02-sequence_databases/04-programming_for_web_blast.html

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.glyphicon-triangle-bottom:before {
  content: "\e252";
}
.glyphicon-triangle-top:before {
  content: "\e253";
}
.glyphicon-console:before {
  content: "\e254";
}
.glyphicon-superscript:before {
  content: "\e255";
}
.glyphicon-subscript:before {
  content: "\e256";
}
.glyphicon-menu-left:before {
  content: "\e257";
}
.glyphicon-menu-right:before {
  content: "\e258";
}
.glyphicon-menu-down:before {
  content: "\e259";
}
.glyphicon-menu-up:before {
  content: "\e260";
}
* {
  -webkit-box-sizing: border-box;
  -moz-box-sizing: border-box;
  box-sizing: border-box;
}
*:before,
*:after {
  -webkit-box-sizing: border-box;
  -moz-box-sizing: border-box;
  box-sizing: border-box;
}
html {
  font-size: 10px;
  -webkit-tap-highlight-color: rgba(0, 0, 0, 0);
}
body {
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
  font-size: 13px;
  line-height: 1.42857143;
  color: #000;
  background-color: #fff;
}
input,
button,
select,
textarea {
  font-family: inherit;
  font-size: inherit;
  line-height: inherit;
}
a {
  color: #337ab7;
  text-decoration: none;
}
a:hover,
a:focus {
  color: #23527c;
  text-decoration: underline;
}
a:focus {
  outline: 5px auto -webkit-focus-ring-color;
  outline-offset: -2px;
}
figure {
  margin: 0;
}
img {
  vertical-align: middle;
}
.img-responsive,
.thumbnail > img,
.thumbnail a > img,
.carousel-inner > .item > img,
.carousel-inner > .item > a > img {
  display: block;
  max-width: 100%;
  height: auto;
}
.img-rounded {
  border-radius: 3px;
}
.img-thumbnail {
  padding: 4px;
  line-height: 1.42857143;
  background-color: #fff;
  border: 1px solid #ddd;
  border-radius: 2px;
  -webkit-transition: all 0.2s ease-in-out;
  -o-transition: all 0.2s ease-in-out;
  transition: all 0.2s ease-in-out;
  display: inline-block;
  max-width: 100%;
  height: auto;
}
.img-circle {
  border-radius: 50%;
}
hr {
  margin-top: 18px;
  margin-bottom: 18px;
  border: 0;
  border-top: 1px solid #eeeeee;
}
.sr-only {
  position: absolute;
  width: 1px;
  height: 1px;
  margin: -1px;
  padding: 0;
  overflow: hidden;
  clip: rect(0, 0, 0, 0);
  border: 0;
}
.sr-only-focusable:active,
.sr-only-focusable:focus {
  position: static;
  width: auto;
  height: auto;
  margin: 0;
  overflow: visible;
  clip: auto;
}
[role="button"] {
  cursor: pointer;
}
h1,
h2,
h3,
h4,
h5,
h6,
.h1,
.h2,
.h3,
.h4,
.h5,
.h6 {
  font-family: inherit;
  font-weight: 500;
  line-height: 1.1;
  color: inherit;
}
h1 small,
h2 small,
h3 small,
h4 small,
h5 small,
h6 small,
.h1 small,
.h2 small,
.h3 small,
.h4 small,
.h5 small,
.h6 small,
h1 .small,
h2 .small,
h3 .small,
h4 .small,
h5 .small,
h6 .small,
.h1 .small,
.h2 .small,
.h3 .small,
.h4 .small,
.h5 .small,
.h6 .small {
  font-weight: normal;
  line-height: 1;
  color: #777777;
}
h1,
.h1,
h2,
.h2,
h3,
.h3 {
  margin-top: 18px;
  margin-bottom: 9px;
}
h1 small,
.h1 small,
h2 small,
.h2 small,
h3 small,
.h3 small,
h1 .small,
.h1 .small,
h2 .small,
.h2 .small,
h3 .small,
.h3 .small {
  font-size: 65%;
}
h4,
.h4,
h5,
.h5,
h6,
.h6 {
  margin-top: 9px;
  margin-bottom: 9px;
}
h4 small,
.h4 small,
h5 small,
.h5 small,
h6 small,
.h6 small,
h4 .small,
.h4 .small,
h5 .small,
.h5 .small,
h6 .small,
.h6 .small {
  font-size: 75%;
}
h1,
.h1 {
  font-size: 33px;
}
h2,
.h2 {
  font-size: 27px;
}
h3,
.h3 {
  font-size: 23px;
}
h4,
.h4 {
  font-size: 17px;
}
h5,
.h5 {
  font-size: 13px;
}
h6,
.h6 {
  font-size: 12px;
}
p {
  margin: 0 0 9px;
}
.lead {
  margin-bottom: 18px;
  font-size: 14px;
  font-weight: 300;
  line-height: 1.4;
}
@media (min-width: 768px) {
  .lead {
    font-size: 19.5px;
  }
}
small,
.small {
  font-size: 92%;
}
mark,
.mark {
  background-color: #fcf8e3;
  padding: .2em;
}
.text-left {
  text-align: left;
}
.text-right {
  text-align: right;
}
.text-center {
  text-align: center;
}
.text-justify {
  text-align: justify;
}
.text-nowrap {
  white-space: nowrap;
}
.text-lowercase {
  text-transform: lowercase;
}
.text-uppercase {
  text-transform: uppercase;
}
.text-capitalize {
  text-transform: capitalize;
}
.text-muted {
  color: #777777;
}
.text-primary {
  color: #337ab7;
}
a.text-primary:hover,
a.text-primary:focus {
  color: #286090;
}
.text-success {
  color: #3c763d;
}
a.text-success:hover,
a.text-success:focus {
  color: #2b542c;
}
.text-info {
  color: #31708f;
}
a.text-info:hover,
a.text-info:focus {
  color: #245269;
}
.text-warning {
  color: #8a6d3b;
}
a.text-warning:hover,
a.text-warning:focus {
  color: #66512c;
}
.text-danger {
  color: #a94442;
}
a.text-danger:hover,
a.text-danger:focus {
  color: #843534;
}
.bg-primary {
  color: #fff;
  background-color: #337ab7;
}
a.bg-primary:hover,
a.bg-primary:focus {
  background-color: #286090;
}
.bg-success {
  background-color: #dff0d8;
}
a.bg-success:hover,
a.bg-success:focus {
  background-color: #c1e2b3;
}
.bg-info {
  background-color: #d9edf7;
}
a.bg-info:hover,
a.bg-info:focus {
  background-color: #afd9ee;
}
.bg-warning {
  background-color: #fcf8e3;
}
a.bg-warning:hover,
a.bg-warning:focus {
  background-color: #f7ecb5;
}
.bg-danger {
  background-color: #f2dede;
}
a.bg-danger:hover,
a.bg-danger:focus {
  background-color: #e4b9b9;
}
.page-header {
  padding-bottom: 8px;
  margin: 36px 0 18px;
  border-bottom: 1px solid #eeeeee;
}
ul,
ol {
  margin-top: 0;
  margin-bottom: 9px;
}
ul ul,
ol ul,
ul ol,
ol ol {
  margin-bottom: 0;
}
.list-unstyled {
  padding-left: 0;
  list-style: none;
}
.list-inline {
  padding-left: 0;
  list-style: none;
  margin-left: -5px;
}
.list-inline > li {
  display: inline-block;
  padding-left: 5px;
  padding-right: 5px;
}
dl {
  margin-top: 0;
  margin-bottom: 18px;
}
dt,
dd {
  line-height: 1.42857143;
}
dt {
  font-weight: bold;
}
dd {
  margin-left: 0;
}
@media (min-width: 541px) {
  .dl-horizontal dt {
    float: left;
    width: 160px;
    clear: left;
    text-align: right;
    overflow: hidden;
    text-overflow: ellipsis;
    white-space: nowrap;
  }
  .dl-horizontal dd {
    margin-left: 180px;
  }
}
abbr[title],
abbr[data-original-title] {
  cursor: help;
  border-bottom: 1px dotted #777777;
}
.initialism {
  font-size: 90%;
  text-transform: uppercase;
}
blockquote {
  padding: 9px 18px;
  margin: 0 0 18px;
  font-size: inherit;
  border-left: 5px solid #eeeeee;
}
blockquote p:last-child,
blockquote ul:last-child,
blockquote ol:last-child {
  margin-bottom: 0;
}
blockquote footer,
blockquote small,
blockquote .small {
  display: block;
  font-size: 80%;
  line-height: 1.42857143;
  color: #777777;
}
blockquote footer:before,
blockquote small:before,
blockquote .small:before {
  content: '\2014 \00A0';
}
.blockquote-reverse,
blockquote.pull-right {
  padding-right: 15px;
  padding-left: 0;
  border-right: 5px solid #eeeeee;
  border-left: 0;
  text-align: right;
}
.blockquote-reverse footer:before,
blockquote.pull-right footer:before,
.blockquote-reverse small:before,
blockquote.pull-right small:before,
.blockquote-reverse .small:before,
blockquote.pull-right .small:before {
  content: '';
}
.blockquote-reverse footer:after,
blockquote.pull-right footer:after,
.blockquote-reverse small:after,
blockquote.pull-right small:after,
.blockquote-reverse .small:after,
blockquote.pull-right .small:after {
  content: '\00A0 \2014';
}
address {
  margin-bottom: 18px;
  font-style: normal;
  line-height: 1.42857143;
}
code,
kbd,
pre,
samp {
  font-family: monospace;
}
code {
  padding: 2px 4px;
  font-size: 90%;
  color: #c7254e;
  background-color: #f9f2f4;
  border-radius: 2px;
}
kbd {
  padding: 2px 4px;
  font-size: 90%;
  color: #888;
  background-color: transparent;
  border-radius: 1px;
  box-shadow: inset 0 -1px 0 rgba(0, 0, 0, 0.25);
}
kbd kbd {
  padding: 0;
  font-size: 100%;
  font-weight: bold;
  box-shadow: none;
}
pre {
  display: block;
  padding: 8.5px;
  margin: 0 0 9px;
  font-size: 12px;
  line-height: 1.42857143;
  word-break: break-all;
  word-wrap: break-word;
  color: #333333;
  background-color: #f5f5f5;
  border: 1px solid #ccc;
  border-radius: 2px;
}
pre code {
  padding: 0;
  font-size: inherit;
  color: inherit;
  white-space: pre-wrap;
  background-color: transparent;
  border-radius: 0;
}
.pre-scrollable {
  max-height: 340px;
  overflow-y: scroll;
}
.container {
  margin-right: auto;
  margin-left: auto;
  padding-left: 0px;
  padding-right: 0px;
}
@media (min-width: 768px) {
  .container {
    width: 768px;
  }
}
@media (min-width: 992px) {
  .container {
    width: 940px;
  }
}
@media (min-width: 1200px) {
  .container {
    width: 1140px;
  }
}
.container-fluid {
  margin-right: auto;
  margin-left: auto;
  padding-left: 0px;
  padding-right: 0px;
}
.row {
  margin-left: 0px;
  margin-right: 0px;
}
.col-xs-1, .col-sm-1, .col-md-1, .col-lg-1, .col-xs-2, .col-sm-2, .col-md-2, .col-lg-2, .col-xs-3, .col-sm-3, .col-md-3, .col-lg-3, .col-xs-4, .col-sm-4, .col-md-4, .col-lg-4, .col-xs-5, .col-sm-5, .col-md-5, .col-lg-5, .col-xs-6, .col-sm-6, .col-md-6, .col-lg-6, .col-xs-7, .col-sm-7, .col-md-7, .col-lg-7, .col-xs-8, .col-sm-8, .col-md-8, .col-lg-8, .col-xs-9, .col-sm-9, .col-md-9, .col-lg-9, .col-xs-10, .col-sm-10, .col-md-10, .col-lg-10, .col-xs-11, .col-sm-11, .col-md-11, .col-lg-11, .col-xs-12, .col-sm-12, .col-md-12, .col-lg-12 {
  position: relative;
  min-height: 1px;
  padding-left: 0px;
  padding-right: 0px;
}
.col-xs-1, .col-xs-2, .col-xs-3, .col-xs-4, .col-xs-5, .col-xs-6, .col-xs-7, .col-xs-8, .col-xs-9, .col-xs-10, .col-xs-11, .col-xs-12 {
  float: left;
}
.col-xs-12 {
  width: 100%;
}
.col-xs-11 {
  width: 91.66666667%;
}
.col-xs-10 {
  width: 83.33333333%;
}
.col-xs-9 {
  width: 75%;
}
.col-xs-8 {
  width: 66.66666667%;
}
.col-xs-7 {
  width: 58.33333333%;
}
.col-xs-6 {
  width: 50%;
}
.col-xs-5 {
  width: 41.66666667%;
}
.col-xs-4 {
  width: 33.33333333%;
}
.col-xs-3 {
  width: 25%;
}
.col-xs-2 {
  width: 16.66666667%;
}
.col-xs-1 {
  width: 8.33333333%;
}
.col-xs-pull-12 {
  right: 100%;
}
.col-xs-pull-11 {
  right: 91.66666667%;
}
.col-xs-pull-10 {
  right: 83.33333333%;
}
.col-xs-pull-9 {
  right: 75%;
}
.col-xs-pull-8 {
  right: 66.66666667%;
}
.col-xs-pull-7 {
  right: 58.33333333%;
}
.col-xs-pull-6 {
  right: 50%;
}
.col-xs-pull-5 {
  right: 41.66666667%;
}
.col-xs-pull-4 {
  right: 33.33333333%;
}
.col-xs-pull-3 {
  right: 25%;
}
.col-xs-pull-2 {
  right: 16.66666667%;
}
.col-xs-pull-1 {
  right: 8.33333333%;
}
.col-xs-pull-0 {
  right: auto;
}
.col-xs-push-12 {
  left: 100%;
}
.col-xs-push-11 {
  left: 91.66666667%;
}
.col-xs-push-10 {
  left: 83.33333333%;
}
.col-xs-push-9 {
  left: 75%;
}
.col-xs-push-8 {
  left: 66.66666667%;
}
.col-xs-push-7 {
  left: 58.33333333%;
}
.col-xs-push-6 {
  left: 50%;
}
.col-xs-push-5 {
  left: 41.66666667%;
}
.col-xs-push-4 {
  left: 33.33333333%;
}
.col-xs-push-3 {
  left: 25%;
}
.col-xs-push-2 {
  left: 16.66666667%;
}
.col-xs-push-1 {
  left: 8.33333333%;
}
.col-xs-push-0 {
  left: auto;
}
.col-xs-offset-12 {
  margin-left: 100%;
}
.col-xs-offset-11 {
  margin-left: 91.66666667%;
}
.col-xs-offset-10 {
  margin-left: 83.33333333%;
}
.col-xs-offset-9 {
  margin-left: 75%;
}
.col-xs-offset-8 {
  margin-left: 66.66666667%;
}
.col-xs-offset-7 {
  margin-left: 58.33333333%;
}
.col-xs-offset-6 {
  margin-left: 50%;
}
.col-xs-offset-5 {
  margin-left: 41.66666667%;
}
.col-xs-offset-4 {
  margin-left: 33.33333333%;
}
.col-xs-offset-3 {
  margin-left: 25%;
}
.col-xs-offset-2 {
  margin-left: 16.66666667%;
}
.col-xs-offset-1 {
  margin-left: 8.33333333%;
}
.col-xs-offset-0 {
  margin-left: 0%;
}
@media (min-width: 768px) {
  .col-sm-1, .col-sm-2, .col-sm-3, .col-sm-4, .col-sm-5, .col-sm-6, .col-sm-7, .col-sm-8, .col-sm-9, .col-sm-10, .col-sm-11, .col-sm-12 {
    float: left;
  }
  .col-sm-12 {
    width: 100%;
  }
  .col-sm-11 {
    width: 91.66666667%;
  }
  .col-sm-10 {
    width: 83.33333333%;
  }
  .col-sm-9 {
    width: 75%;
  }
  .col-sm-8 {
    width: 66.66666667%;
  }
  .col-sm-7 {
    width: 58.33333333%;
  }
  .col-sm-6 {
    width: 50%;
  }
  .col-sm-5 {
    width: 41.66666667%;
  }
  .col-sm-4 {
    width: 33.33333333%;
  }
  .col-sm-3 {
    width: 25%;
  }
  .col-sm-2 {
    width: 16.66666667%;
  }
  .col-sm-1 {
    width: 8.33333333%;
  }
  .col-sm-pull-12 {
    right: 100%;
  }
  .col-sm-pull-11 {
    right: 91.66666667%;
  }
  .col-sm-pull-10 {
    right: 83.33333333%;
  }
  .col-sm-pull-9 {
    right: 75%;
  }
  .col-sm-pull-8 {
    right: 66.66666667%;
  }
  .col-sm-pull-7 {
    right: 58.33333333%;
  }
  .col-sm-pull-6 {
    right: 50%;
  }
  .col-sm-pull-5 {
    right: 41.66666667%;
  }
  .col-sm-pull-4 {
    right: 33.33333333%;
  }
  .col-sm-pull-3 {
    right: 25%;
  }
  .col-sm-pull-2 {
    right: 16.66666667%;
  }
  .col-sm-pull-1 {
    right: 8.33333333%;
  }
  .col-sm-pull-0 {
    right: auto;
  }
  .col-sm-push-12 {
    left: 100%;
  }
  .col-sm-push-11 {
    left: 91.66666667%;
  }
  .col-sm-push-10 {
    left: 83.33333333%;
  }
  .col-sm-push-9 {
    left: 75%;
  }
  .col-sm-push-8 {
    left: 66.66666667%;
  }
  .col-sm-push-7 {
    left: 58.33333333%;
  }
  .col-sm-push-6 {
    left: 50%;
  }
  .col-sm-push-5 {
    left: 41.66666667%;
  }
  .col-sm-push-4 {
    left: 33.33333333%;
  }
  .col-sm-push-3 {
    left: 25%;
  }
  .col-sm-push-2 {
    left: 16.66666667%;
  }
  .col-sm-push-1 {
    left: 8.33333333%;
  }
  .col-sm-push-0 {
    left: auto;
  }
  .col-sm-offset-12 {
    margin-left: 100%;
  }
  .col-sm-offset-11 {
    margin-left: 91.66666667%;
  }
  .col-sm-offset-10 {
    margin-left: 83.33333333%;
  }
  .col-sm-offset-9 {
    margin-left: 75%;
  }
  .col-sm-offset-8 {
    margin-left: 66.66666667%;
  }
  .col-sm-offset-7 {
    margin-left: 58.33333333%;
  }
  .col-sm-offset-6 {
    margin-left: 50%;
  }
  .col-sm-offset-5 {
    margin-left: 41.66666667%;
  }
  .col-sm-offset-4 {
    margin-left: 33.33333333%;
  }
  .col-sm-offset-3 {
    margin-left: 25%;
  }
  .col-sm-offset-2 {
    margin-left: 16.66666667%;
  }
  .col-sm-offset-1 {
    margin-left: 8.33333333%;
  }
  .col-sm-offset-0 {
    margin-left: 0%;
  }
}
@media (min-width: 992px) {
  .col-md-1, .col-md-2, .col-md-3, .col-md-4, .col-md-5, .col-md-6, .col-md-7, .col-md-8, .col-md-9, .col-md-10, .col-md-11, .col-md-12 {
    float: left;
  }
  .col-md-12 {
    width: 100%;
  }
  .col-md-11 {
    width: 91.66666667%;
  }
  .col-md-10 {
    width: 83.33333333%;
  }
  .col-md-9 {
    width: 75%;
  }
  .col-md-8 {
    width: 66.66666667%;
  }
  .col-md-7 {
    width: 58.33333333%;
  }
  .col-md-6 {
    width: 50%;
  }
  .col-md-5 {
    width: 41.66666667%;
  }
  .col-md-4 {
    width: 33.33333333%;
  }
  .col-md-3 {
    width: 25%;
  }
  .col-md-2 {
    width: 16.66666667%;
  }
  .col-md-1 {
    width: 8.33333333%;
  }
  .col-md-pull-12 {
    right: 100%;
  }
  .col-md-pull-11 {
    right: 91.66666667%;
  }
  .col-md-pull-10 {
    right: 83.33333333%;
  }
  .col-md-pull-9 {
    right: 75%;
  }
  .col-md-pull-8 {
    right: 66.66666667%;
  }
  .col-md-pull-7 {
    right: 58.33333333%;
  }
  .col-md-pull-6 {
    right: 50%;
  }
  .col-md-pull-5 {
    right: 41.66666667%;
  }
  .col-md-pull-4 {
    right: 33.33333333%;
  }
  .col-md-pull-3 {
    right: 25%;
  }
  .col-md-pull-2 {
    right: 16.66666667%;
  }
  .col-md-pull-1 {
    right: 8.33333333%;
  }
  .col-md-pull-0 {
    right: auto;
  }
  .col-md-push-12 {
    left: 100%;
  }
  .col-md-push-11 {
    left: 91.66666667%;
  }
  .col-md-push-10 {
    left: 83.33333333%;
  }
  .col-md-push-9 {
    left: 75%;
  }
  .col-md-push-8 {
    left: 66.66666667%;
  }
  .col-md-push-7 {
    left: 58.33333333%;
  }
  .col-md-push-6 {
    left: 50%;
  }
  .col-md-push-5 {
    left: 41.66666667%;
  }
  .col-md-push-4 {
    left: 33.33333333%;
  }
  .col-md-push-3 {
    left: 25%;
  }
  .col-md-push-2 {
    left: 16.66666667%;
  }
  .col-md-push-1 {
    left: 8.33333333%;
  }
  .col-md-push-0 {
    left: auto;
  }
  .col-md-offset-12 {
    margin-left: 100%;
  }
  .col-md-offset-11 {
    margin-left: 91.66666667%;
  }
  .col-md-offset-10 {
    margin-left: 83.33333333%;
  }
  .col-md-offset-9 {
    margin-left: 75%;
  }
  .col-md-offset-8 {
    margin-left: 66.66666667%;
  }
  .col-md-offset-7 {
    margin-left: 58.33333333%;
  }
  .col-md-offset-6 {
    margin-left: 50%;
  }
  .col-md-offset-5 {
    margin-left: 41.66666667%;
  }
  .col-md-offset-4 {
    margin-left: 33.33333333%;
  }
  .col-md-offset-3 {
    margin-left: 25%;
  }
  .col-md-offset-2 {
    margin-left: 16.66666667%;
  }
  .col-md-offset-1 {
    margin-left: 8.33333333%;
  }
  .col-md-offset-0 {
    margin-left: 0%;
  }
}
@media (min-width: 1200px) {
  .col-lg-1, .col-lg-2, .col-lg-3, .col-lg-4, .col-lg-5, .col-lg-6, .col-lg-7, .col-lg-8, .col-lg-9, .col-lg-10, .col-lg-11, .col-lg-12 {
    float: left;
  }
  .col-lg-12 {
    width: 100%;
  }
  .col-lg-11 {
    width: 91.66666667%;
  }
  .col-lg-10 {
    width: 83.33333333%;
  }
  .col-lg-9 {
    width: 75%;
  }
  .col-lg-8 {
    width: 66.66666667%;
  }
  .col-lg-7 {
    width: 58.33333333%;
  }
  .col-lg-6 {
    width: 50%;
  }
  .col-lg-5 {
    width: 41.66666667%;
  }
  .col-lg-4 {
    width: 33.33333333%;
  }
  .col-lg-3 {
    width: 25%;
  }
  .col-lg-2 {
    width: 16.66666667%;
  }
  .col-lg-1 {
    width: 8.33333333%;
  }
  .col-lg-pull-12 {
    right: 100%;
  }
  .col-lg-pull-11 {
    right: 91.66666667%;
  }
  .col-lg-pull-10 {
    right: 83.33333333%;
  }
  .col-lg-pull-9 {
    right: 75%;
  }
  .col-lg-pull-8 {
    right: 66.66666667%;
  }
  .col-lg-pull-7 {
    right: 58.33333333%;
  }
  .col-lg-pull-6 {
    right: 50%;
  }
  .col-lg-pull-5 {
    right: 41.66666667%;
  }
  .col-lg-pull-4 {
    right: 33.33333333%;
  }
  .col-lg-pull-3 {
    right: 25%;
  }
  .col-lg-pull-2 {
    right: 16.66666667%;
  }
  .col-lg-pull-1 {
    right: 8.33333333%;
  }
  .col-lg-pull-0 {
    right: auto;
  }
  .col-lg-push-12 {
    left: 100%;
  }
  .col-lg-push-11 {
    left: 91.66666667%;
  }
  .col-lg-push-10 {
    left: 83.33333333%;
  }
  .col-lg-push-9 {
    left: 75%;
  }
  .col-lg-push-8 {
    left: 66.66666667%;
  }
  .col-lg-push-7 {
    left: 58.33333333%;
  }
  .col-lg-push-6 {
    left: 50%;
  }
  .col-lg-push-5 {
    left: 41.66666667%;
  }
  .col-lg-push-4 {
    left: 33.33333333%;
  }
  .col-lg-push-3 {
    left: 25%;
  }
  .col-lg-push-2 {
    left: 16.66666667%;
  }
  .col-lg-push-1 {
    left: 8.33333333%;
  }
  .col-lg-push-0 {
    left: auto;
  }
  .col-lg-offset-12 {
    margin-left: 100%;
  }
  .col-lg-offset-11 {
    margin-left: 91.66666667%;
  }
  .col-lg-offset-10 {
    margin-left: 83.33333333%;
  }
  .col-lg-offset-9 {
    margin-left: 75%;
  }
  .col-lg-offset-8 {
    margin-left: 66.66666667%;
  }
  .col-lg-offset-7 {
    margin-left: 58.33333333%;
  }
  .col-lg-offset-6 {
    margin-left: 50%;
  }
  .col-lg-offset-5 {
    margin-left: 41.66666667%;
  }
  .col-lg-offset-4 {
    margin-left: 33.33333333%;
  }
  .col-lg-offset-3 {
    margin-left: 25%;
  }
  .col-lg-offset-2 {
    margin-left: 16.66666667%;
  }
  .col-lg-offset-1 {
    margin-left: 8.33333333%;
  }
  .col-lg-offset-0 {
    margin-left: 0%;
  }
}
table {
  background-color: transparent;
}
caption {
  padding-top: 8px;
  padding-bottom: 8px;
  color: #777777;
  text-align: left;
}
th {
  text-align: left;
}
.table {
  width: 100%;
  max-width: 100%;
  margin-bottom: 18px;
}
.table > thead > tr > th,
.table > tbody > tr > th,
.table > tfoot > tr > th,
.table > thead > tr > td,
.table > tbody > tr > td,
.table > tfoot > tr > td {
  padding: 8px;
  line-height: 1.42857143;
  vertical-align: top;
  border-top: 1px solid #ddd;
}
.table > thead > tr > th {
  vertical-align: bottom;
  border-bottom: 2px solid #ddd;
}
.table > caption + thead > tr:first-child > th,
.table > colgroup + thead > tr:first-child > th,
.table > thead:first-child > tr:first-child > th,
.table > caption + thead > tr:first-child > td,
.table > colgroup + thead > tr:first-child > td,
.table > thead:first-child > tr:first-child > td {
  border-top: 0;
}
.table > tbody + tbody {
  border-top: 2px solid #ddd;
}
.table .table {
  background-color: #fff;
}
.table-condensed > thead > tr > th,
.table-condensed > tbody > tr > th,
.table-condensed > tfoot > tr > th,
.table-condensed > thead > tr > td,
.table-condensed > tbody > tr > td,
.table-condensed > tfoot > tr > td {
  padding: 5px;
}
.table-bordered {
  border: 1px solid #ddd;
}
.table-bordered > thead > tr > th,
.table-bordered > tbody > tr > th,
.table-bordered > tfoot > tr > th,
.table-bordered > thead > tr > td,
.table-bordered > tbody > tr > td,
.table-bordered > tfoot > tr > td {
  border: 1px solid #ddd;
}
.table-bordered > thead > tr > th,
.table-bordered > thead > tr > td {
  border-bottom-width: 2px;
}
.table-striped > tbody > tr:nth-of-type(odd) {
  background-color: #f9f9f9;
}
.table-hover > tbody > tr:hover {
  background-color: #f5f5f5;
}
table col[class*="col-"] {
  position: static;
  float: none;
  display: table-column;
}
table td[class*="col-"],
table th[class*="col-"] {
  position: static;
  float: none;
  display: table-cell;
}
.table > thead > tr > td.active,
.table > tbody > tr > td.active,
.table > tfoot > tr > td.active,
.table > thead > tr > th.active,
.table > tbody > tr > th.active,
.table > tfoot > tr > th.active,
.table > thead > tr.active > td,
.table > tbody > tr.active > td,
.table > tfoot > tr.active > td,
.table > thead > tr.active > th,
.table > tbody > tr.active > th,
.table > tfoot > tr.active > th {
  background-color: #f5f5f5;
}
.table-hover > tbody > tr > td.active:hover,
.table-hover > tbody > tr > th.active:hover,
.table-hover > tbody > tr.active:hover > td,
.table-hover > tbody > tr:hover > .active,
.table-hover > tbody > tr.active:hover > th {
  background-color: #e8e8e8;
}
.table > thead > tr > td.success,
.table > tbody > tr > td.success,
.table > tfoot > tr > td.success,
.table > thead > tr > th.success,
.table > tbody > tr > th.success,
.table > tfoot > tr > th.success,
.table > thead > tr.success > td,
.table > tbody > tr.success > td,
.table > tfoot > tr.success > td,
.table > thead > tr.success > th,
.table > tbody > tr.success > th,
.table > tfoot > tr.success > th {
  background-color: #dff0d8;
}
.table-hover > tbody > tr > td.success:hover,
.table-hover > tbody > tr > th.success:hover,
.table-hover > tbody > tr.success:hover > td,
.table-hover > tbody > tr:hover > .success,
.table-hover > tbody > tr.success:hover > th {
  background-color: #d0e9c6;
}
.table > thead > tr > td.info,
.table > tbody > tr > td.info,
.table > tfoot > tr > td.info,
.table > thead > tr > th.info,
.table > tbody > tr > th.info,
.table > tfoot > tr > th.info,
.table > thead > tr.info > td,
.table > tbody > tr.info > td,
.table > tfoot > tr.info > td,
.table > thead > tr.info > th,
.table > tbody > tr.info > th,
.table > tfoot > tr.info > th {
  background-color: #d9edf7;
}
.table-hover > tbody > tr > td.info:hover,
.table-hover > tbody > tr > th.info:hover,
.table-hover > tbody > tr.info:hover > td,
.table-hover > tbody > tr:hover > .info,
.table-hover > tbody > tr.info:hover > th {
  background-color: #c4e3f3;
}
.table > thead > tr > td.warning,
.table > tbody > tr > td.warning,
.table > tfoot > tr > td.warning,
.table > thead > tr > th.warning,
.table > tbody > tr > th.warning,
.table > tfoot > tr > th.warning,
.table > thead > tr.warning > td,
.table > tbody > tr.warning > td,
.table > tfoot > tr.warning > td,
.table > thead > tr.warning > th,
.table > tbody > tr.warning > th,
.table > tfoot > tr.warning > th {
  background-color: #fcf8e3;
}
.table-hover > tbody > tr > td.warning:hover,
.table-hover > tbody > tr > th.warning:hover,
.table-hover > tbody > tr.warning:hover > td,
.table-hover > tbody > tr:hover > .warning,
.table-hover > tbody > tr.warning:hover > th {
  background-color: #faf2cc;
}
.table > thead > tr > td.danger,
.table > tbody > tr > td.danger,
.table > tfoot > tr > td.danger,
.table > thead > tr > th.danger,
.table > tbody > tr > th.danger,
.table > tfoot > tr > th.danger,
.table > thead > tr.danger > td,
.table > tbody > tr.danger > td,
.table > tfoot > tr.danger > td,
.table > thead > tr.danger > th,
.table > tbody > tr.danger > th,
.table > tfoot > tr.danger > th {
  background-color: #f2dede;
}
.table-hover > tbody > tr > td.danger:hover,
.table-hover > tbody > tr > th.danger:hover,
.table-hover > tbody > tr.danger:hover > td,
.table-hover > tbody > tr:hover > .danger,
.table-hover > tbody > tr.danger:hover > th {
  background-color: #ebcccc;
}
.table-responsive {
  overflow-x: auto;
  min-height: 0.01%;
}
@media screen and (max-width: 767px) {
  .table-responsive {
    width: 100%;
    margin-bottom: 13.5px;
    overflow-y: hidden;
    -ms-overflow-style: -ms-autohiding-scrollbar;
    border: 1px solid #ddd;
  }
  .table-responsive > .table {
    margin-bottom: 0;
  }
  .table-responsive > .table > thead > tr > th,
  .table-responsive > .table > tbody > tr > th,
  .table-responsive > .table > tfoot > tr > th,
  .table-responsive > .table > thead > tr > td,
  .table-responsive > .table > tbody > tr > td,
  .table-responsive > .table > tfoot > tr > td {
    white-space: nowrap;
  }
  .table-responsive > .table-bordered {
    border: 0;
  }
  .table-responsive > .table-bordered > thead > tr > th:first-child,
  .table-responsive > .table-bordered > tbody > tr > th:first-child,
  .table-responsive > .table-bordered > tfoot > tr > th:first-child,
  .table-responsive > .table-bordered > thead > tr > td:first-child,
  .table-responsive > .table-bordered > tbody > tr > td:first-child,
  .table-responsive > .table-bordered > tfoot > tr > td:first-child {
    border-left: 0;
  }
  .table-responsive > .table-bordered > thead > tr > th:last-child,
  .table-responsive > .table-bordered > tbody > tr > th:last-child,
  .table-responsive > .table-bordered > tfoot > tr > th:last-child,
  .table-responsive > .table-bordered > thead > tr > td:last-child,
  .table-responsive > .table-bordered > tbody > tr > td:last-child,
  .table-responsive > .table-bordered > tfoot > tr > td:last-child {
    border-right: 0;
  }
  .table-responsive > .table-bordered > tbody > tr:last-child > th,
  .table-responsive > .table-bordered > tfoot > tr:last-child > th,
  .table-responsive > .table-bordered > tbody > tr:last-child > td,
  .table-responsive > .table-bordered > tfoot > tr:last-child > td {
    border-bottom: 0;
  }
}
fieldset {
  padding: 0;
  margin: 0;
  border: 0;
  min-width: 0;
}
legend {
  display: block;
  width: 100%;
  padding: 0;
  margin-bottom: 18px;
  font-size: 19.5px;
  line-height: inherit;
  color: #333333;
  border: 0;
  border-bottom: 1px solid #e5e5e5;
}
label {
  display: inline-block;
  max-width: 100%;
  margin-bottom: 5px;
  font-weight: bold;
}
input[type="search"] {
  -webkit-box-sizing: border-box;
  -moz-box-sizing: border-box;
  box-sizing: border-box;
}
input[type="radio"],
input[type="checkbox"] {
  margin: 4px 0 0;
  margin-top: 1px \9;
  line-height: normal;
}
input[type="file"] {
  display: block;
}
input[type="range"] {
  display: block;
  width: 100%;
}
select[multiple],
select[size] {
  height: auto;
}
input[type="file"]:focus,
input[type="radio"]:focus,
input[type="checkbox"]:focus {
  outline: 5px auto -webkit-focus-ring-color;
  outline-offset: -2px;
}
output {
  display: block;
  padding-top: 7px;
  font-size: 13px;
  line-height: 1.42857143;
  color: #555555;
}
.form-control {
  display: block;
  width: 100%;
  height: 32px;
  padding: 6px 12px;
  font-size: 13px;
  line-height: 1.42857143;
  color: #555555;
  background-color: #fff;
  background-image: none;
  border: 1px solid #ccc;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  -webkit-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  -o-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
}
.form-control:focus {
  border-color: #66afe9;
  outline: 0;
  -webkit-box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
  box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
}
.form-control::-moz-placeholder {
  color: #999;
  opacity: 1;
}
.form-control:-ms-input-placeholder {
  color: #999;
}
.form-control::-webkit-input-placeholder {
  color: #999;
}
.form-control::-ms-expand {
  border: 0;
  background-color: transparent;
}
.form-control[disabled],
.form-control[readonly],
fieldset[disabled] .form-control {
  background-color: #eeeeee;
  opacity: 1;
}
.form-control[disabled],
fieldset[disabled] .form-control {
  cursor: not-allowed;
}
textarea.form-control {
  height: auto;
}
input[type="search"] {
  -webkit-appearance: none;
}
@media screen and (-webkit-min-device-pixel-ratio: 0) {
  input[type="date"].form-control,
  input[type="time"].form-control,
  input[type="datetime-local"].form-control,
  input[type="month"].form-control {
    line-height: 32px;
  }
  input[type="date"].input-sm,
  input[type="time"].input-sm,
  input[type="datetime-local"].input-sm,
  input[type="month"].input-sm,
  .input-group-sm input[type="date"],
  .input-group-sm input[type="time"],
  .input-group-sm input[type="datetime-local"],
  .input-group-sm input[type="month"] {
    line-height: 30px;
  }
  input[type="date"].input-lg,
  input[type="time"].input-lg,
  input[type="datetime-local"].input-lg,
  input[type="month"].input-lg,
  .input-group-lg input[type="date"],
  .input-group-lg input[type="time"],
  .input-group-lg input[type="datetime-local"],
  .input-group-lg input[type="month"] {
    line-height: 45px;
  }
}
.form-group {
  margin-bottom: 15px;
}
.radio,
.checkbox {
  position: relative;
  display: block;
  margin-top: 10px;
  margin-bottom: 10px;
}
.radio label,
.checkbox label {
  min-height: 18px;
  padding-left: 20px;
  margin-bottom: 0;
  font-weight: normal;
  cursor: pointer;
}
.radio input[type="radio"],
.radio-inline input[type="radio"],
.checkbox input[type="checkbox"],
.checkbox-inline input[type="checkbox"] {
  position: absolute;
  margin-left: -20px;
  margin-top: 4px \9;
}
.radio + .radio,
.checkbox + .checkbox {
  margin-top: -5px;
}
.radio-inline,
.checkbox-inline {
  position: relative;
  display: inline-block;
  padding-left: 20px;
  margin-bottom: 0;
  vertical-align: middle;
  font-weight: normal;
  cursor: pointer;
}
.radio-inline + .radio-inline,
.checkbox-inline + .checkbox-inline {
  margin-top: 0;
  margin-left: 10px;
}
input[type="radio"][disabled],
input[type="checkbox"][disabled],
input[type="radio"].disabled,
input[type="checkbox"].disabled,
fieldset[disabled] input[type="radio"],
fieldset[disabled] input[type="checkbox"] {
  cursor: not-allowed;
}
.radio-inline.disabled,
.checkbox-inline.disabled,
fieldset[disabled] .radio-inline,
fieldset[disabled] .checkbox-inline {
  cursor: not-allowed;
}
.radio.disabled label,
.checkbox.disabled label,
fieldset[disabled] .radio label,
fieldset[disabled] .checkbox label {
  cursor: not-allowed;
}
.form-control-static {
  padding-top: 7px;
  padding-bottom: 7px;
  margin-bottom: 0;
  min-height: 31px;
}
.form-control-static.input-lg,
.form-control-static.input-sm {
  padding-left: 0;
  padding-right: 0;
}
.input-sm {
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
select.input-sm {
  height: 30px;
  line-height: 30px;
}
textarea.input-sm,
select[multiple].input-sm {
  height: auto;
}
.form-group-sm .form-control {
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
.form-group-sm select.form-control {
  height: 30px;
  line-height: 30px;
}
.form-group-sm textarea.form-control,
.form-group-sm select[multiple].form-control {
  height: auto;
}
.form-group-sm .form-control-static {
  height: 30px;
  min-height: 30px;
  padding: 6px 10px;
  font-size: 12px;
  line-height: 1.5;
}
.input-lg {
  height: 45px;
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
select.input-lg {
  height: 45px;
  line-height: 45px;
}
textarea.input-lg,
select[multiple].input-lg {
  height: auto;
}
.form-group-lg .form-control {
  height: 45px;
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
.form-group-lg select.form-control {
  height: 45px;
  line-height: 45px;
}
.form-group-lg textarea.form-control,
.form-group-lg select[multiple].form-control {
  height: auto;
}
.form-group-lg .form-control-static {
  height: 45px;
  min-height: 35px;
  padding: 11px 16px;
  font-size: 17px;
  line-height: 1.3333333;
}
.has-feedback {
  position: relative;
}
.has-feedback .form-control {
  padding-right: 40px;
}
.form-control-feedback {
  position: absolute;
  top: 0;
  right: 0;
  z-index: 2;
  display: block;
  width: 32px;
  height: 32px;
  line-height: 32px;
  text-align: center;
  pointer-events: none;
}
.input-lg + .form-control-feedback,
.input-group-lg + .form-control-feedback,
.form-group-lg .form-control + .form-control-feedback {
  width: 45px;
  height: 45px;
  line-height: 45px;
}
.input-sm + .form-control-feedback,
.input-group-sm + .form-control-feedback,
.form-group-sm .form-control + .form-control-feedback {
  width: 30px;
  height: 30px;
  line-height: 30px;
}
.has-success .help-block,
.has-success .control-label,
.has-success .radio,
.has-success .checkbox,
.has-success .radio-inline,
.has-success .checkbox-inline,
.has-success.radio label,
.has-success.checkbox label,
.has-success.radio-inline label,
.has-success.checkbox-inline label {
  color: #3c763d;
}
.has-success .form-control {
  border-color: #3c763d;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
}
.has-success .form-control:focus {
  border-color: #2b542c;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #67b168;
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #67b168;
}
.has-success .input-group-addon {
  color: #3c763d;
  border-color: #3c763d;
  background-color: #dff0d8;
}
.has-success .form-control-feedback {
  color: #3c763d;
}
.has-warning .help-block,
.has-warning .control-label,
.has-warning .radio,
.has-warning .checkbox,
.has-warning .radio-inline,
.has-warning .checkbox-inline,
.has-warning.radio label,
.has-warning.checkbox label,
.has-warning.radio-inline label,
.has-warning.checkbox-inline label {
  color: #8a6d3b;
}
.has-warning .form-control {
  border-color: #8a6d3b;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
}
.has-warning .form-control:focus {
  border-color: #66512c;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #c0a16b;
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #c0a16b;
}
.has-warning .input-group-addon {
  color: #8a6d3b;
  border-color: #8a6d3b;
  background-color: #fcf8e3;
}
.has-warning .form-control-feedback {
  color: #8a6d3b;
}
.has-error .help-block,
.has-error .control-label,
.has-error .radio,
.has-error .checkbox,
.has-error .radio-inline,
.has-error .checkbox-inline,
.has-error.radio label,
.has-error.checkbox label,
.has-error.radio-inline label,
.has-error.checkbox-inline label {
  color: #a94442;
}
.has-error .form-control {
  border-color: #a94442;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
}
.has-error .form-control:focus {
  border-color: #843534;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #ce8483;
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #ce8483;
}
.has-error .input-group-addon {
  color: #a94442;
  border-color: #a94442;
  background-color: #f2dede;
}
.has-error .form-control-feedback {
  color: #a94442;
}
.has-feedback label ~ .form-control-feedback {
  top: 23px;
}
.has-feedback label.sr-only ~ .form-control-feedback {
  top: 0;
}
.help-block {
  display: block;
  margin-top: 5px;
  margin-bottom: 10px;
  color: #404040;
}
@media (min-width: 768px) {
  .form-inline .form-group {
    display: inline-block;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .form-inline .form-control {
    display: inline-block;
    width: auto;
    vertical-align: middle;
  }
  .form-inline .form-control-static {
    display: inline-block;
  }
  .form-inline .input-group {
    display: inline-table;
    vertical-align: middle;
  }
  .form-inline .input-group .input-group-addon,
  .form-inline .input-group .input-group-btn,
  .form-inline .input-group .form-control {
    width: auto;
  }
  .form-inline .input-group > .form-control {
    width: 100%;
  }
  .form-inline .control-label {
    margin-bottom: 0;
    vertical-align: middle;
  }
  .form-inline .radio,
  .form-inline .checkbox {
    display: inline-block;
    margin-top: 0;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .form-inline .radio label,
  .form-inline .checkbox label {
    padding-left: 0;
  }
  .form-inline .radio input[type="radio"],
  .form-inline .checkbox input[type="checkbox"] {
    position: relative;
    margin-left: 0;
  }
  .form-inline .has-feedback .form-control-feedback {
    top: 0;
  }
}
.form-horizontal .radio,
.form-horizontal .checkbox,
.form-horizontal .radio-inline,
.form-horizontal .checkbox-inline {
  margin-top: 0;
  margin-bottom: 0;
  padding-top: 7px;
}
.form-horizontal .radio,
.form-horizontal .checkbox {
  min-height: 25px;
}
.form-horizontal .form-group {
  margin-left: 0px;
  margin-right: 0px;
}
@media (min-width: 768px) {
  .form-horizontal .control-label {
    text-align: right;
    margin-bottom: 0;
    padding-top: 7px;
  }
}
.form-horizontal .has-feedback .form-control-feedback {
  right: 0px;
}
@media (min-width: 768px) {
  .form-horizontal .form-group-lg .control-label {
    padding-top: 11px;
    font-size: 17px;
  }
}
@media (min-width: 768px) {
  .form-horizontal .form-group-sm .control-label {
    padding-top: 6px;
    font-size: 12px;
  }
}
.btn {
  display: inline-block;
  margin-bottom: 0;
  font-weight: normal;
  text-align: center;
  vertical-align: middle;
  touch-action: manipulation;
  cursor: pointer;
  background-image: none;
  border: 1px solid transparent;
  white-space: nowrap;
  padding: 6px 12px;
  font-size: 13px;
  line-height: 1.42857143;
  border-radius: 2px;
  -webkit-user-select: none;
  -moz-user-select: none;
  -ms-user-select: none;
  user-select: none;
}
.btn:focus,
.btn:active:focus,
.btn.active:focus,
.btn.focus,
.btn:active.focus,
.btn.active.focus {
  outline: 5px auto -webkit-focus-ring-color;
  outline-offset: -2px;
}
.btn:hover,
.btn:focus,
.btn.focus {
  color: #333;
  text-decoration: none;
}
.btn:active,
.btn.active {
  outline: 0;
  background-image: none;
  -webkit-box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
  box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
}
.btn.disabled,
.btn[disabled],
fieldset[disabled] .btn {
  cursor: not-allowed;
  opacity: 0.65;
  filter: alpha(opacity=65);
  -webkit-box-shadow: none;
  box-shadow: none;
}
a.btn.disabled,
fieldset[disabled] a.btn {
  pointer-events: none;
}
.btn-default {
  color: #333;
  background-color: #fff;
  border-color: #ccc;
}
.btn-default:focus,
.btn-default.focus {
  color: #333;
  background-color: #e6e6e6;
  border-color: #8c8c8c;
}
.btn-default:hover {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.btn-default:active,
.btn-default.active,
.open > .dropdown-toggle.btn-default {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.btn-default:active:hover,
.btn-default.active:hover,
.open > .dropdown-toggle.btn-default:hover,
.btn-default:active:focus,
.btn-default.active:focus,
.open > .dropdown-toggle.btn-default:focus,
.btn-default:active.focus,
.btn-default.active.focus,
.open > .dropdown-toggle.btn-default.focus {
  color: #333;
  background-color: #d4d4d4;
  border-color: #8c8c8c;
}
.btn-default:active,
.btn-default.active,
.open > .dropdown-toggle.btn-default {
  background-image: none;
}
.btn-default.disabled:hover,
.btn-default[disabled]:hover,
fieldset[disabled] .btn-default:hover,
.btn-default.disabled:focus,
.btn-default[disabled]:focus,
fieldset[disabled] .btn-default:focus,
.btn-default.disabled.focus,
.btn-default[disabled].focus,
fieldset[disabled] .btn-default.focus {
  background-color: #fff;
  border-color: #ccc;
}
.btn-default .badge {
  color: #fff;
  background-color: #333;
}
.btn-primary {
  color: #fff;
  background-color: #337ab7;
  border-color: #2e6da4;
}
.btn-primary:focus,
.btn-primary.focus {
  color: #fff;
  background-color: #286090;
  border-color: #122b40;
}
.btn-primary:hover {
  color: #fff;
  background-color: #286090;
  border-color: #204d74;
}
.btn-primary:active,
.btn-primary.active,
.open > .dropdown-toggle.btn-primary {
  color: #fff;
  background-color: #286090;
  border-color: #204d74;
}
.btn-primary:active:hover,
.btn-primary.active:hover,
.open > .dropdown-toggle.btn-primary:hover,
.btn-primary:active:focus,
.btn-primary.active:focus,
.open > .dropdown-toggle.btn-primary:focus,
.btn-primary:active.focus,
.btn-primary.active.focus,
.open > .dropdown-toggle.btn-primary.focus {
  color: #fff;
  background-color: #204d74;
  border-color: #122b40;
}
.btn-primary:active,
.btn-primary.active,
.open > .dropdown-toggle.btn-primary {
  background-image: none;
}
.btn-primary.disabled:hover,
.btn-primary[disabled]:hover,
fieldset[disabled] .btn-primary:hover,
.btn-primary.disabled:focus,
.btn-primary[disabled]:focus,
fieldset[disabled] .btn-primary:focus,
.btn-primary.disabled.focus,
.btn-primary[disabled].focus,
fieldset[disabled] .btn-primary.focus {
  background-color: #337ab7;
  border-color: #2e6da4;
}
.btn-primary .badge {
  color: #337ab7;
  background-color: #fff;
}
.btn-success {
  color: #fff;
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.btn-success:focus,
.btn-success.focus {
  color: #fff;
  background-color: #449d44;
  border-color: #255625;
}
.btn-success:hover {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.btn-success:active,
.btn-success.active,
.open > .dropdown-toggle.btn-success {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.btn-success:active:hover,
.btn-success.active:hover,
.open > .dropdown-toggle.btn-success:hover,
.btn-success:active:focus,
.btn-success.active:focus,
.open > .dropdown-toggle.btn-success:focus,
.btn-success:active.focus,
.btn-success.active.focus,
.open > .dropdown-toggle.btn-success.focus {
  color: #fff;
  background-color: #398439;
  border-color: #255625;
}
.btn-success:active,
.btn-success.active,
.open > .dropdown-toggle.btn-success {
  background-image: none;
}
.btn-success.disabled:hover,
.btn-success[disabled]:hover,
fieldset[disabled] .btn-success:hover,
.btn-success.disabled:focus,
.btn-success[disabled]:focus,
fieldset[disabled] .btn-success:focus,
.btn-success.disabled.focus,
.btn-success[disabled].focus,
fieldset[disabled] .btn-success.focus {
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.btn-success .badge {
  color: #5cb85c;
  background-color: #fff;
}
.btn-info {
  color: #fff;
  background-color: #5bc0de;
  border-color: #46b8da;
}
.btn-info:focus,
.btn-info.focus {
  color: #fff;
  background-color: #31b0d5;
  border-color: #1b6d85;
}
.btn-info:hover {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.btn-info:active,
.btn-info.active,
.open > .dropdown-toggle.btn-info {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.btn-info:active:hover,
.btn-info.active:hover,
.open > .dropdown-toggle.btn-info:hover,
.btn-info:active:focus,
.btn-info.active:focus,
.open > .dropdown-toggle.btn-info:focus,
.btn-info:active.focus,
.btn-info.active.focus,
.open > .dropdown-toggle.btn-info.focus {
  color: #fff;
  background-color: #269abc;
  border-color: #1b6d85;
}
.btn-info:active,
.btn-info.active,
.open > .dropdown-toggle.btn-info {
  background-image: none;
}
.btn-info.disabled:hover,
.btn-info[disabled]:hover,
fieldset[disabled] .btn-info:hover,
.btn-info.disabled:focus,
.btn-info[disabled]:focus,
fieldset[disabled] .btn-info:focus,
.btn-info.disabled.focus,
.btn-info[disabled].focus,
fieldset[disabled] .btn-info.focus {
  background-color: #5bc0de;
  border-color: #46b8da;
}
.btn-info .badge {
  color: #5bc0de;
  background-color: #fff;
}
.btn-warning {
  color: #fff;
  background-color: #f0ad4e;
  border-color: #eea236;
}
.btn-warning:focus,
.btn-warning.focus {
  color: #fff;
  background-color: #ec971f;
  border-color: #985f0d;
}
.btn-warning:hover {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.btn-warning:active,
.btn-warning.active,
.open > .dropdown-toggle.btn-warning {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.btn-warning:active:hover,
.btn-warning.active:hover,
.open > .dropdown-toggle.btn-warning:hover,
.btn-warning:active:focus,
.btn-warning.active:focus,
.open > .dropdown-toggle.btn-warning:focus,
.btn-warning:active.focus,
.btn-warning.active.focus,
.open > .dropdown-toggle.btn-warning.focus {
  color: #fff;
  background-color: #d58512;
  border-color: #985f0d;
}
.btn-warning:active,
.btn-warning.active,
.open > .dropdown-toggle.btn-warning {
  background-image: none;
}
.btn-warning.disabled:hover,
.btn-warning[disabled]:hover,
fieldset[disabled] .btn-warning:hover,
.btn-warning.disabled:focus,
.btn-warning[disabled]:focus,
fieldset[disabled] .btn-warning:focus,
.btn-warning.disabled.focus,
.btn-warning[disabled].focus,
fieldset[disabled] .btn-warning.focus {
  background-color: #f0ad4e;
  border-color: #eea236;
}
.btn-warning .badge {
  color: #f0ad4e;
  background-color: #fff;
}
.btn-danger {
  color: #fff;
  background-color: #d9534f;
  border-color: #d43f3a;
}
.btn-danger:focus,
.btn-danger.focus {
  color: #fff;
  background-color: #c9302c;
  border-color: #761c19;
}
.btn-danger:hover {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.btn-danger:active,
.btn-danger.active,
.open > .dropdown-toggle.btn-danger {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.btn-danger:active:hover,
.btn-danger.active:hover,
.open > .dropdown-toggle.btn-danger:hover,
.btn-danger:active:focus,
.btn-danger.active:focus,
.open > .dropdown-toggle.btn-danger:focus,
.btn-danger:active.focus,
.btn-danger.active.focus,
.open > .dropdown-toggle.btn-danger.focus {
  color: #fff;
  background-color: #ac2925;
  border-color: #761c19;
}
.btn-danger:active,
.btn-danger.active,
.open > .dropdown-toggle.btn-danger {
  background-image: none;
}
.btn-danger.disabled:hover,
.btn-danger[disabled]:hover,
fieldset[disabled] .btn-danger:hover,
.btn-danger.disabled:focus,
.btn-danger[disabled]:focus,
fieldset[disabled] .btn-danger:focus,
.btn-danger.disabled.focus,
.btn-danger[disabled].focus,
fieldset[disabled] .btn-danger.focus {
  background-color: #d9534f;
  border-color: #d43f3a;
}
.btn-danger .badge {
  color: #d9534f;
  background-color: #fff;
}
.btn-link {
  color: #337ab7;
  font-weight: normal;
  border-radius: 0;
}
.btn-link,
.btn-link:active,
.btn-link.active,
.btn-link[disabled],
fieldset[disabled] .btn-link {
  background-color: transparent;
  -webkit-box-shadow: none;
  box-shadow: none;
}
.btn-link,
.btn-link:hover,
.btn-link:focus,
.btn-link:active {
  border-color: transparent;
}
.btn-link:hover,
.btn-link:focus {
  color: #23527c;
  text-decoration: underline;
  background-color: transparent;
}
.btn-link[disabled]:hover,
fieldset[disabled] .btn-link:hover,
.btn-link[disabled]:focus,
fieldset[disabled] .btn-link:focus {
  color: #777777;
  text-decoration: none;
}
.btn-lg,
.btn-group-lg > .btn {
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
.btn-sm,
.btn-group-sm > .btn {
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
.btn-xs,
.btn-group-xs > .btn {
  padding: 1px 5px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
.btn-block {
  display: block;
  width: 100%;
}
.btn-block + .btn-block {
  margin-top: 5px;
}
input[type="submit"].btn-block,
input[type="reset"].btn-block,
input[type="button"].btn-block {
  width: 100%;
}
.fade {
  opacity: 0;
  -webkit-transition: opacity 0.15s linear;
  -o-transition: opacity 0.15s linear;
  transition: opacity 0.15s linear;
}
.fade.in {
  opacity: 1;
}
.collapse {
  display: none;
}
.collapse.in {
  display: block;
}
tr.collapse.in {
  display: table-row;
}
tbody.collapse.in {
  display: table-row-group;
}
.collapsing {
  position: relative;
  height: 0;
  overflow: hidden;
  -webkit-transition-property: height, visibility;
  transition-property: height, visibility;
  -webkit-transition-duration: 0.35s;
  transition-duration: 0.35s;
  -webkit-transition-timing-function: ease;
  transition-timing-function: ease;
}
.caret {
  display: inline-block;
  width: 0;
  height: 0;
  margin-left: 2px;
  vertical-align: middle;
  border-top: 4px dashed;
  border-top: 4px solid \9;
  border-right: 4px solid transparent;
  border-left: 4px solid transparent;
}
.dropup,
.dropdown {
  position: relative;
}
.dropdown-toggle:focus {
  outline: 0;
}
.dropdown-menu {
  position: absolute;
  top: 100%;
  left: 0;
  z-index: 1000;
  display: none;
  float: left;
  min-width: 160px;
  padding: 5px 0;
  margin: 2px 0 0;
  list-style: none;
  font-size: 13px;
  text-align: left;
  background-color: #fff;
  border: 1px solid #ccc;
  border: 1px solid rgba(0, 0, 0, 0.15);
  border-radius: 2px;
  -webkit-box-shadow: 0 6px 12px rgba(0, 0, 0, 0.175);
  box-shadow: 0 6px 12px rgba(0, 0, 0, 0.175);
  background-clip: padding-box;
}
.dropdown-menu.pull-right {
  right: 0;
  left: auto;
}
.dropdown-menu .divider {
  height: 1px;
  margin: 8px 0;
  overflow: hidden;
  background-color: #e5e5e5;
}
.dropdown-menu > li > a {
  display: block;
  padding: 3px 20px;
  clear: both;
  font-weight: normal;
  line-height: 1.42857143;
  color: #333333;
  white-space: nowrap;
}
.dropdown-menu > li > a:hover,
.dropdown-menu > li > a:focus {
  text-decoration: none;
  color: #262626;
  background-color: #f5f5f5;
}
.dropdown-menu > .active > a,
.dropdown-menu > .active > a:hover,
.dropdown-menu > .active > a:focus {
  color: #fff;
  text-decoration: none;
  outline: 0;
  background-color: #337ab7;
}
.dropdown-menu > .disabled > a,
.dropdown-menu > .disabled > a:hover,
.dropdown-menu > .disabled > a:focus {
  color: #777777;
}
.dropdown-menu > .disabled > a:hover,
.dropdown-menu > .disabled > a:focus {
  text-decoration: none;
  background-color: transparent;
  background-image: none;
  filter: progid:DXImageTransform.Microsoft.gradient(enabled = false);
  cursor: not-allowed;
}
.open > .dropdown-menu {
  display: block;
}
.open > a {
  outline: 0;
}
.dropdown-menu-right {
  left: auto;
  right: 0;
}
.dropdown-menu-left {
  left: 0;
  right: auto;
}
.dropdown-header {
  display: block;
  padding: 3px 20px;
  font-size: 12px;
  line-height: 1.42857143;
  color: #777777;
  white-space: nowrap;
}
.dropdown-backdrop {
  position: fixed;
  left: 0;
  right: 0;
  bottom: 0;
  top: 0;
  z-index: 990;
}
.pull-right > .dropdown-menu {
  right: 0;
  left: auto;
}
.dropup .caret,
.navbar-fixed-bottom .dropdown .caret {
  border-top: 0;
  border-bottom: 4px dashed;
  border-bottom: 4px solid \9;
  content: "";
}
.dropup .dropdown-menu,
.navbar-fixed-bottom .dropdown .dropdown-menu {
  top: auto;
  bottom: 100%;
  margin-bottom: 2px;
}
@media (min-width: 541px) {
  .navbar-right .dropdown-menu {
    left: auto;
    right: 0;
  }
  .navbar-right .dropdown-menu-left {
    left: 0;
    right: auto;
  }
}
.btn-group,
.btn-group-vertical {
  position: relative;
  display: inline-block;
  vertical-align: middle;
}
.btn-group > .btn,
.btn-group-vertical > .btn {
  position: relative;
  float: left;
}
.btn-group > .btn:hover,
.btn-group-vertical > .btn:hover,
.btn-group > .btn:focus,
.btn-group-vertical > .btn:focus,
.btn-group > .btn:active,
.btn-group-vertical > .btn:active,
.btn-group > .btn.active,
.btn-group-vertical > .btn.active {
  z-index: 2;
}
.btn-group .btn + .btn,
.btn-group .btn + .btn-group,
.btn-group .btn-group + .btn,
.btn-group .btn-group + .btn-group {
  margin-left: -1px;
}
.btn-toolbar {
  margin-left: -5px;
}
.btn-toolbar .btn,
.btn-toolbar .btn-group,
.btn-toolbar .input-group {
  float: left;
}
.btn-toolbar > .btn,
.btn-toolbar > .btn-group,
.btn-toolbar > .input-group {
  margin-left: 5px;
}
.btn-group > .btn:not(:first-child):not(:last-child):not(.dropdown-toggle) {
  border-radius: 0;
}
.btn-group > .btn:first-child {
  margin-left: 0;
}
.btn-group > .btn:first-child:not(:last-child):not(.dropdown-toggle) {
  border-bottom-right-radius: 0;
  border-top-right-radius: 0;
}
.btn-group > .btn:last-child:not(:first-child),
.btn-group > .dropdown-toggle:not(:first-child) {
  border-bottom-left-radius: 0;
  border-top-left-radius: 0;
}
.btn-group > .btn-group {
  float: left;
}
.btn-group > .btn-group:not(:first-child):not(:last-child) > .btn {
  border-radius: 0;
}
.btn-group > .btn-group:first-child:not(:last-child) > .btn:last-child,
.btn-group > .btn-group:first-child:not(:last-child) > .dropdown-toggle {
  border-bottom-right-radius: 0;
  border-top-right-radius: 0;
}
.btn-group > .btn-group:last-child:not(:first-child) > .btn:first-child {
  border-bottom-left-radius: 0;
  border-top-left-radius: 0;
}
.btn-group .dropdown-toggle:active,
.btn-group.open .dropdown-toggle {
  outline: 0;
}
.btn-group > .btn + .dropdown-toggle {
  padding-left: 8px;
  padding-right: 8px;
}
.btn-group > .btn-lg + .dropdown-toggle {
  padding-left: 12px;
  padding-right: 12px;
}
.btn-group.open .dropdown-toggle {
  -webkit-box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
  box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
}
.btn-group.open .dropdown-toggle.btn-link {
  -webkit-box-shadow: none;
  box-shadow: none;
}
.btn .caret {
  margin-left: 0;
}
.btn-lg .caret {
  border-width: 5px 5px 0;
  border-bottom-width: 0;
}
.dropup .btn-lg .caret {
  border-width: 0 5px 5px;
}
.btn-group-vertical > .btn,
.btn-group-vertical > .btn-group,
.btn-group-vertical > .btn-group > .btn {
  display: block;
  float: none;
  width: 100%;
  max-width: 100%;
}
.btn-group-vertical > .btn-group > .btn {
  float: none;
}
.btn-group-vertical > .btn + .btn,
.btn-group-vertical > .btn + .btn-group,
.btn-group-vertical > .btn-group + .btn,
.btn-group-vertical > .btn-group + .btn-group {
  margin-top: -1px;
  margin-left: 0;
}
.btn-group-vertical > .btn:not(:first-child):not(:last-child) {
  border-radius: 0;
}
.btn-group-vertical > .btn:first-child:not(:last-child) {
  border-top-right-radius: 2px;
  border-top-left-radius: 2px;
  border-bottom-right-radius: 0;
  border-bottom-left-radius: 0;
}
.btn-group-vertical > .btn:last-child:not(:first-child) {
  border-top-right-radius: 0;
  border-top-left-radius: 0;
  border-bottom-right-radius: 2px;
  border-bottom-left-radius: 2px;
}
.btn-group-vertical > .btn-group:not(:first-child):not(:last-child) > .btn {
  border-radius: 0;
}
.btn-group-vertical > .btn-group:first-child:not(:last-child) > .btn:last-child,
.btn-group-vertical > .btn-group:first-child:not(:last-child) > .dropdown-toggle {
  border-bottom-right-radius: 0;
  border-bottom-left-radius: 0;
}
.btn-group-vertical > .btn-group:last-child:not(:first-child) > .btn:first-child {
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.btn-group-justified {
  display: table;
  width: 100%;
  table-layout: fixed;
  border-collapse: separate;
}
.btn-group-justified > .btn,
.btn-group-justified > .btn-group {
  float: none;
  display: table-cell;
  width: 1%;
}
.btn-group-justified > .btn-group .btn {
  width: 100%;
}
.btn-group-justified > .btn-group .dropdown-menu {
  left: auto;
}
[data-toggle="buttons"] > .btn input[type="radio"],
[data-toggle="buttons"] > .btn-group > .btn input[type="radio"],
[data-toggle="buttons"] > .btn input[type="checkbox"],
[data-toggle="buttons"] > .btn-group > .btn input[type="checkbox"] {
  position: absolute;
  clip: rect(0, 0, 0, 0);
  pointer-events: none;
}
.input-group {
  position: relative;
  display: table;
  border-collapse: separate;
}
.input-group[class*="col-"] {
  float: none;
  padding-left: 0;
  padding-right: 0;
}
.input-group .form-control {
  position: relative;
  z-index: 2;
  float: left;
  width: 100%;
  margin-bottom: 0;
}
.input-group .form-control:focus {
  z-index: 3;
}
.input-group-lg > .form-control,
.input-group-lg > .input-group-addon,
.input-group-lg > .input-group-btn > .btn {
  height: 45px;
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
select.input-group-lg > .form-control,
select.input-group-lg > .input-group-addon,
select.input-group-lg > .input-group-btn > .btn {
  height: 45px;
  line-height: 45px;
}
textarea.input-group-lg > .form-control,
textarea.input-group-lg > .input-group-addon,
textarea.input-group-lg > .input-group-btn > .btn,
select[multiple].input-group-lg > .form-control,
select[multiple].input-group-lg > .input-group-addon,
select[multiple].input-group-lg > .input-group-btn > .btn {
  height: auto;
}
.input-group-sm > .form-control,
.input-group-sm > .input-group-addon,
.input-group-sm > .input-group-btn > .btn {
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
select.input-group-sm > .form-control,
select.input-group-sm > .input-group-addon,
select.input-group-sm > .input-group-btn > .btn {
  height: 30px;
  line-height: 30px;
}
textarea.input-group-sm > .form-control,
textarea.input-group-sm > .input-group-addon,
textarea.input-group-sm > .input-group-btn > .btn,
select[multiple].input-group-sm > .form-control,
select[multiple].input-group-sm > .input-group-addon,
select[multiple].input-group-sm > .input-group-btn > .btn {
  height: auto;
}
.input-group-addon,
.input-group-btn,
.input-group .form-control {
  display: table-cell;
}
.input-group-addon:not(:first-child):not(:last-child),
.input-group-btn:not(:first-child):not(:last-child),
.input-group .form-control:not(:first-child):not(:last-child) {
  border-radius: 0;
}
.input-group-addon,
.input-group-btn {
  width: 1%;
  white-space: nowrap;
  vertical-align: middle;
}
.input-group-addon {
  padding: 6px 12px;
  font-size: 13px;
  font-weight: normal;
  line-height: 1;
  color: #555555;
  text-align: center;
  background-color: #eeeeee;
  border: 1px solid #ccc;
  border-radius: 2px;
}
.input-group-addon.input-sm {
  padding: 5px 10px;
  font-size: 12px;
  border-radius: 1px;
}
.input-group-addon.input-lg {
  padding: 10px 16px;
  font-size: 17px;
  border-radius: 3px;
}
.input-group-addon input[type="radio"],
.input-group-addon input[type="checkbox"] {
  margin-top: 0;
}
.input-group .form-control:first-child,
.input-group-addon:first-child,
.input-group-btn:first-child > .btn,
.input-group-btn:first-child > .btn-group > .btn,
.input-group-btn:first-child > .dropdown-toggle,
.input-group-btn:last-child > .btn:not(:last-child):not(.dropdown-toggle),
.input-group-btn:last-child > .btn-group:not(:last-child) > .btn {
  border-bottom-right-radius: 0;
  border-top-right-radius: 0;
}
.input-group-addon:first-child {
  border-right: 0;
}
.input-group .form-control:last-child,
.input-group-addon:last-child,
.input-group-btn:last-child > .btn,
.input-group-btn:last-child > .btn-group > .btn,
.input-group-btn:last-child > .dropdown-toggle,
.input-group-btn:first-child > .btn:not(:first-child),
.input-group-btn:first-child > .btn-group:not(:first-child) > .btn {
  border-bottom-left-radius: 0;
  border-top-left-radius: 0;
}
.input-group-addon:last-child {
  border-left: 0;
}
.input-group-btn {
  position: relative;
  font-size: 0;
  white-space: nowrap;
}
.input-group-btn > .btn {
  position: relative;
}
.input-group-btn > .btn + .btn {
  margin-left: -1px;
}
.input-group-btn > .btn:hover,
.input-group-btn > .btn:focus,
.input-group-btn > .btn:active {
  z-index: 2;
}
.input-group-btn:first-child > .btn,
.input-group-btn:first-child > .btn-group {
  margin-right: -1px;
}
.input-group-btn:last-child > .btn,
.input-group-btn:last-child > .btn-group {
  z-index: 2;
  margin-left: -1px;
}
.nav {
  margin-bottom: 0;
  padding-left: 0;
  list-style: none;
}
.nav > li {
  position: relative;
  display: block;
}
.nav > li > a {
  position: relative;
  display: block;
  padding: 10px 15px;
}
.nav > li > a:hover,
.nav > li > a:focus {
  text-decoration: none;
  background-color: #eeeeee;
}
.nav > li.disabled > a {
  color: #777777;
}
.nav > li.disabled > a:hover,
.nav > li.disabled > a:focus {
  color: #777777;
  text-decoration: none;
  background-color: transparent;
  cursor: not-allowed;
}
.nav .open > a,
.nav .open > a:hover,
.nav .open > a:focus {
  background-color: #eeeeee;
  border-color: #337ab7;
}
.nav .nav-divider {
  height: 1px;
  margin: 8px 0;
  overflow: hidden;
  background-color: #e5e5e5;
}
.nav > li > a > img {
  max-width: none;
}
.nav-tabs {
  border-bottom: 1px solid #ddd;
}
.nav-tabs > li {
  float: left;
  margin-bottom: -1px;
}
.nav-tabs > li > a {
  margin-right: 2px;
  line-height: 1.42857143;
  border: 1px solid transparent;
  border-radius: 2px 2px 0 0;
}
.nav-tabs > li > a:hover {
  border-color: #eeeeee #eeeeee #ddd;
}
.nav-tabs > li.active > a,
.nav-tabs > li.active > a:hover,
.nav-tabs > li.active > a:focus {
  color: #555555;
  background-color: #fff;
  border: 1px solid #ddd;
  border-bottom-color: transparent;
  cursor: default;
}
.nav-tabs.nav-justified {
  width: 100%;
  border-bottom: 0;
}
.nav-tabs.nav-justified > li {
  float: none;
}
.nav-tabs.nav-justified > li > a {
  text-align: center;
  margin-bottom: 5px;
}
.nav-tabs.nav-justified > .dropdown .dropdown-menu {
  top: auto;
  left: auto;
}
@media (min-width: 768px) {
  .nav-tabs.nav-justified > li {
    display: table-cell;
    width: 1%;
  }
  .nav-tabs.nav-justified > li > a {
    margin-bottom: 0;
  }
}
.nav-tabs.nav-justified > li > a {
  margin-right: 0;
  border-radius: 2px;
}
.nav-tabs.nav-justified > .active > a,
.nav-tabs.nav-justified > .active > a:hover,
.nav-tabs.nav-justified > .active > a:focus {
  border: 1px solid #ddd;
}
@media (min-width: 768px) {
  .nav-tabs.nav-justified > li > a {
    border-bottom: 1px solid #ddd;
    border-radius: 2px 2px 0 0;
  }
  .nav-tabs.nav-justified > .active > a,
  .nav-tabs.nav-justified > .active > a:hover,
  .nav-tabs.nav-justified > .active > a:focus {
    border-bottom-color: #fff;
  }
}
.nav-pills > li {
  float: left;
}
.nav-pills > li > a {
  border-radius: 2px;
}
.nav-pills > li + li {
  margin-left: 2px;
}
.nav-pills > li.active > a,
.nav-pills > li.active > a:hover,
.nav-pills > li.active > a:focus {
  color: #fff;
  background-color: #337ab7;
}
.nav-stacked > li {
  float: none;
}
.nav-stacked > li + li {
  margin-top: 2px;
  margin-left: 0;
}
.nav-justified {
  width: 100%;
}
.nav-justified > li {
  float: none;
}
.nav-justified > li > a {
  text-align: center;
  margin-bottom: 5px;
}
.nav-justified > .dropdown .dropdown-menu {
  top: auto;
  left: auto;
}
@media (min-width: 768px) {
  .nav-justified > li {
    display: table-cell;
    width: 1%;
  }
  .nav-justified > li > a {
    margin-bottom: 0;
  }
}
.nav-tabs-justified {
  border-bottom: 0;
}
.nav-tabs-justified > li > a {
  margin-right: 0;
  border-radius: 2px;
}
.nav-tabs-justified > .active > a,
.nav-tabs-justified > .active > a:hover,
.nav-tabs-justified > .active > a:focus {
  border: 1px solid #ddd;
}
@media (min-width: 768px) {
  .nav-tabs-justified > li > a {
    border-bottom: 1px solid #ddd;
    border-radius: 2px 2px 0 0;
  }
  .nav-tabs-justified > .active > a,
  .nav-tabs-justified > .active > a:hover,
  .nav-tabs-justified > .active > a:focus {
    border-bottom-color: #fff;
  }
}
.tab-content > .tab-pane {
  display: none;
}
.tab-content > .active {
  display: block;
}
.nav-tabs .dropdown-menu {
  margin-top: -1px;
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.navbar {
  position: relative;
  min-height: 30px;
  margin-bottom: 18px;
  border: 1px solid transparent;
}
@media (min-width: 541px) {
  .navbar {
    border-radius: 2px;
  }
}
@media (min-width: 541px) {
  .navbar-header {
    float: left;
  }
}
.navbar-collapse {
  overflow-x: visible;
  padding-right: 0px;
  padding-left: 0px;
  border-top: 1px solid transparent;
  box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.1);
  -webkit-overflow-scrolling: touch;
}
.navbar-collapse.in {
  overflow-y: auto;
}
@media (min-width: 541px) {
  .navbar-collapse {
    width: auto;
    border-top: 0;
    box-shadow: none;
  }
  .navbar-collapse.collapse {
    display: block !important;
    height: auto !important;
    padding-bottom: 0;
    overflow: visible !important;
  }
  .navbar-collapse.in {
    overflow-y: visible;
  }
  .navbar-fixed-top .navbar-collapse,
  .navbar-static-top .navbar-collapse,
  .navbar-fixed-bottom .navbar-collapse {
    padding-left: 0;
    padding-right: 0;
  }
}
.navbar-fixed-top .navbar-collapse,
.navbar-fixed-bottom .navbar-collapse {
  max-height: 340px;
}
@media (max-device-width: 540px) and (orientation: landscape) {
  .navbar-fixed-top .navbar-collapse,
  .navbar-fixed-bottom .navbar-collapse {
    max-height: 200px;
  }
}
.container > .navbar-header,
.container-fluid > .navbar-header,
.container > .navbar-collapse,
.container-fluid > .navbar-collapse {
  margin-right: 0px;
  margin-left: 0px;
}
@media (min-width: 541px) {
  .container > .navbar-header,
  .container-fluid > .navbar-header,
  .container > .navbar-collapse,
  .container-fluid > .navbar-collapse {
    margin-right: 0;
    margin-left: 0;
  }
}
.navbar-static-top {
  z-index: 1000;
  border-width: 0 0 1px;
}
@media (min-width: 541px) {
  .navbar-static-top {
    border-radius: 0;
  }
}
.navbar-fixed-top,
.navbar-fixed-bottom {
  position: fixed;
  right: 0;
  left: 0;
  z-index: 1030;
}
@media (min-width: 541px) {
  .navbar-fixed-top,
  .navbar-fixed-bottom {
    border-radius: 0;
  }
}
.navbar-fixed-top {
  top: 0;
  border-width: 0 0 1px;
}
.navbar-fixed-bottom {
  bottom: 0;
  margin-bottom: 0;
  border-width: 1px 0 0;
}
.navbar-brand {
  float: left;
  padding: 6px 0px;
  font-size: 17px;
  line-height: 18px;
  height: 30px;
}
.navbar-brand:hover,
.navbar-brand:focus {
  text-decoration: none;
}
.navbar-brand > img {
  display: block;
}
@media (min-width: 541px) {
  .navbar > .container .navbar-brand,
  .navbar > .container-fluid .navbar-brand {
    margin-left: 0px;
  }
}
.navbar-toggle {
  position: relative;
  float: right;
  margin-right: 0px;
  padding: 9px 10px;
  margin-top: -2px;
  margin-bottom: -2px;
  background-color: transparent;
  background-image: none;
  border: 1px solid transparent;
  border-radius: 2px;
}
.navbar-toggle:focus {
  outline: 0;
}
.navbar-toggle .icon-bar {
  display: block;
  width: 22px;
  height: 2px;
  border-radius: 1px;
}
.navbar-toggle .icon-bar + .icon-bar {
  margin-top: 4px;
}
@media (min-width: 541px) {
  .navbar-toggle {
    display: none;
  }
}
.navbar-nav {
  margin: 3px 0px;
}
.navbar-nav > li > a {
  padding-top: 10px;
  padding-bottom: 10px;
  line-height: 18px;
}
@media (max-width: 540px) {
  .navbar-nav .open .dropdown-menu {
    position: static;
    float: none;
    width: auto;
    margin-top: 0;
    background-color: transparent;
    border: 0;
    box-shadow: none;
  }
  .navbar-nav .open .dropdown-menu > li > a,
  .navbar-nav .open .dropdown-menu .dropdown-header {
    padding: 5px 15px 5px 25px;
  }
  .navbar-nav .open .dropdown-menu > li > a {
    line-height: 18px;
  }
  .navbar-nav .open .dropdown-menu > li > a:hover,
  .navbar-nav .open .dropdown-menu > li > a:focus {
    background-image: none;
  }
}
@media (min-width: 541px) {
  .navbar-nav {
    float: left;
    margin: 0;
  }
  .navbar-nav > li {
    float: left;
  }
  .navbar-nav > li > a {
    padding-top: 6px;
    padding-bottom: 6px;
  }
}
.navbar-form {
  margin-left: 0px;
  margin-right: 0px;
  padding: 10px 0px;
  border-top: 1px solid transparent;
  border-bottom: 1px solid transparent;
  -webkit-box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.1), 0 1px 0 rgba(255, 255, 255, 0.1);
  box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.1), 0 1px 0 rgba(255, 255, 255, 0.1);
  margin-top: -1px;
  margin-bottom: -1px;
}
@media (min-width: 768px) {
  .navbar-form .form-group {
    display: inline-block;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .navbar-form .form-control {
    display: inline-block;
    width: auto;
    vertical-align: middle;
  }
  .navbar-form .form-control-static {
    display: inline-block;
  }
  .navbar-form .input-group {
    display: inline-table;
    vertical-align: middle;
  }
  .navbar-form .input-group .input-group-addon,
  .navbar-form .input-group .input-group-btn,
  .navbar-form .input-group .form-control {
    width: auto;
  }
  .navbar-form .input-group > .form-control {
    width: 100%;
  }
  .navbar-form .control-label {
    margin-bottom: 0;
    vertical-align: middle;
  }
  .navbar-form .radio,
  .navbar-form .checkbox {
    display: inline-block;
    margin-top: 0;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .navbar-form .radio label,
  .navbar-form .checkbox label {
    padding-left: 0;
  }
  .navbar-form .radio input[type="radio"],
  .navbar-form .checkbox input[type="checkbox"] {
    position: relative;
    margin-left: 0;
  }
  .navbar-form .has-feedback .form-control-feedback {
    top: 0;
  }
}
@media (max-width: 540px) {
  .navbar-form .form-group {
    margin-bottom: 5px;
  }
  .navbar-form .form-group:last-child {
    margin-bottom: 0;
  }
}
@media (min-width: 541px) {
  .navbar-form {
    width: auto;
    border: 0;
    margin-left: 0;
    margin-right: 0;
    padding-top: 0;
    padding-bottom: 0;
    -webkit-box-shadow: none;
    box-shadow: none;
  }
}
.navbar-nav > li > .dropdown-menu {
  margin-top: 0;
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.navbar-fixed-bottom .navbar-nav > li > .dropdown-menu {
  margin-bottom: 0;
  border-top-right-radius: 2px;
  border-top-left-radius: 2px;
  border-bottom-right-radius: 0;
  border-bottom-left-radius: 0;
}
.navbar-btn {
  margin-top: -1px;
  margin-bottom: -1px;
}
.navbar-btn.btn-sm {
  margin-top: 0px;
  margin-bottom: 0px;
}
.navbar-btn.btn-xs {
  margin-top: 4px;
  margin-bottom: 4px;
}
.navbar-text {
  margin-top: 6px;
  margin-bottom: 6px;
}
@media (min-width: 541px) {
  .navbar-text {
    float: left;
    margin-left: 0px;
    margin-right: 0px;
  }
}
@media (min-width: 541px) {
  .navbar-left {
    float: left !important;
    float: left;
  }
  .navbar-right {
    float: right !important;
    float: right;
    margin-right: 0px;
  }
  .navbar-right ~ .navbar-right {
    margin-right: 0;
  }
}
.navbar-default {
  background-color: #f8f8f8;
  border-color: #e7e7e7;
}
.navbar-default .navbar-brand {
  color: #777;
}
.navbar-default .navbar-brand:hover,
.navbar-default .navbar-brand:focus {
  color: #5e5e5e;
  background-color: transparent;
}
.navbar-default .navbar-text {
  color: #777;
}
.navbar-default .navbar-nav > li > a {
  color: #777;
}
.navbar-default .navbar-nav > li > a:hover,
.navbar-default .navbar-nav > li > a:focus {
  color: #333;
  background-color: transparent;
}
.navbar-default .navbar-nav > .active > a,
.navbar-default .navbar-nav > .active > a:hover,
.navbar-default .navbar-nav > .active > a:focus {
  color: #555;
  background-color: #e7e7e7;
}
.navbar-default .navbar-nav > .disabled > a,
.navbar-default .navbar-nav > .disabled > a:hover,
.navbar-default .navbar-nav > .disabled > a:focus {
  color: #ccc;
  background-color: transparent;
}
.navbar-default .navbar-toggle {
  border-color: #ddd;
}
.navbar-default .navbar-toggle:hover,
.navbar-default .navbar-toggle:focus {
  background-color: #ddd;
}
.navbar-default .navbar-toggle .icon-bar {
  background-color: #888;
}
.navbar-default .navbar-collapse,
.navbar-default .navbar-form {
  border-color: #e7e7e7;
}
.navbar-default .navbar-nav > .open > a,
.navbar-default .navbar-nav > .open > a:hover,
.navbar-default .navbar-nav > .open > a:focus {
  background-color: #e7e7e7;
  color: #555;
}
@media (max-width: 540px) {
  .navbar-default .navbar-nav .open .dropdown-menu > li > a {
    color: #777;
  }
  .navbar-default .navbar-nav .open .dropdown-menu > li > a:hover,
  .navbar-default .navbar-nav .open .dropdown-menu > li > a:focus {
    color: #333;
    background-color: transparent;
  }
  .navbar-default .navbar-nav .open .dropdown-menu > .active > a,
  .navbar-default .navbar-nav .open .dropdown-menu > .active > a:hover,
  .navbar-default .navbar-nav .open .dropdown-menu > .active > a:focus {
    color: #555;
    background-color: #e7e7e7;
  }
  .navbar-default .navbar-nav .open .dropdown-menu > .disabled > a,
  .navbar-default .navbar-nav .open .dropdown-menu > .disabled > a:hover,
  .navbar-default .navbar-nav .open .dropdown-menu > .disabled > a:focus {
    color: #ccc;
    background-color: transparent;
  }
}
.navbar-default .navbar-link {
  color: #777;
}
.navbar-default .navbar-link:hover {
  color: #333;
}
.navbar-default .btn-link {
  color: #777;
}
.navbar-default .btn-link:hover,
.navbar-default .btn-link:focus {
  color: #333;
}
.navbar-default .btn-link[disabled]:hover,
fieldset[disabled] .navbar-default .btn-link:hover,
.navbar-default .btn-link[disabled]:focus,
fieldset[disabled] .navbar-default .btn-link:focus {
  color: #ccc;
}
.navbar-inverse {
  background-color: #222;
  border-color: #080808;
}
.navbar-inverse .navbar-brand {
  color: #9d9d9d;
}
.navbar-inverse .navbar-brand:hover,
.navbar-inverse .navbar-brand:focus {
  color: #fff;
  background-color: transparent;
}
.navbar-inverse .navbar-text {
  color: #9d9d9d;
}
.navbar-inverse .navbar-nav > li > a {
  color: #9d9d9d;
}
.navbar-inverse .navbar-nav > li > a:hover,
.navbar-inverse .navbar-nav > li > a:focus {
  color: #fff;
  background-color: transparent;
}
.navbar-inverse .navbar-nav > .active > a,
.navbar-inverse .navbar-nav > .active > a:hover,
.navbar-inverse .navbar-nav > .active > a:focus {
  color: #fff;
  background-color: #080808;
}
.navbar-inverse .navbar-nav > .disabled > a,
.navbar-inverse .navbar-nav > .disabled > a:hover,
.navbar-inverse .navbar-nav > .disabled > a:focus {
  color: #444;
  background-color: transparent;
}
.navbar-inverse .navbar-toggle {
  border-color: #333;
}
.navbar-inverse .navbar-toggle:hover,
.navbar-inverse .navbar-toggle:focus {
  background-color: #333;
}
.navbar-inverse .navbar-toggle .icon-bar {
  background-color: #fff;
}
.navbar-inverse .navbar-collapse,
.navbar-inverse .navbar-form {
  border-color: #101010;
}
.navbar-inverse .navbar-nav > .open > a,
.navbar-inverse .navbar-nav > .open > a:hover,
.navbar-inverse .navbar-nav > .open > a:focus {
  background-color: #080808;
  color: #fff;
}
@media (max-width: 540px) {
  .navbar-inverse .navbar-nav .open .dropdown-menu > .dropdown-header {
    border-color: #080808;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu .divider {
    background-color: #080808;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > li > a {
    color: #9d9d9d;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > li > a:hover,
  .navbar-inverse .navbar-nav .open .dropdown-menu > li > a:focus {
    color: #fff;
    background-color: transparent;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > .active > a,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .active > a:hover,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .active > a:focus {
    color: #fff;
    background-color: #080808;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > .disabled > a,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .disabled > a:hover,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .disabled > a:focus {
