diff --git a/backend/scripts/20250201_pdb_codes.txt b/backend/scripts/20250201_pdb_codes.txt new file mode 100644 index 0000000..6fa79a0 --- /dev/null +++ b/backend/scripts/20250201_pdb_codes.txt @@ -0,0 +1 @@ +9GF4, 9GF3, 9MRF, 9GF2, 9GLQ, 8VEA, 8VEZ \ No newline at end of file diff --git a/backend/scripts/data.json b/backend/scripts/data.json index b2c5070..df9b2c1 100644 --- a/backend/scripts/data.json +++ b/backend/scripts/data.json @@ -35,77 +35,77 @@ ], "subtitle":"Alpha-t-alpha, a de novo designed peptide, nmr, 23 structures", "tags":[ - "de novo design", - "helix-turn-helix" + "helix-turn-helix", + "de novo design" ], "keywords":[ - "sci", - "reported", - "restraints", - "1994", - "angle", - "results", - "dl", - "proc", - "associated", - "connected", - "helices", - "geometry", - "presented", - "jj", - "study", - "indicated", - "analyzed", - "experimental", - "peptide", + "associating", "designed", - "cd", - "generated", - "carboxylate", + "form", + "conformation", + "acad", + "initial", + "adopt", + "weaver", + "distance", + "geometry", + "show", "used", - "highly", - "orientation", - "266", + "structures", + "experimental", + "osterhout", "annealing", - "region", - "initial", - "two", - "approximately", "experimentally", "simulated", - "determined", - "dynamical", - "show", - "distance", - "acad", + "hairpin", + "approximately", + "structure", + "carboxylate", "usa", - "helical", - "structures", - "protein", - "conformation", - "adopt", - "previous", - "derived", - "refined", - "nmr", - "associating", + "dl", + "determined", + "orientation", + "1994", "dihedral", - "solution", - "structure", - "alpha", + "sci", + "results", + "cd", + "connected", + "nmr", "1995", - "hairpin", + "protein", + "study", "intended", - "turn", - "form", + "derived", + "dynamical", "20", + "indicated", + "helical", + "alpha", + "solution", + "266", + "presented", + "natl", + "highly", + "reported", + "angle", + "comprised", + "generated", "fezoui", + "turn", + "proc", + "two", + "region", "total", - "comprised", - "weaver", - "consistent", - "osterhout", - "natl" + "helices", + "jj", + "associated", + "analyzed", + "restraints", + "refined", + "peptide", + "previous", + "consistent" ], "release_date":"1998-02-04", "publication":"\"Solution structure of alpha t alpha, a helical hairpin peptide of de novo design\", Protein Sci., 6, 1869-1877", @@ -133,7 +133,7 @@ "formula_weight":4446.004, "synthesis_comment":"", "review":true, - "previous_design":"9kku", + "previous_design":"9mrf", "next_design":"1al1", "seq_thr_sim_designed":[ @@ -213,72 +213,72 @@ "synthetic protein model" ], "keywords":[ - "ridge", - "sulfate", - "factor", - "tetramer", + "leucine", + "designed", + "form", + "complex", + "12", + "leucines", "analysis", + "tetramer", + "divergence", "angstrom", - "called", - "tighter", - "noncovalent", + "shows", + "diffraction", + "ridge", + "design", "one", - "reveals", - "associated", - "helices", - "face", - "hexamer", - "crossing", - "low", + "sulfate", "bundles", - "globular", "resolution", - "ions", - "divergence", - "four", - "leucines", - "along", - "amphiphilic", - "peptide", - "designed", - "well", - "leu", - "residues", + "hydrophobic", + "formed", + "association", "suggests", - "fragment", - "crystal", - "leucine", - "consistency", - "bundle", - "12", - "hexameric", - "design", - "model", - "polypeptide", + "well", + "interior", + "r", "core", - "helical", - "protein", + "three", + "residues", + "structure", "synthetic", - "complex", - "oblique", - "diffraction", - "r", - "hydrophobic", - "interior", "helix", - "structure", - "interdigitation", - "three", - "association", - "alpha", + "called", + "polypeptide", "angles", - "computational", - "form", + "fragment", + "model", + "protein", + "globular", "ph", - "shows", + "helical", + "alpha", + "low", + "ions", + "consistency", + "tetrameric", + "factor", + "noncovalent", "discussed", - "formed", - "tetrameric" + "oblique", + "reveals", + "amphiphilic", + "along", + "crossing", + "crystal", + "helices", + "four", + "associated", + "leu", + "face", + "computational", + "bundle", + "tighter", + "interdigitation", + "peptide", + "hexameric", + "hexamer" ], "release_date":"1991-10-15", "publication":"\"Crystal structure of alpha 1: implications for protein design\", Science, 249, 543-546", @@ -392,85 +392,85 @@ "coiled coil" ], "keywords":[ - "anomalous", - "analysis", - "mad", - "specificity", + "role", + "structural", + "resolution", + "half", + "thermostable", + "experimental", "complexes", - "map", + "heterotrimeric", + "core", + "three", "strategy", - "designed", - "determine", - "associations", - "parallel", + "drive", + "study", + "illustrate", + "helical", + "electron", + "charged", + "forms", "crystal", - "basis", - "interactions", + "helices", + "chains", "multiwavelength", - "validate", - "diffraction", - "structure", - "heterotrimeric", + "engineered", + "shows", + "bundles", + "specificity", + "coordinated", + "residues", + "helix", + "polar", + "displays", "intended", - "thermostable", + "buried", "contacts", - "coiled", - "acute", - "anion", - "employed", - "determining", - "electrostatic", - "illustrate", - "seen", - "used", - "often", - "abc", - "drive", + "basis", "heterotrimer", - "trimeric", - "buried", - "preferential", - "charged", + "packing", + "abc", + "restrict", + "density", "coils", "pairs", - "coordinated", - "assembly", - "three", - "coil", - "shows", - "role", - "previously", "investigate", - "amino", - "bundles", - "resolution", - "displays", - "acids", + "uniqueness", + "critical", "design", - "apparent", - "core", - "helical", + "electrostatic", + "preferential", + "used", + "anomalous", + "acute", + "assembly", + "associations", + "seen", + "amino", + "validate", + "determining", + "map", + "parallel", + "arrangement", + "determine", + "designed", + "trimeric", + "employed", + "analysis", + "often", + "diffraction", "association", - "packing", - "structural", + "mad", + "previously", + "apparent", + "structure", + "interactions", "ion", - "restrict", - "density", - "chains", - "arrangement", - "critical", - "helices", - "study", - "experimental", - "half", - "electron", - "engineered", - "residues", - "polar", - "helix", - "uniqueness", + "anion", + "coiled", + "coil", "distinct", - "forms" + "acids" ], "release_date":"1999-02-02", "publication":"\"Crystal structure of a designed, thermostable, heterotrimeric coiled coil\", Protein Sci., 8, 84-90", @@ -573,103 +573,103 @@ ], "subtitle":"Designed peptide alpha-1, p1 form", "tags":[ - "helical bilayer; biomaterial", - "de novo protein" + "de novo protein", + "helical bilayer; biomaterial" ], "keywords":[ + "run", + "resemble", + "spaced", + "project", + "side", + "phasing", + "within", + "degrees", + "width", + "protein", + "unanticipated", + "charged", + "centers", + "composed", + "amphiphilic", + "two", + "crossing", + "crystal", + "total", + "helices", + "chains", + "face", + "adjacent", + "water", + "leucine", + "antiparallel", + "program", + "bundles", "periodic", - "bonded", + "formed", + "lysine", + "nearly", + "ideal", + "faces", + "helix", + "bilayers", + "angles", + "polar", + "opposing", + "intended", "crystallographically", - "peptide", - "spaced", - "designed", + "18", "contains", - "crystal", - "determined", + "hydrogen", + "interface", "features", - "packed", - "18", - "loosely", - "structure", - "pack", - "turn", - "intended", + "four", + "termini", + "bundle", + "peptide", "direct", - "interfaces", - "lysine", - "composed", - "face", - "opposing", - "program", - "cell", - "crossing", - "sheet", - "479", - "amphiphilic", - "parts", - "less", + "design", + "packed", + "stacked", + "30", + "overhang", + "apolar", "atoms", - "interface", - "sheets", + "plus", + "section", + "revealing", + "parts", + "cell", "alternating", - "centers", - "30", - "project", - "charged", - "bilayers", + "sheets", + "biomaterial", + "reveals", + "loosely", + "bonded", + "designed", "form", - "nearly", - "phasing", - "molecules", - "hydrogen", - "solvent", + "pack", + "one", + "interfaces", + "steep", + "rather", "yields", - "reveals", - "bundles", + "479", + "structure", "columns", - "four", - "apolar", - "run", + "lie", + "determined", + "sheet", "closely", - "steep", - "faces", - "leucine", - "stacked", + "spanning", "unit", + "molecules", + "distinct", "result", - "bundle", - "spanning", - "design", - "rather", - "biomaterial", - "resemble", - "total", - "overhang", - "lie", - "chains", - "one", - "helices", - "revealing", - "width", - "unanticipated", - "adjacent", - "two", + "turn", "glutamate", - "antiparallel", - "ideal", - "polar", - "protein", - "section", - "termini", - "plus", - "degrees", - "helix", - "water", - "angles", - "distinct", - "within", - "side", - "formed" + "solvent", + "less" ], "release_date":"1998-10-28", "publication":"\"Packed protein bilayers in the 0.90 A resolution structure of a designed alpha helical bundle\", Protein Sci., 8, 1400-1409", @@ -776,74 +776,74 @@ "coiled coil design" ], "keywords":[ - "containing", - "coiled", - "data", - "called", - "amino", - "valine", + "molecule", + "designed", + "leucine", + "form", + "designing", "threefold", - "heptad", - "trigonal", - "helices", - "crystals", - "scheme", - "bonds", + "mainly", "bundles", - "vaalesk", + "hydrophobic", "resolution", - "contrast", - "continuous", - "four", - "along", - "acid", - "among", - "vealekk", - "designed", - "trimers", - "peptides", - "mainly", - "residues", - "found", - "two", - "contains", - "parallel", - "leucine", - "crystal", + "vaalesk", "stacked", - "determined", - "bundle", - "mostly", - "based", - "crystallographic", + "trigonal", "core", - "protein", - "positions", - "alternate", - "hydrophobic", - "refined", - "propose", - "vqalekk", - "designing", - "coils", - "structure", + "based", "three", - "sequence", - "coil", + "residues", + "structure", + "called", + "acid", + "among", + "vqalekk", "within", + "determined", + "alternate", "hydrophilic", - "mediate", - "form", - "layers", + "trimers", + "bonds", + "protein", + "propose", + "contacts", + "scheme", "axis", - "total", + "amino", + "positions", + "layers", "molecules", + "continuous", + "mediate", + "interaction", + "valine", + "coiled", + "contrast", + "contains", "hydrogen", - "molecule", + "parallel", + "sequence", + "coil", + "vealekk", + "peptides", + "found", + "crystals", + "two", + "along", + "data", "related", - "contacts", - "direct", - "interaction" + "crystal", + "total", + "helices", + "four", + "coils", + "crystallographic", + "containing", + "bundle", + "refined", + "mostly", + "heptad", + "direct" ], "release_date":"1997-02-12", "publication":"\"The crystal structure of the designed trimeric coiled coil coil-VaLd: implications for engineering crystals and supramolecular assemblies\", Protein Sci., 6, 80-88", @@ -1034,50 +1034,50 @@ "alpha-helical bundle" ], "keywords":[ - "distinctive", - "layer", - "coiled", - "factor", - "consisting", - "chain", - "eight", + "leucine", + "designed", + "form", + "run", + "shows", + "design", + "unlike", + "hydrophobic", "one", - "stoichiometry", - "helices", "geometry", - "also", - "dominant", - "peptide", - "designed", + "formed", + "chain", "electrostatic", - "run", - "interface", "suggests", - "parallel", - "crystal", - "leucine", + "interior", + "side", + "contribute", + "three", + "consisting", + "dominant", + "structure", "determined", - "design", - "contributes", + "also", + "primarily", + "layer", "interactions", - "hydrophobic", + "contributes", + "layers", + "packing", + "eight", + "stabilization", + "coiled", + "factor", + "stoichiometry", + "parallel", + "interface", + "coil", + "crystal", "actually", "coils", - "interior", - "structure", - "three", + "helices", "stabilized", - "coil", - "form", - "unlike", - "layers", - "shows", - "side", - "contribute", - "packing", - "formed", - "primarily", - "stabilization" + "distinctive", + "peptide" ], "release_date":"1993-10-31", "publication":"\"Crystal structure of a synthetic triple-stranded alpha-helical bundle\", Science, 259, 1288-1293", @@ -1194,14 +1194,6 @@ "sim":0.9803000093, "partner":"3r3k" }, - { - "sim":0.9510999918, - "partner":"3h5f" - }, - { - "sim":0.9512000084, - "partner":"3h5g" - }, { "sim":0.9571999907, "partner":"1coi" @@ -1209,6 +1201,14 @@ { "sim":0.9527999759, "partner":"1fmh" + }, + { + "sim":0.9510999918, + "partner":"3h5f" + }, + { + "sim":0.9512000084, + "partner":"3h5g" } ], "struct_thr_sim_natural":[ @@ -1268,119 +1268,118 @@ ], "classification":"unknown", "classification_suggested":[ - "minimal", - "rational" + "minimal" ], "classification_suggested_reason":[ "Dek's classification: small, non-systematic, and other" ], "subtitle":"Nmr structure of a model hydrophilic amphipathic helical basic peptide", "tags":[ - "hydrophilic amphipathic basic helix peptide model", - "de novo protein" + "de novo protein", + "hydrophilic amphipathic basic helix peptide model" ], "keywords":[ - "analysis", - "amphipathic", - "zwitterionic", + "demonstrates", + "platelet", + "role", + "hydrophobic", + "sulfate", + "qapayeeaaeelaks", + "unstructured", + "presence", + "appeared", "results", - "acidic", - "us", - "studied", - "peptide", - "designed", + "folding", "cd", - "basic", - "mostly", - "based", - "interactions", - "precise", - "structure", - "hydrophilic", - "however", + "model", + "propose", + "study", + "micelles", + "working", + "ph", + "changes", + "fully", + "stabilization", "anionic", - "platelet", + "showed", + "charged", + "polypeptides", + "two", + "precise", + "secondary", + "attractive", + "effects", + "needed", "induce", - "neutral", - "membrane", + "water", + "complex", "play", - "superimposed", - "electrostatic", - "working", - "presence", + "conformational", + "however", + "cationic", "detergents", - "remains", - "used", - "demonstrates", - "necessary", - "fully", + "us", + "examine", "particularly", + "enabled", + "residues", + "studied", + "hydrophilic", + "environments", "folded", - "structures", - "charged", - "showed", - "native", - "effects", - "role", - "initiate", - "sulfate", - "qapayeeaaeelaks", - "changes", + "sds", + "dodecyl", + "factor", + "segment", + "unclear", + "peptide", + "design", + "sodium", + "superimposed", + "electrostatic", + "used", + "driven", + "groups", + "lysines", + "consistently", + "commonly", "embedded", - "cationic", - "strong", - "4", "shown", - "examine", - "lysines", - "induces", + "formation", "pf4", - "observed", - "design", - "model", - "commonly", - "hydrophobic", - "secondary", - "propose", - "nmr", + "contrast", + "zwitterionic", "sequence", - "micelles", - "segment", + "peptides", + "qapaykkaakklaes", + "mechanism", + "amphipathic", + "mostly", "could", - "formation", - "ph", - "sodium", - "dodecyl", - "appeared", - "unclear", - "stabilization", - "factor", - "one", - "groups", - "conformational", - "study", - "contrast", - "driven", - "attractive", - "human", + "designed", + "strong", + "analysis", "qaplykkiikklles", - "peptides", - "residues", - "needed", + "basic", + "one", + "observed", + "structures", + "based", + "remains", "lowered", - "two", - "environments", - "mechanism", - "qapaykkaakklaes", - "significant", - "complex", - "water", - "unstructured", - "consistently", - "enabled", - "sds", - "polypeptides", - "folding" + "structure", + "acidic", + "nmr", + "interactions", + "necessary", + "membrane", + "4", + "neutral", + "native", + "initiate", + "human", + "induces", + "significant" ], "release_date":"1999-12-10", "publication":"\"Involvement of electrostatic interactions in the mechanism of peptide folding induced by sodium dodecyl sulfate binding\", Biochemistry, 39, 8362-8373", @@ -1478,74 +1477,74 @@ ], "subtitle":"Prototype ww domain", "tags":[ - "wwprototype", "de novo protein", "protein design", + "wwprototype", "sh3 prototype" ], "keywords":[ - "35", - "stability", - "domain", + "designed", "analysis", - "monomeric", - "supports", - "network", - "amino", - "studied", - "long", - "prototype", - "putative", - "bonds", - "cerevisiae", - "stable", + "mutagenesis", + "defines", + "antiparallel", + "responsible", + "conserved", + "structural", "length", + "show", "formin", - "ions", - "conserved", - "family", - "smallest", - "fold", - "roles", - "acids", - "designed", - "kda", - "residues", - "highly", - "two", + "structures", + "putative", "absence", - "identified", - "antiparallel", - "systematic", - "folded", - "domains", "ww", - "show", - "type", + "domain", "based", - "mouse", - "structures", + "roles", + "identified", + "residues", + "structure", + "cerevisiae", + "monomeric", + "studied", + "crucial", + "fold", + "ligands", + "new", + "bonds", + "family", + "supports", + "nmr", + "disulfide", "protein", - "bound", - "using", "interactions", - "defines", - "nmr", + "network", + "folded", + "amino", + "tightly", + "stability", + "kda", + "bound", + "type", + "binding", "across", - "structure", - "responsible", + "prototype", + "ions", + "systematic", + "domains", + "highly", "sequence", - "tightly", - "ligands", - "wild", - "disulfide", + "acids", + "two", + "using", "saccharomyces", - "binding", - "structural", - "crucial", - "mutagenesis", - "new", - "range" + "stable", + "range", + "mouse", + "long", + "wild", + "35", + "smallest" ], "release_date":"2000-04-20", "publication":"\"Structural Analysis of Ww Domains and Design of a Ww Prototype\", Nat.Struct.Biol., 7, 375", @@ -1657,132 +1656,132 @@ ], "subtitle":"Crystal structure of four-helix bundle model", "tags":[ - "alpha-helical bundle", "de novo protein", + "alpha-helical bundle", "protein design" ], "keywords":[ - "reductase", - "many", - "multiple", - "use", - "bonds", - "ions", - "crystallography", - "including", - "illustrated", - "geometries", - "r2", - "adjustable", - "provide", - "storage", - "ferro", - "geometric", - "mostly", - "features", - "constructing", - "ii", + "escherichia", "probe", + "rubredoxins", + "well", + "multiple", "ribonucleotide", - "structure", - "structurally", - "escherichia", - "minimal", - "primary", - "starting", - "excellent", + "side", + "points", + "subunit", + "deviation", + "within", + "elements", + "ligands", + "parameters", + "residue", + "model", + "protein", "network", - "models", - "proteins", + "six", + "comprising", + "motif", + "r2", + "novo", + "forms", + "motifs", + "two", + "variety", + "attractive", + "secondary", + "binds", + "chains", + "using", "similar", - "de", + "geometric", + "construction", + "complex", "characterized", - "elements", - "fingers", - "processes", - "simple", - "binds", - "motif", - "hydrocarbon", + "bridging", + "formed", + "starting", + "metalloproteins", + "due", + "interior", + "ligand", + "reductase", "buried", - "df1", - "center", - "particular", - "function", + "ferro", + "hydrocarbon", + "approach", "tyr", - "motifs", - "ligands", - "comprised", - "rubredoxins", + "sites", + "proteins", + "ions", + "use", + "described", + "may", + "center", + "illustrated", "hydrogen", - "glu", - "data", - "bridging", - "associated", - "coli", - "class", + "oxygen", + "storage", + "found", + "bond", + "features", + "oxidation", + "bundle", + "required", "1", - "may", + "including", + "zinc", + "geometries", + "design", "active", - "diiron", - "monodentate", - "six", "provides", - "points", - "bundle", - "design", - "model", - "retrostructural", - "using", - "bond", - "required", - "secondary", - "stabilized", - "parameters", - "rms", "inviting", - "formation", - "cobalt", - "sites", - "lie", - "ligand", - "chains", - "oxygen", - "construction", - "approach", - "also", - "described", - "novo", - "metalloproteins", - "attractive", - "deviation", - "zinc", - "well", - "oxidation", - "found", - "subunit", - "two", - "due", + "simple", + "processes", "approximately", + "dinuclear", + "df1", + "bonds", + "also", + "monodentate", "chelating", - "iron", - "protein", - "synthesized", - "residue", - "complex", + "glu", + "formation", + "radical", + "primary", + "cobalt", "backbone", - "dinuclear", - "variety", - "interior", + "adjustable", + "coli", + "comprised", + "excellent", "noncovalently", - "extend", - "within", + "rms", + "associated", + "minimal", + "mostly", + "particular", + "models", + "diiron", + "many", + "constructing", + "structurally", + "de", + "synthesized", + "structure", + "lie", + "provide", + "crystallography", "ferritins", - "radical", - "comprising", - "side", - "formed", - "forms" + "function", + "class", + "fingers", + "retrostructural", + "extend", + "data", + "iron", + "stabilized", + "ii" ], "release_date":"2000-07-26", "publication":"\"Inaugural article: retrostructural analysis of metalloproteins: application to the design of a minimal model for diiron proteins\", Proc.Natl.Acad.Sci.USA, 97, 6298-6305", @@ -1894,97 +1893,97 @@ ], "subtitle":"Solution structure of fsd-ey, a novel peptide assuming a beta-beta-alpha fold", "tags":[ - "zinc finger", "beta-beta-alpha", + "de novo protein", "fsd-1", "designed protein", - "de novo protein" + "zinc finger" ], "keywords":[ - "28", - "propensity", - "results", - "metal", - "continued", - "peptide", - "examined", - "register", - "stabilities", - "towards", - "mutation", - "improved", - "experimentally", - "methods", - "determined", - "target", + "correlated", "score", - "instead", - "order", - "sequences", - "robustness", - "underscore", - "structure", "redesign", + "additional", + "methods", + "experimental", + "results", + "residue", "betabetaalpha", - "recently", - "predict", - "turn", - "however", - "without", - "process", - "produce", + "model", + "protein", + "six", + "underscore", + "binding", + "demonstrate", + "register", + "examined", + "accurately", + "two", + "stabilities", + "select", "characterized", + "metal", + "however", + "orbit", + "variability", + "experimentally", + "28", + "knuckle", "strongly", - "resulting", - "used", - "bonding", - "comparable", + "stability", + "propensity", "calculated", - "assumes", + "process", "improvements", - "solution", - "additional", - "second", - "hydrogen", - "need", - "stability", - "reported", - "reveals", "energies", + "hydrogen", + "predict", "tolerance", - "six", - "type", + "robustness", + "computational", + "peptide", + "zinc", + "bonding", + "need", "design", - "model", - "rubredoxin", - "negative", - "nmr", - "sequence", - "correlated", - "demonstrate", + "used", + "instead", + "produce", + "different", "finger", - "accurately", - "experimental", "fold", - "peptides", - "select", - "zinc", - "different", - "two", - "orbit", - "incorporating", - "zif268", "explore", - "binding", - "protein", - "residue", - "synthesized", + "type", + "improved", + "solution", + "incorporating", "backbone", - "computational", - "variability", + "sequence", + "reported", + "reveals", + "peptides", "ebaaagbe", - "five", - "knuckle" + "assumes", + "mutation", + "continued", + "order", + "sequences", + "synthesized", + "without", + "comparable", + "structure", + "determined", + "resulting", + "target", + "recently", + "nmr", + "rubredoxin", + "zif268", + "towards", + "negative", + "turn", + "second", + "five" ], "release_date":"2001-04-21", "publication":"\"The beta-beta-alpha fold: explorations in sequence space\", J.Mol.Biol., 307, 1411-1418", @@ -2087,156 +2086,156 @@ ], "subtitle":"Nmr solution structure of a designed heterodimeric leucine zipper", "tags":[ - "leucine zipper", - "transcription", "coiled coil", - "inter-helical ion pairing" + "transcription", + "inter-helical ion pairing", + "leucine zipper" ], "keywords":[ - "occupied", - "mhz", - "acidic", - "heptad", - "thus", - "suggest", - "close", - "connectivities", - "atom", - "designed", - "basic", - "alignment", - "dimeric", - "interchain", + "relatively", "22", - "denaturation", - "basis", - "position", - "interactions", - "8", - "conformation", - "c", - "structure", - "zipper", - "unfavorable", - "monitored", - "hydrophobicity", - "e", - "contacts", - "even", - "seven", - "coiled", - "disclose", - "chain", - "hint", - "protonation", - "h", - "almost", - "6", - "surpassed", - "electrostatic", + "defined", + "opposite", + "marginal", + "hydrophobic", "elucidated", - "ab", - "interface", - "27", - "3", - "often", - "superhelix", - "better", - "calculated", - "structures", - "upon", - "uncharged", + "pk", + "13", + "side", + "heavy", + "residue", + "degrees", + "increased", + "ph", "positions", - "mol", - "kcal", + "salt", + "across", + "close", "charged", - "coils", - "pairs", - "solution", - "likely", + "collected", + "overhauser", "circular", - "either", - "coil", - "form", - "homonuclear", - "investigate", - "stability", - "twist", - "salt", - "glu", - "interhelical", - "data", - "maximum", - "u", - "functional", - "defined", "contact", - "800", - "apolar", + "27", + "surpassed", + "stable", + "chains", + "gained", + "g", + "either", + "monitored", + "heterodimeric", + "conformation", + "terms", + "highest", + "comparison", + "due", + "dimer", + "almost", + "thus", "bridges", - "overhauser", - "increased", - "1", - "titration", + "residues", + "50", + "unfavorable", + "helix", + "charge", + "denaturation", + "contacts", + "basis", + "stability", + "20", + "calculated", + "packing", + "occupied", "29", - "4", + "2", "may", - "dimer", - "g", - "collected", + "entirely", + "twist", + "interface", + "suggest", + "zipper", + "15", + "ensemble", + "coils", "stabilize", - "observed", - "comparison", - "hydrophobic", - "nmr", - "across", + "e", + "homonuclear", + "interhelical", + "pairs", + "1", + "investigate", + "heptad", + "hint", + "values", + "c", + "superhelix", "energy", - "formation", - "ph", - "ensemble", - "heavy", - "opposite", - "packing", - "ion", - "range", - "13", - "deltag", + "chain", + "electrostatic", + "even", + "functional", + "kcal", + "apolar", "consisting", - "chains", - "entirely", - "groups", - "values", - "stable", - "highest", - "pk", + "approximately", "experiments", + "atom", + "groups", + "hydrophobicity", + "mol", + "solution", + "formation", + "ab", + "glu", + "backbone", + "upon", + "maximum", "peptides", - "charge", - "heterodimeric", - "residues", - "reveal", + "800", "unfolded", - "terms", - "due", - "approximately", - "50", + "range", + "connectivities", + "reveal", + "designed", + "form", + "rmsd", + "often", "populate", + "h", + "basic", + "titration", + "6", + "u", + "disclose", + "observed", + "structures", + "protonation", + "3", + "37", "partial", - "residue", - "15", - "2", - "marginal", - "degrees", - "backbone", - "helix", - "relatively", - "contribution", - "20", - "gained", - "side", + "likely", + "structure", + "acidic", + "nmr", + "ion", + "interactions", + "mhz", + "deltag", + "4", + "uncharged", + "coiled", + "coil", "dichroism", - "37", - "rmsd" + "seven", + "interchain", + "position", + "data", + "contribution", + "alignment", + "better", + "8", + "dimeric" ], "release_date":"2000-11-01", "publication":"\"Interhelical ion pairing in coiled coils: solution structure of a heterodimeric leucine zipper and determination of pKa values of Glu side chains\", Biochemistry, 39, 12804-12818", @@ -2333,79 +2332,79 @@ "novel sequence" ], "keywords":[ - "stereochemical", - "library", - "compatibility", - "domain", - "constraints", - "finger", - "excellent", - "magnetic", - "amino", - "identity", - "solved", - "entire", - "chemical", - "combinatorial", - "low", - "described", - "search", - "experimental", - "acid", - "1", "designed", + "search", + "demonstrates", + "identity", + "design", + "sequences", + "shows", + "structural", "spectroscopy", - "zinc", - "perform", - "validation", - "10", + "methods", + "experimental", "used", - "functions", - "demonstrates", "suggests", "agreement", + "first", + "possible", + "screen", + "domain", + "based", + "potential", + "finger", + "automated", + "structure", + "acid", "unbiased", + "polypeptide", + "immense", + "betabetaalpha", + "contexts", + "functions", + "library", + "target", + "various", + "protein", + "magnetic", + "amino", + "known", + "x", + "low", "fully", "motif", - "nuclear", - "methods", - "27", - "automated", + "algorithm", "blast", + "solution", "quantitative", - "potential", - "target", - "result", - "based", - "design", - "sequences", - "polypeptide", - "contexts", - "protein", - "full", - "required", + "described", "backbone", - "solution", - "structure", - "resonance", + "stereochemical", + "constraints", + "combinatorial", "sequence", - "various", + "resonance", + "compatibility", + "solved", + "forms", + "excellent", + "result", + "27", + "perform", + "entire", + "chemical", + "nuclear", + "compact", "physical", - "betabetaalpha", + "full", + "10", + "validation", + "indicates", "computational", - "screen", - "x", - "immense", - "shows", - "known", - "first", + "required", + "1", "novel", - "possible", - "indicates", - "structural", - "forms", - "algorithm", - "compact" + "zinc" ], "release_date":"1997-11-12", "publication":"\"De novo protein design: fully automated sequence selection\", Science, 278, 82-87", @@ -2506,83 +2505,83 @@ "subtitle":"Full sequence design 1 (fsd-1) of beta beta alpha motif, nmr, minimized average structure", "tags":[ "computational design", - "beta beta alpha motif", - "novel sequence" + "novel sequence", + "beta beta alpha motif" ], "keywords":[ - "stereochemical", - "library", - "compatibility", - "domain", - "constraints", - "finger", - "excellent", - "magnetic", - "amino", - "identity", - "solved", - "entire", - "chemical", - "combinatorial", - "low", - "described", - "search", - "experimental", - "acid", - "1", "designed", + "search", + "demonstrates", + "identity", + "design", + "sequences", + "shows", + "structural", "spectroscopy", - "zinc", - "perform", - "validation", - "10", + "methods", + "experimental", "used", - "functions", - "demonstrates", "suggests", "agreement", + "first", + "possible", + "screen", + "domain", + "based", + "potential", + "finger", + "automated", + "structure", + "acid", "unbiased", + "polypeptide", + "immense", + "betabetaalpha", + "contexts", + "functions", + "library", + "target", + "various", + "protein", + "magnetic", + "amino", + "known", + "x", + "low", "fully", "motif", - "nuclear", - "methods", - "27", - "automated", + "algorithm", "blast", + "solution", "quantitative", - "potential", - "target", - "result", - "based", - "design", - "sequences", - "polypeptide", - "contexts", - "protein", - "full", - "required", + "described", "backbone", - "solution", - "structure", - "resonance", + "stereochemical", + "constraints", + "combinatorial", "sequence", - "various", + "resonance", + "compatibility", + "solved", + "forms", + "excellent", + "result", + "27", + "perform", + "entire", + "chemical", + "nuclear", + "compact", "physical", - "betabetaalpha", + "full", + "10", + "validation", + "indicates", "computational", - "screen", - "x", - "immense", - "shows", - "known", - "first", + "required", + "1", "novel", - "possible", - "indicates", - "structural", - "forms", - "algorithm", - "compact" + "zinc" ], "release_date":"1998-01-28", "publication":"\"De novo protein design: fully automated sequence selection\", Science, 278, 82-87", @@ -2699,75 +2698,75 @@ ], "subtitle":"Crystal structure of a domain swapped dimer", "tags":[ - "designed three helix bundle", - "de novo protein" + "de novo protein", + "designed three helix bundle" ], "keywords":[ - "3d", - "domain", - "aid", - "oligomers", - "monomeric", - "one", - "topology", - "proteins", - "studied", - "rise", - "conditions", - "intermolecular", - "higher", - "scattering", + "designed", + "form", + "dimers", + "demonstrates", + "individual", + "order", + "design", + "dynamic", "bundles", + "one", + "structural", + "whose", "resolution", - "contrast", - "intramolecularly", - "crystallography", - "fibrils", - "less", - "designed", - "trimers", - "consequences", - "electron", + "topology", + "principles", + "structures", "analogs", - "demonstrates", "dimer", - "shown", - "two", - "interact", + "intermolecular", + "oligomers", + "domain", "intermolecularly", - "dimers", - "thoroughly", - "state", - "determined", - "folded", - "biomaterials", - "domains", - "several", - "light", - "design", - "order", + "oligomeric", + "structure", + "monomeric", + "studied", + "consequences", "gives", - "individual", - "whose", - "structures", + "trimers", + "determined", + "crystallography", "interactions", "protein", - "microscopy", - "dynamic", - "identical", - "structure", - "stabilized", - "predict", - "form", - "formation", - "oligomeric", - "principles", + "light", + "state", + "folded", + "shown", "known", + "interact", + "proteins", + "electron", + "fibrils", + "formation", "molecules", - "structural", - "swapping", + "conditions", + "several", + "thoroughly", + "microscopy", + "contrast", + "scattering", + "domains", + "predict", "forms", - "whereas" + "identical", + "two", + "3d", + "whereas", + "higher", + "swapping", + "biomaterials", + "less", + "stabilized", + "intramolecularly", + "rise", + "aid" ], "release_date":"2001-02-21", "publication":"\"Design of three-dimensional domain-swapped dimers and fibrous oligomers\", Proc.Natl.Acad.Sci.USA, 98, 1404-1409", @@ -2866,65 +2865,65 @@ ], "subtitle":"23-residue designed metal-free peptide based on the zinc finger domains, nmr, 35 structures", "tags":[ - "growth response protein", "de novo protein design", - "supersecondary motif" + "supersecondary motif", + "growth response protein" ], "keywords":[ - "sites", - "availability", "analysis", + "defined", + "design", "require", - "obtained", + "beta", + "metal", + "hydrophobic", + "structural", + "development", + "key", "aid", + "feature", + "reproduced", "final", - "incorporation", - "magnetic", "functional", - "proteins", - "reveals", - "architecture", - "defined", - "process", - "metal", - "ions", - "feature", + "absence", + "core", + "hairpin", "bridges", + "helix", + "availability", + "polypeptide", "template", - "fingers", - "together", - "zinc", - "small", + "disulfide", + "protein", + "magnetic", "shown", - "absence", - "nuclear", + "type", + "proteins", + "sites", "generally", + "alpha", + "process", + "stabilization", + "formation", + "ions", + "together", + "fingers", + "architecture", "domains", + "polypeptides", + "sequence", + "resonance", + "small", + "reveals", + "turn", "implications", - "ii", - "design", + "nuclear", + "incorporation", "iterative", - "polypeptide", - "type", - "core", - "protein", - "hydrophobic", - "development", - "helix", - "resonance", - "sequence", "held", - "alpha", - "reproduced", - "beta", - "turn", - "key", - "hairpin", - "formation", - "disulfide", - "polypeptides", - "structural", - "stabilization" + "obtained", + "zinc", + "ii" ], "release_date":"1997-03-12", "publication":"\"Design of a monomeric 23-residue polypeptide with defined tertiary structure\", Science, 271, 342-345", @@ -3012,7 +3011,8 @@ ], "classification":"unknown", "classification_suggested":[ - "minimal" + "minimal", + "rational" ], "classification_suggested_reason":[ "Dek's classification: small, non-systematic, and other" @@ -3020,86 +3020,86 @@ "subtitle":"Crystal structure of a de novo designed trimeric coiled-coil peptide", "tags":[ "trimer", - "de novo protein", "coiled coil", + "de novo design", "alpha-helix", - "de novo design" + "de novo protein" ], "keywords":[ - "analytical", - "stability", - "salt", - "coiled", - "100", + "trimer", + "complex", + "conformation", + "interestingly", "molecular", + "deduced", + "responsible", "regularity", - "network", - "buffer", - "represents", - "clarify", - "conditions", - "thus", - "details", - "unique", - "globule", + "design", + "shows", + "recognition", + "structural", + "atomic", + "show", + "spectroscopy", + "principles", + "tinder", + "simplicity", + "used", "de", - "novo", - "oligomerization", + "clarify", "rational", - "intrahelical", - "trimer", - "increasing", + "molten", + "strength", + "dimer", + "represents", + "thus", + "relative", "bridges", - "crystallography", - "attractive", - "peptide", - "ultracentrifugation", - "spectroscopy", - "switch", - "strength", - "used", - "highly", - "dimer", - "physiological", - "dimeric", - "two", - "shown", - "recognition", - "system", - "ionic", - "state", - "deduced", - "show", - "design", - "interestingly", + "structure", + "intrahelical", + "details", + "folding", "model", - "characterization", - "supported", + "crystallography", "interactions", "protein", + "network", + "oligomerization", + "state", + "shown", + "stability", + "salt", + "characterization", + "conditions", + "coiled", + "ionic", + "novo", + "analytical", "upon", - "assumes", - "conformation", - "complex", - "tinder", - "describe", - "atomic", - "responsible", - "stabilized", - "structure", - "molten", - "correctness", - "motifs", - "circular", + "supported", + "globule", + "highly", "coil", "conveniently", - "shows", - "simplicity", - "principles", "dichroism", - "folding", - "relative", - "structural" + "system", + "circular", + "motifs", + "buffer", + "physiological", + "two", + "switch", + "attractive", + "describe", + "correctness", + "assumes", + "unique", + "100", + "increasing", + "ultracentrifugation", + "stabilized", + "peptide", + "dimeric" ], "release_date":"2001-03-14", "publication":"\"Design of a minimal protein oligomerization domain by a structural approach\", Protein Sci., 9, 2294-2301", @@ -3188,12 +3188,19 @@ "classification_suggested":[ "engineered", "rational", + "rational", "computational", "physics-based", - "computational", "consensus", + "computational", "consensus", - "rational" + "rational", + "computational", + "physics-based", + "rational", + "computational", + "physics-based", + "consensus" ], "classification_suggested_reason":[ "Dek's classification: engineered", @@ -3205,61 +3212,61 @@ "three stranded antiparallel beta-sheet mini-protein motif de novo protein design" ], "keywords":[ - "modification", + "form", + "surface", "analysis", - "composed", - "structured", - "valuable", - "final", + "naturally", + "design", + "modification", + "hydrophobic", "topology", + "packed", + "provides", + "creation", "loops", - "additionally", - "represents", - "subsequent", + "final", "generations", - "bonds", + "yet", + "represents", + "core", + "based", + "three", + "toxin", + "structured", + "structure", "report", - "changes", + "bonds", + "new", + "additionally", + "target", + "model", + "th", + "disulfide", + "insight", + "protein", "study", "globular", - "four", - "insight", - "small", - "yet", - "compensatory", + "tightly", + "changes", + "valuable", + "hand", "motif", - "compact", - "system", - "occurring", - "target", - "provides", - "result", + "formation", "several", - "based", - "design", "produced", - "core", - "creation", - "model", - "predominantly", - "naturally", - "protein", - "hand", - "packed", - "hydrophobic", - "surface", - "structure", - "three", - "water", - "tightly", - "motifs", + "subsequent", + "system", + "small", "distinct", - "form", - "formation", - "disulfide", - "th", - "toxin", - "new" + "motifs", + "composed", + "result", + "compensatory", + "compact", + "predominantly", + "four", + "occurring", + "water" ], "release_date":"2001-04-11", "publication":"\"Design of a discretely folded mini-protein motif with predominantly beta-structure\", Nat.Struct.Biol., 8, 535-539", @@ -3346,12 +3353,11 @@ "classification_suggested":[ "engineered", "rational", + "rational", "computational", "physics-based", - "computational", - "consensus", "consensus", - "rational", + "computational", "consensus" ], "classification_suggested_reason":[ @@ -3364,61 +3370,61 @@ "de novo protein design three-stranded beta-sheet mini-protein motif th motif" ], "keywords":[ - "modification", + "form", + "surface", "analysis", - "composed", - "structured", - "valuable", - "final", + "naturally", + "design", + "modification", + "hydrophobic", "topology", + "packed", + "provides", + "creation", "loops", - "additionally", - "represents", - "subsequent", + "final", "generations", - "bonds", + "yet", + "represents", + "core", + "based", + "three", + "toxin", + "structured", + "structure", "report", - "changes", + "bonds", + "new", + "additionally", + "target", + "model", + "th", + "disulfide", + "insight", + "protein", "study", "globular", - "four", - "insight", - "small", - "yet", - "compensatory", + "tightly", + "changes", + "valuable", + "hand", "motif", - "compact", - "system", - "occurring", - "target", - "provides", - "result", + "formation", "several", - "based", - "design", "produced", - "core", - "creation", - "model", - "predominantly", - "naturally", - "protein", - "hand", - "packed", - "hydrophobic", - "surface", - "structure", - "three", - "water", - "tightly", - "motifs", + "subsequent", + "system", + "small", "distinct", - "form", - "formation", - "disulfide", - "th", - "toxin", - "new" + "motifs", + "composed", + "result", + "compensatory", + "compact", + "predominantly", + "four", + "occurring", + "water" ], "release_date":"2001-04-11", "publication":"\"Design of a discretely folded mini-protein motif with predominantly beta-structure\", Nat.Struct.Biol., 8, 535-539", @@ -3505,9 +3511,9 @@ "classification_suggested":[ "engineered", "rational", + "rational", "computational", "physics-based", - "computational", "consensus" ], "classification_suggested_reason":[ @@ -3520,61 +3526,61 @@ "de novo protein design three-stranded beta-sheet mini-protein motif th motif" ], "keywords":[ - "modification", + "form", + "surface", "analysis", - "composed", - "structured", - "valuable", - "final", + "naturally", + "design", + "modification", + "hydrophobic", "topology", + "packed", + "provides", + "creation", "loops", - "additionally", - "represents", - "subsequent", + "final", "generations", - "bonds", + "yet", + "represents", + "core", + "based", + "three", + "toxin", + "structured", + "structure", "report", - "changes", + "bonds", + "new", + "additionally", + "target", + "model", + "th", + "disulfide", + "insight", + "protein", "study", "globular", - "four", - "insight", - "small", - "yet", - "compensatory", + "tightly", + "changes", + "valuable", + "hand", "motif", - "compact", - "system", - "occurring", - "target", - "provides", - "result", + "formation", "several", - "based", - "design", "produced", - "core", - "creation", - "model", - "predominantly", - "naturally", - "protein", - "hand", - "packed", - "hydrophobic", - "surface", - "structure", - "three", - "water", - "tightly", - "motifs", + "subsequent", + "system", + "small", "distinct", - "form", - "formation", - "disulfide", - "th", - "toxin", - "new" + "motifs", + "composed", + "result", + "compensatory", + "compact", + "predominantly", + "four", + "occurring", + "water" ], "release_date":"2001-04-11", "publication":"\"Design of a discretely folded mini-protein motif with predominantly beta-structure\", Nat.Struct.Biol., 8, 535-539", @@ -3672,12 +3678,6 @@ "classification":"unknown", "classification_suggested":[ "engineered", - "rational", - "computational", - "physics-based", - "computational", - "consensus", - "consensus", "rational" ], "classification_suggested_reason":[ @@ -3690,61 +3690,61 @@ "beta-hairpin" ], "keywords":[ - "library", - "structured", - "results", - "build", - "deconvolution", - "population", + "templates", "defined", - "combinatorial", - "approach", - "resulted", - "higher", + "shows", + "sequences", + "functionality", + "show", + "identification", + "30", "de", - "stable", - "solutions", - "linear", - "four", + "starting", + "used", + "approaches", + "around", + "selected", "70", + "structured", + "structure", "fold", - "peptide", - "peptides", - "percentage", + "deconvolution", + "solutions", + "results", + "library", + "complexity", + "nmr", + "plain", + "build", + "linear", + "approach", + "positions", + "20", "4", - "used", - "highly", - "approaches", + "reduced", + "resulted", + "showed", "36", + "combinatorial", + "sequence", + "buffered", + "dichroism", + "highly", + "population", + "circular", + "peptides", "two", + "present", "evolve", - "obtain", - "show", + "stable", + "higher", + "four", "introduced", - "sequences", - "reduced", - "functionality", - "30", - "positions", - "present", + "percentage", "using", - "templates", - "nmr", - "complexity", - "structure", - "showed", - "sequence", - "circular", - "buffered", + "peptide", "could", - "20", - "shows", - "dichroism", - "plain", - "around", - "starting", - "selected", - "identification" + "obtain" ], "release_date":"2001-10-17", "publication":"\"Combinatorial approaches: a new tool to search for highly structured beta-hairpin peptides\", Proc.Natl.Acad.Sci.USA, 99, 614-619", @@ -3857,107 +3857,107 @@ ], "subtitle":"Crystal structure of four-helix bundle model", "tags":[ - "alpha-helical bundle", "de novo protein", + "alpha-helical bundle", "protein design" ], "keywords":[ - "facile", - "eventual", - "dimethyl", - "sulfoxide", + "pavone", + "acad", + "engineering", + "hydrophobic", + "cavity", + "derivative", + "well", + "summa", + "patterned", "bridge", + "sci", "diferric", + "protein", + "sulfoxide", + "next", + "entry", + "pair", + "essential", + "site", + "novo", + "forms", + "two", + "channel", + "crystal", + "attractive", + "uncover", + "water", + "leucine", + "construction", + "complex", + "occupy", + "taken", + "shows", "metal", - "ions", + "however", "determination", - "metalloenzyme", - "contains", - "smaller", - "crystal", - "features", - "ii", - "next", - "acad", - "catalytically", - "bind", "access", - "structure", + "furthermore", + "overall", + "step", + "residues", + "functions", "intended", - "however", - "degrado", - "molecule", - "aromatic", - "acetate", + "bind", + "approach", "proteins", - "ligating", - "de", - "azide", - "2000", - "indeed", - "entry", - "substrate", + "ions", + "blocked", + "described", + "degrado", + "center", + "agrees", + "contains", "small", - "step", - "furthermore", - "cavity", "97", - "df1", - "center", - "essential", - "derivative", - "dimetal", - "form", - "shows", - "molecules", - "previously", - "prevent", - "sci", - "replacement", - "taken", "proc", - "blocked", - "occupy", - "class", + "dimethyl", + "features", + "required", + "molecule", + "catalytically", + "design", + "metalloenzyme", + "df2", + "indeed", "active", - "functions", - "shown", - "leucine", - "engineering", "provides", - "design", - "required", - "hydrophobic", - "l13", + "substrate", + "prevent", + "dinuclear", + "df1", "lombardi", - "patterned", - "overall", - "construction", + "shown", + "dimanganous", + "l13", + "ii", + "form", "randaccio", - "approach", - "described", - "novo", - "monatomic", - "attractive", - "channel", - "pavone", - "well", - "residues", - "two", + "aromatic", + "ligating", + "2000", + "de", "geremia", - "uncover", - "df2", - "protein", - "complex", - "dinuclear", - "agrees", - "water", - "dimanganous", - "summa", - "site", - "pair", - "forms", - "natl" + "previously", + "structure", + "monatomic", + "azide", + "class", + "molecules", + "dimetal", + "eventual", + "natl", + "smaller", + "acetate", + "replacement", + "facile" ], "release_date":"2002-01-16", "publication":"\"Toward the de novo design of a catalytically active helix bundle: a substrate-accessible carboxylate-bridged dinuclear metal center\", J.Am.Chem.Soc., 123, 12749-12757", @@ -3995,20 +3995,20 @@ ], "struct_thr_sim_designed":[ { - "sim":0.986800015, - "partner":"1ovv" + "sim":0.9825000167, + "partner":"1lt1" }, { - "sim":0.9872999787, - "partner":"1jmb" + "sim":0.986800015, + "partner":"1ovv" }, { "sim":0.9764999747, "partner":"1ec5" }, { - "sim":0.9825000167, - "partner":"1lt1" + "sim":0.9872999787, + "partner":"1jmb" }, { "sim":0.9721000195, @@ -4094,107 +4094,107 @@ ], "subtitle":"Crystal structure of four-helix bundle model", "tags":[ - "alpha-helical bundle", "de novo protein", + "alpha-helical bundle", "protein design" ], "keywords":[ - "facile", - "eventual", - "dimethyl", - "sulfoxide", + "pavone", + "acad", + "engineering", + "hydrophobic", + "cavity", + "derivative", + "well", + "summa", + "patterned", "bridge", + "sci", "diferric", + "protein", + "sulfoxide", + "next", + "entry", + "pair", + "essential", + "site", + "novo", + "forms", + "two", + "channel", + "crystal", + "attractive", + "uncover", + "water", + "leucine", + "construction", + "complex", + "occupy", + "taken", + "shows", "metal", - "ions", + "however", "determination", - "metalloenzyme", - "contains", - "smaller", - "crystal", - "features", - "ii", - "next", - "acad", - "catalytically", - "bind", "access", - "structure", + "furthermore", + "overall", + "step", + "residues", + "functions", "intended", - "however", - "degrado", - "molecule", - "aromatic", - "acetate", + "bind", + "approach", "proteins", - "ligating", - "de", - "azide", - "2000", - "indeed", - "entry", - "substrate", + "ions", + "blocked", + "described", + "degrado", + "center", + "agrees", + "contains", "small", - "step", - "furthermore", - "cavity", "97", - "df1", - "center", - "essential", - "derivative", - "dimetal", - "form", - "shows", - "molecules", - "previously", - "prevent", - "sci", - "replacement", - "taken", "proc", - "blocked", - "occupy", - "class", + "dimethyl", + "features", + "required", + "molecule", + "catalytically", + "design", + "metalloenzyme", + "df2", + "indeed", "active", - "functions", - "shown", - "leucine", - "engineering", "provides", - "design", - "required", - "hydrophobic", - "l13", + "substrate", + "prevent", + "dinuclear", + "df1", "lombardi", - "patterned", - "overall", - "construction", + "shown", + "dimanganous", + "l13", + "ii", + "form", "randaccio", - "approach", - "described", - "novo", - "monatomic", - "attractive", - "channel", - "pavone", - "well", - "residues", - "two", + "aromatic", + "ligating", + "2000", + "de", "geremia", - "uncover", - "df2", - "protein", - "complex", - "dinuclear", - "agrees", - "water", - "dimanganous", - "summa", - "site", - "pair", - "forms", - "natl" + "previously", + "structure", + "monatomic", + "azide", + "class", + "molecules", + "dimetal", + "eventual", + "natl", + "smaller", + "acetate", + "replacement", + "facile" ], "release_date":"2002-01-16", "publication":"\"Toward the de novo design of a catalytically active helix bundle: a substrate-accessible carboxylate-bridged dinuclear metal center\", J.Am.Chem.Soc., 123, 12749-12757", @@ -4310,67 +4310,67 @@ ], "subtitle":"B4dimer: a de novo designed eight-stranded beta-sheet assembled using a disulfide bond", "tags":[ - "eight-stranded beta-sheet", "de novo protein design", "de novo protein", - "disulfide bond" + "disulfide bond", + "eight-stranded beta-sheet" ], "keywords":[ - "generation", - "data", - "considerable", - "results", - "strands", - "suggesting", - "bridge", - "strand", - "reveals", - "described", - "strategy", - "single", - "appropriately", - "cluster", - "overhauser", - "peptide", "open", - "nucleated", - "dimer", - "cys", - "nuclear", - "symmetric", - "determined", - "outer", - "content", - "comparison", + "effective", + "generation", + "involves", "design", + "hairpins", "sequences", - "characterization", - "positioned", + "hydrophobic", + "latter", + "single", + "methanol", + "dimer", "oxidative", + "precursor", + "enhancement", + "structure", "synthetic", + "positioned", + "results", + "determined", + "frayed", "residue", - "using", - "firmly", - "center", - "hydrophobic", + "strategy", "successive", - "effective", + "bridge", + "content", "nmr", - "structure", - "involves", - "establish", - "water", - "hairpins", - "stabilized", - "effects", - "frayed", - "precursor", "disulfide", - "latter", - "enhancement", - "methanol", + "symmetric", "dimerization", - "stabilization" + "cluster", + "stabilization", + "characterization", + "outer", + "cys", + "strands", + "described", + "considerable", + "center", + "strand", + "overhauser", + "nucleated", + "reveals", + "suggesting", + "nuclear", + "appropriately", + "establish", + "data", + "firmly", + "effects", + "using", + "stabilized", + "peptide", + "comparison", + "water" ], "release_date":"2002-06-12", "publication":"\"Design and construction of an open multistranded beta-sheet polypeptide stabilized by a disulfide bridge\", J.Am.Chem.Soc., 124, 4987-4994", @@ -4459,7 +4459,8 @@ ], "classification":"unknown", "classification_suggested":[ - "minimal" + "minimal", + "rational" ], "classification_suggested_reason":[ "Dek's classification: small, non-systematic, and other" @@ -4468,65 +4469,65 @@ "tags":[ "de novo protein design", "de novo protein", - "disulfide bond", - "four-stranded beta-sheet" + "four-stranded beta-sheet", + "disulfide bond" ], "keywords":[ - "generation", - "data", - "considerable", - "results", - "strands", - "suggesting", - "bridge", - "strand", - "reveals", - "described", - "strategy", - "single", - "appropriately", - "cluster", - "overhauser", - "peptide", "open", - "nucleated", - "dimer", - "cys", - "nuclear", - "symmetric", - "determined", - "outer", - "content", - "comparison", + "effective", + "generation", + "involves", "design", + "hairpins", "sequences", - "characterization", - "positioned", + "hydrophobic", + "latter", + "single", + "methanol", + "dimer", "oxidative", + "precursor", + "enhancement", + "structure", "synthetic", + "positioned", + "results", + "determined", + "frayed", "residue", - "using", - "firmly", - "center", - "hydrophobic", + "strategy", "successive", - "effective", + "bridge", + "content", "nmr", - "structure", - "involves", - "establish", - "water", - "hairpins", - "stabilized", - "effects", - "frayed", - "precursor", "disulfide", - "latter", - "enhancement", - "methanol", + "symmetric", "dimerization", - "stabilization" + "cluster", + "stabilization", + "characterization", + "outer", + "cys", + "strands", + "described", + "considerable", + "center", + "strand", + "overhauser", + "nucleated", + "reveals", + "suggesting", + "nuclear", + "appropriately", + "establish", + "data", + "firmly", + "effects", + "using", + "stabilized", + "peptide", + "comparison", + "water" ], "release_date":"2002-06-12", "publication":"\"Design and construction of an open multistranded beta-sheet polypeptide stabilized by a disulfide bridge\", J.Am.Chem.Soc., 124, 4987-4994", @@ -4637,69 +4638,69 @@ "beta-hairpin" ], "keywords":[ - "limit", - "stability", - "seven", - "data", - "longer", - "strands", - "one", - "results", - "strand", - "proteins", - "aqueous", - "use", - "elucidating", - "suggest", - "stable", - "embedded", - "length", - "fold", - "examined", - "lengthening", - "peptides", "designed", - "may", - "would", "example", - "residues", - "lengthened", - "useful", - "become", + "antiparallel", + "sequences", + "one", + "structural", + "probe", + "length", + "additional", + "show", "extension", - "specific", + "lengthened", "examine", - "antiparallel", - "folded", + "effect", "becomes", - "several", - "show", - "impossible", - "model", - "sequences", - "autonomously", + "residues", + "specific", + "preferences", + "fold", + "elucidating", + "grow", + "nine", "lead", + "results", + "structure", + "folding", + "model", + "case", "protein", - "probe", - "secondary", - "effect", + "autonomously", + "useful", + "embedded", + "folded", + "impossible", + "stability", + "become", + "proteins", + "would", "solution", + "limit", + "stabilization", + "strands", + "several", "essential", - "structure", + "use", + "strand", + "may", + "examined", + "intrinsic", + "seven", + "systems", + "peptides", "relationship", - "nine", - "additional", - "grow", - "establishing", - "preferences", - "folding", + "suggest", "conformations", - "systems", - "structural", - "case", - "intrinsic", - "five", - "stabilization" + "data", + "secondary", + "stable", + "lengthening", + "longer", + "aqueous", + "establishing", + "five" ], "release_date":"2001-09-19", "publication":"\"Length-dependent stability and strand length limits in antiparallel beta -sheet secondary structure\", Proc.Natl.Acad.Sci.USA, 98, 12015-12020", @@ -4806,61 +4807,61 @@ "four-stranded antiparallel beta-sheet" ], "keywords":[ - "exchange", - "thermal", - "data", + "designed", + "conformation", + "antiparallel", + "cm", + "energy", + "water", + "association", "u", - "moderately", + "heteronuclear", + "first", + "core", + "3", + "shifts", "amide", - "undergo", + "dominant", + "approximately", + "transitions", + "specific", + "moderately", + "report", + "barrier", "connected", + "isotope", "reversible", - "chemical", - "slowed", - "patterns", - "low", - "report", - "dominant", "temperature", - "modules", - "cm", - "isotope", - "barrier", - "designed", - "unfolded", - "heteronuclear", + "nonsymmetrical", + "nmr", "f", - "two", - "specific", + "protein", + "thermal", + "folded", + "patterns", + "ph", + "modules", + "low", + "betacore", "periodicity", - "approximately", + "equilibrium", "noes", - "3", - "antiparallel", - "folds", - "folded", - "ii", - "core", + "hydrogen", "significant", - "protein", + "exchange", "numerous", - "conformation", - "cooperative", - "shifts", - "nonsymmetrical", - "nmr", - "betacore", - "association", - "transitions", - "equilibrium", - "water", - "energy", - "ph", + "two", + "conformations", "ensemble", + "data", + "chemical", + "unfolded", "global", - "first", - "conformations", - "hydrogen" + "folds", + "cooperative", + "slowed", + "undergo", + "ii" ], "release_date":"2002-07-10", "publication":"\"BetaCore, a designed water soluble four-stranded antiparallel beta-sheet protein\", Protein Sci., 11, 1539-1551", @@ -4968,61 +4969,61 @@ "beta-hairpin" ], "keywords":[ - "library", - "structured", - "results", - "build", - "deconvolution", - "population", + "templates", "defined", - "combinatorial", - "approach", - "resulted", - "higher", + "shows", + "sequences", + "functionality", + "show", + "identification", + "30", "de", - "stable", - "solutions", - "linear", - "four", + "starting", + "used", + "approaches", + "around", + "selected", "70", + "structured", + "structure", "fold", - "peptide", - "peptides", - "percentage", + "deconvolution", + "solutions", + "results", + "library", + "complexity", + "nmr", + "plain", + "build", + "linear", + "approach", + "positions", + "20", "4", - "used", - "highly", - "approaches", + "reduced", + "resulted", + "showed", "36", + "combinatorial", + "sequence", + "buffered", + "dichroism", + "highly", + "population", + "circular", + "peptides", "two", + "present", "evolve", - "obtain", - "show", + "stable", + "higher", + "four", "introduced", - "sequences", - "reduced", - "functionality", - "30", - "positions", - "present", + "percentage", "using", - "templates", - "nmr", - "complexity", - "structure", - "showed", - "sequence", - "circular", - "buffered", + "peptide", "could", - "20", - "shows", - "dichroism", - "plain", - "around", - "starting", - "selected", - "identification" + "obtain" ], "release_date":"2001-10-17", "publication":"\"Combinatorial approaches: a new tool to search for highly structured beta-hairpin peptides\", Proc.Natl.Acad.Sci.USA, 99, 614-619", @@ -5124,13 +5125,15 @@ "classification_suggested":[ "engineered", "rational", + "rational", "computational", "physics-based", - "computational", "consensus", + "computational", "consensus", "rational", - "consensus", + "computational", + "physics-based", "rational", "computational", "physics-based" @@ -5141,97 +5144,97 @@ ], "subtitle":"X-ray structure of the coiled coil gcn4 acid base heterodimer acid-d12ia16v base-d12la16l", "tags":[ - "coiled coil heterodimer", - "de novo protein" + "de novo protein", + "coiled coil heterodimer" ], "keywords":[ - "superimpose", - "unfolding", + "dimers", + "molecular", + "show", + "methods", + "experimental", + "well", + "predictions", + "three", + "free", "results", - "initially", - "use", - "augments", + "nonhydrogen", + "make", "strategy", + "dual", + "protein", + "six", + "unfolding", + "relax", + "extensive", "test", - "designed", - "geometries", - "stabilities", - "methods", + "procedure", "crystal", - "nonhydrogen", - "show", - "sampling", - "interactions", - "mechanics", - "predict", - "relax", - "average", - "interaction", - "coiled", - "excellent", - "proteins", - "solved", + "initially", + "stabilities", "goal", - "atoms", - "paper", - "published", - "step", + "heterodimeric", + "conformational", "rotamer", - "procedure", - "onto", - "structures", + "minimization", + "superimpose", + "agreement", + "mechanics", + "step", + "selected", + "relative", + "comprises", + "library", + "occur", "derived", - "coils", - "three", - "biology", - "measurements", - "extensive", - "free", - "previously", - "series", - "performance", - "data", - "deviations", - "molecular", - "predictions", + "approach", + "proteins", + "published", + "use", "energies", - "calculations", + "predict", + "coils", + "computational", "1", - "method", - "specificities", + "measurements", + "geometries", + "critical", + "sampling", + "energy", + "onto", "agree", - "agreement", - "six", - "error", - "occur", - "describe", - "sequence", + "biology", + "tested", + "atoms", "good", - "minimization", - "energy", + "also", + "performance", + "interaction", + "series", + "types", + "sequence", + "predicted", + "solved", + "excellent", + "describe", + "range", "rms", + "method", + "designed", + "calculations", + "average", + "specificities", + "structures", + "previously", "important", - "selected", - "range", - "predicted", - "library", - "make", - "tested", - "critical", - "conformational", - "approach", - "also", - "experimental", - "well", - "heterodimeric", - "comprises", - "dimers", - "protein", + "deviations", + "interactions", "homodimers", - "dual", - "types", - "computational", - "relative" + "coiled", + "augments", + "error", + "data", + "paper" ], "release_date":"2001-11-28", "publication":"\"Side-chain repacking calculations for predicting structures and stabilities of heterodimeric coiled coils\", Proc.Natl.Acad.Sci.USA, 98, 14825-14830", @@ -5268,13 +5271,13 @@ ], "struct_thr_sim_designed":[ - { - "sim":0.9986000061, - "partner":"1kd9" - }, { "sim":0.9987000227, "partner":"1kdd" + }, + { + "sim":0.9986000061, + "partner":"1kd9" } ], "struct_thr_sim_natural":[ @@ -5341,10 +5344,15 @@ "classification_suggested":[ "engineered", "rational", + "rational", "computational", "physics-based", + "consensus", "computational", - "consensus" + "consensus", + "rational", + "computational", + "physics-based" ], "classification_suggested_reason":[ "Dek's classification: engineered", @@ -5352,97 +5360,97 @@ ], "subtitle":"X-ray structure of the coiled coil gcn4 acid base heterodimer acid-d12la16l base-d12la16l", "tags":[ - "coiled coil heterodimer", - "de novo protein" + "de novo protein", + "coiled coil heterodimer" ], "keywords":[ - "superimpose", - "unfolding", + "dimers", + "molecular", + "show", + "methods", + "experimental", + "well", + "predictions", + "three", + "free", "results", - "initially", - "use", - "augments", + "nonhydrogen", + "make", "strategy", + "dual", + "protein", + "six", + "unfolding", + "relax", + "extensive", "test", - "designed", - "geometries", - "stabilities", - "methods", + "procedure", "crystal", - "nonhydrogen", - "show", - "sampling", - "interactions", - "mechanics", - "predict", - "relax", - "average", - "interaction", - "coiled", - "excellent", - "proteins", - "solved", + "initially", + "stabilities", "goal", - "atoms", - "paper", - "published", - "step", + "heterodimeric", + "conformational", "rotamer", - "procedure", - "onto", - "structures", + "minimization", + "superimpose", + "agreement", + "mechanics", + "step", + "selected", + "relative", + "comprises", + "library", + "occur", "derived", - "coils", - "three", - "biology", - "measurements", - "extensive", - "free", - "previously", - "series", - "performance", - "data", - "deviations", - "molecular", - "predictions", + "approach", + "proteins", + "published", + "use", "energies", - "calculations", + "predict", + "coils", + "computational", "1", - "method", - "specificities", + "measurements", + "geometries", + "critical", + "sampling", + "energy", + "onto", "agree", - "agreement", - "six", - "error", - "occur", - "describe", - "sequence", + "biology", + "tested", + "atoms", "good", - "minimization", - "energy", + "also", + "performance", + "interaction", + "series", + "types", + "sequence", + "predicted", + "solved", + "excellent", + "describe", + "range", "rms", + "method", + "designed", + "calculations", + "average", + "specificities", + "structures", + "previously", "important", - "selected", - "range", - "predicted", - "library", - "make", - "tested", - "critical", - "conformational", - "approach", - "also", - "experimental", - "well", - "heterodimeric", - "comprises", - "dimers", - "protein", + "deviations", + "interactions", "homodimers", - "dual", - "types", - "computational", - "relative" + "coiled", + "augments", + "error", + "data", + "paper" ], "release_date":"2001-11-28", "publication":"\"Side-chain repacking calculations for predicting structures and stabilities of heterodimeric coiled coils\", Proc.Natl.Acad.Sci.USA, 98, 14825-14830", @@ -5556,16 +5564,6 @@ "classification_suggested":[ "engineered", "rational", - "computational", - "physics-based", - "computational", - "consensus", - "consensus", - "rational", - "consensus", - "rational", - "computational", - "physics-based", "rational", "computational", "physics-based" @@ -5576,97 +5574,97 @@ ], "subtitle":"X-ray structure of the coiled coil gcn4 acid base heterodimer acid-d12la16i base-d12la16l", "tags":[ - "coiled coil heterodimer", - "de novo protein" + "de novo protein", + "coiled coil heterodimer" ], "keywords":[ - "superimpose", - "unfolding", + "dimers", + "molecular", + "show", + "methods", + "experimental", + "well", + "predictions", + "three", + "free", "results", - "initially", - "use", - "augments", + "nonhydrogen", + "make", "strategy", + "dual", + "protein", + "six", + "unfolding", + "relax", + "extensive", "test", - "designed", - "geometries", - "stabilities", - "methods", + "procedure", "crystal", - "nonhydrogen", - "show", - "sampling", - "interactions", - "mechanics", - "predict", - "relax", - "average", - "interaction", - "coiled", - "excellent", - "proteins", - "solved", + "initially", + "stabilities", "goal", - "atoms", - "paper", - "published", - "step", + "heterodimeric", + "conformational", "rotamer", - "procedure", - "onto", - "structures", + "minimization", + "superimpose", + "agreement", + "mechanics", + "step", + "selected", + "relative", + "comprises", + "library", + "occur", "derived", - "coils", - "three", - "biology", - "measurements", - "extensive", - "free", - "previously", - "series", - "performance", - "data", - "deviations", - "molecular", - "predictions", + "approach", + "proteins", + "published", + "use", "energies", - "calculations", + "predict", + "coils", + "computational", "1", - "method", - "specificities", + "measurements", + "geometries", + "critical", + "sampling", + "energy", + "onto", "agree", - "agreement", - "six", - "error", - "occur", - "describe", - "sequence", + "biology", + "tested", + "atoms", "good", - "minimization", - "energy", + "also", + "performance", + "interaction", + "series", + "types", + "sequence", + "predicted", + "solved", + "excellent", + "describe", + "range", "rms", + "method", + "designed", + "calculations", + "average", + "specificities", + "structures", + "previously", "important", - "selected", - "range", - "predicted", - "library", - "make", - "tested", - "critical", - "conformational", - "approach", - "also", - "experimental", - "well", - "heterodimeric", - "comprises", - "dimers", - "protein", + "deviations", + "interactions", "homodimers", - "dual", - "types", - "computational", - "relative" + "coiled", + "augments", + "error", + "data", + "paper" ], "release_date":"2001-11-28", "publication":"\"Side-chain repacking calculations for predicting structures and stabilities of heterodimeric coiled coils\", Proc.Natl.Acad.Sci.USA, 98, 14825-14830", @@ -5774,75 +5772,75 @@ "subtitle":"Crystal structure of a de novo designed trimeric coiled-coil peptide stablized by ionic interactions", "tags":[ "trimer", - "de novo protein", "coiled coil", + "de novo design", "alpha-helix", - "de novo design" + "de novo protein" ], "keywords":[ - "analytical", - "stability", + "designed", + "complex", + "improve", "verified", + "mainly", + "design", + "characterized", + "hydrophobic", + "repeat", + "spectroscopy", + "show", + "principles", + "de", + "rational", + "possible", + "furthermore", + "different", "combining", - "coiled", - "parent", - "100", - "improve", - "network", "newly", - "solved", - "conditions", - "comparing", - "common", - "de", - "oligomerization", - "novo", - "stable", + "properties", + "structure", "intrahelical", - "rational", - "four", - "characterized", - "along", - "analyzed", - "peptide", - "peptides", - "designed", - "ultracentrifugation", + "addition", "cd", - "spectroscopy", - "mainly", - "interface", - "different", - "highly", - "physiological", - "dimeric", - "two", - "motif", + "recently", + "interactions", + "protein", + "network", + "oligomerization", + "stability", "improved", + "motif", + "conditions", + "coiled", "ionic", - "occurring", - "arrangements", - "furthermore", - "addition", + "novo", + "analytical", "domains", - "show", - "design", - "protein", - "interactions", - "hydrophobic", - "complex", - "coils", - "structure", - "stabilized", - "contribution", - "repeat", - "extend", "types", - "recently", + "highly", + "interface", + "solved", + "common", + "extend", + "peptides", "favorable", - "principles", - "possible", - "properties" + "physiological", + "two", + "along", + "parent", + "contribution", + "coils", + "stable", + "four", + "comparing", + "arrangements", + "analyzed", + "100", + "ultracentrifugation", + "stabilized", + "peptide", + "occurring", + "dimeric" ], "release_date":"2002-08-07", "publication":"\"Improving coiled-coil stability by optimizing ionic interactions\", J.Mol.Biol., 318, 901-910", @@ -5937,65 +5935,65 @@ ], "subtitle":"Nmr structure of trp-cage miniprotein construct tc5b", "tags":[ - "miniprotein", "de novo protein", + "trp-cage", "two-state folding", - "trp-cage" + "miniprotein" ], "keywords":[ - "reported", - "unfolding", + "cooperative", + "simulations", + "effective", + "design", "poorly", - "pro", + "miniproteins", "chain", "constructs", - "studies", - "testing", - "date", - "stable", - "strategy", - "driven", "experimental", - "rings", - "peptide", - "fold", - "smallest", - "peptides", - "95", - "may", "sheath", - "miniprotein", - "physiological", - "provide", - "simulations", - "mutation", - "motif", - "pathways", + "trp", + "95", + "testing", + "encapsulation", + "side", "particularly", + "priori", + "truncation", + "fold", + "pro", + "provide", + "folding", + "driven", + "strategy", + "interactions", + "protein", "folded", - "ground", - "design", + "ph", + "significantly", + "unfolding", + "motif", "produced", - "effective", - "protein", - "cooperative", - "interactions", - "priori", + "may", + "date", + "reported", "hydrophobically", - "construct", - "water", - "optimize", - "encapsulation", + "ground", + "peptides", + "physiological", + "rings", + "studies", + "stable", + "miniprotein", "designated", - "truncation", - "significantly", + "construct", + "pathways", + "mutation", "computational", - "ph", - "trp", - "side", + "peptide", + "optimize", "novel", - "folding", - "miniproteins" + "smallest", + "water" ], "release_date":"2002-05-29", "publication":"\"Designing a 20-residue protein\", Nat.Struct.Biol., 9, 425-430", @@ -6088,89 +6086,90 @@ ], "classification":"unknown", "classification_suggested":[ - "minimal" + "minimal", + "rational" ], "classification_suggested_reason":[ "Dek's classification: small, non-systematic, and other" ], "subtitle":"Octameric de novo designed peptide", "tags":[ + "coiled coil", "ionic interactions", - "protein folding", - "protein oligomerization", "de novo protein", - "coiled coil", - "protein de novo design" + "protein folding", + "protein de novo design", + "protein oligomerization" ], "keywords":[ - "series", - "stability", - "analytical", - "salt", - "glu", - "coiled", + "designed", + "form", + "complex", + "central", + "mainly", + "design", + "optimized", + "octameric", "removing", + "hydrophobic", + "repeat", "interhelical", - "longer", - "seam", - "network", - "long", - "optimized", - "common", - "extended", + "spectroscopy", + "show", + "able", + "rather", "de", + "represent", + "devoid", + "arg", + "effect", + "assembly", + "bridges", + "residues", + "important", + "intrahelical", + "extended", + "structure", + "replacing", + "alanine", + "cd", + "recently", + "crystallography", + "interactions", + "seam", + "protein", "oligomerization", - "novo", + "network", "globular", - "intrahelical", + "stability", + "salt", + "helical", + "glu", + "motif", + "interaction", + "formation", + "coiled", + "series", + "ionic", + "novo", + "analytical", + "parallel", + "highly", + "interface", "missing", - "analyzed", - "along", - "bridges", - "crystallography", - "octameric", - "peptide", + "common", "peptides", - "designed", - "ultracentrifugation", - "cd", - "spectroscopy", - "mainly", - "interface", - "residues", - "highly", "two", - "motif", - "parallel", - "ionic", - "occurring", - "central", - "replacing", - "show", - "design", - "helical", - "assumes", - "protein", - "interactions", - "rather", - "hydrophobic", - "complex", - "effect", - "devoid", + "along", "coils", - "represent", - "structure", + "assumes", + "longer", + "long", + "analyzed", + "ultracentrifugation", "stabilized", - "assembly", - "repeat", - "recently", - "able", - "formation", - "form", - "alanine", - "important", - "arg", - "interaction" + "peptide", + "occurring" ], "release_date":"2002-11-13", "publication":"\"Removing an interhelical salt bridge abolishes coiled-coil formation in a de novo designed peptide\", J.STRUCT.BIOL., 137, 65-72", @@ -6270,70 +6269,70 @@ "subtitle":"Nmr structure of tryptophan zipper 1: a stable, monomeric beta-hairpin with a type ii' turn", "tags":[ "de novo protein", - "beta-hairpin", - "type ii' turn" + "type ii' turn", + "beta-hairpin" ], "keywords":[ + "reveal", + "designed", + "tertiary", + "12", + "conformation", + "adopt", + "sequences", + "cooperatively", + "however", + "metal", + "structural", + "length", + "observed", + "even", + "structures", + "requiring", + "previously", + "different", + "hairpin", + "free", + "16", + "three", + "exceptionally", "without", - "reported", "monomeric", - "amino", - "proteins", - "larger", - "greatly", - "unique", + "fold", + "stabilizes", + "short", + "folding", + "nmr", + "disulfide", + "amino", + "crosslinks", + "proteins", + "binding", "trpzip", - "length", + "motif", + "greatly", + "aa", + "indole", "energies", - "four", - "metal", - "rings", - "fold", + "reported", + "tryptophan", "substantially", - "smallest", "peptides", - "designed", + "larger", + "turn", "acids", - "different", - "tryptophan", - "reveal", - "short", - "trpzips", - "motif", - "aa", - "requiring", - "crosslinks", - "stabilizes", - "12", - "observed", - "sequences", - "structures", - "conformation", - "exceptionally", - "adopt", - "exceed", - "nmr", - "pairs", - "water", - "three", "zipper", - "stabilized", - "tertiary", - "unusual", - "16", - "hairpin", - "turn", - "cooperatively", - "however", - "disulfide", - "folding", - "free", "conformations", - "binding", - "structural", - "indole", - "even", - "previously" + "rings", + "exceed", + "unique", + "four", + "unusual", + "stabilized", + "pairs", + "trpzips", + "smallest", + "water" ], "release_date":"2002-04-24", "publication":"\"Tryptophan zippers: stable, monomeric beta -hairpins\", Proc.Natl.Acad.Sci.USA, 98, 5578-5583", @@ -6424,78 +6423,79 @@ ], "classification":"unknown", "classification_suggested":[ - "minimal" + "minimal", + "rational" ], "classification_suggested_reason":[ "Dek's classification: small, non-systematic, and other" ], "subtitle":"Nmr structure of tryptophan zipper 2: a stable, monomeric beta-hairpin with a type i' turn", "tags":[ - "type i' turn", "de novo protein", - "beta-hairpin" + "beta-hairpin", + "type i' turn" ], "keywords":[ + "reveal", + "designed", + "tertiary", + "12", + "conformation", + "adopt", + "sequences", + "cooperatively", + "however", + "metal", + "structural", + "length", + "observed", + "even", + "structures", + "requiring", + "previously", + "different", + "hairpin", + "free", + "16", + "three", + "exceptionally", "without", - "reported", "monomeric", + "fold", + "stabilizes", + "short", + "folding", + "nmr", + "disulfide", "amino", + "crosslinks", "proteins", - "larger", - "greatly", - "unique", + "binding", "trpzip", - "length", + "motif", + "greatly", + "aa", + "indole", "energies", - "four", - "metal", - "rings", - "fold", + "reported", + "tryptophan", "substantially", - "smallest", "peptides", - "designed", + "larger", + "turn", "acids", - "different", - "tryptophan", - "reveal", - "short", - "trpzips", - "motif", - "aa", - "requiring", - "crosslinks", - "stabilizes", - "12", - "observed", - "sequences", - "structures", - "conformation", - "exceptionally", - "adopt", - "exceed", - "nmr", - "pairs", - "water", - "three", "zipper", - "stabilized", - "tertiary", - "unusual", - "16", - "hairpin", - "turn", - "cooperatively", - "however", - "disulfide", - "folding", - "free", "conformations", - "binding", - "structural", - "indole", - "even", - "previously" + "rings", + "exceed", + "unique", + "four", + "unusual", + "stabilized", + "pairs", + "trpzips", + "smallest", + "water" ], "release_date":"2002-04-24", "publication":"\"Tryptophan zippers: stable, monomeric beta -hairpins\", Proc.Natl.Acad.Sci.USA, 98, 5578-5583", @@ -6586,78 +6586,79 @@ ], "classification":"unknown", "classification_suggested":[ - "minimal" + "minimal", + "rational" ], "classification_suggested_reason":[ "Dek's classification: small, non-systematic, and other" ], "subtitle":"Nmr structure of tryptophan zipper 4: a stable beta-hairpin peptide based on the c-terminal hairpin of the b1 domain of protein g", "tags":[ - "type i beta-turn", "protein binding", - "beta-hairpin" + "beta-hairpin", + "type i beta-turn" ], "keywords":[ + "reveal", + "designed", + "tertiary", + "12", + "conformation", + "adopt", + "sequences", + "cooperatively", + "however", + "metal", + "structural", + "length", + "observed", + "even", + "structures", + "requiring", + "previously", + "different", + "hairpin", + "free", + "16", + "three", + "exceptionally", "without", - "reported", "monomeric", + "fold", + "stabilizes", + "short", + "folding", + "nmr", + "disulfide", "amino", + "crosslinks", "proteins", - "larger", - "greatly", - "unique", + "binding", "trpzip", - "length", + "motif", + "greatly", + "aa", + "indole", "energies", - "four", - "metal", - "rings", - "fold", + "reported", + "tryptophan", "substantially", - "smallest", "peptides", - "designed", + "larger", + "turn", "acids", - "different", - "tryptophan", - "reveal", - "short", - "trpzips", - "motif", - "aa", - "requiring", - "crosslinks", - "stabilizes", - "12", - "observed", - "sequences", - "structures", - "conformation", - "exceptionally", - "adopt", - "exceed", - "nmr", - "pairs", - "water", - "three", "zipper", - "stabilized", - "tertiary", - "unusual", - "16", - "hairpin", - "turn", - "cooperatively", - "however", - "disulfide", - "folding", - "free", "conformations", - "binding", - "structural", - "indole", - "even", - "previously" + "rings", + "exceed", + "unique", + "four", + "unusual", + "stabilized", + "pairs", + "trpzips", + "smallest", + "water" ], "release_date":"2002-04-24", "publication":"\"Tryptophan zippers: stable, monomeric beta -hairpins\", Proc.Natl.Acad.Sci.USA, 98, 5578-5583", @@ -6770,74 +6771,74 @@ "de novo protein" ], "keywords":[ - "notion", - "toward", + "chemistry", + "redox", "analysis", - "powerful", + "calculations", + "controlled", + "design", + "reduction", + "issues", + "structural", + "maintenance", + "mechanistic", + "interesting", "lysine", - "sole", + "methods", "chain", - "density", - "chains", - "characteristics", - "chemistry", - "functional", - "amino", - "involving", - "use", - "report", + "provides", + "used", "de", - "novo", - "detailed", - "catalytic", - "tryptophanyl", - "hybrid", - "calculations", - "manner", + "creation", "feature", - "acids", - "maquette", - "controlled", - "tryptophan", - "used", - "redox", - "interesting", - "cofactors", - "multidimensional", + "functional", + "therefore", + "characteristics", "examine", - "methods", - "system", - "support", - "w", + "involving", + "side", + "detailed", "potential", "helps", - "provides", - "bundle", - "design", + "raises", "apparent", "explain", - "mechanistic", - "basis", - "significant", - "creation", - "protein", - "model", - "reduction", + "structure", + "multidimensional", + "w", + "report", + "cofactors", + "tryptophanyl", + "powerful", "degrees", + "model", "nmr", - "therefore", - "structure", - "issues", - "activated", + "protein", + "basis", + "amino", + "exploring", + "interaction", "radical", - "mediated", - "side", - "maintenance", - "structural", "pair", - "raises", - "exploring", - "interaction" + "use", + "notion", + "mediated", + "manner", + "novo", + "support", + "system", + "tryptophan", + "acids", + "catalytic", + "activated", + "density", + "toward", + "maquette", + "sole", + "hybrid", + "chains", + "bundle", + "significant" ], "release_date":"2002-06-05", "publication":"\"Structure of a De Novo Designed Protein Model of Radical Enzymes\", J.Am.Chem.Soc., 124, 10952-10953", @@ -6944,10 +6945,10 @@ ], "subtitle":"Sliding helix induced change of coordination geometry in a model di-mn(ii) protein", "tags":[ - "alpha-helical bundle", "de novo protein", - "sliding helix", - "protein design" + "alpha-helical bundle", + "protein design", + "sliding helix" ], "keywords":[ "description", @@ -6989,24 +6990,24 @@ ], "struct_thr_sim_designed":[ { - "sim":0.9822000265, - "partner":"1jm0" + "sim":0.9875000119, + "partner":"1ovu" }, { - "sim":0.9667000175, - "partner":"1ec5" + "sim":0.9822000265, + "partner":"1jm0" }, { "sim":0.9577999711, "partner":"1jmb" }, { - "sim":0.9991000295, - "partner":"1ovr" + "sim":0.9667000175, + "partner":"1ec5" }, { - "sim":0.9875000119, - "partner":"1ovu" + "sim":0.9991000295, + "partner":"1ovr" } ], "struct_thr_sim_natural":[ @@ -7075,128 +7076,128 @@ ], "subtitle":"Crystal structure of a molecular maquette scaffold", "tags":[ - "four-helix bundle", + "de novo protein", + "heme binding protein", "maquette", "electron transport", - "heme binding protein", - "de novo protein", + "four-helix bundle", "heme binding" ], "keywords":[ - "maquettes", - "follows", - "mad", - "heptad", - "pattern", - "scaffolds", - "peptide", - "test", - "heeflkk", - "designed", - "generated", - "interact", - "parallel", - "mobile", - "partly", - "typical", - "structure", - "repeat", - "molten", + "repeats", + "engineering", "redesign", - "designers", - "oxidoreductases", - "interfaces", + "hydrophobic", + "resolution", + "repeat", + "pattern", + "13", + "points", + "deviation", "hpphhpp", - "structured", + "phasing", + "heme", + "residue", + "heerlkkm", + "degrees", + "31", + "protein", "partially", - "topology", - "solved", - "feellkl", - "similar", + "globular", + "positions", + "binding", + "novo", + "subsequent", + "test", + "expected", "crossing", - "de", - "h", - "minimalist", - "6", - "criteria", - "distribution", - "used", + "hpphhph", + "helices", + "using", + "similar", + "construction", "initial", - "nature", - "differently", - "alternating", - "positions", - "likely", - "size", - "shows", - "phasing", - "properties", - "unexpected", "taken", - "expected", - "31", - "subsequent", + "shows", + "p", + "molten", + "distribution", + "due", "eiwkl", - "generate", - "report", - "globular", - "resolution", - "call", - "four", - "maquette", + "residues", + "angles", + "polar", + "cggg", + "l31m", + "oxidoreductases", + "approach", + "interact", + "criteria", + "packing", + "size", + "several", + "2", "may", - "engineering", + "scaffold", + "found", + "maquette", + "four", + "iterative", "bundle", - "several", - "points", + "peptide", + "set", + "heptad", + "pocket", "mimicries", - "type", - "iterative", "design", - "heerlkkm", - "rather", - "using", - "hydrophobic", - "nmr", - "sequence", - "repeats", - "packing", - "13", - "variant", - "l31m", - "designs", - "one", - "construction", - "helices", - "approach", - "novo", - "heme", - "sufficient", + "follows", + "topology", "spectroscopy", - "deviation", - "residues", - "found", - "f", - "due", - "set", - "scaffold", - "polar", "exists", - "hpphhph", - "criterion", - "protein", - "residue", - "2", - "degrees", + "used", + "partly", + "resolved", + "properties", + "variant", + "mobile", + "f", + "type", + "alternating", + "designers", + "parallel", + "sequence", + "solved", + "identical", "refined", + "designed", + "h", + "criterion", "translations", - "identical", - "cggg", - "angles", - "pocket", - "p", - "binding", - "resolved" + "feellkl", + "one", + "interfaces", + "6", + "differently", + "rather", + "mad", + "de", + "call", + "structured", + "likely", + "structure", + "scaffolds", + "report", + "nmr", + "typical", + "nature", + "heeflkk", + "minimalist", + "generated", + "sufficient", + "maquettes", + "unexpected", + "designs", + "generate" ], "release_date":"2003-02-18", "publication":"\"X-ray Structure of a Maquette Scaffold\", J.Mol.Biol., 326, 1219-1225", @@ -7302,60 +7303,60 @@ ], "subtitle":"Crystal structure of a designed zinc finger protein bound to dna", "tags":[ - "transferase\/dna", - "zinc finger", "transferase-dna complex", - "protein design", "complex (zinc finger-dna)", - "protein-dna interaction" + "protein-dna interaction", + "transferase\/dna", + "protein design", + "zinc finger" ], "keywords":[ - "considerable", - "finger", - "proteins", - "studied", - "reveals", - "dna", - "report", - "contact", - "selection", - "examined", "designed", - "modular", - "zinc", - "tandem", - "simple", + "relatively", + "complex", "adaptations", - "experimentally", - "crystal", - "cys2his2", + "extensively", + "design", "oligonucleotide", - "site", + "structural", + "selection", "effort", - "devoted", + "simple", + "experimentally", + "differences", + "dna", "based", - "design", - "domains", - "basis", - "lengths", + "finger", + "three", + "properties", + "structure", + "studied", + "report", + "residue", + "favourable", "protein", - "arrays", "interactions", - "residue", - "complex", + "lengths", + "basis", + "proteins", + "cys2his2", + "binding", + "devoted", + "considerable", + "tandem", + "arrays", + "site", + "domains", + "modular", + "examined", + "comprised", + "reveals", + "contact", "recent", - "structure", - "extensively", - "three", + "crystal", "corresponding", - "favourable", - "relatively", - "differences", - "comprised", - "binding", - "structural", - "properties", - "compensate" + "compensate", + "zinc" ], "release_date":"1997-03-12", "publication":"\"A 2.2 A Resolution Crystal Structure of a Designed Zinc Finger Protein Bound to DNA\", Nat.Struct.Biol., 3, 940-945", @@ -7464,113 +7465,113 @@ ], "subtitle":"Sank e3_5: an artificial ankyrin repeat protein", "tags":[ + "de novo protein", "ankyrin repeat", "consensus", - "de novo protein", "protein engineering" ], "keywords":[ - "domain", - "standardized", - "many", - "represents", - "providing", - "use", - "chosen", - "expressed", - "designed", - "generated", - "randomly", - "noteworthy", - "crystal", - "determined", - "features", - "based", + "defined", + "escherichia", + "hydrophobic", + "structural", + "resolution", + "repeat", "show", - "basis", - "regions", - "interactions", - "suggested", + "intrinsically", + "randomized", + "randomly", + "extended", + "framework", + "numbers", + "insight", + "protein", "members", - "irregularities", - "ar", - "structure", - "display", - "repeat", - "escherichia", + "binding", + "mediate", + "cellular", + "thermodynamic", "networks", - "turn", + "rigorous", + "innumerable", + "crystal", + "region", + "total", + "stable", + "conclude", + "interacting", + "cytoplasm", + "glycines", "able", - "novel", - "constituting", - "fashion", - "interfaces", - "excellent", + "soluble", + "fixed", + "represents", + "furthermore", + "residues", + "finding", + "library", + "noteworthy", + "occur", + "basis", + "stability", "proteins", + "several", + "use", + "consensus", + "ankyrin", + "ramachandran", "combinatorial", + "hydrogen", "highly", - "furthermore", + "scaffold", + "found", + "bond", + "features", + "complementary", + "regions", + "design", + "constituting", "30", "natural", - "cellular", - "numbers", - "form", - "molecules", - "hydrogen", - "intrinsically", - "consensus", - "stability", - "framework", - "plot", - "randomized", - "defined", + "virtually", + "absence", + "display", + "domain", + "consisting", + "fold", + "also", + "chosen", + "irregularities", + "standardized", "coli", - "extended", - "glycines", - "resolution", - "fixed", - "thermodynamic", - "finding", - "interacting", - "region", - "innumerable", - "several", - "design", - "soluble", - "bond", - "occur", - "hydrophobic", - "high", "sequence", - "mediate", + "suggested", + "excellent", + "analyses", + "plot", + "designed", + "form", "phyla", - "virtually", - "total", - "structural", - "library", - "conclude", - "consisting", - "rigorous", + "many", "one", - "analyses", - "also", - "stable", - "cytoplasm", - "fold", - "insight", + "interfaces", + "loop", + "providing", + "expressed", + "based", "besides", - "ankyrin", - "residues", - "found", - "absence", - "complementary", - "scaffold", - "ramachandran", - "protein", + "ar", + "structure", + "determined", + "interactions", + "molecules", "regular", - "binding", - "loop", - "libraries" + "fashion", + "high", + "generated", + "turn", + "libraries", + "novel" ], "release_date":"2003-01-21", "publication":"\"Designed to be stable: Crystal structure of a consensus ankyrin repeat protein\", Proc.Natl.Acad.Sci.USA, 100, 1700-1705", @@ -7806,148 +7807,147 @@ ], "classification":"unknown", "classification_suggested":[ - "minimal", - "rational" + "minimal" ], "classification_suggested_reason":[ "Dek's classification: small, non-systematic, and other" ], "subtitle":"A minimal beta-hairpin peptide scaffold for beta-turn display", "tags":[ + "beta hairpin", "de novo protein", "beta turn", - "beta hairpin", "cyclic disulfide" ], "keywords":[ - "cx", - "analysis", - "decreases", - "predictive", - "studies", - "contributions", - "stabilizing", + "correlated", + "finally", + "individual", + "hairpins", + "adopt", + "opposite", + "structural", "observe", "pattern", - "acid", - "explained", - "peptide", - "prediction", + "differs", + "side", + "differences", "substitutions", - "find", - "instead", - "position", - "interactions", - "8", + "free", + "explain", + "acid", + "residue", + "folding", + "model", + "protein", + "successfully", + "linear", + "positions", + "helical", + "changes", + "stabilization", + "measured", + "novo", + "general", + "predictive", + "substitution", + "twisted", + "either", "conformation", - "adopt", - "typical", - "designing", - "structure", - "c", - "diversity", - "favorable", - "conformations", + "characterized", + "stabilizing", + "examine", + "faces", + "selected", + "effect", + "relative", + "accessible", + "residues", "cyclic", "considering", - "general", - "coiled", - "allows", - "chain", - "unique", - "immediately", - "de", - "propensities", - "linear", - "characterized", - "finally", - "twisted", - "successfully", - "small", - "used", - "highly", - "suggests", - "difficult", - "often", + "useful", "folded", - "measured", - "concept", - "individual", - "structures", - "positions", - "particular", - "appropriate", - "either", - "free", - "solvent", - "previously", "stability", - "twist", - "unexpected", - "multistranded", - "substitution", - "amino", - "strand", + "sites", "large", - "trpzip", - "host", - "changes", - "accessibility", - "surprisingly", + "valine", "may", - "useful", - "examine", - "faces", - "choose", + "twist", + "explained", + "scaffold", + "highly", + "small", + "importance", + "peptide", + "surprisingly", + "c", + "preceding", + "designing", + "localized", "design", - "model", - "helical", - "cooperative", - "present", - "effect", - "nmr", - "differs", - "association", - "measurement", - "indicate", + "decreases", "energy", - "correlated", - "decrease", - "opposite", - "structural", - "selected", - "stabilization", - "sites", - "localized", - "importance", + "beta", + "chain", + "used", + "instead", + "suggests", + "choose", + "apply", "cysteine", - "valine", - "accessible", + "diversity", + "appropriate", "also", - "novo", + "prediction", + "isoleucine", "driven", + "amino", + "trpzip", + "propensities", + "immediately", + "allows", + "backbone", + "multistranded", "peptides", - "apply", + "developed", + "cx", + "present", + "unique", + "contributions", + "measurement", + "cooperative", + "analysis", + "particular", + "often", + "indicate", + "association", + "structures", + "de", + "emphasizes", + "previously", + "hairpin", + "concept", + "structure", + "accessibility", + "host", + "nmr", + "interactions", + "typical", + "find", + "coiled", + "strand", "proven", - "residues", - "scaffold", - "explain", - "preceding", - "protein", - "residue", - "isoleucine", - "backbone", - "differences", + "difficult", + "favorable", + "conformations", + "solvent", + "studies", + "position", + "unexpected", + "libraries", "contribution", - "hairpins", - "hairpin", - "beta", - "side", - "emphasizes", - "folding", - "relative", - "developed", - "libraries" + "decrease", + "8" ], "release_date":"2003-02-04", "publication":"\"Stability of cyclic beta-hairpins: asymmetric contributions from side chains of a hydrogen-bonded cross-strand residue pair\", J.Am.Chem.Soc., 125, 388-395", @@ -8046,104 +8046,104 @@ ], "subtitle":"Turn stability in beta-hairpin peptides: 3:5 type i g1 bulge turns", "tags":[ - "beta-turn", - "de novo protein", "beta hairpin", + "de novo protein", + "beta-turn", "beta-bulge" ], "keywords":[ - "least", - "analysis", - "cases", - "remained", - "predictive", - "contributions", - "use", - "reverse", - "g1", + "individual", + "hairpins", + "experimental", + "retains", "acid", - "scaffolds", - "peptide", - "test", - "stabilities", - "bulge", - "sequences", - "energetic", - "equilibrium", - "structure", - "turns", - "turn", - "leads", - "limiting", - "however", - "starting", - "molecule", - "power", - "generating", + "parameters", + "adopted", + "protein", "substituting", - "suggesting", - "investigated", - "indicated", - "propensities", - "judged", "linear", - "less", - "dependence", - "ability", - "folded", - "individual", - "solution", - "projects", + "indicated", + "equilibrium", + "test", + "predictive", + "power", + "two", + "substitution", + "stable", "effects", - "measurements", "indicates", - "series", - "bhpw", - "stability", - "loops", - "substitution", - "amino", + "stabilities", + "antiparallel", + "however", + "starting", + "mimicry", + "selected", + "relative", + "residues", "connected", "contained", - "moreover", + "folded", + "bulge", "useful", - "pdg", - "type", + "stability", + "capable", + "turns", + "use", + "scaffold", + "suggesting", + "peptide", + "set", + "measurements", + "molecule", + "g1", "design", "context", - "nmr", - "sequence", - "exploited", - "parameters", - "formation", - "adopted", - "retains", - "selected", + "moreover", "diverse", - "strands", - "substituted", - "population", + "energetic", + "loops", + "leads", "also", - "mimicry", + "least", + "amino", + "type", + "solution", + "formation", + "propensities", "evaluate", - "stable", - "way", - "experimental", + "reverse", + "series", + "ability", + "sequence", + "population", "peptides", - "residues", - "capable", - "displaying", - "two", + "substituted", + "generating", + "judged", + "contributions", + "dependence", "folds", - "antiparallel", "central", - "scaffold", - "set", - "significant", - "protein", - "hairpins", - "relative", - "libraries" + "analysis", + "displaying", + "sequences", + "investigated", + "way", + "limiting", + "pdg", + "bhpw", + "structure", + "scaffolds", + "nmr", + "cases", + "projects", + "remained", + "strands", + "turn", + "libraries", + "exploited", + "less", + "significant" ], "release_date":"2003-10-21", "publication":"\"Turn stability in beta-hairpin peptides: Investigation of peptides containing 3:5 type I G1 bulge turns\", PROTEIN SCI., 12, 237-247", @@ -8235,147 +8235,148 @@ ], "classification":"unknown", "classification_suggested":[ - "minimal" + "minimal", + "rational" ], "classification_suggested_reason":[ "Dek's classification: small, non-systematic, and other" ], "subtitle":"Stability of cyclic beta-hairpins: asymmetric contibutions from side chains of hydrogen bonded cross-strand residue pair", "tags":[ + "beta hairpin", "de novo protein", "beta turn", - "beta hairpin", "cyclic disulfide" ], "keywords":[ - "cx", - "analysis", - "decreases", - "predictive", - "studies", - "contributions", - "stabilizing", + "correlated", + "finally", + "individual", + "hairpins", + "adopt", + "opposite", + "structural", "observe", "pattern", - "acid", - "explained", - "peptide", - "prediction", + "differs", + "side", + "differences", "substitutions", - "find", - "instead", - "position", - "interactions", - "8", + "free", + "explain", + "acid", + "residue", + "folding", + "model", + "protein", + "successfully", + "linear", + "positions", + "helical", + "changes", + "stabilization", + "measured", + "novo", + "general", + "predictive", + "substitution", + "twisted", + "either", "conformation", - "adopt", - "typical", - "designing", - "structure", - "c", - "diversity", - "favorable", - "conformations", + "characterized", + "stabilizing", + "examine", + "faces", + "selected", + "effect", + "relative", + "accessible", + "residues", "cyclic", "considering", - "general", - "coiled", - "allows", - "chain", - "unique", - "immediately", - "de", - "propensities", - "linear", - "characterized", - "finally", - "twisted", - "successfully", - "small", - "used", - "highly", - "suggests", - "difficult", - "often", + "useful", "folded", - "measured", - "concept", - "individual", - "structures", - "positions", - "particular", - "appropriate", - "either", - "free", - "solvent", - "previously", "stability", - "twist", - "unexpected", - "multistranded", - "substitution", - "amino", - "strand", + "sites", "large", - "trpzip", - "host", - "changes", - "accessibility", - "surprisingly", + "valine", "may", - "useful", - "examine", - "faces", - "choose", + "twist", + "explained", + "scaffold", + "highly", + "small", + "importance", + "peptide", + "surprisingly", + "c", + "preceding", + "designing", + "localized", "design", - "model", - "helical", - "cooperative", - "present", - "effect", - "nmr", - "differs", - "association", - "measurement", - "indicate", + "decreases", "energy", - "correlated", - "decrease", - "opposite", - "structural", - "selected", - "stabilization", - "sites", - "localized", - "importance", + "beta", + "chain", + "used", + "instead", + "suggests", + "choose", + "apply", "cysteine", - "valine", - "accessible", + "diversity", + "appropriate", "also", - "novo", + "prediction", + "isoleucine", "driven", + "amino", + "trpzip", + "propensities", + "immediately", + "allows", + "backbone", + "multistranded", "peptides", - "apply", + "developed", + "cx", + "present", + "unique", + "contributions", + "measurement", + "cooperative", + "analysis", + "particular", + "often", + "indicate", + "association", + "structures", + "de", + "emphasizes", + "previously", + "hairpin", + "concept", + "structure", + "accessibility", + "host", + "nmr", + "interactions", + "typical", + "find", + "coiled", + "strand", "proven", - "residues", - "scaffold", - "explain", - "preceding", - "protein", - "residue", - "isoleucine", - "backbone", - "differences", + "difficult", + "favorable", + "conformations", + "solvent", + "studies", + "position", + "unexpected", + "libraries", "contribution", - "hairpins", - "hairpin", - "beta", - "side", - "emphasizes", - "folding", - "relative", - "developed", - "libraries" + "decrease", + "8" ], "release_date":"2003-10-21", "publication":"\"Stability of cyclic beta-hairpins: asymmetric contributions from side chains of a hydrogen-bonded cross-strand residue pair\", J.AM.CHEM.SOC., 125, 388-395", @@ -8478,140 +8479,140 @@ ], "subtitle":"Stability of cyclic beta-hairpins: asymmetric contibutions from side chains of hydrogen bonded cross-strand residue pair", "tags":[ + "beta hairpin", "de novo protein", "beta turn", - "beta hairpin", "cyclic disulfide" ], "keywords":[ - "cx", - "analysis", - "decreases", - "predictive", - "studies", - "contributions", - "stabilizing", + "correlated", + "finally", + "individual", + "hairpins", + "adopt", + "opposite", + "structural", "observe", "pattern", - "acid", - "explained", - "peptide", - "prediction", + "differs", + "side", + "differences", "substitutions", - "find", - "instead", - "position", - "interactions", - "8", + "free", + "explain", + "acid", + "residue", + "folding", + "model", + "protein", + "successfully", + "linear", + "positions", + "helical", + "changes", + "stabilization", + "measured", + "novo", + "general", + "predictive", + "substitution", + "twisted", + "either", "conformation", - "adopt", - "typical", - "designing", - "structure", - "c", - "diversity", - "favorable", - "conformations", + "characterized", + "stabilizing", + "examine", + "faces", + "selected", + "effect", + "relative", + "accessible", + "residues", "cyclic", "considering", - "general", - "coiled", - "allows", - "chain", - "unique", - "immediately", - "de", - "propensities", - "linear", - "characterized", - "finally", - "twisted", - "successfully", - "small", - "used", - "highly", - "suggests", - "difficult", - "often", + "useful", "folded", - "measured", - "concept", - "individual", - "structures", - "positions", - "particular", - "appropriate", - "either", - "free", - "solvent", - "previously", "stability", - "twist", - "unexpected", - "multistranded", - "substitution", - "amino", - "strand", + "sites", "large", - "trpzip", - "host", - "changes", - "accessibility", - "surprisingly", + "valine", "may", - "useful", - "examine", - "faces", - "choose", + "twist", + "explained", + "scaffold", + "highly", + "small", + "importance", + "peptide", + "surprisingly", + "c", + "preceding", + "designing", + "localized", "design", - "model", - "helical", - "cooperative", - "present", - "effect", - "nmr", - "differs", - "association", - "measurement", - "indicate", + "decreases", "energy", - "correlated", - "decrease", - "opposite", - "structural", - "selected", - "stabilization", - "sites", - "localized", - "importance", + "beta", + "chain", + "used", + "instead", + "suggests", + "choose", + "apply", "cysteine", - "valine", - "accessible", + "diversity", + "appropriate", "also", - "novo", + "prediction", + "isoleucine", "driven", + "amino", + "trpzip", + "propensities", + "immediately", + "allows", + "backbone", + "multistranded", "peptides", - "apply", + "developed", + "cx", + "present", + "unique", + "contributions", + "measurement", + "cooperative", + "analysis", + "particular", + "often", + "indicate", + "association", + "structures", + "de", + "emphasizes", + "previously", + "hairpin", + "concept", + "structure", + "accessibility", + "host", + "nmr", + "interactions", + "typical", + "find", + "coiled", + "strand", "proven", - "residues", - "scaffold", - "explain", - "preceding", - "protein", - "residue", - "isoleucine", - "backbone", - "differences", + "difficult", + "favorable", + "conformations", + "solvent", + "studies", + "position", + "unexpected", + "libraries", "contribution", - "hairpins", - "hairpin", - "beta", - "side", - "emphasizes", - "folding", - "relative", - "developed", - "libraries" + "decrease", + "8" ], "release_date":"2003-02-04", "publication":"\"Stability of Cyclic Beta-Hairpins: Asymmetric Contributions From Side Chains of Hydrogen Bonded Cross-Strand Residue Pair\", J.Am.Chem.Soc., 125, 388-395", @@ -8711,102 +8712,102 @@ "structural protein" ], "keywords":[ - "containing", - "analysis", - "monomeric", - "results", - "constructs", - "studies", - "architecture", - "thermostability", - "thus", - "suggest", - "nonconserved", - "idealized", - "acid", - "designed", - "contains", - "clustered", - "sequences", - "position", + "repeats", + "engineering", + "molecular", + "recognition", "adopt", - "packed", - "structure", - "display", + "structural", + "resolution", "repeat", - "designated", - "database", - "novel", - "molecule", - "interaction", - "statistical", - "proteins", - "4ank", - "family", - "used", - "serve", - "degree", - "recognition", - "motif", - "nature", - "occurring", - "effective", - "naturally", + "information", + "idealized", "three", - "tightly", + "acid", + "results", + "topologies", + "dissecting", + "binding", + "motif", + "site", + "generic", + "demonstrate", "motifs", - "mediated", - "shows", + "two", "rules", - "consensus", - "pfam", - "series", - "molecular", - "amino", - "respectively", - "common", - "dissecting", - "resolution", - "four", - "topologies", - "define", - "information", - "method", - "mapping", - "functions", - "prototypes", - "engineering", - "crystallographic", - "design", "using", - "defines", - "required", - "surface", - "high", - "sequence", - "repeats", + "occurring", "extract", + "complex", + "defines", + "shows", + "respectively", + "define", + "thus", "biological", - "3ank", - "generic", - "structural", - "demonstrate", - "one", + "residues", + "family", + "functions", + "nonconserved", + "tightly", "approach", - "fold", - "understand", + "proteins", + "4ank", + "consensus", "modular", "ankyrin", - "residues", - "two", + "architecture", + "degree", + "contains", + "suggest", + "four", + "required", + "pfam", + "molecule", + "surface", + "effective", + "design", + "packed", + "used", + "display", + "mapping", "approximately", + "fold", + "clustered", + "amino", + "conservation", + "interaction", + "series", + "sequence", + "common", + "designated", + "crystallographic", + "method", + "designed", + "analysis", "determinants", - "binding", + "naturally", + "sequences", + "one", + "constructs", + "understand", + "structure", + "monomeric", + "thermostability", + "serve", + "nature", + "biophysical", "regular", - "complex", - "conservation", - "site", - "biophysical" + "mediated", + "high", + "3ank", + "studies", + "position", + "database", + "prototypes", + "containing", + "novel", + "statistical" ], "release_date":"2003-01-28", "publication":"\"Consensus-derived structural determinants of the ankyrin repeat motif\", Proc.Natl.Acad.Sci.USA, 99, 16029-16034", @@ -9138,102 +9139,102 @@ "structural protein" ], "keywords":[ - "containing", - "analysis", - "monomeric", - "results", - "constructs", - "studies", - "architecture", - "thermostability", - "thus", - "suggest", - "nonconserved", - "idealized", - "acid", - "designed", - "contains", - "clustered", - "sequences", - "position", + "repeats", + "engineering", + "molecular", + "recognition", "adopt", - "packed", - "structure", - "display", + "structural", + "resolution", "repeat", - "designated", - "database", - "novel", - "molecule", - "interaction", - "statistical", - "proteins", - "4ank", - "family", - "used", - "serve", - "degree", - "recognition", - "motif", - "nature", - "occurring", - "effective", - "naturally", + "information", + "idealized", "three", - "tightly", + "acid", + "results", + "topologies", + "dissecting", + "binding", + "motif", + "site", + "generic", + "demonstrate", "motifs", - "mediated", - "shows", + "two", "rules", - "consensus", - "pfam", - "series", - "molecular", - "amino", - "respectively", - "common", - "dissecting", - "resolution", - "four", - "topologies", - "define", - "information", - "method", - "mapping", - "functions", - "prototypes", - "engineering", - "crystallographic", - "design", "using", - "defines", - "required", - "surface", - "high", - "sequence", - "repeats", + "occurring", "extract", + "complex", + "defines", + "shows", + "respectively", + "define", + "thus", "biological", - "3ank", - "generic", - "structural", - "demonstrate", - "one", + "residues", + "family", + "functions", + "nonconserved", + "tightly", "approach", - "fold", - "understand", + "proteins", + "4ank", + "consensus", "modular", "ankyrin", - "residues", - "two", + "architecture", + "degree", + "contains", + "suggest", + "four", + "required", + "pfam", + "molecule", + "surface", + "effective", + "design", + "packed", + "used", + "display", + "mapping", "approximately", + "fold", + "clustered", + "amino", + "conservation", + "interaction", + "series", + "sequence", + "common", + "designated", + "crystallographic", + "method", + "designed", + "analysis", "determinants", - "binding", + "naturally", + "sequences", + "one", + "constructs", + "understand", + "structure", + "monomeric", + "thermostability", + "serve", + "nature", + "biophysical", "regular", - "complex", - "conservation", - "site", - "biophysical" + "mediated", + "high", + "3ank", + "studies", + "position", + "database", + "prototypes", + "containing", + "novel", + "statistical" ], "release_date":"2003-01-28", "publication":"\"Consensus-derived structural determinants of the ankyrin repeat motif\", Proc.Natl.Acad.Sci.USA, 99, 16029-16034", @@ -9402,63 +9403,63 @@ ], "subtitle":"Design of stable alpha-helical arrays from an idealized tpr motif", "tags":[ - "tpr", "de novo protein", - "design" + "design", + "tpr" ], "keywords":[ - "stability", - "statistical", - "framework", - "future", + "designed", + "superhelical", "analysis", - "designs", - "functional", - "proteins", + "design", "specificity", - "approach", + "structural", + "repeat", + "tpr", + "provides", + "structures", + "functional", "idealized", - "stable", - "although", + "different", "detailed", + "three", + "properties", "acid", - "designed", - "constructed", - "may", - "tandem", - "different", - "tetratricopeptide", - "motif", - "crystal", - "provides", - "design", - "tpr", - "300", - "interactions", + "framework", + "although", + "give", + "occurs", "occur", - "arrays", + "interactions", "protein", - "present", - "structures", - "helical", - "superhelical", - "describe", - "solution", - "three", "function", - "repeat", - "underlying", + "stability", + "approach", "sixteen", - "motifs", - "give", - "twists", "understanding", - "mediate", - "occurs", + "proteins", + "helical", + "tetratricopeptide", "binding", - "structural", + "solution", + "constructed", + "motif", + "mediate", + "tandem", + "may", + "arrays", + "underlying", + "300", + "motifs", "repeated", - "properties" + "present", + "crystal", + "twists", + "stable", + "describe", + "future", + "designs", + "statistical" ], "release_date":"2003-06-03", "publication":"\"Design of Stable alpha-Helical Arrays from an Idealized TPR Motif\", Structure, 11, 497-508", @@ -9562,63 +9563,63 @@ ], "subtitle":"Design of stable alpha-helical arrays from an idealized tpr motif", "tags":[ - "tpr", "de novo protein", - "design" + "design", + "tpr" ], "keywords":[ - "stability", - "statistical", - "framework", - "future", + "designed", + "superhelical", "analysis", - "designs", - "functional", - "proteins", + "design", "specificity", - "approach", + "structural", + "repeat", + "tpr", + "provides", + "structures", + "functional", "idealized", - "stable", - "although", + "different", "detailed", + "three", + "properties", "acid", - "designed", - "constructed", - "may", - "tandem", - "different", - "tetratricopeptide", - "motif", - "crystal", - "provides", - "design", - "tpr", - "300", - "interactions", + "framework", + "although", + "give", + "occurs", "occur", - "arrays", + "interactions", "protein", - "present", - "structures", - "helical", - "superhelical", - "describe", - "solution", - "three", "function", - "repeat", - "underlying", + "stability", + "approach", "sixteen", - "motifs", - "give", - "twists", "understanding", - "mediate", - "occurs", + "proteins", + "helical", + "tetratricopeptide", "binding", - "structural", + "solution", + "constructed", + "motif", + "mediate", + "tandem", + "may", + "arrays", + "underlying", + "300", + "motifs", "repeated", - "properties" + "present", + "crystal", + "twists", + "stable", + "describe", + "future", + "designs", + "statistical" ], "release_date":"2003-06-03", "publication":"\"Design of Stable alpha-Helical Arrays from an Idealized TPR Motif\", Structure, 11, 497-508", @@ -9722,120 +9723,120 @@ ], "subtitle":"Solution structure of a four-helix bundle model, apo-df1", "tags":[ - "unknown function", - "alpha-helical bundle", "de novo protein design", - "diiron protein model" + "alpha-helical bundle", + "diiron protein model", + "unknown function" ], "keywords":[ - "proximal", - "nm", - "kcalmol", - "critically", + "dimers", + "hydrophobic", + "structural", + "cavity", + "derivative", + "metalloprotein", "idealized", - "metal", - "ions", - "crystallographically", - "examined", + "within", + "model", + "protein", + "increased", + "binding", + "dissociation", + "equilibrium", + "thermodynamic", + "site", + "novo", + "manner", + "rotation", "test", - "designed", - "consequences", - "determine", - "dimeric", + "examined", + "apo", + "expected", + "channel", "crystal", - "features", - "ii", - "energetic", - "equilibrium", - "access", - "structure", - "monomer", - "building", - "increases", + "attractive", + "stable", + "helices", "k", - "proteins", - "solved", - "resembling", "similar", - "de", - "enzymes", - "although", - "characterized", - "manner", - "resulting", - "small", - "highly", - "site", - "fm", - "preorganized", - "folded", - "cavity", + "deltadeltag", "introduction", - "df1", - "center", - "natural", - "solution", - "function", - "derivative", - "compared", - "molecules", - "properties", - "previously", "delineate", - "metalloprotein", - "monomers", - "expected", + "characterized", + "metal", + "dueferri", + "access", + "overall", + "residues", + "increases", + "although", + "folded", + "approach", + "bound", + "proteins", "large", - "associated", + "sites", + "crystallographically", + "ions", "blocked", + "enzymes", + "center", + "highly", + "small", + "resembling", + "fm", "extent", - "diss", - "class", - "thermodynamic", - "increased", - "1", - "active", - "closely", - "diiron", - "apo", - "provides", - "bundle", - "dimanganese", - "design", - "model", + "monomer", + "features", "introduced", - "rotation", + "bundle", "required", - "hydrophobic", - "nmr", - "constant", + "1", + "kcalmol", + "design", + "critically", "bulky", - "dueferri", - "structural", - "dissociation", - "sites", - "overall", - "one", - "helices", - "approach", - "also", - "novo", - "stable", - "attractive", - "channel", + "compared", + "exists", + "active", + "provides", + "energetic", + "accommodate", + "natural", + "absence", + "monomers", + "properties", + "nm", "fold", + "df1", + "consequences", + "also", + "solution", + "building", + "diss", + "solved", "unfolded", - "residues", - "deltadeltag", + "determine", + "associated", + "dimanganese", + "designed", + "diiron", + "one", + "de", + "previously", + "proximal", + "structure", "subsequently", - "absence", - "dimers", - "exists", - "protein", - "bound", - "within", - "accommodate", - "binding" + "resulting", + "closely", + "nmr", + "function", + "class", + "molecules", + "constant", + "preorganized", + "dimeric", + "ii" ], "release_date":"2003-03-25", "publication":"\"Preorganization of molecular binding sites in designed diiron proteins\", Proc.Natl.Acad.Sci.USA, 100, 3772-3777", @@ -9949,115 +9950,115 @@ ], "subtitle":"Crystal structure of four-helix bundle model di-mn(ii)-df1-l13", "tags":[ - "alpha-helical bundle", "de novo protein", + "alpha-helical bundle", "protein design" ], "keywords":[ - "analysis", - "independent", - "restricted", + "recognition", "steric", + "whose", + "distance", + "number", + "polarity", + "cavity", + "23", + "tilting", + "side", + "affect", + "ligands", + "parameters", + "residue", + "model", + "protein", "carboxylates", - "metal", - "ions", - "crystallographically", - "determine", - "dimensions", - "flexibility", - "determined", + "motif", + "defining", + "together", + "site", + "novo", + "depends", + "two", + "chains", "geometric", - "ii", - "intermetal", + "differ", "conformation", - "df", - "access", - "23", - "minimal", + "flexibility", + "metal", + "bridging", + "formed", + "intermetal", + "soluble", "bulk", - "modulates", - "primary", + "metalloproteins", + "access", + "coordinated", "increases", - "forces", - "torsional", - "derivatives", - "determines", + "helix", + "stability", + "bound", "proteins", - "solved", - "defining", - "de", - "variants", - "number", - "substrate", - "recognition", - "motif", - "cavity", - "methane", - "whose", - "structures", - "center", - "df1", - "natural", - "coordinated", - "involves", + "crystallographically", + "ions", "size", - "ligands", - "affect", - "compared", - "first", - "previously", - "properties", - "stability", - "glu", - "bridging", - "additionally", - "depends", - "chemical", - "geometry", - "report", - "accessibility", + "center", "may", - "mode", - "active", + "chemical", + "restricted", + "analyzed", + "bundle", + "critical", + "methane", + "compared", "movement", - "diiron", - "sliding", - "monodentate", - "polarity", + "active", "provides", - "bundle", - "dimanganese", - "model", - "distance", - "soluble", - "parameters", + "natural", + "substrate", + "derivatives", + "properties", + "dinuclear", + "df1", + "monodentate", "collection", - "differ", - "chains", - "critical", - "exogenous", - "motion", - "homodimeric", - "novo", - "metalloproteins", - "analyzed", - "together", - "monooxygenase", - "two", + "independent", "chelating", - "evaluation", - "implications", - "protein", - "bound", - "tilting", - "residue", - "dinuclear", + "sliding", + "mode", + "modulates", + "glu", + "forces", + "primary", "backbone", - "helix", + "solved", "relationship", - "side", - "site", - "formed" + "df", + "implications", + "determine", + "minimal", + "dimanganese", + "motion", + "torsional", + "analysis", + "diiron", + "involves", + "dimensions", + "evaluation", + "geometry", + "variants", + "structures", + "de", + "monooxygenase", + "first", + "previously", + "accessibility", + "report", + "determined", + "additionally", + "exogenous", + "homodimeric", + "determines", + "ii" ], "release_date":"2004-05-18", "publication":"\"Response