can be used for alignment-free TCR analysis, including for TCR-pMHC interaction prediction and TCR clustering (metaclonotype discovery).
Our [manuscript](https://www.cell.com/cell-systems/fulltext/S2405-4712(24)00369-7) demonstrates that SCEPTR can be used for few-shot TCR specificity prediction with improved accuracy over previous methods.

SCEPTR is a BERT-like transformer-based neural network implemented in [Pytorch](https://pytorch.org).
With the default model providing best-in-class performance with only 153,108 parameters (typical protein language models have tens or hundreds of millions), SCEPTR runs fast- even on a CPU!
And if your computer does have a [CUDA-enabled GPU](https://en.wikipedia.org/wiki/CUDA), the sceptr package will automatically detect and use it, giving you blazingly fast performance without the hassle.

sceptr's API exposes three intuitive functions: `calc_vector_representations`, `calc_cdist_matrix`, and `calc_pdist_vector`- and it's all you need to make full use of the SCEPTR models.
sceptr's API exposes four intuitive functions: `calc_cdist_matrix`, `calc_pdist_vector`, `calc_vector_representations`, and `calc_residue_representations` -- and it's all you need to make full use of the SCEPTR models.
What's even better is that they are fully compliant with [pyrepseq](https://pyrepseq.readthedocs.io)'s [tcr_metric](https://pyrepseq.readthedocs.io/en/latest/api.html#pyrepseq.metric.tcr_metric.TcrMetric) API, so sceptr will fit snugly into the rest of your repertoire analysis workflow.

## Installation
Expand Down

0 comments on commit c9d817a

Please sign in to comment.