    color: #444;
    background-color: transparent;
  }
}
.navbar-inverse .navbar-link {
  color: #9d9d9d;
}
.navbar-inverse .navbar-link:hover {
  color: #fff;
}
.navbar-inverse .btn-link {
  color: #9d9d9d;
}
.navbar-inverse .btn-link:hover,
.navbar-inverse .btn-link:focus {
  color: #fff;
}
.navbar-inverse .btn-link[disabled]:hover,
fieldset[disabled] .navbar-inverse .btn-link:hover,
.navbar-inverse .btn-link[disabled]:focus,
fieldset[disabled] .navbar-inverse .btn-link:focus {
  color: #444;
}
.breadcrumb {
  padding: 8px 15px;
  margin-bottom: 18px;
  list-style: none;
  background-color: #f5f5f5;
  border-radius: 2px;
}
.breadcrumb > li {
  display: inline-block;
}
.breadcrumb > li + li:before {
  content: "/\00a0";
  padding: 0 5px;
  color: #5e5e5e;
}
.breadcrumb > .active {
  color: #777777;
}
.pagination {
  display: inline-block;
  padding-left: 0;
  margin: 18px 0;
  border-radius: 2px;
}
.pagination > li {
  display: inline;
}
.pagination > li > a,
.pagination > li > span {
  position: relative;
  float: left;
  padding: 6px 12px;
  line-height: 1.42857143;
  text-decoration: none;
  color: #337ab7;
  background-color: #fff;
  border: 1px solid #ddd;
  margin-left: -1px;
}
.pagination > li:first-child > a,
.pagination > li:first-child > span {
  margin-left: 0;
  border-bottom-left-radius: 2px;
  border-top-left-radius: 2px;
}
.pagination > li:last-child > a,
.pagination > li:last-child > span {
  border-bottom-right-radius: 2px;
  border-top-right-radius: 2px;
}
.pagination > li > a:hover,
.pagination > li > span:hover,
.pagination > li > a:focus,
.pagination > li > span:focus {
  z-index: 2;
  color: #23527c;
  background-color: #eeeeee;
  border-color: #ddd;
}
.pagination > .active > a,
.pagination > .active > span,
.pagination > .active > a:hover,
.pagination > .active > span:hover,
.pagination > .active > a:focus,
.pagination > .active > span:focus {
  z-index: 3;
  color: #fff;
  background-color: #337ab7;
  border-color: #337ab7;
  cursor: default;
}
.pagination > .disabled > span,
.pagination > .disabled > span:hover,
.pagination > .disabled > span:focus,
.pagination > .disabled > a,
.pagination > .disabled > a:hover,
.pagination > .disabled > a:focus {
  color: #777777;
  background-color: #fff;
  border-color: #ddd;
  cursor: not-allowed;
}
.pagination-lg > li > a,
.pagination-lg > li > span {
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
}
.pagination-lg > li:first-child > a,
.pagination-lg > li:first-child > span {
  border-bottom-left-radius: 3px;
  border-top-left-radius: 3px;
}
.pagination-lg > li:last-child > a,
.pagination-lg > li:last-child > span {
  border-bottom-right-radius: 3px;
  border-top-right-radius: 3px;
}
.pagination-sm > li > a,
.pagination-sm > li > span {
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
}
.pagination-sm > li:first-child > a,
.pagination-sm > li:first-child > span {
  border-bottom-left-radius: 1px;
  border-top-left-radius: 1px;
}
.pagination-sm > li:last-child > a,
.pagination-sm > li:last-child > span {
  border-bottom-right-radius: 1px;
  border-top-right-radius: 1px;
}
.pager {
  padding-left: 0;
  margin: 18px 0;
  list-style: none;
  text-align: center;
}
.pager li {
  display: inline;
}
.pager li > a,
.pager li > span {
  display: inline-block;
  padding: 5px 14px;
  background-color: #fff;
  border: 1px solid #ddd;
  border-radius: 15px;
}
.pager li > a:hover,
.pager li > a:focus {
  text-decoration: none;
  background-color: #eeeeee;
}
.pager .next > a,
.pager .next > span {
  float: right;
}
.pager .previous > a,
.pager .previous > span {
  float: left;
}
.pager .disabled > a,
.pager .disabled > a:hover,
.pager .disabled > a:focus,
.pager .disabled > span {
  color: #777777;
  background-color: #fff;
  cursor: not-allowed;
}
.label {
  display: inline;
  padding: .2em .6em .3em;
  font-size: 75%;
  font-weight: bold;
  line-height: 1;
  color: #fff;
  text-align: center;
  white-space: nowrap;
  vertical-align: baseline;
  border-radius: .25em;
}
a.label:hover,
a.label:focus {
  color: #fff;
  text-decoration: none;
  cursor: pointer;
}
.label:empty {
  display: none;
}
.btn .label {
  position: relative;
  top: -1px;
}
.label-default {
  background-color: #777777;
}
.label-default[href]:hover,
.label-default[href]:focus {
  background-color: #5e5e5e;
}
.label-primary {
  background-color: #337ab7;
}
.label-primary[href]:hover,
.label-primary[href]:focus {
  background-color: #286090;
}
.label-success {
  background-color: #5cb85c;
}
.label-success[href]:hover,
.label-success[href]:focus {
  background-color: #449d44;
}
.label-info {
  background-color: #5bc0de;
}
.label-info[href]:hover,
.label-info[href]:focus {
  background-color: #31b0d5;
}
.label-warning {
  background-color: #f0ad4e;
}
.label-warning[href]:hover,
.label-warning[href]:focus {
  background-color: #ec971f;
}
.label-danger {
  background-color: #d9534f;
}
.label-danger[href]:hover,
.label-danger[href]:focus {
  background-color: #c9302c;
}
.badge {
  display: inline-block;
  min-width: 10px;
  padding: 3px 7px;
  font-size: 12px;
  font-weight: bold;
  color: #fff;
  line-height: 1;
  vertical-align: middle;
  white-space: nowrap;
  text-align: center;
  background-color: #777777;
  border-radius: 10px;
}
.badge:empty {
  display: none;
}
.btn .badge {
  position: relative;
  top: -1px;
}
.btn-xs .badge,
.btn-group-xs > .btn .badge {
  top: 0;
  padding: 1px 5px;
}
a.badge:hover,
a.badge:focus {
  color: #fff;
  text-decoration: none;
  cursor: pointer;
}
.list-group-item.active > .badge,
.nav-pills > .active > a > .badge {
  color: #337ab7;
  background-color: #fff;
}
.list-group-item > .badge {
  float: right;
}
.list-group-item > .badge + .badge {
  margin-right: 5px;
}
.nav-pills > li > a > .badge {
  margin-left: 3px;
}
.jumbotron {
  padding-top: 30px;
  padding-bottom: 30px;
  margin-bottom: 30px;
  color: inherit;
  background-color: #eeeeee;
}
.jumbotron h1,
.jumbotron .h1 {
  color: inherit;
}
.jumbotron p {
  margin-bottom: 15px;
  font-size: 20px;
  font-weight: 200;
}
.jumbotron > hr {
  border-top-color: #d5d5d5;
}
.container .jumbotron,
.container-fluid .jumbotron {
  border-radius: 3px;
  padding-left: 0px;
  padding-right: 0px;
}
.jumbotron .container {
  max-width: 100%;
}
@media screen and (min-width: 768px) {
  .jumbotron {
    padding-top: 48px;
    padding-bottom: 48px;
  }
  .container .jumbotron,
  .container-fluid .jumbotron {
    padding-left: 60px;
    padding-right: 60px;
  }
  .jumbotron h1,
  .jumbotron .h1 {
    font-size: 59px;
  }
}
.thumbnail {
  display: block;
  padding: 4px;
  margin-bottom: 18px;
  line-height: 1.42857143;
  background-color: #fff;
  border: 1px solid #ddd;
  border-radius: 2px;
  -webkit-transition: border 0.2s ease-in-out;
  -o-transition: border 0.2s ease-in-out;
  transition: border 0.2s ease-in-out;
}
.thumbnail > img,
.thumbnail a > img {
  margin-left: auto;
  margin-right: auto;
}
a.thumbnail:hover,
a.thumbnail:focus,
a.thumbnail.active {
  border-color: #337ab7;
}
.thumbnail .caption {
  padding: 9px;
  color: #000;
}
.alert {
  padding: 15px;
  margin-bottom: 18px;
  border: 1px solid transparent;
  border-radius: 2px;
}
.alert h4 {
  margin-top: 0;
  color: inherit;
}
.alert .alert-link {
  font-weight: bold;
}
.alert > p,
.alert > ul {
  margin-bottom: 0;
}
.alert > p + p {
  margin-top: 5px;
}
.alert-dismissable,
.alert-dismissible {
  padding-right: 35px;
}
.alert-dismissable .close,
.alert-dismissible .close {
  position: relative;
  top: -2px;
  right: -21px;
  color: inherit;
}
.alert-success {
  background-color: #dff0d8;
  border-color: #d6e9c6;
  color: #3c763d;
}
.alert-success hr {
  border-top-color: #c9e2b3;
}
.alert-success .alert-link {
  color: #2b542c;
}
.alert-info {
  background-color: #d9edf7;
  border-color: #bce8f1;
  color: #31708f;
}
.alert-info hr {
  border-top-color: #a6e1ec;
}
.alert-info .alert-link {
  color: #245269;
}
.alert-warning {
  background-color: #fcf8e3;
  border-color: #faebcc;
  color: #8a6d3b;
}
.alert-warning hr {
  border-top-color: #f7e1b5;
}
.alert-warning .alert-link {
  color: #66512c;
}
.alert-danger {
  background-color: #f2dede;
  border-color: #ebccd1;
  color: #a94442;
}
.alert-danger hr {
  border-top-color: #e4b9c0;
}
.alert-danger .alert-link {
  color: #843534;
}
@-webkit-keyframes progress-bar-stripes {
  from {
    background-position: 40px 0;
  }
  to {
    background-position: 0 0;
  }
}
@keyframes progress-bar-stripes {
  from {
    background-position: 40px 0;
  }
  to {
    background-position: 0 0;
  }
}
.progress {
  overflow: hidden;
  height: 18px;
  margin-bottom: 18px;
  background-color: #f5f5f5;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 2px rgba(0, 0, 0, 0.1);
  box-shadow: inset 0 1px 2px rgba(0, 0, 0, 0.1);
}
.progress-bar {
  float: left;
  width: 0%;
  height: 100%;
  font-size: 12px;
  line-height: 18px;
  color: #fff;
  text-align: center;
  background-color: #337ab7;
  -webkit-box-shadow: inset 0 -1px 0 rgba(0, 0, 0, 0.15);
  box-shadow: inset 0 -1px 0 rgba(0, 0, 0, 0.15);
  -webkit-transition: width 0.6s ease;
  -o-transition: width 0.6s ease;
  transition: width 0.6s ease;
}
.progress-striped .progress-bar,
.progress-bar-striped {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-size: 40px 40px;
}
.progress.active .progress-bar,
.progress-bar.active {
  -webkit-animation: progress-bar-stripes 2s linear infinite;
  -o-animation: progress-bar-stripes 2s linear infinite;
  animation: progress-bar-stripes 2s linear infinite;
}
.progress-bar-success {
  background-color: #5cb85c;
}
.progress-striped .progress-bar-success {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.progress-bar-info {
  background-color: #5bc0de;
}
.progress-striped .progress-bar-info {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.progress-bar-warning {
  background-color: #f0ad4e;
}
.progress-striped .progress-bar-warning {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.progress-bar-danger {
  background-color: #d9534f;
}
.progress-striped .progress-bar-danger {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.media {
  margin-top: 15px;
}
.media:first-child {
  margin-top: 0;
}
.media,
.media-body {
  zoom: 1;
  overflow: hidden;
}
.media-body {
  width: 10000px;
}
.media-object {
  display: block;
}
.media-object.img-thumbnail {
  max-width: none;
}
.media-right,
.media > .pull-right {
  padding-left: 10px;
}
.media-left,
.media > .pull-left {
  padding-right: 10px;
}
.media-left,
.media-right,
.media-body {
  display: table-cell;
  vertical-align: top;
}
.media-middle {
  vertical-align: middle;
}
.media-bottom {
  vertical-align: bottom;
}
.media-heading {
  margin-top: 0;
  margin-bottom: 5px;
}
.media-list {
  padding-left: 0;
  list-style: none;
}
.list-group {
  margin-bottom: 20px;
  padding-left: 0;
}
.list-group-item {
  position: relative;
  display: block;
  padding: 10px 15px;
  margin-bottom: -1px;
  background-color: #fff;
  border: 1px solid #ddd;
}
.list-group-item:first-child {
  border-top-right-radius: 2px;
  border-top-left-radius: 2px;
}
.list-group-item:last-child {
  margin-bottom: 0;
  border-bottom-right-radius: 2px;
  border-bottom-left-radius: 2px;
}
a.list-group-item,
button.list-group-item {
  color: #555;
}
a.list-group-item .list-group-item-heading,
button.list-group-item .list-group-item-heading {
  color: #333;
}
a.list-group-item:hover,
button.list-group-item:hover,
a.list-group-item:focus,
button.list-group-item:focus {
  text-decoration: none;
  color: #555;
  background-color: #f5f5f5;
}
button.list-group-item {
  width: 100%;
  text-align: left;
}
.list-group-item.disabled,
.list-group-item.disabled:hover,
.list-group-item.disabled:focus {
  background-color: #eeeeee;
  color: #777777;
  cursor: not-allowed;
}
.list-group-item.disabled .list-group-item-heading,
.list-group-item.disabled:hover .list-group-item-heading,
.list-group-item.disabled:focus .list-group-item-heading {
  color: inherit;
}
.list-group-item.disabled .list-group-item-text,
.list-group-item.disabled:hover .list-group-item-text,
.list-group-item.disabled:focus .list-group-item-text {
  color: #777777;
}
.list-group-item.active,
.list-group-item.active:hover,
.list-group-item.active:focus {
  z-index: 2;
  color: #fff;
  background-color: #337ab7;
  border-color: #337ab7;
}
.list-group-item.active .list-group-item-heading,
.list-group-item.active:hover .list-group-item-heading,
.list-group-item.active:focus .list-group-item-heading,
.list-group-item.active .list-group-item-heading > small,
.list-group-item.active:hover .list-group-item-heading > small,
.list-group-item.active:focus .list-group-item-heading > small,
.list-group-item.active .list-group-item-heading > .small,
.list-group-item.active:hover .list-group-item-heading > .small,
.list-group-item.active:focus .list-group-item-heading > .small {
  color: inherit;
}
.list-group-item.active .list-group-item-text,
.list-group-item.active:hover .list-group-item-text,
.list-group-item.active:focus .list-group-item-text {
  color: #c7ddef;
}
.list-group-item-success {
  color: #3c763d;
  background-color: #dff0d8;
}
a.list-group-item-success,
button.list-group-item-success {
  color: #3c763d;
}
a.list-group-item-success .list-group-item-heading,
button.list-group-item-success .list-group-item-heading {
  color: inherit;
}
a.list-group-item-success:hover,
button.list-group-item-success:hover,
a.list-group-item-success:focus,
button.list-group-item-success:focus {
  color: #3c763d;
  background-color: #d0e9c6;
}
a.list-group-item-success.active,
button.list-group-item-success.active,
a.list-group-item-success.active:hover,
button.list-group-item-success.active:hover,
a.list-group-item-success.active:focus,
button.list-group-item-success.active:focus {
  color: #fff;
  background-color: #3c763d;
  border-color: #3c763d;
}
.list-group-item-info {
  color: #31708f;
  background-color: #d9edf7;
}
a.list-group-item-info,
button.list-group-item-info {
  color: #31708f;
}
a.list-group-item-info .list-group-item-heading,
button.list-group-item-info .list-group-item-heading {
  color: inherit;
}
a.list-group-item-info:hover,
button.list-group-item-info:hover,
a.list-group-item-info:focus,
button.list-group-item-info:focus {
  color: #31708f;
  background-color: #c4e3f3;
}
a.list-group-item-info.active,
button.list-group-item-info.active,
a.list-group-item-info.active:hover,
button.list-group-item-info.active:hover,
a.list-group-item-info.active:focus,
button.list-group-item-info.active:focus {
  color: #fff;
  background-color: #31708f;
  border-color: #31708f;
}
.list-group-item-warning {
  color: #8a6d3b;
  background-color: #fcf8e3;
}
a.list-group-item-warning,
button.list-group-item-warning {
  color: #8a6d3b;
}
a.list-group-item-warning .list-group-item-heading,
button.list-group-item-warning .list-group-item-heading {
  color: inherit;
}
a.list-group-item-warning:hover,
button.list-group-item-warning:hover,
a.list-group-item-warning:focus,
button.list-group-item-warning:focus {
  color: #8a6d3b;
  background-color: #faf2cc;
}
a.list-group-item-warning.active,
button.list-group-item-warning.active,
a.list-group-item-warning.active:hover,
button.list-group-item-warning.active:hover,
a.list-group-item-warning.active:focus,
button.list-group-item-warning.active:focus {
  color: #fff;
  background-color: #8a6d3b;
  border-color: #8a6d3b;
}
.list-group-item-danger {
  color: #a94442;
  background-color: #f2dede;
}
a.list-group-item-danger,
button.list-group-item-danger {
  color: #a94442;
}
a.list-group-item-danger .list-group-item-heading,
button.list-group-item-danger .list-group-item-heading {
  color: inherit;
}
a.list-group-item-danger:hover,
button.list-group-item-danger:hover,
a.list-group-item-danger:focus,
button.list-group-item-danger:focus {
  color: #a94442;
  background-color: #ebcccc;
}
a.list-group-item-danger.active,
button.list-group-item-danger.active,
a.list-group-item-danger.active:hover,
button.list-group-item-danger.active:hover,
a.list-group-item-danger.active:focus,
button.list-group-item-danger.active:focus {
  color: #fff;
  background-color: #a94442;
  border-color: #a94442;
}
.list-group-item-heading {
  margin-top: 0;
  margin-bottom: 5px;
}
.list-group-item-text {
  margin-bottom: 0;
  line-height: 1.3;
}
.panel {
  margin-bottom: 18px;
  background-color: #fff;
  border: 1px solid transparent;
  border-radius: 2px;
  -webkit-box-shadow: 0 1px 1px rgba(0, 0, 0, 0.05);
  box-shadow: 0 1px 1px rgba(0, 0, 0, 0.05);
}
.panel-body {
  padding: 15px;
}
.panel-heading {
  padding: 10px 15px;
  border-bottom: 1px solid transparent;
  border-top-right-radius: 1px;
  border-top-left-radius: 1px;
}
.panel-heading > .dropdown .dropdown-toggle {
  color: inherit;
}
.panel-title {
  margin-top: 0;
  margin-bottom: 0;
  font-size: 15px;
  color: inherit;
}
.panel-title > a,
.panel-title > small,
.panel-title > .small,
.panel-title > small > a,
.panel-title > .small > a {
  color: inherit;
}
.panel-footer {
  padding: 10px 15px;
  background-color: #f5f5f5;
  border-top: 1px solid #ddd;
  border-bottom-right-radius: 1px;
  border-bottom-left-radius: 1px;
}
.panel > .list-group,
.panel > .panel-collapse > .list-group {
  margin-bottom: 0;
}
.panel > .list-group .list-group-item,
.panel > .panel-collapse > .list-group .list-group-item {
  border-width: 1px 0;
  border-radius: 0;
}
.panel > .list-group:first-child .list-group-item:first-child,
.panel > .panel-collapse > .list-group:first-child .list-group-item:first-child {
  border-top: 0;
  border-top-right-radius: 1px;
  border-top-left-radius: 1px;
}
.panel > .list-group:last-child .list-group-item:last-child,
.panel > .panel-collapse > .list-group:last-child .list-group-item:last-child {
  border-bottom: 0;
  border-bottom-right-radius: 1px;
  border-bottom-left-radius: 1px;
}
.panel > .panel-heading + .panel-collapse > .list-group .list-group-item:first-child {
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.panel-heading + .list-group .list-group-item:first-child {
  border-top-width: 0;
}
.list-group + .panel-footer {
  border-top-width: 0;
}
.panel > .table,
.panel > .table-responsive > .table,
.panel > .panel-collapse > .table {
  margin-bottom: 0;
}
.panel > .table caption,
.panel > .table-responsive > .table caption,
.panel > .panel-collapse > .table caption {
  padding-left: 15px;
  padding-right: 15px;
}
.panel > .table:first-child,
.panel > .table-responsive:first-child > .table:first-child {
  border-top-right-radius: 1px;
  border-top-left-radius: 1px;
}
.panel > .table:first-child > thead:first-child > tr:first-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child,
.panel > .table:first-child > tbody:first-child > tr:first-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child {
  border-top-left-radius: 1px;
  border-top-right-radius: 1px;
}
.panel > .table:first-child > thead:first-child > tr:first-child td:first-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child td:first-child,
.panel > .table:first-child > tbody:first-child > tr:first-child td:first-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child td:first-child,
.panel > .table:first-child > thead:first-child > tr:first-child th:first-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child th:first-child,
.panel > .table:first-child > tbody:first-child > tr:first-child th:first-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child th:first-child {
  border-top-left-radius: 1px;
}
.panel > .table:first-child > thead:first-child > tr:first-child td:last-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child td:last-child,
.panel > .table:first-child > tbody:first-child > tr:first-child td:last-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child td:last-child,
.panel > .table:first-child > thead:first-child > tr:first-child th:last-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child th:last-child,
.panel > .table:first-child > tbody:first-child > tr:first-child th:last-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child th:last-child {
  border-top-right-radius: 1px;
}
.panel > .table:last-child,
.panel > .table-responsive:last-child > .table:last-child {
  border-bottom-right-radius: 1px;
  border-bottom-left-radius: 1px;
}
.panel > .table:last-child > tbody:last-child > tr:last-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child {
  border-bottom-left-radius: 1px;
  border-bottom-right-radius: 1px;
}
.panel > .table:last-child > tbody:last-child > tr:last-child td:first-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child td:first-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child td:first-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child td:first-child,
.panel > .table:last-child > tbody:last-child > tr:last-child th:first-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child th:first-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child th:first-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child th:first-child {
  border-bottom-left-radius: 1px;
}
.panel > .table:last-child > tbody:last-child > tr:last-child td:last-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child td:last-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child td:last-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child td:last-child,
.panel > .table:last-child > tbody:last-child > tr:last-child th:last-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child th:last-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child th:last-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child th:last-child {
  border-bottom-right-radius: 1px;
}
.panel > .panel-body + .table,
.panel > .panel-body + .table-responsive,
.panel > .table + .panel-body,
.panel > .table-responsive + .panel-body {
  border-top: 1px solid #ddd;
}
.panel > .table > tbody:first-child > tr:first-child th,
.panel > .table > tbody:first-child > tr:first-child td {
  border-top: 0;
}
.panel > .table-bordered,
.panel > .table-responsive > .table-bordered {
  border: 0;
}
.panel > .table-bordered > thead > tr > th:first-child,
.panel > .table-responsive > .table-bordered > thead > tr > th:first-child,
.panel > .table-bordered > tbody > tr > th:first-child,
.panel > .table-responsive > .table-bordered > tbody > tr > th:first-child,
.panel > .table-bordered > tfoot > tr > th:first-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > th:first-child,
.panel > .table-bordered > thead > tr > td:first-child,
.panel > .table-responsive > .table-bordered > thead > tr > td:first-child,
.panel > .table-bordered > tbody > tr > td:first-child,
.panel > .table-responsive > .table-bordered > tbody > tr > td:first-child,
.panel > .table-bordered > tfoot > tr > td:first-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > td:first-child {
  border-left: 0;
}
.panel > .table-bordered > thead > tr > th:last-child,
.panel > .table-responsive > .table-bordered > thead > tr > th:last-child,
.panel > .table-bordered > tbody > tr > th:last-child,
.panel > .table-responsive > .table-bordered > tbody > tr > th:last-child,
.panel > .table-bordered > tfoot > tr > th:last-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > th:last-child,
.panel > .table-bordered > thead > tr > td:last-child,
.panel > .table-responsive > .table-bordered > thead > tr > td:last-child,
.panel > .table-bordered > tbody > tr > td:last-child,
.panel > .table-responsive > .table-bordered > tbody > tr > td:last-child,
.panel > .table-bordered > tfoot > tr > td:last-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > td:last-child {
  border-right: 0;
}
.panel > .table-bordered > thead > tr:first-child > td,
.panel > .table-responsive > .table-bordered > thead > tr:first-child > td,
.panel > .table-bordered > tbody > tr:first-child > td,
.panel > .table-responsive > .table-bordered > tbody > tr:first-child > td,
.panel > .table-bordered > thead > tr:first-child > th,
.panel > .table-responsive > .table-bordered > thead > tr:first-child > th,
.panel > .table-bordered > tbody > tr:first-child > th,
.panel > .table-responsive > .table-bordered > tbody > tr:first-child > th {
  border-bottom: 0;
}
.panel > .table-bordered > tbody > tr:last-child > td,
.panel > .table-responsive > .table-bordered > tbody > tr:last-child > td,
.panel > .table-bordered > tfoot > tr:last-child > td,
.panel > .table-responsive > .table-bordered > tfoot > tr:last-child > td,
.panel > .table-bordered > tbody > tr:last-child > th,
.panel > .table-responsive > .table-bordered > tbody > tr:last-child > th,
.panel > .table-bordered > tfoot > tr:last-child > th,
.panel > .table-responsive > .table-bordered > tfoot > tr:last-child > th {
  border-bottom: 0;
}
.panel > .table-responsive {
  border: 0;
  margin-bottom: 0;
}
.panel-group {
  margin-bottom: 18px;
}
.panel-group .panel {
  margin-bottom: 0;
  border-radius: 2px;
}
.panel-group .panel + .panel {
  margin-top: 5px;
}
.panel-group .panel-heading {
  border-bottom: 0;
}
.panel-group .panel-heading + .panel-collapse > .panel-body,
.panel-group .panel-heading + .panel-collapse > .list-group {
  border-top: 1px solid #ddd;
}
.panel-group .panel-footer {
  border-top: 0;
}
.panel-group .panel-footer + .panel-collapse .panel-body {
  border-bottom: 1px solid #ddd;
}
.panel-default {
  border-color: #ddd;
}
.panel-default > .panel-heading {
  color: #333333;
  background-color: #f5f5f5;
  border-color: #ddd;
}
.panel-default > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #ddd;
}
.panel-default > .panel-heading .badge {
  color: #f5f5f5;
  background-color: #333333;
}
.panel-default > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #ddd;
}
.panel-primary {
  border-color: #337ab7;
}
.panel-primary > .panel-heading {
  color: #fff;
  background-color: #337ab7;
  border-color: #337ab7;
}
.panel-primary > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #337ab7;
}
.panel-primary > .panel-heading .badge {
  color: #337ab7;
  background-color: #fff;
}
.panel-primary > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #337ab7;
}
.panel-success {
  border-color: #d6e9c6;
}
.panel-success > .panel-heading {
  color: #3c763d;
  background-color: #dff0d8;
  border-color: #d6e9c6;
}
.panel-success > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #d6e9c6;
}
.panel-success > .panel-heading .badge {
  color: #dff0d8;
  background-color: #3c763d;
}
.panel-success > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #d6e9c6;
}
.panel-info {
  border-color: #bce8f1;
}
.panel-info > .panel-heading {
  color: #31708f;
  background-color: #d9edf7;
  border-color: #bce8f1;
}
.panel-info > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #bce8f1;
}
.panel-info > .panel-heading .badge {
  color: #d9edf7;
  background-color: #31708f;
}
.panel-info > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #bce8f1;
}
.panel-warning {
  border-color: #faebcc;
}
.panel-warning > .panel-heading {
  color: #8a6d3b;
  background-color: #fcf8e3;
  border-color: #faebcc;
}
.panel-warning > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #faebcc;
}
.panel-warning > .panel-heading .badge {
  color: #fcf8e3;
  background-color: #8a6d3b;
}
.panel-warning > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #faebcc;
}
.panel-danger {
  border-color: #ebccd1;
}
.panel-danger > .panel-heading {
  color: #a94442;
  background-color: #f2dede;
  border-color: #ebccd1;
}
.panel-danger > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #ebccd1;
}
.panel-danger > .panel-heading .badge {
  color: #f2dede;
  background-color: #a94442;
}
.panel-danger > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #ebccd1;
}
.embed-responsive {
  position: relative;
  display: block;
  height: 0;
  padding: 0;
  overflow: hidden;
}
.embed-responsive .embed-responsive-item,
.embed-responsive iframe,
.embed-responsive embed,
.embed-responsive object,
.embed-responsive video {
  position: absolute;
  top: 0;
  left: 0;
  bottom: 0;
  height: 100%;
  width: 100%;
  border: 0;
}
.embed-responsive-16by9 {
  padding-bottom: 56.25%;
}
.embed-responsive-4by3 {
  padding-bottom: 75%;
}
.well {
  min-height: 20px;
  padding: 19px;
  margin-bottom: 20px;
  background-color: #f5f5f5;
  border: 1px solid #e3e3e3;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.05);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.05);
}
.well blockquote {
  border-color: #ddd;
  border-color: rgba(0, 0, 0, 0.15);
}
.well-lg {
  padding: 24px;
  border-radius: 3px;
}
.well-sm {
  padding: 9px;
  border-radius: 1px;
}
.close {
  float: right;
  font-size: 19.5px;
  font-weight: bold;
  line-height: 1;
  color: #000;
  text-shadow: 0 1px 0 #fff;
  opacity: 0.2;
  filter: alpha(opacity=20);
}
.close:hover,
.close:focus {
  color: #000;
  text-decoration: none;
  cursor: pointer;
  opacity: 0.5;
  filter: alpha(opacity=50);
}
button.close {
  padding: 0;
  cursor: pointer;
  background: transparent;
  border: 0;
  -webkit-appearance: none;
}
.modal-open {
  overflow: hidden;
}
.modal {
  display: none;
  overflow: hidden;
  position: fixed;
  top: 0;
  right: 0;
  bottom: 0;
  left: 0;
  z-index: 1050;
  -webkit-overflow-scrolling: touch;
  outline: 0;
}
.modal.fade .modal-dialog {
  -webkit-transform: translate(0, -25%);
  -ms-transform: translate(0, -25%);
  -o-transform: translate(0, -25%);
  transform: translate(0, -25%);
  -webkit-transition: -webkit-transform 0.3s ease-out;
  -moz-transition: -moz-transform 0.3s ease-out;
  -o-transition: -o-transform 0.3s ease-out;
  transition: transform 0.3s ease-out;
}
.modal.in .modal-dialog {
  -webkit-transform: translate(0, 0);
  -ms-transform: translate(0, 0);
  -o-transform: translate(0, 0);
  transform: translate(0, 0);
}
.modal-open .modal {
  overflow-x: hidden;
  overflow-y: auto;
}
.modal-dialog {
  position: relative;
  width: auto;
  margin: 10px;
}
.modal-content {
  position: relative;
  background-color: #fff;
  border: 1px solid #999;
  border: 1px solid rgba(0, 0, 0, 0.2);
  border-radius: 3px;
  -webkit-box-shadow: 0 3px 9px rgba(0, 0, 0, 0.5);
  box-shadow: 0 3px 9px rgba(0, 0, 0, 0.5);
  background-clip: padding-box;
  outline: 0;
}
.modal-backdrop {
  position: fixed;
  top: 0;
  right: 0;
  bottom: 0;
  left: 0;
  z-index: 1040;
  background-color: #000;
}
.modal-backdrop.fade {
  opacity: 0;
  filter: alpha(opacity=0);
}
.modal-backdrop.in {
  opacity: 0.5;
  filter: alpha(opacity=50);
}
.modal-header {
  padding: 15px;
  border-bottom: 1px solid #e5e5e5;
}
.modal-header .close {
  margin-top: -2px;
}
.modal-title {
  margin: 0;
  line-height: 1.42857143;
}
.modal-body {
  position: relative;
  padding: 15px;
}
.modal-footer {
  padding: 15px;
  text-align: right;
  border-top: 1px solid #e5e5e5;
}
.modal-footer .btn + .btn {
  margin-left: 5px;
  margin-bottom: 0;
}
.modal-footer .btn-group .btn + .btn {
  margin-left: -1px;
}
.modal-footer .btn-block + .btn-block {
  margin-left: 0;
}
.modal-scrollbar-measure {
  position: absolute;
  top: -9999px;
  width: 50px;
  height: 50px;
  overflow: scroll;
}
@media (min-width: 768px) {
  .modal-dialog {
    width: 600px;
    margin: 30px auto;
  }
  .modal-content {
    -webkit-box-shadow: 0 5px 15px rgba(0, 0, 0, 0.5);
    box-shadow: 0 5px 15px rgba(0, 0, 0, 0.5);
  }
  .modal-sm {
    width: 300px;
  }
}
@media (min-width: 992px) {
  .modal-lg {
    width: 900px;
  }
}
.tooltip {
  position: absolute;
  z-index: 1070;
  display: block;
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
  font-style: normal;
  font-weight: normal;
  letter-spacing: normal;
  line-break: auto;
  line-height: 1.42857143;
  text-align: left;
  text-align: start;
  text-decoration: none;
  text-shadow: none;
  text-transform: none;
  white-space: normal;
  word-break: normal;
  word-spacing: normal;
  word-wrap: normal;
  font-size: 12px;
  opacity: 0;
  filter: alpha(opacity=0);
}
.tooltip.in {
  opacity: 0.9;
  filter: alpha(opacity=90);
}
.tooltip.top {
  margin-top: -3px;
  padding: 5px 0;
}
.tooltip.right {
  margin-left: 3px;
  padding: 0 5px;
}
.tooltip.bottom {
  margin-top: 3px;
  padding: 5px 0;
}
.tooltip.left {
  margin-left: -3px;
  padding: 0 5px;
}
.tooltip-inner {
  max-width: 200px;
  padding: 3px 8px;
  color: #fff;
  text-align: center;
  background-color: #000;
  border-radius: 2px;
}
.tooltip-arrow {
  position: absolute;
  width: 0;
  height: 0;
  border-color: transparent;
  border-style: solid;
}
.tooltip.top .tooltip-arrow {
  bottom: 0;
  left: 50%;
  margin-left: -5px;
  border-width: 5px 5px 0;
  border-top-color: #000;
}
.tooltip.top-left .tooltip-arrow {
  bottom: 0;
  right: 5px;
  margin-bottom: -5px;
  border-width: 5px 5px 0;
  border-top-color: #000;
}
.tooltip.top-right .tooltip-arrow {
  bottom: 0;
  left: 5px;
  margin-bottom: -5px;
  border-width: 5px 5px 0;
  border-top-color: #000;
}
.tooltip.right .tooltip-arrow {
  top: 50%;
  left: 0;
  margin-top: -5px;
  border-width: 5px 5px 5px 0;
  border-right-color: #000;
}
.tooltip.left .tooltip-arrow {
  top: 50%;
  right: 0;
  margin-top: -5px;
  border-width: 5px 0 5px 5px;
  border-left-color: #000;
}
.tooltip.bottom .tooltip-arrow {
  top: 0;
  left: 50%;
  margin-left: -5px;
  border-width: 0 5px 5px;
  border-bottom-color: #000;
}
.tooltip.bottom-left .tooltip-arrow {
  top: 0;
  right: 5px;
  margin-top: -5px;
  border-width: 0 5px 5px;
  border-bottom-color: #000;
}
.tooltip.bottom-right .tooltip-arrow {
  top: 0;
  left: 5px;
  margin-top: -5px;
  border-width: 0 5px 5px;
  border-bottom-color: #000;
}
.popover {
  position: absolute;
  top: 0;
  left: 0;
  z-index: 1060;
  display: none;
  max-width: 276px;
  padding: 1px;
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
  font-style: normal;
  font-weight: normal;
  letter-spacing: normal;
  line-break: auto;
  line-height: 1.42857143;
  text-align: left;
  text-align: start;
  text-decoration: none;
  text-shadow: none;
  text-transform: none;
  white-space: normal;
  word-break: normal;
  word-spacing: normal;
  word-wrap: normal;
  font-size: 13px;
  background-color: #fff;
  background-clip: padding-box;
  border: 1px solid #ccc;
  border: 1px solid rgba(0, 0, 0, 0.2);
  border-radius: 3px;
  -webkit-box-shadow: 0 5px 10px rgba(0, 0, 0, 0.2);
  box-shadow: 0 5px 10px rgba(0, 0, 0, 0.2);
}
.popover.top {
  margin-top: -10px;
}
.popover.right {
  margin-left: 10px;
}
.popover.bottom {
  margin-top: 10px;
}
.popover.left {
  margin-left: -10px;
}
.popover-title {
  margin: 0;
  padding: 8px 14px;
  font-size: 13px;
  background-color: #f7f7f7;
  border-bottom: 1px solid #ebebeb;
  border-radius: 2px 2px 0 0;
}
.popover-content {
  padding: 9px 14px;
}
.popover > .arrow,
.popover > .arrow:after {
  position: absolute;
  display: block;
  width: 0;
  height: 0;
  border-color: transparent;
  border-style: solid;
}
.popover > .arrow {
  border-width: 11px;
}
.popover > .arrow:after {
  border-width: 10px;
  content: "";
}
.popover.top > .arrow {
  left: 50%;
  margin-left: -11px;
  border-bottom-width: 0;
  border-top-color: #999999;
  border-top-color: rgba(0, 0, 0, 0.25);
  bottom: -11px;
}
.popover.top > .arrow:after {
  content: " ";
  bottom: 1px;
  margin-left: -10px;
  border-bottom-width: 0;
  border-top-color: #fff;
}
.popover.right > .arrow {
  top: 50%;
  left: -11px;
  margin-top: -11px;
  border-left-width: 0;
  border-right-color: #999999;
  border-right-color: rgba(0, 0, 0, 0.25);
}
.popover.right > .arrow:after {
  content: " ";
  left: 1px;
  bottom: -10px;
  border-left-width: 0;
  border-right-color: #fff;
}
.popover.bottom > .arrow {
  left: 50%;
  margin-left: -11px;
  border-top-width: 0;
  border-bottom-color: #999999;
  border-bottom-color: rgba(0, 0, 0, 0.25);
  top: -11px;
}
.popover.bottom > .arrow:after {
  content: " ";
  top: 1px;
  margin-left: -10px;
  border-top-width: 0;
  border-bottom-color: #fff;
}
.popover.left > .arrow {
  top: 50%;
  right: -11px;
  margin-top: -11px;
  border-right-width: 0;
  border-left-color: #999999;
  border-left-color: rgba(0, 0, 0, 0.25);
}
.popover.left > .arrow:after {
  content: " ";
  right: 1px;
  border-right-width: 0;
  border-left-color: #fff;
  bottom: -10px;
}
.carousel {
  position: relative;
}
.carousel-inner {
  position: relative;
  overflow: hidden;
  width: 100%;
}
.carousel-inner > .item {
  display: none;
  position: relative;
  -webkit-transition: 0.6s ease-in-out left;
  -o-transition: 0.6s ease-in-out left;
  transition: 0.6s ease-in-out left;
}
.carousel-inner > .item > img,
.carousel-inner > .item > a > img {
  line-height: 1;
}
@media all and (transform-3d), (-webkit-transform-3d) {
  .carousel-inner > .item {
    -webkit-transition: -webkit-transform 0.6s ease-in-out;
    -moz-transition: -moz-transform 0.6s ease-in-out;
    -o-transition: -o-transform 0.6s ease-in-out;
    transition: transform 0.6s ease-in-out;
    -webkit-backface-visibility: hidden;
    -moz-backface-visibility: hidden;
    backface-visibility: hidden;
    -webkit-perspective: 1000px;
    -moz-perspective: 1000px;
    perspective: 1000px;
  }
  .carousel-inner > .item.next,
  .carousel-inner > .item.active.right {
    -webkit-transform: translate3d(100%, 0, 0);
    transform: translate3d(100%, 0, 0);
    left: 0;
  }
  .carousel-inner > .item.prev,
  .carousel-inner > .item.active.left {
    -webkit-transform: translate3d(-100%, 0, 0);
    transform: translate3d(-100%, 0, 0);
    left: 0;
  }
  .carousel-inner > .item.next.left,
  .carousel-inner > .item.prev.right,
  .carousel-inner > .item.active {
    -webkit-transform: translate3d(0, 0, 0);
    transform: translate3d(0, 0, 0);
    left: 0;
  }
}
.carousel-inner > .active,
.carousel-inner > .next,
.carousel-inner > .prev {
  display: block;
}
.carousel-inner > .active {
  left: 0;
}
.carousel-inner > .next,
.carousel-inner > .prev {
  position: absolute;
  top: 0;
  width: 100%;
}
.carousel-inner > .next {
  left: 100%;
}
.carousel-inner > .prev {
  left: -100%;
}
.carousel-inner > .next.left,
.carousel-inner > .prev.right {
  left: 0;
}
.carousel-inner > .active.left {
  left: -100%;
}
.carousel-inner > .active.right {
  left: 100%;
}
.carousel-control {
  position: absolute;
  top: 0;
  left: 0;
  bottom: 0;
  width: 15%;
  opacity: 0.5;
  filter: alpha(opacity=50);
  font-size: 20px;
  color: #fff;
  text-align: center;
  text-shadow: 0 1px 2px rgba(0, 0, 0, 0.6);
  background-color: rgba(0, 0, 0, 0);
}
.carousel-control.left {
  background-image: -webkit-linear-gradient(left, rgba(0, 0, 0, 0.5) 0%, rgba(0, 0, 0, 0.0001) 100%);
  background-image: -o-linear-gradient(left, rgba(0, 0, 0, 0.5) 0%, rgba(0, 0, 0, 0.0001) 100%);
  background-image: linear-gradient(to right, rgba(0, 0, 0, 0.5) 0%, rgba(0, 0, 0, 0.0001) 100%);
  background-repeat: repeat-x;
  filter: progid:DXImageTransform.Microsoft.gradient(startColorstr='#80000000', endColorstr='#00000000', GradientType=1);
}
.carousel-control.right {
  left: auto;
  right: 0;
  background-image: -webkit-linear-gradient(left, rgba(0, 0, 0, 0.0001) 0%, rgba(0, 0, 0, 0.5) 100%);
  background-image: -o-linear-gradient(left, rgba(0, 0, 0, 0.0001) 0%, rgba(0, 0, 0, 0.5) 100%);
  background-image: linear-gradient(to right, rgba(0, 0, 0, 0.0001) 0%, rgba(0, 0, 0, 0.5) 100%);
  background-repeat: repeat-x;
  filter: progid:DXImageTransform.Microsoft.gradient(startColorstr='#00000000', endColorstr='#80000000', GradientType=1);
}
.carousel-control:hover,
.carousel-control:focus {
  outline: 0;
  color: #fff;
  text-decoration: none;
  opacity: 0.9;
  filter: alpha(opacity=90);
}
.carousel-control .icon-prev,
.carousel-control .icon-next,
.carousel-control .glyphicon-chevron-left,
.carousel-control .glyphicon-chevron-right {
  position: absolute;
  top: 50%;
  margin-top: -10px;
  z-index: 5;
  display: inline-block;
}
.carousel-control .icon-prev,
.carousel-control .glyphicon-chevron-left {
  left: 50%;
  margin-left: -10px;
}
.carousel-control .icon-next,
.carousel-control .glyphicon-chevron-right {
  right: 50%;
  margin-right: -10px;
}
.carousel-control .icon-prev,
.carousel-control .icon-next {
  width: 20px;
  height: 20px;
  line-height: 1;
  font-family: serif;
}
.carousel-control .icon-prev:before {
  content: '\2039';
}
.carousel-control .icon-next:before {
  content: '\203a';
}
.carousel-indicators {
  position: absolute;
  bottom: 10px;
  left: 50%;
  z-index: 15;
  width: 60%;
  margin-left: -30%;
  padding-left: 0;
  list-style: none;
  text-align: center;
}
.carousel-indicators li {
  display: inline-block;
  width: 10px;
  height: 10px;
  margin: 1px;
  text-indent: -999px;
  border: 1px solid #fff;
  border-radius: 10px;
  cursor: pointer;
  background-color: #000 \9;
  background-color: rgba(0, 0, 0, 0);
}
.carousel-indicators .active {
  margin: 0;
  width: 12px;
  height: 12px;
  background-color: #fff;
}
.carousel-caption {
  position: absolute;
  left: 15%;
  right: 15%;
  bottom: 20px;
  z-index: 10;
  padding-top: 20px;
  padding-bottom: 20px;
  color: #fff;
  text-align: center;
  text-shadow: 0 1px 2px rgba(0, 0, 0, 0.6);
}
.carousel-caption .btn {
  text-shadow: none;
}
@media screen and (min-width: 768px) {
  .carousel-control .glyphicon-chevron-left,
  .carousel-control .glyphicon-chevron-right,
  .carousel-control .icon-prev,
  .carousel-control .icon-next {
    width: 30px;
    height: 30px;
    margin-top: -10px;
    font-size: 30px;
  }
  .carousel-control .glyphicon-chevron-left,
  .carousel-control .icon-prev {
    margin-left: -10px;
  }
  .carousel-control .glyphicon-chevron-right,
  .carousel-control .icon-next {
    margin-right: -10px;
  }
  .carousel-caption {
    left: 20%;
    right: 20%;
    padding-bottom: 30px;
  }
  .carousel-indicators {
    bottom: 20px;
  }
}
.clearfix:before,
.clearfix:after,
.dl-horizontal dd:before,
.dl-horizontal dd:after,
.container:before,
.container:after,
.container-fluid:before,
.container-fluid:after,
.row:before,
.row:after,
.form-horizontal .form-group:before,
.form-horizontal .form-group:after,
.btn-toolbar:before,
.btn-toolbar:after,
.btn-group-vertical > .btn-group:before,
.btn-group-vertical > .btn-group:after,
.nav:before,
.nav:after,
.navbar:before,
.navbar:after,
.navbar-header:before,
.navbar-header:after,
.navbar-collapse:before,
.navbar-collapse:after,
.pager:before,
.pager:after,
.panel-body:before,
.panel-body:after,
.modal-header:before,
.modal-header:after,
.modal-footer:before,
.modal-footer:after,
.item_buttons:before,
.item_buttons:after {
  content: " ";
  display: table;
}
.clearfix:after,
.dl-horizontal dd:after,
.container:after,
.container-fluid:after,
.row:after,
.form-horizontal .form-group:after,
.btn-toolbar:after,
.btn-group-vertical > .btn-group:after,
.nav:after,
.navbar:after,
.navbar-header:after,
.navbar-collapse:after,
.pager:after,
.panel-body:after,
.modal-header:after,
.modal-footer:after,
.item_buttons:after {
  clear: both;
}
.center-block {
  display: block;
  margin-left: auto;
  margin-right: auto;
}
.pull-right {
  float: right !important;
}
.pull-left {
  float: left !important;
}
.hide {
  display: none !important;
}
.show {
  display: block !important;
}
.invisible {
  visibility: hidden;
}
.text-hide {
  font: 0/0 a;
  color: transparent;
  text-shadow: none;
  background-color: transparent;
  border: 0;
}
.hidden {
  display: none !important;
}
.affix {
  position: fixed;
}
@-ms-viewport {
  width: device-width;
}
.visible-xs,
.visible-sm,
.visible-md,
.visible-lg {
  display: none !important;
}
.visible-xs-block,
.visible-xs-inline,
.visible-xs-inline-block,
.visible-sm-block,
.visible-sm-inline,
.visible-sm-inline-block,
.visible-md-block,
.visible-md-inline,
.visible-md-inline-block,
.visible-lg-block,
.visible-lg-inline,
.visible-lg-inline-block {
  display: none !important;
}
@media (max-width: 767px) {
  .visible-xs {
    display: block !important;
  }
  table.visible-xs {
    display: table !important;
  }
  tr.visible-xs {
    display: table-row !important;
  }
  th.visible-xs,
  td.visible-xs {
    display: table-cell !important;
  }
}
@media (max-width: 767px) {
  .visible-xs-block {
    display: block !important;
  }
}
@media (max-width: 767px) {
  .visible-xs-inline {
    display: inline !important;
  }
}
@media (max-width: 767px) {
  .visible-xs-inline-block {
    display: inline-block !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm {
    display: block !important;
  }
  table.visible-sm {
    display: table !important;
  }
  tr.visible-sm {
    display: table-row !important;
  }
  th.visible-sm,
  td.visible-sm {
    display: table-cell !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm-block {
    display: block !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm-inline {
    display: inline !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm-inline-block {
    display: inline-block !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md {
    display: block !important;
  }
  table.visible-md {
    display: table !important;
  }
  tr.visible-md {
    display: table-row !important;
  }
  th.visible-md,
  td.visible-md {
    display: table-cell !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md-block {
    display: block !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md-inline {
    display: inline !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md-inline-block {
    display: inline-block !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg {
    display: block !important;
  }
  table.visible-lg {
    display: table !important;
  }
  tr.visible-lg {
    display: table-row !important;
  }
  th.visible-lg,
  td.visible-lg {
    display: table-cell !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg-block {
    display: block !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg-inline {
    display: inline !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg-inline-block {
    display: inline-block !important;
  }
}
@media (max-width: 767px) {
  .hidden-xs {
    display: none !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .hidden-sm {
    display: none !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .hidden-md {
    display: none !important;
  }
}
@media (min-width: 1200px) {
  .hidden-lg {
    display: none !important;
  }
}
.visible-print {
  display: none !important;
}
@media print {
  .visible-print {
    display: block !important;
  }
  table.visible-print {
    display: table !important;
  }
  tr.visible-print {
    display: table-row !important;
  }
  th.visible-print,
  td.visible-print {
    display: table-cell !important;
  }
}
.visible-print-block {
  display: none !important;
}
@media print {
  .visible-print-block {
    display: block !important;
  }
}
.visible-print-inline {
  display: none !important;
}
@media print {
  .visible-print-inline {
    display: inline !important;
  }
}
.visible-print-inline-block {
  display: none !important;
}
@media print {
  .visible-print-inline-block {
    display: inline-block !important;
  }
}
@media print {
  .hidden-print {
    display: none !important;
  }
}
/*!
*
* Font Awesome
*
*/
/*!
 *  Font Awesome 4.2.0 by @davegandy - http://fontawesome.io - @fontawesome
 *  License - http://fontawesome.io/license (Font: SIL OFL 1.1, CSS: MIT License)
 */
/* FONT PATH
 * -------------------------- */
@font-face {
  font-family: 'FontAwesome';
  src: url('../components/font-awesome/fonts/fontawesome-webfont.eot?v=4.2.0');
  src: url('../components/font-awesome/fonts/fontawesome-webfont.eot?#iefix&v=4.2.0') format('embedded-opentype'), url('../components/font-awesome/fonts/fontawesome-webfont.woff?v=4.2.0') format('woff'), url('../components/font-awesome/fonts/fontawesome-webfont.ttf?v=4.2.0') format('truetype'), url('../components/font-awesome/fonts/fontawesome-webfont.svg?v=4.2.0#fontawesomeregular') format('svg');
  font-weight: normal;
  font-style: normal;
}
.fa {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}
/* makes the font 33% larger relative to the icon container */
.fa-lg {
  font-size: 1.33333333em;
  line-height: 0.75em;
  vertical-align: -15%;
}
.fa-2x {
  font-size: 2em;
}
.fa-3x {
  font-size: 3em;
}
.fa-4x {
  font-size: 4em;
}
.fa-5x {
  font-size: 5em;
}
.fa-fw {
  width: 1.28571429em;
  text-align: center;
}
.fa-ul {
  padding-left: 0;
  margin-left: 2.14285714em;
  list-style-type: none;
}
.fa-ul > li {
  position: relative;
}
.fa-li {
  position: absolute;
  left: -2.14285714em;
  width: 2.14285714em;
  top: 0.14285714em;
  text-align: center;
}
.fa-li.fa-lg {
  left: -1.85714286em;
}
.fa-border {
  padding: .2em .25em .15em;
  border: solid 0.08em #eee;
  border-radius: .1em;
}
.pull-right {
  float: right;
}
.pull-left {
  float: left;
}
.fa.pull-left {
  margin-right: .3em;
}
.fa.pull-right {
  margin-left: .3em;
}
.fa-spin {
  -webkit-animation: fa-spin 2s infinite linear;
  animation: fa-spin 2s infinite linear;
}
@-webkit-keyframes fa-spin {
  0% {
    -webkit-transform: rotate(0deg);
    transform: rotate(0deg);
  }
  100% {
    -webkit-transform: rotate(359deg);
    transform: rotate(359deg);
  }
}
@keyframes fa-spin {
  0% {
    -webkit-transform: rotate(0deg);
    transform: rotate(0deg);
  }
  100% {
    -webkit-transform: rotate(359deg);
    transform: rotate(359deg);
  }
}
.fa-rotate-90 {
  filter: progid:DXImageTransform.Microsoft.BasicImage(rotation=1);
  -webkit-transform: rotate(90deg);
  -ms-transform: rotate(90deg);
  transform: rotate(90deg);
}
.fa-rotate-180 {
  filter: progid:DXImageTransform.Microsoft.BasicImage(rotation=2);
  -webkit-transform: rotate(180deg);
  -ms-transform: rotate(180deg);
  transform: rotate(180deg);
}
.fa-rotate-270 {
  filter: progid:DXImageTransform.Microsoft.BasicImage(rotation=3);
  -webkit-transform: rotate(270deg);
  -ms-transform: rotate(270deg);
  transform: rotate(270deg);
}
.fa-flip-horizontal {
  filter: progid:DXImageTransform.Microsoft.BasicImage(rotation=0, mirror=1);
  -webkit-transform: scale(-1, 1);
  -ms-transform: scale(-1, 1);
  transform: scale(-1, 1);
}
.fa-flip-vertical {
  filter: progid:DXImageTransform.Microsoft.BasicImage(rotation=2, mirror=1);
  -webkit-transform: scale(1, -1);
  -ms-transform: scale(1, -1);
  transform: scale(1, -1);
}
:root .fa-rotate-90,
:root .fa-rotate-180,
:root .fa-rotate-270,
:root .fa-flip-horizontal,
:root .fa-flip-vertical {
  filter: none;
}
.fa-stack {
  position: relative;
  display: inline-block;
  width: 2em;
  height: 2em;
  line-height: 2em;
  vertical-align: middle;
}
.fa-stack-1x,
.fa-stack-2x {
  position: absolute;
  left: 0;
  width: 100%;
  text-align: center;
}
.fa-stack-1x {
  line-height: inherit;
}
.fa-stack-2x {
  font-size: 2em;
}
.fa-inverse {
  color: #fff;
}
/* Font Awesome uses the Unicode Private Use Area (PUA) to ensure screen
   readers do not read off random characters that represent icons */
.fa-glass:before {
  content: "\f000";
}
.fa-music:before {
  content: "\f001";
}
.fa-search:before {
  content: "\f002";
}
.fa-envelope-o:before {
  content: "\f003";
}
.fa-heart:before {
  content: "\f004";
}
.fa-star:before {
  content: "\f005";
}
.fa-star-o:before {
  content: "\f006";
}
.fa-user:before {
  content: "\f007";
}
.fa-film:before {
  content: "\f008";
}
.fa-th-large:before {
  content: "\f009";
}
.fa-th:before {
  content: "\f00a";
}
.fa-th-list:before {
  content: "\f00b";
}
.fa-check:before {
  content: "\f00c";
}
.fa-remove:before,
.fa-close:before,
.fa-times:before {
  content: "\f00d";
}
.fa-search-plus:before {
  content: "\f00e";
}
.fa-search-minus:before {
  content: "\f010";
}
.fa-power-off:before {
  content: "\f011";
}
.fa-signal:before {
  content: "\f012";
}
.fa-gear:before,
.fa-cog:before {
  content: "\f013";
}
.fa-trash-o:before {
  content: "\f014";
}
.fa-home:before {
  content: "\f015";
}
.fa-file-o:before {
  content: "\f016";
}
.fa-clock-o:before {
  content: "\f017";
}
.fa-road:before {
  content: "\f018";
}
.fa-download:before {
  content: "\f019";
}
.fa-arrow-circle-o-down:before {
  content: "\f01a";
}
.fa-arrow-circle-o-up:before {
  content: "\f01b";
}
.fa-inbox:before {
  content: "\f01c";
}
.fa-play-circle-o:before {
  content: "\f01d";
}
.fa-rotate-right:before,
.fa-repeat:before {
  content: "\f01e";
}
.fa-refresh:before {
  content: "\f021";
}
.fa-list-alt:before {
  content: "\f022";
}
.fa-lock:before {
  content: "\f023";
}
.fa-flag:before {
  content: "\f024";
}
.fa-headphones:before {
  content: "\f025";
}
.fa-volume-off:before {
  content: "\f026";
}
.fa-volume-down:before {
  content: "\f027";
}
.fa-volume-up:before {
  content: "\f028";
}
.fa-qrcode:before {
  content: "\f029";
}
.fa-barcode:before {
  content: "\f02a";
}
.fa-tag:before {
  content: "\f02b";
}
.fa-tags:before {
  content: "\f02c";
}
.fa-book:before {
  content: "\f02d";
}
.fa-bookmark:before {
  content: "\f02e";
}
.fa-print:before {
  content: "\f02f";
}
.fa-camera:before {
  content: "\f030";
}
.fa-font:before {
  content: "\f031";
}
.fa-bold:before {
  content: "\f032";
}
.fa-italic:before {
  content: "\f033";
}
.fa-text-height:before {
  content: "\f034";
}
.fa-text-width:before {
  content: "\f035";
}
.fa-align-left:before {
  content: "\f036";
}
.fa-align-center:before {
  content: "\f037";
}
.fa-align-right:before {
  content: "\f038";
}
.fa-align-justify:before {
  content: "\f039";
}
.fa-list:before {
  content: "\f03a";
}
.fa-dedent:before,
.fa-outdent:before {
  content: "\f03b";
}
.fa-indent:before {
  content: "\f03c";
}
.fa-video-camera:before {
  content: "\f03d";
}
.fa-photo:before,
.fa-image:before,
.fa-picture-o:before {
  content: "\f03e";
}
.fa-pencil:before {
  content: "\f040";
}
.fa-map-marker:before {
  content: "\f041";
}
.fa-adjust:before {
  content: "\f042";
}
.fa-tint:before {
  content: "\f043";
}
.fa-edit:before,
.fa-pencil-square-o:before {
  content: "\f044";
}
.fa-share-square-o:before {
  content: "\f045";
}
.fa-check-square-o:before {
  content: "\f046";
}
.fa-arrows:before {
  content: "\f047";
}
.fa-step-backward:before {
  content: "\f048";
}
.fa-fast-backward:before {
  content: "\f049";
}
.fa-backward:before {
  content: "\f04a";
}
.fa-play:before {
  content: "\f04b";
}
.fa-pause:before {
  content: "\f04c";
}
.fa-stop:before {
  content: "\f04d";
}
.fa-forward:before {
  content: "\f04e";
}
.fa-fast-forward:before {
  content: "\f050";
}
.fa-step-forward:before {
  content: "\f051";
}
.fa-eject:before {
  content: "\f052";
}
.fa-chevron-left:before {
  content: "\f053";
}
.fa-chevron-right:before {
  content: "\f054";
}
.fa-plus-circle:before {
  content: "\f055";
}
.fa-minus-circle:before {
  content: "\f056";
}
.fa-times-circle:before {
  content: "\f057";
}
.fa-check-circle:before {
  content: "\f058";
}
.fa-question-circle:before {
  content: "\f059";
}
.fa-info-circle:before {
  content: "\f05a";
}
.fa-crosshairs:before {
  content: "\f05b";
}
.fa-times-circle-o:before {
  content: "\f05c";
}
.fa-check-circle-o:before {
  content: "\f05d";
}
.fa-ban:before {
  content: "\f05e";
}
.fa-arrow-left:before {
  content: "\f060";
}
.fa-arrow-right:before {
  content: "\f061";
}
.fa-arrow-up:before {
  content: "\f062";
}
.fa-arrow-down:before {
  content: "\f063";
}
.fa-mail-forward:before,
.fa-share:before {
  content: "\f064";
}
.fa-expand:before {
  content: "\f065";
}
.fa-compress:before {
  content: "\f066";
}
.fa-plus:before {
  content: "\f067";
}
.fa-minus:before {
  content: "\f068";
}
.fa-asterisk:before {
  content: "\f069";
}
.fa-exclamation-circle:before {
  content: "\f06a";
}
.fa-gift:before {
  content: "\f06b";
}
.fa-leaf:before {
  content: "\f06c";
}
.fa-fire:before {
  content: "\f06d";
}
.fa-eye:before {
  content: "\f06e";
}
.fa-eye-slash:before {
  content: "\f070";
}
.fa-warning:before,
.fa-exclamation-triangle:before {
  content: "\f071";
}
.fa-plane:before {
  content: "\f072";
}
.fa-calendar:before {
  content: "\f073";
}
.fa-random:before {
  content: "\f074";
}
.fa-comment:before {
  content: "\f075";
}
.fa-magnet:before {
  content: "\f076";
}
.fa-chevron-up:before {
  content: "\f077";
}
.fa-chevron-down:before {
  content: "\f078";
}
.fa-retweet:before {
  content: "\f079";
}
.fa-shopping-cart:before {
  content: "\f07a";
}
.fa-folder:before {
  content: "\f07b";
}
.fa-folder-open:before {
  content: "\f07c";
}
.fa-arrows-v:before {
  content: "\f07d";
}
.fa-arrows-h:before {
  content: "\f07e";
}
.fa-bar-chart-o:before,
.fa-bar-chart:before {
  content: "\f080";
}
.fa-twitter-square:before {
  content: "\f081";
}
.fa-facebook-square:before {
  content: "\f082";
}
.fa-camera-retro:before {
  content: "\f083";
}
.fa-key:before {
  content: "\f084";
}
.fa-gears:before,
.fa-cogs:before {
  content: "\f085";
}
.fa-comments:before {
  content: "\f086";
}
.fa-thumbs-o-up:before {
  content: "\f087";
}
.fa-thumbs-o-down:before {
  content: "\f088";
}
.fa-star-half:before {
  content: "\f089";
}
.fa-heart-o:before {
  content: "\f08a";
}
.fa-sign-out:before {
  content: "\f08b";
}
.fa-linkedin-square:before {
  content: "\f08c";
}
.fa-thumb-tack:before {
  content: "\f08d";
}
.fa-external-link:before {
  content: "\f08e";
}
.fa-sign-in:before {
  content: "\f090";
}
.fa-trophy:before {
  content: "\f091";
}
.fa-github-square:before {
  content: "\f092";
}
.fa-upload:before {
  content: "\f093";
}
.fa-lemon-o:before {
  content: "\f094";
}
.fa-phone:before {
  content: "\f095";
}
.fa-square-o:before {
  content: "\f096";
}
.fa-bookmark-o:before {
  content: "\f097";
}
.fa-phone-square:before {
  content: "\f098";
}
.fa-twitter:before {
  content: "\f099";
}
.fa-facebook:before {
  content: "\f09a";
}
.fa-github:before {
  content: "\f09b";
}
.fa-unlock:before {
  content: "\f09c";
}
.fa-credit-card:before {
  content: "\f09d";
}
.fa-rss:before {
  content: "\f09e";
}
.fa-hdd-o:before {
  content: "\f0a0";
}
.fa-bullhorn:before {
  content: "\f0a1";
}
.fa-bell:before {
  content: "\f0f3";
}
.fa-certificate:before {
  content: "\f0a3";
}
.fa-hand-o-right:before {
  content: "\f0a4";
}
.fa-hand-o-left:before {
  content: "\f0a5";
}
.fa-hand-o-up:before {
  content: "\f0a6";
}
.fa-hand-o-down:before {
  content: "\f0a7";
}
.fa-arrow-circle-left:before {
  content: "\f0a8";
}
.fa-arrow-circle-right:before {
  content: "\f0a9";
}
.fa-arrow-circle-up:before {
  content: "\f0aa";
}
.fa-arrow-circle-down:before {
  content: "\f0ab";
}
.fa-globe:before {
  content: "\f0ac";
}
.fa-wrench:before {
  content: "\f0ad";
}
.fa-tasks:before {
  content: "\f0ae";
}
.fa-filter:before {
  content: "\f0b0";
}
.fa-briefcase:before {
  content: "\f0b1";
}
.fa-arrows-alt:before {
  content: "\f0b2";
}
.fa-group:before,
.fa-users:before {
  content: "\f0c0";
}
.fa-chain:before,
.fa-link:before {
  content: "\f0c1";
}
.fa-cloud:before {
  content: "\f0c2";
}
.fa-flask:before {
  content: "\f0c3";
}
.fa-cut:before,
.fa-scissors:before {
  content: "\f0c4";
}
.fa-copy:before,
.fa-files-o:before {
  content: "\f0c5";
}
.fa-paperclip:before {
  content: "\f0c6";
}
.fa-save:before,
.fa-floppy-o:before {
  content: "\f0c7";
}
.fa-square:before {
  content: "\f0c8";
}
.fa-navicon:before,
.fa-reorder:before,
.fa-bars:before {
  content: "\f0c9";
}
.fa-list-ul:before {
  content: "\f0ca";
}
.fa-list-ol:before {
  content: "\f0cb";
}
.fa-strikethrough:before {
  content: "\f0cc";
}
.fa-underline:before {
  content: "\f0cd";
}
.fa-table:before {
  content: "\f0ce";
}
.fa-magic:before {
  content: "\f0d0";
}
.fa-truck:before {
  content: "\f0d1";
}
.fa-pinterest:before {
  content: "\f0d2";
}
.fa-pinterest-square:before {
  content: "\f0d3";
}
.fa-google-plus-square:before {
  content: "\f0d4";
}
.fa-google-plus:before {
  content: "\f0d5";
}
.fa-money:before {
  content: "\f0d6";
}
.fa-caret-down:before {
  content: "\f0d7";
}
.fa-caret-up:before {
  content: "\f0d8";
}
.fa-caret-left:before {
  content: "\f0d9";
}
.fa-caret-right:before {
  content: "\f0da";
}
.fa-columns:before {
  content: "\f0db";
}
.fa-unsorted:before,
.fa-sort:before {
  content: "\f0dc";
}
.fa-sort-down:before,
.fa-sort-desc:before {
  content: "\f0dd";
}
.fa-sort-up:before,
.fa-sort-asc:before {
  content: "\f0de";
}
.fa-envelope:before {
  content: "\f0e0";
}
.fa-linkedin:before {
  content: "\f0e1";
}
.fa-rotate-left:before,
.fa-undo:before {
  content: "\f0e2";
}
.fa-legal:before,
.fa-gavel:before {
  content: "\f0e3";
}
.fa-dashboard:before,
.fa-tachometer:before {
  content: "\f0e4";
}
.fa-comment-o:before {
  content: "\f0e5";
}
.fa-comments-o:before {
  content: "\f0e6";
}
.fa-flash:before,
.fa-bolt:before {
  content: "\f0e7";
}
.fa-sitemap:before {
  content: "\f0e8";
}
.fa-umbrella:before {
  content: "\f0e9";
}
.fa-paste:before,
.fa-clipboard:before {
  content: "\f0ea";
}
.fa-lightbulb-o:before {
  content: "\f0eb";
}
.fa-exchange:before {
  content: "\f0ec";
}
.fa-cloud-download:before {
  content: "\f0ed";
}
.fa-cloud-upload:before {
  content: "\f0ee";
}
.fa-user-md:before {
  content: "\f0f0";
}
.fa-stethoscope:before {
  content: "\f0f1";
}
.fa-suitcase:before {
  content: "\f0f2";
}
.fa-bell-o:before {
  content: "\f0a2";
}
.fa-coffee:before {
  content: "\f0f4";
}
.fa-cutlery:before {
  content: "\f0f5";
}
.fa-file-text-o:before {
  content: "\f0f6";
}
.fa-building-o:before {
  content: "\f0f7";
}
.fa-hospital-o:before {
  content: "\f0f8";
}
.fa-ambulance:before {
  content: "\f0f9";
}
.fa-medkit:before {
  content: "\f0fa";
}
.fa-fighter-jet:before {
  content: "\f0fb";
}
.fa-beer:before {
  content: "\f0fc";
}
.fa-h-square:before {
  content: "\f0fd";
}
.fa-plus-square:before {
  content: "\f0fe";
}
.fa-angle-double-left:before {
  content: "\f100";
}
.fa-angle-double-right:before {
  content: "\f101";
}
.fa-angle-double-up:before {
  content: "\f102";
}
.fa-angle-double-down:before {
  content: "\f103";
}
.fa-angle-left:before {
  content: "\f104";
}
.fa-angle-right:before {
  content: "\f105";
}
.fa-angle-up:before {
  content: "\f106";
}
.fa-angle-down:before {
  content: "\f107";
}
.fa-desktop:before {
  content: "\f108";
}
.fa-laptop:before {
  content: "\f109";
}
.fa-tablet:before {
  content: "\f10a";
}
.fa-mobile-phone:before,
.fa-mobile:before {
  content: "\f10b";
}
.fa-circle-o:before {
  content: "\f10c";
}
.fa-quote-left:before {
  content: "\f10d";
}
.fa-quote-right:before {
  content: "\f10e";
}
.fa-spinner:before {
  content: "\f110";
}
.fa-circle:before {
  content: "\f111";
}
.fa-mail-reply:before,
.fa-reply:before {
  content: "\f112";
}
.fa-github-alt:before {
  content: "\f113";
}
.fa-folder-o:before {
  content: "\f114";
}
.fa-folder-open-o:before {
  content: "\f115";
}
.fa-smile-o:before {
  content: "\f118";
}
.fa-frown-o:before {
  content: "\f119";
}
.fa-meh-o:before {
  content: "\f11a";
}
.fa-gamepad:before {
  content: "\f11b";
}
.fa-keyboard-o:before {
  content: "\f11c";
}
.fa-flag-o:before {
  content: "\f11d";
}
.fa-flag-checkered:before {
  content: "\f11e";
}
.fa-terminal:before {
  content: "\f120";
}
.fa-code:before {
  content: "\f121";
}
.fa-mail-reply-all:before,
.fa-reply-all:before {
  content: "\f122";
}
.fa-star-half-empty:before,
.fa-star-half-full:before,
.fa-star-half-o:before {
  content: "\f123";
}
.fa-location-arrow:before {
  content: "\f124";
}
.fa-crop:before {
  content: "\f125";
}
.fa-code-fork:before {
  content: "\f126";
}
.fa-unlink:before,
.fa-chain-broken:before {
  content: "\f127";
}
.fa-question:before {
  content: "\f128";
}
.fa-info:before {
  content: "\f129";
}
.fa-exclamation:before {
  content: "\f12a";
}
.fa-superscript:before {
  content: "\f12b";
}
.fa-subscript:before {
  content: "\f12c";
}
.fa-eraser:before {
  content: "\f12d";
}
.fa-puzzle-piece:before {
  content: "\f12e";
}
.fa-microphone:before {
  content: "\f130";
}
.fa-microphone-slash:before {
  content: "\f131";
}
.fa-shield:before {
  content: "\f132";
}
.fa-calendar-o:before {
  content: "\f133";
}
.fa-fire-extinguisher:before {
  content: "\f134";
}
.fa-rocket:before {
  content: "\f135";
}
.fa-maxcdn:before {
  content: "\f136";
}
.fa-chevron-circle-left:before {
  content: "\f137";
}
.fa-chevron-circle-right:before {
  content: "\f138";
}
.fa-chevron-circle-up:before {
  content: "\f139";
}
.fa-chevron-circle-down:before {
  content: "\f13a";
}
.fa-html5:before {
  content: "\f13b";
}
.fa-css3:before {
  content: "\f13c";
}
.fa-anchor:before {
  content: "\f13d";
}
.fa-unlock-alt:before {
  content: "\f13e";
}
.fa-bullseye:before {
  content: "\f140";
}
.fa-ellipsis-h:before {
  content: "\f141";
}
.fa-ellipsis-v:before {
  content: "\f142";
}
.fa-rss-square:before {
  content: "\f143";
}
.fa-play-circle:before {
  content: "\f144";
}
.fa-ticket:before {
  content: "\f145";
}
.fa-minus-square:before {
  content: "\f146";
}
.fa-minus-square-o:before {
  content: "\f147";
}
.fa-level-up:before {
  content: "\f148";
}
.fa-level-down:before {
  content: "\f149";
}
.fa-check-square:before {
  content: "\f14a";
}
.fa-pencil-square:before {
  content: "\f14b";
}
.fa-external-link-square:before {
  content: "\f14c";
}
.fa-share-square:before {
  content: "\f14d";
}
.fa-compass:before {
  content: "\f14e";
}
.fa-toggle-down:before,
.fa-caret-square-o-down:before {
  content: "\f150";
}
.fa-toggle-up:before,
.fa-caret-square-o-up:before {
  content: "\f151";
}
.fa-toggle-right:before,
.fa-caret-square-o-right:before {
  content: "\f152";
}
.fa-euro:before,
.fa-eur:before {
  content: "\f153";
}
.fa-gbp:before {
  content: "\f154";
}
.fa-dollar:before,
.fa-usd:before {
  content: "\f155";
}
.fa-rupee:before,
.fa-inr:before {
  content: "\f156";
}
.fa-cny:before,
.fa-rmb:before,
.fa-yen:before,
.fa-jpy:before {
  content: "\f157";
}
.fa-ruble:before,
.fa-rouble:before,
.fa-rub:before {
  content: "\f158";
}
.fa-won:before,
.fa-krw:before {
  content: "\f159";
}
.fa-bitcoin:before,
.fa-btc:before {
  content: "\f15a";
}
.fa-file:before {
  content: "\f15b";
}
.fa-file-text:before {
  content: "\f15c";
}
.fa-sort-alpha-asc:before {
  content: "\f15d";
}
.fa-sort-alpha-desc:before {
  content: "\f15e";
}
.fa-sort-amount-asc:before {
  content: "\f160";
}
.fa-sort-amount-desc:before {
  content: "\f161";
}
.fa-sort-numeric-asc:before {
  content: "\f162";
}
.fa-sort-numeric-desc:before {
  content: "\f163";
}
.fa-thumbs-up:before {
  content: "\f164";
}
.fa-thumbs-down:before {
  content: "\f165";
}
.fa-youtube-square:before {
  content: "\f166";
}
.fa-youtube:before {
  content: "\f167";
}
.fa-xing:before {
  content: "\f168";
}
.fa-xing-square:before {
  content: "\f169";
}
.fa-youtube-play:before {
  content: "\f16a";
}
.fa-dropbox:before {
  content: "\f16b";
}
.fa-stack-overflow:before {
  content: "\f16c";
}
.fa-instagram:before {
  content: "\f16d";
}
.fa-flickr:before {
  content: "\f16e";
}
.fa-adn:before {
  content: "\f170";
}
.fa-bitbucket:before {
  content: "\f171";
}
.fa-bitbucket-square:before {
  content: "\f172";
}
.fa-tumblr:before {
  content: "\f173";
}
.fa-tumblr-square:before {
  content: "\f174";
}
.fa-long-arrow-down:before {
  content: "\f175";
}
.fa-long-arrow-up:before {
  content: "\f176";
}
.fa-long-arrow-left:before {
  content: "\f177";
}
.fa-long-arrow-right:before {
  content: "\f178";
}
.fa-apple:before {
  content: "\f179";
}
.fa-windows:before {
  content: "\f17a";
}
.fa-android:before {
  content: "\f17b";
}
.fa-linux:before {
  content: "\f17c";
}
.fa-dribbble:before {
  content: "\f17d";
}
.fa-skype:before {
  content: "\f17e";
}
.fa-foursquare:before {
  content: "\f180";
}
.fa-trello:before {
  content: "\f181";
}
.fa-female:before {
  content: "\f182";
}
.fa-male:before {
  content: "\f183";
}
.fa-gittip:before {
  content: "\f184";
}
.fa-sun-o:before {
  content: "\f185";
}
.fa-moon-o:before {
  content: "\f186";
}
.fa-archive:before {
  content: "\f187";
}
.fa-bug:before {
  content: "\f188";
}
.fa-vk:before {
  content: "\f189";
}
.fa-weibo:before {
  content: "\f18a";
}
.fa-renren:before {
  content: "\f18b";
}
.fa-pagelines:before {
  content: "\f18c";
}
.fa-stack-exchange:before {
  content: "\f18d";
}
.fa-arrow-circle-o-right:before {
  content: "\f18e";
}
.fa-arrow-circle-o-left:before {
  content: "\f190";
}
.fa-toggle-left:before,
.fa-caret-square-o-left:before {
  content: "\f191";
}
.fa-dot-circle-o:before {
  content: "\f192";
}
.fa-wheelchair:before {
  content: "\f193";
}
.fa-vimeo-square:before {
  content: "\f194";
}
.fa-turkish-lira:before,
.fa-try:before {
  content: "\f195";
}
.fa-plus-square-o:before {
  content: "\f196";
}
.fa-space-shuttle:before {
  content: "\f197";
}
.fa-slack:before {
  content: "\f198";
}
.fa-envelope-square:before {
  content: "\f199";
}
.fa-wordpress:before {
  content: "\f19a";
}
.fa-openid:before {
  content: "\f19b";
}
.fa-institution:before,
.fa-bank:before,
.fa-university:before {
  content: "\f19c";
}
.fa-mortar-board:before,
.fa-graduation-cap:before {
  content: "\f19d";
}
.fa-yahoo:before {
  content: "\f19e";
}
.fa-google:before {
  content: "\f1a0";
}
.fa-reddit:before {
  content: "\f1a1";
}
.fa-reddit-square:before {
  content: "\f1a2";
}
.fa-stumbleupon-circle:before {
  content: "\f1a3";
}
.fa-stumbleupon:before {
  content: "\f1a4";
}
.fa-delicious:before {
  content: "\f1a5";
}
.fa-digg:before {
  content: "\f1a6";
}
.fa-pied-piper:before {
  content: "\f1a7";
}
.fa-pied-piper-alt:before {
  content: "\f1a8";
}
.fa-drupal:before {
  content: "\f1a9";
}
.fa-joomla:before {
  content: "\f1aa";
}
.fa-language:before {
  content: "\f1ab";
}
.fa-fax:before {
  content: "\f1ac";
}
.fa-building:before {
  content: "\f1ad";
}
.fa-child:before {
  content: "\f1ae";
}
.fa-paw:before {
  content: "\f1b0";
}
.fa-spoon:before {
  content: "\f1b1";
}
.fa-cube:before {
  content: "\f1b2";
}
.fa-cubes:before {
  content: "\f1b3";
}
.fa-behance:before {
  content: "\f1b4";
}
.fa-behance-square:before {
  content: "\f1b5";
}
.fa-steam:before {
  content: "\f1b6";
}
.fa-steam-square:before {
  content: "\f1b7";
}
.fa-recycle:before {
  content: "\f1b8";
}
.fa-automobile:before,
.fa-car:before {
  content: "\f1b9";
}
.fa-cab:before,
.fa-taxi:before {
  content: "\f1ba";
}
.fa-tree:before {
  content: "\f1bb";
}
.fa-spotify:before {
  content: "\f1bc";
}
.fa-deviantart:before {
  content: "\f1bd";
}
.fa-soundcloud:before {
  content: "\f1be";
}
.fa-database:before {
  content: "\f1c0";
}
.fa-file-pdf-o:before {
  content: "\f1c1";
}
.fa-file-word-o:before {
  content: "\f1c2";
}
.fa-file-excel-o:before {
  content: "\f1c3";
}
.fa-file-powerpoint-o:before {
  content: "\f1c4";
}
.fa-file-photo-o:before,
.fa-file-picture-o:before,
.fa-file-image-o:before {
  content: "\f1c5";
}
.fa-file-zip-o:before,
.fa-file-archive-o:before {
  content: "\f1c6";
}
.fa-file-sound-o:before,
.fa-file-audio-o:before {
  content: "\f1c7";
}
.fa-file-movie-o:before,
.fa-file-video-o:before {
  content: "\f1c8";
}
.fa-file-code-o:before {
  content: "\f1c9";
}
.fa-vine:before {
  content: "\f1ca";
}
.fa-codepen:before {
  content: "\f1cb";
}
.fa-jsfiddle:before {
  content: "\f1cc";
}
.fa-life-bouy:before,
.fa-life-buoy:before,
.fa-life-saver:before,
.fa-support:before,
.fa-life-ring:before {
  content: "\f1cd";
}
.fa-circle-o-notch:before {
  content: "\f1ce";
}
.fa-ra:before,
.fa-rebel:before {
  content: "\f1d0";
}
.fa-ge:before,
.fa-empire:before {
  content: "\f1d1";
}
.fa-git-square:before {
  content: "\f1d2";
}
.fa-git:before {
  content: "\f1d3";
}
.fa-hacker-news:before {
  content: "\f1d4";
}
.fa-tencent-weibo:before {
  content: "\f1d5";
}
.fa-qq:before {
  content: "\f1d6";
}
.fa-wechat:before,
.fa-weixin:before {
  content: "\f1d7";
}
.fa-send:before,
.fa-paper-plane:before {
  content: "\f1d8";
}
.fa-send-o:before,
.fa-paper-plane-o:before {
  content: "\f1d9";
}
.fa-history:before {
  content: "\f1da";
}
.fa-circle-thin:before {
  content: "\f1db";
}
.fa-header:before {
  content: "\f1dc";
}
.fa-paragraph:before {
  content: "\f1dd";
}
.fa-sliders:before {
  content: "\f1de";
}
.fa-share-alt:before {
  content: "\f1e0";
}
.fa-share-alt-square:before {
  content: "\f1e1";
}
.fa-bomb:before {
  content: "\f1e2";
}
.fa-soccer-ball-o:before,
.fa-futbol-o:before {
  content: "\f1e3";
}
.fa-tty:before {
  content: "\f1e4";
}
.fa-binoculars:before {
  content: "\f1e5";
}
.fa-plug:before {
  content: "\f1e6";
}
.fa-slideshare:before {
  content: "\f1e7";
}
.fa-twitch:before {
  content: "\f1e8";
}
.fa-yelp:before {
  content: "\f1e9";
}
.fa-newspaper-o:before {
  content: "\f1ea";
}
.fa-wifi:before {
  content: "\f1eb";
}
.fa-calculator:before {
  content: "\f1ec";
}
.fa-paypal:before {
  content: "\f1ed";
}
.fa-google-wallet:before {
  content: "\f1ee";
}
.fa-cc-visa:before {
  content: "\f1f0";
}
.fa-cc-mastercard:before {
  content: "\f1f1";
}
.fa-cc-discover:before {
  content: "\f1f2";
}
.fa-cc-amex:before {
  content: "\f1f3";
}
.fa-cc-paypal:before {
  content: "\f1f4";
}
.fa-cc-stripe:before {
  content: "\f1f5";
}
.fa-bell-slash:before {
  content: "\f1f6";
}
.fa-bell-slash-o:before {
  content: "\f1f7";
}
.fa-trash:before {
  content: "\f1f8";
}
.fa-copyright:before {
  content: "\f1f9";
}
.fa-at:before {
  content: "\f1fa";
}
.fa-eyedropper:before {
  content: "\f1fb";
}
.fa-paint-brush:before {
  content: "\f1fc";
}
.fa-birthday-cake:before {
  content: "\f1fd";
}
.fa-area-chart:before {
  content: "\f1fe";
}
.fa-pie-chart:before {
  content: "\f200";
}
.fa-line-chart:before {
  content: "\f201";
}
.fa-lastfm:before {
  content: "\f202";
}
.fa-lastfm-square:before {
  content: "\f203";
}
.fa-toggle-off:before {
  content: "\f204";
}
.fa-toggle-on:before {
  content: "\f205";
}
.fa-bicycle:before {
  content: "\f206";
}
.fa-bus:before {
  content: "\f207";
}
.fa-ioxhost:before {
  content: "\f208";
}
.fa-angellist:before {
  content: "\f209";
}
.fa-cc:before {
  content: "\f20a";
}
.fa-shekel:before,
.fa-sheqel:before,
.fa-ils:before {
  content: "\f20b";
}
.fa-meanpath:before {
  content: "\f20c";
}
/*!
*
* IPython base
*
*/
.modal.fade .modal-dialog {
  -webkit-transform: translate(0, 0);
  -ms-transform: translate(0, 0);
  -o-transform: translate(0, 0);
  transform: translate(0, 0);
}
code {
  color: #000;
}
pre {
  font-size: inherit;
  line-height: inherit;
}
label {
  font-weight: normal;
}
/* Make the page background atleast 100% the height of the view port */
/* Make the page itself atleast 70% the height of the view port */
.border-box-sizing {
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
.corner-all {
  border-radius: 2px;
}
.no-padding {
  padding: 0px;
}
/* Flexible box model classes */
/* Taken from Alex Russell http://infrequently.org/2009/08/css-3-progress/ */
/* This file is a compatability layer.  It allows the usage of flexible box 
model layouts accross multiple browsers, including older browsers.  The newest,
universal implementation of the flexible box model is used when available (see
`Modern browsers` comments below).  Browsers that are known to implement this 
new spec completely include:

    Firefox 28.0+
    Chrome 29.0+
    Internet Explorer 11+ 
    Opera 17.0+

Browsers not listed, including Safari, are supported via the styling under the
`Old browsers` comments below.
*/
.hbox {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
.hbox > * {
  /* Old browsers */
  -webkit-box-flex: 0;
  -moz-box-flex: 0;
  box-flex: 0;
  /* Modern browsers */
  flex: none;
}
.vbox {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
}
.vbox > * {
  /* Old browsers */
  -webkit-box-flex: 0;
  -moz-box-flex: 0;
  box-flex: 0;
  /* Modern browsers */
  flex: none;
}
.hbox.reverse,
.vbox.reverse,
.reverse {
  /* Old browsers */
  -webkit-box-direction: reverse;
  -moz-box-direction: reverse;
  box-direction: reverse;
  /* Modern browsers */
  flex-direction: row-reverse;
}
.hbox.box-flex0,
.vbox.box-flex0,
.box-flex0 {
  /* Old browsers */
  -webkit-box-flex: 0;
  -moz-box-flex: 0;
  box-flex: 0;
  /* Modern browsers */
  flex: none;
  width: auto;
}
.hbox.box-flex1,
.vbox.box-flex1,
.box-flex1 {
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
.hbox.box-flex,
.vbox.box-flex,
.box-flex {
  /* Old browsers */
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
.hbox.box-flex2,
.vbox.box-flex2,
.box-flex2 {
  /* Old browsers */
  -webkit-box-flex: 2;
  -moz-box-flex: 2;
  box-flex: 2;
  /* Modern browsers */
  flex: 2;
}
.box-group1 {
  /*  Deprecated */
  -webkit-box-flex-group: 1;
  -moz-box-flex-group: 1;
  box-flex-group: 1;
}
.box-group2 {
  /* Deprecated */
  -webkit-box-flex-group: 2;
  -moz-box-flex-group: 2;
  box-flex-group: 2;
}
.hbox.start,
.vbox.start,
.start {
  /* Old browsers */
  -webkit-box-pack: start;
  -moz-box-pack: start;
  box-pack: start;
  /* Modern browsers */
  justify-content: flex-start;
}
.hbox.end,
.vbox.end,
.end {
  /* Old browsers */
  -webkit-box-pack: end;
  -moz-box-pack: end;
  box-pack: end;
  /* Modern browsers */
  justify-content: flex-end;
}
.hbox.center,
.vbox.center,
.center {
  /* Old browsers */
  -webkit-box-pack: center;
  -moz-box-pack: center;
  box-pack: center;
  /* Modern browsers */
  justify-content: center;
}
.hbox.baseline,
.vbox.baseline,
.baseline {
  /* Old browsers */
  -webkit-box-pack: baseline;
  -moz-box-pack: baseline;
  box-pack: baseline;
  /* Modern browsers */
  justify-content: baseline;
}
.hbox.stretch,
.vbox.stretch,
.stretch {
  /* Old browsers */
  -webkit-box-pack: stretch;
  -moz-box-pack: stretch;
  box-pack: stretch;
  /* Modern browsers */
  justify-content: stretch;
}
.hbox.align-start,
.vbox.align-start,
.align-start {
  /* Old browsers */
  -webkit-box-align: start;
  -moz-box-align: start;
  box-align: start;
  /* Modern browsers */
  align-items: flex-start;
}
.hbox.align-end,
.vbox.align-end,
.align-end {
  /* Old browsers */
  -webkit-box-align: end;
  -moz-box-align: end;
  box-align: end;
  /* Modern browsers */
  align-items: flex-end;
}
.hbox.align-center,
.vbox.align-center,
.align-center {
  /* Old browsers */
  -webkit-box-align: center;
  -moz-box-align: center;
  box-align: center;
  /* Modern browsers */
  align-items: center;
}
.hbox.align-baseline,
.vbox.align-baseline,
.align-baseline {
  /* Old browsers */
  -webkit-box-align: baseline;
  -moz-box-align: baseline;
  box-align: baseline;
  /* Modern browsers */
  align-items: baseline;
}
.hbox.align-stretch,
.vbox.align-stretch,
.align-stretch {
  /* Old browsers */
  -webkit-box-align: stretch;
  -moz-box-align: stretch;
  box-align: stretch;
  /* Modern browsers */
  align-items: stretch;
}
div.error {
  margin: 2em;
  text-align: center;
}
div.error > h1 {
  font-size: 500%;
  line-height: normal;
}
div.error > p {
  font-size: 200%;
  line-height: normal;
}
div.traceback-wrapper {
  text-align: left;
  max-width: 800px;
  margin: auto;
}
/**
 * Primary styles
 *
 * Author: Jupyter Development Team
 */
body {
  background-color: #fff;
  /* This makes sure that the body covers the entire window and needs to
       be in a different element than the display: box in wrapper below */
  position: absolute;
  left: 0px;
  right: 0px;
  top: 0px;
  bottom: 0px;
  overflow: visible;
}
body > #header {
  /* Initially hidden to prevent FLOUC */
  display: none;
  background-color: #fff;
  /* Display over codemirror */
  position: relative;
  z-index: 100;
}
body > #header #header-container {
  padding-bottom: 5px;
  padding-top: 5px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
body > #header .header-bar {
  width: 100%;
  height: 1px;
  background: #e7e7e7;
  margin-bottom: -1px;
}
@media print {
  body > #header {
    display: none !important;
  }
}
#header-spacer {
  width: 100%;
  visibility: hidden;
}
@media print {
  #header-spacer {
    display: none;
  }
}
#ipython_notebook {
  padding-left: 0px;
  padding-top: 1px;
  padding-bottom: 1px;
}
@media (max-width: 991px) {
  #ipython_notebook {
    margin-left: 10px;
  }
}
[dir="rtl"] #ipython_notebook {
  float: right !important;
}
#noscript {
  width: auto;
  padding-top: 16px;
  padding-bottom: 16px;
  text-align: center;
  font-size: 22px;
  color: red;
  font-weight: bold;
}
#ipython_notebook img {
  height: 28px;
}
#site {
  width: 100%;
  display: none;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  overflow: auto;
}
@media print {
  #site {
    height: auto !important;
  }
}
/* Smaller buttons */
.ui-button .ui-button-text {
  padding: 0.2em 0.8em;
  font-size: 77%;
}
input.ui-button {
  padding: 0.3em 0.9em;
}
span#login_widget {
  float: right;
}
span#login_widget > .button,
#logout {
  color: #333;
  background-color: #fff;
  border-color: #ccc;
}
span#login_widget > .button:focus,
#logout:focus,
span#login_widget > .button.focus,
#logout.focus {
  color: #333;
  background-color: #e6e6e6;
  border-color: #8c8c8c;
}
span#login_widget > .button:hover,
#logout:hover {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
span#login_widget > .button:active,
#logout:active,
span#login_widget > .button.active,
#logout.active,
.open > .dropdown-togglespan#login_widget > .button,
.open > .dropdown-toggle#logout {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
span#login_widget > .button:active:hover,
#logout:active:hover,
span#login_widget > .button.active:hover,
#logout.active:hover,
.open > .dropdown-togglespan#login_widget > .button:hover,
.open > .dropdown-toggle#logout:hover,
span#login_widget > .button:active:focus,
#logout:active:focus,
span#login_widget > .button.active:focus,
#logout.active:focus,
.open > .dropdown-togglespan#login_widget > .button:focus,
.open > .dropdown-toggle#logout:focus,
span#login_widget > .button:active.focus,
#logout:active.focus,
span#login_widget > .button.active.focus,
#logout.active.focus,
.open > .dropdown-togglespan#login_widget > .button.focus,
.open > .dropdown-toggle#logout.focus {
  color: #333;
  background-color: #d4d4d4;
  border-color: #8c8c8c;
}
span#login_widget > .button:active,
#logout:active,
span#login_widget > .button.active,
#logout.active,
.open > .dropdown-togglespan#login_widget > .button,
.open > .dropdown-toggle#logout {
  background-image: none;
}
span#login_widget > .button.disabled:hover,
#logout.disabled:hover,
span#login_widget > .button[disabled]:hover,
#logout[disabled]:hover,
fieldset[disabled] span#login_widget > .button:hover,
fieldset[disabled] #logout:hover,
span#login_widget > .button.disabled:focus,
#logout.disabled:focus,
span#login_widget > .button[disabled]:focus,
#logout[disabled]:focus,
fieldset[disabled] span#login_widget > .button:focus,
fieldset[disabled] #logout:focus,
span#login_widget > .button.disabled.focus,
#logout.disabled.focus,
span#login_widget > .button[disabled].focus,
#logout[disabled].focus,
fieldset[disabled] span#login_widget > .button.focus,
fieldset[disabled] #logout.focus {
  background-color: #fff;
  border-color: #ccc;
}
span#login_widget > .button .badge,
#logout .badge {
  color: #fff;
  background-color: #333;
}
.nav-header {
  text-transform: none;
}
#header > span {
  margin-top: 10px;
}
.modal_stretch .modal-dialog {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  min-height: 80vh;
}
.modal_stretch .modal-dialog .modal-body {
  max-height: calc(100vh - 200px);
  overflow: auto;
  flex: 1;
}
@media (min-width: 768px) {
  .modal .modal-dialog {
    width: 700px;
  }
}
@media (min-width: 768px) {
  select.form-control {
    margin-left: 12px;
    margin-right: 12px;
  }
}
/*!
*
* IPython auth
*
*/
.center-nav {
  display: inline-block;
  margin-bottom: -4px;
}
/*!
*
* IPython tree view
*
*/
/* We need an invisible input field on top of the sentense*/
/* "Drag file onto the list ..." */
.alternate_upload {
  background-color: none;
  display: inline;
}
.alternate_upload.form {
  padding: 0;
  margin: 0;
}
.alternate_upload input.fileinput {
  text-align: center;
  vertical-align: middle;
  display: inline;
  opacity: 0;
  z-index: 2;
  width: 12ex;
  margin-right: -12ex;
}
.alternate_upload .btn-upload {
  height: 22px;
}
/**
 * Primary styles
 *
 * Author: Jupyter Development Team
 */
[dir="rtl"] #tabs li {
  float: right;
}
ul#tabs {
  margin-bottom: 4px;
}
[dir="rtl"] ul#tabs {
  margin-right: 0px;
}
ul#tabs a {
  padding-top: 6px;
  padding-bottom: 4px;
}
ul.breadcrumb a:focus,
ul.breadcrumb a:hover {
  text-decoration: none;
}
ul.breadcrumb i.icon-home {
  font-size: 16px;
  margin-right: 4px;
}
ul.breadcrumb span {
  color: #5e5e5e;
}
.list_toolbar {
  padding: 4px 0 4px 0;
  vertical-align: middle;
}
.list_toolbar .tree-buttons {
  padding-top: 1px;
}
[dir="rtl"] .list_toolbar .tree-buttons {
  float: left !important;
}
[dir="rtl"] .list_toolbar .pull-right {
  padding-top: 1px;
  float: left !important;
}
[dir="rtl"] .list_toolbar .pull-left {
  float: right !important;
}
.dynamic-buttons {
  padding-top: 3px;
  display: inline-block;
}
.list_toolbar [class*="span"] {
  min-height: 24px;
}
.list_header {
  font-weight: bold;
  background-color: #EEE;
}
.list_placeholder {
  font-weight: bold;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 7px;
  padding-right: 7px;
}
.list_container {
  margin-top: 4px;
  margin-bottom: 20px;
  border: 1px solid #ddd;
  border-radius: 2px;
}
.list_container > div {
  border-bottom: 1px solid #ddd;
}
.list_container > div:hover .list-item {
  background-color: red;
}
.list_container > div:last-child {
  border: none;
}
.list_item:hover .list_item {
  background-color: #ddd;
}
.list_item a {
  text-decoration: none;
}
.list_item:hover {
  background-color: #fafafa;
}
.list_header > div,
.list_item > div {
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 7px;
  padding-right: 7px;
  line-height: 22px;
}
.list_header > div input,
.list_item > div input {
  margin-right: 7px;
  margin-left: 14px;
  vertical-align: baseline;
  line-height: 22px;
  position: relative;
  top: -1px;
}
.list_header > div .item_link,
.list_item > div .item_link {
  margin-left: -1px;
  vertical-align: baseline;
  line-height: 22px;
}
.new-file input[type=checkbox] {
  visibility: hidden;
}
.item_name {
  line-height: 22px;
  height: 24px;
}
.item_icon {
  font-size: 14px;
  color: #5e5e5e;
  margin-right: 7px;
  margin-left: 7px;
  line-height: 22px;
  vertical-align: baseline;
}
.item_buttons {
  line-height: 1em;
  margin-left: -5px;
}
.item_buttons .btn,
.item_buttons .btn-group,
.item_buttons .input-group {
  float: left;
}
.item_buttons > .btn,
.item_buttons > .btn-group,
.item_buttons > .input-group {
  margin-left: 5px;
}
.item_buttons .btn {
  min-width: 13ex;
}
.item_buttons .running-indicator {
  padding-top: 4px;
  color: #5cb85c;
}
.item_buttons .kernel-name {
  padding-top: 4px;
  color: #5bc0de;
  margin-right: 7px;
  float: left;
}
.toolbar_info {
  height: 24px;
  line-height: 24px;
}
.list_item input:not([type=checkbox]) {
  padding-top: 3px;
  padding-bottom: 3px;
  height: 22px;
  line-height: 14px;
  margin: 0px;
}
.highlight_text {
  color: blue;
}
#project_name {
  display: inline-block;
  padding-left: 7px;
  margin-left: -2px;
}
#project_name > .breadcrumb {
  padding: 0px;
  margin-bottom: 0px;
  background-color: transparent;
  font-weight: bold;
}
#tree-selector {
  padding-right: 0px;
}
[dir="rtl"] #tree-selector a {
  float: right;
}
#button-select-all {
  min-width: 50px;
}
#select-all {
  margin-left: 7px;
  margin-right: 2px;
}
.menu_icon {
  margin-right: 2px;
}
.tab-content .row {
  margin-left: 0px;
  margin-right: 0px;
}
.folder_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f114";
}
.folder_icon:before.pull-left {
  margin-right: .3em;
}
.folder_icon:before.pull-right {
  margin-left: .3em;
}
.notebook_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f02d";
  position: relative;
  top: -1px;
}
.notebook_icon:before.pull-left {
  margin-right: .3em;
}
.notebook_icon:before.pull-right {
  margin-left: .3em;
}
.running_notebook_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f02d";
  position: relative;
  top: -1px;
  color: #5cb85c;
}
.running_notebook_icon:before.pull-left {
  margin-right: .3em;
}
.running_notebook_icon:before.pull-right {
  margin-left: .3em;
}
.file_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f016";
  position: relative;
  top: -2px;
}
.file_icon:before.pull-left {
  margin-right: .3em;
}
.file_icon:before.pull-right {
  margin-left: .3em;
}
#notebook_toolbar .pull-right {
  padding-top: 0px;
  margin-right: -1px;
}
ul#new-menu {
  left: auto;
  right: 0;
}
[dir="rtl"] #new-menu {
  text-align: right;
}
.kernel-menu-icon {
  padding-right: 12px;
  width: 24px;
  content: "\f096";
}
.kernel-menu-icon:before {
  content: "\f096";
}
.kernel-menu-icon-current:before {
  content: "\f00c";
}
#tab_content {
  padding-top: 20px;
}
#running .panel-group .panel {
  margin-top: 3px;
  margin-bottom: 1em;
}
#running .panel-group .panel .panel-heading {
  background-color: #EEE;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 7px;
  padding-right: 7px;
  line-height: 22px;
}
#running .panel-group .panel .panel-heading a:focus,
#running .panel-group .panel .panel-heading a:hover {
  text-decoration: none;
}
#running .panel-group .panel .panel-body {
  padding: 0px;
}
#running .panel-group .panel .panel-body .list_container {
  margin-top: 0px;
  margin-bottom: 0px;
  border: 0px;
  border-radius: 0px;
}
#running .panel-group .panel .panel-body .list_container .list_item {
  border-bottom: 1px solid #ddd;
}
#running .panel-group .panel .panel-body .list_container .list_item:last-child {
  border-bottom: 0px;
}
[dir="rtl"] #running .col-sm-8 {
  float: right !important;
}
.delete-button {
  display: none;
}
.duplicate-button {
  display: none;
}
.rename-button {
  display: none;
}
.shutdown-button {
  display: none;
}
.dynamic-instructions {
  display: inline-block;
  padding-top: 4px;
}
/*!
*
* IPython text editor webapp
*
*/
.selected-keymap i.fa {
  padding: 0px 5px;
}
.selected-keymap i.fa:before {
  content: "\f00c";
}
#mode-menu {
  overflow: auto;
  max-height: 20em;
}
.edit_app #header {
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
}
.edit_app #menubar .navbar {
  /* Use a negative 1 bottom margin, so the border overlaps the border of the
    header */
  margin-bottom: -1px;
}
.dirty-indicator {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  width: 20px;
}
.dirty-indicator.pull-left {
  margin-right: .3em;
}
.dirty-indicator.pull-right {
  margin-left: .3em;
}
.dirty-indicator-dirty {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  width: 20px;
}
.dirty-indicator-dirty.pull-left {
  margin-right: .3em;
}
.dirty-indicator-dirty.pull-right {
  margin-left: .3em;
}
.dirty-indicator-clean {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  width: 20px;
}
.dirty-indicator-clean.pull-left {
  margin-right: .3em;
}
.dirty-indicator-clean.pull-right {
  margin-left: .3em;
}
.dirty-indicator-clean:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f00c";
}
.dirty-indicator-clean:before.pull-left {
  margin-right: .3em;
}
.dirty-indicator-clean:before.pull-right {
  margin-left: .3em;
}
#filename {
  font-size: 16pt;
  display: table;
  padding: 0px 5px;
}
#current-mode {
  padding-left: 5px;
  padding-right: 5px;
}
#texteditor-backdrop {
  padding-top: 20px;
  padding-bottom: 20px;
}
@media not print {
  #texteditor-backdrop {
    background-color: #EEE;
  }
}
@media print {
  #texteditor-backdrop #texteditor-container .CodeMirror-gutter,
  #texteditor-backdrop #texteditor-container .CodeMirror-gutters {
    background-color: #fff;
  }
}
@media not print {
  #texteditor-backdrop #texteditor-container .CodeMirror-gutter,
  #texteditor-backdrop #texteditor-container .CodeMirror-gutters {
    background-color: #fff;
  }
}
@media not print {
  #texteditor-backdrop #texteditor-container {
    padding: 0px;
    background-color: #fff;
    -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
    box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  }
}
/*!
*
* IPython notebook
*
*/
/* CSS font colors for translated ANSI colors. */
.ansibold {
  font-weight: bold;
}
/* use dark versions for foreground, to improve visibility */
.ansiblack {
  color: black;
}
.ansired {
  color: darkred;
}
.ansigreen {
  color: darkgreen;
}
.ansiyellow {
  color: #c4a000;
}
.ansiblue {
  color: darkblue;
}
.ansipurple {
  color: darkviolet;
}
.ansicyan {
  color: steelblue;
}
.ansigray {
  color: gray;
}
/* and light for background, for the same reason */
.ansibgblack {
  background-color: black;
}
.ansibgred {
  background-color: red;
}
.ansibggreen {
  background-color: green;
}
.ansibgyellow {
  background-color: yellow;
}
.ansibgblue {
  background-color: blue;
}
.ansibgpurple {
  background-color: magenta;
}
.ansibgcyan {
  background-color: cyan;
}
.ansibggray {
  background-color: gray;
}
div.cell {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  border-radius: 2px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  border-width: 1px;
  border-style: solid;
  border-color: transparent;
  width: 100%;
  padding: 5px;
  /* This acts as a spacer between cells, that is outside the border */
  margin: 0px;
  outline: none;
  border-left-width: 1px;
  padding-left: 5px;
  background: linear-gradient(to right, transparent -40px, transparent 1px, transparent 1px, transparent 100%);
}
div.cell.jupyter-soft-selected {
  border-left-color: #90CAF9;
  border-left-color: #E3F2FD;
  border-left-width: 1px;
  padding-left: 5px;
  border-right-color: #E3F2FD;
  border-right-width: 1px;
  background: #E3F2FD;
}
@media print {
  div.cell.jupyter-soft-selected {
    border-color: transparent;
  }
}
div.cell.selected {
  border-color: #ababab;
  border-left-width: 0px;
  padding-left: 6px;
  background: linear-gradient(to right, #42A5F5 -40px, #42A5F5 5px, transparent 5px, transparent 100%);
}
@media print {
  div.cell.selected {
    border-color: transparent;
  }
}
div.cell.selected.jupyter-soft-selected {
  border-left-width: 0;
  padding-left: 6px;
  background: linear-gradient(to right, #42A5F5 -40px, #42A5F5 7px, #E3F2FD 7px, #E3F2FD 100%);
}
.edit_mode div.cell.selected {
  border-color: #66BB6A;
  border-left-width: 0px;
  padding-left: 6px;
  background: linear-gradient(to right, #66BB6A -40px, #66BB6A 5px, transparent 5px, transparent 100%);
}
@media print {
  .edit_mode div.cell.selected {
    border-color: transparent;
  }
}
.prompt {
  /* This needs to be wide enough for 3 digit prompt numbers: In[100]: */
  min-width: 14ex;
  /* This padding is tuned to match the padding on the CodeMirror editor. */
  padding: 0.4em;
  margin: 0px;
  font-family: monospace;
  text-align: right;
  /* This has to match that of the the CodeMirror class line-height below */
  line-height: 1.21429em;
  /* Don't highlight prompt number selection */
  -webkit-touch-callout: none;
  -webkit-user-select: none;
  -khtml-user-select: none;
  -moz-user-select: none;
  -ms-user-select: none;
  user-select: none;
  /* Use default cursor */
  cursor: default;
}
@media (max-width: 540px) {
  .prompt {
    text-align: left;
  }
}
div.inner_cell {
  min-width: 0;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
/* input_area and input_prompt must match in top border and margin for alignment */
div.input_area {
  border: 1px solid #cfcfcf;
  border-radius: 2px;
  background: #f7f7f7;
  line-height: 1.21429em;
}
/* This is needed so that empty prompt areas can collapse to zero height when there
   is no content in the output_subarea and the prompt. The main purpose of this is
   to make sure that empty JavaScript output_subareas have no height. */
div.prompt:empty {
  padding-top: 0;
  padding-bottom: 0;
}
div.unrecognized_cell {
  padding: 5px 5px 5px 0px;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
div.unrecognized_cell .inner_cell {
  border-radius: 2px;
  padding: 5px;
  font-weight: bold;
  color: red;
  border: 1px solid #cfcfcf;
  background: #eaeaea;
}
div.unrecognized_cell .inner_cell a {
  color: inherit;
  text-decoration: none;
}
div.unrecognized_cell .inner_cell a:hover {
  color: inherit;
  text-decoration: none;
}
@media (max-width: 540px) {
  div.unrecognized_cell > div.prompt {
    display: none;
  }
}
div.code_cell {
  /* avoid page breaking on code cells when printing */
}
@media print {
  div.code_cell {
    page-break-inside: avoid;
  }
}
/* any special styling for code cells that are currently running goes here */
div.input {
  page-break-inside: avoid;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
@media (max-width: 540px) {
  div.input {
    /* Old browsers */
    display: -webkit-box;
    -webkit-box-orient: vertical;
    -webkit-box-align: stretch;
    display: -moz-box;
    -moz-box-orient: vertical;
    -moz-box-align: stretch;
    display: box;
    box-orient: vertical;
    box-align: stretch;
    /* Modern browsers */
    display: flex;
    flex-direction: column;
    align-items: stretch;
  }
}
/* input_area and input_prompt must match in top border and margin for alignment */
div.input_prompt {
  color: #303F9F;
  border-top: 1px solid transparent;
}
div.input_area > div.highlight {
  margin: 0.4em;
  border: none;
  padding: 0px;
  background-color: transparent;
}
div.input_area > div.highlight > pre {
  margin: 0px;
  border: none;
  padding: 0px;
  background-color: transparent;
}
/* The following gets added to the <head> if it is detected that the user has a
 * monospace font with inconsistent normal/bold/italic height.  See
 * notebookmain.js.  Such fonts will have keywords vertically offset with
 * respect to the rest of the text.  The user should select a better font.
 * See: https://github.com/ipython/ipython/issues/1503
 *
 * .CodeMirror span {
 *      vertical-align: bottom;
 * }
 */
.CodeMirror {
  line-height: 1.21429em;
  /* Changed from 1em to our global default */
  font-size: 14px;
  height: auto;
  /* Changed to auto to autogrow */
  background: none;
  /* Changed from white to allow our bg to show through */
}
.CodeMirror-scroll {
  /*  The CodeMirror docs are a bit fuzzy on if overflow-y should be hidden or visible.*/
  /*  We have found that if it is visible, vertical scrollbars appear with font size changes.*/
  overflow-y: hidden;
  overflow-x: auto;
}
.CodeMirror-lines {
  /* In CM2, this used to be 0.4em, but in CM3 it went to 4px. We need the em value because */
  /* we have set a different line-height and want this to scale with that. */
  padding: 0.4em;
}
.CodeMirror-linenumber {
  padding: 0 8px 0 4px;
}
.CodeMirror-gutters {
  border-bottom-left-radius: 2px;
  border-top-left-radius: 2px;
}
.CodeMirror pre {
  /* In CM3 this went to 4px from 0 in CM2. We need the 0 value because of how we size */
  /* .CodeMirror-lines */
  padding: 0;
  border: 0;
  border-radius: 0;
}
/*

Original style from softwaremaniacs.org (c) Ivan Sagalaev <Maniac@SoftwareManiacs.Org>
Adapted from GitHub theme