of a designed metalloprotein to changes in metal ion coordination, exogenous ligands, and active site volume determined by X-ray crystallography\", J.Am.Chem.Soc., 127, 17266-17276", @@ -10182,115 +10183,115 @@ ], "subtitle":"Crystal structure of four-helix bundle model di-co(ii)-df1-l13a (form i)", "tags":[ - "alpha-helical bundle", "de novo protein", + "alpha-helical bundle", "protein design" ], "keywords":[ - "analysis", - "independent", - "restricted", + "recognition", "steric", + "whose", + "distance", + "number", + "polarity", + "cavity", + "23", + "tilting", + "side", + "affect", + "ligands", + "parameters", + "residue", + "model", + "protein", "carboxylates", - "metal", - "ions", - "crystallographically", - "determine", - "dimensions", - "flexibility", - "determined", + "motif", + "defining", + "together", + "site", + "novo", + "depends", + "two", + "chains", "geometric", - "ii", - "intermetal", + "differ", "conformation", - "df", - "access", - "23", - "minimal", + "flexibility", + "metal", + "bridging", + "formed", + "intermetal", + "soluble", "bulk", - "modulates", - "primary", + "metalloproteins", + "access", + "coordinated", "increases", - "forces", - "torsional", - "derivatives", - "determines", + "helix", + "stability", + "bound", "proteins", - "solved", - "defining", - "de", - "variants", - "number", - "substrate", - "recognition", - "motif", - "cavity", - "methane", - "whose", - "structures", - "center", - "df1", - "natural", - "coordinated", - "involves", + "crystallographically", + "ions", "size", - "ligands", - "affect", - "compared", - "first", - "previously", - "properties", - "stability", - "glu", - "bridging", - "additionally", - "depends", - "chemical", - "geometry", - "report", - "accessibility", + "center", "may", - "mode", - "active", + "chemical", + "restricted", + "analyzed", + "bundle", + "critical", + "methane", + "compared", "movement", - "diiron", - "sliding", - "monodentate", - "polarity", + "active", "provides", - "bundle", - "dimanganese", - "model", - "distance", - "soluble", - "parameters", + "natural", + "substrate", + "derivatives", + "properties", + "dinuclear", + "df1", + "monodentate", "collection", - "differ", - "chains", - "critical", - "exogenous", - "motion", - "homodimeric", - "novo", - "metalloproteins", - "analyzed", - "together", - "monooxygenase", - "two", + "independent", "chelating", - "evaluation", - "implications", - "protein", - "bound", - "tilting", - "residue", - "dinuclear", + "sliding", + "mode", + "modulates", + "glu", + "forces", + "primary", "backbone", - "helix", + "solved", "relationship", - "side", - "site", - "formed" + "df", + "implications", + "determine", + "minimal", + "dimanganese", + "motion", + "torsional", + "analysis", + "diiron", + "involves", + "dimensions", + "evaluation", + "geometry", + "variants", + "structures", + "de", + "monooxygenase", + "first", + "previously", + "accessibility", + "report", + "determined", + "additionally", + "exogenous", + "homodimeric", + "determines", + "ii" ], "release_date":"2004-04-06", "publication":"\"Response of a designed metalloprotein to changes in metal ion coordination, exogenous ligands, and active site volume determined by X-ray crystallography\", J.Am.Chem.Soc., 127, 17266-17276", @@ -10423,115 +10424,115 @@ ], "subtitle":"Crystal structure of four-helix bundle model di-co(ii)-df1-l13a (form ii)", "tags":[ - "alpha-helical bundle", "de novo protein", + "alpha-helical bundle", "protein design" ], "keywords":[ - "analysis", - "independent", - "restricted", + "recognition", "steric", + "whose", + "distance", + "number", + "polarity", + "cavity", + "23", + "tilting", + "side", + "affect", + "ligands", + "parameters", + "residue", + "model", + "protein", "carboxylates", - "metal", - "ions", - "crystallographically", - "determine", - "dimensions", - "flexibility", - "determined", + "motif", + "defining", + "together", + "site", + "novo", + "depends", + "two", + "chains", "geometric", - "ii", - "intermetal", + "differ", "conformation", - "df", - "access", - "23", - "minimal", + "flexibility", + "metal", + "bridging", + "formed", + "intermetal", + "soluble", "bulk", - "modulates", - "primary", + "metalloproteins", + "access", + "coordinated", "increases", - "forces", - "torsional", - "derivatives", - "determines", + "helix", + "stability", + "bound", "proteins", - "solved", - "defining", - "de", - "variants", - "number", - "substrate", - "recognition", - "motif", - "cavity", - "methane", - "whose", - "structures", - "center", - "df1", - "natural", - "coordinated", - "involves", + "crystallographically", + "ions", "size", - "ligands", - "affect", - "compared", - "first", - "previously", - "properties", - "stability", - "glu", - "bridging", - "additionally", - "depends", - "chemical", - "geometry", - "report", - "accessibility", + "center", "may", - "mode", - "active", + "chemical", + "restricted", + "analyzed", + "bundle", + "critical", + "methane", + "compared", "movement", - "diiron", - "sliding", - "monodentate", - "polarity", + "active", "provides", - "bundle", - "dimanganese", - "model", - "distance", - "soluble", - "parameters", + "natural", + "substrate", + "derivatives", + "properties", + "dinuclear", + "df1", + "monodentate", "collection", - "differ", - "chains", - "critical", - "exogenous", - "motion", - "homodimeric", - "novo", - "metalloproteins", - "analyzed", - "together", - "monooxygenase", - "two", + "independent", "chelating", - "evaluation", - "implications", - "protein", - "bound", - "tilting", - "residue", - "dinuclear", + "sliding", + "mode", + "modulates", + "glu", + "forces", + "primary", "backbone", - "helix", + "solved", "relationship", - "side", - "site", - "formed" + "df", + "implications", + "determine", + "minimal", + "dimanganese", + "motion", + "torsional", + "analysis", + "diiron", + "involves", + "dimensions", + "evaluation", + "geometry", + "variants", + "structures", + "de", + "monooxygenase", + "first", + "previously", + "accessibility", + "report", + "determined", + "additionally", + "exogenous", + "homodimeric", + "determines", + "ii" ], "release_date":"2004-04-06", "publication":"\"Response of a designed metalloprotein to changes in metal ion coordination, exogenous ligands, and active site volume determined by X-ray crystallography\", J.Am.Chem.Soc., 127, 17266-17276", @@ -10647,129 +10648,129 @@ ], "subtitle":"Solution structure of s-824, a de novo designed four helix bundle", "tags":[ - "de novo design", "de novo protein", - "protein", - "four helix bundle" + "four helix bundle", + "de novo design", + "protein" ], "keywords":[ - "evolution", - "ordered", - "results", - "specifies", - "must", - "strategy", + "specified", + "hydrophobic", + "structural", + "show", + "well", + "question", "pattern", + "screens", + "side", + "simultaneously", + "patterned", + "randomly", "acid", - "including", - "determination", - "abundant", - "designed", + "polypeptide", + "results", + "strategy", + "protein", + "collections", + "source", + "exposing", + "periodicity", + "novo", + "forms", + "vast", + "isolated", + "secondary", + "computer", + "chains", + "focused", + "producing", + "binary", + "however", "enhance", - "generated", - "patterning", - "randomly", - "requires", - "determine", - "provide", - "favor", + "molten", + "determination", + "interior", "experimentally", - "determined", - "features", - "show", - "sequences", - "findings", - "rarely", - "regions", - "interactions", + "selected", "priori", - "validate", - "designing", - "structure", - "molten", - "diversity", - "burying", - "exposing", + "neither", "hydrophilic", - "recently", - "rich", - "however", - "novel", - "isolated", - "binary", + "polar", + "library", + "buried", + "folded", "proteins", - "unique", + "constructed", + "packing", "combinatorial", - "screens", - "de", - "source", - "nonetheless", + "answer", + "contain", + "subjected", + "evolution", + "features", "demonstrating", - "used", - "periodicity", - "folded", + "identities", + "bundle", + "favor", + "regions", + "including", + "unambiguous", + "na\u00efve", + "designing", "effective", - "structures", - "buried", - "likely", - "neither", - "form", - "simultaneously", - "solvent", - "exposed", - "quality", - "specified", + "design", + "spectroscopy", + "must", + "used", + "rich", + "fold", + "diversity", "amino", + "nonpolar", + "validate", + "backbone", "globule", - "detailed", + "sequence", + "requires", + "encode", + "3d", + "nonetheless", + "determine", + "unique", "screening", - "acids", "method", - "producing", + "burying", + "designed", + "form", + "directed", + "sequences", + "space", + "exposed", + "structures", + "de", + "detailed", + "likely", + "structure", "dictated", - "bundle", - "unambiguous", - "design", - "encode", - "polypeptide", - "hydrophobic", - "secondary", + "provide", + "determined", + "patterning", + "findings", + "recently", "nmr", - "sequence", - "packing", - "structural", - "selected", - "identities", - "library", - "3d", - "nonpolar", - "question", - "patterned", - "collections", - "chains", - "answer", - "novo", - "directed", - "fold", - "discovery", - "constructed", - "well", - "focused", - "spectroscopy", - "polar", - "na\u00efve", - "protein", + "interactions", "yield", - "backbone", - "space", - "vast", - "interior", - "computer", - "subjected", - "side", - "forms", - "contain", - "libraries" + "rarely", + "abundant", + "specifies", + "generated", + "acids", + "discovery", + "libraries", + "solvent", + "quality", + "ordered", + "novel" ], "release_date":"2003-11-11", "publication":"\"Solution structure of a de novo protein from a designed combinatorial library\", Proc.Natl.Acad.Sci.Usa, 100, 13270-13273", @@ -10856,83 +10857,84 @@ ], "classification":"unknown", "classification_suggested":[ - "minimal" + "minimal", + "rational" ], "classification_suggested_reason":[ "Dek's classification: small, non-systematic, and other" ], "subtitle":"De novo designed peptide-metalloporphyrin complex, solution structure", "tags":[ - "de novo protein", - "peptide; metalloporphyrin; heme; de novo design" + "peptide; metalloporphyrin; heme; de novo design", + "de novo protein" ], "keywords":[ - "series", - "weakly", - "thermal", - "toward", - "unfolding", + "affinity", + "designed", + "complex", + "goal", + "reactivity", + "finally", + "behavior", + "negatively", + "structural", + "show", + "spectroscopy", "coiii", - "confirm", - "prepared", - "restraints", - "cyclic", - "feiii", - "neutral", - "functional", - "additionally", - "metalloporphyrins", - "spectra", - "chemical", "de", - "novo", - "detailed", + "well", + "functional", "metalloproteins", - "experiments", - "experimental", - "isodichroic", - "negatively", "determination", - "reactivity", - "peptides", - "designed", - "together", - "goal", "positively", - "peptide", + "experimental", + "prepared", + "detailed", "presence", - "cd", - "finally", - "spectroscopy", - "well", - "provide", - "found", - "dispersed", - "binds", - "specific", - "behavior", - "metalloporphyrin", "becomes", - "show", - "produced", - "characterization", - "helical", + "properties", + "structure", + "specific", + "provide", + "experiments", + "additionally", + "isodichroic", + "cd", + "cyclic", + "spectra", + "thermal", + "nmr", "protein", "bind", - "complex", - "charged", - "nmr", + "understanding", + "neutral", + "helical", "solution", - "structure", + "unfolding", + "characterization", + "anionic", + "weakly", + "together", + "produced", + "series", + "charged", + "novo", "high", - "relationship", - "understanding", - "affinity", + "metalloporphyrins", "complexed", - "structural", - "anionic", - "properties", - "whereas" + "peptides", + "relationship", + "found", + "confirm", + "toward", + "metalloporphyrin", + "chemical", + "whereas", + "dispersed", + "binds", + "restraints", + "feiii", + "peptide" ], "release_date":"2003-12-09", "publication":"\"De novo designed cyclic-peptide heme complexes\", Proc.Natl.Acad.Sci.USA, 100, 13140-13145", @@ -11021,10 +11023,11 @@ "classification_suggested":[ "engineered", "rational", + "rational", "computational", "physics-based", - "computational", - "consensus" + "consensus", + "computational" ], "classification_suggested_reason":[ "Dek's classification: engineered", @@ -11033,122 +11036,122 @@ "subtitle":"Computationally designed peptide with a beta-beta-alpha fold selection, nmr, 32 structures", "tags":[ "dead end elimination", + "beta-beta-alpha fold", "designed peptide", "protein design", - "sequence optimization", - "beta-beta-alpha fold" + "sequence optimization" ], "keywords":[ - "thermal", - "28", - "unfolding", - "monomeric", - "developing", - "combined", - "metal", - "search", - "peptide", - "test", - "designed", - "determine", - "40", - "experimentally", - "methods", "limited", - "target", - "based", - "elimination", - "expand", - "module", - "structure", - "betabetaalpha", - "applied", - "algorithm", - "general", - "excellent", - "typified", - "solved", - "dna", + "0", + "methods", + "experimental", + "core", + "scoring", + "deviation", "elements", - "parts", - "less", - "goal", - "organization", - "resulting", - "highly", - "quantitative", - "motif", - "published", - "boundary", - "folded", - "buried", + "developing", + "betabetaalpha", + "protein", "positions", - "solution", - "tertiary", + "binding", + "unfolding", + "motif", "showed", - "atomic", - "physical", - "motifs", + "general", + "test", "circular", - "pda8d", - "transition", - "measurements", - "shows", - "solvent", - "exposed", - "previously", - "properties", - "stability", + "motifs", + "secondary", "theorem", - "weakly", - "homology", - "functions", "optimal", + "using", + "methodology", + "tertiary", + "goal", + "shows", + "metal", + "organization", + "algorithms", + "soluble", + "experimentally", + "28", + "dna", + "superposition", + "residues", "specific", - "55", + "transition", + "typified", + "functions", + "thermal", + "buried", + "folded", + "stability", + "combined", + "approach", + "20", + "published", + "sites", "several", - "superposition", - "design", - "core", - "scoring", - "soluble", - "using", - "cooperative", - "secondary", - "nmr", - "surface", - "sequence", - "rms", - "known", + "highly", + "contain", "ensemble", - "range", - "sites", + "physical", + "boundary", + "computational", + "peptide", + "55", + "zinc", + "measurements", + "surface", + "design", + "atomic", "finger", - "cysteine", + "40", "tested", + "properties", + "cysteine", + "parts", "groups", - "chose", - "approach", - "experimental", + "solution", + "algorithm", + "weakly", + "backbone", + "applied", + "sequence", + "solved", + "expand", + "excellent", + "developed", + "range", + "determine", + "rms", "desired", - "deviation", - "zinc", - "residues", "folds", + "cooperative", + "designed", + "search", + "chose", + "sought", + "exposed", + "previously", + "based", + "pda8d", + "structure", + "module", + "monomeric", + "resulting", + "elimination", + "target", + "nmr", + "known", "systematic", "objective", - "sought", - "protein", - "0", - "backbone", - "algorithms", - "computational", - "methodology", - "20", + "quantitative", "dichroism", - "binding", - "developed", - "contain" + "solvent", + "less", + "homology" ], "release_date":"1998-01-28", "publication":"\"De novo protein design: towards fully automated sequence selection\", J.Mol.Biol., 273, 789-796", @@ -11255,123 +11258,130 @@ "classification_suggested":[ "engineered", "rational", + "rational", "computational", "physics-based", - "computational", "consensus", + "computational", "consensus", - "rational" + "rational", + "computational", + "physics-based", + "rational", + "computational", + "physics-based", + "consensus" ], "classification_suggested_reason":[ "Dek's classification: engineered" ], "subtitle":"Crystallographic structure of mimochrome iv", "tags":[ + "metal binding protein", "miniaturized metalloprotein", - "mad on the cobalt edge", - "metal binding protein" + "mad on the cobalt edge" ], "keywords":[ - "stereochemical", - "metal", - "intramolecular", - "peptide", - "test", - "iv", - "designed", + "engineering", + "mimochromes", + "structural", + "overcome", + "derivative", + "well", + "around", + "presence", + "patterned", + "folding", "cd", - "switch", - "retained", - "interchain", - "experimentally", - "diastereomer", + "model", + "protein", + "helical", + "following", + "showed", + "essential", + "coordination", + "axial", + "test", + "covalently", + "two", + "related", "crystal", - "features", - "overcome", - "interactions", + "attractive", + "intrachain", + "chains", + "consist", "conformation", - "diffraction", - "structure", + "characterized", "however", + "metal", + "lambda", + "metalloproteins", + "examine", + "experimentally", + "mimochrome", + "overall", "isomer", + "stability", + "approach", + "conforms", + "packing", + "characterization", + "described", + "may", + "diastereomer", + "iii", + "intramolecular", + "iv", "delta", - "solved", - "coordination", - "unique", - "characterized", - "presence", - "resulting", - "covalently", - "predominant", - "structures", - "solution", - "essential", - "function", + "found", + "extent", + "hemoglobin", + "features", "linked", - "showed", - "revealed", - "derivative", + "required", "pairs", - "form", - "co", + "peptide", + "uniqueness", + "diastereomers", + "solid", + "configuration", + "design", + "predominant", "compared", - "previously", + "preferred", + "provides", + "solution", + "pairing", + "formation", "series", - "stability", - "following", - "prototype", + "stereochemical", + "retained", + "deuteroporphyrin", + "solved", "common", - "extent", + "peptides", + "unique", + "miniaturized", + "co", + "form", + "designed", "strong", - "may", - "intrachain", - "iii", - "configuration", - "examine", - "engineering", - "provides", - "conforms", + "revealed", + "diffraction", "observed", - "design", - "model", - "characterization", - "helical", - "mimochrome", - "required", + "structures", + "previously", + "structure", + "resulting", "nmr", - "formation", - "around", - "packing", - "structural", - "ion", - "patterned", - "overall", - "chains", - "miniaturized", - "lambda", - "approach", - "described", - "deuteroporphyrin", - "metalloproteins", - "mimochromes", - "attractive", - "axial", - "peptides", - "preferred", - "solid", - "well", - "found", - "two", - "problem", + "interactions", "state", - "hemoglobin", - "protein", - "pairing", - "uniqueness", - "folding", - "related", - "consist", - "diastereomers" + "ion", + "function", + "prototype", + "interchain", + "switch", + "problem" ], "release_date":"2004-12-14", "publication":"\"Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV\", J.Biol.Inorg.Chem., 9, 1017-1027", @@ -11464,13 +11474,13 @@ ], "subtitle":"Solution structure of alpha2d", "tags":[ - "four-helix bundle", + "de novo design", + "de novo protein", "protein folding", - "bisecting u motif", + "four-helix bundle", "helix-turn-helix", - "de novo protein", - "protein design", - "de novo design" + "bisecting u motif", + "protein design" ], "keywords":[ "description", @@ -11583,59 +11593,59 @@ ], "subtitle":"Crystal structure of top7: a computationally designed protein with a novel fold", "tags":[ + "de novo protein", "computationally designed", "alpha-beta", - "de novo protein", "novel fold" ], "keywords":[ - "general", - "makes", - "arbitrarily", - "called", + "angstroms", + "design", "topology", - "proteins", - "large", - "iterates", - "similar", - "strategy", - "stable", - "challenge", - "chosen", - "exploration", - "fold", - "deviation", - "prediction", - "square", + "observed", "used", - "found", + "structures", + "creation", "yet", - "top7", - "universe", "experimentally", - "crystal", - "nature", - "ability", - "folded", - "extremely", - "observed", - "design", - "model", - "creation", - "regions", - "structures", - "protein", - "angstroms", - "equals", + "possible", + "deviation", "structure", - "sequence", + "called", + "fold", + "iterates", "mean", + "new", + "chosen", + "strategy", + "prediction", "root", - "computational", + "model", + "protein", + "makes", + "exploration", + "folded", + "nature", + "extremely", + "proteins", + "large", + "ability", + "general", + "universe", + "sequence", + "top7", + "found", "major", - "novel", - "possible", - "new" + "arbitrarily", + "crystal", + "stable", + "challenge", + "square", + "computational", + "equals", + "regions", + "similar", + "novel" ], "release_date":"2003-11-25", "publication":"\"Design of a Novel Globular Protein Fold with Atomic-Level Accuracy\", Science, 302, 1364-1368", @@ -11753,68 +11763,68 @@ "de novo design" ], "keywords":[ - "accord", - "twist", - "tetramer", - "predetermined", - "overall", - "matches", + "designed", + "superhelical", + "form", + "flexibility", + "breadth", + "advances", + "conformation", + "engineered", + "naturally", + "design", + "dimers", "specified", - "incorporated", - "proteins", - "algebraic", - "detail", - "lack", + "tetramer", + "atomic", + "methods", + "structures", "de", - "novo", - "described", - "oligomerization", - "family", + "enumerations", + "interior", + "allowed", + "overall", "detailed", - "tetramers", + "structure", "fold", - "peptides", - "designed", + "family", + "alternate", + "novel", "trimers", - "goals", + "incorporated", + "residue", + "algebraic", "patterning", - "engineered", - "enumerations", - "flexibility", - "parameterization", - "advances", - "methods", - "dimers", - "breadth", - "occurring", - "state", - "rotamers", - "crystal", - "bundle", - "design", + "matches", "model", "explore", - "structures", - "naturally", - "precise", + "state", "protein", - "superhelical", - "residue", - "conformation", + "goals", + "oligomerization", + "accord", + "proteins", + "packing", + "detail", "backbone", - "alternate", - "interior", + "occurring", + "described", + "novo", + "parameterization", + "twist", + "tetramers", + "rotamers", + "peptides", + "conformations", "recent", - "structure", - "atomic", - "allowed", + "precise", "techniques", + "predetermined", + "whereas", + "crystal", "computational", - "form", - "novel", - "packing", - "conformations", - "whereas" + "bundle", + "lack" ], "release_date":"1998-12-02", "publication":"\"High-resolution protein design with backbone freedom\", Science, 282, 1462-1467", @@ -11936,80 +11946,80 @@ "de novo protein" ], "keywords":[ - "disease", - "importance", - "disorders", + "reveal", + "designed", + "form", + "conformation", + "often", "molecular", + "disease", + "transform", "many", - "results", - "conditions", - "details", - "approach", - "ambient", - "study", - "process", - "report", + "however", + "structural", + "origins", + "show", "de", - "detailed", "rational", - "novo", - "debilitating", - "changes", - "origins", - "human", - "peptide", - "fibrils", + "interconversion", + "detailed", + "contribute", + "potential", + "relative", + "exceptionally", + "structure", + "specific", "fold", - "temperatures", - "designed", + "details", + "report", + "results", + "determined", + "disorders", "sensitive", + "model", + "complexity", + "probing", + "state", + "protein", + "study", "successfully", + "ambient", + "propose", + "interactions", + "approach", + "hinders", "kinetics", - "stabilities", + "packing", + "fibrils", + "process", + "formation", + "changes", + "size", + "conditions", + "novo", + "debilitating", + "polypeptides", + "amyloid", + "sequence", + "highly", "small", - "reveal", + "system", + "forms", "simplified", - "highly", - "hinders", "found", + "elevated", + "favorable", "two", - "specific", "crystal", - "system", - "often", - "determined", - "state", - "potential", - "fibrillar", - "show", - "model", - "amyloid", - "protein", - "interactions", - "conformation", - "exceptionally", - "propose", - "interconversion", - "complexity", - "transform", - "elevated", - "sequence", - "structure", - "underlies", - "size", "effects", - "formation", - "form", - "favorable", - "probing", - "however", - "polypeptides", - "contribute", + "temperatures", + "human", + "importance", "deposition", - "relative", - "structural", - "packing", - "forms" + "underlies", + "peptide", + "fibrillar", + "stabilities" ], "release_date":"2004-04-06", "publication":"\"Exploring amyloid formation by a de novo design\", Proc.Natl.Acad.Sci.USA, 101, 4435-4440", @@ -12108,82 +12118,82 @@ ], "subtitle":"An oligomeric domain-swapped beta-beta-alpha mini-protein", "tags":[ - "mini-protein", + "oligomerization", "de novo protein", - "protein design", + "mini-protein", "domain swapping", - "oligomerization" + "protein design" ], "keywords":[ - "associates", - "stability", - "thermal", - "anomalous", - "exchange", - "discrete", + "form", + "cooperative", + "surface", "tetramer", - "per", - "characteristics", - "possesses", - "many", - "proteins", - "larger", - "components", "defined", - "lack", + "limited", + "diffraction", + "beta", + "many", + "hydrophobic", "retain", "resolution", + "per", + "packed", "origins", - "sulfonate", - "elements", + "provides", + "analogs", + "well", + "uncharacterized", + "anomalous", + "core", + "previously", + "21", "area", - "peptide", - "including", - "means", - "1", + "oligomeric", + "structure", + "phasing", + "elements", + "possesses", + "determined", + "folding", + "quaternary", + "thermal", "insight", - "well", + "deuterium", + "means", + "biophysical", + "buried", "typical", - "analogs", - "miniprotein", + "tightly", + "stability", "interact", + "proteins", + "alpha", + "comprising", + "binding", + "oligomer", "aa", - "crystal", - "determined", - "limited", - "provides", - "core", - "21", - "multiwavelength", - "packed", - "cooperative", + "sulfonate", + "native", "adopts", - "secondary", + "including", + "components", "selenomethionine", - "diffraction", - "hydrophobic", + "larger", + "exchange", + "crystal", + "secondary", + "monomer", + "miniprotein", "shares", - "deuterium", - "structure", "unusual", - "surface", - "tightly", - "native", - "alpha", - "buried", - "beta", - "monomer", - "uncharacterized", - "comprising", - "form", - "oligomeric", - "oligomer", - "quaternary", - "folding", - "phasing", - "binding", - "biophysical", - "previously" + "associates", + "characteristics", + "1", + "peptide", + "discrete", + "lack", + "multiwavelength" ], "release_date":"2004-08-17", "publication":"\"X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture\", Proc.Natl.Acad.Sci.USA, 101, 12183-12188", @@ -12290,82 +12300,82 @@ ], "subtitle":"An oligomeric domain-swapped beta-beta-alpha mini-protein", "tags":[ - "mini-protein", + "oligomerization", "de novo protein", - "protein design", + "mini-protein", "domain swapping", - "oligomerization" + "protein design" ], "keywords":[ - "associates", - "stability", - "thermal", - "anomalous", - "exchange", - "discrete", + "form", + "cooperative", + "surface", "tetramer", - "per", - "characteristics", - "possesses", - "many", - "proteins", - "larger", - "components", "defined", - "lack", + "limited", + "diffraction", + "beta", + "many", + "hydrophobic", "retain", "resolution", + "per", + "packed", "origins", - "sulfonate", - "elements", + "provides", + "analogs", + "well", + "uncharacterized", + "anomalous", + "core", + "previously", + "21", "area", - "peptide", - "including", - "means", - "1", + "oligomeric", + "structure", + "phasing", + "elements", + "possesses", + "determined", + "folding", + "quaternary", + "thermal", "insight", - "well", + "deuterium", + "means", + "biophysical", + "buried", "typical", - "analogs", - "miniprotein", + "tightly", + "stability", "interact", + "proteins", + "alpha", + "comprising", + "binding", + "oligomer", "aa", - "crystal", - "determined", - "limited", - "provides", - "core", - "21", - "multiwavelength", - "packed", - "cooperative", + "sulfonate", + "native", "adopts", - "secondary", + "including", + "components", "selenomethionine", - "diffraction", - "hydrophobic", + "larger", + "exchange", + "crystal", + "secondary", + "monomer", + "miniprotein", "shares", - "deuterium", - "structure", "unusual", - "surface", - "tightly", - "native", - "alpha", - "buried", - "beta", - "monomer", - "uncharacterized", - "comprising", - "form", - "oligomeric", - "oligomer", - "quaternary", - "folding", - "phasing", - "binding", - "biophysical", - "previously" + "associates", + "characteristics", + "1", + "peptide", + "discrete", + "lack", + "multiwavelength" ], "release_date":"2004-08-17", "publication":"\"X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture\", Proc.Natl.Acad.Sci.Usa, 101, 12183-12188", @@ -12471,82 +12481,82 @@ ], "subtitle":"An oligomeric domain-swapped beta-beta-alpha mini-protein", "tags":[ - "mini-protein", + "oligomerization", "de novo protein", - "protein design", + "mini-protein", "domain swapping", - "oligomerization" + "protein design" ], "keywords":[ - "associates", - "stability", - "thermal", - "anomalous", - "exchange", - "discrete", + "form", + "cooperative", + "surface", "tetramer", - "per", - "characteristics", - "possesses", - "many", - "proteins", - "larger", - "components", "defined", - "lack", + "limited", + "diffraction", + "beta", + "many", + "hydrophobic", "retain", "resolution", + "per", + "packed", "origins", - "sulfonate", - "elements", + "provides", + "analogs", + "well", + "uncharacterized", + "anomalous", + "core", + "previously", + "21", "area", - "peptide", - "including", - "means", - "1", + "oligomeric", + "structure", + "phasing", + "elements", + "possesses", + "determined", + "folding", + "quaternary", + "thermal", "insight", - "well", + "deuterium", + "means", + "biophysical", + "buried", "typical", - "analogs", - "miniprotein", + "tightly", + "stability", "interact", + "proteins", + "alpha", + "comprising", + "binding", + "oligomer", "aa", - "crystal", - "determined", - "limited", - "provides", - "core", - "21", - "multiwavelength", - "packed", - "cooperative", + "sulfonate", + "native", "adopts", - "secondary", + "including", + "components", "selenomethionine", - "diffraction", - "hydrophobic", + "larger", + "exchange", + "crystal", + "secondary", + "monomer", + "miniprotein", "shares", - "deuterium", - "structure", "unusual", - "surface", - "tightly", - "native", - "alpha", - "buried", - "beta", - "monomer", - "uncharacterized", - "comprising", - "form", - "oligomeric", - "oligomer", - "quaternary", - "folding", - "phasing", - "binding", - "biophysical", - "previously" + "associates", + "characteristics", + "1", + "peptide", + "discrete", + "lack", + "multiwavelength" ], "release_date":"2004-08-17", "publication":"\"X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture\", Proc.Natl.Acad.Sci.Usa, 101, 12183-12188", @@ -12644,123 +12654,123 @@ ], "subtitle":"Nmr structure of bba5, a compact, independently folded bba motif", "tags":[ - "beta beta alpha", + "mini-protein", "de novo protein", "protein design", - "mini-protein" + "beta beta alpha" ], "keywords":[ - "bba4", - "analysis", - "manipulation", - "studies", - "bba5", + "highlighted", + "defined", + "adopt", + "role", + "additional", + "experimental", "bba6", - "undesired", + "bba2", "acid", - "increasing", - "peptide", - "including", - "designed", - "exterior", - "bba3", - "uses", - "flexibility", - "potential", - "based", - "ii", - "sequences", - "regions", - "synthetic", - "adopt", - "represented", - "structure", - "alpha", - "recently", - "turn", - "expanding", - "availability", - "structured", - "investigated", - "sheet", - "eliminated", - "small", - "tryptophan", - "highly", + "provided", + "tyrosine", + "polypeptide", + "replacing", + "residue", + "folding", + "insight", + "protein", + "bba7", "motif", - "folded", - "include", - "better", - "highlighted", "charged", - "natural", - "theoretical", - "tertiary", - "revealed", + "domains", + "polypeptides", + "systems", "motifs", + "two", + "ambiguity", "either", - "additional", - "role", - "systems", - "provided", - "reported", - "amino", - "defined", - "resulted", - "1", - "acids", - "simplified", + "tertiary", + "flexibility", + "select", + "engineered", + "conformational", + "creation", + "include", + "residues", "specific", - "bba1", - "ambiguity", - "bba7", - "constrains", - "stabilize", - "replacing", - "design", - "tyrosine", - "polypeptide", + "bba3", + "polar", + "bba4", + "led", + "folded", + "eliminated", "characterization", - "type", - "negative", - "nmr", + "exterior", + "highly", + "small", + "manipulation", + "stabilize", + "importance", + "regions", + "including", + "1", + "peptide", + "zinc", "surface", - "bba", + "theoretical", + "design", + "beta", + "critical", "involvement", - "led", - "bba2", - "importance", + "natural", + "concepts", + "bba1", + "absence", "finger", - "one", - "critical", - "conformational", - "also", - "experimental", - "desired", + "potential", + "fen", "fold", - "understand", + "also", + "bba", + "undesired", + "amino", + "type", + "alpha", + "resulted", + "constrains", + "reported", + "uses", "peptides", - "insight", - "select", - "zinc", - "engineered", - "residues", - "two", - "absence", + "simplified", + "expanding", + "desired", + "increasing", + "represented", + "designed", + "analysis", "determinants", + "revealed", + "sequences", + "one", + "investigated", "evaluation", - "polar", - "domains", - "creation", - "protein", - "residue", - "beta", - "hairpin", - "fen", - "polypeptides", - "folding", "loop", - "concepts" + "understand", + "based", + "hairpin", + "structured", + "structure", + "synthetic", + "availability", + "sheet", + "recently", + "nmr", + "negative", + "tryptophan", + "acids", + "turn", + "bba5", + "studies", + "better", + "ii" ], "release_date":"2004-05-25", "publication":"\"Design and NMR Analyses of Compact, Independently Folded BBA Motifs\", Fold.Des., 3, 95-103", @@ -12872,90 +12882,90 @@ "coiled coil; de novo design" ], "keywords":[ - "tetramer", - "steric", - "specificity", - "use", - "close", "trimer", + "driving", + "steric", + "structural", + "repeat", + "cavity", + "experimental", + "families", + "rationally", + "core", + "differs", + "simultaneously", + "phasing", + "within", "acid", - "designed", - "sensitive", - "requires", - "asymmetry", - "provide", - "11", - "principal", + "new", + "adopted", + "protein", + "rh4", + "source", + "unanticipated", + "close", + "site", "crystal", - "modeling", - "determined", - "position", - "interactions", + "indicates", + "using", "conformation", - "rh3", - "similarity", - "designing", - "structure", - "repeat", + "permitted", + "characterized", + "specificity", + "asymmetry", + "biological", + "overlap", "intended", - "oligomer", - "rh4", - "forces", - "coiled", - "allows", + "approach", "proteins", - "source", - "characterized", + "packing", + "use", + "11", + "designing", + "tetramer", + "design", + "another", "feature", "specify", - "cavity", - "structures", - "driving", - "coil", - "simultaneously", - "phasing", - "indicates", - "previously", - "data", - "another", + "fold", "amino", - "families", - "report", - "detailed", - "exploration", - "strong", - "method", - "permitted", - "observed", - "comparison", - "design", - "core", - "rationally", - "using", - "differs", - "sequence", - "biological", "formation", - "adopted", - "packing", - "structural", - "optimizing", - "one", + "forces", + "oligomer", + "allows", + "backbone", + "requires", + "sequence", "parameterized", - "approach", - "experimental", - "fold", - "unanticipated", - "problem", + "modeling", + "method", "folds", + "designed", + "strong", + "one", + "observed", + "structures", + "principal", + "previously", + "detailed", + "optimizing", + "structure", + "report", + "provide", + "determined", + "interactions", + "exploration", + "rh3", "systematic", + "coiled", + "coil", + "position", + "data", + "problem", + "similarity", "variation", - "protein", - "backbone", - "within", - "overlap", - "site", - "new" + "comparison", + "sensitive" ], "release_date":"2004-10-12", "publication":"\"Structural test of the parameterized-backbone method for protein design\", J.Mol.Biol., 342, 289-297", @@ -13062,12 +13072,12 @@ ], "subtitle":"Crystal structure of a high affinity lanthanide-binding peptide (lbt)", "tags":[ - "troponin based design", - "lanthanide-based resonance energy transfer", - "ef-hand", "fluorescence", "de novo protein", - "lanthanide binding tag" + "lanthanide-based resonance energy transfer", + "troponin based design", + "lanthanide binding tag", + "ef-hand" ], "keywords":[ "description", @@ -13186,68 +13196,68 @@ "coiled-coil" ], "keywords":[ - "stability", - "framework", - "domain", - "per", - "homology", - "restraints", - "archetypical", - "nm", - "heptad", - "solved", - "specificity", - "crossing", - "low", - "de", - "novo", - "stable", - "70", - "1", + "affinity", "designed", + "repeats", + "engineering", + "design", + "hydrophobic", + "structural", + "specificity", + "key", "electrostatic", + "provides", + "de", "well", - "interface", - "highly", + "core", + "previously", + "domain", "possessing", + "based", + "three", "subunit", - "visualizing", - "shown", - "engineering", + "70", + "nm", + "archetypical", + "structure", + "important", + "within", "heterodimer", - "determined", - "purification", - "provides", + "framework", "content", - "based", - "design", - "core", + "determined", + "combination", + "nmr", "interactions", "protein", - "using", - "applications", - "hydrophobic", - "nmr", + "contacts", + "shown", + "completely", + "stability", + "dissociation", "solution", - "structure", - "three", - "stabilized", - "repeats", - "high", - "constant", - "combination", - "within", - "key", "comprising", "formation", - "dissociation", - "affinity", - "completely", - "structural", - "important", - "contacts", - "direct", - "previously" + "low", + "novo", + "high", + "homology", + "highly", + "interface", + "solved", + "constant", + "purification", + "crossing", + "applications", + "visualizing", + "stable", + "restraints", + "using", + "stabilized", + "1", + "per", + "heptad", + "direct" ], "release_date":"2004-10-19", "publication":"\"NMR solution structure of a highly stable de novo heterodimeric coiled-coil\", Biopolymers, 75, 367-375", @@ -13346,118 +13356,118 @@ ], "subtitle":"Nmr solution structure of a designed heterodimeric leucine zipper", "tags":[ - "electrostatic interactions", - "leucine zipper", - "transcription", "coiled coil", - "inter-helical ion pairing" + "inter-helical ion pairing", + "leucine zipper", + "electrostatic interactions", + "transcription" ], "keywords":[ - "mhz", - "acidic", - "330", - "contributions", "ionizable", - "designed", - "homologous", - "basic", - "stabilities", - "determine", - "induced", - "interchain", - "based", - "residual", - "energetic", - "interactions", - "8", - "affected", + "individual", "therefore", - "structure", - "zipper", - "favorable", - "unfavorable", + "well", + "pk", "illustrates", - "coiled", - "chain", - "called", - "neutral", - "similar", - "h", - "indicated", - "involved", - "electrostatic", - "strongly", - "ab", - "yet", - "folded", - "charges", - "individual", - "structures", - "mol", - "charged", - "caused", - "coil", "affect", - "compared", - "2003", - "marti", + "parameters", + "folding", "strikingly", - "previously", - "stability", - "glu", + "protein", + "study", + "six", + "ph", "salt", - "data", - "biol", - "interhelical", - "600", - "higher", - "bridges", + "indicated", "thermodynamic", - "1", - "peaks", - "may", - "mainly", - "bosshard", + "charged", "collected", + "b", + "two", + "induced", + "stable", + "caused", + "chains", + "involved", + "330", + "similar", + "stabilities", "leucine", - "six", - "stabilize", + "heterodimeric", + "formed", + "600", + "due", "effect", - "nmr", - "parameters", - "formation", - "ph", - "ss", - "consisting", - "importance", - "chains", - "study", - "stable", - "contrast", - "pk", - "inverse", - "well", - "unfolded", + "relative", + "bridges", "residues", - "heterodimeric", - "different", + "unfavorable", + "strongly", + "folded", + "stability", + "2", + "converge", + "may", "found", + "zipper", + "higher", + "stabilize", + "importance", + "interhelical", + "1", "characterize", - "two", - "due", + "mainly", + "peaks", + "compared", + "chain", + "electrostatic", + "destabilize", + "energetic", + "yet", + "different", + "shifts", + "consisting", "approximately", + "called", + "charges", + "marti", + "mol", + "glu", + "ab", + "formation", + "contrast", + "residual", + "unfolded", + "evaluated", + "determine", + "contributions", + "designed", + "homologous", + "h", + "basic", + "structures", + "inverse", + "previously", + "based", + "structure", + "acidic", + "ss", + "affected", + "nmr", + "interactions", "state", + "mhz", + "neutral", "energetics", - "b", - "protein", - "2", - "shifts", - "evaluated", - "destabilize", - "converge", - "folding", - "relative", - "formed" + "coiled", + "coil", + "interchain", + "favorable", + "biol", + "data", + "2003", + "bosshard", + "8" ], "release_date":"2004-10-05", "publication":"\"Inverse electrostatic effect: electrostatic repulsion in the unfolded state stabilizes a leucine zipper\", Biochemistry, 43, 12436-12447", @@ -13553,46 +13563,46 @@ ], "subtitle":"A novel adp- and zinc-binding fold from function-directed in vitro evolution", "tags":[ - "nucleotide binding protein", "de novo protein", "in vitro evolution", - "artificial nucleotide binding protein" + "artificial nucleotide binding protein", + "nucleotide binding protein" ], "keywords":[ - "great", - "evolution", - "ligand", - "tailored", - "proteins", - "reveals", + "alternative", + "design", "investigated", + "targeted", + "tailored", "de", - "novo", - "challenge", - "fold", - "zinc", - "generated", + "first", + "atp", + "ligand", "randomly", + "structure", + "great", + "fold", + "stabilized", "functions", - "targeted", - "biologists", - "folds", - "atp", - "crystal", - "vitro", - "design", + "ion", "protein", + "representing", + "derived", "bind", "bound", - "derived", - "representing", - "structure", - "stabilized", - "first", - "novel", - "alternative", + "proteins", + "vitro", + "novo", + "biologists", + "reveals", + "generated", + "evolution", + "crystal", + "challenge", "create", - "ion" + "folds", + "novel", + "zinc" ], "release_date":"2004-03-26", "publication":"\"A Novel Adp- and Zinc-Binding Fold from Function-Directed in Vitro Evolution\", Nat.Struct.Mol.Biol., 11, 382", @@ -13625,7 +13635,7 @@ "seq_thr_sim_designed":[ { "sim":179.0, - "partner":"3lt9" + "partner":"3ltb" }, { "sim":179.0, @@ -13633,11 +13643,11 @@ }, { "sim":179.0, - "partner":"3ltb" + "partner":"3ltc" }, { "sim":179.0, - "partner":"3ltc" + "partner":"3lt9" }, { "sim":179.0, @@ -13682,7 +13692,7 @@ ], "seq_max_sim_designed":{ "sim":179.0, - "partner":"3lt9" + "partner":"3ltb" }, "seq_max_sim_natural":[ @@ -13731,89 +13741,89 @@ ], "subtitle":"Nucleophilic and general acid catalysis at physiological ph by a designed miniature esterase", "tags":[ - "hormone", "cleavage on pair of basic residues", - "pancreas" + "pancreas", + "hormone" ], "keywords":[ - "intermediate", + "kinetic", + "rate", + "pk", "acid", - "peptide", - "designed", - "value", - "generally", - "based", - "order", - "structure", - "esters", - "catalysis", - "fashion", - "interaction", - "bovine", - "pancreatic", - "esterases", - "catalysed", - "face", - "similar", - "enzymes", + "polypeptide", + "nucleophilicity", + "adopted", + "protonated", + "increased", + "mass", + "ph", "indicated", - "efficient", - "positively", - "dependence", - "interplay", + "act", + "acyl", "charged", - "natural", - "solution", + "confirmed", + "transparent", + "catalytic", + "two", + "stable", "miniature", - "transition", + "face", + "similar", + "reaction", + "value", + "positively", + "catalyse", + "effect", + "residues", "catalyst", - "second", - "solvent", + "transition", "consequence", - "transparent", - "exposed", - "amino", - "hydrolysis", - "acyl", - "catalytic", - "increased", - "constants", - "activity", - "rate", - "observed", + "led", + "generally", "several", - "polypeptide", + "interplay", + "enzymes", + "catalysed", + "peptide", + "values", + "pancreatic", + "preceding", + "spectroscopy", + "involvement", + "natural", + "behaviour", + "different", + "proceeded", + "amino", "reduced", - "effect", - "nmr", + "solution", + "interaction", + "esters", "stabilised", + "mechanism", + "dependence", + "catalysis", + "designed", + "constants", + "esterases", + "order", + "efficient", "histidine", - "ph", - "adopted", - "kinetic", - "involvement", - "led", - "protonated", - "nucleophilicity", - "values", - "stable", - "behaviour", - "pk", - "act", + "exposed", + "observed", + "hydrolysis", + "based", + "bovine", + "structure", "isotope", - "spectroscopy", - "confirmed", - "residues", - "different", - "reaction", - "two", + "nmr", "state", - "mechanism", - "proceeded", - "preceding", - "spectrometry", - "catalyse", - "mass" + "intermediate", + "fashion", + "activity", + "solvent", + "second", + "spectrometry" ], "release_date":"2005-04-14", "publication":"\"Nucleophilic and General Acid Catalysis at Physiological Ph by a Designed Miniature Esterase\", Org.Biomol.Chem., 2, 2175", @@ -13937,117 +13947,117 @@ "miniaturized metalloproteins" ], "keywords":[ - "use", - "metal", - "intramolecular", - "peptide", - "iv", - "shed", - "designed", - "diamagnetic", + "mimochromes", + "adopt", + "role", + "insights", + "derivative", + "modulating", + "metalloprotein", + "around", + "matrix", + "presence", + "new", + "heme", "cofactors", - "experimentally", - "support", + "model", + "leaves", + "protein", + "helical", + "confirmed", "diastereomeric", - "potential", - "obtain", - "order", - "interactions", - "suggested", - "adopt", + "systems", + "covalently", + "forms", + "composed", + "two", + "diamagnetic", + "stable", + "attractive", + "chains", + "similar", + "complex", "conformation", - "represent", - "c", - "structure", - "insights", + "shed", + "metal", "however", - "molecule", - "derivatives", - "spectroscopic", + "lambda", + "metalloproteins", + "experimentally", + "mimochrome", + "particularly", + "functions", + "favoring", + "changing", + "useful", + "derived", "isomer", - "composed", - "chain", - "topology", - "models", + "characterization", + "use", + "2", + "iii", + "intramolecular", + "isomers", + "iv", "delta", - "unique", - "similar", - "favoring", - "leaves", + "linked", + "advantageous", + "peptide", + "molecule", + "c", + "diastereomers", + "spectroscopic", + "redox", + "symmetry", + "design", "indeed", - "presence", + "topology", + "chain", + "help", + "provides", "used", "simple", - "covalently", - "symmetric", - "particularly", - "ability", - "derived", - "simplifies", - "solution", - "linked", - "derivative", - "revealed", - "co", - "stereochemically", - "first", - "role", - "systems", + "represent", + "possible", + "different", + "species", + "potential", "properties", - "metalloprotein", - "redox", - "useful", - "functions", - "iii", - "successful", + "simplifies", + "derivatives", "synthesis", - "help", - "provides", - "observed", - "design", - "model", - "characterization", - "helical", - "mimochrome", - "isomers", - "nmr", + "successful", "insertion", - "modulating", - "symmetry", + "light", + "symmetric", + "solution", "formation", - "around", "cobalt", - "ion", - "advantageous", - "chains", - "one", - "lambda", - "composition", - "stable", + "ability", "deuteroporphyrin", - "metalloproteins", - "mimochromes", - "attractive", - "understand", - "heme", "peptides", - "species", - "different", - "confirmed", - "changing", - "two", - "problem", - "light", - "iron", - "protein", - "2", - "complex", - "matrix", - "possible", + "suggested", "developed", - "forms", - "diastereomers", - "new" + "unique", + "obtain", + "co", + "designed", + "models", + "order", + "revealed", + "one", + "observed", + "understand", + "first", + "structure", + "nmr", + "ion", + "interactions", + "stereochemically", + "support", + "composition", + "problem", + "iron" ], "release_date":"2004-07-20", "publication":"\"Design of a New Mimochrome with Unique Topology\", Chemistry, 9, 5643-5654", @@ -14131,83 +14141,83 @@ ], "subtitle":"Helix turn helix motif", "tags":[ - "helix-turn-helix motif", + "hth", "de novo protein", - "hth" + "helix-turn-helix motif" ], "keywords":[ - "sites", - "without", - "prebiotic", - "stretches", - "early", + "designed", + "short", + "conformation", "molecular", - "expected", - "anion", - "incorporation", - "functional", - "long", - "proteins", - "frameworks", - "connected", - "helices", - "supports", - "conditions", - "remarkable", - "similar", - "bonds", - "de", - "novo", + "observation", + "design", "metal", - "ions", - "apolar", "linker", - "feature", - "peptide", - "peptides", - "designed", - "emergence", - "seen", - "useful", + "prebiotic", + "nest", + "help", + "structures", + "de", "supersecondary", - "unanticipated", + "functional", + "tetraglycine", + "feature", + "possible", + "apolar", + "21", + "hairpin", + "without", + "structure", "provide", - "region", + "determined", + "bonds", + "residue", + "combination", + "connected", + "folding", "functions", - "two", + "frameworks", + "seen", + "strikingly", + "supports", + "useful", + "function", "interact", - "motif", - "short", - "folds", - "crystal", - "help", - "occurrence", - "determined", - "rudimentary", - "several", - "design", + "sites", + "proteins", "helical", - "structures", - "realized", - "21", - "residue", "disulphide", + "remarkable", + "unanticipated", + "occurrence", + "anion", + "ions", "binding", - "conformation", - "view", - "structure", - "function", - "sequence", - "tetraglycine", - "either", - "combination", - "hairpin", - "folding", - "possible", + "motif", + "realized", + "several", + "rudimentary", + "conditions", + "novo", + "stretches", "hydrogen", - "observation", - "nest", - "strikingly" + "sequence", + "view", + "early", + "peptides", + "expected", + "emergence", + "two", + "crystal", + "region", + "incorporation", + "helices", + "long", + "folds", + "similar", + "peptide", + "either" ], "release_date":"2005-11-01", "publication":"\"De Novo Design and Characterization of a Helical Hairpin Eicosapeptide; Emergence of an Anion Receptor in the Linker Region\", Structure, 12, 389-396", @@ -14321,76 +14331,76 @@ ], "subtitle":"Heterooligomeric beta beta alpha miniprotein", "tags":[ - "heterotetramer", "de novo protein", "protein design", - "heterooligomer" + "heterooligomer", + "heterotetramer" ], "keywords":[ - "stability", + "relatively", + "designed", "convert", + "complex", "analysis", - "reported", - "advancing", + "models", + "complementarity", + "design", + "miniproteins", + "cooperatively", "many", "one", - "efficiently", - "models", - "reveals", - "thus", "specificity", + "structural", "steric", - "use", - "complementarity", - "study", - "report", - "described", - "although", - "screening", - "smallest", + "structures", + "platforms", + "homotetramer", + "simple", + "possible", + "combinations", + "thus", + "efficiently", + "important", + "synthetic", + "structure", "fold", - "peptides", - "designed", + "report", + "specific", "charge", - "successfully", - "patterning", "short", - "useful", - "simple", - "specific", - "crystal", - "platforms", - "far", - "design", - "encode", - "heterospecificity", - "autonomously", - "examples", - "structures", - "protein", - "synthetic", - "elaboration", - "complex", + "although", + "folding", + "patterning", "led", - "solution", - "structure", - "relatively", + "protein", + "study", + "autonomously", + "successfully", + "useful", "function", - "heterotetrameric", "understanding", - "computational", - "cooperatively", - "oligomer", + "stability", "known", - "combinations", - "folding", + "examples", + "solution", + "oligomer", + "interaction", + "use", + "described", + "far", + "reported", + "reveals", + "peptides", "mixed", - "possible", - "homotetramer", - "structural", - "important", - "miniproteins", - "interaction" + "heterospecificity", + "encode", + "crystal", + "screening", + "heterotetrameric", + "computational", + "advancing", + "elaboration", + "smallest" ], "release_date":"2005-02-01", "publication":"\"Design of a Heterospecific, Tetrameric, 21-Residue Miniprotein with Mixed alpha\/beta Structure\", Structure, 13, 225-234", @@ -14509,70 +14519,70 @@ ], "subtitle":"Structural studies of designed alpha-helical hairpins", "tags":[ - "helical hairpin", - "turns", "diiron proteins", "de novo protein", + "turns", + "helical hairpin", "protein design" ], "keywords":[ + "designed", + "conformation", "analysis", - "interhelical", - "longer", - "excellent", - "strands", - "proteins", - "helices", - "reached", - "although", - "class", - "chosen", + "antiparallel", + "diiron", + "hairpins", + "design", "linker", - "crystallography", - "less", - "designed", - "advanced", - "inserted", - "became", - "agreement", - "optimal", - "two", + "structural", + "context", + "loop", "dimeric", - "diiron", - "antiparallel", - "connect", - "state", - "bundle", - "stabilize", + "structures", + "agreement", + "conducted", + "concerning", "based", - "design", "apparent", - "introduced", + "preferences", + "structure", + "within", + "df1", + "although", + "chosen", "model", - "helical", - "structures", - "protein", "occur", - "conformation", - "df1", - "context", - "connects", + "crystallography", + "state", + "protein", "nmr", - "structure", - "showed", - "sequence", + "known", + "became", + "class", + "helical", + "proteins", "turns", - "concerning", - "hairpins", - "conducted", + "showed", + "strands", + "connect", + "much", "types", - "within", + "sequence", + "connects", + "inserted", + "excellent", + "reached", "turn", - "known", - "preferences", - "much", - "structural", - "loop" + "two", + "helices", + "stabilize", + "introduced", + "optimal", + "less", + "longer", + "bundle", + "interhelical", + "advanced" ], "release_date":"2005-03-22", "publication":"\"Analysis and design of turns in alpha-helical hairpins\", J.Mol.Biol., 346, 1441-1454", @@ -14680,76 +14690,76 @@ ], "subtitle":"Cc45, an artificial ww domain designed using statistical coupling analysis", "tags":[ + "computational design", "unknown function", - "artificial protein", - "computational design" + "artificial protein" ], "keywords":[ - "classical", - "statistical", - "domain", - "excellent", + "tertiary", + "shows", + "sequences", + "energy", "many", "one", - "studies", - "proteins", - "amino", - "testing", - "multiple", - "similar", - "contained", + "reduction", + "atomic", + "classical", + "show", "resolution", - "acid", + "attempt", "experimental", - "artificial", - "fold", - "thermodynamic", - "sufficient", - "define", + "structures", + "simplicity", + "natural", + "simple", "information", + "multiple", + "computationally", + "testing", "determination", + "ww", + "domain", + "define", + "agreement", + "used", + "capturing", "specify", - "alignment", - "stabilities", + "relative", "residues", - "used", - "suggests", - "simple", - "necessary", - "agreement", - "problem", - "creating", + "structure", "potential", - "domains", - "ww", - "show", - "sequences", - "structures", - "protein", - "using", - "reduction", - "required", - "attempt", - "natural", + "acid", + "fold", "complexity", - "atomic", - "tertiary", - "structure", - "sequence", + "protein", + "necessary", + "contained", + "amino", "function", + "proteins", + "artificial", + "coevolution", + "thermodynamic", + "suggests", + "domains", "native", - "specifying", - "encoded", - "computationally", - "energy", + "sequence", "marked", - "shows", - "simplicity", - "capturing", + "stabilities", + "excellent", + "sufficient", + "libraries", + "studies", + "problem", + "specifying", "rules", - "relative", - "coevolution", - "libraries" + "alignment", + "using", + "required", + "similar", + "encoded", + "creating", + "statistical" ], "release_date":"2005-09-27", "publication":"\"Evolutionary information for specifying a protein fold\", Nature, 437, 512-518", @@ -14849,77 +14859,77 @@ ], "subtitle":"Gcn4-leucine zipper core mutant asn16gln in the trimeric state", "tags":[ - "activator", + "coiled coil", "transcription regulation", - "leucine zipper", + "activator", "dna-binding", - "coiled coil", - "amino-acid biosynthesis", - "nuclear protein" + "nuclear protein", + "leucine zipper", + "amino-acid biosynthesis" ], "keywords":[ - "demonstrate", - "confer", - "chain", - "despite", - "results", - "lys", + "leucine", + "trimer", + "form", + "dimers", "surrounding", - "specificity", - "depends", - "chemical", + "lys", "complementarity", - "also", - "oligomerization", - "contrast", - "trimer", "characterized", + "asparagine", "conserved", - "peptide", - "test", - "trimers", - "atoms", - "stereochemistry", - "mutant", - "interface", - "residues", - "different", - "substitutions", - "dimer", - "burial", - "dimeric", - "selectivity", - "parallel", - "gcn4", - "leucine", - "16lys", - "dimers", + "specificity", + "asn", + "structural", + "formed", + "exclusively", + "chain", "favours", - "crystal", - "polar", "accommodated", - "exclusively", "structures", - "interactions", + "dimer", + "allowed", + "side", + "substitutions", + "different", + "environment", + "16", + "residues", + "structure", + "atoms", + "16lys", + "results", + "polar", + "gln", + "trimers", + "also", "findings", + "interactions", + "qualitatively", "buried", - "asparagine", - "similarity", + "oligomerization", + "burial", + "selectivity", + "stereochemistry", + "gcn4", + "contrast", + "demonstrate", + "test", + "parallel", "selectively", - "gln", - "structure", + "interface", + "depends", "zipper", - "allowed", - "environment", - "asn", - "16", + "confer", + "despite", + "chemical", + "crystal", + "mutant", "effects", - "form", - "side", - "qualitatively", - "structural", - "formed", - "like" + "similarity", + "like", + "peptide", + "dimeric" ], "release_date":"1997-07-07", "publication":"\"Buried polar residues and structural specificity in the GCN4 leucine zipper\", Nat.Struct.Biol., 3, 1011-1018", @@ -15025,59 +15035,59 @@ "three-helix bundle" ], "keywords":[ + "designed", + "complex", "spectroscopic", - "diverse", - "loop", - "reported", - "chains", - "proteins", - "thus", - "unique", "defined", - "common", + "design", + "miniproteins", + "shows", + "hydrophobic", + "loop", + "diverse", + "predictable", + "structures", "de", - "novo", - "although", - "thermodynamic", - "alpha3d", - "including", - "electrostatics", - "designed", - "properties", "well", + "natural", "yet", - "determined", - "set", - "bundle", - "implications", + "possible", + "side", "based", - "design", - "features", - "incorporates", - "structures", - "protein", - "typical", - "complex", + "contribute", + "thus", + "properties", + "electrostatics", + "important", + "structure", + "determined", + "although", "endeavor", - "hydrophobic", + "folding", "nmr", - "natural", - "variety", - "solution", - "structure", + "alpha3d", + "protein", + "typical", "capping", - "predictable", - "native", - "motifs", "understanding", - "shows", - "side", - "folding", - "contribute", + "proteins", "packing", - "possible", - "important", - "miniproteins" + "solution", + "incorporates", + "thermodynamic", + "novo", + "native", + "reported", + "common", + "motifs", + "implications", + "variety", + "unique", + "features", + "chains", + "bundle", + "including", + "set" ], "release_date":"1999-05-05", "publication":"\"Solution structure and dynamics of a de novo designed three-helix bundle protein\", Proc.Natl.Acad.Sci.USA, 96, 5486-5491", @@ -15181,80 +15191,80 @@ ], "subtitle":"Crystal structure of an 8 repeat consensus tpr superhelix", "tags":[ - "superhelix", "consensus protein", - "tpr", + "superhelix", "de novo protein", + "tpr", "tetratricopeptide repeat" ], "keywords":[ - "predicted", - "stability", - "series", - "analysis", - "overall", - "excellent", - "eight", - "perhaps", - "tprs", - "proteins", - "studied", - "forms", - "unique", - "also", - "presented", - "familiar", - "described", - "globular", - "thermodynamic", - "ctpr", "designed", + "repeats", + "superhelical", + "crystalline", + "ising", "finally", - "tandem", - "stabilities", - "resulting", - "different", - "little", - "shown", - "motif", - "repertoire", + "analysis", "behavior", - "crystal", - "covers", - "system", - "domains", - "observed", - "comparison", "design", - "previously", - "model", + "adopt", + "compared", + "repeat", + "tprs", + "ctpr", "tpr", + "observed", "structures", - "superhelical", + "natural", + "previously", + "different", + "overall", + "properties", + "structure", + "studied", + "resulting", + "also", + "occurs", + "model", "interactions", - "using", - "adopt", "protein", - "adopts", - "identical", "superhelices", - "natural", - "structure", - "unusual", - "repeat", - "repeats", - "size", - "ising", - "crystalline", + "globular", + "shown", + "stability", "20", - "compared", - "ctpr20", + "proteins", + "little", + "eight", + "motif", + "familiar", + "size", + "thermodynamic", + "described", + "tandem", + "consensus", + "presented", "discussed", - "occurs", + "domains", + "adopts", + "series", + "predicted", + "perhaps", + "system", + "repertoire", "ctpr8", - "consensus", + "forms", + "covers", "contain", - "properties" + "identical", + "excellent", + "crystal", + "using", + "unique", + "unusual", + "ctpr20", + "comparison", + "stabilities" ], "release_date":"2005-09-13", "publication":"\"Structure and stability of designed TPR protein superhelices: unusual crystal packing and implications for natural TPR proteins\", Acta Crystallogr.,Sect.D, 63, 800-811", @@ -15413,78 +15423,78 @@ ], "subtitle":"Crystal structure of e3_19 a designed ankyrin repeat protein", "tags":[ - "ankyrin repeat", "de novo protein", - "designed protein", + "protein stability", "consensus design", - "protein stability" + "designed protein", + "ankyrin repeat" ], "keywords":[ - "stability", + "coordinates", + "designed", + "surface", "pdb", - "domain", "analysis", - "data", - "despite", - "deposited", - "proteins", + "rmsd", "identity", - "exhibits", - "coordinates", - "difference", - "patterns", - "stable", - "resolution", + "revealed", + "however", "conserved", - "correlations", - "2bkg", - "fold", + "structural", "calpha", - "designed", - "charge", + "thermodynamically", + "resolution", + "repeat", + "exposed", + "hydrophobic", + "atomic", + "observed", + "deposited", + "correlations", "well", - "clusters", - "ankyrin", - "appear", - "highly", - "distribution", - "residues", - "two", "due", - "exposed", + "distribution", + "virtually", + "domain", + "differences", + "clusters", + "id", "approximately", - "crystal", + "ar", + "structure", + "residues", + "fold", + "appear", "determined", - "id", - "clear", - "88", - "features", - "observed", - "bank", + "charge", + "characteristic", + "exhibits", "protein", + "patterns", + "2bkg", + "stability", + "significantly", + "proteins", + "clear", "regular", - "identical", - "hydrophobic", + "molecules", + "ankyrin", + "networks", "charged", - "surface", - "differences", - "ar", - "structure", + "difference", + "highly", "sequence", - "repeat", - "revealed", - "atomic", "motifs", - "thermodynamically", - "networks", - "significantly", - "virtually", - "however", - "molecules", - "structural", - "characteristic", + "identical", + "bank", + "two", + "despite", + "data", + "crystal", + "stable", + "features", + "88", "lower", - "rmsd", "investigate" ], "release_date":"2006-06-21", @@ -15518,11 +15528,11 @@ "seq_thr_sim_designed":[ { "sim":293.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":293.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":290.0, @@ -15538,7 +15548,7 @@ }, { "sim":288.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":288.0, @@ -15546,15 +15556,15 @@ }, { "sim":288.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":288.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":288.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":288.0, @@ -15562,15 +15572,15 @@ }, { "sim":288.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":288.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":288.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":288.0, @@ -15578,31 +15588,31 @@ }, { "sim":288.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":288.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":288.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":288.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":288.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":282.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":282.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":278.0, @@ -15722,7 +15732,7 @@ }, { "sim":248.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":248.0, @@ -15730,7 +15740,7 @@ }, { "sim":248.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":246.0, @@ -15790,11 +15800,11 @@ }, { "sim":211.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":211.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":211.0, @@ -15826,11 +15836,11 @@ }, { "sim":193.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":193.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":189.0, @@ -15840,6 +15850,10 @@ "sim":186.0, "partner":"8rci" }, + { + "sim":183.0, + "partner":"9glq" + }, { "sim":183.0, "partner":"4hqd" @@ -15976,15 +15990,15 @@ }, { "sim":69.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":69.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":69.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":62.0, @@ -16001,6 +16015,10 @@ { "sim":57.0, "partner":"1ycs" + }, + { + "sim":55.0, + "partner":"8ycp" } ], "struct_thr_sim_designed":[ @@ -16198,7 +16216,7 @@ ], "seq_max_sim_designed":{ "sim":293.0, - "partner":"5oou" + "partner":"5op3" }, "seq_max_sim_natural":{ "sim":284.0, @@ -16260,85 +16278,85 @@ ], "subtitle":"Solution structure of the de novo-designed lambda cro fold protein", "tags":[ - "lambda cro fold", - "de novo protein" + "de novo protein", + "lambda cro fold" ], "keywords":[ - "classical", - "compatibility", - "variant", - "prevent", - "monomeric", - "one", + "tertiary", + "designed", + "stably", "biochemically", - "amino", - "proteins", "identity", - "solved", - "thus", - "redesigned", - "unique", - "lambda", - "similar", - "25", - "wide", "characterized", - "acid", - "artificial", - "fold", - "stably", - "designed", + "sequences", + "one", + "redesigned", + "backbones", + "concentrations", + "classical", "spectroscopy", + "structures", + "lambda", "well", - "deviation", - "finding", - "residues", - "useful", - "functions", - "phe58", - "dimer", + "natural", "annealing", - "region", - "provide", + "synthesized", + "computationally", + "dimer", + "core", "simulated", + "preserves", + "prevent", + "thus", + "deviation", + "residues", + "structure", + "important", + "fold", + "acid", + "monomeric", + "variant", "determined", - "folded", - "target", - "bacteriophage", - "stabilize", - "60", - "relationships", "polypeptide", - "core", - "sequences", - "approximate", - "protein", - "synthesized", - "using", - "structures", - "given", - "backbone", - "natural", + "provide", + "finding", "insertion", + "functions", + "target", "nmr", - "solution", - "tertiary", - "structure", - "sequence", - "essential", - "foldable", - "homodimer", - "computationally", - "cro", + "protein", + "relationships", + "folded", + "useful", + "amino", + "25", + "wide", + "given", + "proteins", + "dimerization", + "solution", + "artificial", "formation", - "important", - "backbones", - "novel", - "preserves", + "approximate", + "essential", + "backbone", + "sequence", + "compatibility", + "solved", + "homodimer", "forms", - "concentrations", - "dimerization", - "range" + "60", + "cro", + "phe58", + "region", + "unique", + "stabilize", + "range", + "foldable", + "bacteriophage", + "using", + "similar", + "novel" ], "release_date":"2005-12-13", "publication":"\"Design of lambda Cro fold: solution structure of a monomeric variant of the de novo protein\", J.Mol.Biol., 354, 801-814", @@ -16450,107 +16468,107 @@ ], "subtitle":"Solution structure of hp7, a 12-residue beta hairpin", "tags":[ - "de novo protein", "beta hairpin", + "de novo protein", "trp\/trp packing" ], "keywords":[ + "hairpins", + "additional", + "trp", + "measures", + "provided", + "short", + "residue", + "folding", + "parameters", + "cd", + "hepsilon3", + "deltac", + "x", + "representative", + "motif", "unfolding", - "established", - "j", + "thermodynamic", + "ktwnpatgkwte", + "site", + "stacking", + "motifs", + "two", + "k", "temperatures", - "upfield", - "cd", - "retained", - "mutations", - "mutation", - "enthalpically", + "imparts", "geometric", - "sequences", - "comparisons", - "interactions", - "8", - "representative", + "kkwtwnpatgkwtwqe", "indicators", - "turn", - "measures", - "interaction", - "k", + "p", + "respectively", + "due", + "upfield", + "residues", "reflect", - "ktwnpatgkwte", - "shifted", - "6", - "small", - "short", - "motif", - "destabilizing", - "structures", - "construct", - "motifs", - "form", - "additional", - "gly", - "magnitude", - "preferences", - "alanine", - "provided", + "case", "stability", - "data", - "u", - "278", - "loops", + "destabilizing", + "packing", + "2", + "established", "couplet", - "respectively", + "small", + "nearest", "chemical", - "common", - "geometry", - "ppm", - "imparts", - "class", - "thermodynamic", - "exciton", + "construct", "1", + "ppm", + "lys", + "beta", + "loops", + "shifts", + "preferences", + "fold", + "alanine", + "driven", + "also", "asx", "reduced", + "interaction", + "comparisons", + "retained", + "common", + "magnitude", + "peptides", + "laboratory", + "gly", + "mutation", + "reveal", + "form", "melts", - "nmr", - "parameters", - "etf", + "enthalpically", + "sequences", "indicate", - "trp", - "packing", + "6", + "u", + "geometry", + "mutations", + "structures", + "exciton", + "structuring", + "hairpin", "important", - "laboratory", + "nmr", + "interactions", + "minimized", "deltag", - "lys", - "structuring", - "also", - "driven", + "shifted", + "class", "298", - "hepsilon3", - "fold", - "peptides", - "stacking", - "residues", - "reveal", - "kkwtwnpatgkwtwqe", - "minimized", - "two", - "due", - "nearest", - "significant", - "residue", - "2", - "shifts", - "hairpins", - "beta", - "hairpin", - "x", - "deltac", - "case", - "folding", - "p", - "site" + "j", + "turn", + "data", + "278", + "etf", + "8", + "significant" ], "release_date":"2006-03-07", "publication":"\"Minimization and Optimization of Designed beta-Hairpin Folds\", J.Am.Chem.Soc., 128, 6101-6110", @@ -16650,80 +16668,80 @@ ], "subtitle":"Crystal structure of an 8 repeat consensus tpr superhelix (trigonal crystal form)", "tags":[ - "superhelix", "consensus protein", - "tpr", + "superhelix", "de novo protein", + "tpr", "tetratricopeptide repeat" ], "keywords":[ - "predicted", - "stability", - "series", - "analysis", - "overall", - "excellent", - "eight", - "perhaps", - "tprs", - "proteins", - "studied", - "forms", - "unique", - "also", - "presented", - "familiar", - "described", - "globular", - "thermodynamic", - "ctpr", "designed", + "repeats", + "superhelical", + "crystalline", + "ising", "finally", - "tandem", - "stabilities", - "resulting", - "different", - "little", - "shown", - "motif", - "repertoire", + "analysis", "behavior", - "crystal", - "covers", - "system", - "domains", - "observed", - "comparison", "design", - "previously", - "model", + "adopt", + "compared", + "repeat", + "tprs", + "ctpr", "tpr", + "observed", "structures", - "superhelical", + "natural", + "previously", + "different", + "overall", + "properties", + "structure", + "studied", + "resulting", + "also", + "occurs", + "model", "interactions", - "using", - "adopt", "protein", - "adopts", - "identical", "superhelices", - "natural", - "structure", - "unusual", - "repeat", - "repeats", - "size", - "ising", - "crystalline", + "globular", + "shown", + "stability", "20", - "compared", - "ctpr20", + "proteins", + "little", + "eight", + "motif", + "familiar", + "size", + "thermodynamic", + "described", + "tandem", + "consensus", + "presented", "discussed", - "occurs", + "domains", + "adopts", + "series", + "predicted", + "perhaps", + "system", + "repertoire", "ctpr8", - "consensus", + "forms", + "covers", "contain", - "properties" + "identical", + "excellent", + "crystal", + "using", + "unique", + "unusual", + "ctpr20", + "comparison", + "stabilities" ], "release_date":"2006-03-07", "publication":"\"Structure and stability of designed TPR protein superhelices: unusual crystal packing and implications for natural TPR proteins\", Acta Crystallogr.,Sect.D, 63, 800-811", @@ -16903,113 +16921,113 @@ "obligate symmetric homo-dimer" ], "keywords":[ - "evolution", - "49", - "genetic", - "scattering", - "selection", - "independently", + "escherichia", + "rate", + "stringent", + "show", + "machinery", + "translation", + "within", + "protein", + "globular", + "accumulation", + "significantly", + "binding", + "cellular", + "parallels", + "rare", "top7", + "circular", + "expected", + "two", + "stable", + "corresponding", + "independently", + "engineered", + "observation", + "ribosome", + "final", + "accumulates", + "residues", + "functions", + "occur", "extremely", - "show", - "based", + "proteins", + "sites", + "scattering", + "modular", + "analytical", + "adopts", + "circularisation", + "found", + "created", + "aspects", + "evolution", + "since", + "compact", + "computational", "regions", + "investigate", + "design", + "selection", + "spectroscopy", + "provides", + "used", + "even", + "natural", + "absence", + "platform", + "fold", + "variant", "subject", - "exposes", - "opportunity", + "covalent", "chromatography", - "structure", - "escherichia", - "accumulates", - "recently", - "pressure", - "recombination", - "novel", - "even", + "symmetric", + "solution", + "coli", + "49", + "sequence", + "levels", "excellent", - "proteins", - "random", "cfr", - "less", - "resulting", - "used", - "nature", - "symmetric", + "identical", + "recombination", + "mechanism", + "implies", + "production", + "surveillance", "evolutionary", "often", - "production", - "structures", - "portion", - "natural", - "corresponding", - "solution", - "parallels", - "cellular", - "circular", - "significantly", "coupled", - "implies", - "platform", - "created", - "previously", - "investigate", - "analytical", - "covalent", - "accumulation", - "quality", - "expected", - "stringent", - "coli", - "generate", - "globular", - "since", - "fragments", - "functions", - "translation", - "rate", - "provides", + "portion", "observed", - "design", - "error", - "occur", + "chance", + "fragments", + "structures", + "exposes", + "previously", + "based", + "efficiently", + "structure", + "resulting", + "fragment", + "recently", "nmr", + "nature", + "random", "high", - "sequence", - "observation", - "compact", - "variant", - "sites", - "rare", - "final", - "efficiently", - "surveillance", - "circularisation", - "chance", - "aspects", + "dichroism", + "genetic", + "error", + "pressure", "rarity", - "stable", - "ribosome", - "fold", - "spectroscopy", - "modular", - "engineered", - "residues", - "found", - "fragment", - "absence", + "quality", + "create", "correspondingly", - "two", - "mechanism", - "protein", - "levels", - "adopts", - "identical", - "within", - "computational", - "machinery", - "dichroism", - "binding", - "create" + "less", + "opportunity", + "generate", + "novel" ], "release_date":"2006-10-17", "publication":"\"Mis-translation of a Computationally Designed Protein Yields an Exceptionally Stable Homodimer: Implications for Protein Engineering and Evolution\", J.Mol.Biol., 362, 1004-1024", @@ -17110,81 +17128,81 @@ ], "subtitle":"Crystal structure of an 8 repeat consensus tpr superhelix (orthorombic crystal form)", "tags":[ - "tetratricopeptide", "superhelix", - "tpr", + "protein stability", "de novo protein", - "protein design", - "protein stability" + "tetratricopeptide", + "tpr", + "protein design" ], "keywords":[ - "predicted", - "stability", - "series", - "analysis", - "overall", - "excellent", - "eight", - "perhaps", - "tprs", - "proteins", - "studied", - "forms", - "unique", - "also", - "presented", - "familiar", - "described", - "globular", - "thermodynamic", - "ctpr", "designed", + "repeats", + "superhelical", + "crystalline", + "ising", "finally", - "tandem", - "stabilities", - "resulting", - "different", - "little", - "shown", - "motif", - "repertoire", + "analysis", "behavior", - "crystal", - "covers", - "system", - "domains", - "observed", - "comparison", "design", - "previously", - "model", + "adopt", + "compared", + "repeat", + "tprs", + "ctpr", "tpr", + "observed", "structures", - "superhelical", + "natural", + "previously", + "different", + "overall", + "properties", + "structure", + "studied", + "resulting", + "also", + "occurs", + "model", "interactions", - "using", - "adopt", "protein", - "adopts", - "identical", "superhelices", - "natural", - "structure", - "unusual", - "repeat", - "repeats", - "size", - "ising", - "crystalline", + "globular", + "shown", + "stability", "20", - "compared", - "ctpr20", + "proteins", + "little", + "eight", + "motif", + "familiar", + "size", + "thermodynamic", + "described", + "tandem", + "consensus", + "presented", "discussed", - "occurs", + "domains", + "adopts", + "series", + "predicted", + "perhaps", + "system", + "repertoire", "ctpr8", - "consensus", + "forms", + "covers", "contain", - "properties" + "identical", + "excellent", + "crystal", + "using", + "unique", + "unusual", + "ctpr20", + "comparison", + "stabilities" ], "release_date":"2008-02-19", "publication":"\"Structure and stability of designed TPR protein superhelices: unusual crystal packing and implications for natural TPR proteins\", Acta Crystallogr.,Sect.D, 63, 800-811", @@ -17348,124 +17366,124 @@ "subtitle":"A designed ankyrin repeat protein evolved to picomolar affinity to her2", "tags":[ "human epidermal growth factor receptor 2", - "membrane protein", - "de novo protein", "ankyrin repeat protein", "darpin", + "de novo protein", + "membrane protein", "her2" ], "keywords":[ - "analysis", - "causes", - "pm", - "change", - "low", + "affinity", + "relatively", + "structural", + "repeat", + "alters", "pattern", - "selection", - "increasing", - "acid", - "occurred", - "designed", - "receptor", - "sensitive", - "thought", - "pcr", "substitutions", - "mutations", - "mutation", - "crystal", - "determined", - "target", + "via", + "unusually", + "acid", + "framework", + "residue", "zero", - "position", - "enhanced", - "typical", - "reason", + "positions", + "binding", + "changes", + "yielding", + "rare", "her2", - "structure", - "display", - "repeat", - "carried", - "clones", - "affinity", - "coming", - "novel", - "average", - "seven", - "suggesting", - "detecting", - "proteins", + "location", + "thought", + "extracts", + "variety", + "crystal", + "mutated", "growth", - "specifically", - "52", - "yielding", - "highly", - "suggests", - "epidermal", - "nanomolar", - "positions", - "future", - "tyr", + "bearing", + "receptor", "either", - "compared", - "molecules", - "unusually", - "consensus", - "previously", - "framework", + "ribosome", + "subdomains", + "conformational", + "highest", "randomization", - "amino", - "via", + "clones", + "selected", + "relative", + "residues", + "causes", + "library", + "maturation", + "tyr", + "proteins", + "low", + "factor", "disposition", - "changes", - "class", + "ankyrin", + "2", + "consensus", + "highly", + "found", + "coming", + "suggesting", + "future", "four", - "darpins", + "nanomolar", + "carried", + "carcinoma", + "values", + "increase", + "slow", "mainly", + "enhanced", "design", - "alters", - "recognize", - "his52tyr", - "describe", - "stabilized", - "increase", - "could", - "subdomains", - "structural", - "selected", + "pm", + "compared", + "detecting", + "selection", + "reason", + "suggests", + "display", "variant", - "library", - "factor", - "rare", - "values", - "conformational", + "pcr", + "amino", "wide", - "highest", - "ribosome", + "leading", "90", - "human", - "carcinoma", - "extracts", - "ankyrin", - "residues", + "describe", + "his52tyr", + "spectrum", + "increasing", + "darpins", + "mutation", + "52", + "could", + "designed", + "analysis", + "average", + "epidermal", + "mutations", + "previously", "darpin", - "affinities", - "found", - "leading", + "specifically", + "structure", + "determined", + "recognize", + "target", "state", - "significant", - "residue", - "mutated", - "2", - "variety", - "relatively", - "maturation", - "spectrum", - "bearing", - "location", - "relative", - "binding", - "slow" + "typical", + "class", + "molecules", + "change", + "seven", + "position", + "human", + "affinities", + "occurred", + "stabilized", + "sensitive", + "novel", + "significant" ], "release_date":"2007-05-08", "publication":"\"A Designed Ankyrin Repeat Protein Evolved to Picomolar Affinity to Her2\", J.Mol.Biol., 369, 1015", @@ -17498,19 +17516,19 @@ "seq_thr_sim_designed":[ { "sim":227.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":227.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":227.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":227.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":227.0, @@ -17518,35 +17536,35 @@ }, { "sim":227.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":227.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":227.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":227.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":227.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":227.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":227.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":227.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":226.0, @@ -17622,11 +17640,11 @@ }, { "sim":204.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":204.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":203.0, @@ -17698,7 +17716,7 @@ }, { "sim":190.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":190.0, @@ -17706,7 +17724,7 @@ }, { "sim":190.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":189.0, @@ -17744,6 +17762,10 @@ "sim":186.0, "partner":"7dne" }, + { + "sim":185.0, + "partner":"9glq" + }, { "sim":185.0, "partner":"7z7c" @@ -17794,11 +17816,11 @@ }, { "sim":164.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":164.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":164.0, @@ -17818,11 +17840,11 @@ }, { "sim":145.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":145.0, - "partner":"4qfv" + "partner":"4o60" }, { "sim":142.0, @@ -17842,15 +17864,15 @@ }, { "sim":124.0, - "partner":"4gpm" + "partner":"5hry" }, { "sim":124.0, - "partner":"5hry" + "partner":"4hb5" }, { "sim":124.0, - "partner":"4hb5" + "partner":"4gpm" }, { "sim":118.0, @@ -17968,15 +17990,15 @@ }, { "sim":63.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":63.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":63.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":61.0, @@ -17996,11 +18018,11 @@ }, { "sim":57.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":57.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":57.0, @@ -18015,7 +18037,7 @@ ], "seq_max_sim_designed":{ "sim":227.0, - "partner":"8qla" + "partner":"8ql3" }, "seq_max_sim_natural":{ "sim":219.0, @@ -18073,88 +18095,88 @@ ], "subtitle":"Structure of the arsenated de novo designed peptide coil ser l9c", "tags":[ - "arsenic(iii) binding protein", "de novo protein", - "three-stranded coiled coil", - "de novo design" + "de novo design", + "arsenic(iii) binding protein", + "three-stranded coiled coil" ], "keywords":[ - "impact", - "contaminant", - "without", + "relatively", + "designed", + "complex", "dissociates", - "reported", + "configuration", "toxic", - "despite", - "cysteine", - "one", - "change", + "contaminant", + "escherichia", + "operon", "critical", - "detail", - "proteins", - "ars", - "arsd", - "providing", "conformational", - "dna", - "coli", - "inorganic", - "report", - "de", - "novo", + "one", + "structural", "resolution", - "ions", - "allowing", + "tris", + "providing", + "arsenated", + "structures", + "de", + "arsr", + "ser", "understand", + "health", "regulated", - "designed", - "peptides", - "arsenic", + "environment", + "dna", + "three", + "thiolate", + "unfortunately", "residues", + "without", + "consistent", + "within", + "structure", + "report", + "cysteine", "l9c", - "proposed", - "iii", - "configuration", - "endo", - "little", - "binds", - "bacteria", - "characterization", - "unfortunately", - "repressor", - "structures", "interactions", + "impact", "protein", - "using", - "upon", - "resistance", - "arsr", "bind", - "complex", - "tris", - "ser", - "water", - "relatively", - "three", - "structure", - "alternatively", - "escherichia", - "operon", - "environment", - "thiolate", - "health", - "evolved", - "within", - "coil", "basis", - "arsenated", - "undergoes", "known", - "worldwide", - "consistent", + "resistance", + "proteins", "binding", - "structural", - "supplies" + "little", + "detail", + "inorganic", + "worldwide", + "arsenic", + "ions", + "characterization", + "change", + "coli", + "undergoes", + "ars", + "iii", + "upon", + "alternatively", + "novo", + "reported", + "coil", + "allowing", + "peptides", + "despite", + "endo", + "arsd", + "binds", + "supplies", + "repressor", + "evolved", + "proposed", + "using", + "bacteria", + "water" ], "release_date":"2007-07-10", "publication":"\"Identifying Important Structural Characteristics of Arsenic Resistance Proteins by Using Designed Three-Stranded Coiled Coils\", Proc.Natl.Acad.Sci.USA, 104, 11969", @@ -18191,19 +18213,19 @@ }, { "sim":51.0, - "partner":"5u9u" + "partner":"3pbj" }, { "sim":51.0, - "partner":"5k92" + "partner":"5u9t" }, { "sim":51.0, - "partner":"3pbj" + "partner":"5k92" }, { "sim":51.0, - "partner":"5u9t" + "partner":"5u9u" } ], "seq_thr_sim_natural":[ @@ -18222,14 +18244,14 @@ "sim":1.0, "partner":"5u9t" }, - { - "sim":0.9879000187, - "partner":"1cos" - }, { "sim":0.9983999729, "partner":"5u9u" }, + { + "sim":0.9879000187, + "partner":"1cos" + }, { "sim":0.961499989, "partner":"3h5f" @@ -18254,6 +18276,10 @@ "sim":0.9970999956, "partner":"6q1w" }, + { + "sim":0.9911000133, + "partner":"6u47" + }, { "sim":0.9970999956, "partner":"6v5g" @@ -18266,6 +18292,10 @@ "sim":0.9970999956, "partner":"6v5j" }, + { + "sim":0.9940999746, + "partner":"6v4y" + }, { "sim":0.9900000095, "partner":"6v50" @@ -18275,29 +18305,17 @@ "partner":"6ovs" }, { - "sim":0.9911000133, - "partner":"6u47" + "sim":0.9901999831, + "partner":"6q25" }, { "sim":0.992299974, "partner":"6v58" }, - { - "sim":0.9940999746, - "partner":"6v4y" - }, - { - "sim":0.9901999831, - "partner":"6q25" - }, { "sim":0.9510999918, "partner":"6ovu" }, - { - "sim":0.9527999759, - "partner":"6ov9" - }, { "sim":0.9599000216, "partner":"1coi" @@ -18306,26 +18324,26 @@ "sim":0.9559999704, "partner":"6q5r" }, - { - "sim":0.9937999845, - "partner":"5vte" - }, { "sim":0.9542999864, "partner":"6q5s" }, { - "sim":0.9618999958, - "partner":"1fmh" + "sim":0.9937999845, + "partner":"5vte" }, { - "sim":0.951300025, - "partner":"6q5q" + "sim":0.9618999958, + "partner":"1fmh" }, { "sim":0.9542000294, "partner":"5kb0" }, + { + "sim":0.9527999759, + "partner":"6ov9" + }, { "sim":0.9527999759, "partner":"6v57" @@ -18341,6 +18359,10 @@ { "sim":0.9524000287, "partner":"6q22" + }, + { + "sim":0.951300025, + "partner":"6q5q" } ], "struct_thr_sim_natural":[ @@ -18412,114 +18434,114 @@ ], "subtitle":"The trp-cage: optimizing the stability of a globular miniprotein", "tags":[ - "miniprotein", "de novo protein", + "trp-cage", "two-state folding", - "trp-cage" + "miniprotein" ], "keywords":[ + "p12", + "hydrophobic", + "deltadeltas", + "tm", + "experimental", + "well", + "trp", + "core", + "prolines", + "side", + "three", + "points", "results", + "pro", "bridge", - "studies", + "folding", + "degrees", + "protein", + "burial", + "significantly", + "destabilization", + "salt", + "helical", + "changes", + "stabilization", + "motif", + "measured", + "essential", + "site", + "indole", + "original", + "two", + "k", + "10", + "defines", + "initial", + "however", + "fluxionality", + "include", "stabilizing", + "identified", + "residues", + "specific", "ring", - "reduces", - "ile", - "fluxionality", - "miniprotein", - "mutations", - "prolines", + "contrary", + "buried", + "stability", + "2", + "advantage", + "nlyiqwlkdggpssgrppps", + "features", "pathways", + "leu", + "entropic", + "hypothesis", + "computational", + "ala", "11", - "portions", - "mutation", - "encage", - "features", - "p17", - "subject", - "interactions", + "smallest", "c", - "structure", - "allowed", + "lys", + "chain", "16", - "favorable", - "however", - "deltadeltas", + "approximately", + "fold", + "subject", + "reduces", + "ile", + "formation", + "staple", "interaction", - "k", - "42", - "original", - "pro", - "chain", - "less", - "leu", - "64", - "remains", - "burial", - "initial", - "motif", - "include", - "dynamics", - "measured", - "numerous", "upon", - "buried", - "advantage", - "versus", - "essential", - "three", - "significantly", - "stability", - "salt", "reported", - "replacement", - "nlyiqwlkdggpssgrppps", + "numerous", + "versus", + "mutation", + "dynamics", + "portions", + "64", "u", - "changes", - "hypothesis", - "smallest", - "p12", - "10", - "entropic", - "specific", - "unit", - "result", - "points", - "melting", - "core", - "helical", - "defines", - "hydrophobic", + "mutations", + "p17", + "p19a", "ser", + "allowed", + "remains", + "structure", + "42", + "interactions", + "reflecting", + "melting", + "unit", "high", - "stabilized", "p18", - "formation", - "trp", - "indole", - "stabilization", - "lys", - "destabilization", - "experimental", - "fold", - "well", - "residues", - "two", - "identified", - "approximately", - "ala", - "reflecting", - "staple", - "protein", - "2", - "degrees", - "contrary", - "p19a", - "computational", - "tm", - "side", - "folding", - "site" + "result", + "favorable", + "studies", + "encage", + "replacement", + "miniprotein", + "less", + "stabilized" ], "release_date":"2008-03-04", "publication":"\"The Trp-cage: optimizing the stability of a globular miniprotein\", Protein Eng.Des.Sel., 21, 171-185", @@ -18751,132 +18773,132 @@ ], "subtitle":"Four-alpha-helix bundle with designed anesthetic binding pockets ii: halothane effects on structure and dynamics", "tags":[ - "anesthetic binding", - "four-alpha-helix bundle", "homo dimer", "de novo protein", + "four-alpha-helix bundle", + "anesthetic binding", "alpha helix" ], "keywords":[ - "exchange", - "analysis", - "amphipathic", - "results", - "located", - "accessing", - "long", - "initially", - "stabilizing", - "l18", - "suggest", - "dispersion", - "including", - "anesthetic", - "designed", - "near", - "induced", - "dimeric", - "local", - "determined", - "target", - "dynamical", - "interactions", + "hydrophobic", + "structural", + "scale", + "half", + "profound", "enclosed", - "access", - "structure", - "monomer", - "turn", - "leads", - "primary", - "quaternary", - "novel", - "phase", - "a44", - "molecule", - "direct", - "proteins", - "suppression", - "shifted", - "clinically", + "core", + "dispersion", "presence", - "used", - "highly", - "quantitative", - "remote", - "dynamics", - "dynamic", - "scale", - "showed", - "revealed", - "w15", - "measurements", - "consequence", - "contribute", - "data", - "produces", - "another", - "anesthetics", - "changes", - "asymmetric", - "four", - "lateral", - "may", - "dimer", - "specific", - "universal", - "bundle", - "closure", + "deviation", + "results", + "root", "model", - "core", - "volatile", - "action", + "protein", + "study", "helical", - "rather", - "hydrophobic", + "binding", + "changes", "relaxation", - "nmr", - "effect", - "minor", - "root", + "showed", + "site", "modelfree", - "structural", - "sites", - "arrangement", - "analyses", - "pathway", + "anesthetic", + "two", + "induced", + "twists", "helices", + "global", "aqueous", + "initially", + "neuronal", + "asymmetric", + "antiparallel", + "dynamic", "conformational", - "also", - "study", - "halothane", - "half", - "deviation", - "different", + "action", + "stabilizing", + "dimer", + "access", + "effect", + "relative", "residues", + "specific", + "targets", + "quaternary", + "consequence", + "phase", "changing", - "absence", - "two", - "aalpha", - "antiparallel", - "mechanism", - "binding", - "protein", + "dynamical", + "suppression", "bound", - "neuronal", + "sites", + "produces", + "proteins", "2", - "targets", - "backbone", - "twists", + "may", + "highly", + "suggest", + "contain", "transverse", - "profound", - "fit", + "lateral", + "monomer", + "four", + "long", + "bundle", + "including", + "direct", + "measurements", + "molecule", + "local", "2jst", - "global", - "relative", - "site", - "contain", - "whereas" + "another", + "fit", + "used", + "absence", + "different", + "leads", + "also", + "w15", + "closure", + "primary", + "backbone", + "pathway", + "arrangement", + "exchange", + "near", + "whereas", + "analyses", + "mechanism", + "universal", + "amphipathic", + "clinically", + "dynamics", + "designed", + "analysis", + "aalpha", + "revealed", + "l18", + "rather", + "contribute", + "accessing", + "a44", + "structure", + "determined", + "anesthetics", + "target", + "nmr", + "interactions", + "shifted", + "volatile", + "halothane", + "quantitative", + "located", + "minor", + "turn", + "data", + "remote", + "novel", + "dimeric" ], "release_date":"2008-05-27", "publication":"\"Four-alpha-helix bundle with designed anesthetic binding pockets. Part II: halothane effects on structure and dynamics\", Biophys.J., 94, 4464-4472", @@ -18979,120 +19001,120 @@ "de novo protein" ], "keywords":[ - "exchange", - "tightness", - "containing", - "evidence", - "reinforces", - "studies", - "probed", - "strategy", - "selection", - "biased", - "patterning", - "stabilities", - "provide", - "potential", - "show", - "sampling", - "sequences", - "regions", + "individual", + "proved", + "hydrophobic", + "structural", "probe", - "packed", + "show", + "modulated", + "coincide", + "core", + "side", + "differences", + "patterned", + "within", "assess", - "similarity", - "opportunity", - "structure", - "hydrophilic", - "however", - "consistent", + "strategy", + "folding", + "degrees", + "drive", + "protein", + "given", + "fully", + "showed", + "novo", + "modelfree", + "two", + "stable", + "global", + "chains", + "similarities", + "using", + "previous", + "stabilities", "binary", - "without", - "topology", + "billions", + "bundles", + "however", + "biased", + "enormity", + "biological", + "residues", + "hydrophilic", + "library", + "folded", + "approach", + "account", "proteins", - "solved", - "investigated", - "random", - "de", - "similarities", + "packing", + "evidence", + "2", + "probed", + "chemical", + "higher", + "bundle", + "regions", + "1", + "identity", + "design", + "sampling", + "topology", + "packed", + "selection", + "functional", + "different", + "potential", + "explore", + "amino", + "shown", "superfamily", + "reinforces", + "frequency", + "sequence", + "solved", + "exchange", + "relationship", + "encode", "stochastic", - "less", - "fully", - "evolutionary", - "folded", - "billions", - "drive", "dynamics", - "individual", - "structures", - "proved", - "showed", + "evolutionary", + "explicit", "particular", - "likely", - "second", - "molecules", + "sequences", + "space", + "investigated", + "one", + "structures", + "de", + "rational", "previously", - "fraction", - "quality", - "years", - "functional", - "amino", - "identity", - "higher", - "chemical", - "bundles", + "tightness", + "likely", + "without", + "structure", "report", - "1", - "acids", - "shown", - "bundle", - "design", - "encode", - "core", - "enormity", - "modulated", - "using", - "account", - "hydrophobic", + "provide", + "patterning", "nmr", + "yield", + "random", + "molecules", "high", - "explicit", - "sequence", - "coincide", - "biological", - "modelfree", - "packing", - "structural", - "library", - "patterned", - "despite", - "chains", - "one", - "approach", - "novo", - "stable", - "rational", - "different", - "residues", - "two", - "frequency", - "explore", + "years", + "fraction", + "acids", "cores", - "protein", - "yield", - "given", - "2", - "previous", - "degrees", - "space", - "differences", - "relationship", - "within", - "side", - "global", - "folding", - "libraries" + "libraries", + "despite", + "studies", + "quality", + "second", + "similarity", + "containing", + "less", + "opportunity", + "consistent" ], "release_date":"2008-05-20", "publication":"\"Structure and dynamics of de novo proteins from a designed superfamily of 4-helix bundles\", Protein Sci., 17, 821-832", @@ -19204,9 +19226,9 @@ ], "subtitle":"Solution structure of m7, a computationally-designed artificial protein", "tags":[ - "artificial fold", "de novo protein", - "tetrapeptide fragment-based protein design" + "tetrapeptide fragment-based protein design", + "artificial fold" ], "keywords":[ "description", @@ -19314,114 +19336,114 @@ ], "subtitle":"Solution nmr structures of two designed proteins with 88% sequence identity but different fold and function", "tags":[ + "evolution", "de novo protein", - "folding", "protein design", - "evolution" + "folding" ], "keywords":[ - "evolution", - "alexander", - "monomeric", - "thus", - "must", - "taking", - "determination", - "designed", - "geometries", - "mutations", - "provide", - "mutation", - "determined", "acad", - "basis", - "therefore", - "structure", + "prevails", "insights", - "16", - "recently", - "leads", + "structural", + "number", + "therefore", + "question", + "56", + "new", + "folding", + "sci", + "protein", + "pair", + "guided", + "b", + "two", + "total", + "g", "alternative", - "conformations", - "even", - "2007", - "seven", + "knowledge", + "conformational", + "alexander", + "codes", + "respectively", + "determination", + "thus", + "residues", + "level", + "functions", + "subset", "handful", - "topology", + "basis", + "stability", + "approach", + "2007", "proteins", - "maximal", - "effected", - "determining", - "number", - "remains", - "small", + "large", "switching", - "comparable", - "usa", - "structures", - "solution", - "biology", - "stability", - "sci", - "al", + "small", "proc", - "identity", - "large", - "respectively", + "evolution", "higher", - "56", - "detailed", - "code", - "subset", - "functions", - "g", + "unprecedented", "et", - "result", + "al", "88", + "geometries", + "identity", "design", - "nmr", - "describe", - "high", "responsible", + "topology", + "spectroscopy", + "must", + "even", + "biology", + "different", + "16", + "fold", + "leads", + "also", + "code", + "constitute", + "determining", + "solution", + "maintain", "sequence", - "nonidentical", - "codes", "retaining", - "total", - "structural", - "guided", + "levels", + "implications", + "taking", "3d", - "question", - "despite", - "maintain", - "one", + "describe", + "mutation", + "nonidentities", + "folds", "fundamental", - "conformational", - "approach", - "also", - "unprecedented", - "natl", - "fold", + "designed", + "one", + "mutations", + "structures", + "maximal", "95", - "spectroscopy", - "different", - "residues", - "two", - "folds", - "constitute", - "nonidentities", - "implications", - "b", - "protein", - "levels", - "knowledge", - "prevails", + "detailed", + "remains", + "comparable", + "structure", + "monomeric", + "usa", + "provide", + "determined", + "recently", + "nmr", "understanding", + "nonidentical", + "natl", + "high", + "effected", "distinct", - "folding", - "pair", - "level", - "new" + "seven", + "result", + "conformations", + "despite" ], "release_date":"2008-09-09", "publication":"\"NMR structures of two designed proteins with high sequence identity but different fold and function\", Proc.Natl.Acad.Sci.Usa, 105, 14412-14417", @@ -19488,15 +19510,15 @@ }, { "sim":53.0, - "partner":"1gb1" + "partner":"1pga" }, { "sim":53.0, - "partner":"1pga" + "partner":"1pgb" }, { "sim":53.0, - "partner":"1pgb" + "partner":"1gb1" }, { "sim":53.0, @@ -19514,17 +19536,13 @@ "sim":53.0, "partner":"1ibx" }, - { - "sim":53.0, - "partner":"2i38" - }, { "sim":53.0, "partner":"2i2y" }, { - "sim":52.0, - "partner":"2ju6" + "sim":53.0, + "partner":"2i38" }, { "sim":52.0, @@ -19540,11 +19558,11 @@ }, { "sim":52.0, - "partner":"1gb4" + "partner":"2ju6" }, { "sim":52.0, - "partner":"2igh" + "partner":"1gb4" }, { "sim":52.0, @@ -19558,6 +19576,10 @@ "sim":52.0, "partner":"2igd" }, + { + "sim":52.0, + "partner":"2igh" + }, { "sim":51.0, "partner":"8ug0" @@ -19661,115 +19683,115 @@ ], "subtitle":"Solution nmr structures of two designed proteins with 88% sequence identity but different fold and function", "tags":[ - "protein structure", "evolution", "de novo protein", + "protein structure", "folding", "protein design" ], "keywords":[ - "evolution", - "alexander", - "monomeric", - "thus", - "must", - "taking", - "determination", - "designed", - "geometries", - "mutations", - "provide", - "mutation", - "determined", "acad", - "basis", - "therefore", - "structure", + "prevails", "insights", - "16", - "recently", - "leads", + "structural", + "number", + "therefore", + "question", + "56", + "new", + "folding", + "sci", + "protein", + "pair", + "guided", + "b", + "two", + "total", + "g", "alternative", - "conformations", - "even", - "2007", - "seven", + "knowledge", + "conformational", + "alexander", + "codes", + "respectively", + "determination", + "thus", + "residues", + "level", + "functions", + "subset", "handful", - "topology", + "basis", + "stability", + "approach", + "2007", "proteins", - "maximal", - "effected", - "determining", - "number", - "remains", - "small", + "large", "switching", - "comparable", - "usa", - "structures", - "solution", - "biology", - "stability", - "sci", - "al", + "small", "proc", - "identity", - "large", - "respectively", + "evolution", "higher", - "56", - "detailed", - "code", - "subset", - "functions", - "g", + "unprecedented", "et", - "result", + "al", "88", + "geometries", + "identity", "design", - "nmr", - "describe", - "high", "responsible", + "topology", + "spectroscopy", + "must", + "even", + "biology", + "different", + "16", + "fold", + "leads", + "also", + "code", + "constitute", + "determining", + "solution", + "maintain", "sequence", - "nonidentical", - "codes", "retaining", - "total", - "structural", - "guided", + "levels", + "implications", + "taking", "3d", - "question", - "despite", - "maintain", - "one", + "describe", + "mutation", + "nonidentities", + "folds", "fundamental", - "conformational", - "approach", - "also", - "unprecedented", - "natl", - "fold", + "designed", + "one", + "mutations", + "structures", + "maximal", "95", - "spectroscopy", - "different", - "residues", - "two", - "folds", - "constitute", - "nonidentities", - "implications", - "b", - "protein", - "levels", - "knowledge", - "prevails", + "detailed", + "remains", + "comparable", + "structure", + "monomeric", + "usa", + "provide", + "determined", + "recently", + "nmr", "understanding", + "nonidentical", + "natl", + "high", + "effected", "distinct", - "folding", - "pair", - "level", - "new" + "seven", + "result", + "conformations", + "despite" ], "release_date":"2008-09-09", "publication":"\"NMR structures of two designed proteins with high sequence identity but different fold and function\", Proc.Natl.Acad.Sci.Usa, 105, 14412-14417", @@ -19842,21 +19864,13 @@ "sim":71.0, "partner":"1ibx" }, - { - "sim":71.0, - "partner":"2i38" - }, { "sim":71.0, "partner":"2i2y" }, { - "sim":70.0, - "partner":"2ju6" - }, - { - "sim":70.0, - "partner":"1gb1" + "sim":71.0, + "partner":"2i38" }, { "sim":70.0, @@ -19870,6 +19884,10 @@ "sim":70.0, "partner":"2jsv" }, + { + "sim":70.0, + "partner":"1gb1" + }, { "sim":70.0, "partner":"2qmt" @@ -19886,6 +19904,10 @@ "sim":70.0, "partner":"2gb1" }, + { + "sim":70.0, + "partner":"2ju6" + }, { "sim":70.0, "partner":"1uwx" @@ -19930,10 +19952,6 @@ "sim":68.0, "partner":"1gb4" }, - { - "sim":68.0, - "partner":"2igh" - }, { "sim":68.0, "partner":"1igc" @@ -19946,6 +19964,10 @@ "sim":68.0, "partner":"2igd" }, + { + "sim":68.0, + "partner":"2igh" + }, { "sim":67.0, "partner":"2j52" @@ -20077,103 +20099,103 @@ ], "subtitle":"Protein folding on a highly rugged landscape: experimental observation of glassy dynamics and structural frustration", "tags":[ - "de novo protein design", - "non-natural amino acids", "structural frustration", "synthetic protein", + "de novo protein design", "de novo protein", + "non-natural amino acids", "rugged folding energy landscape" ], "keywords":[ - "evolution", - "monomeric", - "results", - "thus", - "door", - "acid", - "place", - "temperatures", - "designed", - "prion", - "near", - "miniprotein", - "fast", + "open", + "emerge", "methods", - "findings", - "basis", - "structure", - "structurally", - "alternative", - "conformations", + "experimental", + "single", + "well", "geological", + "points", + "acid", + "within", + "results", + "folding", + "exhibits", + "protein", + "primordial", + "changes", + "stabilization", + "novo", "places", + "demonstrate", + "physiological", "k", - "accomplish", + "temperatures", + "takes", + "door", + "latent", + "complex", + "alternative", + "conformational", + "timescales", + "furthermore", + "thus", + "biological", + "place", + "basis", "proteins", - "testing", "process", - "de", - "open", - "remains", - "highly", - "competition", + "switching", "cumulative", + "highly", + "degenerate", + "evolution", + "along", + "ensemble", + "compact", + "physical", + "switches", + "design", + "prion", + "benchmarking", + "natural", "simple", + "testing", + "cryogenic", + "selective", "beyond", - "switching", - "evolutionary", - "furthermore", - "theoretically", + "amino", + "sequence", + "near", + "mechanism", + "evolved", + "folds", "dynamics", - "structures", - "natural", + "accomplish", + "evolutionary", + "designed", "branching", "involves", - "native", - "physical", - "evolved", - "benchmarking", - "early", - "amino", - "exhibits", - "timescales", - "changes", + "poorly", + "theoretically", + "structurally", + "structures", + "competing", + "de", + "competition", + "remains", + "structure", + "monomeric", + "introduce", + "findings", + "fast", "temperature", "exploration", - "physiological", - "points", - "design", - "introduce", - "switches", - "competing", - "sequence", - "biological", - "ensemble", - "compact", - "stabilization", - "demonstrate", - "poorly", - "conformational", - "latent", - "novo", - "single", - "along", - "experimental", - "well", - "emerge", - "takes", - "folds", "primitive", - "mechanism", - "selective", - "protein", - "primordial", - "complex", - "within", "diseases", - "folding", - "cryogenic", - "degenerate" + "native", + "early", + "conformations", + "miniprotein" ], "release_date":"2009-06-16", "publication":"\"A designed protein as experimental model of primordial folding\", Proc.Natl.Acad.Sci.USA, 106, 4127-4132", @@ -20284,84 +20306,84 @@ ], "subtitle":"Nmr structures of ga95 and gb95, two designed proteins with 95% sequence identity but different folds and functions", "tags":[ - "human serum albumin binding protein", + "evolution", "protein design", "folding", - "evolution" + "human serum albumin binding protein" ], "keywords":[ + "affinity", + "c", + "stably", + "conformation", + "bifunctional", + "path", + "conformational", + "space", + "structural", "one", "another", - "amino", - "proteins", - "via", - "pathway", - "substitution", - "conformational", - "similar", - "approach", + "mechanistic", + "show", + "key", "mutational", - "changes", + "exists", + "igg", + "structures", "single", - "along", - "acid", - "90", - "stably", - "fold", - "point", - "explanation", - "switch", "different", - "lost", - "stabilities", - "simplified", + "side", + "via", + "structure", + "neither", + "fold", + "provided", "description", - "functions", - "iii", - "switching", - "mutation", - "bifunctional", - "folds", + "acid", "determined", - "folded", - "transformed", - "ii", - "show", - "explore", - "mechanism", - "mechanistic", - "exists", - "structures", - "protein", - "occur", - "conformation", - "2", - "present", + "populated", + "point", + "functions", "degrees", - "path", "switches", - "space", + "explore", "nmr", - "structure", + "transformed", + "protein", + "occur", + "folded", "function", - "sequence", - "c", + "completely", + "approach", + "amino", + "ph", + "proteins", + "20", + "mutants", + "changes", + "switching", + "explanation", + "2", + "lost", + "iii", "native", + "pathway", + "sequence", + "90", + "stabilities", "albumin", + "simplified", + "switch", + "along", + "present", + "substitution", "evaluated", - "neither", - "populated", - "key", - "mutants", - "ph", - "20", - "side", - "affinity", - "completely", - "structural", + "mechanism", "create", - "igg", - "provided" + "mutation", + "folds", + "similar", + "ii" ], "release_date":"2009-12-29", "publication":"\"A minimal sequence code for switching protein structure and function\", Proc.Natl.Acad.Sci.USA, 106, 21149-21154", @@ -20465,84 +20487,84 @@ ], "subtitle":"Nmr structures of ga95 and gb95, two designed proteins with 95% sequence identity but different folds and functions", "tags":[ - "igg binding protein", + "evolution", "protein design", - "folding", - "evolution" + "igg binding protein", + "folding" ], "keywords":[ + "affinity", + "c", + "stably", + "conformation", + "bifunctional", + "path", + "conformational", + "space", + "structural", "one", "another", - "amino", - "proteins", - "via", - "pathway", - "substitution", - "conformational", - "similar", - "approach", + "mechanistic", + "show", + "key", "mutational", - "changes", + "exists", + "igg", + "structures", "single", - "along", - "acid", - "90", - "stably", - "fold", - "point", - "explanation", - "switch", "different", - "lost", - "stabilities", - "simplified", + "side", + "via", + "structure", + "neither", + "fold", + "provided", "description", - "functions", - "iii", - "switching", - "mutation", - "bifunctional", - "folds", + "acid", "determined", - "folded", - "transformed", - "ii", - "show", - "explore", - "mechanism", - "mechanistic", - "exists", - "structures", - "protein", - "occur", - "conformation", - "2", - "present", + "populated", + "point", + "functions", "degrees", - "path", "switches", - "space", + "explore", "nmr", - "structure", + "transformed", + "protein", + "occur", + "folded", "function", - "sequence", - "c", + "completely", + "approach", + "amino", + "ph", + "proteins", + "20", + "mutants", + "changes", + "switching", + "explanation", + "2", + "lost", + "iii", "native", + "pathway", + "sequence", + "90", + "stabilities", "albumin", + "simplified", + "switch", + "along", + "present", + "substitution", "evaluated", - "neither", - "populated", - "key", - "mutants", - "ph", - "20", - "side", - "affinity", - "completely", - "structural", + "mechanism", "create", - "igg", - "provided" + "mutation", + "folds", + "similar", + "ii" ], "release_date":"2009-12-29", "publication":"\"From the Cover: A minimal sequence code for switching protein structure and function\", Proc.Natl.Acad.Sci.USA, 106, 21149-21154", @@ -20662,35 +20684,35 @@ ], "subtitle":"Nmr structure of a de novo designed beta alpha beta", "tags":[ - "beta-alpha-beta", - "de novo protein" + "de novo protein", + "beta-alpha-beta" ], "keywords":[ - "stability", - "thermal", + "beta", + "due", + "structure", "monomeric", - "strands", - "amino", - "connected", - "large", - "extent", "fold", - "acids", - "see", - "constructed", - "two", - "due", - "parallel", - "protein", - "interactions", "helix", - "structure", + "connected", + "thermal", + "interactions", + "protein", + "solely", + "amino", + "stability", + "constructed", + "large", + "alpha", + "strands", "high", + "see", "coded", - "alpha", - "beta", - "solely", - "designer" + "designer", + "parallel", + "acids", + "two", + "extent" ], "release_date":"2009-10-20", "publication":"\"De novo design of a beta alpha beta motif\", Angew.Chem.Int.Ed.Engl., 48, 3301-3303", @@ -20807,11 +20829,11 @@ ], "subtitle":"An artificial di-iron oxo-protein with phenol oxidase activity", "tags":[ - "oxidase", - "four-heix bundle", "diiron proteins", + "de novo design", + "oxidase", "de novo protein", - "de novo design" + "four-heix bundle" ], "keywords":[ "description", @@ -20915,91 +20937,91 @@ "amphipathic peptide" ], "keywords":[ - "require", - "acidic", - "thus", - "potent", - "suggest", - "including", - "provide", - "hinge", - "concomitantly", - "transfection", - "interactions", - "conformation", + "membranes", + "moment", + "hydrophobic", + "orientations", "therefore", - "structure", - "conformations", - "histidines", - "detergent", - "membrane", - "investigated", - "dna", - "solutions", - "family", - "less", - "electrostatic", - "strongly", + "pk", "presence", - "resulting", - "degree", - "bilayer", "lead", - "uncharged", - "structures", - "facilitates", - "mixture", - "view", - "micellar", - "cellular", - "hinged", - "transmembrane", - "discussed", - "solvent", - "data", - "obtained", - "exhibits", - "conditions", - "antimicrobial", "extended", - "discharged", - "changes", + "exhibits", + "hinged", "activities", - "alignments", - "repulsion", - "9", - "region", - "shown", - "activity", + "ph", "helical", + "changes", + "cellular", + "forms", + "region", + "stable", + "conformation", + "alignments", + "conformational", + "transfection", + "mixture", + "dna", + "concomitantly", + "thus", + "residues", + "family", "occur", - "hydrophobic", + "discharged", + "strongly", + "degree", + "adopts", + "suggest", "stroboscopic", + "density", + "bilayer", + "24", + "lah4", + "including", + "values", + "obtained", + "encompassing", + "dpc", "context", + "electrostatic", "insertion", + "shown", + "9", + "micellar", + "conditions", + "anchoring", + "plasticity", + "hinge", + "view", + "peptides", + "antimicrobial", + "require", + "investigated", "association", - "orientations", - "high", "histidine", - "ph", - "lah4", - "moment", + "transmembrane", + "structures", + "repulsion", + "structure", + "acidic", + "solutions", + "provide", + "resulting", + "interactions", + "membrane", + "histidines", + "uncharged", + "facilitates", + "high", + "discussed", + "activity", + "detergent", + "conformations", + "solvent", + "potent", + "data", "decrease", - "dpc", - "density", - "membranes", - "values", - "conformational", - "stable", - "anchoring", - "pk", - "peptides", - "residues", - "encompassing", - "24", - "adopts", - "forms", - "plasticity" + "less" ], "release_date":"2010-06-23", "publication":"\"NMR structures of the histidine-rich peptide LAH4 in micellar environments: membrane insertion, pH-dependent mode of antimicrobial action, and DNA transfection\", Biophys.J., 99, 2507-2515", @@ -21095,95 +21117,95 @@ ], "subtitle":"Ph dependent structures of lah4 in micellar environment: mode of acting", "tags":[ - "lah4 neutral", - "de novo protein" + "de novo protein", + "lah4 neutral" ], "keywords":[ - "require", - "acidic", - "thus", - "potent", - "suggest", - "including", - "provide", - "hinge", - "concomitantly", - "transfection", - "interactions", - "conformation", + "membranes", + "moment", + "hydrophobic", + "orientations", "therefore", - "structure", - "conformations", - "histidines", - "detergent", - "membrane", - "investigated", - "dna", - "solutions", - "family", - "less", - "electrostatic", - "strongly", + "pk", "presence", - "resulting", - "degree", - "bilayer", "lead", - "uncharged", - "structures", - "facilitates", - "mixture", - "view", - "micellar", - "cellular", - "hinged", - "transmembrane", - "discussed", - "solvent", - "data", - "obtained", - "exhibits", - "conditions", - "antimicrobial", "extended", - "discharged", - "changes", + "exhibits", + "hinged", "activities", - "alignments", - "repulsion", - "9", - "region", - "shown", - "activity", + "ph", "helical", + "changes", + "cellular", + "forms", + "region", + "stable", + "conformation", + "alignments", + "conformational", + "transfection", + "mixture", + "dna", + "concomitantly", + "thus", + "residues", + "family", "occur", - "hydrophobic", + "discharged", + "strongly", + "degree", + "adopts", + "suggest", "stroboscopic", + "density", + "bilayer", + "24", + "lah4", + "including", + "values", + "obtained", + "encompassing", + "dpc", "context", + "electrostatic", "insertion", + "shown", + "9", + "micellar", + "conditions", + "anchoring", + "plasticity", + "hinge", + "view", + "peptides", + "antimicrobial", + "require", + "investigated", "association", - "orientations", - "high", "histidine", - "ph", - "lah4", - "moment", + "transmembrane", + "structures", + "repulsion", + "structure", + "acidic", + "solutions", + "provide", + "resulting", + "interactions", + "membrane", + "histidines", + "uncharged", + "facilitates", + "high", + "discussed", + "activity", + "detergent", + "conformations", + "solvent", + "potent", + "data", "decrease", - "dpc", - "density", - "membranes", - "values", - "conformational", - "stable", - "anchoring", - "pk", - "peptides", - "residues", - "encompassing", - "24", - "adopts", - "forms", - "plasticity" + "less" ], "release_date":"2010-06-23", "publication":"\"NMR