*/
.highlight-base {
  color: #000;
}
.highlight-variable {
  color: #000;
}
.highlight-variable-2 {
  color: #1a1a1a;
}
.highlight-variable-3 {
  color: #333333;
}
.highlight-string {
  color: #BA2121;
}
.highlight-comment {
  color: #408080;
  font-style: italic;
}
.highlight-number {
  color: #080;
}
.highlight-atom {
  color: #88F;
}
.highlight-keyword {
  color: #008000;
  font-weight: bold;
}
.highlight-builtin {
  color: #008000;
}
.highlight-error {
  color: #f00;
}
.highlight-operator {
  color: #AA22FF;
  font-weight: bold;
}
.highlight-meta {
  color: #AA22FF;
}
/* previously not defined, copying from default codemirror */
.highlight-def {
  color: #00f;
}
.highlight-string-2 {
  color: #f50;
}
.highlight-qualifier {
  color: #555;
}
.highlight-bracket {
  color: #997;
}
.highlight-tag {
  color: #170;
}
.highlight-attribute {
  color: #00c;
}
.highlight-header {
  color: blue;
}
.highlight-quote {
  color: #090;
}
.highlight-link {
  color: #00c;
}
/* apply the same style to codemirror */
.cm-s-ipython span.cm-keyword {
  color: #008000;
  font-weight: bold;
}
.cm-s-ipython span.cm-atom {
  color: #88F;
}
.cm-s-ipython span.cm-number {
  color: #080;
}
.cm-s-ipython span.cm-def {
  color: #00f;
}
.cm-s-ipython span.cm-variable {
  color: #000;
}
.cm-s-ipython span.cm-operator {
  color: #AA22FF;
  font-weight: bold;
}
.cm-s-ipython span.cm-variable-2 {
  color: #1a1a1a;
}
.cm-s-ipython span.cm-variable-3 {
  color: #333333;
}
.cm-s-ipython span.cm-comment {
  color: #408080;
  font-style: italic;
}
.cm-s-ipython span.cm-string {
  color: #BA2121;
}
.cm-s-ipython span.cm-string-2 {
  color: #f50;
}
.cm-s-ipython span.cm-meta {
  color: #AA22FF;
}
.cm-s-ipython span.cm-qualifier {
  color: #555;
}
.cm-s-ipython span.cm-builtin {
  color: #008000;
}
.cm-s-ipython span.cm-bracket {
  color: #997;
}
.cm-s-ipython span.cm-tag {
  color: #170;
}
.cm-s-ipython span.cm-attribute {
  color: #00c;
}
.cm-s-ipython span.cm-header {
  color: blue;
}
.cm-s-ipython span.cm-quote {
  color: #090;
}
.cm-s-ipython span.cm-link {
  color: #00c;
}
.cm-s-ipython span.cm-error {
  color: #f00;
}
.cm-s-ipython span.cm-tab {
  background: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAADAAAAAMCAYAAAAkuj5RAAAAAXNSR0IArs4c6QAAAGFJREFUSMft1LsRQFAQheHPowAKoACx3IgEKtaEHujDjORSgWTH/ZOdnZOcM/sgk/kFFWY0qV8foQwS4MKBCS3qR6ixBJvElOobYAtivseIE120FaowJPN75GMu8j/LfMwNjh4HUpwg4LUAAAAASUVORK5CYII=);
  background-position: right;
  background-repeat: no-repeat;
}
div.output_wrapper {
  /* this position must be relative to enable descendents to be absolute within it */
  position: relative;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  z-index: 1;
}
/* class for the output area when it should be height-limited */
div.output_scroll {
  /* ideally, this would be max-height, but FF barfs all over that */
  height: 24em;
  /* FF needs this *and the wrapper* to specify full width, or it will shrinkwrap */
  width: 100%;
  overflow: auto;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 2px 8px rgba(0, 0, 0, 0.8);
  box-shadow: inset 0 2px 8px rgba(0, 0, 0, 0.8);
  display: block;
}
/* output div while it is collapsed */
div.output_collapsed {
  margin: 0px;
  padding: 0px;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
}
div.out_prompt_overlay {
  height: 100%;
  padding: 0px 0.4em;
  position: absolute;
  border-radius: 2px;
}
div.out_prompt_overlay:hover {
  /* use inner shadow to get border that is computed the same on WebKit/FF */
  -webkit-box-shadow: inset 0 0 1px #000;
  box-shadow: inset 0 0 1px #000;
  background: rgba(240, 240, 240, 0.5);
}
div.output_prompt {
  color: #D84315;
}
/* This class is the outer container of all output sections. */
div.output_area {
  padding: 0px;
  page-break-inside: avoid;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
div.output_area .MathJax_Display {
  text-align: left !important;
}
div.output_area .rendered_html table {
  margin-left: 0;
  margin-right: 0;
}
div.output_area .rendered_html img {
  margin-left: 0;
  margin-right: 0;
}
div.output_area img,
div.output_area svg {
  max-width: 100%;
  height: auto;
}
div.output_area img.unconfined,
div.output_area svg.unconfined {
  max-width: none;
}
/* This is needed to protect the pre formating from global settings such
   as that of bootstrap */
.output {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
}
@media (max-width: 540px) {
  div.output_area {
    /* Old browsers */
    display: -webkit-box;
    -webkit-box-orient: vertical;
    -webkit-box-align: stretch;
    display: -moz-box;
    -moz-box-orient: vertical;
    -moz-box-align: stretch;
    display: box;
    box-orient: vertical;
    box-align: stretch;
    /* Modern browsers */
    display: flex;
    flex-direction: column;
    align-items: stretch;
  }
}
div.output_area pre {
  margin: 0;
  padding: 0;
  border: 0;
  vertical-align: baseline;
  color: black;
  background-color: transparent;
  border-radius: 0;
}
/* This class is for the output subarea inside the output_area and after
   the prompt div. */
div.output_subarea {
  overflow-x: auto;
  padding: 0.4em;
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
  max-width: calc(100% - 14ex);
}
div.output_scroll div.output_subarea {
  overflow-x: visible;
}
/* The rest of the output_* classes are for special styling of the different
   output types */
/* all text output has this class: */
div.output_text {
  text-align: left;
  color: #000;
  /* This has to match that of the the CodeMirror class line-height below */
  line-height: 1.21429em;
}
/* stdout/stderr are 'text' as well as 'stream', but execute_result/error are *not* streams */
div.output_stderr {
  background: #fdd;
  /* very light red background for stderr */
}
div.output_latex {
  text-align: left;
}
/* Empty output_javascript divs should have no height */
div.output_javascript:empty {
  padding: 0;
}
.js-error {
  color: darkred;
}
/* raw_input styles */
div.raw_input_container {
  line-height: 1.21429em;
  padding-top: 5px;
}
pre.raw_input_prompt {
  /* nothing needed here. */
}
input.raw_input {
  font-family: monospace;
  font-size: inherit;
  color: inherit;
  width: auto;
  /* make sure input baseline aligns with prompt */
  vertical-align: baseline;
  /* padding + margin = 0.5em between prompt and cursor */
  padding: 0em 0.25em;
  margin: 0em 0.25em;
}
input.raw_input:focus {
  box-shadow: none;
}
p.p-space {
  margin-bottom: 10px;
}
div.output_unrecognized {
  padding: 5px;
  font-weight: bold;
  color: red;
}
div.output_unrecognized a {
  color: inherit;
  text-decoration: none;
}
div.output_unrecognized a:hover {
  color: inherit;
  text-decoration: none;
}
.rendered_html {
  color: #000;
  /* any extras will just be numbers: */
}
.rendered_html em {
  font-style: italic;
}
.rendered_html strong {
  font-weight: bold;
}
.rendered_html u {
  text-decoration: underline;
}
.rendered_html :link {
  text-decoration: underline;
}
.rendered_html :visited {
  text-decoration: underline;
}
.rendered_html h1 {
  font-size: 185.7%;
  margin: 1.08em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h2 {
  font-size: 157.1%;
  margin: 1.27em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h3 {
  font-size: 128.6%;
  margin: 1.55em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h4 {
  font-size: 100%;
  margin: 2em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h5 {
  font-size: 100%;
  margin: 2em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
  font-style: italic;
}
.rendered_html h6 {
  font-size: 100%;
  margin: 2em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
  font-style: italic;
}
.rendered_html h1:first-child {
  margin-top: 0.538em;
}
.rendered_html h2:first-child {
  margin-top: 0.636em;
}
.rendered_html h3:first-child {
  margin-top: 0.777em;
}
.rendered_html h4:first-child {
  margin-top: 1em;
}
.rendered_html h5:first-child {
  margin-top: 1em;
}
.rendered_html h6:first-child {
  margin-top: 1em;
}
.rendered_html ul {
  list-style: disc;
  margin: 0em 2em;
  padding-left: 0px;
}
.rendered_html ul ul {
  list-style: square;
  margin: 0em 2em;
}
.rendered_html ul ul ul {
  list-style: circle;
  margin: 0em 2em;
}
.rendered_html ol {
  list-style: decimal;
  margin: 0em 2em;
  padding-left: 0px;
}
.rendered_html ol ol {
  list-style: upper-alpha;
  margin: 0em 2em;
}
.rendered_html ol ol ol {
  list-style: lower-alpha;
  margin: 0em 2em;
}
.rendered_html ol ol ol ol {
  list-style: lower-roman;
  margin: 0em 2em;
}
.rendered_html ol ol ol ol ol {
  list-style: decimal;
  margin: 0em 2em;
}
.rendered_html * + ul {
  margin-top: 1em;
}
.rendered_html * + ol {
  margin-top: 1em;
}
.rendered_html hr {
  color: black;
  background-color: black;
}
.rendered_html pre {
  margin: 1em 2em;
}
.rendered_html pre,
.rendered_html code {
  border: 0;
  background-color: #fff;
  color: #000;
  font-size: 100%;
  padding: 0px;
}
.rendered_html blockquote {
  margin: 1em 2em;
}
.rendered_html table {
  margin-left: auto;
  margin-right: auto;
  border: 1px solid black;
  border-collapse: collapse;
}
.rendered_html tr,
.rendered_html th,
.rendered_html td {
  border: 1px solid black;
  border-collapse: collapse;
  margin: 1em 2em;
}
.rendered_html td,
.rendered_html th {
  text-align: left;
  vertical-align: middle;
  padding: 4px;
}
.rendered_html th {
  font-weight: bold;
}
.rendered_html * + table {
  margin-top: 1em;
}
.rendered_html p {
  text-align: left;
}
.rendered_html * + p {
  margin-top: 1em;
}
.rendered_html img {
  display: block;
  margin-left: auto;
  margin-right: auto;
}
.rendered_html * + img {
  margin-top: 1em;
}
.rendered_html img,
.rendered_html svg {
  max-width: 100%;
  height: auto;
}
.rendered_html img.unconfined,
.rendered_html svg.unconfined {
  max-width: none;
}
div.text_cell {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
@media (max-width: 540px) {
  div.text_cell > div.prompt {
    display: none;
  }
}
div.text_cell_render {
  /*font-family: "Helvetica Neue", Arial, Helvetica, Geneva, sans-serif;*/
  outline: none;
  resize: none;
  width: inherit;
  border-style: none;
  padding: 0.5em 0.5em 0.5em 0.4em;
  color: #000;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
a.anchor-link:link {
  text-decoration: none;
  padding: 0px 20px;
  visibility: hidden;
}
h1:hover .anchor-link,
h2:hover .anchor-link,
h3:hover .anchor-link,
h4:hover .anchor-link,
h5:hover .anchor-link,
h6:hover .anchor-link {
  visibility: visible;
}
.text_cell.rendered .input_area {
  display: none;
}
.text_cell.rendered .rendered_html {
  overflow-x: auto;
  overflow-y: hidden;
}
.text_cell.unrendered .text_cell_render {
  display: none;
}
.cm-header-1,
.cm-header-2,
.cm-header-3,
.cm-header-4,
.cm-header-5,
.cm-header-6 {
  font-weight: bold;
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
}
.cm-header-1 {
  font-size: 185.7%;
}
.cm-header-2 {
  font-size: 157.1%;
}
.cm-header-3 {
  font-size: 128.6%;
}
.cm-header-4 {
  font-size: 110%;
}
.cm-header-5 {
  font-size: 100%;
  font-style: italic;
}
.cm-header-6 {
  font-size: 100%;
  font-style: italic;
}
/*!
*
* IPython notebook webapp
*
*/
@media (max-width: 767px) {
  .notebook_app {
    padding-left: 0px;
    padding-right: 0px;
  }
}
#ipython-main-app {
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  height: 100%;
}
div#notebook_panel {
  margin: 0px;
  padding: 0px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  height: 100%;
}
div#notebook {
  font-size: 14px;
  line-height: 20px;
  overflow-y: hidden;
  overflow-x: auto;
  width: 100%;
  /* This spaces the page away from the edge of the notebook area */
  padding-top: 20px;
  margin: 0px;
  outline: none;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  min-height: 100%;
}
@media not print {
  #notebook-container {
    padding: 15px;
    background-color: #fff;
    min-height: 0;
    -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
    box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  }
}
@media print {
  #notebook-container {
    width: 100%;
  }
}
div.ui-widget-content {
  border: 1px solid #ababab;
  outline: none;
}
pre.dialog {
  background-color: #f7f7f7;
  border: 1px solid #ddd;
  border-radius: 2px;
  padding: 0.4em;
  padding-left: 2em;
}
p.dialog {
  padding: 0.2em;
}
/* Word-wrap output correctly.  This is the CSS3 spelling, though Firefox seems
   to not honor it correctly.  Webkit browsers (Chrome, rekonq, Safari) do.
 */
pre,
code,
kbd,
samp {
  white-space: pre-wrap;
}
#fonttest {
  font-family: monospace;
}
p {
  margin-bottom: 0;
}
.end_space {
  min-height: 100px;
  transition: height .2s ease;
}
.notebook_app > #header {
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
}
@media not print {
  .notebook_app {
    background-color: #EEE;
  }
}
kbd {
  border-style: solid;
  border-width: 1px;
  box-shadow: none;
  margin: 2px;
  padding-left: 2px;
  padding-right: 2px;
  padding-top: 1px;
  padding-bottom: 1px;
}
/* CSS for the cell toolbar */
.celltoolbar {
  border: thin solid #CFCFCF;
  border-bottom: none;
  background: #EEE;
  border-radius: 2px 2px 0px 0px;
  width: 100%;
  height: 29px;
  padding-right: 4px;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
  /* Old browsers */
  -webkit-box-pack: end;
  -moz-box-pack: end;
  box-pack: end;
  /* Modern browsers */
  justify-content: flex-end;
  display: -webkit-flex;
}
@media print {
  .celltoolbar {
    display: none;
  }
}
.ctb_hideshow {
  display: none;
  vertical-align: bottom;
}
/* ctb_show is added to the ctb_hideshow div to show the cell toolbar.
   Cell toolbars are only shown when the ctb_global_show class is also set.
*/
.ctb_global_show .ctb_show.ctb_hideshow {
  display: block;
}
.ctb_global_show .ctb_show + .input_area,
.ctb_global_show .ctb_show + div.text_cell_input,
.ctb_global_show .ctb_show ~ div.text_cell_render {
  border-top-right-radius: 0px;
  border-top-left-radius: 0px;
}
.ctb_global_show .ctb_show ~ div.text_cell_render {
  border: 1px solid #cfcfcf;
}
.celltoolbar {
  font-size: 87%;
  padding-top: 3px;
}
.celltoolbar select {
  display: block;
  width: 100%;
  height: 32px;
  padding: 6px 12px;
  font-size: 13px;
  line-height: 1.42857143;
  color: #555555;
  background-color: #fff;
  background-image: none;
  border: 1px solid #ccc;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  -webkit-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  -o-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
  width: inherit;
  font-size: inherit;
  height: 22px;
  padding: 0px;
  display: inline-block;
}
.celltoolbar select:focus {
  border-color: #66afe9;
  outline: 0;
  -webkit-box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
  box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
}
.celltoolbar select::-moz-placeholder {
  color: #999;
  opacity: 1;
}
.celltoolbar select:-ms-input-placeholder {
  color: #999;
}
.celltoolbar select::-webkit-input-placeholder {
  color: #999;
}
.celltoolbar select::-ms-expand {
  border: 0;
  background-color: transparent;
}
.celltoolbar select[disabled],
.celltoolbar select[readonly],
fieldset[disabled] .celltoolbar select {
  background-color: #eeeeee;
  opacity: 1;
}
.celltoolbar select[disabled],
fieldset[disabled] .celltoolbar select {
  cursor: not-allowed;
}
textarea.celltoolbar select {
  height: auto;
}
select.celltoolbar select {
  height: 30px;
  line-height: 30px;
}
textarea.celltoolbar select,
select[multiple].celltoolbar select {
  height: auto;
}
.celltoolbar label {
  margin-left: 5px;
  margin-right: 5px;
}
.completions {
  position: absolute;
  z-index: 110;
  overflow: hidden;
  border: 1px solid #ababab;
  border-radius: 2px;
  -webkit-box-shadow: 0px 6px 10px -1px #adadad;
  box-shadow: 0px 6px 10px -1px #adadad;
  line-height: 1;
}
.completions select {
  background: white;
  outline: none;
  border: none;
  padding: 0px;
  margin: 0px;
  overflow: auto;
  font-family: monospace;
  font-size: 110%;
  color: #000;
  width: auto;
}
.completions select option.context {
  color: #286090;
}
#kernel_logo_widget {
  float: right !important;
  float: right;
}
#kernel_logo_widget .current_kernel_logo {
  display: none;
  margin-top: -1px;
  margin-bottom: -1px;
  width: 32px;
  height: 32px;
}
#menubar {
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  margin-top: 1px;
}
#menubar .navbar {
  border-top: 1px;
  border-radius: 0px 0px 2px 2px;
  margin-bottom: 0px;
}
#menubar .navbar-toggle {
  float: left;
  padding-top: 7px;
  padding-bottom: 7px;
  border: none;
}
#menubar .navbar-collapse {
  clear: left;
}
.nav-wrapper {
  border-bottom: 1px solid #e7e7e7;
}
i.menu-icon {
  padding-top: 4px;
}
ul#help_menu li a {
  overflow: hidden;
  padding-right: 2.2em;
}
ul#help_menu li a i {
  margin-right: -1.2em;
}
.dropdown-submenu {
  position: relative;
}
.dropdown-submenu > .dropdown-menu {
  top: 0;
  left: 100%;
  margin-top: -6px;
  margin-left: -1px;
}
.dropdown-submenu:hover > .dropdown-menu {
  display: block;
}
.dropdown-submenu > a:after {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  display: block;
  content: "\f0da";
  float: right;
  color: #333333;
  margin-top: 2px;
  margin-right: -10px;
}
.dropdown-submenu > a:after.pull-left {
  margin-right: .3em;
}
.dropdown-submenu > a:after.pull-right {
  margin-left: .3em;
}
.dropdown-submenu:hover > a:after {
  color: #262626;
}
.dropdown-submenu.pull-left {
  float: none;
}
.dropdown-submenu.pull-left > .dropdown-menu {
  left: -100%;
  margin-left: 10px;
}
#notification_area {
  float: right !important;
  float: right;
  z-index: 10;
}
.indicator_area {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
}
#kernel_indicator {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
  border-left: 1px solid;
}
#kernel_indicator .kernel_indicator_name {
  padding-left: 5px;
  padding-right: 5px;
}
#modal_indicator {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
}
#readonly-indicator {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
  margin-top: 2px;
  margin-bottom: 0px;
  margin-left: 0px;
  margin-right: 0px;
  display: none;
}
.modal_indicator:before {
  width: 1.28571429em;
  text-align: center;
}
.edit_mode .modal_indicator:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f040";
}
.edit_mode .modal_indicator:before.pull-left {
  margin-right: .3em;
}
.edit_mode .modal_indicator:before.pull-right {
  margin-left: .3em;
}
.command_mode .modal_indicator:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: ' ';
}
.command_mode .modal_indicator:before.pull-left {
  margin-right: .3em;
}
.command_mode .modal_indicator:before.pull-right {
  margin-left: .3em;
}
.kernel_idle_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f10c";
}
.kernel_idle_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_idle_icon:before.pull-right {
  margin-left: .3em;
}
.kernel_busy_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f111";
}
.kernel_busy_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_busy_icon:before.pull-right {
  margin-left: .3em;
}
.kernel_dead_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f1e2";
}
.kernel_dead_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_dead_icon:before.pull-right {
  margin-left: .3em;
}
.kernel_disconnected_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f127";
}
.kernel_disconnected_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_disconnected_icon:before.pull-right {
  margin-left: .3em;
}
.notification_widget {
  color: #777;
  z-index: 10;
  background: rgba(240, 240, 240, 0.5);
  margin-right: 4px;
  color: #333;
  background-color: #fff;
  border-color: #ccc;
}
.notification_widget:focus,
.notification_widget.focus {
  color: #333;
  background-color: #e6e6e6;
  border-color: #8c8c8c;
}
.notification_widget:hover {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.notification_widget:active,
.notification_widget.active,
.open > .dropdown-toggle.notification_widget {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.notification_widget:active:hover,
.notification_widget.active:hover,
.open > .dropdown-toggle.notification_widget:hover,
.notification_widget:active:focus,
.notification_widget.active:focus,
.open > .dropdown-toggle.notification_widget:focus,
.notification_widget:active.focus,
.notification_widget.active.focus,
.open > .dropdown-toggle.notification_widget.focus {
  color: #333;
  background-color: #d4d4d4;
  border-color: #8c8c8c;
}
.notification_widget:active,
.notification_widget.active,
.open > .dropdown-toggle.notification_widget {
  background-image: none;
}
.notification_widget.disabled:hover,
.notification_widget[disabled]:hover,
fieldset[disabled] .notification_widget:hover,
.notification_widget.disabled:focus,
.notification_widget[disabled]:focus,
fieldset[disabled] .notification_widget:focus,
.notification_widget.disabled.focus,
.notification_widget[disabled].focus,
fieldset[disabled] .notification_widget.focus {
  background-color: #fff;
  border-color: #ccc;
}
.notification_widget .badge {
  color: #fff;
  background-color: #333;
}
.notification_widget.warning {
  color: #fff;
  background-color: #f0ad4e;
  border-color: #eea236;
}
.notification_widget.warning:focus,
.notification_widget.warning.focus {
  color: #fff;
  background-color: #ec971f;
  border-color: #985f0d;
}
.notification_widget.warning:hover {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.notification_widget.warning:active,
.notification_widget.warning.active,
.open > .dropdown-toggle.notification_widget.warning {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.notification_widget.warning:active:hover,
.notification_widget.warning.active:hover,
.open > .dropdown-toggle.notification_widget.warning:hover,
.notification_widget.warning:active:focus,
.notification_widget.warning.active:focus,
.open > .dropdown-toggle.notification_widget.warning:focus,
.notification_widget.warning:active.focus,
.notification_widget.warning.active.focus,
.open > .dropdown-toggle.notification_widget.warning.focus {
  color: #fff;
  background-color: #d58512;
  border-color: #985f0d;
}
.notification_widget.warning:active,
.notification_widget.warning.active,
.open > .dropdown-toggle.notification_widget.warning {
  background-image: none;
}
.notification_widget.warning.disabled:hover,
.notification_widget.warning[disabled]:hover,
fieldset[disabled] .notification_widget.warning:hover,
.notification_widget.warning.disabled:focus,
.notification_widget.warning[disabled]:focus,
fieldset[disabled] .notification_widget.warning:focus,
.notification_widget.warning.disabled.focus,
.notification_widget.warning[disabled].focus,
fieldset[disabled] .notification_widget.warning.focus {
  background-color: #f0ad4e;
  border-color: #eea236;
}
.notification_widget.warning .badge {
  color: #f0ad4e;
  background-color: #fff;
}
.notification_widget.success {
  color: #fff;
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.notification_widget.success:focus,
.notification_widget.success.focus {
  color: #fff;
  background-color: #449d44;
  border-color: #255625;
}
.notification_widget.success:hover {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.notification_widget.success:active,
.notification_widget.success.active,
.open > .dropdown-toggle.notification_widget.success {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.notification_widget.success:active:hover,
.notification_widget.success.active:hover,
.open > .dropdown-toggle.notification_widget.success:hover,
.notification_widget.success:active:focus,
.notification_widget.success.active:focus,
.open > .dropdown-toggle.notification_widget.success:focus,
.notification_widget.success:active.focus,
.notification_widget.success.active.focus,
.open > .dropdown-toggle.notification_widget.success.focus {
  color: #fff;
  background-color: #398439;
  border-color: #255625;
}
.notification_widget.success:active,
.notification_widget.success.active,
.open > .dropdown-toggle.notification_widget.success {
  background-image: none;
}
.notification_widget.success.disabled:hover,
.notification_widget.success[disabled]:hover,
fieldset[disabled] .notification_widget.success:hover,
.notification_widget.success.disabled:focus,
.notification_widget.success[disabled]:focus,
fieldset[disabled] .notification_widget.success:focus,
.notification_widget.success.disabled.focus,
.notification_widget.success[disabled].focus,
fieldset[disabled] .notification_widget.success.focus {
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.notification_widget.success .badge {
  color: #5cb85c;
  background-color: #fff;
}
.notification_widget.info {
  color: #fff;
  background-color: #5bc0de;
  border-color: #46b8da;
}
.notification_widget.info:focus,
.notification_widget.info.focus {
  color: #fff;
  background-color: #31b0d5;
  border-color: #1b6d85;
}
.notification_widget.info:hover {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.notification_widget.info:active,
.notification_widget.info.active,
.open > .dropdown-toggle.notification_widget.info {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.notification_widget.info:active:hover,
.notification_widget.info.active:hover,
.open > .dropdown-toggle.notification_widget.info:hover,
.notification_widget.info:active:focus,
.notification_widget.info.active:focus,
.open > .dropdown-toggle.notification_widget.info:focus,
.notification_widget.info:active.focus,
.notification_widget.info.active.focus,
.open > .dropdown-toggle.notification_widget.info.focus {
  color: #fff;
  background-color: #269abc;
  border-color: #1b6d85;
}
.notification_widget.info:active,
.notification_widget.info.active,
.open > .dropdown-toggle.notification_widget.info {
  background-image: none;
}
.notification_widget.info.disabled:hover,
.notification_widget.info[disabled]:hover,
fieldset[disabled] .notification_widget.info:hover,
.notification_widget.info.disabled:focus,
.notification_widget.info[disabled]:focus,
fieldset[disabled] .notification_widget.info:focus,
.notification_widget.info.disabled.focus,
.notification_widget.info[disabled].focus,
fieldset[disabled] .notification_widget.info.focus {
  background-color: #5bc0de;
  border-color: #46b8da;
}
.notification_widget.info .badge {
  color: #5bc0de;
  background-color: #fff;
}
.notification_widget.danger {
  color: #fff;
  background-color: #d9534f;
  border-color: #d43f3a;
}
.notification_widget.danger:focus,
.notification_widget.danger.focus {
  color: #fff;
  background-color: #c9302c;
  border-color: #761c19;
}
.notification_widget.danger:hover {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.notification_widget.danger:active,
.notification_widget.danger.active,
.open > .dropdown-toggle.notification_widget.danger {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.notification_widget.danger:active:hover,
.notification_widget.danger.active:hover,
.open > .dropdown-toggle.notification_widget.danger:hover,
.notification_widget.danger:active:focus,
.notification_widget.danger.active:focus,
.open > .dropdown-toggle.notification_widget.danger:focus,
.notification_widget.danger:active.focus,
.notification_widget.danger.active.focus,
.open > .dropdown-toggle.notification_widget.danger.focus {
  color: #fff;
  background-color: #ac2925;
  border-color: #761c19;
}
.notification_widget.danger:active,
.notification_widget.danger.active,
.open > .dropdown-toggle.notification_widget.danger {
  background-image: none;
}
.notification_widget.danger.disabled:hover,
.notification_widget.danger[disabled]:hover,
fieldset[disabled] .notification_widget.danger:hover,
.notification_widget.danger.disabled:focus,
.notification_widget.danger[disabled]:focus,
fieldset[disabled] .notification_widget.danger:focus,
.notification_widget.danger.disabled.focus,
.notification_widget.danger[disabled].focus,
fieldset[disabled] .notification_widget.danger.focus {
  background-color: #d9534f;
  border-color: #d43f3a;
}
.notification_widget.danger .badge {
  color: #d9534f;
  background-color: #fff;
}
div#pager {
  background-color: #fff;
  font-size: 14px;
  line-height: 20px;
  overflow: hidden;
  display: none;
  position: fixed;
  bottom: 0px;
  width: 100%;
  max-height: 50%;
  padding-top: 8px;
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  /* Display over codemirror */
  z-index: 100;
  /* Hack which prevents jquery ui resizable from changing top. */
  top: auto !important;
}
div#pager pre {
  line-height: 1.21429em;
  color: #000;
  background-color: #f7f7f7;
  padding: 0.4em;
}
div#pager #pager-button-area {
  position: absolute;
  top: 8px;
  right: 20px;
}
div#pager #pager-contents {
  position: relative;
  overflow: auto;
  width: 100%;
  height: 100%;
}
div#pager #pager-contents #pager-container {
  position: relative;
  padding: 15px 0px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
div#pager .ui-resizable-handle {
  top: 0px;
  height: 8px;
  background: #f7f7f7;
  border-top: 1px solid #cfcfcf;
  border-bottom: 1px solid #cfcfcf;
  /* This injects handle bars (a short, wide = symbol) for 
        the resize handle. */
}
div#pager .ui-resizable-handle::after {
  content: '';
  top: 2px;
  left: 50%;
  height: 3px;
  width: 30px;
  margin-left: -15px;
  position: absolute;
  border-top: 1px solid #cfcfcf;
}
.quickhelp {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
  line-height: 1.8em;
}
.shortcut_key {
  display: inline-block;
  width: 21ex;
  text-align: right;
  font-family: monospace;
}
.shortcut_descr {
  display: inline-block;
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
span.save_widget {
  margin-top: 6px;
}
span.save_widget span.filename {
  height: 1em;
  line-height: 1em;
  padding: 3px;
  margin-left: 16px;
  border: none;
  font-size: 146.5%;
  border-radius: 2px;
}
span.save_widget span.filename:hover {
  background-color: #e6e6e6;
}
span.checkpoint_status,
span.autosave_status {
  font-size: small;
}
@media (max-width: 767px) {
  span.save_widget {
    font-size: small;
  }
  span.checkpoint_status,
  span.autosave_status {
    display: none;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  span.checkpoint_status {
    display: none;
  }
  span.autosave_status {
    font-size: x-small;
  }
}
.toolbar {
  padding: 0px;
  margin-left: -5px;
  margin-top: 2px;
  margin-bottom: 5px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
.toolbar select,
.toolbar label {
  width: auto;
  vertical-align: middle;
  margin-right: 2px;
  margin-bottom: 0px;
  display: inline;
  font-size: 92%;
  margin-left: 0.3em;
  margin-right: 0.3em;
  padding: 0px;
  padding-top: 3px;
}
.toolbar .btn {
  padding: 2px 8px;
}
.toolbar .btn-group {
  margin-top: 0px;
  margin-left: 5px;
}
#maintoolbar {
  margin-bottom: -3px;
  margin-top: -8px;
  border: 0px;
  min-height: 27px;
  margin-left: 0px;
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<p><img src="../images/JHI_STRAP_Web.png" style="width: 150px; float: right;"></p>
<h1 id="04---Using-NCBI-BLAST+-Service--with-Biopython">04 - Using NCBI <code>BLAST+</code> Service  with Biopython<a class="anchor-link" href="#04---Using-NCBI-BLAST+-Service--with-Biopython">&#182;</a></h1>
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<h2 id="Learning-Outcomes">Learning Outcomes<a class="anchor-link" href="#Learning-Outcomes">&#182;</a></h2><ul>
<li>Use of <code>NCBI</code> remote <code>BLAST+</code> using Python and Biopython in the Jupyter notebook</li>
<li>Creating a remote <code>BLAST+</code> query, and its connection to running a <code>BLAST+</code> search on the server</li>
<li>Reading <code>BLAST+</code> output from the <code>NCBI</code> server into a Python variable</li>
<li>Using Entrez queries to customise your remote search</li>
<li>Computational analysis and visualisation of <code>BLAST+</code> output</li>
</ul>

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<h2 id="Table-of-Contents">Table of Contents<a class="anchor-link" href="#Table-of-Contents">&#182;</a></h2><ol>
<li><a href="#introduction">Introduction</a></li>
<li><a href="#imports">Python imports</a></li>
<li><a href="#blastx">Running and analysing a remote BLASTX search</a><ol>
<li><a href="#runblastx">Run <code>BLASTX</code></a></li>
<li><a href="#loadresults">Load <code>BLASTX</code> results</a></li>
<li><a href="#ex01">Exercise 01</a></li>
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<h2 id="Introduction">Introduction<a class="anchor-link" href="#Introduction">&#182;</a></h2><p><p></p></p>
<div class="alert-success">
<b>This notebook presents examples of methods for using `BLAST` programmatically, with the webservice provided by NCBI. All calculations will be run on NCBI's servers, using NCBI's databases (not your local `BLAST` installation), but you will be controlling the search using Python code in this notebook.</b>
</div><p>The advantages to using a programmatic interface for remote BLAST queries are the same as those listed in <a href="03-programming_for_blast">notebook 03</a>:</p>
<ul>
<li>It is easy to set up repeatable searches for many sequences, or collections of sequences</li>
<li>It is easy to read in the search results and conduct downstream analyses that add value to your search</li>
</ul>
<p>Where it is impractical to submit a large number of similar queries via a web form (because it is tiresome to point-and-click over and over again), this can be handled programmatically instead. You have the opportunity to change custom options to help refine your query, just as in the website interface. If you need to repeat a query, it can be trivial to get the same settings every time, if you use a programmatic approach.</p>

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<p><a id="imports"></a></p>
<h2 id="Python-imports">Python imports<a class="anchor-link" href="#Python-imports">&#182;</a></h2><p><p></p></p>
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<b>To interact with the NCBI's `BLAST` service, we will again use the free `Biopython` programming tools. These provide an interface to interact with NCBI's `BLAST` server, run jobs, and to retrieve the output files.</b>
</div><p>We import these tools, and some standard library packages for working with files (<code>os</code>) below.</p>

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<div class=" highlight hl-ipython3"><pre><span></span><span class="c1"># Show plots as part of the notebook</span>
<span class="o">%</span><span class="k">matplotlib</span> inline

<span class="c1"># Standard library packages</span>
<span class="kn">import</span> <span class="nn">os</span>

<span class="c1"># Import Biopython tools for running remote BLAST searches</span>
<span class="kn">from</span> <span class="nn">Bio.Blast</span> <span class="k">import</span> <span class="n">NCBIWWW</span>

<span class="c1"># Import Biopython SeqIO module to handle reading sequence data</span>
<span class="kn">from</span> <span class="nn">Bio</span> <span class="k">import</span> <span class="n">SeqIO</span>
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<p><a id="blastx"></a></p>
<h2 id="Running-and-analysing-a-remote-BLASTX-search">Running and analysing a remote BLASTX search<a class="anchor-link" href="#Running-and-analysing-a-remote-BLASTX-search">&#182;</a></h2><p><p></p></p>
<div class="alert-success">
<b>As in [notebook 03](03-programming_for_blast.ipynb), your first worked example will be to run a `BLASTX` search, querying a nucleotide sequence against a protein database, to identify potential homologues. What is different about this search is that you will be conducting it at NCBI, and using a different database.</b>
</div><p>You will use <code>Biopython</code> in the code blocks below to first perform the same <code>BLASTX</code> search you carried out in the exercise from <a href="01-blast_at_NCBI_website.ipynb">notebook 01</a> - this will query a lantibiotic biosynthesis protein from <em>Kitasatospora</em> against other <em>Kitasatospora</em> species - and write the results to file. Then you will parse the results into a <code>pandas</code> dataframe, and finally plot some summary statistics using <code>seaborn</code>.</p>

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<p><a id="runblastx"></a></p>
<h3 id="Run-BLASTX">Run <code>BLASTX</code><a class="anchor-link" href="#Run-BLASTX">&#182;</a></h3><p><p></p></p>
<div class="alert-success">
<b>Running a remote `BLAST` search with `Biopython` is, in some ways, simpler than running a local `BLAST` query. The key steps are:</b>
</div><ol>
<li>Read the query sequence(s) from a source (possibly a local file, but maybe a remote database)</li>
<li>Run a remote job with the <code>NCBIWWW.qblast()</code> method, specifying your query sequence, database, and <code>BLAST</code> program</li>
<li>Parse the output you get back from NCBI</li>
</ol>
<p>To run the remote job, you need the same kind of information as if you were running <code>BLAST</code> via the web interface - these arguments are compulsory:</p>
<ul>
<li>the <code>BLAST</code> program to use</li>
<li>query sequence(s) to search with</li>
<li>the database to search in</li>
</ul>
<p>but you can provide some extra choices when you run the remote job, including restricting the remote search on the basis of taxonomy, just as you did in the exercise from <code>notebook 01</code>.</p>

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<b>Firstly, you will obtain a query sequence for the search.</b>
</div><p>You will use the same penicillin-binding protein from <code>notebook 01</code>, reading it as before from a local file, but this time using <code>Biopython's</code> <code>SeqIO()</code> module.</p>
<p><p></p></p>
<div class="alert-warning">
<b>When data such as biological sequences are read in, their metadata - information on database IDs, and other features - follows them. `Biopython` does a nice job of showing us this information if we look at it with the `print()` function:</b>
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<div class=" highlight hl-ipython3"><pre><span></span><span class="c1"># Define path to data directory</span>
<span class="n">datadir</span> <span class="o">=</span> <span class="n">os</span><span class="o">.</span><span class="n">path</span><span class="o">.</span><span class="n">join</span><span class="p">(</span><span class="s2">&quot;data&quot;</span><span class="p">,</span> <span class="s2">&quot;kitasatospora&quot;</span><span class="p">)</span>

<span class="c1"># Load sequence of penicillin-binding protein, and inspect the information</span>
<span class="n">seqfile</span> <span class="o">=</span> <span class="n">os</span><span class="o">.</span><span class="n">path</span><span class="o">.</span><span class="n">join</span><span class="p">(</span><span class="n">datadir</span><span class="p">,</span> <span class="s2">&quot;k_sp_CB01950_penicillin.fasta&quot;</span><span class="p">)</span>
<span class="n">seq</span> <span class="o">=</span> <span class="n">SeqIO</span><span class="o">.</span><span class="n">read</span><span class="p">(</span><span class="n">seqfile</span><span class="p">,</span> <span class="s2">&quot;fasta&quot;</span><span class="p">)</span>
<span class="nb">print</span><span class="p">(</span><span class="n">seq</span><span class="p">)</span>
</pre></div>

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<pre>ID: lcl|LISX01000001.1_cds_OKJ16671.1_31
Name: lcl|LISX01000001.1_cds_OKJ16671.1_31
Description: lcl|LISX01000001.1_cds_OKJ16671.1_31 [locus_tag=AMK19_00175] [protein=penicillin-binding protein] [protein_id=OKJ16671.1] [location=39730..41184]
Number of features: 0
Seq(&#39;GTGAACAAGCCGATCCGCCGGGTGTCGATCTTCTGCCTGGTCCTGATCCTGGCC...TAG&#39;, SingleLetterAlphabet())
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<b>However, the remote `BLAST` server requires us to present our sequence in `FASTA` format!</b>
</div><p>One of the clever things about <code>Biopython</code>'s sequence objects - and a big advantage of using programmatic approaches - is that we can readily convert our sequence information into a number of different formats. To do this, we can use the sequence's <code>.format()</code> method to produce a <code>FASTA</code>-formatted string.</p>
<p>Doing this does not change the original sequence or its information in any way, but it creates a new presentation of that data, which we can use as our query:</p>

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<div class=" highlight hl-ipython3"><pre><span></span><span class="c1"># We need the sequence as a string, so use the .format() method</span>
<span class="nb">print</span><span class="p">(</span><span class="n">seq</span><span class="o">.</span><span class="n">format</span><span class="p">(</span><span class="s2">&quot;fasta&quot;</span><span class="p">))</span>
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<pre>&gt;lcl|LISX01000001.1_cds_OKJ16671.1_31 [locus_tag=AMK19_00175] [protein=penicillin-binding protein] [protein_id=OKJ16671.1] [location=39730..41184]
GTGAACAAGCCGATCCGCCGGGTGTCGATCTTCTGCCTGGTCCTGATCCTGGCCCTGATG
CTCCGGGTGAACTGGGTGCAGGGCGTTCAGGCGTCGACGTGGGCCAACAACCCGCACAAC
GACCGCACCAAGTACGACAAGTACGCCTACCCGCGCGGCAACATCATCGTCGGCGGCCAG
GCCGTCACCAAGTCCGACTTCGTCAACGGGCTGCGCTACAAGTACAAGCGCTCCTGGGTG
GACGGGCCGATGTACGCGCCGGTCACCGGCTACTCCTCGCAGACGTACGACGCCAGCCAG
CTGGAGAAGCTGGAGGACGGCATCCTCTCCGGCACCGACTCGCGGCTGTTCTTCCGCAAC
ACCCTGGACATGCTGACCGGCAAGCCCAAGCAGGGCGGCGACGTGGTCACCACCATCGAC
CCCAAGGTGCAGAAGGCCGGCTTCGAGGGGCTCGGCAACAAGAAGGGCGCCGCGGTCGCC
ATCGACCCGAAGACCGGGGCGATCCTCGGGCTGGTCTCCACCCCGTCCTACGACCCGGGC
ACCTTCGCGGGCGGCACCAAGGACGACGAGAAGGCCTGGACGGCACTCGACAGCGACCCG
AACAAGCCGATGCTGAACCGGGCGCTGCGCGAGACCTACCCGCCCGGCTCGACCTTCAAG
CTGGTCACCGCGGCGACCGCGTTCGAGACCGGCAAGTACCAGAGCCCGTCGGACGTCACC
GACACCCCGGACCAGTACATCCTGCCCGGCACCAGCACCCCGCTGATCAACGCCAGCCCC
ACCGAGGACTGCGGGAACGCCACCGTGCAACACGCGATGGACCTGTCCTGCAACACGGTG
TTCGGCAAGATGGGCGCCGAGCTGGGCGGCGACAAGCTGCGGGCGCAGGCCGAGAAGTTC
GGCTTCAACAAGGAAGTGACCATCCCGATCCGGGCCGACGCCAGCCACTTCCCGTCCGGC
TCCAAGCCCGACGGCACCGCGATGGACGCGATCGGCCAGCACGACACCCGGGCCACCCCG
CTGCAGATGGCCATGGTGGCCGCCGCGATCGCCAACAACGGCTCGCTGATGGAGCCCTAC
CTGGTCGCCCAGGAGGGCTCGGCCGGGAACGTGATCTCCACCCACACCGAGCACCAGCTG
TCGCAGGCGGTCTCGCCGGCCACCGCGCAGAAGCTCCAGCAGCTGATGGAGTCGGTGGTG
CAGCACGGCACCGGCACGAACGCGAAGATCCCGGGCGTGACGGTCGGCGGCAAGACCGGC
ACCGCCCAGCACGGCCAGGACAACTCGGGTCTGCCGTTCGCCTGGTTCGTCTCCTACGCC
AAGGGCCAGGACGGCAAGCAGGTCGCCGTCGCGGTGGTGGTCGAGGACGGCTCCAGCGAG
GCGCAGCAGATCTCCGGCGGCTCGCTGGCCGCGCCGATCGCCAAGGCGATGATGCAGGCG
GCGCTCGGGAAGTAG

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<b>You are now almost ready to build your remote `BLAST` query</b>
</div><p>The last two things you need to do are to consider the database we're going to search against, and the format you want the data returned in.</p>
<ul>
<li>You are going to query against the <code>pdbaa</code> database (which contains amino acid sequences for the set of proteins with known structures) as this is small, and should return a result fairly quickly. This is a useful way to identify protein structures that may be useful for threading or other analyses (structural analyses will be covered in session 04).</li>
<li>You are going to request <code>"Text"</code> format output, which will be easy for humans to read.</li>
</ul>
<p><p></p></p>
<div class="alert-warning">
<b>The search will return a special kind of object called a 'handle', which we still need to do some work with, to turn into a file, or read the results from.</b>
</div><p><p></p></p>
<div class="alert-danger">
<b>NOTE: the remote search may take some time.</b>
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<div class=" highlight hl-ipython3"><pre><span></span><span class="c1"># Run a remote BLASTX search, with the penicillin-binding protein as a query,</span>
<span class="c1"># against the pdbaa database, getting text output</span>
<span class="n">result_handle</span> <span class="o">=</span> <span class="n">NCBIWWW</span><span class="o">.</span><span class="n">qblast</span><span class="p">(</span><span class="s2">&quot;blastx&quot;</span><span class="p">,</span> <span class="s2">&quot;pdbaa&quot;</span><span class="p">,</span> <span class="n">seq</span><span class="o">.</span><span class="n">format</span><span class="p">(</span><span class="s2">&quot;fasta&quot;</span><span class="p">),</span>
                               <span class="n">format_type</span><span class="o">=</span><span class="s2">&quot;Text&quot;</span><span class="p">)</span>
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<p>Once the search has completed, you can <code>read()</code> the contents of the handle into a variable called <code>output</code>, and then inspect the contents using the <code>print()</code> function.</p>

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<div class=" highlight hl-ipython3"><pre><span></span><span class="c1"># Read the contents of the handle, and print to the cell</span>
<span class="n">output</span> <span class="o">=</span> <span class="n">result_handle</span><span class="o">.</span><span class="n">read</span><span class="p">()</span>
<span class="nb">print</span><span class="p">(</span><span class="n">output</span><span class="p">)</span>
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<pre>&lt;p&gt;&lt;!--
QBlastInfoBegin
	Status=READY
QBlastInfoEnd
--&gt;&lt;p&gt;
&lt;PRE&gt;
BLASTX 2.8.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro
A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and
David J. Lipman (1997), &#34;Gapped BLAST and PSI-BLAST: a new
generation of protein database search programs&#34;, Nucleic
Acids Res. 25:3389-3402.


RID: 9RXN2PZZ014


Database: PDB protein database
           97,497 sequences; 24,642,510 total letters
Query= lcl|LISX01000001.1_cds_OKJ16671.1_31 [locus_tag=AMK19_00175]
[protein=penicillin-binding protein] [protein_id=OKJ16671.1]
[location=39730..41184]

Length=1455


                                                                   Score     E
Sequences producing significant alignments:                       (Bits)  Value

3UN7_A  Chain A, Crystal Structure Of Pbpa From Mycobacterium ...  297     2e-95
3LO7_A  Chain A, Crystal structure of PBPA from Mycobacterium ...  295     2e-94
4MNR_A  Chain A, Crystal Structure Of D,d-transpeptidase Domai...  216     2e-64
4RA7_A  Chain A, Structure of a putative peptidoglycan glycosy...  128     6e-32
4N1X_A  Chain A, Structure of a putative peptidoglycan glycosy...  128     9e-32
4JBF_A  Chain A, Crystal structure of peptidoglycan glycosyltr...  128     9e-32
5E31_A  Chain A, 2.3 Angstrom Crystal Structure Of The Monomer...  115     4e-27
4CPK_A  Chain A, Crystal Structure Of Pbp2a Double Clinical Mu...  114     1e-26
1VQQ_A  Chain A, Structure Of Penicillin Binding Protein 2a Fr...  114     1e-26
4BL2_A  Chain A, Crystal Structure Of Pbp2a Clinical Mutant E1...  114     1e-26
3ZG5_A  Chain A, Crystal Structure Of Pbp2a From Mrsa In Compl...  114     1e-26
4BL3_A  Chain A, Crystal Structure Of Pbp2a Clinical Mutant N1...  112     4e-26
1MWS_A  Chain A, Structure Of Nitrocefin Acyl-Penicillin Bindi...  112     5e-26
1MWR_A  Chain A, Structure Of Semet Penicillin Binding Protein...  108     7e-25
3UE3_A  Chain A, Crystal Structure Of Acinetobacter Baumanni Pbp3  93.2    8e-20
5TRO_A  Chain A, 1.8 Angstrom Resolution Crystal Structure Of ...  91.7    3e-19
5UY7_A  Chain A, Crystal Structure Of A Peptidoglycan Glycosyl...  90.9    5e-19
5LP4_A  Chain A, Penicillin-Binding Protein (PBP2) from Helico...  89.0    2e-18
3EQV_A  Chain A, Crystal Structure Of Penicillin-binding Prote...  87.8    5e-18
3EQU_A  Chain A, Crystal Structure Of Penicillin-Binding Prote...  87.0    9e-18
5KSH_A  Chain A, Crystal Structure Of Penicillin-binding Prote...  85.9    2e-17
4L0L_A  Chain A, Crystal Structure Of P.aeruginosa Pbp3 In Com...  78.2    5e-15
3PBN_A  Chain A, Crystal Structure Of Apo Pbp3 From Pseudomona...  77.8    7e-15
4BJP_A  Chain A, Crystal Structure Of E. Coli Penicillin Bindi...  77.8    7e-15
4FSF_A  Chain A, Crystal Structure Of Pseudomonas Aeruginosa P...  77.8    7e-15
4WEK_A  Chain A, Crystal Structure Of Pseudomonas Aeruginosa P...  77.8    7e-15
3OC2_A  Chain A, Crystal Structure Of Penicillin-binding Prote...  77.8    9e-15
4ZTK_A  Chain A, Transpeptidase Domain Of Ftsi4 D,d-transpepti...  64.3    6e-11
4OVD_A  Chain A, Crystal structure of a putative peptidoglycan...  65.5    7e-11
4U3T_A  Chain A, Crystal Structure Of The Transpeptidase Domai...  60.1    2e-09
3ZG8_B  Chain B, Crystal Structure Of Penicillin Binding Prote...  60.5    2e-09
2WAF_A  Chain A, Penicillin-binding Protein 2b (pbp-2b) From S...  58.2    1e-08
2V2F_F  Chain F, Crystal Structure Of Pbp1a From Drug-resistan...  57.8    1e-08
2C5W_B  Chain B, Penicillin-Binding Protein 1a (Pbp-1a) Acyl-E...  55.8    6e-08
2ZC5_B  Chain B, Penicillin-Binding Protein 1a (Pbp 1a) Acyl-E...  55.1    1e-07
2C6W_B  Chain B, Penicillin-Binding Protein 1a (Pbp-1a) From S...  54.7    1e-07
3ZG7_B  Chain B, Crystal Structure Of Penicillin-binding Prote...  53.9    3e-07
2WAD_A  Chain A, Penicillin-binding Protein 2b (pbp-2b) From S...  53.5    4e-07
2WAE_A  Chain A, Penicillin-binding Protein 2b (pbp-2b) From S...  53.1    6e-07
3UDF_A  Chain A, Crystal Structure Of Apo Pbp1a From Acinetoba...  50.8    3e-06
1K25_A  Chain A, PBP2x from a Highly Penicillin-resistant Stre...  49.7    6e-06
5U47_A  Chain A, 1.95 Angstrom Resolution Crystal Structure Of...  48.9    1e-05
1RP5_A  Chain A, Pbp2x From Streptococcus Pneumoniae Strain 52...  47.4    4e-05
4OON_A  Chain A, Crystal Structure Of Pbp1a In Complex With Co...  46.6    7e-05
1PYY_A  Chain A, Double Mutant Pbp2x T338aM339F FROM STREPTOCO...  43.9    4e-04
1PMD_A  Chain A, Penicillin-Binding Protein 2x (Pbp-2x)            43.5    5e-04
1QME_A  Chain A, Penicillin-binding Protein 2x (pbp-2x)            43.1    7e-04
4YE5_A  Chain A, The Crystal Structure Of A Peptidoglycan Synt...  42.7    8e-04
3DWK_A  Chain A, Identification Of Dynamic Structural Motifs I...  42.4    0.001
2Z2L_B  Chain B, Penicillin-binding Protein 2x (pbp2x) From St...  40.4    0.004

ALIGNMENTS
&gt;3UN7_A Chain A, Crystal Structure Of Pbpa From Mycobacterium Tuberculosis
 3UN7_B Chain B, Crystal Structure Of Pbpa From Mycobacterium Tuberculosis
 3UPN_A Chain A, Structure Of Penicillin-Binding Protein A From M. Tuberculosis: 
Imipenem Acyl-Enzyme Complex
 3UPN_B Chain B, Structure Of Penicillin-Binding Protein A From M. Tuberculosis: 
Imipenem Acyl-Enzyme Complex
 3UPO_A Chain A, Structure Of Penicillin-Binding Protein A From M. Tuberculosis: 
Penicillin G Acyl-Enzyme Complex
 3UPO_B Chain B, Structure Of Penicillin-Binding Protein A From M. Tuberculosis: 
Penicillin G Acyl-Enzyme Complex
 3UPP_A Chain A, Structure Of Penicillin-Binding Protein A From M. Tuberculosis: 
Ceftrixaone Acyl-Enzyme Complex
 3UPP_B Chain B, Structure Of Penicillin-Binding Protein A From M. Tuberculosis: 
Ceftrixaone Acyl-Enzyme Complex
Length=462

 Score = 297 bits (760),  Expect = 2e-95, Method: Compositional matrix adjust.
 Identities = 192/461 (42%), Positives = 265/461 (57%), Gaps = 25/461 (5%)
 Frame = +1

Query  109   NPHNDRTKYDKYAYPRGNIIVGGQAVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTY  288
             +P N R   D+Y+  RG I  GGQ +  S   +G R+++ R + +  +YAPVTG+ S  Y
Sbjct  8     DPRNQRVLLDEYSRQRGQITAGGQLLAYSVATDG-RFRFLRVYPNPEVYAPVTGFYSLRY  66

Query  289   DASQLEKLEDGILSGTDSRLFFRNTLDMLTGKPKQGGDVVTTIDPKVQKAGFEGL-----  453
              ++ LE+ ED IL+G+D RLF R   D  TG+  +GG+V TTI+P++Q+AG++ +     
Sbjct  67    SSTALERAEDPILNGSDRRLFGRRLADFFTGRDPRGGNVDTTINPRIQQAGWDAMQQGCY  126

Query  454   GNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDE-KAWTALDSDPNKPMLNRALR  630
             G  KGA VA++P TG IL LVS+PSYDP   A    + + +AW  L  +P  P+ NRA+ 
Sbjct  127   GPCKGAVVALEPSTGKILALVSSPSYDPNLLASHNPEVQAQAWQRLGDNPASPLTNRAIS  186

Query  631   ETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTSTPLIN--ASPTEDCGNAT  804
             ETYPPGSTFK++T A A   G  ++   +T  P    LPG++  L N   +P  D    +
Sbjct  187   ETYPPGSTFKVITTAAALAAGATET-EQLTAAPT-IPLPGSTAQLENYGGAPCGDEPTVS  244

Query  805   VQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPSGSKPDGTA-  981
             ++ A   SCNT F ++G   G D LR+ A  FG +     P     +    G  PD  A 
Sbjct  245   LREAFVKSCNTAFVQLGIRTGADALRSMARAFGLDSPPR-PTPLQVAESTVGPIPDSAAL  303

Query  982   -MDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ-EGSAGNVISTHTEHQLSQAVS  1155
              M +IGQ D   TPL  A +AA IAN G  M PYLV   +G     IST   +Q  +AVS
Sbjct  304   GMTSIGQKDVALTPLANAEIAATIANGGITMRPYLVGSLKGPDLANISTTVRYQQRRAVS  363

Query  1156  PATAQKLQQLM---ESVVQHGTGTNAKIPGVTVGGKTGTAQHGQD-NSGLPFAWFVSYAK  1323
             P  A KL +LM   E V Q        IPGV +  KTGTA+HG D     P AW++++A 
Sbjct  364   PQVAAKLTELMVGAEKVAQQ----KGAIPGVQIASKTGTAEHGTDPRHTPPHAWYIAFAP  419

Query  1324  GQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAAL  1446
              Q  K VAVAV+VE+G+      +GG+LAAPI +A+++AAL
Sbjct  420   AQAPK-VAVAVLVENGADRLSA-TGGALAAPIGRAVIEAAL  458


&gt;3LO7_A Chain A, Crystal structure of PBPA from Mycobacterium tuberculosis
 3LO7_B Chain B, Crystal structure of PBPA from Mycobacterium tuberculosis
Length=483

 Score = 295 bits (755),  Expect = 2e-94, Method: Compositional matrix adjust.
 Identities = 192/461 (42%), Positives = 265/461 (57%), Gaps = 25/461 (5%)
 Frame = +1

Query  109   NPHNDRTKYDKYAYPRGNIIVGGQAVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTY  288
             +P N R   D+Y+  RG I  GGQ +  S   +G R+++ R + +  +YAPVTG+ S  Y
Sbjct  29    DPRNQRVLLDEYSRQRGQITAGGQLLAYSVATDG-RFRFLRVYPNPEVYAPVTGFYSLRY  87

Query  289   DASQLEKLEDGILSGTDSRLFFRNTLDMLTGKPKQGGDVVTTIDPKVQKAGFEGL-----  453
              ++ LE+ ED IL+G+D RLF R   D  TG+  +GG+V TTI+P++Q+AG++ +     
Sbjct  88    SSTALERAEDPILNGSDRRLFGRRLADFFTGRDPRGGNVDTTINPRIQQAGWDAMQQGCY  147

Query  454   GNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDE-KAWTALDSDPNKPMLNRALR  630
             G  KGA VA++P TG IL LVS+PSYDP   A    + + +AW  L  +P  P+ NRA+ 
Sbjct  148   GPCKGAVVALEPSTGKILALVSSPSYDPNLLASHNPEVQAQAWQRLGDNPASPLTNRAIS  207

Query  631   ETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTSTPLIN--ASPTEDCGNAT  804
             ETYPPGSTFK++T A A   G  ++   +T  P    LPG++  L N   +P  D    +
Sbjct  208   ETYPPGSTFKVITTAAALAAGATET-EQLTAAPT-IPLPGSTAQLENYGGAPCGDEPTVS  265

Query  805   VQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPSGSKPDGTA-  981
             ++ A   SCNT F ++G   G D LR+ A  FG +     P     +    G  PD  A 
Sbjct  266   LREAFVKSCNTAFVQLGIRTGADALRSMARAFGLDSPPR-PTPLQVAESTVGPIPDSAAL  324

Query  982   -MDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ-EGSAGNVISTHTEHQLSQAVS  1155
              M +IGQ D   TPL  A +AA IAN G  M PYLV   +G     IST   +Q  +AVS
Sbjct  325   GMTSIGQKDVALTPLANAEIAATIANGGITMRPYLVGSLKGPDLANISTTVGYQQRRAVS  384

Query  1156  PATAQKLQQLM---ESVVQHGTGTNAKIPGVTVGGKTGTAQHGQD-NSGLPFAWFVSYAK  1323
             P  A KL +LM   E V Q        IPGV +  KTGTA+HG D     P AW++++A 
Sbjct  385   PQVAAKLTELMVGAEKVAQQ----KGAIPGVQIASKTGTAEHGTDPRHTPPHAWYIAFAP  440

Query  1324  GQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAAL  1446
              Q  K VAVAV+VE+G+      +GG+LAAPI +A+++AAL
Sbjct  441   AQAPK-VAVAVLVENGADRLSA-TGGALAAPIGRAVIEAAL  479


&gt;4MNR_A Chain A, Crystal Structure Of D,d-transpeptidase Domain Of Peptidoglycan 
Glycosyltransferase From Eggerthella Lenta
Length=457

 Score = 216 bits (550),  Expect = 2e-64, Method: Compositional matrix adjust.
 Identities = 167/457 (37%), Positives = 236/457 (52%), Gaps = 54/457 (12%)
 Frame = +1

Query  85    VQASTWANNPHNDRTKYDKYAYPRGNI-----IVGGQAVTKSDFVNGLRYKYKRSWVDGP  249
             VQA  + N P N+ T   +    RG I     +V  ++V + D        Y+R +  G 
Sbjct  4     VQADYYQNXPGNNHTLAKEARSERGTIATYDGVVLARSVKEEDGT------YEREYPAGD  57

Query  250   MYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDMLTGKPKQGGDVVTTIDPKV  429
             + + V GYSS  +  S +EK  +  L G ++   + + L+   G    G DV  T++ K+
Sbjct  58    LASHVVGYSSPQFGNSGIEKAYNDTLKGEENFASWTDVLNSFAGIGTAGNDVTLTLNSKI  117

Query  430   QKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKP  609
             Q+A  + L  +KGA V  DP TGAIL   S P+Y+   FA      E+A    +++P+  
Sbjct  118   QQAAQDALAGRKGACVVXDPDTGAILAXASAPTYNAADFAAVI---EQA----NANPDDS  170

Query  610   ML-NRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTSTPLINASPTE  786
              L +RA    Y PGSTFK+VT ATA E        DV      +  PGT   + NA+ + 
Sbjct  171   TLVDRAAGSLYAPGSTFKIVTLATALE-------DDVAGEDTVFSSPGTXE-IGNATVSN  222

Query  787   ----DCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFP  954
                 + G+ T+  A +LS NTVFG++G E G DKL A AE FGFNKE+  P+    S  P
Sbjct  223   FNKANYGSLTLAQATELSSNTVFGQLGVEXGADKLVAGAESFGFNKEIDFPLYTPESLXP  282

Query  955   SGS----KPDGTAMDAIGQ--HDT-----------RATPLQMAMVAAAIANNGSLMEPYL  1083
             S       P   A  A G+   DT           +AT L+ A V  AIAN+G + +PYL
Sbjct  283   SAEDLQKSPWELAWAAAGEPVGDTTRPGRESPAGPQATVLEXAXVGTAIANDGVIXQPYL  342

Query  1084  VAQEGSA-GNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTG  1260
             V    +A G    + +  +L QAVS  TA +++ ++  VVQ+GTGT A IPG+ V GKTG
Sbjct  343   VDSVNNANGERSFSASPTKLXQAVSKTTAGRVRDVLLGVVQNGTGTAAAIPGIDVAGKTG  402

Query  1261  TAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDG  1371
             TA+    N     +WFV  A  +D  +V VA+V+EDG
Sbjct  403   TAEKENGND----SWFVGXAPAED-PRVVVAIVIEDG  434


&gt;4RA7_A Chain A, Structure of a putative peptidoglycan glycosyltransferase 
from Atopobium parvulum in complex with nafcillin
 4RA7_B Chain B, Structure of a putative peptidoglycan glycosyltransferase 
from Atopobium parvulum in complex with nafcillin
Length=453

 Score = 128 bits (321),  Expect = 6e-32, Method: Compositional matrix adjust.
 Identities = 131/434 (30%), Positives = 196/434 (45%), Gaps = 40/434 (9%)
 Frame = +1

Query  112   PHNDRTKYDKYAYPRGNIIVGGQAVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYD  291
             P N+ T   K AY +   I+    VT ++ V      Y R++      +   GY S  Y 
Sbjct  13    PTNNHT-IAKSAYVQRGAIITSDGVTLAESVKQDDGTYVRNYPHDGXASHTVGYISTQYG  71

Query  292   ASQLEKLEDGILSGTDSRLFFRNTLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGA  471
              + +E   +  L+G      +R+ L    G    G  VV TI+ + Q      L    G+
Sbjct  72    TAGIESSXNETLTGHADHSDWRSALYSXAGINTTGSSVVLTINSQXQAVAEAALQGYSGS  131

Query  472   AVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGS  651
              V  DP TGA+L   S+PSY                T ++S     +++R  +  Y PGS
Sbjct  132   IVVXDPSTGAVLAKASSPSYTHAELG----------TIIESGTGSQLVDRTTQALYSPGS  181

Query  652   TFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTST---PLINASPTEDCGNATVQHAMD  822
             +FK VT A   +T K       T     Y  PGT       I+    ED G   ++ A  
Sbjct  182   SFKTVTLAAGIDTHK-------TTLDTTYSAPGTXEIGGGTIHNYANEDXGTIPLREAFA  234

Query  823   LSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPSGSKPD------GTAM  984
              S NT   ++G  LG D L + A  FG+   +        S  P+ ++         +  
Sbjct  235   RSSNTALAQLGVALGADNLVSYARAFGYGTALGQDFSTTPSLXPNPAEXTTWELAWASCG  294

Query  985   DAIGQHDTRATP----LQMAMVAAAIANNGSLMEPYLVAQEGS-AGNVISTHTEHQLSQA  1149
               +G+H + A P     Q A++AAAIAN G +  PY+V +  S  G V+ST +   L QA
Sbjct  295   LPVGEHASPAGPQTTVXQNAVIAAAIANGGVVXNPYIVDRVLSPEGAVVSTTSPKSLGQA  354

Query  1150  VSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTA--QHGQDNSGLPFAWFVSYAK  1323
             VS  TA ++++    VV+ GTG  A++PGV + GKTGTA  ++G  NS     +F+ +A 
Sbjct  355   VSADTAAQVREAXLGVVESGTGXGARVPGVKIAGKTGTADVENGNFNS-----FFIGFAP  409

Query  1324  GQDGKQVAVAVVVE  1365
               D   + V+VV+E
Sbjct  410   -YDHPTLVVSVVIE  422


&gt;4N1X_A Chain A, Structure of a putative peptidoglycan glycosyltransferase 
from Atopobium parvulum in complex with penicillin G
 4N1X_B Chain B, Structure of a putative peptidoglycan glycosyltransferase 
from Atopobium parvulum in complex with penicillin G
Length=472

 Score = 128 bits (321),  Expect = 9e-32, Method: Compositional matrix adjust.
 Identities = 132/445 (30%), Positives = 201/445 (45%), Gaps = 40/445 (9%)
 Frame = +1

Query  79    QGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKSDFVNGLRYKYKRSWVDGPMYA  258
             +G +   + +N  N+ T   K AY +   I+    VT ++ V      Y R++      +
Sbjct  21    KGTENLYFQSNATNNHT-IAKSAYVQRGAIITSDGVTLAESVKQDDGTYVRNYPHDGXAS  79

Query  259   PVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDMLTGKPKQGGDVVTTIDPKVQKA  438
                GY S  Y  + +E   +  L+G      +R+ L    G    G  VV TI+ + Q  
Sbjct  80    HTVGYISTQYGTAGIESSXNETLTGHADHSDWRSALYSXAGINTTGSSVVLTINSQXQAV  139

Query  439   GFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLN  618
                 L    G+ V  DP TGA+L   S+PSY                T ++S     +++
Sbjct  140   AEAALQGYSGSIVVXDPSTGAVLAKASSPSYTHAELG----------TIIESGTGSQLVD  189

Query  619   RALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTST---PLINASPTED  789
             R  +  Y PGS+FK VT A   +T K       T     Y  PGT       I+    ED
Sbjct  190   RTTQALYSPGSSFKTVTLAAGIDTHK-------TTLDTTYSAPGTXEIGGGTIHNYANED  242

Query  790   CGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPSGSKP  969
              G   ++ A   S NT   ++G  LG D L + A  FG+   +        S  P+ ++ 
Sbjct  243   XGTIPLREAFARSSNTALAQLGVALGADNLVSYARAFGYGTALGQDFSTTPSLXPNPAEX  302

Query  970   D------GTAMDAIGQHDTRATP----LQMAMVAAAIANNGSLMEPYLVAQEGS-AGNVI  1116
                     +    +G+H + A P     Q A++AAAIAN G +  PY+V +  S  G V+
Sbjct  303   TTWELAWASCGLPVGEHASPAGPQTTVXQNAVIAAAIANGGVVXNPYIVDRVLSPEGAVV  362

Query  1117  STHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTA--QHGQDNSG  1290
             ST +   L QAVS  TA ++++    VV+ GTG  A++PGV + GKTGTA  ++G  NS 
Sbjct  363   STTSPKSLGQAVSADTAAQVREAXLGVVESGTGXGARVPGVKIAGKTGTADVENGNFNS-  421

Query  1291  LPFAWFVSYAKGQDGKQVAVAVVVE  1365
                 +F+ +A   D   + V+VV+E
Sbjct  422   ----FFIGFAP-YDHPTLVVSVVIE  441


&gt;4JBF_A Chain A, Crystal structure of peptidoglycan glycosyltransferase 
from Atopobium parvulum DSM 20469.
 4JBF_B Chain B, Crystal structure of peptidoglycan glycosyltransferase 
from Atopobium parvulum DSM 20469.
 4QJG_A Chain A, Structure of a putative peptidoglycan glycosyltransferase 
from Atopobium parvulum in complex with penicillin V
 4QJG_B Chain B, Structure of a putative peptidoglycan glycosyltransferase 
from Atopobium parvulum in complex with penicillin V
 4R0Q_A Chain A, Structure of a putative peptidoglycan glycosyltransferase 
from Atopobium parvulum in complex with cephalothin
 4R0Q_B Chain B, Structure of a putative peptidoglycan glycosyltransferase 
from Atopobium parvulum in complex with cephalothin
 4R1G_A Chain A, Structure of a putative peptidoglycan glycosyltransferase 
from Atopobium parvulum in complex with cloxacillin
 4R1G_B Chain B, Structure of a putative peptidoglycan glycosyltransferase 
from Atopobium parvulum in complex with cloxacillin
 4R23_A Chain A, Structure of a putative peptidoglycan glycosyltransferase 
from Atopobium parvulum in complex with dicloxacillin
 4R23_B Chain B, Structure of a putative peptidoglycan glycosyltransferase 
from Atopobium parvulum in complex with dicloxacillin
 4R3J_A Chain A, Structure of a putative peptidoglycan glycosyltransferase 
from Atopobium parvulum in complex with cefapirin
 4R3J_B Chain B, Structure of a putative peptidoglycan glycosyltransferase 
from Atopobium parvulum in complex with cefapirin
Length=482

 Score = 128 bits (321),  Expect = 9e-32, Method: Compositional matrix adjust.
 Identities = 131/434 (30%), Positives = 196/434 (45%), Gaps = 40/434 (9%)
 Frame = +1

Query  112   PHNDRTKYDKYAYPRGNIIVGGQAVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYD  291
             P N+ T   K AY +   I+    VT ++ V      Y R++      +   GY S  Y 
Sbjct  42    PTNNHT-IAKSAYVQRGAIITSDGVTLAESVKQDDGTYVRNYPHDGXASHTVGYISTQYG  100

Query  292   ASQLEKLEDGILSGTDSRLFFRNTLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGA  471
              + +E   +  L+G      +R+ L    G    G  VV TI+ + Q      L    G+
Sbjct  101   TAGIESSXNETLTGHADHSDWRSALYSXAGINTTGSSVVLTINSQXQAVAEAALQGYSGS  160

Query  472   AVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGS  651
              V  DP TGA+L   S+PSY                T ++S     +++R  +  Y PGS
Sbjct  161   IVVXDPSTGAVLAKASSPSYTHAELG----------TIIESGTGSQLVDRTTQALYSPGS  210

Query  652   TFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTST---PLINASPTEDCGNATVQHAMD  822
             +FK VT A   +T K       T     Y  PGT       I+    ED G   ++ A  
Sbjct  211   SFKTVTLAAGIDTHK-------TTLDTTYSAPGTXEIGGGTIHNYANEDXGTIPLREAFA  263

Query  823   LSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPSGSKPD------GTAM  984
              S NT   ++G  LG D L + A  FG+   +        S  P+ ++         +  
Sbjct  264   RSSNTALAQLGVALGADNLVSYARAFGYGTALGQDFSTTPSLXPNPAEXTTWELAWASCG  323

Query  985   DAIGQHDTRATP----LQMAMVAAAIANNGSLMEPYLVAQEGS-AGNVISTHTEHQLSQA  1149
               +G+H + A P     Q A++AAAIAN G +  PY+V +  S  G V+ST +   L QA
Sbjct  324   LPVGEHASPAGPQTTVXQNAVIAAAIANGGVVXNPYIVDRVLSPEGAVVSTTSPKSLGQA  383

Query  1150  VSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTA--QHGQDNSGLPFAWFVSYAK  1323
             VS  TA ++++    VV+ GTG  A++PGV + GKTGTA  ++G  NS     +F+ +A 
Sbjct  384   VSADTAAQVREAXLGVVESGTGXGARVPGVKIAGKTGTADVENGNFNS-----FFIGFAP  438

Query  1324  GQDGKQVAVAVVVE  1365
               D   + V+VV+E
Sbjct  439   -YDHPTLVVSVVIE  451


&gt;5E31_A Chain A, 2.3 Angstrom Crystal Structure Of The Monomeric Form 
Of Penicillin Binding Protein 2 Prime From Enterococcus Faecium.
Length=644

 Score = 115 bits (289),  Expect = 4e-27, Method: Compositional matrix adjust.
 Identities = 98/343 (29%), Positives = 158/343 (46%), Gaps = 29/343 (8%)
 Frame = +1

Query  319   GILSGTDSRLFFRNTLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTG  498
             G LS TD+    +  L  +  + + G D+  TID K QK  F+ LG K G+ VA  PKTG
Sbjct  283   GKLSITDADGVEKKVL--IEHEVQNGKDIKLTIDAKAQKTAFDSLGGKAGSTVATTPKTG  340

Query  499   AILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAAT  678
              +L L S+PSYDP     G   ++  + A + +P +P ++R     Y PGSTFK +TAA 
Sbjct  341   DLLALASSPSYDPNKXTNGISQED--YKAYEENPEQPFISR-FATGYAPGSTFKXITAAI  397

Query  679   AFETGKYQSPSDVTDTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGA  858
               + G    P++V           +S      +   D     ++ A+  S N    +   
Sbjct  398   GLDNGTI-DPNEVLTINGLKWQKDSSWGSYQVTRVSDVSQVDLKTALIYSDNIYXAQETL  456

Query  859   ELGGDKLRAQAEKFGFNKEVTIPIRADASHFPSGSKPDGTAMDAI------GQHDTRATP  1020
             + G  K R   +KF F +++ +PI  + +     S  D    D +      GQ +    P
Sbjct  457   KXGEKKFRTGLDKFIFGEDLDLPISXNPAQI---SNEDSFNSDILLADTGYGQGELLINP  513

Query  1021  LQMAMVAAAIANNGSLMEPYLVAQEGSAG--NVISTHTEHQLSQAVSPATAQKLQQLMES  1194
             +Q A   +  ANNG+L+ P L+A + +    NVI         Q + P     L+++++ 
Sbjct  514   IQQAAXYSVFANNGTLVYPKLIADKETKDKKNVIG----ETAVQTIVP----DLREVVQD  565

Query  1195  VVQHGTGTNAKIPGVTVGGKTGTAQ--HGQDNSGLPFAWFVSY  1317
             V  +GT  +    G+ +  KTGTA+    QD  G   ++  ++
Sbjct  566   V--NGTAHSLSALGIPLAAKTGTAEIKEKQDEKGKENSFLFAF  606


&gt;4CPK_A Chain A, Crystal Structure Of Pbp2a Double Clinical Mutant N146k- 
E150k From Mrsa
 4CPK_B Chain B, Crystal Structure Of Pbp2a Double Clinical Mutant N146k- 
E150k From Mrsa
Length=643

 Score = 114 bits (285),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 107/384 (28%), Positives = 165/384 (43%), Gaps = 59/384 (15%)
 Frame = +1

Query  301   LEKLEDGILSGTDSRLFFRNTL----------DMLTGKPKQGGDVVTTIDPKVQKAGFEG  450
             LEKL D  L   D    +R T+           ++  K K G D+  TID KVQK+ +  
Sbjct  258   LEKLYDKKLQHEDG---YRVTIVDDNSNTIAHTLIEKKKKDGKDIQLTIDAKVQKSIYNN  314

Query  451   LGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALR  630
             + N  G+  AI P+TG +L LVSTPSYD   F  G  ++E  +  L  D  +P+LN+  +
Sbjct  315   MKNDYGSGTAIHPQTGELLALVSTPSYDVYPFMYGMSNEE--YNKLTEDKKEPLLNK-FQ  371

Query  631   ETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPG------TSTPLINASPTEDC  792
              T  PGST K++TA            +   D    Y + G       S    N +  E  
Sbjct  372   ITTSPGSTQKILTAMIGLN-------NKTLDDKTSYKIDGKGWQKDKSWGGYNVTRYEVV  424

Query  793   -GNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFP-----  954
              GN  ++ A++ S N  F ++  ELG  K     +K G  +++        S +P     
Sbjct  425   NGNIDLKQAIESSDNIFFARVALELGSKKFEKGMKKLGVGEDI-------PSDYPFYNAQ  477

Query  955   -SGSKPDGTAMDA---IGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSAGNVIST  1122
              S    D   + A    GQ +    P+Q+  + +A+ NNG++  P+L+           T
Sbjct  478   ISNKNLDNEILLADSGYGQGEILINPVQILSIYSALENNGNINAPHLLK---------DT  528

Query  1123  HTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ--HGQDNSGLP  1296
               +      +S      L   M+ VV      +       + GK+GTA+    Q  +G  
Sbjct  529   KNKVWKKNIISKENINLLTDGMQQVVNKTHKEDIYRSYANLIGKSGTAELKMKQGETGRQ  588

Query  1297  FAWFVSYAKGQDGKQVAVAVVVED  1368
               WF+SY K  D   + +A+ V+D
Sbjct  589   IGWFISYDK--DNPNMMMAINVKD  610


&gt;1VQQ_A Chain A, Structure Of Penicillin Binding Protein 2a From Methicillin 
Resistant Staphylococcus Aureus Strain 27r At 1.80 A 
Resolution.
 1VQQ_B Chain B, Structure Of Penicillin Binding Protein 2a From Methicillin 
Resistant Staphylococcus Aureus Strain 27r At 1.80 A 
Resolution.
 1MWU_A Chain A, Structure Of Methicillin Acyl-Penicillin Binding Protein 
2a From Methicillin Resistant Staphylococcus Aureus Strain 
27r At 2.60 A Resolution.
 1MWU_B Chain B, Structure Of Methicillin Acyl-Penicillin Binding Protein 
2a From Methicillin Resistant Staphylococcus Aureus Strain 
27r At 2.60 A Resolution.
 4DKI_A Chain A, Structural Insights Into The Anti- Methicillin-Resistant 
Staphylococcus Aureus (Mrsa) Activity Of Ceftobiprole
 4DKI_B Chain B, Structural Insights Into The Anti- Methicillin-Resistant 
Staphylococcus Aureus (Mrsa) Activity Of Ceftobiprole
Length=646

 Score = 114 bits (285),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 107/384 (28%), Positives = 165/384 (43%), Gaps = 59/384 (15%)
 Frame = +1

Query  301   LEKLEDGILSGTDSRLFFRNTL----------DMLTGKPKQGGDVVTTIDPKVQKAGFEG  450
             LEKL D  L   D    +R T+           ++  K K G D+  TID KVQK+ +  
Sbjct  261   LEKLYDKKLQHEDG---YRVTIVDDNSNTIAHTLIEKKKKDGKDIQLTIDAKVQKSIYNN  317

Query  451   LGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALR  630
             + N  G+  AI P+TG +L LVSTPSYD   F  G  ++E  +  L  D  +P+LN+  +
Sbjct  318   MKNDYGSGTAIHPQTGELLALVSTPSYDVYPFMYGMSNEE--YNKLTEDKKEPLLNK-FQ  374

Query  631   ETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPG------TSTPLINASPTEDC  792
              T  PGST K++TA            +   D    Y + G       S    N +  E  
Sbjct  375   ITTSPGSTQKILTAMIGLN-------NKTLDDKTSYKIDGKGWQKDKSWGGYNVTRYEVV  427

Query  793   -GNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFP-----  954
              GN  ++ A++ S N  F ++  ELG  K     +K G  +++        S +P     
Sbjct  428   NGNIDLKQAIESSDNIFFARVALELGSKKFEKGMKKLGVGEDI-------PSDYPFYNAQ  480

Query  955   -SGSKPDGTAMDA---IGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSAGNVIST  1122
              S    D   + A    GQ +    P+Q+  + +A+ NNG++  P+L+           T
Sbjct  481   ISNKNLDNEILLADSGYGQGEILINPVQILSIYSALENNGNINAPHLLK---------DT  531

Query  1123  HTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ--HGQDNSGLP  1296
               +      +S      L   M+ VV      +       + GK+GTA+    Q  +G  
Sbjct  532   KNKVWKKNIISKENINLLTDGMQQVVNKTHKEDIYRSYANLIGKSGTAELKMKQGETGRQ  591

Query  1297  FAWFVSYAKGQDGKQVAVAVVVED  1368
               WF+SY K  D   + +A+ V+D
Sbjct  592   IGWFISYDK--DNPNMMMAINVKD  613


&gt;4BL2_A Chain A, Crystal Structure Of Pbp2a Clinical Mutant E150k From 
Mrsa
 4BL2_B Chain B, Crystal Structure Of Pbp2a Clinical Mutant E150k From 
Mrsa
Length=643

 Score = 114 bits (285),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 107/384 (28%), Positives = 165/384 (43%), Gaps = 59/384 (15%)
 Frame = +1

Query  301   LEKLEDGILSGTDSRLFFRNTL----------DMLTGKPKQGGDVVTTIDPKVQKAGFEG  450
             LEKL D  L   D    +R T+           ++  K K G D+  TID KVQK+ +  
Sbjct  258   LEKLYDKKLQHEDG---YRVTIVDDNSNTIAHTLIEKKKKDGKDIQLTIDAKVQKSIYNN  314

Query  451   LGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALR  630
             + N  G+  AI P+TG +L LVSTPSYD   F  G  ++E  +  L  D  +P+LN+  +
Sbjct  315   MKNDYGSGTAIHPQTGELLALVSTPSYDVYPFMYGMSNEE--YNKLTEDKKEPLLNK-FQ  371

Query  631   ETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPG------TSTPLINASPTEDC  792
              T  PGST K++TA            +   D    Y + G       S    N +  E  
Sbjct  372   ITTSPGSTQKILTAMIGLN-------NKTLDDKTSYKIDGKGWQKDKSWGGYNVTRYEVV  424

Query  793   -GNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFP-----  954
              GN  ++ A++ S N  F ++  ELG  K     +K G  +++        S +P     
Sbjct  425   NGNIDLKQAIESSDNIFFARVALELGSKKFEKGMKKLGVGEDI-------PSDYPFYNAQ  477

Query  955   -SGSKPDGTAMDA---IGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSAGNVIST  1122
              S    D   + A    GQ +    P+Q+  + +A+ NNG++  P+L+           T
Sbjct  478   ISNKNLDNEILLADSGYGQGEILINPVQILSIYSALENNGNINAPHLLK---------DT  528

Query  1123  HTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ--HGQDNSGLP  1296
               +      +S      L   M+ VV      +       + GK+GTA+    Q  +G  
Sbjct  529   KNKVWKKNIISKENINLLTDGMQQVVNKTHKEDIYRSYANLIGKSGTAELKMKQGETGRQ  588

Query  1297  FAWFVSYAKGQDGKQVAVAVVVED  1368
               WF+SY K  D   + +A+ V+D
Sbjct  589   IGWFISYDK--DNPNMMMAINVKD  610


&gt;3ZG5_A Chain A, Crystal Structure Of Pbp2a From Mrsa In Complex With 
Peptidoglycan Analogue At Allosteric
 3ZG5_B Chain B, Crystal Structure Of Pbp2a From Mrsa In Complex With 
Peptidoglycan Analogue At Allosteric
 3ZG0_A Chain A, Crystal Structure Of Ceftaroline Acyl-pbp2a From Mrsa 
With Non-covalently Bound Ceftaroline And Muramic Acid At 
Allosteric Site Obtained By Cocrystallization
 3ZG0_B Chain B, Crystal Structure Of Ceftaroline Acyl-pbp2a From Mrsa 
With Non-covalently Bound Ceftaroline And Muramic Acid At 
Allosteric Site Obtained By Cocrystallization
 3ZFZ_A Chain A, Crystal Structure Of Ceftaroline Acyl-pbp2a From Mrsa 
With Non-covalently Bound Ceftaroline And Muramic Acid At 
Allosteric Site Obtained By Soaking
 3ZFZ_B Chain B, Crystal Structure Of Ceftaroline Acyl-pbp2a From Mrsa 
With Non-covalently Bound Ceftaroline And Muramic Acid At 
Allosteric Site Obtained By Soaking
 4CJN_A Chain A, Crystal Structure Of Pbp2a From Mrsa In Complex With 
Quinazolinone Ligand
 4CJN_B Chain B, Crystal Structure Of Pbp2a From Mrsa In Complex With 
Quinazolinone Ligand
 5M18_A Chain A, Crystal structure of PBP2a from MRSA in the presence 
of Cefepime ligand
 5M18_B Chain B, Crystal structure of PBP2a from MRSA in the presence 
of Cefepime ligand
 5M19_A Chain A, Crystal structure of PBP2a from MRSA in the presence 
of Oxacillin ligand
 5M19_B Chain B, Crystal structure of PBP2a from MRSA in the presence 
of Oxacillin ligand
 5M1A_A Chain A, Crystal structure of PBP2a from MRSA in the presence 
of Ceftazidime ligand
 5M1A_B Chain B, Crystal structure of PBP2a from MRSA in the presence 
of Ceftazidime ligand
Length=642

 Score = 114 bits (285),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 107/384 (28%), Positives = 165/384 (43%), Gaps = 59/384 (15%)
 Frame = +1

Query  301   LEKLEDGILSGTDSRLFFRNTL----------DMLTGKPKQGGDVVTTIDPKVQKAGFEG  450
             LEKL D  L   D    +R T+           ++  K K G D+  TID KVQK+ +  
Sbjct  257   LEKLYDKKLQHEDG---YRVTIVDDNSNTIAHTLIEKKKKDGKDIQLTIDAKVQKSIYNN  313

Query  451   LGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALR  630
             + N  G+  AI P+TG +L LVSTPSYD   F  G  ++E  +  L  D  +P+LN+  +
Sbjct  314   MKNDYGSGTAIHPQTGELLALVSTPSYDVYPFMYGMSNEE--YNKLTEDKKEPLLNK-FQ  370

Query  631   ETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPG------TSTPLINASPTEDC  792
              T  PGST K++TA            +   D    Y + G       S    N +  E  
Sbjct  371   ITTSPGSTQKILTAMIGLN-------NKTLDDKTSYKIDGKGWQKDKSWGGYNVTRYEVV  423

Query  793   -GNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFP-----  954
              GN  ++ A++ S N  F ++  ELG  K     +K G  +++        S +P     
Sbjct  424   NGNIDLKQAIESSDNIFFARVALELGSKKFEKGMKKLGVGEDI-------PSDYPFYNAQ  476

Query  955   -SGSKPDGTAMDA---IGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSAGNVIST  1122
              S    D   + A    GQ +    P+Q+  + +A+ NNG++  P+L+           T
Sbjct  477   ISNKNLDNEILLADSGYGQGEILINPVQILSIYSALENNGNINAPHLLK---------DT  527

Query  1123  HTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ--HGQDNSGLP  1296
               +      +S      L   M+ VV      +       + GK+GTA+    Q  +G  
Sbjct  528   KNKVWKKNIISKENINLLTDGMQQVVNKTHKEDIYRSYANLIGKSGTAELKMKQGETGRQ  587

Query  1297  FAWFVSYAKGQDGKQVAVAVVVED  1368
               WF+SY K  D   + +A+ V+D
Sbjct  588   IGWFISYDK--DNPNMMMAINVKD  609


&gt;4BL3_A Chain A, Crystal Structure Of Pbp2a Clinical Mutant N146k From 
Mrsa
 4BL3_B Chain B, Crystal Structure Of Pbp2a Clinical Mutant N146k From 
Mrsa
Length=640

 Score = 112 bits (281),  Expect = 4e-26, Method: Compositional matrix adjust.
 Identities = 106/382 (28%), Positives = 163/382 (43%), Gaps = 58/382 (15%)
 Frame = +1

Query  301   LEKLEDGILSGTDSRLFFRNTL----------DMLTGKPKQGGDVVTTIDPKVQKAGFEG  450
             LEKL D  L   D    +R T+           ++  K K G D+  TID KVQK+ +  
Sbjct  258   LEKLYDKKLQHEDG---YRVTIVDDNSNTIAHTLIEKKKKDGKDIQLTIDAKVQKSIYNN  314

Query  451   LGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALR  630
             + N  G+  AI P+TG +L LVSTPSYD   F  G  ++E  +  L  D  +P+LN+  +
Sbjct  315   MKNDYGSGTAIHPQTGELLALVSTPSYDVYPFMYGMSNEE--YNKLTEDKKEPLLNK-FQ  371

Query  631   ETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPG------TSTPLINASPTEDC  792
              T  PGST K++TA            +   D    Y + G       S    N +  E  
Sbjct  372   ITTSPGSTQKILTAMIGLN-------NKTLDDKTSYKIDGKGWQKDKSWGGYNVTRYEVV  424

Query  793   -GNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFP-----  954
              GN  ++ A++ S N  F ++  ELG  K     +K G  +++        S +P     
Sbjct  425   NGNIDLKQAIESSDNIFFARVALELGSKKFEKGMKKLGVGEDI-------PSDYPFYNAQ  477

Query  955   -SGSKPDGTAMDA---IGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSAGNVIST  1122
              S    D   + A    GQ +    P+Q+  + +A+ NNG++  P+L+           T
Sbjct  478   ISNKNLDNEILLADSGYGQGEILINPVQILSIYSALENNGNINAPHLLK---------DT  528

Query  1123  HTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQHGQDNSGLPFA  1302
               +      +S      L   M+ VV      +       + GK+GTA+      G    
Sbjct  529   KNKVWKKNIISKENINLLTDGMQQVVNKTHKEDIYRSYANLIGKSGTAELKM-KQGRQIG  587

Query  1303  WFVSYAKGQDGKQVAVAVVVED  1368
             WF+SY K  D   + +A+ V+D
Sbjct  588   WFISYDK--DNPNMMMAINVKD  607


&gt;1MWS_A Chain A, Structure Of Nitrocefin Acyl-Penicillin Binding Protein 
2a From Methicillin Resistant Staphylococcus Aureus Strain 
27r At 2.00 A Resolution.
 1MWS_B Chain B, Structure Of Nitrocefin Acyl-Penicillin Binding Protein 
2a From Methicillin Resistant Staphylococcus Aureus Strain 
27r At 2.00 A Resolution.
 1MWT_A Chain A, Structure Of Penicillin G Acyl-Penicillin Binding Protein 
2a From Methicillin Resistant Staphylococcus Aureus Strain 
27r At 2.45 A Resolution.
 1MWT_B Chain B, Structure Of Penicillin G Acyl-Penicillin Binding Protein 
2a From Methicillin Resistant Staphylococcus Aureus Strain 
27r At 2.45 A Resolution.
Length=646

 Score = 112 bits (280),  Expect = 5e-26, Method: Compositional matrix adjust.
 Identities = 106/384 (28%), Positives = 164/384 (43%), Gaps = 59/384 (15%)
 Frame = +1

Query  301   LEKLEDGILSGTDSRLFFRNTL----------DMLTGKPKQGGDVVTTIDPKVQKAGFEG  450
             LEKL D  L   D    +R T+           ++  K K G D+  TID KVQK+ +  
Sbjct  261   LEKLYDKKLQHEDG---YRVTIVDDNSNTIAHTLIEKKKKDGKDIQLTIDAKVQKSIYNN  317

Query  451   LGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALR  630
             + N  G+  AI P+TG +L LVSTPSYD   F  G  ++E  +  L  D  +P+LN+  +
Sbjct  318   MKNDYGSGTAIHPQTGELLALVSTPSYDVYPFMYGMSNEE--YNKLTEDKKEPLLNK-FQ  374

Query  631   ETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPG------TSTPLINASPTEDC  792
              T  PG T K++TA            +   D    Y + G       S    N +  E  
Sbjct  375   ITTSPGXTQKILTAMIGLN-------NKTLDDKTSYKIDGKGWQKDKSWGGYNVTRYEVV  427

Query  793   -GNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFP-----  954
              GN  ++ A++ S N  F ++  ELG  K     +K G  +++        S +P     
Sbjct  428   NGNIDLKQAIESSDNIFFARVALELGSKKFEKGMKKLGVGEDI-------PSDYPFYNAQ  480

Query  955   -SGSKPDGTAMDA---IGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSAGNVIST  1122
              S    D   + A    GQ +    P+Q+  + +A+ NNG++  P+L+           T
Sbjct  481   ISNKNLDNEILLADSGYGQGEILINPVQILSIYSALENNGNINAPHLLK---------DT  531

Query  1123  HTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ--HGQDNSGLP  1296
               +      +S      L   M+ VV      +       + GK+GTA+    Q  +G  
Sbjct  532   KNKVWKKNIISKENINLLTDGMQQVVNKTHKEDIYRSYANLIGKSGTAELKMKQGETGRQ  591

Query  1297  FAWFVSYAKGQDGKQVAVAVVVED  1368
               WF+SY K  D   + +A+ V+D
Sbjct  592   IGWFISYDK--DNPNMMMAINVKD  613


&gt;1MWR_A Chain A, Structure Of Semet Penicillin Binding Protein 2a From 
Methicillin Resistant Staphylococcus Aureus Strain 27r (Trigonal 
Form) At 2.45 A Resolution.
 1MWR_B Chain B, Structure Of Semet Penicillin Binding Protein 2a From 
Methicillin Resistant Staphylococcus Aureus Strain 27r (Trigonal 
Form) At 2.45 A Resolution.
Length=646

 Score = 108 bits (271),  Expect = 7e-25, Method: Compositional matrix adjust.
 Identities = 105/387 (27%), Positives = 165/387 (43%), Gaps = 71/387 (18%)
 Frame = +1

Query  301   LEKLEDGILSGTDSRLFFRNTL----------DMLTGKPKQGGDVVTTIDPKVQKAGFEG  450
             LEKL D  L   D    +R T+           ++  K K G D+  TID KVQK+ +  
Sbjct  261   LEKLYDKKLQHEDG---YRVTIVDDNSNTIAHTLIEKKKKDGKDIQLTIDAKVQKSIYNN  317

Query  451   LGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALR  630
               N  G+  AI P+TG +L LVSTPSYD   F  G  ++E  +  L  D  +P+LN+  +
Sbjct  318   XKNDYGSGTAIHPQTGELLALVSTPSYDVYPFXYGXSNEE--YNKLTEDKKEPLLNK-FQ  374

Query  631   ETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPG------TSTPLINASPTEDC  792
              T  PGST K++TA            +   D    Y + G       S    N +  E  
Sbjct  375   ITTSPGSTQKILTAXIGLN-------NKTLDDKTSYKIDGKGWQKDKSWGGYNVTRYEVV  427

Query  793   -GNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFP-----  954
              GN  ++ A++ S N  F ++  ELG  K     +K G  +++        S +P     
Sbjct  428   NGNIDLKQAIESSDNIFFARVALELGSKKFEKGXKKLGVGEDI-------PSDYPFYNAQ  480

Query  955   -SGSKPDGTAMDA---IGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGS---AGNV  1113
              S    D   + A    GQ +    P+Q+  + +A+ NNG++  P+L+    +     N+
Sbjct  481   ISNKNLDNEILLADSGYGQGEILINPVQILSIYSALENNGNINAPHLLKDTKNKVWKKNI  540

Query  1114  ISTHTEHQLS----QAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ--HG  1275
             IS    + L+    Q V+    + + +   +++                GK+GTA+    
Sbjct  541   ISKENINLLTDGXQQVVNKTHKEDIYRSYANLI----------------GKSGTAELKXK  584

Query  1276  QDNSGLPFAWFVSYAKGQDGKQVAVAV  1356
             Q  +G    WF+SY K       A+ V
Sbjct  585   QGETGRQIGWFISYDKDNPNXXXAINV  611


&gt;3UE3_A Chain A, Crystal Structure Of Acinetobacter Baumanni Pbp3
Length=554

 Score = 93.2 bits (230),  Expect = 8e-20, Method: Compositional matrix adjust.
 Identities = 104/372 (28%), Positives = 163/372 (44%), Gaps = 55/372 (15%)
 Frame = +1

Query  388   KQGGDVVTTIDPKVQKAGFE-----GLGN--KKGAAVAIDPKTGAILGLVSTPSYDPGTF  546
             + G ++  +ID ++Q   +      G+ N  +   A+A+D KTG IL + S PSY+P   
Sbjct  200   ESGENITLSIDSRLQYIMYRELTAAGVANNARSATAIAVDVKTGEILAMTSWPSYNPNDK  259

Query  547   AGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDT  726
              G +  D              M NR   + + PGST K  T A A E+G+Y +P+ + +T
Sbjct  260   GGLSNKDA-------------MRNRGAIDMFEPGSTMKPFTVAAALESGQY-TPNSIVNT  305

Query  727   PDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGF  906
                 +  G  T       T + G  T+   +  S N    K+   L  + L +   + GF
Sbjct  306   APGTMRLGWHT----IRDTHNYGALTLTGIIVKSSNVGSAKLALSLPKEALPSFFRRAGF  361

Query  907   NKEVTIPIRAD-ASHFPSGSKPDGTAMDAIGQ-HDTRATPLQMAMVAAAIANNGSLMEPY  1080
              +   +    + A    S  K + + +  +   +   AT LQ+A   A +AN+G  M   
Sbjct  362   GQSSDVKFPGESAGLLYSADKLNSSQLGTMAYGYGLNATILQLAQGYAMLANHGVEMP--  419

Query  1081  LVAQEGSAGNVISTHTEHQL---SQAVSPATAQKLQQLMESV-VQHGTGTNAKIPGVTVG  1248
                        +S H   Q+    Q + P  A ++  ++E V +  GT   A IPG  VG
Sbjct  420   -----------LSLHKLDQVPEGRQVLDPKIADQVLMMLEQVTLPGGTAKQAVIPGYRVG  468

Query  1249  GKTGTA------QHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLA  1410
             GKTGTA      + G  NS    A F   A   D + +A+ VVVE+      +  GG +A
Sbjct  469   GKTGTAHKLRADRKGYSNSEY-RALFAGVAPVSDPR-LAMIVVVENPQG---RYYGGLVA  523

Query  1411  APIAKAMMQAAL  1446
             AP+   +MQ +L
Sbjct  524   APVFAKIMQESL  535


&gt;5TRO_A Chain A, 1.8 Angstrom Resolution Crystal Structure Of Dimerization 
And Transpeptidase Domains (residues 39-608) Of Penicillin-binding 
Protein 1 From Staphylococcus Aureus.
 5TRO_B Chain B, 1.8 Angstrom Resolution Crystal Structure Of Dimerization 
And Transpeptidase Domains (residues 39-608) Of Penicillin-binding 
Protein 1 From Staphylococcus Aureus.
Length=573

 Score = 91.7 bits (226),  Expect = 3e-19, Method: Compositional matrix adjust.
 Identities = 117/438 (27%), Positives = 178/438 (41%), Gaps = 67/438 (15%)
 Frame = +1

Query  226   KRSWVDGPMYAPVTGYSSQTYDASQL------EKLEDGILSGTDSRLFFRNTL-------  366
             +R + +G   + + G + +  D  +L      EK+ D  LSG+   L + + +       
Sbjct  133   ERFYPNGNFASHLIGRAQKNPDTGELKGALGVEKIFDSYLSGSKGSLRYIHDIWGYIAPN  192

Query  367   DMLTGKPKQGGDVVTTIDPKVQKAGFEGLGN-------KKGAAVAIDPKTGAILGLVSTP  525
                  +PK+G DV  TID  +Q    E L         K   AV  D KTG IL     P
Sbjct  193   TKKEKQPKRGDDVHLTIDSNIQVFVEEALDGXVERYQPKDLFAVVXDAKTGEILAYSQRP  252

Query  526   SYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQS  705
             +++P T     KD  K W            N   + TY PGSTFK    A A + G +  
Sbjct  253   TFNPET----GKDFGKKWA-----------NDLYQNTYEPGSTFKSYGLAAAIQEGAFD-  296

Query  706   PSDVTDTPDQYILPGTSTPLINASPTED-----CGNATVQHAMDLSCNTVFGKMGAELGG  870
                    PD+    G     I  S   D      G          S NT+   +   +G 
Sbjct  297   -------PDKKYKSGHRD--IXGSRISDWNRVGWGEIPXSLGFTYSSNTLXXHLQDLVGA  347

Query  871   DKLRAQAEKFGFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAI  1050
             DK ++  E+FGF K        +A      S        + GQ  T  TP+Q     +A 
Sbjct  348   DKXKSWYERFGFGKSTKGXFDGEAPGQIGWSNELQQKTSSFGQ-STTVTPVQXLQAQSAF  406

Query  1051  ANNGSLMEPYLVAQEGSAGNVISTHT----EHQLS-QAVSPATAQKLQQLMESVV--QHG  1209
              N+G+ ++P+ V    S  N +S       + Q++ + ++  TA+K+++ ++ VV  +  
Sbjct  407   FNDGNXLKPWFV---NSVENPVSKRQFYKGQKQIAGKPITKDTAEKVEKQLDLVVNSKKS  463

Query  1210  TGTNAKIPGVTVGGKTGTAQHGQDNSG----LPFAWFVSYAKGQDGKQVAVAVVVEDGSS  1377
                N +I G  V GKTGTAQ    N G     P  +FVS+    D  +    V+V  G S
Sbjct  464   HAANYRIDGYEVEGKTGTAQVAAPNGGGYVKGPNPYFVSFX--GDAPKKNPKVIVYAGXS  521

Query  1378  EAQQISGGSLAAPIAKAM  1431
              AQ+    +    ++KA 
Sbjct  522   LAQKNDQEAYELGVSKAF  539


&gt;5UY7_A Chain A, Crystal Structure Of A Peptidoglycan Glycosyltransferase 
From Burkholderia Ambifaria
Length=579

 Score = 90.9 bits (224),  Expect = 5e-19, Method: Compositional matrix adjust.
 Identities = 116/443 (26%), Positives = 192/443 (43%), Gaps = 74/443 (17%)
 Frame = +1

Query  214   RYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLED-GILSGTDS-RLFFRNTLDMLTGK-  384
             R +YKR + +G + A + G+++   +  +  +L D  +LSGT   R   ++ L  +    
Sbjct  124   RNEYKRFYPEGEITAHLIGFTNVEDEGQEGVELGDQKLLSGTSGVRRVIKDRLGHIVEDV  183

Query  385   -----PKQGGDVVTTIDPKVQ-------KAGFEGLGNKKGAAVAIDPKTGAILGLVSTPS  528
                  P  G DV  +ID K+Q       KA  E    K GAA+ +D +TG +L LV+ P+
Sbjct  184   AEQVPPHNGTDVGLSIDSKIQYIAYANLKAAVEKFKAKAGAAMVVDVRTGEVLALVNYPT  243

Query  529   YDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSP  708
             Y+P        +D    T       + + NR L + + PGS  K  T + A +  +    
Sbjct  244   YNP--------NDRTRLTG------EQLRNRILTDVFEPGSIMKPFTVSLALDLHRV---  286

Query  709   SDVTDTPDQYILPGTSTPLINASPTED---CGNATVQHAMDLSCNTVFGKMGAELGGDKL  879
                  TP+  +  G    +++ +P  D    G  TV   +  S N    K+   +  +++
Sbjct  287   -----TPNTLVETGNGHFVLDGAPITDDAGFGTLTVGGVIQKSSNIGATKIAMTMRPEEM  341

Query  880   --------RAQAEKFGFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAM  1035
                       QA K GF       +R     + S  + +   M     +    +  Q+A 
Sbjct  342   WNMYTSIGLGQAPKVGFPGAAAGRLRP----WKSWRRIEQATMSY--GYGLSVSLFQLAR  395

Query  1036  VAAAIANNGSLMEPYLVAQEGSAGNVISTHTEHQL--SQAVSPATAQKLQQLMESVVQH-  1206
                AIA++G +M             +  T    Q+  +Q  +P TA++++ ++E+VV   
Sbjct  396   AYTAIAHDGEMMPV----------TIFKTDPNQQITGTQVFTPTTAREVRTMLETVVAPG  445

Query  1207  GTGTNAKIPGVTVGGKTGTA--QHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVED---G  1371
             GT  +A +PG  VGGK+GTA    G   +    A FV  A      ++ VAV V++   G
Sbjct  446   GTSPDAAVPGYRVGGKSGTAYKHEGHGYTRKYRASFVGMAP-MPNPRIVVAVSVDEPTAG  504

Query  1372  SSEAQQISGGSLAAPIAKAMMQA  1440
             S    Q+SG   +A IA   M+A
Sbjct  505   SHFGGQVSGPVFSA-IAGDTMRA  526


&gt;5LP4_A Chain A, Penicillin-Binding Protein (PBP2) from Helicobacter 
pylori
 5LP4_B Chain B, Penicillin-Binding Protein (PBP2) from Helicobacter 
pylori
 5LP5_A Chain A, Complex Between Penicillin-binding Protein (pbp2) And 
Mrec From Helicobacter Pylori
 5LP5_B Chain B, Complex Between Penicillin-binding Protein (pbp2) And 
Mrec From Helicobacter Pylori
Length=594

 Score = 89.0 bits (219),  Expect = 2e-18, Method: Compositional matrix adjust.
 Identities = 80/312 (26%), Positives = 125/312 (40%), Gaps = 35/312 (11%)
 Frame = +1

Query  385   PKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKD  564
             P     +  ++D ++QK   +   NK+GA + +D + G +L   S P Y+   F GG   
Sbjct  225   PSTNNHLQLSLDKRLQKEADKLFENKRGAILVMDAENGELLVAGSYPEYNLNDFVGGISQ  284

Query  565   DEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYIL  744
             D+  W  L  D   P+LNR     YPPGS  K+    +  E       + +   P  +I 
Sbjct  285   DK--WQKLQDDIYNPLLNRFANALYPPGSVVKMGVGLSFLENLHITENTTIPTPP--FIE  340

Query  745   PGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTI  924
              G              GN+ +  A+  S +  F K G E+  +KL     + GF ++  +
Sbjct  341   VGKHK--FRDWKKTGHGNSNLYKAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGV  398

Query  925   PIRAD-----------ASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLM  1071
              +  +              F    +   T + AIGQ    ATPLQ+      IA  G L 
Sbjct  399   DLPNEFVGIVPDNLWKLKRFNQDWRVGDTLITAIGQGSFLATPLQVLAYTGLIA-TGKLA  457

Query  1072  EPYLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQL---MESVVQHGTGT---NAKIP  1233
              P+            + + +  L   ++    +KLQ L   M  V  H  GT   + +  
Sbjct  458   TPHF-----------AINNKQPLKDPLNSFQKKKLQALRVGMYEVCNHKDGTAYHSTRGS  506

Query  1234  GVTVGGKTGTAQ  1269
              +T+  KTGTAQ
Sbjct  507   KITLACKTGTAQ  518


&gt;3EQV_A Chain A, Crystal Structure Of Penicillin-binding Protein 2 From 
Neisseria Gonorrhoeae Containing Four Mutations Associated 
With Penicillin Resistance
 3EQV_B Chain B, Crystal Structure Of Penicillin-binding Protein 2 From 
Neisseria Gonorrhoeae Containing Four Mutations Associated 
With Penicillin Resistance
Length=542

 Score = 87.8 bits (216),  Expect = 5e-18, Method: Compositional matrix adjust.
 Identities = 117/457 (26%), Positives = 191/457 (42%), Gaps = 81/457 (18%)
 Frame = +1

Query  178   QAVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQ-LE-KLEDGILSGTDSRLF  351
             +A+   +FV     + KR +  G ++A V G++       + LE  LED +     + + 
Sbjct  113   KALGLENFV--FEKELKRHYPMGNLFAHVIGFTDIDGKGQEGLELSLEDSLYGEDGAEVV  170

Query  352   FR----NTLDML----TGKPKQGGDVVTTIDPKVQKAGFEGLGN-------KKGAAVAID  486
              R    N +D L       P+ G D++ ++D ++Q   +E L         K G  V +D
Sbjct  171   LRDRQGNIVDSLDSPRNKAPQNGKDIILSLDQRIQTLAYEELNKAVEYHQAKAGTVVVLD  230

Query  487   PKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLV  666
              +TG IL L +TP+YDP     G  D E+              NRA+ +   PGS  K  
Sbjct  231   ARTGEILALANTPAYDPNR--PGRADSEQRR------------NRAVTDMIEPGSAIKPF  276

Query  667   TAATAFETGKYQSPSDVTDTPDQYILPGTSTPLINASPTEDCG---NATVQHAMDLSCNT  837
               A A + GK      +   P +          I  SP  D     +  V+  M  S N 
Sbjct  277   VIAKALDAGKTDLNERLNTQPYK----------IGPSPVRDTHVYPSLDVRGIMQKSSNV  326

Query  838   VFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPSGS----------KPDGTAMD  987
                K+ A  G +      E + F  E+ I +R   S FP  +          +P   A  
Sbjct  327   GTSKLSARFGAE------EMYDFYHELGIGVRMH-SGFPGETAGLLRNWRRWRPIEQATM  379

Query  988   AIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSAGNVISTHTEHQLSQAVSPATA  1167
             + G +  + + LQ+A    A+ ++G L+ P    ++  A          Q  +     TA
Sbjct  380   SFG-YGLQLSLLQLARAYTALTHDGVLL-PLSFEKQAVA---------PQGKRIFKEXTA  428

Query  1168  QKLQQLMESVVQ-HGTGTNAKIPGVTVGGKTGTAQ---HGQDNSGLPFAWFVSYAKGQDG  1335
             ++++ LM SV +  GTGT   + G  VG KTGTA+   +G+         F+ +A  ++ 
Sbjct  429   REVRNLMVSVTEPGGTGTAGAVDGFDVGAKTGTARKLVNGRYVDNKHVGTFIGFAPAKN-  487

Query  1336  KQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAAL  1446
              +V VAV +++ +  A    GG +A    K +M  +L
Sbjct  488   PRVIVAVTIDEPT--AHGYYGGVVAGSPFKKIMGGSL  522


&gt;3EQU_A Chain A, Crystal Structure Of Penicillin-Binding Protein 2 From 
Neisseria Gonorrhoeae
 3EQU_B Chain B, Crystal Structure Of Penicillin-Binding Protein 2 From 
Neisseria Gonorrhoeae
Length=542

 Score = 87.0 bits (214),  Expect = 9e-18, Method: Compositional matrix adjust.
 Identities = 116/457 (25%), Positives = 190/457 (42%), Gaps = 81/457 (18%)
 Frame = +1

Query  178   QAVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQ-LE-KLEDGILSGTDSRLF  351
             +A+   +FV     + KR +  G ++A V G++       + LE  LED +     + + 
Sbjct  113   KALGLENFV--FEKELKRHYPXGNLFAHVIGFTDIDGKGQEGLELSLEDSLYGEDGAEVV  170

Query  352   FR----NTLDML----TGKPKQGGDVVTTIDPKVQKAGFEGLGN-------KKGAAVAID  486
              R    N +D L       P+ G D++ ++D ++Q   +E L         K G  V +D
Sbjct  171   LRDRQGNIVDSLDSPRNKAPQNGKDIILSLDQRIQTLAYEELNKAVEYHQAKAGTVVVLD  230

Query  487   PKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLV  666
              +TG IL L +TP+YDP     G  D E+              NRA+ +   PGS  K  
Sbjct  231   ARTGEILALANTPAYDPNR--PGRADSEQ------------RRNRAVTDXIEPGSAIKPF  276

Query  667   TAATAFETGKYQSPSDVTDTPDQYILPGTSTPLINASPTEDCG---NATVQHAMDLSCNT  837
               A A + GK      +   P +          I  SP  D     +  V+     S N 
Sbjct  277   VIAKALDAGKTDLNERLNTQPYK----------IGPSPVRDTHVYPSLDVRGIXQKSSNV  326

Query  838   VFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPSGS----------KPDGTAMD  987
                K+ A  G +      E + F  E+ I +R   S FP  +          +P   A  
Sbjct  327   GTSKLSARFGAE------EXYDFYHELGIGVRXH-SGFPGETAGLLRNWRRWRPIEQATX  379

Query  988   AIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSAGNVISTHTEHQLSQAVSPATA  1167
             + G +  + + LQ+A    A+ ++G L+ P    ++  A          Q  +     TA
Sbjct  380   SFG-YGLQLSLLQLARAYTALTHDGVLL-PLSFEKQAVA---------PQGKRIFKEXTA  428

Query  1168  QKLQQLMESVVQ-HGTGTNAKIPGVTVGGKTGTAQ---HGQDNSGLPFAWFVSYAKGQDG  1335
             ++++ L  SV +  GTGT   + G  VG KTGTA+   +G+       A F+ +A  ++ 
Sbjct  429   REVRNLXVSVTEPGGTGTAGAVDGFDVGAKTGTARKFVNGRYADNKHVATFIGFAPAKN-  487

Query  1336  KQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAAL  1446
              +V VAV +++ +  A    GG +A P  K +   +L
Sbjct  488   PRVIVAVTIDEPT--AHGYYGGVVAGPPFKKIXGGSL  522


&gt;5KSH_A Chain A, Crystal Structure Of Penicillin-binding Protein 2 From 
Neisseria Gonorrhoeae Containing An A501t Mutation Associated 
With Cephalosporin Resistance
 5KSH_B Chain B, Crystal Structure Of Penicillin-binding Protein 2 From 
Neisseria Gonorrhoeae Containing An A501t Mutation Associated 
With Cephalosporin Resistance
Length=540

 Score = 85.9 bits (211),  Expect = 2e-17, Method: Compositional matrix adjust.
 Identities = 116/457 (25%), Positives = 190/457 (42%), Gaps = 81/457 (18%)
 Frame = +1

Query  178   QAVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQ-LE-KLEDGILSGTDSRLF  351
             +A+   +FV     + KR +  G ++A V G++       + LE  LED +     + + 
Sbjct  111   KALGLENFV--FEKELKRHYPMGNLFAHVIGFTDIDGKGQEGLELSLEDSLYGEDGAEVV  168

Query  352   FR----NTLDML----TGKPKQGGDVVTTIDPKVQKAGFEGLGN-------KKGAAVAID  486
              R    N +D L       P+ G D++ ++D ++Q   +E L         K G  V +D
Sbjct  169   LRDRQGNIVDSLDSPRNKAPQNGKDIILSLDQRIQTLAYEELNKAVEYHQAKAGTVVVLD  228

Query  487   PKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLV  666
              +TG IL L +TP+YDP     G  D E+              NRA+ +   PGS  K  
Sbjct  229   ARTGEILALANTPAYDPNR--PGRADSEQRR------------NRAVTDMIEPGSAIKPF  274

Query  667   TAATAFETGKYQSPSDVTDTPDQYILPGTSTPLINASPTEDCG---NATVQHAMDLSCNT  837
               A A + GK      +   P +          I  SP  D     +  V+  M  S N 
Sbjct  275   VIAKALDAGKTDLNERLNTQPYK----------IGPSPVRDTHVYPSLDVRGIMQKSSNV  324

Query  838   VFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPSGS----------KPDGTAMD  987
                K+ A  G +      E + F  E+ I +R   S FP  +          +P   A  
Sbjct  325   GTSKLSARFGAE------EMYDFYHELGIGVRMH-SGFPGETAGLLRNWRRWRPIEQATM  377

Query  988   AIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSAGNVISTHTEHQLSQAVSPATA  1167
             + G +  + + LQ+A    A+ ++G L+ P    ++  A          Q  +     TA
Sbjct  378   SFG-YGLQLSLLQLARAYTALTHDGVLL-PLSFEKQAVA---------PQGKRIFKEXTA  426

Query  1168  QKLQQLMESVVQ-HGTGTNAKIPGVTVGGKTGTAQ---HGQDNSGLPFAWFVSYAKGQDG  1335
             ++++ LM SV +  GTGT   + G  VG KTGT +   +G+         F+ +A  ++ 
Sbjct  427   REVRNLMVSVTEPGGTGTAGAVDGFDVGAKTGTTRKLVNGRYVDNKHVGTFIGFAPAKN-  485

Query  1336  KQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAAL  1446
              +V VAV +++ +  A    GG +A    K +M  +L
Sbjct  486   PRVIVAVTIDEPT--AHGYYGGVVAGSPFKKIMGGSL  520


&gt;4L0L_A Chain A, Crystal Structure Of P.aeruginosa Pbp3 In Complex With 
Compound 4
Length=537

 Score = 78.2 bits (191),  Expect = 5e-15, Method: Compositional matrix adjust.
 Identities = 96/382 (25%), Positives = 170/382 (45%), Gaps = 64/382 (17%)
 Frame = +1

Query  373   LTGKPKQGGDVVTTIDPKVQKAGFEGLGN-------KKGAAVAIDPKTGAILGLVSTPSY  531
             +T   K G  +  +ID ++Q      L N       K G+ V +D KTG IL + + P+Y
Sbjct  167   VTKNAKPGKTLALSIDLRLQYLAHRELRNALLENGAKAGSLVIMDVKTGEILAMTNQPTY  226

Query  532   DPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPS  711
             +P       ++ + A           M NRA+ + + PGST K  + + A  +G+++ PS
Sbjct  227   NPNN----RRNLQPA----------AMRNRAMIDVFEPGSTVKPFSMSAALASGRWK-PS  271

Query  712   DVTDTPDQYILPGTSTPLINASPTEDCGNATVQHAMDL------SCNTVFGKMGAELGGD  873
             D+ D     + PGT    I      D    + Q  +DL      S N    K+  ++G +
Sbjct  272   DIVD-----VYPGTLQ--IGRYTIRDVSRNSRQ--LDLTGILIKSSNVGISKIAFDIGAE  322

Query  874   KLRAQAEKFGFNKEVTIPIRAD-ASHFPSGSK-PDG-TAMDAIGQHDTRATPLQMAMVAA  1044
              + +  ++ G  ++  +    +   + P+  K P   TA  A G +    T +Q+A   A
Sbjct  323   SIYSVMQQVGLGQDTGLGFPGERVGNLPNHRKWPKAETATLAYG-YGLSVTAIQLAHAYA  381

Query  1045  AIANNGSLMEPYLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGT-N  1221
             A+AN+G  +   +   +     V          Q +SP  A  +Q +++ VV+   G   
Sbjct  382   ALANDGKSVPLSMTRVDRVPDGV----------QVISPEVASTVQGMLQQVVEAQGGVFR  431

Query  1222  AKIPGVTVGGKTGTAQH-------GQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSE  1380
             A++PG    GK+GTA+         ++N+    + F  +A   D  ++A+ VV+++ S  
Sbjct  432   AQVPGYHAAGKSGTARKVSVGTKGYRENAYR--SLFAGFAPATD-PRIAMVVVIDEPSKA  488

Query  1381  AQQISGGSLAAPIAKAMMQAAL  1446
                  GG ++AP+   +M  AL
Sbjct  489   G--YFGGLVSAPVFSKVMAGAL  508


&gt;3PBN_A Chain A, Crystal Structure Of Apo Pbp3 From Pseudomonas Aeruginosa
 3PBO_A Chain A, Crystal Structure Of Pbp3 Complexed With Ceftazidime
 3PBQ_A Chain A, Crystal Structure Of Pbp3 Complexed With Imipenem
 3PBR_A Chain A, Crystal Structure Of Pbp3 Complexed With Meropenem
 3PBS_A Chain A, Crystal Structure Of Pbp3 Complexed With Aztreonam
 3PBT_A Chain A, Crystal Structure Of Pbp3 Complexed With Mc-1
 4OOL_A Chain A, Crystal Structure Of Pbp3 In Complex With Compound 14 
((2e)-2-({[(2s)- 2-{[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(1,5-dihydroxy-4-oxo-1,4- 
Dihydropyridin-2-yl)methoxy]imino}acetyl]amino}-3- 
Oxopropyl]oxy}imino)pentanedioic Acid)
 4OOM_A Chain A, Crystal Structure Of Pbp3 In Complex With Bal30072 ((2z)-2-(2-amino-1, 
3-thiazol-4-yl)-2-{[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl) 
Methoxy]imino}-n-{(2s)-1-hydroxy-3-methyl-3-[(sulfooxy)amino]butan-2- 
Yl}ethanamide)
 4WEJ_A Chain A, Crystal Structure Of Pseudomonas Aeruginosa Pbp3 With 
A R4 Substituted Allyl Monocarbam
 4WEL_A Chain A, Crystal Structure Of Pseudomonas Aeruginosa Pbp3 With 
Smc-3176
Length=538

 Score = 77.8 bits (190),  Expect = 7e-15, Method: Compositional matrix adjust.
 Identities = 96/382 (25%), Positives = 170/382 (45%), Gaps = 64/382 (17%)
 Frame = +1

Query  373   LTGKPKQGGDVVTTIDPKVQKAGFEGLGN-------KKGAAVAIDPKTGAILGLVSTPSY  531
             +T   K G  +  +ID ++Q      L N       K G+ V +D KTG IL + + P+Y
Sbjct  168   VTKNAKPGKTLALSIDLRLQYLAHRELRNALLENGAKAGSLVIMDVKTGEILAMTNQPTY  227

Query  532   DPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPS  711
             +P       ++ + A           M NRA+ + + PGST K  + + A  +G+++ PS
Sbjct  228   NPNN----RRNLQPA----------AMRNRAMIDVFEPGSTVKPFSMSAALASGRWK-PS  272

Query  712   DVTDTPDQYILPGTSTPLINASPTEDCGNATVQHAMDL------SCNTVFGKMGAELGGD  873
             D+ D     + PGT    I      D    + Q  +DL      S N    K+  ++G +
Sbjct  273   DIVD-----VYPGTLQ--IGRYTIRDVSRNSRQ--LDLTGILIKSSNVGISKIAFDIGAE  323

Query  874   KLRAQAEKFGFNKEVTIPIRAD-ASHFPSGSK-PDG-TAMDAIGQHDTRATPLQMAMVAA  1044
              + +  ++ G  ++  +    +   + P+  K P   TA  A G +    T +Q+A   A
Sbjct  324   SIYSVMQQVGLGQDTGLGFPGERVGNLPNHRKWPKAETATLAYG-YGLSVTAIQLAHAYA  382

Query  1045  AIANNGSLMEPYLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGT-N  1221
             A+AN+G  +   +   +     V          Q +SP  A  +Q +++ VV+   G   
Sbjct  383   ALANDGKSVPLSMTRVDRVPDGV----------QVISPEVASTVQGMLQQVVEAQGGVFR  432

Query  1222  AKIPGVTVGGKTGTAQH-------GQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSE  1380
             A++PG    GK+GTA+         ++N+    + F  +A   D  ++A+ VV+++ S  
Sbjct  433   AQVPGYHAAGKSGTARKVSVGTKGYRENAYR--SLFAGFAPATD-PRIAMVVVIDEPSKA  489

Query  1381  AQQISGGSLAAPIAKAMMQAAL  1446
                  GG ++AP+   +M  AL
Sbjct  490   G--YFGGLVSAPVFSKVMAGAL  509


&gt;4BJP_A Chain A, Crystal Structure Of E. Coli Penicillin Binding Protein 
3
Length=511

 Score = 77.8 bits (190),  Expect = 7e-15, Method: Compositional matrix adjust.
 Identities = 102/440 (23%), Positives = 177/440 (40%), Gaps = 70/440 (16%)
 Frame = +1

Query  211   LRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLE---DGILSGTDSRLFFRN------T  363
             LR + +R +  G + A + G+++   D+  +E +E   D  L+G       R        
Sbjct  95    LREESRRYYPSGEVTAHLIGFTN--VDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVI  152

Query  364   LDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGN-------KKGAAVAIDPKTGAILGLVST  522
              D+ +   +   ++  +ID ++Q   +  L N       + G+AV +D  TG +L + ++
Sbjct  153   EDISSTDSQAAHNLALSIDERLQALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANS  212

Query  523   PSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQ  702
             PSY+P   +G               P + M NR + + + PGST K +   TA + G  +
Sbjct  213   PSYNPNNLSG--------------TPKEAMRNRTITDVFEPGSTVKPMVVMTALQRGVVR  258

Query  703   SPSDVTDTPDQYILPGTSTPLINASPTEDCGN---ATVQHAMDLSCNTVFGKMGAELGGD  873
               S +   P +          IN    +D       T+   +  S N    K+   +   
Sbjct  259   ENSVLNTIPYR----------INGHEIKDVARYSELTLTGVLQKSSNVGVSKLALAMPSS  308

Query  874   KLRAQAEKFGFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQ------HDTRATPLQMAM  1035
              L     +FG  K   + +  +     SG  P       I +      +    TPLQ+A 
Sbjct  309   ALVDTYSRFGLGKATNLGLVGER----SGLYPQKQRWSDIERATFSFGYGLMVTPLQLAR  364

Query  1036  VAAAIANNGSLMEPYLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESV-VQHGT  1212
             V A I + G +  P  + +            E    +++     + +  +MESV +  G 
Sbjct  365   VYATIGSYG-IYRPLSITKVDP-----PVPGERVFPESI----VRTVVHMMESVALPGGG  414

Query  1213  GTNAKIPGVTVGGKTGTAQH-GQDNSGLPFAWFVSYAKG-QDGKQVAVAVVVEDGSSEAQ  1386
             G  A I G  +  KTGTA+  G D  G     +++Y  G     Q   A+VV     +A 
Sbjct  415   GVKAAIKGYRIAIKTGTAKKVGPD--GRYINKYIAYTAGVAPASQPRFALVVVINDPQAG  472

Query  1387  QISGGSLAAPIAKAMMQAAL  1446
             +  GG+++AP+  A+M   L
Sbjct  473   KYYGGAVSAPVFGAIMGGVL  492


&gt;4FSF_A Chain A, Crystal Structure Of Pseudomonas Aeruginosa Pbp3 Complexed 
With Compound 14
Length=536

 Score = 77.8 bits (190),  Expect = 7e-15, Method: Compositional matrix adjust.
 Identities = 96/382 (25%), Positives = 170/382 (45%), Gaps = 64/382 (17%)
 Frame = +1

Query  373   LTGKPKQGGDVVTTIDPKVQKAGFEGLGN-------KKGAAVAIDPKTGAILGLVSTPSY  531
             +T   K G  +  +ID ++Q      L N       K G+ V +D KTG IL + + P+Y
Sbjct  166   VTKNAKPGKTLALSIDLRLQYLAHRELRNALLENGAKAGSLVIMDVKTGEILAMTNQPTY  225

Query  532   DPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPS  711
             +P       ++ + A           M NRA+ + + PGST K  + + A  +G+++ PS
Sbjct  226   NPNN----RRNLQPA----------AMRNRAMIDVFEPGSTVKPFSMSAALASGRWK-PS  270

Query  712   DVTDTPDQYILPGTSTPLINASPTEDCGNATVQHAMDL------SCNTVFGKMGAELGGD  873
             D+ D     + PGT    I      D    + Q  +DL      S N    K+  ++G +
Sbjct  271   DIVD-----VYPGTLQ--IGRYTIRDVSRNSRQ--LDLTGILIKSSNVGISKIAFDIGAE  321

Query  874   KLRAQAEKFGFNKEVTIPIRAD-ASHFPSGSK-PDG-TAMDAIGQHDTRATPLQMAMVAA  1044
              + +  ++ G  ++  +    +   + P+  K P   TA  A G +    T +Q+A   A
Sbjct  322   SIYSVMQQVGLGQDTGLGFPGERVGNLPNHRKWPKAETATLAYG-YGLSVTAIQLAHAYA  380

Query  1045  AIANNGSLMEPYLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGT-N  1221
             A+AN+G  +   +   +     V          Q +SP  A  +Q +++ VV+   G   
Sbjct  381   ALANDGKSVPLSMTRVDRVPDGV----------QVISPEVASTVQGMLQQVVEAQGGVFR  430

Query  1222  AKIPGVTVGGKTGTAQH-------GQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSE  1380
             A++PG    GK+GTA+         ++N+    + F  +A   D  ++A+ VV+++ S  
Sbjct  431   AQVPGYHAAGKSGTARKVSVGTKGYRENAYR--SLFAGFAPATD-PRIAMVVVIDEPSKA  487

Query  1381  AQQISGGSLAAPIAKAMMQAAL  1446
                  GG ++AP+   +M  AL
Sbjct  488   G--YFGGLVSAPVFSKVMAGAL  507


&gt;4WEK_A Chain A, Crystal Structure Of Pseudomonas Aeruginosa Pbp3 With 
A R4 Substituted Vinyl Monocarbam
Length=538

 Score = 77.8 bits (190),  Expect = 7e-15, Method: Compositional matrix adjust.
 Identities = 96/382 (25%), Positives = 170/382 (45%), Gaps = 64/382 (17%)
 Frame = +1

Query  373   LTGKPKQGGDVVTTIDPKVQKAGFEGLGN-------KKGAAVAIDPKTGAILGLVSTPSY  531
             +T   K G  +  +ID ++Q      L N       K G+ V +D KTG IL + + P+Y
Sbjct  168   VTKNAKPGKTLALSIDLRLQYLAHRELRNALLENGAKAGSLVIMDVKTGEILAMTNQPTY  227

Query  532   DPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPS  711
             +P       ++ + A           M NRA+ + + PGST K  + + A  +G+++ PS
Sbjct  228   NPNN----RRNLQPA----------AMRNRAMIDVFEPGSTVKPFSMSAALASGRWK-PS  272

Query  712   DVTDTPDQYILPGTSTPLINASPTEDCGNATVQHAMDL------SCNTVFGKMGAELGGD  873
             D+ D     + PGT    I      D    + Q  +DL      S N    K+  ++G +
Sbjct  273   DIVD-----VYPGTLQ--IGRYTIRDVSRNSRQ--LDLTGILIKSSNVGISKIAFDIGAE  323

Query  874   KLRAQAEKFGFNKEVTIPIRAD-ASHFPSGSK-PDG-TAMDAIGQHDTRATPLQMAMVAA  1044
              + +  ++ G  ++  +    +   + P+  K P   TA  A G +    T +Q+A   A
Sbjct  324   SIYSVMQQVGLGQDTGLGFPGERVGNLPNHRKWPKAETATLAYG-YGLSVTAIQLAHAYA  382

Query  1045  AIANNGSLMEPYLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGT-N  1221
             A+AN+G  +   +   +     V          Q +SP  A  +Q +++ VV+   G   
Sbjct  383   ALANDGKSVPLSMTRVDRVPDGV----------QVISPEVASTVQGMLQQVVEAQGGVFR  432

Query  1222  AKIPGVTVGGKTGTAQH-------GQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSE  1380
             A++PG    GK+GTA+         ++N+    + F  +A   D  ++A+ VV+++ S  
Sbjct  433   AQVPGYHAAGKSGTARKVSVGTKGYRENAYR--SLFAGFAPATD-PRIAMVVVIDEPSKA  489

Query  1381  AQQISGGSLAAPIAKAMMQAAL  1446
                  GG ++AP+   +M  AL
Sbjct  490   G--YFGGLVSAPVFSKVMAGAL  509


&gt;3OC2_A Chain A, Crystal Structure Of Penicillin-binding Protein 3 From 
Pseudomonas Aeruginosa
 3OCL_A Chain A, Crystal Structure Of Penicillin-binding Protein 3 From 
Pseudomonas Aeruginosa In Complex With Carbenicillin
 3OCN_A Chain A, Crystal Structure Of Penicillin-binding Protein 3 From 
Pseudomonas Aeruginosa In Complex With Ceftazidime
 4KQO_A Chain A, Crystal Structure Of Penicillin-binding Protein 3 From 
Pseudomonas Aeruginosa In Complex With Piperacillin
 4KQO_B Chain B, Crystal Structure Of Penicillin-binding Protein 3 From 
Pseudomonas Aeruginosa In Complex With Piperacillin
 4KQQ_A Chain A, Crystal Structure Of Penicillin-binding Protein 3 From 
Pseudomonas Aeruginosa In Complex With (5s)-penicilloic Acid
 4KQQ_B Chain B, Crystal Structure Of Penicillin-binding Protein 3 From 
Pseudomonas Aeruginosa In Complex With (5s)-penicilloic Acid
 4KQR_A Chain A, Crystal Structure Of Penicillin-binding Protein 3 From 
Pseudomonas Aeruginosa In Complex With (5s)-penicilloic Acid
 4KQR_B Chain B, Crystal Structure Of Penicillin-binding Protein 3 From 
Pseudomonas Aeruginosa In Complex With (5s)-penicilloic Acid
 5DF7_A Chain A, Crystal Structure Of Penicillin-binding Protein 3 From 
Pseudomonas Aeruginosa In Complex With Azlocillin
 5DF7_B Chain B, Crystal Structure Of Penicillin-binding Protein 3 From 
Pseudomonas Aeruginosa In Complex With Azlocillin
 5DF8_A Chain A, Crystal Structure Of Penicillin-binding Protein 3 From 
Pseudomonas Aeruginosa In Complex With Cefoperazone
 5DF8_B Chain B, Crystal Structure Of Penicillin-binding Protein 3 From 
Pseudomonas Aeruginosa In Complex With Cefoperazone
 5DF9_A Chain A, Crystal Structure Of Penicillin-binding Protein 3 In 
Complex With Deacylated Product Of Cefoperazone
Length=564

 Score = 77.8 bits (190),  Expect = 9e-15, Method: Compositional matrix adjust.
 Identities = 96/382 (25%), Positives = 170/382 (45%), Gaps = 64/382 (17%)
 Frame = +1

Query  373   LTGKPKQGGDVVTTIDPKVQKAGFEGLGN-------KKGAAVAIDPKTGAILGLVSTPSY  531
             +T   K G  +  +ID ++Q      L N       K G+ V +D KTG IL + + P+Y
Sbjct  194   VTKNAKPGKTLALSIDLRLQYLAHRELRNALLENGAKAGSLVIMDVKTGEILAMTNQPTY  253

Query  532   DPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPS  711
             +P       ++ + A           M NRA+ + + PGST K  + + A  +G+++ PS
Sbjct  254   NPNN----RRNLQPA----------AMRNRAMIDVFEPGSTVKPFSMSAALASGRWK-PS  298

Query  712   DVTDTPDQYILPGTSTPLINASPTEDCGNATVQHAMDL------SCNTVFGKMGAELGGD  873
             D+ D     + PGT    I      D    + Q  +DL      S N    K+  ++G +
Sbjct  299   DIVD-----VYPGTLQ--IGRYTIRDVSRNSRQ--LDLTGILIKSSNVGISKIAFDIGAE  349

Query  874   KLRAQAEKFGFNKEVTIPIRAD-ASHFPSGSK-PDG-TAMDAIGQHDTRATPLQMAMVAA  1044
              + +  ++ G  ++  +    +   + P+  K P   TA  A G +    T +Q+A   A
Sbjct  350   SIYSVMQQVGLGQDTGLGFPGERVGNLPNHRKWPKAETATLAYG-YGLSVTAIQLAHAYA  408

Query  1045  AIANNGSLMEPYLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGT-N  1221
             A+AN+G  +   +   +     V          Q +SP  A  +Q +++ VV+   G   
Sbjct  409   ALANDGKSVPLSMTRVDRVPDGV----------QVISPEVASTVQGMLQQVVEAQGGVFR  458

Query  1222  AKIPGVTVGGKTGTAQH-------GQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSE  1380
             A++PG    GK+GTA+         ++N+    + F  +A   D  ++A+ VV+++ S  
Sbjct  459   AQVPGYHAAGKSGTARKVSVGTKGYRENAYR--SLFAGFAPATD-PRIAMVVVIDEPSKA  515

Query  1381  AQQISGGSLAAPIAKAMMQAAL  1446
                  GG ++AP+   +M  AL
Sbjct  516   G--YFGGLVSAPVFSKVMAGAL  535


&gt;4ZTK_A Chain A, Transpeptidase Domain Of Ftsi4 D,d-transpeptidase From 
Legionella Pneumophila.
Length=316

 Score = 64.3 bits (155),  Expect = 6e-11, Method: Compositional matrix adjust.
 Identities = 77/295 (26%), Positives = 126/295 (43%), Gaps = 53/295 (18%)
 Frame = +1

Query  589   DSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTSTPLI  768
             +S  NK + +   R  + PGST K   AA A  +G   S +   D    Y + G +    
Sbjct  61    ESSKNKGLESWKSR-IFSPGSTIKPFIAAAAINSGN-SSETKNYDCHSPYYIAGKTFTNY  118

Query  769   NASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASH  948
             N+    +  +A++  A+  S N    ++  E G   +R +  +FGF          D + 
Sbjct  119   NS----NVESASLADAIAKSINVCLIRVSQEAGVPVIRKKLTEFGF----------DXNS  164

Query  949   FPSGSKPDGT--AMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPY-LVAQEGSA---GN  1110
             +    + D    A  A+G++     P+ +           SL++ Y ++A +G +   GN
Sbjct  165   WWQADQSDDLQLAXAALGEN----IPVTIE----------SLIKSYAILANKGHSFDRGN  210

Query  1111  VISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQHGQDNSG  1290
                       S  +S  +   +   +E+ V +GTG  A IPGV+V GKTGT     D   
Sbjct  211   ----------SAIISETSTNSINHXLENAVTNGTGKLAVIPGVSVAGKTGTVIENNDKYL  260

Query  1291  LPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQ---QISGGSLAAPIAKAMMQAAL  1446
               FA +V      D  +  + VV+E+G         +SGG LAAP+ + +   AL
Sbjct  261   ALFAGYVP----ADNPRYVLLVVIEEGYFSKNGKTLVSGGELAAPVFRNVAXDAL  311


&gt;4OVD_A Chain A, Crystal structure of a putative peptidoglycan glycosyltransferase 
from Atopobium parvulum DSM 20469
Length=564

 Score = 65.5 bits (158),  Expect = 7e-11, Method: Compositional matrix adjust.
 Identities = 102/396 (26%), Positives = 160/396 (40%), Gaps = 71/396 (18%)
 Frame = +1

Query  199   FVNGLRYKYKRSWVDGPMYAPVTGY-SSQTYDASQLEKLEDGILSGTDSRLFFRNTLDML  375
             FVN      KR +  G +   + G+ ++    AS LE   + IL+GT+            
Sbjct  146   FVNNT----KRVYPYGNVGVQILGFVNADNEGASGLEYYYNDILAGTNGHXIVETGAG--  199

Query  376   TGKPKQGG-----------DVVTTIDPKVQKAGFEGL--------GNKKGAAVAIDPKTG  498
              G P  GG           D+V +ID ++QK   E L          + G+  A +P+TG
Sbjct  200   -GTPIAGGTSNITEAQNGQDIVLSIDIELQKKAEEQLTAAVKDFEAKQGGSIXAXNPRTG  258

Query  499   AILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLN-RALRETYPPGSTFKLVTAA  675
              I    S P  D  +               D+  +   LN + +   Y PGS FK++T +
Sbjct  259   EIYAAASYPLPDFES---------------DNGVDYESLNLKLVSSIYEPGSVFKVITTS  303

Query  676   TAFETGKYQSPSDVTDTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMG  855
                +   +  P+   + P +  L      + +        + +V+  +  S N     + 
Sbjct  304   IGVDNNLF-GPNSTFNIPTE--LQVGDNKVTDDDWRTSAXDXSVREXLRRSSNVGXAFLE  360

Query  856   AELGGDKLRAQA-EKFG--------FNKEVTIPIRA-DASHFPSGSKPDGTAMDAIGQHD  1005
              +L GDK  A+  +KFG        F  E T  +R+ D    P+G         A GQ  
Sbjct  361   TQLIGDKRFAEGIDKFGIGHTTGIDFPGEATGIVRSLDQYEGPTGGNX------AFGQG-  413

Query  1006  TRATP-LQMAMVAAAIANNGSLMEPYLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQ  1182
               A P +Q+     A+AN G+ + P+    +G  G  +S  T+      +S +TA     
Sbjct  414   -LAIPFIQVIRAYTAVANKGTXVTPHFXVSKG--GQEVSWPTK----DVISSSTASAELD  466

Query  1183  LMESVVQHGTGTNAKIPGVTVGGKTGTAQHGQDNSG  1290
                +VV+ GTG  A I G TV GKTGT Q   + +G
Sbjct  467   XXTTVVKEGTGVRAGIYGYTVAGKTGTGQQVVEETG  502


&gt;4U3T_A Chain A, Crystal Structure Of The Transpeptidase Domain Of Neisseria 
Gonorrhoeae Penicillin-binding Protein 2 Derived From 
The Penicillin- Resistant Strain 6140
 4U3T_B Chain B, Crystal Structure Of The Transpeptidase Domain Of Neisseria 
Gonorrhoeae Penicillin-binding Protein 2 Derived From 
The Penicillin- Resistant Strain 6140
Length=330

 Score = 60.1 bits (144),  Expect = 2e-09, Method: Compositional matrix adjust.
 Identities = 91/374 (24%), Positives = 146/374 (39%), Gaps = 92/374 (25%)
 Frame = +1

Query  412   TIDPKVQKAGFEGLGN-------KKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDE  570
             ++D ++Q   +E L         K G  V +D +TG IL L +TP               
Sbjct  7     SLDQRIQTLAYEELNKAVEYHQAKAGTVVVLDARTGEILALANTPGR-------------  53

Query  571   KAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPG  750
                            NRA+ +   PGS  K    A A + GK      +   P +     
Sbjct  54    ---------------NRAVTDMIEPGSAIKPFVIAKALDAGKTDLNERLNTQPYK-----  93

Query  751   TSTPLINASPTEDCGNAT----VQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEV  918
                  I  SP  D  +      V+  M  S N    K+ A  G +      E + F  E+
Sbjct  94    -----IGPSPVRDDTHVYPSLDVRGIMQKSSNVGTSKLSARFGAE------EMYDFYHEL  142

Query  919   TIPIRADASHFPSGS----------KPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSL  1068
              I +R   S FP  +          +P   A  + G +  + + LQ+A    A+ ++G L
Sbjct  143   GIGVRMH-SGFPGETAGLLRNWRRWRPIEQATMSFG-YGLQLSLLQLARAYTALTHDGVL  200

Query  1069  M----EPYLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQ-HGTGTNAKIP  1233
             +    E   VA +G               +    +TA++++ LM SV +  GTGT   + 
Sbjct  201   LPLSFEKQAVAPQGK--------------RIFKESTAREVRNLMVSVTEPGGTGTAGAVD  246

Query  1234  GVTVGGKTGTAQ---HGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGS  1404
             G  VG KTGTA+   +G+         F+ +A  ++  +V VAV +++ +  A    GG 
Sbjct  247   GFDVGAKTGTARKLVNGRYVDNKHVGTFIGFAPAKN-PRVIVAVTIDEPT--AHGYYGGV  303

Query  1405  LAAPIAKAMMQAAL  1446
             +A    K +M  +L
Sbjct  304   VAGSPFKKIMGGSL  317


&gt;3ZG8_B Chain B, Crystal Structure Of Penicillin Binding Protein 4 From 
Listeria Monocytogenes In The Ampicillin Bound Form
 3ZGA_B Chain B, Crystal Structure Of Peniscillin-binding Protein 4 From 
Listeria Monocytogenes In The Carbenicillin Bound Form
 3ZG9_B Chain B, Crystal Structure Of Penicillin-binding Protein 4 From 
Listeria Monocytogenes In The Cefuroxime Bound Form
Length=537

 Score = 60.5 bits (145),  Expect = 2e-09, Method: Compositional matrix adjust.
 Identities = 79/285 (28%), Positives = 116/285 (41%), Gaps = 47/285 (16%)
 Frame = +1

Query  472   AVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGS  651
             AV +DP TG I  LV         F G                     NRA +    PGS
Sbjct  180   AVLMDPATGGIRALVG--GRGEHVFRG--------------------FNRATQMKAQPGS  217

Query  652   TFK-LVTAATAFETGKYQSPSDVTDTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLS  828
             T K L     A ++G Y   S + D    Y   G  TP  N       G   +  A+  S
Sbjct  218   TMKPLAVYTPALQSG-YDVDSMLKDEKITY--KGNYTP-TNVGGVY-SGEVPMYKAVANS  272

Query  829   CNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQHDT  1008
              N     +  ++G DK     EKFG    +T+P            + D T   A+G    
Sbjct  273   INAPAVWLLDQIGIDKGVKSVEKFG----ITVP------------EKDRTLGLALGGMSK  316

Query  1009  RATPLQMAMVAAAIANNGSLMEPYLVAQ-EGSAGNVISTHTEHQLSQAVSPATAQKLQQL  1185
              A+P++MA   A  ANNG+  E +++ +    +GN +  +   +  Q +S   + ++  +
Sbjct  317   GASPVEMATAYATFANNGAKPESHIITKIVDPSGNTVYENVP-KTKQIISETVSNEMTSM  375

Query  1186  MESVVQHGTGTNAKIPGVTVGGKTGTAQ-HGQDNSGLPFAWFVSY  1317
             +  V+  GTG +A + G  + GKTG+ Q    D SG    WFV Y
Sbjct  376   LLDVINTGTGQSAAVSGHEMAGKTGSTQVPFDDTSGTKDQWFVGY  420