structures of the histidine-rich peptide LAH4 in micellar environments: membrane insertion, pH-dependent mode of antimicrobial action, and DNA transfection\", Biophys.J., 99, 2507-2515", @@ -21296,105 +21318,105 @@ ], "subtitle":"Solution nmr structure of de novo designed ferredoxin-like fold protein, northeast structural genomics consortium target or15", "tags":[ - "psi-2", - "ferrodoxin fold", "target or15", - "structural genomics", - "protein structure initiative", "de novo protein", + "ferrodoxin fold", + "structural genomics", "northeast structural genomics consortium (nesg)", - "protein nmr" + "psi-2", + "protein nmr", + "protein structure initiative" ], "keywords":[ - "evolution", - "ordered", - "monomeric", - "results", - "selection", - "strained", - "designed", - "example", - "provide", - "local", - "heteropolymers", - "target", - "features", - "based", - "sequences", - "interactions", + "engineering", "adopt", - "designing", - "structure", - "minimal", - "consistent", - "relating", - "neutral", - "proteins", - "models", - "drift", - "unique", - "random", - "landscapes", - "evolutionary", - "folded", - "arise", - "structures", - "kinked", - "complicated", - "buried", - "unfavourable", - "foundation", - "natural", - "solution", - "tertiary", - "function", - "motifs", - "nearly", - "rules", + "strained", "free", - "generation", - "loops", - "functional", + "results", + "new", + "make", + "folding", + "protein", "topologies", - "bulged", - "engineering", - "design", + "unfavourable", + "guided", "energetically", + "motifs", "secondary", - "describe", - "stabilized", + "stable", + "rules", "encoded", + "tertiary", + "illuminate", + "relating", + "nearly", + "ideal", + "drift", "biological", - "energy", - "funnels", + "consistent", + "polar", + "buried", + "folded", "completely", - "predicted", - "guided", - "make", - "consisting", - "designs", - "groups", - "patterns", "approach", - "stable", - "fold", - "different", + "proteins", "found", - "leading", - "illuminate", - "state", - "polar", - "ideal", + "evolution", + "features", + "computational", "set", - "protein", + "local", + "designing", + "design", + "energy", + "selection", + "bulged", + "heteropolymers", + "loops", + "natural", + "functional", + "possible", + "different", + "arise", + "consisting", + "fold", + "groups", + "leading", + "solution", + "foundation", + "complicated", + "predicted", "identical", - "understanding", - "computational", + "unique", + "describe", + "minimal", + "funnels", + "landscapes", + "evolutionary", + "designed", + "example", + "models", + "generation", + "sequences", "unlike", - "folding", - "possible", - "five", - "new" + "structures", + "based", + "structure", + "monomeric", + "provide", + "target", + "interactions", + "state", + "patterns", + "function", + "understanding", + "random", + "neutral", + "designs", + "ordered", + "stabilized", + "kinked", + "five" ], "release_date":"2009-07-28", "publication":"\"Principles for designing ideal protein structures\", Nature, 491, 222-227", @@ -21550,114 +21572,114 @@ ], "subtitle":"Solution structure of an abc collagen heterotrimer reveals a single-register helix stabilized by electrostatic interactions", "tags":[ + "de novo protein", "heterotrimer", "collagen", - "de novo protein", "synthetic peptide" ], "keywords":[ - "domain", - "predominance", - "many", - "constructs", - "studies", - "stabilizing", - "issue", - "peptide", - "triple", - "register", - "obtain", - "find", - "based", + "defined", + "role", + "collagen", + "structural", + "resolution", "show", - "homeostatic", + "well", + "information", + "regulation", + "pathological", + "within", + "collagenous", + "folding", "assembled", - "interactions", - "reason", - "structure", + "insight", + "protein", "solely", - "addresses", - "without", - "participation", - "although", - "family", - "determining", - "heterogeneity", - "almost", - "electrostatic", - "processes", - "used", - "difficult", - "implicated", - "motif", - "nature", - "collagen", + "globular", "controlling", - "heterotrimer", + "helical", + "motif", "charged", - "natural", - "solution", - "native", + "domains", + "researched", + "register", + "tissues", + "helices", + "chains", + "encoded", "either", - "size", - "form", - "first", - "role", - "pathological", - "highlights", - "stability", - "obtained", - "regulation", - "defined", - "factors", - "common", - "report", - "globular", - "resolution", + "implicated", + "stabilizing", "heterotrimers", - "information", - "may", - "gain", + "almost", + "residues", "specific", - "mammals", - "choose", + "helix", + "family", + "factors", + "although", + "stability", + "heterotrimer", + "size", "several", - "biochemistry", + "may", + "triple", + "unclear", + "peptide", + "obtained", + "addresses", + "predominance", "design", - "helical", + "electrostatic", + "reason", + "used", + "natural", + "highlights", + "possible", + "environment", + "domain", + "processes", + "choose", + "also", + "humans", + "determining", + "biochemistry", + "solution", + "types", "selectively", - "nmr", - "high", + "participation", "homotrimers", - "encoded", - "known", - "structural", - "important", + "common", + "peptides", + "assistance", + "mechanism", + "obtain", + "form", "actively", - "unclear", - "chains", - "helices", - "also", "collagens", + "many", + "constructs", + "mammals", + "first", + "issue", + "based", + "without", + "structure", + "important", + "report", + "nmr", + "interactions", + "nature", + "known", + "homeostatic", + "find", + "gain", + "high", + "native", + "difficult", + "studies", "composition", - "collagenous", - "insight", - "peptides", - "humans", - "well", - "residues", - "tissues", - "domains", - "mechanism", - "protein", - "helix", - "researched", - "types", - "environment", - "within", - "folding", - "possible", - "assistance" + "heterogeneity" ], "release_date":"2009-07-21", "publication":"\"Solution structure of an ABC collagen heterotrimer reveals a single-register helix stabilized by electrostatic interactions\", J.Biol.Chem., 284, 26851-26859", @@ -21760,9 +21782,9 @@ ], "subtitle":"Solution structure of nasonin-1", "tags":[ - "alpha\/beta structure", "de novo protein", - "disulfide bonds" + "disulfide bonds", + "alpha\/beta structure" ], "keywords":[ "description", @@ -21874,9 +21896,9 @@ ], "subtitle":"Solution structure of nasonin-1m", "tags":[ - "alpha\/beta structure", "de novo protein", - "disulfide bonds" + "disulfide bonds", + "alpha\/beta structure" ], "keywords":[ "description", @@ -21989,14 +22011,14 @@ ], "subtitle":"Solution nmr structure of de novo designed rossmann 2x2 fold protein, northeast structural genomics consortium target or16", "tags":[ - "psi-2", - "de novo designed", + "nesg", + "de novo protein", + "rossmann fold", "northeast structural genomics consortium", + "de novo designed", "structural genomics", + "psi-2", "protein structure initiative", - "rossmann fold", - "de novo protein", - "nesg", "gft nmr" ], "keywords":[ @@ -22186,12 +22208,12 @@ ], "subtitle":"Solution nmr structure of de novo designed protein, p-loop ntpase fold, northeast structural genomics consortium target or28", "tags":[ - "structural genomics", - "protein structure initiative", "de novo protein", - "psi-biology", "unknown function", - "northeast structural genomics consortium (nesg)" + "psi-biology", + "structural genomics", + "northeast structural genomics consortium (nesg)", + "protein structure initiative" ], "keywords":[ "description", @@ -22356,9 +22378,9 @@ ], "subtitle":"Solution nmr structure of de novo designed protein, p-loop ntpase fold, northeast structural genomics consortium target or32", "tags":[ - "protein structure initiative", - "northeast structural genomics consortium (nesg) psi-biology", "de novo protein", + "northeast structural genomics consortium (nesg) psi-biology", + "protein structure initiative", "structural genomics" ], "keywords":[ @@ -22519,136 +22541,136 @@ ], "subtitle":"Solution structure of lak160-p7", "tags":[ + "de novo protein, antimicrobial protein", "proline", + "de novo protein", + "antimicrobial protein", "cationic", + "ampiphatic" + ], + "keywords":[ + "description", + "found" + ], + "release_date":"2012-02-01", + "publication":"To be published", + "publication_ref":{ + "DOI":"", + "PubMed":"", + "CSD":"", + "ISSN":"", + "ASTM":"" + }, + "publication_country":"", + "abstract":"No description found.", + "crystal_structure":{ + "length_a":"1.000", + "length_b":"1.000", + "length_c":"1.000", + "angle_a":"90.00", + "angle_b":"90.00", + "angle_g":"90.00" + }, + "symmetry":"P 1", + "exptl_method":[ + "SOLUTION NMR" + ], + "formula_weight":2666.508, + "synthesis_comment":"Synthesized by solid phase synthesis", + "review":true, + "previous_design":"2l82", + "next_design":"2l99", + "seq_thr_sim_designed":[ + + ], + "seq_thr_sim_natural":[ + + ], + "struct_thr_sim_designed":[ + + ], + "struct_thr_sim_natural":[ + + ], + "seq_max_sim_designed":{ + "sim":34.0, + "partner":"2l99" + }, + "seq_max_sim_natural":[ + + ], + "struct_max_sim_designed":{ + "sim":0.6822999716, + "partner":"2l99" + }, + "struct_max_sim_natural":[ + + ], + "review_comment":[ + "" + ] + }, + { + "pdb":"2l99", + "picture_path":"https:\/\/cdn.rcsb.org\/images\/structures\/2l99_assembly-1.jpeg", + "chains":[ + { + "chain_id":"X", + "chain_source":"unknown", + "chain_type":"U", + "chain_seq_unnat":"KKLKLALAKPALLWKALALKLKKA", + "chain_seq_nat":"KKLKLALAKPALLWKALALKLKKA", + "chain_length":24 + } + ], + "authors":[ + { + "forename":"L.S.", + "surname":"Vermeer" + }, + { + "forename":"T.T.", + "surname":"Bui" + }, + { + "forename":"Y.", + "surname":"Lan" + }, + { + "forename":"E.", + "surname":"Jumagulova" + }, + { + "forename":"J.", + "surname":"Kozlowska" + }, + { + "forename":"C.", + "surname":"McIntyre" + }, + { + "forename":"A.F.", + "surname":"Drake" + }, + { + "forename":"J.A.", + "surname":"Mason" + } + ], + "classification":"unknown", + "classification_suggested":[ + + ], + "classification_suggested_reason":[ + + ], + "subtitle":"Solution structure of lak160-p10", + "tags":[ "de novo protein, antimicrobial protein", + "proline", "de novo protein", "antimicrobial protein", - "ampiphatic" - ], - "keywords":[ - "description", - "found" - ], - "release_date":"2012-02-01", - "publication":"To be published", - "publication_ref":{ - "DOI":"", - "PubMed":"", - "CSD":"", - "ISSN":"", - "ASTM":"" - }, - "publication_country":"", - "abstract":"No description found.", - "crystal_structure":{ - "length_a":"1.000", - "length_b":"1.000", - "length_c":"1.000", - "angle_a":"90.00", - "angle_b":"90.00", - "angle_g":"90.00" - }, - "symmetry":"P 1", - "exptl_method":[ - "SOLUTION NMR" - ], - "formula_weight":2666.508, - "synthesis_comment":"Synthesized by solid phase synthesis", - "review":true, - "previous_design":"2l82", - "next_design":"2l99", - "seq_thr_sim_designed":[ - - ], - "seq_thr_sim_natural":[ - - ], - "struct_thr_sim_designed":[ - - ], - "struct_thr_sim_natural":[ - - ], - "seq_max_sim_designed":{ - "sim":34.0, - "partner":"2l9a" - }, - "seq_max_sim_natural":[ - - ], - "struct_max_sim_designed":{ - "sim":0.6822999716, - "partner":"2l99" - }, - "struct_max_sim_natural":[ - - ], - "review_comment":[ - "" - ] - }, - { - "pdb":"2l99", - "picture_path":"https:\/\/cdn.rcsb.org\/images\/structures\/2l99_assembly-1.jpeg", - "chains":[ - { - "chain_id":"X", - "chain_source":"unknown", - "chain_type":"U", - "chain_seq_unnat":"KKLKLALAKPALLWKALALKLKKA", - "chain_seq_nat":"KKLKLALAKPALLWKALALKLKKA", - "chain_length":24 - } - ], - "authors":[ - { - "forename":"L.S.", - "surname":"Vermeer" - }, - { - "forename":"T.T.", - "surname":"Bui" - }, - { - "forename":"Y.", - "surname":"Lan" - }, - { - "forename":"E.", - "surname":"Jumagulova" - }, - { - "forename":"J.", - "surname":"Kozlowska" - }, - { - "forename":"C.", - "surname":"McIntyre" - }, - { - "forename":"A.F.", - "surname":"Drake" - }, - { - "forename":"J.A.", - "surname":"Mason" - } - ], - "classification":"unknown", - "classification_suggested":[ - - ], - "classification_suggested_reason":[ - - ], - "subtitle":"Solution structure of lak160-p10", - "tags":[ - "proline", - "cationic", - "de novo protein, antimicrobial protein", - "de novo protein", - "antimicrobial protein", + "cationic", "ampiphatic" ], "keywords":[ @@ -22697,7 +22719,7 @@ ], "seq_max_sim_designed":{ "sim":34.0, - "partner":"2l9a" + "partner":"2l96" }, "seq_max_sim_natural":[ @@ -22769,11 +22791,11 @@ ], "subtitle":"Solution structure of lak160-p12", "tags":[ - "proline", - "cationic", "de novo protein, antimicrobial protein", + "proline", "de novo protein", "antimicrobial protein", + "cationic", "ampiphatic" ], "keywords":[ @@ -22907,11 +22929,11 @@ ], "subtitle":"Solution nmr structure of de novo designed protein, p-loop ntpase fold, northeast structural genomics consortium target or36 (casd target)", "tags":[ - "northeast structural genomics consortium", - "structural genomics", "protein structure initiative", - "de novo protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", + "structural genomics", "psi-biology" ], "keywords":[ @@ -22973,11 +22995,11 @@ }, { "sim":60.0, - "partner":"2kpo" + "partner":"2lv8" }, { "sim":60.0, - "partner":"2lv8" + "partner":"2kpo" }, { "sim":57.0, @@ -23063,74 +23085,74 @@ "de novo protein" ], "keywords":[ - "diverse", - "evolution", - "ordered", - "rare", - "3\u03b1", - "monomeric", + "relatively", + "designed", + "periphery", + "characterized", + "likelihood", "one", - "results", - "amino", - "proteins", - "studies", - "multiple", - "common", + "insights", + "show", + "mutations", "mutational", - "tip", - "changes", + "diverse", + "requirements", + "even", + "regarded", "single", - "transitioning", - "characterized", - "acid", - "balance", - "immunoglobulin", - "fold", - "unbound", - "designed", - "illustrate", - "switch", "well", - "different", - "functions", - "relevant", - "mutations", - "provide", - "switching", - "rearrangements", + "multiple", "examine", - "periphery", - "folds", - "system", - "ways", - "ability", - "folded", - "generally", - "show", "core", - "protein", - "occur", + "different", + "rearrangements", + "transitions", + "monomeric", + "fold", + "acid", + "populated", + "results", + "new", "residue", - "positions", - "raising", - "switches", - "requirements", "successive", - "states", + "provide", "disordered", - "transitions", - "relatively", + "functions", + "occur", + "transitioning", + "relevant", + "protein", + "folded", + "amino", + "completely", + "positions", + "illustrate", "function", - "regarded", + "proteins", + "appreciably", + "generally", + "changes", + "switching", + "ways", + "ability", + "rare", "alternatively", - "insights", - "populated", + "states", + "system", + "common", + "unbound", + "immunoglobulin", + "switch", + "evolution", + "studies", + "tip", + "balance", "gained", - "likelihood", - "completely", - "appreciably", - "even", - "new" + "raising", + "3\u03b1", + "ordered", + "folds", + "switches" ], "release_date":"2012-02-29", "publication":"\"Mutational tipping points for switching protein folds and functions\", Structure, 20, 283-291", @@ -23217,11 +23239,11 @@ }, { "sim":61.0, - "partner":"2i38" + "partner":"2i2y" }, { "sim":61.0, - "partner":"2i2y" + "partner":"2i38" }, { "sim":61.0, @@ -23237,15 +23259,15 @@ }, { "sim":60.0, - "partner":"1gb1" + "partner":"1pga" }, { "sim":60.0, - "partner":"1pga" + "partner":"1pgb" }, { "sim":60.0, - "partner":"1pgb" + "partner":"1gb1" }, { "sim":60.0, @@ -23285,52 +23307,48 @@ }, { "sim":59.0, - "partner":"2ju6" + "partner":"2k0p" }, { "sim":59.0, - "partner":"2kwd" + "partner":"2jsv" }, { "sim":59.0, - "partner":"2k0p" + "partner":"2lgi" }, { "sim":59.0, - "partner":"8ug0" + "partner":"2qmt" }, { "sim":59.0, - "partner":"8ug2" + "partner":"8ug0" }, { "sim":59.0, - "partner":"2jsv" + "partner":"8ug2" }, { "sim":59.0, - "partner":"2lgi" + "partner":"2gi9" }, { "sim":59.0, - "partner":"2qmt" + "partner":"2kq4" }, { "sim":59.0, - "partner":"2gi9" + "partner":"2kwd" }, { "sim":59.0, - "partner":"2kq4" + "partner":"2ju6" }, { "sim":59.0, "partner":"1fd6" }, - { - "sim":59.0, - "partner":"2igh" - }, { "sim":59.0, "partner":"1igc" @@ -23343,17 +23361,21 @@ "sim":59.0, "partner":"2igd" }, + { + "sim":59.0, + "partner":"2igh" + }, { "sim":58.0, "partner":"2plp" }, { "sim":58.0, - "partner":"2klk" + "partner":"2rmm" }, { "sim":58.0, - "partner":"2rmm" + "partner":"2klk" }, { "sim":58.0, @@ -23505,74 +23527,74 @@ "de novo protein" ], "keywords":[ - "diverse", - "evolution", - "ordered", - "rare", - "3\u03b1", - "monomeric", + "relatively", + "designed", + "periphery", + "characterized", + "likelihood", "one", - "results", - "amino", - "proteins", - "studies", - "multiple", - "common", + "insights", + "show", + "mutations", "mutational", - "tip", - "changes", + "diverse", + "requirements", + "even", + "regarded", "single", - "transitioning", - "characterized", - "acid", - "balance", - "immunoglobulin", - "fold", - "unbound", - "designed", - "illustrate", - "switch", "well", - "different", - "functions", - "relevant", - "mutations", - "provide", - "switching", - "rearrangements", + "multiple", "examine", - "periphery", - "folds", - "system", - "ways", - "ability", - "folded", - "generally", - "show", "core", - "protein", - "occur", + "different", + "rearrangements", + "transitions", + "monomeric", + "fold", + "acid", + "populated", + "results", + "new", "residue", - "positions", - "raising", - "switches", - "requirements", "successive", - "states", + "provide", "disordered", - "transitions", - "relatively", + "functions", + "occur", + "transitioning", + "relevant", + "protein", + "folded", + "amino", + "completely", + "positions", + "illustrate", "function", - "regarded", + "proteins", + "appreciably", + "generally", + "changes", + "switching", + "ways", + "ability", + "rare", "alternatively", - "insights", - "populated", + "states", + "system", + "common", + "unbound", + "immunoglobulin", + "switch", + "evolution", + "studies", + "tip", + "balance", "gained", - "likelihood", - "completely", - "appreciably", - "even", - "new" + "raising", + "3\u03b1", + "ordered", + "folds", + "switches" ], "release_date":"2012-02-29", "publication":"\"Mutational tipping points for switching protein folds and functions\", Structure, 20, 283-291", @@ -23659,11 +23681,11 @@ }, { "sim":64.0, - "partner":"2i38" + "partner":"2i2y" }, { "sim":64.0, - "partner":"2i2y" + "partner":"2i38" }, { "sim":64.0, @@ -23677,22 +23699,10 @@ "sim":64.0, "partner":"3ui3" }, - { - "sim":63.0, - "partner":"2ju6" - }, - { - "sim":63.0, - "partner":"2kwd" - }, { "sim":63.0, "partner":"2k0p" }, - { - "sim":63.0, - "partner":"1gb1" - }, { "sim":63.0, "partner":"1pga" @@ -23705,6 +23715,10 @@ "sim":63.0, "partner":"2jsv" }, + { + "sim":63.0, + "partner":"1gb1" + }, { "sim":63.0, "partner":"2lgi" @@ -23725,13 +23739,17 @@ "sim":63.0, "partner":"2kq4" }, + { + "sim":63.0, + "partner":"2kwd" + }, { "sim":63.0, "partner":"2gb1" }, { "sim":63.0, - "partner":"2igh" + "partner":"2ju6" }, { "sim":63.0, @@ -23745,6 +23763,10 @@ "sim":63.0, "partner":"2igd" }, + { + "sim":63.0, + "partner":"2igh" + }, { "sim":63.0, "partner":"1uwx" @@ -23795,11 +23817,11 @@ }, { "sim":61.0, - "partner":"2klk" + "partner":"2rmm" }, { "sim":61.0, - "partner":"2rmm" + "partner":"2klk" }, { "sim":61.0, @@ -23943,74 +23965,74 @@ "de novo protein" ], "keywords":[ - "diverse", - "evolution", - "ordered", - "rare", - "3\u03b1", - "monomeric", + "relatively", + "designed", + "periphery", + "characterized", + "likelihood", "one", - "results", - "amino", - "proteins", - "studies", - "multiple", - "common", + "insights", + "show", + "mutations", "mutational", - "tip", - "changes", + "diverse", + "requirements", + "even", + "regarded", "single", - "transitioning", - "characterized", - "acid", - "balance", - "immunoglobulin", - "fold", - "unbound", - "designed", - "illustrate", - "switch", "well", - "different", - "functions", - "relevant", - "mutations", - "provide", - "switching", - "rearrangements", + "multiple", "examine", - "periphery", - "folds", - "system", - "ways", - "ability", - "folded", - "generally", - "show", "core", - "protein", - "occur", + "different", + "rearrangements", + "transitions", + "monomeric", + "fold", + "acid", + "populated", + "results", + "new", "residue", - "positions", - "raising", - "switches", - "requirements", "successive", - "states", + "provide", "disordered", - "transitions", - "relatively", + "functions", + "occur", + "transitioning", + "relevant", + "protein", + "folded", + "amino", + "completely", + "positions", + "illustrate", "function", - "regarded", + "proteins", + "appreciably", + "generally", + "changes", + "switching", + "ways", + "ability", + "rare", "alternatively", - "insights", - "populated", + "states", + "system", + "common", + "unbound", + "immunoglobulin", + "switch", + "evolution", + "studies", + "tip", + "balance", "gained", - "likelihood", - "completely", - "appreciably", - "even", - "new" + "raising", + "3\u03b1", + "ordered", + "folds", + "switches" ], "release_date":"2012-02-29", "publication":"\"Mutational tipping points for switching protein folds and functions\", Structure, 20, 283-291", @@ -24089,11 +24111,11 @@ }, { "sim":64.0, - "partner":"2i38" + "partner":"2i2y" }, { "sim":64.0, - "partner":"2i2y" + "partner":"2i38" }, { "sim":64.0, @@ -24109,15 +24131,15 @@ }, { "sim":63.0, - "partner":"1gb1" + "partner":"1pga" }, { "sim":63.0, - "partner":"1pga" + "partner":"1pgb" }, { "sim":63.0, - "partner":"1pgb" + "partner":"1gb1" }, { "sim":63.0, @@ -24167,14 +24189,6 @@ "sim":63.0, "partner":"2khw" }, - { - "sim":62.0, - "partner":"2ju6" - }, - { - "sim":62.0, - "partner":"2kwd" - }, { "sim":62.0, "partner":"2k0p" @@ -24201,11 +24215,15 @@ }, { "sim":62.0, - "partner":"1fd6" + "partner":"2kwd" }, { "sim":62.0, - "partner":"2igh" + "partner":"2ju6" + }, + { + "sim":62.0, + "partner":"1fd6" }, { "sim":62.0, @@ -24220,12 +24238,12 @@ "partner":"2igd" }, { - "sim":61.0, - "partner":"2plp" + "sim":62.0, + "partner":"2igh" }, { "sim":61.0, - "partner":"2klk" + "partner":"2plp" }, { "sim":61.0, @@ -24239,6 +24257,10 @@ "sim":61.0, "partner":"2rmm" }, + { + "sim":61.0, + "partner":"2klk" + }, { "sim":60.0, "partner":"2nmq" @@ -24381,74 +24403,74 @@ "de novo protein" ], "keywords":[ - "diverse", - "evolution", - "ordered", - "rare", - "3\u03b1", - "monomeric", + "relatively", + "designed", + "periphery", + "characterized", + "likelihood", "one", - "results", - "amino", - "proteins", - "studies", - "multiple", - "common", + "insights", + "show", + "mutations", "mutational", - "tip", - "changes", + "diverse", + "requirements", + "even", + "regarded", "single", - "transitioning", - "characterized", - "acid", - "balance", - "immunoglobulin", - "fold", - "unbound", - "designed", - "illustrate", - "switch", "well", - "different", - "functions", - "relevant", - "mutations", - "provide", - "switching", - "rearrangements", + "multiple", "examine", - "periphery", - "folds", - "system", - "ways", - "ability", - "folded", - "generally", - "show", "core", - "protein", - "occur", + "different", + "rearrangements", + "transitions", + "monomeric", + "fold", + "acid", + "populated", + "results", + "new", "residue", - "positions", - "raising", - "switches", - "requirements", "successive", - "states", + "provide", "disordered", - "transitions", - "relatively", + "functions", + "occur", + "transitioning", + "relevant", + "protein", + "folded", + "amino", + "completely", + "positions", + "illustrate", "function", - "regarded", + "proteins", + "appreciably", + "generally", + "changes", + "switching", + "ways", + "ability", + "rare", "alternatively", - "insights", - "populated", + "states", + "system", + "common", + "unbound", + "immunoglobulin", + "switch", + "evolution", + "studies", + "tip", + "balance", "gained", - "likelihood", - "completely", - "appreciably", - "even", - "new" + "raising", + "3\u03b1", + "ordered", + "folds", + "switches" ], "release_date":"2012-02-29", "publication":"\"Mutational tipping points for switching protein folds and functions\", Structure, 20, 283-291", @@ -24527,11 +24549,11 @@ }, { "sim":62.0, - "partner":"2i38" + "partner":"2i2y" }, { "sim":62.0, - "partner":"2i2y" + "partner":"2i38" }, { "sim":62.0, @@ -24547,15 +24569,15 @@ }, { "sim":61.0, - "partner":"1gb1" + "partner":"1pga" }, { "sim":61.0, - "partner":"1pga" + "partner":"1pgb" }, { "sim":61.0, - "partner":"1pgb" + "partner":"1gb1" }, { "sim":61.0, @@ -24605,14 +24627,6 @@ "sim":61.0, "partner":"2khw" }, - { - "sim":60.0, - "partner":"2ju6" - }, - { - "sim":60.0, - "partner":"2kwd" - }, { "sim":60.0, "partner":"2k0p" @@ -24639,11 +24653,15 @@ }, { "sim":60.0, - "partner":"1fd6" + "partner":"2kwd" }, { "sim":60.0, - "partner":"2igh" + "partner":"2ju6" + }, + { + "sim":60.0, + "partner":"1fd6" }, { "sim":60.0, @@ -24658,12 +24676,12 @@ "partner":"2igd" }, { - "sim":59.0, - "partner":"2plp" + "sim":60.0, + "partner":"2igh" }, { "sim":59.0, - "partner":"2klk" + "partner":"2plp" }, { "sim":59.0, @@ -24677,6 +24695,10 @@ "sim":59.0, "partner":"2rmm" }, + { + "sim":59.0, + "partner":"2klk" + }, { "sim":58.0, "partner":"2nmq" @@ -24829,102 +24851,102 @@ ], "subtitle":"Solution nmr structure of de novo designed protein, if3-like fold, northeast structural genomics consortium target or135 (casd target)", "tags":[ - "structural genomics", - "protein structure initiative", "de novo protein", "psi-biology", - "northeast structural genomics consortium (nesg)" + "structural genomics", + "northeast structural genomics consortium (nesg)", + "protein structure initiative" ], "keywords":[ - "evolution", - "ordered", - "monomeric", - "results", - "selection", - "strained", - "designed", - "example", - "provide", - "local", - "heteropolymers", - "target", - "features", - "based", - "sequences", - "interactions", + "engineering", "adopt", - "designing", - "structure", - "minimal", - "consistent", - "relating", - "neutral", - "proteins", - "models", - "drift", - "unique", - "random", - "landscapes", - "evolutionary", - "folded", - "arise", - "structures", - "kinked", - "complicated", - "buried", - "unfavourable", - "foundation", - "natural", - "solution", - "tertiary", - "function", - "motifs", - "nearly", - "rules", + "strained", "free", - "generation", - "loops", - "functional", + "results", + "new", + "make", + "folding", + "protein", "topologies", - "bulged", - "engineering", - "design", + "unfavourable", + "guided", "energetically", + "motifs", "secondary", - "describe", - "stabilized", + "stable", + "rules", "encoded", + "tertiary", + "illuminate", + "relating", + "nearly", + "ideal", + "drift", "biological", - "energy", - "funnels", + "consistent", + "polar", + "buried", + "folded", "completely", - "predicted", - "guided", - "make", - "consisting", - "designs", - "groups", - "patterns", "approach", - "stable", - "fold", - "different", + "proteins", "found", - "leading", - "illuminate", - "state", - "polar", - "ideal", + "evolution", + "features", + "computational", "set", - "protein", + "local", + "designing", + "design", + "energy", + "selection", + "bulged", + "heteropolymers", + "loops", + "natural", + "functional", + "possible", + "different", + "arise", + "consisting", + "fold", + "groups", + "leading", + "solution", + "foundation", + "complicated", + "predicted", "identical", - "understanding", - "computational", + "unique", + "describe", + "minimal", + "funnels", + "landscapes", + "evolutionary", + "designed", + "example", + "models", + "generation", + "sequences", "unlike", - "folding", - "possible", - "five", - "new" + "structures", + "based", + "structure", + "monomeric", + "provide", + "target", + "interactions", + "state", + "patterns", + "function", + "understanding", + "random", + "neutral", + "designs", + "ordered", + "stabilized", + "kinked", + "five" ], "release_date":"2012-02-15", "publication":"\"Principles for designing ideal protein structures\", Nature, 491, 222-227", @@ -25054,11 +25076,11 @@ ], "subtitle":"Solution nmr structure of de novo designed protein, pfk fold, northeast structural genomics consortium target or134", "tags":[ - "structural genomics", - "protein structure initiative", "de novo protein", "psi-biology", - "northeast structural genomics consortium (nesg)" + "structural genomics", + "northeast structural genomics consortium (nesg)", + "protein structure initiative" ], "keywords":[ "description", @@ -25115,11 +25137,11 @@ }, { "sim":51.0, - "partner":"2lrh" + "partner":"2lci" }, { "sim":51.0, - "partner":"2lci" + "partner":"2lrh" } ], "seq_thr_sim_natural":[ @@ -25206,73 +25228,73 @@ ], "subtitle":"Shb peptide structure bound to negatively charged lipid-bilayer after molecular dynamics refinement", "tags":[ - "de novo-peptide", "de novo protein", "potassium channel", + "de novo-peptide", "n-type inactivation" ], "keywords":[ - "accuracy", - "classical", - "rapid", "supramolecular", - "k", - "poses", + "simulations", "molecular", - "topology", - "alone", - "channels", - "membrane", - "associated", - "approach", - "transduction", - "study", - "resolution", - "challenge", - "elemental", - "determining", - "peptide", - "determination", "negatively", - "method", + "dynamic", + "structural", + "either", + "resolution", + "classical", + "topology", "spectroscopy", - "interplay", - "focuses", - "functions", - "difficult", - "simulations", "methods", - "shaker", - "arrangements", - "determined", - "ball", - "obtain", - "domains", - "atomistic", - "iterative", - "dynamics", - "significant", - "b", - "dynamic", - "lipid", + "poses", + "focuses", + "biology", + "determination", + "environment", + "biological", + "structure", "introduce", + "level", "bilayers", - "charged", + "determined", + "transduction", + "functions", "nmr", - "structure", - "representative", + "study", "inactivating", "signal", - "environment", - "biological", - "biology", - "combines", - "either", - "spinning", + "membrane", + "approach", + "determining", + "lipid", + "representative", + "accuracy", + "rapid", + "interplay", + "charged", + "elemental", + "b", + "domains", "polypeptides", + "channels", "systems", - "structural", - "level" + "difficult", + "ball", + "combines", + "k", + "arrangements", + "challenge", + "iterative", + "atomistic", + "method", + "spinning", + "alone", + "shaker", + "associated", + "peptide", + "dynamics", + "obtain", + "significant" ], "release_date":"2012-08-08", "publication":"\"Supramolecular structure of membrane-associated polypeptides by combining solid-state NMR and molecular dynamics simulations\", Biophys.J., 103, 29-37", @@ -25374,106 +25396,106 @@ ], "subtitle":"Structural characterization of an lpa1 second extracellular loop mimetic with a self-assembling coiled-coil folding constraint", "tags":[ - "g protein-coupled receptor", "de novo protein", - "gpcr" + "gpcr", + "g protein-coupled receptor" ], "keywords":[ - "deformation", - "studies", - "combined", - "peptide", - "receptor", - "near", - "robust", - "crystal", - "el2", + "affinity", + "demonstrates", "limited", - "interacted", + "structural", + "development", + "number", "show", - "based", - "bear", - "connecting", - "structure", + "trends", + "extracellular", + "transduction", + "folding", + "model", "docking", - "affinity", - "therapeutic", - "consistent", - "intrinsic", - "seven", - "without", - "antagonist", - "models", - "involved", - "tools", - "number", - "resulting", - "demonstrates", - "yet", - "gpcr", - "assemble", - "structures", + "study", "showed", - "signal", - "constraint", - "transmembrane", - "second", + "conclusively", + "domains", + "intrinsic", "lpa", - "previously", - "demonstrated", "expected", - "loops", - "additionally", - "identity", - "transduction", - "embedded", - "1", - "interest", - "growing", + "two", + "crystal", + "helices", + "involved", + "prior", "g", - "conclusively", - "model", "using", - "nmr", - "noticeable", - "extracellular", - "sequence", - "served", + "deformation", + "robust", + "receptor", + "el", + "formed", + "interest", + "connecting", + "variability", + "due", "biological", - "known", - "ensemble", - "tremendous", - "structural", - "one", - "helices", - "prior", - "study", - "contrast", - "hybrid", - "experiments", - "means", - "understand", - "discovery", - "different", + "relative", "residues", + "bear", + "combined", + "el2", + "growing", + "constraint", + "ensemble", + "computational", + "tools", "characterize", - "two", - "due", + "peptide", + "1", + "mutagenesis", + "identity", + "noticeable", + "loops", + "yet", + "resolved", + "different", + "antagonist", + "experiments", + "therapeutic", + "embedded", + "served", "validated", - "domains", - "development", - "trends", + "contrast", + "sequence", + "demonstrated", + "near", + "hybrid", "evaluated", - "nine", - "computational", - "variability", - "folding", - "relative", - "formed", + "models", + "one", + "tremendous", + "transmembrane", "loop", - "mutagenesis", - "resolved", - "el" + "structures", + "understand", + "previously", + "based", + "without", + "structure", + "nine", + "resulting", + "additionally", + "nmr", + "means", + "signal", + "known", + "seven", + "gpcr", + "discovery", + "interacted", + "studies", + "assemble", + "second", + "consistent" ], "release_date":"2013-01-09", "publication":"\"Structural Characterization of an LPA1 Second Extracellular Loop Mimetic with a Self-Assembling Coiled-Coil Folding Constraint\", Int J Mol Sci, 14, 2788-2807", @@ -25601,11 +25623,11 @@ ], "subtitle":"Solution nmr structure of de novo designed protein, p-loop ntpase fold, northeast structural genomics consortium target or136", "tags":[ - "northeast structural genomics consortium", - "structural genomics", "protein structure initiative", - "de novo protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", + "structural genomics", "psi-biology" ], "keywords":[ @@ -25675,11 +25697,11 @@ }, { "sim":58.0, - "partner":"2kpo" + "partner":"2lv8" }, { "sim":58.0, - "partner":"2lv8" + "partner":"2kpo" } ], "seq_thr_sim_natural":[ @@ -25755,78 +25777,78 @@ "z domain" ], "keywords":[ - "great", - "sites", - "utilize", + "affinity", + "designed", + "complex", + "engineering", + "luminescence", + "dynamic", + "however", "many", - "demonstrated", - "nm", - "magnetic", - "proteins", - "represents", - "spectra", - "helices", + "structural", + "metal", "redesigned", - "use", - "imaging", - "report", + "chimeric", "igg", - "130", - "produce", - "ions", - "metal", - "challenge", - "paramagnetic", - "offer", - "immunoglobulin", - "determining", - "place", - "luminescence", - "designed", "spectroscopy", - "illustrated", + "loop", + "reagent", "interest", - "distribution", - "shown", - "two", - "nuclear", - "motif", - "optical", - "engineering", - "potential", "include", - "lanthanide", + "distribution", + "represents", + "produce", + "130", "furthermore", + "imaging", + "potential", + "nm", + "great", + "report", + "place", + "spectra", "model", - "characterization", - "significant", - "investigations", - "bound", - "microscopy", + "preliminary", + "nmr", + "lanthanide", + "ion", + "magnetic", "protein", "bind", - "dynamic", + "shown", "positions", - "complex", - "nmr", + "bound", + "proteins", + "sites", + "binding", "solution", - "preliminary", - "resonance", + "determining", + "utility", + "motif", + "characterization", + "ions", + "microscopy", + "use", + "investigations", + "illustrated", "native", - "reagent", - "effects", + "resonance", + "demonstrated", "retaining", - "utility", - "however", - "chimeric", - "affinity", "fc", + "immunoglobulin", + "two", + "nuclear", + "offer", + "paramagnetic", + "helices", + "effects", + "challenge", + "glycan", + "optical", + "utilize", "novel", - "binding", - "structural", - "loop", - "ion", - "glycan" + "significant" ], "release_date":"2012-09-12", "publication":"\"Lanthanide binding and IgG affinity construct: Potential applications in solution NMR, MRI, and luminescence microscopy\", Protein Sci., 21, 1456-1466", @@ -25868,10 +25890,6 @@ "sim":104.0, "partner":"8ut0" }, - { - "sim":100.0, - "partner":"2spz" - }, { "sim":100.0, "partner":"1q2n" @@ -25884,6 +25902,10 @@ "sim":100.0, "partner":"1h0t" }, + { + "sim":100.0, + "partner":"2spz" + }, { "sim":98.0, "partner":"2jwd" @@ -25934,11 +25956,11 @@ }, { "sim":74.0, - "partner":"2b88" + "partner":"2b87" }, { "sim":74.0, - "partner":"2b87" + "partner":"2b88" }, { "sim":74.0, @@ -26067,11 +26089,11 @@ ], "subtitle":"Solution nmr structure of de novo designed protein, p-loop ntpase fold, northeast structural genomics consortium target or137", "tags":[ - "northeast structural genomics consortium", - "structural genomics", "protein structure initiative", - "de novo protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", + "structural genomics", "psi-biology" ], "keywords":[ @@ -26133,11 +26155,11 @@ }, { "sim":59.0, - "partner":"2kpo" + "partner":"2lv8" }, { "sim":59.0, - "partner":"2lv8" + "partner":"2kpo" }, { "sim":57.0, @@ -26232,11 +26254,11 @@ ], "subtitle":"Solution nmr structure of de novo designed four helix bundle protein, northeast structural genomics consortium (nesg) target or188", "tags":[ - "northeast structural genomics consortium", - "structural genomics", "protein structure initiative", - "de novo protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", + "structural genomics", "psi-biology" ], "keywords":[ @@ -26354,103 +26376,103 @@ ], "subtitle":"Solution nmr structure of de novo designed protein, rossmann 3x1 fold, northeast structural genomics consortium target or157", "tags":[ - "northeast structural genomics consortium", - "structural genomics", "protein structure initiative", - "de novo protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", + "structural genomics", "psi-biology" ], "keywords":[ - "evolution", - "ordered", - "monomeric", - "results", - "selection", - "strained", - "designed", - "example", - "provide", - "local", - "heteropolymers", - "target", - "features", - "based", - "sequences", - "interactions", + "engineering", "adopt", - "designing", - "structure", - "minimal", - "consistent", - "relating", - "neutral", - "proteins", - "models", - "drift", - "unique", - "random", - "landscapes", - "evolutionary", - "folded", - "arise", - "structures", - "kinked", - "complicated", - "buried", - "unfavourable", - "foundation", - "natural", - "solution", - "tertiary", - "function", - "motifs", - "nearly", - "rules", + "strained", "free", - "generation", - "loops", - "functional", + "results", + "new", + "make", + "folding", + "protein", "topologies", - "bulged", - "engineering", - "design", + "unfavourable", + "guided", "energetically", + "motifs", "secondary", - "describe", - "stabilized", + "stable", + "rules", "encoded", + "tertiary", + "illuminate", + "relating", + "nearly", + "ideal", + "drift", "biological", - "energy", - "funnels", + "consistent", + "polar", + "buried", + "folded", "completely", - "predicted", - "guided", - "make", - "consisting", - "designs", - "groups", - "patterns", "approach", - "stable", - "fold", - "different", + "proteins", "found", - "leading", - "illuminate", - "state", - "polar", - "ideal", + "evolution", + "features", + "computational", "set", - "protein", + "local", + "designing", + "design", + "energy", + "selection", + "bulged", + "heteropolymers", + "loops", + "natural", + "functional", + "possible", + "different", + "arise", + "consisting", + "fold", + "groups", + "leading", + "solution", + "foundation", + "complicated", + "predicted", "identical", - "understanding", - "computational", + "unique", + "describe", + "minimal", + "funnels", + "landscapes", + "evolutionary", + "designed", + "example", + "models", + "generation", + "sequences", "unlike", - "folding", - "possible", - "five", - "new" + "structures", + "based", + "structure", + "monomeric", + "provide", + "target", + "interactions", + "state", + "patterns", + "function", + "understanding", + "random", + "neutral", + "designs", + "ordered", + "stabilized", + "kinked", + "five" ], "release_date":"2012-06-13", "publication":"\"Principles for designing ideal protein structures\", Nature, 491, 222-227", @@ -26564,102 +26586,102 @@ ], "subtitle":"Solution nmr structure de novo designed rossmann 2x2 fold protein, northeast structural genomics consortium (nesg) target or16", "tags":[ - "structural genomics", - "protein structure initiative", "de novo protein", "psi-biology", - "northeast structural genomics consortium (nesg)" + "structural genomics", + "northeast structural genomics consortium (nesg)", + "protein structure initiative" ], "keywords":[ - "evolution", - "ordered", - "monomeric", - "results", - "selection", - "strained", - "designed", - "example", - "provide", - "local", - "heteropolymers", - "target", - "features", - "based", - "sequences", - "interactions", + "engineering", "adopt", - "designing", - "structure", - "minimal", - "consistent", - "relating", - "neutral", - "proteins", - "models", - "drift", - "unique", - "random", - "landscapes", - "evolutionary", - "folded", - "arise", - "structures", - "kinked", - "complicated", - "buried", - "unfavourable", - "foundation", - "natural", - "solution", - "tertiary", - "function", - "motifs", - "nearly", - "rules", + "strained", "free", - "generation", - "loops", - "functional", + "results", + "new", + "make", + "folding", + "protein", "topologies", - "bulged", - "engineering", - "design", + "unfavourable", + "guided", "energetically", + "motifs", "secondary", - "describe", - "stabilized", + "stable", + "rules", "encoded", + "tertiary", + "illuminate", + "relating", + "nearly", + "ideal", + "drift", "biological", - "energy", - "funnels", + "consistent", + "polar", + "buried", + "folded", "completely", - "predicted", - "guided", - "make", - "consisting", - "designs", - "groups", - "patterns", "approach", - "stable", - "fold", - "different", + "proteins", "found", - "leading", - "illuminate", - "state", - "polar", - "ideal", + "evolution", + "features", + "computational", "set", - "protein", + "local", + "designing", + "design", + "energy", + "selection", + "bulged", + "heteropolymers", + "loops", + "natural", + "functional", + "possible", + "different", + "arise", + "consisting", + "fold", + "groups", + "leading", + "solution", + "foundation", + "complicated", + "predicted", "identical", - "understanding", - "computational", + "unique", + "describe", + "minimal", + "funnels", + "landscapes", + "evolutionary", + "designed", + "example", + "models", + "generation", + "sequences", "unlike", - "folding", - "possible", - "five", - "new" + "structures", + "based", + "structure", + "monomeric", + "provide", + "target", + "interactions", + "state", + "patterns", + "function", + "understanding", + "random", + "neutral", + "designs", + "ordered", + "stabilized", + "kinked", + "five" ], "release_date":"2012-08-08", "publication":"\"Principles for designing ideal protein structures\", Nature, 491, 222-227", @@ -26824,102 +26846,102 @@ ], "subtitle":"Solution nmr structure de novo designed pfk fold protein, northeast structural genomics consortium (nesg) target or250", "tags":[ - "structural genomics", - "protein structure initiative", "de novo protein", "psi-biology", - "northeast structural genomics consortium (nesg)" + "structural genomics", + "northeast structural genomics consortium (nesg)", + "protein structure initiative" ], "keywords":[ - "evolution", - "ordered", - "monomeric", - "results", - "selection", - "strained", - "designed", - "example", - "provide", - "local", - "heteropolymers", - "target", - "features", - "based", - "sequences", - "interactions", + "engineering", "adopt", - "designing", - "structure", - "minimal", - "consistent", - "relating", - "neutral", - "proteins", - "models", - "drift", - "unique", - "random", - "landscapes", - "evolutionary", - "folded", - "arise", - "structures", - "kinked", - "complicated", - "buried", - "unfavourable", - "foundation", - "natural", - "solution", - "tertiary", - "function", - "motifs", - "nearly", - "rules", + "strained", "free", - "generation", - "loops", - "functional", + "results", + "new", + "make", + "folding", + "protein", "topologies", - "bulged", - "engineering", - "design", + "unfavourable", + "guided", "energetically", + "motifs", "secondary", - "describe", - "stabilized", + "stable", + "rules", "encoded", + "tertiary", + "illuminate", + "relating", + "nearly", + "ideal", + "drift", "biological", - "energy", - "funnels", + "consistent", + "polar", + "buried", + "folded", "completely", - "predicted", - "guided", - "make", - "consisting", - "designs", - "groups", - "patterns", "approach", - "stable", - "fold", - "different", + "proteins", "found", - "leading", - "illuminate", - "state", - "polar", - "ideal", + "evolution", + "features", + "computational", "set", - "protein", + "local", + "designing", + "design", + "energy", + "selection", + "bulged", + "heteropolymers", + "loops", + "natural", + "functional", + "possible", + "different", + "arise", + "consisting", + "fold", + "groups", + "leading", + "solution", + "foundation", + "complicated", + "predicted", "identical", - "understanding", - "computational", + "unique", + "describe", + "minimal", + "funnels", + "landscapes", + "evolutionary", + "designed", + "example", + "models", + "generation", + "sequences", "unlike", - "folding", - "possible", - "five", - "new" + "structures", + "based", + "structure", + "monomeric", + "provide", + "target", + "interactions", + "state", + "patterns", + "function", + "understanding", + "random", + "neutral", + "designs", + "ordered", + "stabilized", + "kinked", + "five" ], "release_date":"2012-08-08", "publication":"\"Principles for designing ideal protein structures\", Nature, 491, 222-227", @@ -26976,11 +26998,11 @@ }, { "sim":51.0, - "partner":"2lrh" + "partner":"2lci" }, { "sim":51.0, - "partner":"2lci" + "partner":"2lrh" } ], "seq_thr_sim_natural":[ @@ -27055,96 +27077,96 @@ ], "subtitle":"Identification of the structural traits mediating the antimicrobial activity of a chimeric peptide of hbd2 and hbd3", "tags":[ - "antimicrobial peptide", "designer peptide", - "antimicrobial protein, de novo protein", + "antimicrobial protein", "de novo protein", - "antimicrobial protein" + "antimicrobial peptide", + "antimicrobial protein, de novo protein" ], "keywords":[ - "many", - "represents", - "defence", - "peptide", + "escherichia", + "molecular", + "role", + "structural", "candidate", - "broad", - "determined", - "features", "show", - "order", - "basis", - "regions", + "c3", + "new", "exceptional", - "similarity", - "structure", - "allowed", - "escherichia", - "however", - "even", - "direct", - "identification", - "killed", + "activities", + "six", + "immunity", + "mediate", + "two", + "line", + "participate", "similar", + "tertiary", + "however", + "hbd3", + "divergent", + "due", + "represents", "family", + "led", "antibiotics", - "killing", - "published", - "hbd3", - "innate", + "basis", "staphylococcus", - "efficiency", - "chimera", - "structures", - "pivotal", - "tertiary", - "aureus", + "published", + "broad", + "killing", + "higher", "organisms", - "compared", - "first", - "role", - "molecules", - "properties", + "features", + "substantial", + "regions", + "peptide", "investigate", - "immunity", - "plays", - "generation", - "molecular", + "direct", "identity", - "higher", + "compared", + "spectroscopy", + "even", + "properties", + "humans", + "pathogens", "coli", - "antimicrobial", - "substantial", - "class", - "activities", - "divergent", - "activity", - "hbd2", - "six", - "comparison", - "c3", - "nmr", "promising", "sequence", - "kills", - "mediate", - "structural", - "led", + "peptides", + "killed", + "whereas", + "antimicrobial", + "spectrum", + "generation", + "order", + "many", "one", - "line", - "participate", - "human", + "hbd2", + "identification", + "structures", "efficacy", - "peptides", - "pathogens", - "humans", - "spectroscopy", - "two", - "due", + "first", + "allowed", + "structure", + "determined", + "kills", + "nmr", + "defence", + "plays", + "class", + "molecules", + "innate", "chimeras", + "activity", "distinct", - "spectrum", - "new", - "whereas" + "efficiency", + "chimera", + "human", + "similarity", + "aureus", + "pivotal", + "comparison" ], "release_date":"2013-08-14", "publication":"\"Identification of structural traits that increase the antimicrobial activity of a chimeric peptide of human beta-defensins 2 and 3\", Biochem.Biophys.Res.Commun., 427, 207-211", @@ -27291,48 +27313,48 @@ "ligase" ], "keywords":[ - "noncatalytic", - "evolution", - "original", + "flexibility", + "engineering", + "directed", + "design", + "enhanced", "ligase", - "functional", - "entirely", "conformational", - "chemical", + "starting", + "functional", + "suitable", "rna", - "challenge", + "enzymatic", + "structure", + "fold", "scaffolds", - "directed", + "new", + "recently", + "adopted", + "protein", + "carry", + "primordial", + "function", + "vitro", + "capable", "artificial", - "fold", + "lost", + "entirely", + "noncatalytic", + "scaffold", "enzyme", + "generated", "substantially", "sufficient", - "carry", "carrying", - "enzymatic", - "generated", - "lost", - "demonstrating", - "capable", - "flexibility", - "engineering", - "vitro", - "scaffold", - "design", - "dynamics", - "protein", - "enhanced", - "primordial", - "structure", - "function", - "suitable", - "recently", "major", - "adopted", + "original", + "evolution", + "chemical", + "challenge", + "demonstrating", "catalysis", - "starting", - "new" + "dynamics" ], "release_date":"2012-10-24", "publication":"\"Structure and dynamics of a primordial catalytic fold generated by in vitro evolution\", Nat.Chem.Biol., 9, 81-83", @@ -27469,11 +27491,11 @@ ], "subtitle":"Solution nmr structure of de novo designed top7 fold protein top7m13, northeast structural genomics consortium (nesg) target or33", "tags":[ - "structural genomics", - "protein structure initiative", "de novo protein", "psi-biology", - "northeast structural genomics consortium (nesg)" + "structural genomics", + "northeast structural genomics consortium (nesg)", + "protein structure initiative" ], "keywords":[ "description", @@ -27514,11 +27536,11 @@ }, { "sim":118.0, - "partner":"2n4e" + "partner":"2n41" }, { "sim":118.0, - "partner":"2n41" + "partner":"2n4e" }, { "sim":94.0, @@ -27638,11 +27660,11 @@ ], "subtitle":"Solution nmr structure of de novo designed top7 fold protein top7m13, northeast structural genomics consortium (nesg) target or33", "tags":[ - "structural genomics", - "protein structure initiative", "de novo protein", "psi-biology", - "northeast structural genomics consortium (nesg)" + "structural genomics", + "northeast structural genomics consortium (nesg)", + "protein structure initiative" ], "keywords":[ "description", @@ -27683,11 +27705,11 @@ }, { "sim":118.0, - "partner":"2n4e" + "partner":"2n41" }, { "sim":118.0, - "partner":"2n41" + "partner":"2n4e" }, { "sim":94.0, @@ -27767,10 +27789,10 @@ ], "subtitle":"Nmr structure of beta alpha alpha 38", "tags":[ - "miniprotein", - "rhh1 superfamily", "de novo protein", - "hub-linked" + "rhh1 superfamily", + "hub-linked", + "miniprotein" ], "keywords":[ "description", @@ -27872,10 +27894,10 @@ ], "subtitle":"Nmr structure of a strand-swapped dimer of the ww domain", "tags":[ - "miniprotein", - "disulfide", "de novo protein", - "hub-linked" + "disulfide", + "hub-linked", + "miniprotein" ], "keywords":[ "description", @@ -27989,119 +28011,119 @@ ], "subtitle":"Solution nmr structure of alpha3y", "tags":[ - "tyrosine radical", - "three-helix bundle", - "proton-coupled electron transfer", "redox protein", - "de novo protein" + "proton-coupled electron transfer", + "tyrosine radical", + "de novo protein", + "three-helix bundle" ], "keywords":[ - "analysis", - "characteristics", - "photochemical", - "use", - "\u03b13y", - "suggest", - "concentration", - "kinetics", - "generated", - "oxidant", - "stepwise", - "static", - "contains", - "ii", - "proton", - "structure", - "decays", - "fluorescence", - "decay", - "reactive", + "finally", + "kinetic", + "rate", + "role", + "structural", + "ru", + "dityrosine", + "explain", + "via", + "tyrosine", + "residue", + "spectra", + "model", + "protein", + "ph", "5", + "controlling", + "electron", + "dimerization", + "proton", + "together", + "essential", + "site", + "stepwise", + "reversibly", + "come", + "two", "k", - "pd", - "slowly", + "10", + "oxidant", + "using", + "released", "play", - "presented", - "h", - "enzymes", - "pcet", - "finally", - "effectively", - "3", - "controlling", - "upon", + "phenolic", + "photochemical", + "controlled", "dynamic", + "soluble", + "respectively", + "pcet", + "relative", + "pd", "buried", - "versus", - "solution", - "dityrosine", - "involves", - "essential", - "released", - "form", - "measurements", - "ru", - "discussed", - "come", - "role", - "properties", "stability", - "data", - "concerted", - "reversibly", - "reveals", - "spectra", - "via", - "respectively", - "phenolic", - "4", + "y32", + "kinetics", + "concentration", + "use", + "enzymes", "may", - "10", + "contains", + "suggest", + "ensemble", + "slowly", + "oxidation", + "\u03b13y", + "measurements", "redox", - "shown", - "transfer", - "rate", + "spectroscopy", "provides", - "tyrosine", - "model", - "reduced", - "soluble", - "using", + "properties", + "removed", + "decays", "absorption", - "nmr", - "high", - "constant", + "shown", + "reduced", + "solution", + "radical", + "upon", + "reveals", + "reactive", "kpcet", - "ph", - "kinetic", - "ensemble", - "structural", - "dimerization", + "effectively", + "versus", + "concerted", "range", - "observations", - "cofactor", - "isotope", - "together", - "electron", - "controlled", - "spectroscopy", - "oxidation", - "two", - "state", + "decay", "mechanism", - "explain", - "protein", - "residue", - "yield", - "removed", - "y32", + "cofactor", + "characteristics", "deeply", + "fluorescence", + "form", + "analysis", + "involves", + "h", "dependent", - "radical", "oxidized", - "relative", - "site", - "voltammetry" + "static", + "3", + "structure", + "isotope", + "nmr", + "state", + "yield", + "4", + "presented", + "high", + "discussed", + "generated", + "constant", + "data", + "voltammetry", + "observations", + "transfer", + "ii" ], "release_date":"2014-08-20", "publication":"\"Photochemical tyrosine oxidation in the structurally well-defined alpha 3Y protein: proton-coupled electron transfer and a long-lived tyrosine radical\", J.Am.Chem.Soc., 136, 14039-14051", @@ -28217,79 +28239,79 @@ ], "subtitle":"Nmr solution structure of a computational designed protein based on template of human erythrocytic ubiquitin", "tags":[ - "ubiquitin", "de novo protein", "protein design", - "statistical energy function" + "statistical energy function", + "ubiquitin" ], "keywords":[ + "designed", "verified", - "statistical", - "general", - "foldability", - "excellent", - "rival", - "efficiently", "improve", - "amino", - "models", - "proteins", - "solved", "reach", - "comprehensive", - "approach", - "report", - "de", - "novo", - "strategy", - "verify", - "four", - "way", - "acid", - "desired", - "experimental", - "fold", - "tools", - "designed", - "limitations", - "different", - "used", - "supply", - "provide", - "noteworthy", - "current", - "notwithstanding", - "two", - "agreement", - "methods", - "experimentally", "engineering", + "models", "design", - "encode", "sequences", - "complement", + "energy", + "way", + "foldability", "overcome", - "significant", + "methods", + "ones", + "current", "structures", - "protein", - "feedbacks", + "de", + "experimental", + "used", + "agreement", + "verify", + "experimentally", + "different", + "thorough", + "efficiently", + "respective", + "comprehensive", + "acid", + "fold", + "report", + "provide", "assess", + "new", "targets", - "respective", - "theory", - "breakthroughs", + "strategy", + "complement", + "noteworthy", + "statistical", + "protein", + "amino", + "understanding", "function", - "establish", + "approach", + "proteins", + "develop", "solution", + "extensive", + "novo", + "general", + "supply", "needs", - "energy", - "understanding", + "solved", + "excellent", + "encode", + "two", + "rival", + "breakthroughs", + "establish", + "limitations", + "theory", + "four", + "desired", "computational", - "extensive", - "thorough", - "ones", - "new", - "develop" + "feedbacks", + "tools", + "notwithstanding", + "significant" ], "release_date":"2014-10-29", "publication":"\"Protein design with a comprehensive statistical energy function and boosted by experimental selection for foldability\", Nat Commun, 5, 5330-5330", @@ -28410,80 +28432,80 @@ ], "subtitle":"Nmr solution structure of a computational designed protein based on structure template 1cy5", "tags":[ - "protein evolution", "de novo protein", - "protein design", + "alpha-helical greek", "statistical energy function", - "alpha-helical greek" + "protein design", + "protein evolution" ], "keywords":[ + "designed", "verified", - "statistical", - "general", - "foldability", - "excellent", - "rival", - "efficiently", "improve", - "amino", - "models", - "proteins", - "solved", "reach", - "comprehensive", - "approach", - "report", - "de", - "novo", - "strategy", - "verify", - "four", - "way", - "acid", - "desired", - "experimental", - "fold", - "tools", - "designed", - "limitations", - "different", - "used", - "supply", - "provide", - "noteworthy", - "current", - "notwithstanding", - "two", - "agreement", - "methods", - "experimentally", "engineering", + "models", "design", - "encode", "sequences", - "complement", + "energy", + "way", + "foldability", "overcome", - "significant", + "methods", + "ones", + "current", "structures", - "protein", - "feedbacks", + "de", + "experimental", + "used", + "agreement", + "verify", + "experimentally", + "different", + "thorough", + "efficiently", + "respective", + "comprehensive", + "acid", + "fold", + "report", + "provide", "assess", + "new", "targets", - "respective", - "theory", - "breakthroughs", + "strategy", + "complement", + "noteworthy", + "statistical", + "protein", + "amino", + "understanding", "function", - "establish", + "approach", + "proteins", + "develop", "solution", + "extensive", + "novo", + "general", + "supply", "needs", - "energy", - "understanding", + "solved", + "excellent", + "encode", + "two", + "rival", + "breakthroughs", + "establish", + "limitations", + "theory", + "four", + "desired", "computational", - "extensive", - "thorough", - "ones", - "new", - "develop" + "feedbacks", + "tools", + "notwithstanding", + "significant" ], "release_date":"2014-10-29", "publication":"\"Protein design with a comprehensive statistical energy function and boosted by experimental selection for foldability\", Nat Commun, 5, 5330-5330", @@ -28600,90 +28622,90 @@ ], "subtitle":"Solution nmr structure of de novo designed protein lfr1 1 with ferredoxin fold, northeast structural genomics consortium (nesg) target or414", "tags":[ - "northeast structural genomics consortium", - "structural genomics", "protein structure initiative", - "de novo protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", + "structural genomics", "psi-biology" ], "keywords":[ - "series", - "loop", - "general", - "control", - "demonstrate", - "codependencies", - "considerable", - "overall", + "tertiary", + "local", + "achieve", + "designed", + "performing", + "designing", + "particular", + "registry", + "design", + "rule", + "nonlocal", + "controlled", + "custom", + "length", "topology", - "proteins", - "patterns", - "systematically", "geometry", - "extended", - "described", - "length", - "four", - "relate", - "topologies", - "elements", + "principles", + "loop", "afforded", - "rule", + "show", + "structures", + "ideal", + "different", + "overall", + "analyzing", + "structure", + "extended", + "within", "fold", - "desired", + "elements", "shape", - "designed", - "enable", - "controlled", - "different", + "angles", + "codependencies", "resulting", - "custom", - "functions", + "relate", + "successive", "provide", - "local", - "two", "precisely", - "folds", - "ideal", - "analyzing", - "set", - "show", - "design", - "foundation", - "linking", - "performing", - "lengths", - "structures", - "protein", - "interactions", - "variation", - "given", - "secondary", - "successive", - "backbone", - "designing", + "functions", + "recently", "nmr", + "interactions", + "protein", + "control", + "lengths", + "topologies", + "patterns", "torsion", - "structure", - "stabilized", - "nonlocal", - "tertiary", - "particular", - "solution", - "motifs", - "size", - "angles", - "recently", - "within", - "principles", - "registry", - "achieve", - "consistent", "completely", + "given", + "proteins", "packing", + "solution", + "foundation", "fine", - "rules" + "size", + "enable", + "described", + "backbone", + "series", + "general", + "considerable", + "demonstrate", + "motifs", + "two", + "folds", + "secondary", + "four", + "rules", + "desired", + "variation", + "linking", + "stabilized", + "systematically", + "set", + "consistent" ], "release_date":"2014-08-20", "publication":"\"Control over overall shape and size in de novo designed proteins\", Proc.Natl.Acad.Sci.USA, 112, E5478-E5485", @@ -28816,11 +28838,11 @@ ], "subtitle":"Solution nmr structure of de novo designed protein, northeast structural genomics consortium (nesg) target or457", "tags":[ - "northeast structural genomics consortium", - "structural genomics", "protein structure initiative", - "de novo protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", + "structural genomics", "psi-biology" ], "keywords":[ @@ -28894,11 +28916,11 @@ }, { "sim":57.0, - "partner":"2kpo" + "partner":"2lv8" }, { "sim":57.0, - "partner":"2lv8" + "partner":"2kpo" }, { "sim":53.0, @@ -29006,11 +29028,11 @@ ], "subtitle":"Solution nmr structure of de novo designed protein, northeast structural genomics consortium (nesg) target or462", "tags":[ - "northeast structural genomics consortium", - "structural genomics", "protein structure initiative", - "de novo protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", + "structural genomics", "psi-biology" ], "keywords":[ @@ -29080,11 +29102,11 @@ }, { "sim":56.0, - "partner":"2kpo" + "partner":"2lv8" }, { "sim":56.0, - "partner":"2lv8" + "partner":"2kpo" } ], "seq_thr_sim_natural":[ @@ -29188,11 +29210,11 @@ ], "subtitle":"Solution nmr structure of de novo designed protein, northeast structural genomics consortium (nesg) target or459", "tags":[ - "northeast structural genomics consortium", - "structural genomics", "protein structure initiative", - "de novo protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", + "structural genomics", "psi-biology" ], "keywords":[ @@ -29230,11 +29252,11 @@ "seq_thr_sim_designed":[ { "sim":94.0, - "partner":"2mbl" + "partner":"2mbm" }, { "sim":94.0, - "partner":"2mbm" + "partner":"2mbl" } ], "seq_thr_sim_natural":[ @@ -29248,7 +29270,7 @@ ], "seq_max_sim_designed":{ "sim":94.0, - "partner":"2mbl" + "partner":"2mbm" }, "seq_max_sim_natural":[ @@ -29342,11 +29364,11 @@ ], "subtitle":"Solution nmr structure of de novo designed fr55, northeast structural genomics consortium (nesg) target or109", "tags":[ - "northeast structural genomics consortium", - "structural genomics", "protein structure initiative", - "de novo protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", + "structural genomics", "psi-biology" ], "keywords":[ @@ -29527,88 +29549,88 @@ ], "subtitle":"Non-reducible analogues of alpha-conotoxin rgia: [3,12]-cis dicarba rgia", "tags":[ - "dicarba", - "alpha-conotoxin", - "rgia", + "non-reducible", "de novo protein", - "non-reducible" + "rgia", + "dicarba", + "alpha-conotoxin" ], "keywords":[ - "stability", - "framework", - "antagonist", - "nicotinic", - "subtype", - "replaced", - "channels", - "clinical", - "represents", - "conditions", - "exhibited", - "receptors", - "acetylcholine", - "assessed", - "also", - "nachrs", - "acting", - "pattern", - "inhibitor", - "four", - "bridges", - "human", - "channel", - "nonreducible", - "hek293", + "\u03b19\u03b110", "stably", - "peptide", - "receptor", - "may", - "retained", + "effective", "liability", - "transfected", - "physiological", - "dicarba", - "selectivity", - "activity", "gabab", - "improved", - "determined", - "potential", - "inhibition", - "explore", - "rgia", + "nachr", + "opposite", + "serum", + "reduction", + "currents", + "displayed", + "calcium", + "receptors", "mechanistic", - "effective", + "assessed", + "exhibited", "structures", + "acetylcholine", "synthesized", - "bond", - "reduction", - "applications", + "represent", + "pattern", + "represents", + "antagonist", + "potential", + "biological", + "bridges", + "framework", + "replaced", + "inhibitor", + "determined", + "clinical", "targets", - "selectively", + "also", + "therapeutic", + "expressing", + "rgia", + "explore", "nmr", - "analogues", - "displayed", - "pairs", - "solution", - "represent", + "disulfide", "pain", + "selectivity", + "stability", + "probes", + "improved", + "solution", + "analogues", + "conditions", + "acting", + "nachrs", + "may", + "retained", + "activity", "native", - "biological", - "evaluated", - "serum", - "calcium", - "\u03b19\u03b110", - "nachr", "cells", - "disulfide", - "currents", - "therapeutic", - "opposite", + "selectively", + "dicarba", + "nonreducible", + "channels", + "bond", + "physiological", + "channel", + "hek293", + "applications", + "inhibition", + "subtype", + "whereas", + "evaluated", + "peptide", + "four", + "human", + "transfected", "treatment", - "probes", - "expressing", - "whereas" + "nicotinic", + "pairs", + "receptor" ], "release_date":"2014-11-26", "publication":"\"Dicarba Analogues of alpha-Conotoxin RgIA. Structure, Stability, and Activity at Potential Pain Targets\", J.Med.Chem., 57, 9933-9944", @@ -29736,88 +29758,88 @@ ], "subtitle":"Non-reducible analogues of alpha-conotoxin rgia: [3,12]-trans dicarba rgia", "tags":[ - "dicarba", - "alpha-conotoxin", - "rgia", + "non-reducible", "de novo protein", - "non-reducible" + "rgia", + "dicarba", + "alpha-conotoxin" ], "keywords":[ - "stability", - "framework", - "antagonist", - "nicotinic", - "subtype", - "replaced", - "channels", - "clinical", - "represents", - "conditions", - "exhibited", - "receptors", - "acetylcholine", - "assessed", - "also", - "nachrs", - "acting", - "pattern", - "inhibitor", - "four", - "bridges", - "human", - "channel", - "nonreducible", - "hek293", + "\u03b19\u03b110", "stably", - "peptide", - "receptor", - "may", - "retained", + "effective", "liability", - "transfected", - "physiological", - "dicarba", - "selectivity", - "activity", "gabab", - "improved", - "determined", - "potential", - "inhibition", - "explore", - "rgia", + "nachr", + "opposite", + "serum", + "reduction", + "currents", + "displayed", + "calcium", + "receptors", "mechanistic", - "effective", + "assessed", + "exhibited", "structures", + "acetylcholine", "synthesized", - "bond", - "reduction", - "applications", + "represent", + "pattern", + "represents", + "antagonist", + "potential", + "biological", + "bridges", + "framework", + "replaced", + "inhibitor", + "determined", + "clinical", "targets", - "selectively", + "also", + "therapeutic", + "expressing", + "rgia", + "explore", "nmr", - "analogues", - "displayed", - "pairs", - "solution", - "represent", + "disulfide", "pain", + "selectivity", + "stability", + "probes", + "improved", + "solution", + "analogues", + "conditions", + "acting", + "nachrs", + "may", + "retained", + "activity", "native", - "biological", - "evaluated", - "serum", - "calcium", - "\u03b19\u03b110", - "nachr", "cells", - "disulfide", - "currents", - "therapeutic", - "opposite", + "selectively", + "dicarba", + "nonreducible", + "channels", + "bond", + "physiological", + "channel", + "hek293", + "applications", + "inhibition", + "subtype", + "whereas", + "evaluated", + "peptide", + "four", + "human", + "transfected", "treatment", - "probes", - "expressing", - "whereas" + "nicotinic", + "pairs", + "receptor" ], "release_date":"2014-11-26", "publication":"\"Dicarba Analogues of alpha-Conotoxin RgIA. Structure, Stability, and Activity at Potential Pain Targets\", J.Med.Chem., 57, 9933-9944", @@ -29938,80 +29960,80 @@ ], "subtitle":"Ssnmr structure of a designed rocker protein", "tags":[ - "de novo desgin", "ssnmr", "de novo protein", - "rocker protein" + "rocker protein", + "de novo desgin" ], "keywords":[ - "conduction", - "sites", - "weakly", - "antiported", - "overall", - "predefined", + "membranes", + "co", "chemistry", + "ca", + "designed", + "cooperativity", + "transports", + "form", + "path", + "individual", + "designing", + "design", + "interacting", + "dynamic", + "metal", + "structural", + "indicate", + "antiported", + "formed", + "principles", + "show", + "biology", "functional", - "membranes", - "membrane", - "proteins", + "flux", + "first", "represents", - "grand", - "magnetic", - "helices", + "overall", + "properties", + "predefined", "report", - "concentration", - "metal", - "challenge", - "ions", - "along", + "conduction", "experiments", + "transition", "crystallography", - "cooperativity", - "designed", + "magnetic", + "bind", + "gradients", + "tightly", + "membrane", "illustrate", - "diffuse", - "interacting", - "interface", - "feasibility", - "two", - "nuclear", "interact", - "flux", - "gradients", - "bundle", - "domains", - "vesicle", - "design", - "show", - "individual", - "helical", - "bind", - "dynamic", - "path", - "negative", + "proteins", + "sites", + "binding", "across", - "designing", "solution", - "pairs", + "helical", + "ions", + "feasibility", + "weakly", + "concentration", + "domains", + "negative", "resonance", + "interface", + "vesicle", + "contain", + "two", + "along", + "nuclear", + "helices", + "challenge", "zn", - "tightly", - "ca", - "biology", - "indicate", + "bundle", + "grand", "protons", - "transition", - "form", - "co", - "principles", - "first", - "transports", - "binding", - "structural", - "formed", - "contain", - "properties" + "pairs", + "diffuse" ], "release_date":"2014-12-24", "publication":"\"De novo design of a transmembrane Zn2+-transporting four-helix bundle\", Science, 346, 1520-1524", @@ -30044,15 +30066,15 @@ "seq_thr_sim_designed":[ { "sim":50.0, - "partner":"4p6j" + "partner":"4p6k" }, { "sim":50.0, - "partner":"4p6l" + "partner":"4p6j" }, { "sim":50.0, - "partner":"4p6k" + "partner":"4p6l" } ], "seq_thr_sim_natural":[ @@ -30077,7 +30099,7 @@ ], "seq_max_sim_designed":{ "sim":50.0, - "partner":"4p6j" + "partner":"4p6k" }, "seq_max_sim_natural":[ @@ -30134,75 +30156,75 @@ "subtitle":"Max1 peptide fibril", "tags":[ "cross-beta", - "biomaterials", "hydrogel", + "protein fibril", + "biomaterials", "designed peptide", - "amyloid-like", - "protein fibril" + "amyloid-like" ], "keywords":[ - "3d", - "layer", + "designed", "supramolecular", - "data", - "syn", - "fibril", + "alternative", + "conformation", + "anti", + "behavior", "molecular", - "propensity", - "network", - "proteins", - "available", + "hairpins", + "characterized", + "hydrogels", + "structural", + "formed", + "show", + "suggests", + "de", + "kinetically", + "represent", "intermolecular", - "use", + "polymorphic", + "likely", + "structure", + "within", + "orientation", "also", - "de", - "novo", "although", - "characterized", - "dictate", - "thermodynamic", - "surprisingly", - "peptide", + "layer", + "monomorphic", + "nmr", + "state", "trapped", + "network", + "interactions", + "propensity", + "proteins", + "layers", "fibrils", - "peptides", - "designed", - "anti", - "polymorphic", + "comprising", + "max1", + "thermodynamic", + "use", + "find", + "networks", "may", + "novo", + "high", + "fidelity", + "adopts", + "dictate", + "available", + "ground", + "peptides", + "apparently", + "fibril", + "3d", + "data", + "assemble", "determine", - "orientation", - "suggests", - "monomorphic", - "behavior", - "state", - "kinetically", + "syn", "arrangements", - "assemble", + "peptide", "fibrillar", - "find", - "ground", - "max1", - "show", - "interactions", - "conformation", - "adopts", - "nmr", - "represent", - "structure", - "high", - "apparently", - "hairpins", - "fidelity", - "networks", - "likely", - "hydrogels", - "within", - "comprising", - "layers", - "alternative", - "structural", - "formed" + "surprisingly" ], "release_date":"2015-07-29", "publication":"\"Molecular structure of monomorphic peptide fibrils within a kinetically trapped hydrogel network\", Proc.Natl.Acad.Sci.USA, 112, 9816-9821", @@ -30335,14 +30357,14 @@ ], "subtitle":"Solution nmr structure of de novo designed protein (fda_60), northeast structural genomics consortium (nesg) target or303", "tags":[ - "structural genomics", "protein structure initiative", - "target or303", - "unknown function, structural genomics", - "psi-biology", "unknown function", + "unknown function, structural genomics", + "structural genomics", "northeast structural genomics consortium (nesg)", - "protein nmr" + "protein nmr", + "target or303", + "psi-biology" ], "keywords":[ "description", @@ -30484,14 +30506,14 @@ ], "subtitle":"Solution nmr structure of de novo designed ferredoxin fold protein sfr3, northeast structural genomics consortium (nesg) target or358", "tags":[ - "structural genomics", "protein structure initiative", - "target or358", - "unknown function, structural genomics", - "psi-biology", "unknown function", + "structural genomics", + "unknown function, structural genomics", + "target or358", "northeast structural genomics consortium (nesg)", - "protein nmr" + "protein nmr", + "psi-biology" ], "keywords":[ "description", @@ -30615,98 +30637,98 @@ ], "subtitle":"Fusion to a highly stable consensus albumin binding domain allows for tunable pharmacokinetics", "tags":[ - "three-helix bundle", + "de novo protein", "albumin binding domain", - "de novo protein" + "three-helix bundle" ], "keywords":[ - "domain", - "results", - "pm", - "studies", - "long", - "link", - "expressed", - "designed", - "mutations", - "11", - "methods", - "determined", - "order", - "precise", - "structure", - "escherichia", "affinity", - "novel", - "consistent", - "molecule", - "called", - "proteins", - "h", - "yielding", - "variants", + "engineering", + "escherichia", "number", - "kda", - "resulting", - "interface", - "cynomolgus", - "highly", + "methods", + "pk", + "results", + "span", + "protein", + "binding", + "terminal", + "yielding", + "demonstrate", + "precise", + "stable", "binds", - "nature", - "solution", - "albumin", - "fusion", + "10", + "epitope", + "using", + "engineered", "abdcon", + "61", + "soluble", "monkey", - "definition", - "consensus", - "properties", + "enabled", "stability", - "fraction", - "coli", - "temperature", - "mapping", - "10", - "61", + "proteins", + "consensus", + "scaffold", + "highly", + "interface", + "tunable", "mice", - "classes", - "engineering", + "cynomolgus", + "long", "bundle", "monkeys", - "design", - "melting", - "mouse", - "60", - "exposure", - "soluble", - "using", - "abd", - "describe", - "high", - "sequence", - "variations", - "serum", - "epitope", - "range", - "demonstrate", - "stable", - "pk", - "human", - "engineered", - "albumins", + "11", + "molecule", "clearance", - "scaffold", - "span", + "design", + "pm", + "classes", + "fusion", "182", + "mapping", + "domain", + "properties", + "called", "explore", - "protein", + "kda", + "solution", + "coli", + "sequence", + "albumin", "levels", - "terminal", + "describe", + "range", + "mouse", + "designed", + "order", + "h", + "five", + "serum", "vivo", - "enabled", - "tunable", - "binding", - "five" + "mutations", + "variants", + "link", + "expressed", + "abd", + "exposure", + "albumins", + "structure", + "determined", + "resulting", + "temperature", + "nature", + "melting", + "high", + "fraction", + "definition", + "60", + "studies", + "human", + "variations", + "novel", + "consistent" ], "release_date":"2015-09-02", "publication":"\"Fusion to a highly stable consensus albumin binding domain allows for tunable pharmacokinetics\", Protein Eng.Des.Sel., 28, 385-393", @@ -30872,14 +30894,14 @@ ], "subtitle":"Solution nmr structure of de novo designed protein, rossmann2x2 fold, northeast structural genomics consortium (nesg) target or446", "tags":[ - "structural genomics", "protein structure initiative", "de novo protein", - "structural genomics, de novo protein", - "psi-biology", "target or446", + "structural genomics", "northeast structural genomics consortium (nesg)", - "protein nmr" + "structural genomics, de novo protein", + "protein nmr", + "psi-biology" ], "keywords":[ "description", @@ -31035,14 +31057,14 @@ ], "subtitle":"Solution nmr structure of de novo designed protein top7nnstycc, northeast structural genomics consortium (nesg) target or34", "tags":[ - "structural genomics", "protein structure initiative", - "de novo protein", "target or34", - "structural genomics, de novo protein", - "psi-biology", + "de novo protein", + "structural genomics", "northeast structural genomics consortium (nesg)", - "protein nmr" + "structural genomics, de novo protein", + "protein nmr", + "psi-biology" ], "keywords":[ "description", @@ -31091,11 +31113,11 @@ }, { "sim":116.0, - "partner":"2mbl" + "partner":"2mbm" }, { "sim":116.0, - "partner":"2mbm" + "partner":"2mbl" } ], "seq_thr_sim_natural":[ @@ -31203,15 +31225,15 @@ ], "subtitle":"Solution nmr structure of de novo designed protein top7nnstycc, northeast structural genomics consortium (nesg) target or34", "tags":[ - "structural genomics", "protein structure initiative", - "de novo protein", "target or34", - "structural genomics, de novo protein", + "de novo protein", "top 7 fold", - "psi-biology", + "structural genomics", "northeast structural genomics consortium (nesg)", - "protein nmr" + "structural genomics, de novo protein", + "protein nmr", + "psi-biology" ], "keywords":[ "description", @@ -31260,11 +31282,11 @@ }, { "sim":116.0, - "partner":"2mbl" + "partner":"2mbm" }, { "sim":116.0, - "partner":"2mbm" + "partner":"2mbl" } ], "seq_thr_sim_natural":[ @@ -31334,56 +31356,56 @@ "de novo protein" ], "keywords":[ - "stability", - "analysis", - "evidence", - "supports", - "magnetic", - "via", - "aqueous", - "spectra", - "stable", + "designed", "whether", - "hypothesis", - "experimental", - "increasing", - "examined", - "among", "cooperativity", - "peptides", - "designed", + "analysis", + "adopt", + "design", "number", - "cd", "spectroscopy", - "may", - "enable", - "documentation", - "two", - "nuclear", - "parallel", - "becomes", "show", - "design", + "experimental", + "first", + "three", + "becomes", + "via", + "increases", + "structure", + "properties", + "among", + "characteristic", + "folding", + "cd", "model", - "comparisons", - "adopt", - "present", - "secondary", + "spectra", + "supports", "nmr", + "documentation", + "magnetic", + "stability", "solution", - "structure", + "evidence", + "enable", + "comparisons", + "may", + "parallel", + "examined", "resonance", - "three", - "circular", - "minimal", - "first", "dichroism", - "folding", - "conformations", "systems", - "increases", - "characteristic", - "properties" + "peptides", + "circular", + "conformations", + "two", + "nuclear", + "present", + "secondary", + "stable", + "aqueous", + "hypothesis", + "increasing", + "minimal" ], "release_date":"2015-10-28", "publication":"\"Impact of Strand Number on Parallel beta-Sheet Stability\", Angew.Chem.Int.Ed.Engl., 54, 14336-14339", @@ -31478,161 +31500,161 @@ ], "subtitle":"Structure of c4vg16krkp", "tags":[ + "lipidated peptide", "de novo protein, antimicrobial protein", - "de novo protein", - "designed antimicrobial peptide", "antimicrobial protein", - "lipidated peptide" + "de novo protein", + "designed antimicrobial peptide" ], "keywords":[ - "neutralisation", - "studies", - "already", - "potent", - "permeabilization", - "issue", - "conserved", - "including", - "lipopolysaccharide", - "peptide", - "designed", - "plant", - "analogue", - "determined", - "obtain", - "interactions", - "enhanced", - "accounts", - "antibacterial", - "therefore", - "structure", + "hemolytic", + "molecular", + "triad", + "leakage", "insights", - "plants", - "health", - "fluorescence", - "pathogen", - "novel", - "therapeutic", - "xanthomonas", - "pv", - "interaction", - "develop", - "chain", - "inflammation", - "membrane", - "demand", - "scavenging", + "development", + "resolution", + "hydrophobic", + "structural", + "organized", + "possessed", + "separation", + "therefore", + "well", "endotoxin", - "face", - "septicemia", - "similar", - "pseudomonas", - "assay", - "entrapped", - "antibiotics", "presence", - "serve", - "lps", - "motif", - "nature", - "separation", - "vesicle", - "alternate", - "solution", - "future", - "antimicrobials", - "constraint", - "dilution", - "either", - "campestris", - "effects", - "anisotropy", - "lipidation", + "lipopolysaccharide", "vg16krkp", - "performed", - "triad", - "previously", - "investigate", - "neutralization", - "quenching", - "elucidate", - "parent", - "possessed", - "control", - "leakage", - "years", - "molecular", - "associated", "via", - "remarkable", - "permeabilisation", - "antimicrobial", - "report", - "coli", - "acyl", - "resolution", - "concern", - "template", + "pseudomonas", + "study", "activities", - "microbroth", - "dye", - "devastating", - "leu11", - "super", - "bond", - "context", - "hydrophobic", - "negative", - "nmr", - "recent", - "high", - "linkage", - "stabilized", - "increase", - "phe12", - "abilities", - "hemolytic", - "gram", - "aeruginosa", - "non", - "conventional", - "structural", + "compactly", + "pathogen", + "disulphide", + "binding", "dimerization", - "susceptible", + "motif", "bacterial", - "trp5", - "rise", - "rising", - "study", - "modified", + "super", + "acyl", + "antibacterial", + "susceptible", + "leu11", + "major", + "two", + "parent", + "recent", "offer", "attractive", + "global", + "effects", + "trp5", + "face", + "accounts", + "similar", + "rise", + "either", + "analogue", + "anisotropy", + "formed", + "neutralisation", + "dye", + "pv", + "level", + "polar", + "antibiotics", + "septicemia", + "control", "npn", - "human", - "pathogens", - "humans", - "peptides", + "become", + "permeabilisation", + "bound", + "develop", + "remarkable", + "constraint", + "neutralization", + "conventional", + "vesicle", + "aeruginosa", + "gram", + "bond", + "campestris", + "future", + "including", + "peptide", + "investigate", + "increase", + "enhanced", + "already", + "context", + "scavenging", "spectroscopy", - "well", + "chain", + "health", + "microbroth", + "lps", + "therapeutic", + "humans", + "template", + "non", + "pathogens", + "lipidation", + "solution", + "interaction", + "inflammation", + "coli", "calcein", + "peptides", + "abilities", + "antimicrobial", + "associated", + "obtain", + "rising", + "designed", + "fluorescence", "reveal", - "become", - "two", - "uptake", - "polar", - "disulphide", - "bound", - "compactly", - "analogues", - "development", + "elucidate", + "dilution", + "assay", + "antimicrobials", + "phe12", + "conserved", "resistant", + "previously", + "performed", + "issue", + "structure", + "alternate", + "report", + "determined", + "serve", + "linkage", + "nmr", + "interactions", + "devastating", + "nature", + "concern", + "quenching", + "membrane", "diseases", - "major", - "global", - "organized", - "binding", - "formed", - "level" + "analogues", + "modified", + "uptake", + "high", + "negative", + "entrapped", + "years", + "studies", + "plant", + "potent", + "demand", + "plants", + "human", + "xanthomonas", + "stabilized", + "permeabilization", + "novel" ], "release_date":"2016-03-23", "publication":"\"Designing potent antimicrobial peptides by disulphide linked dimerization and N-terminal lipidation to increase antimicrobial activity and membrane perturbation: Structural insights into lipopolysaccharide binding\", J Colloid Interface Sci, 461, 335-345", @@ -31731,159 +31753,159 @@ "tags":[ "disulphide linked vg16krkp homodimer", "de novo protein, antimicrobial protein", - "de novo protein", "antimicrobial protein", + "de novo protein", "designed antimicrobial peptide" ], "keywords":[ - "neutralisation", - "studies", - "already", - "potent", - "permeabilization", - "issue", - "conserved", - "including", - "lipopolysaccharide", - "peptide", - "designed", - "plant", - "analogue", - "determined", - "obtain", - "interactions", - "enhanced", - "accounts", - "antibacterial", - "therefore", - "structure", + "hemolytic", + "molecular", + "triad", + "leakage", "insights", - "plants", - "health", - "fluorescence", - "pathogen", - "novel", - "therapeutic", - "xanthomonas", - "pv", - "interaction", - "develop", - "chain", - "inflammation", - "membrane", - "demand", - "scavenging", + "development", + "resolution", + "hydrophobic", + "structural", + "organized", + "possessed", + "separation", + "therefore", + "well", "endotoxin", - "face", - "septicemia", - "similar", - "pseudomonas", - "assay", - "entrapped", - "antibiotics", "presence", - "serve", - "lps", - "motif", - "nature", - "separation", - "vesicle", - "alternate", - "solution", - "future", - "antimicrobials", - "constraint", - "dilution", - "either", - "campestris", - "effects", - "anisotropy", - "lipidation", + "lipopolysaccharide", "vg16krkp", - "performed", - "triad", - "previously", - "investigate", - "neutralization", - "quenching", - "elucidate", - "parent", - "possessed", - "control", - "leakage", - "years", - "molecular", - "associated", "via", - "remarkable", - "permeabilisation", - "antimicrobial", - "report", - "coli", - "acyl", - "resolution", - "concern", - "template", + "pseudomonas", + "study", "activities", - "microbroth", - "dye", - "devastating", - "leu11", - "super", - "bond", - "context", - "hydrophobic", - "negative", - "nmr", - "recent", - "high", - "linkage", - "stabilized", - "increase", - "phe12", - "abilities", - "hemolytic", - "gram", - "aeruginosa", - "non", - "conventional", - "structural", + "compactly", + "pathogen", + "disulphide", + "binding", "dimerization", - "susceptible", + "motif", "bacterial", - "trp5", - "rise", - "rising", - "study", - "modified", + "super", + "acyl", + "antibacterial", + "susceptible", + "leu11", + "major", + "two", + "parent", + "recent", "offer", "attractive", + "global", + "effects", + "trp5", + "face", + "accounts", + "similar", + "rise", + "either", + "analogue", + "anisotropy", + "formed", + "neutralisation", + "dye", + "pv", + "level", + "polar", + "antibiotics", + "septicemia", + "control", "npn", - "human", - "pathogens", - "humans", - "peptides", + "become", + "permeabilisation", + "bound", + "develop", + "remarkable", + "constraint", + "neutralization", + "conventional", + "vesicle", + "aeruginosa", + "gram", + "bond", + "campestris", + "future", + "including", + "peptide", + "investigate", + "increase", + "enhanced", + "already", + "context", + "scavenging", "spectroscopy", - "well", + "chain", + "health", + "microbroth", + "lps", + "therapeutic", + "humans", + "template", + "non", + "pathogens", + "lipidation", + "solution", + "interaction", + "inflammation", + "coli", "calcein", + "peptides", + "abilities", + "antimicrobial", + "associated", + "obtain", + "rising", + "designed", + "fluorescence", "reveal", - "become", - "two", - "uptake", - "polar", - "disulphide", - "bound", - "compactly", - "analogues", - "development", + "elucidate", + "dilution", + "assay", + "antimicrobials", + "phe12", + "conserved", "resistant", + "previously", + "performed", + "issue", + "structure", + "alternate", + "report", + "determined", + "serve", + "linkage", + "nmr", + "interactions", + "devastating", + "nature", + "concern", + "quenching", + "membrane", "diseases", - "major", - "global", - "organized", - "binding", - "formed", - "level" + "analogues", + "modified", + "uptake", + "high", + "negative", + "entrapped", + "years", + "studies", + "plant", + "potent", + "demand", + "plants", + "human", + "xanthomonas", + "stabilized", + "permeabilization", + "novel" ], "release_date":"2016-03-23", "publication":"\"Designing potent antimicrobial peptides by disulphide linked dimerization and N-terminal lipidation to increase antimicrobial activity and membrane perturbation: Structural insights into lipopolysaccharide binding\", J Colloid Interface Sci, 461, 335-345", @@ -31984,56 +32006,56 @@ "de novo protein" ], "keywords":[ - "stability", - "analysis", - "evidence", - "supports", - "magnetic", - "via", - "aqueous", - "spectra", - "stable", + "designed", "whether", - "hypothesis", - "experimental", - "increasing", - "examined", - "among", "cooperativity", - "peptides", - "designed", + "analysis", + "adopt", + "design", "number", - "cd", "spectroscopy", - "may", - "enable", - "documentation", - "two", - "nuclear", - "parallel", - "becomes", "show", - "design", + "experimental", + "first", + "three", + "becomes", + "via", + "increases", + "structure", + "properties", + "among", + "characteristic", + "folding", + "cd", "model", - "comparisons", - "adopt", - "present", - "secondary", + "spectra", + "supports", "nmr", + "documentation", + "magnetic", + "stability", "solution", - "structure", + "evidence", + "enable", + "comparisons", + "may", + "parallel", + "examined", "resonance", - "three", - "circular", - "minimal", - "first", "dichroism", - "folding", - "conformations", "systems", - "increases", - "characteristic", - "properties" + "peptides", + "circular", + "conformations", + "two", + "nuclear", + "present", + "secondary", + "stable", + "aqueous", + "hypothesis", + "increasing", + "minimal" ], "release_date":"2015-10-28", "publication":"\"Impact of Strand Number on Parallel beta-Sheet Stability\", Angew.Chem.Int.Ed.Engl., 54, 14336-14339", @@ -32131,56 +32153,56 @@ "de novo protein" ], "keywords":[ - "stability", - "analysis", - "evidence", - "supports", - "magnetic", - "via", - "aqueous", - "spectra", - "stable", + "designed", "whether", - "hypothesis", - "experimental", - "increasing", - "examined", - "among", "cooperativity", - "peptides", - "designed", + "analysis", + "adopt", + "design", "number", - "cd", "spectroscopy", - "may", - "enable", - "documentation", - "two", - "nuclear", - "parallel", - "becomes", "show", - "design", + "experimental", + "first", + "three", + "becomes", + "via", + "increases", + "structure", + "properties", + "among", + "characteristic", + "folding", + "cd", "model", - "comparisons", - "adopt", - "present", - "secondary", + "spectra", + "supports", "nmr", + "documentation", + "magnetic", + "stability", "solution", - "structure", + "evidence", + "enable", + "comparisons", + "may", + "parallel", + "examined", "resonance", - "three", - "circular", - "minimal", - "first", "dichroism", - "folding", - "conformations", "systems", - "increases", - "characteristic", - "properties" + "peptides", + "circular", + "conformations", + "two", + "nuclear", + "present", + "secondary", + "stable", + "aqueous", + "hypothesis", + "increasing", + "minimal" ], "release_date":"2015-10-28", "publication":"\"Impact of Strand Number on Parallel beta-Sheet Stability\", Angew.Chem.Int.Ed.Engl., 54, 14336-14339", @@ -32312,11 +32334,11 @@ ], "subtitle":"Solution nmr structure of de novo designed protein, rossmann2x2 fold, northeast structural genomics consortium (nesg) target or446", "tags":[ - "northeast structural genomics consortium", - "structural genomics", "protein structure initiative", - "de novo protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", + "structural genomics", "psi-biology" ], "keywords":[ @@ -32469,11 +32491,11 @@ ], "subtitle":"Solution nmr structure of de novo designed protein lfr1 1 with ferredoxin fold, northeast structural genomics consortium (nesg) target or414", "tags":[ - "northeast structural genomics consortium", - "structural genomics", "protein structure initiative", - "de novo protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", + "structural genomics", "psi-biology" ], "keywords":[ @@ -32605,46 +32627,46 @@ "de novo protein" ], "keywords":[ - "control", + "correlated", + "knowledge", "analysis", - "conditions", - "receptors", - "investigated", + "behavior", + "limited", + "design", + "energy", "conformational", - "potent", + "investigated", + "receptors", + "number", + "3", + "agonists", + "roles", + "biological", + "selective", + "synthesis", "report", - "homeostasis", + "ligands", + "mc3", + "docking", + "control", + "known", + "4", + "conditions", "contrast", + "activity", + "broadly", "lacking", - "human", - "roles", - "number", - "melanocortin", - "4", - "receptor", - "mc3", - "pathophysiological", "physiological", - "synthesis", "two", - "activity", - "agonists", - "behavior", - "3", - "limited", "mc4r", - "design", - "selective", + "potent", + "related", "mc3r", - "knowledge", - "docking", - "biological", - "energy", - "broadly", - "ligands", - "known", - "correlated", - "related" + "pathophysiological", + "human", + "homeostasis", + "melanocortin", + "receptor" ], "release_date":"2015-12-16", "publication":"\"Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor\", J.Med.Chem., 58, 9773-9778", @@ -32762,46 +32784,46 @@ "de novo protein" ], "keywords":[ - "control", + "correlated", + "knowledge", "analysis", - "conditions", - "receptors", - "investigated", + "behavior", + "limited", + "design", + "energy", "conformational", - "potent", + "investigated", + "receptors", + "number", + "3", + "agonists", + "roles", + "biological", + "selective", + "synthesis", "report", - "homeostasis", + "ligands", + "mc3", + "docking", + "control", + "known", + "4", + "conditions", "contrast", + "activity", + "broadly", "lacking", - "human", - "roles", - "number", - "melanocortin", - "4", - "receptor", - "mc3", - "pathophysiological", "physiological", - "synthesis", "two", - "activity", - "agonists", - "behavior", - "3", - "limited", "mc4r", - "design", - "selective", + "potent", + "related", "mc3r", - "knowledge", - "docking", - "biological", - "energy", - "broadly", - "ligands", - "known", - "correlated", - "related" + "pathophysiological", + "human", + "homeostasis", + "melanocortin", + "receptor" ], "release_date":"2015-12-16", "publication":"\"Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor\", J.Med.Chem., 58, 9773-9778", @@ -32919,46 +32941,46 @@ "de novo protein" ], "keywords":[ - "control", + "correlated", + "knowledge", "analysis", - "conditions", - "receptors", - "investigated", + "behavior", + "limited", + "design", + "energy", "conformational", - "potent", + "investigated", + "receptors", + "number", + "3", + "agonists", + "roles", + "biological", + "selective", + "synthesis", "report", - "homeostasis", + "ligands", + "mc3", + "docking", + "control", + "known", + "4", + "conditions", "contrast", + "activity", + "broadly", "lacking", - "human", - "roles", - "number", - "melanocortin", - "4", - "receptor", - "mc3", - "pathophysiological", "physiological", - "synthesis", "two", - "activity", - "agonists", - "behavior", - "3", - "limited", "mc4r", - "design", - "selective", + "potent", + "related", "mc3r", - "knowledge", - "docking", - "biological", - "energy", - "broadly", - "ligands", - "known", - "correlated", - "related" + "pathophysiological", + "human", + "homeostasis", + "melanocortin", + "receptor" ], "release_date":"2015-12-16", "publication":"\"Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor\", J.Med.Chem., 58, 9773-9778", @@ -33109,70 +33131,70 @@ "de novo protein, antimicrobial peptide" ], "keywords":[ - "defense", - "generating", - "innovative", - "generation", - "demonstrate", - "dynamically", - "results", - "chemistry", - "proves", "membranes", - "membrane", - "unique", - "chemical", - "host", - "presented", - "de", - "novo", - "composition", - "study", - "template", - "medicinal", - "peptide", - "peptides", - "pathogens", - "method", + "templates", "designed", - "mode", - "growing", - "moments", - "specific", - "terms", - "activity", - "constitute", - "innate", + "form", "central", + "chemistry", + "terms", + "aspect", + "generation", "anticipated", - "potential", - "introduced", "design", - "action", - "mechanism", - "concept", - "helical", - "lipid", - "interactions", - "kinked", - "templates", - "pores", + "moments", "hydrophobic", - "antibacterial", + "dependent", + "de", + "action", "natural", + "biology", + "inspired", + "potential", + "representation", + "defense", + "concept", "outperform", - "essential", + "specific", "structure", - "cellular", - "representation", - "dependent", + "results", + "host", "appropriate", - "biology", - "computational", - "form", - "inspired", + "template", "communication", - "aspect" + "proves", + "interactions", + "medicinal", + "study", + "constitute", + "membrane", + "lipid", + "pathogens", + "mode", + "helical", + "dynamically", + "innovative", + "cellular", + "innate", + "essential", + "presented", + "growing", + "novo", + "activity", + "demonstrate", + "antibacterial", + "peptides", + "pores", + "generating", + "composition", + "chemical", + "unique", + "mechanism", + "introduced", + "method", + "computational", + "peptide", + "kinked" ], "release_date":"2017-01-18", "publication":"\"Rational Design of Membrane-Pore-Forming Peptides\", Small, 13", @@ -33287,70 +33309,70 @@ ], "subtitle":"Solution nmr structure of designed protein da05, northeast structural genomics consortium (nesg) target or626", "tags":[ - "northeast structural genomics consortium", - "de novo protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", "designed protein", "psi-biology" ], "keywords":[ - "diverse", - "builds", - "cases", - "angstrom", - "called", - "excellent", - "magnetic", - "proteins", - "connected", + "tertiary", + "designed", "models", - "solved", - "respectively", - "large", - "remain", - "process", - "de", - "novo", - "strategy", + "angstrom", + "design", + "structural", "resolution", - "scaffolds", - "crystallography", - "rapidly", - "method", - "designed", - "preexisting", - "functions", - "da05r1", + "diverse", + "provides", + "structures", + "de", + "respectively", + "natural", "agreement", + "inspired", + "called", + "rapidly", + "scaffolds", "protocol", "ca01", - "nuclear", + "new", + "strategy", + "connected", + "functions", + "numbers", + "crystallography", + "designable", + "protein", + "magnetic", "folded", - "provides", - "absent", - "features", - "design", + "cases", + "proteins", "helical", - "structures", - "protein", - "natural", - "existing", - "describe", - "tertiary", + "large", + "process", + "absent", + "builds", + "novo", + "remain", "resonance", + "preexisting", "pieces", + "solved", + "excellent", + "contain", + "sewing", "combines", - "computational", + "disconnected", + "existing", + "nuclear", "recombination", - "numbers", - "designable", - "sewing", - "inspired", - "structural", + "describe", + "features", + "da05r1", "create", - "contain", - "disconnected", - "new" + "method", + "computational" ], "release_date":"2016-01-20", "publication":"\"Design of structurally distinct proteins using strategies inspired by evolution\", Science, 352, 687-690", @@ -33393,11 +33415,11 @@ }, { "sim":59.0, - "partner":"4i9e" + "partner":"3ulq" }, { "sim":59.0, - "partner":"3ulq" + "partner":"4i9e" } ], "struct_thr_sim_designed":[ @@ -33482,71 +33504,71 @@ ], "subtitle":"Solution nmr structure of designed protein da05r1, northeast structural genomics consortium (nesg) target or690", "tags":[ + "nesg", + "de novo protein", "northeast structural genomics consortium", "structural genomics", - "de novo protein", "designed protein", - "nesg", "psi-biology" ], "keywords":[ - "diverse", - "builds", - "cases", - "angstrom", - "called", - "excellent", - "magnetic", - "proteins", - "connected", + "tertiary", + "designed", "models", - "solved", - "respectively", - "large", - "remain", - "process", - "de", - "novo", - "strategy", + "angstrom", + "design", + "structural", "resolution", - "scaffolds", - "crystallography", - "rapidly", - "method", - "designed", - "preexisting", - "functions", - "da05r1", + "diverse", + "provides", + "structures", + "de", + "respectively", + "natural", "agreement", + "inspired", + "called", + "rapidly", + "scaffolds", "protocol", "ca01", - "nuclear", + "new", + "strategy", + "connected", + "functions", + "numbers", + "crystallography", + "designable", + "protein", + "magnetic", "folded", - "provides", - "absent", - "features", - "design", + "cases", + "proteins", "helical", - "structures", - "protein", - "natural", - "existing", - "describe", - "tertiary", + "large", + "process", + "absent", + "builds", + "novo", + "remain", "resonance", + "preexisting", "pieces", + "solved", + "excellent", + "contain", + "sewing", "combines", - "computational", + "disconnected", + "existing", + "nuclear", "recombination", - "numbers", - "designable", - "sewing", - "inspired", - "structural", + "describe", + "features", + "da05r1", "create", - "contain", - "disconnected", - "new" + "method", + "computational" ], "release_date":"2015-11-25", "publication":"\"Design of structurally distinct proteins using strategies inspired by evolution\", Science, 352, 687-690", @@ -33589,11 +33611,11 @@ }, { "sim":55.0, - "partner":"4i9e" + "partner":"3ulq" }, { "sim":55.0, - "partner":"3ulq" + "partner":"4i9e" } ], "struct_thr_sim_designed":[ @@ -33849,77 +33871,77 @@ "engineered protein" ], "keywords":[ - "stability", - "covalent", - "thermal", - "combining", + "tertiary", + "12", + "models", "generation", - "excellent", - "tissue", + "naturally", + "design", + "constrained", "specified", - "models", - "restricted", - "larger", "specificity", - "use", - "chemical", - "presented", + "development", + "fit", + "methods", + "active", + "nearly", + "therapeutics", + "structures", "de", - "novo", - "stable", - "drugs", + "experimentally", + "combining", "encodable", + "conformationally", + "exceptionally", + "properties", "scaffolds", - "accurate", "pharmacologically", - "peptides", - "enable", - "would", - "subset", - "active", - "shapes", - "provide", - "precisely", - "methods", - "experimentally", - "heterochiral", - "occurring", - "constrained", - "ability", - "crosslinks", - "generally", + "targets", "determined", - "much", - "12", - "design", + "provide", + "residue", "new", + "precisely", + "subset", + "thermal", + "covalent", + "nmr", + "protein", "denaturation", + "inhibitors", "basis", - "therapeutics", - "naturally", - "protein", - "structures", - "residue", - "genetically", - "targets", - "exceptionally", - "pharmaceutical", + "crosslinks", "pockets", - "nmr", - "development", - "describe", - "tertiary", + "stability", + "tissue", + "accurate", + "would", + "generally", + "binding", + "pharmaceutical", + "genetically", + "enable", + "use", + "presented", + "ability", + "shapes", + "novo", + "much", + "heterochiral", + "peptides", + "excellent", + "drugs", + "larger", "identical", - "conformationally", - "arbitrary", - "fit", "penetration", + "chemical", + "arbitrary", + "stable", + "describe", + "restricted", "evolved", - "inhibitors", "computational", - "nearly", - "binding", - "properties" + "occurring" ], "release_date":"2016-09-21", "publication":"\"Accurate de novo design of hyperstable constrained peptides\", Nature, 538, 329-335", @@ -34116,77 +34138,77 @@ "engineered protein" ], "keywords":[ - "stability", - "covalent", - "thermal", - "combining", + "tertiary", + "12", + "models", "generation", - "excellent", - "tissue", + "naturally", + "design", + "constrained", "specified", - "models", - "restricted", - "larger", "specificity", - "use", - "chemical", - "presented", + "development", + "fit", + "methods", + "active", + "nearly", + "therapeutics", + "structures", "de", - "novo", - "stable", - "drugs", + "experimentally", + "combining", "encodable", + "conformationally", + "exceptionally", + "properties", "scaffolds", - "accurate", "pharmacologically", - "peptides", - "enable", - "would", - "subset", - "active", - "shapes", - "provide", - "precisely", - "methods", - "experimentally", - "heterochiral", - "occurring", - "constrained", - "ability", - "crosslinks", - "generally", + "targets", "determined", - "much", - "12", - "design", + "provide", + "residue", "new", + "precisely", + "subset", + "thermal", + "covalent", + "nmr", + "protein", "denaturation", + "inhibitors", "basis", - "therapeutics", - "naturally", - "protein", - "structures", - "residue", - "genetically", - "targets", - "exceptionally", - "pharmaceutical", + "crosslinks", "pockets", - "nmr", - "development", - "describe", - "tertiary", + "stability", + "tissue", + "accurate", + "would", + "generally", + "binding", + "pharmaceutical", + "genetically", + "enable", + "use", + "presented", + "ability", + "shapes", + "novo", + "much", + "heterochiral", + "peptides", + "excellent", + "drugs", + "larger", "identical", - "conformationally", - "arbitrary", - "fit", "penetration", + "chemical", + "arbitrary", + "stable", + "describe", + "restricted", "evolved", - "inhibitors", "computational", - "nearly", - "binding", - "properties" + "occurring" ], "release_date":"2016-09-21", "publication":"\"Accurate de novo design of hyperstable constrained peptides\", Nature, 538, 329-335", @@ -34289,90 +34311,90 @@ "subtitle":"Rh4b: designed right-handed coiled coil tetramer with all biological amino acids", "tags":[ "de novo protein", - "right-handed", - "tetramer" + "tetramer", + "right-handed" ], "keywords":[ - "equivalent", - "tetramer", - "results", - "utilized", - "map", - "suggest", - "metal", - "acid", - "designed", - "unbiased", - "parallel", - "crystal", - "determined", + "repeats", + "clarity", + "especially", + "nonbiological", + "structural", + "resolution", "show", - "structure", "repeat", - "pack", - "oligomer", - "however", - "molecule", - "coiled", - "angstrom", - "called", - "chain", - "family", - "spaces", - "resulting", - "particularly", - "structures", - "alternate", - "view", - "coils", - "populates", + "experimental", + "single", + "core", + "differences", "three", - "revealed", - "coil", - "phases", + "deviation", + "acid", "provided", - "per", - "amino", - "resolution", + "polypeptide", + "results", "accurate", - "acids", - "nonbiological", - "closely", + "electron", + "binding", "clear", - "design", - "polypeptide", - "core", - "using", - "sequence", - "repeats", - "biological", - "coordinate", - "structural", + "unanticipated", + "phases", "tetrameric", - "ion", - "density", + "site", + "rotamers", + "variety", + "crystal", + "stable", + "using", + "previous", + "metal", + "however", + "populates", "overall", - "efficiently", + "biological", + "particularly", + "family", + "matched", "entirely", - "stable", - "single", + "suggest", + "density", + "rh4b", "unprecedented", + "coils", "yb", - "clarity", - "matched", - "experimental", - "electron", - "deviation", - "rh4b", - "especially", - "unanticipated", - "rotamers", - "cores", - "binding", - "previous", - "variety", - "differences", - "site" + "molecule", + "tetramer", + "angstrom", + "design", + "chain", + "equivalent", + "called", + "utilized", + "amino", + "oligomer", + "map", + "parallel", + "sequence", + "view", + "per", + "designed", + "pack", + "revealed", + "structures", + "efficiently", + "structure", + "alternate", + "unbiased", + "determined", + "resulting", + "closely", + "coordinate", + "ion", + "spaces", + "coiled", + "coil", + "acids", + "cores" ], "release_date":"2007-10-23", "publication":"\"Structure of a designed, right-handed coiled-coil tetramer containing all biological amino acids\", Protein Sci., 16, 2224-2232", @@ -34483,115 +34505,115 @@ ], "subtitle":"Solution structure of a non-biological atp-binding protein", "tags":[ - "de novo protein", - "alpha\/beta fold; treble clef zinc binding motif" + "alpha\/beta fold; treble clef zinc binding motif", + "de novo protein" ], "keywords":[ - "analysis", + "affinity", "largely", - "significance", - "aggregation", - "biochemical", - "selection", + "optimized", + "functionality", + "hydrophobic", + "structural", + "well", + "differs", + "newly", "acid", - "stably", - "enhance", - "mutations", - "mutation", - "sequences", - "revert", - "enhanced", - "structure", - "affinity", - "enhancement", - "solved", - "face", - "rigidity", - "random", - "interpret", - "point", - "less", - "decreasing", - "version", - "used", - "ancestral", - "back", - "fourth", - "earlier", - "nuclear", - "evolutionary", - "vitro", - "folded", - "derived", - "hydrophilicity", - "solution", + "solubility", + "residue", + "folding", "noe", - "revealed", - "measurements", - "previously", - "investigate", - "series", - "stability", + "protein", + "increased", + "biochemical", "accumulation", - "data", - "functional", - "amino", - "strand", - "newly", - "thereby", - "resulted", + "vitro", + "binding", + "confirmed", "overhauser", - "increased", + "rigidity", + "nuclear", + "stable", + "face", + "revert", + "stably", + "decreasing", + "enhance", + "due", + "examine", + "identified", + "aggregation", + "charge", + "library", "optimization", + "derived", + "folded", + "stability", + "t1", + "positive", + "sites", + "several", + "ancestral", + "described", + "earlier", "may", - "t2", - "heteronuclear", - "examine", - "transformed", + "density", + "emergence", "stabilize", + "combination", + "investigate", + "measurements", "12", - "observed", - "biochemistry", - "crystallographic", - "functionality", - "several", - "present", - "hydrophobic", - "differs", - "nmr", "surface", - "high", + "mutagenesis", + "enhanced", + "selection", + "spectroscopy", + "used", + "heteronuclear", + "functional", + "atp", + "experiments", + "point", + "amino", + "biochemistry", + "solution", + "resulted", + "understood", + "series", "sequence", - "structural", - "sites", - "library", - "solubility", - "density", + "solved", + "present", + "crystallographic", + "mutation", + "fourth", + "evolutionary", + "evolutionarily", + "analysis", + "revealed", + "sequences", + "significance", "one", + "mutations", + "observed", "patch", - "optimized", - "described", - "stable", - "experiments", + "previously", + "enhancement", + "hydrophilicity", + "structure", + "thereby", + "nmr", + "transformed", "means", - "spectroscopy", - "well", - "emergence", - "charge", - "confirmed", - "understood", - "identified", - "due", - "atp", - "t1", - "positive", - "protein", - "residue", - "combination", - "folding", - "binding", - "evolutionarily", - "mutagenesis" + "t2", + "random", + "version", + "interpret", + "strand", + "high", + "data", + "less", + "back" ], "release_date":"2007-08-07", "publication":"\"Structure and Evolutionary Analysis of a Non-biological ATP-binding Protein\", J.Mol.Biol., 371, 501-513", @@ -34705,66 +34727,66 @@ "computational protein design" ], "keywords":[ - "thermal", - "differ", - "procedures", - "original", - "one", - "amino", - "melanogaster", - "drosophila", - "identity", - "proteins", - "entire", - "share", - "stable", - "template", - "acid", - "optimization", - "midpoints", "designed", - "spectroscopy", - "resulting", + "22", + "identity", + "redesign", + "design", + "sequences", "51", - "heteronuclear", - "closely", + "naturally", + "one", + "homeodomain", + "compared", "mutations", - "found", - "multidimensional", - "two", - "11", + "spectroscopy", + "algorithms", + "heteronuclear", + "computationally", "experimentally", - "22", - "occurring", + "drosophila", + "structure", + "multidimensional", + "acid", "determined", - "24", - "scaffold", - "match", - "design", - "sequences", - "denaturation", - "protein", + "resulting", "residue", - "considerably", - "naturally", - "using", + "closely", "degrees", - "99", + "various", + "thermal", "nmr", - "algorithms", + "template", + "protein", + "optimization", + "denaturation", + "amino", + "procedures", + "engrailed", + "share", + "melanogaster", + "proteins", "solution", - "structure", + "applied", "sequence", - "various", - "redesign", + "scaffold", + "greater", + "considerably", + "match", + "found", + "original", + "two", + "entire", + "using", + "stable", "evaluated", - "computationally", + "24", "computational", - "applied", - "engrailed", - "homeodomain", - "compared", - "greater" + "midpoints", + "99", + "11", + "occurring", + "differ" ], "release_date":"2007-08-14", "publication":"\"Full-sequence Computational Design and Solution Structure of a Thermostable Protein Variant\", J.Mol.Biol., 372, 1-6", @@ -34870,111 +34892,111 @@ ], "subtitle":"Crystal structure of a designed full consensus ankyrin", "tags":[ - "ankyrin repeat", "de novo protein", + "ankyrin repeat", "repeat protein", "helix-turn-helix-beta-turn" ], "keywords":[ - "least", - "thermal", - "containing", - "evidence", - "providing", - "stabilizing", - "thermostability", - "use", - "ions", - "place", - "designed", - "stabilities", - "ankyrins", - "crystal", - "determined", + "repeats", + "arrange", + "regularity", + "structural", + "sulfate", + "resolution", + "repeat", "show", - "based", - "complement", - "denaturation", - "interactions", - "suggested", - "members", "therefore", - "structure", - "c", - "repeat", - "networks", - "principles", - "even", - "interaction", - "hydrochloride", + "boiling", + "randomized", + "three", + "ni", + "make", "network", - "proteins", - "reach", + "protein", + "members", + "positions", + "salt", + "binding", + "thermodynamic", + "networks", + "charged", + "related", + "crystal", "similar", - "family", + "occurring", + "stabilities", + "reach", "characterized", - "feature", + "fixed", + "stabilizing", "almost", - "electrostatic", - "suggests", - "3", - "occurring", - "internal", - "naturally", - "positions", - "charged", - "thermophilic", - "three", - "ni", - "organisms", - "compared", - "consensus", + "selected", + "effect", + "exceptionally", + "bridges", + "residues", + "family", + "charge", + "place", + "library", "primarily", - "previously", + "thermal", + "hidden", + "denaturation", "stability", - "salt", - "sulfate", - "randomized", - "regularity", - "directly", - "resolution", - "fixed", - "bridges", - "thermodynamic", - "darpins", - "arrange", - "statistics", - "comparison", - "design", - "exceptionally", - "effect", + "proteins", + "evidence", + "ions", + "use", + "described", + "ankyrin", + "consensus", + "organisms", + "increase", + "c", "surface", - "high", + "design", + "compared", + "principles", + "electrostatic", + "even", + "suggests", + "feature", + "guanidine", + "experiments", + "complement", + "thermophilic", + "least", + "interaction", "sequence", - "repeats", + "suggested", + "identical", + "darpins", + "directly", + "designed", + "naturally", "indicate", - "increase", - "structural", - "selected", - "library", - "make", - "described", - "experiments", - "charge", - "ankyrin", - "residues", + "providing", + "resistant", + "statistics", + "3", + "previously", + "based", "darpin", - "hidden", - "protein", + "structure", + "thermostability", + "determined", + "interactions", + "ankyrins", + "hydrochloride", + "internal", "regular", - "identical", + "high", + "libraries", "contribution", - "resistant", - "boiling", - "guanidine", - "binding", - "related", - "libraries" + "containing", + "comparison" ], "release_date":"2007-11-13", "publication":"\"Stabilizing ionic interactions in a full-consensus ankyrin repeat protein\", J.Mol.Biol., 376, 232-240", @@ -35237,107 +35259,107 @@ ], "subtitle":"Nmr structure of designed protein, af.2a1, (ensembles)", "tags":[ + "de novo protein", "chignolin", - "artificial protein", - "de novo protein" + "artificial protein" ], "keywords":[ - "analysis", - "evolution", - "issue", - "selection", - "peptide", - "repetitive", - "mutation", - "support", - "determined", - "basis", - "conformation", - "chignolin", - "designing", - "structure", - "display", - "insights", - "distinguish", "affinity", - "novel", - "starting", - "molecule", - "proteins", - "presents", - "serves", - "immunoglobulin", - "organization", - "successfully", - "small", - "used", - "short", + "molecular", "recognition", - "evolutionary", - "ability", - "better", + "hydrophobic", + "structural", + "development", + "insights", + "core", + "differences", + "elongation", + "longstanding", + "polypeptide", + "short", + "model", + "protein", "autonomously", - "nanomolar", - "ever", - "biology", - "evolving", - "measurements", + "successfully", + "primordial", + "globular", + "study", + "propose", + "produced", + "exquisite", + "subsequent", + "forms", + "applications", + "region", + "using", + "methodology", + "conformation", "shows", - "fc", - "facilitate", + "conformational", + "organization", + "distinguish", + "starting", "discovered", - "reported", - "molecular", - "demonstrated", - "functional", - "phage", - "subsequent", + "vicinity", + "sized", + "termed", + "useful", + "basis", + "proteins", + "segment", + "small", + "evolution", "higher", - "globular", - "industrial", + "nanomolar", "hypothesis", - "artificial", + "facilitate", + "peptide", + "emerged", "smallest", - "elongation", - "useful", - "region", - "exquisite", + "molecule", + "measurements", + "chignolin", + "designing", + "selection", + "serves", "provides", - "biochemistry", - "produced", - "polypeptide", - "core", - "model", - "using", - "applications", - "hydrophobic", - "propose", - "pharmaceutical", - "nmr", - "longstanding", - "sequence", - "served", - "segment", - "sized", - "structural", - "fundamental", - "conformational", + "used", + "biology", + "functional", + "display", + "ever", "revealing", "also", - "study", - "termed", - "vicinity", + "industrial", + "biochemistry", + "served", + "ability", + "sequence", + "reported", + "demonstrated", + "fc", "cycles", - "protein", + "mutation", + "evolutionary", + "fundamental", + "analysis", + "presents", "synthesized", - "primordial", - "foldable", - "development", - "differences", - "emerged", + "issue", + "structure", + "repetitive", + "determined", + "nmr", "understanding", - "methodology", - "forms" + "pharmaceutical", + "artificial", + "phage", + "evolving", + "support", + "immunoglobulin", + "foldable", + "better", + "novel" ], "release_date":"2014-01-01", "publication":"\"Tracing primordial protein evolution through structurally guided stepwise segment elongation\", J.Biol.Chem., 289, 3394-3404", @@ -35473,81 +35495,81 @@ "subtitle":"Designed armadillo repeat protein self-assembled complex (yiim2-maii)", "tags":[ "solution complex", + "self-assembly", "solenoid repeat", "de novo protein", - "armadillo repeat motif", - "self-assembly" + "armadillo repeat motif" ], "keywords":[ - "built", - "demonstrate", - "early", - "consisting", - "evolution", - "importance", + "reveal", + "designed", + "whether", + "repeats", + "form", + "complex", + "simulations", "molecular", - "part", - "timescale", - "proteins", - "recapitulates", - "entire", - "investigated", - "similar", - "globule", "essentially", - "armrp", - "stable", - "contrast", - "modules", - "continuous", - "whether", - "propose", - "examined", - "fold", - "1", - "designed", + "hydrophobic", + "structural", + "investigated", + "\u03bcs", + "repeat", + "molten", + "show", + "structurally", + "built", "fragments", + "ym2", + "recapitulates", + "armrp", "denoted", - "interface", - "reveal", + "possible", + "intermediates", + "armadillo", + "ym3a", + "three", + "consisting", + "structure", + "fold", "fragment", - "ym2", - "two", - "motif", - "simulations", + "recognize", + "protein", + "propose", + "contacts", "existence", - "crystal", + "proteins", + "modules", + "part", + "dissociation", + "internal", + "continuous", + "motif", + "across", + "consensus", "constitutes", - "show", - "dynamics", - "nanomolar", - "protein", - "recognize", + "contrast", + "1", + "demonstrate", "adopts", + "globule", + "examined", "split", - "complex", + "interface", + "early", + "constant", "identical", - "hydrophobic", - "across", + "two", + "evolution", + "entire", + "crystal", + "stable", + "timescale", + "nanomolar", "corresponding", - "structure", - "three", - "constant", - "repeat", - "armadillo", - "repeats", - "molten", - "structurally", - "intermediates", - "form", - "possible", - "internal", - "structural", - "ym3a", - "consensus", - "contacts", - "\u03bcs", - "dissociation" + "similar", + "importance", + "dynamics" ], "release_date":"2014-07-23", "publication":"\"Spontaneous self-assembly of engineered armadillo repeat protein fragments into a folded structure\", Structure, 22, 985-995", @@ -35579,36 +35601,48 @@ "next_design":"2ru5", "seq_thr_sim_designed":[ { - "sim":218.0, - "partner":"4dba" + "sim":177.0, + "partner":"6s9m" }, { - "sim":218.0, - "partner":"4db8" + "sim":177.0, + "partner":"6s9n" }, { - "sim":198.0, - "partner":"4db9" + "sim":184.0, + "partner":"6s9p" + }, + { + "sim":195.0, + "partner":"6s9o" + }, + { + "sim":158.0, + "partner":"2ru5" + }, + { + "sim":218.0, + "partner":"4dba" }, { "sim":198.0, "partner":"4db6" }, { - "sim":198.0, - "partner":"5mfl" + "sim":218.0, + "partner":"4db8" }, { "sim":197.0, - "partner":"5mfo" + "partner":"5aei" }, { "sim":197.0, - "partner":"5mfh" + "partner":"5mfe" }, { - "sim":197.0, - "partner":"5mfn" + "sim":177.0, + "partner":"6s9l" }, { "sim":197.0, @@ -35620,83 +35654,75 @@ }, { "sim":197.