&gt;2WAF_A Chain A, Penicillin-binding Protein 2b (pbp-2b) From Streptococcus 
Pneumoniae (strain R6)
Length=682

 Score = 58.2 bits (139),  Expect = 1e-08, Method: Compositional matrix adjust.
 Identities = 94/333 (28%), Positives = 140/333 (42%), Gaps = 64/333 (19%)
 Frame = +1

Query  472   AVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGS  651
             AVA++PKTGA+L +             G K D K    L  D    + N      + PGS
Sbjct  345   AVALNPKTGAVLSM------------SGIKHDLKTG-ELTPDSLGTVTN-----VFVPGS  386

Query  652   TFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTSTPLINASPTEDCGN--ATVQHAMDL  825
               K  T ++ +E G       +TD   Q I+   S P IN+  T+  G+   T   A++ 
Sbjct  387   VVKAATISSGWENGVLSGNQTLTD---QSIVFQGSAP-INSWYTQAYGSFPITAVQALEY  442

Query  826   SCNT-----VFGKMG-------------AELGGDKLRAQAEKFGFNKEVTIPIRADASHF  951
             S NT       G MG              E   +KLR+   ++G      I +  +++ F
Sbjct  443   SSNTYMVQTALGLMGQTYQPNMFVGTSNLESAMEKLRSTFGEYGLGTATGIDLPDESTGF  502

Query  952   -PSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVA------QEGSAGN  1110
              P          +A GQ D   TP+Q+A   A IANNG  + P +V        +G  G+
Sbjct  503   VPKEYSFANYITNAFGQFDNY-TPMQLAQYVATIANNGVRVAPRIVEGIYGNNDKGGLGD  561

Query  1111  VISTHTEHQLSQA-VSPATAQKLQQLMESVVQHGTG--------TNAKIPGVTVGGKTGT  1263
             +I      ++++  +S +    L Q    V  HGT         +N  +  V++ GKTGT
Sbjct  562   LIQQLQPTEMNKVNISDSDMSILHQGFYQVA-HGTSGLTTGRAFSNGAL--VSISGKTGT  618

Query  1264  AQ-HGQDNSGLPFAWFVSYAKGQDGKQVAVAVV  1359
             A+ +  D         V+YA   D  Q+AVAVV
Sbjct  619   AESYVADGQQATNTNAVAYAPS-DNPQIAVAVV  650


&gt;2V2F_F Chain F, Crystal Structure Of Pbp1a From Drug-resistant Strain 
5204 From Streptococcus Pneumoniae
Length=390

 Score = 57.8 bits (138),  Expect = 1e-08, Method: Compositional matrix adjust.
 Identities = 71/251 (28%), Positives = 111/251 (44%), Gaps = 35/251 (14%)
 Frame = +1

Query  616   NRALRETYPPGSTFKLVT-AATAFETGKYQSPSD-VTDTPDQYILPGTSTPLINASPTED  789
             N+A+      GS  K +T  A A E G Y S +  V D P  Y  PGTSTP+ N      
Sbjct  96    NQAVETNRDWGSAMKPITDYAPAIEYGVYDSTATMVNDIPYNY--PGTSTPVYNWDRAY-  152

Query  790   CGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPSGSKP  969
              GN T+Q+A+  S N    +   ++G D+ +      G +        A +S+    +K 
Sbjct  153   FGNITLQYALQQSRNVTAVETLNKVGLDRAKTFLNGLGIDYPSMHYANAISSNTTESNKQ  212

Query  970   DGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSAGNVISTHTEHQLS--  1143
              G            A+  +MA   AA AN G   +P  + +      V S  ++ + S  
Sbjct  213   YG------------ASSEKMAAAYAAFANGGIYHKPMYINKV-----VFSDGSKKEFSDV  255

Query  1144  --QAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQHGQD-------NSGL-  1293
               +A+   TA  + ++M++V+ +GTG  A +P +   GKTGT+ +  D       N+G  
Sbjct  256   GTRAMKETTAYMMTEMMKTVLAYGTGRGAYLPWLAQAGKTGTSNYTDDEIEKHIKNTGYV  315

Query  1294  -PFAWFVSYAK  1323
              P   FV Y +
Sbjct  316   APDEMFVGYTR  326


&gt;2C5W_B Chain B, Penicillin-Binding Protein 1a (Pbp-1a) Acyl-Enzyme Complex 
(Cefotaxime) From Streptococcus Pneumoniae
Length=385

 Score = 55.8 bits (133),  Expect = 6e-08, Method: Compositional matrix adjust.
 Identities = 63/226 (28%), Positives = 105/226 (46%), Gaps = 26/226 (12%)
 Frame = +1

Query  613   LNRALRETYPPGSTFKLVT-AATAFETGKYQSPSDVT-DTPDQYILPGTSTPLINASPTE  786
             +N+A+      GST K +T  A A E G Y+S + +  D P  Y  PGT+TP+ N     
Sbjct  93    INQAVETNRDWGSTMKPITDYAPALEYGVYESTATIVHDEPYNY--PGTNTPVYNWDRGY  150

Query  787   DCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPSGSK  966
               GN T+Q+A+  S N    +   ++G ++ +      G        I   + H+ +   
Sbjct  151   -FGNITLQYALQQSRNVPAVETLNKVGLNRAKTFLNGLG--------IDYPSIHYSNAIS  201

Query  967   PDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSAGNVISTHTEHQLS-  1143
              + T  D        A+  +MA   AA AN G+  +P  + +      V S  +E + S 
Sbjct  202   SNTTESDK----KYGASSEKMAAAYAAFANGGTYYKPMYIHKV-----VFSDGSEKEFSN  252

Query  1144  ---QAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQH  1272
                +A+   TA  +  +M++V+ +GTG NA +  +   GKTGT+ +
Sbjct  253   VGTRAMKETTAYMMTDMMKTVLTYGTGRNAYLAWLPQAGKTGTSNY  298


&gt;2ZC5_B Chain B, Penicillin-Binding Protein 1a (Pbp 1a) Acyl-Enzyme Complex 
(Biapenem) From Streptococcus Pneumoniae
 2ZC5_D Chain D, Penicillin-Binding Protein 1a (Pbp 1a) Acyl-Enzyme Complex 
(Biapenem) From Streptococcus Pneumoniae
 2ZC6_B Chain B, Penicillin-binding Protein 1a (pbp 1a) Acyl-enzyme Complex 
(tebipenem) From Streptococcus Pneumoniae
 2ZC6_D Chain D, Penicillin-binding Protein 1a (pbp 1a) Acyl-enzyme Complex 
(tebipenem) From Streptococcus Pneumoniae
Length=390

 Score = 55.1 bits (131),  Expect = 1e-07, Method: Compositional matrix adjust.
 Identities = 63/226 (28%), Positives = 104/226 (46%), Gaps = 26/226 (12%)
 Frame = +1

Query  613   LNRALRETYPPGSTFKLVT-AATAFETGKYQSPSDVT-DTPDQYILPGTSTPLINASPTE  786
             +N+A+      GST K +T  A A E G Y S + +  D P  Y  PGT+TP+ N     
Sbjct  95    INQAVETNRDWGSTMKPITDYAPALEYGVYDSTATIVHDEPYNY--PGTNTPVYNWDRGY  152

Query  787   DCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPSGSK  966
               GN T+Q+A+  S N    +   ++G ++ +      G        I   + H+ +   
Sbjct  153   -FGNITLQYALQQSRNVPAVETLNKVGLNRAKTFLNGLG--------IDYPSIHYSNAIS  203

Query  967   PDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSAGNVISTHTEHQLS-  1143
              + T  D        A+  +MA   AA AN G+  +P  + +      V S  +E + S 
Sbjct  204   SNTTESDK----KYGASSEKMAAAYAAFANGGTYYKPMYIHKV-----VFSDGSEKEFSN  254

Query  1144  ---QAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQH  1272
                +A+   TA  +  +M++V+ +GTG NA +  +   GKTGT+ +
Sbjct  255   VGTRAMKETTAYMMTDMMKTVLSYGTGQNAYLAWLPQAGKTGTSNY  300


&gt;2C6W_B Chain B, Penicillin-Binding Protein 1a (Pbp-1a) From Streptococcus 
Pneumoniae
Length=384

 Score = 54.7 bits (130),  Expect = 1e-07, Method: Compositional matrix adjust.
 Identities = 63/226 (28%), Positives = 104/226 (46%), Gaps = 26/226 (12%)
 Frame = +1

Query  613   LNRALRETYPPGSTFKLVT-AATAFETGKYQSPSDVT-DTPDQYILPGTSTPLINASPTE  786
             +N+A+      GST K +T  A A E G Y S + +  D P  Y  PGT+TP+ N     
Sbjct  92    INQAVETNRDWGSTMKPITDYAPALEYGVYDSTATIVHDEPYNY--PGTNTPVYNWDRGY  149

Query  787   DCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPSGSK  966
               GN T+Q+A+  S N    +   ++G ++ +      G        I   + H+ +   
Sbjct  150   -FGNITLQYALQQSRNVPAVETLNKVGLNRAKTFLNGLG--------IDYPSIHYSNAIS  200

Query  967   PDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSAGNVISTHTEHQLS-  1143
              + T  D        A+  +MA   AA AN G+  +P  + +      V S  +E + S 
Sbjct  201   SNTTESDK----KYGASSEKMAAAYAAFANGGTYYKPMYIHKV-----VFSDGSEKEFSN  251

Query  1144  ---QAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQH  1272
                +A+   TA  +  +M++V+ +GTG NA +  +   GKTGT+ +
Sbjct  252   VGTRAMKETTAYMMTDMMKTVLTYGTGRNAYLAWLPQAGKTGTSNY  297


&gt;3ZG7_B Chain B, Crystal Structure Of Penicillin-binding Protein 4 From 
Listeria Monocytogenes In The Apo Form
Length=537

 Score = 53.9 bits (128),  Expect = 3e-07, Method: Compositional matrix adjust.
 Identities = 67/238 (28%), Positives = 99/238 (42%), Gaps = 25/238 (11%)
 Frame = +1

Query  613   LNRALRETYPPGSTFK-LVTAATAFETGKYQSPSDVTDTPDQYILPGTSTPLINASPTED  789
              NRA +    PGST K L     A ++G Y   S + D    Y   G  TP  N      
Sbjct  205   FNRATQXKAQPGSTXKPLAVYTPALQSG-YDVDSXLKDEKITY--KGNYTP-TNVGGVY-  259

Query  790   CGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPSGSKP  969
              G      A+  S N     +  ++G DK     EKFG    +T+P            + 
Sbjct  260   SGEVPXYKAVANSINAPAVWLLDQIGIDKGVKSVEKFG----ITVP------------EK  303

Query  970   DGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ-EGSAGNVISTHTEHQLSQ  1146
             D T   A+G     A+P++ A   A  ANNG+  E +++ +    +GN +  +   +  Q
Sbjct  304   DRTLGLALGGXSKGASPVEXATAYATFANNGAKPESHIITKIVDPSGNTVYENVP-KTKQ  362

Query  1147  AVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ-HGQDNSGLPFAWFVSY  1317
              +S   + +    +  V+  GTG +A + G    GKTG+ Q    D SG    WFV Y
Sbjct  363   IISETVSNEXTSXLLDVINTGTGQSAAVSGHEXAGKTGSTQVPFDDTSGTKDQWFVGY  420


&gt;2WAD_A Chain A, Penicillin-binding Protein 2b (pbp-2b) From Streptococcus 
Pneumoniae (strain 5204)
 2WAD_B Chain B, Penicillin-binding Protein 2b (pbp-2b) From Streptococcus 
Pneumoniae (strain 5204)
 2WAD_C Chain C, Penicillin-binding Protein 2b (pbp-2b) From Streptococcus 
Pneumoniae (strain 5204)
Length=680

 Score = 53.5 bits (127),  Expect = 4e-07, Method: Compositional matrix adjust.
 Identities = 88/330 (27%), Positives = 133/330 (40%), Gaps = 58/330 (18%)
 Frame = +1

Query  472   AVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGS  651
             AVA++P+TGA+L +             G K D K    L  D    + N      + PGS
Sbjct  345   AVALNPQTGAVLSM------------SGLKHDLKTG-ELTPDSLGTVTN-----VFVPGS  386

Query  652   TFKLVTAATAFETGKYQSPSDVTDTP----------DQYILPGTSTPLINASPTEDCGNA  801
               K  T ++ +E G       +TD P            Y L   S P+      E   NA
Sbjct  387   VVKAATISSGWENGVLSGNQTLTDQPIVFQGSAPIYSWYKLAYGSFPITAVEALEYSSNA  446

Query  802   -TVQHAMDL-----SCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHF-PSG  960
               VQ A+ +       N   G    E    KLR+   ++G      I +  +++   P  
Sbjct  447   YVVQTALGIMGQTYQPNMFVGTSNLESAMGKLRSTFGEYGLGSATGIDLPDESTGLVPKE  506

Query  961   SKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVA------QEGSAGNVIST  1122
                     +A GQ D   TP+Q+A   A IANNG  + P++V        +G  G +I  
Sbjct  507   YNFANFITNAFGQFDNY-TPMQLAQYVATIANNGVRLAPHIVEGIYDNNDKGGLGELIQA  565

Query  1123  HTEHQLSQA-VSPATAQKLQQLMESVVQHGTG--TNAKI----PGVTVGGKTGTAQH---  1272
                 ++++  +S +    L Q     V HGT   T  +       V++ GKTGT +    
Sbjct  566   IDTKEINKVNISESDMAILHQGFYQ-VSHGTSPLTTGRAFSDGATVSISGKTGTGESYVA  624

Query  1273  -GQDNSGLPFAWFVSYAKGQDGKQVAVAVV  1359
              GQ+ +       V+YA  ++  Q+AVAVV
Sbjct  625   GGQEATN---TNAVAYAPTEN-PQIAVAVV  650


&gt;2WAE_A Chain A, Penicillin-binding Protein 2b (pbp-2b) From Streptococcus 
Pneumoniae (strain 5204)
Length=680

 Score = 53.1 bits (126),  Expect = 6e-07, Method: Compositional matrix adjust.
 Identities = 88/330 (27%), Positives = 133/330 (40%), Gaps = 58/330 (18%)
 Frame = +1

Query  472   AVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGS  651
             AVA++P+TGA+L +             G K D K    L  D    + N      + PGS
Sbjct  345   AVALNPQTGAVLSM------------SGLKHDLKTG-ELTPDSLGTVTN-----VFVPGS  386

Query  652   TFKLVTAATAFETGKYQSPSDVTDTP----------DQYILPGTSTPLINASPTEDCGNA  801
               K  T ++ +E G       +TD P            Y L   S P+      E   NA
Sbjct  387   VVKAATISSGWENGVLSGNQTLTDQPIVFQGSAPIYSWYKLAYGSFPITAVEALEYSSNA  446

Query  802   -TVQHAMDL-----SCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHF-PSG  960
               VQ A+ +       N   G    E    KLR+   ++G      I +  +++   P  
Sbjct  447   YVVQTALGIMGQTYQPNMFVGTSNLESAMGKLRSTFGEYGLGSATGIDLPDESTGLVPKE  506

Query  961   SKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVA------QEGSAGNVIST  1122
                     +A GQ D   TP+Q+A   A IANNG  + P++V        +G  G +I  
Sbjct  507   YNFANFITNAFGQFDNY-TPMQLAQYVATIANNGVRLAPHIVEGIYDNNDKGGLGELIQA  565

Query  1123  HTEHQLSQA-VSPATAQKLQQLMESVVQHGTG--TNAKI----PGVTVGGKTGTAQH---  1272
                 ++++  +S +    L Q     V HGT   T  +       V++ GKTGT +    
Sbjct  566   IDTKEINKVNISESDMAILHQGFYQ-VSHGTSPLTTGRAFSDGATVSISGKTGTGESYVA  624

Query  1273  -GQDNSGLPFAWFVSYAKGQDGKQVAVAVV  1359
              GQ+ +       V+YA  ++  Q+AVAVV
Sbjct  625   GGQEANN---TNAVAYAPTEN-PQIAVAVV  650


&gt;3UDF_A Chain A, Crystal Structure Of Apo Pbp1a From Acinetobacter Baumannii
 3UDF_B Chain B, Crystal Structure Of Apo Pbp1a From Acinetobacter Baumannii
 3UDI_A Chain A, Crystal Structure Of Acinetobacter Baumannii Pbp1a In 
Complex With Penicillin G
 3UDI_B Chain B, Crystal Structure Of Acinetobacter Baumannii Pbp1a In 
Complex With Penicillin G
 3UDX_A Chain A, Crystal Structure Of Acinetobacter Baumannii Pbp1a In 
Complex With Imipenem
 3UDX_B Chain B, Crystal Structure Of Acinetobacter Baumannii Pbp1a In 
Complex With Imipenem
 3UE0_A Chain A, Crystal Structure Of Acinetobacter Baumannii Pbp1a In 
Complex With Aztreonam
 3UE0_B Chain B, Crystal Structure Of Acinetobacter Baumannii Pbp1a In 
Complex With Aztreonam
 3UE1_A Chain A, Crystal Strucuture Of Acinetobacter Baumanni Pbp1a In 
Complex With Mc- 1
 3UE1_B Chain B, Crystal Strucuture Of Acinetobacter Baumanni Pbp1a In 
Complex With Mc- 1
Length=731

 Score = 50.8 bits (120),  Expect = 3e-06, Method: Compositional matrix adjust.
 Identities = 103/421 (24%), Positives = 153/421 (36%), Gaps = 130/421 (31%)
 Frame = +1

Query  367   DMLTGKPKQGGDVVTTID-PKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGT  543
             D++  +P +     + +  PKVQ           G  +AI+P  G+I  +V   ++    
Sbjct  365   DIVRLRPNEAKTAWSLVQVPKVQ-----------GQLIAINPNDGSIEAIVGGYNFYQSK  413

Query  544   FAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSP-SDVT  720
             F                       NRAL+    PGST K    A A E G   +P S V 
Sbjct  414   F-----------------------NRALQGWRQPGSTIKPFLYALALERG--MTPYSMVN  448

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
             D+P   I  G  TP    S     G   ++ A+ LS NTV  ++   +G ++ R     F
Sbjct  449   DSP---ITIGKWTP--KNSDGRYLGMIPLRRALYLSRNTVSVRLLQTVGIERTRQLFMDF  503

Query  901   GFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPY  1080
             G  +E  IP                     I     +  P+QMA   A  AN G  ++P+
Sbjct  504   GL-QEDQIPRNY-----------------TIALGTPQVLPIQMATGYATFANGGYRVQPH  545

Query  1081  LVAQ-EGSAGNVIS-----------------------THTEHQLSQAVSPATAQK-----  1173
              + + E + G VI                        T  + Q+ +  +    QK     
Sbjct  546   FIQRIEDAYGKVIYEAKPEYACIPCINAPETTDDAQVTTPDDQVVEVTNKELEQKEKTTK  605

Query  1174  ----------------LQQLMES------------VVQHGTGTNA-KIPGVTVGGKTGTA  1266
                              Q++++S            V++HGTG  A KI    +GGKTGT 
Sbjct  606   QLNLKQTDKNNSQYRQAQRILKSSSAYDMANILRDVIEHGTGRAALKIGRSDLGGKTGTT  665

Query  1267  QHGQDNSGLPFAWFVSYAKGQDGKQVAVAVV-VEDGSSEAQQISGGSLAAPIAKAMMQAA  1443
                +D      AWF     G +GK V V  V  +  ++  ++  GG  A PI    M  A
Sbjct  666   NDAKD------AWFA----GFNGKLVTVTWVGFDQPTTLGRREYGGIAALPIWINFMGQA  715

Query  1444  L  1446
             L
Sbjct  716   L  716


&gt;1K25_A Chain A, PBP2x from a Highly Penicillin-resistant Streptococcus 
pneumoniae Clinical Isolate
 1K25_B Chain B, PBP2x from a Highly Penicillin-resistant Streptococcus 
pneumoniae Clinical Isolate
 1K25_C Chain C, PBP2x from a Highly Penicillin-resistant Streptococcus 
pneumoniae Clinical Isolate
 1K25_D Chain D, PBP2x from a Highly Penicillin-resistant Streptococcus 
pneumoniae Clinical Isolate
Length=685

 Score = 49.7 bits (117),  Expect = 6e-06, Method: Compositional matrix adjust.
 Identities = 88/379 (23%), Positives = 141/379 (37%), Gaps = 83/379 (22%)
 Frame = +1

Query  295   SQLEKLEDGILSGTDSRLFFRNT--------LDMLTGKPKQGGDVVTTIDPKVQK-----  435
             S +E   + IL+GTD  + +            ++++ +   G DV TT+   +Q      
Sbjct  152   SGMESSLNSILAGTDGIITYEKDRVGNIVPGTELVSQQTVDGKDVYTTLSSPLQSFMETQ  211

Query  436   --AGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKP  609
               A  E +  K   A  +  KTG IL     P+++  T  G T+D    W  +    N  
Sbjct  212   MDAFLEKVKGKYMTATLVSAKTGEILATTQRPTFNADTKEGITED--FVWRDILYQSN--  267

Query  610   MLNRALRETYPPGSTFKLVTAATA-----FETGKYQSPSDV----TDTPDQYILPGTSTP  762
                      Y PGS  K++T A++     F +G+Y + S++      T D  +  G +T 
Sbjct  268   ---------YEPGSAMKVMTLASSIDNNTFPSGEYFNSSELKIADATTRDWDVNEGLTT-  317

Query  763   LINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADA  942
                       G  T       S N     +  ++G        ++F F     +P R   
Sbjct  318   ---------GGMMTFLQGFAHSSNVGMSLLEQKMGDATWLDYLKRFKFG----VPTRFGL  364

Query  943   SHFPSGSKPD----GTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLV--------  1086
             +   +G  P       A  + GQ     T  QM     AIAN+G ++EP  +        
Sbjct  365   TDEYAGQLPADNIVSIAQSSFGQ-GISVTQTQMLRAFTAIANDGVMLEPKFISAIYDTNN  423

Query  1087  -----AQEGSAGNVI-----STHTEHQLSQAVSPATAQKLQQLMESVVQHGTGT-NAKIP  1233
                  +Q+   GN +     ST   H +     P        L  ++  H TG     +P
Sbjct  424   QSVRKSQKEIVGNPVSKEAASTTRNHMILVGTDP--------LYGTMYNHYTGKPIITVP  475

Query  1234  GVTVGGKTGTAQHGQDNSG  1290
             G  V  K+GTAQ   + +G
Sbjct  476   GQNVAVKSGTAQIADEKNG  494


&gt;5U47_A Chain A, 1.95 Angstrom Resolution Crystal Structure Of Penicillin 
Binding Protein 2x From Streptococcus Thermophilus
Length=707

 Score = 48.9 bits (115),  Expect = 1e-05, Method: Compositional matrix adjust.
 Identities = 91/364 (25%), Positives = 141/364 (39%), Gaps = 56/364 (15%)
 Frame = +1

Query  301   LEKLEDGILSGTDSRLFFR-----NTL---DMLTGKPKQGGDVVTTIDPKVQK-------  435
             LE+  + +L+GTD    +      NTL   + +T +   G ++ TT+   +Q        
Sbjct  176   LERSLNSLLTGTDGEAIYEKDKDGNTLLGTETITKEAIDGKNIYTTLSAPLQTFLETQMD  235

Query  436   AGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPML  615
                E       +A  ++ KTG IL     P+Y+  T  G  K     W           +
Sbjct  236   TFMEQTKGINASATVVNAKTGEILATTQRPTYNSDTLEGQAKKGYD-W-----------V  283

Query  616   NRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTSTPLINASPTEDCG  795
             NR     Y PGST K++  + A   G +    + T +    I  G    + + S  E   
Sbjct  284   NRLYEAQYEPGSTMKVMLLSAAINNGSFN--PNATYSNANGIKVG-DVEINDWSINEGIS  340

Query  796   NA-TVQHAMDLSCNTVFG-KMGAELGGDKLRAQ---AEKFGFNKEVTIPIRADASHFPSG  960
                T+  A   S ++  G  M  +  GDK+ +      KFG      IP R       SG
Sbjct  341   KGRTMSFAQGFSYSSNVGMTMLEQAMGDKVWSNYLSLYKFG------IPTRFGMVGESSG  394

Query  961   SKPDGT---AMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSAGN-VISTHT  1128
                  +   A  + GQ     T +QM     AI+NNG ++EP  + Q        + T  
Sbjct  395   IVSQNSVNIAQSSFGQG-ISVTQVQMLRAFTAISNNGIMLEPQFIKQVADTNKGTVRTAK  453

Query  1129  EHQLSQAVSPATAQKLQQLMESV---VQHGTGTNAK--IPGVTVGG-----KTGTAQHGQ  1278
             +  + + VS   A + +  M SV    + GT  N     P + VG      K+GTAQ   
Sbjct  454   KEVIGKPVSKQAASETRNYMISVGTDPEFGTLYNKSEGSPIIQVGNNDVTVKSGTAQVPD  513

Query  1279  DNSG  1290
             + +G
Sbjct  514   EKTG  517


&gt;1RP5_A Chain A, Pbp2x From Streptococcus Pneumoniae Strain 5259 With 
Reduced Susceptibility To Beta-Lactam Antibiotics
 1RP5_B Chain B, Pbp2x From Streptococcus Pneumoniae Strain 5259 With 
Reduced Susceptibility To Beta-Lactam Antibiotics
Length=702

 Score = 47.4 bits (111),  Expect = 4e-05, Method: Compositional matrix adjust.
 Identities = 89/374 (24%), Positives = 138/374 (37%), Gaps = 73/374 (20%)
 Frame = +1

Query  295   SQLEKLEDGILSGTDSRLFFRNT--------LDMLTGKPKQGGDVVTTIDPKVQK-----  435
             S +E   + IL+GTD  + +            + ++ +   G DV TTI   +Q      
Sbjct  169   SGMESSLNSILAGTDGIITYEKDRLGNIVPGTEQVSQQTVDGKDVYTTISSPLQSFMETQ  228

Query  436   --AGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKP  609
               A  E +  K   A  +  KTG IL     P++D  T  G T+D    W  +    N  
Sbjct  229   MDAFQEKVKGKYMTATLVSAKTGEILATTQRPTFDADTKEGITED--FVWRDILYQSN--  284

Query  610   MLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTSTPL-INASPTE  786
                      Y PGST K++  A A +   +    +V ++ +  I   T     +N   T 
Sbjct  285   ---------YEPGSTMKVMMLAAAIDNNTFPG-GEVFNSSELKIADATIRDWDVNEGLTG  334

Query  787   DCGNATVQ---HAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPS  957
                    Q   H+ ++    +  KMG     D L     +F F     +P R   +   +
Sbjct  335   GRMMTFSQGFAHSSNVGMTLLEQKMGDATWLDYLN----RFKFG----VPTRFGLTDEYA  386

Query  958   GSKPD----GTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLV-------------  1086
             G  P       AM A GQ     T  QM     AIAN+G ++EP  +             
Sbjct  387   GQLPADNIVNIAMSAFGQ-GISVTQTQMLRAFTAIANDGVMLEPKFISALYDPNDQSVRK  445

Query  1087  AQEGSAGNVISTHT-----EHQLSQAVSPATAQKLQQLMESVVQHGTG-TNAKIPGVTVG  1248
             +Q+   GN +S        +H +     P           ++  H TG     +PG  V 
Sbjct  446   SQKEIVGNPVSKEAASVTRDHMVMVGTDPTYG--------TMYNHSTGKATVNVPGQNVA  497

Query  1249  GKTGTAQHGQDNSG  1290
              K+GTA+   + +G
Sbjct  498   LKSGTAEIADEKNG  511


&gt;4OON_A Chain A, Crystal Structure Of Pbp1a In Complex With Compound 
17 ((4z,8s,11e, 14s)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3- 
Dihydro-2h-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11- 
Triazatetradeca-4,11-diene-2,12,14-tricarboxylic 
Acid)
Length=795

 Score = 46.6 bits (109),  Expect = 7e-05, Method: Compositional matrix adjust.
 Identities = 94/401 (23%), Positives = 150/401 (37%), Gaps = 87/401 (22%)
 Frame = +1

Query  385   PKQGGDVVTTIDP-KVQKA-----GFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTF  546
             P+Q  DV    D  +VQ+       F  +   + A +++DPK GAI  LV   S++   +
Sbjct  363   PRQPADVAQAGDQIRVQRQEDGTLRFVQIPAAQSALISLDPKDGAIRSLVGGFSFEQSNY  422

Query  547   AGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDT  726
                                    NRA++    PGS+FK    + A + G + + S V D 
Sbjct  423   -----------------------NRAIQAKRQPGSSFKPFIYSAALDNG-FTAASLVNDA  458

Query  727   P----DQYI----LPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLR  882
             P    D+Y+     P   T           G   ++ A+  S N V  ++   LG ++  
Sbjct  459   PIVFVDEYLDKVWRPKNDTNTF-------LGPIPLREALYKSRNMVSIRVLQGLGIERAI  511

Query  883   AQAEKFGFNKE---------------VTIPIRADASHFPSGS-KPDGTAMDAI----GQH  1002
             +   KFGF ++                 + I    S F +G  K +   ++ I    GQ 
Sbjct  512   SYITKFGFQRDELPRNFSLALGTATVTPMEIAGAWSVFANGGYKVNPYVIERIESRDGQV  571

Query  1003  DTRATP------LQMAMVAAAIANNGSLMEPYLVAQEGS------AGNVISTHTEHQLSQ  1146
               +A P       Q+A  A    N G    P     EGS      A    +T       +
Sbjct  572   LYQANPPRVPVEEQVAADAEDAGNPGDPEHPESAEGEGSIEAQQVAAKAQTTFEPTPAER  631

Query  1147  AVSPATAQKLQQLMESVVQHGTGTNA-KIPGVTVGGKTGTAQHGQDNSGLPFAWFVSYAK  1323
              +   TA  +  +++ V++ GTG  A  +    + GKTGT    +D       WF  Y  
Sbjct  632   IIDARTAYIMTSMLQDVIKRGTGRRALALKRTDLAGKTGTTNDSKD------GWFSGY--  683

Query  1324  GQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAAL  1446
                    +V V  +   +  ++  GG++A PI    M  AL
Sbjct  684   -NSDYVTSVWVGFDQPETLGRREYGGTVALPIWIRYMGFAL  723


&gt;1PYY_A Chain A, Double Mutant Pbp2x T338aM339F FROM STREPTOCOCCUS PNEUMONIAE 
STRAIN R6 At 2.4 A Resolution
Length=702

 Score = 43.9 bits (102),  Expect = 4e-04, Method: Compositional matrix adjust.
 Identities = 86/366 (23%), Positives = 138/366 (38%), Gaps = 57/366 (16%)
 Frame = +1

Query  295   SQLEKLEDGILSGTDSRLFFRNT--------LDMLTGKPKQGGDVVTTIDPKVQK-----  435
             S +E   + IL+GTD  + +            + ++ +   G DV TTI   +Q      
Sbjct  169   SGMESSLNSILAGTDGIITYEKDRLGNIVPGTEQVSQRTMDGKDVYTTISSPLQSFMETQ  228

Query  436   --AGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKP  609
               A  E +  K   A  +  KTG IL     P++D  T  G T+D    W  +    N  
Sbjct  229   MDAFQEKVKGKYMTATLVSAKTGEILATTQRPTFDADTKEGITED--FVWRDILYQSN--  284

Query  610   MLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTSTPL-INASPTE  786
                      Y PGS FK++  A A +   +    +V ++ +  I   T     +N   T 
Sbjct  285   ---------YEPGSAFKVMMLAAAIDNNTFPG-GEVFNSSELKIADATIRDWDVNEGLTG  334

Query  787   DCGNATVQ---HAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPS  957
                    Q   H+ ++    +  KMG     D L     +F F     +P R   +   +
Sbjct  335   GRMMTFSQGFAHSSNVGMTLLEQKMGDATWLDYLN----RFKFG----VPTRFGLTDEYA  386

Query  958   GSKPD----GTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSAGNVISTH  1125
             G  P       A  + GQ     T  QM     AIAN+G ++EP  ++      +  +  
Sbjct  387   GQLPADNIVNIAQSSFGQ-GISVTQTQMIRAFTAIANDGVMLEPKFISAIYDPNDQTARK  445

Query  1126  TEHQL-SQAVSPATAQKLQQLME---------SVVQHGTGT-NAKIPGVTVGGKTGTAQH  1272
             ++ ++    VS   A   +  M          ++  H TG     +PG  V  K+GTAQ 
Sbjct  446   SQKEIVGNPVSKDAASLTRTNMVLVGTDPVYGTMYNHSTGKPTVTVPGQNVALKSGTAQI  505

Query  1273  GQDNSG  1290
               + +G
Sbjct  506   ADEKNG  511


&gt;1PMD_A Chain A, Penicillin-Binding Protein 2x (Pbp-2x)
Length=675

 Score = 43.5 bits (101),  Expect = 5e-04, Method: Compositional matrix adjust.
 Identities = 86/366 (23%), Positives = 138/366 (38%), Gaps = 57/366 (16%)
 Frame = +1

Query  295   SQLEKLEDGILSGTDSRLFFRNT--------LDMLTGKPKQGGDVVTTIDPKVQK-----  435
             S +E   + IL+GTD  + +            + ++ +   G DV TTI   +Q      
Sbjct  142   SGMESSLNSILAGTDGIITYEKDRLGNIVPGTEQVSQRTMDGKDVYTTISSPLQSFMETQ  201

Query  436   --AGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKP  609
               A  E +  K   A  +  KTG IL     P++D  T  G T+D    W  +    N  
Sbjct  202   MDAFQEKVKGKYMTATLVSAKTGEILATTQRPTFDADTKEGITED--FVWRDILYQSN--  257

Query  610   MLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTSTPL-INASPTE  786
                      Y PGST K++  A A +   +    +V ++ +  I   T     +N   T 
Sbjct  258   ---------YEPGSTMKVMMLAAAIDNNTFPG-GEVFNSSELKIADATIRDWDVNEGLTG  307

Query  787   DCGNATVQ---HAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPS  957
                    Q   H+ ++    +  KMG     D L     +F F     +P R   +   +
Sbjct  308   GRMMTFSQGFAHSSNVGMTLLEQKMGDATWLDYLN----RFKFG----VPTRFGLTDEYA  359

Query  958   GSKPD----GTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSAGNVISTH  1125
             G  P       A  + GQ     T  QM     AIAN+G ++EP  ++      +  +  
Sbjct  360   GQLPADNIVNIAQSSFGQG-ISVTQTQMIRAFTAIANDGVMLEPKFISAIYDPNDQTARK  418

Query  1126  TEHQL-SQAVSPATAQKLQQLME---------SVVQHGTGT-NAKIPGVTVGGKTGTAQH  1272
             ++ ++    VS   A   +  M          ++  H TG     +PG  V  K+GTAQ 
Sbjct  419   SQKEIVGNPVSKDAASLTRTNMVLVGTDPVYGTMYNHSTGKPTVTVPGQNVALKSGTAQI  478

Query  1273  GQDNSG  1290
               + +G
Sbjct  479   ADEKNG  484


&gt;1QME_A Chain A, Penicillin-binding Protein 2x (pbp-2x)
 1QMF_A Chain A, Penicillin-binding Protein 2x (pbp-2x) Acyl-enzyme Complex
Length=702

 Score = 43.1 bits (100),  Expect = 7e-04, Method: Compositional matrix adjust.
 Identities = 86/366 (23%), Positives = 138/366 (38%), Gaps = 57/366 (16%)
 Frame = +1

Query  295   SQLEKLEDGILSGTDSRLFFRNT--------LDMLTGKPKQGGDVVTTIDPKVQK-----  435
             S +E   + IL+GTD  + +            + ++ +   G DV TTI   +Q      
Sbjct  169   SGMESSLNSILAGTDGIITYEKDRLGNIVPGTEQVSQRTMDGKDVYTTISSPLQSFMETQ  228

Query  436   --AGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKP  609
               A  E +  K   A  +  KTG IL     P++D  T  G T+D    W  +    N  
Sbjct  229   MDAFQEKVKGKYMTATLVSAKTGEILATTQRPTFDADTKEGITED--FVWRDILYQSN--  284

Query  610   MLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTSTPL-INASPTE  786
                      Y PGST K++  A A +   +    +V ++ +  I   T     +N   T 
Sbjct  285   ---------YEPGSTMKVMMLAAAIDNNTFPG-GEVFNSSELKIADATIRDWDVNEGLTG  334

Query  787   DCGNATVQ---HAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNKEVTIPIRADASHFPS  957
                    Q   H+ ++    +  KMG     D L     +F F     +P R   +   +
Sbjct  335   GRMMTFSQGFAHSSNVGMTLLEQKMGDATWLDYLN----RFKFG----VPTRFGLTDEYA  386

Query  958   GSKPD----GTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSAGNVISTH  1125
             G  P       A  + GQ     T  QM     AIAN+G ++EP  ++      +  +  
Sbjct  387   GQLPADNIVNIAQSSFGQ-GISVTQTQMIRAFTAIANDGVMLEPKFISAIYDPNDQTARK  445

Query  1126  TEHQL-SQAVSPATAQKLQQLME---------SVVQHGTGT-NAKIPGVTVGGKTGTAQH  1272
             ++ ++    VS   A   +  M          ++  H TG     +PG  V  K+GTAQ 
Sbjct  446   SQKEIVGNPVSKDAASLTRTNMVLVGTDPVYGTMYNHSTGKPTVTVPGQNVALKSGTAQI  505

Query  1273  GQDNSG  1290
               + +G
Sbjct  506   ADEKNG  511


&gt;4YE5_A Chain A, The Crystal Structure Of A Peptidoglycan Synthetase 
From Bifidobacterium Adolescentis Atcc 15703
 4YE5_B Chain B, The Crystal Structure Of A Peptidoglycan Synthetase 
From Bifidobacterium Adolescentis Atcc 15703
Length=566

 Score = 42.7 bits (99),  Expect = 8e-04, Method: Compositional matrix adjust.
 Identities = 85/405 (21%), Positives = 158/405 (39%), Gaps = 55/405 (14%)
 Frame = +1

Query  301   LEKLEDGILSGTDSRLFFR--NTLDMLTGKPKQ------GGDVVTTIDPKVQKAGFEGLG  456
             +E+ E+  L+G D    ++  N+   + G   +      G DV  TID  VQ    + L 
Sbjct  173   IEQXENKTLTGRDGYQVYQQGNSGVEIPGTXTESKDAVNGSDVTLTIDRDVQWYTEKVLS  232

Query  457   NKK-------GAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSDPNKPML  615
             + +       G A   D ++G IL L  + + + G                 SD  K   
Sbjct  233   DSENKYHSAWGIAXVQDVQSGDILALADSDTTEAG-----------------SDQAKXGA  275

Query  616   NRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTSTPLINASPTEDCG  795
             +RA+ ET+ PGS  K++  +   + G ++         D++ +P T T  +     +D  
Sbjct  276   SRAVSETFEPGSIGKVLAXSGXLQLGLHK-------IDDKFTVPNTVT--VEGQTYKDAV  326

Query  796   NATVQHAMDLSCNTVFGKMGAELGGDKLRAQAE-----KFGFNKE--VTIPIRADASHFP  954
             +   +H            +G  + GDK   +       KFG  +   + +P  ++    P
Sbjct  327   DHGNEHWTLAGILEQSSNVGXVIAGDKXTNEQRYNFISKFGIGQATGLNLPGESEGVLHP  386

Query  955   SGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQE--GSAGNVISTHT  1128
             S S    T    +          Q+    + IAN G + +P  + +    +AG+V    +
Sbjct  387   SDSWDRRTRNTVLFGQGYTVNVXQLTNAISVIANKG-VKKPQRIIKSITDTAGHVEEQQS  445

Query  1129  EHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQHGQDNSGLPFAWF  1308
             + + ++ +  + A +     ES  +H   T  K+ G     K+GTA+    N  L  +  
Sbjct  446   KGEATRVIDESVASQXLNAXESSAEH-YNTFVKVDGYRXAAKSGTAEVAGANGQLT-SII  503

Query  1309  VSYAK--GQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQ  1437
               Y+     D  +  + VV++D       ++ G + A I + + Q
Sbjct  504   SDYSTIIPADNPRFVITVVLKDPQGSFGGLTAGPVTAEIGEFLXQ  548


&gt;3DWK_A Chain A, Identification Of Dynamic Structural Motifs Involved 
In Peptidoglycan Glycosyltransfer
 3DWK_B Chain B, Identification Of Dynamic Structural Motifs Involved 
In Peptidoglycan Glycosyltransfer
 3DWK_C Chain C, Identification Of Dynamic Structural Motifs Involved 
In Peptidoglycan Glycosyltransfer
 3DWK_D Chain D, Identification Of Dynamic Structural Motifs Involved 
In Peptidoglycan Glycosyltransfer
Length=625

 Score = 42.4 bits (98),  Expect = 0.001, Method: Compositional matrix adjust.
 Identities = 69/303 (23%), Positives = 120/303 (40%), Gaps = 61/303 (20%)
 Frame = +1

Query  400   DVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAW  579
             DV  T+   V    F    +++  A  +D KTG ++ +             G +D     
Sbjct  271   DVQKTLQNDVDNGSFYKNKDQQVGATILDSKTGGLVAI------------SGGRD-----  313

Query  580   TALDSDPNKPMLNR-ALRETYPPGSTFK-LVTAATAFETGKYQSPSDVTDTPDQYILPGT  753
                     K ++NR    + +P GS+ K  +    A E  K+ +   + D    Y + G+
Sbjct  314   -------FKDVVNRNQATDPHPTGSSLKPFLAYGPAIENMKWATNHAIQDES-SYQVDGS  365

Query  754   STPLINASPTEDCGNATVQHAMDLSCNT----VFGKMGAELGGDKLRAQAEKFGFNKEVT  921
             +        T+  G  ++  A+  S N      +  +    G D  +  A K G N E  
Sbjct  366   T---FRNYDTKSHGTVSIYDALRQSFNIPALKAWQSVKQNAGNDAPKKFAAKLGLNYEGD  422

Query  922   IPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPY----LVA  1089
             I         PS         + +G   +  +P Q+A   AAIAN G+    +    +V 
Sbjct  423   IG--------PS---------EVLGGSASEFSPTQLASAFAAIANGGTYNNAHSIQKVVT  465

Query  1090  QEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQ-HGTGTNAKIPGVTVGGKTGTA  1266
             ++G    +   HT H   +A+S  TA  L ++++   + +G+     + GV +G KTGT 
Sbjct  466   RDGET--IEYDHTSH---KAMSDYTAYMLAEMLKGTFKPYGSAYGHGVSGVNMGAKTGTG  520

Query  1267  QHG  1275
              +G
Sbjct  521   TYG  523


&gt;2Z2L_B Chain B, Penicillin-binding Protein 2x (pbp2x) From Streptococcus 
Pneumoniae
 2Z2L_E Chain E, Penicillin-binding Protein 2x (pbp2x) From Streptococcus 
Pneumoniae
 2Z2M_B Chain B, Cefditoren-acylated Penicillin-binding Protein 2x (pbp2x) 
From Streptococcus Pneumoniae
 2Z2M_E Chain E, Cefditoren-acylated Penicillin-binding Protein 2x (pbp2x) 
From Streptococcus Pneumoniae
 2ZC3_B Chain B, Penicillin-Binding Protein 2x (Pbp 2x) Acyl-Enzyme Complex 
(Biapenem) From Streptococcus Pneumoniae
 2ZC3_E Chain E, Penicillin-Binding Protein 2x (Pbp 2x) Acyl-Enzyme Complex 
(Biapenem) From Streptococcus Pneumoniae
 2ZC4_B Chain B, Penicillin-Binding Protein 2x (Pbp 2x) Acyl-Enzyme Complex 
(Tebipenem) From Streptococcus Pneumoniae
 2ZC4_E Chain E, Penicillin-Binding Protein 2x (Pbp 2x) Acyl-Enzyme Complex 
(Tebipenem) From Streptococcus Pneumoniae
Length=385

 Score = 40.4 bits (93),  Expect = 0.004, Method: Compositional matrix adjust.
 Identities = 79/334 (24%), Positives = 126/334 (38%), Gaps = 49/334 (15%)
 Frame = +1

Query  367   DMLTGKPKQGGDVVTTIDPKVQK-------AGFEGLGNKKGAAVAIDPKTGAILGLVSTP  525
             + ++ +   G DV TTI   +Q        A  E +  K   A  +  KTG IL     P
Sbjct  9     EQVSQRTMDGKDVYTTISSPLQSFMETQMDAFQEKVKGKYMTATLVSAKTGEILATTQRP  68

Query  526   SYDPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQS  705
             ++D  T  G T+D    W  +    N           Y PGST K++  A A +   +  
Sbjct  69    TFDADTKEGITED--FVWRDILYQSN-----------YEPGSTMKVMMLAAAIDNNTFPG  115

Query  706   PSDVTDTPDQYILPGTSTPL-INASPTEDCGNATVQ---HAMDLSCNTVFGKMGAELGGD  873
               +V ++ +  I   T     +N   T        Q   H+ ++    +  KMG     D
Sbjct  116   -GEVFNSSELKIADATIRDWDVNEGLTGGRMMTFSQGFAHSSNVGMTLLEQKMGDATWLD  174

Query  874   KLRAQAEKFGFNKEVTIPIRADASHFPSGSKPD----GTAMDAIGQHDTRATPLQMAMVA  1041
              L     +F F     +P R   +   +G  P       A  + GQ     T  QM    
Sbjct  175   YLN----RFKFG----VPTRFGLTDEYAGQLPADNIVNIAQSSFGQG-ISVTQTQMIRAF  225

Query  1042  AAIANNGSLMEPYLVAQEGSAGNVISTHTEHQL-SQAVSPATAQKLQQLME---------  1191
              AIAN+G ++EP  ++      +  +  ++ ++    VS   A   +  M          
Sbjct  226   TAIANDGVMLEPKFISAIYDPNDQTARKSQKEIVGNPVSKDAASLTRTNMVLVGTDPVYG  285

Query  1192  SVVQHGTGT-NAKIPGVTVGGKTGTAQHGQDNSG  1290
             ++  H TG     +PG  V  K+GTAQ   + +G
Sbjct  286   TMYNHSTGKPTVTVPGQNVALKSGTAQIADEKNG  319


  Database: PDB protein database
    Posted date:  Mar 2, 2018  2:31 PM
  Number of letters in database: 24,642,510
  Number of sequences in database:  97,497

Lambda      K        H
   0.314    0.131    0.383 
Gapped
Lambda      K        H
   0.267   0.0410    0.140 
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 97497
Number of Hits to DB: 8556081
Number of extensions: 233942
Number of successful extensions: 991
Number of sequences better than 10: 26
Number of HSP&#39;s better than 10 without gapping: 0
Number of HSP&#39;s gapped: 950
Number of HSP&#39;s successfully gapped: 42
Length of query: 1455
Length of database: 24642510
Length adjustment: 106
Effective length of query: 1349
Effective length of database: 14307828
Effective search space: 5422666812
Effective search space used: 5422666812
T: 12
A: 40
X1: 16 (7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (20.4 bits)
S2: 64 (29.3 bits)
ka-blk-alpha gapped: 1.9
ka-blk-alpha ungapped: 0.7916
ka-blk-alpha_v gapped: 42.6028
ka-blk-alpha_v ungapped: 4.96466
ka-blk-sigma gapped: 43.6362


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<h3>QUESTIONS</h3>
<ol>
<li> How is this output different to that from command-line and web-interface `BLAST` results?
<li> How many hits are there?
<li> What is the "best hit" to the query? Do you think it is a 'good' hit?
<li> At what point do you think the matches start to become less reliable? Why do you think this? (*HINT:* inspect the alignments)
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<p><a id="save"></a></p>
<h3 id="Save-BLASTX-results-to-file">Save <code>BLASTX</code> results to file<a class="anchor-link" href="#Save-BLASTX-results-to-file">&#182;</a></h3><p>The results you obtianed above are human-readable, and similar to the default output type you saw from command-line/terminal <code>BLAST</code> in <a href="02-blast_at_terminal.ipynb">notebook 02</a>. But, for now, they exist only in the variable called <code>output</code>. If we want to come back to these results at some time in the future, we will need to save them to a file somewhere.</p>
<p>This is a common operation in programmatic approaches to bioinformatics: once a result is obtained, we usually want to save it to a file. Most command-line programs will do this for you, but when working programmatically mostly you will need to save it explicitly, yourself.</p>
<p>The Python code for saving the contents of <code>output</code> to the file <code>output/kitasatospora/remote_blastx_query_01.txt</code> is given in the cell below:</p>

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<div class=" highlight hl-ipython3"><pre><span></span><span class="c1"># Make directory to save output, if it doesn&#39;t exist</span>
<span class="n">outdir</span> <span class="o">=</span> <span class="n">os</span><span class="o">.</span><span class="n">path</span><span class="o">.</span><span class="n">join</span><span class="p">(</span><span class="s2">&quot;output&quot;</span><span class="p">,</span> <span class="s2">&quot;kitasatospora&quot;</span><span class="p">)</span>
<span class="n">os</span><span class="o">.</span><span class="n">makedirs</span><span class="p">(</span><span class="n">outdir</span><span class="p">,</span> <span class="n">exist_ok</span><span class="o">=</span><span class="kc">True</span><span class="p">)</span>

<span class="c1"># Save output to file</span>
<span class="n">outfilename</span> <span class="o">=</span> <span class="n">os</span><span class="o">.</span><span class="n">path</span><span class="o">.</span><span class="n">join</span><span class="p">(</span><span class="n">outdir</span><span class="p">,</span> <span class="s2">&quot;remote_blastx_query_01.txt&quot;</span><span class="p">)</span>
<span class="k">with</span> <span class="nb">open</span><span class="p">(</span><span class="n">outfilename</span><span class="p">,</span> <span class="s1">&#39;w&#39;</span><span class="p">)</span> <span class="k">as</span> <span class="n">outfh</span><span class="p">:</span>
    <span class="n">outfh</span><span class="o">.</span><span class="n">write</span><span class="p">(</span><span class="n">output</span><span class="p">)</span>
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<p>This code does three main things:</p>
<ol>
<li>It creates a variable called <code>outfilename</code>, with the path to the file we want to write</li>
<li>It opens that file, ready for writing, as a <em>handle</em> called <code>outfh</code></li>
<li>It writes the contents of <code>output</code> into the <code>outfh</code> <em>handle</em> (and then closes the <em>handle</em>)</li>
</ol>
<p>When this is done, the <code>BLAST</code> search results we got from NCBI are written to the file <code>output/kitasatospora/remote_blastx_query_01.txt</code>, just as though we did the search locally. You can inspect the contents of that file at the terminal using the command:</p>
<div class="highlight"><pre><span></span>less output/kitasatospora/remote_blastx_query_01.txt
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<p><a id="entrez"></a></p>
<h3 id="Using-Entrez-queries-to-modify-the-remote-database">Using Entrez queries to modify the remote database<a class="anchor-link" href="#Using-Entrez-queries-to-modify-the-remote-database">&#182;</a></h3><p>The remote NCBI <code>BLAST+</code> service provides large, comprehensive databases such as <code>nr</code>, <code>nt</code> and <code>refseq</code>, but it doesn't provide very many specialised databases. Searches against large databases - where you don't care about most of the sequences, and most of the sequences are unlikely to match - can be wasteful and take longer than necessary to get the useful answer you're looking for. But a smaller, specialised organism-centric database - which would be much quicker to search - may not exist separately.</p>
<p><p></p></p>
<div class="alert-success">
<b>NCBI provide a service called `Entrez E-Utilities` which allows for complex text-based searches to be defined. A detailed consideration of this very powerful tool is beyond the scope of this course, but we will use the service to replicate the `Organism` field of the NCBI web browser interface that allowed us to restrict the `nr` database only to <i>Kitasatospora</i> sequences.</b>
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<p>In <a href="01-blast_at_NCBI_website.ipynb">notebook 01</a> you used the <code>Organism</code> field in the web browser interface to specify <code>Kitasatospora (taxid: 2063)</code> when querying against the complete <code>nr</code> database. This had the effect of only querying against sequences in <code>nr</code> that originated from <em>Kitasatospora</em>, reducing the overall search time and giving you the relevant hits you needed without producing a very large set of output.</p>
<p>To perform a similar filtering of the search using <code>NCBIWWW.qblast()</code>, you specify the argument <code>entrez_query</code>. The value to be passed is a string that describes the search field you want to filter on. There are many search field options (see the <a href="https://www.ncbi.nlm.nih.gov/books/NBK49540/">list here</a>), but we will use only one in this lesson: the <code>organism</code> field.</p>
<p><p></p></p>
<div class="alert-warning">
<b>The `Entrez` query syntax is the same syntax that you would use in any browser-based NCBI database search, and is reported back to you when you refine searches at NCBI. Looking at that output is a good way to find interesting ways to slice large databases into smaller subsets of interest.</b>
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<h4 id="The-organism-field-[ORGN]">The <code>organism</code> field <code>[ORGN]</code><a class="anchor-link" href="#The-organism-field-[ORGN]">&#182;</a></h4><p>The syntax for filtering on organism is <code>&lt;value&gt;[ORGN]</code> where <code>&lt;value&gt;</code> is the term you want to filter on. This can be the name of the organism, or an identifier such as the NCBI taxon ID.</p>
<p><p></p></p>
<div class="alert-warning">
<b>In the cell below, the remote search is conducted on the `nr` database, but restricted only to the set of sequences originating from *Kitasatospora*, by specififying `entrez_query="kitasatospora[ORGN]"`:</b>
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<div class=" highlight hl-ipython3"><pre><span></span><span class="c1"># Repeat the BLAST search on the nr database, restricted to Kitasatospora spp.</span>
<span class="n">result_handle</span> <span class="o">=</span> <span class="n">NCBIWWW</span><span class="o">.</span><span class="n">qblast</span><span class="p">(</span><span class="s2">&quot;blastx&quot;</span><span class="p">,</span> <span class="s2">&quot;nr&quot;</span><span class="p">,</span> <span class="n">seq</span><span class="o">.</span><span class="n">format</span><span class="p">(</span><span class="s2">&quot;fasta&quot;</span><span class="p">),</span>
                               <span class="n">entrez_query</span><span class="o">=</span><span class="s2">&quot;kitasatospora[ORGN]&quot;</span><span class="p">,</span>
                               <span class="n">format_type</span><span class="o">=</span><span class="s2">&quot;Text&quot;</span><span class="p">)</span>
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<div class=" highlight hl-ipython3"><pre><span></span><span class="c1"># Show human-readable results</span>
<span class="n">output</span> <span class="o">=</span> <span class="n">result_handle</span><span class="o">.</span><span class="n">read</span><span class="p">()</span>
<span class="nb">print</span><span class="p">(</span><span class="n">output</span><span class="p">)</span>

<span class="c1"># Save output to file</span>
<span class="n">outfilename</span> <span class="o">=</span> <span class="n">os</span><span class="o">.</span><span class="n">path</span><span class="o">.</span><span class="n">join</span><span class="p">(</span><span class="n">outdir</span><span class="p">,</span> <span class="s2">&quot;remote_blastx_query_02.txt&quot;</span><span class="p">)</span>
<span class="k">with</span> <span class="nb">open</span><span class="p">(</span><span class="n">outfilename</span><span class="p">,</span> <span class="s1">&#39;w&#39;</span><span class="p">)</span> <span class="k">as</span> <span class="n">outfh</span><span class="p">:</span>
    <span class="n">outfh</span><span class="o">.</span><span class="n">write</span><span class="p">(</span><span class="n">output</span><span class="p">)</span>
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<pre>&lt;p&gt;&lt;!--
QBlastInfoBegin
	Status=READY
QBlastInfoEnd
--&gt;&lt;p&gt;
&lt;PRE&gt;
BLASTX 2.8.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro
A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and
David J. Lipman (1997), &#34;Gapped BLAST and PSI-BLAST: a new
generation of protein database search programs&#34;, Nucleic
Acids Res. 25:3389-3402.


RID: 9RXNN4JV015


Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
           147,386,088 sequences; 54,027,546,203 total letters
Query= lcl|LISX01000001.1_cds_OKJ16671.1_31 [locus_tag=AMK19_00175]
[protein=penicillin-binding protein] [protein_id=OKJ16671.1]
[location=39730..41184]

Length=1455


                                                                   Score     E
Sequences producing significant alignments:                       (Bits)  Value

WP_073807071.1  penicillin-binding protein 2 [Kitasatospora sp...  996     0.0   
WP_035864460.1  penicillin-binding protein [Kitasatospora chee...  946     0.0   
WP_043915377.1  penicillin-binding protein 2 [Kitasatospora gr...  897     0.0   
WP_100589593.1  penicillin-binding protein [Kitasatospora sp. ...  896     0.0   
WP_014137042.1  penicillin-binding protein 2 [Kitasatospora se...  855     0.0   
WP_033254180.1  penicillin-binding protein 2 [Kitasatospora ph...  853     0.0   
WP_033214154.1  penicillin-binding protein 2 [Kitasatospora ph...  847     0.0   
WP_030457661.1  penicillin-binding protein 2 [Kitasatospora sp...  832     0.0   
WP_033820252.1  penicillin-binding protein 2 [Kitasatospora sp...  820     0.0   
WP_100889221.1  penicillin-binding protein 2 [Kitasatospora sp...  770     0.0   
WP_049656873.1  penicillin-binding protein 2 [Kitasatospora sp...  766     0.0   
AUG78584.1  penicillin-binding protein [Kitasatospora sp. MMS1...  764     0.0   
WP_057228636.1  MULTISPECIES: penicillin-binding protein 2 [Ki...  764     0.0   
WP_030392400.1  MULTISPECIES: penicillin-binding protein 2 [Ki...  736     0.0   
WP_030278231.1  MULTISPECIES: penicillin-binding protein 2 [St...  725     0.0   
WP_033346841.1  penicillin-binding protein 2 [Kitasatospora au...  724     0.0   
WP_035799332.1  penicillin-binding protein [Kitasatospora medi...  712     0.0   
WP_035847202.1  penicillin-binding protein [Kitasatospora azat...  704     0.0   
WP_084747517.1  penicillin-binding protein [Kitasatospora albo...  548     0.0   
WP_003978842.1  MULTISPECIES: penicillin-binding protein [Stre...  541     0.0   
WP_052836711.1  penicillin-binding protein 2 [Kitasatospora au...  516     1e-180
WP_003985178.1  MULTISPECIES: penicillin-binding protein [Stre...  514     1e-179
WP_052841852.1  penicillin-binding protein 2 [Kitasatospora au...  491     7e-171
WP_084745269.1  penicillin-binding protein [Kitasatospora albo...  481     7e-167
WP_051969980.1  penicillin-binding protein [Kitasatospora azat...  461     1e-158
WP_030393477.1  MULTISPECIES: penicillin-binding protein [Kita...  447     1e-153
WP_051966736.1  penicillin-binding protein [Kitasatospora medi...  446     1e-152
AUG79326.1  Putative penicillin-binding protein A [Kitasatospo...  445     4e-152
AUG79205.1  penicillin-binding protein [Kitasatospora sp. MMS1...  441     3e-151
WP_084746985.1  penicillin-binding protein 2 [Kitasatospora al...  440     1e-150
WP_003981922.1  MULTISPECIES: penicillin-binding protein 2 [St...  439     2e-150
WP_052836864.1  penicillin-binding protein 2 [Kitasatospora au...  436     4e-149
WP_078656350.1  penicillin-binding protein [Kitasatospora aure...  435     1e-148
OEV33654.1  penicillin-binding protein [Kitasatospora aureofac...  432     1e-147
WP_078938872.1  MULTISPECIES: penicillin-binding protein [Stre...  432     1e-147
BAJ30397.1  putative penicillin-binding protein A [Kitasatospo...  431     6e-147
WP_057228032.1  MULTISPECIES: penicillin-binding protein [Kita...  420     4e-143
WP_051055920.1  penicillin-binding protein [Kitasatospora setae]   420     5e-143
WP_033819927.1  penicillin-binding protein [Kitasatospora sp. ...  419     1e-142
WP_051817654.1  penicillin-binding protein [Kitasatospora sp. ...  413     2e-140
WP_051776935.1  penicillin-binding protein [Kitasatospora phos...  412     5e-140
WP_052840719.1  penicillin-binding protein [Kitasatospora aure...  412     1e-139
WP_051732513.1  penicillin-binding protein [Kitasatospora phos...  410     5e-139
WP_100892658.1  penicillin-binding protein [Kitasatospora sp. ...  408     4e-138
PKB48172.1  peptidoglycan glycosyltransferase [Kitasatospora s...  408     9e-138
WP_082346127.1  penicillin-binding protein [Kitasatospora sp. ...  406     5e-137
WP_003983996.1  MULTISPECIES: penicillin-binding protein [Stre...  395     4e-133
WP_083646743.1  penicillin-binding protein [Kitasatospora sp. ...  395     6e-133
KIQ64169.1  penicillin-binding protein [Kitasatospora griseola]    389     1e-130
KDN83954.1  penicillin-binding protein [Kitasatospora cheerisa...  387     8e-130

ALIGNMENTS
&gt;WP_073807071.1 penicillin-binding protein 2 [Kitasatospora sp. CB01950]
 OKJ16671.1 penicillin-binding protein [Kitasatospora sp. CB01950]
Length=484

 Score = 996 bits (2574),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 483/484 (99%), Positives = 484/484 (100%), Gaps = 0/484 (0%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ
Sbjct  1     MNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
             AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN
Sbjct  61    AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG
Sbjct  121   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  180

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
             TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT
Sbjct  181   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  240

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
             DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF
Sbjct  241   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  300

Query  901   GFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPY  1080
             GFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPY
Sbjct  301   GFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPY  360

Query  1081  LVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTG  1260
             LVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTG
Sbjct  361   LVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTG  420

Query  1261  TAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQA  1440
             TAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQA
Sbjct  421   TAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQA  480

Query  1441  ALGK  1452
             ALGK
Sbjct  481   ALGK  484


&gt;WP_035864460.1 penicillin-binding protein [Kitasatospora cheerisanensis]
 KDN84196.1 penicillin-binding protein [Kitasatospora cheerisanensis KCTC 
2395]
Length=484

 Score = 946 bits (2444),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 454/484 (94%), Positives = 471/484 (97%), Gaps = 0/484 (0%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKPIRRVSIFCLVLILALMLRVNWVQGVQAS WANNPHNDR KYD+YAYPRGNIIVGGQ
Sbjct  1     MNKPIRRVSIFCLVLILALMLRVNWVQGVQASDWANNPHNDRAKYDRYAYPRGNIIVGGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
             AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN
Sbjct  61    AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLG+KKGAAVAIDP+TGAILGLVSTPSYDP 
Sbjct  121   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGDKKGAAVAIDPRTGAILGLVSTPSYDPS  180

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
             TFAGGT +D KAWTAL++DPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQ P+D T
Sbjct  181   TFAGGTDEDGKAWTALNNDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQKPTDAT  240

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
             DTPDQYILPGTSTPLINASPTEDCG+ATVQHAMDLSCNTVFGKMGAELGGD LRAQAEKF
Sbjct  241   DTPDQYILPGTSTPLINASPTEDCGDATVQHAMDLSCNTVFGKMGAELGGDALRAQAEKF  300

Query  901   GFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPY  1080
             GFNKEV IP+RADASHFPS SKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPY
Sbjct  301   GFNKEVNIPVRADASHFPSNSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPY  360

Query  1081  LVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTG  1260
             LVAQEGSAGNVISTHTE QLSQAV+PATAQKLQQLMESVVQ+GTG NA+IPGVTVGGKTG
Sbjct  361   LVAQEGSAGNVISTHTERQLSQAVTPATAQKLQQLMESVVQNGTGKNARIPGVTVGGKTG  420

Query  1261  TAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQA  1440
             TAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDG+ E+++ISGGSLAAPIAKAMMQA
Sbjct  421   TAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGAGESREISGGSLAAPIAKAMMQA  480

Query  1441  ALGK  1452
             ALGK
Sbjct  481   ALGK  484


&gt;WP_043915377.1 penicillin-binding protein 2 [Kitasatospora griseola]
 KIQ63037.1 penicillin-binding protein [Kitasatospora griseola]
Length=485

 Score = 897 bits (2318),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 436/485 (90%), Positives = 454/485 (94%), Gaps = 1/485 (0%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKPIRRVSIFCLVLILALMLRVNWVQGVQAS WANNPHNDRTKYD+YAYPRGNII GGQ
Sbjct  1     MNKPIRRVSIFCLVLILALMLRVNWVQGVQASAWANNPHNDRTKYDRYAYPRGNIIAGGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
             AVT+SDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSG DSRLFFRN
Sbjct  61    AVTRSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGADSRLFFRN  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLG+KKGAAVA+DP+TGAILGLVSTPSYDPG
Sbjct  121   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGDKKGAAVALDPRTGAILGLVSTPSYDPG  180

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
             TF+GGTKDDE AW AL+ DPNKP+LNRALRETYPPGSTFKLVTAATAFE GKYQ P+D T
Sbjct  181   TFSGGTKDDENAWKALNDDPNKPLLNRALRETYPPGSTFKLVTAATAFENGKYQKPTDTT  240

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
             DTP+ Y+LPGTST L NAS TE C NATVQ AMD SCNTVFGKMGAELGGDKLRAQAEKF
Sbjct  241   DTPNPYVLPGTSTALRNASATEPCENATVQVAMDYSCNTVFGKMGAELGGDKLRAQAEKF  300

Query  901   GFNK-EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  1077
             GFN  ++ IPI    S+FP  SKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP
Sbjct  301   GFNSDQLRIPIAPTPSYFPKDSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  360

Query  1078  YLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKT  1257
             YLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQ+GTGT AKIPG TVGGKT
Sbjct  361   YLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQNGTGTKAKIPGATVGGKT  420

Query  1258  GTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQ  1437
             GTAQHGQDN+GLPFAWFVSYAKGQDGKQVAVAVVVEDG SE  +ISGGSLAAPIAKAMMQ
Sbjct  421   GTAQHGQDNAGLPFAWFVSYAKGQDGKQVAVAVVVEDGDSERNEISGGSLAAPIAKAMMQ  480

Query  1438  AALGK  1452
             AALGK
Sbjct  481   AALGK  485


&gt;WP_100589593.1 penicillin-binding protein [Kitasatospora sp. CB02891]
 PJN21785.1 penicillin-binding protein [Kitasatospora sp. CB02891]
Length=485

 Score = 896 bits (2315),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 436/485 (90%), Positives = 453/485 (93%), Gaps = 1/485 (0%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKPIRRVSIFCLVLILALMLRVNWVQGVQAS WANNPHNDRTKYD+YAYPRGNII GGQ
Sbjct  1     MNKPIRRVSIFCLVLILALMLRVNWVQGVQASAWANNPHNDRTKYDRYAYPRGNIIAGGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
             AVT+SDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSG DSRLFFRN
Sbjct  61    AVTRSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGADSRLFFRN  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLG+KKGAAVAIDP+TGAILGLVSTPSYDPG
Sbjct  121   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGDKKGAAVAIDPRTGAILGLVSTPSYDPG  180

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
             TF+GGTKDDE AW AL+ DPNKP+LNRALRETYPPGSTFKLVTAA AFE GKYQ P+D T
Sbjct  181   TFSGGTKDDENAWKALNDDPNKPLLNRALRETYPPGSTFKLVTAAAAFENGKYQKPTDTT  240

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
             DTP+ Y+LPGTST L NAS TE C NATVQ AMD SCNTVFGKMGAELGGDKLRAQAEKF
Sbjct  241   DTPNPYVLPGTSTALRNASATEPCENATVQVAMDYSCNTVFGKMGAELGGDKLRAQAEKF  300

Query  901   GFNK-EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  1077
             GFN  ++ IPI    S+FP  SKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP
Sbjct  301   GFNSDQLRIPIAPTPSYFPKDSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  360

Query  1078  YLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKT  1257
             YLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQ+GTGT AKIPG TVGGKT
Sbjct  361   YLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQNGTGTKAKIPGATVGGKT  420

Query  1258  GTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQ  1437
             GTAQHGQDN+GLPFAWFVSYAKGQDGKQVAVAVVVEDG SE  +ISGGSLAAPIAKAMMQ
Sbjct  421   GTAQHGQDNAGLPFAWFVSYAKGQDGKQVAVAVVVEDGDSERNEISGGSLAAPIAKAMMQ  480

Query  1438  AALGK  1452
             AALGK
Sbjct  481   AALGK  485


&gt;WP_014137042.1 penicillin-binding protein 2 [Kitasatospora setae]
 BAJ29737.1 putative penicillin-binding protein A [Kitasatospora setae KM-6054]
Length=485

 Score = 855 bits (2209),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 409/485 (84%), Positives = 448/485 (92%), Gaps = 1/485 (0%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKPIRRVSIFCLVLILALM+RVNWVQGVQA+ WANN HN+R KYD+YAYPRGNIIVGGQ
Sbjct  1     MNKPIRRVSIFCLVLILALMVRVNWVQGVQAAAWANNTHNERVKYDRYAYPRGNIIVGGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
              VTKSDFVNGLRYKYKRSWV+GP+YAPVTGYSSQ +DASQLEKLEDG+LSGTDSRLFFRN
Sbjct  61    PVTKSDFVNGLRYKYKRSWVEGPLYAPVTGYSSQIFDASQLEKLEDGVLSGTDSRLFFRN  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGN+KGAAVAIDP+TGAIL +VSTPSYDPG
Sbjct  121   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNRKGAAVAIDPRTGAILAVVSTPSYDPG  180

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
             TF+GGT  D  A+ AL  DPN+P++NRALRETYPPGSTFKL+TAATAFETGKYQ+P+D T
Sbjct  181   TFSGGTDADSAAYKALQDDPNRPLVNRALRETYPPGSTFKLITAATAFETGKYQNPNDTT  240

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
              TP+ Y+LPGT+TPL NAS TE C +ATV  AMD SCNTVFGKMGAELG D+LRAQAEKF
Sbjct  241   QTPNPYVLPGTNTPLRNASATEPCEDATVMVAMDYSCNTVFGKMGAELGRDQLRAQAEKF  300

Query  901   GFNKE-VTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  1077
             GFN + V IPIRA AS++PSGS PDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLM+P
Sbjct  301   GFNNDKVDIPIRATASYYPSGSSPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMQP  360

Query  1078  YLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKT  1257
             YLVAQEG+AGN ISTH+EHQ+SQAVSPATAQKLQQLMESVVQ+GTG  A IPG+TVGGKT
Sbjct  361   YLVAQEGAAGNAISTHSEHQMSQAVSPATAQKLQQLMESVVQNGTGKKAAIPGLTVGGKT  420

Query  1258  GTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQ  1437
             GTAQHGQDNSGLPFAWFVSYAK   GKQVAVAVVVEDG++E+ +ISGGSLAAPIAK+MMQ
Sbjct  421   GTAQHGQDNSGLPFAWFVSYAKDASGKQVAVAVVVEDGAAESAEISGGSLAAPIAKSMMQ  480

Query  1438  AALGK  1452
             AALGK
Sbjct  481   AALGK  485


&gt;WP_033254180.1 penicillin-binding protein 2 [Kitasatospora phosalacinea]
Length=485

 Score = 853 bits (2203),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 409/485 (84%), Positives = 445/485 (92%), Gaps = 1/485 (0%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKPIRRVSIFCLVLILAL++RVNWVQGVQAS WANN  N+RTKYD+YAYPRGNIIVGGQ
Sbjct  1     MNKPIRRVSIFCLVLILALLVRVNWVQGVQASAWANNKENERTKYDRYAYPRGNIIVGGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
              VTKSDFVNGLRYKYKR+WVDGPMYAPVTGYSSQ YDASQLEKLEDG+LSGTDSRLFFRN
Sbjct  61    PVTKSDFVNGLRYKYKRAWVDGPMYAPVTGYSSQIYDASQLEKLEDGVLSGTDSRLFFRN  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGN+KGAAVAIDP TGAIL LVSTPSYDPG
Sbjct  121   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNRKGAAVAIDPNTGAILALVSTPSYDPG  180

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
             TFAGGT  D  A+ AL +DPN+PMLNRALR+TYPPGSTFKLVTAATAFETGKY+ P D T
Sbjct  181   TFAGGTDADSAAYNALKADPNQPMLNRALRQTYPPGSTFKLVTAATAFETGKYKDPGDAT  240

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
             +TP+ YILPGTSTPLIN SP EDC NAT+  A+ +SCNTVFGK+GAELGGD LRAQAEKF
Sbjct  241   ETPETYILPGTSTPLINDSPDEDCENATLTSALAISCNTVFGKLGAELGGDALRAQAEKF  300

Query  901   GFNKE-VTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  1077
             GFN + V IP+RA AS++PSGS PDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLM+P
Sbjct  301   GFNDDKVDIPVRAAASYYPSGSSPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMQP  360

Query  1078  YLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKT  1257
             YLV+QEG+ G+ ISTH+EHQ+SQAVSPATAQKLQQ+ME VV+ GTG  AKIPGVTVGGKT
Sbjct  361   YLVSQEGAPGHAISTHSEHQMSQAVSPATAQKLQQMMEEVVKSGTGKRAKIPGVTVGGKT  420

Query  1258  GTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQ  1437
             GTAQHGQDNSG PFAWFVSYAK   GKQVAVAVVVEDG++++ +ISGGSLAAPIAKAMMQ
Sbjct  421   GTAQHGQDNSGKPFAWFVSYAKDSGGKQVAVAVVVEDGAAQSAEISGGSLAAPIAKAMMQ  480

Query  1438  AALGK  1452
             AALGK
Sbjct  481   AALGK  485


&gt;WP_033214154.1 penicillin-binding protein 2 [Kitasatospora phosalacinea]
Length=485

 Score = 847 bits (2188),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 405/485 (84%), Positives = 446/485 (92%), Gaps = 1/485 (0%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKPIRRVSIFCLVLILALM+RVNWVQGVQAS WA+NPHN+RTKYD+YAYPRGNIIVGGQ
Sbjct  1     MNKPIRRVSIFCLVLILALMVRVNWVQGVQASAWASNPHNERTKYDRYAYPRGNIIVGGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
              VTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQ +DASQLEKLED +LSGTDSRLFFRN
Sbjct  61    PVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQVFDASQLEKLEDDVLSGTDSRLFFRN  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             TLDMLTGK +QGGDVVTTIDPKVQKAGFEGLGN+KGAAVAIDP+TGAIL LVSTPSYDPG
Sbjct  121   TLDMLTGKTRQGGDVVTTIDPKVQKAGFEGLGNRKGAAVAIDPRTGAILALVSTPSYDPG  180

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
             TFAGG+  D  AWTAL SDPN+PMLNRALR+TYPPGSTFKLVTAATAFETGK++ P+D T
Sbjct  181   TFAGGSDADSAAWTALKSDPNQPMLNRALRQTYPPGSTFKLVTAATAFETGKFKDPNDET  240

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
              TP+ YILPGTSTPL+N SP E C +AT+  AM LSCNTVFGK+GAELGGD +RAQAEKF
Sbjct  241   QTPETYILPGTSTPLVNDSPDEPCTDATLAAAMALSCNTVFGKIGAELGGDAVRAQAEKF  300

Query  901   GFNKE-VTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  1077
             GFN + V +PIRA AS++PSGS PDGTAMDAIGQHDTRATPL+MAMVAAAIANNGSLM+P
Sbjct  301   GFNNDKVDVPIRAAASYYPSGSSPDGTAMDAIGQHDTRATPLEMAMVAAAIANNGSLMQP  360

Query  1078  YLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKT  1257
             YLVAQEG+ G+ ISTH+EHQ+SQAVSPATAQKLQQLME VV++GTG  A IPGVTVGGKT
Sbjct  361   YLVAQEGAPGHAISTHSEHQMSQAVSPATAQKLQQLMEGVVKNGTGQRANIPGVTVGGKT  420

Query  1258  GTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQ  1437
             GTAQHGQDN+G PFAWFVSYAK   GKQVAVAVVVEDG++++ +ISGGSLAAPIAK+MMQ
Sbjct  421   GTAQHGQDNAGKPFAWFVSYAKDSSGKQVAVAVVVEDGAAQSSEISGGSLAAPIAKSMMQ  480

Query  1438  AALGK  1452
             AALGK
Sbjct  481   AALGK  485


&gt;WP_030457661.1 penicillin-binding protein 2 [Kitasatospora sp. NRRL B-11411]
Length=485

 Score = 832 bits (2150),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 407/485 (84%), Positives = 444/485 (92%), Gaps = 1/485 (0%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKPIRRVSIFCLVL+LALM+RVNWVQGVQAS WA NPHNDR KYD+YAYPRGNIIVGGQ
Sbjct  1     MNKPIRRVSIFCLVLVLALMVRVNWVQGVQASAWAGNPHNDRVKYDRYAYPRGNIIVGGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
              VTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQ YDASQLEKLED +LSGTDSRLFFRN
Sbjct  61    PVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQIYDASQLEKLEDPVLSGTDSRLFFRN  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGN+KGAAVAIDP+TGAIL LVSTPSYDP 
Sbjct  121   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNRKGAAVAIDPRTGAILALVSTPSYDPS  180

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
             TFAGG   D  AWTAL +DPN+PMLNRALR+TYPPGSTFKLVTAATAFETGK+++P+D T
Sbjct  181   TFAGGGDSDSAAWTALQNDPNQPMLNRALRQTYPPGSTFKLVTAATAFETGKFKNPTDTT  240

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
             DTP+ YILPGTSTPL+N SP E C NAT+  AM +SCNTVFGK+GAELG D LR+QAEKF
Sbjct  241   DTPETYILPGTSTPLVNDSPDEPCTNATLASAMAISCNTVFGKIGAELGKDALRSQAEKF  300

Query  901   GFNKE-VTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  1077
             GFN + V +PIRA AS++PSGS PDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLM+P
Sbjct  301   GFNNDKVDVPIRAAASYYPSGSSPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMQP  360

Query  1078  YLVAQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKT  1257
             YLV+QEGSAGN ISTH+EHQLSQAVSP TAQKLQQLME+VV+ GTG  A IPGVTVGGKT
Sbjct  361   YLVSQEGSAGNAISTHSEHQLSQAVSPDTAQKLQQLMEAVVKDGTGRRAAIPGVTVGGKT  420

Query  1258  GTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQ  1437
             GTAQHGQDN+G PFAWFVSYAK   GKQVAVAVVVEDG++++ +ISGGS+AAPIAK+MMQ
Sbjct  421   GTAQHGQDNAGKPFAWFVSYAKDSGGKQVAVAVVVEDGAAQSSEISGGSIAAPIAKSMMQ  480

Query  1438  AALGK  1452
             AALGK
Sbjct  481   AALGK  485


&gt;WP_033820252.1 penicillin-binding protein 2 [Kitasatospora sp. MBT63]
Length=486

 Score = 820 bits (2117),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 393/486 (81%), Positives = 435/486 (90%), Gaps = 2/486 (0%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKPIRRVSIFCLVLILALM+RVNWVQGVQA  WA+N HNDR KYD+YAYPRGNII GGQ
Sbjct  1     MNKPIRRVSIFCLVLILALMVRVNWVQGVQAEAWASNKHNDRNKYDRYAYPRGNIIAGGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
              VT SDFVNGLRYKYKRSW+DGPMYAP+TGYSSQ++  SQLE+LEDG+L+GTDSRLFFRN
Sbjct  61    PVTNSDFVNGLRYKYKRSWIDGPMYAPITGYSSQSFGTSQLEQLEDGVLAGTDSRLFFRN  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             TLDMLTG+ K+GGDVVTTIDPK QKA FEGLG+KKGAAVAIDP+TGAIL LVSTPSYDPG
Sbjct  121   TLDMLTGEQKKGGDVVTTIDPKAQKAAFEGLGDKKGAAVAIDPRTGAILALVSTPSYDPG  180

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
             TF+GG K+D KAWT L++DPNKPMLNRALRETYPPGSTFKL+TAATAFETG Y++  D T
Sbjct  181   TFSGGGKEDSKAWTDLNNDPNKPMLNRALRETYPPGSTFKLITAATAFETGLYKNVDDAT  240

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
              TP  +ILPGT+T L NAS TEDC NATV+H MDLSCNTVFGKMGA+LG D+LRAQAEKF
Sbjct  241   QTPKPFILPGTNTELKNASATEDCENATVEHGMDLSCNTVFGKMGADLGKDRLRAQAEKF  300

Query  901   GFNK-EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  1077
             GFN  ++  PIRA  S FPS S PDGTAMDAIGQHDTRATPLQMAMVAAAI NNGSLM+P
Sbjct  301   GFNNGKIDTPIRAVTSVFPSNSSPDGTAMDAIGQHDTRATPLQMAMVAAAICNNGSLMQP  360

Query  1078  YLVAQEGSAG-NVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGK  1254
             YL+AQE SA  +VIS HTEHQLSQAVSPATAQKLQQLMESVVQ+GTGT AKI G TVGGK
Sbjct  361   YLIAQERSANLDVISNHTEHQLSQAVSPATAQKLQQLMESVVQNGTGTKAKINGATVGGK  420

Query  1255  TGTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMM  1434
             TGTAQHGQDNSGLPFAWF+SYAKG DGKQVAVAVVVEDG++E  +ISGGS+AAPIAK++M
Sbjct  421   TGTAQHGQDNSGLPFAWFMSYAKGADGKQVAVAVVVEDGAAERNEISGGSIAAPIAKSVM  480

Query  1435  QAALGK  1452
             +A + K
Sbjct  481   EAVVNK  486


&gt;WP_100889221.1 penicillin-binding protein 2 [Kitasatospora sp. OK780]
 PKB48640.1 peptidoglycan glycosyltransferase [Kitasatospora sp. OK780]
Length=486

 Score = 770 bits (1989),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 382/485 (79%), Positives = 427/485 (88%), Gaps = 4/485 (1%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKPIRRVS+FCLVL+LAL++R NWVQGVQA  WA+N HNDR KYD+YAYPRGNIIVGGQ
Sbjct  1     MNKPIRRVSVFCLVLVLALLVRTNWVQGVQAQAWASNQHNDRNKYDRYAYPRGNIIVGGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
              VT SDFVNGLRYKYKRSWVDGPMYAPVTGYSSQ++  SQLE LEDGIL+GTDSRLFFRN
Sbjct  61    PVTNSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQSFGTSQLESLEDGILAGTDSRLFFRN  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             TLDMLTG  K+GG+VVTTI+ K QKA FEGLGNKKGAAVAIDP+TGAIL LVSTPSYDPG
Sbjct  121   TLDMLTGGDKKGGNVVTTINAKAQKAAFEGLGNKKGAAVAIDPRTGAILALVSTPSYDPG  180

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
             TF+G T  D KAWT L++DPNKPMLNRALRETYPPGSTFKL+TAA AFETG +Q+P D T
Sbjct  181   TFSGSTAADAKAWTDLNADPNKPMLNRALRETYPPGSTFKLITAAAAFETGMFQNPEDKT  240

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
             +TP+ Y LPGT T L NAS TE C NAT+   MD SCNTVFGK+GA+LG DKLRAQAEKF
Sbjct  241   ETPNPYTLPGTKTVLKNASETEPCENATLLVGMDFSCNTVFGKIGADLGKDKLRAQAEKF  300

Query  901   GFNK-EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  1077
             GFN  +V +PIR   S FP+ S PDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLM+P
Sbjct  301   GFNNSQVDVPIRPSTSVFPTNSSPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMQP  360

Query  1078  YLVAQEGSAGN--VISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGG  1251
             YLV QE  AGN  V+S H+E QLSQAVSPATAQKLQQLMESVV++GTGT A+I GVTVGG
Sbjct  361   YLVDQE-QAGNLAVVSKHSEKQLSQAVSPATAQKLQQLMESVVKNGTGTKAQIDGVTVGG  419

Query  1252  KTGTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAM  1431
             KTGTAQHGQDNSGLPFAWF+SYAKG DGKQVAVAVVVEDG++E+++ISGGS+AAPIAK++
Sbjct  420   KTGTAQHGQDNSGLPFAWFMSYAKGADGKQVAVAVVVEDGAAESREISGGSIAAPIAKSV  479

Query  1432  MQAAL  1446
             M+A +
Sbjct  480   MEAVV  484


&gt;WP_049656873.1 penicillin-binding protein 2 [Kitasatospora sp. MY 5-36]
Length=485

 Score = 766 bits (1977),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 369/485 (76%), Positives = 412/485 (85%), Gaps = 1/485 (0%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKPIRRVSIFCLVLILALM+R NWVQGVQA +WA N +N R  YD+YA+PRGNIIV GQ
Sbjct  1     MNKPIRRVSIFCLVLILALMVRTNWVQGVQADSWATNKNNKRQLYDRYAHPRGNIIVSGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
              VTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQ Y +SQLE LEDGILSGTD RLFFRN
Sbjct  61    PVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQAYGSSQLENLEDGILSGTDDRLFFRN  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             TLDMLTG+ K+GGDVVTTI+ KVQKA F+ +GNKKGA VA+DPKTGAILGLVSTPSYDPG
Sbjct  121   TLDMLTGEQKRGGDVVTTINAKVQKAAFDAMGNKKGAVVALDPKTGAILGLVSTPSYDPG  180

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
             TFAGG   D KAWT L++DPNKPMLNRAL+ETYPPGSTFKLVTA  AFE G+YQS  D T
Sbjct  181   TFAGGEAADTKAWTDLNADPNKPMLNRALKETYPPGSTFKLVTATAAFENGRYQSIDDAT  240

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
             DTPD ++LPGT+T L N SP E C NATV+  MD SCNTVF KMGA+LG +++RAQAEKF
Sbjct  241   DTPDPWVLPGTTTQLKNESPNERCENATVKSGMDQSCNTVFAKMGADLGKERMRAQAEKF  300

Query  901   GFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPY  1080
             GFN  +  P+R++ S FP  S PDGTA D+IGQHDTRATPLQMAMV+AAIANNGSLM+PY
Sbjct  301   GFNSTIDTPVRSEKSVFPDSSSPDGTAQDSIGQHDTRATPLQMAMVSAAIANNGSLMQPY  360

Query  1081  LVAQEGSAG-NVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKT  1257
             LV QE SA    +S HTE Q SQA+SPATAQK+Q LM SVV++GTGTNAKIPG+ VGGKT
Sbjct  361   LVDQERSATLTTVSKHTEKQFSQAMSPATAQKMQDLMVSVVENGTGTNAKIPGLQVGGKT  420

Query  1258  GTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQ  1437
             GTAQHG+DN+GLPFAWF S+AK  DG+ VAVAVVVEDGS     ISGG LAAPIAKA+MQ
Sbjct  421   GTAQHGEDNAGLPFAWFTSWAKTPDGQSVAVAVVVEDGSQNRDGISGGRLAAPIAKAVMQ  480

Query  1438  AALGK  1452
             AALGK
Sbjct  481   AALGK  485


&gt;AUG78584.1 penicillin-binding protein [Kitasatospora sp. MMS16-BH015]
Length=485

 Score = 764 bits (1974),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 377/484 (78%), Positives = 412/484 (85%), Gaps = 2/484 (0%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKPIRRVS+FCLVLILALM+R NWVQGVQA TWA+N HNDR KYD+YAYPRGNIIV G 
Sbjct  1     MNKPIRRVSVFCLVLILALMVRTNWVQGVQADTWASNSHNDRNKYDRYAYPRGNIIVQGN  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
              VTKSDFVNGLRYKYK+SWVDGPMYAPVTG+SSQ +D+SQLEKLED ILSGTDSRLF RN
Sbjct  61    PVTKSDFVNGLRYKYKQSWVDGPMYAPVTGWSSQAFDSSQLEKLEDPILSGTDSRLFLRN  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             TLDMLTGK KQGGDVVTTI+ K QKA FEGLG+KKGAAVAIDP TGAIL LVSTPSYDP 
Sbjct  121   TLDMLTGKQKQGGDVVTTINAKAQKAAFEGLGDKKGAAVAIDPATGAILALVSTPSYDPS  180

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
             TFAGG   D  A  ALD DPN+P+LNRALRETYPPGSTFKL+TAA AFE G++QS  D T
Sbjct  181   TFAGGATADGNAKAALDKDPNQPLLNRALRETYPPGSTFKLITAAAAFENGRFQSIDDTT  240

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
             DTP  YILPGT+T L NAS TE C NATV+  MD SCNTVFGK+GA+LG DKLR QAEKF
Sbjct  241   DTPAHYILPGTNTELKNASDTEPCPNATVKTGMDFSCNTVFGKIGADLGKDKLRGQAEKF  300

Query  901   GFNK-EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  1077
             GFN   +  PIRA  S+FP  S PDGTAMDAIGQHDTRATPLQMAMVA+AI NNGSLM P
Sbjct  301   GFNNPALDTPIRAVPSYFPPNSSPDGTAMDAIGQHDTRATPLQMAMVASAICNNGSLMTP  360

Query  1078  YLVAQEGSAG-NVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGK  1254
             YLV QE SA   VIS HT  QLSQAVSP TAQKLQQLMESVV +GTGT A+I G+TVGGK
Sbjct  361   YLVEQERSANLTVISKHTPKQLSQAVSPGTAQKLQQLMESVVANGTGTKAQIDGLTVGGK  420

Query  1255  TGTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMM  1434
             TGTAQHGQDN+GLPFAWF+SYAKG D K VAVAVVVEDG++E  +ISGGS+AAPIAK++M
Sbjct  421   TGTAQHGQDNAGLPFAWFMSYAKGPDNKSVAVAVVVEDGAAERNEISGGSIAAPIAKSVM  480

Query  1435  QAAL  1446
             +A L
Sbjct  481   EAVL  484


&gt;WP_057228636.1 MULTISPECIES: penicillin-binding protein 2 [Kitasatospora]
 KQV22225.1 penicillin-binding protein [Kitasatospora sp. Root107]
 KRB64622.1 penicillin-binding protein [Kitasatospora sp. Root187]
Length=487

 Score = 764 bits (1973),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 366/487 (75%), Positives = 419/487 (86%), Gaps = 3/487 (1%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIV-GG  177
             +NKPIRRVSIFCLVL+LALM+RVNWVQGVQA  WA+NPHNDR KYD+YAYPRGNIIV GG
Sbjct  1     MNKPIRRVSIFCLVLVLALMVRVNWVQGVQAEAWASNPHNDRNKYDRYAYPRGNIIVAGG  60

Query  178   QAVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFR  357
             Q +T+SDFVNG RYKYKR+WVDGP++APVTGYSSQ Y  SQLE L DGILSG+DSRLFFR
Sbjct  61    QPITRSDFVNGYRYKYKRAWVDGPLWAPVTGYSSQAYTTSQLESLSDGILSGSDSRLFFR  120

Query  358   NTLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDP  537
             NTLDMLTGK KQGGDVVTT++ K QKA ++ LG+KKGAAVAIDP+TGAIL LVSTPSYDP
Sbjct  121   NTLDMLTGKEKQGGDVVTTLNAKAQKAAYDALGSKKGAAVAIDPRTGAILALVSTPSYDP  180

Query  538   GTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDV  717
             G FAG   +DEKAW  L++DPNKPMLNRALRETYPPGSTFKLVTAA AFE+G+YQ+  DV
Sbjct  181   GRFAGTGAEDEKAWNELNADPNKPMLNRALRETYPPGSTFKLVTAAAAFESGRYQNIEDV  240

Query  718   TDTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEK  897
             TDTP +Y+LP T+  L NAS  E C NAT++ AMD SCNTVFGK+GA+LGG+K+R QAE+
Sbjct  241   TDTPQRYVLPNTNVELKNASDDEPCANATLKVAMDYSCNTVFGKIGADLGGEKMRTQAER  300

Query  898   FGFNKE-VTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLME  1074
             FGFN   + +PIRA  S FPS S  DGTAMD+IGQHDTRATPLQMAMVAAAIAN+G LM 
Sbjct  301   FGFNNPGINVPIRASESFFPSKSSADGTAMDSIGQHDTRATPLQMAMVAAAIANDGRLMA  360

Query  1075  PYLVAQEGSAG-NVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGG  1251
             PY+V +E ++    IS H+E QLSQAVSPATAQKLQQLMESVVQ+GTG  A+I G+ VGG
Sbjct  361   PYMVDEERASNLTTISKHSERQLSQAVSPATAQKLQQLMESVVQNGTGKKAQIDGLKVGG  420

Query  1252  KTGTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAM  1431
             KTGTAQHG++N+GLPFAWF+SYAK  DG+QVAVAVVVEDGSSE  QISGG LAAPIAKA+
Sbjct  421   KTGTAQHGENNAGLPFAWFMSYAKAPDGRQVAVAVVVEDGSSERDQISGGGLAAPIAKAL  480

Query  1432  MQAALGK  1452
             M+AAL +
Sbjct  481   MKAALDR  487


&gt;WP_030392400.1 MULTISPECIES: penicillin-binding protein 2 [Kitasatospora]
Length=485

 Score = 736 bits (1901),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 357/485 (74%), Positives = 401/485 (83%), Gaps = 1/485 (0%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKPIRRVSIFCLVLILALM+R NWVQGVQA  WA N +N R  YD+YAYPRGNIIV GQ
Sbjct  1     MNKPIRRVSIFCLVLILALMVRTNWVQGVQADAWAGNKYNKRQVYDRYAYPRGNIIVDGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
              +T+S FV+GLRYKYKRSW D  MYAPVTGYSSQ + ASQLE+LEDG+LSG+D RLFFRN
Sbjct  61    PITQSTFVDGLRYKYKRSWTDPQMYAPVTGYSSQAFGASQLEQLEDGVLSGSDDRLFFRN  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             TLDMLTG+ K+GGDVVTTI+ K QKA FEGLGNKKGA VA+DPKTGAIL LVSTPSYDP 
Sbjct  121   TLDMLTGEQKRGGDVVTTINSKAQKAAFEGLGNKKGAVVALDPKTGAILALVSTPSYDPA  180

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
             +FAG    D KAWT L++DPNKPMLNRALRETYPPGSTFKLVTA+ AFE G YQ+  D T
Sbjct  181   SFAGNESTDSKAWTDLNADPNKPMLNRALRETYPPGSTFKLVTASAAFENGLYQNIDDQT  240

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
              TPD Y LPGT+  L N S  E CGNAT++  MD SCNTVF K+GA+LG DK+R QAEKF
Sbjct  241   ATPDPYTLPGTNFVLKNESDREQCGNATIKSGMDQSCNTVFAKIGADLGKDKMRVQAEKF  300

Query  901   GFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPY  1080
             GFN  V  PIR++ S FPS S PDGTA D+IGQHDT+ATPLQMAMV+AAIANNGSLM+PY
Sbjct  301   GFNSTVDTPIRSEKSVFPSNSTPDGTAQDSIGQHDTQATPLQMAMVSAAIANNGSLMQPY  360

Query  1081  LVAQEGSAG-NVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKT  1257
             LVA+E SA    IS H+E Q SQ +SPATAQK+Q LM SVV++GTG NAKIPGVTVGGKT
Sbjct  361   LVAEERSASLTTISKHSEKQFSQPISPATAQKMQDLMVSVVENGTGKNAKIPGVTVGGKT  420

Query  1258  GTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQ  1437
             GTAQHG+ N+GLPFAWF SYAK  DG+ VAVAVVVEDGS+    ISGG LAAPIAK++MQ
Sbjct  421   GTAQHGEGNAGLPFAWFTSYAKASDGRTVAVAVVVEDGSNNRDGISGGRLAAPIAKSVMQ  480

Query  1438  AALGK  1452
             A LGK
Sbjct  481   AVLGK  485


&gt;WP_030278231.1 MULTISPECIES: penicillin-binding protein 2 [Streptomycetaceae]
 OEV37885.1 penicillin-binding protein [Kitasatospora aureofaciens]
 ARF79435.1 penicillin-binding protein [Kitasatospora aureofaciens]
Length=483

 Score = 725 bits (1872),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 355/485 (73%), Positives = 400/485 (82%), Gaps = 3/485 (1%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKPIRRVSIFCLVLILALM+R NWVQGVQA  WA+N +N R  YD+YA+PRGNIIV GQ
Sbjct  1     MNKPIRRVSIFCLVLILALMVRTNWVQGVQADAWASNKNNKRQLYDRYAHPRGNIIVSGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
              VT SDFVNGLRYKYKRSW++GPMYAPVTGYSSQ Y ++ LE LEDGILSGTD RLFFRN
Sbjct  61    PVTNSDFVNGLRYKYKRSWINGPMYAPVTGYSSQAYGSNGLENLEDGILSGTDDRLFFRN  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             TLDMLTG+ ++GGDVVTTI+ KVQKA F+ +G+KKGA VA+DPKTGAIL LVSTPSYDPG
Sbjct  121   TLDMLTGEQQRGGDVVTTINAKVQKAAFDAMGDKKGAVVALDPKTGAILALVSTPSYDPG  180

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
             T AG   DD  AW AL+SDPNKPM NRAL+ TYPPGSTFKLVTA  AFE G +QS  D T
Sbjct  181   TIAG--NDDGDAWKALNSDPNKPMDNRALKYTYPPGSTFKLVTATAAFENGMFQSIDDTT  238

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
              TP+ YILPGT TPL N SP E C NATV+  +D SCNTVF K+GA+LG DK+RAQAEKF
Sbjct  239   STPEPYILPGTQTPLKNESPNERCENATVKSGLDQSCNTVFAKIGADLGKDKMRAQAEKF  298

Query  901   GFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPY  1080
             GFN  +  P+RA+ S FP+ +  DGTA D+IGQHDTRATPLQ+AMV+AAIANNGSLM+PY
Sbjct  299   GFNSTIDTPVRAEKSVFPNSASLDGTAQDSIGQHDTRATPLQVAMVSAAIANNGSLMQPY  358

Query  1081  LVAQEGSAG-NVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKT  1257
             LV QE SA    IS HTE Q SQA+SPATAQK+Q LM SVVQ GTG NA+IPGV VGGKT
Sbjct  359   LVDQERSASLTTISKHTEKQFSQAMSPATAQKMQDLMVSVVQDGTGKNAQIPGVQVGGKT  418

Query  1258  GTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQ  1437
             GTAQHG++NS LP+AWF S+AK  DG+ VAVAVVVEDGS     ISGG LAAPIAKA+MQ
Sbjct  419   GTAQHGENNSALPYAWFTSWAKTPDGQSVAVAVVVEDGSDNRDGISGGRLAAPIAKAVMQ  478

Query  1438  AALGK  1452
             AALGK
Sbjct  479   AALGK  483


&gt;WP_033346841.1 penicillin-binding protein 2 [Kitasatospora aureofaciens]
Length=483

 Score = 724 bits (1870),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 354/485 (73%), Positives = 400/485 (82%), Gaps = 3/485 (1%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKPIRRVSIFCLVLILALM+R NWVQGVQA  WA+N +N R  YD+YA+PRGNIIV GQ
Sbjct  1     MNKPIRRVSIFCLVLILALMVRTNWVQGVQADAWASNKNNKRQLYDRYAHPRGNIIVSGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
              VT SDFVNGLRYKYKRSW++GPMYAPVTGYSSQ Y ++ LE LEDGILSGTD RLFFRN
Sbjct  61    PVTNSDFVNGLRYKYKRSWINGPMYAPVTGYSSQAYGSNGLENLEDGILSGTDDRLFFRN  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             TLDMLTG+ ++GGDVVTTI+ KVQKA F+ +G+KKGA VA+DPKTGAIL LVSTPSYDPG
Sbjct  121   TLDMLTGEQQRGGDVVTTINAKVQKAAFDAMGDKKGAVVALDPKTGAILALVSTPSYDPG  180

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
             T AG   DD  AW AL+SDPNKPM NRAL+ TYPPGSTFKLVTA  AFE G +QS  D T
Sbjct  181   TIAG--NDDGDAWKALNSDPNKPMDNRALKYTYPPGSTFKLVTATAAFENGMFQSIDDTT  238

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
              TP+ YILPGT TPL N SP E C NATV+  +D SCNTVF K+GA+LG DK+RAQAEKF
Sbjct  239   STPEPYILPGTQTPLKNESPNERCENATVKSGLDQSCNTVFAKIGADLGKDKMRAQAEKF  298

Query  901   GFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPY  1080
             GFN  +  P+RA+ S FP+ +  DGTA D+IGQHDTRATPLQ+AMV+AAIANNGSLM+PY
Sbjct  299   GFNSTIDTPVRAEKSVFPNSASLDGTAQDSIGQHDTRATPLQVAMVSAAIANNGSLMQPY  358

Query  1081  LVAQEGSAG-NVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKT  1257
             LV QE SA    +S HTE Q SQA+SPATAQK+Q LM SVVQ GTG NA+IPGV VGGKT
Sbjct  359   LVDQERSASLTTVSKHTEKQFSQAMSPATAQKMQDLMVSVVQDGTGKNAQIPGVQVGGKT  418

Query  1258  GTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQ  1437
             GTAQHG++NS LP+AWF S+AK  DG+ VAVAVVVEDGS     ISGG LAAPIAKA+MQ
Sbjct  419   GTAQHGENNSALPYAWFTSWAKTPDGQSVAVAVVVEDGSDNRDGISGGRLAAPIAKAVMQ  478

Query  1438  AALGK  1452
             AALGK
Sbjct  479   AALGK  483


&gt;WP_035799332.1 penicillin-binding protein [Kitasatospora mediocidica]
Length=483

 Score = 712 bits (1839),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 356/485 (73%), Positives = 411/485 (85%), Gaps = 3/485 (1%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKPIRRVS+FCL+LI+AL+LR NW+QGVQA ++AN+P+NDR KYD+YAYPRGNIIVGGQ
Sbjct  1     MNKPIRRVSVFCLILIMALLLRTNWIQGVQADSYANSPYNDRVKYDRYAYPRGNIIVGGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
              VT+S+FVNG RYKYK  W DG MYAPVTGYSSQ Y ++QLE+LED ILSGTD RLFFRN
Sbjct  61    PVTQSNFVNGYRYKYKTGWTDGAMYAPVTGYSSQAYGSNQLEQLEDPILSGTDDRLFFRN  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             TLDMLTGK KQGGDVVTTI+ K QKA F+GLG+KKGAAVAIDP+TGAIL LVSTPSYDP 
Sbjct  121   TLDMLTGKQKQGGDVVTTINAKAQKAAFDGLGDKKGAAVAIDPRTGAILALVSTPSYDPS  180

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
             T AG T  D+ AW +L++DPN+PMLNRALR+TYPPGSTFKLVTAATAFETGK+QSP D T
Sbjct  181   TIAGTT--DDTAWKSLNADPNQPMLNRALRQTYPPGSTFKLVTAATAFETGKFQSPDDQT  238

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
             DTP  Y LPGT+T L N SP E C NAT++ A+ +SCNTVFGK+GAELG  KL AQA+KF
Sbjct  239   DTPQTYTLPGTNTQLNNDSPDEPCTNATLKDALAISCNTVFGKIGAELGSQKLLAQADKF  298

Query  901   GFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPY  1080
             GFN  V  PIR+  S FP+ S PDGTAMDAIGQH+T ATPLQMAMVAAAIANNG LM+PY
Sbjct  299   GFNNTVDTPIRSAPSVFPNNSSPDGTAMDAIGQHNTAATPLQMAMVAAAIANNGKLMQPY  358

Query  1081  LVAQEGSAGN-VISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKT  1257
             LV +E SA +  IS HTEH++ QA+SPATAQKLQQ+M +VVQ GTG  A+I GV VGGKT
Sbjct  359   LVDEERSANSTTISKHTEHEMDQAISPATAQKLQQMMVAVVQDGTGKKAQINGVEVGGKT  418

Query  1258  GTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQ  1437
             GTAQHGQ NSGLPFAWFVSYAK  D   VAVAVVVEDG++ + +ISGGS+AAPIAK++MQ
Sbjct  419   GTAQHGQGNSGLPFAWFVSYAKVGDNAPVAVAVVVEDGAASSNEISGGSIAAPIAKSVMQ  478

Query  1438  AALGK  1452
             A +G+
Sbjct  479   AVIGQ  483


&gt;WP_035847202.1 penicillin-binding protein [Kitasatospora azatica]
Length=486

 Score = 704 bits (1817),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 342/486 (70%), Positives = 404/486 (83%), Gaps = 2/486 (0%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKPIRRVS+FC+VLI AL+LR NWVQGV A ++A NP+N RT YD+Y+YPRGNII GGQ
Sbjct  1     MNKPIRRVSVFCMVLIFALLLRTNWVQGVVADSYAENPNNRRTVYDQYSYPRGNIIAGGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQT-YDASQLEKLEDGILSGTDSRLFFR  357
              +T+SDF NG  YKYKR + DG MYAPVTG++SQ+ + ++ LE LE+G+L+GTD RLFFR
Sbjct  61    PITRSDFTNGYLYKYKRGYTDGAMYAPVTGFTSQSAFGSNGLENLENGVLAGTDDRLFFR  120

Query  358   NTLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDP  537
             N+LD LTGK ++GGDVVTTI+PKVQKA F+ L  KKGAAVA+DP+TGAIL LVSTPSYDP
Sbjct  121   NSLDALTGKQRKGGDVVTTINPKVQKAAFDALSGKKGAAVALDPRTGAILALVSTPSYDP  180

Query  538   GTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDV  717
              T AG +  D  AW AL++D N+PML+RALR+TYPPGSTFKLVTAATAFETGKYQ+P D 
Sbjct  181   NTIAGTSGADGDAWKALNADQNQPMLDRALRQTYPPGSTFKLVTAATAFETGKYQNPDDQ  240

Query  718   TDTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEK  897
             TDTPDQYILPGTST L N S  EDCG AT++HA+ +SCNTV+GK+GA+LG +KL+AQAEK
Sbjct  241   TDTPDQYILPGTSTQLHNDSDDEDCGQATLKHALTISCNTVYGKLGADLGKEKLQAQAEK  300

Query  898   FGFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  1077
             FGFN  V IPIR+  S +P+ S PDGTAMDAIGQH+T ATPLQMAMVAAAIA+NG LM+P
Sbjct  301   FGFNSTVDIPIRSAKSVYPTDSTPDGTAMDAIGQHNTAATPLQMAMVAAAIADNGKLMQP  360

Query  1078  YLVAQEGSA-GNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGK  1254
             YLV +E SA G  +S H E QL QAVSPATAQKLQQ+M  VVQ+GTG NA+I GV VGGK
Sbjct  361   YLVDEERSAGGTTLSKHAEKQLGQAVSPATAQKLQQMMVDVVQNGTGRNARIDGVEVGGK  420

Query  1255  TGTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMM  1434
             TGTAQHG DN GLPFAWFVSYAK      VAVAVVVEDGS++  +ISGG LAAP+AK +M
Sbjct  421   TGTAQHGTDNKGLPFAWFVSYAKVGADTPVAVAVVVEDGSAQRGEISGGGLAAPVAKLIM  480

Query  1435  QAALGK  1452
             QAA+G+
Sbjct  481   QAAIGR  486


&gt;WP_084747517.1 penicillin-binding protein [Kitasatospora albolonga]
 ARF73734.1 penicillin-binding protein [Kitasatospora albolonga]
Length=485

 Score = 548 bits (1411),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 272/483 (56%), Positives = 349/483 (72%), Gaps = 3/483 (1%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKP+RRV+IFC +L+L+L+LR NW+Q  +A    N   N R + ++YA+ RGNIIV G+
Sbjct  1     MNKPLRRVAIFCGILMLSLLLRDNWIQYARADELTNRSENRRIRIERYAHERGNIIVDGK  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
             AVT S   NG  ++YKR W DGP++APVTGYSSQ +D+SQLE +EDGIL+G D +LFF  
Sbjct  61    AVTGSVETNGSDFRYKRVWKDGPLWAPVTGYSSQAFDSSQLENIEDGILTGNDDQLFFNR  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             TL M TG+ KQGG++VTT++   QKA F+GLG KKGA VA+DP+TGAIL L STPSYDP 
Sbjct  121   TLSMFTGQKKQGGNIVTTLNGAAQKAAFKGLGQKKGAVVALDPQTGAILALASTPSYDPS  180

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
              FAG +  D +A   L  D +KPMLNRALRETYPPGSTFK+VTAA A E G Y      T
Sbjct  181   VFAGNSTKDSEARQKLLDDKDKPMLNRALRETYPPGSTFKVVTAAAALENGLYDDIDAKT  240

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
             ++P  + LP T   L N      C +A+++ A+ +SCNTVFGK+  +LG  K+  Q +KF
Sbjct  241   ESPLPWTLPQTKVALQNQGNLP-CEDASLREALRVSCNTVFGKVSDDLGNKKMIEQTDKF  299

Query  901   GFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPY  1080
             GFNKEV  P+RADAS +P  ++P   AM  IGQ   R TPLQMAMV AAIAN+G LM+PY
Sbjct  300   GFNKEVFTPVRADASIYPEDNRPQ-NAMAGIGQASNRTTPLQMAMVTAAIANDGKLMKPY  358

Query  1081  LVAQEGSAG-NVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKT  1257
             +VA+  +   + + TH   +L +++S   AQKLQQ+ME+VV  GTGT A++PGVTVGGKT
Sbjct  359   MVAKRQTPDLDDVYTHQPEELGRSLSGENAQKLQQMMETVVNDGTGTRAQLPGVTVGGKT  418

Query  1258  GTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQ  1437
             GTAQHG +NS  P+AWF+SYAK  +G  VAVAVVVEDG++    ISGG LAAPIA+ +M+
Sbjct  419   GTAQHGLNNSEKPYAWFISYAKTDNGSPVAVAVVVEDGNANRGDISGGGLAAPIARDVMK  478

Query  1438  AAL  1446
             A +
Sbjct  479   AVI  481


&gt;WP_003978842.1 MULTISPECIES: penicillin-binding protein [Streptomycetaceae]
 KOG83606.1 penicillin-binding protein [Kitasatospora aureofaciens]
Length=489

 Score = 541 bits (1394),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 269/486 (55%), Positives = 355/486 (73%), Gaps = 5/486 (1%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKP+RRV+IFC +L+L+L++RVNWVQ VQA    N+ +N R   ++Y+ PRGNIIVGGQ
Sbjct  1     MNKPLRRVAIFCGLLVLSLLIRVNWVQFVQADELKNDTNNRRVAIERYSQPRGNIIVGGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
             A+T S   +   +KYKR++ DGPM+APVTGY+SQ + ++QLEKL D ILSGTD +LFF  
Sbjct  61    AITGSTTNDSGDFKYKRTYKDGPMWAPVTGYASQAFGSNQLEKLNDSILSGTDDKLFFSR  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
             T+DM TG+ ++GGDVVTT++PK QKA ++GLG  KGA  AI+P+TGAIL L STPSYDP 
Sbjct  121   TVDMFTGEKQKGGDVVTTLNPKAQKAAYDGLGKSKGAVAAINPETGAILALASTPSYDPS  180

Query  541   TFAGGTKDDEKAWTAL--DSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSD  714
             TFAG +  D KA+ AL   ++P+ PMLNRALR+TYPPGSTFK+VTAA A E G Y   + 
Sbjct  181   TFAGMSDKDAKAYNALLKKNNPDDPMLNRALRQTYPPGSTFKVVTAAAALENGLYTDINA  240

Query  715   VTDTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAE  894
              TD+P  + LP T+   +N      C NA+++ A+  SCNTVFGK+ A+LG  K++A+AE
Sbjct  241   KTDSPLPWYLPDTAHQPLNNEGNIPCENASLKEALRWSCNTVFGKISADLGNKKMKAEAE  300

Query  895   KFGFNK-EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLM  1071
             KFG+N  ++  P+RA  S +P+ ++P   AM  IGQ   RATPLQMAM+ +AIAN G LM
Sbjct  301   KFGYNDAKIDTPVRAAESVYPTDNRPQ-NAMAGIGQASNRATPLQMAMITSAIANGGKLM  359

Query  1072  EPYLVAQEGSAG-NVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVG  1248
             +PY+V +  +   NV+  HT   +SQ + P  AQKLQ++ME VV++GTGTN +I GVTVG
Sbjct  360   KPYMVDKLVAPNLNVVQQHTPEAMSQPLKPENAQKLQEMMEGVVKNGTGTNGQIDGVTVG  419

Query  1249  GKTGTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKA  1428
             GKTGTAQHG++N   P+AWF+SYAK   G  VAVAVV+E   +    I+GG LAAPIAK 
Sbjct  420   GKTGTAQHGENNKDNPYAWFISYAKTSKGTPVAVAVVIEGSDTLRGDIAGGKLAAPIAKK  479

Query  1429  MMQAAL  1446
             +M+A L
Sbjct  480   VMEAVL  485


&gt;WP_052836711.1 penicillin-binding protein 2 [Kitasatospora aureofaciens]
Length=490

 Score = 516 bits (1329),  Expect = 1e-180, Method: Compositional matrix adjust.
 Identities = 263/488 (54%), Positives = 345/488 (71%), Gaps = 8/488 (2%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKP+RR++IFC +L+L L++R NW+Q VQA     + HN R   ++YA PRG+IIV G+
Sbjct  1     MNKPLRRIAIFCGLLVLTLLIRDNWLQYVQADELKEDEHNRRVAIERYASPRGDIIVDGK  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
             A+T      G  +KYKR++ DG M+APVTGY SQ + A+QLE ++DGIL+G D RLFFRN
Sbjct  61    AITGHATTEG-DFKYKRTYKDGAMWAPVTGYVSQAFGATQLESIDDGILTGNDDRLFFRN  119

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNK--KGAAVAIDPKTGAILGLVSTPSYD  534
             TLDM+TG+ ++GG+VVTT++   QKA + GL  +  KGA VAI+P TG IL + S PSYD
Sbjct  120   TLDMITGEKREGGNVVTTLNSAAQKAAYNGLKKQGAKGAVVAIEPSTGKILSMASYPSYD  179

Query  535   PGTFAGGTKDDEKAWTALD--SDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSP  708
             P + AG      +AW  L   ++P+ PMLNRALRE YPPGSTFK+VTAA A E GKY S 
Sbjct  180   PTSIAGSNDAAGEAWNRLQKKNNPDDPMLNRALREAYPPGSTFKVVTAAAALEHGKYTSA  239

Query  709   SDVTDTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQ  888
              + TD+P  + +PGT+TPL N      C NAT++ A+ +SCNTVFGK+G +LG DK+   
Sbjct  240   DEKTDSPLPWTMPGTTTPLPNEGDLP-CENATLREALRVSCNTVFGKIGYDLGNDKMLET  298

Query  889   AEKFGFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSL  1068
             A+KFGF KE  +P+R+ AS F         A+ +IGQ +T ATPLQMAMV +AIANNG+L
Sbjct  299   AKKFGFTKEQFVPVRSSASVFSDDMNDSQVALSSIGQFNTAATPLQMAMVTSAIANNGTL  358

Query  1069  MEPYLV-AQEGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTV  1245
             M+PY+V A +    + I      ++S+ +S   AQ LQ +ME+VV+ GTGTNA+I GVTV
Sbjct  359   MKPYMVDALQAPNLDTIEKTDPEEMSKPLSADNAQILQSMMETVVKDGTGTNAQIDGVTV  418

Query  1246  GGKTGTAQHGQDNSGLPFAWFVSYAKGQDGKQ-VAVAVVVEDGSSEAQQISGGSLAAPIA  1422
             GGKTGTAQHG DNS  P+AWF+SYAK  DG   VAVAVV+ED ++    ISGG LAAPIA
Sbjct  419   GGKTGTAQHGVDNSENPYAWFISYAKTDDGSSPVAVAVVIEDENASRDDISGGGLAAPIA  478

Query  1423  KAMMQAAL  1446
             K +M+A +
Sbjct  479   KNVMEAVI  486


&gt;WP_003985178.1 MULTISPECIES: penicillin-binding protein [Streptomycetaceae]
 KOG71939.1 penicillin-binding protein [Kitasatospora aureofaciens]
Length=482

 Score = 514 bits (1323),  Expect = 1e-179, Method: Compositional matrix adjust.
 Identities = 273/484 (56%), Positives = 344/484 (71%), Gaps = 5/484 (1%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKP+RRVS+FC++LILAL+  V W+QG +A+T++++PHN R    KYA P GNI+VGGQ
Sbjct  1     MNKPLRRVSVFCILLILALLAWVTWLQGAKAATFSDDPHNPRVSIAKYANPLGNILVGGQ  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
              VT S   +G   KY+R++ +GP+YAPVTG+SSQ + ++QLE L   +L G+DSRL  +N
Sbjct  61    PVTGSTATDGT-LKYQRTYKNGPLYAPVTGFSSQIFGSNQLESLYGDLLDGSDSRL--QN  117

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
               D LT +  +GGDV TTID KVQ+AG++ LG K GAAVA+DP TG ILG+VSTPSYDPG
Sbjct  118   PGDALTRQRPKGGDVATTIDAKVQQAGYKALGGKSGAAVALDPATGKILGMVSTPSYDPG  177

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
              FAG    D+KAW  L  +   P +NRALR+  PPGSTFKLV AA A E G Y S  + T
Sbjct  178   KFAGSGSGDQKAWKDLSGNKAHPEINRALRQPLPPGSTFKLVVAAAALENGLYSSVDEAT  237

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
             D+PD Y LP T T L N S +  C NAT++ A+  SCNTVF KM A+LG DK+RAQAEKF
Sbjct  238   DSPDPYTLPNTRTVLKNESASAPCKNATIRTALQYSCNTVFAKMAADLGQDKVRAQAEKF  297

Query  901   GFNK-EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  1077
             GFN  ++  P+RA  S +P G     TA+  IGQ D  ATPLQMAMV++AIAN G L  P
Sbjct  298   GFNNGKLDTPVRAGKSLYPQGMDKPQTALSGIGQFDDTATPLQMAMVSSAIANGGDLQTP  357

Query  1078  YLVAQ-EGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGK  1254
              +V +     GN +  +   +  +AVS  TA++LQ  ME+VV  GTG+NAKI G+TVGGK
Sbjct  358   QMVDKLTDGGGNTLQEYEPKKYGKAVSRRTAEQLQSSMETVVNEGTGSNAKIDGLTVGGK  417

Query  1255  TGTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMM  1434
             TGTAQHG +N G P+AWFVSYAK   G QVAVAV+VED  +   +ISGG LAAP+AKAMM
Sbjct  418   TGTAQHGVNNEGTPYAWFVSYAKDGKGHQVAVAVMVEDSDAARSEISGGGLAAPVAKAMM  477

Query  1435  QAAL  1446
             +AAL
Sbjct  478   KAAL  481


&gt;WP_052841852.1 penicillin-binding protein 2 [Kitasatospora aureofaciens]
Length=484

 Score = 491 bits (1265),  Expect = 7e-171, Method: Compositional matrix adjust.
 Identities = 256/485 (53%), Positives = 327/485 (67%), Gaps = 6/485 (1%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NK IRR S+F L+L+ AL++R  WVQ  +    A++  N R   + YA P GNIIV G+
Sbjct  1     MNKTIRRASVFTLLLVFALLIRATWVQFYEGRALADSKDNRRGAIETYAEPLGNIIVAGR  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
             +VT S    G    YKR++ +G +YA VTGY+SQ Y  +QLE +   +L+GTD RL  R 
Sbjct  61    SVTGSAPTEGGDLAYKRTYENGKLYAAVTGYASQAYAPTQLEGIYQDVLNGTDPRL--RT  118

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
              +D +TG   + G+VVTTIDP VQKAGFE LG+ KGAAVAIDPKTG IL +VSTPSYDP 
Sbjct  119   VMDTVTGTRAEPGNVVTTIDPAVQKAGFEALGDTKGAAVAIDPKTGRILSVVSTPSYDPT  178

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
             +        E AW  L  DP+KP+ NRALR+  PPGSTFKLV AA A E G Y S  + T
Sbjct  179   SLTDANTAGE-AWKKLTGDPDKPLTNRALRQPLPPGSTFKLVVAAAALEDGLYGSVDERT  237

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
             D+PD Y LPGT+  L N +P   C NAT++ A+  SCN VF KM  +LG D+LRA AEKF
Sbjct  238   DSPDPYTLPGTTRDLSNENPDAPCENATIRTALQYSCNNVFAKMAVDLGQDELRAMAEKF  297

Query  901   GFNKEVT-IPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  1077
             GFN E   +P+RA  S +P       TA+  IGQ D  ATPLQMAMV+AA+AN G L+ P
Sbjct  298   GFNDETQDVPVRAYTSVYPKDMNRSSTALTGIGQFDVTATPLQMAMVSAALANGGELVSP  357

Query  1078  YLVAQ-EGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGK  1254
             ++V+Q   S G+ +  HT+    + VS ATA++L+  M +VV+ GTG+NA+I G TVGGK
Sbjct  358   HMVSQVTDSGGDALEDHTDAGSKRIVSSATAEQLRSAMRTVVEKGTGSNAQIAGATVGGK  417

Query  1255  TGTAQHGQDNSGLPFAWFVSYAKGQDG-KQVAVAVVVEDGSSEAQQISGGSLAAPIAKAM  1431
             TGTAQHG++NS  P+AWF SYAK     K+VAVAV+VE   +   ++SG  LAAP+AKAM
Sbjct  418   TGTAQHGENNSKTPYAWFTSYAKSDSSDKEVAVAVIVEQSDAARSEVSGNGLAAPVAKAM  477

Query  1432  MQAAL  1446
             M+AAL
Sbjct  478   MEAAL  482


&gt;WP_084745269.1 penicillin-binding protein [Kitasatospora albolonga]
 ARF71899.1 penicillin-binding protein [Kitasatospora albolonga]
Length=483

 Score = 481 bits (1238),  Expect = 7e-167, Method: Compositional matrix adjust.
 Identities = 251/487 (52%), Positives = 325/487 (67%), Gaps = 7/487 (1%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NK IRR S FCL+++LAL++R  WVQG +A   A+N HN R    +YA+P G+IIV G 
Sbjct  1     MNKTIRRASAFCLLMVLALLVRATWVQGYEAKALADNEHNRRNTIAQYAHPLGDIIVAGS  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
              VT S   +G   +YKR++  G +YA VTGYSSQ Y A+QLE +  G+L GTD RL  +N
Sbjct  61    PVTGSKGTSGGDLRYKRTYTQGELYAAVTGYSSQAYGATQLEGIYSGVLDGTDDRL--KN  118

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
               D++TG+    G+V+TTIDP VQKA +E LG  KGAAVAIDPKTG ILG+VSTPSYDP 
Sbjct  119   PADLITGRQAVPGNVLTTIDPGVQKAAYEALGGDKGAAVAIDPKTGRILGMVSTPSYDPS  178

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
               +G    D  AW  L  D +KP++NRALR+   PGSTFKLV AA A E G Y S  + T
Sbjct  179   EISG--TGDGDAWRKLLDDKDKPLVNRALRQPLAPGSTFKLVVAAAALENGLYGSVDEAT  236

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
             D+PD Y LPGT T L N + +  C NAT++ A+  SCN VF K  A+LG DK++  A+ F
Sbjct  237   DSPDPYTLPGTRTILRNENASAPCENATLRTALQYSCNNVFAKAAADLGQDKVKEMADAF  296

Query  901   GFNKE-VTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  1077
             GF+ E + +P+RA  S +P+G     TA+  IGQ +  ATPLQMAMV AA+AN G L  P
Sbjct  297   GFDTEKLDVPVRASKSVYPTGMDKAQTALTGIGQFEVTATPLQMAMVTAALANGGELAAP  356

Query  1078  YLVAQEGSA-GNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGK  1254
             ++V+      G+ +    +    + V   TA++L+  M +VV+ GTGTNA+I G  VGGK
Sbjct  357   HMVSSVTDGDGSALEKTEDGDTKRVVDEKTAEQLRSAMVTVVEEGTGTNARIAGAEVGGK  416

Query  1255  TGTAQHGQDNSGLPFAWFVSYAK-GQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAM  1431
             TGTAQ+G DNS  P+AWF SYAK    GK+VAVAV+VED  S   ++SG  LAAPIA+ M
Sbjct  417   TGTAQNGVDNSNTPYAWFTSYAKDDSSGKEVAVAVIVEDSGSARSEVSGNGLAAPIAQKM  476

Query  1432  MQAALGK  1452
             M+AAL +
Sbjct  477   MKAALER  483


&gt;WP_051969980.1 penicillin-binding protein [Kitasatospora azatica]
Length=497

 Score = 461 bits (1185),  Expect = 1e-158, Method: Compositional matrix adjust.
 Identities = 253/483 (52%), Positives = 321/483 (66%), Gaps = 8/483 (2%)
 Frame = +1

Query  16    RRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKS  195
             RR   FCLVL +AL  +   VQ   A T+ +NP N RT   +YA PRGN++VG   VT S
Sbjct  15    RRAGTFCLVLTVALAAQATRVQFFNAETYNDNPANQRTTIQRYAQPRGNLLVGADPVTGS  74

Query  196   DFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDML  375
                 G RY YKR++ +GP YA VTG+SSQ +  +QLE  ED +L+GTD+RL      D +
Sbjct  75    TATGG-RYDYKRTYTEGPQYAAVTGFSSQIFGNTQLEGTEDALLTGTDNRLAGWALWDAI  133

Query  376   TGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGG  555
             + K   GGDV TTI    Q+A  +GLGN+KGA  AI+P TG IL L STPSYDPG+FAG 
Sbjct  134   SRKQSPGGDVYTTISKAAQQAAVQGLGNQKGAVAAIEPGTGRILALASTPSYDPGSFAGS  193

Query  556   TKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQ  735
                D++AW  L +D N+PMLNRALR+TYPPGSTFK+VTAA A   G     +  T  P  
Sbjct  194   AAADQEAWNKLQADSNQPMLNRALRQTYPPGSTFKVVTAAAALANGVVTDINAPTGAPYP  253

Query  736   YILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-  912
             Y+LPGT+T L+N + + D  N  +  AM LSCN+V G +G + G DK+ + A+KFGFN  
Sbjct  254   YVLPGTTTELVNDTSSCDQPNLDLDTAMTLSCNSVLGYLGVQTGLDKMVSMAQKFGFNDA  313

Query  913   EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ  1092
              + IP+RA  S+F +       A+ +IGQ DT ATPL MAMVAA +ANNG++M P LV +
Sbjct  314   RLDIPVRAARSNFDTSMNQSQVALSSIGQFDTAATPLVMAMVAAGVANNGTVMYPQLVDK  373

Query  1093  -EGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ  1269
                S G+ I     H   QA+SPA A ++QQLM  VVQ+GTG NA+I G TVGGKTGTAQ
Sbjct  374   LTKSDGSTIQLMKPHPYQQAMSPAVAGQVQQLMTDVVQNGTGRNARIAGATVGGKTGTAQ  433

Query  1270  HGQDNSGLPFAWFVSYAK---GQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQA  1440
             HG DNSG+P+AWF+S+A+     D   VAVAVV+ D  SEA  ++GG LAAPIAK++MQA
Sbjct  434   HGVDNSGVPYAWFISWARPTGSTDVPPVAVAVVIAD--SEATDVTGGGLAAPIAKSVMQA  491

Query  1441  ALG  1449
              LG
Sbjct  492   VLG  494


&gt;WP_030393477.1 MULTISPECIES: penicillin-binding protein [Kitasatospora]
Length=486

 Score = 447 bits (1151),  Expect = 1e-153, Method: Compositional matrix adjust.
 Identities = 240/482 (50%), Positives = 315/482 (65%), Gaps = 4/482 (1%)
 Frame = +1

Query  16    RRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKS  195
             RR   FCL+L +AL ++   VQ  +A    +N  N R   ++Y+ PRG+I VG  +VT S
Sbjct  6     RRAGTFCLLLTVALCVQATRVQVFRADELNHNSANQRLVVERYSQPRGSIRVGADSVTGS  65

Query  196   DFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDML  375
             +   G RY YKR++ DGP+YA VTGYSSQTY  SQLE  ED +LSGTDSRL      D +
Sbjct  66    EPTGG-RYDYKRTYTDGPLYAAVTGYSSQTYGNSQLEGTEDALLSGTDSRLASWAVWDAV  124

Query  376   TGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGG  555
               +   GGDV TT+D  VQ+A   GLG +KGA  A++P TG IL L STPSYDPG+FAG 
Sbjct  125   ARRQNPGGDVRTTVDRAVQEAAVRGLGRQKGAVAAVEPATGRILALASTPSYDPGSFAGT  184

Query  556   TKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQ  735
             + DD +AW+ L SDP++PMLNRALR+TYPPGSTFK+VTAA A E+G        TDTP+ 
Sbjct  185   SADDREAWSRLQSDPDRPMLNRALRQTYPPGSTFKVVTAAAALESGVVTDVDAPTDTPNP  244

Query  736   YILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-  912
             Y+LPGTS PL+N S   D  N ++  AM LSCN+V G++G E+G  ++ A AE FGFN+ 
Sbjct  245   YLLPGTSVPLVNDSAACDEPNQSLATAMALSCNSVLGRLGVEVGLRRMAATAEGFGFNEA  304

Query  913   EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ  1092
              +  P+RA  S+F +       A+ +IGQ DT ATPL MAMVAA IANNG++M P LV  
Sbjct  305   RLDTPVRAARSNFDTRMDEAQLALSSIGQFDTAATPLVMAMVAAGIANNGTVMRPQLVDS  364

Query  1093  EGSA-GNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ  1269
               +A G V+ +       QAV P TA ++++LM   V++GTG  A+I G  VGGKTGTAQ
Sbjct  365   LTAADGTVVHSVRPSVYRQAVGPGTAGQVRRLMVDAVENGTGRAARIDGAVVGGKTGTAQ  424

Query  1270  HGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQ-QISGGSLAAPIAKAMMQAAL  1446
             HG DN+G P+AWF+++A       V    V    +     +++GG LAAP+A+A+MQA L
Sbjct  425   HGVDNTGTPYAWFIAWAAPAGSAAVPPVAVAVVVADSDATEVTGGGLAAPVARAVMQAVL  484

Query  1447  GK  1452
              +
Sbjct  485   SR  486


&gt;WP_051966736.1 penicillin-binding protein [Kitasatospora mediocidica]
Length=499

 Score = 446 bits (1146),  Expect = 1e-152, Method: Compositional matrix adjust.
 Identities = 250/480 (52%), Positives = 312/480 (65%), Gaps = 4/480 (1%)
 Frame = +1

Query  16    RRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKS  195
             RR  +FCLVLILAL  +  WVQ  QA  + +N  N RT  ++YA PRGNI+VG   VT S
Sbjct  18    RRAGMFCLVLILALAGQATWVQVFQAKAYDDNAANQRTAIERYAQPRGNILVGAAPVTGS  77

Query  196   DFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDML  375
                 G R+ YKR++ DG  +A VTG+SSQ Y  +QLE  ED +LSGTD+RL      D +
Sbjct  78    APTGG-RFDYKRTYTDGSQFAAVTGFSSQIYGNTQLEGTEDSLLSGTDNRLAGWALWDEI  136

Query  376   TGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGG  555
             + K   GGDV TTI    Q+A  +GLGN+KGA  AI+P TG IL L STPSYDPG+FAG 
Sbjct  137   SRKQNPGGDVYTTISKAAQQAAMQGLGNQKGAVAAIEPSTGRILALASTPSYDPGSFAGS  196

Query  556   TKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQ  735
             T  D+ AW AL +D N+PMLNRALR+TYPPGSTFK+VTAA A   G     +  T  P  
Sbjct  197   TAADQNAWNALQADTNQPMLNRALRQTYPPGSTFKVVTAAAALANGTVTDINAPTGAPSP  256

Query  736   YILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-  912
             Y+LPGT+T L+N +   D    ++  AM LSCN+V G +G + G DK+ A AE FGFN  
Sbjct  257   YVLPGTTTTLVNDTTACDRSGLSLDTAMVLSCNSVLGYLGVQTGLDKMTAMAENFGFNDA  316

Query  913   EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ  1092
             ++ IP+RA  S+F +       A+ +IGQ DT ATPL MAMVAA +ANNG++M P LV +
Sbjct  317   KLDIPVRAARSNFDTRMNQSQVALSSIGQFDTAATPLVMAMVAAGVANNGTVMYPQLVDK  376

Query  1093  -EGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ  1269
                S G  +         QA+SPA A ++QQLM  VV +GTG NA+I G TVGGKTGTAQ
Sbjct  377   LTKSDGTTVQVMKPSTYKQAMSPAVAGQVQQLMTDVVDNGTGRNARISGATVGGKTGTAQ  436

Query  1270  HGQDNSGLPFAWFVSYAK-GQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAAL  1446
             HG DNSG P+AWF+S+AK         VAV V    S A  ++GG LAAPIAK++MQA L
Sbjct  437   HGVDNSGTPYAWFISWAKPAGSSAVPPVAVAVVIADSNATDVTGGGLAAPIAKSVMQAVL  496


&gt;AUG79326.1 Putative penicillin-binding protein A [Kitasatospora sp. MMS16-BH015]
Length=516

 Score = 445 bits (1144),  Expect = 4e-152, Method: Compositional matrix adjust.
 Identities = 240/482 (50%), Positives = 312/482 (65%), Gaps = 4/482 (1%)
 Frame = +1

Query  16    RRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKS  195
             RR   FC++LI+AL ++   +Q  QA +  +N  N R   ++Y  PRGNI+VG   VT S
Sbjct  36    RRAGTFCMLLIVALAVQATRIQVFQADSLDHNSANQRLTIERYGQPRGNILVGADPVTGS  95

Query  196   DFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDML  375
                 G RY YKR++ DGP YA VTG+SSQTY  +QLE  ED +LSGTD+RL      D +
Sbjct  96    APTGG-RYDYKRTYTDGPQYAAVTGFSSQTYGNTQLEGTEDELLSGTDTRLAGWALWDEI  154

Query  376   TGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGG  555
               K   GGDV TTID   Q+A  +GLG++KGA  AI+P TG IL L STPSYDPG+FAG 
Sbjct  155   ARKQNPGGDVFTTIDKAAQQAAMKGLGDQKGAVAAIEPATGRILALASTPSYDPGSFAGA  214

Query  556   TKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQ  735
              K D++AW  L +D N+PMLNRALR+ YPPGSTFK+VTA  A   G        T  P  
Sbjct  215   GKTDQQAWDRLQADTNQPMLNRALRQIYPPGSTFKVVTATAALANGVVTDIDKGTGAPYP  274

Query  736   YILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-  912
             Y++PGT+TPL+N +   D  N T+  AM  SCN+V G +G ++G DK+ A A+ FGFN  
Sbjct  275   YVMPGTTTPLVNDTTACDEPNQTLDQAMVSSCNSVMGYLGVQVGLDKMVAMAQSFGFNDP  334

Query  913   EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ  1092
              + IP+RA  S+F +       A+ +IGQ DT ATPL MAMVAA +ANNG++M P LV +
Sbjct  335   RLDIPVRAARSNFDTKMNQSQVALSSIGQFDTAATPLVMAMVAAGVANNGTVMHPQLVDK  394

Query  1093  -EGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ  1269
                S G+ +         QA+SPA A+++QQLM  VV+ GTG +A+I G TVGGKTGTAQ
Sbjct  395   LTKSDGSSVQVMKPRTYRQAMSPAVARQVQQLMTDVVESGTGCSARIGGATVGGKTGTAQ  454

Query  1270  HGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVED-GSSEAQQISGGSLAAPIAKAMMQAAL  1446
             HG DNSG+P+AWF+S+AK     QV    V      S A  ++GG LAAPIA+++MQ+ L
Sbjct  455   HGVDNSGIPYAWFISWAKPSGSDQVPPVAVAVVIADSGATDVTGGGLAAPIARSVMQSIL  514

Query  1447  GK  1452
              +
Sbjct  515   DR  516


&gt;AUG79205.1 penicillin-binding protein [Kitasatospora sp. MMS16-BH015]
Length=492

 Score = 441 bits (1135),  Expect = 3e-151, Method: Compositional matrix adjust.
 Identities = 245/486 (50%), Positives = 318/486 (65%), Gaps = 5/486 (1%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             + + IRR S+FCL+L+LALM+RV W+   +A ++  NP N R   D+YA P GNI+VGGQ
Sbjct  10    MTRSIRRASLFCLLLVLALMVRVTWIAVAKADSYDKNPANARNTIDRYADPLGNILVGGQ  69

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
              VT S    G    Y+R++ DGP+YAPVTGYSSQ Y ++QLE L   +L G+D RL   +
Sbjct  70    PVTGSK-AGGGSLAYQRTYADGPLYAPVTGYSSQAYGSTQLENLYGPLLDGSDPRL--AS  126