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":197.0, - "partner":"5mfe" + "partner":"5mfn" }, { - "sim":195.0, - "partner":"6s9o" + "sim":198.0, + "partner":"5mfl" }, { - "sim":192.0, - "partner":"4v3o" + "sim":179.0, + "partner":"7r0r" }, { "sim":191.0, "partner":"5mfd" }, { - "sim":188.0, - "partner":"4v3q" - }, - { - "sim":187.0, - "partner":"4v3r" + "sim":171.0, + "partner":"6sa6" }, { - "sim":184.0, - "partner":"6s9p" + "sim":177.0, + "partner":"7qnp" }, { - "sim":179.0, - "partner":"7r0r" + "sim":177.0, + "partner":"6sa7" }, { - "sim":177.0, - "partner":"7qnp" + "sim":187.0, + "partner":"4v3r" }, { - "sim":177.0, - "partner":"6s9l" + "sim":192.0, + "partner":"4v3o" }, { - "sim":177.0, - "partner":"6s9n" + "sim":188.0, + "partner":"4v3q" }, { - "sim":177.0, - "partner":"6s9m" + "sim":197.0, + "partner":"5mfo" }, { - "sim":177.0, - "partner":"6sa7" + "sim":198.0, + "partner":"4db9" }, { "sim":177.0, "partner":"6sa8" }, { - "sim":171.0, - "partner":"6sa6" + "sim":142.0, + "partner":"4d49" }, { - "sim":145.0, - "partner":"5mfi" + "sim":142.0, + "partner":"5mfk" }, { "sim":145.0, "partner":"5mfj" }, { - "sim":142.0, - "partner":"4d49" - }, - { - "sim":142.0, - "partner":"5mfk" + "sim":145.0, + "partner":"5mfi" }, { "sim":122.0, @@ -35706,10 +35732,6 @@ "sim":121.0, "partner":"5mfb" }, - { - "sim":158.0, - "partner":"2ru5" - }, { "sim":97.0, "partner":"4rzp" @@ -35740,10 +35762,6 @@ "sim":117.0, "partner":"2c1t" }, - { - "sim":116.0, - "partner":"1wa5" - }, { "sim":115.0, "partner":"1bk5" @@ -35753,40 +35771,8 @@ "partner":"1bk6" }, { - "sim":93.0, - "partner":"4b8p" - }, - { - "sim":93.0, - "partner":"2yns" - }, - { - "sim":93.0, - "partner":"4b8o" - }, - { - "sim":92.0, - "partner":"4bpl" - }, - { - "sim":92.0, - "partner":"4bqk" - }, - { - "sim":92.0, - "partner":"4b8j" - }, - { - "sim":89.0, - "partner":"3fex" - }, - { - "sim":89.0, - "partner":"3fey" - }, - { - "sim":89.0, - "partner":"4e4v" + "sim":116.0, + "partner":"1wa5" }, { "sim":87.0, @@ -35816,21 +35802,17 @@ "sim":87.0, "partner":"1ial" }, - { - "sim":87.0, - "partner":"3q5u" - }, { "sim":87.0, "partner":"4oih" }, { "sim":87.0, - "partner":"1ejl" + "partner":"3knd" }, { "sim":87.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":87.0, @@ -35838,11 +35820,11 @@ }, { "sim":87.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":87.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":87.0, @@ -35850,7 +35832,7 @@ }, { "sim":87.0, - "partner":"3zir" + "partner":"3q5u" }, { "sim":87.0, @@ -35872,6 +35854,10 @@ "sim":87.0, "partner":"3ziq" }, + { + "sim":87.0, + "partner":"3zir" + }, { "sim":87.0, "partner":"1q1s" @@ -35881,28 +35867,32 @@ "partner":"1q1t" }, { - "sim":87.0, - "partner":"4ba3" + "sim":89.0, + "partner":"3fex" }, { - "sim":87.0, - "partner":"4htv" + "sim":89.0, + "partner":"3fey" + }, + { + "sim":89.0, + "partner":"4e4v" }, { "sim":87.0, - "partner":"4mz5" + "partner":"4ba3" }, { "sim":87.0, - "partner":"4mz6" + "partner":"4mz5" }, { "sim":87.0, - "partner":"3rzx" + "partner":"4mz6" }, { "sim":87.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":87.0, @@ -35937,8 +35927,12 @@ "partner":"3uvu" }, { - "sim":86.0, - "partner":"3tpo" + "sim":87.0, + "partner":"3rzx" + }, + { + "sim":87.0, + "partner":"3oqs" }, { "sim":85.0, @@ -35951,6 +35945,34 @@ { "sim":85.0, "partner":"2jdq" + }, + { + "sim":86.0, + "partner":"3tpo" + }, + { + "sim":92.0, + "partner":"4bpl" + }, + { + "sim":92.0, + "partner":"4bqk" + }, + { + "sim":93.0, + "partner":"2yns" + }, + { + "sim":93.0, + "partner":"4b8o" + }, + { + "sim":93.0, + "partner":"4b8p" + }, + { + "sim":92.0, + "partner":"4b8j" } ], "struct_thr_sim_designed":[ @@ -36047,80 +36069,80 @@ ], "subtitle":"Designed armadillo repeat protein fragment (maii)", "tags":[ - "armadillo repeat motif", "de novo protein", + "armadillo repeat motif", "solenoid repeat" ], "keywords":[ - "built", - "demonstrate", - "early", - "consisting", - "evolution", - "importance", + "reveal", + "designed", + "whether", + "repeats", + "form", + "complex", + "simulations", "molecular", - "part", - "timescale", - "proteins", - "recapitulates", - "entire", - "investigated", - "similar", - "globule", "essentially", - "armrp", - "stable", - "contrast", - "modules", - "continuous", - "whether", - "propose", - "examined", - "fold", - "1", - "designed", + "hydrophobic", + "structural", + "investigated", + "\u03bcs", + "repeat", + "molten", + "show", + "structurally", + "built", "fragments", + "ym2", + "recapitulates", + "armrp", "denoted", - "interface", - "reveal", + "possible", + "intermediates", + "armadillo", + "ym3a", + "three", + "consisting", + "structure", + "fold", "fragment", - "ym2", - "two", - "motif", - "simulations", + "recognize", + "protein", + "propose", + "contacts", "existence", - "crystal", + "proteins", + "modules", + "part", + "dissociation", + "internal", + "continuous", + "motif", + "across", + "consensus", "constitutes", - "show", - "dynamics", - "nanomolar", - "protein", - "recognize", + "contrast", + "1", + "demonstrate", "adopts", + "globule", + "examined", "split", - "complex", + "interface", + "early", + "constant", "identical", - "hydrophobic", - "across", + "two", + "evolution", + "entire", + "crystal", + "stable", + "timescale", + "nanomolar", "corresponding", - "structure", - "three", - "constant", - "repeat", - "armadillo", - "repeats", - "molten", - "structurally", - "intermediates", - "form", - "possible", - "internal", - "structural", - "ym3a", - "consensus", - "contacts", - "\u03bcs", - "dissociation" + "similar", + "importance", + "dynamics" ], "release_date":"2014-07-23", "publication":"\"Spontaneous self-assembly of engineered armadillo repeat protein fragments into a folded structure\", Structure, 22, 985-995", @@ -36153,11 +36175,11 @@ "seq_thr_sim_designed":[ { "sim":160.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":160.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":160.0, @@ -36185,11 +36207,11 @@ }, { "sim":158.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":158.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":158.0, @@ -36205,11 +36227,11 @@ }, { "sim":158.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":158.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":158.0, @@ -36269,11 +36291,11 @@ }, { "sim":93.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":93.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":87.0, @@ -36353,21 +36375,17 @@ "sim":58.0, "partner":"1ial" }, - { - "sim":58.0, - "partner":"3q5u" - }, { "sim":58.0, "partner":"4oih" }, { "sim":58.0, - "partner":"1ejl" + "partner":"3knd" }, { "sim":58.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":58.0, @@ -36375,11 +36393,11 @@ }, { "sim":58.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":58.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":58.0, @@ -36387,7 +36405,7 @@ }, { "sim":58.0, - "partner":"3zir" + "partner":"3q5u" }, { "sim":58.0, @@ -36409,6 +36427,10 @@ "sim":58.0, "partner":"3ziq" }, + { + "sim":58.0, + "partner":"3zir" + }, { "sim":58.0, "partner":"1q1s" @@ -36433,10 +36455,6 @@ "sim":58.0, "partner":"4ba3" }, - { - "sim":58.0, - "partner":"4htv" - }, { "sim":58.0, "partner":"4mz5" @@ -36447,11 +36465,7 @@ }, { "sim":58.0, - "partner":"3rzx" - }, - { - "sim":58.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":58.0, @@ -36485,6 +36499,14 @@ "sim":58.0, "partner":"3uvu" }, + { + "sim":58.0, + "partner":"3rzx" + }, + { + "sim":58.0, + "partner":"3oqs" + }, { "sim":57.0, "partner":"4b18" @@ -36511,15 +36533,15 @@ }, { "sim":53.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":53.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":53.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":53.0, @@ -36534,7 +36556,7 @@ ], "seq_max_sim_designed":{ "sim":160.0, - "partner":"6s9n" + "partner":"6s9m" }, "seq_max_sim_natural":{ "sim":70.0, @@ -36616,64 +36638,64 @@ ], "subtitle":"Nmr structure of a mutant of chignolin, cln025", "tags":[ - "chignolin", "de novo protein", - "beta-hairpin", - "mini-protein" + "mini-protein", + "chignolin", + "beta-hairpin" ], "keywords":[ - "stability", - "thermal", - "without", - "question", - "consisting", - "characteristics", - "despite", - "answer", - "amino", - "network", - "proteins", - "pathway", - "us", - "established", - "whether", - "smallest", - "among", - "acids", + "molecule", "designed", - "define", + "whether", + "surface", "kind", - "10", - "small", - "simple", + "revealed", + "energy", "inquiring", - "existence", - "nature", - "crystal", + "impels", "ideal", - "deepens", - "protein", - "actually", "natural", - "surface", - "describe", - "essential", + "simple", + "us", + "question", + "define", + "consisting", + "free", + "properties", + "without", "structure", - "solution", - "revealed", - "definition", - "impels", - "size", - "energy", - "understanding", - "scientists", + "among", "folding", - "free", - "consistent", + "scientists", "occurs", - "molecule", + "thermal", + "protein", + "network", + "existence", + "nature", + "amino", + "stability", + "understanding", + "proteins", + "solution", + "size", + "essential", "consensus", - "properties" + "established", + "pathway", + "answer", + "definition", + "small", + "deepens", + "acids", + "despite", + "crystal", + "actually", + "describe", + "10", + "characteristics", + "smallest", + "consistent" ], "release_date":"2015-08-12", "publication":"\"Crystal structure of a ten-amino acid protein\", J.Am.Chem.Soc., 130, 15327-15331", @@ -36768,111 +36790,111 @@ ], "subtitle":"Crystal structure of ctpr3y3", "tags":[ - "tetratricopeptide", - "tpr domain", "de novo protein", - "mutant" + "tetratricopeptide", + "mutant", + "tpr domain" ], "keywords":[ - "work", - "domain", - "interpretation", + "trimer", + "crafting", + "structural", "ybgf", - "evidence", - "oligomers", - "monomeric", - "located", - "homologs", + "additional", + "repeat", + "acts", + "key", "complexes", - "trimer", - "conserved", - "tyrosines", + "regulation", "regulated", - "organizing", + "protein", + "study", + "across", + "motif", + "ctpr3y3", + "domains", + "stacking", + "motifs", "induced", "crystal", - "acts", - "order", - "basis", - "regions", - "interactions", - "module", - "multitude", - "regulating", - "structure", - "repeat", - "hydrophilic", - "explaining", - "leads", - "oligomer", - "however", - "ctpr3", - "restricts", - "interaction", + "involved", "centre", - "suggesting", + "asymmetric", + "engineered", + "interpretation", + "shows", + "however", + "displacement", + "biological", + "identified", + "residues", + "helix", + "level", + "hydrophilic", + "lays", + "occur", + "basis", + "stability", "proteins", - "borne", - "involved", - "processes", - "trimerization", - "crafting", - "beyond", - "motif", - "subtracting", - "trimeric", - "onto", - "capping", - "solution", - "linked", - "motifs", + "tetratricopeptide", "foundations", - "additional", - "shows", + "evidence", "consensus", - "previously", - "stability", - "tol", - "data", - "displacement", - "regulation", + "suggesting", "higher", - "oligomerization", - "accumulating", - "asymmetric", - "shown", - "bacteria", + "linked", "introduced", - "tpr", - "occur", - "present", + "regions", + "bacteria", "required", - "across", - "biological", - "key", - "formation", - "structural", - "lays", - "ctpr3y3", - "despite", + "characterize", "lack", - "study", - "experiments", + "onto", + "work", + "domain", + "processes", "fold", - "stacking", - "engineered", - "residues", - "characterize", - "tetratricopeptide", - "identified", + "leads", + "experiments", + "beyond", + "oligomerization", + "shown", + "multitude", + "solution", + "formation", + "oligomer", + "interaction", "system", - "domains", - "protein", - "helix", + "organizing", + "accumulating", + "borne", + "present", + "regulating", + "tol", + "trimerization", + "trimeric", + "order", + "ctpr3", + "conserved", + "loop", + "tpr", + "oligomers", + "previously", + "tyrosines", + "module", + "monomeric", + "structure", + "homologs", "block", + "interactions", + "capping", "understanding", - "loop", - "level" + "located", + "restricts", + "explaining", + "subtracting", + "despite", + "data" ], "release_date":"2010-04-07", "publication":"\"Self-association of TPR domains: Lessons learned from a designed, consensus-based TPR oligomer\", Proteins, 78, 2131-2143", @@ -36905,11 +36927,11 @@ "seq_thr_sim_designed":[ { "sim":230.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":230.0, - "partner":"8cqq" + "partner":"8cqp" }, { "sim":230.0, @@ -36917,27 +36939,27 @@ }, { "sim":230.0, - "partner":"8chy" + "partner":"8cmq" }, { "sim":230.0, - "partner":"8cmq" + "partner":"8bu0" }, { "sim":230.0, - "partner":"8ckr" + "partner":"8cp8" }, { "sim":230.0, - "partner":"8cig" + "partner":"8cqq" }, { "sim":230.0, - "partner":"8cqp" + "partner":"8chy" }, { "sim":230.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":222.0, @@ -36973,11 +36995,11 @@ }, { "sim":140.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":140.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":130.0, @@ -36989,15 +37011,15 @@ }, { "sim":85.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":85.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":85.0, - "partner":"8cus" + "partner":"8cwz" }, { "sim":83.0, @@ -37161,7 +37183,7 @@ ], "seq_max_sim_designed":{ "sim":230.0, - "partner":"8bu0" + "partner":"8ckr" }, "seq_max_sim_natural":{ "sim":96.0, @@ -37223,155 +37245,155 @@ ], "subtitle":"Crystal structure of coil ser l19c", "tags":[ - "three stranded coiled coil", "de novo protein", "apo", - "de novo design" + "de novo design", + "three stranded coiled coil" ], "keywords":[ - "reports", - "constructs", - "heptad", - "herein", - "thus", - "use", - "metal", - "ions", - "scaffolds", - "crystallography", - "pb", - "peptide", - "time", - "designed", - "cd", - "hg", - "questions", - "provide", - "parallel", - "crystal", - "determined", - "exist", - "ii", - "nonmetalated", - "show", - "decades", - "basis", - "realized", - "position", - "bind", - "structure", - "establish", + "metallopeptides", + "leucines", + "defined", + "hydrophobic", + "structural", "repeat", - "held", - "zn", - "conformer", - "metallobiochemistry", - "however", - "conformations", - "spectroscopic", - "interfaces", - "general", - "coiled", - "resultant", + "show", + "cs", + "clarify", + "single", + "side", + "differences", + "heavy", + "cd", + "pb", + "insight", + "protein", "partially", - "differential", - "proteins", - "de", - "metalloregulatory", - "yielding", - "organization", - "influence", - "metallochaperones", - "used", - "yet", - "3", - "preorganized", - "dreams", - "forming", - "structures", - "ultimately", - "alternate", "pockets", - "coils", - "versus", - "corresponding", + "metallochaperones", + "binding", + "changes", "essential", - "assembly", - "suitable", - "either", - "cysteines", - "coil", - "cs", - "first", - "rules", + "site", + "novo", + "yielding", + "metallobiochemistry", + "general", + "csl19c", "systems", - "glu", - "quality", - "data", - "replaced", - "respectively", - "defined", - "generate", - "changes", - "may", - "19", - "9", - "iii", - "g", - "behavior", + "forms", "apo", - "metalated", - "observed", - "metals", - "characterization", "promise", + "two", + "variety", + "crystal", + "establish", + "hg", + "chains", + "dreams", + "questions", + "g", + "rules", + "zn", + "corresponding", "using", - "present", - "hydrophobic", + "resultant", + "either", "elaborate", - "ser", - "heavy", - "coordinate", - "packing", - "structural", - "metallopeptides", - "inherent", + "however", + "metal", + "organization", + "respectively", + "metals", + "interior", + "influence", + "thus", + "residues", + "bind", + "basis", + "bound", "sites", + "proteins", + "packing", + "characterization", + "ions", + "19", + "use", + "may", + "iii", + "coils", + "peptide", + "forming", + "heptad", + "lack", + "speculate", + "spectroscopic", + "behavior", + "used", "past", - "chains", + "yet", + "assembly", + "nonmetalated", "cysteine", - "one", - "fundamental", - "clarify", - "lack", "complexation", - "novo", - "single", - "leucines", - "csl19c", - "speculate", - "understand", - "peptides", - "insight", - "residues", - "two", - "cys", - "examples", - "binding", - "protein", - "bound", + "9", + "decades", + "glu", + "realized", + "metalated", + "time", + "parallel", "resolutions", - "variety", - "interior", - "differences", "types", - "understanding", "csl9c", - "side", - "site", - "forms", + "peptides", "crystals", - "whereas" + "present", + "whereas", + "versus", + "exist", + "fundamental", + "designed", + "interfaces", + "one", + "observed", + "structures", + "de", + "constructs", + "ser", + "suitable", + "understand", + "first", + "3", + "differential", + "conformer", + "structure", + "scaffolds", + "replaced", + "alternate", + "determined", + "provide", + "herein", + "coordinate", + "crystallography", + "understanding", + "cysteines", + "examples", + "cys", + "coiled", + "coil", + "ultimately", + "preorganized", + "conformations", + "position", + "data", + "reports", + "quality", + "held", + "inherent", + "generate", + "metalloregulatory", + "ii" ], "release_date":"2010-09-22", "publication":"\"Structural Comparisons of Apo- and Metalated Three-Stranded Coiled Coils Clarify Metal Binding Determinants in Thiolate Containing Designed Peptides\", J.Am.Chem.Soc., 132, 13240", @@ -37404,19 +37426,19 @@ "seq_thr_sim_designed":[ { "sim":51.0, - "partner":"5u9u" + "partner":"2jgo" }, { "sim":51.0, - "partner":"5k92" + "partner":"5u9t" }, { "sim":51.0, - "partner":"2jgo" + "partner":"5k92" }, { "sim":51.0, - "partner":"5u9t" + "partner":"5u9u" } ], "seq_thr_sim_natural":[ @@ -37435,10 +37457,6 @@ "sim":0.993900001, "partner":"5u9t" }, - { - "sim":0.996900022, - "partner":"5u9u" - }, { "sim":0.9592000246, "partner":"3h5f" @@ -37447,6 +37465,10 @@ "sim":0.9548000097, "partner":"3h5g" }, + { + "sim":0.996900022, + "partner":"5u9u" + }, { "sim":0.9970999956, "partner":"2jgo" @@ -37473,11 +37495,19 @@ }, { "sim":1.0, - "partner":"6v5j" + "partner":"6v5i" }, { "sim":1.0, - "partner":"6v5i" + "partner":"6v5j" + }, + { + "sim":0.9965999722, + "partner":"6u47" + }, + { + "sim":0.9552000165, + "partner":"5kb0" }, { "sim":1.0, @@ -37488,8 +37518,8 @@ "partner":"6ovs" }, { - "sim":0.9965999722, - "partner":"6u47" + "sim":0.9983000159, + "partner":"6q25" }, { "sim":1.0, @@ -37500,12 +37530,16 @@ "partner":"6v4y" }, { - "sim":0.9983000159, - "partner":"6q25" + "sim":0.9617000222, + "partner":"6ov9" + }, + { + "sim":0.959100008, + "partner":"1coi" }, { "sim":0.9617000222, - "partner":"6ovv" + "partner":"6v57" }, { "sim":0.9617000222, @@ -37517,7 +37551,11 @@ }, { "sim":0.9617000222, - "partner":"6ov9" + "partner":"6ovv" + }, + { + "sim":0.9617000222, + "partner":"6q22" }, { "sim":0.9535999894, @@ -37539,25 +37577,9 @@ "sim":0.9934999943, "partner":"3r3k" }, - { - "sim":0.959100008, - "partner":"1coi" - }, - { - "sim":0.9552000165, - "partner":"5kb0" - }, { "sim":0.9578999877, "partner":"7n2z" - }, - { - "sim":0.9617000222, - "partner":"6v57" - }, - { - "sim":0.9617000222, - "partner":"6q22" } ], "struct_thr_sim_natural":[ @@ -37565,7 +37587,7 @@ ], "seq_max_sim_designed":{ "sim":51.0, - "partner":"5u9u" + "partner":"2jgo" }, "seq_max_sim_natural":[ @@ -37625,113 +37647,113 @@ ], "subtitle":"Structural determinants for improved thermal stability of designed ankyrin repeat proteins with a redesigned c-capping module", "tags":[ - "protein engineering", + "protein-protein interaction", "de novo protein", - "protein-protein interaction" + "protein engineering" ], "keywords":[ - "unfolding", - "results", - "change", - "studies", - "coupling", - "already", + "superior", + "repeats", + "molecular", + "complementarity", + "structural", + "additional", + "repeat", + "show", "spaced", - "designed", - "carrying", - "mutations", - "towards", - "improved", + "three", + "explains", + "extended", + "ni", + "results", + "protein", + "increased", + "salt", + "unfolding", + "showed", + "equilibrium", + "charged", + "original", + "recent", "crystal", - "determined", - "target", - "show", + "stable", + "using", + "simulations", + "ribosome", + "taken", + "initial", + "limits", + "almost", + "bridges", + "residues", + "family", + "although", + "buried", "denaturation", "bind", - "suggested", - "equilibrium", - "c", - "display", - "repeat", - "optimize", - "explaining", - "original", + "stability", "proteins", + "mutants", + "several", + "consensus", + "ankyrin", + "coupling", "combinatorial", - "specifically", - "although", - "family", - "area", - "almost", - "point", - "indeed", "interface", - "initial", - "3", - "dynamics", - "structures", - "buried", - "charged", - "natural", - "capping", - "three", - "showed", - "ni", - "mutants", - "additional", - "compared", - "molecules", - "consensus", - "previously", - "stability", - "salt", - "obtained", - "taken", - "molecular", - "guide", - "phage", - "complementarity", - "underline", - "extended", - "bridges", - "increased", - "darpins", - "1", + "carrying", "mutant", - "limits", - "movement", - "shown", - "simulations", - "help", - "several", "introduced", + "importance", + "1", + "increase", + "obtained", + "c", + "preceding", + "surface", "design", + "already", + "indeed", + "compared", + "movement", + "help", + "natural", + "display", + "experiments", + "point", + "shown", "reduced", - "using", + "improved", + "formation", "suitably", - "nmr", - "surface", - "recent", + "underline", "sequence", - "repeats", - "increase", + "suggested", + "darpins", + "optimize", + "dynamics", + "designed", "introducing", - "formation", - "structural", - "importance", "one", - "stable", - "libraries", - "ribosome", - "experiments", - "explains", - "ankyrin", - "residues", + "mutations", + "structures", + "3", + "previously", + "area", "darpin", - "preceding", - "protein", - "superior", + "specifically", + "determined", + "target", + "nmr", + "capping", "internal", + "molecules", + "phage", + "change", + "towards", + "explaining", + "guide", + "libraries", + "studies", "five" ], "release_date":"2010-08-18", @@ -37777,15 +37799,15 @@ }, { "sim":270.0, - "partner":"7b4t" + "partner":"6fpb" }, { "sim":270.0, - "partner":"6fpb" + "partner":"6fpa" }, { "sim":270.0, - "partner":"6fpa" + "partner":"7b4t" }, { "sim":266.0, @@ -37805,11 +37827,11 @@ }, { "sim":261.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":261.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":261.0, @@ -37881,19 +37903,19 @@ }, { "sim":246.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":246.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":246.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":246.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":246.0, @@ -37901,35 +37923,35 @@ }, { "sim":246.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":246.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":246.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":246.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":246.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":246.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":246.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":246.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":246.0, @@ -37989,7 +38011,7 @@ }, { "sim":233.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":233.0, @@ -37997,7 +38019,7 @@ }, { "sim":233.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":232.0, @@ -38021,11 +38043,11 @@ }, { "sim":229.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":229.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":229.0, @@ -38061,11 +38083,11 @@ }, { "sim":198.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":198.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":198.0, @@ -38119,6 +38141,10 @@ "sim":180.0, "partner":"8aiw" }, + { + "sim":178.0, + "partner":"9glq" + }, { "sim":178.0, "partner":"5hs0" @@ -38583,113 +38609,113 @@ ], "subtitle":"Structural determinants for improved thermal stability of designed ankyrin repeat proteins with a redesigned c-capping module", "tags":[ - "protein engineering", + "protein-protein interaction", "de novo protein", - "protein-protein interaction" + "protein engineering" ], "keywords":[ - "unfolding", - "results", - "change", - "studies", - "coupling", - "already", - "spaced", - "designed", - "carrying", - "mutations", - "towards", - "improved", - "crystal", - "determined", - "target", + "superior", + "repeats", + "molecular", + "complementarity", + "structural", + "additional", + "repeat", "show", - "denaturation", - "bind", - "suggested", + "spaced", + "three", + "explains", + "extended", + "ni", + "results", + "protein", + "increased", + "salt", + "unfolding", + "showed", "equilibrium", - "c", - "display", - "repeat", - "optimize", - "explaining", + "charged", "original", - "proteins", - "combinatorial", - "specifically", - "although", - "family", - "area", - "almost", - "point", - "indeed", - "interface", + "recent", + "crystal", + "stable", + "using", + "simulations", + "ribosome", + "taken", "initial", - "3", - "dynamics", - "structures", + "limits", + "almost", + "bridges", + "residues", + "family", + "although", "buried", - "charged", - "natural", - "capping", - "three", - "showed", - "ni", + "denaturation", + "bind", + "stability", + "proteins", "mutants", - "additional", - "compared", - "molecules", + "several", "consensus", - "previously", - "stability", - "salt", - "obtained", - "taken", - "molecular", - "guide", - "phage", - "complementarity", - "underline", - "extended", - "bridges", - "increased", - "darpins", - "1", + "ankyrin", + "coupling", + "combinatorial", + "interface", + "carrying", "mutant", - "limits", - "movement", - "shown", - "simulations", - "help", - "several", "introduced", + "importance", + "1", + "increase", + "obtained", + "c", + "preceding", + "surface", "design", + "already", + "indeed", + "compared", + "movement", + "help", + "natural", + "display", + "experiments", + "point", + "shown", "reduced", - "using", + "improved", + "formation", "suitably", - "nmr", - "surface", - "recent", + "underline", "sequence", - "repeats", - "increase", + "suggested", + "darpins", + "optimize", + "dynamics", + "designed", "introducing", - "formation", - "structural", - "importance", "one", - "stable", - "libraries", - "ribosome", - "experiments", - "explains", - "ankyrin", - "residues", + "mutations", + "structures", + "3", + "previously", + "area", "darpin", - "preceding", - "protein", - "superior", + "specifically", + "determined", + "target", + "nmr", + "capping", "internal", + "molecules", + "phage", + "change", + "towards", + "explaining", + "guide", + "libraries", + "studies", "five" ], "release_date":"2010-08-18", @@ -38735,15 +38761,15 @@ }, { "sim":262.0, - "partner":"7b4t" + "partner":"6fpb" }, { "sim":262.0, - "partner":"6fpb" + "partner":"6fpa" }, { "sim":262.0, - "partner":"6fpa" + "partner":"7b4t" }, { "sim":258.0, @@ -38767,11 +38793,11 @@ }, { "sim":253.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":253.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":252.0, @@ -38839,19 +38865,19 @@ }, { "sim":238.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":238.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":238.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":238.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":238.0, @@ -38859,35 +38885,35 @@ }, { "sim":238.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":238.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":238.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":238.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":238.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":238.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":238.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":238.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":238.0, @@ -38955,7 +38981,7 @@ }, { "sim":226.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":226.0, @@ -38963,7 +38989,7 @@ }, { "sim":226.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":225.0, @@ -38991,11 +39017,11 @@ }, { "sim":221.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":221.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":221.0, @@ -39031,11 +39057,11 @@ }, { "sim":190.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":190.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":190.0, @@ -39065,6 +39091,10 @@ "sim":180.0, "partner":"5eil" }, + { + "sim":178.0, + "partner":"9glq" + }, { "sim":178.0, "partner":"9f23" @@ -39173,15 +39203,15 @@ }, { "sim":104.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":104.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":104.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":103.0, @@ -39513,116 +39543,116 @@ ], "subtitle":"Structural determinants for improved thermal stability of designed ankyrin repeat proteins with a redesigned c-capping module", "tags":[ - "design", - "protein engineering", + "protein-protein interaction", "de novo protein", + "design", "ankyrin", - "protein-protein interaction", + "protein engineering", "repeat protein" ], "keywords":[ - "unfolding", - "results", - "change", - "studies", - "coupling", - "already", - "spaced", - "designed", - "carrying", - "mutations", - "towards", - "improved", - "crystal", - "determined", - "target", + "superior", + "repeats", + "molecular", + "complementarity", + "structural", + "additional", + "repeat", "show", - "denaturation", - "bind", - "suggested", + "spaced", + "three", + "explains", + "extended", + "ni", + "results", + "protein", + "increased", + "salt", + "unfolding", + "showed", "equilibrium", - "c", - "display", - "repeat", - "optimize", - "explaining", + "charged", "original", - "proteins", - "combinatorial", - "specifically", - "although", - "family", - "area", - "almost", - "point", - "indeed", - "interface", + "recent", + "crystal", + "stable", + "using", + "simulations", + "ribosome", + "taken", "initial", - "3", - "dynamics", - "structures", + "limits", + "almost", + "bridges", + "residues", + "family", + "although", "buried", - "charged", - "natural", - "capping", - "three", - "showed", - "ni", + "denaturation", + "bind", + "stability", + "proteins", "mutants", - "additional", - "compared", - "molecules", + "several", "consensus", - "previously", - "stability", - "salt", - "obtained", - "taken", - "molecular", - "guide", - "phage", - "complementarity", - "underline", - "extended", - "bridges", - "increased", - "darpins", - "1", + "ankyrin", + "coupling", + "combinatorial", + "interface", + "carrying", "mutant", - "limits", - "movement", - "shown", - "simulations", - "help", - "several", "introduced", + "importance", + "1", + "increase", + "obtained", + "c", + "preceding", + "surface", "design", + "already", + "indeed", + "compared", + "movement", + "help", + "natural", + "display", + "experiments", + "point", + "shown", "reduced", - "using", + "improved", + "formation", "suitably", - "nmr", - "surface", - "recent", + "underline", "sequence", - "repeats", - "increase", + "suggested", + "darpins", + "optimize", + "dynamics", + "designed", "introducing", - "formation", - "structural", - "importance", "one", - "stable", - "libraries", - "ribosome", - "experiments", - "explains", - "ankyrin", - "residues", + "mutations", + "structures", + "3", + "previously", + "area", "darpin", - "preceding", - "protein", - "superior", + "specifically", + "determined", + "target", + "nmr", + "capping", "internal", + "molecules", + "phage", + "change", + "towards", + "explaining", + "guide", + "libraries", + "studies", "five" ], "release_date":"2010-08-18", @@ -39660,11 +39690,11 @@ }, { "sim":145.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":145.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":144.0, @@ -39700,11 +39730,11 @@ }, { "sim":138.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":138.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":135.0, @@ -39740,11 +39770,11 @@ }, { "sim":132.0, - "partner":"5oos" + "partner":"5op3" }, { "sim":132.0, - "partner":"5op3" + "partner":"5oos" }, { "sim":132.0, @@ -39760,19 +39790,19 @@ }, { "sim":131.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":131.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":131.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":131.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":131.0, @@ -39780,35 +39810,35 @@ }, { "sim":131.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":131.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":131.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":131.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":131.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":131.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":131.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":131.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":130.0, @@ -39888,11 +39918,11 @@ }, { "sim":125.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":125.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":125.0, @@ -39932,7 +39962,7 @@ }, { "sim":123.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":123.0, @@ -39940,7 +39970,7 @@ }, { "sim":123.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":123.0, @@ -39950,6 +39980,10 @@ "sim":122.0, "partner":"8aiw" }, + { + "sim":122.0, + "partner":"9glq" + }, { "sim":122.0, "partner":"6fes" @@ -39996,7 +40030,7 @@ }, { "sim":96.0, - "partner":"5kba" + "partner":"4hb5" }, { "sim":96.0, @@ -40004,7 +40038,7 @@ }, { "sim":96.0, - "partner":"4hb5" + "partner":"5kba" }, { "sim":93.0, @@ -40276,61 +40310,61 @@ "leucine zipper" ], "keywords":[ - "distinctive", - "layer", - "coiled", - "make", - "angstrom", - "helices", - "also", - "resolution", + "leucine", + "leucines", "handshake", + "yeast", + "angstrom", + "shows", + "role", + "hydrophobic", "conserved", - "leucines", - "peptide", - "crick", - "interface", - "residues", - "proposed", + "resolution", + "packed", + "repeat", + "key", + "1953", "suggests", + "include", + "every", "dimer", - "activator", - "parallel", - "gcn4", - "crystal", - "leucine", - "transcriptional", + "crick", + "contribute", + "residues", + "structure", + "alternate", "determined", - "contains", - "include", - "like", - "features", + "make", + "also", "model", + "layer", + "ion", "interactions", - "bond", - "packed", - "alternate", - "hydrophobic", - "corresponding", - "structure", - "pairs", - "zipper", - "repeat", + "contacts", + "transcriptional", "alpha", - "coil", - "key", "formation", - "1953", - "yeast", + "gcn4", + "coiled", "extensive", - "shows", - "role", - "contribute", + "contains", "hydrogen", + "parallel", + "coil", + "interface", "forms", - "contacts", - "ion", - "every" + "bond", + "zipper", + "activator", + "crystal", + "distinctive", + "helices", + "features", + "proposed", + "like", + "corresponding", + "pairs", + "peptide" ], "release_date":"1992-10-15", "publication":"\"X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil\", Science, 254, 539-544", @@ -40433,97 +40467,97 @@ ], "subtitle":"Designed peptide alpha-1, racemic p1bar form", "tags":[ - "helical bilayer", "structural protein", - "biomaterial", "racemic", - "centric" + "centric", + "helical bilayer", + "biomaterial" ], "keywords":[ - "equivalent", - "analysis", - "restricted", - "peptide", - "designed", - "near", - "contains", - "crystal", - "determined", - "bind", - "structure", - "allowed", - "building", - "body", - "direct", - "discrete", - "composed", - "chain", - "cell", - "enantiomer", - "solutions", - "although", + "resolution", + "ethanolamine", + "neighboring", + "side", + "phasing", + "intricate", "centrosymmetric", - "sheet", - "paper", - "seen", - "small", - "maintained", - "rigid", + "model", + "rfree", + "insight", + "torsion", "motif", - "disorder", - "bilayer", - "sheets", + "incorporates", + "inversion", + "composed", "except", + "body", + "two", + "related", + "crystal", + "helices", + "asymmetric", + "disorder", + "torsions", "mixture", - "bilayers", "r", - "phasing", - "solvent", - "much", - "molecules", - "inversion", - "rfree", - "report", - "resolution", - "asymmetric", + "mpd", + "helix", + "bilayers", + "rigid", + "although", + "environments", + "bind", + "propagates", + "sites", + "described", + "contains", + "small", + "restrict", + "p1", + "bilayer", + "termini", + "displacements", + "restricted", + "peptide", + "discrete", + "direct", "programs", + "symmetry", + "design", + "chain", "active", - "unit", "provides", - "displacements", - "comparison", - "design", - "model", - "incorporates", - "symmetry", - "torsion", - "high", - "identifies", - "ethanolamine", - "torsions", - "racemic", - "restrict", - "sites", - "one", - "p1bar", + "maintained", + "equivalent", "groups", - "helices", - "described", - "insight", - "neighboring", - "propagates", - "two", - "intricate", - "environments", - "termini", - "mpd", + "seen", + "cell", + "sheets", "backbone", + "building", + "near", + "paper", + "p1bar", + "designed", + "analysis", "space", - "helix", + "one", + "allowed", + "structure", + "report", + "solutions", + "determined", + "sheet", + "unit", + "racemic", + "molecules", + "high", "accompanying", - "p1", - "side", - "related" + "much", + "solvent", + "identifies", + "enantiomer", + "comparison" ], "release_date":"1998-11-04", "publication":"\"Centrosymmetric bilayers in the 0.75 A resolution structure of a designed alpha-helical peptide, D,L-Alpha-1\", Protein Sci., 8, 1410-1422", @@ -40626,128 +40660,128 @@ "subtitle":"Crystal structure of lipopeptide detergent (lpd-12)", "tags":[ "amphiphilic", - "detergent", - "self-assembling peptide", "de novo protein", + "self-assembling peptide", "alpha helix", "lipopeptide", - "acyl chains" + "acyl chains", + "detergent" ], "keywords":[ - "containing", + "dimers", + "engineering", + "molecular", + "adopt", + "hydrophobic", + "structural", + "resolution", + "additional", + "cavity", "ordered", + "side", + "dodecylmaltoside", + "framework", + "dihedral", + "new", + "aligned", + "lipopeptide", + "helpful", + "study", + "micelles", + "positions", + "acyl", + "weight", + "expected", + "major", + "two", "confirm", - "located", - "amphiphiles", - "providing", - "amphiphile", - "peptide", - "designed", - "exterior", - "cylindrical", - "shell", - "interact", "crystal", - "determined", - "target", - "find", - "features", - "fatty", - "lipopeptide", + "shell", + "helices", + "chains", "conformation", - "adopt", - "visible", - "structure", - "16", - "monomer", + "antiparallel", + "lpd", + "detergents", + "interior", + "fatty", + "overall", + "relative", "hydrophilic", - "objectives", - "conformations", + "dodecanoic", + "strongly", "contacts", - "associate", + "interact", + "proteins", + "packing", + "2", + "exterior", "acylated", - "chain", + "monomer", "interiors", - "membrane", - "proteins", - "specifically", - "strongly", - "detergents", - "trans", - "resulting", - "kda", - "cavity", - "helpful", - "structures", - "positions", - "30", - "natural", - "dihedral", + "linked", + "four", + "features", + "24", + "required", "pairs", + "peptide", + "cylindrical", + "consists", + "symmetry", + "design", + "chain", + "visible", "ddm", - "linked", + "30", + "natural", + "associate", + "amphiphile", + "environment", + "monomers", + "16", + "approximately", "assembly", + "groups", + "amphiphiles", + "kda", + "approximate", + "90", + "angle", + "trans", + "assemblies", + "associated", + "versions", + "reveal", + "designed", "form", - "additional", "coupled", - "molecules", - "much", "protects", + "octamers", + "providing", + "structures", + "traditional", + "integral", + "lpds", + "specifically", "crystallization", - "framework", - "versions", - "monomers", - "looser", - "unexpected", - "molecular", - "expected", - "associated", - "lpd", - "dodecylmaltoside", - "assemblies", - "acyl", - "resolution", + "structure", + "determined", + "resulting", + "target", + "membrane", + "micelle", "class", - "four", + "molecules", + "find", + "located", + "much", "acids", - "aligned", - "engineering", - "design", - "weight", - "lpds", - "approximate", - "hydrophobic", - "required", - "symmetry", - "micelles", - "packing", - "structural", - "integral", - "angle", - "overall", - "chains", - "groups", - "helices", - "octamers", - "study", - "90", - "reveal", - "dodecanoic", - "two", - "dimers", - "antiparallel", - "approximately", - "24", - "2", - "interior", - "micelle", - "environment", - "consists", - "major", - "side", - "relative", - "traditional", - "new" + "conformations", + "unexpected", + "containing", + "looser", + "objectives" ], "release_date":"2008-09-09", "publication":"\"Crystal structure of a self-assembling lipopeptide detergent at 1.20 A\", Proc.Natl.Acad.Sci.USA, 105, 12861-12866", @@ -40841,50 +40875,50 @@ ], "subtitle":"Switching the chirality of the metal environment alters the coordination mode in designed peptides", "tags":[ - "de-novo protein", "de novo protein", "l-penicillamine", - "parallel three-stranded coiled coil" + "parallel three-stranded coiled coil", + "de-novo protein" ], "keywords":[ + "designed", "spectroscopic", - "layer", "modification", - "coiled", + "metal", "enantiomers", - "chirality", - "evidence", - "amino", - "studies", - "reveals", - "coordination", "investigated", - "single", "cadmium", - "contrast", - "metal", - "crystallography", - "acids", - "designed", - "dramatically", + "capability", "well", - "switch", - "resulting", + "single", + "alters", + "environment", + "three", + "structure", "provide", - "switching", + "resulting", + "chirality", + "layer", + "crystallography", + "amino", "penicillamine", + "binding", + "evidence", + "switching", + "dramatically", + "coiled", + "contrast", + "coordination", "alter", - "tolerated", - "alters", - "position", - "capability", - "structure", - "three", - "environment", "coil", + "reveals", + "acids", + "switch", + "studies", + "position", "effects", "stranded", - "binding" + "tolerated" ], "release_date":"2009-07-14", "publication":"\"Switching the Chirality of the Metal Environment Alters the Coordination Mode in Designed Peptides\", Angew.Chem.Int.Ed.Engl., 48, 7371-7374", @@ -41070,50 +41104,50 @@ ], "subtitle":"Switching the chirality of the metal environment alters the coordination mode in designed peptides", "tags":[ - "de-novo protein", "de novo protein", - "d-penicillamine", - "parallel three-stranded coiled coil" + "parallel three-stranded coiled coil", + "de-novo protein", + "d-penicillamine" ], "keywords":[ + "designed", "spectroscopic", - "layer", "modification", - "coiled", + "metal", "enantiomers", - "chirality", - "evidence", - "amino", - "studies", - "reveals", - "coordination", "investigated", - "single", "cadmium", - "contrast", - "metal", - "crystallography", - "acids", - "designed", - "dramatically", + "capability", "well", - "switch", - "resulting", + "single", + "alters", + "environment", + "three", + "structure", "provide", - "switching", + "resulting", + "chirality", + "layer", + "crystallography", + "amino", "penicillamine", + "binding", + "evidence", + "switching", + "dramatically", + "coiled", + "contrast", + "coordination", "alter", - "tolerated", - "alters", - "position", - "capability", - "structure", - "three", - "environment", "coil", + "reveals", + "acids", + "switch", + "studies", + "position", "effects", "stranded", - "binding" + "tolerated" ], "release_date":"2009-07-14", "publication":"\"Switching the Chirality of the Metal Environment Alters the Coordination Mode in Designed Peptides\", Angew.Chem.Int.Ed.Engl., 48, 7371-7374", @@ -41311,92 +41345,92 @@ "heterodimeric coiled-coil" ], "keywords":[ - "many", - "details", - "undesired", - "peptide", - "geometries", - "provide", - "complete", "limited", - "versatile", - "interactions", - "synthetic", - "expand", - "dimerize", - "opportunity", - "measuring", - "networks", - "screen", - "combinations", - "heteroassociate", - "interaction", - "without", - "coiled", + "molecular", "7", - "induce", + "structural", + "crosstalk", + "bzip", + "details", + "new", "interactome", + "protein", "network", - "proteins", - "greatly", - "6", - "resulting", - "used", - "yet", + "topologies", "motif", - "materials", + "pair", + "networks", "heterospecific", + "systems", + "motifs", "27", - "3", - "assemble", - "compose", - "includes", + "two", + "applications", + "special", + "participate", + "using", + "induce", + "separate", + "interacting", + "interest", "macromolecular", - "widely", - "coils", - "pairs", - "solution", - "biology", - "motifs", - "preferentially", - "systems", "discovered", - "special", + "widely", "control", - "molecular", - "pairwise", "orthogonal", - "topologies", - "interacting", - "interest", - "crosstalk", - "mutually", - "microarrays", + "constructed", + "proteins", + "includes", "characterization", - "using", - "applications", - "separate", - "known", - "structural", - "capabilities", - "patterns", - "toolkit", - "sets", + "compose", "along", - "human", - "participate", - "peptides", - "constructed", + "coils", + "pairs", + "peptide", "science", - "bzip", - "two", - "heterodimers", - "protein", - "types", + "geometries", + "toolkit", + "heteroassociate", + "used", + "biology", + "yet", + "dimerize", + "combinations", + "undesired", + "complete", + "solution", + "interaction", "varying", + "types", + "versatile", + "expand", + "peptides", + "capabilities", + "materials", + "mutually", + "heterodimers", + "many", + "6", + "pairwise", + "3", "48", - "pair", - "new" + "screen", + "without", + "synthetic", + "preferentially", + "provide", + "resulting", + "interactions", + "patterns", + "known", + "measuring", + "greatly", + "coiled", + "microarrays", + "assemble", + "human", + "opportunity", + "sets" ], "release_date":"2010-03-23", "publication":"\"A synthetic coiled-coil interactome provides heterospecific modules for molecular engineering\", J.Am.Chem.Soc., 132, 6025-6031", @@ -41504,92 +41538,92 @@ "heterodimeric coiled-coil" ], "keywords":[ - "many", - "details", - "undesired", - "peptide", - "geometries", - "provide", - "complete", "limited", - "versatile", - "interactions", - "synthetic", - "expand", - "dimerize", - "opportunity", - "measuring", - "networks", - "screen", - "combinations", - "heteroassociate", - "interaction", - "without", - "coiled", + "molecular", "7", - "induce", + "structural", + "crosstalk", + "bzip", + "details", + "new", "interactome", + "protein", "network", - "proteins", - "greatly", - "6", - "resulting", - "used", - "yet", + "topologies", "motif", - "materials", + "pair", + "networks", "heterospecific", + "systems", + "motifs", "27", - "3", - "assemble", - "compose", - "includes", + "two", + "applications", + "special", + "participate", + "using", + "induce", + "separate", + "interacting", + "interest", "macromolecular", - "widely", - "coils", - "pairs", - "solution", - "biology", - "motifs", - "preferentially", - "systems", "discovered", - "special", + "widely", "control", - "molecular", - "pairwise", "orthogonal", - "topologies", - "interacting", - "interest", - "crosstalk", - "mutually", - "microarrays", + "constructed", + "proteins", + "includes", "characterization", - "using", - "applications", - "separate", - "known", - "structural", - "capabilities", - "patterns", - "toolkit", - "sets", + "compose", "along", - "human", - "participate", - "peptides", - "constructed", + "coils", + "pairs", + "peptide", "science", - "bzip", - "two", - "heterodimers", - "protein", - "types", + "geometries", + "toolkit", + "heteroassociate", + "used", + "biology", + "yet", + "dimerize", + "combinations", + "undesired", + "complete", + "solution", + "interaction", "varying", + "types", + "versatile", + "expand", + "peptides", + "capabilities", + "materials", + "mutually", + "heterodimers", + "many", + "6", + "pairwise", + "3", "48", - "pair", - "new" + "screen", + "without", + "synthetic", + "preferentially", + "provide", + "resulting", + "interactions", + "patterns", + "known", + "measuring", + "greatly", + "coiled", + "microarrays", + "assemble", + "human", + "opportunity", + "sets" ], "release_date":"2010-03-23", "publication":"\"A synthetic coiled-coil interactome provides heterospecific modules for molecular engineering\", J.Am.Chem.Soc., 132, 6025-6031", @@ -41725,59 +41759,59 @@ ], "subtitle":"Crystal structure of a novel engineered diels-alderase: da_20_00_a74i", "tags":[ + "hydrolase", "metal-binding", - "beta-propeller", - "hydrolase" + "beta-propeller" ], "keywords":[ - "cornerstone", - "one", - "matches", + "designed", "chemistry", + "reaction", + "stereogenic", + "naturally", + "design", + "organic", + "one", "specificity", - "bonds", - "stereoselectivity", + "reactions", + "active", + "bimolecular", "de", - "novo", - "enzymes", - "catalysts", - "four", "experimental", - "crystallography", - "reactions", - "designed", "substrate", - "reaction", - "active", - "useful", + "stereoselectivity", + "step", "substitutions", - "shown", + "structure", "synthesis", - "two", - "step", - "site", - "occurring", - "organic", - "confirms", - "catalyze", - "design", - "forming", + "synthetic", + "bonds", + "new", + "matches", + "crystallography", + "useful", + "shown", + "binding", "characterization", + "confirms", + "enzymes", + "site", + "novo", "centers", - "naturally", - "synthetic", - "stereoselective", - "catalyzing", - "reprogram", - "describe", - "stereogenic", "high", - "bimolecular", - "structure", "broadly", + "two", + "cornerstone", + "describe", + "four", + "stereoselective", "computational", - "binding", - "new" + "reprogram", + "catalyzing", + "forming", + "catalysts", + "occurring", + "catalyze" ], "release_date":"2009-08-18", "publication":"\"Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction\", Science, 329, 309-313", @@ -41898,85 +41932,85 @@ ], "subtitle":"Structural plasticity of helical nanotubes based on coiled-coil assemblies", "tags":[ - "coiled-coil", "nanotube", "helical filament", + "coiled-coil", "synthetic peptide" ], "keywords":[ - "framework", + "designed", + "achieve", "supramolecular", - "evolution", + "divergence", + "path", "taken", - "remained", + "design", + "sequences", + "however", + "conserved", + "structural", + "capability", + "resolution", "one", - "amino", - "newly", - "available", - "large", - "assemblies", - "changes", + "show", + "phenomenon", + "provides", + "structures", + "translate", "de", - "novo", - "resolution", - "divergence", - "conserved", - "detection", - "peptide", + "instances", + "different", + "based", + "newly", + "cryomicroscopy", + "structure", + "synthetic", + "framework", + "nanotubes", + "fairly", "place", - "peptides", - "designed", - "acids", - "electron", - "may", + "quaternary", "seen", - "different", - "small", - "translate", - "instances", - "two", - "motif", - "system", + "usually", + "conservative", + "protein", + "amino", + "understanding", + "known", + "blocks", + "helical", "vitro", + "electron", + "changes", + "dramatic", + "large", + "remained", + "motif", "thin", - "diverged", - "blocks", - "result", - "provides", - "based", - "show", - "implications", - "sequences", - "design", "spontaneously", - "helical", - "structures", - "protein", - "numerous", - "synthetic", - "using", - "phenomenon", + "may", + "novo", "significant", - "path", - "capability", - "structure", "sequence", - "dramatic", - "switched", - "understanding", - "usually", "building", - "fairly", - "quaternary", - "however", - "known", - "achieve", - "cryomicroscopy", - "structural", - "conservative", + "system", + "small", + "available", + "switched", + "peptides", + "acids", + "result", "forms", - "direct", - "nanotubes" + "numerous", + "two", + "evolution", + "implications", + "diverged", + "peptide", + "assemblies", + "using", + "detection", + "direct" ], "release_date":"2015-02-11", "publication":"\"Structural plasticity of helical nanotubes based on coiled-coil assemblies\", Structure, 23, 280-289", @@ -42084,83 +42118,83 @@ ], "subtitle":"Designed tpr module (ctpr390) in complex with its peptide-ligand (hsp90 peptide)", "tags":[ - "tpr-ligand complex", "superhelical structure", - "hsp90 binding", + "tetratricopeptide repeat (tpr)", "de novo protein", + "hsp90 binding", + "tpr-ligand complex", "designed protein", - "tetratricopeptide repeat (tpr)", "repeat protein" ], "keywords":[ - "exchange", - "domain", - "ligand", + "designed", + "repeats", + "partners", "ctpr390", + "complex", + "shock", + "form", "molecular", - "arrangement", + "meevd", + "design", + "recognition", + "insights", + "vivo", + "interesting", "tprs", + "key", + "hsp", + "tpr", + "able", + "observed", + "provides", + "inhibit", + "first", + "previously", + "domain", + "ligand", "chaperone", - "reveals", - "aspects", "specifically", - "described", - "inhibit", - "modules", - "response", - "stack", - "90", - "peptide", - "designed", "residues", - "interesting", - "recognition", - "binds", - "two", - "tetratricopeptide", - "infinite", - "crystal", + "structure", "new", - "provides", - "domains", - "several", - "observed", - "design", - "previously", - "units", - "partners", - "tpr", - "basis", - "protein", "interactions", - "bind", - "chaperones", - "present", - "complex", - "hsp90", + "protein", "superhelices", - "hsp70", + "bind", "function", - "structure", - "repeats", "tightly", - "unusual", - "insights", - "vivo", - "key", + "infinite", + "basis", + "response", + "modules", + "tetratricopeptide", + "binding", + "packing", "mediate", - "heat", - "shock", - "able", + "several", "fashion", + "described", + "units", + "hsp70", "cells", - "form", - "first", + "domains", + "hsp90", + "90", + "chaperones", + "arrangement", + "reveals", + "exchange", + "stack", + "two", + "aspects", + "present", + "heat", + "crystal", + "binds", + "unusual", "second", - "packing", - "binding", - "meevd", - "hsp" + "peptide" ], "release_date":"2010-02-02", "publication":"\"Crystal structure of a designed tetratricopeptide repeat module in complex with its peptide ligand\", Febs J., 277, 1058-1066", @@ -42335,79 +42369,79 @@ "epitope-scaffold" ], "keywords":[ - "immunogenic", - "neutralization", - "general", - "toward", - "demonstrate", + "designed", + "inhibited", + "design", "poorly", - "valuable", - "predetermined", - "results", - "viruses", - "proteins", - "available", - "rabbit", - "exhibited", "conformational", + "cognate", + "immunogenic", + "monoclonal", + "development", + "structural", "immunogens", - "higher", + "transplanted", + "presentation", + "methods", + "conserved", + "translate", + "structures", "complexes", - "similar", + "exhibited", + "elicitation", "mimicry", - "sera", + "information", + "4e10", + "computationally", + "define", + "epitopes", + "immunization", + "important", + "results", "specificity", - "advance", - "neutralizing", - "antibody", - "conserved", - "hiv", + "viruses", "reagents", - "peptide", - "define", - "information", - "method", - "presentation", - "designed", - "cognate", - "translate", "immune", - "highly", - "needed", - "induced", - "affinities", - "transplanted", - "activity", "mab", - "methods", - "crystal", - "immunization", - "scaffold", - "several", - "design", - "4e10", "mutable", - "structures", - "contiguous", + "hiv", + "serological", "bound", - "development", - "describe", - "high", + "proteins", + "sera", + "valuable", + "stabilization", + "several", "elicit", - "epitopes", + "general", + "contiguous", + "high", + "activity", "broadly", - "monoclonal", + "scaffold", + "highly", + "neutralization", + "demonstrate", + "available", + "neutralizing", + "toward", + "predetermined", + "induced", + "crystal", + "higher", "vaccine", + "describe", + "affinities", + "method", + "rabbit", "computational", - "computationally", + "advance", "epitope", + "similar", + "peptide", "antibodies", - "serological", - "inhibited", - "structural", - "important", - "elicitation", - "stabilization" + "antibody", + "needed" ], "release_date":"2010-09-22", "publication":"\"Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope\", Structure, 18, 1116-1126", @@ -42462,19 +42496,19 @@ }, { "sim":104.0, - "partner":"2rdo" + "partner":"1ek8" }, { "sim":104.0, - "partner":"1zn1" + "partner":"1zn0" }, { "sim":104.0, - "partner":"1ek8" + "partner":"2rdo" }, { "sim":104.0, - "partner":"1zn0" + "partner":"1zn1" }, { "sim":71.0, @@ -42551,155 +42585,155 @@ ], "subtitle":"Structure of de novo designed apo peptide coil ser l9c", "tags":[ - "three stranded coiled coil", "de novo protein", "apo", - "de novo design" + "de novo design", + "three stranded coiled coil" ], "keywords":[ - "reports", - "constructs", - "heptad", - "herein", - "thus", - "use", - "metal", - "ions", - "scaffolds", - "crystallography", - "pb", - "peptide", - "time", - "designed", - "cd", - "hg", - "questions", - "provide", - "parallel", - "crystal", - "determined", - "exist", - "ii", - "nonmetalated", - "show", - "decades", - "basis", - "realized", - "position", - "bind", - "structure", - "establish", + "metallopeptides", + "leucines", + "defined", + "hydrophobic", + "structural", "repeat", - "held", - "zn", - "conformer", - "metallobiochemistry", - "however", - "conformations", - "spectroscopic", - "interfaces", - "general", - "coiled", - "resultant", + "show", + "cs", + "clarify", + "single", + "side", + "differences", + "heavy", + "cd", + "pb", + "insight", + "protein", "partially", - "differential", - "proteins", - "de", - "metalloregulatory", - "yielding", - "organization", - "influence", - "metallochaperones", - "used", - "yet", - "3", - "preorganized", - "dreams", - "forming", - "structures", - "ultimately", - "alternate", "pockets", - "coils", - "versus", - "corresponding", + "metallochaperones", + "binding", + "changes", "essential", - "assembly", - "suitable", - "either", - "cysteines", - "coil", - "cs", - "first", - "rules", + "site", + "novo", + "yielding", + "metallobiochemistry", + "general", + "csl19c", "systems", - "glu", - "quality", - "data", - "replaced", - "respectively", - "defined", - "generate", - "changes", - "may", - "19", - "9", - "iii", - "g", - "behavior", + "forms", "apo", - "metalated", - "observed", - "metals", - "characterization", "promise", + "two", + "variety", + "crystal", + "establish", + "hg", + "chains", + "dreams", + "questions", + "g", + "rules", + "zn", + "corresponding", "using", - "present", - "hydrophobic", + "resultant", + "either", "elaborate", - "ser", - "heavy", - "coordinate", - "packing", - "structural", - "metallopeptides", - "inherent", + "however", + "metal", + "organization", + "respectively", + "metals", + "interior", + "influence", + "thus", + "residues", + "bind", + "basis", + "bound", "sites", + "proteins", + "packing", + "characterization", + "ions", + "19", + "use", + "may", + "iii", + "coils", + "peptide", + "forming", + "heptad", + "lack", + "speculate", + "spectroscopic", + "behavior", + "used", "past", - "chains", + "yet", + "assembly", + "nonmetalated", "cysteine", - "one", - "fundamental", - "clarify", - "lack", "complexation", - "novo", - "single", - "leucines", - "csl19c", - "speculate", - "understand", - "peptides", - "insight", - "residues", - "two", - "cys", - "examples", - "binding", - "protein", - "bound", + "9", + "decades", + "glu", + "realized", + "metalated", + "time", + "parallel", "resolutions", - "variety", - "interior", - "differences", "types", - "understanding", "csl9c", - "side", - "site", - "forms", + "peptides", "crystals", - "whereas" + "present", + "whereas", + "versus", + "exist", + "fundamental", + "designed", + "interfaces", + "one", + "observed", + "structures", + "de", + "constructs", + "ser", + "suitable", + "understand", + "first", + "3", + "differential", + "conformer", + "structure", + "scaffolds", + "replaced", + "alternate", + "determined", + "provide", + "herein", + "coordinate", + "crystallography", + "understanding", + "cysteines", + "examples", + "cys", + "coiled", + "coil", + "ultimately", + "preorganized", + "conformations", + "position", + "data", + "reports", + "quality", + "held", + "inherent", + "generate", + "metalloregulatory", + "ii" ], "release_date":"2010-09-15", "publication":"\"Structural comparisons of apo- and metalated three-stranded coiled coils clarify metal binding determinants in thiolate containing designed peptides\", J.Am.Chem.Soc., 132, 13240-13250", @@ -42764,14 +42798,14 @@ "sim":0.961499989, "partner":"3h5g" }, - { - "sim":0.9958000183, - "partner":"2x6p" - }, { "sim":0.9919999838, "partner":"5uxt" }, + { + "sim":0.9958000183, + "partner":"2x6p" + }, { "sim":0.9911999702, "partner":"6osd" @@ -42793,16 +42827,16 @@ "partner":"6v5j" }, { - "sim":0.9911000133, - "partner":"6v50" + "sim":0.9542000294, + "partner":"5kb0" }, { "sim":0.9880999923, "partner":"6u47" }, { - "sim":0.9911999702, - "partner":"6v4y" + "sim":0.9911000133, + "partner":"6v50" }, { "sim":0.9911000133, @@ -42817,8 +42851,12 @@ "partner":"6v58" }, { - "sim":0.9521999955, - "partner":"6v57" + "sim":0.9911999702, + "partner":"6v4y" + }, + { + "sim":0.9628000259, + "partner":"1coi" }, { "sim":0.9524999857, @@ -42837,36 +42875,32 @@ "partner":"6q22" }, { - "sim":0.9534999728, - "partner":"6ov9" + "sim":0.9983000159, + "partner":"5vte" }, { - "sim":0.9628000259, - "partner":"1coi" + "sim":0.9574000239, + "partner":"1fmh" }, { - "sim":0.9559999704, - "partner":"6q5r" + "sim":0.9521999955, + "partner":"6v57" }, { - "sim":0.9983000159, - "partner":"5vte" + "sim":0.9534999728, + "partner":"6ov9" }, { "sim":0.9559999704, - "partner":"6q5s" + "partner":"6q5r" }, { - "sim":0.9574000239, - "partner":"1fmh" + "sim":0.9559999704, + "partner":"6q5s" }, { "sim":0.9542000294, "partner":"6q5q" - }, - { - "sim":0.9542000294, - "partner":"5kb0" } ], "struct_thr_sim_natural":[ @@ -42937,107 +42971,107 @@ ], "subtitle":"A non-biological atp binding protein with a single point mutation (d65v), that contributes to optimized folding and ligand binding, crystallized in the presence of 100 mm atp", "tags":[ - "non-biological protein", + "bent atp", "de novo protein", "alpha\/beta fold", - "bent atp" + "non-biological protein" ], "keywords":[ - "represents", - "period", + "turnovers", + "equimolar", + "methods", + "excess", "multiple", - "modes", - "challenge", - "scaffolds", - "crystallography", - "adp", + "presence", + "2009", + "three", + "new", + "residue", + "model", + "protein", + "six", "prolonged", - "time", + "linear", + "adp", + "binding", + "together", + "novo", + "demonstrate", "perform", - "methods", - "determined", - "complement", - "synthetic", - "bind", - "dx", - "unusual", - "equimolar", + "major", + "applications", + "substitution", + "emerges", + "binds", + "using", + "reaction", + "observation", + "creation", + "represents", + "distorted", + "selected", + "modes", + "transitional", "novel", - "catalysis", + "functions", + "address", + "bind", + "stability", + "tightly", + "tyr", + "bound", "proteins", - "asp", - "de", + "capable", "enzymes", - "linear", + "asp", + "found", + "future", + "et", + "al", + "slow", + "configuration", "crystallized", - "presence", - "used", + "65", "suggests", + "used", + "simmons", + "biology", "simple", - "binds", + "atp", + "addition", + "complement", + "evident", + "conditions", "ability", + "time", + "substituted", + "present", + "describe", + "unusual", + "cofactor", + "val", + "catalysis", "structures", - "future", - "three", - "65", - "tightly", - "tyr", - "biology", - "emerges", + "de", "previously", - "stability", "crystallization", - "biol", - "2009", - "al", "predefined", - "substitution", - "conditions", - "generate", + "synthetic", + "scaffolds", + "determined", + "43", + "crystallography", + "state", "4", - "address", - "functions", - "configuration", - "et", - "six", - "model", - "using", - "applications", - "present", - "describe", - "observation", - "selected", - "distorted", - "transitional", - "demonstrate", + "phe", + "biol", "despite", - "substituted", - "simmons", - "novo", - "cofactor", - "val", - "together", - "evident", - "reaction", - "capable", - "found", - "turnovers", - "atp", - "state", - "addition", - "creation", + "dx", + "period", + "challenge", "acs", - "protein", - "bound", - "residue", - "phe", - "43", - "excess", - "chem", - "major", - "binding", - "slow", - "new" + "generate", + "chem" ], "release_date":"2010-09-22", "publication":"\"Three-dimensional structures reveal multiple ADP\/ATP binding modes for a synthetic class of artificial proteins\", Biochemistry, 49, 8689-8699", @@ -43223,107 +43257,107 @@ ], "subtitle":"A non-biological atp binding protein with a single point mutation (d65v), that contributes to optimized folding and ligand binding", "tags":[ - "non-biological protein", + "bent atp", "de novo protein", "alpha\/beta fold", - "bent atp" + "non-biological protein" ], "keywords":[ - "represents", - "period", + "turnovers", + "equimolar", + "methods", + "excess", "multiple", - "modes", - "challenge", - "scaffolds", - "crystallography", - "adp", + "presence", + "2009", + "three", + "new", + "residue", + "model", + "protein", + "six", "prolonged", - "time", + "linear", + "adp", + "binding", + "together", + "novo", + "demonstrate", "perform", - "methods", - "determined", - "complement", - "synthetic", - "bind", - "dx", - "unusual", - "equimolar", + "major", + "applications", + "substitution", + "emerges", + "binds", + "using", + "reaction", + "observation", + "creation", + "represents", + "distorted", + "selected", + "modes", + "transitional", "novel", - "catalysis", + "functions", + "address", + "bind", + "stability", + "tightly", + "tyr", + "bound", "proteins", - "asp", - "de", + "capable", "enzymes", - "linear", + "asp", + "found", + "future", + "et", + "al", + "slow", + "configuration", "crystallized", - "presence", - "used", + "65", "suggests", + "used", + "simmons", + "biology", "simple", - "binds", + "atp", + "addition", + "complement", + "evident", + "conditions", "ability", + "time", + "substituted", + "present", + "describe", + "unusual", + "cofactor", + "val", + "catalysis", "structures", - "future", - "three", - "65", - "tightly", - "tyr", - "biology", - "emerges", + "de", "previously", - "stability", "crystallization", - "biol", - "2009", - "al", "predefined", - "substitution", - "conditions", - "generate", + "synthetic", + "scaffolds", + "determined", + "43", + "crystallography", + "state", "4", - "address", - "functions", - "configuration", - "et", - "six", - "model", - "using", - "applications", - "present", - "describe", - "observation", - "selected", - "distorted", - "transitional", - "demonstrate", + "phe", + "biol", "despite", - "substituted", - "simmons", - "novo", - "cofactor", - "val", - "together", - "evident", - "reaction", - "capable", - "found", - "turnovers", - "atp", - "state", - "addition", - "creation", + "dx", + "period", + "challenge", "acs", - "protein", - "bound", - "residue", - "phe", - "43", - "excess", - "chem", - "major", - "binding", - "slow", - "new" + "generate", + "chem" ], "release_date":"2010-09-22", "publication":"\"Three-dimensional structures reveal multiple ADP\/ATP binding modes for a synthetic class of artificial proteins\", Biochemistry, 49, 8689-8699", @@ -43509,107 +43543,107 @@ ], "subtitle":"Crystal structure of a non-biological atp binding protein with a tyr-phe mutation within the ligand binding domain", "tags":[ - "non-biological protein", + "bent atp", "de novo protein", "alpha\/beta fold", - "bent atp" + "non-biological protein" ], "keywords":[ - "represents", - "period", + "turnovers", + "equimolar", + "methods", + "excess", "multiple", - "modes", - "challenge", - "scaffolds", - "crystallography", - "adp", + "presence", + "2009", + "three", + "new", + "residue", + "model", + "protein", + "six", "prolonged", - "time", + "linear", + "adp", + "binding", + "together", + "novo", + "demonstrate", "perform", - "methods", - "determined", - "complement", - "synthetic", - "bind", - "dx", - "unusual", - "equimolar", + "major", + "applications", + "substitution", + "emerges", + "binds", + "using", + "reaction", + "observation", + "creation", + "represents", + "distorted", + "selected", + "modes", + "transitional", "novel", - "catalysis", + "functions", + "address", + "bind", + "stability", + "tightly", + "tyr", + "bound", "proteins", - "asp", - "de", + "capable", "enzymes", - "linear", + "asp", + "found", + "future", + "et", + "al", + "slow", + "configuration", "crystallized", - "presence", - "used", + "65", "suggests", + "used", + "simmons", + "biology", "simple", - "binds", + "atp", + "addition", + "complement", + "evident", + "conditions", "ability", + "time", + "substituted", + "present", + "describe", + "unusual", + "cofactor", + "val", + "catalysis", "structures", - "future", - "three", - "65", - "tightly", - "tyr", - "biology", - "emerges", + "de", "previously", - "stability", "crystallization", - "biol", - "2009", - "al", "predefined", - "substitution", - "conditions", - "generate", + "synthetic", + "scaffolds", + "determined", + "43", + "crystallography", + "state", "4", - "address", - "functions", - "configuration", - "et", - "six", - "model", - "using", - "applications", - "present", - "describe", - "observation", - "selected", - "distorted", - "transitional", - "demonstrate", + "phe", + "biol", "despite", - "substituted", - "simmons", - "novo", - "cofactor", - "val", - "together", - "evident", - "reaction", - "capable", - "found", - "turnovers", - "atp", - "state", - "addition", - "creation", + "dx", + "period", + "challenge", "acs", - "protein", - "bound", - "residue", - "phe", - "43", - "excess", - "chem", - "major", - "binding", - "slow", - "new" + "generate", + "chem" ], "release_date":"2010-09-22", "publication":"\"Three-dimensional structures reveal multiple ADP\/ATP binding modes for a synthetic class of artificial proteins\", Biochemistry, 49, 8689-8699", @@ -43654,11 +43688,11 @@ }, { "sim":181.0, - "partner":"3lt9" + "partner":"3lt8" }, { "sim":181.0, - "partner":"3lt8" + "partner":"3lt9" }, { "sim":175.0, @@ -43795,107 +43829,107 @@ ], "subtitle":"X-ray structure of a non-biological atp binding protein determined in the presence of 10 mm atp at 2.6 a after 3 weeks of incubation", "tags":[ - "non-biological protein", + "bent atp", "de novo protein", "alpha\/beta fold", - "bent atp" + "non-biological protein" ], "keywords":[ - "represents", - "period", + "turnovers", + "equimolar", + "methods", + "excess", "multiple", - "modes", - "challenge", - "scaffolds", - "crystallography", - "adp", + "presence", + "2009", + "three", + "new", + "residue", + "model", + "protein", + "six", "prolonged", - "time", + "linear", + "adp", + "binding", + "together", + "novo", + "demonstrate", "perform", - "methods", - "determined", - "complement", - "synthetic", - "bind", - "dx", - "unusual", - "equimolar", + "major", + "applications", + "substitution", + "emerges", + "binds", + "using", + "reaction", + "observation", + "creation", + "represents", + "distorted", + "selected", + "modes", + "transitional", "novel", - "catalysis", + "functions", + "address", + "bind", + "stability", + "tightly", + "tyr", + "bound", "proteins", - "asp", - "de", + "capable", "enzymes", - "linear", + "asp", + "found", + "future", + "et", + "al", + "slow", + "configuration", "crystallized", - "presence", - "used", + "65", "suggests", + "used", + "simmons", + "biology", "simple", - "binds", + "atp", + "addition", + "complement", + "evident", + "conditions", "ability", + "time", + "substituted", + "present", + "describe", + "unusual", + "cofactor", + "val", + "catalysis", "structures", - "future", - "three", - "65", - "tightly", - "tyr", - "biology", - "emerges", + "de", "previously", - "stability", "crystallization", - "biol", - "2009", - "al", "predefined", - "substitution", - "conditions", - "generate", + "synthetic", + "scaffolds", + "determined", + "43", + "crystallography", + "state", "4", - "address", - "functions", - "configuration", - "et", - "six", - "model", - "using", - "applications", - "present", - "describe", - "observation", - "selected", - "distorted", - "transitional", - "demonstrate", + "phe", + "biol", "despite", - "substituted", - "simmons", - "novo", - "cofactor", - "val", - "together", - "evident", - "reaction", - "capable", - "found", - "turnovers", - "atp", - "state", - "addition", - "creation", + "dx", + "period", + "challenge", "acs", - "protein", - "bound", - "residue", - "phe", - "43", - "excess", - "chem", - "major", - "binding", - "slow", - "new" + "generate", + "chem" ], "release_date":"2010-09-22", "publication":"\"Three-dimensional structures reveal multiple ADP\/ATP binding modes for a synthetic class of artificial proteins\", Biochemistry, 49, 8689-8699", @@ -43940,11 +43974,11 @@ }, { "sim":183.0, - "partner":"3lt9" + "partner":"3lt8" }, { "sim":183.0, - "partner":"3lt8" + "partner":"3lt9" }, { "sim":176.0, @@ -44081,107 +44115,107 @@ ], "subtitle":"X-ray structure of a non-biological atp binding protein determined in the presence of 10 mm atp at 2.0 a by multi-wavelength anomalous dispersion", "tags":[ - "non-biological protein", + "bent atp", "de novo protein", "alpha\/beta fold", - "bent atp" + "non-biological protein" ], "keywords":[ - "represents", - "period", + "turnovers", + "equimolar", + "methods", + "excess", "multiple", - "modes", - "challenge", - "scaffolds", - "crystallography", - "adp", + "presence", + "2009", + "three", + "new", + "residue", + "model", + "protein", + "six", "prolonged", - "time", + "linear", + "adp", + "binding", + "together", + "novo", + "demonstrate", "perform", - "methods", - "determined", - "complement", - "synthetic", - "bind", - "dx", - "unusual", - "equimolar", + "major", + "applications", + "substitution", + "emerges", + "binds", + "using", + "reaction", + "observation", + "creation", + "represents", + "distorted", + "selected", + "modes", + "transitional", "novel", - "catalysis", + "functions", + "address", + "bind", + "stability", + "tightly", + "tyr", + "bound", "proteins", - "asp", - "de", + "capable", "enzymes", - "linear", + "asp", + "found", + "future", + "et", + "al", + "slow", + "configuration", "crystallized", - "presence", - "used", + "65", "suggests", + "used", + "simmons", + "biology", "simple", - "binds", + "atp", + "addition", + "complement", + "evident", + "conditions", "ability", + "time", + "substituted", + "present", + "describe", + "unusual", + "cofactor", + "val", + "catalysis", "structures", - "future", - "three", - "65", - "tightly", - "tyr", - "biology", - "emerges", + "de", "previously", - "stability", "crystallization", - "biol", - "2009", - "al", "predefined", - "substitution", - "conditions", - "generate", + "synthetic", + "scaffolds", + "determined", + "43", + "crystallography", + "state", "4", - "address", - "functions", - "configuration", - "et", - "six", - "model", - "using", - "applications", - "present", - "describe", - "observation", - "selected", - "distorted", - "transitional", - "demonstrate", + "phe", + "biol", "despite", - "substituted", - "simmons", - "novo", - "cofactor", - "val", - "together", - "evident", - "reaction", - "capable", - "found", - "turnovers", - "atp", - "state", - "addition", - "creation", + "dx", + "period", + "challenge", "acs", - "protein", - "bound", - "residue", - "phe", - "43", - "excess", - "chem", - "major", - "binding", - "slow", - "new" + "generate", + "chem" ], "release_date":"2010-09-22", "publication":"\"Three-dimensional structures reveal multiple ADP\/ATP binding modes for a synthetic class of artificial proteins\", Biochemistry, 49, 8689-8699", @@ -44226,11 +44260,11 @@ }, { "sim":183.0, - "partner":"3lt9" + "partner":"3lt8" }, { "sim":183.0, - "partner":"3lt8" + "partner":"3lt9" }, { "sim":176.0, @@ -44367,107 +44401,107 @@ ], "subtitle":"X-ray structure of a non-biological atp binding protein determined at 2.8 a by multi-wavelength anomalous dispersion", "tags":[ - "non-biological protein", + "bent atp", "de novo protein", "alpha\/beta fold", - "bent atp" + "non-biological protein" ], "keywords":[ - "represents", - "period", + "turnovers", + "equimolar", + "methods", + "excess", "multiple", - "modes", - "challenge", - "scaffolds", - "crystallography", - "adp", + "presence", + "2009", + "three", + "new", + "residue", + "model", + "protein", + "six", "prolonged", - "time", + "linear", + "adp", + "binding", + "together", + "novo", + "demonstrate", "perform", - "methods", - "determined", - "complement", - "synthetic", - "bind", - "dx", - "unusual", - "equimolar", + "major", + "applications", + "substitution", + "emerges", + "binds", + "using", + "reaction", + "observation", + "creation", + "represents", + "distorted", + "selected", + "modes", + "transitional", "novel", - "catalysis", + "functions", + "address", + "bind", + "stability", + "tightly", + "tyr", + "bound", "proteins", - "asp", - "de", + "capable", "enzymes", - "linear", + "asp", + "found", + "future", + "et", + "al", + "slow", + "configuration", "crystallized", - "presence", - "used", + "65", "suggests", + "used", + "simmons", + "biology", "simple", - "binds", + "atp", + "addition", + "complement", + "evident", + "conditions", "ability", + "time", + "substituted", + "present", + "describe", + "unusual", + "cofactor", + "val", + "catalysis", "structures", - "future", - "three", - "65", - "tightly", - "tyr", - "biology", - "emerges", + "de", "previously", - "stability", "crystallization", - "biol", - "2009", - "al", "predefined", - "substitution", - "conditions", - "generate", + "synthetic", + "scaffolds", + "determined", + "43", + "crystallography", + "state", "4", - "address", - "functions", - "configuration", - "et", - "six", - "model", - "using", - "applications", - "present", - "describe", - "observation", - "selected", - "distorted", - "transitional", - "demonstrate", + "phe", + "biol", "despite", - "substituted", - "simmons", - "novo", - "cofactor", - "val", - "together", - "evident", - "reaction", - "capable", - "found", - "turnovers", - "atp", - "state", - "addition", - "creation", + "dx", + "period", + "challenge", "acs", - "protein", - "bound", - "residue", - "phe", - "43", - "excess", - "chem", - "major", - "binding", - "slow", - "new" + "generate", + "chem" ], "release_date":"2010-09-22", "publication":"\"Three-dimensional structures reveal multiple ADP\/ATP binding modes for a synthetic class of artificial proteins\", Biochemistry, 49, 8689-8699", @@ -44512,11 +44546,11 @@ }, { "sim":183.0, - "partner":"3lt9" + "partner":"3lt8" }, { "sim":183.0, - "partner":"3lt8" + "partner":"3lt9" }, { "sim":176.0, @@ -44665,135 +44699,135 @@ ], "subtitle":"Structure of a new family of artificial alpha helicoidal repeat proteins (alpha-rep) based on thermostable heat-like repeats", "tags":[ - "heat-like repeat", "protein binding", + "heat-like repeat", "protein engineering" ], "keywords":[ - "analysis", - "evolution", - "results", - "located", - "long", - "studies", - "architecture", - "crevice", - "scattering", - "low", - "expressed", + "made", + "picked", + "repeats", + "genes", + "dimers", + "defined", + "molecular", + "repeat", + "number", + "thermostable", + "organized", + "well", + "randomized", + "side", "randomly", - "variable", + "results", + "scanning", + "new", + "make", + "assembled", + "numbers", + "calorimetry", + "protein", + "mass", + "positions", + "dimerization", + "binding", + "showed", + "site", + "apo", + "circular", + "expected", "purified", - "dimeric", + "heat", + "attractive", + "stable", + "helices", + "chains", + "using", + "methodology", + "either", "flexibility", - "irregular", - "based", - "enriched", - "sequences", - "versatile", - "assembled", - "validate", - "structure", - "repeat", - "alpha", - "fortuitous", - "gel", - "combinations", "later", - "thermostable", - "increases", - "aromatic", - "topology", - "differential", - "proteins", - "models", - "solved", - "probably", - "although", "characterized", - "hypervariable", - "crystallized", "organization", - "number", - "interface", - "used", - "highly", - "site", + "soluble", + "hypervariable", + "dimer", + "identified", + "increases", + "residues", "coding", - "made", + "although", + "library", + "useful", "folded", - "positions", - "pairs", - "showed", - "circular", - "appropriate", - "either", - "numbers", - "heat", - "form", - "cooperatively", - "consensus", - "properties", "stability", + "proteins", + "low", + "scattering", + "consensus", + "modular", + "architecture", + "fortuitous", + "\u03b1rep", + "scaffold", + "highly", + "interface", + "evolution", + "long", + "pairs", + "variable", + "surface", + "design", + "topology", + "crystallized", + "used", + "named", + "combinations", + "different", "monomers", - "molecular", - "expected", - "randomized", - "directly", - "defined", + "properties", + "variant", + "gel", + "experiments", + "appropriate", + "revealing", + "validate", + "alpha", + "filtration", + "sequence", + "solved", "common", - "scanning", - "detailed", - "70", - "artificial", - "useful", - "dimer", - "apo", - "calorimetry", - "amplification", - "design", - "soluble", - "using", + "versatile", "present", - "surface", - "sequence", - "repeats", - "genes", + "enriched", + "prove", "could", - "dimerization", - "variant", - "library", - "make", - "chains", - "helices", - "revealing", - "stable", - "attractive", - "experiments", - "named", - "directed", - "modular", - "well", - "different", - "residues", - "identified", - "dimers", - "scaffold", - "picked", + "directly", + "form", "partners", - "prove", - "filtration", - "protein", + "analysis", + "directed", + "models", + "sequences", + "cooperatively", + "aromatic", + "expressed", + "amplification", + "detailed", + "based", + "70", + "differential", + "structure", + "irregular", + "biophysical", + "crevice", "regular", - "\u03b1rep", - "methodology", - "mass", - "side", + "artificial", + "located", "dichroism", - "organized", - "binding", - "biophysical", - "new" + "probably", + "studies", + "dimeric" ], "release_date":"2010-10-13", "publication":"\"Design, production and molecular structure of a new family of artificial alpha-helicoidal repeat proteins ( alpha Rep) based on thermostable HEAT-like repeats\", J.Mol.Biol., 404, 307-327", @@ -44834,11 +44868,11 @@ }, { "sim":293.0, - "partner":"4zv6" + "partner":"6bzx" }, { "sim":293.0, - "partner":"6bzx" + "partner":"4zv6" }, { "sim":284.0, @@ -44952,135 +44986,135 @@ ], "subtitle":"Structure of a new family of artificial alpha helicoidal repeat proteins (alpha-rep) based on thermostable heat-like repeats", "tags":[ - "heat-like repeat", "protein binding", + "heat-like repeat", "protein engineering" ], "keywords":[ - "analysis", - "evolution", - "results", - "located", - "long", - "studies", - "architecture", - "crevice", - "scattering", - "low", - "expressed", + "made", + "picked", + "repeats", + "genes", + "dimers", + "defined", + "molecular", + "repeat", + "number", + "thermostable", + "organized", + "well", + "randomized", + "side", "randomly", - "variable", + "results", + "scanning", + "new", + "make", + "assembled", + "numbers", + "calorimetry", + "protein", + "mass", + "positions", + "dimerization", + "binding", + "showed", + "site", + "apo", + "circular", + "expected", "purified", - "dimeric", + "heat", + "attractive", + "stable", + "helices", + "chains", + "using", + "methodology", + "either", "flexibility", - "irregular", - "based", - "enriched", - "sequences", - "versatile", - "assembled", - "validate", - "structure", - "repeat", - "alpha", - "fortuitous", - "gel", - "combinations", "later", - "thermostable", - "increases", - "aromatic", - "topology", - "differential", - "proteins", - "models", - "solved", - "probably", - "although", "characterized", - "hypervariable", - "crystallized", "organization", - "number", - "interface", - "used", - "highly", - "site", + "soluble", + "hypervariable", + "dimer", + "identified", + "increases", + "residues", "coding", - "made", + "although", + "library", + "useful", "folded", - "positions", + "stability", + "proteins", + "low", + "scattering", + "consensus", + "modular", + "architecture", + "fortuitous", + "\u03b1rep", + "scaffold", + "highly", + "interface", + "evolution", + "long", "pairs", - "showed", - "circular", + "variable", + "surface", + "design", + "topology", + "crystallized", + "used", + "named", + "combinations", + "different", + "monomers", + "properties", + "variant", + "gel", + "experiments", "appropriate", - "either", - "numbers", - "heat", + "revealing", + "validate", + "alpha", + "filtration", + "sequence", + "solved", + "common", + "versatile", + "present", + "enriched", + "prove", + "could", + "directly", "form", + "partners", + "analysis", + "directed", + "models", + "sequences", "cooperatively", - "consensus", - "properties", - "stability", - "monomers", - "molecular", - "expected", - "randomized", - "directly", - "defined", - "common", - "scanning", + "aromatic", + "expressed", + "amplification", "detailed", + "based", "70", - "artificial", - "useful", - "dimer", - "apo", - "calorimetry", - "amplification", - "design", - "soluble", - "using", - "present", - "surface", - "sequence", - "repeats", - "genes", - "could", - "dimerization", - "variant", - "library", - "make", - "chains", - "helices", - "revealing", - "stable", - "attractive", - "experiments", - "named", - "directed", - "modular", - "well", - "different", - "residues", - "identified", - "dimers", - "scaffold", - "picked", - "partners", - "prove", - "filtration", - "protein", + "differential", + "structure", + "irregular", + "biophysical", + "crevice", "regular", - "\u03b1rep", - "methodology", - "mass", - "side", + "artificial", + "located", "dichroism", - "organized", - "binding", - "biophysical", - "new" + "probably", + "studies", + "dimeric" ], "release_date":"2010-10-13", "publication":"\"Design, production and molecular structure of a new family of artificial alpha-helicoidal repeat proteins ( alpha Rep) based on thermostable HEAT-like repeats\", J.Mol.Biol., 404, 307-327", @@ -45125,11 +45159,11 @@ }, { "sim":279.0, - "partner":"4zv6" + "partner":"6bzx" }, { "sim":279.0, - "partner":"6bzx" + "partner":"4zv6" }, { "sim":196.0, @@ -45237,68 +45271,68 @@ "acylimine-containing blue and red chromophores" ], "keywords":[ - "da", + "c", + "conformation", "analysis", - "data", + "mtagbfp", + "beta", + "functionality", + "indicate", + "formed", "chain", - "intermediate", - "conjugated", - "reveals", - "blue", - "acetamide", - "via", - "chemical", - "similar", - "whereas", + "derivative", + "structures", + "suggests", "single", - "leu63", - "peptide", + "oxidized", + "conjugated", "presence", - "tandem", - "trans", - "methylidene", - "suggests", - "crystal", - "system", + "tyr64", + "side", + "via", + "fluorescent", "determined", - "mtagbfp", + "leu63", + "new", + "da", "red", - "crystallographic", + "loss", "model", - "functionality", - "type", - "mechanism", - "structures", + "maturation", "protein", + "propose", + "mass", + "20", + "acetamide", + "type", + "alpha", + "intermediate", + "anionic", + "tagrfp", + "tandem", "upon", - "conformation", + "system", + "reveals", + "methylidene", + "trans", + "chromophore", "bond", - "spectrometry", - "refined", - "propose", - "loss", - "c", - "derivative", "coplanar", - "chromophore", - "alpha", - "maturation", - "beta", - "tyr64", - "indicate", - "oxidized", + "data", "chromophores", - "mass", + "crystal", + "whereas", + "chemical", + "blue", + "mechanism", + "spectrometry", + "crystallographic", "spectrum", - "20", - "tagrfp", - "side", - "consistent", "indicates", - "anionic", - "formed", - "new", - "fluorescent" + "refined", + "similar", + "peptide", + "consistent" ], "release_date":"2010-05-12", "publication":"\"Structural characterization of acylimine-containing blue and red chromophores in mTagBFP and TagRFP fluorescent proteins\", Chem.Biol., 17, 333-341", @@ -45351,10 +45385,6 @@ } ], "seq_thr_sim_natural":[ - { - "sim":479.0, - "partner":"3bxc" - }, { "sim":479.0, "partner":"3bx9" @@ -45368,13 +45398,17 @@ "partner":"3bxb" }, { - "sim":478.0, - "partner":"3h1o" + "sim":479.0, + "partner":"3bxc" }, { "sim":478.0, "partner":"3h1r" }, + { + "sim":478.0, + "partner":"3h1o" + }, { "sim":477.0, "partner":"3ip2" @@ -45477,11 +45511,11 @@ }, { "sim":265.0, - "partner":"1ggx" + "partner":"1zgo" }, { "sim":265.0, - "partner":"1zgo" + "partner":"1ggx" }, { "sim":264.0, @@ -45537,11 +45571,11 @@ }, { "sim":239.0, - "partner":"2z6x" + "partner":"2iov" }, { "sim":239.0, - "partner":"2iov" + "partner":"2z6x" }, { "sim":239.0, @@ -45567,6 +45601,10 @@ "sim":238.0, "partner":"2gx2" }, + { + "sim":231.0, + "partner":"8ul1" + }, { "sim":231.0, "partner":"8ul2" @@ -45583,10 +45621,6 @@ "sim":231.0, "partner":"8ul5" }, - { - "sim":231.0, - "partner":"8ul1" - }, { "sim":231.0, "partner":"1zux" @@ -45595,10 +45629,6 @@ "sim":230.0, "partner":"1xss" }, - { - "sim":229.0, - "partner":"2a53" - }, { "sim":229.0, "partner":"2a54" @@ -45611,6 +45641,10 @@ "sim":229.0, "partner":"1xmz" }, + { + "sim":229.0, + "partner":"2a53" + }, { "sim":229.0, "partner":"2hqk" @@ -45633,11 +45667,11 @@ }, { "sim":226.0, - "partner":"2vvi" + "partner":"2vvh" }, { "sim":226.0, - "partner":"2vvh" + "partner":"2vvi" }, { "sim":226.0, @@ -45799,18 +45833,6 @@ "sim":84.0, "partner":"1huy" }, - { - "sim":84.0, - "partner":"3dqc" - }, - { - "sim":84.0, - "partner":"3dqd" - }, - { - "sim":84.0, - "partner":"3dqe" - }, { "sim":84.0, "partner":"3dqf" @@ -45904,13 +45926,25 @@ "partner":"3dqa" }, { - "sim":83.0, - "partner":"1q4e" + "sim":84.0, + "partner":"3dqc" + }, + { + "sim":84.0, + "partner":"3dqd" + }, + { + "sim":84.0, + "partner":"3dqe" }, { "sim":83.0, "partner":"1q73" }, + { + "sim":83.0, + "partner":"1q4e" + }, { "sim":83.0, "partner":"1kp5" @@ -45925,7 +45959,11 @@ }, { "sim":82.0, - "partner":"2dui" + "partner":"1w7s" + }, + { + "sim":82.0, + "partner":"8rlb" }, { "sim":82.0, @@ -45933,7 +45971,7 @@ }, { "sim":82.0, - "partner":"1w7s" + "partner":"8rlc" }, { "sim":82.0, @@ -45945,16 +45983,28 @@ }, { "sim":82.0, - "partner":"1b9c" + "partner":"1w7u" }, { "sim":82.0, - "partner":"1w7u" + "partner":"8rle" + }, + { + "sim":82.0, + "partner":"1b9c" }, { "sim":82.0, "partner":"1hcj" }, + { + "sim":82.0, + "partner":"2dui" + }, + { + "sim":82.0, + "partner":"8rl9" + }, { "sim":82.0, "partner":"2hgy" @@ -45980,32 +46030,32 @@ "partner":"2b3p" }, { - "sim":81.0, - "partner":"2qz0" + "sim":82.0, + "partner":"8xal" }, { "sim":81.0, - "partner":"1q4c" + "partner":"2qz0" }, { "sim":81.0, - "partner":"2hqz" + "partner":"2qle" }, { "sim":81.0, - "partner":"2hrs" + "partner":"8jl2" }, { "sim":81.0, - "partner":"1q4d" + "partner":"8jkc" }, { "sim":81.0, - "partner":"1rmo" + "partner":"8jkg" }, { "sim":81.0, - "partner":"2qle" + "partner":"2ah8" }, { "sim":81.0, @@ -46019,29 +46069,21 @@ "sim":81.0, "partner":"1jby" }, - { - "sim":81.0, - "partner":"1jbz" - }, - { - "sim":81.0, - "partner":"2ah8" - }, { "sim":81.0, "partner":"2yfp" }, { "sim":81.0, - "partner":"8jl2" + "partner":"1jbz" }, { "sim":81.0, - "partner":"8jkc" + "partner":"2aha" }, { "sim":81.0, - "partner":"8jkg" + "partner":"8jl5" }, { "sim":81.0, @@ -46049,7 +46091,7 @@ }, { "sim":81.0, - "partner":"2aha" + "partner":"8jl6" }, { "sim":81.0, @@ -46059,18 +46101,10 @@ "sim":81.0, "partner":"1rm9" }, - { - "sim":81.0, - "partner":"8jl5" - }, { "sim":81.0, "partner":"3k1k" }, - { - "sim":81.0, - "partner":"8jl6" - }, { "sim":81.0, "partner":"8jls" @@ -46093,19 +46127,23 @@ }, { "sim":81.0, - "partner":"1bfp" + "partner":"8jll" }, { "sim":81.0, - "partner":"1gfl" + "partner":"8jlm" }, { "sim":81.0, - "partner":"8jll" + "partner":"2due" }, { "sim":81.0, - "partner":"2due" + "partner":"1bfp" + }, + { + "sim":81.0, + "partner":"1gfl" }, { "sim":81.0, @@ -46125,15 +46163,31 @@ }, { "sim":81.0, - "partner":"8jlm" + "partner":"1q4b" }, { "sim":81.0, - "partner":"1q4b" + "partner":"2duh" }, { "sim":81.0, - "partner":"2duh" + "partner":"1q4c" + }, + { + "sim":81.0, + "partner":"2hqz" + }, + { + "sim":81.0, + "partner":"2hrs" + }, + { + "sim":81.0, + "partner":"1q4d" + }, + { + "sim":81.0, + "partner":"1rmo" }, { "sim":81.0, @@ -46237,11 +46291,11 @@ }, { "sim":80.0, - "partner":"2q6p" + "partner":"2wur" }, { "sim":80.0, - "partner":"2wur" + "partner":"2q6p" }, { "sim":80.0, @@ -46317,11 +46371,11 @@ }, { "sim":79.0, - "partner":"1jc1" + "partner":"2okw" }, { "sim":79.0, - "partner":"2okw" + "partner":"1jc1" }, { "sim":79.0, @@ -46335,10 +46389,6 @@ "sim":79.0, "partner":"2hjo" }, - { - "sim":79.0, - "partner":"1kyp" - }, { "sim":79.0, "partner":"2fwq" @@ -46353,15 +46403,15 @@ }, { "sim":79.0, - "partner":"1emf" + "partner":"2hcg" }, { "sim":79.0, - "partner":"2hcg" + "partner":"2emd" }, { "sim":79.0, - "partner":"2emd" + "partner":"1emf" }, { "sim":79.0, @@ -46375,6 +46425,10 @@ "sim":79.0, "partner":"1yj2" }, + { + "sim":79.0, + "partner":"1kyp" + }, { "sim":79.0, "partner":"8iyz" @@ -46385,15 +46439,15 @@ }, { "sim":78.0, - "partner":"1rmp" + "partner":"1rrx" }, { "sim":78.0, - "partner":"1rrx" + "partner":"1rmm" }, { "sim":78.0, - "partner":"1rmm" + "partner":"1rmp" }, { "sim":78.0, @@ -46447,10 +46501,6 @@ "sim":76.0, "partner":"1oxf" }, - { - "sim":75.0, - "partner":"1qyo" - }, { "sim":75.0, "partner":"3lva" @@ -46463,6 +46513,10 @@ "sim":75.0, "partner":"3lvd" }, + { + "sim":75.0, + "partner":"1qyo" + }, { "sim":75.0, "partner":"1yhh" @@ -46481,11 +46535,11 @@ }, { "sim":68.0, - "partner":"2g6x" + "partner":"2g6y" }, { "sim":68.0, - "partner":"2g6y" + "partner":"2g6x" }, { "sim":65.0, @@ -46542,7 +46596,7 @@ }, "seq_max_sim_natural":{ "sim":479.0, - "partner":"3bxc" + "partner":"3bx9" }, "struct_max_sim_designed":{ "sim":0.9693999887, @@ -46608,73 +46662,73 @@ ], "subtitle":"Crystal structure of tagbfp fluorescent protein", "tags":[ - "de novo protein", "fluorescent proteins", + "de novo protein", "acylimine-containing blue and red chromophores" ], "keywords":[ - "da", + "c", + "conformation", "analysis", - "data", + "mtagbfp", + "beta", + "functionality", + "indicate", + "formed", "chain", - "intermediate", - "conjugated", - "reveals", - "blue", - "acetamide", - "via", - "chemical", - "similar", - "whereas", + "derivative", + "structures", + "suggests", "single", - "leu63", - "peptide", + "oxidized", + "conjugated", "presence", - "tandem", - "trans", - "methylidene", - "suggests", - "crystal", - "system", + "tyr64", + "side", + "via", + "fluorescent", "determined", - "mtagbfp", + "leu63", + "new", + "da", "red", - "crystallographic", + "loss", "model", - "functionality", - "type", - "mechanism", - "structures", + "maturation", "protein", + "propose", + "mass", + "20", + "acetamide", + "type", + "alpha", + "intermediate", + "anionic", + "tagrfp", + "tandem", "upon", - "conformation", + "system", + "reveals", + "methylidene", + "trans", + "chromophore", "bond", - "spectrometry", - "refined", - "propose", - "loss", - "c", - "derivative", "coplanar", - "chromophore", - "alpha", - "maturation", - "beta", - "tyr64", - "indicate", - "oxidized", + "data", "chromophores", - "mass", + "crystal", + "whereas", + "chemical", + "blue", + "mechanism", + "spectrometry", + "crystallographic", "spectrum", - "20", - "tagrfp", - "side", - "consistent", "indicates", - "anionic", - "formed", - "new", - "fluorescent" + "refined", + "similar", + "peptide", + "consistent" ], "release_date":"2010-05-26", "publication":"\"Structural characterization of acylimine-containing blue and red chromophores in mTagBFP and TagRFP fluorescent proteins\", Chem.Biol., 17, 333-341", @@ -46727,10 +46781,6 @@ } ], "seq_thr_sim_natural":[ - { - "sim":460.0, - "partner":"3bxc" - }, { "sim":460.0, "partner":"3bx9" @@ -46744,13 +46794,17 @@ "partner":"3bxb" }, { - "sim":456.0, - "partner":"3h1o" + "sim":460.0, + "partner":"3bxc" }, { "sim":456.0, "partner":"3h1r" }, + { + "sim":456.0, + "partner":"3h1o" + }, { "sim":455.0, "partner":"3ip2" @@ -46825,15 +46879,15 @@ }, { "sim":257.0, - "partner":"1g7k" + "partner":"3kcs" }, { "sim":257.0, - "partner":"3kcs" + "partner":"3kct" }, { "sim":257.0, - "partner":"3kct" + "partner":"1g7k" }, { "sim":256.0, @@ -46849,11 +46903,11 @@ }, { "sim":255.0, - "partner":"1ggx" + "partner":"1zgo" }, { "sim":255.0, - "partner":"1zgo" + "partner":"1ggx" }, { "sim":254.0, @@ -46915,6 +46969,10 @@ "sim":218.0, "partner":"2z6x" }, + { + "sim":217.0, + "partner":"8ul1" + }, { "sim":217.0, "partner":"8ul2" @@ -46931,10 +46989,6 @@ "sim":217.0, "partner":"8ul5" }, - { - "sim":217.0, - "partner":"8ul1" - }, { "sim":217.0, "partner":"2ie2" @@ -46963,10 +47017,6 @@ "sim":217.0, "partner":"2pox" }, - { - "sim":216.0, - "partner":"2a53" - }, { "sim":216.0, "partner":"2a54" @@ -46979,6 +47029,10 @@ "sim":216.0, "partner":"2a50" }, + { + "sim":216.0, + "partner":"2a53" + }, { "sim":216.0, "partner":"2hqk" @@ -47009,11 +47063,11 @@ }, { "sim":213.0, - "partner":"2vvi" + "partner":"2vvh" }, { "sim":213.0, - "partner":"2vvh" + "partner":"2vvi" }, { "sim":211.0, @@ -47101,11 +47155,11 @@ }, { "sim":162.0, - "partner":"2ojk" + "partner":"1xa9" }, { "sim":162.0, - "partner":"1xa9" + "partner":"2ojk" }, { "sim":160.0, @@ -47212,60 +47266,60 @@ "partner":"8iz0" }, { - "sim":72.0, - "partner":"1q4c" + "sim":73.0, + "partner":"8xal" }, { "sim":72.0, - "partner":"2dui" + "partner":"2qle" }, { "sim":72.0, - "partner":"2hqz" + "partner":"2ah8" }, { "sim":72.0, - "partner":"2hrs" + "partner":"1ema" }, { "sim":72.0, - "partner":"1q4d" + "partner":"1emb" }, { "sim":72.0, - "partner":"1q4e" + "partner":"1jby" }, { "sim":72.0, - "partner":"2qle" + "partner":"1w7s" }, { "sim":72.0, - "partner":"1ema" + "partner":"2yfp" }, { "sim":72.0, - "partner":"1emb" + "partner":"8rlb" }, { "sim":72.0, - "partner":"1jby" + "partner":"1jbz" }, { "sim":72.0, - "partner":"1jbz" + "partner":"2aha" }, { "sim":72.0, - "partner":"2ah8" + "partner":"8rlc" }, { "sim":72.0, - "partner":"1w7s" + "partner":"1q73" }, { "sim":72.0, - "partner":"2yfp" + "partner":"1w7t" }, { "sim":72.0, @@ -47273,27 +47327,35 @@ }, { "sim":72.0, - "partner":"2aha" + "partner":"1emg" }, { "sim":72.0, - "partner":"1q73" + "partner":"1w7u" }, { "sim":72.0, - "partner":"1w7t" + "partner":"8rle" }, { "sim":72.0, - "partner":"1emg" + "partner":"2due" }, { "sim":72.0, - "partner":"1w7u" + "partner":"1gfl" }, { "sim":72.0, - "partner":"1gfl" + "partner":"2duf" + }, + { + "sim":72.0, + "partner":"1q4a" + }, + { + "sim":72.0, + "partner":"2dug" }, { "sim":72.0, @@ -47301,43 +47363,43 @@ }, { "sim":72.0, - "partner":"2due" + "partner":"1q4b" }, { "sim":72.0, - "partner":"2duf" + "partner":"2duh" }, { "sim":72.0, - "partner":"1q4a" + "partner":"1q4c" }, { "sim":72.0, - "partner":"2dug" + "partner":"2dui" }, { "sim":72.0, - "partner":"1q4b" + "partner":"2hqz" }, { "sim":72.0, - "partner":"2duh" + "partner":"2hrs" }, { "sim":72.0, - "partner":"1myw" + "partner":"1q4d" }, { "sim":72.0, - "partner":"3dqc" + "partner":"8rl9" }, { "sim":72.0, - "partner":"3dqd" + "partner":"1q4e" }, { "sim":72.0, - "partner":"3dqe" + "partner":"1myw" }, { "sim":72.0, @@ -47431,6 +47493,18 @@ "sim":72.0, "partner":"3dqa" }, + { + "sim":72.0, + "partner":"3dqc" + }, + { + "sim":72.0, + "partner":"3dqd" + }, + { + "sim":72.0, + "partner":"3dqe" + }, { "sim":72.0, "partner":"8iyy" @@ -47479,10 +47553,6 @@ "sim":72.0, "partner":"8k4s" }, - { - "sim":71.0, - "partner":"2q6p" - }, { "sim":71.0, "partner":"8jl2" @@ -47525,11 +47595,11 @@ }, { "sim":71.0, - "partner":"1bfp" + "partner":"8jll" }, { "sim":71.0, - "partner":"8jll" + "partner":"8jlm" }, { "sim":71.0, @@ -47537,7 +47607,11 @@ }, { "sim":71.0, - "partner":"8jlm" + "partner":"1bfp" + }, + { + "sim":71.0, + "partner":"2q6p" }, { "sim":71.0, @@ -47593,11 +47667,11 @@ }, { "sim":70.0, - "partner":"1rmp" + "partner":"1rmm" }, { "sim":70.0, - "partner":"1rmm" + "partner":"1rmp" }, { "sim":70.0, @@ -47607,21 +47681,17 @@ "sim":70.0, "partner":"2qrf" }, - { - "sim":70.0, - "partner":"1rmo" - }, { "sim":70.0, "partner":"1jc0" }, { "sim":70.0, - "partner":"1jc1" + "partner":"2okw" }, { "sim":70.0, - "partner":"2okw" + "partner":"1jc1" }, { "sim":70.0, @@ -47639,6 +47709,10 @@ "sim":70.0, "partner":"2hjo" }, + { + "sim":70.0, + "partner":"1rmo" + }, { "sim":70.0, "partner":"1emc" @@ -47771,10 +47845,6 @@ "sim":68.0, "partner":"1s6z" }, - { - "sim":68.0, - "partner":"1kyp" - }, { "sim":68.0, "partner":"2fwq" @@ -47789,11 +47859,11 @@ }, { "sim":68.0, - "partner":"1emf" + "partner":"2emd" }, { "sim":68.0, - "partner":"2emd" + "partner":"1emf" }, { "sim":68.0, @@ -47807,6 +47877,10 @@ "sim":68.0, "partner":"2wsn" }, + { + "sim":68.0, + "partner":"1kyp" + }, { "sim":68.0, "partner":"3gex" @@ -47823,10 +47897,6 @@ "sim":67.0, "partner":"2hfc" }, - { - "sim":66.0, - "partner":"1qyo" - }, { "sim":66.0, "partner":"3lva" @@ -47841,12 +47911,16 @@ }, { "sim":66.0, - "partner":"2g6e" + "partner":"1qyo" }, { "sim":66.0, "partner":"1yhg" }, + { + "sim":66.0, + "partner":"2g6e" + }, { "sim":64.0, "partner":"1qyq" @@ -47861,11 +47935,11 @@ }, { "sim":61.0, - "partner":"2g6x" + "partner":"2g6y" }, { "sim":61.0, - "partner":"2g6y" + "partner":"2g6x" }, { "sim":57.0, @@ -47910,7 +47984,7 @@ }, "seq_max_sim_natural":{ "sim":460.0, - "partner":"3bxc" + "partner":"3bx9" }, "struct_max_sim_designed":{ "sim":0.9625999928, @@ -47976,92 +48050,92 @@ ], "subtitle":"54-membered ring macrocyclic beta-sheet peptide", "tags":[ - "unknown function", - "artificial beta sheet dimer" + "artificial beta sheet dimer", + "unknown function" ], "keywords":[ - "domain", - "many", - "ornithines", - "link", - "describes", - "ring", - "reverse", - "pattern", "trimer", - "related", - "tripeptide", - "peptide", - "place", - "designed", - "contains", - "modeling", - "arranged", - "8", - "conformation", + "dimers", + "molecular", "adopt", - "structure", - "turn", "defensin", - "acceptor", - "cyclic", - "fashion", + "resemble", + "pattern", + "macrocyclic", + "three", + "aligned", + "model", "resembles", - "array", - "remaining", + "presenting", + "dimerization", + "ribonuclease", + "tripeptide", + "acceptor", + "forms", + "two", + "triangular", + "related", + "takes", "induce", + "conformation", + "donor", + "formed", + "dimer", + "residues", + "place", + "ring", + "cyclic", "proteins", + "units", + "contains", + "interface", "hao", + "peptide", + "solid", + "help", + "provides", + "1a", + "domain", "edge", - "h", - "paper", - "interface", - "triangular", - "transcriptase", - "units", + "removed", + "groups", + "template", + "amino", "alternating", - "structures", "solution", - "three", - "macrocyclic", - "heptapeptide", - "molecular", - "strand", - "amino", + "describes", + "reverse", + "arranged", "reveals", - "ribonuclease", - "ornithine", - "presenting", - "template", - "acids", + "peptides", + "modeling", + "ornithines", + "crystallographic", + "remaining", + "designed", + "h", + "heptapeptide", + "array", + "one", + "many", "interleukin", - "aligned", + "observed", + "structures", + "link", + "structure", "closely", - "dimer", - "help", + "state", "unit", - "provides", - "observed", - "crystallographic", - "donor", - "model", - "repressor", - "resemble", - "dimerization", "mimics", - "one", - "groups", - "peptides", - "solid", - "1a", - "residues", - "takes", - "two", - "dimers", - "state", - "removed", - "formed", - "forms" + "fashion", + "transcriptase", + "strand", + "ornithine", + "acids", + "turn", + "repressor", + "8", + "paper" ], "release_date":"2010-09-15", "publication":"\"X-ray crystallographic structure of an artificial beta-sheet dimer\", J.Am.Chem.Soc., 132, 11622-11628", @@ -48155,72 +48229,72 @@ "de novo protein" ], "keywords":[ - "plausible", - "architectures", - "question", - "evolution", - "importance", - "despite", - "demonstrated", - "recapitulating", - "results", - "gene", - "utilized", - "pathway", - "architecture", - "hypothesized", - "via", - "unique", + "central", "threefold", - "route", - "strategy", - "intermediary", - "hypothesis", - "elements", - "experimental", + "exhibit", + "symmetry", + "responsible", "conserved", - "peptide", - "identify", - "fold", + "structural", + "fusion", "agree", - "emergence", - "successfully", - "effectively", - "processes", - "address", - "proposed", + "experimental", "simple", + "extant", + "question", "yet", - "capable", - "provide", + "previously", + "furthermore", + "processes", + "gene", + "via", + "properties", "specific", - "motif", - "symmetric", + "route", + "fold", + "elements", + "importance", + "results", + "provide", + "strategy", + "folding", "precisely", - "evolutionary", - "support", - "furthermore", - "generally", - "central", - "mechanism", - "previously", "model", - "deconstruction", "protein", - "symmetry", - "foldable", - "responsible", + "address", + "successfully", + "utilized", + "architectures", + "deconstruction", + "generally", + "majority", + "symmetric", + "capable", + "motif", + "plausible", + "identify", + "architecture", + "support", + "pathway", + "demonstrated", + "forms", "motifs", - "fusion", - "exhibit", - "extant", + "emergence", + "despite", + "effectively", + "evolution", "compelling", + "intermediary", + "unique", + "mechanism", + "foldable", + "recapitulating", + "proposed", + "hypothesis", "duplication", - "folding", - "structural", - "forms", - "majority", - "properties" + "hypothesized", + "peptide", + "evolutionary" ], "release_date":"2010-12-22", "publication":"\"Experimental support for the evolution of symmetric protein architecture from a simple peptide motif\", Proc.Natl.Acad.Sci.USA, 108, 126-130", @@ -48315,11 +48389,11 @@ }, { "sim":132.0, - "partner":"1jtc" + "partner":"3fjd" }, { "sim":132.0, - "partner":"3fjd" + "partner":"1jtc" }, { "sim":131.0, @@ -48369,18 +48443,6 @@ "sim":130.0, "partner":"1jt5" }, - { - "sim":129.0, - "partner":"3fj8" - }, - { - "sim":129.0, - "partner":"1rg8" - }, - { - "sim":129.0, - "partner":"3baq" - }, { "sim":129.0, "partner":"3fj9" @@ -48427,27 +48489,35 @@ }, { "sim":129.0, - "partner":"1jt4" + "partner":"3ba4" }, { "sim":129.0, - "partner":"3ba4" + "partner":"3fjj" }, { "sim":129.0, - "partner":"3fjj" + "partner":"1jt4" }, { "sim":129.0, "partner":"1jqz" }, { - "sim":128.0, - "partner":"2aqz" + "sim":129.0, + "partner":"3fj8" + }, + { + "sim":129.0, + "partner":"1rg8" + }, + { + "sim":129.0, + "partner":"3baq" }, { "sim":128.0, - "partner":"3ba7" + "partner":"2aqz" }, { "sim":128.0, @@ -48473,6 +48543,10 @@ "sim":128.0, "partner":"3fjk" }, + { + "sim":128.0, + "partner":"3ba7" + }, { "sim":127.0, "partner":"3bad" @@ -48585,10 +48659,6 @@ "sim":97.0, "partner":"2j3p" }, - { - "sim":96.0, - "partner":"2k8r" - }, { "sim":96.0, "partner":"2ki6" @@ -48605,6 +48675,10 @@ "sim":96.0, "partner":"2ki4" }, + { + "sim":96.0, + "partner":"2k8r" + }, { "sim":94.0, "partner":"3k1x" @@ -48767,72 +48841,72 @@ "de novo protein" ], "keywords":[ - "plausible", - "architectures", - "question", - "evolution", - "importance", - "despite", - "demonstrated", - "recapitulating", - "results", - "gene", - "utilized", - "pathway", - "architecture", - "hypothesized", - "via", - "unique", + "central", "threefold", - "route", - "strategy", - "intermediary", - "hypothesis", - "elements", - "experimental", + "exhibit", + "symmetry", + "responsible", "conserved", - "peptide", - "identify", - "fold", + "structural", + "fusion", "agree", - "emergence", - "successfully", - "effectively", - "processes", - "address", - "proposed", + "experimental", "simple", + "extant", + "question", "yet", - "capable", - "provide", + "previously", + "furthermore", + "processes", + "gene", + "via", + "properties", "specific", - "motif", - "symmetric", + "route", + "fold", + "elements", + "importance", + "results", + "provide", + "strategy", + "folding", "precisely", - "evolutionary", - "support", - "furthermore", - "generally", - "central", - "mechanism", - "previously", "model", - "deconstruction", "protein", - "symmetry", - "foldable", - "responsible", + "address", + "successfully", + "utilized", + "architectures", + "deconstruction", + "generally", + "majority", + "symmetric", + "capable", + "motif", + "plausible", + "identify", + "architecture", + "support", + "pathway", + "demonstrated", + "forms", "motifs", - "fusion", - "exhibit", - "extant", + "emergence", + "despite", + "effectively", + "evolution", "compelling", + "intermediary", + "unique", + "mechanism", + "foldable", + "recapitulating", + "proposed", + "hypothesis", "duplication", - "folding", - "structural", - "forms", - "majority", - "properties" + "hypothesized", + "peptide", + "evolutionary" ], "release_date":"2010-12-22", "publication":"\"Experimental support for the evolution of symmetric protein architecture from a simple peptide motif\", Proc.Natl.Acad.Sci.USA, 108, 126-130", @@ -48927,11 +49001,11 @@ }, { "sim":132.0, - "partner":"1jtc" + "partner":"3fjd" }, { "sim":132.0, - "partner":"3fjd" + "partner":"1jtc" }, { "sim":131.0, @@ -48953,10 +49027,6 @@ "sim":131.0, "partner":"3bao" }, - { - "sim":130.0, - "partner":"3baq" - }, { "sim":130.0, "partner":"1k5u" @@ -48998,16 +49068,8 @@ "partner":"1jt5" }, { - "sim":129.0, - "partner":"3ba7" - }, - { - "sim":129.0, - "partner":"3fj8" - }, - { - "sim":129.0, - "partner":"1rg8" + "sim":130.0, + "partner":"3baq" }, { "sim":129.0, @@ -49045,17 +49107,13 @@ "sim":129.0, "partner":"3crg" }, - { - "sim":129.0, - "partner":"1jy0" - }, { "sim":129.0, "partner":"3crh" }, { "sim":129.0, - "partner":"1jt4" + "partner":"1jy0" }, { "sim":129.0, @@ -49071,12 +49129,28 @@ }, { "sim":129.0, - "partner":"1jqz" + "partner":"1jt4" }, { "sim":129.0, "partner":"3fjk" }, + { + "sim":129.0, + "partner":"1jqz" + }, + { + "sim":129.0, + "partner":"3ba7" + }, + { + "sim":129.0, + "partner":"3fj8" + }, + { + "sim":129.0, + "partner":"1rg8" + }, { "sim":128.0, "partner":"2aqz" @@ -49197,10 +49271,6 @@ "sim":98.0, "partner":"2j3p" }, - { - "sim":97.0, - "partner":"2k8r" - }, { "sim":97.0, "partner":"2ki6" @@ -49217,6 +49287,10 @@ "sim":97.0, "partner":"2ki4" }, + { + "sim":97.0, + "partner":"2k8r" + }, { "sim":94.0, "partner":"3k1x" @@ -49379,72 +49453,72 @@ "de novo protein" ], "keywords":[ - "plausible", - "architectures", - "question", - "evolution", - "importance", - "despite", - "demonstrated", - "recapitulating", - "results", - "gene", - "utilized", - "pathway", - "architecture", - "hypothesized", - "via", - "unique", + "central", "threefold", - "route", - "strategy", - "intermediary", - "hypothesis", - "elements", - "experimental", + "exhibit", + "symmetry", + "responsible", "conserved", - "peptide", - "identify", - "fold", + "structural", + "fusion", "agree", - "emergence", - "successfully", - "effectively", - "processes", - "address", - "proposed", + "experimental", "simple", + "extant", + "question", "yet", - "capable", - "provide", + "previously", + "furthermore", + "processes", + "gene", + "via", + "properties", "specific", - "motif", - "symmetric", + "route", + "fold", + "elements", + "importance", + "results", + "provide", + "strategy", + "folding", "precisely", - "evolutionary", - "support", - "furthermore", - "generally", - "central", - "mechanism", - "previously", "model", - "deconstruction", "protein", - "symmetry", - "foldable", - "responsible", + "address", + "successfully", + "utilized", + "architectures", + "deconstruction", + "generally", + "majority", + "symmetric", + "capable", + "motif", + "plausible", + "identify", + "architecture", + "support", + "pathway", + "demonstrated", + "forms", "motifs", - "fusion", - "exhibit", - "extant", + "emergence", + "despite", + "effectively", + "evolution", "compelling", + "intermediary", + "unique", + "mechanism", + "foldable", + "recapitulating", + "proposed", + "hypothesis", "duplication", - "folding", - "structural", - "forms", - "majority", - "properties" + "hypothesized", + "peptide", + "evolutionary" ], "release_date":"2010-12-22", "publication":"\"Experimental support for the evolution of symmetric protein architecture from a simple peptide motif\", Proc.Natl.Acad.Sci.USA, 108, 126-130", @@ -49539,11 +49613,11 @@ }, { "sim":129.0, - "partner":"1jtc" + "partner":"3fjd" }, { "sim":129.0, - "partner":"3fjd" + "partner":"1jtc" }, { "sim":129.0, @@ -49581,10 +49655,6 @@ "sim":128.0, "partner":"3bao" }, - { - "sim":127.0, - "partner":"3fj8" - }, { "sim":127.0, "partner":"2hw9" @@ -49618,16 +49688,8 @@ "partner":"1jt4" }, { - "sim":126.0, - "partner":"3ba7" - }, - { - "sim":126.0, - "partner":"1rg8" - }, - { - "sim":126.0, - "partner":"3baq" + "sim":127.0, + "partner":"3fj8" }, { "sim":126.0, @@ -49685,13 +49747,25 @@ "sim":126.0, "partner":"3fjj" }, + { + "sim":126.0, + "partner":"3fjk" + }, { "sim":126.0, "partner":"1jqz" }, { "sim":126.0, - "partner":"3fjk" + "partner":"3ba7" + }, + { + "sim":126.0, + "partner":"1rg8" + }, + { + "sim":126.0, + "partner":"3baq" }, { "sim":125.0, @@ -49805,10 +49879,6 @@ "sim":94.0, "partner":"2uus" }, - { - "sim":94.0, - "partner":"2k8r" - }, { "sim":94.0, "partner":"2ki6" @@ -49825,6 +49895,10 @@ "sim":94.0, "partner":"2ki4" }, + { + "sim":94.0, + "partner":"2k8r" + }, { "sim":94.0, "partner":"2j3p" @@ -49991,72 +50065,72 @@ "de novo protein" ], "keywords":[ - "plausible", - "architectures", - "question", - "evolution", - "importance", - "despite", - "demonstrated", - "recapitulating", - "results", - "gene", - "utilized", - "pathway", - "architecture", - "hypothesized", - "via", - "unique", + "central", "threefold", - "route", - "strategy", - "intermediary", - "hypothesis", - "elements", - "experimental", + "exhibit", + "symmetry", + "responsible", "conserved", - "peptide", - "identify", - "fold", + "structural", + "fusion", "agree", - "emergence", - "successfully", - "effectively", - "processes", - "address", - "proposed", + "experimental", "simple", + "extant", + "question", "yet", - "capable", - "provide", + "previously", + "furthermore", + "processes", + "gene", + "via", + "properties", "specific", - "motif", - "symmetric", + "route", + "fold", + "elements", + "importance", + "results", + "provide", + "strategy", + "folding", "precisely", - "evolutionary", - "support", - "furthermore", - "generally", - "central", - "mechanism", - "previously", "model", - "deconstruction", "protein", - "symmetry", - "foldable", - "responsible", + "address", + "successfully", + "utilized", + "architectures", + "deconstruction", + "generally", + "majority", + "symmetric", + "capable", + "motif", + "plausible", + "identify", + "architecture", + "support", + "pathway", + "demonstrated", + "forms", "motifs", - "fusion", - "exhibit", - "extant", + "emergence", + "despite", + "effectively", + "evolution", "compelling", + "intermediary", + "unique", + "mechanism", + "foldable", + "recapitulating", + "proposed", + "hypothesis", "duplication", - "folding", - "structural", - "forms", - "majority", - "properties" + "hypothesized", + "peptide", + "evolutionary" ], "release_date":"2010-12-22", "publication":"\"Experimental support for the evolution of symmetric protein architecture from a simple peptide motif\", Proc.Natl.Acad.Sci.USA, 108, 126-130", @@ -50089,11 +50163,11 @@ "seq_thr_sim_designed":[ { "sim":302.0, - "partner":"3o4b" + "partner":"3o4d" }, { "sim":302.0, - "partner":"3o4d" + "partner":"3o4b" }, { "sim":292.0, @@ -50151,11 +50225,11 @@ }, { "sim":129.0, - "partner":"1jtc" + "partner":"3fjd" }, { "sim":129.0, - "partner":"3fjd" + "partner":"1jtc" }, { "sim":128.0, @@ -50197,18 +50271,6 @@ "sim":127.0, "partner":"1jt3" }, - { - "sim":126.0, - "partner":"3fj8" - }, - { - "sim":126.0, - "partner":"1rg8" - }, - { - "sim":126.0, - "partner":"3baq" - }, { "sim":126.0, "partner":"3fj9" @@ -50265,17 +50327,13 @@ "sim":126.0, "partner":"3crg" }, - { - "sim":126.0, - "partner":"1jy0" - }, { "sim":126.0, "partner":"3crh" }, { "sim":126.0, - "partner":"1jt4" + "partner":"1jy0" }, { "sim":126.0, @@ -50289,17 +50347,29 @@ "sim":126.0, "partner":"3fjj" }, + { + "sim":126.0, + "partner":"1jt4" + }, { "sim":126.0, "partner":"1jqz" }, { - "sim":125.0, - "partner":"2aqz" + "sim":126.0, + "partner":"3fj8" + }, + { + "sim":126.0, + "partner":"1rg8" + }, + { + "sim":126.0, + "partner":"3baq" }, { "sim":125.0, - "partner":"3ba7" + "partner":"2aqz" }, { "sim":125.0, @@ -50313,6 +50383,10 @@ "sim":125.0, "partner":"3fjk" }, + { + "sim":125.0, + "partner":"3ba7" + }, { "sim":124.0, "partner":"3bav" @@ -50417,10 +50491,6 @@ "sim":93.0, "partner":"2uus" }, - { - "sim":93.0, - "partner":"2k8r" - }, { "sim":93.0, "partner":"2ki6" @@ -50437,6 +50507,10 @@ "sim":93.0, "partner":"2ki4" }, + { + "sim":93.0, + "partner":"2k8r" + }, { "sim":93.0, "partner":"2j3p" @@ -50549,7 +50623,7 @@ ], "seq_max_sim_designed":{ "sim":302.0, - "partner":"3o4b" + "partner":"3o4d" }, "seq_max_sim_natural":{ "sim":134.0, @@ -50603,72 +50677,72 @@ "de novo protein" ], "keywords":[ - "plausible", - "architectures", - "question", - "evolution", - "importance", - "despite", - "demonstrated", - "recapitulating", - "results", - "gene", - "utilized", - "pathway", - "architecture", - "hypothesized", - "via", - "unique", + "central", "threefold", - "route", - "strategy", - "intermediary", - "hypothesis", - "elements", - "experimental", + "exhibit", + "symmetry", + "responsible", "conserved", - "peptide", - "identify", - "fold", + "structural", + "fusion", "agree", - "emergence", - "successfully", - "effectively", - "processes", - "address", - "proposed", + "experimental", "simple", + "extant", + "question", "yet", - "capable", - "provide", + "previously", + "furthermore", + "processes", + "gene", + "via", + "properties", "specific", - "motif", - "symmetric", + "route", + "fold", + "elements", + "importance", + "results", + "provide", + "strategy", + "folding", "precisely", - "evolutionary", - "support", - "furthermore", - "generally", - "central", - "mechanism", - "previously", "model", - "deconstruction", "protein", - "symmetry", - "foldable", - "responsible", + "address", + "successfully", + "utilized", + "architectures", + "deconstruction", + "generally", + "majority", + "symmetric", + "capable", + "motif", + "plausible", + "identify", + "architecture", + "support", + "pathway", + "demonstrated", + "forms", "motifs", - "fusion", - "exhibit", - "extant", + "emergence", + "despite", + "effectively", + "evolution", "compelling", + "intermediary", + "unique", + "mechanism", + "foldable", + "recapitulating", + "proposed", + "hypothesis", "duplication", - "folding", - "structural", - "forms", - "majority", - "properties" + "hypothesized", + "peptide", + "evolutionary" ], "release_date":"2010-12-22", "publication":"\"Experimental support for the evolution of symmetric protein architecture from a simple peptide motif\", Proc.Natl.Acad.Sci.USA, 108, 126-130", @@ -50763,11 +50837,11 @@ }, { "sim":129.0, - "partner":"1jtc" + "partner":"3fjd" }, { "sim":129.0, - "partner":"3fjd" + "partner":"1jtc" }, { "sim":129.0, @@ -50805,10 +50879,6 @@ "sim":128.0, "partner":"3bao" }, - { - "sim":127.0, - "partner":"3fj8" - }, { "sim":127.0, "partner":"2hw9" @@ -50842,16 +50912,8 @@ "partner":"1jt4" }, { - "sim":126.0, - "partner":"3ba7" - }, - { - "sim":126.0, - "partner":"1rg8" - }, - { - "sim":126.0, - "partner":"3baq" + "sim":127.0, + "partner":"3fj8" }, { "sim":126.0, @@ -50909,13 +50971,25 @@ "sim":126.0, "partner":"3fjj" }, + { + "sim":126.0, + "partner":"3fjk" + }, { "sim":126.0, "partner":"1jqz" }, { "sim":126.0, - "partner":"3fjk" + "partner":"3ba7" + }, + { + "sim":126.0, + "partner":"1rg8" + }, + { + "sim":126.0, + "partner":"3baq" }, { "sim":125.0, @@ -51029,10 +51103,6 @@ "sim":94.0, "partner":"2uus" }, - { - "sim":94.0, - "partner":"2k8r" - }, { "sim":94.0, "partner":"2ki6" @@ -51049,6 +51119,10 @@ "sim":94.0, "partner":"2ki4" }, + { + "sim":94.0, + "partner":"2k8r" + }, { "sim":94.0, "partner":"2j3p" @@ -51219,72 +51293,72 @@ "de novo protein" ], "keywords":[ - "plausible", - "architectures", - "question", - "evolution", - "importance", - "despite", - "demonstrated", - "recapitulating", - "results", - "gene", - "utilized", - "pathway", - "architecture", - "hypothesized", - "via", - "unique", + "central", "threefold", - "route", - "strategy", - "intermediary", - "hypothesis", - "elements", - "experimental", + "exhibit", + "symmetry", + "responsible", "conserved", - "peptide", - "identify", - "fold", + "structural", + "fusion", "agree", - "emergence", - "successfully", - "effectively", - "processes", - "address", - "proposed", + "experimental", "simple", + "extant", + "question", "yet", - "capable", - "provide", + "previously", + "furthermore", + "processes", + "gene", + "via", + "properties", "specific", - "motif", - "symmetric", + "route", + "fold", + "elements", + "importance", + "results", + "provide", + "strategy", + "folding", "precisely", - "evolutionary", - "support", - "furthermore", - "generally", - "central", - "mechanism", - "previously", "model", - "deconstruction", "protein", - "symmetry", - "foldable", - "responsible", + "address", + "successfully", + "utilized", + "architectures", + "deconstruction", + "generally", + "majority", + "symmetric", + "capable", + "motif", + "plausible", + "identify", + "architecture", + "support", + "pathway", + "demonstrated", + "forms", "motifs", - "fusion", - "exhibit", - "extant", + "emergence", + "despite", + "effectively", + "evolution", "compelling", + "intermediary", + "unique", + "mechanism", + "foldable", + "recapitulating", + "proposed", + "hypothesis", "duplication", - "folding", - "structural", - "forms", - "majority", - "properties" + "hypothesized", + "peptide", + "evolutionary" ], "release_date":"2010-12-22", "publication":"\"Experimental support for the evolution of symmetric protein architecture from a simple peptide motif\", Proc.Natl.Acad.Sci.USA, 108, 126-130", @@ -51379,11 +51453,11 @@ }, { "sim":98.0, - "partner":"1jtc" + "partner":"3fjd" }, { "sim":98.0, - "partner":"3fjd" + "partner":"1jtc" }, { "sim":98.0, @@ -51405,10 +51479,6 @@ "sim":97.0, "partner":"3fji" }, - { - "sim":96.0, - "partner":"3baq" - }, { "sim":96.0, "partner":"2hwa" @@ -51435,11 +51505,11 @@ }, { "sim":96.0, - "partner":"1jt3" + "partner":"3crh" }, { "sim":96.0, - "partner":"3crh" + "partner":"1jt3" }, { "sim":96.0, @@ -51454,16 +51524,8 @@ "partner":"1jt5" }, { - "sim":95.0, - "partner":"3ba7" - }, - { - "sim":95.0, - "partner":"3fj8" - }, - { - "sim":95.0, - "partner":"1rg8" + "sim":96.0, + "partner":"3baq" }, { "sim":95.0, @@ -51521,13 +51583,17 @@ "sim":95.0, "partner":"1jy0" }, + { + "sim":95.0, + "partner":"3fjj" + }, { "sim":95.0, "partner":"1jt4" }, { "sim":95.0, - "partner":"3fjj" + "partner":"3fjk" }, { "sim":95.0, @@ -51535,7 +51601,15 @@ }, { "sim":95.0, - "partner":"3fjk" + "partner":"3ba7" + }, + { + "sim":95.0, + "partner":"3fj8" + }, + { + "sim":95.0, + "partner":"1rg8" }, { "sim":94.0, @@ -51633,10 +51707,6 @@ "sim":87.0, "partner":"3jut" }, - { - "sim":87.0, - "partner":"2k8r" - }, { "sim":87.0, "partner":"2ki6" @@ -51653,6 +51723,10 @@ "sim":87.0, "partner":"2ki4" }, + { + "sim":87.0, + "partner":"2k8r" + }, { "sim":87.0, "partner":"2rq9" @@ -51755,13 +51829,13 @@ } ], "struct_thr_sim_designed":[ - { - "sim":0.9541000128, - "partner":"3o4c" - }, { "sim":0.9501000047, "partner":"3o4b" + }, + { + "sim":0.9541000128, + "partner":"3o4c" } ], "struct_thr_sim_natural":[ @@ -51819,79 +51893,79 @@ ], "subtitle":"Crystal structure of monofoil-4p homo-trimer: de novo designed monomer trefoil-fold sub-domain which forms homo-trimer assembly", "tags":[ - "function-competent only", + "synthetic protein", + "de novo protein", "beta-trefoil", "trefoil-fold", - "synthetic protein", - "de novo protein" + "function-competent only" ], "keywords":[ - "plausible", - "architectures", - "question", - "evolution", - "importance", - "despite", - "demonstrated", - "recapitulating", - "results", - "gene", - "utilized", - "pathway", - "architecture", - "hypothesized", - "via", - "unique", + "central", "threefold", - "route", - "strategy", - "intermediary", - "hypothesis", - "elements", - "experimental", + "exhibit", + "symmetry", + "responsible", "conserved", - "peptide", - "identify", - "fold", + "structural", + "fusion", "agree", - "emergence", - "successfully", - "effectively", - "processes", - "address", - "proposed", + "experimental", "simple", + "extant", + "question", "yet", - "capable", - "provide", + "previously", + "furthermore", + "processes", + "gene", + "via", + "properties", "specific", - "motif", - "symmetric", + "route", + "fold", + "elements", + "importance", + "results", + "provide", + "strategy", + "folding", "precisely", - "evolutionary", - "support", - "furthermore", - "generally", - "central", - "mechanism", - "previously", "model", - "deconstruction", "protein", - "symmetry", - "foldable", - "responsible", + "address", + "successfully", + "utilized", + "architectures", + "deconstruction", + "generally", + "majority", + "symmetric", + "capable", + "motif", + "plausible", + "identify", + "architecture", + "support", + "pathway", + "demonstrated", + "forms", "motifs", - "fusion", - "exhibit", - "extant", + "emergence", + "despite", + "effectively", + "evolution", "compelling", + "intermediary", + "unique", + "mechanism", + "foldable", + "recapitulating", + "proposed", + "hypothesis", "duplication", - "folding", - "structural", - "forms", - "majority", - "properties" + "hypothesized", + "peptide", + "evolutionary" ], "release_date":"2010-12-22", "publication":"\"Experimental support for the evolution of symmetric protein architecture from a simple peptide motif\", Proc.Natl.Acad.Sci.USA, 108, 126-130", @@ -51936,11 +52010,11 @@ }, { "sim":98.0, - "partner":"3o4b" + "partner":"3o4c" }, { "sim":98.0, - "partner":"3o4c" + "partner":"3o4b" }, { "sim":96.0, @@ -51970,19 +52044,19 @@ }, { "sim":70.0, - "partner":"1jt7" + "partner":"3fgm" }, { "sim":70.0, - "partner":"3fgm" + "partner":"1jt7" }, { "sim":70.0, - "partner":"1jtc" + "partner":"3fjd" }, { "sim":70.0, - "partner":"3fjd" + "partner":"1jtc" }, { "sim":70.0, @@ -52028,22 +52102,6 @@ "sim":68.0, "partner":"1q04" }, - { - "sim":67.0, - "partner":"3ba7" - }, - { - "sim":67.0, - "partner":"3fj8" - }, - { - "sim":67.0, - "partner":"1rg8" - }, - { - "sim":67.0, - "partner":"3baq" - }, { "sim":67.0, "partner":"3fj9" @@ -52104,6 +52162,10 @@ "sim":67.0, "partner":"3crg" }, + { + "sim":67.0, + "partner":"3crh" + }, { "sim":67.0, "partner":"1jy0" @@ -52114,23 +52176,27 @@ }, { "sim":67.0, - "partner":"3crh" + "partner":"3ba4" }, { "sim":67.0, - "partner":"1jt4" + "partner":"3cri" }, { "sim":67.0, - "partner":"3ba4" + "partner":"3fjj" }, { "sim":67.0, - "partner":"3cri" + "partner":"1jt4" }, { "sim":67.0, - "partner":"3fjj" + "partner":"3fjk" + }, + { + "sim":67.0, + "partner":"1jt5" }, { "sim":67.0, @@ -52138,11 +52204,19 @@ }, { "sim":67.0, - "partner":"1jt5" + "partner":"3ba7" }, { "sim":67.0, - "partner":"3fjk" + "partner":"3fj8" + }, + { + "sim":67.0, + "partner":"1rg8" + }, + { + "sim":67.0, + "partner":"3baq" }, { "sim":66.0, @@ -52248,10 +52322,6 @@ "sim":59.0, "partner":"3cu1" }, - { - "sim":59.0, - "partner":"2k8r" - }, { "sim":59.0, "partner":"2ki6" @@ -52268,6 +52338,10 @@ "sim":59.0, "partner":"2ki4" }, + { + "sim":59.0, + "partner":"2k8r" + }, { "sim":59.0, "partner":"1evt" @@ -52478,73 +52552,73 @@ ], "subtitle":"Structure of an amyloid forming peptide klvffa from amyloid beta in complex with orange g", "tags":[ - "protein fibril", - "amyloid-like protofibril" + "amyloid-like protofibril", + "protein fibril" ], "keywords":[ - "great", - "aid", + "molecule", + "complex", + "fibers", + "disease", + "pairs", "observation", - "lysine", - "despite", - "chains", + "negatively", "molecular", - "aggregation", - "proteins", - "associated", - "drift", - "frameworks", - "fibers", + "design", + "atomic", + "microcrystallography", + "lysine", + "binders", + "structures", + "research", + "effort", "complexes", - "treating", - "nonspecific", - "suggest", - "specifically", - "involved", - "contrast", - "challenge", - "drugs", + "fiber", "apolar", - "intensive", - "along", - "negatively", - "remains", - "diagnosing", - "small", - "provide", + "drift", + "side", "alzheimer", - "binders", - "binds", - "adjacent", - "parallel", + "remains", + "roughly", + "specifically", + "aggregation", + "great", + "nonspecific", "determined", - "effort", - "fiber", + "treating", + "provide", + "frameworks", + "protein", + "axis", + "diseases", + "proteins", + "binding", + "molecules", "sheets", - "design", + "contrast", + "diagnosing", + "segments", + "charged", "amyloid", - "structures", - "binding", - "protein", + "parallel", + "small", + "suggest", + "drugs", + "despite", + "along", "present", - "complex", - "microcrystallography", - "charged", "variety", - "segments", - "atomic", - "pairs", - "diseases", - "research", - "axis", + "binds", + "chains", + "involved", + "associated", + "challenge", + "consist", + "adjacent", "diagnostics", - "side", - "molecules", - "consistent", - "disease", - "roughly", - "molecule", - "consist" + "intensive", + "aid", + "consistent" ], "release_date":"2011-07-06", "publication":"\"Towards a pharmacophore for amyloid\", Plos Biol., 9, e1001080-e1001080", @@ -52666,79 +52740,79 @@ ], "subtitle":"Structure of an amyloid forming peptide klvffa from amyloid beta, alternate polymorph ii", "tags":[ - "protein fibril", - "amyloid-like protofibril" + "amyloid-like protofibril", + "protein fibril" ], "keywords":[ - "elucidate", - "containing", - "protofibers", - "structural", - "combining", - "allows", - "oligomers", - "microcrystal", - "eight", - "molecular", - "studies", - "detail", - "us", - "models", - "accessible", "a\u03b2", - "steric", + "reveal", + "form", + "lifetimes", "fundamental", + "elucidate", + "disease", "fibers", - "pathogenesis", - "lifetimes", - "modes", - "termed", + "exhibit", + "models", + "molecular", + "steric", + "structural", + "hallmark", + "atomic", "main", - "senile", - "polydisperse", + "structures", + "fiber", + "microcrystal", "determination", + "us", "information", "polymorphic", - "histological", - "reveal", - "short", - "offering", + "oligomers", + "pathological", "alzheimer", - "toxicities", - "zippers", - "nature", - "repertoire", "constituent", - "determined", - "assemble", - "hallmark", - "polymorphism", "plaques", - "mechanism", - "several", - "characterization", - "fiber", - "structures", - "frustrated", - "previous", - "propose", + "modes", + "combining", + "accessible", + "contribute", + "determined", + "new", + "short", + "termed", "nmr", - "variety", - "segments", - "atomic", - "pairs", - "cellular", - "exhibit", + "histological", + "propose", + "nature", + "biophysical", + "polymorphism", "understanding", - "form", + "toxicities", + "detail", "molecules", - "pathological", - "disease", + "eight", + "cellular", + "characterization", + "several", + "allows", + "segments", + "zippers", + "repertoire", + "polydisperse", + "studies", + "variety", + "frustrated", "aggregates", - "contribute", - "biophysical", - "new", - "range" + "assemble", + "range", + "mechanism", + "containing", + "offering", + "pathogenesis", + "senile", + "pairs", + "protofibers", + "previous" ], "release_date":"2011-08-31", "publication":"\"Molecular basis for amyloid-{beta} polymorphism\", Proc.Natl.Acad.Sci.USA, 108, 16938-16943", @@ -52841,106 +52915,106 @@ "subtitle":"Integrin binding collagen peptide", "tags":[ "integrin recognition", - "collagen", "de novo protein", - "integrin alpha 1 beta 1" + "integrin alpha 1 beta 1", + "collagen" ], "keywords":[ - "thermal", - "established", - "pisa", - "58", - "moleculesmodified", - "atom", - "generated", - "validation", - "modelled", - "reportbiological", - "park", - "software", - "enhanced", - "structure", - "identity70", - "430", - "typeformula2d", - "c20synthetic", - "1moleculechains", - "a3", - "centre", - "generating", - "identity95", - "proteins", - "stoichiometry", - "biomolecular", - "contenttotal", - "unique", - "entity", - "similar", - "uniqueidchains", - "hypa", - "constructmutation", - "annotations", - "sciences", - "h", - "kda", - "nottingham", - "identity50", - "h9", "collagen", - "diagramparenthypquery", - "sequencesmall", - "identitysequence", - "assembly", - "lengthorganismdetailsimagesynthetic", + "0", + "school", + "residue", + "protein", + "helical", + "electron", "authors", "affiliation", - "linkingc5", - "data", - "deposited", - "annotationsexpandreference", - "1", - "cuaac", - "school", - "assembliesbiological", - "synthesis", - "unit", - "60", - "university", + "annotations", "weight", - "helical", - "reportglobal", - "assigned", - "symmetry", - "sequence", + "b", + "annotationsexpandreference", + "h9", "lessfind", - "count", + "global", "homo", - "identity90", - "3d", - "peptidea", - "density", "chains", - "groups", - "n", - "o3proexperimental", - "identity100", - "peptides", - "modular", - "electron", - "previousnextmacromolecule", - "residues", + "nottingham", + "centre", + "similar", + "identity95", "reaction", - "pharmacy", + "deposited", + "university", + "sequencesmall", + "assembliesbiological", + "lengthorganismdetailsimagesynthetic", + "residues", + "thermal", + "proteins", + "reportbiological", + "modular", + "typeformula2d", + "established", + "density", "clusters30", + "identity50", + "1", + "identity70", + "pharmacy", + "contenttotal", + "symmetry", + "enhanced", + "modelled", + "peptidea", + "a3", "id", + "assembly", + "synthesis", + "n", + "atom", + "groups", "explore", - "b", - "protein", - "residue", - "0", + "biomolecular", + "kda", + "430", + "sequence", + "peptides", + "generating", + "3d", + "unique", + "identity100", + "validation", + "sciences", + "identitysequence", + "h", + "constructmutation", "clicked", - "global", - "1macromoleculesfind" + "reportglobal", + "1moleculechains", + "cuaac", + "c20synthetic", + "linkingc5", + "count", + "structure", + "park", + "hypa", + "identity90", + "unit", + "assigned", + "software", + "diagramparenthypquery", + "pisa", + "stoichiometry", + "o3proexperimental", + "uniqueidchains", + "generated", + "60", + "entity", + "58", + "data", + "1macromoleculesfind", + "moleculesmodified", + "previousnextmacromolecule" ], "release_date":"2011-01-12", "publication":"\"End-stapled homo and hetero collagen triple helices: a click chemistry approach\", Chem.Commun.(Camb.), 47, 2589-2591", @@ -53232,100 +53306,100 @@ ], "subtitle":"Hydrolytic catalysis and structural stabilization in a designed metalloprotein", "tags":[ - "mercury(ii) binding protein", "l-penicillamine", "de novo protein", "zinc(ii) binding protein", + "mercury(ii) binding protein", "parallel three-stranded coiled coil" ], "keywords":[ - "least", - "containing", - "analysis", - "many", - "part", - "providing", + "apopeptide", + "kinetic", + "hydrolytic", + "structural", "complexes", - "metal", - "ions", - "challenge", - "crystallography", - "designed", + "well", + "pnpa", + "within", + "characteristic", + "protein", + "reproducing", + "electron", + "novo", + "catalytic", + "two", "hg", - "metalloenzyme", - "features", - "ii", - "synthetic", "zn", - "occurs", - "acetate", - "caii", + "catalyses", + "metal", + "reactions", + "metals", + "residues", + "although", + "functions", + "displays", + "stability", "proteins", - "de", + "part", + "ions", + "several", + "2", "enzymes", - "although", - "pnpa", - "less", - "necessary", - "hydrolytic", - "better", - "comparable", - "efficiency", - "natural", + "contain", "future", + "features", + "caii", + "ultimate", "ca", - "apopeptide", + "miniscule", "exhibit", - "co", - "first", - "stability", - "anhydrase", - "hydrolysis", - "reveals", + "metalloenzyme", + "design", + "similarly", + "metalloenzymes", + "provides", + "natural", + "absence", + "different", "carbonic", - "catalytic", - "hydration", - "displays", - "artificial", - "reactions", - "functions", + "metallohydrolase", + "anhydrase", + "least", + "compares", "shown", - "activity", - "transfer", - "provides", - "several", - "observed", - "design", - "metals", + "reveals", "present", + "hydration", + "designed", + "co", + "analysis", + "many", + "one", "histidine", - "compares", - "kinetic", - "structural", + "providing", + "observed", + "de", + "first", + "hydrolysis", + "comparable", "important", - "characteristic", + "synthetic", + "occurs", + "crystallography", "ion", - "one", - "reproducing", - "novo", - "similarly", - "metallohydrolase", - "human", - "ultimate", - "electron", - "well", - "different", - "residues", - "two", - "absence", - "protein", - "miniscule", - "2", - "catalyses", + "necessary", "understanding", - "within", - "metalloenzymes", - "contain" + "artificial", + "activity", + "acetate", + "efficiency", + "human", + "challenge", + "less", + "containing", + "better", + "transfer", + "ii" ], "release_date":"2011-11-30", "publication":"\"Hydrolytic catalysis and structural stabilization in a designed metalloprotein\", Nat Chem, 4, 118-123", @@ -53373,10 +53447,6 @@ "sim":0.9840999842, "partner":"3ljm" }, - { - "sim":0.9715999961, - "partner":"1cos" - }, { "sim":0.9854999781, "partner":"5k92" @@ -53390,24 +53460,12 @@ "partner":"2x6p" }, { - "sim":0.9793999791, - "partner":"5u9u" - }, - { - "sim":0.9682000279, - "partner":"1coi" - }, - { - "sim":0.9818000197, - "partner":"6v5i" - }, - { - "sim":0.9693999887, - "partner":"6v5g" + "sim":0.9715999961, + "partner":"1cos" }, { - "sim":0.951300025, - "partner":"5uxt" + "sim":0.9793999791, + "partner":"5u9u" }, { "sim":0.9620000124, @@ -53425,9 +53483,25 @@ "sim":0.9649999738, "partner":"7n2z" }, + { + "sim":0.9682000279, + "partner":"1coi" + }, { "sim":0.9616000056, "partner":"5kb2" + }, + { + "sim":0.9818000197, + "partner":"6v5i" + }, + { + "sim":0.9693999887, + "partner":"6v5g" + }, + { + "sim":0.951300025, + "partner":"5uxt" } ], "struct_thr_sim_natural":[ @@ -53507,86 +53581,86 @@ ], "subtitle":"Crystal structure of designed 3-fold symmetric protein, threefoil", "tags":[ - "beta-trefoil", - "sugar binding", - "symmetric design", "de novo protein", - "engineered module" + "engineered module", + "sugar binding", + "beta-trefoil", + "symmetric design" ], "keywords":[ - "stability", - "thermal", - "analysis", - "past", - "evolution", + "independently", + "form", + "performs", + "simply", "remarkably", - "regenerating", - "proteins", - "reveals", - "newly", - "reflect", - "unexpectedly", + "analysis", "identity", - "multivalent", - "via", - "common", - "performed", - "process", - "globular", - "modules", + "symmetry", + "determinants", + "design", + "structural", "origins", - "recurring", - "independently", - "occurred", - "peptide", - "fold", - "repetition", - "abundant", - "relic", - "modular", + "fusion", + "soluble", + "past", + "reconstruction", "perfect", + "relic", + "performed", + "newly", "carbohydrate", - "near", - "highly", - "threefoil", + "via", + "module", + "reflect", + "within", + "fold", "subdomain", - "little", - "symmetric", - "folds", - "frequency", - "evolutionary", - "determinants", - "ancient", + "recurring", "addition", - "implications", - "simply", - "mechanism", - "reconstruction", - "design", "findings", - "binding", + "thermal", "protein", - "numerous", - "soluble", - "performs", - "ongoing", - "module", - "existing", - "symmetry", + "globular", + "stability", + "known", + "understanding", + "modules", + "proteins", + "symmetric", + "presumed", + "internal", + "little", + "process", + "binding", + "unexpectedly", + "primary", + "frequency", + "modular", + "multivalent", "high", + "ongoing", + "ancient", + "abundant", + "threefoil", "sequence", - "presumed", - "fusion", + "highly", + "common", + "reveals", + "regenerating", + "numerous", + "near", + "evolution", + "repeated", + "existing", + "implications", "physical", - "within", + "mechanism", + "occurred", "computational", - "understanding", - "form", - "primary", - "known", - "repeated", - "internal", - "structural" + "folds", + "repetition", + "peptide", + "evolutionary" ], "release_date":"2011-12-21", "publication":"\"Modular evolution and the origins of symmetry: reconstruction of a three-fold symmetric globular protein\", Structure, 20, 161-171", @@ -53623,10 +53697,6 @@ } ], "seq_thr_sim_natural":[ - { - "sim":84.0, - "partner":"2d23" - }, { "sim":84.0, "partner":"2d24" @@ -53637,15 +53707,15 @@ }, { "sim":84.0, - "partner":"1isw" + "partner":"1xyf" }, { "sim":84.0, - "partner":"1isx" + "partner":"1isw" }, { "sim":84.0, - "partner":"1xyf" + "partner":"1isx" }, { "sim":84.0, @@ -53687,6 +53757,10 @@ "sim":84.0, "partner":"2d22" }, + { + "sim":84.0, + "partner":"2d23" + }, { "sim":82.0, "partner":"1knl" @@ -53712,7 +53786,7 @@ }, "seq_max_sim_natural":{ "sim":84.0, - "partner":"2d23" + "partner":"2d24" }, "struct_max_sim_designed":{ "sim":0.7814000249, @@ -53766,83 +53840,83 @@ "de novo protein" ], "keywords":[ - "pi", - "require", + "whether", + "concentrations", + "show", + "information", + "question", + "80", + "13", + "comprise", + "biosynthetic", + "within", "results", - "abiogenesis", - "suggest", + "unsolved", + "characteristic", + "folding", + "protein", + "deconstruction", + "salt", + "produced", + "essential", + "polypeptides", + "two", + "pi", + "10", "questions", + "abiotic", + "resource", + "defines", + "compendium", + "overall", "regarding", - "pathways", - "show", - "proteogenesis", - "approaching", - "concentrations", "proteins", - "syntheses", "process", - "biosynthetic", - "whether", - "alphabet", - "resulting", - "symmetric", - "resource", - "permit", - "essential", "size", - "exhibit", - "cooperatively", + "approaching", "consensus", - "properties", - "investigate", - "versions", - "salt", - "compendium", - "amino", + "suggest", + "contain", + "emergence", "chemical", + "pathways", "substantial", - "abiotic", - "acids", - "information", - "10", - "80", + "investigate", + "set", "12", - "produced", - "reduced", - "deconstruction", - "cooperative", - "defines", - "high", - "unsolved", + "exhibit", + "halophile", "extant", - "identifies", + "different", + "environment", + "properties", + "fold", + "amino", + "reduced", + "symmetric", "formation", - "comprise", - "characteristic", - "13", + "permit", "plausible", + "alphabet", + "types", + "versions", + "cooperative", + "cooperatively", + "require", + "acidification", "prebiotic", - "question", + "syntheses", "might", - "overall", - "acidification", - "halophile", - "fold", - "sufficient", - "percentage", - "emergence", - "different", - "two", + "resulting", + "abiogenesis", "primitive", - "set", - "protein", + "high", + "proteogenesis", + "acids", + "sufficient", + "identifies", "foldable", - "types", - "environment", - "within", - "polypeptides", - "folding", - "contain" + "percentage" ], "release_date":"2012-01-11", "publication":"\"Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein\", Proc.Natl.Acad.Sci.USA, 110, 2135-2139", @@ -53954,87 +54028,87 @@ "subtitle":"Crystal structure of symfoil-4p\/pv1: de novo designed beta-trefoil architecture with symmetric primary structure, primitive version 1", "tags":[ "beta-trefoil", - "beta-terfoil", - "de novo protein" + "de novo protein", + "beta-terfoil" ], "keywords":[ - "pi", - "require", + "whether", + "concentrations", + "show", + "information", + "question", + "80", + "13", + "comprise", + "biosynthetic", + "within", "results", - "abiogenesis", - "suggest", + "unsolved", + "characteristic", + "folding", + "protein", + "deconstruction", + "salt", + "produced", + "essential", + "polypeptides", + "two", + "pi", + "10", "questions", + "abiotic", + "resource", + "defines", + "compendium", + "overall", "regarding", - "pathways", - "show", - "proteogenesis", - "approaching", - "concentrations", "proteins", - "syntheses", "process", - "biosynthetic", - "whether", - "alphabet", - "resulting", - "symmetric", - "resource", - "permit", - "essential", "size", - "exhibit", - "cooperatively", + "approaching", "consensus", - "properties", - "investigate", - "versions", - "salt", - "compendium", - "amino", + "suggest", + "contain", + "emergence", "chemical", + "pathways", "substantial", - "abiotic", - "acids", - "information", - "10", - "80", + "investigate", + "set", "12", - "produced", - "reduced", - "deconstruction", - "cooperative", - "defines", - "high", - "unsolved", + "exhibit", + "halophile", "extant", - "identifies", + "different", + "environment", + "properties", + "fold", + "amino", + "reduced", + "symmetric", "formation", - "comprise", - "characteristic", - "13", + "permit", "plausible", + "alphabet", + "types", + "versions", + "cooperative", + "cooperatively", + "require", + "acidification", "prebiotic", - "question", + "syntheses", "might", - "overall", - "acidification", - "halophile", - "fold", - "sufficient", - "percentage", - "emergence", - "different", - "two", + "resulting", + "abiogenesis", "primitive", - "set", - "protein", + "high", + "proteogenesis", + "acids", + "sufficient", + "identifies", "foldable", - "types", - "environment", - "within", - "polypeptides", - "folding", - "contain" + "percentage" ], "release_date":"2012-01-11", "publication":"\"Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein\", Proc.Natl.Acad.Sci.USA, 110, 2135-2139", @@ -54149,83 +54223,83 @@ "de novo protein" ], "keywords":[ - "pi", - "require", + "whether", + "concentrations", + "show", + "information", + "question", + "80", + "13", + "comprise", + "biosynthetic", + "within", "results", - "abiogenesis", - "suggest", + "unsolved", + "characteristic", + "folding", + "protein", + "deconstruction", + "salt", + "produced", + "essential", + "polypeptides", + "two", + "pi", + "10", "questions", + "abiotic", + "resource", + "defines", + "compendium", + "overall", "regarding", - "pathways", - "show", - "proteogenesis", - "approaching", - "concentrations", "proteins", - "syntheses", "process", - "biosynthetic", - "whether", - "alphabet", - "resulting", - "symmetric", - "resource", - "permit", - "essential", "size", - "exhibit", - "cooperatively", + "approaching", "consensus", - "properties", - "investigate", - "versions", - "salt", - "compendium", - "amino", + "suggest", + "contain", + "emergence", "chemical", + "pathways", "substantial", - "abiotic", - "acids", - "information", - "10", - "80", + "investigate", + "set", "12", - "produced", - "reduced", - "deconstruction", - "cooperative", - "defines", - "high", - "unsolved", + "exhibit", + "halophile", "extant", - "identifies", + "different", + "environment", + "properties", + "fold", + "amino", + "reduced", + "symmetric", "formation", - "comprise", - "characteristic", - "13", + "permit", "plausible", + "alphabet", + "types", + "versions", + "cooperative", + "cooperatively", + "require", + "acidification", "prebiotic", - "question", + "syntheses", "might", - "overall", - "acidification", - "halophile", - "fold", - "sufficient", - "percentage", - "emergence", - "different", - "two", + "resulting", + "abiogenesis", "primitive", - "set", - "protein", + "high", + "proteogenesis", + "acids", + "sufficient", + "identifies", "foldable", - "types", - "environment", - "within", - "polypeptides", - "folding", - "contain" + "percentage" ], "release_date":"2012-01-11", "publication":"\"Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein\", Proc.Natl.Acad.Sci.USA, 110, 2135-2139", @@ -54353,102 +54427,102 @@ ], "subtitle":"Crystal structure of the monobody ysmb-1 bound to yeast sumo", "tags":[ - "smt3", - "yeast small ubiquitin-like modifier", + "de novo protein", "fibronectin type iii", - "de novo protein" + "smt3", + "yeast small ubiquitin-like modifier" ], "keywords":[ - "containing", "largely", - "part", - "nm", - "modifier", - "conjugation", - "challenge", - "conserved", - "sumo2", + "isoform", + "engineering", + "sumoylation", + "yeast", + "individual", + "development", + "homolog", + "sumo", + "regulation", + "differences", "roles", - "designed", - "enhance", - "illustrated", + "protein", + "binding", + "cellular", + "site", + "investigations", "thought", + "motifs", + "major", + "modifier", + "two", + "related", "crystal", - "determined", - "based", - "interactions", - "bind", - "structure", - "inhibitors", - "however", - "generating", "k", - "proteins", - "discriminating", "involved", + "100", + "conjugation", + "sims", + "however", + "discriminating", + "enhance", + "mechanistic", + "due", "family", - "isoform", - "processes", - "remains", - "small", - "highly", + "library", "times", - "arise", - "mechanistic", - "individual", - "400", - "cellular", - "motifs", - "biology", - "uncharacterized", - "mediated", - "first", - "molecules", - "weakly", - "obtained", - "100", - "functional", - "regulation", - "report", - "sumoylation", - "closely", + "bind", + "bound", + "proteins", + "part", + "unexpectedly", "iii", - "engineering", - "monobodies", - "type", + "illustrated", + "scaffold", + "highly", + "small", + "values", + "obtained", "difficulty", - "sumo", + "inhibited", "diverse", - "library", - "values", - "unexpectedly", + "functional", + "biology", + "uncharacterized", + "processes", + "arise", + "approximately", + "nm", + "selective", "also", - "fibronectin", - "human", - "homolog", "humans", - "two", - "due", + "type", + "monobodies", + "weakly", "sumo1", - "approximately", - "sims", - "isoforms", - "scaffold", + "generating", "mechanism", - "selective", - "binding", - "protein", - "bound", - "investigations", - "development", - "differences", + "designed", + "conserved", + "monobody", + "400", + "first", + "based", + "remains", + "structure", + "isoforms", + "report", + "determined", + "closely", + "interactions", + "fibronectin", + "inhibitors", + "molecules", + "sumo2", + "mediated", "distinct", - "yeast", - "major", - "inhibited", - "site", - "related", - "monobody" + "human", + "challenge", + "containing" ], "release_date":"2011-05-11", "publication":"\"Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design\", Proc.Natl.Acad.Sci.USA, 108, 7751-7756", @@ -54689,76 +54763,76 @@ ], "subtitle":"Crystal structure of the de novo designed binding protein hb36.3 in complex the the 1918 influenza virus hemagglutinin", "tags":[ + "hemagglutinin", "viral protein\/de novo protein", "glycoprotein", - "hemagglutinin", "viral protein-de novo protein complex" ], "keywords":[ - "inhibits", - "interfaces", - "general", - "pandemic", - "fusogenic", - "hb80", - "amino", - "proteins", - "virus", - "h1", - "patch", - "1918", - "h1n1", + "affinity", + "designed", + "disembodied", + "surface", + "hemagglutinin", + "complex", + "designing", + "actual", + "design", + "revealed", "conformational", - "low", - "de", - "novo", - "changes", + "interfaces", "conserved", - "disembodied", - "acid", - "ha", - "method", - "designed", - "may", + "1918", + "nearly", "influenza", "interest", - "residues", "used", - "interface", - "induced", - "useful", - "two", + "de", + "therapeutics", + "patch", + "ha", "identified", - "crystal", + "residues", + "h5", + "structure", + "acid", + "stem", + "anchor", + "virus", "target", - "design", "model", - "nanomolar", - "therapeutics", - "bind", + "hb80", "interactions", + "maturation", + "useful", + "bind", + "amino", + "ph", + "pandemic", + "proteins", + "fusogenic", + "binding", + "low", + "changes", + "h1n1", + "may", + "general", + "novo", + "interface", "macromolecule", - "complex", + "favorable", "identical", - "stem", - "designing", - "surface", + "two", + "induced", + "crystal", "describe", - "structure", - "h5", - "revealed", - "maturation", "hb36", + "nanomolar", + "method", "computational", - "anchor", - "favorable", - "ph", + "inhibits", "diagnostics", - "affinity", - "nearly", - "binding", - "hemagglutinin", - "actual" + "h1" ], "release_date":"2011-05-11", "publication":"\"Computational design of proteins targeting the conserved stem region of influenza hemagglutinin\", Science, 332, 816-821", @@ -54892,85 +54966,85 @@ ], "subtitle":"Crystal structure of a parallel 6-helix coiled coil", "tags":[ - "hydrophobic channel", - "kih interactions", "synthetic biology", + "kih interactions", "de novo protein", + "hydrophobic channel", "parallel hexamer" ], "keywords":[ - "layer", - "accepting", - "running", - "chains", - "one", - "proteins", - "represents", - "unique", - "de", - "novo", - "success", - "although", - "combined", - "challenge", - "stable", - "scaffolds", - "acid", - "formidable", - "area", - "channel", + "leucine", "permeable", + "form", + "aspartic", + "engineering", "lined", + "design", + "heterohexamer", "organization", + "hydrophobic", + "one", + "accepting", + "exclusively", + "histidine", "moreover", - "would", - "residues", - "functions", - "provide", - "subdivision", - "repertoire", - "parallel", - "crystal", - "leucine", + "running", + "structures", + "de", + "lumen", + "natural", + "biology", + "represents", "3", - "engineering", + "side", + "area", + "residues", + "structure", + "synthetic", + "within", + "scaffolds", + "acid", + "leads", "polar", - "bundle", - "heterohexamer", - "design", + "new", + "although", + "provide", + "isoleucine", + "functions", + "layer", + "protein", + "formidable", "mutable", + "understanding", + "subdivision", + "combined", + "basis", + "proteins", + "would", + "mutants", "characterization", - "lumen", - "exclusively", - "structures", - "protein", - "synthetic", + "success", + "novo", + "parallel", + "sequence", + "repertoire", "expand", - "isoleucine", + "forms", + "channel", + "solvent", "present", - "hydrophobic", - "basis", - "natural", + "crystal", + "stable", "describe", - "structure", - "water", - "sequence", "exploited", - "biology", - "understanding", - "increase", + "chains", + "challenge", + "unique", + "bundle", "could", - "within", - "histidine", - "aspartic", - "leads", - "mutants", - "form", - "side", + "increase", "biotechnology", - "solvent", - "forms", - "new" + "water" ], "release_date":"2011-11-16", "publication":"\"A de novo peptide hexamer with a mutable channel\", Nat.Chem.Biol., 7, 935-941", @@ -55016,32 +55090,32 @@ "partner":"4h8g" }, { - "sim":1.0, - "partner":"3r46" + "sim":0.9779000282, + "partner":"6q5o" }, { "sim":1.0, - "partner":"3r48" + "partner":"6q5p" }, { - "sim":0.9955000281, - "partner":"4h8m" + "sim":1.0, + "partner":"6q5s" }, { "sim":1.0, - "partner":"6q5p" + "partner":"3r46" }, { - "sim":1.0, - "partner":"6q5s" + "sim":0.9955000281, + "partner":"4h8m" }, { "sim":1.0, - "partner":"6q5j" + "partner":"3r48" }, { - "sim":0.9779000282, - "partner":"6q5o" + "sim":1.0, + "partner":"6q5j" }, { "sim":1.0, @@ -55053,11 +55127,11 @@ }, { "sim":1.0, - "partner":"4h8o" + "partner":"6q5r" }, { "sim":1.0, - "partner":"6q5r" + "partner":"4h8o" }, { "sim":0.9952999949, @@ -55068,56 +55142,52 @@ "partner":"3r47" }, { - "sim":0.9851999879, - "partner":"3r4h" + "sim":0.9684000015, + "partner":"5eoj" }, { - "sim":0.996900022, - "partner":"3r4a" + "sim":0.975300014, + "partner":"5vte" }, { - "sim":0.9739000201, - "partner":"6q5q" + "sim":0.9851999879, + "partner":"3r4h" }, { - "sim":0.9684000015, - "partner":"5eoj" + "sim":0.996900022, + "partner":"3r4a" }, { - "sim":0.975300014, - "partner":"5vte" + "sim":0.9757000208, + "partner":"5eon" }, { "sim":0.9575999975, "partner":"8qac" }, { - "sim":1.0, - "partner":"8qaa" + "sim":0.9739000201, + "partner":"6q5q" }, { - "sim":0.9757000208, - "partner":"5eon" + "sim":1.0, + "partner":"8qaa" }, { "sim":0.9986000061, "partner":"4dzl" }, - { - "sim":1.0, - "partner":"8qab" - }, { "sim":0.9919999838, "partner":"6i1j" }, { "sim":1.0, - "partner":"7qdk" + "partner":"8qab" }, { - "sim":0.9936000109, - "partner":"4dzm" + "sim":1.0, + "partner":"7qdk" }, { "sim":0.9704999924, @@ -55126,6 +55196,10 @@ { "sim":0.9582999945, "partner":"1cos" + }, + { + "sim":0.9936000109, + "partner":"4dzm" } ], "struct_thr_sim_natural":[ @@ -55218,86 +55292,86 @@ ], "subtitle":"Crystal structure of a parallel 6-helix coiled coil cc-hex-d24", "tags":[ - "hydrophobic channel", - "kih interactions", "synthetic biology", + "kih interactions", "de novo protein", - "coiled coil domain", - "parallel hexamer" + "hydrophobic channel", + "parallel hexamer", + "coiled coil domain" ], "keywords":[ - "layer", - "accepting", - "running", - "chains", - "one", - "proteins", - "represents", - "unique", - "de", - "novo", - "success", - "although", - "combined", - "challenge", - "stable", - "scaffolds", - "acid", - "formidable", - "area", - "channel", + "leucine", "permeable", + "form", + "aspartic", + "engineering", "lined", + "design", + "heterohexamer", "organization", + "hydrophobic", + "one", + "accepting", + "exclusively", + "histidine", "moreover", - "would", - "residues", - "functions", - "provide", - "subdivision", - "repertoire", - "parallel", - "crystal", - "leucine", + "running", + "structures", + "de", + "lumen", + "natural", + "biology", + "represents", "3", - "engineering", + "side", + "area", + "residues", + "structure", + "synthetic", + "within", + "scaffolds", + "acid", + "leads", "polar", - "bundle", - "heterohexamer", - "design", + "new", + "although", + "provide", + "isoleucine", + "functions", + "layer", + "protein", + "formidable", "mutable", + "understanding", + "subdivision", + "combined", + "basis", + "proteins", + "would", + "mutants", "characterization", - "lumen", - "exclusively", - "structures", - "protein", - "synthetic", + "success", + "novo", + "parallel", + "sequence", + "repertoire", "expand", - "isoleucine", + "forms", + "channel", + "solvent", "present", - "hydrophobic", - "basis", - "natural", + "crystal", + "stable", "describe", - "structure", - "water", - "sequence", "exploited", - "biology", - "understanding", - "increase", + "chains", + "challenge", + "unique", + "bundle", "could", - "within", - "histidine", - "aspartic", - "leads", - "mutants", - "form", - "side", + "increase", "biotechnology", - "solvent", - "forms", - "new" + "water" ], "release_date":"2011-11-16", "publication":"\"A de novo peptide hexamer with a mutable channel\", Nat.Chem.Biol., 7, 935-941", @@ -55334,6 +55408,10 @@ ], "struct_thr_sim_designed":[ + { + "sim":1.0, + "partner":"3r48" + }, { "sim":1.0, "partner":"4h8m" @@ -55346,10 +55424,6 @@ "sim":0.996999979, "partner":"6q5n" }, - { - "sim":1.0, - "partner":"3r48" - }, { "sim":1.0, "partner":"3r3k" @@ -55422,14 +55496,14 @@ "sim":0.9523000121, "partner":"5eoj" }, - { - "sim":0.9575999975, - "partner":"5vte" - }, { "sim":1.0, "partner":"8qab" }, + { + "sim":0.9575999975, + "partner":"5vte" + }, { "sim":0.9923999906, "partner":"6i1j" @@ -55454,7 +55528,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"6q5j" + "partner":"4h8m" }, "struct_max_sim_natural":[ @@ -55533,86 +55607,86 @@ ], "subtitle":"Crystal structure of a 6-helix coiled coil cc-hex-h24", "tags":[ - "hydrophobic channel", - "kih interactions", "synthetic biology", + "kih interactions", "de novo protein", + "hydrophobic channel", "coiled coil domain", "hexamer" ], "keywords":[ - "layer", - "accepting", - "running", - "chains", - "one", - "proteins", - "represents", - "unique", - "de", - "novo", - "success", - "although", - "combined", - "challenge", - "stable", - "scaffolds", - "acid", - "formidable", - "area", - "channel", + "leucine", "permeable", + "form", + "aspartic", + "engineering", "lined", + "design", + "heterohexamer", "organization", + "hydrophobic", + "one", + "accepting", + "exclusively", + "histidine", "moreover", - "would", - "residues", - "functions", - "provide", - "subdivision", - "repertoire", - "parallel", - "crystal", - "leucine", + "running", + "structures", + "de", + "lumen", + "natural", + "biology", + "represents", "3", - "engineering", + "side", + "area", + "residues", + "structure", + "synthetic", + "within", + "scaffolds", + "acid", + "leads", "polar", - "bundle", - "heterohexamer", - "design", + "new", + "although", + "provide", + "isoleucine", + "functions", + "layer", + "protein", + "formidable", "mutable", + "understanding", + "subdivision", + "combined", + "basis", + "proteins", + "would", + "mutants", "characterization", - "lumen", - "exclusively", - "structures", - "protein", - "synthetic", + "success", + "novo", + "parallel", + "sequence", + "repertoire", "expand", - "isoleucine", + "forms", + "channel", + "solvent", "present", - "hydrophobic", - "basis", - "natural", + "crystal", + "stable", "describe", - "structure", - "water", - "sequence", "exploited", - "biology", - "understanding", - "increase", + "chains", + "challenge", + "unique", + "bundle", "could", - "within", - "histidine", - "aspartic", - "leads", - "mutants", - "form", - "side", + "increase", "biotechnology", - "solvent", - "forms", - "new" + "water" ], "release_date":"2011-11-16", "publication":"\"A de novo peptide hexamer with a mutable channel\", Nat.Chem.Biol., 7, 935-941", @@ -55649,22 +55723,6 @@ ], "struct_thr_sim_designed":[ - { - "sim":1.0, - "partner":"4h8m" - }, - { - "sim":0.9968000054, - "partner":"6q5k" - }, - { - "sim":0.9970999956, - "partner":"6q5h" - }, - { - "sim":0.9954000115, - "partner":"6q5i" - }, { "sim":0.9987000227, "partner":"3r48" @@ -55675,76 +55733,60 @@ }, { "sim":1.0, - "partner":"3r46" + "partner":"4h8m" }, { "sim":1.0, - "partner":"6q5j" + "partner":"3r46" }, { "sim":1.0, - "partner":"4h7r" + "partner":"4h8g" }, { "sim":1.0, - "partner":"3r3k" + "partner":"6q5j" }, { - "sim":1.0, - "partner":"6q5p" + "sim":0.9970999956, + "partner":"6q5h" }, { "sim":1.0, - "partner":"4h8g" + "partner":"3r3k" }, { "sim":1.0, - "partner":"6q5s" - }, - { - "sim":0.9520000219, - "partner":"4h8l" + "partner":"6q5p" }, { "sim":1.0, - "partner":"4h8f" + "partner":"4h7r" }, { "sim":1.0, - "partner":"3r4a" - }, - { - "sim":0.9987000227, - "partner":"4h8o" + "partner":"6q5s" }, { "sim":1.0, - "partner":"6q5r" - }, - { - "sim":0.9954000115, - "partner":"3r4h" - }, - { - "sim":0.9990000129, - "partner":"4dzl" + "partner":"8a3g" }, { "sim":1.0, - "partner":"4dzk" - }, - { - "sim":0.9649000168, - "partner":"6q5o" + "partner":"6q5r" }, { "sim":1.0, - "partner":"8a3g" + "partner":"4h8f" }, { "sim":0.9965000153, "partner":"8qac" }, + { + "sim":0.9987000227, + "partner":"4h8o" + }, { "sim":0.9768000245, "partner":"6q5q" @@ -55753,6 +55795,14 @@ "sim":0.9545999765, "partner":"5eon" }, + { + "sim":1.0, + "partner":"3r4a" + }, + { + "sim":0.9954000115, + "partner":"3r4h" + }, { "sim":1.0, "partner":"8qab" @@ -55769,13 +55819,37 @@ "sim":1.0, "partner":"8qaa" }, + { + "sim":1.0, + "partner":"4dzk" + }, { "sim":0.9893000126, "partner":"6i1j" }, + { + "sim":0.9990000129, + "partner":"4dzl" + }, { "sim":0.9559999704, "partner":"6yb0" + }, + { + "sim":0.9968000054, + "partner":"6q5k" + }, + { + "sim":0.9954000115, + "partner":"6q5i" + }, + { + "sim":0.9520000219, + "partner":"4h8l" + }, + { + "sim":0.9649000168, + "partner":"6q5o" } ], "struct_thr_sim_natural":[ @@ -55789,7 +55863,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"4h8m" + "partner":"6q5n" }, "struct_max_sim_natural":[ @@ -55876,86 +55950,86 @@ ], "subtitle":"Crystal structure of a hetero-hexamer coiled coil", "tags":[ - "hydrophobic channel", - "kih interactions", "synthetic biology", + "kih interactions", "de novo protein", + "hydrophobic channel", "coiled coil domain", "hexamer" ], "keywords":[ - "layer", - "accepting", - "running", - "chains", - "one", - "proteins", - "represents", - "unique", - "de", - "novo", - "success", - "although", - "combined", - "challenge", - "stable", - "scaffolds", - "acid", - "formidable", - "area", - "channel", + "leucine", "permeable", + "form", + "aspartic", + "engineering", "lined", + "design", + "heterohexamer", "organization", + "hydrophobic", + "one", + "accepting", + "exclusively", + "histidine", "moreover", - "would", - "residues", - "functions", - "provide", - "subdivision", - "repertoire", - "parallel", - "crystal", - "leucine", + "running", + "structures", + "de", + "lumen", + "natural", + "biology", + "represents", "3", - "engineering", + "side", + "area", + "residues", + "structure", + "synthetic", + "within", + "scaffolds", + "acid", + "leads", "polar", - "bundle", - "heterohexamer", - "design", + "new", + "although", + "provide", + "isoleucine", + "functions", + "layer", + "protein", + "formidable", "mutable", + "understanding", + "subdivision", + "combined", + "basis", + "proteins", + "would", + "mutants", "characterization", - "lumen", - "exclusively", - "structures", - "protein", - "synthetic", + "success", + "novo", + "parallel", + "sequence", + "repertoire", "expand", - "isoleucine", + "forms", + "channel", + "solvent", "present", - "hydrophobic", - "basis", - "natural", + "crystal", + "stable", "describe", - "structure", - "water", - "sequence", "exploited", - "biology", - "understanding", - "increase", + "chains", + "challenge", + "unique", + "bundle", "could", - "within", - "histidine", - "aspartic", - "leads", - "mutants", - "form", - "side", + "increase", "biotechnology", - "solvent", - "forms", - "new" + "water" ], "release_date":"2011-11-16", "publication":"\"A de novo peptide hexamer with a mutable channel\", Nat.Chem.Biol., 7, 935-941", @@ -56008,17 +56082,13 @@ "sim":1.0, "partner":"6q5n" }, - { - "sim":1.0, - "partner":"4h8m" - }, { "sim":1.0, "partner":"6q5j" }, { "sim":1.0, - "partner":"6q5p" + "partner":"4h8m" }, { "sim":1.0, @@ -56026,16 +56096,20 @@ }, { "sim":1.0, - "partner":"6q5s" + "partner":"6q5p" }, { "sim":1.0, - "partner":"4h7r" + "partner":"6q5s" }, { "sim":0.9792000055, "partner":"6q5o" }, + { + "sim":1.0, + "partner":"4h7r" + }, { "sim":1.0, "partner":"4h8f" @@ -56064,14 +56138,14 @@ "sim":0.9763000011, "partner":"6q5q" }, - { - "sim":0.9542999864, - "partner":"5eoj" - }, { "sim":0.9575999975, "partner":"5eon" }, + { + "sim":0.9557999969, + "partner":"5vte" + }, { "sim":1.0, "partner":"8qaa" @@ -56096,18 +56170,6 @@ "sim":0.99150002, "partner":"6i1j" }, - { - "sim":0.9557999969, - "partner":"5vte" - }, - { - "sim":0.9725000262, - "partner":"4dzn" - }, - { - "sim":0.9649000168, - "partner":"4dzm" - }, { "sim":0.9728999734, "partner":"4dzk" @@ -56119,6 +56181,18 @@ { "sim":0.9714000225, "partner":"5kb1" + }, + { + "sim":0.9725000262, + "partner":"4dzn" + }, + { + "sim":0.9649000168, + "partner":"4dzm" + }, + { + "sim":0.9542999864, + "partner":"5eoj" } ], "struct_thr_sim_natural":[ @@ -56211,85 +56285,85 @@ ], "subtitle":"Crystal structure of the 4-helix coiled coil cc-tet", "tags":[ - "kih interactions", - "tetramer", "synthetic biology", + "tetramer", + "kih interactions", "de novo protein", "coiled coil domain" ], "keywords":[ - "layer", - "accepting", - "running", - "chains", - "one", - "proteins", - "represents", - "unique", - "de", - "novo", - "success", - "although", - "combined", - "challenge", - "stable", - "scaffolds", - "acid", - "formidable", - "area", - "channel", + "leucine", "permeable", + "form", + "aspartic", + "engineering", "lined", + "design", + "heterohexamer", "organization", + "hydrophobic", + "one", + "accepting", + "exclusively", + "histidine", "moreover", - "would", - "residues", - "functions", - "provide", - "subdivision", - "repertoire", - "parallel", - "crystal", - "leucine", + "running", + "structures", + "de", + "lumen", + "natural", + "biology", + "represents", "3", - "engineering", + "side", + "area", + "residues", + "structure", + "synthetic", + "within", + "scaffolds", + "acid", + "leads", "polar", - "bundle", - "heterohexamer", - "design", + "new", + "although", + "provide", + "isoleucine", + "functions", + "layer", + "protein", + "formidable", "mutable", + "understanding", + "subdivision", + "combined", + "basis", + "proteins", + "would", + "mutants", "characterization", - "lumen", - "exclusively", - "structures", - "protein", - "synthetic", + "success", + "novo", + "parallel", + "sequence", + "repertoire", "expand", - "isoleucine", + "forms", + "channel", + "solvent", "present", - "hydrophobic", - "basis", - "natural", + "crystal", + "stable", "describe", - "structure", - "water", - "sequence", "exploited", - "biology", - "understanding", - "increase", + "chains", + "challenge", + "unique", + "bundle", "could", - "within", - "histidine", - "aspartic", - "leads", - "mutants", - "form", - "side", + "increase", "biotechnology", - "solvent", - "forms", - "new" + "water" ], "release_date":"2011-11-16", "publication":"\"A de novo peptide hexamer with a mutable channel\", Nat.Chem.Biol., 7, 935-941", @@ -56335,13 +56409,21 @@ "partner":"6q5n" }, { - "sim":0.9966999888, - "partner":"6q5j" + "sim":0.989199996, + "partner":"3r47" }, { "sim":0.996900022, "partner":"3r3k" }, + { + "sim":0.9803000093, + "partner":"4dzk" + }, + { + "sim":1.0, + "partner":"3r48" + }, { "sim":0.9983999729, "partner":"3r46" @@ -56350,21 +56432,33 @@ "sim":0.9983000159, "partner":"4h8m" }, + { + "sim":0.9966999888, + "partner":"6q5j" + }, { "sim":1.0, - "partner":"3r48" + "partner":"4dzl" }, { "sim":0.9926000237, "partner":"6i1j" }, { - "sim":1.0, - "partner":"4dzl" + "sim":0.9761999846, + "partner":"5eon" }, { - "sim":1.0, - "partner":"6q5p" + "sim":0.9778000116, + "partner":"8qac" + }, + { + "sim":0.9685000181, + "partner":"5eoj" + }, + { + "sim":0.9667000175, + "partner":"5vte" }, { "sim":0.9983999729, @@ -56375,37 +56469,33 @@ "partner":"6q5q" }, { - "sim":0.9743999839, - "partner":"6q5o" + "sim":1.0, + "partner":"6q5p" + }, + { + "sim":0.9951999784, + "partner":"7qdk" }, { "sim":0.9983999729, "partner":"4h7r" }, { - "sim":1.0, - "partner":"6q5s" + "sim":0.9743999839, + "partner":"6q5o" }, { - "sim":0.9951999784, - "partner":"7qdk" + "sim":1.0, + "partner":"6q5s" }, { "sim":0.9937999845, "partner":"8a3g" }, - { - "sim":0.9803000093, - "partner":"4dzk" - }, { "sim":0.9970999956, "partner":"4h8f" }, - { - "sim":0.9761999846, - "partner":"5eon" - }, { "sim":1.0, "partner":"6q5r" @@ -56422,10 +56512,6 @@ "sim":0.9983000159, "partner":"4dzn" }, - { - "sim":0.9667000175, - "partner":"5vte" - }, { "sim":1.0, "partner":"4h8g" @@ -56434,18 +56520,6 @@ "sim":0.9983999729, "partner":"6g68" }, - { - "sim":0.9778000116, - "partner":"8qac" - }, - { - "sim":0.989199996, - "partner":"3r47" - }, - { - "sim":0.9685000181, - "partner":"5eoj" - }, { "sim":0.9624000192, "partner":"6q5k" @@ -56553,85 +56627,85 @@ ], "subtitle":"Crystal structure of the 4-helix coiled coil cc-tet-phi22", "tags":[ - "kih interactions", - "tetramer", "synthetic biology", + "tetramer", + "kih interactions", "de novo protein", "coiled coil domain" ], "keywords":[ - "layer", - "accepting", - "running", - "chains", - "one", - "proteins", - "represents", - "unique", - "de", - "novo", - "success", - "although", - "combined", - "challenge", - "stable", - "scaffolds", - "acid", - "formidable", - "area", - "channel", + "leucine", "permeable", + "form", + "aspartic", + "engineering", "lined", + "design", + "heterohexamer", "organization", + "hydrophobic", + "one", + "accepting", + "exclusively", + "histidine", "moreover", - "would", + "running", + "structures", + "de", + "lumen", + "natural", + "biology", + "represents", + "3", + "side", + "area", "residues", - "functions", + "structure", + "synthetic", + "within", + "scaffolds", + "acid", + "leads", + "polar", + "new", + "although", "provide", + "isoleucine", + "functions", + "layer", + "protein", + "formidable", + "mutable", + "understanding", "subdivision", - "repertoire", - "parallel", - "crystal", - "leucine", - "3", - "engineering", - "polar", - "bundle", - "heterohexamer", - "design", - "mutable", + "combined", + "basis", + "proteins", + "would", + "mutants", "characterization", - "lumen", - "exclusively", - "structures", - "protein", - "synthetic", + "success", + "novo", + "parallel", + "sequence", + "repertoire", "expand", - "isoleucine", + "forms", + "channel", + "solvent", "present", - "hydrophobic", - "basis", - "natural", + "crystal", + "stable", "describe", - "structure", - "water", - "sequence", "exploited", - "biology", - "understanding", - "increase", + "chains", + "challenge", + "unique", + "bundle", "could", - "within", - "histidine", - "aspartic", - "leads", - "mutants", - "form", - "side", + "increase", "biotechnology", - "solvent", - "forms", - "new" + "water" ], "release_date":"2011-11-16", "publication":"\"A de novo peptide hexamer with a mutable channel\", Nat.Chem.Biol., 7, 935-941", @@ -56672,22 +56746,10 @@ "sim":0.9984999895, "partner":"3r4a" }, - { - "sim":0.9947000146, - "partner":"6q5n" - }, { "sim":0.9962999821, "partner":"3r3k" }, - { - "sim":0.9986000061, - "partner":"3r47" - }, - { - "sim":0.9981999993, - "partner":"3r48" - }, { "sim":1.0, "partner":"4dzl" @@ -56705,52 +56767,76 @@ "partner":"6q5j" }, { - "sim":0.9962999821, - "partner":"6q5h" + "sim":0.9981999993, + "partner":"4h8o" }, { - "sim":0.9947000146, - "partner":"4dzk" + "sim":1.0, + "partner":"6q5p" }, { - "sim":0.9923999906, - "partner":"6i1j" + "sim":0.9981999993, + "partner":"4h7r" }, { - "sim":0.9981999993, - "partner":"4h8o" + "sim":0.9955999851, + "partner":"6q5s" }, { - "sim":0.9962999821, - "partner":"4h8f" + "sim":0.9900000095, + "partner":"4dzn" }, { - "sim":0.9886000156, - "partner":"7qdk" + "sim":0.9918000102, + "partner":"4h8g" }, { - "sim":0.9635999799, - "partner":"6g6a" + "sim":0.9872000217, + "partner":"6g68" }, { - "sim":0.9844999909, - "partner":"8qac" + "sim":0.9538000226, + "partner":"8qaa" }, { - "sim":1.0, - "partner":"6q5p" + "sim":0.9986000061, + "partner":"3r47" + }, + { + "sim":0.9857000113, + "partner":"6q5k" + }, + { + "sim":0.9947000146, + "partner":"6q5n" + }, + { + "sim":0.9962999821, + "partner":"6q5h" + }, + { + "sim":0.9904999733, + "partner":"6q5i" }, { "sim":0.9981999993, - "partner":"4h7r" + "partner":"3r48" }, { - "sim":0.9659000039, - "partner":"6q5q" + "sim":0.9962999821, + "partner":"4h8f" }, { - "sim":0.9883999825, - "partner":"8a3g" + "sim":0.9923999906, + "partner":"6i1j" + }, + { + "sim":0.9886000156, + "partner":"7qdk" + }, + { + "sim":0.9947000146, + "partner":"4dzk" }, { "sim":0.9929000139, @@ -56758,28 +56844,20 @@ }, { "sim":0.9659000039, - "partner":"6q5o" - }, - { - "sim":0.9955999851, - "partner":"6q5s" + "partner":"6q5q" }, { - "sim":0.9900000095, - "partner":"4dzn" + "sim":0.9659000039, + "partner":"6q5o" }, { - "sim":0.9918000102, - "partner":"4h8g" + "sim":0.9883999825, + "partner":"8a3g" }, { "sim":0.9531000257, "partner":"5vte" }, - { - "sim":0.9872000217, - "partner":"6g68" - }, { "sim":0.9955999851, "partner":"6q5r" @@ -56789,16 +56867,12 @@ "partner":"5eon" }, { - "sim":0.9857000113, - "partner":"6q5k" - }, - { - "sim":0.9904999733, - "partner":"6q5i" + "sim":0.9635999799, + "partner":"6g6a" }, { - "sim":0.9538000226, - "partner":"8qaa" + "sim":0.9844999909, + "partner":"8qac" } ], "struct_thr_sim_natural":[ @@ -56891,137 +56965,137 @@ ], "subtitle":"Crystal structure of a section of a de novo design gigadalton protein fibre", "tags":[ - "kih interactions", "synthetic biology", - "fiber", - "helical reconstruction", + "kih interactions", "de novo protein", - "coiled coil domain" + "coiled coil domain", + "fiber", + "helical reconstruction" ], "keywords":[ - "interpretation", - "analysis", - "nm", - "bridge", - "long", - "map", - "peptide", - "prolonged", - "designed", - "programmed", - "provide", - "dimeric", - "crystal", - "determined", - "potential", + "gigadalton", + "engineering", + "individual", + "cryotransmission", + "structural", + "resolution", "show", - "basis", - "8", - "nanometer", "therefore", - "structure", - "allowed", - "pack", - "ultrastructure", - "building", - "nanotechnology", - "direct", - "coiled", - "simulation", - "proteins", - "larger", - "presents", - "unique", - "de", - "\u00e5", + "micrographs", + "side", + "comprise", + "within", + "description", + "new", + "bridge", + "\u03bcm", + "model", + "various", + "insight", + "protein", + "prolonged", + "electron", + "clear", + "microscopy", + "novo", "manner", + "systems", + "two", + "applications", + "crystal", + "stable", + "chains", + "using", + "material", + "construction", + "supramolecular", + "interpretation", + "controlled", + "taken", + "confirming", + "safs", + "viability", "medicine", - "resulting", - "small", - "nature", - "difficulties", - "biomaterials", "furthermore", - "assemble", "particularly", - "fiber", - "forming", - "individual", - "structures", - "material", + "level", + "nanotechnology", + "address", "derived", - "natural", - "complexity", + "basis", + "proteins", + "packing", + "small", + "larger", + "density", + "biomaterials", + "regimes", + "unprecedented", "future", - "give", - "coil", - "form", - "compared", - "systems", - "data", - "taken", - "assemblies", - "resolution", - "micrographs", "incapable", - "address", - "description", - "biomimetic", - "engineering", - "cryotransmission", - "clear", - "provides", + "studying", + "long", + "millions", + "peptide", + "forming", + "direct", "design", - "model", + "compared", + "provides", + "fiber", + "natural", + "potential", + "nm", + "approximately", + "difficulties", + "complexity", + "simulation", + "wide", + "ultrastructure", "reduced", + "fibrils", + "validated", + "map", + "building", + "system", "considerably", - "using", - "applications", - "confirming", - "routes", - "describe", - "techniques", - "safs", - "comprise", - "packing", - "structural", - "millions", + "peptides", "3d", - "supramolecular", - "density", - "chains", - "gigadalton", - "construction", + "techniques", + "describe", + "unique", + "assemblies", + "designed", + "form", + "analysis", "fibers", - "novo", - "wide", - "stable", - "unprecedented", - "\u03bcm", - "fibrils", - "insight", - "peptides", - "electron", - "controlled", - "two", - "approximately", - "studying", - "system", - "validated", - "viability", - "protein", - "microscopy", + "pack", + "presents", + "inspiration", + "structures", + "de", "tens", - "block", + "allowed", "micrometer", - "various", + "\u00e5", + "structure", + "provide", + "determined", + "resulting", + "block", + "give", + "nature", + "biomimetic", "understanding", - "within", - "regimes", - "side", - "inspiration", - "level", - "new" + "programmed", + "routes", + "coiled", + "coil", + "nanometer", + "data", + "assemble", + "8", + "dimeric" ], "release_date":"2012-08-08", "publication":"\"Cryo-transmission electron microscopy structure of a gigadalton peptide fiber of de novo design\", Proc.Natl.Acad.Sci.USA, 109, 13266-13271", @@ -57145,69 +57219,69 @@ "interacts with single walled nanotube (swnt)" ], "keywords":[ - "series", - "general", - "swnt", - "geometrically", - "textured", - "created", - "molecular", + "surface", "surrounding", - "tubular", - "gold", - "superstructures", - "organize", - "assemblies", - "approach", - "carbon", + "engineering", + "need", + "molecular", + "richly", + "symmetry", + "design", + "recognition", "defined", - "coating", - "whereby", + "carbon", + "order", + "organize", + "targeted", "nanoparticles", - "along", "swnts", "define", + "steps", + "assembly", "properties", - "peptides", + "specific", + "structure", + "converts", + "nanotubes", + "superstructures", + "functionalization", + "surfaces", + "whereby", + "interactions", + "exemplified", + "axis", + "superstructure", + "approach", "proceeds", + "coating", + "helical", + "packing", + "capable", + "molecules", + "gold", + "swnt", + "series", + "smooth", + "general", + "textured", + "tubular", "directing", - "surfaces", + "arrays", + "sequence", "highly", + "peptides", + "favorable", "intersubunit", - "capable", - "targeted", - "recognition", - "specific", - "superstructure", - "engineering", - "richly", - "assemble", - "smooth", - "design", "encode", + "created", + "geometrically", + "along", "procedure", - "order", - "helical", - "converts", - "interactions", - "arrays", - "nanotubes", - "surface", "describe", - "symmetry", - "structure", - "sequence", - "assembly", - "computational", - "favorable", - "axis", - "functionalization", - "exemplified", - "molecules", - "steps", - "packing", + "assemble", + "assemblies", "create", - "need", + "computational", "multilayered" ], "release_date":"2011-06-15", @@ -57271,7 +57345,7 @@ ], "seq_max_sim_designed":{ "sim":49.0, - "partner":"5hkn" + "partner":"5hkr" }, "seq_max_sim_natural":[ @@ -57327,104 +57401,104 @@ ], "subtitle":"Crystal structure of a kge collagen mimetic peptide at 1.68 a", "tags":[ - "triple helix", "collagen mimetic peptide", + "triple helix", "biosynthetic protein" ], "keywords":[ - "work", - "stabilizing", + "negatively", + "role", + "collagen", "densely", - "crystallography", - "allowing", - "abundant", - "triple", - "find", - "interactions", + "side", + "differences", + "folding", + "dual", + "protein", + "study", + "helical", + "little", + "stabilization", + "charged", + "axial", + "resonance", + "two", + "nuclear", + "isolated", + "helices", + "adjacent", + "similarities", + "using", + "play", "conformation", - "packed", - "structure", + "deceptively", "however", - "rearrangement", + "lysine", + "positively", + "stabilizing", + "overall", + "aspartate", + "helix", "crucial", + "family", + "rearrangement", + "level", + "magnetic", "contacts", - "isolated", - "lysine", - "fibril", - "chain", + "stability", "proteins", - "play", + "packing", "process", - "similarities", - "family", - "negatively", + "may", "registration", - "positively", + "lateral", + "fibril", + "triple", + "allowing", + "combination", + "simpler", + "energy", + "packed", + "work", + "spectroscopy", + "chain", "suggests", "simple", - "simpler", - "little", - "nuclear", - "collagen", - "structures", - "aspartate", - "charged", - "solution", - "resonance", + "fibrillization", "assembly", - "first", - "role", - "second", - "stability", + "fold", + "humans", + "carry", "amino", - "detailed", - "lateral", - "acids", - "may", - "landscape", - "observed", - "helical", - "using", - "nmr", - "energy", + "solution", "formation", - "packing", - "important", - "fibrillization", - "stabilization", - "overall", - "despite", - "magnetic", - "helices", + "understood", + "types", + "landscape", + "whereas", + "reveal", + "crystalline", "fibers", - "study", "collagens", - "axial", - "fold", - "carry", - "humans", - "spectroscopy", - "reveal", - "understood", - "adjacent", - "two", - "glutamate", - "deceptively", + "observed", + "structures", + "first", + "detailed", + "structure", + "important", + "crystallography", + "nmr", + "interactions", "state", - "significant", - "protein", - "dual", - "helix", - "differences", - "types", - "combination", - "distinct", "understanding", - "crystalline", - "side", - "folding", - "level", - "whereas" + "find", + "abundant", + "distinct", + "acids", + "glutamate", + "despite", + "second", + "significant" ], "release_date":"2011-12-28", "publication":"\"Structural insights into charge pair interactions in triple helical collagen-like proteins\", J.Biol.Chem., 287, 8039-8047", @@ -57538,88 +57612,88 @@ ], "subtitle":"Computationally designed tim-barrel protein, halfflr", "tags":[ - "symmetric superfold", "de novo protein", + "symmetric superfold", "tim-barrel" ], "keywords":[ - "imidazole", - "monomeric", - "gene", + "demonstrates", + "half", + "explains", + "elements", + "new", + "exhibits", "strategy", - "synthase", - "crystallography", - "proposed", - "smaller", - "evolve", + "flr", + "protein", + "readily", + "topologies", + "energetically", + "domains", + "underwent", + "secondary", "\u03b2\u03b1", + "attractive", + "imidazole", + "corresponding", + "dimerizes", + "construction", + "perfectly", + "phosphate", + "soluble", + "computationally", + "gene", + "termed", + "stability", + "proteins", "cut", - "software", - "8", - "structure", + "adopts", "favored", - "computationally", + "pieces", + "homodimer", + "larger", + "evolve", "duplication", + "computational", + "abundance", + "symmetry", + "design", + "atomic", "principles", - "flr", - "proteins", - "detail", - "larger", - "presents", - "elements", + "fusion", "used", - "demonstrates", - "underwent", + "rosetta", + "variant", + "also", + "successful", "symmetric", - "nature", - "glycerol", - "perfectly", - "dimerizes", - "corresponding", - "atomic", - "pieces", - "fusion", - "form", - "previously", - "verified", - "stability", + "underlying", + "sequence", "demonstrated", + "arrangement", "superfolds", - "exhibits", - "topologies", + "synthase", + "proposed", "engineer", - "successful", - "design", - "energetically", - "soluble", - "secondary", - "progress", - "symmetry", - "underlying", - "sequence", - "variant", + "form", + "verified", "superfold", - "arrangement", - "construction", + "presents", + "progress", + "previously", + "structure", + "monomeric", + "glycerol", + "crystallography", + "nature", "homodimeric", - "also", - "termed", - "attractive", - "explains", - "rosetta", - "half", - "phosphate", - "abundance", - "domains", - "protein", - "homodimers", - "adopts", - "readily", - "homodimer", "understanding", - "computational", + "homodimers", "silico", - "new" + "detail", + "software", + "smaller", + "8" ], "release_date":"2011-11-16", "publication":"\"Exploring symmetry as an avenue to the computational design of large protein domains\", J.Am.Chem.Soc., 133, 18026-18029", @@ -57660,11 +57734,11 @@ }, { "sim":183.0, - "partner":"5d2v" + "partner":"5d2t" }, { "sim":183.0, - "partner":"5d2t" + "partner":"5d2v" }, { "sim":183.0, @@ -57676,11 +57750,11 @@ }, { "sim":178.0, - "partner":"5d2x" + "partner":"5d2y" }, { "sim":178.0, - "partner":"5d2y" + "partner":"5d2x" }, { "sim":175.0, @@ -57762,11 +57836,11 @@ }, { "sim":74.0, - "partner":"1jvn" + "partner":"1ox5" }, { "sim":74.0, - "partner":"1ox5" + "partner":"1jvn" }, { "sim":74.0, @@ -57855,88 +57929,88 @@ ], "subtitle":"Computationally designed two-fold symmetric tim-barrel protein, flr", "tags":[ - "symmetric superfold", "de novo protein", + "symmetric superfold", "tim-barrel" ], "keywords":[ - "imidazole", - "monomeric", - "gene", + "demonstrates", + "half", + "explains", + "elements", + "new", + "exhibits", "strategy", - "synthase", - "crystallography", - "proposed", - "smaller", - "evolve", + "flr", + "protein", + "readily", + "topologies", + "energetically", + "domains", + "underwent", + "secondary", "\u03b2\u03b1", + "attractive", + "imidazole", + "corresponding", + "dimerizes", + "construction", + "perfectly", + "phosphate", + "soluble", + "computationally", + "gene", + "termed", + "stability", + "proteins", "cut", - "software", - "8", - "structure", + "adopts", "favored", - "computationally", + "pieces", + "homodimer", + "larger", + "evolve", "duplication", + "computational", + "abundance", + "symmetry", + "design", + "atomic", "principles", - "flr", - "proteins", - "detail", - "larger", - "presents", - "elements", + "fusion", "used", - "demonstrates", - "underwent", + "rosetta", + "variant", + "also", + "successful", "symmetric", - "nature", - "glycerol", - "perfectly", - "dimerizes", - "corresponding", - "atomic", - "pieces", - "fusion", - "form", - "previously", - "verified", - "stability", + "underlying", + "sequence", "demonstrated", + "arrangement", "superfolds", - "exhibits", - "topologies", + "synthase", + "proposed", "engineer", - "successful", - "design", - "energetically", - "soluble", - "secondary", - "progress", - "symmetry", - "underlying", - "sequence", - "variant", + "form", + "verified", "superfold", - "arrangement", - "construction", + "presents", + "progress", + "previously", + "structure", + "monomeric", + "glycerol", + "crystallography", + "nature", "homodimeric", - "also", - "termed", - "attractive", - "explains", - "rosetta", - "half", - "phosphate", - "abundance", - "domains", - "protein", - "homodimers", - "adopts", - "readily", - "homodimer", "understanding", - "computational", + "homodimers", "silico", - "new" + "detail", + "software", + "smaller", + "8" ], "release_date":"2011-11-16", "publication":"\"Exploring symmetry as an avenue to the computational design of large protein domains\", J.Am.Chem.Soc., 133, 18026-18029", @@ -57977,11 +58051,11 @@ }, { "sim":244.0, - "partner":"5d2v" + "partner":"5d2t" }, { "sim":244.0, - "partner":"5d2t" + "partner":"5d2v" }, { "sim":244.0, @@ -57993,11 +58067,11 @@ }, { "sim":239.0, - "partner":"5d2x" + "partner":"5d2y" }, { "sim":239.0, - "partner":"5d2y" + "partner":"5d2x" }, { "sim":237.0, @@ -58079,11 +58153,11 @@ }, { "sim":91.0, - "partner":"1jvn" + "partner":"1ox5" }, { "sim":91.0, - "partner":"1ox5" + "partner":"1jvn" }, { "sim":91.0, @@ -58176,76 +58250,76 @@ ], "subtitle":"Merohedral twinning in protein crystals revealed a new synthetic three helix bundle motif", "tags":[ - "de novo protein", - "parallel three helix bundle" + "parallel three helix bundle", + "de novo protein" ], "keywords":[ - "coiled", + "made", "analysis", - "reported", - "inject", - "characteristics", - "delivery", + "occupy", + "design", + "regularity", + "compared", "topology", - "middle", - "qflmlmf", - "propensity", - "separated", - "amino", - "reveals", - "heptad", - "viral", - "proteins", - "genetic", - "use", - "needles", - "host", + "number", + "key", + "simplicity", + "therapeutics", "de", - "novo", "single", - "occupy", - "four", - "attractive", - "acid", - "drug", - "peptide", "determination", - "number", + "vaccines", + "furthermore", "presence", "heptads", - "tail", + "three", + "structure", + "synthetic", + "acid", + "canonical", "specific", + "specialized", + "host", + "delivery", + "middle", + "inject", + "amino", + "propensity", + "drug", + "proteins", + "molecules", + "viral", + "use", + "coiled", + "qflmlmf", + "novo", "contains", - "canonical", - "crystal", + "cells", "parallel", - "system", - "geometric", - "ke1", - "furthermore", - "made", - "design", + "sequence", + "coil", + "reported", + "reveals", + "genetic", "arrangement", + "system", + "systems", + "tail", "position", - "synthetic", - "therapeutics", - "material", "present", + "crystal", + "separated", "coils", - "structure", - "three", - "sequence", - "specialized", - "coil", - "key", - "vaccines", - "regularity", - "compared", - "cells", - "simplicity", - "molecules", "stranded", - "systems" + "four", + "attractive", + "ke1", + "characteristics", + "needles", + "peptide", + "material", + "heptad", + "geometric" ], "release_date":"2012-09-26", "publication":"\"Analysis of the crystal structure of a parallel three-stranded coiled coil\", Proteins, 91, 1254-1260", @@ -58347,94 +58421,94 @@ ], "subtitle":"Crystal structure of the de novo designed peptide alpha4h", "tags":[ - "unknown function", - "alpha helix" + "alpha helix", + "unknown function" ], "keywords":[ + "extensively", + "proved", + "hydrophobic", + "structural", + "fluorinated", + "rationally", + "side", + "three", + "within", + "fluorocarbon", + "exhibits", + "accompany", + "protein", + "match", + "chains", + "using", + "similar", + "either", + "stabilities", + "however", + "seem", + "volume", + "accommodated", + "efforts", "stabilizing", + "effect", "thus", - "increasing", - "explained", + "particularly", + "residues", + "increases", + "specific", + "inform", + "although", + "finding", + "nonfluorinated", "fluorous", - "illustrated", - "stabilities", - "extremely", + "useful", + "address", "basis", - "interactions", - "packed", - "compensating", - "minimal", - "nonfluorinated", - "however", - "increases", - "fluorocarbon", - "replace", + "extremely", + "stability", + "hydrocarbon", + "buried", "proteins", - "larger", - "solved", - "similar", - "although", "modulate", - "area", - "remains", - "small", + "illustrated", + "explained", "highly", - "volume", - "hydrocarbon", - "particularly", - "better", - "match", + "small", + "larger", + "replace", + "surface", "effective", - "structures", - "modifying", - "inform", - "buried", - "proved", - "three", - "function", - "either", + "design", "compared", + "packed", + "compensating", + "absence", "properties", - "stability", - "data", "amino", - "exhibits", - "noncanonical", + "understood", + "solved", + "modifying", + "perturbation", + "increasing", + "minimal", + "counterpart", + "poorly", + "structures", + "area", + "remains", "among", - "acids", "shape", - "finding", - "address", - "useful", "closely", - "perturbation", - "specific", - "design", - "rationally", - "using", - "hydrophobic", - "effect", - "surface", - "extensively", + "noncanonical", + "interactions", + "function", + "acids", + "cores", + "data", "fluorination", - "accompany", - "structural", - "poorly", - "chains", - "observations", - "efforts", - "residues", - "understood", - "absence", "problem", - "counterpart", - "fluorinated", - "seem", - "accommodated", - "cores", - "protein", - "within", - "side" + "better", + "observations" ], "release_date":"2012-03-14", "publication":"\"Structural basis for the enhanced stability of highly fluorinated proteins\", Proc.Natl.Acad.Sci.USA, 109, 4810-4815", @@ -58533,96 +58607,96 @@ ], "subtitle":"Crystal structure of the de novo designed fluorinated peptide alpha4f3a", "tags":[ - "unknown function", - "fluorinated protein", "alpha helix", - "de novo designed" + "de novo designed", + "fluorinated protein", + "unknown function" ], "keywords":[ + "extensively", + "proved", + "hydrophobic", + "structural", + "fluorinated", + "rationally", + "side", + "three", + "within", + "fluorocarbon", + "exhibits", + "accompany", + "protein", + "match", + "chains", + "using", + "similar", + "either", + "stabilities", + "however", + "seem", + "volume", + "accommodated", + "efforts", "stabilizing", + "effect", "thus", - "increasing", - "explained", + "particularly", + "residues", + "increases", + "specific", + "inform", + "although", + "finding", + "nonfluorinated", "fluorous", - "illustrated", - "stabilities", - "extremely", + "useful", + "address", "basis", - "interactions", - "packed", - "compensating", - "minimal", - "nonfluorinated", - "however", - "increases", - "fluorocarbon", - "replace", + "extremely", + "stability", + "hydrocarbon", + "buried", "proteins", - "larger", - "solved", - "similar", - "although", "modulate", - "area", - "remains", - "small", + "illustrated", + "explained", "highly", - "volume", - "hydrocarbon", - "particularly", - "better", - "match", + "small", + "larger", + "replace", + "surface", "effective", - "structures", - "modifying", - "inform", - "buried", - "proved", - "three", - "function", - "either", + "design", "compared", + "packed", + "compensating", + "absence", "properties", - "stability", - "data", "amino", - "exhibits", - "noncanonical", + "understood", + "solved", + "modifying", + "perturbation", + "increasing", + "minimal", + "counterpart", + "poorly", + "structures", + "area", + "remains", "among", - "acids", "shape", - "finding", - "address", - "useful", "closely", - "perturbation", - "specific", - "design", - "rationally", - "using", - "hydrophobic", - "effect", - "surface", - "extensively", + "noncanonical", + "interactions", + "function", + "acids", + "cores", + "data", "fluorination", - "accompany", - "structural", - "poorly", - "chains", - "observations", - "efforts", - "residues", - "understood", - "absence", "problem", - "counterpart", - "fluorinated", - "seem", - "accommodated", - "cores", - "protein", - "within", - "side" + "better", + "observations" ], "release_date":"2012-03-14", "publication":"\"Structural basis for the enhanced stability of highly fluorinated proteins\", Proc.Natl.Acad.Sci.USA, 109, 4810-4815", @@ -58724,96 +58798,96 @@ ], "subtitle":"Crystal structure of the de novo designed fluorinated peptide alpha4f3af3d", "tags":[ - "unknown function", - "fluorinated protein", "alpha helix", - "de novo designed" + "de novo designed", + "fluorinated protein", + "unknown function" ], "keywords":[ + "extensively", + "proved", + "hydrophobic", + "structural", + "fluorinated", + "rationally", + "side", + "three", + "within", + "fluorocarbon", + "exhibits", + "accompany", + "protein", + "match", + "chains", + "using", + "similar", + "either", + "stabilities", + "however", + "seem", + "volume", + "accommodated", + "efforts", "stabilizing", + "effect", "thus", - "increasing", - "explained", + "particularly", + "residues", + "increases", + "specific", + "inform", + "although", + "finding", + "nonfluorinated", "fluorous", - "illustrated", - "stabilities", - "extremely", + "useful", + "address", "basis", - "interactions", - "packed", - "compensating", - "minimal", - "nonfluorinated", - "however", - "increases", - "fluorocarbon", - "replace", + "extremely", + "stability", + "hydrocarbon", + "buried", "proteins", - "larger", - "solved", - "similar", - "although", "modulate", - "area", - "remains", - "small", + "illustrated", + "explained", "highly", - "volume", - "hydrocarbon", - "particularly", - "better", - "match", + "small", + "larger", + "replace", + "surface", "effective", - "structures", - "modifying", - "inform", - "buried", - "proved", - "three", - "function", - "either", + "design", "compared", + "packed", + "compensating", + "absence", "properties", - "stability", - "data", "amino", - "exhibits", - "noncanonical", + "understood", + "solved", + "modifying", + "perturbation", + "increasing", + "minimal", + "counterpart", + "poorly", + "structures", + "area", + "remains", "among", - "acids", "shape", - "finding", - "address", - "useful", "closely", - "perturbation", - "specific", - "design", - "rationally", - "using", - "hydrophobic", - "effect", - "surface", - "extensively", + "noncanonical", + "interactions", + "function", + "acids", + "cores", + "data", "fluorination", - "accompany", - "structural", - "poorly", - "chains", - "observations", - "efforts", - "residues", - "understood", - "absence", "problem", - "counterpart", - "fluorinated", - "seem", - "accommodated", - "cores", - "protein", - "within", - "side" + "better", + "observations" ], "release_date":"2012-03-14", "publication":"\"Structural basis for the enhanced stability of highly fluorinated proteins\", Proc.Natl.Acad.Sci.USA, 109, 4810-4815", @@ -58941,91 +59015,91 @@ "subtitle":"Crystal structure of an enzyme redesigned through multiplayer online gaming: ce6", "tags":[ "foldit", - "beta-propeller", - "computer-aided design", - "substrate specificity", - "crowdsourcing", "active site redesign", - "hydrolase", - "diels-alder", - "multiplayer online gaming", "enzyme design", - "protein engineering", "de novo protein", + "crowdsourcing", + "diels-alder", + "hydrolase", + "multiplayer online gaming", "helix-loop-helix", + "protein engineering", "de novo protein, hydrolase", + "beta-propeller", + "computer-aided design", "loop remodel", + "substrate specificity", "computationally-directed design" ], "keywords":[ - "creativity", - "macroscopic", - "demonstrate", + "designed", "substrates", - "crowdsourcing", - "results", + "life", + "naturally", + "design", + "problems", + "enhance", + "fuels", + "additional", + "iterations", + "reactions", + "renewable", + "production", + "de", + "remodeling", "functional", + "bimolecular", + "everyday", + "computationally", + "structure", "challenges", - "large", - "use", "report", - "de", - "catalysts", - "novo", - "enzymes", - "catalytic", - "remodel", - "drugs", - "encountered", - "problems", + "positioned", + "results", + "beyond", + "insertion", + "model", + "efficiencies", "crystallography", - "human", - "including", + "interactions", + "players", "increased", - "enzyme", - "reactions", - "efficiencies", - "enhance", - "designed", - "enable", - "generated", - "beyond", - "activity", + "large", "motif", - "occurring", + "characterization", + "showed", + "several", "challenged", - "production", "holds", - "design", - "fuels", - "several", - "players", - "online", - "characterization", - "positioned", - "promise", - "naturally", - "interactions", - "model", - "life", - "adopts", + "use", + "enzymes", "backbone", - "renewable", - "insertion", - "structure", + "novo", + "enable", + "activity", + "including", + "adopts", + "demonstrate", + "enzyme", + "chemicals", "foldit", - "bimolecular", - "showed", + "generated", "extend", - "chemicals", - "computationally", + "promise", + "drugs", + "catalytic", + "remodel", + "macroscopic", + "crowdsourcing", + "creativity", + "human", "computational", - "everyday", + "encountered", + "online", + "lower", "game", - "additional", - "remodeling", - "iterations", - "lower" + "catalysts", + "occurring" ], "release_date":"2012-02-01", "publication":"\"Increased Diels-Alderase activity through backbone remodeling guided by Foldit players\", Nat.Biotechnol., 30, 190-192", @@ -59200,115 +59274,115 @@ ], "subtitle":"Three dimensional structure of de novo designed cysteine esterase ech19, northeast structural genomics consortium target or49", "tags":[ + "nesg", "northeast structural genomics consortium", "hydrolase", - "structural genomics", - "protein structure initiative", - "nesg", "psi-biology", - "ech19" + "structural genomics", + "ech19", + "protein structure initiative" ], "keywords":[ - "evolution", - "intermediate", - "independent", - "results", - "contributions", - "must", - "strategy", - "catalysts", - "scaffolds", - "accelerating", - "cat", - "designed", - "programmed", - "dyads", - "triads", - "crystal", + "kinetic", "overcome", - "paired", - "designing", - "computationally", - "minimal", - "achieve", - "catalysis", - "rates", - "general", + "requirements", + "side", "combining", - "k", - "acylated", - "amide", - "challenges", - "exhibited", - "enzymes", - "elements", - "variants", "rapidly", - "nh", - "substrate", - "difficult", - "motif", - "nucleophilic", - "properly", - "highlight", - "efficiency", - "400", - "structures", - "requirements", - "natural", - "cysteines", - "molecules", - "course", - "much", - "esterase", - "obtained", + "elements", + "results", + "strategy", "following", - "bridging", + "motif", "cleavage", - "hydrolysis", + "site", + "general", "subsequent", - "higher", "catalytic", - "holes", - "four", + "k", + "crystal", + "chains", + "oxyanion", + "using", + "water", + "achieve", + "cat", + "bridging", + "formed", + "limits", + "exhibited", + "computationally", + "overall", "ester", - "artificial", + "parse", "optimization", + "paired", + "accelerating", + "sites", + "dyads", + "enzymes", + "success", + "activation", + "acylated", + "found", + "evolution", + "higher", + "four", + "computational", + "rates", + "catalysts", + "obtained", + "emerged", + "slow", + "designing", + "highlight", + "design", + "course", "moreover", - "limits", + "must", "active", - "activity", - "design", - "rather", - "using", - "high", - "indicate", + "natural", + "substrate", + "different", + "amide", + "experiments", "usually", - "kinetic", - "sites", - "designs", - "overall", - "chains", "groups", - "success", - "experiments", - "understand", - "different", - "found", + "independent", "explore", - "levels", - "oxyanion", "backbone", - "water", - "emerged", - "computational", - "activation", - "side", - "parse", - "site", - "slow", - "formed", - "dyad" + "holes", + "levels", + "nh", + "minimal", + "contributions", + "catalysis", + "designed", + "indicate", + "esterase", + "rather", + "variants", + "structures", + "400", + "understand", + "hydrolysis", + "scaffolds", + "challenges", + "properly", + "nucleophilic", + "cysteines", + "intermediate", + "programmed", + "artificial", + "molecules", + "dyad", + "high", + "activity", + "much", + "difficult", + "triads", + "efficiency", + "designs" ], "release_date":"2011-10-26", "publication":"\"Computational design of catalytic dyads and oxyanion holes for ester hydrolysis\", J.Am.Chem.Soc., 134, 16197-16206", @@ -59379,15 +59453,15 @@ }, { "sim":60.0, - "partner":"2z8f" + "partner":"2z8d" }, { "sim":60.0, - "partner":"2z8d" + "partner":"2z8e" }, { "sim":60.0, - "partner":"2z8e" + "partner":"2z8f" }, { "sim":58.0, @@ -59403,11 +59477,11 @@ }, { "sim":51.0, - "partner":"2i58" + "partner":"2hq0" }, { "sim":51.0, - "partner":"2hq0" + "partner":"2i58" }, { "sim":51.0, @@ -59569,117 +59643,117 @@ ], "subtitle":"X-ray structure of de novo design cysteine esterase fr29, northeast structural genomics consortium target or52", "tags":[ - "fr29", - "northeast structural genomics consortium", - "structural genomics", + "de novo design", "protein structure initiative", - "unknown function", "nesg", - "psi-biology", + "northeast structural genomics consortium", + "unknown function", + "structural genomics", + "fr29", "structural genomics, unknown function", - "de novo design" + "psi-biology" ], "keywords":[ - "evolution", - "intermediate", - "independent", - "results", - "contributions", - "must", - "strategy", - "catalysts", - "scaffolds", - "accelerating", - "cat", - "designed", - "programmed", - "dyads", - "triads", - "crystal", + "kinetic", "overcome", - "paired", - "designing", - "computationally", - "minimal", - "achieve", - "catalysis", - "rates", - "general", + "requirements", + "side", "combining", - "k", - "acylated", - "amide", - "challenges", - "exhibited", - "enzymes", - "elements", - "variants", "rapidly", - "nh", - "substrate", - "difficult", - "motif", - "nucleophilic", - "properly", - "highlight", - "efficiency", - "400", - "structures", - "requirements", - "natural", - "cysteines", - "molecules", - "course", - "much", - "esterase", - "obtained", + "elements", + "results", + "strategy", "following", - "bridging", + "motif", "cleavage", - "hydrolysis", + "site", + "general", "subsequent", - "higher", "catalytic", - "holes", - "four", + "k", + "crystal", + "chains", + "oxyanion", + "using", + "water", + "achieve", + "cat", + "bridging", + "formed", + "limits", + "exhibited", + "computationally", + "overall", "ester", - "artificial", + "parse", "optimization", + "paired", + "accelerating", + "sites", + "dyads", + "enzymes", + "success", + "activation", + "acylated", + "found", + "evolution", + "higher", + "four", + "computational", + "rates", + "catalysts", + "obtained", + "emerged", + "slow", + "designing", + "highlight", + "design", + "course", "moreover", - "limits", + "must", "active", - "activity", - "design", - "rather", - "using", - "high", - "indicate", + "natural", + "substrate", + "different", + "amide", + "experiments", "usually", - "kinetic", - "sites", - "designs", - "overall", - "chains", "groups", - "success", - "experiments", - "understand", - "different", - "found", + "independent", "explore", - "levels", - "oxyanion", "backbone", - "water", - "emerged", - "computational", - "activation", - "side", - "parse", - "site", - "slow", - "formed", - "dyad" + "holes", + "levels", + "nh", + "minimal", + "contributions", + "catalysis", + "designed", + "indicate", + "esterase", + "rather", + "variants", + "structures", + "400", + "understand", + "hydrolysis", + "scaffolds", + "challenges", + "properly", + "nucleophilic", + "cysteines", + "intermediate", + "programmed", + "artificial", + "molecules", + "dyad", + "high", + "activity", + "much", + "difficult", + "triads", + "efficiency", + "designs" ], "release_date":"2011-12-07", "publication":"\"Computational design of catalytic dyads and oxyanion holes for ester hydrolysis\", J.Am.Chem.Soc., 134, 16197-16206", @@ -59713,33 +59787,29 @@ ], "seq_thr_sim_natural":[ - { - "sim":607.0, - "partner":"3fhj" - }, { "sim":607.0, "partner":"1mb2" }, { "sim":607.0, - "partner":"1i6k" + "partner":"3fhj" }, { "sim":607.0, - "partner":"1i6l" + "partner":"1mau" }, { "sim":607.0, - "partner":"1i6m" + "partner":"2ov4" }, { "sim":607.0, - "partner":"1mau" + "partner":"1i6k" }, { "sim":607.0, - "partner":"2ov4" + "partner":"1i6l" }, { "sim":607.0, @@ -59749,6 +59819,10 @@ "sim":607.0, "partner":"1maw" }, + { + "sim":607.0, + "partner":"1i6m" + }, { "sim":604.0, "partner":"3fi0" @@ -59817,7 +59891,7 @@ ], "seq_max_sim_natural":{ "sim":607.0, - "partner":"3fhj" + "partner":"1mb2" }, "struct_max_sim_designed":{ "sim":0.386500001, @@ -59871,104 +59945,104 @@ ], "subtitle":"Crystal structure of a kgd collagen mimetic peptide at 2.0 a", "tags":[ - "triple helix", "collagen mimetic peptide", + "triple helix", "biosynthetic protein" ], "keywords":[ - "work", - "stabilizing", + "negatively", + "role", + "collagen", "densely", - "crystallography", - "allowing", - "abundant", - "triple", - "find", - "interactions", + "side", + "differences", + "folding", + "dual", + "protein", + "study", + "helical", + "little", + "stabilization", + "charged", + "axial", + "resonance", + "two", + "nuclear", + "isolated", + "helices", + "adjacent", + "similarities", + "using", + "play", "conformation", - "packed", - "structure", + "deceptively", "however", - "rearrangement", + "lysine", + "positively", + "stabilizing", + "overall", + "aspartate", + "helix", "crucial", + "family", + "rearrangement", + "level", + "magnetic", "contacts", - "isolated", - "lysine", - "fibril", - "chain", + "stability", "proteins", - "play", + "packing", "process", - "similarities", - "family", - "negatively", + "may", "registration", - "positively", + "lateral", + "fibril", + "triple", + "allowing", + "combination", + "simpler", + "energy", + "packed", + "work", + "spectroscopy", + "chain", "suggests", "simple", - "simpler", - "little", - "nuclear", - "collagen", - "structures", - "aspartate", - "charged", - "solution", - "resonance", + "fibrillization", "assembly", - "first", - "role", - "second", - "stability", + "fold", + "humans", + "carry", "amino", - "detailed", - "lateral", - "acids", - "may", - "landscape", - "observed", - "helical", - "using", - "nmr", - "energy", + "solution", "formation", - "packing", - "important", - "fibrillization", - "stabilization", - "overall", - "despite", - "magnetic", - "helices", + "understood", + "types", + "landscape", + "whereas", + "reveal", + "crystalline", "fibers", - "study", "collagens", - "axial", - "fold", - "carry", - "humans", - "spectroscopy", - "reveal", - "understood", - "adjacent", - "two", - "glutamate", - "deceptively", + "observed", + "structures", + "first", + "detailed", + "structure", + "important", + "crystallography", + "nmr", + "interactions", "state", - "significant", - "protein", - "dual", - "helix", - "differences", - "types", - "combination", - "distinct", "understanding", - "crystalline", - "side", - "folding", - "level", - "whereas" + "find", + "abundant", + "distinct", + "acids", + "glutamate", + "despite", + "second", + "significant" ], "release_date":"2011-12-28", "publication":"\"Structural insights into charge pair interactions in triple helical collagen-like proteins\", J.Biol.Chem., 287, 8039-8047", @@ -60074,95 +60148,95 @@ ], "subtitle":"Crystal structure of de novo designed mid1-apo1", "tags":[ - "metal binding protein", "homodimer", - "helix-turn-helix", "de novo protein", + "metal binding", + "helix-turn-helix", "de novo protein, metal binding protein", - "metal binding" + "metal binding protein" ], "keywords":[ + "affinity", + "well", + "mid1", + "presence", + "three", + "c\u03b1", + "\u03bcm", + "model", + "protein", + "binding", + "dissociation", + "site", + "forms", + "applications", + "crystal", + "shows", + "metal", + "however", + "agreement", + "computationally", + "dimer", + "medicine", + "overall", "matches", - "nm", + "approach", + "sites", "use", - "metal", - "increasing", - "designed", - "basic", - "mutation", - "crystal", - "target", + "may", + "interface", + "homodimer", "robustness", - "interactions", - "designing", - "structure", - "specifying", - "computationally", "monomer", - "however", - "affinity", - "biotechnology", - "histidines", - "without", - "nesg", - "\u00e5", + "tight", + "four", + "computational", "tools", - "medicine", - "point", - "presence", - "resulting", - "interface", - "orientation", - "symmetric", - "improving", + "zinc", + "task", + "designing", + "challenging", + "design", "30", - "three", "research", + "named", + "id", + "nm", + "good", + "orientation", + "point", + "mode", + "symmetric", + "resulted", + "incorporating", + "or37", + "describe", + "desired", + "increasing", + "mutation", + "designed", "form", - "shows", - "mid1", + "rmsd", + "basic", + "one", + "improving", + "rational", + "\u00e5", + "without", + "structure", "thereby", - "or37", - "resulted", - "four", - "challenging", - "may", - "4", - "mode", + "resulting", "closely", - "dimer", - "agreement", - "design", - "task", - "model", - "applications", - "describe", + "target", + "coordinate", + "interactions", + "4", + "nesg", + "histidines", "high", "constant", - "c\u03b1", - "good", - "coordinate", - "dissociation", - "sites", - "overall", - "one", - "approach", - "rational", - "tight", - "desired", - "named", - "\u03bcm", - "well", - "zinc", - "incorporating", - "id", - "binding", - "protein", - "homodimer", - "computational", - "site", - "forms", - "rmsd" + "specifying", + "biotechnology" ], "release_date":"2012-01-11", "publication":"\"Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer\", J.Am.Chem.Soc., 134, 375-385", @@ -60195,11 +60269,11 @@ "seq_thr_sim_designed":[ { "sim":100.0, - "partner":"3v1d" + "partner":"3v1c" }, { "sim":100.0, - "partner":"3v1c" + "partner":"3v1d" }, { "sim":100.0, @@ -60248,7 +60322,7 @@ ], "seq_max_sim_designed":{ "sim":100.0, - "partner":"3v1d" + "partner":"3v1c" }, "seq_max_sim_natural":{ "sim":66.0, @@ -60314,95 +60388,95 @@ ], "subtitle":"Crystal structure of de novo designed mid1-apo2", "tags":[ - "metal binding protein", "homodimer", - "helix-turn-helix", "de novo protein", + "metal binding", + "helix-turn-helix", "de novo protein, metal binding protein", - "metal binding" + "metal binding protein" ], "keywords":[ + "affinity", + "well", + "mid1", + "presence", + "three", + "c\u03b1", + "\u03bcm", + "model", + "protein", + "binding", + "dissociation", + "site", + "forms", + "applications", + "crystal", + "shows", + "metal", + "however", + "agreement", + "computationally", + "dimer", + "medicine", + "overall", "matches", - "nm", + "approach", + "sites", "use", - "metal", - "increasing", - "designed", - "basic", - "mutation", - "crystal", - "target", + "may", + "interface", + "homodimer", "robustness", - "interactions", - "designing", - "structure", - "specifying", - "computationally", "monomer", - "however", - "affinity", - "biotechnology", - "histidines", - "without", - "nesg", - "\u00e5", + "tight", + "four", + "computational", "tools", - "medicine", - "point", - "presence", - "resulting", - "interface", - "orientation", - "symmetric", - "improving", + "zinc", + "task", + "designing", + "challenging", + "design", "30", - "three", "research", + "named", + "id", + "nm", + "good", + "orientation", + "point", + "mode", + "symmetric", + "resulted", + "incorporating", + "or37", + "describe", + "desired", + "increasing", + "mutation", + "designed", "form", - "shows", - "mid1", + "rmsd", + "basic", + "one", + "improving", + "rational", + "\u00e5", + "without", + "structure", "thereby", - "or37", - "resulted", - "four", - "challenging", - "may", - "4", - "mode", + "resulting", "closely", - "dimer", - "agreement", - "design", - "task", - "model", - "applications", - "describe", + "target", + "coordinate", + "interactions", + "4", + "nesg", + "histidines", "high", "constant", - "c\u03b1", - "good", - "coordinate", - "dissociation", - "sites", - "overall", - "one", - "approach", - "rational", - "tight", - "desired", - "named", - "\u03bcm", - "well", - "zinc", - "incorporating", - "id", - "binding", - "protein", - "homodimer", - "computational", - "site", - "forms", - "rmsd" + "specifying", + "biotechnology" ], "release_date":"2012-01-11", "publication":"\"Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer\", J.Am.Chem.Soc., 134, 375-385", @@ -60435,11 +60509,11 @@ "seq_thr_sim_designed":[ { "sim":100.0, - "partner":"3v1d" + "partner":"3v1c" }, { "sim":100.0, - "partner":"3v1c" + "partner":"3v1d" }, { "sim":100.0, @@ -60491,7 +60565,7 @@ ], "seq_max_sim_designed":{ "sim":100.0, - "partner":"3v1d" + "partner":"3v1c" }, "seq_max_sim_natural":{ "sim":66.0, @@ -60557,96 +60631,96 @@ ], "subtitle":"Crystal structure of de novo designed mid1-zinc", "tags":[ - "metal binding protein", "homodimer", + "de novo protein", + "metal binding", "helix-turn-helix", "hydrolase", - "de novo protein", - "de novo protein, hydrolase", - "metal binding" + "metal binding protein", + "de novo protein, hydrolase" ], "keywords":[ + "affinity", + "well", + "mid1", + "presence", + "three", + "c\u03b1", + "\u03bcm", + "model", + "protein", + "binding", + "dissociation", + "site", + "forms", + "applications", + "crystal", + "shows", + "metal", + "however", + "agreement", + "computationally", + "dimer", + "medicine", + "overall", "matches", - "nm", + "approach", + "sites", "use", - "metal", - "increasing", - "designed", - "basic", - "mutation", - "crystal", - "target", + "may", + "interface", + "homodimer", "robustness", - "interactions", - "designing", - "structure", - "specifying", - "computationally", "monomer", - "however", - "affinity", - "biotechnology", - "histidines", - "without", - "nesg", - "\u00e5", + "tight", + "four", + "computational", "tools", - "medicine", - "point", - "presence", - "resulting", - "interface", - "orientation", - "symmetric", - "improving", + "zinc", + "task", + "designing", + "challenging", + "design", "30", - "three", "research", + "named", + "id", + "nm", + "good", + "orientation", + "point", + "mode", + "symmetric", + "resulted", + "incorporating", + "or37", + "describe", + "desired", + "increasing", + "mutation", + "designed", "form", - "shows", - "mid1", + "rmsd", + "basic", + "one", + "improving", + "rational", + "\u00e5", + "without", + "structure", "thereby", - "or37", - "resulted", - "four", - "challenging", - "may", - "4", - "mode", + "resulting", "closely", - "dimer", - "agreement", - "design", - "task", - "model", - "applications", - "describe", + "target", + "coordinate", + "interactions", + "4", + "nesg", + "histidines", "high", "constant", - "c\u03b1", - "good", - "coordinate", - "dissociation", - "sites", - "overall", - "one", - "approach", - "rational", - "tight", - "desired", - "named", - "\u03bcm", - "well", - "zinc", - "incorporating", - "id", - "binding", - "protein", - "homodimer", - "computational", - "site", - "forms", - "rmsd" + "specifying", + "biotechnology" ], "release_date":"2012-01-11", "publication":"\"Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer\", J.Am.Chem.Soc., 134, 375-385", @@ -60683,11 +60757,11 @@ }, { "sim":100.0, - "partner":"3v1b" + "partner":"3v1a" }, { "sim":100.0, - "partner":"3v1a" + "partner":"3v1b" }, { "sim":97.0, @@ -60798,94 +60872,94 @@ ], "subtitle":"Crystal structure of de novo designed mid1-cobalt", "tags":[ - "metal binding protein", "zinc homodimerization", - "helix-turn-helix", "de novo protein", - "de novo protein, metal binding protein" + "helix-turn-helix", + "de novo protein, metal binding protein", + "metal binding protein" ], "keywords":[ + "affinity", + "well", + "mid1", + "presence", + "three", + "c\u03b1", + "\u03bcm", + "model", + "protein", + "binding", + "dissociation", + "site", + "forms", + "applications", + "crystal", + "shows", + "metal", + "however", + "agreement", + "computationally", + "dimer", + "medicine", + "overall", "matches", - "nm", + "approach", + "sites", "use", - "metal", - "increasing", - "designed", - "basic", - "mutation", - "crystal", - "target", + "may", + "interface", + "homodimer", "robustness", - "interactions", - "designing", - "structure", - "specifying", - "computationally", "monomer", - "however", - "affinity", - "biotechnology", - "histidines", - "without", - "nesg", - "\u00e5", + "tight", + "four", + "computational", "tools", - "medicine", - "point", - "presence", - "resulting", - "interface", - "orientation", - "symmetric", - "improving", + "zinc", + "task", + "designing", + "challenging", + "design", "30", - "three", "research", + "named", + "id", + "nm", + "good", + "orientation", + "point", + "mode", + "symmetric", + "resulted", + "incorporating", + "or37", + "describe", + "desired", + "increasing", + "mutation", + "designed", "form", - "shows", - "mid1", + "rmsd", + "basic", + "one", + "improving", + "rational", + "\u00e5", + "without", + "structure", "thereby", - "or37", - "resulted", - "four", - "challenging", - "may", - "4", - "mode", + "resulting", "closely", - "dimer", - "agreement", - "design", - "task", - "model", - "applications", - "describe", + "target", + "coordinate", + "interactions", + "4", + "nesg", + "histidines", "high", "constant", - "c\u03b1", - "good", - "coordinate", - "dissociation", - "sites", - "overall", - "one", - "approach", - "rational", - "tight", - "desired", - "named", - "\u03bcm", - "well", - "zinc", - "incorporating", - "id", - "binding", - "protein", - "homodimer", - "computational", - "site", - "forms", - "rmsd" + "specifying", + "biotechnology" ], "release_date":"2012-01-11", "publication":"\"Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer\", J.Am.Chem.Soc., 134, 375-385", @@ -60922,11 +60996,11 @@ }, { "sim":100.0, - "partner":"3v1b" + "partner":"3v1a" }, { "sim":100.0, - "partner":"3v1a" + "partner":"3v1b" }, { "sim":97.0, @@ -61037,95 +61111,95 @@ ], "subtitle":"Crystal structure of de novo designed mid1-zinc h12e mutant", "tags":[ - "metal binding protein", "homodimer", - "helix-turn-helix", "de novo protein", + "metal binding", + "helix-turn-helix", "de novo protein, metal binding protein", - "metal binding" + "metal binding protein" ], "keywords":[ + "affinity", + "well", + "mid1", + "presence", + "three", + "c\u03b1", + "\u03bcm", + "model", + "protein", + "binding", + "dissociation", + "site", + "forms", + "applications", + "crystal", + "shows", + "metal", + "however", + "agreement", + "computationally", + "dimer", + "medicine", + "overall", "matches", - "nm", + "approach", + "sites", "use", - "metal", - "increasing", - "designed", - "basic", - "mutation", - "crystal", - "target", + "may", + "interface", + "homodimer", "robustness", - "interactions", - "designing", - "structure", - "specifying", - "computationally", "monomer", - "however", - "affinity", - "biotechnology", - "histidines", - "without", - "nesg", - "\u00e5", + "tight", + "four", + "computational", "tools", - "medicine", - "point", - "presence", - "resulting", - "interface", - "orientation", - "symmetric", - "improving", + "zinc", + "task", + "designing", + "challenging", + "design", "30", - "three", "research", + "named", + "id", + "nm", + "good", + "orientation", + "point", + "mode", + "symmetric", + "resulted", + "incorporating", + "or37", + "describe", + "desired", + "increasing", + "mutation", + "designed", "form", - "shows", - "mid1", + "rmsd", + "basic", + "one", + "improving", + "rational", + "\u00e5", + "without", + "structure", "thereby", - "or37", - "resulted", - "four", - "challenging", - "may", - "4", - "mode", + "resulting", "closely", - "dimer", - "agreement", - "design", - "task", - "model", - "applications", - "describe", + "target", + "coordinate", + "interactions", + "4", + "nesg", + "histidines", "high", "constant", - "c\u03b1", - "good", - "coordinate", - "dissociation", - "sites", - "overall", - "one", - "approach", - "rational", - "tight", - "desired", - "named", - "\u03bcm", - "well", - "zinc", - "incorporating", - "id", - "binding", - "protein", - "homodimer", - "computational", - "site", - "forms", - "rmsd" + "specifying", + "biotechnology" ], "release_date":"2012-01-11", "publication":"\"Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer\", J.Am.Chem.Soc., 134, 375-385", @@ -61158,19 +61232,19 @@ "seq_thr_sim_designed":[ { "sim":97.0, - "partner":"3v1d" + "partner":"3v1c" }, { "sim":97.0, - "partner":"3v1c" + "partner":"3v1d" }, { "sim":97.0, - "partner":"3v1b" + "partner":"3v1a" }, { "sim":97.0, - "partner":"3v1a" + "partner":"3v1b" }, { "sim":94.0, @@ -61229,7 +61303,7 @@ ], "seq_max_sim_designed":{ "sim":97.0, - "partner":"3v1d" + "partner":"3v1c" }, "seq_max_sim_natural":{ "sim":66.0, @@ -61295,95 +61369,95 @@ ], "subtitle":"Crystal structure of de novo designed mid1-zinc h35e mutant", "tags":[ - "metal binding protein", "homodimer", - "helix-turn-helix", "de novo protein", + "metal binding", + "helix-turn-helix", "de novo protein, metal binding protein", - "metal binding" + "metal binding protein" ], "keywords":[ + "affinity", + "well", + "mid1", + "presence", + "three", + "c\u03b1", + "\u03bcm", + "model", + "protein", + "binding", + "dissociation", + "site", + "forms", + "applications", + "crystal", + "shows", + "metal", + "however", + "agreement", + "computationally", + "dimer", + "medicine", + "overall", "matches", - "nm", + "approach", + "sites", "use", - "metal", - "increasing", - "designed", - "basic", - "mutation", - "crystal", - "target", + "may", + "interface", + "homodimer", "robustness", - "interactions", - "designing", - "structure", - "specifying", - "computationally", "monomer", - "however", - "affinity", - "biotechnology", - "histidines", - "without", - "nesg", - "\u00e5", + "tight", + "four", + "computational", "tools", - "medicine", - "point", - "presence", - "resulting", - "interface", - "orientation", - "symmetric", - "improving", + "zinc", + "task", + "designing", + "challenging", + "design", "30", - "three", "research", + "named", + "id", + "nm", + "good", + "orientation", + "point", + "mode", + "symmetric", + "resulted", + "incorporating", + "or37", + "describe", + "desired", + "increasing", + "mutation", + "designed", "form", - "shows", - "mid1", + "rmsd", + "basic", + "one", + "improving", + "rational", + "\u00e5", + "without", + "structure", "thereby", - "or37", - "resulted", - "four", - "challenging", - "may", - "4", - "mode", + "resulting", "closely", - "dimer", - "agreement", - "design", - "task", - "model", - "applications", - "describe", + "target", + "coordinate", + "interactions", + "4", + "nesg", + "histidines", "high", "constant", - "c\u03b1", - "good", - "coordinate", - "dissociation", - "sites", - "overall", - "one", - "approach", - "rational", - "tight", - "desired", - "named", - "\u03bcm", - "well", - "zinc", - "incorporating", - "id", - "binding", - "protein", - "homodimer", - "computational", - "site", - "forms", - "rmsd" + "specifying", + "biotechnology" ], "release_date":"2012-01-11", "publication":"\"Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer\", J.Am.Chem.Soc., 134, 375-385", @@ -61416,19 +61490,19 @@ "seq_thr_sim_designed":[ { "sim":97.0, - "partner":"3v1d" + "partner":"3v1c" }, { "sim":97.0, - "partner":"3v1c" + "partner":"3v1d" }, { "sim":97.0, - "partner":"3v1b" + "partner":"3v1a" }, { "sim":97.0, - "partner":"3v1a" + "partner":"3v1b" }, { "sim":94.0, @@ -61436,11 +61510,11 @@ }, { "sim":79.0, - "partner":"5od9" + "partner":"7bww" }, { "sim":79.0, - "partner":"7bww" + "partner":"5od9" }, { "sim":77.0, @@ -61476,7 +61550,7 @@ ], "seq_max_sim_designed":{ "sim":97.0, - "partner":"3v1d" + "partner":"3v1c" }, "seq_max_sim_natural":{ "sim":66.0, @@ -61571,100 +61645,100 @@ ], "subtitle":"Crystal structure of de novo designed serine hydrolase osh55, northeast structural genomics consortium target or130", "tags":[ - "northeast structural genomics consortium", - "structural genomics", - "protein structure initiative", - "de novo protein", + "de novo design", "nesg", + "de novo protein", + "northeast structural genomics consortium", "psi-biology", - "de novo design" + "structural genomics", + "protein structure initiative" ], "keywords":[ - "fluorophosphate", - "many", - "multiple", - "must", - "suggest", - "idealized", - "challenge", - "including", - "provide", - "triads", - "crystal", + "triad", "limited", + "yeast", + "optimized", "show", - "basis", + "single", + "multiple", + "idealized", + "simultaneously", "assess", - "display", + "nucleophilicity", + "residue", + "new", + "probes", + "hydrolases", + "product", + "binding", + "focus", + "following", + "stabilization", + "initiates", + "extensive", + "site", "networks", - "catalysis", - "rates", - "proteins", - "models", - "enzymes", + "demonstrate", + "systems", + "catalytic", + "crystal", + "using", "reactivity", - "focus", - "absolute", - "substrate", - "bonding", - "comparable", - "structures", + "agreement", + "react", + "biological", + "residues", "capture", - "natural", - "organophosphate", - "native", "transition", - "extensive", - "simultaneously", - "systems", - "hydrogen", - "triad", - "properties", - "following", - "diisopropyl", - "directly", - "serine", "release", - "catalytic", - "class", + "organophosphate", "optimization", + "basis", + "bound", + "proteins", + "enzymes", + "hydrogen", + "activation", + "suggest", + "absolute", + "unprecedented", + "computational", + "rates", + "serine", + "including", + "bonding", + "property", + "mutagenesis", + "agents", + "design", + "critical", + "must", "active", + "natural", + "substrate", + "display", + "properties", + "experiments", "successful", - "agreement", - "activity", - "design", + "quartet", + "diisopropyl", "nucleophile", - "using", - "agents", - "initiates", - "biological", - "property", + "catalysis", "could", - "stabilization", - "demonstrate", - "designs", - "nucleophilicity", - "critical", - "optimized", - "single", - "unprecedented", - "product", - "experiments", - "residues", - "react", + "directly", + "fluorophosphate", + "models", + "many", + "structures", + "comparable", + "provide", "state", - "hydrolases", - "quartet", - "bound", - "residue", - "binding", - "computational", - "yeast", - "activation", - "site", - "probes", - "mutagenesis", - "new" + "class", + "activity", + "native", + "triads", + "challenge", + "designs" ], "release_date":"2012-01-04", "publication":"\"Design of activated serine-containing catalytic triads with atomic-level accuracy\", Nat.Chem.Biol., 10, 386-391", @@ -61786,103 +61860,103 @@ "tags":[ "helical coil", "de novo protein", - "computational design of a protein crystal", - "de novo designed helix" + "de novo designed helix", + "computational design of a protein crystal" ], "keywords":[ - "minima", - "macroscopic", - "analysis", - "predetermined", - "channels", - "herein", + "molecular", + "structural", + "development", + "resolution", "candidate", - "designed", - "programmed", - "dimensions", - "experimentally", - "crystal", - "potential", - "hexameric", - "ii", - "sequences", - "interactions", - "designing", - "structure", - "therapeutic", - "consistent", - "characterizing", - "modification", - "proteins", - "presented", - "de", - "\u00e5", - "atoms", - "square", - "highly", - "targeted", - "materials", - "often", - "structures", - "positions", - "natural", - "complexity", + "group", + "precision", "three", - "involves", - "biology", - "designable", - "form", - "facilitate", - "crystallization", - "molecular", + "deviation", + "mean", "exhibits", - "group", - "resolution", + "span", + "root", + "model", + "protein", + "positions", + "given", + "novo", "catalytic", - "identify", - "engineer", - "landscape", - "iii", - "agreement", + "applications", + "crystal", + "creating", + "complex", "nanoscale", - "provides", - "design", "govern", - "model", - "crystallographic", - "applications", + "efforts", + "agreement", + "experimentally", + "consistent", + "polar", + "designable", + "approach", + "proteins", + "iii", + "highly", + "minima", + "ensemble", + "square", + "computational", + "p6", + "facilitate", + "hexameric", + "designing", "symmetry", + "design", "energy", - "root", - "ensemble", - "structural", - "layered", + "subtle", + "provides", "nanostructured", + "biology", + "natural", + "potential", + "atoms", + "therapeutic", + "complexity", + "macroscopic", + "backbone", "noncovalent", - "one", - "subtle", - "approach", - "novo", - "efforts", - "deviation", - "precision", - "p6", - "creating", + "channels", + "landscape", + "crystals", + "predetermined", + "materials", + "crystallographic", + "engineer", + "designed", + "form", + "crystalline", "central", - "polar", - "span", - "protein", - "yield", - "given", - "complex", - "backbone", + "rmsd", + "analysis", + "often", + "dimensions", + "involves", + "sequences", + "modification", "space", - "development", - "mean", - "computational", - "crystalline", - "crystals", - "rmsd" + "one", + "targeted", + "structures", + "de", + "\u00e5", + "crystallization", + "structure", + "herein", + "interactions", + "yield", + "programmed", + "presented", + "identify", + "characterizing", + "layered", + "ii" ], "release_date":"2012-05-09", "publication":"\"Computational design of a protein crystal\", Proc.Natl.Acad.Sci.USA, 109, 7304-7309", @@ -62017,84 +62091,84 @@ ], "subtitle":"Crystal structure of engineered protein, northeast structural genomics consortium target or43", "tags":[ + "nesg", + "de novo protein", "northeast structural genomics consortium", "structural genomics", - "de novo protein", - "nesg", "psi-biology" ], "keywords":[ - "inhibits", - "saturation", - "following", - "considerable", - "demonstrated", - "acidic", - "supports", - "amino", - "proteins", + "affinity", + "designed", + "extending", + "surface", + "grafted", "surrounding", - "studies", + "designing", + "finally", + "mutagenesis", + "design", "critical", - "low", - "process", - "contact", + "fit", + "egg", + "knockout", "selection", - "challenge", - "optimizes", - "crystallography", - "enzyme", - "acids", - "shape", - "finally", - "designed", - "method", + "active", + "hen", "well", - "grafted", - "confirmed", + "progress", "residues", - "surfaces", - "active", - "lysozyme", - "knockout", - "orientation", - "region", - "beyond", - "binds", - "two", - "complementary", "specific", + "acidic", + "shape", "polar", - "scaffold", - "design", - "centrally", - "nanomolar", - "binding", + "orientation", + "beyond", + "surfaces", + "supports", + "nmr", "interactions", - "bind", "protein", - "hen", - "using", + "starts", + "maturation", + "crystallography", + "bind", + "amino", "bound", - "progress", - "nmr", - "designing", - "surface", - "describe", - "unmet", + "proteins", + "binding", + "process", + "following", + "low", + "considerable", + "site", + "confirmed", "sequencing", - "maturation", - "fit", - "combination", - "computational", + "scaffold", + "enzyme", + "demonstrated", + "optimizes", + "contact", + "acids", + "centrally", + "two", + "studies", + "saturation", + "region", + "lysozyme", + "describe", + "binds", "identifies", - "egg", - "starts", - "extending", - "deep", - "affinity", - "site", - "mutagenesis" + "challenge", + "nanomolar", + "method", + "complementary", + "computational", + "inhibits", + "using", + "combination", + "unmet", + "deep" ], "release_date":"2012-06-06", "publication":"\"Computational design of a protein-based enzyme inhibitor\", J.Mol.Biol., 425, 3563-3575", @@ -62231,57 +62305,57 @@ ], "subtitle":"Computationally designed self-assembling octahedral cage protein, o333, crystallized in space group r32", "tags":[ - "self assembling octahedral cage design", - "electron transport" + "electron transport", + "self assembling octahedral cage design" ], "keywords":[ - "interfaces", - "general", - "proteins", + "designed", + "trimeric", + "complex", + "designing", "models", - "architecture", + "order", + "symmetry", + "design", + "revealed", + "interfaces", + "used", + "structures", "complexes", - "wide", - "desired", - "identify", - "method", - "together", - "designed", - "diameter", + "oligomeric", "resulting", - "used", "closely", - "complementary", - "symmetric", - "materials", - "crystal", - "arrangements", - "blocks", - "match", + "assembled", "drive", - "design", - "order", - "symmetrically", - "trimeric", - "structures", "protein", "tetrahedral", - "assembled", - "states", - "complex", - "designing", - "symmetry", - "docked", - "describe", + "symmetrically", + "wide", + "blocks", + "proteins", + "symmetric", + "packing", "solution", - "variety", "nanomaterials", - "revealed", - "computational", - "oligomeric", + "together", + "identify", + "architecture", + "general", + "diameter", "building", "octahedral", - "packing" + "states", + "match", + "docked", + "variety", + "crystal", + "describe", + "arrangements", + "materials", + "desired", + "method", + "complementary", + "computational" ], "release_date":"2012-06-06", "publication":"\"Computational design of self-assembling protein nanomaterials with atomic level accuracy\", Science, 336, 1171-1174", @@ -62401,105 +62475,105 @@ "tags":[ "rudimentary enzymatic activities", "four helix bundle", - "3d domain swapping", "de novo protein", - "protein design", - "binary patterned design" + "3d domain swapping", + "binary patterned design", + "protein design" ], "keywords":[ - "anomalous", - "monomeric", - "results", - "nm", - "indicating", - "long", - "scattering", + "picked", + "genes", + "escherichia", + "molecular", + "hydrophobic", + "probe", "dispersion", - "lipase", "acid", - "expressed", - "designed", - "patterning", - "provide", + "results", + "protein", + "activities", + "pockets", + "helical", + "binding", + "together", + "weight", + "novo", + "demonstrate", + "forms", "potentially", - "dimeric", - "max", - "contains", + "two", "crystal", - "determined", - "potential", - "probe", - "synthetic", + "stable", + "helices", + "lipase", + "using", "multiwavelength", - "structure", - "escherichia", - "intertwist", - "monomer", - "wa20", "binary", + "shows", + "bundles", + "dimer", + "comprises", + "residues", + "polar", + "library", + "max", "proteins", + "sites", + "rudimentary", + "unexpectedly", + "scattering", + "may", + "contains", "combinatorial", - "de", - "superfamily", + "created", + "monomer", + "long", + "bundle", + "wa20", + "length", + "functional", + "simple", "substrate", + "anomalous", + "potential", + "intertwist", + "monomers", + "nm", + "addition", + "indicating", + "third", + "also", + "amino", + "superfamily", + "nonpolar", "kda", - "simple", - "rudimentary", - "pockets", "solution", + "coli", + "sequence", + "maximum", + "3d", + "method", + "unevolved", + "designed", "form", - "shows", - "multimeric", - "created", - "esterase", - "monomers", "generation", - "molecular", - "maximum", - "functional", - "amino", - "coli", - "bundles", + "space", + "one", + "esterase", + "de", + "expressed", + "structure", + "synthetic", + "monomeric", "report", - "artificial", - "activities", - "method", + "provide", + "determined", "shape", - "may", - "dimer", + "patterning", + "multimeric", + "artificial", "activity", - "bundle", - "weight", - "helical", - "using", - "hydrophobic", - "sequence", - "genes", - "unevolved", - "sites", - "library", - "3d", - "nonpolar", - "demonstrate", - "one", - "helices", - "unexpectedly", - "also", - "novo", - "stable", - "length", - "together", - "residues", - "two", - "comprises", - "polar", - "addition", - "picked", - "protein", - "space", - "third", - "binding", - "forms" + "dimeric" ], "release_date":"2012-03-28", "publication":"\"Domain-swapped dimeric structure of a stable and functional de novo four-helix bundle protein, WA20\", J.Phys.Chem.B, 116, 6789-6797", @@ -62536,15 +62610,15 @@ }, { "sim":105.0, - "partner":"8h7d" + "partner":"8h7e" }, { "sim":105.0, - "partner":"8h7e" + "partner":"8h7c" }, { "sim":105.0, - "partner":"8h7c" + "partner":"8h7d" } ], "seq_thr_sim_natural":[ @@ -62615,77 +62689,77 @@ "subtitle":"Crystal structure of collagen-model peptide, (pog)3-prg-(pog)4", "tags":[ "hsp47 binding", - "collagen-helix", - "structural protein" + "structural protein", + "collagen-helix" ], "keywords":[ - "statistical", + "molecule", + "designed", + "\u03c71", + "asymmetric", + "alternative", + "conformation", "analysis", + "adopt", + "shows", + "unlike", "many", "one", - "strand", - "proteins", - "separated", - "unique", - "difference", - "also", - "der", - "host", - "globular", "resolution", - "asymmetric", - "\u00e5", - "four", - "peptide", - "among", - "tt", - "peptides", - "designed", - "\u03c71", - "4", - "atoms", - "waals", - "residues", - "permits", - "ttg", - "near", - "adjacent", - "g", + "\u03c72", + "observed", "80", - "crystal", "3", - "tg", + "arg", + "waals", + "three", + "\u00e5", + "residues", + "structure", + "atoms", + "among", + "guest", + "preferentially", "determined", - "permit", + "host", + "residue", + "also", + "various", + "contacts", + "globular", + "4", "unit", - "observed", - "significant", + "proteins", + "tg", "helical", - "away", - "residue", - "conformation", - "adopt", - "suggested", - "adopts", - "van", - "structure", - "three", + "permit", + "investigation", "showed", + "ttg", + "strand", + "van", + "adopts", + "permits", + "significant", + "difference", "marked", - "various", - "\u03c72", - "twists", - "affects", - "unlike", - "shows", - "investigation", - "guest", - "preferentially", - "alternative", + "peptides", + "der", + "suggested", "conformations", - "molecule", - "contacts", - "arg" + "near", + "affects", + "tt", + "crystal", + "twists", + "separated", + "unique", + "four", + "g", + "adjacent", + "away", + "peptide", + "statistical" ], "release_date":"2014-08-13", "publication":"\"Preferred side-chain conformation of arginine residues in a triple-helical structure\", Biopolymers, 101, 1000-1009", @@ -62808,83 +62882,83 @@ "computational protein design" ], "keywords":[ - "evolution", - "intermediate", - "many", - "architecture", + "templates", + "role", + "therefore", "complexes", - "crystallography", + "families", + "three", + "new", + "symmetrical", + "protein", + "rapid", "test", - "expressed", - "carrying", + "forms", + "two", "purified", - "experimentally", - "180", - "therefore", - "structure", - "sixfold", - "duplication", - "however", - "consistent", - "42", - "proteins", - "failed", - "produce", - "strongly", - "kda", - "highly", - "simple", - "assemble", "procedure", - "symmetrical", - "attempts", - "recreate", - "templates", - "perfectly", - "three", - "suitable", - "fusion", - "size", - "blade", - "role", - "implies", + "stable", + "theory", + "played", "rules", - "created", - "rapid", - "blades", - "propeller", - "families", - "tandem", - "according", - "blocks", - "design", "using", - "symmetry", - "important", + "creating", + "previous", "monodisperse", + "however", + "perfectly", + "experimentally", + "residues", + "case", + "strongly", "approach", - "also", - "stable", - "desired", + "blocks", + "proteins", + "size", "modular", + "tandem", + "architecture", + "highly", + "created", + "carrying", + "evolution", + "duplication", + "recreate", + "computational", + "consists", + "symmetry", + "design", + "propeller", + "fusion", + "simple", + "produce", "different", - "residues", - "played", - "two", + "also", + "180", + "failed", + "kda", "leading", "validated", - "creating", - "protein", - "previous", "identical", - "theory", - "computational", - "consists", - "case", "developed", + "desired", + "implies", + "blades", + "many", + "suitable", + "expressed", + "attempts", + "sixfold", + "structure", + "important", + "according", + "crystallography", + "42", + "intermediate", + "blade", + "assemble", "create", - "forms", - "new" + "consistent" ], "release_date":"2014-10-08", "publication":"\"Computational design of a self-assembling symmetrical beta-propeller protein\", Proc.Natl.Acad.Sci.USA, 111, 15102-15107", @@ -62930,76 +63004,92 @@ "partner":"3wwb" }, { - "sim":0.9954000115, - "partner":"3ww8" + "sim":0.99150002, + "partner":"7zcj" }, { - "sim":0.9797999859, - "partner":"6i39" + "sim":0.9968000054, + "partner":"3wwa" }, { - "sim":0.9940999746, - "partner":"6rem" + "sim":0.9962999821, + "partner":"6qsg" }, { - "sim":0.9862999916, - "partner":"6reg" + "sim":0.9858999848, + "partner":"6rei" }, { - "sim":0.99150002, - "partner":"7zcj" + "sim":0.9684000015, + "partner":"6rej" }, { - "sim":0.9679999948, - "partner":"6i37" + "sim":0.9728000164, + "partner":"6rek" + }, + { + "sim":0.9700999856, + "partner":"6rel" }, { "sim":0.989199996, "partner":"6f0t" }, { - "sim":0.9944999814, - "partner":"6qsd" + "sim":0.9848999977, + "partner":"7ov7" }, { - "sim":0.9552999735, - "partner":"4zcn" + "sim":0.9862999916, + "partner":"6reg" + }, + { + "sim":0.9955000281, + "partner":"6qse" + }, + { + "sim":0.9880999923, + "partner":"7zpw" }, { "sim":0.9904000163, "partner":"6rli" }, { - "sim":0.9848999977, - "partner":"7ov7" + "sim":0.9944999814, + "partner":"6qsd" }, { - "sim":0.9955000281, - "partner":"6qse" + "sim":0.9858000278, + "partner":"6reh" }, { - "sim":0.9880999923, - "partner":"7zpw" + "sim":0.9954000115, + "partner":"3ww8" }, { - "sim":0.9962999821, - "partner":"6qsg" + "sim":0.9797999859, + "partner":"6i39" }, { - "sim":0.9746000171, - "partner":"7zqg" + "sim":0.9940999746, + "partner":"6rem" }, { - "sim":0.9857000113, - "partner":"6rlh" + "sim":0.9679999948, + "partner":"6i37" }, { - "sim":0.9858999848, - "partner":"6rei" + "sim":0.9552999735, + "partner":"4zcn" }, { - "sim":0.9858000278, - "partner":"6reh" + "sim":0.9746000171, + "partner":"7zqg" + }, + { + "sim":0.9857000113, + "partner":"6rlh" }, { "sim":0.9764999747, @@ -63029,10 +63119,6 @@ "sim":0.9638000131, "partner":"7zph" }, - { - "sim":0.9968000054, - "partner":"3wwa" - }, { "sim":0.9510999918, "partner":"5i1z" @@ -63041,22 +63127,10 @@ "sim":0.9600999951, "partner":"3ww9" }, - { - "sim":0.9700999856, - "partner":"6rel" - }, { "sim":0.9708999991, "partner":"6ren" }, - { - "sim":0.9684000015, - "partner":"6rej" - }, - { - "sim":0.9728000164, - "partner":"6rek" - }, { "sim":0.9664000273, "partner":"7zq2" @@ -63171,83 +63245,83 @@ "computational protein design" ], "keywords":[ - "evolution", - "intermediate", - "many", - "architecture", + "templates", + "role", + "therefore", "complexes", - "crystallography", + "families", + "three", + "new", + "symmetrical", + "protein", + "rapid", "test", - "expressed", - "carrying", + "forms", + "two", "purified", - "experimentally", - "180", - "therefore", - "structure", - "sixfold", - "duplication", - "however", - "consistent", - "42", - "proteins", - "failed", - "produce", - "strongly", - "kda", - "highly", - "simple", - "assemble", "procedure", - "symmetrical", - "attempts", - "recreate", - "templates", - "perfectly", - "three", - "suitable", - "fusion", - "size", - "blade", - "role", - "implies", + "stable", + "theory", + "played", "rules", - "created", - "rapid", - "blades", - "propeller", - "families", - "tandem", - "according", - "blocks", - "design", "using", - "symmetry", - "important", + "creating", + "previous", "monodisperse", + "however", + "perfectly", + "experimentally", + "residues", + "case", + "strongly", "approach", - "also", - "stable", - "desired", + "blocks", + "proteins", + "size", "modular", + "tandem", + "architecture", + "highly", + "created", + "carrying", + "evolution", + "duplication", + "recreate", + "computational", + "consists", + "symmetry", + "design", + "propeller", + "fusion", + "simple", + "produce", "different", - "residues", - "played", - "two", + "also", + "180", + "failed", + "kda", "leading", "validated", - "creating", - "protein", - "previous", "identical", - "theory", - "computational", - "consists", - "case", "developed", + "desired", + "implies", + "blades", + "many", + "suitable", + "expressed", + "attempts", + "sixfold", + "structure", + "important", + "according", + "crystallography", + "42", + "intermediate", + "blade", + "assemble", "create", - "forms", - "new" + "consistent" ], "release_date":"2014-10-08", "publication":"\"Computational design of a self-assembling symmetrical beta-propeller protein\", Proc.Natl.Acad.Sci.USA, 111, 15102-15107", @@ -63293,48 +63367,12 @@ "partner":"6rem" }, { - "sim":0.9897000194, - "partner":"6qsd" + "sim":0.9775999784, + "partner":"6reh" }, { - "sim":0.9743999839, - "partner":"6f0t" - }, - { - "sim":0.9933999777, - "partner":"6rej" - }, - { - "sim":0.9589999914, - "partner":"3wwa" - }, - { - "sim":0.9904999733, - "partner":"6qse" - }, - { - "sim":0.9641000032, - "partner":"6rel" - }, - { - "sim":0.9562000036, - "partner":"7zcj" - }, - { - "sim":0.9528999925, - "partner":"6i38" - }, - { - "sim":0.983099997, - "partner":"7zpw" - }, - { - "sim":0.9775999784, - "partner":"6reh" - }, - { - "sim":0.9890999794, - "partner":"6rei" + "sim":0.9890999794, + "partner":"6rei" }, { "sim":0.9897000194, @@ -63352,6 +63390,10 @@ "sim":0.9692999721, "partner":"6i39" }, + { + "sim":0.9904999733, + "partner":"6qse" + }, { "sim":0.981400013, "partner":"6reg" @@ -63360,14 +63402,26 @@ "sim":0.9603999853, "partner":"6reo" }, + { + "sim":0.983099997, + "partner":"7zpw" + }, { "sim":0.9679999948, "partner":"7zqg" }, + { + "sim":0.9641000032, + "partner":"6rel" + }, { "sim":0.956099987, "partner":"6i3b" }, + { + "sim":0.9589999914, + "partner":"3wwa" + }, { "sim":0.980700016, "partner":"6rlh" @@ -63392,6 +63446,22 @@ "sim":0.9800999761, "partner":"6qsg" }, + { + "sim":0.9743999839, + "partner":"6f0t" + }, + { + "sim":0.9897000194, + "partner":"6qsd" + }, + { + "sim":0.9562000036, + "partner":"7zcj" + }, + { + "sim":0.9933999777, + "partner":"6rej" + }, { "sim":0.9577000141, "partner":"6qsf" @@ -63407,6 +63477,10 @@ { "sim":0.9595000148, "partner":"6rek" + }, + { + "sim":0.9528999925, + "partner":"6i38" } ], "struct_thr_sim_natural":[ @@ -63495,83 +63569,83 @@ "computational protein design" ], "keywords":[ - "evolution", - "intermediate", - "many", - "architecture", + "templates", + "role", + "therefore", "complexes", - "crystallography", + "families", + "three", + "new", + "symmetrical", + "protein", + "rapid", "test", - "expressed", - "carrying", + "forms", + "two", "purified", - "experimentally", - "180", - "therefore", - "structure", - "sixfold", - "duplication", - "however", - "consistent", - "42", - "proteins", - "failed", - "produce", - "strongly", - "kda", - "highly", - "simple", - "assemble", "procedure", - "symmetrical", - "attempts", - "recreate", - "templates", - "perfectly", - "three", - "suitable", - "fusion", - "size", - "blade", - "role", - "implies", + "stable", + "theory", + "played", "rules", - "created", - "rapid", - "blades", - "propeller", - "families", - "tandem", - "according", - "blocks", - "design", "using", - "symmetry", - "important", + "creating", + "previous", "monodisperse", + "however", + "perfectly", + "experimentally", + "residues", + "case", + "strongly", "approach", - "also", - "stable", - "desired", + "blocks", + "proteins", + "size", "modular", + "tandem", + "architecture", + "highly", + "created", + "carrying", + "evolution", + "duplication", + "recreate", + "computational", + "consists", + "symmetry", + "design", + "propeller", + "fusion", + "simple", + "produce", "different", - "residues", - "played", - "two", + "also", + "180", + "failed", + "kda", "leading", "validated", - "creating", - "protein", - "previous", "identical", - "theory", - "computational", - "consists", - "case", "developed", + "desired", + "implies", + "blades", + "many", + "suitable", + "expressed", + "attempts", + "sixfold", + "structure", + "important", + "according", + "crystallography", + "42", + "intermediate", + "blade", + "assemble", "create", - "forms", - "new" + "consistent" ], "release_date":"2014-10-08", "publication":"\"Computational design of a self-assembling symmetrical beta-propeller protein\", Proc.Natl.Acad.Sci.USA, 111, 15102-15107", @@ -63747,83 +63821,83 @@ "computational protein design" ], "keywords":[ - "evolution", - "intermediate", - "many", - "architecture", + "templates", + "role", + "therefore", "complexes", - "crystallography", + "families", + "three", + "new", + "symmetrical", + "protein", + "rapid", "test", - "expressed", - "carrying", + "forms", + "two", "purified", - "experimentally", - "180", - "therefore", - "structure", - "sixfold", - "duplication", - "however", - "consistent", - "42", - "proteins", - "failed", - "produce", - "strongly", - "kda", - "highly", - "simple", - "assemble", "procedure", - "symmetrical", - "attempts", - "recreate", - "templates", - "perfectly", - "three", - "suitable", - "fusion", - "size", - "blade", - "role", - "implies", + "stable", + "theory", + "played", "rules", - "created", - "rapid", - "blades", - "propeller", - "families", - "tandem", - "according", - "blocks", - "design", "using", - "symmetry", - "important", + "creating", + "previous", "monodisperse", + "however", + "perfectly", + "experimentally", + "residues", + "case", + "strongly", "approach", - "also", - "stable", - "desired", + "blocks", + "proteins", + "size", "modular", + "tandem", + "architecture", + "highly", + "created", + "carrying", + "evolution", + "duplication", + "recreate", + "computational", + "consists", + "symmetry", + "design", + "propeller", + "fusion", + "simple", + "produce", "different", - "residues", - "played", - "two", + "also", + "180", + "failed", + "kda", "leading", "validated", - "creating", - "protein", - "previous", "identical", - "theory", - "computational", - "consists", - "case", "developed", + "desired", + "implies", + "blades", + "many", + "suitable", + "expressed", + "attempts", + "sixfold", + "structure", + "important", + "according", + "crystallography", + "42", + "intermediate", + "blade", + "assemble", "create", - "forms", - "new" + "consistent" ], "release_date":"2014-10-08", "publication":"\"Computational design of a self-assembling symmetrical beta-propeller protein\", Proc.Natl.Acad.Sci.USA, 111, 15102-15107", @@ -63991,83 +64065,83 @@ "computational protein design" ], "keywords":[ - "evolution", - "intermediate", - "many", - "architecture", + "templates", + "role", + "therefore", "complexes", - "crystallography", + "families", + "three", + "new", + "symmetrical", + "protein", + "rapid", "test", - "expressed", - "carrying", + "forms", + "two", "purified", - "experimentally", - "180", - "therefore", - "structure", - "sixfold", - "duplication", - "however", - "consistent", - "42", - "proteins", - "failed", - "produce", - "strongly", - "kda", - "highly", - "simple", - "assemble", "procedure", - "symmetrical", - "attempts", - "recreate", - "templates", - "perfectly", - "three", - "suitable", - "fusion", - "size", - "blade", - "role", - "implies", + "stable", + "theory", + "played", "rules", - "created", - "rapid", - "blades", - "propeller", - "families", - "tandem", - "according", - "blocks", - "design", "using", - "symmetry", - "important", + "creating", + "previous", "monodisperse", + "however", + "perfectly", + "experimentally", + "residues", + "case", + "strongly", "approach", - "also", - "stable", - "desired", + "blocks", + "proteins", + "size", "modular", + "tandem", + "architecture", + "highly", + "created", + "carrying", + "evolution", + "duplication", + "recreate", + "computational", + "consists", + "symmetry", + "design", + "propeller", + "fusion", + "simple", + "produce", "different", - "residues", - "played", - "two", + "also", + "180", + "failed", + "kda", "leading", "validated", - "creating", - "protein", - "previous", "identical", - "theory", - "computational", - "consists", - "case", "developed", + "desired", + "implies", + "blades", + "many", + "suitable", + "expressed", + "attempts", + "sixfold", + "structure", + "important", + "according", + "crystallography", + "42", + "intermediate", + "blade", + "assemble", "create", - "forms", - "new" + "consistent" ], "release_date":"2014-10-08", "publication":"\"Computational design of a self-assembling symmetrical beta-propeller protein\", Proc.Natl.Acad.Sci.USA, 111, 15102-15107", @@ -64104,161 +64178,161 @@ ], "struct_thr_sim_designed":[ - { - "sim":0.9941999912, - "partner":"3ww7" - }, { "sim":0.9918000102, "partner":"3wwf" }, { - "sim":0.9908999801, - "partner":"6qse" + "sim":0.9941999912, + "partner":"3ww7" }, { - "sim":0.9925000072, - "partner":"6rem" + "sim":0.9887999892, + "partner":"3ww8" + }, + { + "sim":0.9944999814, + "partner":"6qsd" }, { "sim":0.9926000237, "partner":"6reg" }, { - "sim":0.9921000004, - "partner":"6f0t" + "sim":0.9896000028, + "partner":"7ov7" }, { - "sim":0.9707999825, - "partner":"6i3b" + "sim":0.9952999949, + "partner":"6qsg" }, { - "sim":0.9887999892, - "partner":"3ww8" + "sim":0.9526000023, + "partner":"4zcn" }, { "sim":0.9951999784, "partner":"7zcj" }, { - "sim":0.9728999734, - "partner":"6i3a" - }, - { - "sim":0.9853000045, - "partner":"3wwa" + "sim":0.9937000275, + "partner":"7zpw" }, { - "sim":0.9713000059, - "partner":"6f0q" + "sim":0.9925000072, + "partner":"6rem" }, { - "sim":0.9937000275, - "partner":"7zpw" + "sim":0.9751999974, + "partner":"6i39" }, { - "sim":0.9926999807, - "partner":"6rei" + "sim":0.9921000004, + "partner":"6f0t" }, { - "sim":0.9944999814, - "partner":"6qsd" + "sim":0.9908999801, + "partner":"6qse" }, { - "sim":0.9952999949, - "partner":"6qsg" + "sim":0.9926999807, + "partner":"6rei" }, { - "sim":0.9751999974, - "partner":"6rlh" + "sim":0.9616000056, + "partner":"5i1y" }, { - "sim":0.9937000275, - "partner":"6rli" + "sim":0.9746000171, + "partner":"7zph" }, { - "sim":0.9896000028, - "partner":"7ov7" + "sim":0.9817000031, + "partner":"7zpz" }, { "sim":0.9836999774, "partner":"6reh" }, { - "sim":0.9811000228, - "partner":"6rej" - }, - { - "sim":0.965200007, - "partner":"6rek" + "sim":0.9728999734, + "partner":"6i3a" }, { - "sim":0.9817000031, - "partner":"7zpz" + "sim":0.9707999825, + "partner":"6i3b" }, { - "sim":0.9819999933, - "partner":"6reo" + "sim":0.9864000082, + "partner":"3ww9" }, { - "sim":0.9531000257, - "partner":"6qsh" + "sim":0.9811000228, + "partner":"6rej" }, { - "sim":0.9751999974, - "partner":"6i39" + "sim":0.9937000275, + "partner":"6rli" }, { - "sim":0.9616000056, - "partner":"5i1y" + "sim":0.9713000059, + "partner":"6f0q" }, { - "sim":0.9526000023, - "partner":"4zcn" + "sim":0.9751999974, + "partner":"6rlh" }, { - "sim":0.9524999857, - "partner":"5i1z" + "sim":0.9580000043, + "partner":"6f0s" }, { - "sim":0.9549000263, - "partner":"5f53" + "sim":0.956700027, + "partner":"6i37" }, { "sim":0.9812999964, "partner":"7zqg" }, + { + "sim":0.9819999933, + "partner":"6reo" + }, { "sim":0.9649999738, "partner":"6i38" }, { - "sim":0.9580000043, - "partner":"6f0s" + "sim":0.9559000134, + "partner":"7zq2" }, { - "sim":0.9545000196, - "partner":"6rel" + "sim":0.9524999857, + "partner":"5i1z" + }, + { + "sim":0.9853000045, + "partner":"3wwa" }, { "sim":0.9650999904, "partner":"6qsf" }, { - "sim":0.956700027, - "partner":"6i37" + "sim":0.965200007, + "partner":"6rek" }, { - "sim":0.9746000171, - "partner":"7zph" + "sim":0.9545000196, + "partner":"6rel" }, { - "sim":0.9864000082, - "partner":"3ww9" + "sim":0.9549000263, + "partner":"5f53" }, { - "sim":0.9559000134, - "partner":"7zq2" + "sim":0.9531000257, + "partner":"6qsh" } ], "struct_thr_sim_natural":[ @@ -64354,83 +64428,83 @@ "computational protein design" ], "keywords":[ - "evolution", - "intermediate", - "many", - "architecture", + "templates", + "role", + "therefore", "complexes", - "crystallography", + "families", + "three", + "new", + "symmetrical", + "protein", + "rapid", "test", - "expressed", - "carrying", + "forms", + "two", "purified", - "experimentally", - "180", - "therefore", - "structure", - "sixfold", - "duplication", - "however", - "consistent", - "42", - "proteins", - "failed", - "produce", - "strongly", - "kda", - "highly", - "simple", - "assemble", "procedure", - "symmetrical", - "attempts", - "recreate", - "templates", - "perfectly", - "three", - "suitable", - "fusion", - "size", - "blade", - "role", - "implies", + "stable", + "theory", + "played", "rules", - "created", - "rapid", - "blades", - "propeller", - "families", - "tandem", - "according", - "blocks", - "design", "using", - "symmetry", - "important", + "creating", + "previous", "monodisperse", + "however", + "perfectly", + "experimentally", + "residues", + "case", + "strongly", "approach", - "also", - "stable", - "desired", + "blocks", + "proteins", + "size", "modular", + "tandem", + "architecture", + "highly", + "created", + "carrying", + "evolution", + "duplication", + "recreate", + "computational", + "consists", + "symmetry", + "design", + "propeller", + "fusion", + "simple", + "produce", "different", - "residues", - "played", - "two", + "also", + "180", + "failed", + "kda", "leading", "validated", - "creating", - "protein", - "previous", "identical", - "theory", - "computational", - "consists", - "case", "developed", + "desired", + "implies", + "blades", + "many", + "suitable", + "expressed", + "attempts", + "sixfold", + "structure", + "important", + "according", + "crystallography", + "42", + "intermediate", + "blade", + "assemble", "create", - "forms", - "new" + "consistent" ], "release_date":"2014-10-08", "publication":"\"Computational design of a self-assembling symmetrical beta-propeller protein\", Proc.Natl.Acad.Sci.USA, 111, 15102-15107", @@ -64595,43 +64669,43 @@ "sim":0.9606999755, "partner":"7zq2" }, + { + "sim":0.9721999764, + "partner":"6i3b" + }, { "sim":0.9524000287, "partner":"5f53" }, { - "sim":0.9592999816, - "partner":"4zcn" + "sim":0.9539999962, + "partner":"6f0s" }, { - "sim":0.9520999789, - "partner":"5i1z" + "sim":0.9715999961, + "partner":"3ww9" }, { "sim":0.9728999734, "partner":"6qsf" }, { - "sim":0.9721999764, - "partner":"6i3b" - }, - { - "sim":0.9715999961, - "partner":"3ww9" + "sim":0.9592999816, + "partner":"4zcn" }, { - "sim":0.9539999962, - "partner":"6f0s" + "sim":0.9520999789, + "partner":"5i1z" } ], "struct_thr_sim_natural":[ - { - "sim":0.9711999893, - "partner":"1rwl" - }, { "sim":0.975399971, "partner":"1rwi" + }, + { + "sim":0.9711999893, + "partner":"1rwl" } ], "seq_max_sim_designed":[ @@ -64705,94 +64779,94 @@ ], "subtitle":"Structure of the engineered retro-aldolase ra95.0", "tags":[ - "engineered enzyme", "de novo protein", "directed evolution", + "engineered enzyme", "retro-aldolase" ], "keywords":[ - "evolution", - "ordered", - "intermediate", - "many", - "studies", - "efficiencies", - "designed", - "favor", - "computationally", - "however", + "molecular", + "structural", + "mechanistically", + "promiscuous", + "new", + "residue", + "drive", + "protein", + "changes", + "unanticipated", + "catalytic", + "water", "alternative", - "molecule", - "approaching", - "abandoned", - "reactive", + "engineered", + "initial", + "characterized", + "however", + "mechanistic", "lysine", - "random", + "computationally", + "specific", + "apparatus", + "efficiencies", + "optimization", + "sites", "process", + "approaching", + "unexpectedly", "enzymes", - "characterized", - "variants", - "enzyme", - "suggests", - "competition", - "initial", - "evolutionary", - "often", - "innovation", - "drive", - "highlight", - "mechanistic", - "structures", "center", - "natural", - "evolved", - "created", - "early", - "molecular", - "functional", - "changes", - "catalytic", - "screening", - "artificial", - "optimization", "may", - "active", - "specific", + "enzyme", + "created", + "emergence", + "evolution", + "importance", + "favor", + "supporting", + "molecule", "advances", - "activity", + "mutagenesis", + "pocket", + "highlight", "design", - "apparatus", - "fueled", - "pronounced", - "mechanistically", - "structural", - "sites", + "active", + "suggests", + "natural", + "functional", + "abandoned", "consisting", - "promiscuous", - "importance", - "boosted", - "one", - "groups", - "unexpectedly", + "mobility", "also", - "directed", - "emergence", - "engineered", + "groups", + "boosted", + "reactive", + "screening", + "evolved", + "evolutionary", "reveal", - "unanticipated", + "designed", + "pronounced", + "directed", + "often", + "many", + "one", + "loop", + "variants", + "structures", + "competition", "primitive", - "affording", - "protein", - "residue", - "water", - "mobility", + "random", "silico", - "pocket", + "intermediate", "internal", - "loop", - "supporting", - "mutagenesis", - "new" + "artificial", + "activity", + "innovation", + "affording", + "early", + "fueled", + "studies", + "ordered" ], "release_date":"2012-11-07", "publication":"\"Evolution of a designed retro-aldolase leads to complete active site remodeling\", Nat.Chem.Biol., 9, 494-498", @@ -64891,11 +64965,11 @@ }, { "sim":446.0, - "partner":"1a53" + "partner":"1lbl" }, { "sim":446.0, - "partner":"1lbl" + "partner":"1a53" }, { "sim":446.0, @@ -65083,135 +65157,135 @@ ], "subtitle":"Ad5 knob in complex with a designed ankyrin repeat protein", "tags":[ - "viral protein\/de novo protein", - "darpin", "protein design", - "viral protein-de novo protein complex" + "viral protein\/de novo protein", + "viral protein-de novo protein complex", + "darpin" ], "keywords":[ - "many", - "clinical", - "gene", - "ablation", - "link", - "moiety", - "thus", - "use", - "modules", - "efficiencies", - "designed", - "receptor", - "choice", - "requires", - "contains", - "crystal", - "modeling", - "shp", - "epithelial", + "affinity", "trials", - "module", - "adapter", - "tumor", - "structure", - "repeat", + "engineering", + "kinetic", "escherichia", - "capsid", - "exceeding", - "serotype", - "affinity", + "epithelial", + "resolution", + "knob", + "repeat", + "three", "ad", - "like", - "even", - "interaction", + "moiety", + "rapidly", + "delivery", + "new", + "markers", + "transduction", + "various", + "protein", + "readily", + "tissue", "5", + "adenovirus", + "binding", + "fully", + "mediate", + "produced", + "site", + "manner", + "promise", "original", - "proteins", - "viral", + "ablation", + "two", + "crystal", + "computer", + "binds", + "10", "growth", - "remain", - "cell", + "using", + "vectors", + "receptor", + "choice", + "complex", "ads", - "manner", - "rapidly", - "efficient", - "epidermal", - "binds", - "fully", + "adapter", + "adhesion", + "payloads", + "ligand", + "gene", + "thus", + "enabled", + "specific", + "prefabricated", + "fused", + "efficiencies", + "stability", + "bound", + "modules", + "proteins", + "serotype", + "use", + "factor", + "ankyrin", + "tumor", + "contains", + "tropism", + "shp", + "like", + "surface", + "adapters", + "design", + "even", "fiber", - "comparable", - "trimeric", - "21", - "converted", "natural", - "three", + "different", + "consisting", "targeting", - "series", - "stability", - "tissue", + "transgene", + "clinical", "virus", - "phage", + "arrived", + "retargeted", + "exceeding", + "cell", + "shown", + "interaction", + "viral", + "varying", + "series", "coli", - "transduction", - "vectors", - "resolution", - "knob", + "types", + "requires", + "population", + "developed", + "modeling", "darpins", - "specificities", - "fused", - "10", - "prefabricated", - "shown", - "specific", - "adapters", - "engineering", - "design", - "produced", - "promise", - "using", - "clamp", - "extraordinary", - "surface", - "high", + "capsid", "could", - "mediate", - "kinetic", - "factor", - "consisting", - "ligand", - "delivery", + "designed", + "trimeric", + "efficient", "one", + "epidermal", + "clamp", + "many", + "extraordinary", + "specificities", + "link", + "solving", + "21", + "comparable", "efficiently", - "transgene", - "population", - "adenoviruses", - "human", - "tropism", - "adenovirus", - "different", - "ankyrin", - "lambdoid", - "two", - "markers", - "adhesion", - "uptake", - "binding", - "bound", - "protein", - "payloads", - "complex", - "retargeted", + "structure", + "module", "block", - "readily", - "various", - "solving", - "computer", - "arrived", - "varying", - "types", - "enabled", - "site", - "developed", - "new" + "phage", + "uptake", + "high", + "remain", + "lambdoid", + "converted", + "human", + "adenoviruses" ], "release_date":"2013-02-27", "publication":"\"Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters\", Proc. Natl. Acad. Sci. U.S.A., 110, E869-E877", @@ -65276,19 +65350,19 @@ }, { "sim":254.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":254.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":254.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":254.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":254.0, @@ -65296,35 +65370,35 @@ }, { "sim":254.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":254.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":254.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":254.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":254.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":254.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":254.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":254.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":252.0, @@ -65336,11 +65410,11 @@ }, { "sim":251.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":251.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":250.0, @@ -65472,7 +65546,7 @@ }, { "sim":218.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":218.0, @@ -65480,7 +65554,7 @@ }, { "sim":218.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":217.0, @@ -65508,11 +65582,11 @@ }, { "sim":211.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":211.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":211.0, @@ -65548,11 +65622,11 @@ }, { "sim":184.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":184.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":181.0, @@ -65575,13 +65649,17 @@ "partner":"8rci" }, { - "sim":169.0, - "partner":"4gpm" + "sim":173.0, + "partner":"9glq" }, { "sim":169.0, "partner":"4hb5" }, + { + "sim":169.0, + "partner":"4gpm" + }, { "sim":169.0, "partner":"4gmr" @@ -65670,11 +65748,11 @@ }, { "sim":229.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":229.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":197.0, @@ -65774,15 +65852,15 @@ }, { "sim":104.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":104.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":104.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":103.0, @@ -65998,23 +66076,23 @@ }, { "sim":71.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":71.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":70.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":70.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":70.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":70.0, @@ -66086,10 +66164,6 @@ } ], "struct_thr_sim_designed":[ - { - "sim":0.9595999718, - "partner":"8qlb" - }, { "sim":0.9684000015, "partner":"2qyj" @@ -66099,24 +66173,36 @@ "partner":"6c9k" }, { - "sim":0.9588999748, - "partner":"8ql2" + "sim":0.9520000219, + "partner":"8aed" }, { - "sim":0.956700027, - "partner":"8qea" + "sim":0.9566000104, + "partner":"7dne" }, { "sim":0.9538000226, "partner":"5oou" }, + { + "sim":0.9595999718, + "partner":"8qlb" + }, + { + "sim":0.9570000172, + "partner":"9f22" + }, + { + "sim":0.9588999748, + "partner":"8ql2" + }, { "sim":0.9562000036, "partner":"8ql5" }, { - "sim":0.9585000277, - "partner":"8ql3" + "sim":0.9557999969, + "partner":"8ql4" }, { "sim":0.9587000012, @@ -66127,40 +66213,32 @@ "partner":"8ql7" }, { - "sim":0.9581000209, - "partner":"8qla" + "sim":0.956700027, + "partner":"8qea" }, { - "sim":0.9557999969, - "partner":"8ql4" + "sim":0.954400003, + "partner":"7z7e" }, { - "sim":0.9566000104, - "partner":"7dne" + "sim":0.9585000277, + "partner":"8ql3" }, { "sim":0.9566000104, "partner":"8ql8" }, { - "sim":0.9539999962, - "partner":"8ql9" - }, - { - "sim":0.9520000219, - "partner":"8aed" - }, - { - "sim":0.9570000172, - "partner":"9f22" + "sim":0.9514999986, + "partner":"2bkg" }, { - "sim":0.954400003, - "partner":"7z7e" + "sim":0.9581000209, + "partner":"8qla" }, { - "sim":0.9514999986, - "partner":"2bkg" + "sim":0.9539999962, + "partner":"8ql9" } ], "struct_thr_sim_natural":[ @@ -66276,120 +66354,120 @@ ], "subtitle":"Crystal structure of computationally designed armadillo repeat proteins for modular peptide recognition", "tags":[ - "de novo protein\/peptide", - "de novo protein-peptide complex" + "de novo protein-peptide complex", + "de novo protein\/peptide" ], "keywords":[ - "independent", - "thus", - "low", - "selection", - "conserved", - "peptide", - "designed", - "mutations", - "flexibility", - "crystal", - "determined", - "target", - "obtain", - "deviated", - "arranged", - "basis", - "regions", - "bind", - "assembled", - "conformation", - "structure", + "repeats", + "yeast", + "molecular", + "accordingly", "repeat", - "computationally", - "building", - "molecule", + "experimental", + "three", + "extended", + "new", + "assembled", + "pockets", + "deviated", + "binding", + "pair", "armrps", - "darmrp", - "42", - "maintaining", - "proteins", - "demand", - "employed", + "expected", + "two", + "crystal", + "optimal", + "using", "similar", + "simulations", + "conformation", + "flexibility", + "computationally", + "armadillo", + "thus", + "identified", + "residues", + "specific", "although", - "remove", + "library", + "uniform", "elongated", + "bind", + "basis", + "approach", + "proteins", + "low", + "aa", + "modular", + "may", + "higher", + "nanomolar", + "analyzed", + "complementary", + "regions", + "peptide", + "maintaining", + "molecule", + "curvature", + "surface", + "design", + "onto", + "length", + "selection", + "stacked", "binders", - "darmrps", + "every", + "natural", + "different", + "consisting", + "insertion", + "independent", + "build", "symmetric", - "dynamics", - "onto", - "approximation", - "structures", - "nanomolar", + "resulted", + "arranged", + "series", "piece", - "natural", - "pockets", - "three", - "armadillo", + "building", + "system", + "sequence", + "whole", + "desired", + "remove", + "per", + "could", + "dynamics", + "obtain", + "explicit", + "designed", "form", - "first", - "solvent", - "accordingly", - "every", - "series", + "superhelical", + "employed", "generation", - "per", - "molecular", - "expected", - "thereby", - "whole", - "stackable", - "higher", + "conserved", "geometry", - "resulted", - "extended", - "may", - "optimal", - "specific", - "simulations", - "aa", - "stacked", - "design", - "avoid", + "mutations", + "structures", + "traditional", + "first", + "structure", + "thereby", + "determined", "recognize", - "using", - "insertion", - "surface", - "stabilized", - "sequence", - "repeats", - "variations", - "explicit", - "could", + "target", + "42", + "darmrps", + "silico", + "approximation", + "solvent", + "darmrp", "preselected", - "library", - "consisting", - "build", - "approach", - "length", - "analyzed", - "desired", - "experimental", - "modular", - "different", - "residues", + "demand", + "avoid", "affinities", - "two", - "complementary", - "identified", - "system", - "superhelical", - "uniform", - "curvature", - "silico", - "yeast", - "binding", - "pair", - "traditional", - "new" + "variations", + "stabilized", + "stackable" ], "release_date":"2016-01-13", "publication":"\"Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition\", J.Mol.Biol., 428, 4467", @@ -66426,11 +66504,11 @@ }, { "sim":437.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":437.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":412.0, @@ -66442,11 +66520,11 @@ }, { "sim":298.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":298.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":298.0, @@ -66458,11 +66536,11 @@ }, { "sim":298.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":298.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":293.0, @@ -66588,15 +66666,15 @@ }, { "sim":149.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":149.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":149.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":149.0, @@ -66618,10 +66696,6 @@ "sim":143.0, "partner":"4u54" }, - { - "sim":143.0, - "partner":"4u5o" - }, { "sim":143.0, "partner":"3ve6" @@ -66652,15 +66726,15 @@ }, { "sim":143.0, - "partner":"3l3q" + "partner":"4u5o" }, { "sim":143.0, - "partner":"3btr" + "partner":"3l3q" }, { "sim":143.0, - "partner":"1y2a" + "partner":"3btr" }, { "sim":143.0, @@ -66668,11 +66742,11 @@ }, { "sim":143.0, - "partner":"1ial" + "partner":"1y2a" }, { "sim":143.0, - "partner":"3zir" + "partner":"1ial" }, { "sim":143.0, @@ -66695,12 +66769,12 @@ "partner":"3ziq" }, { - "sim":142.0, - "partner":"1ee5" + "sim":143.0, + "partner":"3zir" }, { "sim":142.0, - "partner":"3q5u" + "partner":"1ee5" }, { "sim":142.0, @@ -66708,15 +66782,15 @@ }, { "sim":142.0, - "partner":"1ejl" + "partner":"4yi0" }, { "sim":142.0, - "partner":"4yi0" + "partner":"3knd" }, { "sim":142.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":142.0, @@ -66724,16 +66798,20 @@ }, { "sim":142.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":142.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":142.0, "partner":"1pjn" }, + { + "sim":142.0, + "partner":"3q5u" + }, { "sim":142.0, "partner":"4uaf" @@ -66750,10 +66828,6 @@ "sim":142.0, "partner":"4ba3" }, - { - "sim":142.0, - "partner":"4htv" - }, { "sim":142.0, "partner":"4mz5" @@ -66764,15 +66838,7 @@ }, { "sim":142.0, - "partner":"3rzx" - }, - { - "sim":142.0, - "partner":"5e6q" - }, - { - "sim":142.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":142.0, @@ -66806,6 +66872,18 @@ "sim":142.0, "partner":"3uvu" }, + { + "sim":142.0, + "partner":"3rzx" + }, + { + "sim":142.0, + "partner":"5e6q" + }, + { + "sim":142.0, + "partner":"3oqs" + }, { "sim":141.0, "partner":"3wpt" @@ -66840,15 +66918,15 @@ }, { "sim":140.0, - "partner":"4pvz" + "partner":"1bk5" }, { "sim":140.0, - "partner":"1bk5" + "partner":"1bk6" }, { "sim":140.0, - "partner":"1bk6" + "partner":"4pvz" }, { "sim":140.0, @@ -67003,116 +67081,116 @@ "armadillo repeat protein" ], "keywords":[ - "independent", - "thus", - "low", - "selection", - "conserved", - "peptide", - "designed", - "mutations", - "flexibility", - "crystal", - "determined", - "target", - "obtain", - "deviated", - "arranged", - "basis", - "regions", - "bind", - "assembled", - "conformation", - "structure", + "repeats", + "yeast", + "molecular", + "accordingly", "repeat", - "computationally", - "building", - "molecule", + "experimental", + "three", + "extended", + "new", + "assembled", + "pockets", + "deviated", + "binding", + "pair", "armrps", - "darmrp", - "42", - "maintaining", - "proteins", - "demand", - "employed", + "expected", + "two", + "crystal", + "optimal", + "using", "similar", + "simulations", + "conformation", + "flexibility", + "computationally", + "armadillo", + "thus", + "identified", + "residues", + "specific", "although", - "remove", + "library", + "uniform", "elongated", + "bind", + "basis", + "approach", + "proteins", + "low", + "aa", + "modular", + "may", + "higher", + "nanomolar", + "analyzed", + "complementary", + "regions", + "peptide", + "maintaining", + "molecule", + "curvature", + "surface", + "design", + "onto", + "length", + "selection", + "stacked", "binders", - "darmrps", + "every", + "natural", + "different", + "consisting", + "insertion", + "independent", + "build", "symmetric", - "dynamics", - "onto", - "approximation", - "structures", - "nanomolar", + "resulted", + "arranged", + "series", "piece", - "natural", - "pockets", - "three", - "armadillo", + "building", + "system", + "sequence", + "whole", + "desired", + "remove", + "per", + "could", + "dynamics", + "obtain", + "explicit", + "designed", "form", - "first", - "solvent", - "accordingly", - "every", - "series", + "superhelical", + "employed", "generation", - "per", - "molecular", - "expected", - "thereby", - "whole", - "stackable", - "higher", + "conserved", "geometry", - "resulted", - "extended", - "may", - "optimal", - "specific", - "simulations", - "aa", - "stacked", - "design", - "avoid", + "mutations", + "structures", + "traditional", + "first", + "structure", + "thereby", + "determined", "recognize", - "using", - "insertion", - "surface", - "stabilized", - "sequence", - "repeats", - "variations", - "explicit", - "could", + "target", + "42", + "darmrps", + "silico", + "approximation", + "solvent", + "darmrp", "preselected", - "library", - "consisting", - "build", - "approach", - "length", - "analyzed", - "desired", - "experimental", - "modular", - "different", - "residues", + "demand", + "avoid", "affinities", - "two", - "complementary", - "identified", - "system", - "superhelical", - "uniform", - "curvature", - "silico", - "yeast", - "binding", - "pair", - "traditional", - "new" + "variations", + "stabilized", + "stackable" ], "release_date":"2016-01-13", "publication":"\"Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition\", J.Mol.Biol., 428, 4467", @@ -67157,11 +67235,11 @@ }, { "sim":398.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":398.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":273.0, @@ -67177,11 +67255,11 @@ }, { "sim":259.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":259.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":259.0, @@ -67193,11 +67271,11 @@ }, { "sim":259.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":259.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":257.0, @@ -67205,11 +67283,11 @@ }, { "sim":254.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":254.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":254.0, @@ -67311,15 +67389,15 @@ }, { "sim":136.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":136.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":136.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":136.0, @@ -67341,10 +67419,6 @@ "sim":128.0, "partner":"4u54" }, - { - "sim":128.0, - "partner":"4u5o" - }, { "sim":128.0, "partner":"3ve6" @@ -67375,15 +67449,15 @@ }, { "sim":128.0, - "partner":"3l3q" + "partner":"4u5o" }, { "sim":128.0, - "partner":"3btr" + "partner":"3l3q" }, { "sim":128.0, - "partner":"1y2a" + "partner":"3btr" }, { "sim":128.0, @@ -67391,11 +67465,11 @@ }, { "sim":128.0, - "partner":"1ial" + "partner":"1y2a" }, { "sim":128.0, - "partner":"3zir" + "partner":"1ial" }, { "sim":128.0, @@ -67417,6 +67491,10 @@ "sim":128.0, "partner":"3ziq" }, + { + "sim":128.0, + "partner":"3zir" + }, { "sim":127.0, "partner":"1ee4" @@ -67427,27 +67505,27 @@ }, { "sim":127.0, - "partner":"3q5u" + "partner":"4oih" }, { "sim":127.0, - "partner":"4oih" + "partner":"4yi0" }, { "sim":127.0, - "partner":"1ejl" + "partner":"3knd" }, { "sim":127.0, - "partner":"4yi0" + "partner":"1ejl" }, { "sim":127.0, - "partner":"3knd" + "partner":"1ejy" }, { "sim":127.0, - "partner":"1ejy" + "partner":"1pjm" }, { "sim":127.0, @@ -67455,11 +67533,11 @@ }, { "sim":127.0, - "partner":"1pjm" + "partner":"1pjn" }, { "sim":127.0, - "partner":"1pjn" + "partner":"3q5u" }, { "sim":127.0, @@ -67477,10 +67555,6 @@ "sim":127.0, "partner":"4ba3" }, - { - "sim":127.0, - "partner":"4htv" - }, { "sim":127.0, "partner":"4mz5" @@ -67491,15 +67565,7 @@ }, { "sim":127.0, - "partner":"3rzx" - }, - { - "sim":127.0, - "partner":"5e6q" - }, - { - "sim":127.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":127.0, @@ -67533,6 +67599,18 @@ "sim":127.0, "partner":"3uvu" }, + { + "sim":127.0, + "partner":"3rzx" + }, + { + "sim":127.0, + "partner":"5e6q" + }, + { + "sim":127.0, + "partner":"3oqs" + }, { "sim":126.0, "partner":"1bk5" @@ -67675,90 +67753,90 @@ ], "subtitle":"Crystal structure of symfoil-4p\/pv2: de novo designed beta-trefoil architecture with symmetric primary structure, primitive version 2 (6xleu \/ pv1)", "tags":[ + "symfoil", + "de novo protein", "symmetric", - "pre-biotic", "beta-trefoil", - "de novo protein", - "symfoil" + "pre-biotic" ], "keywords":[ - "pi", - "require", + "whether", + "concentrations", + "show", + "information", + "question", + "80", + "13", + "comprise", + "biosynthetic", + "within", "results", - "abiogenesis", - "suggest", + "unsolved", + "characteristic", + "folding", + "protein", + "deconstruction", + "salt", + "produced", + "essential", + "polypeptides", + "two", + "pi", + "10", "questions", + "abiotic", + "resource", + "defines", + "compendium", + "overall", "regarding", - "pathways", - "show", - "proteogenesis", - "approaching", - "concentrations", "proteins", - "syntheses", "process", - "biosynthetic", - "whether", - "alphabet", - "resulting", - "symmetric", - "resource", - "permit", - "essential", "size", - "exhibit", - "cooperatively", + "approaching", "consensus", - "properties", - "investigate", - "versions", - "salt", - "compendium", - "amino", + "suggest", + "contain", + "emergence", "chemical", + "pathways", "substantial", - "abiotic", - "acids", - "information", - "10", - "80", + "investigate", + "set", "12", - "produced", - "reduced", - "deconstruction", - "cooperative", - "defines", - "high", - "unsolved", + "exhibit", + "halophile", "extant", - "identifies", + "different", + "environment", + "properties", + "fold", + "amino", + "reduced", + "symmetric", "formation", - "comprise", - "characteristic", - "13", + "permit", "plausible", + "alphabet", + "types", + "versions", + "cooperative", + "cooperatively", + "require", + "acidification", "prebiotic", - "question", + "syntheses", "might", - "overall", - "acidification", - "halophile", - "fold", - "sufficient", - "percentage", - "emergence", - "different", - "two", + "resulting", + "abiogenesis", "primitive", - "set", - "protein", + "high", + "proteogenesis", + "acids", + "sufficient", + "identifies", "foldable", - "types", - "environment", - "within", - "polypeptides", - "folding", - "contain" + "percentage" ], "release_date":"2013-01-16", "publication":"\"Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein\", Proc.Natl.Acad.Sci.USA, 110, 2135-2139", @@ -67889,28 +67967,12 @@ }, { "sim":85.0, - "partner":"3ba7" - }, - { - "sim":85.0, - "partner":"3fj8" - }, - { - "sim":85.0, - "partner":"1rg8" - }, - { - "sim":85.0, - "partner":"3baq" + "partner":"3fj9" }, { "sim":85.0, "partner":"1jt7" }, - { - "sim":85.0, - "partner":"3fj9" - }, { "sim":85.0, "partner":"3fja" @@ -67963,13 +68025,21 @@ "sim":85.0, "partner":"3crg" }, + { + "sim":85.0, + "partner":"3crh" + }, { "sim":85.0, "partner":"1jy0" }, { "sim":85.0, - "partner":"3crh" + "partner":"3ba4" + }, + { + "sim":85.0, + "partner":"3cri" }, { "sim":85.0, @@ -67977,15 +68047,23 @@ }, { "sim":85.0, - "partner":"3ba4" + "partner":"1jqz" }, { "sim":85.0, - "partner":"3cri" + "partner":"3ba7" }, { "sim":85.0, - "partner":"1jqz" + "partner":"3fj8" + }, + { + "sim":85.0, + "partner":"1rg8" + }, + { + "sim":85.0, + "partner":"3baq" }, { "sim":84.0, @@ -68005,11 +68083,11 @@ }, { "sim":84.0, - "partner":"1jtc" + "partner":"3fjd" }, { "sim":84.0, - "partner":"3fjd" + "partner":"1jtc" }, { "sim":84.0, @@ -68131,10 +68209,6 @@ "sim":78.0, "partner":"3cu1" }, - { - "sim":78.0, - "partner":"2k8r" - }, { "sim":78.0, "partner":"2ki6" @@ -68151,6 +68225,10 @@ "sim":78.0, "partner":"2ki4" }, + { + "sim":78.0, + "partner":"2k8r" + }, { "sim":78.0, "partner":"1evt" @@ -68365,111 +68443,111 @@ ], "subtitle":"Crystal structure of computationally designed protein p6d", "tags":[ - "acylated n-terminus", - "three-helix bundle", - "computational protein design", + "de novo design", + "alpha-helix", "coiled-coil protein", - "computationally designed protein", "de novo protein", - "synthetic", - "alpha-helix", "three helix coiled coil", - "de novo design" + "synthetic", + "computationally designed protein", + "computational protein design", + "acylated n-terminus", + "three-helix bundle" ], "keywords":[ - "minima", - "macroscopic", - "analysis", - "predetermined", - "channels", - "herein", + "molecular", + "structural", + "development", + "resolution", "candidate", - "designed", - "programmed", - "dimensions", - "experimentally", - "crystal", - "potential", - "hexameric", - "ii", - "sequences", - "interactions", - "designing", - "structure", - "therapeutic", - "consistent", - "characterizing", - "modification", - "proteins", - "presented", - "de", - "\u00e5", - "atoms", - "square", - "highly", - "targeted", - "materials", - "often", - "structures", - "positions", - "natural", - "complexity", + "group", + "precision", "three", - "involves", - "biology", - "designable", - "form", - "facilitate", - "crystallization", - "molecular", + "deviation", + "mean", "exhibits", - "group", - "resolution", + "span", + "root", + "model", + "protein", + "positions", + "given", + "novo", "catalytic", - "identify", - "engineer", - "landscape", - "iii", - "agreement", + "applications", + "crystal", + "creating", + "complex", "nanoscale", - "provides", - "design", "govern", - "model", - "crystallographic", - "applications", + "efforts", + "agreement", + "experimentally", + "consistent", + "polar", + "designable", + "approach", + "proteins", + "iii", + "highly", + "minima", + "ensemble", + "square", + "computational", + "p6", + "facilitate", + "hexameric", + "designing", "symmetry", + "design", "energy", - "root", - "ensemble", - "structural", - "layered", + "subtle", + "provides", "nanostructured", + "biology", + "natural", + "potential", + "atoms", + "therapeutic", + "complexity", + "macroscopic", + "backbone", "noncovalent", - "one", - "subtle", - "approach", - "novo", - "efforts", - "deviation", - "precision", - "p6", - "creating", + "channels", + "landscape", + "crystals", + "predetermined", + "materials", + "crystallographic", + "engineer", + "designed", + "form", + "crystalline", "central", - "polar", - "span", - "protein", - "yield", - "given", - "complex", - "backbone", + "rmsd", + "analysis", + "often", + "dimensions", + "involves", + "sequences", + "modification", "space", - "development", - "mean", - "computational", - "crystalline", - "crystals", - "rmsd" + "one", + "targeted", + "structures", + "de", + "\u00e5", + "crystallization", + "structure", + "herein", + "interactions", + "yield", + "programmed", + "presented", + "identify", + "characterizing", + "layered", + "ii" ], "release_date":"2012-05-02", "publication":"\"Computational design of a protein crystal\", Proc.Natl.Acad.Sci.USA, 109, 7304-7309", @@ -68583,104 +68661,104 @@ ], "subtitle":"Designed armadillo repeat protein (yiiim3aii)", "tags":[ - "armadillo repeat motif", "de novo protein", + "armadillo repeat motif", "solenoid repeat" ], "keywords":[ - "domain", - "analysis", - "monomeric", - "prevented", - "frequently", - "systematically", - "scaffolds", - "peptide", - "continuation", - "designed", - "stabilities", - "mutations", - "provide", - "improved", - "crystal", - "determined", - "obtain", - "show", - "based", - "basis", - "regions", - "interactions", - "best", - "repeating", - "repeat", + "templates", + "repeats", + "recognition", "redesign", - "however", - "combinations", + "optimized", + "structural", + "repeat", + "show", + "well", + "intrinsically", + "three", + "diffracting", + "extended", + "binding", + "showed", + "thermodynamic", + "subsequent", "armrps", "composed", - "excellent", - "proteins", - "redesigned", - "investigated", + "two", + "crystal", + "stable", + "caused", "involved", - "\u00e5", - "6", - "point", - "serve", - "recognition", - "initial", + "conclude", "occurring", - "units", - "structures", - "naturally", - "templates", - "three", - "caused", - "showed", + "stabilities", + "initial", + "however", + "respectively", "armadillo", - "compared", - "sequential", - "intrinsically", + "basis", "stability", - "prevent", - "cap", - "subsequent", - "respectively", - "mentioned", - "extended", - "ranging", + "proteins", + "units", + "modular", + "continuation", + "swapping", "four", - "thermodynamic", - "artificial", - "9", - "swap", "introduced", - "design", "required", - "high", - "repeats", - "caps", - "structural", - "conclude", - "designs", - "analyses", - "optimized", - "stable", - "modular", - "well", + "regions", + "peptide", + "best", + "design", + "compared", + "redesigned", + "cap", + "combinations", + "domain", "different", - "two", - "events", - "binding", - "synthesized", + "prevent", + "point", + "9", + "improved", + "sequential", + "resolutions", + "excellent", + "crystals", "identical", + "analyses", "refined", - "resolutions", - "diffracting", - "internal", - "swapping", + "obtain", + "designed", + "analysis", + "events", + "naturally", + "repeating", + "6", + "investigated", + "mutations", + "structures", + "ranging", + "synthesized", + "based", + "\u00e5", + "monomeric", + "caps", + "scaffolds", + "provide", + "determined", + "serve", + "frequently", + "interactions", "biophysical", - "crystals" + "prevented", + "internal", + "artificial", + "mentioned", + "high", + "designs", + "swap", + "systematically" ], "release_date":"2012-05-16", "publication":"\"Structure-based optimization of designed Armadillo-repeat proteins\", Protein Sci., 21, 1015-1028", @@ -68733,11 +68811,11 @@ }, { "sim":348.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":348.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":348.0, @@ -68749,11 +68827,11 @@ }, { "sim":348.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":348.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":348.0, @@ -68813,11 +68891,11 @@ }, { "sim":247.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":247.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":244.0, @@ -68923,7 +69001,7 @@ }, { "sim":135.0, - "partner":"3q5u" + "partner":"3knd" }, { "sim":135.0, @@ -68931,11 +69009,11 @@ }, { "sim":135.0, - "partner":"3knd" + "partner":"1ejy" }, { "sim":135.0, - "partner":"1ejy" + "partner":"1pjm" }, { "sim":135.0, @@ -68943,11 +69021,11 @@ }, { "sim":135.0, - "partner":"1pjm" + "partner":"1pjn" }, { "sim":135.0, - "partner":"1pjn" + "partner":"3q5u" }, { "sim":135.0, @@ -68959,15 +69037,15 @@ }, { "sim":135.0, - "partner":"3rzx" + "partner":"3rz9" }, { "sim":135.0, - "partner":"3oqs" + "partner":"3rzx" }, { "sim":135.0, - "partner":"3rz9" + "partner":"3oqs" }, { "sim":132.0, @@ -69092,99 +69170,99 @@ "solenoid repeat" ], "keywords":[ - "domain", - "analysis", - "monomeric", - "prevented", - "frequently", - "systematically", - "scaffolds", - "peptide", - "continuation", - "designed", - "stabilities", - "mutations", - "provide", - "improved", - "crystal", - "determined", - "obtain", - "show", - "based", - "basis", - "regions", - "interactions", - "best", - "repeating", - "repeat", + "templates", + "repeats", + "recognition", "redesign", - "however", - "combinations", + "optimized", + "structural", + "repeat", + "show", + "well", + "intrinsically", + "three", + "diffracting", + "extended", + "binding", + "showed", + "thermodynamic", + "subsequent", "armrps", "composed", - "excellent", - "proteins", - "redesigned", - "investigated", + "two", + "crystal", + "stable", + "caused", "involved", - "\u00e5", - "6", - "point", - "serve", - "recognition", - "initial", + "conclude", "occurring", - "units", - "structures", - "naturally", - "templates", - "three", - "caused", - "showed", + "stabilities", + "initial", + "however", + "respectively", "armadillo", - "compared", - "sequential", - "intrinsically", + "basis", "stability", - "prevent", - "cap", - "subsequent", - "respectively", - "mentioned", - "extended", - "ranging", + "proteins", + "units", + "modular", + "continuation", + "swapping", "four", - "thermodynamic", - "artificial", - "9", - "swap", "introduced", - "design", "required", - "high", - "repeats", - "caps", - "structural", - "conclude", - "designs", - "analyses", - "optimized", - "stable", - "modular", - "well", + "regions", + "peptide", + "best", + "design", + "compared", + "redesigned", + "cap", + "combinations", + "domain", "different", - "two", - "events", - "binding", - "synthesized", + "prevent", + "point", + "9", + "improved", + "sequential", + "resolutions", + "excellent", + "crystals", "identical", + "analyses", "refined", - "resolutions", - "diffracting", - "internal", - "swapping", + "obtain", + "designed", + "analysis", + "events", + "naturally", + "repeating", + "6", + "investigated", + "mutations", + "structures", + "ranging", + "synthesized", + "based", + "\u00e5", + "monomeric", + "caps", + "scaffolds", + "provide", + "determined", + "serve", + "frequently", + "interactions", "biophysical", - "crystals" + "prevented", + "internal", + "artificial", + "mentioned", + "high", + "designs", + "swap", + "systematically" ], "release_date":"2012-05-16", "publication":"\"Structure-based optimization of designed Armadillo-repeat proteins\", Protein Sci., 21, 1015-1028", @@ -69221,11 +69299,11 @@ }, { "sim":413.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":413.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":413.0, @@ -69237,11 +69315,11 @@ }, { "sim":413.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":413.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":413.0, @@ -69269,11 +69347,11 @@ }, { "sim":402.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":402.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":399.0, @@ -69325,11 +69403,11 @@ }, { "sim":291.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":291.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":270.0, @@ -69427,7 +69505,7 @@ }, { "sim":154.0, - "partner":"3q5u" + "partner":"3knd" }, { "sim":154.0, @@ -69435,11 +69513,11 @@ }, { "sim":154.0, - "partner":"3knd" + "partner":"1ejy" }, { "sim":154.0, - "partner":"1ejy" + "partner":"1pjm" }, { "sim":154.0, @@ -69447,11 +69525,11 @@ }, { "sim":154.0, - "partner":"1pjm" + "partner":"1pjn" }, { "sim":154.0, - "partner":"1pjn" + "partner":"3q5u" }, { "sim":154.0, @@ -69463,15 +69541,15 @@ }, { "sim":154.0, - "partner":"3rzx" + "partner":"3rz9" }, { "sim":154.0, - "partner":"3oqs" + "partner":"3rzx" }, { "sim":154.0, - "partner":"3rz9" + "partner":"3oqs" }, { "sim":153.0, @@ -69556,104 +69634,104 @@ ], "subtitle":"Designed armadillo repeat protein (yiiim3aiii)", "tags":[ - "armadillo repeat motif", "de novo protein", + "armadillo repeat motif", "solenoid repeat" ], "keywords":[ - "domain", - "analysis", - "monomeric", - "prevented", - "frequently", - "systematically", - "scaffolds", - "peptide", - "continuation", - "designed", - "stabilities", - "mutations", - "provide", - "improved", - "crystal", - "determined", - "obtain", - "show", - "based", - "basis", - "regions", - "interactions", - "best", - "repeating", - "repeat", + "templates", + "repeats", + "recognition", "redesign", - "however", - "combinations", + "optimized", + "structural", + "repeat", + "show", + "well", + "intrinsically", + "three", + "diffracting", + "extended", + "binding", + "showed", + "thermodynamic", + "subsequent", "armrps", "composed", - "excellent", - "proteins", - "redesigned", - "investigated", + "two", + "crystal", + "stable", + "caused", "involved", - "\u00e5", - "6", - "point", - "serve", - "recognition", - "initial", + "conclude", "occurring", - "units", - "structures", - "naturally", - "templates", - "three", - "caused", - "showed", + "stabilities", + "initial", + "however", + "respectively", "armadillo", - "compared", - "sequential", - "intrinsically", + "basis", "stability", - "prevent", - "cap", - "subsequent", - "respectively", - "mentioned", - "extended", - "ranging", + "proteins", + "units", + "modular", + "continuation", + "swapping", "four", - "thermodynamic", - "artificial", - "9", - "swap", "introduced", - "design", "required", - "high", - "repeats", - "caps", - "structural", - "conclude", - "designs", - "analyses", - "optimized", - "stable", - "modular", - "well", + "regions", + "peptide", + "best", + "design", + "compared", + "redesigned", + "cap", + "combinations", + "domain", "different", - "two", - "events", - "binding", - "synthesized", + "prevent", + "point", + "9", + "improved", + "sequential", + "resolutions", + "excellent", + "crystals", "identical", + "analyses", "refined", - "resolutions", - "diffracting", - "internal", - "swapping", + "obtain", + "designed", + "analysis", + "events", + "naturally", + "repeating", + "6", + "investigated", + "mutations", + "structures", + "ranging", + "synthesized", + "based", + "\u00e5", + "monomeric", + "caps", + "scaffolds", + "provide", + "determined", + "serve", + "frequently", + "interactions", "biophysical", - "crystals" + "prevented", + "internal", + "artificial", + "mentioned", + "high", + "designs", + "swap", + "systematically" ], "release_date":"2012-05-16", "publication":"\"Structure-based optimization of designed Armadillo-repeat proteins\", Protein Sci., 21, 1015-1028", @@ -69706,11 +69784,11 @@ }, { "sim":344.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":344.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":344.0, @@ -69722,11 +69800,11 @@ }, { "sim":344.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":344.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":343.0, @@ -69786,11 +69864,11 @@ }, { "sim":251.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":251.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":242.0, @@ -69896,7 +69974,7 @@ }, { "sim":123.0, - "partner":"3q5u" + "partner":"3knd" }, { "sim":123.0, @@ -69904,11 +69982,11 @@ }, { "sim":123.0, - "partner":"3knd" + "partner":"1ejy" }, { "sim":123.0, - "partner":"1ejy" + "partner":"1pjm" }, { "sim":123.0, @@ -69916,11 +69994,11 @@ }, { "sim":123.0, - "partner":"1pjm" + "partner":"1pjn" }, { "sim":123.0, - "partner":"1pjn" + "partner":"3q5u" }, { "sim":123.0, @@ -69932,15 +70010,15 @@ }, { "sim":123.0, - "partner":"3rzx" + "partner":"3rz9" }, { "sim":123.0, - "partner":"3oqs" + "partner":"3rzx" }, { "sim":123.0, - "partner":"3rz9" + "partner":"3oqs" }, { "sim":122.0, @@ -70028,104 +70106,104 @@ ], "subtitle":"Designed armadillo repeat protein (yiim3aii)", "tags":[ - "armadillo repeat motif", "de novo protein", + "armadillo repeat motif", "solenoid repeat" ], "keywords":[ - "domain", - "analysis", - "monomeric", - "prevented", - "frequently", - "systematically", - "scaffolds", - "peptide", - "continuation", - "designed", - "stabilities", - "mutations", - "provide", - "improved", - "crystal", - "determined", - "obtain", - "show", - "based", - "basis", - "regions", - "interactions", - "best", - "repeating", - "repeat", + "templates", + "repeats", + "recognition", "redesign", - "however", - "combinations", + "optimized", + "structural", + "repeat", + "show", + "well", + "intrinsically", + "three", + "diffracting", + "extended", + "binding", + "showed", + "thermodynamic", + "subsequent", "armrps", "composed", - "excellent", - "proteins", - "redesigned", - "investigated", + "two", + "crystal", + "stable", + "caused", "involved", - "\u00e5", - "6", - "point", - "serve", - "recognition", - "initial", + "conclude", "occurring", - "units", - "structures", - "naturally", - "templates", - "three", - "caused", - "showed", + "stabilities", + "initial", + "however", + "respectively", "armadillo", - "compared", - "sequential", - "intrinsically", + "basis", "stability", - "prevent", - "cap", - "subsequent", - "respectively", - "mentioned", - "extended", - "ranging", + "proteins", + "units", + "modular", + "continuation", + "swapping", "four", - "thermodynamic", - "artificial", - "9", - "swap", "introduced", - "design", "required", - "high", - "repeats", - "caps", - "structural", - "conclude", - "designs", - "analyses", - "optimized", - "stable", - "modular", - "well", + "regions", + "peptide", + "best", + "design", + "compared", + "redesigned", + "cap", + "combinations", + "domain", "different", - "two", - "events", - "binding", - "synthesized", + "prevent", + "point", + "9", + "improved", + "sequential", + "resolutions", + "excellent", + "crystals", "identical", + "analyses", "refined", - "resolutions", - "diffracting", - "internal", - "swapping", + "obtain", + "designed", + "analysis", + "events", + "naturally", + "repeating", + "6", + "investigated", + "mutations", + "structures", + "ranging", + "synthesized", + "based", + "\u00e5", + "monomeric", + "caps", + "scaffolds", + "provide", + "determined", + "serve", + "frequently", + "interactions", "biophysical", - "crystals" + "prevented", + "internal", + "artificial", + "mentioned", + "high", + "designs", + "swap", + "systematically" ], "release_date":"2012-05-16", "publication":"\"Structure-based optimization of designed Armadillo-repeat proteins\", Protein Sci., 21, 1015-1028", @@ -70178,11 +70256,11 @@ }, { "sim":329.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":329.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":329.0, @@ -70194,11 +70272,11 @@ }, { "sim":329.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":329.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":329.0, @@ -70214,11 +70292,11 @@ }, { "sim":328.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":328.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":326.0, @@ -70258,11 +70336,11 @@ }, { "sim":227.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":227.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":224.0, @@ -70368,7 +70446,7 @@ }, { "sim":128.0, - "partner":"3q5u" + "partner":"3knd" }, { "sim":128.0, @@ -70376,11 +70454,11 @@ }, { "sim":128.0, - "partner":"3knd" + "partner":"1ejy" }, { "sim":128.0, - "partner":"1ejy" + "partner":"1pjm" }, { "sim":128.0, @@ -70388,11 +70466,11 @@ }, { "sim":128.0, - "partner":"1pjm" + "partner":"1pjn" }, { "sim":128.0, - "partner":"1pjn" + "partner":"3q5u" }, { "sim":128.0, @@ -70404,15 +70482,15 @@ }, { "sim":128.0, - "partner":"3rzx" + "partner":"3rz9" }, { "sim":128.0, - "partner":"3oqs" + "partner":"3rzx" }, { "sim":128.0, - "partner":"3rz9" + "partner":"3oqs" }, { "sim":126.0, @@ -70530,98 +70608,98 @@ ], "subtitle":"Three dimensional structure of de novo designed serine hydrolase osh26, northeast structural genomics consortium (nesg) target or89", "tags":[ + "nesg", + "de novo protein", "northeast structural genomics consortium", "structural genomics", - "de novo protein", - "nesg", "psi-biology" ], "keywords":[ - "fluorophosphate", - "many", - "multiple", - "must", - "suggest", - "idealized", - "challenge", - "including", - "provide", - "triads", - "crystal", + "triad", "limited", + "yeast", + "optimized", "show", - "basis", + "single", + "multiple", + "idealized", + "simultaneously", "assess", - "display", + "nucleophilicity", + "residue", + "new", + "probes", + "hydrolases", + "product", + "binding", + "focus", + "following", + "stabilization", + "initiates", + "extensive", + "site", "networks", - "catalysis", - "rates", - "proteins", - "models", - "enzymes", + "demonstrate", + "systems", + "catalytic", + "crystal", + "using", "reactivity", - "focus", - "absolute", - "substrate", - "bonding", - "comparable", - "structures", + "agreement", + "react", + "biological", + "residues", "capture", - "natural", - "organophosphate", - "native", "transition", - "extensive", - "simultaneously", - "systems", - "hydrogen", - "triad", - "properties", - "following", - "diisopropyl", - "directly", - "serine", "release", - "catalytic", - "class", + "organophosphate", "optimization", + "basis", + "bound", + "proteins", + "enzymes", + "hydrogen", + "activation", + "suggest", + "absolute", + "unprecedented", + "computational", + "rates", + "serine", + "including", + "bonding", + "property", + "mutagenesis", + "agents", + "design", + "critical", + "must", "active", + "natural", + "substrate", + "display", + "properties", + "experiments", "successful", - "agreement", - "activity", - "design", + "quartet", + "diisopropyl", "nucleophile", - "using", - "agents", - "initiates", - "biological", - "property", + "catalysis", "could", - "stabilization", - "demonstrate", - "designs", - "nucleophilicity", - "critical", - "optimized", - "single", - "unprecedented", - "product", - "experiments", - "residues", - "react", + "directly", + "fluorophosphate", + "models", + "many", + "structures", + "comparable", + "provide", "state", - "hydrolases", - "quartet", - "bound", - "residue", - "binding", - "computational", - "yeast", - "activation", - "site", - "probes", - "mutagenesis", - "new" + "class", + "activity", + "native", + "triads", + "challenge", + "designs" ], "release_date":"2012-04-18", "publication":"\"Design of activated serine-containing catalytic triads with atomic-level accuracy\", Nat.Chem.Biol., 10, 386-391", @@ -70655,14 +70733,6 @@ ], "seq_thr_sim_natural":[ - { - "sim":707.0, - "partner":"1nzo" - }, - { - "sim":707.0, - "partner":"1z6f" - }, { "sim":707.0, "partner":"1nzu" @@ -70688,8 +70758,12 @@ "partner":"3mzf" }, { - "sim":705.0, - "partner":"1hd8" + "sim":707.0, + "partner":"1nzo" + }, + { + "sim":707.0, + "partner":"1z6f" }, { "sim":705.0, @@ -70697,11 +70771,11 @@ }, { "sim":705.0, - "partner":"1nj4" + "partner":"1hd8" }, { - "sim":444.0, - "partner":"3itb" + "sim":705.0, + "partner":"1nj4" }, { "sim":444.0, @@ -70711,6 +70785,10 @@ "sim":444.0, "partner":"3ita" }, + { + "sim":444.0, + "partner":"3itb" + }, { "sim":353.0, "partner":"3a3j" @@ -70775,7 +70853,7 @@ ], "seq_max_sim_natural":{ "sim":707.0, - "partner":"1nzo" + "partner":"1nzu" }, "struct_max_sim_designed":{ "sim":0.3125999868, @@ -70849,12 +70927,12 @@ ], "subtitle":"Darpin d1 binding to tubulin beta chain (not in complex)", "tags":[ - "tubulin beta chain", - "tubulin", "beta-tubulin", - "artificial ankyrin repeat proteins", + "darpin", "de novo protein", - "darpin" + "tubulin beta chain", + "artificial ankyrin repeat proteins", + "tubulin" ], "keywords":[ "description", @@ -70891,51 +70969,51 @@ "seq_thr_sim_designed":[ { "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":342.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":342.0, - "partner":"8ql9" + "partner":"8ql6" }, { "sim":342.0, - "partner":"8ql8" + "partner":"8qla" }, { "sim":342.0, - "partner":"8ql3" + "partner":"8ql8" }, { "sim":342.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":342.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":342.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":342.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":342.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":342.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":342.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":298.0, @@ -70951,19 +71029,19 @@ }, { "sim":295.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":295.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":291.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":291.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":290.0, @@ -71019,11 +71097,11 @@ }, { "sim":261.0, - "partner":"7z72" + "partner":"7z7e" }, { "sim":261.0, - "partner":"7z7e" + "partner":"7z72" }, { "sim":259.0, @@ -71091,7 +71169,7 @@ }, { "sim":253.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":253.0, @@ -71099,7 +71177,7 @@ }, { "sim":253.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":252.0, @@ -71155,11 +71233,11 @@ }, { "sim":223.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":223.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":223.0, @@ -71183,11 +71261,11 @@ }, { "sim":207.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":207.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":205.0, @@ -71199,19 +71277,23 @@ }, { "sim":198.0, - "partner":"8rci" + "partner":"7z73" }, { "sim":198.0, - "partner":"7z73" + "partner":"8rci" }, { "sim":192.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":192.0, - "partner":"4qfv" + "partner":"4o60" + }, + { + "sim":187.0, + "partner":"9glq" }, { "sim":178.0, @@ -71317,11 +71399,11 @@ }, { "sim":244.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":244.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":233.0, @@ -71425,15 +71507,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":100.0, @@ -71481,15 +71563,15 @@ }, { "sim":91.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":91.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":91.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":90.0, @@ -71637,11 +71719,11 @@ }, { "sim":74.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":74.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":73.0, @@ -71673,15 +71755,15 @@ }, { "sim":68.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":68.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":68.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":61.0, @@ -71751,7 +71833,7 @@ ], "seq_max_sim_designed":{ "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, "seq_max_sim_natural":{ "sim":342.0, @@ -71846,118 +71928,118 @@ "de novo protein" ], "keywords":[ - "analysis", + "engineering", + "defined", + "redesign", + "adopt", + "structural", + "key", "background", - "available", - "specificity", - "use", - "crystallography", - "peptide", - "designed", - "directing", - "dimeric", - "mutation", - "parallel", - "experimentally", + "endeavors", + "ideally", + "integrity", + "protein", + "controlling", + "positions", + "tetrameric", + "confirmed", + "novo", + "systems", + "applications", + "establish", "crystal", - "determined", - "potential", "referred", - "based", - "sequences", - "basis", - "synthetic", - "interactions", - "adopt", - "kept", - "structure", - "establish", - "redesign", - "database", - "oligomer", "later", - "however", - "maintaining", - "intriguingly", - "process", - "de", - "integrity", "characterized", - "toolkits", - "feature", - "specify", - "used", - "highly", - "targeted", - "exchanged", - "relationships", - "controlling", - "pcomp", - "trimeric", - "foreground", - "structures", - "empirical", - "positions", + "however", + "specificity", "predictable", + "dimer", + "experimentally", + "hitherto", "widely", - "solution", - "specification", - "function", - "give", - "particular", - "assembly", - "biology", + "basis", + "stability", + "foreground", + "intriguingly", + "sites", + "process", "achieved", - "systems", "reliably", + "use", + "pcomp", "analytical", - "stability", - "functional", - "ideally", + "directing", + "highly", + "available", + "benefit", "components", "chemical", - "defined", - "literature", - "would", - "dimer", - "help", - "engineering", - "respects", - "design", - "introduce", - "present", - "states", "required", - "applications", - "sequence", - "could", - "key", - "hitherto", - "registry", - "known", - "structural", - "tetrameric", - "sites", - "designs", - "one", - "endeavors", + "peptide", + "set", + "maintaining", "toolkit", - "novo", + "design", + "specification", + "spectroscopy", + "help", + "used", + "feature", "hold", - "desired", + "functional", + "biology", + "empirical", + "potential", + "specify", + "oligomeric", + "assembly", + "considered", + "literature", + "relationships", + "solution", + "oligomer", + "parallel", + "sequence", + "states", + "system", "peptides", + "kept", + "present", + "toolkits", + "desired", + "mutation", "ultracentrifugation", - "spectroscopy", - "benefit", - "confirmed", - "system", + "could", + "designed", + "trimeric", + "analysis", + "particular", + "registry", + "sequences", + "one", + "targeted", + "structures", + "de", + "exchanged", + "respects", + "based", + "structure", + "synthetic", + "introduce", + "determined", + "give", + "crystallography", + "interactions", "state", - "set", - "envisage", - "considered", - "protein", + "function", + "known", + "would", "outside", - "oligomeric" + "database", + "designs", + "envisage", + "dimeric" ], "release_date":"2012-08-29", "publication":"\"A basis set of de novo coiled-coil Peptide oligomers for rational protein design and synthetic biology\", ACS Synth Biol, 1, 240-250", @@ -72224,118 +72306,118 @@ "de novo protein" ], "keywords":[ - "analysis", + "engineering", + "defined", + "redesign", + "adopt", + "structural", + "key", "background", - "available", - "specificity", - "use", - "crystallography", - "peptide", - "designed", - "directing", - "dimeric", - "mutation", - "parallel", - "experimentally", + "endeavors", + "ideally", + "integrity", + "protein", + "controlling", + "positions", + "tetrameric", + "confirmed", + "novo", + "systems", + "applications", + "establish", "crystal", - "determined", - "potential", "referred", - "based", - "sequences", - "basis", - "synthetic", - "interactions", - "adopt", - "kept", - "structure", - "establish", - "redesign", - "database", - "oligomer", "later", - "however", - "maintaining", - "intriguingly", - "process", - "de", - "integrity", "characterized", - "toolkits", - "feature", - "specify", - "used", - "highly", - "targeted", - "exchanged", - "relationships", - "controlling", - "pcomp", - "trimeric", - "foreground", - "structures", - "empirical", - "positions", + "however", + "specificity", "predictable", + "dimer", + "experimentally", + "hitherto", "widely", - "solution", - "specification", - "function", - "give", - "particular", - "assembly", - "biology", + "basis", + "stability", + "foreground", + "intriguingly", + "sites", + "process", "achieved", - "systems", "reliably", + "use", + "pcomp", "analytical", - "stability", - "functional", - "ideally", + "directing", + "highly", + "available", + "benefit", "components", "chemical", - "defined", - "literature", - "would", - "dimer", - "help", - "engineering", - "respects", - "design", - "introduce", - "present", - "states", "required", - "applications", - "sequence", - "could", - "key", - "hitherto", - "registry", - "known", - "structural", - "tetrameric", - "sites", - "designs", - "one", - "endeavors", + "peptide", + "set", + "maintaining", "toolkit", - "novo", + "design", + "specification", + "spectroscopy", + "help", + "used", + "feature", "hold", - "desired", + "functional", + "biology", + "empirical", + "potential", + "specify", + "oligomeric", + "assembly", + "considered", + "literature", + "relationships", + "solution", + "oligomer", + "parallel", + "sequence", + "states", + "system", "peptides", + "kept", + "present", + "toolkits", + "desired", + "mutation", "ultracentrifugation", - "spectroscopy", - "benefit", - "confirmed", - "system", + "could", + "designed", + "trimeric", + "analysis", + "particular", + "registry", + "sequences", + "one", + "targeted", + "structures", + "de", + "exchanged", + "respects", + "based", + "structure", + "synthetic", + "introduce", + "determined", + "give", + "crystallography", + "interactions", "state", - "set", - "envisage", - "considered", - "protein", + "function", + "known", + "would", "outside", - "oligomeric" + "database", + "designs", + "envisage", + "dimeric" ], "release_date":"2012-08-29", "publication":"\"A basis set of de novo coiled-coil Peptide oligomers for rational protein design and synthetic biology\", ACS Synth Biol, 1, 240-250", @@ -72372,14 +72454,6 @@ ], "struct_thr_sim_designed":[ - { - "sim":0.9805999994, - "partner":"4dzn" - }, - { - "sim":0.9786999822, - "partner":"4h7r" - }, { "sim":0.9761999846, "partner":"4dzk" @@ -72408,6 +72482,14 @@ "sim":0.9772999883, "partner":"6q5n" }, + { + "sim":0.9805999994, + "partner":"4dzn" + }, + { + "sim":0.9786999822, + "partner":"4h7r" + }, { "sim":0.9800000191, "partner":"3r4h" @@ -72610,118 +72692,118 @@ "de novo protein" ], "keywords":[ - "analysis", + "engineering", + "defined", + "redesign", + "adopt", + "structural", + "key", "background", - "available", - "specificity", - "use", - "crystallography", - "peptide", - "designed", - "directing", - "dimeric", - "mutation", - "parallel", - "experimentally", + "endeavors", + "ideally", + "integrity", + "protein", + "controlling", + "positions", + "tetrameric", + "confirmed", + "novo", + "systems", + "applications", + "establish", "crystal", - "determined", - "potential", "referred", - "based", - "sequences", - "basis", - "synthetic", - "interactions", - "adopt", - "kept", - "structure", - "establish", - "redesign", - "database", - "oligomer", "later", - "however", - "maintaining", - "intriguingly", - "process", - "de", - "integrity", "characterized", - "toolkits", - "feature", - "specify", - "used", - "highly", - "targeted", - "exchanged", - "relationships", - "controlling", - "pcomp", - "trimeric", - "foreground", - "structures", - "empirical", - "positions", + "however", + "specificity", "predictable", + "dimer", + "experimentally", + "hitherto", "widely", - "solution", - "specification", - "function", - "give", - "particular", - "assembly", - "biology", + "basis", + "stability", + "foreground", + "intriguingly", + "sites", + "process", "achieved", - "systems", "reliably", + "use", + "pcomp", "analytical", - "stability", - "functional", - "ideally", + "directing", + "highly", + "available", + "benefit", "components", "chemical", - "defined", - "literature", - "would", - "dimer", - "help", - "engineering", - "respects", - "design", - "introduce", - "present", - "states", "required", - "applications", - "sequence", - "could", - "key", - "hitherto", - "registry", - "known", - "structural", - "tetrameric", - "sites", - "designs", - "one", - "endeavors", + "peptide", + "set", + "maintaining", "toolkit", - "novo", + "design", + "specification", + "spectroscopy", + "help", + "used", + "feature", "hold", - "desired", + "functional", + "biology", + "empirical", + "potential", + "specify", + "oligomeric", + "assembly", + "considered", + "literature", + "relationships", + "solution", + "oligomer", + "parallel", + "sequence", + "states", + "system", "peptides", + "kept", + "present", + "toolkits", + "desired", + "mutation", "ultracentrifugation", - "spectroscopy", - "benefit", - "confirmed", - "system", + "could", + "designed", + "trimeric", + "analysis", + "particular", + "registry", + "sequences", + "one", + "targeted", + "structures", + "de", + "exchanged", + "respects", + "based", + "structure", + "synthetic", + "introduce", + "determined", + "give", + "crystallography", + "interactions", "state", - "set", - "envisage", - "considered", - "protein", + "function", + "known", + "would", "outside", - "oligomeric" + "database", + "designs", + "envisage", + "dimeric" ], "release_date":"2012-08-29", "publication":"\"A basis set of de novo coiled-coil Peptide oligomers for rational protein design and synthetic biology\", ACS Synth Biol, 1, 240-250", @@ -72900,118 +72982,118 @@ "de novo protein" ], "keywords":[ - "analysis", + "engineering", + "defined", + "redesign", + "adopt", + "structural", + "key", "background", - "available", - "specificity", - "use", - "crystallography", - "peptide", - "designed", - "directing", - "dimeric", - "mutation", - "parallel", - "experimentally", + "endeavors", + "ideally", + "integrity", + "protein", + "controlling", + "positions", + "tetrameric", + "confirmed", + "novo", + "systems", + "applications", + "establish", "crystal", - "determined", - "potential", "referred", - "based", - "sequences", - "basis", - "synthetic", - "interactions", - "adopt", - "kept", - "structure", - "establish", - "redesign", - "database", - "oligomer", "later", - "however", - "maintaining", - "intriguingly", - "process", - "de", - "integrity", "characterized", - "toolkits", - "feature", - "specify", - "used", - "highly", - "targeted", - "exchanged", - "relationships", - "controlling", - "pcomp", - "trimeric", - "foreground", - "structures", - "empirical", - "positions", + "however", + "specificity", "predictable", + "dimer", + "experimentally", + "hitherto", "widely", - "solution", - "specification", - "function", - "give", - "particular", - "assembly", - "biology", + "basis", + "stability", + "foreground", + "intriguingly", + "sites", + "process", "achieved", - "systems", "reliably", + "use", + "pcomp", "analytical", - "stability", - "functional", - "ideally", + "directing", + "highly", + "available", + "benefit", "components", "chemical", - "defined", - "literature", - "would", - "dimer", - "help", - "engineering", - "respects", - "design", - "introduce", - "present", - "states", "required", - "applications", - "sequence", - "could", - "key", - "hitherto", - "registry", - "known", - "structural", - "tetrameric", - "sites", - "designs", - "one", - "endeavors", + "peptide", + "set", + "maintaining", "toolkit", - "novo", + "design", + "specification", + "spectroscopy", + "help", + "used", + "feature", "hold", - "desired", + "functional", + "biology", + "empirical", + "potential", + "specify", + "oligomeric", + "assembly", + "considered", + "literature", + "relationships", + "solution", + "oligomer", + "parallel", + "sequence", + "states", + "system", "peptides", + "kept", + "present", + "toolkits", + "desired", + "mutation", "ultracentrifugation", - "spectroscopy", - "benefit", - "confirmed", - "system", + "could", + "designed", + "trimeric", + "analysis", + "particular", + "registry", + "sequences", + "one", + "targeted", + "structures", + "de", + "exchanged", + "respects", + "based", + "structure", + "synthetic", + "introduce", + "determined", + "give", + "crystallography", + "interactions", "state", - "set", - "envisage", - "considered", - "protein", + "function", + "known", + "would", "outside", - "oligomeric" + "database", + "designs", + "envisage", + "dimeric" ], "release_date":"2012-08-29", "publication":"\"A basis set of de novo coiled-coil Peptide oligomers for rational protein design and synthetic biology\", ACS Synth Biol, 1, 240-250", @@ -73048,6 +73130,14 @@ ], "struct_thr_sim_designed":[ + { + "sim":0.9768999815, + "partner":"4dzl" + }, + { + "sim":0.9703999758, + "partner":"4h7r" + }, { "sim":0.9585999846, "partner":"4dzm" @@ -73056,17 +73146,9 @@ "sim":0.9603999853, "partner":"4h8f" }, - { - "sim":0.9703999758, - "partner":"4h7r" - }, { "sim":0.9603999853, "partner":"3r48" - }, - { - "sim":0.9768999815, - "partner":"4dzl" } ], "struct_thr_sim_natural":[ @@ -73153,90 +73235,90 @@ ], "subtitle":"Complex of 3-alpha bound to gp41-5", "tags":[ - "viral fusion", - "de novo protein" + "de novo protein", + "viral fusion" ], "keywords":[ - "cyclically", - "domain", - "require", - "\u03b2", - "acidic", - "use", - "suggest", - "biochemical", - "hiv", - "preorganization", - "basic", - "analogue", - "near", - "provide", - "entropically", - "crystal", - "ionic", - "based", - "show", - "costly", - "manifest", - "however", - "cyclic", - "array", - "sparser", - "produce", - "indicated", - "involved", - "resulting", - "used", - "assays", - "little", - "disorder", "constrained", - "effective", - "structures", - "arrays", - "introduction", - "helicity", - "previously", + "show", + "infectivity", + "side", "addressed", - "cleavage", "via", - "coulombic", - "report", - "dense", - "method", - "ordering", - "bundle", - "design", "gp41", - "proteolysis", - "comparably", - "susceptibility", - "promote", - "ion", + "assays", + "new", + "residue", + "preorganization", + "protein", + "hiv", + "biochemical", + "indicated", + "little", + "sparser", "stabilization", - "attractions", - "chains", + "pair", + "cyclically", + "cleavage", + "site", "susceptible", - "observations", + "crystal", + "stable", "helices", + "chains", + "involved", + "introduction", + "engineered", + "analogue", + "entropically", "conformational", + "however", + "ordering", + "disorder", "mimicry", - "stable", - "engineered", - "residues", "identified", - "complementary", - "protein", - "residue", - "chr", + "residues", + "proteolysis", "helix", - "infectivity", - "analogous", - "side", - "site", - "pair", + "cyclic", + "use", + "suggest", "contain", - "new" + "complementary", + "bundle", + "susceptibility", + "effective", + "design", + "coulombic", + "used", + "costly", + "produce", + "domain", + "analogous", + "ionic", + "near", + "chr", + "method", + "helicity", + "basic", + "require", + "array", + "structures", + "attractions", + "previously", + "based", + "dense", + "\u03b2", + "acidic", + "comparably", + "report", + "provide", + "resulting", + "ion", + "promote", + "arrays", + "manifest", + "observations" ], "release_date":"2012-05-02", "publication":"\"Enhancement of alpha-helix mimicry by an alpha \/ beta-peptide foldamer via incorporation of a dense ionic side-chain array\", J.Am.Chem.Soc., 134, 7317-7320", @@ -73389,6 +73471,22 @@ "sim":104.0, "partner":"2kp8" }, + { + "sim":99.0, + "partner":"9axd" + }, + { + "sim":99.0, + "partner":"9ays" + }, + { + "sim":99.0, + "partner":"9ay6" + }, + { + "sim":93.0, + "partner":"9ayv" + }, { "sim":86.0, "partner":"1jpx" @@ -73397,6 +73495,18 @@ "sim":86.0, "partner":"1jq0" }, + { + "sim":85.0, + "partner":"9atz" + }, + { + "sim":85.0, + "partner":"9axi" + }, + { + "sim":85.0, + "partner":"9axk" + }, { "sim":72.0, "partner":"1aik" @@ -73461,10 +73571,6 @@ "sim":59.0, "partner":"2zfc" }, - { - "sim":54.0, - "partner":"1qbz" - }, { "sim":54.0, "partner":"2ezo" @@ -73489,6 +73595,10 @@ "sim":54.0, "partner":"1qce" }, + { + "sim":54.0, + "partner":"1qbz" + }, { "sim":51.0, "partner":"3h00" @@ -73590,91 +73700,91 @@ ], "subtitle":"Complex of 4-alpha\/beta bound to gp41-5", "tags":[ + "de novo protein", "viral fusion", - "beta amino acid", - "de novo protein" + "beta amino acid" ], "keywords":[ - "cyclically", - "domain", - "require", - "\u03b2", - "acidic", - "use", - "suggest", - "biochemical", - "hiv", - "preorganization", - "basic", - "analogue", - "near", - "provide", - "entropically", - "crystal", - "ionic", - "based", - "show", - "costly", - "manifest", - "however", - "cyclic", - "array", - "sparser", - "produce", - "indicated", - "involved", - "resulting", - "used", - "assays", - "little", - "disorder", "constrained", - "effective", - "structures", - "arrays", - "introduction", - "helicity", - "previously", + "show", + "infectivity", + "side", "addressed", - "cleavage", "via", - "coulombic", - "report", - "dense", - "method", - "ordering", - "bundle", - "design", "gp41", - "proteolysis", - "comparably", - "susceptibility", - "promote", - "ion", + "assays", + "new", + "residue", + "preorganization", + "protein", + "hiv", + "biochemical", + "indicated", + "little", + "sparser", "stabilization", - "attractions", - "chains", + "pair", + "cyclically", + "cleavage", + "site", "susceptible", - "observations", + "crystal", + "stable", "helices", + "chains", + "involved", + "introduction", + "engineered", + "analogue", + "entropically", "conformational", + "however", + "ordering", + "disorder", "mimicry", - "stable", - "engineered", - "residues", "identified", - "complementary", - "protein", - "residue", - "chr", + "residues", + "proteolysis", "helix", - "infectivity", - "analogous", - "side", - "site", - "pair", + "cyclic", + "use", + "suggest", "contain", - "new" + "complementary", + "bundle", + "susceptibility", + "effective", + "design", + "coulombic", + "used", + "costly", + "produce", + "domain", + "analogous", + "ionic", + "near", + "chr", + "method", + "helicity", + "basic", + "require", + "array", + "structures", + "attractions", + "previously", + "based", + "dense", + "\u03b2", + "acidic", + "comparably", + "report", + "provide", + "resulting", + "ion", + "promote", + "arrays", + "manifest", + "observations" ], "release_date":"2012-05-02", "publication":"\"Enhancement of alpha-helix mimicry by an alpha \/ beta-peptide foldamer via incorporation of a dense ionic side-chain array\", J.Am.Chem.Soc., 134, 7317-7320", @@ -73827,6 +73937,22 @@ "sim":104.0, "partner":"2kp8" }, + { + "sim":99.0, + "partner":"9axd" + }, + { + "sim":99.0, + "partner":"9ays" + }, + { + "sim":99.0, + "partner":"9ay6" + }, + { + "sim":93.0, + "partner":"9ayv" + }, { "sim":86.0, "partner":"1jpx" @@ -73835,6 +73961,18 @@ "sim":86.0, "partner":"1jq0" }, + { + "sim":85.0, + "partner":"9atz" + }, + { + "sim":85.0, + "partner":"9axi" + }, + { + "sim":85.0, + "partner":"9axk" + }, { "sim":72.0, "partner":"1aik" @@ -73899,10 +74037,6 @@ "sim":59.0, "partner":"2zfc" }, - { - "sim":54.0, - "partner":"1qbz" - }, { "sim":54.0, "partner":"2ezo" @@ -73927,6 +74061,10 @@ "sim":54.0, "partner":"1qce" }, + { + "sim":54.0, + "partner":"1qbz" + }, { "sim":51.0, "partner":"3h00" @@ -74033,12 +74171,12 @@ ], "subtitle":"Crystal structure of de novo designed cysteine esterase ech13, northeast structural genomics consortium target or51", "tags":[ + "nesg", "northeast structural genomics consortium", "hydrolase", + "psi-biology", "structural genomics", - "protein structure initiative", - "nesg", - "psi-biology" + "protein structure initiative" ], "keywords":[ "description", @@ -74078,23 +74216,23 @@ "seq_thr_sim_natural":[ { "sim":447.0, - "partner":"3u19" + "partner":"3u13" }, { "sim":447.0, - "partner":"3u13" + "partner":"3u19" }, { "sim":399.0, - "partner":"1mh9" + "partner":"1q91" }, { "sim":399.0, - "partner":"1q91" + "partner":"1q92" }, { "sim":399.0, - "partner":"1q92" + "partner":"1mh9" }, { "sim":397.0, @@ -74138,11 +74276,11 @@ }, { "sim":260.0, - "partner":"2jar" + "partner":"2jao" }, { "sim":260.0, - "partner":"2jao" + "partner":"2jar" }, { "sim":59.0, @@ -74167,7 +74305,7 @@ ], "seq_max_sim_natural":{ "sim":447.0, - "partner":"3u19" + "partner":"3u13" }, "struct_max_sim_designed":{ "sim":0.3551000059, @@ -74258,102 +74396,102 @@ ], "subtitle":"Crystal structure of e6d\/l155r variant of de novo designed serine hydrolase osh55, northeast structural genomics consortium (nesg) target or187", "tags":[ - "serine hydrolase", + "osh55 mutant e6d\/l159r", + "protein structure initiative", + "de novo protein", "northeast structural genomics consortium (nesg) target or187", "hydrolase", "structural genomics", - "protein structure initiative", - "de novo protein", + "serine hydrolase", "psi-biology", - "de novo protein, hydrolase", - "osh55 mutant e6d\/l159r" + "de novo protein, hydrolase" ], "keywords":[ - "fluorophosphate", - "many", - "multiple", - "must", - "suggest", - "idealized", - "challenge", - "including", - "provide", - "triads", - "crystal", + "triad", "limited", + "yeast", + "optimized", "show", - "basis", + "single", + "multiple", + "idealized", + "simultaneously", "assess", - "display", + "nucleophilicity", + "residue", + "new", + "probes", + "hydrolases", + "product", + "binding", + "focus", + "following", + "stabilization", + "initiates", + "extensive", + "site", "networks", - "catalysis", - "rates", - "proteins", - "models", - "enzymes", + "demonstrate", + "systems", + "catalytic", + "crystal", + "using", "reactivity", - "focus", - "absolute", - "substrate", - "bonding", - "comparable", - "structures", + "agreement", + "react", + "biological", + "residues", "capture", - "natural", - "organophosphate", - "native", "transition", - "extensive", - "simultaneously", - "systems", - "hydrogen", - "triad", - "properties", - "following", - "diisopropyl", - "directly", - "serine", "release", - "catalytic", - "class", + "organophosphate", "optimization", + "basis", + "bound", + "proteins", + "enzymes", + "hydrogen", + "activation", + "suggest", + "absolute", + "unprecedented", + "computational", + "rates", + "serine", + "including", + "bonding", + "property", + "mutagenesis", + "agents", + "design", + "critical", + "must", "active", + "natural", + "substrate", + "display", + "properties", + "experiments", "successful", - "agreement", - "activity", - "design", + "quartet", + "diisopropyl", "nucleophile", - "using", - "agents", - "initiates", - "biological", - "property", + "catalysis", "could", - "stabilization", - "demonstrate", - "designs", - "nucleophilicity", - "critical", - "optimized", - "single", - "unprecedented", - "product", - "experiments", - "residues", - "react", + "directly", + "fluorophosphate", + "models", + "many", + "structures", + "comparable", + "provide", "state", - "hydrolases", - "quartet", - "bound", - "residue", - "binding", - "computational", - "yeast", - "activation", - "site", - "probes", - "mutagenesis", - "new" + "class", + "activity", + "native", + "triads", + "challenge", + "designs" ], "release_date":"2012-06-13", "publication":"\"Design of activated serine-containing catalytic triads with atomic-level accuracy\", Nat.Chem.Biol., 10, 386-391", @@ -74546,99 +74684,99 @@ ], "subtitle":"Crystal structure of e6h variant of de novo designed serine hydrolase osh55, northeast structural genomics consortium (nesg) target or185", "tags":[ + "nesg", + "de novo protein", "northeast structural genomics consortium", + "psi-biology", "structural genomics", - "protein structure initiative", - "de novo protein", - "nesg", - "psi-biology" + "protein structure initiative" ], "keywords":[ - "fluorophosphate", - "many", - "multiple", - "must", - "suggest", - "idealized", - "challenge", - "including", - "provide", - "triads", - "crystal", + "triad", "limited", + "yeast", + "optimized", "show", - "basis", + "single", + "multiple", + "idealized", + "simultaneously", "assess", - "display", + "nucleophilicity", + "residue", + "new", + "probes", + "hydrolases", + "product", + "binding", + "focus", + "following", + "stabilization", + "initiates", + "extensive", + "site", "networks", - "catalysis", - "rates", - "proteins", - "models", - "enzymes", + "demonstrate", + "systems", + "catalytic", + "crystal", + "using", "reactivity", - "focus", - "absolute", - "substrate", - "bonding", - "comparable", - "structures", + "agreement", + "react", + "biological", + "residues", "capture", - "natural", - "organophosphate", - "native", "transition", - "extensive", - "simultaneously", - "systems", - "hydrogen", - "triad", - "properties", - "following", - "diisopropyl", - "directly", - "serine", "release", - "catalytic", - "class", + "organophosphate", "optimization", + "basis", + "bound", + "proteins", + "enzymes", + "hydrogen", + "activation", + "suggest", + "absolute", + "unprecedented", + "computational", + "rates", + "serine", + "including", + "bonding", + "property", + "mutagenesis", + "agents", + "design", + "critical", + "must", "active", + "natural", + "substrate", + "display", + "properties", + "experiments", "successful", - "agreement", - "activity", - "design", + "quartet", + "diisopropyl", "nucleophile", - "using", - "agents", - "initiates", - "biological", - "property", + "catalysis", "could", - "stabilization", - "demonstrate", - "designs", - "nucleophilicity", - "critical", - "optimized", - "single", - "unprecedented", - "product", - "experiments", - "residues", - "react", + "directly", + "fluorophosphate", + "models", + "many", + "structures", + "comparable", + "provide", "state", - "hydrolases", - "quartet", - "bound", - "residue", - "binding", - "computational", - "yeast", - "activation", - "site", - "probes", - "mutagenesis", - "new" + "class", + "activity", + "native", + "triads", + "challenge", + "designs" ], "release_date":"2012-06-13", "publication":"\"Design of activated serine-containing catalytic triads with atomic-level accuracy\", Nat.Chem.Biol., 10, 386-391", @@ -74831,100 +74969,100 @@ ], "subtitle":"Crystal structure of de novo designed serine hydrolase, northeast structural genomics consortium (nesg) target or165", "tags":[ - "northeast structural genomics consortium", - "structural genomics", - "protein structure initiative", - "de novo protein", + "de novo design", "nesg", + "de novo protein", + "northeast structural genomics consortium", "psi-biology", - "de novo design" + "structural genomics", + "protein structure initiative" ], "keywords":[ - "fluorophosphate", - "many", - "multiple", - "must", - "suggest", - "idealized", - "challenge", - "including", - "provide", - "triads", - "crystal", + "triad", "limited", + "yeast", + "optimized", "show", - "basis", + "single", + "multiple", + "idealized", + "simultaneously", "assess", - "display", + "nucleophilicity", + "residue", + "new", + "probes", + "hydrolases", + "product", + "binding", + "focus", + "following", + "stabilization", + "initiates", + "extensive", + "site", "networks", - "catalysis", - "rates", - "proteins", - "models", - "enzymes", + "demonstrate", + "systems", + "catalytic", + "crystal", + "using", "reactivity", - "focus", - "absolute", - "substrate", - "bonding", - "comparable", - "structures", + "agreement", + "react", + "biological", + "residues", "capture", - "natural", - "organophosphate", - "native", "transition", - "extensive", - "simultaneously", - "systems", - "hydrogen", - "triad", - "properties", - "following", - "diisopropyl", - "directly", - "serine", "release", - "catalytic", - "class", + "organophosphate", "optimization", + "basis", + "bound", + "proteins", + "enzymes", + "hydrogen", + "activation", + "suggest", + "absolute", + "unprecedented", + "computational", + "rates", + "serine", + "including", + "bonding", + "property", + "mutagenesis", + "agents", + "design", + "critical", + "must", "active", + "natural", + "substrate", + "display", + "properties", + "experiments", "successful", - "agreement", - "activity", - "design", + "quartet", + "diisopropyl", "nucleophile", - "using", - "agents", - "initiates", - "biological", - "property", + "catalysis", "could", - "stabilization", - "demonstrate", - "designs", - "nucleophilicity", - "critical", - "optimized", - "single", - "unprecedented", - "product", - "experiments", - "residues", - "react", + "directly", + "fluorophosphate", + "models", + "many", + "structures", + "comparable", + "provide", "state", - "hydrolases", - "quartet", - "bound", - "residue", - "binding", - "computational", - "yeast", - "activation", - "site", - "probes", - "mutagenesis", - "new" + "class", + "activity", + "native", + "triads", + "challenge", + "designs" ], "release_date":"2012-05-30", "publication":"\"Design of activated serine-containing catalytic triads with atomic-level accuracy\", Nat.Chem.Biol., 10, 386-391", @@ -74964,11 +75102,11 @@ }, { "sim":539.0, - "partner":"1bq2" + "partner":"3bgx" }, { "sim":539.0, - "partner":"3bgx" + "partner":"1bq2" }, { "sim":539.0, @@ -74984,23 +75122,23 @@ }, { "sim":537.0, - "partner":"1f4b" + "partner":"1kce" }, { "sim":537.0, - "partner":"1aob" + "partner":"3b9h" }, { "sim":537.0, - "partner":"1f4c" + "partner":"1f4b" }, { "sim":537.0, - "partner":"1kce" + "partner":"1aob" }, { "sim":537.0, - "partner":"3b9h" + "partner":"1f4c" }, { "sim":537.0, @@ -75008,31 +75146,31 @@ }, { "sim":537.0, - "partner":"1f4e" + "partner":"1zpr" }, { "sim":537.0, - "partner":"1zpr" + "partner":"1f4e" }, { "sim":537.0, - "partner":"1f4f" + "partner":"1kzi" }, { "sim":537.0, - "partner":"1jtq" + "partner":"1f4f" }, { "sim":537.0, - "partner":"1f4g" + "partner":"1jtq" }, { "sim":537.0, - "partner":"1kzi" + "partner":"2kce" }, { "sim":537.0, - "partner":"2kce" + "partner":"1f4g" }, { "sim":537.0, @@ -75068,7 +75206,7 @@ }, { "sim":537.0, - "partner":"1tjs" + "partner":"1tsd" }, { "sim":537.0, @@ -75076,23 +75214,19 @@ }, { "sim":537.0, - "partner":"1bdu" - }, - { - "sim":537.0, - "partner":"1tsd" + "partner":"1trg" }, { "sim":537.0, - "partner":"1axw" + "partner":"1bdu" }, { "sim":537.0, - "partner":"1trg" + "partner":"1tdu" }, { "sim":537.0, - "partner":"1tdu" + "partner":"1axw" }, { "sim":537.0, @@ -75110,6 +75244,10 @@ "sim":537.0, "partner":"1tlc" }, + { + "sim":537.0, + "partner":"1tjs" + }, { "sim":536.0, "partner":"1evf" @@ -75126,21 +75264,13 @@ "sim":536.0, "partner":"2ftn" }, - { - "sim":536.0, - "partner":"1ev5" - }, { "sim":536.0, "partner":"2fto" }, { - "sim":535.0, - "partner":"2g8x" - }, - { - "sim":535.0, - "partner":"2vet" + "sim":536.0, + "partner":"1ev5" }, { "sim":535.0, @@ -75160,11 +75290,11 @@ }, { "sim":535.0, - "partner":"1fwm" + "partner":"3b5b" }, { "sim":535.0, - "partner":"3b5b" + "partner":"1fwm" }, { "sim":535.0, @@ -75182,6 +75312,14 @@ "sim":535.0, "partner":"1aiq" }, + { + "sim":535.0, + "partner":"2g8x" + }, + { + "sim":535.0, + "partner":"2vet" + }, { "sim":534.0, "partner":"3bfi" @@ -75242,10 +75380,6 @@ "sim":284.0, "partner":"1tvw" }, - { - "sim":283.0, - "partner":"3ijz" - }, { "sim":283.0, "partner":"3ik0" @@ -75270,10 +75404,6 @@ "sim":283.0, "partner":"1lca" }, - { - "sim":283.0, - "partner":"1jmh" - }, { "sim":283.0, "partner":"1lcb" @@ -75290,6 +75420,10 @@ "sim":283.0, "partner":"1thy" }, + { + "sim":283.0, + "partner":"1jmh" + }, { "sim":283.0, "partner":"1tsl" @@ -75330,6 +75464,10 @@ "sim":283.0, "partner":"3c06" }, + { + "sim":283.0, + "partner":"3ijz" + }, { "sim":282.0, "partner":"2tdd" @@ -75380,23 +75518,23 @@ }, { "sim":280.0, - "partner":"1tsv" + "partner":"1bo7" }, { "sim":280.0, - "partner":"1tsw" + "partner":"1bo8" }, { "sim":280.0, - "partner":"1bo7" + "partner":"2g8a" }, { "sim":280.0, - "partner":"1bo8" + "partner":"1tsv" }, { "sim":280.0, - "partner":"2g8a" + "partner":"1tsw" }, { "sim":279.0, @@ -75414,10 +75552,6 @@ "sim":277.0, "partner":"1bp6" }, - { - "sim":265.0, - "partner":"4eb4" - }, { "sim":265.0, "partner":"3ihi" @@ -75428,11 +75562,11 @@ }, { "sim":265.0, - "partner":"2rda" + "partner":"4eb4" }, { "sim":265.0, - "partner":"3eaw" + "partner":"2rda" }, { "sim":265.0, @@ -75490,6 +75624,10 @@ "sim":265.0, "partner":"3edw" }, + { + "sim":265.0, + "partner":"3eaw" + }, { "sim":265.0, "partner":"3n5e" @@ -75524,11 +75662,11 @@ }, { "sim":263.0, - "partner":"3egy" + "partner":"3ehi" }, { "sim":263.0, - "partner":"3ehi" + "partner":"3egy" }, { "sim":262.0, @@ -75788,81 +75926,81 @@ ], "subtitle":"Crystal structure of the uranyl binding protein complexed with uranyl", "tags":[ - "unknown function", - "uranyl binding" + "uranyl binding", + "unknown function" ], "keywords":[ - "sites", - "makes", - "per", - "demonstrated", - "nm", - "proteins", + "affinity", + "form", + "search", "employed", - "uranyl", - "similar", - "also", - "chemical", - "concentration", - "report", - "process", - "stable", - "rational", + "thermally", + "limited", + "initial", + "design", + "predominant", + "engineered", + "however", "metal", - "ions", - "screening", - "search", - "repeatedly", + "offers", + "development", + "concentrations", + "kd", + "rational", + "potential", + "nm", + "selective", + "synthetic", + "sequester", + "report", + "charge", + "also", "strategy", + "uo2", "parts", "uranium", - "charge", - "may", - "engineered", - "10", - "9", - "engineer", "successful", - "difficult", + "makes", + "protein", "selectivity", - "initial", + "9", + "sites", + "proteins", + "binding", + "process", "motif", + "ions", + "size", + "concentration", + "may", + "high", + "applied", + "uranyl", + "demonstrated", + "difficult", + "remediation", "fm", - "resource", - "limited", - "potential", - "design", - "selective", - "predominant", - "femtomolar", - "protein", - "synthetic", - "using", - "offers", + "vast", + "repeatedly", "present", - "kd", - "sequester", + "ocean", + "enrichment", + "stable", "sea", - "vast", - "remediation", - "development", + "chemical", "applications", - "high", - "water", - "thermally", - "size", - "uo2", + "screening", + "10", + "femtomolar", + "engineer", + "similar", "computational", - "applied", - "form", - "ocean", - "however", - "affinity", + "using", "biotechnology", + "resource", + "per", "aerobic", - "binding", - "concentrations", - "enrichment" + "water" ], "release_date":"2013-12-11", "publication":"\"A protein engineered to bind uranyl selectively and with femtomolar affinity\", Nat Chem, 6, 236-241", @@ -75976,120 +76114,120 @@ ], "subtitle":"Metal-binding properties of a self-assembled coiled coil: formation of a polynuclear cd-thiolated cluster", "tags":[ - "metal binding protein", - "metallopeptide complexes", "helical bundles", - "polynuclear metal-binding", "cd(ii)", - "self-assembly" + "self-assembly", + "metallopeptide complexes", + "polynuclear metal-binding", + "metal binding protein" ], "keywords":[ + "repeats", + "multiangle", + "7", + "ionization", + "hydrophobic", + "resolution", + "core", + "three", + "thiolate", + "within", + "acid", + "polypeptide", + "ligands", "results", - "studies", - "studied", - "describes", - "thus", - "use", + "residue", + "exhibits", "developing", - "scattering", - "metal", - "ions", - "cluster", - "acid", - "peptide", - "designed", "cd", - "stepwise", - "crystal", - "potential", - "synthetic", - "chromatography", - "electrospray", - "structure", - "multiangle", - "molecule", - "fashion", - "seven", - "coiled", - "composed", - "7", - "called", - "dominant", - "holoprotein", - "detection", - "paper", - "clusters", - "motif", - "3", + "six", + "mass", + "ph", "positions", - "center", - "coordinated", - "three", + "motif", "showed", - "revealed", + "glutamic", + "stepwise", + "demonstrate", + "apo", "circular", - "size", - "coil", - "ligands", - "form", - "cooperatively", - "properties", + "composed", + "crystal", + "113", + "water", + "metal", + "formed", + "exclusion", + "distorted", + "coordinated", + "thus", + "residues", + "studied", "esi", - "exhibits", - "geometry", - "oligomerization", - "cadmium", - "resolution", + "tetrahedral", + "sulfur", + "characterization", + "size", + "ions", + "scattering", + "use", + "center", + "found", + "contain", "four", - "redox", + "detection", + "peptide", + "molecule", "configuration", - "apo", - "six", - "glutamic", - "design", - "polypeptide", - "characterization", - "core", + "redox", "agents", - "hydrophobic", - "polynuclear", - "nmr", - "thiolate", + "design", + "spectroscopy", + "metalloenzymes", + "resolved", + "potential", + "clusters", + "dominant", + "consisting", + "properties", + "called", + "cysteine", + "light", + "oligomerization", + "chromatography", + "describes", "sequence", - "repeats", + "substituted", "techniques", - "ph", - "sulfur", - "exclusion", - "multinuclear", + "polynuclear", "incorporate", - "ion", - "distorted", - "demonstrate", - "consisting", - "substituted", - "cysteine", + "ms", + "form", + "designed", + "revealed", + "cooperatively", + "multinuclear", "one", - "exogenous", - "ionization", - "spectroscopy", - "residues", - "found", + "cadmium", + "geometry", + "3", + "structure", + "synthetic", + "nmr", "state", - "light", - "tetrahedral", - "residue", - "113", - "spectrometry", - "water", - "ms", - "within", - "mass", + "ion", + "exogenous", + "cluster", + "fashion", + "coiled", + "coil", "dichroism", - "metalloenzymes", - "formed", - "contain", - "resolved" + "seven", + "studies", + "electrospray", + "spectrometry", + "paper", + "holoprotein" ], "release_date":"2012-12-05", "publication":"\"Metal-binding properties and structural characterization of a self-assembled coiled coil: Formation of a polynuclear Cd-thiolate cluster\", J.Inorg.Biochem., 119C, 1-9", @@ -76188,87 +76326,87 @@ ], "subtitle":"Crystal structure of the de novo designed fluorinated peptide alpha4f3d", "tags":[ + "de novo protein", "coiled-coil", - "de novo designed", + "alpha helix", "fluorinated protein", - "de novo protein", - "alpha helix" + "de novo designed" ], "keywords":[ - "stability", - "thermal", - "toward", - "parent", - "data", - "unfolding", - "replace", - "results", - "causes", - "incorporation", - "amino", - "proteins", - "stabilizing", - "chemical", + "leucine", + "designed", + "surface", + "effective", "tbala", - "de", - "novo", - "changes", - "although", - "energies", - "contrast", - "increasing", + "especially", + "whose", + "hydrophobic", + "structural", "variants", + "cavity", + "analogs", + "fluorinated", + "well", + "structures", + "de", + "natural", + "stabilizing", + "core", + "respect", "area", + "three", + "residues", + "structure", + "causes", "rearrangement", - "acids", - "designed", "consequences", - "shape", - "well", - "analogs", + "results", + "determined", + "although", "resulting", - "residues", - "highly", - "especially", + "folding", + "mimic", "closely", + "shape", + "thermal", + "nonfluorinated", + "protein", + "buried", + "denaturation", + "idea", + "amino", + "stability", + "known", + "destabilizing", + "proteins", + "packing", "little", - "contains", - "leucine", + "changes", + "unfolding", "hfleu", + "formation", + "contrast", + "center", + "novo", + "contains", + "energies", "support", - "determined", - "mimic", - "bundle", - "destabilizing", - "fluorinated", - "hexafluoroleucine", - "cavity", - "core", - "denaturation", - "whose", - "effective", - "structures", - "protein", + "highly", + "acids", "cores", - "buried", - "respect", - "center", - "hydrophobic", - "natural", - "surface", - "structure", - "three", + "contain", + "parent", + "toward", + "data", + "chemical", "fluorination", + "incorporation", + "increasing", + "bundle", + "hexafluoroleucine", + "replace", "either", - "increase", - "idea", - "nonfluorinated", - "formation", - "known", - "folding", - "packing", - "structural", - "contain" + "increase" ], "release_date":"2012-10-31", "publication":"\"Comparison of the structures and stabilities of coiled-coil proteins containing hexafluoroleucine and t-butylalanine provides insight into the stabilizing effects of highly fluorinated amino acid side-chains\", Protein Sci., 21, 1705-1715", @@ -76370,87 +76508,87 @@ ], "subtitle":"Crystal structure of the de novo designed peptide alpha4tba6", "tags":[ + "de novo protein", "coiled-coil", + "alpha helix", "de novo designed", - "nonnatural amino acid", - "de novo protein", - "alpha helix" + "nonnatural amino acid" ], "keywords":[ - "stability", - "thermal", - "toward", - "parent", - "data", - "unfolding", - "replace", - "results", - "causes", - "incorporation", - "amino", - "proteins", - "stabilizing", - "chemical", + "leucine", + "designed", + "surface", + "effective", "tbala", - "de", - "novo", - "changes", - "although", - "energies", - "contrast", - "increasing", + "especially", + "whose", + "hydrophobic", + "structural", "variants", + "cavity", + "analogs", + "fluorinated", + "well", + "structures", + "de", + "natural", + "stabilizing", + "core", + "respect", "area", + "three", + "residues", + "structure", + "causes", "rearrangement", - "acids", - "designed", "consequences", - "shape", - "well", - "analogs", + "results", + "determined", + "although", "resulting", - "residues", - "highly", - "especially", + "folding", + "mimic", "closely", + "shape", + "thermal", + "nonfluorinated", + "protein", + "buried", + "denaturation", + "idea", + "amino", + "stability", + "known", + "destabilizing", + "proteins", + "packing", "little", - "contains", - "leucine", + "changes", + "unfolding", "hfleu", + "formation", + "contrast", + "center", + "novo", + "contains", + "energies", "support", - "determined", - "mimic", - "bundle", - "destabilizing", - "fluorinated", - "hexafluoroleucine", - "cavity", - "core", - "denaturation", - "whose", - "effective", - "structures", - "protein", + "highly", + "acids", "cores", - "buried", - "respect", - "center", - "hydrophobic", - "natural", - "surface", - "structure", - "three", + "contain", + "parent", + "toward", + "data", + "chemical", "fluorination", + "incorporation", + "increasing", + "bundle", + "hexafluoroleucine", + "replace", "either", - "increase", - "idea", - "nonfluorinated", - "formation", - "known", - "folding", - "packing", - "structural", - "contain" + "increase" ], "release_date":"2012-10-31", "publication":"\"Comparison of the structures and stabilities of coiled-coil proteins containing hexafluoroleucine and t-butylalanine provides insight into the stabilizing effects of highly fluorinated amino acid side-chains\", Protein Sci., 21, 1705-1715", @@ -76549,87 +76687,87 @@ ], "subtitle":"Crystal structure of the de novo designed fluorinated peptide alpha4f3(6-13)", "tags":[ + "de novo protein", "coiled-coil", - "de novo designed", + "alpha helix", "fluorinated protein", - "de novo protein", - "alpha helix" + "de novo designed" ], "keywords":[ - "stability", - "thermal", - "toward", - "parent", - "data", - "unfolding", - "replace", - "results", - "causes", - "incorporation", - "amino", - "proteins", - "stabilizing", - "chemical", + "leucine", + "designed", + "surface", + "effective", "tbala", - "de", - "novo", - "changes", - "although", - "energies", - "contrast", - "increasing", + "especially", + "whose", + "hydrophobic", + "structural", "variants", + "cavity", + "analogs", + "fluorinated", + "well", + "structures", + "de", + "natural", + "stabilizing", + "core", + "respect", "area", + "three", + "residues", + "structure", + "causes", "rearrangement", - "acids", - "designed", "consequences", - "shape", - "well", - "analogs", + "results", + "determined", + "although", "resulting", - "residues", - "highly", - "especially", + "folding", + "mimic", "closely", + "shape", + "thermal", + "nonfluorinated", + "protein", + "buried", + "denaturation", + "idea", + "amino", + "stability", + "known", + "destabilizing", + "proteins", + "packing", "little", - "contains", - "leucine", + "changes", + "unfolding", "hfleu", + "formation", + "contrast", + "center", + "novo", + "contains", + "energies", "support", - "determined", - "mimic", - "bundle", - "destabilizing", - "fluorinated", - "hexafluoroleucine", - "cavity", - "core", - "denaturation", - "whose", - "effective", - "structures", - "protein", + "highly", + "acids", "cores", - "buried", - "respect", - "center", - "hydrophobic", - "natural", - "surface", - "structure", - "three", + "contain", + "parent", + "toward", + "data", + "chemical", "fluorination", + "incorporation", + "increasing", + "bundle", + "hexafluoroleucine", + "replace", "either", - "increase", - "idea", - "nonfluorinated", - "formation", - "known", - "folding", - "packing", - "structural", - "contain" + "increase" ], "release_date":"2012-10-31", "publication":"\"Comparison of the structures and stabilities of coiled-coil proteins containing hexafluoroleucine and t-butylalanine provides insight into the stabilizing effects of highly fluorinated amino acid side-chains\", Protein Sci., 21, 1705-1715", @@ -76768,92 +76906,92 @@ ], "subtitle":"Crystal structure of engineered protein. northeast structural genomics consortium target or266", "tags":[ - "or266", - "northeast structural genomics consortium", "protein structure initiative", - "de novo protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", + "or266", "psi-biology" ], "keywords":[ - "cyclically", - "use", + "probe", + "repeat", "complexes", - "scattering", - "close", "idealized", "roles", - "experimentally", - "crystal", - "probe", + "newly", "assess", - "repeat", - "monomer", - "consistent", - "cyclic", - "direct", - "interfaces", + "new", + "model", + "protein", + "homotetramers", + "six", + "rapid", + "close", + "cyclically", "general", - "proteins", - "models", + "crystal", + "stable", + "corresponding", + "monodisperse", "play", - "designability", "characterized", + "formed", + "enumeration", + "experimentally", + "biological", + "consistent", + "cyclic", + "approach", + "proteins", + "use", + "scattering", "interface", - "ability", - "onto", - "structures", - "21", - "solution", - "corresponding", - "function", - "assembly", - "biology", - "form", - "rapid", - "data", - "obtained", - "newly", - "sufficiently", - "generate", - "report", + "found", + "15", + "monomer", "four", - "method", - "approaches", - "six", - "design", - "model", - "followed", - "96", + "sufficiently", + "computational", + "obtained", + "direct", "symmetry", + "design", + "onto", + "biology", + "assembly", + "designability", + "employs", + "solution", + "ability", "sequence", - "biological", "homotrimers", + "docked", + "96", + "method", "could", + "form", + "models", + "interfaces", + "custom", + "one", + "structures", + "approaches", + "21", "important", - "employs", + "possess", + "report", + "followed", + "function", + "homodimers", "homopentamer", - "designs", - "one", - "monodisperse", - "approach", - "stable", + "systematic", "enable", - "custom", - "found", + "data", "arrangements", - "systematic", - "protein", - "enumeration", - "possess", - "15", - "homodimers", - "docked", - "computational", - "homotetramers", - "formed", - "five", - "new" + "designs", + "generate", + "five" ], "release_date":"2012-08-29", "publication":"\"Computational design of self-assembling cyclic protein homo-oligomers\", NAT.CHEM., 9, 353-360", @@ -76966,11 +77104,11 @@ }, { "sim":186.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":186.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":186.0, @@ -77054,19 +77192,19 @@ }, { "sim":176.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":176.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":176.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":176.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":176.0, @@ -77074,35 +77212,35 @@ }, { "sim":176.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":176.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":176.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":176.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":176.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":176.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":176.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":176.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":175.0, @@ -77146,7 +77284,7 @@ }, { "sim":172.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":172.0, @@ -77154,7 +77292,7 @@ }, { "sim":172.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":171.0, @@ -77186,11 +77324,11 @@ }, { "sim":168.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":168.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":168.0, @@ -77218,11 +77356,15 @@ }, { "sim":140.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":140.0, - "partner":"7b4u" + "partner":"7b4v" + }, + { + "sim":138.0, + "partner":"9glq" }, { "sim":138.0, @@ -77316,11 +77458,11 @@ }, { "sim":167.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":167.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":139.0, @@ -77408,15 +77550,15 @@ }, { "sim":115.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":115.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":115.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":113.0, @@ -77588,11 +77730,11 @@ }, { "sim":81.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":81.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":77.0, @@ -77612,15 +77754,15 @@ }, { "sim":72.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":72.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":72.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":71.0, @@ -77673,6 +77815,10 @@ { "sim":51.0, "partner":"2vge" + }, + { + "sim":51.0, + "partner":"8ycp" } ], "struct_thr_sim_designed":[ @@ -77778,91 +77924,91 @@ ], "subtitle":"Crystal structure of engineered protein. northeast structural genomics consortium target or264", "tags":[ + "nesg", + "de novo protein", "northeast structural genomics consortium", "structural genomics", - "de novo protein", - "nesg", "psi-biology" ], "keywords":[ - "cyclically", - "use", + "probe", + "repeat", "complexes", - "scattering", - "close", "idealized", "roles", - "experimentally", - "crystal", - "probe", + "newly", "assess", - "repeat", - "monomer", - "consistent", - "cyclic", - "direct", - "interfaces", + "new", + "model", + "protein", + "homotetramers", + "six", + "rapid", + "close", + "cyclically", "general", - "proteins", - "models", + "crystal", + "stable", + "corresponding", + "monodisperse", "play", - "designability", "characterized", + "formed", + "enumeration", + "experimentally", + "biological", + "consistent", + "cyclic", + "approach", + "proteins", + "use", + "scattering", "interface", - "ability", - "onto", - "structures", - "21", - "solution", - "corresponding", - "function", - "assembly", - "biology", - "form", - "rapid", - "data", - "obtained", - "newly", - "sufficiently", - "generate", - "report", + "found", + "15", + "monomer", "four", - "method", - "approaches", - "six", - "design", - "model", - "followed", - "96", + "sufficiently", + "computational", + "obtained", + "direct", "symmetry", + "design", + "onto", + "biology", + "assembly", + "designability", + "employs", + "solution", + "ability", "sequence", - "biological", "homotrimers", + "docked", + "96", + "method", "could", + "form", + "models", + "interfaces", + "custom", + "one", + "structures", + "approaches", + "21", "important", - "employs", + "possess", + "report", + "followed", + "function", + "homodimers", "homopentamer", - "designs", - "one", - "monodisperse", - "approach", - "stable", + "systematic", "enable", - "custom", - "found", + "data", "arrangements", - "systematic", - "protein", - "enumeration", - "possess", - "15", - "homodimers", - "docked", - "computational", - "homotetramers", - "formed", - "five", - "new" + "designs", + "generate", + "five" ], "release_date":"2012-09-05", "publication":"\"Computational design of self-assembling cyclic protein homo-oligomers\", NAT.CHEM., 9, 353-360", @@ -78083,19 +78229,19 @@ }, { "sim":170.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":170.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":170.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":170.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":170.0, @@ -78103,35 +78249,35 @@ }, { "sim":170.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":170.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":170.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":170.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":170.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":170.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":170.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":170.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":169.0, @@ -78143,7 +78289,7 @@ }, { "sim":168.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":168.0, @@ -78151,7 +78297,7 @@ }, { "sim":168.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":168.0, @@ -78195,11 +78341,11 @@ }, { "sim":163.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":163.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":163.0, @@ -78223,11 +78369,11 @@ }, { "sim":135.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":135.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":134.0, @@ -78237,6 +78383,10 @@ "sim":133.0, "partner":"7z73" }, + { + "sim":131.0, + "partner":"9glq" + }, { "sim":130.0, "partner":"8aiw" @@ -78325,11 +78475,11 @@ }, { "sim":162.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":162.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":144.0, @@ -78425,15 +78575,15 @@ }, { "sim":112.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":112.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":112.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":111.0, @@ -78658,6 +78808,10 @@ { "sim":52.0, "partner":"2nyj" + }, + { + "sim":50.0, + "partner":"8ycp" } ], "struct_thr_sim_designed":[ @@ -78837,13 +78991,13 @@ ], "subtitle":"Three-dimensional structure of the de novo designed serine hydrolase 2bfq_3, northeast structural genomics consortium (nesg) target or248", "tags":[ - "hydrolase", - "structural genomics", "protein structure initiative", "de novo protein", + "hydrolase", + "structural genomics", + "northeast structural genomics consortium (nesg)", "psi-biology", - "de novo protein, hydrolase", - "northeast structural genomics consortium (nesg)" + "de novo protein, hydrolase" ], "keywords":[ "description", @@ -78950,12 +79104,12 @@ ], "subtitle":"Crystal structure of a parallel 4-helix coiled coil cc-hex-ii", "tags":[ + "c-terminal amidation", "none", - "de novo peptide", + "de novo protein", "n-terminal acetylation", - "c-terminal amidation", "4-helix coiled coil", - "de novo protein" + "de novo peptide" ], "keywords":[ "description", @@ -79193,10 +79347,10 @@ ], "subtitle":"Crystal structure of a parallel 4-helix coiled coil cc-hex-ii- 22", "tags":[ - "synthetic coiled coil peptide", - "cc-hex related", "de novo protein", - "n-terminal acetylation; c-terminal amidation" + "cc-hex related", + "n-terminal acetylation; c-terminal amidation", + "synthetic coiled coil peptide" ], "keywords":[ "description", @@ -79399,9 +79553,9 @@ "subtitle":"Crystal structure of a parallel 6-helix coiled coil cc-hex-il- 22", "tags":[ "de novo protein", + "c-terminal amidation", "spiral\/offset 6-straded coiled coil", - "n-terminal acetylation", - "c-terminal amidation" + "n-terminal acetylation" ], "keywords":[ "description", @@ -79442,33 +79596,25 @@ ], "struct_thr_sim_designed":[ - { - "sim":1.0, - "partner":"4h8f" - }, - { - "sim":1.0, - "partner":"6q5n" - }, { "sim":1.0, "partner":"6q5p" }, { "sim":1.0, - "partner":"4h7r" + "partner":"3r3k" }, { "sim":1.0, - "partner":"3r47" + "partner":"4h7r" }, { "sim":1.0, - "partner":"3r3k" + "partner":"4h8f" }, { "sim":1.0, - "partner":"3r48" + "partner":"6q5n" }, { "sim":1.0, @@ -79479,24 +79625,20 @@ "partner":"3r46" }, { - "sim":0.9593999982, - "partner":"6q5h" + "sim":1.0, + "partner":"3r48" }, { "sim":1.0, "partner":"6q5j" }, - { - "sim":0.9805999994, - "partner":"6q5o" - }, { "sim":1.0, "partner":"6q5s" }, { - "sim":0.9577000141, - "partner":"6q5i" + "sim":0.9805999994, + "partner":"6q5o" }, { "sim":1.0, @@ -79504,23 +79646,23 @@ }, { "sim":1.0, - "partner":"4dzn" + "partner":"6q5r" }, { - "sim":0.9563000202, - "partner":"5eoj" + "sim":1.0, + "partner":"4dzn" }, { "sim":1.0, - "partner":"6q5r" + "partner":"3r47" }, { - "sim":0.9575999975, - "partner":"5eon" + "sim":0.9563000202, + "partner":"5eoj" }, { - "sim":0.9991000295, - "partner":"4dzm" + "sim":0.9575999975, + "partner":"5vte" }, { "sim":0.9792000055, @@ -79528,24 +79670,24 @@ }, { "sim":0.9575999975, - "partner":"5vte" + "partner":"5eon" + }, + { + "sim":0.9991000295, + "partner":"4dzm" }, { "sim":1.0, "partner":"4dzl" }, { - "sim":1.0, - "partner":"4dzk" + "sim":0.9937000275, + "partner":"6i1j" }, { "sim":1.0, "partner":"8a3g" }, - { - "sim":0.9937000275, - "partner":"6i1j" - }, { "sim":1.0, "partner":"7qdk" @@ -79562,18 +79704,30 @@ "sim":1.0, "partner":"3r4a" }, - { - "sim":0.956099987, - "partner":"6v5j" - }, { "sim":0.9575999975, "partner":"5uxt" }, + { + "sim":0.956099987, + "partner":"6v5j" + }, { "sim":0.9534999728, "partner":"6v5i" }, + { + "sim":0.9593999982, + "partner":"6q5h" + }, + { + "sim":0.9577000141, + "partner":"6q5i" + }, + { + "sim":1.0, + "partner":"4dzk" + }, { "sim":0.9801999927, "partner":"6xy1" @@ -79655,12 +79809,12 @@ ], "subtitle":"Crystal structure of a parallel 6-helix coiled coil cc-hex-d24-a5\/7c", "tags":[ - "parallel", - "n-terminal acetylation", "c-terminal amidation", "de novo protein", - "hexameric coiled coil", - "cc-hex" + "n-terminal acetylation", + "cc-hex", + "parallel", + "hexameric coiled coil" ], "keywords":[ "description", @@ -79711,51 +79865,51 @@ }, { "sim":1.0, - "partner":"4h8o" + "partner":"6q5k" }, { "sim":1.0, - "partner":"6q5h" + "partner":"4h8o" }, { - "sim":0.9678999782, - "partner":"8bcs" + "sim":1.0, + "partner":"6q5j" }, { - "sim":1.0, - "partner":"6q5k" + "sim":0.9951000214, + "partner":"6q5l" }, { - "sim":1.0, - "partner":"3r47" + "sim":0.9963999987, + "partner":"6q5i" }, { - "sim":1.0, - "partner":"6q5n" + "sim":0.9710000157, + "partner":"6q5m" }, { "sim":1.0, - "partner":"3r3k" + "partner":"3r47" }, { "sim":1.0, - "partner":"3r46" + "partner":"6q5h" }, { - "sim":0.9951000214, - "partner":"6q5l" + "sim":1.0, + "partner":"6q5n" }, { - "sim":0.9710000157, - "partner":"6q5m" + "sim":1.0, + "partner":"3r3k" }, { - "sim":0.9963999987, - "partner":"6q5i" + "sim":0.9678999782, + "partner":"8bcs" }, { "sim":1.0, - "partner":"6q5j" + "partner":"3r46" }, { "sim":1.0, @@ -79773,49 +79927,57 @@ "sim":0.9983000159, "partner":"4h8f" }, - { - "sim":1.0, - "partner":"6q5s" - }, { "sim":0.9710000157, "partner":"6eiz" }, - { - "sim":0.9733999968, - "partner":"8a3g" - }, { "sim":0.9690999985, - "partner":"6q5r" + "partner":"3r4a" }, { - "sim":0.9690999985, - "partner":"3r4a" + "sim":0.9654999971, + "partner":"3r4h" }, { "sim":0.9710000157, "partner":"7qdk" }, + { + "sim":1.0, + "partner":"6q5s" + }, { "sim":0.9733999968, - "partner":"6xy0" + "partner":"4pn9" }, { - "sim":0.9745000005, - "partner":"6q5o" + "sim":0.9733999968, + "partner":"8a3g" + }, + { + "sim":0.9508000016, + "partner":"6g6d" }, { "sim":0.9733999968, - "partner":"4pn9" + "partner":"6xy0" + }, + { + "sim":0.9733999968, + "partner":"6xy1" }, { "sim":0.9745000005, "partner":"6q5q" }, { - "sim":0.9733999968, - "partner":"6xy1" + "sim":0.9745000005, + "partner":"6q5o" + }, + { + "sim":0.9505000114, + "partner":"7bim" }, { "sim":0.9733999968, @@ -79825,25 +79987,17 @@ "sim":0.9505000114, "partner":"7a1t" }, - { - "sim":0.9505000114, - "partner":"7baw" - }, { "sim":0.9505000114, "partner":"8b16" }, { "sim":0.9505000114, - "partner":"7bim" - }, - { - "sim":0.9654999971, - "partner":"3r4h" + "partner":"7baw" }, { - "sim":0.9508000016, - "partner":"6g6d" + "sim":0.9690999985, + "partner":"6q5r" } ], "struct_thr_sim_natural":[ @@ -79918,13 +80072,13 @@ ], "subtitle":"Crystal structure of a parallel 6-helix coiled coil cc-hex-h24-a5\/7c", "tags":[ - "parallel", - "6-stranded coiled coil", "disulfide bonds", - "n-terminal acetylation", "c-terminal amidation", + "6-stranded coiled coil", "de novo protein", - "cc-hex" + "n-terminal acetylation", + "cc-hex", + "parallel" ], "keywords":[ "description", @@ -80170,12 +80324,12 @@ ], "subtitle":"Crystal structure of a parallel 6-helix coiled coil cc-hex-n24", "tags":[ - "parallel", - "n-terminal acetylation", "c-terminal amidation", "de novo protein", - "hexameric coiled coil", - "cc-hex" + "n-terminal acetylation", + "cc-hex", + "parallel", + "hexameric coiled coil" ], "keywords":[ "description", @@ -80400,77 +80554,77 @@ "designed helical bundle" ], "keywords":[ - "rapid", - "exchange", - "seven", + "reveal", + "designed", + "tertiary", + "c", "analysis", - "unfolding", - "monomeric", - "indicating", - "amide", - "amino", - "functional", - "proteins", - "unique", - "factors", - "higher", - "25", - "concentration", - "stable", - "resolution", - "four", - "acid", - "experiments", - "thermodynamic", + "order", + "energy", "6", - "fold", - "1", - "acids", - "designed", - "alphabet", - "constructed", + "resolution", + "rather", + "undertaken", + "provides", "well", - "10", - "reveal", + "excess", + "functional", "due", - "crystal", + "mm", "3", - "folded", - "provides", - "confirms", - "bundle", - "undertaken", - "order", - "reduced", - "protein", + "kcal", + "amide", + "free", + "structure", + "monomeric", + "acid", + "helix", + "factors", + "indicating", + "fold", + "experiments", + "characteristic", + "folding", + "quaternary", "108", + "degrees", + "protein", "buried", - "8", - "rather", - "2", - "kcal", "estimate", - "degrees", + "folded", "derived", + "amino", + "25", "required", - "helix", - "structure", - "tertiary", - "c", - "protection", - "protons", - "energy", - "mm", - "excess", + "reduced", + "constructed", + "proteins", "x", + "rapid", + "unfolding", + "confirms", "protected", - "quaternary", - "free", - "folding", - "consistent", + "concentration", + "thermodynamic", + "2", + "alphabet", + "seven", + "exchange", + "acids", + "crystal", + "protection", + "stable", + "range", + "four", + "unique", + "8", + "10", + "higher", "global", - "characteristic", - "range" + "bundle", + "protons", + "1", + "consistent" ], "release_date":"1998-03-04", "publication":"\"A designed four helix bundle protein with native-like structure\", Nat.Struct.Biol., 4, 1039-1046", @@ -80606,91 +80760,91 @@ ], "subtitle":"Crystal structure of engineered protein. northeast structural genomics consortium target or267", "tags":[ - "structural genomics", - "protein structure initiative", "de novo protein", "psi-biology", - "northeast structural genomics consortium (nesg)" + "structural genomics", + "northeast structural genomics consortium (nesg)", + "protein structure initiative" ], "keywords":[ - "cyclically", - "use", + "probe", + "repeat", "complexes", - "scattering", - "close", "idealized", "roles", - "experimentally", - "crystal", - "probe", + "newly", "assess", - "repeat", - "monomer", - "consistent", - "cyclic", - "direct", - "interfaces", + "new", + "model", + "protein", + "homotetramers", + "six", + "rapid", + "close", + "cyclically", "general", - "proteins", - "models", + "crystal", + "stable", + "corresponding", + "monodisperse", "play", - "designability", "characterized", + "formed", + "enumeration", + "experimentally", + "biological", + "consistent", + "cyclic", + "approach", + "proteins", + "use", + "scattering", "interface", - "ability", - "onto", - "structures", - "21", - "solution", - "corresponding", - "function", - "assembly", - "biology", - "form", - "rapid", - "data", - "obtained", - "newly", - "sufficiently", - "generate", - "report", + "found", + "15", + "monomer", "four", - "method", - "approaches", - "six", - "design", - "model", - "followed", - "96", + "sufficiently", + "computational", + "obtained", + "direct", "symmetry", + "design", + "onto", + "biology", + "assembly", + "designability", + "employs", + "solution", + "ability", "sequence", - "biological", "homotrimers", + "docked", + "96", + "method", "could", + "form", + "models", + "interfaces", + "custom", + "one", + "structures", + "approaches", + "21", "important", - "employs", + "possess", + "report", + "followed", + "function", + "homodimers", "homopentamer", - "designs", - "one", - "monodisperse", - "approach", - "stable", + "systematic", "enable", - "custom", - "found", + "data", "arrangements", - "systematic", - "protein", - "enumeration", - "possess", - "15", - "homodimers", - "docked", - "computational", - "homotetramers", - "formed", - "five", - "new" + "designs", + "generate", + "five" ], "release_date":"2012-10-10", "publication":"\"Computational design of self-assembling cyclic protein homo-oligomers\", NAT.CHEM., 9, 353-360", @@ -80887,19 +81041,19 @@ }, { "sim":168.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":168.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":168.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":168.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":168.0, @@ -80907,43 +81061,43 @@ }, { "sim":168.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":168.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":168.0, - "partner":"7dnf" + "partner":"8qlb" }, { "sim":168.0, - "partner":"8ql6" + "partner":"8ql9" }, { "sim":168.0, - "partner":"8ql5" + "partner":"7dnf" }, { "sim":168.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":168.0, - "partner":"8ql7" + "partner":"7dng" }, { "sim":168.0, - "partner":"8qlb" + "partner":"8ql4" }, { "sim":168.0, - "partner":"7dng" + "partner":"8ql2" }, { "sim":168.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":168.0, @@ -80975,7 +81129,7 @@ }, { "sim":166.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":166.0, @@ -80983,7 +81137,7 @@ }, { "sim":166.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":166.0, @@ -81019,11 +81173,11 @@ }, { "sim":161.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":161.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":161.0, @@ -81055,16 +81209,20 @@ }, { "sim":132.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":132.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":131.0, "partner":"8ak1" }, + { + "sim":130.0, + "partner":"9glq" + }, { "sim":128.0, "partner":"8aiw" @@ -81153,11 +81311,11 @@ }, { "sim":159.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":159.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":139.0, @@ -81245,15 +81403,15 @@ }, { "sim":116.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":116.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":116.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":113.0, @@ -81405,11 +81563,11 @@ }, { "sim":82.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":82.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":82.0, @@ -81453,15 +81611,15 @@ }, { "sim":72.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":72.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":72.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":68.0, @@ -81602,12 +81760,12 @@ ], "subtitle":"Crystal structure of engineered protein. northeast structural genomics consortium target or265", "tags":[ + "engineered protein", + "nesg", + "de novo protein", "northeast structural genomics consortium", "structural genomics", - "de novo protein", - "nesg", - "psi-biology", - "engineered protein" + "psi-biology" ], "keywords":[ "description", @@ -81656,11 +81814,11 @@ }, { "sim":271.0, - "partner":"5kba" + "partner":"5hry" }, { "sim":271.0, - "partner":"5hry" + "partner":"5kba" }, { "sim":261.0, @@ -81824,19 +81982,19 @@ }, { "sim":175.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":175.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":175.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":175.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":175.0, @@ -81844,35 +82002,35 @@ }, { "sim":175.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":175.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":175.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":175.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":175.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":175.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":175.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":175.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":174.0, @@ -81884,7 +82042,7 @@ }, { "sim":174.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":174.0, @@ -81892,7 +82050,7 @@ }, { "sim":174.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":173.0, @@ -81940,11 +82098,11 @@ }, { "sim":169.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":169.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":169.0, @@ -81976,16 +82134,20 @@ }, { "sim":136.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":136.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":134.0, "partner":"8aiw" }, + { + "sim":134.0, + "partner":"9glq" + }, { "sim":133.0, "partner":"7z73" @@ -82074,11 +82236,11 @@ }, { "sim":164.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":164.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":143.0, @@ -82174,15 +82336,15 @@ }, { "sim":115.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":115.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":115.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":110.0, @@ -82520,92 +82682,92 @@ ], "subtitle":"Crystal structure of engineered protein. northeast structural genomics consortium target or329", "tags":[ + "nesg", + "de novo protein", "northeast structural genomics consortium", + "psi-biology", "structural genomics", - "protein structure initiative", - "de novo protein", - "nesg", - "psi-biology" + "protein structure initiative" ], "keywords":[ - "cyclically", - "use", + "probe", + "repeat", "complexes", - "scattering", - "close", "idealized", "roles", - "experimentally", - "crystal", - "probe", + "newly", "assess", - "repeat", - "monomer", - "consistent", - "cyclic", - "direct", - "interfaces", + "new", + "model", + "protein", + "homotetramers", + "six", + "rapid", + "close", + "cyclically", "general", - "proteins", - "models", + "crystal", + "stable", + "corresponding", + "monodisperse", "play", - "designability", "characterized", + "formed", + "enumeration", + "experimentally", + "biological", + "consistent", + "cyclic", + "approach", + "proteins", + "use", + "scattering", "interface", - "ability", - "onto", - "structures", - "21", - "solution", - "corresponding", - "function", - "assembly", - "biology", - "form", - "rapid", - "data", - "obtained", - "newly", - "sufficiently", - "generate", - "report", + "found", + "15", + "monomer", "four", - "method", - "approaches", - "six", - "design", - "model", - "followed", - "96", + "sufficiently", + "computational", + "obtained", + "direct", "symmetry", + "design", + "onto", + "biology", + "assembly", + "designability", + "employs", + "solution", + "ability", "sequence", - "biological", "homotrimers", + "docked", + "96", + "method", "could", + "form", + "models", + "interfaces", + "custom", + "one", + "structures", + "approaches", + "21", "important", - "employs", + "possess", + "report", + "followed", + "function", + "homodimers", "homopentamer", - "designs", - "one", - "monodisperse", - "approach", - "stable", + "systematic", "enable", - "custom", - "found", + "data", "arrangements", - "systematic", - "protein", - "enumeration", - "possess", - "15", - "homodimers", - "docked", - "computational", - "homotetramers", - "formed", - "five", - "new" + "designs", + "generate", + "five" ], "release_date":"2012-11-21", "publication":"\"Computational design of self-assembling cyclic protein homo-oligomers\", NAT.CHEM., 9, 353-360", @@ -82684,7 +82846,7 @@ }, { "sim":131.0, - "partner":"3q5u" + "partner":"3knd" }, { "sim":131.0, @@ -82692,11 +82854,11 @@ }, { "sim":131.0, - "partner":"3knd" + "partner":"1ejy" }, { "sim":131.0, - "partner":"1ejy" + "partner":"1pjm" }, { "sim":131.0, @@ -82704,11 +82866,11 @@ }, { "sim":131.0, - "partner":"1pjm" + "partner":"1pjn" }, { "sim":131.0, - "partner":"1pjn" + "partner":"3q5u" }, { "sim":131.0, @@ -82718,14 +82880,6 @@ "sim":131.0, "partner":"1q1t" }, - { - "sim":131.0, - "partner":"3rzx" - }, - { - "sim":131.0, - "partner":"3oqs" - }, { "sim":131.0, "partner":"3ukw" @@ -82757,6 +82911,14 @@ { "sim":131.0, "partner":"3uvu" + }, + { + "sim":131.0, + "partner":"3rzx" + }, + { + "sim":131.0, + "partner":"3oqs" } ], "struct_thr_sim_designed":[ @@ -82870,13 +83032,13 @@ ], "subtitle":"Crystal structure of engineered protein, northeast structural genomics consortium target or288", "tags":[ - "northeast structural genomics consortium", - "structural genomics", - "protein structure initiative", - "de novo protein", + "engineered protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", "psi-biology", - "engineered protein" + "structural genomics", + "protein structure initiative" ], "keywords":[ "description", @@ -82975,11 +83137,11 @@ }, { "sim":444.0, - "partner":"1a53" + "partner":"1lbl" }, { "sim":444.0, - "partner":"1lbl" + "partner":"1a53" }, { "sim":444.0, @@ -83136,8 +83298,8 @@ ], "subtitle":"Crystal structure of qklvffaed nonapeptide segment from amyloid beta incorporated into a macrocyclic beta-sheet template", "tags":[ - "amyloid oligomer", - "de novo protein" + "de novo protein", + "amyloid oligomer" ], "keywords":[ "description", @@ -83272,14 +83434,14 @@ ], "subtitle":"Crystal structure of the improved variant of the evolved serine hydrolase, osh55.4_h1.2, bond with sulfate ion in the active site, northeast structural genomics consortium (nesg) target or301", "tags":[ - "serine hydrolase", "northeast structural genomics consortium (nesg) target or301", - "osh55.4_h1.2", - "structural genomics", "protein structure initiative", "unknown function", - "psi-biology", - "structural genomics, unknown function" + "osh55.4_h1.2", + "structural genomics", + "structural genomics, unknown function", + "serine hydrolase", + "psi-biology" ], "keywords":[ "description", @@ -83467,117 +83629,117 @@ ], "subtitle":"E3_5 darpin l86a mutant", "tags":[ - "darpins", "unselected darpin", "ankyrin repeat protein", "de novo protein", + "darpins", "protein design" ], "keywords":[ - "pools", - "work", - "containing", - "monomeric", - "providing", - "thus", - "describes", + "hydrophobic", + "diversified", + "structural", + "repeat", + "number", + "key", "complexes", - "tyrosines", - "scaffolds", + "randomized", + "13", + "side", "roles", - "designed", - "generated", - "acrb", - "crystal", - "target", - "based", - "enriched", - "caspases", - "synthetic", - "structure", + "extended", + "tryptophans", + "new", + "increased", + "positions", + "binding", "representative", - "display", - "repeat", + "unspecific", + "counteract", + "original", + "two", "nonantibody", - "building", - "tryptophans", + "crystal", + "stable", + "chains", + "leucine", + "complex", + "ribosome", + "thus", + "residues", + "protocol", + "targets", + "polar", + "library", + "surfaces", + "substitute", "contacts", - "aromatic", - "enrichment", - "original", + "stability", "proteins", - "membrane", - "unique", - "phenylalanine", + "mutants", + "valine", + "ankyrin", + "noted", + "visualizes", "binder", - "number", - "yielded", - "tryptophan", + "scaffold", "highly", - "difficult", - "binders", - "visualizes", - "structures", - "positions", - "simplifies", - "assembly", - "methionine", - "mutants", + "enrichment", + "required", "measurements", - "molecules", - "diversified", - "stability", - "drastically", - "randomized", + "surface", + "mainly", + "prominent", + "work", + "binders", "selections", - "extended", - "noted", - "unspecific", + "diverse", + "display", "apolar", - "increased", - "darpins", - "strong", - "mainly", - "surfaces", - "protocol", - "leucine", + "assembly", + "simplifies", + "isoleucine", "reduced", - "hydrophobic", - "required", - "existing", - "surface", - "transporter", - "key", - "structural", - "13", - "library", - "diverse", - "chains", + "describes", + "frequency", + "building", "substituted", - "substitute", - "valine", + "unique", "analyses", - "stable", - "ribosome", - "human", - "ankyrin", - "residues", + "darpins", + "enriched", + "designed", + "strong", + "aromatic", + "phenylalanine", + "providing", + "structures", + "caspases", + "tyrosines", + "based", "darpin", - "two", - "frequency", - "counteract", - "polar", - "scaffold", - "isoleucine", - "targets", - "complex", - "extend", - "prominent", - "side", - "binding", + "methionine", + "structure", + "monomeric", + "synthetic", + "scaffolds", + "transporter", + "target", "biophysical", + "membrane", + "molecules", + "yielded", + "drastically", + "pools", + "tryptophan", + "generated", + "difficult", + "extend", "libraries", - "new" + "existing", + "human", + "acrb", + "containing" ], "release_date":"2013-08-14", "publication":"\"Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity\", Protein Sci., 22, 1239-1257", @@ -83614,19 +83776,19 @@ }, { "sim":297.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":297.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":297.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":297.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":297.0, @@ -83634,35 +83796,35 @@ }, { "sim":297.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":297.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":297.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":297.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":297.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":297.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":297.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":297.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":295.0, @@ -83698,11 +83860,11 @@ }, { "sim":280.0, - "partner":"4ydw" + "partner":"5kng" }, { "sim":280.0, - "partner":"5kng" + "partner":"4ydw" }, { "sim":280.0, @@ -83806,7 +83968,7 @@ }, { "sim":255.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":255.0, @@ -83814,7 +83976,7 @@ }, { "sim":255.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":254.0, @@ -83866,11 +84028,11 @@ }, { "sim":230.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":230.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":230.0, @@ -83918,11 +84080,11 @@ }, { "sim":196.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":196.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":192.0, @@ -83956,6 +84118,10 @@ "sim":185.0, "partner":"4hb5" }, + { + "sim":184.0, + "partner":"9glq" + }, { "sim":179.0, "partner":"5hry" @@ -84040,11 +84206,11 @@ }, { "sim":255.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":255.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":231.0, @@ -84144,15 +84310,15 @@ }, { "sim":107.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":107.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":107.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":106.0, @@ -84176,15 +84342,15 @@ }, { "sim":104.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":104.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":104.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":102.0, @@ -84344,11 +84510,11 @@ }, { "sim":78.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":78.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":77.0, @@ -84408,15 +84574,15 @@ }, { "sim":65.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":65.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":65.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":65.0, @@ -84470,6 +84636,10 @@ "sim":55.0, "partner":"2nyj" }, + { + "sim":54.0, + "partner":"8ycp" + }, { "sim":52.0, "partner":"3ljn" @@ -84667,117 +84837,117 @@ ], "subtitle":"E3_5 darpin d77s mutant", "tags":[ - "ankyrin repeat", - "darpins", "unselected darpin", "de novo protein", - "protein design" + "darpins", + "protein design", + "ankyrin repeat" ], "keywords":[ - "pools", - "work", - "containing", - "monomeric", - "providing", - "thus", - "describes", + "hydrophobic", + "diversified", + "structural", + "repeat", + "number", + "key", "complexes", - "tyrosines", - "scaffolds", + "randomized", + "13", + "side", "roles", - "designed", - "generated", - "acrb", - "crystal", - "target", - "based", - "enriched", - "caspases", - "synthetic", - "structure", + "extended", + "tryptophans", + "new", + "increased", + "positions", + "binding", "representative", - "display", - "repeat", + "unspecific", + "counteract", + "original", + "two", "nonantibody", - "building", - "tryptophans", + "crystal", + "stable", + "chains", + "leucine", + "complex", + "ribosome", + "thus", + "residues", + "protocol", + "targets", + "polar", + "library", + "surfaces", + "substitute", "contacts", - "aromatic", - "enrichment", - "original", + "stability", "proteins", - "membrane", - "unique", - "phenylalanine", + "mutants", + "valine", + "ankyrin", + "noted", + "visualizes", "binder", - "number", - "yielded", - "tryptophan", + "scaffold", "highly", - "difficult", - "binders", - "visualizes", - "structures", - "positions", - "simplifies", - "assembly", - "methionine", - "mutants", + "enrichment", + "required", "measurements", - "molecules", - "diversified", - "stability", - "drastically", - "randomized", + "surface", + "mainly", + "prominent", + "work", + "binders", "selections", - "extended", - "noted", - "unspecific", + "diverse", + "display", "apolar", - "increased", - "darpins", - "strong", - "mainly", - "surfaces", - "protocol", - "leucine", + "assembly", + "simplifies", + "isoleucine", "reduced", - "hydrophobic", - "required", - "existing", - "surface", - "transporter", - "key", - "structural", - "13", - "library", - "diverse", - "chains", + "describes", + "frequency", + "building", "substituted", - "substitute", - "valine", + "unique", "analyses", - "stable", - "ribosome", - "human", - "ankyrin", - "residues", + "darpins", + "enriched", + "designed", + "strong", + "aromatic", + "phenylalanine", + "providing", + "structures", + "caspases", + "tyrosines", + "based", "darpin", - "two", - "frequency", - "counteract", - "polar", - "scaffold", - "isoleucine", - "targets", - "complex", - "extend", - "prominent", - "side", - "binding", + "methionine", + "structure", + "monomeric", + "synthetic", + "scaffolds", + "transporter", + "target", "biophysical", + "membrane", + "molecules", + "yielded", + "drastically", + "pools", + "tryptophan", + "generated", + "difficult", + "extend", "libraries", - "new" + "existing", + "human", + "acrb", + "containing" ], "release_date":"2013-08-14", "publication":"\"Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity\", Protein Sci., 22, 1239-1257", @@ -84814,19 +84984,19 @@ }, { "sim":297.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":297.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":297.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":297.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":297.0, @@ -84834,35 +85004,35 @@ }, { "sim":297.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":297.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":297.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":297.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":297.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":297.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":297.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":297.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":295.0, @@ -85010,7 +85180,7 @@ }, { "sim":254.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":254.0, @@ -85018,7 +85188,7 @@ }, { "sim":254.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":253.0, @@ -85058,11 +85228,11 @@ }, { "sim":230.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":230.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":230.0, @@ -85118,11 +85288,11 @@ }, { "sim":196.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":196.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":192.0, @@ -85152,6 +85322,10 @@ "sim":185.0, "partner":"4gpm" }, + { + "sim":184.0, + "partner":"9glq" + }, { "sim":183.0, "partner":"4hb5" @@ -85240,11 +85414,11 @@ }, { "sim":255.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":255.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":232.0, @@ -85356,15 +85530,15 @@ }, { "sim":106.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":106.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":106.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":102.0, @@ -85556,11 +85730,11 @@ }, { "sim":78.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":78.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":77.0, @@ -85612,15 +85786,15 @@ }, { "sim":64.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":64.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":64.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":64.0, @@ -85658,6 +85832,10 @@ "sim":59.0, "partner":"4bet" }, + { + "sim":57.0, + "partner":"8ycp" + }, { "sim":56.0, "partner":"3deo" @@ -85940,14 +86118,14 @@ ], "subtitle":"Crystal structure of the computationally designed serine hydrolase 3mmj_2, northeast structural genomics consortium (nesg) target or318", "tags":[ - "serine hydrolase", - "northeast structural genomics consortium", - "structural genomics", "protein structure initiative", - "unknown function", "nesg", - "psi-biology", - "structural genomics, unknown function" + "northeast structural genomics consortium", + "unknown function", + "structural genomics", + "structural genomics, unknown function", + "serine hydrolase", + "psi-biology" ], "keywords":[ "description", @@ -86017,10 +86195,6 @@ "sim":637.0, "partner":"2b4o" }, - { - "sim":637.0, - "partner":"2pt0" - }, { "sim":637.0, "partner":"3d1o" @@ -86037,6 +86211,10 @@ "sim":637.0, "partner":"2psz" }, + { + "sim":637.0, + "partner":"2pt0" + }, { "sim":634.0, "partner":"2b4p" @@ -86235,86 +86413,86 @@ ], "subtitle":"Crystal structure of a designed respiratory syncytial virus immunogen in complex with motavizumab", "tags":[ - "antibody", "immune system", "designed immunogen", + "specific binding", "rsv f protein", - "specific binding" + "antibody" ], "keywords":[ - "neutralization", - "hence", - "prevent", + "induce", + "encourage", + "variable", "largely", - "elderly", - "cases", + "disease", + "thermally", + "design", "strategies", - "induce", + "development", + "targeted", + "evaluation", + "show", + "methods", + "influenza", + "immunodeficiency", + "traditional", + "research", + "represent", + "hence", + "vaccines", + "prevent", + "epitopes", + "conformationally", + "identified", + "respiratory", + "structure", + "mimic", + "scaffolds", + "leads", "results", - "syncytial", + "provide", + "although", + "new", "virus", - "viral", + "targets", + "protective", "vulnerable", - "protect", - "respiratory", - "neutralizing", - "inducing", - "generate", - "accurately", - "potent", - "stable", - "although", - "principle", - "scaffolds", - "human", - "including", + "protein", + "cases", + "syncytial", "pathogens", - "encourage", - "young", - "antigenically", - "influenza", - "small", - "highly", - "needed", - "targeted", - "provide", - "variable", - "resisted", - "identified", - "methods", - "evaluation", "generally", "infectious", - "several", - "show", - "design", "infants", + "young", + "several", + "viral", "children", - "mimic", - "protein", - "targets", - "variety", - "development", - "represent", - "structure", "promising", - "thermally", - "conformationally", - "epitopes", + "including", + "highly", + "neutralization", + "small", + "neutralizing", + "proof", + "accurately", + "major", + "principle", + "elderly", + "variety", + "potent", + "protect", + "stable", "vaccine", + "human", + "inducing", + "resisted", "computational", - "vaccines", - "research", - "leads", "epitope", - "proof", - "major", + "antigenically", + "generate", "antibodies", - "immunodeficiency", - "disease", - "protective", - "traditional", - "new" + "needed" ], "release_date":"2014-02-05", "publication":"\"Proof of principle for epitope-focused vaccine design\", Nature, 507, 201-206", @@ -86442,120 +86620,120 @@ ], "subtitle":"Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alpharep)", "tags":[ + "de novo protein\/protein binding", "de novo protein-protein binding complex", "proteins engineered to bind to various partners", - "de novo protein\/protein binding", "alpha-helical proteins" ], "keywords":[ - "thermal", - "independent", - "results", - "long", - "established", - "complexes", - "suggest", - "modules", - "including", - "designed", + "relatively", + "repeats", + "optimized", "helicoidal", - "variable", - "improved", - "contains", - "crystal", - "target", - "based", - "instead", - "show", - "sequences", - "versatile", - "position", - "assembled", - "therefore", - "display", - "diversity", - "clones", - "favorable", - "recombined", - "thermostable", - "interfaces", "7", - "proteins", - "solved", - "process", - "source", - "family", "number", - "cognate", - "distribution", - "used", - "ranges", - "binders", + "show", + "thermostable", + "therefore", + "complexes", + "well", + "randomized", + "side", + "results", + "new", + "assembled", + "various", + "protein", "vary", - "codons", + "source", + "binding", "fully", - "coding", + "stabilization", + "recombined", + "two", "procedure", - "nanomolar", - "structures", - "recreate", - "natural", - "repeated", - "previously", - "properties", - "predefined", - "randomized", - "large", - "phage", - "subgroup", - "associated", - "ranging", - "four", - "artificial", - "surfaces", - "9", - "specific", + "crystal", + "chains", "using", - "sequence", - "repeats", "encoded", - "formation", + "construction", + "select", + "kd", + "final", + "distribution", + "clones", + "ranges", "selected", - "stabilization", + "residues", + "specific", + "family", + "coding", + "targets", "library", - "final", - "chains", - "construction", - "values", - "optimized", - "micromolar", + "surfaces", + "thermal", + "case", + "bound", + "proteins", + "large", + "modules", + "process", "described", - "retain", + "contains", + "\u03b1rep", + "established", + "suggest", + "four", + "micromolar", + "nanomolar", "tight", - "sizes", + "long", + "recreate", + "including", + "values", + "variable", + "retain", + "binders", + "instead", + "used", "named", - "select", - "well", + "natural", + "display", "different", - "residues", - "affinities", - "two", - "frequency", - "significant", - "filtration", - "protein", - "bound", - "\u03b1rep", - "targets", - "kd", - "relatively", - "various", + "sizes", + "properties", + "diversity", "polymerization", - "side", - "case", - "binding", + "subgroup", + "independent", + "9", + "improved", + "filtration", + "formation", + "frequency", + "sequence", + "solved", + "versatile", + "repeated", + "associated", + "designed", + "cognate", + "sequences", + "interfaces", + "structures", + "ranging", + "previously", + "based", + "predefined", + "target", "biophysical", - "new" + "codons", + "artificial", + "phage", + "favorable", + "position", + "affinities", + "significant" ], "release_date":"2013-09-25", "publication":"\"Selection of Specific Protein Binders for Pre-Defined Targets from an Optimized Library of Artificial Helicoidal Repeat Proteins (alphaRep)\", Plos One, 8, e71512-e71512", @@ -86586,29 +86764,29 @@ "previous_design":"4jlr", "next_design":"4jw3", "seq_thr_sim_designed":[ - { - "sim":225.0, - "partner":"4jw3" - }, { "sim":400.0, "partner":"3ltj" }, { - "sim":293.0, - "partner":"4zv6" + "sim":371.0, + "partner":"3ltm" }, { "sim":293.0, "partner":"6bzx" }, { - "sim":371.0, - "partner":"3ltm" + "sim":293.0, + "partner":"4zv6" }, { "sim":284.0, "partner":"6veh" + }, + { + "sim":225.0, + "partner":"4jw3" } ], "seq_thr_sim_natural":[ @@ -86718,121 +86896,121 @@ ], "subtitle":"Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alpharep)", "tags":[ - "alpha-helical protein", + "dna binding protein\/de novo protein", "ncs 3tes24 variant", + "protein engineered to interact with protein of interest", "dna binding protein-de novo protein complex", - "dna binding protein\/de novo protein", - "protein engineered to interact with protein of interest" + "alpha-helical protein" ], "keywords":[ - "thermal", - "independent", - "results", - "long", - "established", - "complexes", - "suggest", - "modules", - "including", - "designed", + "relatively", + "repeats", + "optimized", "helicoidal", - "variable", - "improved", - "contains", - "crystal", - "target", - "based", - "instead", - "show", - "sequences", - "versatile", - "position", - "assembled", - "therefore", - "display", - "diversity", - "clones", - "favorable", - "recombined", - "thermostable", - "interfaces", "7", - "proteins", - "solved", - "process", - "source", - "family", "number", - "cognate", - "distribution", - "used", - "ranges", - "binders", + "show", + "thermostable", + "therefore", + "complexes", + "well", + "randomized", + "side", + "results", + "new", + "assembled", + "various", + "protein", "vary", - "codons", + "source", + "binding", "fully", - "coding", + "stabilization", + "recombined", + "two", "procedure", - "nanomolar", - "structures", - "recreate", - "natural", - "repeated", - "previously", - "properties", - "predefined", - "randomized", - "large", - "phage", - "subgroup", - "associated", - "ranging", - "four", - "artificial", - "surfaces", - "9", - "specific", + "crystal", + "chains", "using", - "sequence", - "repeats", "encoded", - "formation", + "construction", + "select", + "kd", + "final", + "distribution", + "clones", + "ranges", "selected", - "stabilization", + "residues", + "specific", + "family", + "coding", + "targets", "library", - "final", - "chains", - "construction", - "values", - "optimized", - "micromolar", + "surfaces", + "thermal", + "case", + "bound", + "proteins", + "large", + "modules", + "process", "described", - "retain", + "contains", + "\u03b1rep", + "established", + "suggest", + "four", + "micromolar", + "nanomolar", "tight", - "sizes", + "long", + "recreate", + "including", + "values", + "variable", + "retain", + "binders", + "instead", + "used", "named", - "select", - "well", + "natural", + "display", "different", - "residues", - "affinities", - "two", - "frequency", - "significant", - "filtration", - "protein", - "bound", - "\u03b1rep", - "targets", - "kd", - "relatively", - "various", + "sizes", + "properties", + "diversity", "polymerization", - "side", - "case", - "binding", + "subgroup", + "independent", + "9", + "improved", + "filtration", + "formation", + "frequency", + "sequence", + "solved", + "versatile", + "repeated", + "associated", + "designed", + "cognate", + "sequences", + "interfaces", + "structures", + "ranging", + "previously", + "based", + "predefined", + "target", "biophysical", - "new" + "codons", + "artificial", + "phage", + "favorable", + "position", + "affinities", + "significant" ], "release_date":"2013-09-25", "publication":"\"Selection of Specific Protein Binders for Pre-Defined Targets from an Optimized Library of Artificial Helicoidal Repeat Proteins (alphaRep)\", Plos One, 8, e71512-e71512", @@ -86877,11 +87055,11 @@ }, { "sim":190.0, - "partner":"4zv6" + "partner":"6bzx" }, { "sim":190.0, - "partner":"6bzx" + "partner":"4zv6" }, { "sim":168.0, @@ -87040,13 +87218,13 @@ ], "subtitle":"Directed evolution and rational design of a de novo designed esterase toward improved catalysis. northeast structural genomics consortium (nesg) target or184", "tags":[ - "northeast structural genomics consortium", - "structural genomics", "protein structure initiative", - "unknown function", "nesg", - "psi-biology", - "structural genomics, unknown function" + "northeast structural genomics consortium", + "unknown function", + "structural genomics", + "structural genomics, unknown function", + "psi-biology" ], "keywords":[ "description", @@ -87129,15 +87307,15 @@ }, { "sim":60.0, - "partner":"2z8f" + "partner":"2z8d" }, { "sim":60.0, - "partner":"2z8d" + "partner":"2z8e" }, { "sim":60.0, - "partner":"2z8e" + "partner":"2z8f" }, { "sim":57.0, @@ -87149,11 +87327,11 @@ }, { "sim":51.0, - "partner":"2i58" + "partner":"2hq0" }, { "sim":51.0, - "partner":"2hq0" + "partner":"2i58" }, { "sim":51.0, @@ -87279,13 +87457,13 @@ ], "subtitle":"Crystal structure of the computationally designed serine hydrolase. northeast structural genomics consortium (nesg) target or317", "tags":[ - "northeast structural genomics consortium", - "structural genomics", "protein structure initiative", - "unknown function", "nesg", - "psi-biology", - "structural genomics, unknown function" + "northeast structural genomics consortium", + "unknown function", + "structural genomics", + "structural genomics, unknown function", + "psi-biology" ], "keywords":[ "description", @@ -87510,76 +87688,76 @@ ], "subtitle":"Three-dimensional structure of the orthorhombic crystal of computationally designed insertion domain , northeast structural genomics consortium (nesg) target or327", "tags":[ + "nesg", + "de novo protein", "northeast structural genomics consortium", + "psi-biology", "structural genomics", - "protein structure initiative", - "de novo protein", - "nesg", - "psi-biology" + "protein structure initiative" ], "keywords":[ - "interfaces", - "containing", - "domain", - "demonstrate", - "evolution", - "poses", - "designs", + "designed", + "form", + "complex", + "alternative", + "models", + "limited", + "design", + "beta", "one", - "matches", + "interfaces", "another", - "amino", - "models", - "large", - "newly", + "number", + "formed", + "fusion", + "poses", "merged", - "presumably", - "similar", - "extended", + "structures", "de", - "novo", "single", - "challenge", + "natural", + "domain", + "different", + "newly", + "extended", + "acid", "sheet", - "connectivities", + "matches", + "insertion", + "closely", + "protein", + "followed", "topologies", - "acid", + "six", + "amino", "optimization", - "designed", - "number", - "emergence", + "yield", + "large", + "packing", + "searches", + "sheets", + "contributed", "may", - "different", - "closely", + "novo", + "scop", + "demonstrate", + "sequence", + "match", + "emergence", "two", + "evolution", "crystal", + "database", + "weak", "arrangements", - "six", - "limited", - "match", - "design", - "sheets", "mechanism", - "followed", - "structures", - "protein", - "yield", - "weak", - "complex", - "searches", - "insertion", - "natural", - "sequence", - "fusion", - "beta", + "challenge", + "designs", + "containing", + "presumably", "computational", - "form", - "contributed", - "database", - "alternative", - "packing", - "scop", - "formed" + "connectivities", + "similar" ], "release_date":"2013-06-19", "publication":"\"Precise assembly of complex beta sheet topologies from de novo designed building blocks\", Elife, 4", @@ -87632,11 +87810,11 @@ }, { "sim":121.0, - "partner":"2n4e" + "partner":"2n41" }, { "sim":121.0, - "partner":"2n41" + "partner":"2n4e" }, { "sim":115.0, @@ -87664,11 +87842,11 @@ }, { "sim":74.0, - "partner":"2mbl" + "partner":"2mbm" }, { "sim":74.0, - "partner":"2mbm" + "partner":"2mbl" } ], "seq_thr_sim_natural":[ @@ -87784,11 +87962,11 @@ ], "subtitle":"Crystal structure of de novo designed serine hydrolase osh55.14_e3, northeast structural genomics consortium target or342", "tags":[ + "de novo protein", "northeast structural genomics consortium (nesg) target or342", + "psi-biology", "structural genomics", - "protein structure initiative", - "de novo protein", - "psi-biology" + "protein structure initiative" ], "keywords":[ "description", @@ -88024,14 +88202,14 @@ ], "subtitle":"Crystal structure of dehalogenase halotag2 with halts at the resolution 1.8a. northeast structural genomics consortium (nesg) target or150", "tags":[ - "halts", - "halogenase", + "nesg", + "de novo protein", "northeast structural genomics consortium", + "halogenase", + "halts", + "psi-biology", "structural genomics", - "protein structure initiative", - "de novo protein", - "nesg", - "psi-biology" + "protein structure initiative" ], "keywords":[ "description", @@ -88106,11 +88284,11 @@ }, { "sim":619.0, - "partner":"3fwh" + "partner":"3g9x" }, { "sim":619.0, - "partner":"3g9x" + "partner":"3fwh" }, { "sim":617.0, @@ -88178,11 +88356,11 @@ }, { "sim":256.0, - "partner":"1iz8" + "partner":"1k63" }, { "sim":256.0, - "partner":"1k63" + "partner":"1iz8" }, { "sim":256.0, @@ -88292,18 +88470,6 @@ "sim":108.0, "partner":"1bee" }, - { - "sim":107.0, - "partner":"2dhc" - }, - { - "sim":107.0, - "partner":"2dhd" - }, - { - "sim":107.0, - "partner":"2dhe" - }, { "sim":107.0, "partner":"2had" @@ -88322,11 +88488,11 @@ }, { "sim":107.0, - "partner":"1cij" + "partner":"2yxp" }, { "sim":107.0, - "partner":"2yxp" + "partner":"1cij" }, { "sim":107.0, @@ -88344,10 +88510,22 @@ "sim":107.0, "partner":"1ede" }, + { + "sim":107.0, + "partner":"2dhc" + }, { "sim":107.0, "partner":"1be0" }, + { + "sim":107.0, + "partner":"2dhd" + }, + { + "sim":107.0, + "partner":"2dhe" + }, { "sim":105.0, "partner":"1hde" @@ -88546,23 +88724,23 @@ }, { "sim":59.0, - "partner":"3kd2" + "partner":"3pi6" }, { "sim":59.0, - "partner":"4b9e" + "partner":"4b9a" }, { "sim":59.0, - "partner":"3pi6" + "partner":"3kda" }, { "sim":59.0, - "partner":"4b9a" + "partner":"3kd2" }, { "sim":59.0, - "partner":"3kda" + "partner":"4b9e" }, { "sim":59.0, @@ -88590,11 +88768,11 @@ }, { "sim":55.0, - "partner":"3t4u" + "partner":"3t52" }, { "sim":55.0, - "partner":"3t52" + "partner":"3t4u" }, { "sim":55.0, @@ -88610,15 +88788,15 @@ }, { "sim":52.0, - "partner":"4itv" + "partner":"4ivj" }, { "sim":52.0, - "partner":"4ivj" + "partner":"4iq4" }, { "sim":52.0, - "partner":"4iq4" + "partner":"4itv" }, { "sim":51.0, @@ -88770,77 +88948,77 @@ ], "subtitle":"Three-dimensional structure of triclinic form of de novo design insertion domain, northeast structural genomics consortium (nesg) target or327", "tags":[ - "northeast structural genomics consortium", - "structural genomics", - "protein structure initiative", - "de novo protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", + "domain insertion", "psi-biology", - "domain insertion" + "structural genomics", + "protein structure initiative" ], "keywords":[ - "interfaces", - "containing", - "domain", - "demonstrate", - "evolution", - "poses", - "designs", + "designed", + "form", + "complex", + "alternative", + "models", + "limited", + "design", + "beta", "one", - "matches", + "interfaces", "another", - "amino", - "models", - "large", - "newly", + "number", + "formed", + "fusion", + "poses", "merged", - "presumably", - "similar", - "extended", + "structures", "de", - "novo", "single", - "challenge", + "natural", + "domain", + "different", + "newly", + "extended", + "acid", "sheet", - "connectivities", + "matches", + "insertion", + "closely", + "protein", + "followed", "topologies", - "acid", + "six", + "amino", "optimization", - "designed", - "number", - "emergence", + "yield", + "large", + "packing", + "searches", + "sheets", + "contributed", "may", - "different", - "closely", + "novo", + "scop", + "demonstrate", + "sequence", + "match", + "emergence", "two", + "evolution", "crystal", + "database", + "weak", "arrangements", - "six", - "limited", - "match", - "design", - "sheets", "mechanism", - "followed", - "structures", - "protein", - "yield", - "weak", - "complex", - "searches", - "insertion", - "natural", - "sequence", - "fusion", - "beta", + "challenge", + "designs", + "containing", + "presumably", "computational", - "form", - "contributed", - "database", - "alternative", - "packing", - "scop", - "formed" + "connectivities", + "similar" ], "release_date":"2013-07-24", "publication":"\"Precise assembly of complex beta sheet topologies from de novo designed building blocks\", Elife, 4", @@ -88893,11 +89071,11 @@ }, { "sim":121.0, - "partner":"2n4e" + "partner":"2n41" }, { "sim":121.0, - "partner":"2n41" + "partner":"2n4e" }, { "sim":115.0, @@ -88925,11 +89103,11 @@ }, { "sim":74.0, - "partner":"2mbl" + "partner":"2mbm" }, { "sim":74.0, - "partner":"2mbm" + "partner":"2mbl" } ], "seq_thr_sim_natural":[ @@ -89101,79 +89279,79 @@ "three-helix bundle" ], "keywords":[ - "neutralization", - "hence", - "prevent", + "induce", + "encourage", + "variable", "largely", - "elderly", - "cases", + "disease", + "thermally", + "design", "strategies", - "induce", + "development", + "targeted", + "evaluation", + "show", + "methods", + "influenza", + "immunodeficiency", + "traditional", + "research", + "represent", + "hence", + "vaccines", + "prevent", + "epitopes", + "conformationally", + "identified", + "respiratory", + "structure", + "mimic", + "scaffolds", + "leads", "results", - "syncytial", + "provide", + "although", + "new", "virus", - "viral", + "targets", + "protective", "vulnerable", - "protect", - "respiratory", - "neutralizing", - "inducing", - "generate", - "accurately", - "potent", - "stable", - "although", - "principle", - "scaffolds", - "human", - "including", + "protein", + "cases", + "syncytial", "pathogens", - "encourage", - "young", - "antigenically", - "influenza", - "small", - "highly", - "needed", - "targeted", - "provide", - "variable", - "resisted", - "identified", - "methods", - "evaluation", "generally", "infectious", - "several", - "show", - "design", "infants", + "young", + "several", + "viral", "children", - "mimic", - "protein", - "targets", - "variety", - "development", - "represent", - "structure", "promising", - "thermally", - "conformationally", - "epitopes", + "including", + "highly", + "neutralization", + "small", + "neutralizing", + "proof", + "accurately", + "major", + "principle", + "elderly", + "variety", + "potent", + "protect", + "stable", "vaccine", + "human", + "inducing", + "resisted", "computational", - "vaccines", - "research", - "leads", "epitope", - "proof", - "major", + "antigenically", + "generate", "antibodies", - "immunodeficiency", - "disease", - "protective", - "traditional", - "new" + "needed" ], "release_date":"2014-02-12", "publication":"\"Proof of principle for epitope-focused vaccine design\", Nature, 507, 201-206", @@ -89338,13 +89516,13 @@ ], "subtitle":"Crystal structure of engineered protein, northeast structural genomics consortium target or422", "tags":[ - "northeast structural genomics consortium", - "structural genomics", - "protein structure initiative", - "de novo protein", + "engineered protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", "psi-biology", - "engineered protein" + "structural genomics", + "protein structure initiative" ], "keywords":[ "description", @@ -89447,11 +89625,11 @@ }, { "sim":434.0, - "partner":"1a53" + "partner":"1lbl" }, { "sim":434.0, - "partner":"1lbl" + "partner":"1a53" }, { "sim":434.0, @@ -89644,13 +89822,13 @@ ], "subtitle":"X-ray structure of the de-novo design amidase at the resolution 1.8a, northeast structural genomics consortium (nesg) target or398", "tags":[ - "amidase", - "structural genomics", - "protein structure initiative", + "de novo design", "de novo protein", + "amidase", "psi-biology", + "structural genomics", "northeast structural genomics consortium (nesg)", - "de novo design" + "protein structure initiative" ], "keywords":[ "description", @@ -89818,98 +89996,98 @@ ], "subtitle":"Crystal structure of monomeric tencon variant p54cr4-31", "tags":[ + "de novo protein", "fibronectin type iii fold", - "alternate scaffold", - "de novo protein" + "alternate scaffold" ], "keywords":[ - "biophysical", - "domain", - "analysis", - "cases", - "aggregation", - "link", - "perfect", - "five", - "crystal", - "support", - "determined", - "hinge", - "hexameric", - "sequences", - "order", - "basis", - "regions", - "position", - "5", - "77", - "produce", - "variants", - "less", - "number", - "resulting", - "suggests", - "particularly", - "odd", + "dimers", + "engineering", "whose", - "structures", + "0", + "structural", + "number", + "well", + "longest", + "residue", + "degrees", + "various", + "six", + "5", "positions", - "solution", - "involves", - "exhibit", - "form", - "swapped", - "properties", - "sec", + "helical", + "dimerization", "promoting", - "higher", - "blocked", - "oligomerization", - "tencon", - "4", - "may", + "domains", "inserted", - "according", - "iii", + "proline", + "swapped", + "crystal", + "stable", + "correlating", + "differ", "78", - "engineering", - "six", - "observed", - "type", - "helical", + "efforts", + "particularly", + "aggregation", "fg", + "residues", + "tencon", + "basis", + "showing", + "blocked", + "may", + "iii", + "contain", + "swapping", + "higher", + "regions", + "hexameric", "surface", - "proline", - "sequence", + "exhibit", + "destabilize", + "suggests", + "produce", + "different", + "domain", + "oligomeric", + "properties", + "oligomerization", + "type", + "solution", "formation", - "structural", - "dimerization", - "3d", - "differ", - "showing", - "stable", + "sequence", + "hinge", "insertions", - "efforts", - "fibronectin", + "3d", + "77", "desired", - "well", - "different", - "residues", + "odd", "reveal", - "dimers", - "domains", - "residue", - "0", - "degrees", - "various", - "understanding", - "oligomeric", - "destabilize", - "longest", - "swapping", + "form", + "analysis", + "order", + "involves", + "sequences", "loop", - "contain", - "correlating" + "variants", + "observed", + "structures", + "link", + "perfect", + "determined", + "resulting", + "according", + "sec", + "fibronectin", + "biophysical", + "understanding", + "cases", + "4", + "support", + "position", + "less", + "five" ], "release_date":"2014-01-29", "publication":"\"C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold\", Proteins, 82, 1359-1369", @@ -90157,98 +90335,98 @@ ], "subtitle":"Crystal structure of tencon variant p40ar2-32r2", "tags":[ + "de novo protein", "fibronectin type iii fold", - "alternate scaffold", - "de novo protein" + "alternate scaffold" ], "keywords":[ - "biophysical", - "domain", - "analysis", - "cases", - "aggregation", - "link", - "perfect", - "five", - "crystal", - "support", - "determined", - "hinge", - "hexameric", - "sequences", - "order", - "basis", - "regions", - "position", - "5", - "77", - "produce", - "variants", - "less", - "number", - "resulting", - "suggests", - "particularly", - "odd", + "dimers", + "engineering", "whose", - "structures", + "0", + "structural", + "number", + "well", + "longest", + "residue", + "degrees", + "various", + "six", + "5", "positions", - "solution", - "involves", - "exhibit", - "form", - "swapped", - "properties", - "sec", + "helical", + "dimerization", "promoting", - "higher", - "blocked", - "oligomerization", - "tencon", - "4", - "may", + "domains", "inserted", - "according", - "iii", + "proline", + "swapped", + "crystal", + "stable", + "correlating", + "differ", "78", - "engineering", - "six", - "observed", - "type", - "helical", + "efforts", + "particularly", + "aggregation", "fg", + "residues", + "tencon", + "basis", + "showing", + "blocked", + "may", + "iii", + "contain", + "swapping", + "higher", + "regions", + "hexameric", "surface", - "proline", - "sequence", + "exhibit", + "destabilize", + "suggests", + "produce", + "different", + "domain", + "oligomeric", + "properties", + "oligomerization", + "type", + "solution", "formation", - "structural", - "dimerization", - "3d", - "differ", - "showing", - "stable", + "sequence", + "hinge", "insertions", - "efforts", - "fibronectin", + "3d", + "77", "desired", - "well", - "different", - "residues", + "odd", "reveal", - "dimers", - "domains", - "residue", - "0", - "degrees", - "various", - "understanding", - "oligomeric", - "destabilize", - "longest", - "swapping", + "form", + "analysis", + "order", + "involves", + "sequences", "loop", - "contain", - "correlating" + "variants", + "observed", + "structures", + "link", + "perfect", + "determined", + "resulting", + "according", + "sec", + "fibronectin", + "biophysical", + "understanding", + "cases", + "4", + "support", + "position", + "less", + "five" ], "release_date":"2014-01-29", "publication":"\"C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold\", Proteins, 82, 1359-1369", @@ -90520,98 +90698,98 @@ ], "subtitle":"Crystal structure of tencon variant p41br3-42", "tags":[ + "de novo protein", "fibronectin type iii fold", - "alternate scaffold", - "de novo protein" + "alternate scaffold" ], "keywords":[ - "biophysical", - "domain", - "analysis", - "cases", - "aggregation", - "link", - "perfect", - "five", - "crystal", - "support", - "determined", - "hinge", - "hexameric", - "sequences", - "order", - "basis", - "regions", - "position", - "5", - "77", - "produce", - "variants", - "less", - "number", - "resulting", - "suggests", - "particularly", - "odd", + "dimers", + "engineering", "whose", - "structures", + "0", + "structural", + "number", + "well", + "longest", + "residue", + "degrees", + "various", + "six", + "5", "positions", - "solution", - "involves", - "exhibit", - "form", - "swapped", - "properties", - "sec", + "helical", + "dimerization", "promoting", - "higher", - "blocked", - "oligomerization", - "tencon", - "4", - "may", + "domains", "inserted", - "according", - "iii", + "proline", + "swapped", + "crystal", + "stable", + "correlating", + "differ", "78", - "engineering", - "six", - "observed", - "type", - "helical", + "efforts", + "particularly", + "aggregation", "fg", + "residues", + "tencon", + "basis", + "showing", + "blocked", + "may", + "iii", + "contain", + "swapping", + "higher", + "regions", + "hexameric", "surface", - "proline", - "sequence", + "exhibit", + "destabilize", + "suggests", + "produce", + "different", + "domain", + "oligomeric", + "properties", + "oligomerization", + "type", + "solution", "formation", - "structural", - "dimerization", - "3d", - "differ", - "showing", - "stable", + "sequence", + "hinge", "insertions", - "efforts", - "fibronectin", + "3d", + "77", "desired", - "well", - "different", - "residues", + "odd", "reveal", - "dimers", - "domains", - "residue", - "0", - "degrees", - "various", - "understanding", - "oligomeric", - "destabilize", - "longest", - "swapping", + "form", + "analysis", + "order", + "involves", + "sequences", "loop", - "contain", - "correlating" + "variants", + "observed", + "structures", + "link", + "perfect", + "determined", + "resulting", + "according", + "sec", + "fibronectin", + "biophysical", + "understanding", + "cases", + "4", + "support", + "position", + "less", + "five" ], "release_date":"2014-01-29", "publication":"\"C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold\", Proteins, 82, 1359-1369", @@ -90863,98 +91041,98 @@ ], "subtitle":"Crystal structure of tencon variant a6", "tags":[ + "de novo protein", "fibronectin type iii fold", - "alternate scaffold", - "de novo protein" + "alternate scaffold" ], "keywords":[ - "biophysical", - "domain", - "analysis", - "cases", - "aggregation", - "link", - "perfect", - "five", - "crystal", - "support", - "determined", - "hinge", - "hexameric", - "sequences", - "order", - "basis", - "regions", - "position", - "5", - "77", - "produce", - "variants", - "less", - "number", - "resulting", - "suggests", - "particularly", - "odd", + "dimers", + "engineering", "whose", - "structures", + "0", + "structural", + "number", + "well", + "longest", + "residue", + "degrees", + "various", + "six", + "5", "positions", - "solution", - "involves", - "exhibit", - "form", - "swapped", - "properties", - "sec", + "helical", + "dimerization", "promoting", - "higher", - "blocked", - "oligomerization", - "tencon", - "4", - "may", + "domains", "inserted", - "according", - "iii", + "proline", + "swapped", + "crystal", + "stable", + "correlating", + "differ", "78", - "engineering", - "six", - "observed", - "type", - "helical", + "efforts", + "particularly", + "aggregation", "fg", + "residues", + "tencon", + "basis", + "showing", + "blocked", + "may", + "iii", + "contain", + "swapping", + "higher", + "regions", + "hexameric", "surface", - "proline", - "sequence", + "exhibit", + "destabilize", + "suggests", + "produce", + "different", + "domain", + "oligomeric", + "properties", + "oligomerization", + "type", + "solution", "formation", - "structural", - "dimerization", - "3d", - "differ", - "showing", - "stable", + "sequence", + "hinge", "insertions", - "efforts", - "fibronectin", + "3d", + "77", "desired", - "well", - "different", - "residues", + "odd", "reveal", - "dimers", - "domains", - "residue", - "0", - "degrees", - "various", - "understanding", - "oligomeric", - "destabilize", - "longest", - "swapping", + "form", + "analysis", + "order", + "involves", + "sequences", "loop", - "contain", - "correlating" + "variants", + "observed", + "structures", + "link", + "perfect", + "determined", + "resulting", + "according", + "sec", + "fibronectin", + "biophysical", + "understanding", + "cases", + "4", + "support", + "position", + "less", + "five" ], "release_date":"2014-01-29", "publication":"\"C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold\", Proteins, 82, 1359-1369", @@ -91225,98 +91403,98 @@ ], "subtitle":"Crystal structure of tencon variant d4", "tags":[ + "de novo protein", "fibronectin type iii fold", - "alternate scaffold", - "de novo protein" + "alternate scaffold" ], "keywords":[ - "biophysical", - "domain", - "analysis", - "cases", - "aggregation", - "link", - "perfect", - "five", - "crystal", - "support", - "determined", - "hinge", - "hexameric", - "sequences", - "order", - "basis", - "regions", - "position", - "5", - "77", - "produce", - "variants", - "less", - "number", - "resulting", - "suggests", - "particularly", - "odd", + "dimers", + "engineering", "whose", - "structures", + "0", + "structural", + "number", + "well", + "longest", + "residue", + "degrees", + "various", + "six", + "5", "positions", - "solution", - "involves", - "exhibit", - "form", - "swapped", - "properties", - "sec", + "helical", + "dimerization", "promoting", - "higher", - "blocked", - "oligomerization", - "tencon", - "4", - "may", + "domains", "inserted", - "according", - "iii", + "proline", + "swapped", + "crystal", + "stable", + "correlating", + "differ", "78", - "engineering", - "six", - "observed", - "type", - "helical", + "efforts", + "particularly", + "aggregation", "fg", + "residues", + "tencon", + "basis", + "showing", + "blocked", + "may", + "iii", + "contain", + "swapping", + "higher", + "regions", + "hexameric", "surface", - "proline", - "sequence", + "exhibit", + "destabilize", + "suggests", + "produce", + "different", + "domain", + "oligomeric", + "properties", + "oligomerization", + "type", + "solution", "formation", - "structural", - "dimerization", - "3d", - "differ", - "showing", - "stable", + "sequence", + "hinge", "insertions", - "efforts", - "fibronectin", + "3d", + "77", "desired", - "well", - "different", - "residues", + "odd", "reveal", - "dimers", - "domains", - "residue", - "0", - "degrees", - "various", - "understanding", - "oligomeric", - "destabilize", - "longest", - "swapping", + "form", + "analysis", + "order", + "involves", + "sequences", "loop", - "contain", - "correlating" + "variants", + "observed", + "structures", + "link", + "perfect", + "determined", + "resulting", + "according", + "sec", + "fibronectin", + "biophysical", + "understanding", + "cases", + "4", + "support", + "position", + "less", + "five" ], "release_date":"2014-01-29", "publication":"\"C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold\", Proteins, 82, 1359-1369", @@ -91564,98 +91742,98 @@ ], "subtitle":"Crystal structure of tencon variant g10", "tags":[ + "de novo protein", "fibronectin type iii fold", - "alternate scaffold", - "de novo protein" + "alternate scaffold" ], "keywords":[ - "biophysical", - "domain", - "analysis", - "cases", - "aggregation", - "link", - "perfect", - "five", - "crystal", - "support", - "determined", - "hinge", - "hexameric", - "sequences", - "order", - "basis", - "regions", - "position", - "5", - "77", - "produce", - "variants", - "less", - "number", - "resulting", - "suggests", - "particularly", - "odd", + "dimers", + "engineering", "whose", - "structures", + "0", + "structural", + "number", + "well", + "longest", + "residue", + "degrees", + "various", + "six", + "5", "positions", - "solution", - "involves", - "exhibit", - "form", - "swapped", - "properties", - "sec", + "helical", + "dimerization", "promoting", - "higher", - "blocked", - "oligomerization", - "tencon", - "4", - "may", + "domains", "inserted", - "according", - "iii", + "proline", + "swapped", + "crystal", + "stable", + "correlating", + "differ", "78", - "engineering", - "six", - "observed", - "type", - "helical", + "efforts", + "particularly", + "aggregation", "fg", + "residues", + "tencon", + "basis", + "showing", + "blocked", + "may", + "iii", + "contain", + "swapping", + "higher", + "regions", + "hexameric", "surface", - "proline", - "sequence", + "exhibit", + "destabilize", + "suggests", + "produce", + "different", + "domain", + "oligomeric", + "properties", + "oligomerization", + "type", + "solution", "formation", - "structural", - "dimerization", - "3d", - "differ", - "showing", - "stable", + "sequence", + "hinge", "insertions", - "efforts", - "fibronectin", + "3d", + "77", "desired", - "well", - "different", - "residues", + "odd", "reveal", - "dimers", - "domains", - "residue", - "0", - "degrees", - "various", - "understanding", - "oligomeric", - "destabilize", - "longest", - "swapping", + "form", + "analysis", + "order", + "involves", + "sequences", "loop", - "contain", - "correlating" + "variants", + "observed", + "structures", + "link", + "perfect", + "determined", + "resulting", + "according", + "sec", + "fibronectin", + "biophysical", + "understanding", + "cases", + "4", + "support", + "position", + "less", + "five" ], "release_date":"2014-01-29", "publication":"\"C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold\", Proteins, 82, 1359-1369", @@ -91928,13 +92106,13 @@ ], "subtitle":"Crystal structure of engineered protein, northeast structural genomics consortium target or404", "tags":[ - "northeast structural genomics consortium", - "structural genomics", - "protein structure initiative", - "de novo protein", + "engineered protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", "psi-biology", - "engineered protein" + "structural genomics", + "protein structure initiative" ], "keywords":[ "description", @@ -92037,11 +92215,11 @@ }, { "sim":409.0, - "partner":"1a53" + "partner":"1lbl" }, { "sim":409.0, - "partner":"1lbl" + "partner":"1a53" }, { "sim":409.0, @@ -92210,53 +92388,53 @@ ], "subtitle":"N-terminal beta-strand swapping in a consensus derived alternative scaffold driven by stabilizing hydrophobic interactions", "tags":[ - "tencon", "b-strand swapping", "de novo protein", "fn3-like domain", - "alternative scaffold" + "alternative scaffold", + "tencon" ], "keywords":[ - "domain", - "fn3", - "tenascin", + "unswapped", + "surface", + "alternative", + "driving", + "hydrophobic", + "differently", "chain", - "results", - "tighter", - "reveals", + "fn3", "patch", - "thus", - "also", - "stable", - "appears", - "burial", "dimer", - "orients", + "core", + "side", + "domain", + "tenascin", + "thus", + "structure", "packs", - "provide", - "leading", - "crystal", "determined", - "scaffold", - "comparison", - "differently", - "core", + "results", "residue", - "driving", - "hydrophobic", + "also", + "provide", + "hydrophobicity", "f88", - "unswapped", - "surface", - "structure", + "burial", "tightly", - "formation", - "side", - "alternative", "packing", - "hydrophobicity", - "swapping", + "leading", + "formation", "forces", - "compact" + "appears", + "scaffold", + "reveals", + "swapping", + "crystal", + "stable", + "compact", + "tighter", + "orients", + "comparison" ], "release_date":"2014-02-26", "publication":"\"N-terminal beta-strand swapping in a consensus-derived alternative scaffold driven by stabilizing hydrophobic interactions\", Proteins, 82, 1527-1533", @@ -92540,110 +92718,110 @@ ], "subtitle":"Adhiron: a stable and versatile peptide display scaffold - full length adhiron", "tags":[ - "protein scaffold", "de novo protein", - "consensus protein" + "consensus protein", + "protein scaffold" ], "keywords":[ - "thermal", - "domain", - "modifier", - "sh2", - "specificity", - "use", - "low", - "date", - "peptide", - "expressed", - "including", - "allowing", - "designed", - "homologous", - "variable", - "crystal", - "determined", - "target", - "based", - "sequences", - "regions", - "structure", "escherichia", - "clones", - "novel", - "molecule", + "yeast", + "molecular", + "essentially", "platelet", - "growth", - "cell", - "\u00e5", - "small", - "phytocystatin", - "highly", - "binders", - "endothelial", "recognition", + "resolution", + "characterised", + "tm", + "well", + "sumo", + "reagents", + "protein", + "binding", + "comprising", + "fibroblast", "motif", - "often", - "nanomolar", - "complexity", - "ca", - "shows", - "molecules", - "consensus", - "stability", - "quality", + "demonstrate", + "modifier", + "two", + "applications", + "crystal", + "region", + "stable", + "10", "100", - "molecular", - "fgf1", - "coli", + "growth", + "screened", + "shows", + "specificity", "adhirons", + "clones", + "adhesion", + "selected", + "identified", + "sh2", + "specific", + "library", + "termed", + "thermal", "contained", - "essentially", - "resolution", + "stability", + "endothelial", + "constructed", + "low", + "use", + "consensus", + "factor", + "scaffold", + "highly", + "small", + "compact", "four", - "grb2", - "reagents", - "1", - "10", - "adhiron", + "nanomolar", + "allowing", + "regions", "interactive", - "region", - "screened", - "specific", - "fibroblast", - "applications", - "insertion", + "including", + "1", + "peptide", + "variable", + "ca", + "molecule", "displayed", - "high", + "binders", + "domain", + "fold", + "revealing", + "insertion", + "complexity", + "cell", + "phytocystatin", + "coli", "sequence", - "sumo", - "known", + "adhiron", + "designed", + "often", + "homologous", + "sequences", "cd31", - "selected", - "compact", - "library", - "factor", - "demonstrate", - "revealing", - "termed", - "stable", "efficacy", - "fold", - "human", - "constructed", - "well", - "affinities", - "two", - "identified", - "adhesion", + "expressed", + "based", + "\u00e5", + "structure", "isoforms", - "scaffold", + "determined", + "target", + "known", + "grb2", "examples", - "protein", - "characterised", - "comprising", - "tm", - "yeast", - "binding" + "molecules", + "high", + "date", + "quality", + "human", + "affinities", + "fgf1", + "novel" ], "release_date":"2014-04-09", "publication":"\"Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications\", Protein Eng.Des.Sel., 27, 145-155", @@ -92680,11 +92858,11 @@ }, { "sim":134.0, - "partner":"7zqa" + "partner":"7zq8" }, { "sim":134.0, - "partner":"7zq8" + "partner":"7zqa" }, { "sim":128.0, @@ -92706,11 +92884,11 @@ }, { "sim":112.0, - "partner":"3ul6" + "partner":"3ul5" }, { "sim":112.0, - "partner":"3ul5" + "partner":"3ul6" }, { "sim":108.0, @@ -92822,110 +93000,110 @@ ], "subtitle":"Adhiron: a stable and versatile peptide display scaffold - truncated adhiron", "tags":[ - "protein scaffold", "de novo protein", - "consensus protein" + "consensus protein", + "protein scaffold" ], "keywords":[ - "thermal", - "domain", - "modifier", - "sh2", - "specificity", - "use", - "low", - "date", - "peptide", - "expressed", - "including", - "allowing", - "designed", - "homologous", - "variable", - "crystal", - "determined", - "target", - "based", - "sequences", - "regions", - "structure", "escherichia", - "clones", - "novel", - "molecule", + "yeast", + "molecular", + "essentially", "platelet", - "growth", - "cell", - "\u00e5", - "small", - "phytocystatin", - "highly", - "binders", - "endothelial", "recognition", + "resolution", + "characterised", + "tm", + "well", + "sumo", + "reagents", + "protein", + "binding", + "comprising", + "fibroblast", "motif", - "often", - "nanomolar", - "complexity", - "ca", - "shows", - "molecules", - "consensus", - "stability", - "quality", + "demonstrate", + "modifier", + "two", + "applications", + "crystal", + "region", + "stable", + "10", "100", - "molecular", - "fgf1", - "coli", + "growth", + "screened", + "shows", + "specificity", "adhirons", + "clones", + "adhesion", + "selected", + "identified", + "sh2", + "specific", + "library", + "termed", + "thermal", "contained", - "essentially", - "resolution", + "stability", + "endothelial", + "constructed", + "low", + "use", + "consensus", + "factor", + "scaffold", + "highly", + "small", + "compact", "four", - "grb2", - "reagents", - "1", - "10", - "adhiron", + "nanomolar", + "allowing", + "regions", "interactive", - "region", - "screened", - "specific", - "fibroblast", - "applications", - "insertion", + "including", + "1", + "peptide", + "variable", + "ca", + "molecule", "displayed", - "high", + "binders", + "domain", + "fold", + "revealing", + "insertion", + "complexity", + "cell", + "phytocystatin", + "coli", "sequence", - "sumo", - "known", + "adhiron", + "designed", + "often", + "homologous", + "sequences", "cd31", - "selected", - "compact", - "library", - "factor", - "demonstrate", - "revealing", - "termed", - "stable", "efficacy", - "fold", - "human", - "constructed", - "well", - "affinities", - "two", - "identified", - "adhesion", + "expressed", + "based", + "\u00e5", + "structure", "isoforms", - "scaffold", + "determined", + "target", + "known", + "grb2", "examples", - "protein", - "characterised", - "comprising", - "tm", - "yeast", - "binding" + "molecules", + "high", + "date", + "quality", + "human", + "affinities", + "fgf1", + "novel" ], "release_date":"2014-04-09", "publication":"\"Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications\", Protein Eng.Des.Sel., 27, 145-155", @@ -92962,11 +93140,11 @@ }, { "sim":134.0, - "partner":"7zqa" + "partner":"7zq8" }, { "sim":134.0, - "partner":"7zq8" + "partner":"7zqa" }, { "sim":128.0, @@ -92988,11 +93166,11 @@ }, { "sim":112.0, - "partner":"3ul6" + "partner":"3ul5" }, { "sim":112.0, - "partner":"3ul5" + "partner":"3ul6" }, { "sim":108.0, @@ -93185,85 +93363,85 @@ ], "subtitle":"Crystal structure of a computationally designed rsv-presenting epitope scaffold and its elicited antibody 17hd9", "tags":[ + "epitope scaffold", "immune system", - "hairpin", "antibody", - "epitope scaffold" + "hairpin" ], "keywords":[ - "neutralization", - "hence", - "prevent", + "induce", + "encourage", + "variable", "largely", - "elderly", - "cases", + "disease", + "thermally", + "design", "strategies", - "induce", + "development", + "targeted", + "evaluation", + "show", + "methods", + "influenza", + "immunodeficiency", + "traditional", + "research", + "represent", + "hence", + "vaccines", + "prevent", + "epitopes", + "conformationally", + "identified", + "respiratory", + "structure", + "mimic", + "scaffolds", + "leads", "results", - "syncytial", + "provide", + "although", + "new", "virus", - "viral", + "targets", + "protective", "vulnerable", - "protect", - "respiratory", - "neutralizing", - "inducing", - "generate", - "accurately", - "potent", - "stable", - "although", - "principle", - "scaffolds", - "human", - "including", + "protein", + "cases", + "syncytial", "pathogens", - "encourage", - "young", - "antigenically", - "influenza", - "small", - "highly", - "needed", - "targeted", - "provide", - "variable", - "resisted", - "identified", - "methods", - "evaluation", "generally", "infectious", - "several", - "show", - "design", "infants", + "young", + "several", + "viral", "children", - "mimic", - "protein", - "targets", - "variety", - "development", - "represent", - "structure", "promising", - "thermally", - "conformationally", - "epitopes", + "including", + "highly", + "neutralization", + "small", + "neutralizing", + "proof", + "accurately", + "major", + "principle", + "elderly", + "variety", + "potent", + "protect", + "stable", "vaccine", + "human", + "inducing", + "resisted", "computational", - "vaccines", - "research", - "leads", "epitope", - "proof", - "major", + "antigenically", + "generate", "antibodies", - "immunodeficiency", - "disease", - "protective", - "traditional", - "new" + "needed" ], "release_date":"2014-02-12", "publication":"\"Proof of principle for epitope-focused vaccine design\", Nature, 507, 201-206", @@ -93384,113 +93562,113 @@ "subtitle":"Crystal structure of a computational designed engrailed homeodomain variant fused with yfp", "tags":[ "de novo protein", + "helix-turn-helix", "fluorescent protein", - "fluorescent protein, de novo protein", - "helix-turn-helix" + "fluorescent protein, de novo protein" ], "keywords":[ - "domain", - "differing", - "characteristics", - "monomeric", - "change", - "available", - "crystallography", - "designed", - "generated", - "mutations", - "provide", - "flexibility", - "potential", - "target", - "hinge", - "instead", - "sequences", - "altered", - "suggested", - "adopt", - "structure", - "implementations", - "computationally", - "predict", - "simulation", - "models", - "proteins", - "hypothesized", - "similar", "whether", - "point", - "typically", + "dimers", + "molecular", + "especially", + "adopt", + "structural", + "protein", + "increased", + "given", + "differing", "attempting", - "used", - "often", - "md", - "dynamics", - "derived", "showed", - "appropriate", - "exhibit", - "mutants", - "recover", + "confirmed", + "two", + "region", + "stable", + "similar", + "simulations", + "flexibility", + "typically", + "conformational", + "homeodomain", + "enh", "nearly", - "primarily", - "molecular", - "large", - "screening", - "increased", - "identify", - "method", - "would", - "engineer", - "successful", "dimer", - "region", + "computationally", + "relative", "protocol", - "simulations", - "design", - "standard", - "states", - "required", - "competing", - "sequence", - "could", + "primarily", "input", - "structural", - "sample", - "one", - "tested", - "conformational", + "derived", "approach", - "stable", - "contrast", - "fold", - "different", - "confirmed", - "especially", - "fragment", - "two", - "subsequently", - "counterpart", - "leading", - "dimers", - "state", - "considered", - "enh", - "protein", - "given", - "identical", - "backbone", + "large", + "proteins", + "mutants", + "predict", + "available", "homodimer", + "swapping", "computational", - "compelling", - "engrailed", - "homeodomain", + "required", + "standard", + "exhibit", + "design", "accommodate", + "used", + "instead", "possible", - "relative", - "swapping", + "altered", + "different", + "domain", + "potential", + "tested", + "fold", + "considered", + "tool", + "appropriate", + "successful", + "point", + "engrailed", + "leading", + "backbone", + "contrast", + "states", + "sequence", + "hinge", + "suggested", + "identical", + "compelling", + "screening", + "method", + "engineer", + "characteristics", + "could", + "dynamics", + "designed", + "models", + "often", + "implementations", + "counterpart", + "sequences", + "one", + "mutations", "loop", - "tool" + "competing", + "structure", + "monomeric", + "provide", + "subsequently", + "fragment", + "target", + "recover", + "crystallography", + "state", + "would", + "identify", + "change", + "md", + "generated", + "sample", + "simulation", + "hypothesized" ], "release_date":"2014-11-05", "publication":"\"Using Molecular Dynamics Simulations as an Aid in the Prediction of Domain Swapping of Computationally Designed Protein Variants\", J.Mol.Biol., 427, 2697-2706", @@ -93589,113 +93767,113 @@ "subtitle":"Crystal structure of a computational designed engrailed homeodomain variant fused with yfp", "tags":[ "de novo protein", + "helix-turn-helix", "fluorescent protein", - "fluorescent protein, de novo protein", - "helix-turn-helix" + "fluorescent protein, de novo protein" ], "keywords":[ - "domain", - "differing", - "characteristics", - "monomeric", - "change", - "available", - "crystallography", - "designed", - "generated", - "mutations", - "provide", - "flexibility", - "potential", - "target", - "hinge", - "instead", - "sequences", - "altered", - "suggested", - "adopt", - "structure", - "implementations", - "computationally", - "predict", - "simulation", - "models", - "proteins", - "hypothesized", - "similar", "whether", - "point", - "typically", + "dimers", + "molecular", + "especially", + "adopt", + "structural", + "protein", + "increased", + "given", + "differing", "attempting", - "used", - "often", - "md", - "dynamics", - "derived", "showed", - "appropriate", - "exhibit", - "mutants", - "recover", + "confirmed", + "two", + "region", + "stable", + "similar", + "simulations", + "flexibility", + "typically", + "conformational", + "homeodomain", + "enh", "nearly", - "primarily", - "molecular", - "large", - "screening", - "increased", - "identify", - "method", - "would", - "engineer", - "successful", "dimer", - "region", + "computationally", + "relative", "protocol", - "simulations", - "design", - "standard", - "states", - "required", - "competing", - "sequence", - "could", + "primarily", "input", - "structural", - "sample", - "one", - "tested", - "conformational", + "derived", "approach", - "stable", - "contrast", - "fold", - "different", - "confirmed", - "especially", - "fragment", - "two", - "subsequently", - "counterpart", - "leading", - "dimers", - "state", - "considered", - "enh", - "protein", - "given", - "identical", - "backbone", + "large", + "proteins", + "mutants", + "predict", + "available", "homodimer", + "swapping", "computational", - "compelling", - "engrailed", - "homeodomain", + "required", + "standard", + "exhibit", + "design", "accommodate", + "used", + "instead", "possible", - "relative", - "swapping", + "altered", + "different", + "domain", + "potential", + "tested", + "fold", + "considered", + "tool", + "appropriate", + "successful", + "point", + "engrailed", + "leading", + "backbone", + "contrast", + "states", + "sequence", + "hinge", + "suggested", + "identical", + "compelling", + "screening", + "method", + "engineer", + "characteristics", + "could", + "dynamics", + "designed", + "models", + "often", + "implementations", + "counterpart", + "sequences", + "one", + "mutations", "loop", - "tool" + "competing", + "structure", + "monomeric", + "provide", + "subsequently", + "fragment", + "target", + "recover", + "crystallography", + "state", + "would", + "identify", + "change", + "md", + "generated", + "sample", + "simulation", + "hypothesized" ], "release_date":"2014-11-05", "publication":"\"Using Molecular Dynamics Simulations as an Aid in the Prediction of Domain Swapping of Computationally Designed Protein Variants\", J.Mol.Biol., 427, 2697-2706", @@ -93801,88 +93979,88 @@ "helix-turn-helix" ], "keywords":[ - "unknown", - "oligomers", - "independent", - "monomeric", - "studies", - "drosophila", - "thermostability", + "especially", + "experimental", "complexes", - "elucidating", - "low", - "mutations", - "parallel", - "modeling", - "generally", - "features", - "based", - "order", - "thermostabilizing", - "interactions", - "structure", - "novel", - "interfaces", + "exhibits", + "model", + "protein", + "facilitated", + "accurate", + "helical", + "stabilization", + "novo", + "unknown", "similar", - "de", - "serve", - "nature", + "previous", "introduction", - "atomic", - "solution", - "assembly", - "function", - "likely", "shows", - "compared", - "achieved", - "demonstrated", - "exhibits", - "higher", - "common", - "resulted", - "report", - "accurate", - "method", - "dimer", - "type", + "mechanisms", + "homeodomain", "action", - "design", - "characterization", - "model", - "helical", - "facilitated", - "nmr", - "symmetry", + "dimer", "biological", - "formation", - "c2", + "level", + "approach", "packing", - "stabilization", + "achieved", + "generally", + "low", "accuracy", - "poor", + "characterization", + "success", + "scaffold", + "homodimer", + "higher", + "features", + "c2", + "symmetry", "critical", + "design", + "compared", + "atomic", + "assembly", + "drosophila", + "independent", "applicable", - "approach", - "novo", - "success", - "experimental", - "desired", - "especially", + "type", + "engrailed", + "solution", "leading", + "formation", + "resulted", + "poor", + "parallel", + "demonstrated", "system", + "common", + "modeling", + "desired", + "method", "heterodimers", - "scaffold", - "protein", + "order", + "thermostabilizing", + "interfaces", + "mutations", + "de", + "oligomers", + "based", + "likely", + "structure", + "monomeric", + "thermostability", + "elucidating", + "report", + "serve", + "nmr", + "interactions", + "nature", + "function", + "understanding", "homodimers", - "previous", - "mechanisms", - "homodimer", "distinct", - "understanding", - "engrailed", - "homeodomain", - "level" + "studies", + "novel" ], "release_date":"2014-11-05", "publication":"\"Computational design and experimental verification of a symmetric protein homodimer\", Proc.Natl.Acad.Sci.USA, 112, 10714-10719", @@ -94017,13 +94195,13 @@ ], "subtitle":"Crystal structure of an engineered protein with ferredoxin fold, northeast structural genomics consortium (nesg) target or277", "tags":[ - "ferredoxin fold", - "northeast structural genomics consortium", - "structural genomics", "protein structure initiative", - "protein engineering", - "de novo protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", + "ferredoxin fold", + "protein engineering", + "structural genomics", "psi-biology" ], "keywords":[ @@ -94161,13 +94339,13 @@ ], "subtitle":"Crystal structure of an engineered protein with ferredoxin fold, northeast structural genomics consortium (nesg) target or276", "tags":[ - "ferredoxin fold", - "northeast structural genomics consortium", - "structural genomics", "protein structure initiative", - "protein engineering", - "de novo protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", + "ferredoxin fold", + "protein engineering", + "structural genomics", "psi-biology" ], "keywords":[ @@ -94316,45 +94494,45 @@ ], "subtitle":"Crystal structure of macrocycles containing a 17-23 (lv(phi)faed) and a 30-36 (aii(sar)l(orn)v)", "tags":[ - "de novo protein, protein binding", - "beta-hairpin", - "amyloid", "de novo protein", - "phe19 changed to p-iodo-phenylalanine", + "beta-sheet", + "beta-hairpin", "protein binding", - "beta-sheet" + "phe19 changed to p-iodo-phenylalanine", + "de novo protein, protein binding", + "amyloid" ], "keywords":[ - "oligomers", - "arrangement", - "associated", - "hexamer", + "form", + "central", + "disease", + "cavity", + "structures", "dodecamer", - "crystallizes", - "neurodegeneration", - "four", - "peptide", + "associate", + "oligomers", + "alzheimer", + "three", + "provide", "trimers", - "twisted", + "model", + "crystallizes", "working", + "derived", + "tetrahedral", + "neurodegeneration", "lattice", - "triangular", "highly", - "provide", - "alzheimer", + "arrangement", "two", + "triangular", "crystal", - "central", - "cavity", - "model", - "structures", - "tetrahedral", - "derived", - "three", - "form", - "disease", - "associate", - "consist" + "four", + "consist", + "associated", + "twisted", + "hexamer", + "peptide" ], "release_date":"2014-04-02", "publication":"\"X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from A beta (17-36)\", J.Am.Chem.Soc., 136, 5595-5598", @@ -94453,46 +94631,46 @@ ], "subtitle":"Crystal structure of macrocycles containing abeta 17-23 (lvffaed) and abeta 30-36 (aii(sar)l(orn)v)", "tags":[ + "de novo protein-protein binding complex", "amyloid beta-sheet mimic", - "de novo protein, protein binding", - "beta-hairpin", - "amyloid", "de novo protein", + "beta-sheet", + "beta-hairpin", "protein binding", - "de novo protein-protein binding complex", - "beta-sheet" + "de novo protein, protein binding", + "amyloid" ], "keywords":[ - "oligomers", - "arrangement", - "associated", - "hexamer", + "form", + "central", + "disease", + "cavity", + "structures", "dodecamer", - "crystallizes", - "neurodegeneration", - "four", - "peptide", + "associate", + "oligomers", + "alzheimer", + "three", + "provide", "trimers", - "twisted", + "model", + "crystallizes", "working", + "derived", + "tetrahedral", + "neurodegeneration", "lattice", - "triangular", "highly", - "provide", - "alzheimer", + "arrangement", "two", + "triangular", "crystal", - "central", - "cavity", - "model", - "structures", - "tetrahedral", - "derived", - "three", - "form", - "disease", - "associate", - "consist" + "four", + "consist", + "associated", + "twisted", + "hexamer", + "peptide" ], "release_date":"2014-04-02", "publication":"\"X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from A beta (17-36)\", J.Am.Chem.Soc., 136, 5595-5598", @@ -94591,44 +94769,44 @@ ], "subtitle":"Crystal structure of macrocycles containing abeta17-23 (lv(phi)(mea)aed) and abeta30-36 (aiigl(orn)v)", "tags":[ - "de novo protein, protein binding", - "beta-hairpin", - "amyloid", "de novo protein", + "beta-sheet", + "beta-hairpin", "protein binding", - "beta-sheet" + "de novo protein, protein binding", + "amyloid" ], "keywords":[ - "oligomers", - "arrangement", - "associated", - "hexamer", + "form", + "central", + "disease", + "cavity", + "structures", "dodecamer", - "crystallizes", - "neurodegeneration", - "four", - "peptide", + "associate", + "oligomers", + "alzheimer", + "three", + "provide", "trimers", - "twisted", + "model", + "crystallizes", "working", + "derived", + "tetrahedral", + "neurodegeneration", "lattice", - "triangular", "highly", - "provide", - "alzheimer", + "arrangement", "two", + "triangular", "crystal", - "central", - "cavity", - "model", - "structures", - "tetrahedral", - "derived", - "three", - "form", - "disease", - "associate", - "consist" + "four", + "consist", + "associated", + "twisted", + "hexamer", + "peptide" ], "release_date":"2014-04-02", "publication":"\"X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from A beta (17-36)\", J.Am.Chem.Soc., 136, 5595-5598", @@ -94727,44 +94905,44 @@ ], "subtitle":"Crystal structure of macrocycles containing abeta17-23 (lvf(mea)aed) and abeta30-36 (aiigl(orn)v)", "tags":[ - "de novo protein, protein binding", - "beta-hairpin", - "amyloid", "de novo protein", + "beta-sheet", + "beta-hairpin", "protein binding", - "beta-sheet" + "de novo protein, protein binding", + "amyloid" ], "keywords":[ - "oligomers", - "arrangement", - "associated", - "hexamer", + "form", + "central", + "disease", + "cavity", + "structures", "dodecamer", - "crystallizes", - "neurodegeneration", - "four", - "peptide", + "associate", + "oligomers", + "alzheimer", + "three", + "provide", "trimers", - "twisted", + "model", + "crystallizes", "working", + "derived", + "tetrahedral", + "neurodegeneration", "lattice", - "triangular", "highly", - "provide", - "alzheimer", + "arrangement", "two", + "triangular", "crystal", - "central", - "cavity", - "model", - "structures", - "tetrahedral", - "derived", - "three", - "form", - "disease", - "associate", - "consist" + "four", + "consist", + "associated", + "twisted", + "hexamer", + "peptide" ], "release_date":"2014-04-02", "publication":"\"X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from A beta (17-36)\", J.Am.Chem.Soc., 136, 5595-5598", @@ -94876,91 +95054,91 @@ "subtitle":"Structure of ankyrin repeat protein", "tags":[ "de novo protein", - "ankyrin", - "designed ankyrin repeats" + "designed ankyrin repeats", + "ankyrin" ], "keywords":[ + "escherichia", + "blocker", + "structural", + "show", "results", - "established", - "fermentation", - "suggest", "strategy", + "arac", + "reagents", + "protein", "permease", - "determination", - "designed", - "member", - "activator", - "crystal", - "potential", - "show", - "expression", - "typical", - "blocker", - "escherichia", - "operon", - "screen", - "novel", - "like", - "isolated", - "adapted", + "melr", + "binding", + "bacterial", "melb", - "suggesting", - "proteins", - "dna", - "combinatorial", - "specifically", - "assay", - "family", - "area", - "highly", - "binders", - "coding", - "preventing", - "assembly", + "transcription", + "forms", "motifs", - "facilitate", - "inhibits", - "melab", - "concave", - "tests", - "mela", "expected", - "functional", + "bioactive", "recognizing", - "reveals", - "factors", - "coli", - "reagents", - "may", - "useful", + "isolated", + "crystal", + "concave", + "preventing", + "operon", + "determination", "dimer", + "overall", + "dna", "specific", - "activity", - "negative", - "melibiose", - "surface", - "melr", - "completely", - "structural", - "diverse", + "coding", + "family", + "factors", "library", - "bioactive", - "overall", - "bacterial", - "fold", - "discovery", + "useful", + "mela", + "completely", + "positive", + "proteins", "constructed", + "member", "ankyrin", - "arac", - "positive", - "transcription", - "protein", - "vivo", + "may", + "combinatorial", "activation", + "highly", + "established", + "suggest", + "melab", + "activator", + "suggesting", + "like", + "inhibits", + "facilitate", + "surface", "inhibited", - "binding", - "forms", - "tool" + "diverse", + "binders", + "functional", + "melibiose", + "potential", + "assembly", + "fold", + "tool", + "coli", + "reveals", + "designed", + "assay", + "vivo", + "screen", + "area", + "specifically", + "typical", + "activity", + "negative", + "tests", + "fermentation", + "expression", + "discovery", + "adapted", + "novel" ], "release_date":"2015-03-25", "publication":"\"A transcription blocker isolated from a designed repeat protein combinatorial library by in vivo functional screen\", Sci Rep, 5, 8070-8070", @@ -95029,7 +95207,7 @@ }, { "sim":254.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":254.0, @@ -95037,7 +95215,7 @@ }, { "sim":254.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":254.0, @@ -95117,11 +95295,11 @@ }, { "sim":198.0, - "partner":"4gpm" + "partner":"4hb5" }, { "sim":198.0, - "partner":"4hb5" + "partner":"4gpm" }, { "sim":198.0, @@ -95165,11 +95343,11 @@ }, { "sim":194.0, - "partner":"4ydw" + "partner":"5kng" }, { "sim":194.0, - "partner":"5kng" + "partner":"4ydw" }, { "sim":194.0, @@ -95185,19 +95363,19 @@ }, { "sim":192.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":192.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":192.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":192.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":192.0, @@ -95205,43 +95383,43 @@ }, { "sim":192.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":192.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":192.0, - "partner":"7dnf" + "partner":"8qlb" }, { "sim":192.0, - "partner":"8ql6" + "partner":"8ql9" }, { "sim":192.0, - "partner":"8ql5" + "partner":"7dnf" }, { "sim":192.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":192.0, - "partner":"8ql7" + "partner":"7dng" }, { "sim":192.0, - "partner":"8qlb" + "partner":"8ql4" }, { "sim":192.0, - "partner":"7dng" + "partner":"8ql2" }, { "sim":192.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":190.0, @@ -95321,11 +95499,11 @@ }, { "sim":156.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":156.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":156.0, @@ -95351,6 +95529,10 @@ "sim":145.0, "partner":"2jab" }, + { + "sim":143.0, + "partner":"9glq" + }, { "sim":110.0, "partner":"2xen" @@ -95483,11 +95665,11 @@ }, { "sim":180.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":180.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":167.0, @@ -95559,15 +95741,15 @@ }, { "sim":138.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":138.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":138.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":135.0, @@ -95639,11 +95821,11 @@ }, { "sim":112.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":112.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":111.0, @@ -95771,15 +95953,15 @@ }, { "sim":91.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":91.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":91.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":91.0, @@ -95843,15 +96025,15 @@ }, { "sim":67.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":67.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":67.