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
                 LT     GGDVVT+IDP VQ+A +  LG K+GAAVAIDP TG IL LVSTPS+DP 
Sbjct  127   PFAALTRDRPAGGDVVTSIDPAVQQAAWNALGGKQGAAVAIDPDTGRILALVSTPSWDPN  186

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
                G +  D  AW  L +D    MLN ALR TY PGSTFKLVT A A E G Y      T
Sbjct  187   RITGRSAADAAAWKQLSADNGSAMLNSALRSTYAPGSTFKLVTLAAALENGLYSDVDQPT  246

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
             D+PD Y LPGT T L N +P+  C NA+++ A++ SCN VF K+ A+LG  K+ AQA KF
Sbjct  247   DSPDPYTLPGTRTVLTNENPSAPCTNASLRTALEYSCNNVFAKVAADLGETKMAAQAAKF  306

Query  901   GFN-KEVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  1077
             GF   ++ +P+RA  S +PSG +    A+  IGQ    ATPLQMAMV+AA+AN G LM+P
Sbjct  307   GFGLGQLDVPVRAAESVYPSGMEKSQVALTGIGQFSVTATPLQMAMVSAAVANGGVLMKP  366

Query  1078  YLVAQ-EGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGK  1254
              +V +    +G  +      +L Q +S  TA ++   M SVV  GTG  A + G+TVGGK
Sbjct  367   SMVEKLTDHSGRTVQEFGPARLDQVMSKRTADQIHSAMVSVVTAGTGRAAAVKGLTVGGK  426

Query  1255  TGTAQHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMM  1434
             TGTAQ+G DNSG+P+AWF S+A+   GK++A AVVV DGS++   ++GG LA P++KAM 
Sbjct  427   TGTAQNGIDNSGIPYAWFTSFAEDGSGKRIATAVVVLDGSADRDAVTGGGLAGPVSKAMA  486

Query  1435  QAALGK  1452
             QA L +
Sbjct  487   QAYLKR  492


&gt;WP_084746985.1 penicillin-binding protein 2 [Kitasatospora albolonga]
 ARF73187.1 penicillin-binding protein [Kitasatospora albolonga]
Length=494

 Score = 440 bits (1132),  Expect = 1e-150, Method: Compositional matrix adjust.
 Identities = 235/494 (48%), Positives = 325/494 (66%), Gaps = 10/494 (2%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +N+P+R ++IFC +L+LAL+LR NW+Q V     + +  N R +++++A PRG+IIVGG+
Sbjct  1     MNRPLRHIAIFCGLLMLALLLRANWLQQVDRVELSQHERNVRVRFERFASPRGDIIVGGK  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
             A+T S   +   Y ++R+W DGPMYAPVTGY+SQ    S LE+  D +LSG D R  FR+
Sbjct  61    AITGSKETDSRDYTFRRTWKDGPMYAPVTGYASQAQGTSLLERTYDSVLSGQDDRFAFRH  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGN--KKGAAVAIDPKTGAILGLVSTPSYD  534
               D+LTG+P++GG VVTTID K QKAG++GL +   +G+ VA+DP+TG +L LVSTPSYD
Sbjct  121   AKDVLTGQPRRGGSVVTTIDAKAQKAGYKGLTDLGARGSVVALDPRTGRVLALVSTPSYD  180

Query  535   PGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSD  714
             P  FAG +  +   + AL  D NKP+ NRALRET+PPGSTFK++TAA A E G       
Sbjct  181   PEVFAGISFKESDRFKALLEDKNKPLANRALRETFPPGSTFKILTAAAALEHGVITDVDA  240

Query  715   VTDTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAE  894
              T     Y LP ++  + + +    CG A+++ AM  SCN VF  + AE+G DK+R  AE
Sbjct  241   PTKAVSPYPLPLSTNKVGSEAGDAVCGKASLKTAMQYSCNNVFLDVAAEMGEDKMRETAE  300

Query  895   KFGFNKEVTIP----IRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNG  1062
             KFGFNK+V       + A  S +P      GTA+  +GQ    +TP+QMAMV AA+AN+G
Sbjct  301   KFGFNKDVYAEEFGDMLATKSLYPEKLDKPGTALTGMGQGSLTSTPMQMAMVTAALANDG  360

Query  1063  SLMEPYLVAQ-EGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGV  1239
              LM+P++V Q  G   + +  +   ++SQAVSP TA+K+Q++ME   + G+   A+I GV
Sbjct  361   KLMQPHIVDQLRGPDLSTLEKNEPAEMSQAVSPETAKKIQEMMEHTAKEGSAQRAQINGV  420

Query  1240  TVGGKTGTAQHGQD-NSGLPFAWFVSYAKGQDGKQVAVAVVVE--DGSSEAQQISGGSLA  1410
             TVGGKTGTAQ G +    +P+ WFVSY K  DG+ VAVAV ++  D       ISGG L 
Sbjct  421   TVGGKTGTAQRGVNVRDQVPYGWFVSYGKKDDGRSVAVAVFIDPTDMDISRSDISGGRLG  480

Query  1411  APIAKAMMQAALGK  1452
             APIAK +M+A LG+
Sbjct  481   APIAKKVMEAVLGE  494


&gt;WP_003981922.1 MULTISPECIES: penicillin-binding protein 2 [Streptomycetaceae]
 KOG83773.1 penicillin-binding protein [Kitasatospora aureofaciens]
Length=489

 Score = 439 bits (1130),  Expect = 2e-150, Method: Compositional matrix adjust.
 Identities = 233/490 (48%), Positives = 313/490 (64%), Gaps = 7/490 (1%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +N+P+R +++FC VL+LAL++R  WVQ VQA   AN+ +N R K + ++YPRGNIIVGG+
Sbjct  1     MNRPLRHIAVFCGVLVLALLVRATWVQFVQADALANDDNNRRVKIEAFSYPRGNIIVGGK  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
              +T S    G  +KYKR + DGPMYAP+TGY+SQ+   + LE +   ILSG D RLF + 
Sbjct  61    PITGSVETAG-DFKYKRVYKDGPMYAPITGYASQSQGTTFLEGVYKDILSGKDDRLFLKR  119

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLG--NKKGAAVAIDPKTGAILGLVSTPSYD  534
               D+LTG+  +GGDV+TTI+ K Q+  ++ L   N KGA VA++P TG IL + STPSYD
Sbjct  120   AKDVLTGEKPRGGDVLTTINEKAQRTAYKALTDLNAKGAVVALEPATGKILAMASTPSYD  179

Query  535   PGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSD  714
             P  FAG +  +   +T+L  D  KPM NRA  E YPPGSTFK++TAA A E G       
Sbjct  180   PSVFAGSSFKEGDKYTSLIKDKAKPMNNRASLEIYPPGSTFKILTAAAALEHGIVPDIDT  239

Query  715   VTDTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAE  894
                 P  Y LP T+T + N   T  C NA+++  M  SCN  + +    LG DK+R  AE
Sbjct  240   PVQAPVPYTLPQTATKVGNDIATAPCANASLKVGMQWSCNNTYLEAANRLGTDKMRETAE  299

Query  895   KFGFNKEVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLME  1074
             KFGFN+++  P+R   S +P       TA+  +GQ    +TPLQMAMV A +ANNG +M+
Sbjct  300   KFGFNQKIFTPVRTATSGYPKKLDKPQTALTGMGQGSLTSTPLQMAMVVAGLANNGKVMQ  359

Query  1075  PYLVAQ-EGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGG  1251
             PY+V +  G   + I      +LSQAVS +TA+K+Q++ME+  ++GT   A I GV VG 
Sbjct  360   PYMVEETRGPDLSTIEKFEPKELSQAVSESTAKKVQEMMENTAENGTAKKALIDGVKVGA  419

Query  1252  KTGTAQHGQD-NSGLPFAWFVSYAKGQDGKQVAVAVVVE--DGSSEAQQISGGSLAAPIA  1422
             KTGTAQHG D     P+AWFVSYAK  +G  VAVAV V+  D     ++I+GG L  PIA
Sbjct  420   KTGTAQHGADVRDERPYAWFVSYAKQGNGSPVAVAVFVDPSDMDIPRKEIAGGKLGGPIA  479

Query  1423  KAMMQAALGK  1452
             K +M+A LGK
Sbjct  480   KKVMEAVLGK  489


&gt;WP_052836864.1 penicillin-binding protein 2 [Kitasatospora aureofaciens]
Length=495

 Score = 436 bits (1122),  Expect = 4e-149, Method: Compositional matrix adjust.
 Identities = 234/493 (47%), Positives = 319/493 (65%), Gaps = 11/493 (2%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +NKP+R V+IFC +L+L L++R NW+Q V+A   A++  N R + +++A PRG+IIVGG+
Sbjct  1     MNKPLRAVAIFCGLLVLGLLIRANWLQYVRAPELASDTKNRRVQIEQFATPRGDIIVGGR  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
             AVT S        KYKR++VDGPMYAPVTGY+SQ    + LEK  D IL+G D RL F+ 
Sbjct  61    AVTGSKETETTDLKYKRTYVDGPMYAPVTGYASQAQGMTLLEKTYDSILTGKDDRLAFQR  120

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKK---GAAVAIDPKTGAILGLVSTPSY  531
               D+++G+ ++ G VVTTIDPK QKA ++GL + K   GA VA+DP+TG +L +VS PSY
Sbjct  121   FADVVSGEGRRAGSVVTTIDPKAQKAAWDGLTDLKGARGAVVALDPQTGKVLAMVSAPSY  180

Query  532   DPGTFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPS  711
             DP TFAG T  +   + ALD   NKP+ NRALRETYPPGSTFK++TAA A E G      
Sbjct  181   DPSTFAGSTFKESDRFVALDKKKNKPLANRALRETYPPGSTFKILTAAAALEHGIVTDVD  240

Query  712   DVTDTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQA  891
               TD    Y LP ++  + + +    C  A+++ AM  SCN VF    ++LG +K+R  A
Sbjct  241   ARTDAVSPYPLPQSTNKIGSEAGDAVCNKASMKTAMQHSCNNVFLDAASKLGQEKMRETA  300

Query  892   EKFGFNKEVTI----PIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANN  1059
             EKFGFN++V       + A  S +P      GTA+  +GQ    +TP+QMA+V A IAN+
Sbjct  301   EKFGFNEDVYSDDFGDLLATKSLYPEDLDKPGTALTGMGQGSLTSTPMQMALVTAGIAND  360

Query  1060  GSLMEPYLVAQ-EGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPG  1236
             G +M+PY+V + +G   + +       +S+AVS  TAQK+Q++ME   + G+   A+I G
Sbjct  361   GKVMQPYVVDEVKGPDLDTLEKTEPAVMSEAVSAETAQKVQEMMEFTAKEGSARRAQIDG  420

Query  1237  VTVGGKTGTAQHGQD-NSGLPFAWFVSYAKGQDGKQVAVAVVVE--DGSSEAQQISGGSL  1407
             VTVGGKTGTAQ G D N  +P+ WFVSY K  DG  VAVAV ++  D       ISGG L
Sbjct  421   VTVGGKTGTAQRGVDVNDEVPYGWFVSYGKKDDGSSVAVAVFIDPTDMDISRADISGGGL  480

Query  1408  AAPIAKAMMQAAL  1446
              APIAK++M+A L
Sbjct  481   GAPIAKSVMKAVL  493


&gt;WP_078656350.1 penicillin-binding protein [Kitasatospora aureofaciens]
Length=502

 Score = 435 bits (1119),  Expect = 1e-148, Method: Compositional matrix adjust.
 Identities = 240/483 (50%), Positives = 311/483 (64%), Gaps = 6/483 (1%)
 Frame = +1

Query  16    RRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKS  195
             RR + FCL+L+ AL ++   VQ  +++   +N  N R   ++YA PRG+I+VGG+ VT S
Sbjct  22    RRAATFCLLLVGALCVQATRVQVFESADLDHNTANQRLTIERYARPRGDILVGGRPVTGS  81

Query  196   DFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDML  375
                 G RY YKR + DGP YA VTG++SQ Y  SQLE  EDG+L+GTD RL   +  D +
Sbjct  82    RPTGG-RYAYKRGYTDGPTYAAVTGFASQAYGNSQLEGTEDGLLTGTDGRLTGWSLWDAI  140

Query  376   TGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGG  555
             T +   GGDV TTIDP  Q+A   GLG +KGA  AI+P TG IL L STPSYDPG FAG 
Sbjct  141   TRRQNPGGDVHTTIDPAAQQAAMSGLGGRKGAVAAIEPATGRILALASTPSYDPGDFAGS  200

Query  556   TKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQ  735
             +  D  AW  L  D ++PMLNRALR+TYPPGSTFK+VTAA A   G    P   TD P  
Sbjct  201   SGADRTAWNRLRDDTDQPMLNRALRQTYPPGSTFKVVTAAAALSAGVVTDPGAPTDAPFP  260

Query  736   YILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-  912
             Y+LPGT+TPL+N S   D    ++  AM  SCN+V G +G   G  K+ A AE FGFN  
Sbjct  261   YVLPGTTTPLVNDSADCDRPGLSLDAAMTASCNSVLGYLGVRTGLSKVVATAEGFGFNDP  320

Query  913   EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ  1092
              + +P+R   S+  +   P   A+ +IGQ DT ATPL MAMVAA IAN+G++M P LV +
Sbjct  321   RLDVPVRPVRSNVDTSMDPAELALSSIGQFDTAATPLVMAMVAAGIANDGTVMRPQLVDK  380

Query  1093  -EGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ  1269
                S G  +         +AV+PA A ++++LM  VV++GTG NA+I G  VGGKTGTAQ
Sbjct  381   LTRSDGTEVELMRPAVYRRAVTPAVAGQVRKLMTDVVENGTGGNARIAGAVVGGKTGTAQ  440

Query  1270  HGQDNSGLPFAWFVSYA--KGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAA  1443
             HG DNSG P+AWF+S+A   G D     VAV V    S+A  ++GG+LAAPIA+++M+A 
Sbjct  441   HGVDNSGTPYAWFISWAGPAGSD-AVPPVAVAVVVADSDATDVTGGALAAPIARSVMRAV  499

Query  1444  LGK  1452
             LG+
Sbjct  500   LGR  502


&gt;OEV33654.1 penicillin-binding protein [Kitasatospora aureofaciens]
Length=486

 Score = 432 bits (1112),  Expect = 1e-147, Method: Compositional matrix adjust.
 Identities = 239/483 (49%), Positives = 309/483 (64%), Gaps = 6/483 (1%)
 Frame = +1

Query  16    RRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKS  195
             RR + FCL+L+ AL ++    Q  +++   +N  N R   ++YA PRG+I+VGG+ VT S
Sbjct  6     RRAATFCLLLVGALCVQATRAQVFESADLDHNTANQRLTIERYARPRGDILVGGRPVTGS  65

Query  196   DFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDML  375
                 G RY YKR + DGP YA VTG++SQ Y  SQLE  EDG+L+GTD RL   +  D +
Sbjct  66    RPTGG-RYAYKRGYTDGPTYAAVTGFASQAYGNSQLEGTEDGLLTGTDGRLTGWSLWDAI  124

Query  376   TGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGG  555
             T +   GGDV TTIDP  Q+A   GLG +KGA  AI+P TG IL L STPSYDPG FAG 
Sbjct  125   TRRQNPGGDVHTTIDPAAQQAAMSGLGGRKGAVAAIEPATGRILALASTPSYDPGDFAGS  184

Query  556   TKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQ  735
             +  D  AW  L  D ++PMLNRALR+TYPPGSTFK+VTAA A   G    P   TD P  
Sbjct  185   SGADRTAWNRLRDDTDQPMLNRALRQTYPPGSTFKVVTAAAALSAGVVTDPGAPTDAPFP  244

Query  736   YILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-  912
             Y+LPGT+TPL+N S   D    ++  AM  SCN+V G +G   G  K+ A AE FGFN  
Sbjct  245   YVLPGTTTPLVNDSADCDRPGLSLDAAMTASCNSVLGYLGVRTGLSKVVATAEGFGFNDP  304

Query  913   EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ  1092
              + +P+R   S+  +   P   A+ +IGQ DT ATPL MAMVAA IAN+G++M P LV +
Sbjct  305   RLDVPVRPVRSNVDTSMDPAELALSSIGQFDTAATPLVMAMVAAGIANDGTVMRPQLVDK  364

Query  1093  -EGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ  1269
                S G  +         +AV+PA A ++++LM  VV+ GTG NA+I G  VGGKTGTAQ
Sbjct  365   LTRSDGTEVELMRPAVYRRAVTPAVAGQVRKLMTDVVEDGTGGNARIAGAVVGGKTGTAQ  424

Query  1270  HGQDNSGLPFAWFVSYA--KGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAA  1443
             HG DNSG P+AWF+S+A   G D     VAV V    S+A  ++GG+LAAPIA+++M+A 
Sbjct  425   HGVDNSGTPYAWFISWAGPAGSD-AVPPVAVAVVVADSDATDVTGGALAAPIARSVMRAV  483

Query  1444  LGK  1452
             LG+
Sbjct  484   LGR  486


&gt;WP_078938872.1 MULTISPECIES: penicillin-binding protein [Streptomycetaceae]
 ARF78986.1 penicillin-binding protein [Kitasatospora aureofaciens]
Length=502

 Score = 432 bits (1112),  Expect = 1e-147, Method: Compositional matrix adjust.
 Identities = 239/483 (49%), Positives = 309/483 (64%), Gaps = 6/483 (1%)
 Frame = +1

Query  16    RRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKS  195
             RR + FCL+L+ AL ++    Q  +++   +N  N R   ++YA PRG+I+VGG+ VT S
Sbjct  22    RRAATFCLLLVGALCVQATRAQVFESADLDHNTANQRLTIERYARPRGDILVGGRPVTGS  81

Query  196   DFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDML  375
                 G RY YKR + DGP YA VTG++SQ Y  SQLE  EDG+L+GTD RL   +  D +
Sbjct  82    RPTGG-RYAYKRGYTDGPTYAAVTGFASQAYGNSQLEGTEDGLLTGTDGRLTGWSLWDAI  140

Query  376   TGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGG  555
             T +   GGDV TTIDP  Q+A   GLG +KGA  AI+P TG IL L STPSYDPG FAG 
Sbjct  141   TRRQNPGGDVHTTIDPAAQQAAMSGLGGRKGAVAAIEPATGRILALASTPSYDPGDFAGS  200

Query  556   TKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQ  735
             +  D  AW  L  D ++PMLNRALR+TYPPGSTFK+VTAA A   G    P   TD P  
Sbjct  201   SGADRTAWNRLRDDTDQPMLNRALRQTYPPGSTFKVVTAAAALSAGVVTDPGAPTDAPFP  260

Query  736   YILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-  912
             Y+LPGT+TPL+N S   D    ++  AM  SCN+V G +G   G  K+ A AE FGFN  
Sbjct  261   YVLPGTTTPLVNDSADCDRPGLSLDAAMTASCNSVLGYLGVRTGLSKVVATAEGFGFNDP  320

Query  913   EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ  1092
              + +P+R   S+  +   P   A+ +IGQ DT ATPL MAMVAA IAN+G++M P LV +
Sbjct  321   RLDVPVRPVRSNVDTSMDPAELALSSIGQFDTAATPLVMAMVAAGIANDGTVMRPQLVDK  380

Query  1093  -EGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ  1269
                S G  +         +AV+PA A ++++LM  VV+ GTG NA+I G  VGGKTGTAQ
Sbjct  381   LTRSDGTEVELMRPAVYRRAVTPAVAGQVRKLMTDVVEDGTGGNARIAGAVVGGKTGTAQ  440

Query  1270  HGQDNSGLPFAWFVSYA--KGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAA  1443
             HG DNSG P+AWF+S+A   G D     VAV V    S+A  ++GG+LAAPIA+++M+A 
Sbjct  441   HGVDNSGTPYAWFISWAGPAGSD-AVPPVAVAVVVADSDATDVTGGALAAPIARSVMRAV  499

Query  1444  LGK  1452
             LG+
Sbjct  500   LGR  502


&gt;BAJ30397.1 putative penicillin-binding protein A [Kitasatospora setae KM-6054]
Length=504

 Score = 431 bits (1108),  Expect = 6e-147, Method: Compositional matrix adjust.
 Identities = 243/482 (50%), Positives = 311/482 (65%), Gaps = 4/482 (1%)
 Frame = +1

Query  16    RRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKS  195
             RR   FC++LI+AL L+   VQ  Q     +N  N R    +YA PRGN++VGGQ VT S
Sbjct  24    RRAGTFCMLLIVALALQATRVQVFQKKELDHNSANQRATIQRYAQPRGNLLVGGQPVTGS  83

Query  196   DFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDML  375
                 G RY Y+R++ DGP+YA VTGYSSQTY  +QLE ++D +LSGTD RL      D +
Sbjct  84    SATGG-RYAYQRTYTDGPLYAAVTGYSSQTYGNTQLEGVDDDLLSGTDPRLAGWAVWDAV  142

Query  376   TGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGG  555
             T + + GGDVVTTIDP  Q+A   GLGN+KGA  AI+P TG IL L STPSYDPG+FAG 
Sbjct  143   TRQQQPGGDVVTTIDPAAQRAALRGLGNQKGAVAAIEPATGRILALASTPSYDPGSFAGT  202

Query  556   TKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQ  735
             +  D+ AW  L  DP++PMLNRALR+ YPPGSTFK+VTAA A   G        T  P  
Sbjct  203   SNADQAAWKKLQDDPDQPMLNRALRQIYPPGSTFKVVTAAAALANGVVTDIDAPTGAPYP  262

Query  736   YILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-  912
             Y++PGT+TPL N +   D    ++  AM LSCN+V G +G + G D++ A A  FGFN  
Sbjct  263   YVMPGTTTPLNNDTTACDQAGLSLDEAMTLSCNSVMGYLGVQTGLDRMTAMAGNFGFNDA  322

Query  913   EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ  1092
              +  P+RA  S+F +       A+ +IGQ+DT ATPL MAMVAA  AN+G +M P LV +
Sbjct  323   RLDTPVRAARSNFDTDMNKSQLALSSIGQYDTAATPLVMAMVAAGAANDGQVMYPQLVDR  382

Query  1093  EGSA-GNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ  1269
                A G+ +         QA    TAQ+L+QLM +VV++GTG NA+IPG  VGGKTGTAQ
Sbjct  383   LTKADGSQVQLMHPSLYHQAFGAGTAQQLRQLMVNVVENGTGRNARIPGAEVGGKTGTAQ  442

Query  1270  HGQDNSGLPFAWFVSYAK-GQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAAL  1446
             HG DNSG P+AWF+++A+         VAV V    S+A  ++GG LAAPIAK++MQA L
Sbjct  443   HGVDNSGTPYAWFIAWARPSGSAAVPPVAVAVVIADSQATDVTGGGLAAPIAKSVMQAVL  502

Query  1447  GK  1452
              K
Sbjct  503   DK  504


&gt;WP_057228032.1 MULTISPECIES: penicillin-binding protein [Kitasatospora]
 KQV24303.1 penicillin-binding protein [Kitasatospora sp. Root107]
 KRB67648.1 penicillin-binding protein [Kitasatospora sp. Root187]
Length=468

 Score = 420 bits (1080),  Expect = 4e-143, Method: Compositional matrix adjust.
 Identities = 229/466 (49%), Positives = 300/466 (64%), Gaps = 4/466 (1%)
 Frame = +1

Query  58    MLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKSDFVNGLRYKYKRSW  237
             M +  +VQ  +A +  +NP N R    +YA PRGNI+VG   VT S    G RY YKR++
Sbjct  1     MGQATYVQVFRADSLDDNPANQRETIQRYAQPRGNILVGADPVTGSAPTGG-RYAYKRTY  59

Query  238   VDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDMLTGKPKQGGDVVTTI  417
              DGPM+A VTGYSSQTY  +Q+E +ED +LSGTDSRL      D +T K   GGDV TT+
Sbjct  60    TDGPMWAAVTGYSSQTYGNTQIEGVEDDLLSGTDSRLASWALWDEITRKQNPGGDVYTTL  119

Query  418   DPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKAWTALDSD  597
             +   Q+A  +GLGN+ GA  AI+P TG IL L STPSYDPG+FAG +  D+ AW  L +D
Sbjct  120   NNAAQQAAMKGLGNQTGAVAAIEPATGRILALASTPSYDPGSFAGSSTADQDAWNKLQAD  179

Query  598   PNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTSTPLINAS  777
              N+PMLNRALR+ YPPGSTFK+VTAA A   G        T  P  +++PGT+T L+N +
Sbjct  180   KNQPMLNRALRQIYPPGSTFKVVTAAAALANGVVTDIDAPTSAPYPFVMPGTTTALVNDT  239

Query  778   PTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-EVTIPIRADASHFP  954
                D    ++  AM  SCN+V G +G ++G DK+ A A+ FGFN  ++  P+RA  S+F 
Sbjct  240   SACDTPGQSLDQAMVNSCNSVMGYLGTQVGLDKMVAMAQNFGFNDAKLDTPVRAARSNFD  299

Query  955   SGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ-EGSAGNVISTHTE  1131
             +       A+ +IGQ+DT ATPL MAMVAA +ANNG++M P LV +   S G+ +     
Sbjct  300   TAMNASQVALSSIGQYDTAATPLVMAMVAAGVANNGTVMYPQLVDKLTKSDGSSVQVMQP  359

Query  1132  HQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQHGQDNSGLPFAWFV  1311
                 QA+SP  A ++QQLM  VV+ GTG +A+I G TVGGKTGTAQ G DNSG+P+AWF+
Sbjct  360   AGYRQAMSPTVAGQVQQLMTDVVETGTGRSARISGATVGGKTGTAQQGIDNSGIPYAWFI  419

Query  1312  SYAKGQDGKQVAVAVVVED-GSSEAQQISGGSLAAPIAKAMMQAAL  1446
             S+AK     QV    V      S A  ++GG LAAPIA+++MQA L
Sbjct  420   SWAKPSGSNQVPPVAVAVVIADSNATDVTGGGLAAPIARSVMQAVL  465


&gt;WP_051055920.1 penicillin-binding protein [Kitasatospora setae]
Length=474

 Score = 420 bits (1080),  Expect = 5e-143, Method: Compositional matrix adjust.
 Identities = 239/475 (50%), Positives = 307/475 (65%), Gaps = 4/475 (1%)
 Frame = +1

Query  37    LVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKSDFVNGLR  216
             ++LI+AL L+   VQ  Q     +N  N R    +YA PRGN++VGGQ VT S    G R
Sbjct  1     MLLIVALALQATRVQVFQKKELDHNSANQRATIQRYAQPRGNLLVGGQPVTGSSATGG-R  59

Query  217   YKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDMLTGKPKQG  396
             Y Y+R++ DGP+YA VTGYSSQTY  +QLE ++D +LSGTD RL      D +T + + G
Sbjct  60    YAYQRTYTDGPLYAAVTGYSSQTYGNTQLEGVDDDLLSGTDPRLAGWAVWDAVTRQQQPG  119

Query  397   GDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKA  576
             GDVVTTIDP  Q+A   GLGN+KGA  AI+P TG IL L STPSYDPG+FAG +  D+ A
Sbjct  120   GDVVTTIDPAAQRAALRGLGNQKGAVAAIEPATGRILALASTPSYDPGSFAGTSNADQAA  179

Query  577   WTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTS  756
             W  L  DP++PMLNRALR+ YPPGSTFK+VTAA A   G        T  P  Y++PGT+
Sbjct  180   WKKLQDDPDQPMLNRALRQIYPPGSTFKVVTAAAALANGVVTDIDAPTGAPYPYVMPGTT  239

Query  757   TPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-EVTIPIR  933
             TPL N +   D    ++  AM LSCN+V G +G + G D++ A A  FGFN   +  P+R
Sbjct  240   TPLNNDTTACDQAGLSLDEAMTLSCNSVMGYLGVQTGLDRMTAMAGNFGFNDARLDTPVR  299

Query  934   ADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSA-GN  1110
             A  S+F +       A+ +IGQ+DT ATPL MAMVAA  AN+G +M P LV +   A G+
Sbjct  300   AARSNFDTDMNKSQLALSSIGQYDTAATPLVMAMVAAGAANDGQVMYPQLVDRLTKADGS  359

Query  1111  VISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQHGQDNSG  1290
              +         QA    TAQ+L+QLM +VV++GTG NA+IPG  VGGKTGTAQHG DNSG
Sbjct  360   QVQLMHPSLYHQAFGAGTAQQLRQLMVNVVENGTGRNARIPGAEVGGKTGTAQHGVDNSG  419

Query  1291  LPFAWFVSYAK-GQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAALGK  1452
              P+AWF+++A+         VAV V    S+A  ++GG LAAPIAK++MQA L K
Sbjct  420   TPYAWFIAWARPSGSAAVPPVAVAVVIADSQATDVTGGGLAAPIAKSVMQAVLDK  474


&gt;WP_033819927.1 penicillin-binding protein [Kitasatospora sp. MBT63]
Length=487

 Score = 419 bits (1078),  Expect = 1e-142, Method: Compositional matrix adjust.
 Identities = 231/480 (48%), Positives = 307/480 (64%), Gaps = 4/480 (1%)
 Frame = +1

Query  16    RRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKS  195
             RR   FC++LI+AL+ +   VQ  +     +NP N R    +Y  PRGNI+V GQ VT S
Sbjct  6     RRAGTFCVLLIVALIAQATRVQVFRKDELDHNPANQRLTVQRYDQPRGNILVDGQPVTGS  65

Query  196   DFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDML  375
                 G R+ Y+R++ DGP YA VTG+SSQTY  +QLE + D +LSGTDSRL      D +
Sbjct  66    TPTGG-RFDYERTYTDGPRYAAVTGFSSQTYGNTQLEGVYDDLLSGTDSRLAGWALWDAV  124

Query  376   TGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGG  555
             + +   GGDVVTT+D   Q A  +GLG ++GA VAI+P TG IL L STPSYDP +FAG 
Sbjct  125   SRRQNPGGDVVTTLDRAAQDAAVKGLGRQQGAVVAIEPATGRILALASTPSYDPRSFAGS  184

Query  556   TKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQ  735
                D +AW  L +DP++PMLNRALR+ YPPGSTFK+VTAA A + G    P+  T  P  
Sbjct  185   GAADRRAWDRLQADPDQPMLNRALRQIYPPGSTFKVVTAAAALQDGVVSDPAAPTGAPSP  244

Query  736   YILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-  912
             Y+LPGT+T L+N +   D  +  +  AM LSCN+V G +G ++G + + + AE FGFN  
Sbjct  245   YVLPGTTTTLVNDTAACDRPDLPLDTAMVLSCNSVLGYLGVQVGQEGMVSMAENFGFNDA  304

Query  913   EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ  1092
              + +P+RA  S+F +  +P   A+ +IGQ DT ATPL MAMVAA +AN G +M P LV +
Sbjct  305   SLDVPVRAARSNFDTEMEPSQLALSSIGQFDTAATPLVMAMVAAGVANGGRVMYPQLVDR  364

Query  1093  -EGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ  1269
                S G  +         +A+  A A ++Q LM  VV+ GTG  A+IPG TVGGKTGTAQ
Sbjct  365   LTKSDGTAVQVMRPELYKEAMGAAVAGQVQGLMTDVVEQGTGRAARIPGATVGGKTGTAQ  424

Query  1270  HGQDNSGLPFAWFVSYAK-GQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAAL  1446
             HG  NSG+P+AWF+S+A+         VAV V    S+A  ++GG LAAPIA+++MQA L
Sbjct  425   HGVGNSGVPYAWFISWARPAGSADPPPVAVAVVVADSDATDVTGGRLAAPIARSVMQAVL  484


&gt;WP_051817654.1 penicillin-binding protein [Kitasatospora sp. NRRL B-11411]
Length=474

 Score = 413 bits (1062),  Expect = 2e-140, Method: Compositional matrix adjust.
 Identities = 235/475 (49%), Positives = 304/475 (64%), Gaps = 4/475 (1%)
 Frame = +1

Query  37    LVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKSDFVNGLR  216
             ++LI+AL ++   VQ  Q     +N  N R    +YA PRGN++V GQ VT S    G R
Sbjct  1     MLLIVALAVQATRVQVFQKHDLDHNSANQRATIQRYAQPRGNLLVAGQPVTGSAPTGG-R  59

Query  217   YKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDMLTGKPKQG  396
             Y YKR++ DG +YAPVTGYSSQTY  +QLE + D +LSGTD RL      D +T + + G
Sbjct  60    YAYKRTYTDGALYAPVTGYSSQTYGNTQLEGVYDDLLSGTDPRLAGWAVWDAVTRQQQPG  119

Query  397   GDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKA  576
             GDVVTTIDP  Q+A  +GLGN+KGA  AI+P TG IL L STP YDPGTFAG +  D+ A
Sbjct  120   GDVVTTIDPAAQRAAMQGLGNQKGAVAAIEPATGRILALASTPGYDPGTFAGTSAADQNA  179

Query  577   WTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTS  756
             W  L  DP++PMLNRALR+ YPPGSTFK+VTAA A   G        TD P  Y++PGT+
Sbjct  180   WKKLQDDPDQPMLNRALRQIYPPGSTFKVVTAAAALANGVVTDIEAPTDAPYPYVMPGTT  239

Query  757   TPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-EVTIPIR  933
             TPL N +   D    ++  AM LSCN+V G +G + G D++ A A+ FGFN   +  P+R
Sbjct  240   TPLNNDTSACDRAGLSLDEAMTLSCNSVMGYLGVQTGLDRMTAMAKNFGFNDARLDTPVR  299

Query  934   ADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSA-GN  1110
             A  S+F +       A+ +IGQ+DT ATPL MAMVAA  A +G +M P LV +   A G+
Sbjct  300   AARSNFDTEMNKSQLALSSIGQYDTAATPLAMAMVAAGAAADGQVMYPQLVDKLTKADGS  359

Query  1111  VISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQHGQDNSG  1290
              +         QA   A AQ+L+QLM  VV++GTG NA+IPG  VGGKTGTAQHG DNSG
Sbjct  360   QVQLMHPSLYRQAFGAAVAQQLRQLMVDVVENGTGRNARIPGAEVGGKTGTAQHGVDNSG  419

Query  1291  LPFAWFVSYAK-GQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAALGK  1452
              P+AWF+++A+         VAV V    S+A  ++GG LAAPIA+++MQ  L +
Sbjct  420   TPYAWFIAWARPAGSTAVPPVAVAVVVADSQADDVTGGGLAAPIARSVMQTVLNR  474


&gt;WP_051776935.1 penicillin-binding protein [Kitasatospora phosalacinea]
Length=474

 Score = 412 bits (1060),  Expect = 5e-140, Method: Compositional matrix adjust.
 Identities = 231/478 (48%), Positives = 310/478 (65%), Gaps = 10/478 (2%)
 Frame = +1

Query  37    LVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKSDFVNGLR  216
             ++LI+AL L+   VQ  Q     +N  N R    +Y+ PRGN++V GQ VT S    G R
Sbjct  1     MLLIVALALQATRVQVFQKDELDHNAANQRATIQRYSQPRGNLLVAGQPVTGSAETGG-R  59

Query  217   YKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDMLTGKPKQG  396
             Y Y+R++ DGP+YA VTGYSSQTY  +QLE + D +LSGTD +L      D +T + + G
Sbjct  60    YAYQRTYTDGPLYAAVTGYSSQTYGNTQLEGVYDDVLSGTDPKLAGWAVWDAVTRQQQPG  119

Query  397   GDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKA  576
             GDVVTTIDP  Q+A  +GLG++KGA  AI+P TG IL LVSTPSYDPG+FAG +  D+ A
Sbjct  120   GDVVTTIDPAAQRAAVQGLGSQKGAVAAIEPATGRILALVSTPSYDPGSFAGTSAADQNA  179

Query  577   WTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTS  756
             W  L  DP +PMLNRALR+ YPPGSTFK+VTAA A  +G        TD P  Y++PGT+
Sbjct  180   WKKLQDDPEQPMLNRALRQIYPPGSTFKVVTAAAALASGVVTDVDAPTDAPYPYVMPGTT  239

Query  757   TPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-EVTIPIR  933
             TPL N +   +    ++  AM LSCN+V G +G + G D++ A A+ FGFN   + +P+R
Sbjct  240   TPLDNDTSACNRAGLSLDEAMTLSCNSVMGYLGVQTGLDRMTAMAQDFGFNDARLDVPVR  299

Query  934   ADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ----EGS  1101
             A  S+F +       A+ +IGQ+DT ATPL MAMVAA  AN+G +M P LV +    +G+
Sbjct  300   AARSNFDTDMNQSQLALSSIGQYDTAATPLVMAMVAAGAANDGQVMSPQLVDKLTKADGT  359

Query  1102  AGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQHGQD  1281
                ++     H   QA     A++L+QLM  VV++GTG NA+IPG  VGGKTGTAQHG D
Sbjct  360   QVQLMHPALHH---QAFGAGVARQLRQLMVDVVENGTGRNARIPGAEVGGKTGTAQHGVD  416

Query  1282  NSGLPFAWFVSYAK-GQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAALGK  1452
             NSG P+AWF+++A+         VAV V    S+A  ++GG LAAP+A+++MQA L +
Sbjct  417   NSGTPYAWFIAWARPAGSTAVPPVAVAVVVADSQATDVTGGGLAAPVARSVMQAVLNR  474


&gt;WP_052840719.1 penicillin-binding protein [Kitasatospora aureofaciens]
Length=485

 Score = 412 bits (1058),  Expect = 1e-139, Method: Compositional matrix adjust.
 Identities = 232/488 (48%), Positives = 317/488 (65%), Gaps = 9/488 (2%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             + + IR  ++FC +L++AL++    VQ VQ   + +NP N R    +Y  PRG+I+VGG+
Sbjct  1     MTRNIRHAALFCALLLVALVVNAARVQIVQKPEYDDNPANRRPDIARYQQPRGDILVGGE  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
             AVT S    G   +++R++ DGPMYAP+TG++SQ Y  + LE  EDG+LSG D  L    
Sbjct  61    AVTGSRD-TGEHLRFERTYADGPMYAPITGFASQAYGTTLLEHAEDGLLSGADPMLAPLP  119

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
               + +TG    GGDVVTTID   Q+A FEGLG +KGA  A++P TG +L LVSTPSYDP 
Sbjct  120   LWNDVTGAHNPGGDVVTTIDGAAQRAAFEGLGGRKGAVAAVEPATGRVLALVSTPSYDPQ  179

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
               +G + D  + W  L+ DP+KPMLNRA+  TYPPGSTFK+VTAA A + G  +     T
Sbjct  180   LLSGNSADATRTWHRLNDDPDKPMLNRAVSRTYPPGSTFKVVTAAAALDAGVVRDLDAPT  239

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
              +PD Y LPGT T L N +  + C NA+++ A + SCNTVF K+G ++G   + A A+ F
Sbjct  240   RSPDPYTLPGTRTKLTNEA--DGCRNASLREAFEWSCNTVFAKLGVDVGVRGMTAMADAF  297

Query  901   GFNKE-VTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  1077
             GFN + + IP     S F +        + +IGQ++TRATPLQMAMVAAA+A  G +  P
Sbjct  298   GFNDDGLRIPFPVARSTFDTSVDRAQLGLSSIGQYNTRATPLQMAMVAAAVAGGGQVRSP  357

Query  1078  YLVAQEGSA-GNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGK  1254
             YLV +   A G++++        + + P+TA  L++LM  VV  GTG  A IPG TVGGK
Sbjct  358   YLVERTLRAGGSLVAAAGSRPSREVMRPSTAALLKELMTGVVDKGTGARAAIPGATVGGK  417

Query  1255  TGTAQHGQDNSGLPFAWFVSYAKGQDGK---QVAVAVVVEDGSSEAQQISGGSLAAPIAK  1425
             TGTAQHG  NSG P+AWF+++A+G DG    +VAVAVVVE  +++   +SGG LAAPIA+
Sbjct  418   TGTAQHGVGNSGKPYAWFIAWARG-DGDVEPKVAVAVVVEGSAADRGGVSGGGLAAPIAR  476

Query  1426  AMMQAALG  1449
              +M+A LG
Sbjct  477   GVMEAVLG  484


&gt;WP_051732513.1 penicillin-binding protein [Kitasatospora phosalacinea]
Length=474

 Score = 410 bits (1053),  Expect = 5e-139, Method: Compositional matrix adjust.
 Identities = 232/475 (49%), Positives = 307/475 (65%), Gaps = 4/475 (1%)
 Frame = +1

Query  37    LVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKSDFVNGLR  216
             ++LI+AL L+   VQ  Q     +N  N R    +Y+ PRGN++V GQ VT S    G R
Sbjct  1     MLLIVALALQATRVQVFQKKELDHNSANQRATIQRYSQPRGNLLVAGQPVTGSAETGG-R  59

Query  217   YKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDMLTGKPKQG  396
             Y YKR++ DG +YA VTGYSSQTY  +QLE + D +LSGTD RL      D +T + + G
Sbjct  60    YAYKRTYTDGALYAAVTGYSSQTYGNTQLEGVYDDLLSGTDPRLAGWAVWDAVTRQQQPG  119

Query  397   GDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGGTKDDEKA  576
             GDVVTTIDP  Q+A  +GLGN+KGA  AI+P TG IL L STP YDPG+FAG +  D+ A
Sbjct  120   GDVVTTIDPAAQRAATQGLGNQKGAVAAIEPATGRILALASTPGYDPGSFAGTSTADQAA  179

Query  577   WTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQYILPGTS  756
             W  L  DP++PMLNRALR+ YPPGSTFK+VTAA A   G        T  P  Y++PGT+
Sbjct  180   WEKLQDDPDQPMLNRALRQIYPPGSTFKVVTAAAALANGVVTDIDAPTGAPYPYVMPGTT  239

Query  757   TPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-EVTIPIR  933
             TPL N +   D    ++  A+ LSCN+V G +G ++G D++ A A  FGFN  ++ +P+R
Sbjct  240   TPLNNDTGACDRAGLSLDEAVTLSCNSVMGYLGVQVGLDRMTAMARNFGFNDAKLDVPVR  299

Query  934   ADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQEGSA-GN  1110
             A  ++F +       A+ +IGQ+DT ATPL MAMVAA  AN+G +M P LV +   A G+
Sbjct  300   AARANFDTDMNESQLALSSIGQYDTAATPLVMAMVAAGAANDGQVMYPQLVDKLTKADGS  359

Query  1111  VISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQHGQDNSG  1290
              +         QA   + A++LQQLM  VV++GTG NA+IPG  VGGKTGTAQHG DN+G
Sbjct  360   QVQLMHPTLYRQAFGSSVARQLQQLMVGVVENGTGRNARIPGAEVGGKTGTAQHGVDNTG  419

Query  1291  LPFAWFVSYAK-GQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAALGK  1452
              P+AWF+++A+         VAV V    S+A  ++GG LAAPIAK++MQA LG+
Sbjct  420   TPYAWFIAWARPAGSAAVPPVAVAVVVADSQADDVTGGGLAAPIAKSVMQAVLGR  474


&gt;WP_100892658.1 penicillin-binding protein [Kitasatospora sp. OK780]
Length=487

 Score = 408 bits (1048),  Expect = 4e-138, Method: Compositional matrix adjust.
 Identities = 236/482 (49%), Positives = 303/482 (63%), Gaps = 8/482 (2%)
 Frame = +1

Query  16    RRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKS  195
             RR   FCL+LI+AL  +   +Q   A +  +N  N R    +Y  PRGNI+VGG+ VT S
Sbjct  6     RRAGTFCLLLIVALAAQATKIQVFDADSLDHNAANQRLAVQRYDQPRGNILVGGRPVTGS  65

Query  196   DFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDML  375
                 G RY +KR++ DGP +A VTGYSSQTY  SQLE + D +LSGTD RL      D L
Sbjct  66    TATGG-RYDWKRTYTDGPRWAAVTGYSSQTYGNSQLEGIYDDLLSGTDDRLSGWAVWDAL  124

Query  376   TGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGG  555
             + +   GGDV TT+D   Q A  +GLG++KGA VAI+P TG IL L STPSYDPG+FAG 
Sbjct  125   SRRQNPGGDVDTTLDTDAQAAALQGLGSQKGAVVAIEPATGRILALASTPSYDPGSFAGT  184

Query  556   TKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQ  735
             +  D  AW  L +D ++PMLNRALR+ YPPGSTFK+VTAA A   G    P      P  
Sbjct  185   SAADRAAWDRLHADADQPMLNRALRQIYPPGSTFKVVTAAAALAGGVVTDPDAPVGAPSP  244

Query  736   YILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-  912
             Y+LPGT+T L+N +   D    T+  AM  SCN+V G +G + G + L A AE FGFN  
Sbjct  245   YVLPGTTTELVNDTSACDGTGITLTEAMVNSCNSVMGYLGVKTGLNGLTAMAENFGFNDA  304

Query  913   EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ  1092
              +  P+RA  S+  +       A+ AIGQ+DT ATPL MAMVAA +ANNG++M P LV +
Sbjct  305   RLDTPVRAARSNIDTTMNASQVALSAIGQYDTAATPLVMAMVAAGVANNGTVMRPQLVDR  364

Query  1093  --EGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTA  1266
                G    +   H E    +A++ + A ++QQLM  VV++GTG  A+I G TVGGKTGTA
Sbjct  365   LTRGDGTPIQLMHPE-VYRRAMNGSVAGQVQQLMVDVVENGTGRRARISGATVGGKTGTA  423

Query  1267  QHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGS--SEAQQISGGSLAAPIAKAMMQA  1440
             QHG DNSG P+AWF+S+A+  DG      V V      SEA  ++GG +AAPIA+A+MQA
Sbjct  424   QHGVDNSGTPYAWFISWAR-PDGSNAVPPVAVAVVVADSEATDVTGGGIAAPIARAVMQA  482

Query  1441  AL  1446
              L
Sbjct  483   VL  484


&gt;PKB48172.1 peptidoglycan glycosyltransferase [Kitasatospora sp. OK780]
Length=502

 Score = 408 bits (1048),  Expect = 9e-138, Method: Compositional matrix adjust.
 Identities = 236/482 (49%), Positives = 303/482 (63%), Gaps = 8/482 (2%)
 Frame = +1

Query  16    RRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKS  195
             RR   FCL+LI+AL  +   +Q   A +  +N  N R    +Y  PRGNI+VGG+ VT S
Sbjct  21    RRAGTFCLLLIVALAAQATKIQVFDADSLDHNAANQRLAVQRYDQPRGNILVGGRPVTGS  80

Query  196   DFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDML  375
                 G RY +KR++ DGP +A VTGYSSQTY  SQLE + D +LSGTD RL      D L
Sbjct  81    TATGG-RYDWKRTYTDGPRWAAVTGYSSQTYGNSQLEGIYDDLLSGTDDRLSGWAVWDAL  139

Query  376   TGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGG  555
             + +   GGDV TT+D   Q A  +GLG++KGA VAI+P TG IL L STPSYDPG+FAG 
Sbjct  140   SRRQNPGGDVDTTLDTDAQAAALQGLGSQKGAVVAIEPATGRILALASTPSYDPGSFAGT  199

Query  556   TKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQ  735
             +  D  AW  L +D ++PMLNRALR+ YPPGSTFK+VTAA A   G    P      P  
Sbjct  200   SAADRAAWDRLHADADQPMLNRALRQIYPPGSTFKVVTAAAALAGGVVTDPDAPVGAPSP  259

Query  736   YILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-  912
             Y+LPGT+T L+N +   D    T+  AM  SCN+V G +G + G + L A AE FGFN  
Sbjct  260   YVLPGTTTELVNDTSACDGTGITLTEAMVNSCNSVMGYLGVKTGLNGLTAMAENFGFNDA  319

Query  913   EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ  1092
              +  P+RA  S+  +       A+ AIGQ+DT ATPL MAMVAA +ANNG++M P LV +
Sbjct  320   RLDTPVRAARSNIDTTMNASQVALSAIGQYDTAATPLVMAMVAAGVANNGTVMRPQLVDR  379

Query  1093  --EGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTA  1266
                G    +   H E    +A++ + A ++QQLM  VV++GTG  A+I G TVGGKTGTA
Sbjct  380   LTRGDGTPIQLMHPE-VYRRAMNGSVAGQVQQLMVDVVENGTGRRARISGATVGGKTGTA  438

Query  1267  QHGQDNSGLPFAWFVSYAKGQDGKQVAVAVVVEDGS--SEAQQISGGSLAAPIAKAMMQA  1440
             QHG DNSG P+AWF+S+A+  DG      V V      SEA  ++GG +AAPIA+A+MQA
Sbjct  439   QHGVDNSGTPYAWFISWAR-PDGSNAVPPVAVAVVVADSEATDVTGGGIAAPIARAVMQA  497

Query  1441  AL  1446
              L
Sbjct  498   VL  499


&gt;WP_082346127.1 penicillin-binding protein [Kitasatospora sp. MY 5-36]
Length=502

 Score = 406 bits (1043),  Expect = 5e-137, Method: Compositional matrix adjust.
 Identities = 227/482 (47%), Positives = 306/482 (63%), Gaps = 6/482 (1%)
 Frame = +1

Query  16    RRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKS  195
             RR   FCL+L+ AL ++   VQ  QA     N  N R   ++YA PRG+I+VG   VT S
Sbjct  22    RRAGTFCLLLVAALCVQATRVQVFQAQDLDRNSANQRLTVERYAQPRGDILVGPDPVTGS  81

Query  196   DFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDML  375
             +   G RY YKR + DGP YA VTG++SQ Y  +QLE  ED +L+GTD RL   +  D +
Sbjct  82    EPTGG-RYAYKRGYTDGPTYAAVTGFASQAYGTTQLEGTEDELLTGTDGRLAGWSVWDAV  140

Query  376   TGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGG  555
             + +   GGDV TT++   Q+A   GLG++KGA  AI+P TG IL L STPSYDPG+FAG 
Sbjct  141   SRRQNPGGDVHTTLNRAAQQAAMRGLGDQKGAVAAIEPATGRILALASTPSYDPGSFAGY  200

Query  556   TKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQ  735
               DD++AW  L +D ++PMLNRALR+TYPPGSTFK+VTAA A   G    P+  T  P  
Sbjct  201   GADDQEAWNRLQADADQPMLNRALRQTYPPGSTFKVVTAAAALAAGVVTDPAAPTGAPFP  260

Query  736   YILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-  912
             Y+LPGT+TPL+N +P  D  + ++  AM  SCN+V G +G   G D++   A   GFN  
Sbjct  261   YVLPGTTTPLVNDTPACDRADLSLAAAMTASCNSVLGYLGVRTGLDRMAEMAGNLGFNDA  320

Query  913   EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ  1092
              + +P+RA  S+F +       A+ +IGQ DT ATPL MAMVAA +AN+G++M P LV +
Sbjct  321   RLDVPVRAARSNFDTRMDESQLALSSIGQFDTAATPLTMAMVAAGVANDGTVMRPQLVDR  380

Query  1093  -EGSAGNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ  1269
                S G  +         +A++PA A +++ LM  VV++GTG NA+I G  VGGKTGTAQ
Sbjct  381   LTRSDGTTVQLMKPAVYRRAMTPAVAGQVRGLMTGVVENGTGGNARIAGAVVGGKTGTAQ  440

Query  1270  HGQDNSGLPFAWFVSYA--KGQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAA  1443
             HG  NSG P+AWF+++A   G D        VV +  S A  ++GG+LAAPIA+++M+A 
Sbjct  441   HGVGNSGTPYAWFIAWAAPAGSDAVPPVAVAVVVE-DSGATDVTGGALAAPIARSVMRAV  499

Query  1444  LG  1449
             LG
Sbjct  500   LG  501


&gt;WP_003983996.1 MULTISPECIES: penicillin-binding protein [Streptomycetaceae]
 KOG67928.1 penicillin-binding protein [Kitasatospora aureofaciens]
Length=484

 Score = 395 bits (1015),  Expect = 4e-133, Method: Compositional matrix adjust.
 Identities = 249/486 (51%), Positives = 319/486 (66%), Gaps = 7/486 (1%)
 Frame = +1

Query  1     VNKPIRRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQ  180
             +N+ IRR S+F LVL++AL+L    VQ  +A  +  NP N RT   +Y+ PRGNI+VGG+
Sbjct  1     MNRYIRRASVFGLVLLVALLLNAARVQVFKADAYDANPANRRTALTRYSQPRGNILVGGR  60

Query  181   AVTKSDFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRN  360
              VT S    G R +Y+R++ +GP+YA VTGY+SQ Y  S LE  ED +LSGTD RL    
Sbjct  61    PVTGSRDSGG-RLRYERTYTEGPLYAAVTGYASQIYGTSLLEHAEDRVLSGTDPRLAPFP  119

Query  361   TLDMLTGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPG  540
                 +T + + GG+V TTID   Q+A FEGLG+KKGA  A++P+TG IL LVSTPSYDP 
Sbjct  120   LWTDITREQQPGGEVRTTIDAAAQRAAFEGLGSKKGAVAAVEPRTGKILALVSTPSYDPN  179

Query  541   TFAGGTKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVT  720
               AG  +    AW  L+    +PMLNRAL++TYPPGSTFK+VTAA A +  K       T
Sbjct  180   ELAGTGRPVTTAWDRLNHGGEQPMLNRALKQTYPPGSTFKVVTAAAALDHRKVTDLDAKT  239

Query  721   DTPDQYILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKF  900
               P  Y LPGTST L N +    C NA+++HA ++SCNTVF  +G ++G D +   AE F
Sbjct  240   GIPSPYTLPGTSTKLTNEA--GGCANASLRHAFEMSCNTVFAGLGVDVGLDGMAGTAENF  297

Query  901   GFNKE-VTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEP  1077
             GFN   + IP  A  S+F +       A+ AIGQ+DT ATPLQMAMVAAA+AN+G +  P
Sbjct  298   GFNDAGLKIPSTATRSNFDTDMNDAQLALSAIGQYDTTATPLQMAMVAAAVANDGGVRAP  357

Query  1078  YLVAQEGSA-GNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGK  1254
             YLV +   A G  +S   +  L +A+   TA++LQ+LM  VV  GTG NA I G TVGGK
Sbjct  358   YLVDKVTDADGETVSATRQRTLHRAMERDTARRLQELMTGVVTRGTGGNAAIDGATVGGK  417

Query  1255  TGTAQHGQDNSGLPFAWFVSYAK--GQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKA  1428
             TGTAQHG  N G P+AWF+S+AK  G D   VAVAVVVED +++   ISGG  AAPIA+A
Sbjct  418   TGTAQHGVHNEGTPYAWFISWAKRDGADDPAVAVAVVVEDAAADRADISGGGSAAPIARA  477

Query  1429  MMQAAL  1446
             +MQAAL
Sbjct  478   VMQAAL  483


&gt;WP_083646743.1 penicillin-binding protein [Kitasatospora sp. CB01950]
Length=501

 Score = 395 bits (1015),  Expect = 6e-133, Method: Compositional matrix adjust.
 Identities = 232/484 (48%), Positives = 308/484 (64%), Gaps = 11/484 (2%)
 Frame = +1

Query  16    RRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKS  195
             RR + FC++LI+ L ++   VQ  Q      N  N R    +YA PRGN+I G Q VT S
Sbjct  24    RRAATFCMLLIIVLAVQGTRVQVFQKKELDQNSANQRATVQRYAQPRGNLIAG-QPVTGS  82

Query  196   DFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDML  375
                 G R  Y+R++ DGP+YA VTGYSSQ Y  +QLE + D +L+GTD RL      D +
Sbjct  83    -VATGGRLAYQRTYTDGPLYAAVTGYSSQIYGNTQLEGVYDALLTGTDPRLAGWAVWDAI  141

Query  376   TGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGG  555
             T   + GGDVVTTIDP VQ+A  +GLGN+KGA  AI+P TG IL L STPSYDPG+ AG 
Sbjct  142   TRHQQPGGDVVTTIDPAVQRAAMQGLGNQKGAVAAIEPATGRILALASTPSYDPGSIAGT  201

Query  556   TKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQ  735
             T  D+ AW  L +DP++PMLNRALR+ YPPGSTFK+VTAA A   G        T  P  
Sbjct  202   T--DQAAWEKLQADPDQPMLNRALRQIYPPGSTFKVVTAAAALANGTVTDIQAPTGAPYP  259

Query  736   YILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-  912
             Y+LPGT+T L N +   +    ++  AM +SCN+V G +G + G D++ A A+ FGF+  
Sbjct  260   YVLPGTTTTLNNDTGACNQEGLSLDDAMTMSCNSVMGWLGVQTGLDRMVAMAKNFGFDDA  319

Query  913   EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ  1092
             ++ IP+RA  S+F +       A+ +IGQ++T ATPL MAMVAA  A+NG +M P LV +
Sbjct  320   KLDIPVRAARSNFDTDMNASQLALSSIGQYNTAATPLVMAMVAAGAADNGQVMYPQLVDR  379

Query  1093  EGSA-GNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ  1269
                A G  +         QA  P  A ++++LM  VV +GTG NA+IPG  VGGKTGTA+
Sbjct  380   LTKADGTQVQLMRPTLYRQAFGPGVAAQVRRLMVDVVDNGTGANAQIPGAEVGGKTGTAE  439

Query  1270  HGQDNSGLPFAWFVSYAK---GQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQA  1440
             HG DN+G P+AWF+++A+     D   VAVAVV+ D  S+A  ++GG LAAPIAK++MQ 
Sbjct  440   HGVDNTGTPYAWFIAWARPAGSTDVPPVAVAVVIAD--SQASDVTGGGLAAPIAKSVMQT  497

Query  1441  ALGK  1452
              L +
Sbjct  498   VLNR  501


&gt;KIQ64169.1 penicillin-binding protein [Kitasatospora griseola]
Length=485

 Score = 389 bits (999),  Expect = 1e-130, Method: Compositional matrix adjust.
 Identities = 229/482 (48%), Positives = 303/482 (63%), Gaps = 5/482 (1%)
 Frame = +1

Query  16    RRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKS  195
             RR + FC++LI+ L ++   VQ  Q     +N  N R    +YA PRGN+I  GQ VT S
Sbjct  6     RRAATFCMLLIVLLAVQATRVQVFQKQELDHNSANQRATIQRYAQPRGNLI-AGQPVTGS  64

Query  196   DFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDML  375
                 G R  Y+R++ DGP+YA VTGYSSQ Y  +QLE + D +L+GTD RL      D +
Sbjct  65    -VATGGRLAYRRTYTDGPLYAAVTGYSSQIYGNTQLEGVYDDLLTGTDPRLTGWAVWDAI  123

Query  376   TGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGG  555
             T   + GGDVVTTIDP VQ+A  +GLG ++GA  AI+P TG IL L STPSYDPGT AG 
Sbjct  124   TRNQRPGGDVVTTIDPAVQRAAMQGLGGQQGAVAAIEPATGRILALASTPSYDPGTIAGA  183

Query  556   TKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQ  735
                D+ AW  L +DP++PMLNRALR+ YPPGSTFK+VTAA A   G        T  P  
Sbjct  184   GAADQAAWEKLQADPDQPMLNRALRQIYPPGSTFKVVTAAAALANGTVTDIQAPTGAPFP  243

Query  736   YILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-  912
             Y++PGT+T L N +   D    ++  AM LSCN+V G +G + G D++ A A+ FGF+  
Sbjct  244   YVMPGTTTTLNNDTSACDREGLSLDEAMTLSCNSVLGWLGVQTGLDRMVAMAKNFGFDDA  303

Query  913   EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ  1092
             ++ +P+RA  S+F +       A+ +IGQ++T ATPL MAMVAA +A +G +M P LV +
Sbjct  304   KLDVPVRAARSNFDTRMNSSQLALSSIGQYNTAATPLVMAMVAAGVAADGQVMHPQLVDR  363

Query  1093  EGSA-GNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ  1269
                A G  +         QA  P  A +L++LM +VV +GTG NA+IPG  VGGKTGTA+
Sbjct  364   LTKADGTQVQLMRPALYRQAFGPGVAAELRRLMVNVVNNGTGGNAQIPGAEVGGKTGTAE  423

Query  1270  HGQDNSGLPFAWFVSYAK-GQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAAL  1446
             HG DNSG P+AWF+++A+         VAV V    S A  ++GG LAAPIAKA+MQA L
Sbjct  424   HGVDNSGTPYAWFIAWARPAGSTATPPVAVAVVVADSTATDVTGGRLAAPIAKAVMQAVL  483

Query  1447  GK  1452
              +
Sbjct  484   DR  485


&gt;KDN83954.1 penicillin-binding protein [Kitasatospora cheerisanensis KCTC 
2395]
Length=503

 Score = 387 bits (995),  Expect = 8e-130, Method: Compositional matrix adjust.
 Identities = 231/482 (48%), Positives = 305/482 (63%), Gaps = 5/482 (1%)
 Frame = +1

Query  16    RRVSIFCLVLILALMLRVNWVQGVQASTWANNPHNDRTKYDKYAYPRGNIIVGGQAVTKS  195
             RR   FC++LI+AL ++   VQ  Q     +N  N R    +YA PRGN+I G Q +T S
Sbjct  24    RRAGTFCMLLIVALAVQATRVQVFQKQELDHNSANQRAVIQRYAQPRGNLIAG-QPLTGS  82

Query  196   DFVNGLRYKYKRSWVDGPMYAPVTGYSSQTYDASQLEKLEDGILSGTDSRLFFRNTLDML  375
                 G R  ++R++ DGP+YA VTGYSSQ Y  +QLE + D +L+GTD RL      D +
Sbjct  83    KATGG-RLAHQRTYTDGPLYAAVTGYSSQLYGNTQLEGVYDDLLTGTDPRLAGWAVWDAI  141

Query  376   TGKPKQGGDVVTTIDPKVQKAGFEGLGNKKGAAVAIDPKTGAILGLVSTPSYDPGTFAGG  555
             T + + GGDVVTTIDP VQ+A  +GLG++KGA  AI+P TG IL L STPSYDPG  AG 
Sbjct  142   TRQQQPGGDVVTTIDPAVQRAAMQGLGSQKGAVAAIEPATGRILALASTPSYDPGAIAGT  201

Query  556   TKDDEKAWTALDSDPNKPMLNRALRETYPPGSTFKLVTAATAFETGKYQSPSDVTDTPDQ  735
                D+  W  L +DP++PMLNRALR+ YPPGSTFK+VTAA A   G        T  P  
Sbjct  202   GTADQDTWKRLQADPDQPMLNRALRQIYPPGSTFKVVTAAAALAAGVVTDIESPTGAPYP  261

Query  736   YILPGTSTPLINASPTEDCGNATVQHAMDLSCNTVFGKMGAELGGDKLRAQAEKFGFNK-  912
             Y++PGT+TPL N +   +    ++  AM LSCN+V G +G + G D++ A A+ FGFN  
Sbjct  262   YVMPGTTTPLTNDTSACNQEGLSLDDAMTLSCNSVMGWLGVQTGLDRMTAMAKNFGFNDA  321

Query  913   EVTIPIRADASHFPSGSKPDGTAMDAIGQHDTRATPLQMAMVAAAIANNGSLMEPYLVAQ  1092
             ++  P+RA  S+F +       A+ +IGQ+DT ATPL MAMVAA  A +G +M P LV +
Sbjct  322   KLDTPVRAARSNFDTTMNASQLALSSIGQYDTAATPLTMAMVAAGAAADGQVMYPQLVDR  381

Query  1093  EGSA-GNVISTHTEHQLSQAVSPATAQKLQQLMESVVQHGTGTNAKIPGVTVGGKTGTAQ  1269
                A G+ +         QA  P  AQ+L++LM  VVQ+GTG NA+IPG  VGGKTGTAQ
Sbjct  382   LTKADGSQVRLMHPVLYRQAFGPGVAQQLRRLMVDVVQNGTGGNARIPGAEVGGKTGTAQ  441

Query  1270  HGQDNSGLPFAWFVSYAK-GQDGKQVAVAVVVEDGSSEAQQISGGSLAAPIAKAMMQAAL  1446
             HG DN+G P+AWF+++A+         VAV V    S+A  I+GG LAAPIAKA+MQ+ L
Sbjct  442   HGVDNTGTPYAWFIAWARPAGSTATPPVAVAVVVADSQASDITGGGLAAPIAKAVMQSVL  501

Query  1447  GK  1452
              +
Sbjct  502   DR  503


  Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
    Posted date:  Mar 1, 2018  5:11 PM
  Number of letters in database: 57,881,132
  Number of sequences in database:  174,420

Lambda      K        H
   0.314    0.131    0.383 
Gapped
Lambda      K        H
   0.267   0.0410    0.140 
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 174420
Number of Hits to DB: 556788
Number of extensions: 18422
Number of successful extensions: 133
Number of sequences better than 10: 2
Number of HSP&#39;s better than 10 without gapping: 0
Number of HSP&#39;s gapped: 130
Number of HSP&#39;s successfully gapped: 2
Length of query: 1455
Length of database: 57881132
Length adjustment: 113
Effective length of query: 1342
Effective length of database: 38171672
Effective search space: 14199861984
Effective search space used: 14199861984
T: 12
A: 40
X1: 16 (7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (20.4 bits)
S2: 67 (30.4 bits)
ka-blk-alpha gapped: 1.9
ka-blk-alpha ungapped: 0.7916
ka-blk-alpha_v gapped: 42.6028
ka-blk-alpha_v ungapped: 4.96466
ka-blk-sigma gapped: 43.6362


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<h3>QUESTIONS</h3>
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<li> How does this output differ from that of the same search conducted through the web browser interface?
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<p><img src="../images/exercise.png" style="width: 100px; float: left;">
<a id="ex01"></a></p>
<h3 id="Exercise-01-(10min)">Exercise 01 (10min)<a class="anchor-link" href="#Exercise-01-(10min)">&#182;</a></h3><p>Using the sequence in the file <code>data/kitasatospora/lantibiotic.fasta</code> as a query, can you do the following?</p>
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<li> Conduct a remote `BLASTX` query against the `nr` database, restricted to <i>Kitasatospora</i> proteins
<li> Write the output to a new file called `lantibiotic_blastx_nr_kitasatospora.txt` in the output directory `output/kitasatospora`.
<li> Compare the results to the output from Exercise 01 in `notebook 03`.
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<div class=" highlight hl-ipython3"><pre><span></span><span class="c1"># SOLUTION - EXERCISE 01</span>

<span class="c1"># Load sequence of lantibiotic synthesis protein, and inspect the information</span>
<span class="n">seq</span> <span class="o">=</span> <span class="n">SeqIO</span><span class="o">.</span><span class="n">read</span><span class="p">(</span><span class="s2">&quot;data/kitasatospora/lantibiotic.fasta&quot;</span><span class="p">,</span> <span class="s2">&quot;fasta&quot;</span><span class="p">)</span>

<span class="c1"># Run the BLASTX search on the nr database, restricted to Kitasatospora spp.</span>
<span class="n">result_handle</span> <span class="o">=</span> <span class="n">NCBIWWW</span><span class="o">.</span><span class="n">qblast</span><span class="p">(</span><span class="s2">&quot;blastx&quot;</span><span class="p">,</span> <span class="s2">&quot;nr&quot;</span><span class="p">,</span> <span class="n">seq</span><span class="o">.</span><span class="n">format</span><span class="p">(</span><span class="s2">&quot;fasta&quot;</span><span class="p">),</span>
                               <span class="n">entrez_query</span><span class="o">=</span><span class="s2">&quot;kitasatospora[ORGN]&quot;</span><span class="p">,</span>
                               <span class="n">format_type</span><span class="o">=</span><span class="s2">&quot;Text&quot;</span><span class="p">)</span>

<span class="c1"># Save output to file</span>
<span class="n">outfilename</span> <span class="o">=</span> <span class="n">os</span><span class="o">.</span><span class="n">path</span><span class="o">.</span><span class="n">join</span><span class="p">(</span><span class="s1">&#39;output&#39;</span><span class="p">,</span> <span class="s1">&#39;kitasatospora&#39;</span><span class="p">,</span> <span class="s1">&#39;lantibiotic_blastx_nr_kitasatospora.txt&#39;</span><span class="p">)</span>
<span class="k">with</span> <span class="nb">open</span><span class="p">(</span><span class="n">outfilename</span><span class="p">,</span> <span class="s1">&#39;w&#39;</span><span class="p">)</span> <span class="k">as</span> <span class="n">outfh</span><span class="p">:</span>
    <span class="n">outfh</span><span class="o">.</span><span class="n">write</span><span class="p">(</span><span class="n">result_handle</span><span class="o">.</span><span class="n">read</span><span class="p">())</span>
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