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":67.0, @@ -95901,6 +96083,10 @@ "sim":58.0, "partner":"2nyj" }, + { + "sim":56.0, + "partner":"8ycp" + }, { "sim":55.0, "partner":"3j5r" @@ -95984,81 +96170,81 @@ ], "subtitle":"Beta-trefoil designed by folding nucleus symmetric expansion (\"phifoil\")", "tags":[ - "folding nucleus symmetric expansion", - "beta-trefoil", + "de novo", "de novo protein", "protein design", - "de novo", + "beta-trefoil", + "folding nucleus symmetric expansion", "top-down symmetric deconstruction" ], "keywords":[ - "elegant", + "superior", + "typically", "analysis", - "evolution", - "expansion", - "proteome", "models", - "gene", - "exhibits", - "architecture", - "available", + "events", + "symmetry", + "design", + "naturally", + "efficient", + "structural", + "compared", + "fusion", "must", - "report", + "nearly", + "suggests", "de", - "stable", - "success", - "novo", - "principle", - "tractable", - "fold", - "efficient", - "repetition", - "typically", - "nucleus", - "properties", + "extant", "information", - "may", + "computationally", + "previously", "processes", - "resulting", - "suggests", - "capable", - "nucleating", - "motif", - "symmetric", - "duplicated", - "identified", - "evolutionary", - "nuclei", - "events", - "correct", + "gene", "potential", + "identified", + "properties", + "fold", "exact", - "design", - "redundant", + "report", + "provided", "invoke", + "resulting", + "nucleus", + "folding", + "exhibits", + "elegant", "protein", - "naturally", - "generates", - "given", "derived", - "superior", - "foldable", + "known", + "given", + "proteome", + "symmetric", "solution", - "symmetry", + "capable", + "motif", + "generates", + "nuclei", + "architecture", + "may", + "success", + "novo", + "applied", "sequence", - "fusion", - "computationally", + "available", + "duplicated", + "principle", + "evolution", + "stable", + "expansion", + "foldable", + "redundant", + "tractable", "evolved", - "extant", - "applied", "duplication", - "compared", - "nearly", - "known", - "folding", - "structural", - "provided", - "previously" + "correct", + "repetition", + "evolutionary", + "nucleating" ], "release_date":"2014-12-17", "publication":"\"Evolution and design of protein structure by folding nucleus symmetric expansion\", Structure, 22, 1377-1384", @@ -96171,10 +96357,6 @@ "sim":107.0, "partner":"1jt5" }, - { - "sim":106.0, - "partner":"3fj8" - }, { "sim":106.0, "partner":"1jt7" @@ -96195,17 +96377,21 @@ "sim":106.0, "partner":"1jy0" }, + { + "sim":106.0, + "partner":"3fj8" + }, { "sim":105.0, "partner":"1p63" }, { "sim":105.0, - "partner":"3fj9" + "partner":"3fgm" }, { "sim":105.0, - "partner":"3fgm" + "partner":"3fj9" }, { "sim":105.0, @@ -96267,10 +96453,6 @@ "sim":104.0, "partner":"2aqz" }, - { - "sim":104.0, - "partner":"1rg8" - }, { "sim":104.0, "partner":"3fja" @@ -96299,6 +96481,10 @@ "sim":104.0, "partner":"1jqz" }, + { + "sim":104.0, + "partner":"1rg8" + }, { "sim":104.0, "partner":"3ojm" @@ -96327,10 +96513,6 @@ "sim":103.0, "partner":"3cu1" }, - { - "sim":103.0, - "partner":"2k8r" - }, { "sim":103.0, "partner":"2ki6" @@ -96347,6 +96529,10 @@ "sim":103.0, "partner":"2ki4" }, + { + "sim":103.0, + "partner":"2k8r" + }, { "sim":103.0, "partner":"1evt" @@ -96381,11 +96567,11 @@ }, { "sim":103.0, - "partner":"1jtc" + "partner":"3fjd" }, { "sim":103.0, - "partner":"3fjd" + "partner":"1jtc" }, { "sim":103.0, @@ -96407,10 +96593,6 @@ "sim":102.0, "partner":"1dzc" }, - { - "sim":102.0, - "partner":"3baq" - }, { "sim":102.0, "partner":"3hal" @@ -96423,6 +96605,10 @@ "sim":102.0, "partner":"3cri" }, + { + "sim":102.0, + "partner":"3baq" + }, { "sim":101.0, "partner":"3bad" @@ -96473,11 +96659,11 @@ }, { "sim":98.0, - "partner":"3ba7" + "partner":"3bb2" }, { "sim":98.0, - "partner":"3bb2" + "partner":"3ba7" }, { "sim":97.0, @@ -96545,11 +96731,11 @@ }, { "sim":63.0, - "partner":"1iil" + "partner":"4oee" }, { "sim":63.0, - "partner":"4oee" + "partner":"1iil" }, { "sim":63.0, @@ -96651,9 +96837,9 @@ "subtitle":"X-ray structure of a designed cisk-px domain", "tags":[ "de novo protein", - "cisk-px", "evodesign", - "computational protein design" + "computational protein design", + "cisk-px" ], "keywords":[ "description", @@ -96910,86 +97096,86 @@ ], "subtitle":"Crystal structure of a computationally designed inhibitor of an epstein-barr viral bcl-2 protein", "tags":[ - "inhibitor", - "apoptosis", "viral protein-inhibitor complex", "complex", - "viral protein\/inhibitor" + "viral protein\/inhibitor", + "inhibitor", + "apoptosis" ], "keywords":[ - "limit", - "makes", - "generation", + "affinity", + "achieve", + "suppressed", + "genes", + "ebv", + "lymphoma", + "spread", + "disease", + "infected", + "design", + "induces", "toxic", - "prosurvival", - "called", - "delivered", "many", - "viruses", - "delivery", - "gene", - "virus", - "proteins", - "associated", + "hydrophobic", "specificity", - "growth", - "similar", - "host", - "generate", - "extended", - "survival", - "xenograft", - "manner", - "experimental", "intracellular", - "human", "homolog", - "bindi", - "optimization", - "may", - "cleft", + "additional", + "carrier", + "experimental", "used", - "spread", - "kill", - "provide", "current", - "recognizes", - "binds", - "lymphoma", - "induces", - "suppressed", - "target", - "picomolar", - "production", - "design", + "generation", + "cleft", + "xenograft", + "gene", + "survival", + "bhrf1", + "called", + "extended", + "provide", + "host", + "virus", + "block", + "exceptional", + "viruses", + "delivery", "model", - "conjugates", + "target", + "interactions", "protein", + "makes", + "optimization", + "contacts", + "proteins", + "lines", + "limit", + "delivered", "includes", - "interactions", - "exceptional", - "advantage", - "hydrophobic", - "selectively", - "bhrf1", + "kill", + "may", + "manner", "tumor", - "block", - "genes", + "cells", + "advantage", "compounds", - "computational", + "selectively", + "recognizes", "apoptosis", - "ebv", - "carrier", - "infected", - "additional", - "cells", - "affinity", + "picomolar", + "conjugates", + "bindi", + "binds", + "human", + "associated", + "growth", + "computational", "cancer", + "similar", + "generate", + "production", "novel", - "achieve", - "disease", - "contacts", - "lines" + "prosurvival" ], "release_date":"2014-07-09", "publication":"\"A computationally designed inhibitor of an epstein-barr viral bcl-2 protein induces apoptosis in infected cells\", Cell, 157, 1644-1656", @@ -97099,102 +97285,102 @@ "tags":[ "iodophenylalanine", "beta-2 microglobulin", - "amyloid", "de novo protein", - "hexamer" + "hexamer", + "amyloid" ], "keywords":[ - "containing", - "oligomers", - "developing", - "share", "trimer", + "dimers", + "demonstrates", + "disease", + "roadblock", + "structural", + "hydrophobic", + "resolution", + "amyloidogenic", + "single", + "information", + "families", + "theme", + "macrocyclic", + "core", + "three", "acid", - "peptide", + "developing", + "therapies", + "protein", + "illustrate", + "two", + "surrounded", + "formed", + "soluble", + "dimer", "alzheimer", "hexamers", - "mutation", + "trimers", + "relevant", + "derived", + "share", + "proteins", + "experiment", + "size", + "tetramers", "contains", - "features", - "ii", - "dodecamers", - "findings", "mixed", + "contain", + "subunits", + "cocrystallization", + "parkinson", + "features", "e", - "disease", - "associate", - "seven", - "toxic", - "chain", - "topology", - "proteins", - "paucity", + "pairs", + "peptide", "preventions", - "therapies", - "tetramers", - "dictate", - "amyloidogenic", - "illustrate", - "demonstrates", - "roadblock", - "cocrystallization", - "alter", - "experiment", - "structures", - "derived", + "toxic", + "recruits", + "another", "atomic", - "pairs", - "three", - "macrocyclic", - "size", - "form", + "topology", + "chain", "\u03b22m", - "second", - "heptapeptide", - "another", - "amino", - "common", - "families", - "oligomerization", - "resolution", - "information", - "trimers", - "fragments", - "relevant", - "dimer", - "parkinson", "provides", + "associate", + "species", + "paucity", + "also", + "oligomerization", + "amino", "type", - "crystallographic", - "core", - "soluble", - "present", - "hydrophobic", - "surrounded", - "theme", - "sequence", - "subunits", "formation", - "structural", + "dictate", + "sequence", + "common", + "peptides", + "present", "range", - "recruits", - "one", + "crystallographic", + "mutation", + "diabetes", "fundamental", - "pathology", + "form", + "heptapeptide", "octamers", - "also", - "single", - "peptides", - "species", - "diabetes", - "two", - "dimers", - "amyloid", - "protein", + "one", + "structures", + "fragments", + "oligomers", + "findings", + "pathology", "understanding", "diseases", - "formed", - "contain" + "dodecamers", + "amyloid", + "alter", + "seven", + "second", + "containing", + "ii" ], "release_date":"2015-05-06", "publication":"\"X-ray Crystallographic Structures of Oligomers of Peptides Derived from beta 2-Microglobulin\", J.Am.Chem.Soc., 137, 6304-6311", @@ -97305,104 +97491,104 @@ ], "subtitle":"Dodecamer formed by a macrocyclic peptide derived from beta-2-microglobulin (63-69) - (orn)yll(phi)yte(orn)kva(mva)avk", "tags":[ - "beta-2-microglobulin", - "amyloid", - "de novo protein", "macrocycle", - "dodecamer" + "de novo protein", + "beta-2-microglobulin", + "dodecamer", + "amyloid" ], "keywords":[ - "containing", - "oligomers", - "developing", - "share", "trimer", + "dimers", + "demonstrates", + "disease", + "roadblock", + "structural", + "hydrophobic", + "resolution", + "amyloidogenic", + "single", + "information", + "families", + "theme", + "macrocyclic", + "core", + "three", "acid", - "peptide", + "developing", + "therapies", + "protein", + "illustrate", + "two", + "surrounded", + "formed", + "soluble", + "dimer", "alzheimer", "hexamers", - "mutation", + "trimers", + "relevant", + "derived", + "share", + "proteins", + "experiment", + "size", + "tetramers", "contains", - "features", - "ii", - "dodecamers", - "findings", "mixed", + "contain", + "subunits", + "cocrystallization", + "parkinson", + "features", "e", - "disease", - "associate", - "seven", - "toxic", - "chain", - "topology", - "proteins", - "paucity", + "pairs", + "peptide", "preventions", - "therapies", - "tetramers", - "dictate", - "amyloidogenic", - "illustrate", - "demonstrates", - "roadblock", - "cocrystallization", - "alter", - "experiment", - "structures", - "derived", + "toxic", + "recruits", + "another", "atomic", - "pairs", - "three", - "macrocyclic", - "size", - "form", + "topology", + "chain", "\u03b22m", - "second", - "heptapeptide", - "another", - "amino", - "common", - "families", - "oligomerization", - "resolution", - "information", - "trimers", - "fragments", - "relevant", - "dimer", - "parkinson", "provides", + "associate", + "species", + "paucity", + "also", + "oligomerization", + "amino", "type", - "crystallographic", - "core", - "soluble", - "present", - "hydrophobic", - "surrounded", - "theme", - "sequence", - "subunits", "formation", - "structural", + "dictate", + "sequence", + "common", + "peptides", + "present", "range", - "recruits", - "one", + "crystallographic", + "mutation", + "diabetes", "fundamental", - "pathology", + "form", + "heptapeptide", "octamers", - "also", - "single", - "peptides", - "species", - "diabetes", - "two", - "dimers", - "amyloid", - "protein", + "one", + "structures", + "fragments", + "oligomers", + "findings", + "pathology", "understanding", "diseases", - "formed", - "contain" + "dodecamers", + "amyloid", + "alter", + "seven", + "second", + "containing", + "ii" ], "release_date":"2015-05-06", "publication":"\"X-ray Crystallographic Structures of Oligomers of Peptides Derived from beta 2-Microglobulin\", J.Am.Chem.Soc., 137, 6304-6311", @@ -97468,7 +97654,7 @@ ], "seq_max_sim_designed":{ "sim":30.0, - "partner":"4p4x" + "partner":"4p4v" }, "seq_max_sim_natural":[ @@ -97529,104 +97715,104 @@ ], "subtitle":"Dodecamer formed by a macrocyclic peptide derived from beta-2-microglobulin (63-69) - (orn)yll(phi)yte(orn)kva(mle)avk", "tags":[ - "beta-2-microglobulin", - "amyloid", "macrocycle", "de novo protein", - "dodecamer" + "beta-2-microglobulin", + "dodecamer", + "amyloid" ], "keywords":[ - "containing", - "oligomers", - "developing", - "share", "trimer", + "dimers", + "demonstrates", + "disease", + "roadblock", + "structural", + "hydrophobic", + "resolution", + "amyloidogenic", + "single", + "information", + "families", + "theme", + "macrocyclic", + "core", + "three", "acid", - "peptide", + "developing", + "therapies", + "protein", + "illustrate", + "two", + "surrounded", + "formed", + "soluble", + "dimer", "alzheimer", "hexamers", - "mutation", + "trimers", + "relevant", + "derived", + "share", + "proteins", + "experiment", + "size", + "tetramers", "contains", - "features", - "ii", - "dodecamers", - "findings", "mixed", + "contain", + "subunits", + "cocrystallization", + "parkinson", + "features", "e", - "disease", - "associate", - "seven", - "toxic", - "chain", - "topology", - "proteins", - "paucity", + "pairs", + "peptide", "preventions", - "therapies", - "tetramers", - "dictate", - "amyloidogenic", - "illustrate", - "demonstrates", - "roadblock", - "cocrystallization", - "alter", - "experiment", - "structures", - "derived", + "toxic", + "recruits", + "another", "atomic", - "pairs", - "three", - "macrocyclic", - "size", - "form", + "topology", + "chain", "\u03b22m", - "second", - "heptapeptide", - "another", - "amino", - "common", - "families", - "oligomerization", - "resolution", - "information", - "trimers", - "fragments", - "relevant", - "dimer", - "parkinson", "provides", + "associate", + "species", + "paucity", + "also", + "oligomerization", + "amino", "type", - "crystallographic", - "core", - "soluble", - "present", - "hydrophobic", - "surrounded", - "theme", - "sequence", - "subunits", "formation", - "structural", + "dictate", + "sequence", + "common", + "peptides", + "present", "range", - "recruits", - "one", + "crystallographic", + "mutation", + "diabetes", "fundamental", - "pathology", + "form", + "heptapeptide", "octamers", - "also", - "single", - "peptides", - "species", - "diabetes", - "two", - "dimers", - "amyloid", - "protein", + "one", + "structures", + "fragments", + "oligomers", + "findings", + "pathology", "understanding", "diseases", - "formed", - "contain" + "dodecamers", + "amyloid", + "alter", + "seven", + "second", + "containing", + "ii" ], "release_date":"2015-05-06", "publication":"\"X-ray Crystallographic Structures of Oligomers of Peptides Derived from beta 2-Microglobulin\", J.Am.Chem.Soc., 137, 6304-6311", @@ -97749,104 +97935,104 @@ ], "subtitle":"Hexamer formed by a macrocyclic peptide derived from beta-2-microglobulin (63-69) - (orn)yll(phi)yte(orn)kvt(maa)tvk", "tags":[ - "beta-2-microglobulin", - "amyloid", - "de novo protein", "macrocycle", - "hexamer" + "de novo protein", + "beta-2-microglobulin", + "hexamer", + "amyloid" ], "keywords":[ - "containing", - "oligomers", - "developing", - "share", "trimer", + "dimers", + "demonstrates", + "disease", + "roadblock", + "structural", + "hydrophobic", + "resolution", + "amyloidogenic", + "single", + "information", + "families", + "theme", + "macrocyclic", + "core", + "three", "acid", - "peptide", + "developing", + "therapies", + "protein", + "illustrate", + "two", + "surrounded", + "formed", + "soluble", + "dimer", "alzheimer", "hexamers", - "mutation", + "trimers", + "relevant", + "derived", + "share", + "proteins", + "experiment", + "size", + "tetramers", "contains", - "features", - "ii", - "dodecamers", - "findings", "mixed", + "contain", + "subunits", + "cocrystallization", + "parkinson", + "features", "e", - "disease", - "associate", - "seven", - "toxic", - "chain", - "topology", - "proteins", - "paucity", + "pairs", + "peptide", "preventions", - "therapies", - "tetramers", - "dictate", - "amyloidogenic", - "illustrate", - "demonstrates", - "roadblock", - "cocrystallization", - "alter", - "experiment", - "structures", - "derived", + "toxic", + "recruits", + "another", "atomic", - "pairs", - "three", - "macrocyclic", - "size", - "form", + "topology", + "chain", "\u03b22m", - "second", - "heptapeptide", - "another", - "amino", - "common", - "families", - "oligomerization", - "resolution", - "information", - "trimers", - "fragments", - "relevant", - "dimer", - "parkinson", "provides", + "associate", + "species", + "paucity", + "also", + "oligomerization", + "amino", "type", - "crystallographic", - "core", - "soluble", - "present", - "hydrophobic", - "surrounded", - "theme", - "sequence", - "subunits", "formation", - "structural", + "dictate", + "sequence", + "common", + "peptides", + "present", "range", - "recruits", - "one", + "crystallographic", + "mutation", + "diabetes", "fundamental", - "pathology", + "form", + "heptapeptide", "octamers", - "also", - "single", - "peptides", - "species", - "diabetes", - "two", - "dimers", - "amyloid", - "protein", + "one", + "structures", + "fragments", + "oligomers", + "findings", + "pathology", "understanding", "diseases", - "formed", - "contain" + "dodecamers", + "amyloid", + "alter", + "seven", + "second", + "containing", + "ii" ], "release_date":"2015-05-06", "publication":"\"X-ray Crystallographic Structures of Oligomers of Peptides Derived from beta 2-Microglobulin\", J.Am.Chem.Soc., 137, 6304-6311", @@ -97958,103 +98144,103 @@ "subtitle":"Octomer formed by a macrocyclic peptide derived from beta-2-microglobulin (63-69) - (orn)yll(phi)yte(orn)kvt(mva)tvk", "tags":[ "beta-2 microglobulin", - "amyloid", "de novo protein", + "beta-sheet", "octamer", - "beta-sheet" + "amyloid" ], "keywords":[ - "containing", - "oligomers", - "developing", - "share", "trimer", + "dimers", + "demonstrates", + "disease", + "roadblock", + "structural", + "hydrophobic", + "resolution", + "amyloidogenic", + "single", + "information", + "families", + "theme", + "macrocyclic", + "core", + "three", "acid", - "peptide", + "developing", + "therapies", + "protein", + "illustrate", + "two", + "surrounded", + "formed", + "soluble", + "dimer", "alzheimer", "hexamers", - "mutation", + "trimers", + "relevant", + "derived", + "share", + "proteins", + "experiment", + "size", + "tetramers", "contains", - "features", - "ii", - "dodecamers", - "findings", "mixed", + "contain", + "subunits", + "cocrystallization", + "parkinson", + "features", "e", - "disease", - "associate", - "seven", - "toxic", - "chain", - "topology", - "proteins", - "paucity", + "pairs", + "peptide", "preventions", - "therapies", - "tetramers", - "dictate", - "amyloidogenic", - "illustrate", - "demonstrates", - "roadblock", - "cocrystallization", - "alter", - "experiment", - "structures", - "derived", + "toxic", + "recruits", + "another", "atomic", - "pairs", - "three", - "macrocyclic", - "size", - "form", + "topology", + "chain", "\u03b22m", - "second", - "heptapeptide", - "another", - "amino", - "common", - "families", - "oligomerization", - "resolution", - "information", - "trimers", - "fragments", - "relevant", - "dimer", - "parkinson", "provides", + "associate", + "species", + "paucity", + "also", + "oligomerization", + "amino", "type", - "crystallographic", - "core", - "soluble", - "present", - "hydrophobic", - "surrounded", - "theme", - "sequence", - "subunits", "formation", - "structural", + "dictate", + "sequence", + "common", + "peptides", + "present", "range", - "recruits", - "one", + "crystallographic", + "mutation", + "diabetes", "fundamental", - "pathology", + "form", + "heptapeptide", "octamers", - "also", - "single", - "peptides", - "species", - "diabetes", - "two", - "dimers", - "amyloid", - "protein", + "one", + "structures", + "fragments", + "oligomers", + "findings", + "pathology", "understanding", "diseases", - "formed", - "contain" + "dodecamers", + "amyloid", + "alter", + "seven", + "second", + "containing", + "ii" ], "release_date":"2015-05-06", "publication":"\"X-ray Crystallographic Structures of Oligomers of Peptides Derived from beta 2-Microglobulin\", J.Am.Chem.Soc., 137, 6304-6311", @@ -98183,81 +98369,81 @@ ], "subtitle":"Crystal structure of the computationally designed transmembrane metallotransporter with 4-bromophenylalanine in octyl glucoside", "tags":[ - "transporter", - "transmembrane", "de novo protein", "4-bromophenylalanine", + "transporter", + "transmembrane", "de-novo designed" ], "keywords":[ - "conduction", - "sites", - "weakly", - "antiported", - "overall", - "predefined", + "membranes", + "co", "chemistry", + "ca", + "designed", + "cooperativity", + "transports", + "form", + "path", + "individual", + "designing", + "design", + "interacting", + "dynamic", + "metal", + "structural", + "indicate", + "antiported", + "formed", + "principles", + "show", + "biology", "functional", - "membranes", - "membrane", - "proteins", + "flux", + "first", "represents", - "grand", - "magnetic", - "helices", + "overall", + "properties", + "predefined", "report", - "concentration", - "metal", - "challenge", - "ions", - "along", + "conduction", "experiments", + "transition", "crystallography", - "cooperativity", - "designed", + "magnetic", + "bind", + "gradients", + "tightly", + "membrane", "illustrate", - "diffuse", - "interacting", - "interface", - "feasibility", - "two", - "nuclear", "interact", - "flux", - "gradients", - "bundle", - "domains", - "vesicle", - "design", - "show", - "individual", - "helical", - "bind", - "dynamic", - "path", - "negative", + "proteins", + "sites", + "binding", "across", - "designing", "solution", - "pairs", + "helical", + "ions", + "feasibility", + "weakly", + "concentration", + "domains", + "negative", "resonance", + "interface", + "vesicle", + "contain", + "two", + "along", + "nuclear", + "helices", + "challenge", "zn", - "tightly", - "ca", - "biology", - "indicate", + "bundle", + "grand", "protons", - "transition", - "form", - "co", - "principles", - "first", - "transports", - "binding", - "structural", - "formed", - "contain", - "properties" + "pairs", + "diffuse" ], "release_date":"2014-12-24", "publication":"\"De novo design of a transmembrane Zn2+-transporting four-helix bundle\", Science, 346, 1520-1524", @@ -98290,29 +98476,29 @@ "seq_thr_sim_designed":[ { "sim":50.0, - "partner":"4p6l" + "partner":"4p6k" }, { "sim":50.0, - "partner":"4p6k" + "partner":"2muz" }, { "sim":50.0, - "partner":"2muz" + "partner":"4p6l" } ], "seq_thr_sim_natural":[ ], "struct_thr_sim_designed":[ - { - "sim":0.9745000005, - "partner":"4p6l" - }, { "sim":0.9847999811, "partner":"4p6k" }, + { + "sim":0.9745000005, + "partner":"4p6l" + }, { "sim":0.9542000294, "partner":"7nfi" @@ -98323,7 +98509,7 @@ ], "seq_max_sim_designed":{ "sim":50.0, - "partner":"4p6l" + "partner":"4p6k" }, "seq_max_sim_natural":[ @@ -98400,81 +98586,81 @@ ], "subtitle":"Crystal structure of the computationally designed transmembrane metallotransporter with 4-bromophenylalanine in lipidic cubic phase", "tags":[ + "de novo protein", "lipidic cubic phase", "transporter", "transmembrane", - "de novo protein", "de-novo designed" ], "keywords":[ - "conduction", - "sites", - "weakly", - "antiported", - "overall", - "predefined", + "membranes", + "co", "chemistry", + "ca", + "designed", + "cooperativity", + "transports", + "form", + "path", + "individual", + "designing", + "design", + "interacting", + "dynamic", + "metal", + "structural", + "indicate", + "antiported", + "formed", + "principles", + "show", + "biology", "functional", - "membranes", - "membrane", - "proteins", + "flux", + "first", "represents", - "grand", - "magnetic", - "helices", + "overall", + "properties", + "predefined", "report", - "concentration", - "metal", - "challenge", - "ions", - "along", + "conduction", "experiments", + "transition", "crystallography", - "cooperativity", - "designed", + "magnetic", + "bind", + "gradients", + "tightly", + "membrane", "illustrate", - "diffuse", - "interacting", - "interface", - "feasibility", - "two", - "nuclear", "interact", - "flux", - "gradients", - "bundle", - "domains", - "vesicle", - "design", - "show", - "individual", - "helical", - "bind", - "dynamic", - "path", - "negative", + "proteins", + "sites", + "binding", "across", - "designing", "solution", - "pairs", + "helical", + "ions", + "feasibility", + "weakly", + "concentration", + "domains", + "negative", "resonance", + "interface", + "vesicle", + "contain", + "two", + "along", + "nuclear", + "helices", + "challenge", "zn", - "tightly", - "ca", - "biology", - "indicate", + "bundle", + "grand", "protons", - "transition", - "form", - "co", - "principles", - "first", - "transports", - "binding", - "structural", - "formed", - "contain", - "properties" + "pairs", + "diffuse" ], "release_date":"2014-12-24", "publication":"\"De novo design of a transmembrane Zn2+-transporting four-helix bundle\", Science, 346, 1520-1524", @@ -98507,15 +98693,15 @@ "seq_thr_sim_designed":[ { "sim":50.0, - "partner":"4p6j" + "partner":"2muz" }, { "sim":50.0, - "partner":"4p6l" + "partner":"4p6j" }, { "sim":50.0, - "partner":"2muz" + "partner":"4p6l" } ], "seq_thr_sim_natural":[ @@ -98536,7 +98722,7 @@ ], "seq_max_sim_designed":{ "sim":50.0, - "partner":"4p6j" + "partner":"2muz" }, "seq_max_sim_natural":[ @@ -98613,80 +98799,80 @@ ], "subtitle":"Crystal structure of the computationally designed transmembrane metallotransporter in octyl glucoside", "tags":[ - "de novo protein", - "de-novo designed", "transporter", - "transmembrane" + "de novo protein", + "transmembrane", + "de-novo designed" ], "keywords":[ - "conduction", - "sites", - "weakly", - "antiported", - "overall", - "predefined", + "membranes", + "co", "chemistry", + "ca", + "designed", + "cooperativity", + "transports", + "form", + "path", + "individual", + "designing", + "design", + "interacting", + "dynamic", + "metal", + "structural", + "indicate", + "antiported", + "formed", + "principles", + "show", + "biology", "functional", - "membranes", - "membrane", - "proteins", + "flux", + "first", "represents", - "grand", - "magnetic", - "helices", + "overall", + "properties", + "predefined", "report", - "concentration", - "metal", - "challenge", - "ions", - "along", + "conduction", "experiments", + "transition", "crystallography", - "cooperativity", - "designed", + "magnetic", + "bind", + "gradients", + "tightly", + "membrane", "illustrate", - "diffuse", - "interacting", - "interface", - "feasibility", - "two", - "nuclear", "interact", - "flux", - "gradients", - "bundle", - "domains", - "vesicle", - "design", - "show", - "individual", - "helical", - "bind", - "dynamic", - "path", - "negative", + "proteins", + "sites", + "binding", "across", - "designing", "solution", - "pairs", + "helical", + "ions", + "feasibility", + "weakly", + "concentration", + "domains", + "negative", "resonance", + "interface", + "vesicle", + "contain", + "two", + "along", + "nuclear", + "helices", + "challenge", "zn", - "tightly", - "ca", - "biology", - "indicate", + "bundle", + "grand", "protons", - "transition", - "form", - "co", - "principles", - "first", - "transports", - "binding", - "structural", - "formed", - "contain", - "properties" + "pairs", + "diffuse" ], "release_date":"2014-12-24", "publication":"\"De novo design of a transmembrane Zn2+-transporting four-helix bundle\", Science, 346, 1520-1524", @@ -98719,15 +98905,15 @@ "seq_thr_sim_designed":[ { "sim":50.0, - "partner":"4p6j" + "partner":"4p6k" }, { "sim":50.0, - "partner":"4p6k" + "partner":"2muz" }, { "sim":50.0, - "partner":"2muz" + "partner":"4p6j" } ], "seq_thr_sim_natural":[ @@ -98748,7 +98934,7 @@ ], "seq_max_sim_designed":{ "sim":50.0, - "partner":"4p6j" + "partner":"4p6k" }, "seq_max_sim_natural":[ @@ -98820,80 +99006,80 @@ ], "subtitle":"Crystal structure of designed cppr-polyg protein", "tags":[ - "de novo protein, rna binding protein", "de novo protein", "designer rna-binding proteins; pentatricopeptide repeat; synthetic biology; rna-protein interactions", + "de novo protein, rna binding protein", "rna binding protein" ], "keywords":[ - "predicted", - "stability", - "diverse", - "ppr", "elucidate", - "control", - "pentatricopeptide", - "great", - "importance", - "studies", - "proteins", - "restricted", - "gene", + "engineering", + "recognition", + "design", + "mechanisms", + "structural", + "insights", + "atomic", + "mechanistic", + "repeat", + "association", + "diverse", + "observed", + "structurally", + "structures", + "provides", + "suggests", + "natural", + "understand", "regulation", - "aspects", - "use", - "modes", "rna", - "strategy", - "although", - "tools", - "artificial", - "understand", - "modular", - "programmed", - "mode", + "modes", + "biological", + "gene", "residues", - "modelling", - "highly", + "eukaryotic", + "provided", + "great", + "although", + "new", + "strategy", "functions", - "robust", - "suggests", - "recognition", + "target", + "control", + "ppr", "nature", + "interactions", "inconsistencies", - "engineering", - "provides", - "target", - "domains", - "observed", - "holds", - "design", - "mechanistic", "basis", - "structures", - "interactions", - "promise", - "eukaryotic", - "mechanisms", - "natural", - "association", - "recent", - "atomic", - "structurally", - "repeat", - "biological", - "insights", "understanding", - "computational", + "stability", + "modelling", + "proteins", + "mode", + "binding", + "programmed", + "pentatricopeptide", "metabolism", + "artificial", + "use", + "consensus", + "modular", + "holds", "cells", - "binding", - "structural", + "insoluble", + "domains", + "predicted", + "highly", + "promise", + "aspects", + "studies", + "recent", "create", - "consensus", - "provided", - "new", - "insoluble" + "restricted", + "computational", + "importance", + "tools", + "robust" ], "release_date":"2014-12-24", "publication":"\"An artificial PPR scaffold for programmable RNA recognition\", Nat Commun, 5, 5729-5729", @@ -99007,80 +99193,80 @@ ], "subtitle":"Crystal structure of designed cppr-nre protein", "tags":[ - "de novo protein, rna binding protein", "de novo protein", "designer rna-binding proteins; pentatricopeptide repeat; synthetic biology; rna-protein interactions", + "de novo protein, rna binding protein", "rna binding protein" ], "keywords":[ - "predicted", - "stability", - "diverse", - "ppr", "elucidate", - "control", - "pentatricopeptide", - "great", - "importance", - "studies", - "proteins", - "restricted", - "gene", + "engineering", + "recognition", + "design", + "mechanisms", + "structural", + "insights", + "atomic", + "mechanistic", + "repeat", + "association", + "diverse", + "observed", + "structurally", + "structures", + "provides", + "suggests", + "natural", + "understand", "regulation", - "aspects", - "use", - "modes", "rna", - "strategy", - "although", - "tools", - "artificial", - "understand", - "modular", - "programmed", - "mode", + "modes", + "biological", + "gene", "residues", - "modelling", - "highly", + "eukaryotic", + "provided", + "great", + "although", + "new", + "strategy", "functions", - "robust", - "suggests", - "recognition", + "target", + "control", + "ppr", "nature", + "interactions", "inconsistencies", - "engineering", - "provides", - "target", - "domains", - "observed", - "holds", - "design", - "mechanistic", "basis", - "structures", - "interactions", - "promise", - "eukaryotic", - "mechanisms", - "natural", - "association", - "recent", - "atomic", - "structurally", - "repeat", - "biological", - "insights", "understanding", - "computational", + "stability", + "modelling", + "proteins", + "mode", + "binding", + "programmed", + "pentatricopeptide", "metabolism", + "artificial", + "use", + "consensus", + "modular", + "holds", "cells", - "binding", - "structural", + "insoluble", + "domains", + "predicted", + "highly", + "promise", + "aspects", + "studies", + "recent", "create", - "consensus", - "provided", - "new", - "insoluble" + "restricted", + "computational", + "importance", + "tools", + "robust" ], "release_date":"2014-12-24", "publication":"\"An artificial PPR scaffold for programmable RNA recognition\", Nat Commun, 5, 5729-5729", @@ -99194,80 +99380,80 @@ ], "subtitle":"Crystal structure of designed (semet)-cppr-nre protein", "tags":[ - "de novo protein, rna binding protein", "de novo protein", "designer rna-binding proteins; pentatricopeptide repeat; synthetic biology; rna-protein interactions", + "de novo protein, rna binding protein", "rna binding protein" ], "keywords":[ - "predicted", - "stability", - "diverse", - "ppr", "elucidate", - "control", - "pentatricopeptide", - "great", - "importance", - "studies", - "proteins", - "restricted", - "gene", + "engineering", + "recognition", + "design", + "mechanisms", + "structural", + "insights", + "atomic", + "mechanistic", + "repeat", + "association", + "diverse", + "observed", + "structurally", + "structures", + "provides", + "suggests", + "natural", + "understand", "regulation", - "aspects", - "use", - "modes", "rna", - "strategy", - "although", - "tools", - "artificial", - "understand", - "modular", - "programmed", - "mode", + "modes", + "biological", + "gene", "residues", - "modelling", - "highly", + "eukaryotic", + "provided", + "great", + "although", + "new", + "strategy", "functions", - "robust", - "suggests", - "recognition", + "target", + "control", + "ppr", "nature", + "interactions", "inconsistencies", - "engineering", - "provides", - "target", - "domains", - "observed", - "holds", - "design", - "mechanistic", "basis", - "structures", - "interactions", - "promise", - "eukaryotic", - "mechanisms", - "natural", - "association", - "recent", - "atomic", - "structurally", - "repeat", - "biological", - "insights", "understanding", - "computational", + "stability", + "modelling", + "proteins", + "mode", + "binding", + "programmed", + "pentatricopeptide", "metabolism", + "artificial", + "use", + "consensus", + "modular", + "holds", "cells", - "binding", - "structural", + "insoluble", + "domains", + "predicted", + "highly", + "promise", + "aspects", + "studies", + "recent", "create", - "consensus", - "provided", - "new", - "insoluble" + "restricted", + "computational", + "importance", + "tools", + "robust" ], "release_date":"2014-12-24", "publication":"\"An artificial PPR scaffold for programmable RNA recognition\", Nat Commun, 5, 5729-5729", @@ -99381,76 +99567,76 @@ ], "subtitle":"A de novo designed pentameric coiled coil cc-pent", "tags":[ - "protein design", "de novo protein", + "alpha-helical barrel", "coiled coil", - "alpha-helical barrel" + "protein design" ], "keywords":[ - "predicted", - "general", - "coiled", - "scope", + "central", + "defined", + "models", + "design", + "sequences", + "challenging", "require", - "considerable", - "designs", "many", + "fit", + "methods", + "observed", "descriptions", - "channels", - "models", - "helices", - "accessible", - "remain", - "defined", - "barrels", + "structures", "de", - "novo", - "solutions", - "class", - "four", - "offer", - "considerations", - "state", - "fold", - "unobserved", - "challenging", - "resulting", - "prescribed", - "diameters", - "problem", - "folds", - "methods", - "modeling", "geometrical", - "geometric", - "new", - "crystal", - "central", - "combine", - "match", - "atomistic", - "design", + "possible", "furthermore", - "sequences", + "accessible", "scoring", - "observed", - "chemically", - "structures", + "fold", + "hitherto", + "solutions", + "new", + "resulting", + "prescribed", + "state", "protein", - "present", - "coils", - "routes", - "promising", + "chemically", + "exploring", "function", - "fit", + "class", "silico", - "hitherto", + "considerations", "oligomer", - "possible", "unseen", - "facilitate", + "routes", + "coiled", + "considerable", + "general", + "novo", + "promising", + "predicted", + "remain", + "channels", + "match", + "scope", + "combine", + "diameters", + "present", + "offer", + "problem", + "crystal", + "coils", + "helices", + "four", + "modeling", + "designs", + "atomistic", "related", - "exploring" + "unobserved", + "facilitate", + "folds", + "barrels", + "geometric" ], "release_date":"2014-10-22", "publication":"\"Computational design of water-soluble alpha-helical barrels\", Science, 346, 485-488", @@ -99527,6 +99713,10 @@ "sim":1.0, "partner":"7nfn" }, + { + "sim":1.0, + "partner":"6zt1" + }, { "sim":1.0, "partner":"4pna" @@ -99539,18 +99729,6 @@ "sim":1.0, "partner":"5ezc" }, - { - "sim":1.0, - "partner":"6zt1" - }, - { - "sim":1.0, - "partner":"5ez8" - }, - { - "sim":0.9575999975, - "partner":"7nfk" - }, { "sim":0.9578999877, "partner":"8b16" @@ -99561,7 +99739,11 @@ }, { "sim":1.0, - "partner":"7nfp" + "partner":"5ez8" + }, + { + "sim":0.9575999975, + "partner":"7nfk" }, { "sim":0.9550999999, @@ -99573,15 +99755,15 @@ }, { "sim":1.0, - "partner":"7nfg" + "partner":"7nfp" }, { "sim":1.0, - "partner":"7nff" + "partner":"7nfg" }, { "sim":1.0, - "partner":"7nfi" + "partner":"7nff" }, { "sim":1.0, @@ -99598,6 +99780,10 @@ { "sim":0.9778000116, "partner":"7nfo" + }, + { + "sim":1.0, + "partner":"7nfi" } ], "struct_thr_sim_natural":[ @@ -99676,76 +99862,76 @@ ], "subtitle":"A de novo designed hexameric coiled coil cc-hex2", "tags":[ - "protein design", "de novo protein", + "alpha-helical barrel", "coiled coil", - "alpha-helical barrel" + "protein design" ], "keywords":[ - "predicted", - "general", - "coiled", - "scope", + "central", + "defined", + "models", + "design", + "sequences", + "challenging", "require", - "considerable", - "designs", "many", + "fit", + "methods", + "observed", "descriptions", - "channels", - "models", - "helices", - "accessible", - "remain", - "defined", - "barrels", + "structures", "de", - "novo", - "solutions", - "class", - "four", - "offer", - "considerations", - "state", - "fold", - "unobserved", - "challenging", - "resulting", - "prescribed", - "diameters", - "problem", - "folds", - "methods", - "modeling", "geometrical", - "geometric", - "new", - "crystal", - "central", - "combine", - "match", - "atomistic", - "design", + "possible", "furthermore", - "sequences", + "accessible", "scoring", - "observed", - "chemically", - "structures", + "fold", + "hitherto", + "solutions", + "new", + "resulting", + "prescribed", + "state", "protein", - "present", - "coils", - "routes", - "promising", + "chemically", + "exploring", "function", - "fit", + "class", "silico", - "hitherto", + "considerations", "oligomer", - "possible", "unseen", - "facilitate", + "routes", + "coiled", + "considerable", + "general", + "novo", + "promising", + "predicted", + "remain", + "channels", + "match", + "scope", + "combine", + "diameters", + "present", + "offer", + "problem", + "crystal", + "coils", + "helices", + "four", + "modeling", + "designs", + "atomistic", "related", - "exploring" + "unobserved", + "facilitate", + "folds", + "barrels", + "geometric" ], "release_date":"2014-10-22", "publication":"\"Computational design of water-soluble alpha-helical barrels\", Science, 346, 485-488", @@ -99820,23 +100006,23 @@ }, { "sim":1.0, - "partner":"6xy1" + "partner":"5ez8" }, { - "sim":1.0, - "partner":"5ez8" + "sim":0.9987999797, + "partner":"7nfj" }, { "sim":1.0, - "partner":"6g6f" + "partner":"7nfk" }, { - "sim":0.9987999797, - "partner":"7nfj" + "sim":1.0, + "partner":"6xy1" }, { "sim":1.0, - "partner":"7nfk" + "partner":"6g6f" }, { "sim":1.0, @@ -99856,11 +100042,11 @@ }, { "sim":1.0, - "partner":"6eik" + "partner":"7bau" }, { "sim":1.0, - "partner":"7bau" + "partner":"6eik" }, { "sim":0.9970999956, @@ -99868,20 +100054,24 @@ }, { "sim":1.0, - "partner":"7nfn" + "partner":"7nfl" }, { "sim":1.0, - "partner":"7nfh" + "partner":"7nfn" }, { "sim":1.0, - "partner":"7nfl" + "partner":"7nfh" }, { "sim":1.0, "partner":"5ezc" }, + { + "sim":0.996999979, + "partner":"6g6b" + }, { "sim":0.9975000024, "partner":"6zt1" @@ -99890,10 +100080,6 @@ "sim":0.9936000109, "partner":"6g6a" }, - { - "sim":0.996999979, - "partner":"6g6b" - }, { "sim":0.9563999772, "partner":"5eze" @@ -99922,22 +100108,22 @@ "sim":0.9933000207, "partner":"7nff" }, - { - "sim":0.9975000024, - "partner":"7nfm" - }, { "sim":0.9979000092, "partner":"7nfi" }, { - "sim":0.9907000065, - "partner":"7bo9" + "sim":0.9975000024, + "partner":"7nfm" }, { "sim":1.0, "partner":"6xxz" }, + { + "sim":0.9907000065, + "partner":"7bo9" + }, { "sim":0.9987999797, "partner":"5eza" @@ -100059,76 +100245,76 @@ ], "subtitle":"A de novo designed heptameric coiled coil cc-hept", "tags":[ - "protein design", "de novo protein", + "alpha-helical barrel", "coiled coil", - "alpha-helical barrel" + "protein design" ], "keywords":[ - "predicted", - "general", - "coiled", - "scope", + "central", + "defined", + "models", + "design", + "sequences", + "challenging", "require", - "considerable", - "designs", "many", + "fit", + "methods", + "observed", "descriptions", - "channels", - "models", - "helices", - "accessible", - "remain", - "defined", - "barrels", + "structures", "de", - "novo", - "solutions", - "class", - "four", - "offer", - "considerations", - "state", - "fold", - "unobserved", - "challenging", - "resulting", - "prescribed", - "diameters", - "problem", - "folds", - "methods", - "modeling", "geometrical", - "geometric", - "new", - "crystal", - "central", - "combine", - "match", - "atomistic", - "design", + "possible", "furthermore", - "sequences", + "accessible", "scoring", - "observed", - "chemically", - "structures", + "fold", + "hitherto", + "solutions", + "new", + "resulting", + "prescribed", + "state", "protein", - "present", - "coils", - "routes", - "promising", + "chemically", + "exploring", "function", - "fit", + "class", "silico", - "hitherto", + "considerations", "oligomer", - "possible", "unseen", - "facilitate", + "routes", + "coiled", + "considerable", + "general", + "novo", + "promising", + "predicted", + "remain", + "channels", + "match", + "scope", + "combine", + "diameters", + "present", + "offer", + "problem", + "crystal", + "coils", + "helices", + "four", + "modeling", + "designs", + "atomistic", "related", - "exploring" + "unobserved", + "facilitate", + "folds", + "barrels", + "geometric" ], "release_date":"2014-10-22", "publication":"\"Computational design of water-soluble alpha-helical barrels\", Science, 346, 485-488", @@ -100203,11 +100389,11 @@ }, { "sim":1.0, - "partner":"8a09" + "partner":"6eiz" }, { "sim":1.0, - "partner":"6eiz" + "partner":"8a09" }, { "sim":1.0, @@ -100215,19 +100401,19 @@ }, { "sim":1.0, - "partner":"7nfo" + "partner":"7nfg" }, { "sim":1.0, - "partner":"8b16" + "partner":"7nfo" }, { "sim":1.0, - "partner":"6zt1" + "partner":"8b16" }, { "sim":1.0, - "partner":"7nfg" + "partner":"6zt1" }, { "sim":1.0, @@ -100267,15 +100453,15 @@ }, { "sim":1.0, - "partner":"5ezc" + "partner":"6g6g" }, { "sim":1.0, - "partner":"6g6f" + "partner":"5ezc" }, { "sim":1.0, - "partner":"6g6g" + "partner":"6g6f" }, { "sim":1.0, @@ -100317,14 +100503,14 @@ "sim":1.0, "partner":"7baw" }, - { - "sim":0.9957000017, - "partner":"6g6b" - }, { "sim":0.9988999963, "partner":"6g6a" }, + { + "sim":0.9957000017, + "partner":"6g6b" + }, { "sim":1.0, "partner":"6g6d" @@ -100357,6 +100543,10 @@ "sim":0.991599977, "partner":"7bo9" }, + { + "sim":0.9703999758, + "partner":"9gf2" + }, { "sim":1.0, "partner":"7bo8" @@ -100377,7 +100567,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"7bim" + "partner":"7nff" }, "struct_max_sim_natural":[ @@ -100442,78 +100632,78 @@ ], "subtitle":"A de novo designed hexameric coiled coil cc-hex3", "tags":[ - "peptide", - "protein design", - "de novo protein", "coiled coil", + "de novo protein", + "artificially designed - often synthetic", "alpha-helical barrel", - "artificially designed - often synthetic" + "protein design", + "peptide" ], "keywords":[ - "predicted", - "general", - "coiled", - "scope", + "central", + "defined", + "models", + "design", + "sequences", + "challenging", "require", - "considerable", - "designs", "many", + "fit", + "methods", + "observed", "descriptions", - "channels", - "models", - "helices", - "accessible", - "remain", - "defined", - "barrels", + "structures", "de", - "novo", - "solutions", - "class", - "four", - "offer", - "considerations", - "state", - "fold", - "unobserved", - "challenging", - "resulting", - "prescribed", - "diameters", - "problem", - "folds", - "methods", - "modeling", "geometrical", - "geometric", - "new", - "crystal", - "central", - "combine", - "match", - "atomistic", - "design", + "possible", "furthermore", - "sequences", + "accessible", "scoring", - "observed", - "chemically", - "structures", + "fold", + "hitherto", + "solutions", + "new", + "resulting", + "prescribed", + "state", "protein", - "present", - "coils", - "routes", - "promising", + "chemically", + "exploring", "function", - "fit", + "class", "silico", - "hitherto", + "considerations", "oligomer", - "possible", "unseen", - "facilitate", + "routes", + "coiled", + "considerable", + "general", + "novo", + "promising", + "predicted", + "remain", + "channels", + "match", + "scope", + "combine", + "diameters", + "present", + "offer", + "problem", + "crystal", + "coils", + "helices", + "four", + "modeling", + "designs", + "atomistic", "related", - "exploring" + "unobserved", + "facilitate", + "folds", + "barrels", + "geometric" ], "release_date":"2014-10-22", "publication":"\"Computational design of water-soluble alpha-helical barrels\", Science, 346, 485-488", @@ -100627,77 +100817,77 @@ ], "subtitle":"A de novo designed pentameric coiled coil cc-pent_variant", "tags":[ - "protein design", - "de novo protein", "coiled coil", + "de novo protein", + "artificially designed - often synthetic", "alpha-helical barrel", - "artificially designed - often synthetic" + "protein design" ], "keywords":[ - "predicted", - "general", - "coiled", - "scope", + "central", + "defined", + "models", + "design", + "sequences", + "challenging", "require", - "considerable", - "designs", "many", + "fit", + "methods", + "observed", "descriptions", - "channels", - "models", - "helices", - "accessible", - "remain", - "defined", - "barrels", + "structures", "de", - "novo", - "solutions", - "class", - "four", - "offer", - "considerations", - "state", - "fold", - "unobserved", - "challenging", - "resulting", - "prescribed", - "diameters", - "problem", - "folds", - "methods", - "modeling", "geometrical", - "geometric", - "new", - "crystal", - "central", - "combine", - "match", - "atomistic", - "design", + "possible", "furthermore", - "sequences", + "accessible", "scoring", - "observed", - "chemically", - "structures", + "fold", + "hitherto", + "solutions", + "new", + "resulting", + "prescribed", + "state", "protein", - "present", - "coils", - "routes", - "promising", + "chemically", + "exploring", "function", - "fit", + "class", "silico", - "hitherto", + "considerations", "oligomer", - "possible", "unseen", - "facilitate", + "routes", + "coiled", + "considerable", + "general", + "novo", + "promising", + "predicted", + "remain", + "channels", + "match", + "scope", + "combine", + "diameters", + "present", + "offer", + "problem", + "crystal", + "coils", + "helices", + "four", + "modeling", + "designs", + "atomistic", "related", - "exploring" + "unobserved", + "facilitate", + "folds", + "barrels", + "geometric" ], "release_date":"2014-10-22", "publication":"\"Computational design of water-soluble alpha-helical barrels\", Science, 346, 485-488", @@ -100734,10 +100924,18 @@ ], "struct_thr_sim_designed":[ + { + "sim":0.9894000292, + "partner":"6xy1" + }, { "sim":0.996999979, "partner":"6xy0" }, + { + "sim":0.9516000152, + "partner":"9gf2" + }, { "sim":0.9875000119, "partner":"6z0m" @@ -100749,10 +100947,6 @@ { "sim":0.9685000181, "partner":"7bey" - }, - { - "sim":0.9894000292, - "partner":"6xy1" } ], "struct_thr_sim_natural":[ @@ -100852,12 +101046,12 @@ ], "subtitle":"Crystal structure of engineered protein, northeast structural genomics consortium target or465", "tags":[ + "nesg", + "de novo protein", "northeast structural genomics consortium", + "psi-biology", "structural genomics", - "protein structure initiative", - "de novo protein", - "nesg", - "psi-biology" + "protein structure initiative" ], "keywords":[ "description", @@ -101026,10 +101220,6 @@ "sim":139.0, "partner":"2omx" }, - { - "sim":139.0, - "partner":"1o6t" - }, { "sim":139.0, "partner":"1o6v" @@ -101042,6 +101232,10 @@ "sim":139.0, "partner":"1o6s" }, + { + "sim":139.0, + "partner":"1o6t" + }, { "sim":138.0, "partner":"2omt" @@ -101098,6 +101292,14 @@ "sim":116.0, "partner":"8wvy" }, + { + "sim":116.0, + "partner":"8xt9" + }, + { + "sim":116.0, + "partner":"8xum" + }, { "sim":111.0, "partner":"3zyj" @@ -101182,10 +101384,6 @@ "sim":96.0, "partner":"1sq0" }, - { - "sim":96.0, - "partner":"3pmh" - }, { "sim":96.0, "partner":"1p9a" @@ -101198,6 +101396,10 @@ "sim":96.0, "partner":"1ook" }, + { + "sim":96.0, + "partner":"3pmh" + }, { "sim":96.0, "partner":"4c2b" @@ -101282,10 +101484,6 @@ "sim":85.0, "partner":"3oja" }, - { - "sim":85.0, - "partner":"3w3j" - }, { "sim":85.0, "partner":"3w3k" @@ -101310,6 +101508,10 @@ "sim":85.0, "partner":"3w3g" }, + { + "sim":85.0, + "partner":"3w3j" + }, { "sim":82.0, "partner":"8rts" @@ -101372,11 +101574,11 @@ }, { "sim":77.0, - "partner":"8wee" + "partner":"8web" }, { "sim":77.0, - "partner":"8web" + "partner":"8wee" }, { "sim":76.0, @@ -101416,23 +101618,23 @@ }, { "sim":68.0, - "partner":"8wry" + "partner":"8wqt" }, { "sim":68.0, - "partner":"8wsa" + "partner":"8wry" }, { "sim":68.0, - "partner":"8wqt" + "partner":"8wsa" }, { "sim":68.0, - "partner":"3vq2" + "partner":"3vq1" }, { "sim":68.0, - "partner":"3vq1" + "partner":"3vq2" }, { "sim":67.0, @@ -101617,14 +101819,14 @@ ], "subtitle":"Crystal structure of engineered protein. northeast structural genomics consortium (nesg) target or464", "tags":[ - "northeast structural genomics consortium", "or464", - "structural genomics", - "protein structure initiative", - "de novo protein", + "engineered protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", "psi-biology", - "engineered protein" + "structural genomics", + "protein structure initiative" ], "keywords":[ "description", @@ -101785,10 +101987,6 @@ "sim":145.0, "partner":"2omy" }, - { - "sim":142.0, - "partner":"1o6t" - }, { "sim":142.0, "partner":"1o6v" @@ -101801,6 +101999,10 @@ "sim":142.0, "partner":"1o6s" }, + { + "sim":142.0, + "partner":"1o6t" + }, { "sim":141.0, "partner":"3m19" @@ -101941,10 +102143,6 @@ "sim":93.0, "partner":"1sq0" }, - { - "sim":93.0, - "partner":"3pmh" - }, { "sim":93.0, "partner":"1p9a" @@ -101957,6 +102155,10 @@ "sim":93.0, "partner":"1ook" }, + { + "sim":93.0, + "partner":"3pmh" + }, { "sim":93.0, "partner":"4c2b" @@ -101975,11 +102177,11 @@ }, { "sim":92.0, - "partner":"8vh4" + "partner":"8vh5" }, { "sim":92.0, - "partner":"8vh5" + "partner":"8vh4" }, { "sim":89.0, @@ -101999,11 +102201,11 @@ }, { "sim":89.0, - "partner":"3ul7" + "partner":"3ul9" }, { "sim":89.0, - "partner":"3ul9" + "partner":"3ul7" }, { "sim":89.0, @@ -102021,10 +102223,6 @@ "sim":87.0, "partner":"8rts" }, - { - "sim":85.0, - "partner":"3w3j" - }, { "sim":85.0, "partner":"3w3k" @@ -102049,6 +102247,10 @@ "sim":85.0, "partner":"3w3g" }, + { + "sim":85.0, + "partner":"3w3j" + }, { "sim":84.0, "partner":"3cig" @@ -102075,11 +102277,11 @@ }, { "sim":80.0, - "partner":"8wee" + "partner":"8web" }, { "sim":80.0, - "partner":"8web" + "partner":"8wee" }, { "sim":78.0, @@ -102103,15 +102305,15 @@ }, { "sim":75.0, - "partner":"8wo1" + "partner":"3fxi" }, { "sim":75.0, - "partner":"3fxi" + "partner":"8wta" }, { "sim":75.0, - "partner":"8wta" + "partner":"8wo1" }, { "sim":75.0, @@ -102151,23 +102353,23 @@ }, { "sim":68.0, - "partner":"8wry" + "partner":"8wqt" }, { "sim":68.0, - "partner":"8wsa" + "partner":"8wry" }, { "sim":68.0, - "partner":"8wqt" + "partner":"8wsa" }, { "sim":68.0, - "partner":"3vq2" + "partner":"3vq1" }, { "sim":68.0, - "partner":"3vq1" + "partner":"3vq2" }, { "sim":66.0, @@ -102328,14 +102530,14 @@ ], "subtitle":"Crystal structure of engineered protein. northeast structural genomics consortium target or494", "tags":[ - "northeast structural genomics consortium", + "de novo", "or494", - "structural genomics", - "protein structure initiative", - "de novo protein", "nesg", - "de novo", - "psi-biology" + "de novo protein", + "northeast structural genomics consortium", + "psi-biology", + "structural genomics", + "protein structure initiative" ], "keywords":[ "description", @@ -102496,91 +102698,91 @@ "subtitle":"Crystal structure of a unique ankyrin", "tags":[ "de novo protein", - "designed ankyrin repeats", - "domain swap" + "domain swap", + "designed ankyrin repeats" ], "keywords":[ + "escherichia", + "blocker", + "structural", + "show", "results", - "established", - "fermentation", - "suggest", "strategy", + "arac", + "reagents", + "protein", "permease", - "determination", - "designed", - "member", - "activator", - "crystal", - "potential", - "show", - "expression", - "typical", - "blocker", - "escherichia", - "operon", - "screen", - "novel", - "like", - "isolated", - "adapted", + "melr", + "binding", + "bacterial", "melb", - "suggesting", - "proteins", - "dna", - "combinatorial", - "specifically", - "assay", - "family", - "area", - "highly", - "binders", - "coding", - "preventing", - "assembly", + "transcription", + "forms", "motifs", - "facilitate", - "inhibits", - "melab", - "concave", - "tests", - "mela", "expected", - "functional", + "bioactive", "recognizing", - "reveals", - "factors", - "coli", - "reagents", - "may", - "useful", + "isolated", + "crystal", + "concave", + "preventing", + "operon", + "determination", "dimer", + "overall", + "dna", "specific", - "activity", - "negative", - "melibiose", - "surface", - "melr", - "completely", - "structural", - "diverse", + "coding", + "family", + "factors", "library", - "bioactive", - "overall", - "bacterial", - "fold", - "discovery", + "useful", + "mela", + "completely", + "positive", + "proteins", "constructed", + "member", "ankyrin", - "arac", - "positive", - "transcription", - "protein", - "vivo", + "may", + "combinatorial", "activation", + "highly", + "established", + "suggest", + "melab", + "activator", + "suggesting", + "like", + "inhibits", + "facilitate", + "surface", "inhibited", - "binding", - "forms", - "tool" + "diverse", + "binders", + "functional", + "melibiose", + "potential", + "assembly", + "fold", + "tool", + "coli", + "reveals", + "designed", + "assay", + "vivo", + "screen", + "area", + "specifically", + "typical", + "activity", + "negative", + "tests", + "fermentation", + "expression", + "discovery", + "adapted", + "novel" ], "release_date":"2015-05-06", "publication":"\"A transcription blocker isolated from a designed repeat protein combinatorial library by in vivo functional screen\", Sci Rep, 5, 8070-8070", @@ -102649,7 +102851,7 @@ }, { "sim":259.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":259.0, @@ -102657,7 +102859,7 @@ }, { "sim":259.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":258.0, @@ -102765,11 +102967,11 @@ }, { "sim":200.0, - "partner":"4j7w" + "partner":"5knh" }, { "sim":200.0, - "partner":"5knh" + "partner":"4j7w" }, { "sim":199.0, @@ -102837,19 +103039,19 @@ }, { "sim":189.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":189.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":189.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":189.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":189.0, @@ -102857,35 +103059,35 @@ }, { "sim":189.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":189.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":189.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":189.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":189.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":189.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":189.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":189.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":189.0, @@ -102945,11 +103147,11 @@ }, { "sim":153.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":153.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":151.0, @@ -102963,6 +103165,10 @@ "sim":150.0, "partner":"9f24" }, + { + "sim":149.0, + "partner":"9glq" + }, { "sim":147.0, "partner":"9f23" @@ -103103,11 +103309,11 @@ }, { "sim":179.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":179.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":176.0, @@ -103167,15 +103373,15 @@ }, { "sim":148.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":148.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":148.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":145.0, @@ -103267,11 +103473,11 @@ }, { "sim":117.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":117.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":115.0, @@ -103515,15 +103721,15 @@ }, { "sim":72.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":72.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":72.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":72.0, @@ -103601,6 +103807,10 @@ "sim":61.0, "partner":"3j5q" }, + { + "sim":61.0, + "partner":"8ycp" + }, { "sim":58.0, "partner":"3w9f" @@ -103697,94 +103907,94 @@ "subtitle":"Crystal structure of 6xtyr\/pv2: de novo designed beta-trefoil architecture with symmetric primary structure (l22y\/l44y\/l64y\/l85y\/l108y\/l132y, primitive version 2)", "tags":[ "beta-trefoil", - "simplified protein design", "de novo protein", - "prebiotic protein" + "prebiotic protein", + "simplified protein design" ], "keywords":[ - "evolution", - "evidence", - "cradle", - "results", - "part", "v", - "thus", - "viewpoint", - "codon", - "acid", - "test", + "requirement", + "hydrophobic", + "exclusively", "candidate", - "designed", + "number", + "key", + "single", + "late", + "core", "substitutions", - "instead", - "enriched", - "proteogenesis", - "enhancement", + "eliminating", + "acid", "earliest", - "e", - "aromatic", - "adapted", - "availability", - "structured", + "results", + "polypeptide", + "folding", + "protein", + "facilitated", + "lines", + "comprising", + "subsequent", + "polypeptides", + "test", + "systems", "original", - "incorporation", + "substitution", + "effects", + "10", + "g", "l", - "requirement", - "number", - "step", + "p", "requiring", - "living", - "exclusively", - "advantage", - "table", - "effects", + "step", + "thus", + "regard", "transition", - "halophilic", - "systems", - "facilitate", - "early", - "substitution", - "amino", - "subsequent", - "conditions", "curious", - "hypothesis", - "acids", - "10", - "niche", - "g", - "late", + "cradle", + "evidence", + "part", + "capable", "several", - "core", - "polypeptide", - "hydrophobic", - "facilitated", - "eliminating", - "indicate", - "origin", - "could", - "key", - "prebiotic", - "critical", - "halophile", + "advantage", "aspects", - "single", - "capable", - "primitive", - "addition", + "evolution", + "incorporation", + "e", + "hypothesis", + "facilitate", "set", - "selective", - "regard", - "protein", + "critical", + "halophile", + "living", + "viewpoint", + "instead", "environment", - "evaluated", + "selective", + "addition", + "amino", + "origin", + "conditions", "compelling", - "comprising", - "polypeptides", - "folding", - "p", - "emerging", - "lines" + "evaluated", + "enriched", + "halophilic", + "table", + "could", + "designed", + "aromatic", + "indicate", + "prebiotic", + "codon", + "niche", + "enhancement", + "structured", + "availability", + "primitive", + "proteogenesis", + "early", + "acids", + "adapted", + "emerging" ], "release_date":"2015-01-14", "publication":"\"A single aromatic core mutation converts a designed \"primitive\" protein from halophile to mesophile folding\", Protein Sci., 24, 27-37", @@ -103891,11 +104101,11 @@ }, { "sim":89.0, - "partner":"1jtc" + "partner":"3fjd" }, { "sim":89.0, - "partner":"3fjd" + "partner":"1jtc" }, { "sim":89.0, @@ -103929,22 +104139,6 @@ "sim":88.0, "partner":"1jt5" }, - { - "sim":87.0, - "partner":"3ba7" - }, - { - "sim":87.0, - "partner":"3fj8" - }, - { - "sim":87.0, - "partner":"1rg8" - }, - { - "sim":87.0, - "partner":"3baq" - }, { "sim":87.0, "partner":"3fj9" @@ -104009,17 +104203,13 @@ "sim":87.0, "partner":"3crg" }, - { - "sim":87.0, - "partner":"1jy0" - }, { "sim":87.0, "partner":"3crh" }, { "sim":87.0, - "partner":"1jt4" + "partner":"1jy0" }, { "sim":87.0, @@ -104033,10 +104223,30 @@ "sim":87.0, "partner":"3fjj" }, + { + "sim":87.0, + "partner":"1jt4" + }, { "sim":87.0, "partner":"1jqz" }, + { + "sim":87.0, + "partner":"3ba7" + }, + { + "sim":87.0, + "partner":"3fj8" + }, + { + "sim":87.0, + "partner":"1rg8" + }, + { + "sim":87.0, + "partner":"3baq" + }, { "sim":86.0, "partner":"2aqz" @@ -104185,10 +104395,6 @@ "sim":79.0, "partner":"1dzc" }, - { - "sim":79.0, - "partner":"2k8r" - }, { "sim":79.0, "partner":"2ki6" @@ -104205,6 +104411,10 @@ "sim":79.0, "partner":"2ki4" }, + { + "sim":79.0, + "partner":"2k8r" + }, { "sim":79.0, "partner":"2rq9" @@ -104271,11 +104481,11 @@ }, { "sim":57.0, - "partner":"1iil" + "partner":"4oee" }, { "sim":57.0, - "partner":"4oee" + "partner":"1iil" }, { "sim":57.0, @@ -104392,94 +104602,94 @@ "subtitle":"Crystal structure of 6xtrp\/pv2: de novo designed beta-trefoil architecture with symmetric primary structure (l22w\/l44w\/l64w\/l85w\/l108w\/l132w his primitive version 2)", "tags":[ "beta-trefoil", - "simplified protein design", "de novo protein", - "prebiotic protein" + "prebiotic protein", + "simplified protein design" ], "keywords":[ - "evolution", - "evidence", - "cradle", - "results", - "part", "v", - "thus", - "viewpoint", - "codon", - "acid", - "test", + "requirement", + "hydrophobic", + "exclusively", "candidate", - "designed", + "number", + "key", + "single", + "late", + "core", "substitutions", - "instead", - "enriched", - "proteogenesis", - "enhancement", + "eliminating", + "acid", "earliest", - "e", - "aromatic", - "adapted", - "availability", - "structured", + "results", + "polypeptide", + "folding", + "protein", + "facilitated", + "lines", + "comprising", + "subsequent", + "polypeptides", + "test", + "systems", "original", - "incorporation", + "substitution", + "effects", + "10", + "g", "l", - "requirement", - "number", - "step", + "p", "requiring", - "living", - "exclusively", - "advantage", - "table", - "effects", + "step", + "thus", + "regard", "transition", - "halophilic", - "systems", - "facilitate", - "early", - "substitution", - "amino", - "subsequent", - "conditions", "curious", - "hypothesis", - "acids", - "10", - "niche", - "g", - "late", + "cradle", + "evidence", + "part", + "capable", "several", - "core", - "polypeptide", - "hydrophobic", - "facilitated", - "eliminating", - "indicate", - "origin", - "could", - "key", - "prebiotic", - "critical", - "halophile", + "advantage", "aspects", - "single", - "capable", - "primitive", - "addition", + "evolution", + "incorporation", + "e", + "hypothesis", + "facilitate", "set", - "selective", - "regard", - "protein", + "critical", + "halophile", + "living", + "viewpoint", + "instead", "environment", - "evaluated", + "selective", + "addition", + "amino", + "origin", + "conditions", "compelling", - "comprising", - "polypeptides", - "folding", - "p", - "emerging", - "lines" + "evaluated", + "enriched", + "halophilic", + "table", + "could", + "designed", + "aromatic", + "indicate", + "prebiotic", + "codon", + "niche", + "enhancement", + "structured", + "availability", + "primitive", + "proteogenesis", + "early", + "acids", + "adapted", + "emerging" ], "release_date":"2015-01-14", "publication":"\"A single aromatic core mutation converts a designed \"primitive\" protein from halophile to mesophile folding\", Protein Sci., 24, 27-37", @@ -104598,11 +104808,11 @@ }, { "sim":85.0, - "partner":"1jtc" + "partner":"3fjd" }, { "sim":85.0, - "partner":"3fjd" + "partner":"1jtc" }, { "sim":85.0, @@ -104624,10 +104834,6 @@ "sim":85.0, "partner":"1jt5" }, - { - "sim":84.0, - "partner":"3baq" - }, { "sim":84.0, "partner":"2hwa" @@ -104669,20 +104875,12 @@ "partner":"3cri" }, { - "sim":83.0, - "partner":"2aqz" - }, - { - "sim":83.0, - "partner":"3ba7" - }, - { - "sim":83.0, - "partner":"3fj8" + "sim":84.0, + "partner":"3baq" }, { "sim":83.0, - "partner":"1rg8" + "partner":"2aqz" }, { "sim":83.0, @@ -104736,13 +104934,17 @@ "sim":83.0, "partner":"1jy0" }, + { + "sim":83.0, + "partner":"3fjj" + }, { "sim":83.0, "partner":"1jt4" }, { "sim":83.0, - "partner":"3fjj" + "partner":"3fjk" }, { "sim":83.0, @@ -104750,7 +104952,15 @@ }, { "sim":83.0, - "partner":"3fjk" + "partner":"3ba7" + }, + { + "sim":83.0, + "partner":"3fj8" + }, + { + "sim":83.0, + "partner":"1rg8" }, { "sim":82.0, @@ -104880,10 +105090,6 @@ "sim":76.0, "partner":"1dzc" }, - { - "sim":76.0, - "partner":"2k8r" - }, { "sim":76.0, "partner":"2ki6" @@ -104900,6 +105106,10 @@ "sim":76.0, "partner":"2ki4" }, + { + "sim":76.0, + "partner":"2k8r" + }, { "sim":76.0, "partner":"2rq9" @@ -104966,11 +105176,11 @@ }, { "sim":54.0, - "partner":"1iil" + "partner":"4oee" }, { "sim":54.0, - "partner":"4oee" + "partner":"1iil" }, { "sim":54.0, @@ -105110,110 +105320,110 @@ ], "subtitle":"Computational design of co-assembling protein-dna nanowires", "tags":[ + "de novo design\/dna", "double-stranded dna", - "helix-turn-helix", - "dna-binding protein", "de novo design-dna complex", - "de novo design\/dna" + "helix-turn-helix", + "dna-binding protein" ], "keywords":[ - "work", - "remained", - "drosophila", - "use", - "crystallography", - "peptide", - "allowing", - "proposed", - "mixing", - "irregular", - "interactions", - "bind", - "bulk", - "fluorescence", - "building", - "successes", - "achieve", - "nanotechnologists", - "formed", - "composed", - "proteins", - "biomolecular", - "dna", - "presented", - "interface", - "used", - "nanowire", - "decade", - "materials", - "aptamers", - "nanostructures", - "biocompatibility", + "molecular", "whose", + "development", "exclusively", - "onto", - "foundation", - "nanomaterial", - "atomic", - "force", - "assembly", - "molecules", - "origami", - "framework", - "reported", - "molecular", - "functional", + "mixing", "via", - "acids", - "dsdna", - "interest", - "classes", - "blocks", - "design", - "nanoparticle", - "elusive", - "using", + "framework", + "delivery", + "new", + "width", + "protein", + "microscopy", + "sophisticated", + "composed", + "two", "applications", - "explored", + "nanotechnologists", + "using", + "achieve", + "complex", + "nanostructures", + "engineered", + "homeodomain", + "enh", "confirming", + "formed", + "nanoparticle", + "interest", + "bulk", + "dna", "epitopes", - "versatility", - "computing", - "range", "great", + "lays", + "aptamers", + "bind", + "dsdna", + "nanowire", + "blocks", + "proteins", "sites", - "sophisticated", + "use", + "interface", + "elusive", + "computational", + "allowing", + "characterize", + "peptide", + "design", + "onto", + "atomic", + "work", + "classes", + "used", "past", - "lays", - "delivery", - "despite", - "arrangement", + "functional", + "computing", + "assembly", + "drosophila", + "driven", + "explored", "nucleic", + "biomolecular", "wide", - "driven", - "hybrid", - "drug", - "width", - "peptides", - "engineered", - "characterize", - "two", - "homodimerization", + "engrailed", "incorporating", - "mechanism", - "enh", - "dimerized", + "foundation", "spontaneously", - "protein", - "microscopy", - "complex", - "development", "varying", - "computational", - "engrailed", - "homeodomain", - "create", - "new" + "homodimerization", + "building", + "reported", + "dimerized", + "arrangement", + "peptides", + "hybrid", + "range", + "mechanism", + "decade", + "materials", + "proposed", + "fluorescence", + "nanomaterial", + "biocompatibility", + "irregular", + "crystallography", + "interactions", + "drug", + "force", + "molecules", + "remained", + "presented", + "origami", + "acids", + "despite", + "versatility", + "successes", + "create" ], "release_date":"2015-07-29", "publication":"\"Computational design of co-assembling protein-DNA nanowires\", Nature, 525, 230-233", @@ -105324,64 +105534,64 @@ "leucine rich repeat (lrr) protein" ], "keywords":[ - "power", - "general", - "control", - "combining", - "designs", - "junction", + "curvature", + "designed", + "surface", + "finally", + "component", "molecular", - "proteins", - "greatly", "complementarity", - "unique", - "approach", - "generate", - "appropriately", - "modules", - "scaffolds", - "reagents", + "recognition", + "junction", "polymerized", - "adjust", - "shape", - "designed", - "finally", - "apply", - "would", - "generated", - "different", "interest", + "creation", + "therapeutics", + "structures", + "first", + "different", + "combining", + "important", + "apply", + "scaffolds", + "shape", + "new", + "precisely", + "target", "surfaces", + "reagents", + "control", + "protein", + "curvatures", "illustrate", - "shapes", - "recognition", - "precisely", - "crystal", + "controlling", + "approach", + "blocks", + "proteins", + "would", + "binding", + "modules", + "greatly", "connect", "ability", - "target", - "set", + "general", + "shapes", + "adjust", "scaffold", + "building", "match", - "blocks", - "controlling", - "creation", - "therapeutics", - "protein", - "structures", - "surface", - "describe", + "generated", "constant", - "curvature", - "component", - "building", - "first", + "power", + "appropriately", + "crystal", + "describe", + "unique", "second", - "curvatures", - "binding", + "designs", "facilitate", - "important", - "new" + "generate", + "set" ], "release_date":"2015-01-14", "publication":"\"Control of repeat-protein curvature by computational protein design\", Nat.Struct.Mol.Biol., 22, 167-174", @@ -105530,10 +105740,6 @@ "sim":177.0, "partner":"2omy" }, - { - "sim":175.0, - "partner":"1o6t" - }, { "sim":175.0, "partner":"1o6v" @@ -105546,6 +105752,10 @@ "sim":175.0, "partner":"1o6s" }, + { + "sim":175.0, + "partner":"1o6t" + }, { "sim":168.0, "partner":"4fho" @@ -105648,19 +105858,15 @@ }, { "sim":60.0, - "partner":"3w3j" - }, - { - "sim":60.0, - "partner":"4r07" + "partner":"3w3k" }, { "sim":60.0, - "partner":"3w3k" + "partner":"3wn4" }, { "sim":60.0, - "partner":"3wn4" + "partner":"4r07" }, { "sim":60.0, @@ -105698,6 +105904,10 @@ "sim":60.0, "partner":"3w3g" }, + { + "sim":60.0, + "partner":"3w3j" + }, { "sim":58.0, "partner":"2jqd" @@ -105736,15 +105946,15 @@ }, { "sim":53.0, - "partner":"8wo1" + "partner":"3fxi" }, { "sim":53.0, - "partner":"3fxi" + "partner":"8wta" }, { "sim":53.0, - "partner":"8wta" + "partner":"8wo1" }, { "sim":52.0, @@ -105776,11 +105986,11 @@ }, { "sim":50.0, - "partner":"8vh4" + "partner":"8vh5" }, { "sim":50.0, - "partner":"8vh5" + "partner":"8vh4" } ], "struct_thr_sim_designed":[ @@ -105873,64 +106083,64 @@ "leucine rich repeat (lrr) protein" ], "keywords":[ - "power", - "general", - "control", - "combining", - "designs", - "junction", + "curvature", + "designed", + "surface", + "finally", + "component", "molecular", - "proteins", - "greatly", "complementarity", - "unique", - "approach", - "generate", - "appropriately", - "modules", - "scaffolds", - "reagents", + "recognition", + "junction", "polymerized", - "adjust", - "shape", - "designed", - "finally", - "apply", - "would", - "generated", - "different", "interest", + "creation", + "therapeutics", + "structures", + "first", + "different", + "combining", + "important", + "apply", + "scaffolds", + "shape", + "new", + "precisely", + "target", "surfaces", + "reagents", + "control", + "protein", + "curvatures", "illustrate", - "shapes", - "recognition", - "precisely", - "crystal", + "controlling", + "approach", + "blocks", + "proteins", + "would", + "binding", + "modules", + "greatly", "connect", "ability", - "target", - "set", + "general", + "shapes", + "adjust", "scaffold", + "building", "match", - "blocks", - "controlling", - "creation", - "therapeutics", - "protein", - "structures", - "surface", - "describe", + "generated", "constant", - "curvature", - "component", - "building", - "first", + "power", + "appropriately", + "crystal", + "describe", + "unique", "second", - "curvatures", - "binding", + "designs", "facilitate", - "important", - "new" + "generate", + "set" ], "release_date":"2015-01-07", "publication":"\"Control of repeat-protein curvature by computational protein design\", Nat.Struct.Mol.Biol., 22, 167-174", @@ -106079,10 +106289,6 @@ "sim":176.0, "partner":"2omx" }, - { - "sim":176.0, - "partner":"1o6t" - }, { "sim":176.0, "partner":"1o6v" @@ -106095,6 +106301,10 @@ "sim":176.0, "partner":"1o6s" }, + { + "sim":176.0, + "partner":"1o6t" + }, { "sim":175.0, "partner":"2omt" @@ -106159,6 +106369,14 @@ "sim":123.0, "partner":"8wvy" }, + { + "sim":123.0, + "partner":"8xt9" + }, + { + "sim":123.0, + "partner":"8xum" + }, { "sim":120.0, "partner":"2o6r" @@ -106231,10 +106449,6 @@ "sim":99.0, "partner":"3oja" }, - { - "sim":98.0, - "partner":"3w3j" - }, { "sim":98.0, "partner":"3w3k" @@ -106267,6 +106481,10 @@ "sim":98.0, "partner":"3w3g" }, + { + "sim":98.0, + "partner":"3w3j" + }, { "sim":97.0, "partner":"4qdh" @@ -106359,10 +106577,6 @@ "sim":87.0, "partner":"1sq0" }, - { - "sim":87.0, - "partner":"3pmh" - }, { "sim":87.0, "partner":"1p9a" @@ -106375,6 +106589,10 @@ "sim":87.0, "partner":"1ook" }, + { + "sim":87.0, + "partner":"3pmh" + }, { "sim":87.0, "partner":"4c2b" @@ -106413,11 +106631,11 @@ }, { "sim":85.0, - "partner":"8wee" + "partner":"8web" }, { "sim":85.0, - "partner":"8web" + "partner":"8wee" }, { "sim":84.0, @@ -106465,11 +106683,11 @@ }, { "sim":77.0, - "partner":"3ul7" + "partner":"3ul9" }, { "sim":77.0, - "partner":"3ul9" + "partner":"3ul7" }, { "sim":77.0, @@ -106581,23 +106799,23 @@ }, { "sim":66.0, - "partner":"8wry" + "partner":"8wqt" }, { "sim":66.0, - "partner":"8wsa" + "partner":"8wry" }, { "sim":66.0, - "partner":"8wqt" + "partner":"8wsa" }, { "sim":66.0, - "partner":"3vq2" + "partner":"3vq1" }, { "sim":66.0, - "partner":"3vq1" + "partner":"3vq2" }, { "sim":65.0, @@ -106719,64 +106937,64 @@ "leucine rich repeat (lrr) protein" ], "keywords":[ - "power", - "general", - "control", - "combining", - "designs", - "junction", + "curvature", + "designed", + "surface", + "finally", + "component", "molecular", - "proteins", - "greatly", "complementarity", - "unique", - "approach", - "generate", - "appropriately", - "modules", - "scaffolds", - "reagents", + "recognition", + "junction", "polymerized", - "adjust", - "shape", - "designed", - "finally", - "apply", - "would", - "generated", - "different", "interest", + "creation", + "therapeutics", + "structures", + "first", + "different", + "combining", + "important", + "apply", + "scaffolds", + "shape", + "new", + "precisely", + "target", "surfaces", + "reagents", + "control", + "protein", + "curvatures", "illustrate", - "shapes", - "recognition", - "precisely", - "crystal", + "controlling", + "approach", + "blocks", + "proteins", + "would", + "binding", + "modules", + "greatly", "connect", "ability", - "target", - "set", + "general", + "shapes", + "adjust", "scaffold", + "building", "match", - "blocks", - "controlling", - "creation", - "therapeutics", - "protein", - "structures", - "surface", - "describe", + "generated", "constant", - "curvature", - "component", - "building", - "first", + "power", + "appropriately", + "crystal", + "describe", + "unique", "second", - "curvatures", - "binding", + "designs", "facilitate", - "important", - "new" + "generate", + "set" ], "release_date":"2015-01-07", "publication":"\"Control of repeat-protein curvature by computational protein design\", Nat.Struct.Mol.Biol., 22, 167-174", @@ -106977,10 +107195,6 @@ "sim":139.0, "partner":"2omx" }, - { - "sim":139.0, - "partner":"1o6t" - }, { "sim":139.0, "partner":"1o6v" @@ -106993,6 +107207,10 @@ "sim":139.0, "partner":"1o6s" }, + { + "sim":139.0, + "partner":"1o6t" + }, { "sim":138.0, "partner":"2omt" @@ -107061,6 +107279,14 @@ "sim":117.0, "partner":"8wvy" }, + { + "sim":117.0, + "partner":"8xt9" + }, + { + "sim":117.0, + "partner":"8xum" + }, { "sim":116.0, "partner":"4qxe" @@ -107169,10 +107395,6 @@ "sim":94.0, "partner":"1xku" }, - { - "sim":94.0, - "partner":"3w3j" - }, { "sim":94.0, "partner":"3w3k" @@ -107205,6 +107427,10 @@ "sim":94.0, "partner":"3w3g" }, + { + "sim":94.0, + "partner":"3w3j" + }, { "sim":93.0, "partner":"2r9u" @@ -107219,11 +107445,11 @@ }, { "sim":93.0, - "partner":"8wee" + "partner":"8web" }, { "sim":93.0, - "partner":"8web" + "partner":"8wee" }, { "sim":92.0, @@ -107257,10 +107483,6 @@ "sim":90.0, "partner":"1sq0" }, - { - "sim":90.0, - "partner":"3pmh" - }, { "sim":90.0, "partner":"1p9a" @@ -107273,6 +107495,10 @@ "sim":90.0, "partner":"1ook" }, + { + "sim":90.0, + "partner":"3pmh" + }, { "sim":90.0, "partner":"4c2b" @@ -107355,11 +107581,11 @@ }, { "sim":84.0, - "partner":"3ul7" + "partner":"3ul9" }, { "sim":84.0, - "partner":"3ul9" + "partner":"3ul7" }, { "sim":84.0, @@ -107407,15 +107633,15 @@ }, { "sim":77.0, - "partner":"8wo1" + "partner":"3fxi" }, { "sim":77.0, - "partner":"3fxi" + "partner":"8wta" }, { "sim":77.0, - "partner":"8wta" + "partner":"8wo1" }, { "sim":77.0, @@ -107621,68 +107847,68 @@ ], "subtitle":"Crystal structure of computational designed protein dlrr_i", "tags":[ - "leucine rich motifs", - "de novo protein" + "de novo protein", + "leucine rich motifs" ], "keywords":[ - "power", - "general", - "control", - "combining", - "designs", - "junction", + "curvature", + "designed", + "surface", + "finally", + "component", "molecular", - "proteins", - "greatly", "complementarity", - "unique", - "approach", - "generate", - "appropriately", - "modules", - "scaffolds", - "reagents", + "recognition", + "junction", "polymerized", - "adjust", - "shape", - "designed", - "finally", - "apply", - "would", - "generated", - "different", "interest", + "creation", + "therapeutics", + "structures", + "first", + "different", + "combining", + "important", + "apply", + "scaffolds", + "shape", + "new", + "precisely", + "target", "surfaces", + "reagents", + "control", + "protein", + "curvatures", "illustrate", - "shapes", - "recognition", - "precisely", - "crystal", + "controlling", + "approach", + "blocks", + "proteins", + "would", + "binding", + "modules", + "greatly", "connect", "ability", - "target", - "set", + "general", + "shapes", + "adjust", "scaffold", + "building", "match", - "blocks", - "controlling", - "creation", - "therapeutics", - "protein", - "structures", - "surface", - "describe", + "generated", "constant", - "curvature", - "component", - "building", - "first", + "power", + "appropriately", + "crystal", + "describe", + "unique", "second", - "curvatures", - "binding", + "designs", "facilitate", - "important", - "new" + "generate", + "set" ], "release_date":"2015-01-07", "publication":"\"Control of repeat-protein curvature by computational protein design\", Nat.Struct.Mol.Biol., 22, 167-174", @@ -107859,10 +108085,6 @@ "sim":150.0, "partner":"2omu" }, - { - "sim":148.0, - "partner":"1o6t" - }, { "sim":148.0, "partner":"1o6v" @@ -107875,6 +108097,10 @@ "sim":148.0, "partner":"1o6s" }, + { + "sim":148.0, + "partner":"1o6t" + }, { "sim":142.0, "partner":"4fmz" @@ -107915,6 +108141,14 @@ "sim":113.0, "partner":"8wvy" }, + { + "sim":113.0, + "partner":"8xt9" + }, + { + "sim":113.0, + "partner":"8xum" + }, { "sim":111.0, "partner":"2o6q" @@ -107939,10 +108173,6 @@ "sim":104.0, "partner":"3m19" }, - { - "sim":103.0, - "partner":"3w3j" - }, { "sim":103.0, "partner":"3w3k" @@ -107975,6 +108205,10 @@ "sim":103.0, "partner":"3w3g" }, + { + "sim":103.0, + "partner":"3w3j" + }, { "sim":102.0, "partner":"1h6u" @@ -108081,11 +108315,11 @@ }, { "sim":83.0, - "partner":"3ul7" + "partner":"3ul9" }, { "sim":83.0, - "partner":"3ul9" + "partner":"3ul7" }, { "sim":83.0, @@ -108113,11 +108347,11 @@ }, { "sim":81.0, - "partner":"8wee" + "partner":"8web" }, { "sim":81.0, - "partner":"8web" + "partner":"8wee" }, { "sim":80.0, @@ -108227,10 +108461,6 @@ "sim":67.0, "partner":"1gwb" }, - { - "sim":67.0, - "partner":"3pmh" - }, { "sim":67.0, "partner":"1p9a" @@ -108243,6 +108473,10 @@ "sim":67.0, "partner":"1ook" }, + { + "sim":67.0, + "partner":"3pmh" + }, { "sim":66.0, "partner":"3twi" @@ -108337,23 +108571,23 @@ }, { "sim":59.0, - "partner":"8wry" + "partner":"8wqt" }, { "sim":59.0, - "partner":"8wsa" + "partner":"8wry" }, { "sim":59.0, - "partner":"8wqt" + "partner":"8wsa" }, { "sim":59.0, - "partner":"3vq2" + "partner":"3vq1" }, { "sim":59.0, - "partner":"3vq1" + "partner":"3vq2" }, { "sim":58.0, @@ -108443,68 +108677,68 @@ ], "subtitle":"Crystal structure of computational designed leucine rich repeats dlrr_k in space group p22121", "tags":[ - "leucine rich motifs", - "de novo protein" + "de novo protein", + "leucine rich motifs" ], "keywords":[ - "power", - "general", - "control", - "combining", - "designs", - "junction", + "curvature", + "designed", + "surface", + "finally", + "component", "molecular", - "proteins", - "greatly", "complementarity", - "unique", - "approach", - "generate", - "appropriately", - "modules", - "scaffolds", - "reagents", + "recognition", + "junction", "polymerized", - "adjust", - "shape", - "designed", - "finally", - "apply", - "would", - "generated", - "different", "interest", + "creation", + "therapeutics", + "structures", + "first", + "different", + "combining", + "important", + "apply", + "scaffolds", + "shape", + "new", + "precisely", + "target", "surfaces", + "reagents", + "control", + "protein", + "curvatures", "illustrate", - "shapes", - "recognition", - "precisely", - "crystal", + "controlling", + "approach", + "blocks", + "proteins", + "would", + "binding", + "modules", + "greatly", "connect", "ability", - "target", - "set", + "general", + "shapes", + "adjust", "scaffold", + "building", "match", - "blocks", - "controlling", - "creation", - "therapeutics", - "protein", - "structures", - "surface", - "describe", + "generated", "constant", - "curvature", - "component", - "building", - "first", + "power", + "appropriately", + "crystal", + "describe", + "unique", "second", - "curvatures", - "binding", + "designs", "facilitate", - "important", - "new" + "generate", + "set" ], "release_date":"2015-01-07", "publication":"\"Control of repeat-protein curvature by computational protein design\", Nat.Struct.Mol.Biol., 22, 167-174", @@ -108673,10 +108907,6 @@ "sim":162.0, "partner":"2omu" }, - { - "sim":159.0, - "partner":"1o6t" - }, { "sim":159.0, "partner":"1o6v" @@ -108689,6 +108919,10 @@ "sim":159.0, "partner":"1o6s" }, + { + "sim":159.0, + "partner":"1o6t" + }, { "sim":151.0, "partner":"2o6q" @@ -108781,6 +109015,14 @@ "sim":127.0, "partner":"8wvy" }, + { + "sim":127.0, + "partner":"8xt9" + }, + { + "sim":127.0, + "partner":"8xum" + }, { "sim":126.0, "partner":"4qxe" @@ -108873,17 +109115,13 @@ "sim":102.0, "partner":"8wed" }, - { - "sim":102.0, - "partner":"8wee" - }, { "sim":102.0, "partner":"8web" }, { "sim":102.0, - "partner":"3w3j" + "partner":"8wee" }, { "sim":102.0, @@ -108917,6 +109155,10 @@ "sim":102.0, "partner":"3w3g" }, + { + "sim":102.0, + "partner":"3w3j" + }, { "sim":101.0, "partner":"8wef" @@ -109023,11 +109265,11 @@ }, { "sim":91.0, - "partner":"3ul7" + "partner":"3ul9" }, { "sim":91.0, - "partner":"3ul9" + "partner":"3ul7" }, { "sim":91.0, @@ -109073,10 +109315,6 @@ "sim":88.0, "partner":"1sq0" }, - { - "sim":88.0, - "partner":"3pmh" - }, { "sim":88.0, "partner":"1p9a" @@ -109089,6 +109327,10 @@ "sim":88.0, "partner":"1ook" }, + { + "sim":88.0, + "partner":"3pmh" + }, { "sim":88.0, "partner":"1g9u" @@ -109175,23 +109417,23 @@ }, { "sim":76.0, - "partner":"8wry" + "partner":"8wqt" }, { "sim":76.0, - "partner":"8wsa" + "partner":"8wry" }, { "sim":76.0, - "partner":"8wqt" + "partner":"8wsa" }, { "sim":76.0, - "partner":"3vq2" + "partner":"3vq1" }, { "sim":76.0, - "partner":"3vq1" + "partner":"3vq2" }, { "sim":75.0, @@ -109345,64 +109587,64 @@ "leucine rich repeats" ], "keywords":[ - "power", - "general", - "control", - "combining", - "designs", - "junction", + "curvature", + "designed", + "surface", + "finally", + "component", "molecular", - "proteins", - "greatly", "complementarity", - "unique", - "approach", - "generate", - "appropriately", - "modules", - "scaffolds", - "reagents", + "recognition", + "junction", "polymerized", - "adjust", - "shape", - "designed", - "finally", - "apply", - "would", - "generated", - "different", "interest", + "creation", + "therapeutics", + "structures", + "first", + "different", + "combining", + "important", + "apply", + "scaffolds", + "shape", + "new", + "precisely", + "target", "surfaces", + "reagents", + "control", + "protein", + "curvatures", "illustrate", - "shapes", - "recognition", - "precisely", - "crystal", + "controlling", + "approach", + "blocks", + "proteins", + "would", + "binding", + "modules", + "greatly", "connect", "ability", - "target", - "set", + "general", + "shapes", + "adjust", "scaffold", + "building", "match", - "blocks", - "controlling", - "creation", - "therapeutics", - "protein", - "structures", - "surface", - "describe", + "generated", "constant", - "curvature", - "component", - "building", - "first", + "power", + "appropriately", + "crystal", + "describe", + "unique", "second", - "curvatures", - "binding", + "designs", "facilitate", - "important", - "new" + "generate", + "set" ], "release_date":"2015-01-07", "publication":"\"Control of repeat-protein curvature by computational protein design\", Nat.Struct.Mol.Biol., 22, 167-174", @@ -109583,10 +109825,6 @@ "sim":128.0, "partner":"2o6q" }, - { - "sim":128.0, - "partner":"1o6t" - }, { "sim":128.0, "partner":"1o6v" @@ -109599,6 +109837,10 @@ "sim":128.0, "partner":"1o6s" }, + { + "sim":128.0, + "partner":"1o6t" + }, { "sim":117.0, "partner":"4fmz" @@ -109671,6 +109913,14 @@ "sim":99.0, "partner":"8wvy" }, + { + "sim":99.0, + "partner":"8xt9" + }, + { + "sim":99.0, + "partner":"8xum" + }, { "sim":97.0, "partner":"3zyj" @@ -109723,10 +109973,6 @@ "sim":83.0, "partner":"4oqt" }, - { - "sim":82.0, - "partner":"3w3j" - }, { "sim":82.0, "partner":"3w3k" @@ -109759,6 +110005,10 @@ "sim":82.0, "partner":"3w3g" }, + { + "sim":82.0, + "partner":"3w3j" + }, { "sim":81.0, "partner":"2z66" @@ -109887,10 +110137,6 @@ "sim":70.0, "partner":"1sq0" }, - { - "sim":70.0, - "partner":"3pmh" - }, { "sim":70.0, "partner":"1p9a" @@ -109903,6 +110149,10 @@ "sim":70.0, "partner":"1ook" }, + { + "sim":70.0, + "partner":"3pmh" + }, { "sim":70.0, "partner":"4c2b" @@ -109957,11 +110207,11 @@ }, { "sim":67.0, - "partner":"8wee" + "partner":"8web" }, { "sim":67.0, - "partner":"8web" + "partner":"8wee" }, { "sim":64.0, @@ -110033,23 +110283,23 @@ }, { "sim":59.0, - "partner":"8wry" + "partner":"8wqt" }, { "sim":59.0, - "partner":"8wsa" + "partner":"8wry" }, { "sim":59.0, - "partner":"8wqt" + "partner":"8wsa" }, { "sim":59.0, - "partner":"3vq2" + "partner":"3vq1" }, { "sim":59.0, - "partner":"3vq1" + "partner":"3vq2" }, { "sim":57.0, @@ -110147,14 +110397,14 @@ "subtitle":"Crystal structure of a de novo designed beta sheet protein, cystatin fold, northeast structural genomics consortium (nesg) target or486", "tags":[ "denovo beta sheet design", - "structural genomics", - "protein structure initiative", - "cystatin fold", "de novo protein", - "protein engineering", - "psi-biology", "target or486", - "northeast structural genomics consortium (nesg)" + "psi-biology", + "protein engineering", + "structural genomics", + "northeast structural genomics consortium (nesg)", + "cystatin fold", + "protein structure initiative" ], "keywords":[ "description", @@ -110247,12 +110497,12 @@ ], "subtitle":"Crystal structure of a de novo designed ferredoxin fold, northeast structural genomics consortium (nesg) target or461", "tags":[ + "de novo protein", "northeast structural genomics consortium (nesg) target or461", "ferredoxin fold", + "psi-biology", "structural genomics", - "protein structure initiative", - "de novo protein", - "psi-biology" + "protein structure initiative" ], "keywords":[ "description", @@ -110429,14 +110679,14 @@ ], "subtitle":"Crystal structure of engineered protein. northeast structural genomics consortium (nesg) target or497", "tags":[ - "or497", - "northeast structural genomics consortium", - "structural genomics", - "protein structure initiative", - "de novo protein", + "engineered protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", "psi-biology", - "engineered protein" + "or497", + "structural genomics", + "protein structure initiative" ], "keywords":[ "description", @@ -110517,10 +110767,6 @@ "sim":182.0, "partner":"1y2a" }, - { - "sim":182.0, - "partner":"3zir" - }, { "sim":182.0, "partner":"2ynr" @@ -110542,8 +110788,8 @@ "partner":"3ziq" }, { - "sim":181.0, - "partner":"3q5u" + "sim":182.0, + "partner":"3zir" }, { "sim":181.0, @@ -110551,11 +110797,11 @@ }, { "sim":181.0, - "partner":"1ejl" + "partner":"3knd" }, { "sim":181.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":181.0, @@ -110563,11 +110809,11 @@ }, { "sim":181.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":181.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":181.0, @@ -110575,15 +110821,15 @@ }, { "sim":181.0, - "partner":"1q1s" + "partner":"3q5u" }, { "sim":181.0, - "partner":"1q1t" + "partner":"1q1s" }, { "sim":181.0, - "partner":"4htv" + "partner":"1q1t" }, { "sim":181.0, @@ -110593,6 +110839,10 @@ "sim":181.0, "partner":"4mz6" }, + { + "sim":181.0, + "partner":"4htv" + }, { "sim":181.0, "partner":"3ukw" @@ -110623,19 +110873,19 @@ }, { "sim":180.0, - "partner":"3rzx" + "partner":"3rz9" }, { "sim":180.0, - "partner":"3oqs" + "partner":"3uvu" }, { "sim":180.0, - "partner":"3rz9" + "partner":"3rzx" }, { "sim":180.0, - "partner":"3uvu" + "partner":"3oqs" }, { "sim":170.0, @@ -110745,14 +110995,14 @@ ], "subtitle":"Crystal structure of engineered protein. northeast structural genomics consortium (nesg) target or366", "tags":[ - "northeast structural genomics consortium", - "or366", - "structural genomics", - "protein structure initiative", - "de novo protein", + "engineered protein", "nesg", + "de novo protein", + "northeast structural genomics consortium", "psi-biology", - "engineered protein" + "structural genomics", + "or366", + "protein structure initiative" ], "keywords":[ "description", @@ -110835,11 +111085,11 @@ }, { "sim":125.0, - "partner":"1bk5" + "partner":"3tpm" }, { "sim":125.0, - "partner":"3tpm" + "partner":"1bk5" }, { "sim":125.0, @@ -110869,10 +111119,6 @@ "sim":125.0, "partner":"1ial" }, - { - "sim":125.0, - "partner":"3zir" - }, { "sim":125.0, "partner":"2ynr" @@ -110893,6 +111139,10 @@ "sim":125.0, "partner":"3ziq" }, + { + "sim":125.0, + "partner":"3zir" + }, { "sim":125.0, "partner":"1wa5" @@ -110903,11 +111153,11 @@ }, { "sim":124.0, - "partner":"3q5u" + "partner":"4oih" }, { "sim":124.0, - "partner":"4oih" + "partner":"3knd" }, { "sim":124.0, @@ -110915,11 +111165,11 @@ }, { "sim":124.0, - "partner":"3knd" + "partner":"1ejy" }, { "sim":124.0, - "partner":"1ejy" + "partner":"1pjm" }, { "sim":124.0, @@ -110927,11 +111177,11 @@ }, { "sim":124.0, - "partner":"1pjm" + "partner":"1pjn" }, { "sim":124.0, - "partner":"1pjn" + "partner":"3q5u" }, { "sim":124.0, @@ -110945,10 +111195,6 @@ "sim":124.0, "partner":"4ba3" }, - { - "sim":124.0, - "partner":"4htv" - }, { "sim":124.0, "partner":"4mz5" @@ -110959,11 +111205,7 @@ }, { "sim":124.0, - "partner":"3rzx" - }, - { - "sim":124.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":124.0, @@ -110997,6 +111239,14 @@ "sim":124.0, "partner":"3uvu" }, + { + "sim":124.0, + "partner":"3rzx" + }, + { + "sim":124.0, + "partner":"3oqs" + }, { "sim":122.0, "partner":"3tpo" @@ -111097,65 +111347,65 @@ ], "subtitle":"Computationally designed three helix bundle", "tags":[ - "de novo protein", - "helical bundle" + "helical bundle", + "de novo protein" ], "keywords":[ - "coiled", - "per", - "monomeric", - "pentameric", - "proteins", - "connected", - "models", - "helices", - "enables", - "combinatorial", - "approach", - "close", - "stable", - "mole", - "wide", - "calculations", - "identify", - "crick", "designed", - "equations", "geometries", - "custom", - "parallel", + "alternative", + "designing", + "enables", + "calculations", "antiparallel", - "crystal", - "arrangements", - "extrapolated", - "extremely", - "bundle", - "procedure", - "produced", + "models", "design", "sequences", - "60", - "core", - "structures", + "backbones", + "custom", "kilocalories", - "applications", - "identical", - "supercoil", - "designing", - "helix", - "describe", - "\u03b4gfold", - "parameters", "hyperstable", - "varying", + "extrapolated", "untwisted", - "building", + "loop", "nearly", - "backbones", - "alternative", + "equations", + "structures", + "crick", + "core", + "monomeric", + "helix", + "parameters", + "connected", + "pentameric", + "supercoil", + "extremely", + "wide", + "approach", + "proteins", + "mole", "packing", - "loop", - "range" + "produced", + "varying", + "coiled", + "identify", + "close", + "combinatorial", + "parallel", + "building", + "60", + "identical", + "procedure", + "applications", + "crystal", + "stable", + "describe", + "arrangements", + "helices", + "\u03b4gfold", + "range", + "bundle", + "per" ], "release_date":"2014-10-15", "publication":"\"High thermodynamic stability of parametrically designed helical bundles\", Science, 346, 481-485", @@ -111252,90 +111502,90 @@ ], "subtitle":"Structure of a prion peptide", "tags":[ - "membrane protein, de novo protein", "de novo protein", "membrane protein", - "prion peptide" + "prion peptide", + "membrane protein, de novo protein" ], "keywords":[ - "containing", - "indicating", - "constructs", - "studies", - "129", - "studied", - "phenotype", + "disease", + "probe", + "resolution", "intermolecular", - "possibilities", - "\u03b21", - "comprehensive", - "influences", - "peptide", - "polymorphic", - "prion", - "11", - "contains", + "differences", + "residue", + "protein", + "polymorphism", + "vary", + "continuous", + "site", + "rigorous", "crystal", - "determined", - "propagation", - "enriched", - "initiation", - "probe", "conformation", - "c", - "disease", - "pathogenesis", - "influenced", - "suggesting", - "\u00e5", - "conversion", - "yielded", + "conformational", + "formed", + "\u03b21", "influence", - "vary", - "nature", - "surveying", - "sheets", + "effect", + "influences", + "residues", + "comprehensive", + "studied", "lengths", - "structures", - "construct", - "revealed", - "form", - "pathogenic", - "contribute", - "investigate", - "strand", - "associated", - "reveals", + "approach", + "129", + "several", + "may", + "contains", + "possibilities", + "suggesting", + "ensemble", "extent", - "ranging", - "resolution", - "continuous", + "construct", "four", - "may", + "susceptibility", + "peptide", + "11", + "investigate", + "c", + "normal", "12", - "several", - "polymorphism", "design", - "predominantly", - "effect", - "ensemble", + "prion", + "possible", + "polymorphic", + "different", + "surveying", + "indicating", + "propagation", + "pathogenic", + "sheets", "prp", - "susceptibility", - "rigorous", - "conformational", - "approach", + "phenotype", + "reveals", "peptides", - "different", - "residues", - "normal", - "protein", - "residue", - "differences", + "predominantly", + "associated", + "enriched", + "form", + "revealed", + "influenced", + "structures", + "constructs", + "ranging", + "contribute", + "\u00e5", + "determined", + "nature", "diseases", - "possible", - "site", + "yielded", + "initiation", + "strand", "sc", - "formed" + "studies", + "containing", + "pathogenesis", + "conversion" ], "release_date":"2015-05-27", "publication":"\"Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations\", Biochemistry, 54, 3640-3648", @@ -111449,116 +111699,116 @@ ], "subtitle":"Crystal structure of fn3con", "tags":[ - "fn3", "fibronectin type iii", + "protein stability", "de novo protein", "consensus design", - "protein stability" + "fn3" ], "keywords":[ - "domain", - "unfolding", - "bridge", - "studies", - "use", - "improvement", - "homologous", - "enhance", - "alignment", - "stabilities", - "determine", - "crystal", - "determined", - "potential", - "features", + "molecular", + "rate", + "optimized", + "hydrophobic", "show", - "sequences", - "robustness", - "basis", - "interactions", - "enhanced", - "structure", - "networks", - "unfavorable", - "power", - "availability", - "employed", - "greatly", - "\u00e5", - "electrostatic", "number", - "resulting", - "networked", - "highly", - "improving", - "removal", - "dynamics", - "structures", - "mol", - "kcal", - "likely", + "single", + "core", + "via", + "bridge", + "protein", + "study", + "improvement", + "increased", "significantly", - "compared", - "cooperatively", - "consensus", - "rapid", - "stability", "salt", - "fn3", - "data", + "rapid", + "unfolding", + "together", + "networks", + "removal", + "domains", + "demonstrate", + "power", + "fn3con", + "crystal", + "using", + "stabilities", + "simulations", + "knowledge", "taken", - "molecular", - "reveals", + "mechanisms", + "enhance", + "govern", + "due", + "unfavorable", + "technique", + "basis", + "stability", "large", - "via", - "temperature", - "reliable", - "increased", - "method", - "iii", - "simulations", - "rate", - "result", "several", - "comparison", + "use", + "consensus", + "iii", + "highly", + "\u03b4g", + "unprecedented", + "networked", + "robustness", + "features", + "combination", + "increase", + "relies", "design", - "type", - "melting", + "enhanced", + "compared", + "electrostatic", + "fn3", + "reliable", + "possible", + "2123", + "domain", + "kcal", + "potential", + "enhancing", + "era", + "mol", "reduced", - "core", - "govern", - "cooperative", - "using", - "rather", - "\u03b4g", - "hydrophobic", - "technique", + "type", + "varying", "underlying", "sequence", - "increase", - "2123", - "relies", - "demonstrate", - "fn3con", - "optimized", + "reveals", + "determine", + "mechanism", + "method", + "cooperative", + "dynamics", + "reveal", "rising", - "study", - "single", - "unprecedented", + "employed", + "homologous", + "sequences", + "cooperatively", + "rather", + "structures", + "improving", + "\u00e5", + "likely", + "structure", + "availability", + "determined", + "resulting", + "temperature", + "interactions", "fibronectin", - "together", - "reveal", - "due", - "enhancing", - "domains", - "mechanism", - "protein", - "mechanisms", - "knowledge", - "varying", - "combination", - "possible", - "era" + "melting", + "greatly", + "result", + "studies", + "data", + "alignment", + "comparison" ], "release_date":"2015-02-11", "publication":"\"Structural and dynamic properties that govern the stability of an engineered fibronectin type III domain\", Protein Eng.Des.Sel., 28, 67-78", @@ -111996,88 +112246,88 @@ "tags":[ "membrane protein", "de novo protein", - "de novo protein, membrane protein", - "prion peptide" + "prion peptide", + "de novo protein, membrane protein" ], "keywords":[ - "containing", - "indicating", - "constructs", - "studies", - "129", - "studied", - "phenotype", + "disease", + "probe", + "resolution", "intermolecular", - "possibilities", - "\u03b21", - "comprehensive", - "influences", - "peptide", - "polymorphic", - "prion", - "11", - "contains", + "differences", + "residue", + "protein", + "polymorphism", + "vary", + "continuous", + "site", + "rigorous", "crystal", - "determined", - "propagation", - "enriched", - "initiation", - "probe", "conformation", - "c", - "disease", - "pathogenesis", - "influenced", - "suggesting", - "\u00e5", - "conversion", - "yielded", + "conformational", + "formed", + "\u03b21", "influence", - "vary", - "nature", - "surveying", - "sheets", + "effect", + "influences", + "residues", + "comprehensive", + "studied", "lengths", - "structures", - "construct", - "revealed", - "form", - "pathogenic", - "contribute", - "investigate", - "strand", - "associated", - "reveals", + "approach", + "129", + "several", + "may", + "contains", + "possibilities", + "suggesting", + "ensemble", "extent", - "ranging", - "resolution", - "continuous", + "construct", "four", - "may", + "susceptibility", + "peptide", + "11", + "investigate", + "c", + "normal", "12", - "several", - "polymorphism", "design", - "predominantly", - "effect", - "ensemble", + "prion", + "possible", + "polymorphic", + "different", + "surveying", + "indicating", + "propagation", + "pathogenic", + "sheets", "prp", - "susceptibility", - "rigorous", - "conformational", - "approach", + "phenotype", + "reveals", "peptides", - "different", - "residues", - "normal", - "protein", - "residue", - "differences", + "predominantly", + "associated", + "enriched", + "form", + "revealed", + "influenced", + "structures", + "constructs", + "ranging", + "contribute", + "\u00e5", + "determined", + "nature", "diseases", - "possible", - "site", + "yielded", + "initiation", + "strand", "sc", - "formed" + "studies", + "containing", + "pathogenesis", + "conversion" ], "release_date":"2015-05-27", "publication":"\"Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations\", Biochemistry, 54, 3640-3648", @@ -112173,88 +112423,88 @@ "tags":[ "membrane protein", "de novo protein", - "de novo protein, membrane protein", - "prion peptide" + "prion peptide", + "de novo protein, membrane protein" ], "keywords":[ - "containing", - "indicating", - "constructs", - "studies", - "129", - "studied", - "phenotype", + "disease", + "probe", + "resolution", "intermolecular", - "possibilities", - "\u03b21", - "comprehensive", - "influences", - "peptide", - "polymorphic", - "prion", - "11", - "contains", + "differences", + "residue", + "protein", + "polymorphism", + "vary", + "continuous", + "site", + "rigorous", "crystal", - "determined", - "propagation", - "enriched", - "initiation", - "probe", "conformation", - "c", - "disease", - "pathogenesis", - "influenced", - "suggesting", - "\u00e5", - "conversion", - "yielded", + "conformational", + "formed", + "\u03b21", "influence", - "vary", - "nature", - "surveying", - "sheets", + "effect", + "influences", + "residues", + "comprehensive", + "studied", "lengths", - "structures", - "construct", - "revealed", - "form", - "pathogenic", - "contribute", - "investigate", - "strand", - "associated", - "reveals", + "approach", + "129", + "several", + "may", + "contains", + "possibilities", + "suggesting", + "ensemble", "extent", - "ranging", - "resolution", - "continuous", + "construct", "four", - "may", + "susceptibility", + "peptide", + "11", + "investigate", + "c", + "normal", "12", - "several", - "polymorphism", "design", - "predominantly", - "effect", - "ensemble", + "prion", + "possible", + "polymorphic", + "different", + "surveying", + "indicating", + "propagation", + "pathogenic", + "sheets", "prp", - "susceptibility", - "rigorous", - "conformational", - "approach", + "phenotype", + "reveals", "peptides", - "different", - "residues", - "normal", - "protein", - "residue", - "differences", + "predominantly", + "associated", + "enriched", + "form", + "revealed", + "influenced", + "structures", + "constructs", + "ranging", + "contribute", + "\u00e5", + "determined", + "nature", "diseases", - "possible", - "site", + "yielded", + "initiation", + "strand", "sc", - "formed" + "studies", + "containing", + "pathogenesis", + "conversion" ], "release_date":"2015-05-27", "publication":"\"Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations\", Biochemistry, 54, 3640-3648", @@ -112378,65 +112628,65 @@ "subtitle":"Thermodynamic hyperstability in parametrically designed helical bundles", "tags":[ "de novo protein", - "thermodynamic hyperstability helical bundle", - "protein design" + "protein design", + "thermodynamic hyperstability helical bundle" ], "keywords":[ - "coiled", - "per", - "monomeric", - "pentameric", - "proteins", - "connected", - "models", - "helices", - "enables", - "combinatorial", - "approach", - "close", - "stable", - "mole", - "wide", - "calculations", - "identify", - "crick", "designed", - "equations", "geometries", - "custom", - "parallel", + "alternative", + "designing", + "enables", + "calculations", "antiparallel", - "crystal", - "arrangements", - "extrapolated", - "extremely", - "bundle", - "procedure", - "produced", + "models", "design", "sequences", - "60", - "core", - "structures", + "backbones", + "custom", "kilocalories", - "applications", - "identical", - "supercoil", - "designing", - "helix", - "describe", - "\u03b4gfold", - "parameters", "hyperstable", - "varying", + "extrapolated", "untwisted", - "building", + "loop", "nearly", - "backbones", - "alternative", + "equations", + "structures", + "crick", + "core", + "monomeric", + "helix", + "parameters", + "connected", + "pentameric", + "supercoil", + "extremely", + "wide", + "approach", + "proteins", + "mole", "packing", - "loop", - "range" + "produced", + "varying", + "coiled", + "identify", + "close", + "combinatorial", + "parallel", + "building", + "60", + "identical", + "procedure", + "applications", + "crystal", + "stable", + "describe", + "arrangements", + "helices", + "\u03b4gfold", + "range", + "bundle", + "per" ], "release_date":"2014-11-05", "publication":"\"High Thermodynamic Stability of Parametrically Designed Helical Bundles\", Science, 346, 481", @@ -112562,65 +112812,65 @@ "subtitle":"Thermodynamic hyperstability in parametrically designed helical bundles", "tags":[ "de novo protein", - "thermodynamic hyperstability helical bundle", - "protein design" + "protein design", + "thermodynamic hyperstability helical bundle" ], "keywords":[ - "coiled", - "per", - "monomeric", - "pentameric", - "proteins", - "connected", - "models", - "helices", - "enables", - "combinatorial", - "approach", - "close", - "stable", - "mole", - "wide", - "calculations", - "identify", - "crick", "designed", - "equations", "geometries", - "custom", - "parallel", + "alternative", + "designing", + "enables", + "calculations", "antiparallel", - "crystal", - "arrangements", - "extrapolated", - "extremely", - "bundle", - "procedure", - "produced", + "models", "design", "sequences", - "60", - "core", - "structures", + "backbones", + "custom", "kilocalories", - "applications", - "identical", - "supercoil", - "designing", - "helix", - "describe", - "\u03b4gfold", - "parameters", "hyperstable", - "varying", + "extrapolated", "untwisted", - "building", + "loop", "nearly", - "backbones", - "alternative", + "equations", + "structures", + "crick", + "core", + "monomeric", + "helix", + "parameters", + "connected", + "pentameric", + "supercoil", + "extremely", + "wide", + "approach", + "proteins", + "mole", "packing", - "loop", - "range" + "produced", + "varying", + "coiled", + "identify", + "close", + "combinatorial", + "parallel", + "building", + "60", + "identical", + "procedure", + "applications", + "crystal", + "stable", + "describe", + "arrangements", + "helices", + "\u03b4gfold", + "range", + "bundle", + "per" ], "release_date":"2014-11-05", "publication":"\"High Thermodynamic Stability of Parametrically Designed Helical Bundles\", Science, 346, 481", @@ -112739,83 +112989,83 @@ "subtitle":"Designed armadillo repeat protein with 5 internal repeats, 2nd generation c-cap and 3rd generation n-cap", "tags":[ "armadillo repeat", - "rotein engineering", "de novo protein", + "rotein engineering", "repeat protein" ], "keywords":[ - "stability", - "hence", - "designs", - "expected", - "arrangement", - "constructs", - "part", - "proteins", - "reveals", - "forms", - "thereby", - "serves", - "exactly", - "m1", - "similar", - "putative", - "improves", + "designed", + "repeats", + "impairs", + "order", + "design", + "indeed", + "yiiim5aii", + "development", "resolution", - "modules", - "four", - "\u00e5", - "m4", - "considerations", + "compared", + "repeat", + "serves", "variants", - "indeed", - "impairs", - "designed", - "modular", + "structural", "m5", - "residues", - "useful", + "structures", + "constructs", "movement", + "putative", + "hence", + "improves", + "armadillo", + "differences", + "three", + "\u00e5", + "unfortunately", "m3", - "system", - "crystal", - "site", + "residues", + "thereby", "determined", - "extremely", - "scaffold", - "comparison", - "design", - "order", - "unfortunately", - "structures", "protein", - "regular", "buried", - "improvements", - "full", - "identical", - "development", - "differences", - "future", - "three", - "yiiim5aii", - "repeat", - "armadillo", - "repeats", - "sequence", - "caused", - "contacting", - "effects", - "compared", - "molecules", - "conformations", + "useful", + "extremely", + "stability", + "modules", + "develop", + "proteins", + "part", "internal", - "structural", + "molecules", + "regular", "packing", + "considerations", "consensus", + "modular", + "m4", + "site", + "improvements", + "contacting", + "scaffold", + "sequence", + "system", "intrinsic", - "five", - "develop" + "reveals", + "arrangement", + "forms", + "expected", + "identical", + "conformations", + "m1", + "crystal", + "caused", + "four", + "full", + "designs", + "effects", + "future", + "similar", + "exactly", + "comparison", + "five" ], "release_date":"2016-01-13", "publication":"\"Structures of Designed Armadillo-Repeat Proteins Show Propagation of Inter-Repeat Interface Effects\", Acta Crystallogr.,Sect.D, 72, 168", @@ -112856,11 +113106,11 @@ }, { "sim":514.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":514.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":514.0, @@ -112872,11 +113122,11 @@ }, { "sim":514.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":514.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":492.0, @@ -112948,11 +113198,11 @@ }, { "sim":296.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":296.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":284.0, @@ -113014,15 +113264,15 @@ }, { "sim":187.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":187.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":187.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":187.0, @@ -113092,10 +113342,6 @@ "sim":177.0, "partner":"4u54" }, - { - "sim":177.0, - "partner":"4u5o" - }, { "sim":177.0, "partner":"3ve6" @@ -113126,15 +113372,15 @@ }, { "sim":177.0, - "partner":"3l3q" + "partner":"4u5o" }, { "sim":177.0, - "partner":"3btr" + "partner":"3l3q" }, { "sim":177.0, - "partner":"1y2a" + "partner":"3btr" }, { "sim":177.0, @@ -113142,11 +113388,11 @@ }, { "sim":177.0, - "partner":"1ial" + "partner":"1y2a" }, { "sim":177.0, - "partner":"3q5u" + "partner":"1ial" }, { "sim":177.0, @@ -113154,15 +113400,15 @@ }, { "sim":177.0, - "partner":"1ejl" + "partner":"4yi0" }, { "sim":177.0, - "partner":"4yi0" + "partner":"3knd" }, { "sim":177.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":177.0, @@ -113170,11 +113416,11 @@ }, { "sim":177.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":177.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":177.0, @@ -113182,7 +113428,7 @@ }, { "sim":177.0, - "partner":"3zir" + "partner":"3q5u" }, { "sim":177.0, @@ -113204,6 +113450,10 @@ "sim":177.0, "partner":"3ziq" }, + { + "sim":177.0, + "partner":"3zir" + }, { "sim":177.0, "partner":"4uaf" @@ -113236,10 +113486,6 @@ "sim":177.0, "partner":"4ba3" }, - { - "sim":177.0, - "partner":"4htv" - }, { "sim":177.0, "partner":"4mz5" @@ -113250,15 +113496,7 @@ }, { "sim":177.0, - "partner":"3rzx" - }, - { - "sim":177.0, - "partner":"5e6q" - }, - { - "sim":177.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":177.0, @@ -113292,6 +113530,18 @@ "sim":177.0, "partner":"3uvu" }, + { + "sim":177.0, + "partner":"3rzx" + }, + { + "sim":177.0, + "partner":"5e6q" + }, + { + "sim":177.0, + "partner":"3oqs" + }, { "sim":175.0, "partner":"4b18" @@ -113406,84 +113656,84 @@ ], "subtitle":"Designed armadillo repeat protein with 4 internal repeats, 2nd generation c-cap and 3rd generation n-cap", "tags":[ - "protein engineering", "armadillo repeat", "de novo protein", - "repeat protein" + "repeat protein", + "protein engineering" ], "keywords":[ - "stability", - "hence", - "designs", - "expected", - "arrangement", - "constructs", - "part", - "proteins", - "reveals", - "forms", - "thereby", - "serves", - "exactly", - "m1", - "similar", - "putative", - "improves", + "designed", + "repeats", + "impairs", + "order", + "design", + "indeed", + "yiiim5aii", + "development", "resolution", - "modules", - "four", - "\u00e5", - "m4", - "considerations", + "compared", + "repeat", + "serves", "variants", - "indeed", - "impairs", - "designed", - "modular", + "structural", "m5", - "residues", - "useful", + "structures", + "constructs", "movement", + "putative", + "hence", + "improves", + "armadillo", + "differences", + "three", + "\u00e5", + "unfortunately", "m3", - "system", - "crystal", - "site", + "residues", + "thereby", "determined", - "extremely", - "scaffold", - "comparison", - "design", - "order", - "unfortunately", - "structures", "protein", - "regular", "buried", - "improvements", - "full", - "identical", - "development", - "differences", - "future", - "three", - "yiiim5aii", - "repeat", - "armadillo", - "repeats", - "sequence", - "caused", - "contacting", - "effects", - "compared", - "molecules", - "conformations", + "useful", + "extremely", + "stability", + "modules", + "develop", + "proteins", + "part", "internal", - "structural", + "molecules", + "regular", "packing", + "considerations", "consensus", + "modular", + "m4", + "site", + "improvements", + "contacting", + "scaffold", + "sequence", + "system", "intrinsic", - "five", - "develop" + "reveals", + "arrangement", + "forms", + "expected", + "identical", + "conformations", + "m1", + "crystal", + "caused", + "four", + "full", + "designs", + "effects", + "future", + "similar", + "exactly", + "comparison", + "five" ], "release_date":"2016-01-13", "publication":"\"Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects\", Acta Crystallogr D Struct Biol, 72, 168-175", @@ -113532,11 +113782,11 @@ }, { "sim":410.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":410.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":410.0, @@ -113548,11 +113798,11 @@ }, { "sim":410.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":410.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":409.0, @@ -113624,11 +113874,11 @@ }, { "sim":295.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":295.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":267.0, @@ -113694,15 +113944,15 @@ }, { "sim":165.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":165.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":165.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":165.0, @@ -113722,15 +113972,15 @@ }, { "sim":163.0, - "partner":"4pvz" + "partner":"1bk5" }, { "sim":163.0, - "partner":"1bk5" + "partner":"1bk6" }, { "sim":163.0, - "partner":"1bk6" + "partner":"4pvz" }, { "sim":163.0, @@ -113768,10 +114018,6 @@ "sim":157.0, "partner":"4u54" }, - { - "sim":157.0, - "partner":"4u5o" - }, { "sim":157.0, "partner":"3ve6" @@ -113802,15 +114048,15 @@ }, { "sim":157.0, - "partner":"3l3q" + "partner":"4u5o" }, { "sim":157.0, - "partner":"3btr" + "partner":"3l3q" }, { "sim":157.0, - "partner":"1y2a" + "partner":"3btr" }, { "sim":157.0, @@ -113818,11 +114064,11 @@ }, { "sim":157.0, - "partner":"1ial" + "partner":"1y2a" }, { "sim":157.0, - "partner":"3zir" + "partner":"1ial" }, { "sim":157.0, @@ -113845,8 +114091,8 @@ "partner":"3ziq" }, { - "sim":156.0, - "partner":"3q5u" + "sim":157.0, + "partner":"3zir" }, { "sim":156.0, @@ -113854,15 +114100,15 @@ }, { "sim":156.0, - "partner":"1ejl" + "partner":"4yi0" }, { "sim":156.0, - "partner":"4yi0" + "partner":"3knd" }, { "sim":156.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":156.0, @@ -113870,16 +114116,20 @@ }, { "sim":156.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":156.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":156.0, "partner":"1pjn" }, + { + "sim":156.0, + "partner":"3q5u" + }, { "sim":156.0, "partner":"4uaf" @@ -113896,10 +114146,6 @@ "sim":156.0, "partner":"4ba3" }, - { - "sim":156.0, - "partner":"4htv" - }, { "sim":156.0, "partner":"4mz5" @@ -113910,15 +114156,7 @@ }, { "sim":156.0, - "partner":"3rzx" - }, - { - "sim":156.0, - "partner":"5e6q" - }, - { - "sim":156.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":156.0, @@ -113952,6 +114190,18 @@ "sim":156.0, "partner":"3uvu" }, + { + "sim":156.0, + "partner":"3rzx" + }, + { + "sim":156.0, + "partner":"5e6q" + }, + { + "sim":156.0, + "partner":"3oqs" + }, { "sim":155.0, "partner":"4uae" @@ -114055,83 +114305,83 @@ ], "subtitle":"Designed armadillo repeat protein with 5 internal repeats, 2nd generation c-cap and 3rd generation n-cap", "tags":[ - "protein engineering", "de novo protein", - "repeat protein" + "repeat protein", + "protein engineering" ], "keywords":[ - "stability", - "hence", - "designs", - "expected", - "arrangement", - "constructs", - "part", - "proteins", - "reveals", - "forms", - "thereby", - "serves", - "exactly", - "m1", - "similar", - "putative", - "improves", + "designed", + "repeats", + "impairs", + "order", + "design", + "indeed", + "yiiim5aii", + "development", "resolution", - "modules", - "four", - "\u00e5", - "m4", - "considerations", + "compared", + "repeat", + "serves", "variants", - "indeed", - "impairs", - "designed", - "modular", + "structural", "m5", - "residues", - "useful", + "structures", + "constructs", "movement", + "putative", + "hence", + "improves", + "armadillo", + "differences", + "three", + "\u00e5", + "unfortunately", "m3", - "system", - "crystal", - "site", + "residues", + "thereby", "determined", - "extremely", - "scaffold", - "comparison", - "design", - "order", - "unfortunately", - "structures", "protein", - "regular", "buried", - "improvements", - "full", - "identical", - "development", - "differences", - "future", - "three", - "yiiim5aii", - "repeat", - "armadillo", - "repeats", - "sequence", - "caused", - "contacting", - "effects", - "compared", - "molecules", - "conformations", + "useful", + "extremely", + "stability", + "modules", + "develop", + "proteins", + "part", "internal", - "structural", + "molecules", + "regular", "packing", + "considerations", "consensus", + "modular", + "m4", + "site", + "improvements", + "contacting", + "scaffold", + "sequence", + "system", "intrinsic", - "five", - "develop" + "reveals", + "arrangement", + "forms", + "expected", + "identical", + "conformations", + "m1", + "crystal", + "caused", + "four", + "full", + "designs", + "effects", + "future", + "similar", + "exactly", + "comparison", + "five" ], "release_date":"2016-01-13", "publication":"\"Structures of Designed Armadillo-Repeat Proteins Show Propagation of Inter-Repeat Interface Effects\", Acta Crystallogr.,Sect.D, 72, 168", @@ -114172,11 +114422,11 @@ }, { "sim":512.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":512.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":512.0, @@ -114188,11 +114438,11 @@ }, { "sim":512.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":512.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":491.0, @@ -114264,11 +114514,11 @@ }, { "sim":291.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":291.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":282.0, @@ -114346,15 +114596,15 @@ }, { "sim":187.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":187.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":187.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":187.0, @@ -114412,10 +114662,6 @@ "sim":174.0, "partner":"4u54" }, - { - "sim":174.0, - "partner":"4u5o" - }, { "sim":174.0, "partner":"3ve6" @@ -114444,6 +114690,10 @@ "sim":174.0, "partner":"4u5n" }, + { + "sim":174.0, + "partner":"4u5o" + }, { "sim":174.0, "partner":"3l3q" @@ -114454,11 +114704,11 @@ }, { "sim":174.0, - "partner":"1y2a" + "partner":"4zdu" }, { "sim":174.0, - "partner":"4zdu" + "partner":"1y2a" }, { "sim":174.0, @@ -114476,25 +114726,21 @@ "sim":174.0, "partner":"1ial" }, - { - "sim":174.0, - "partner":"3q5u" - }, { "sim":174.0, "partner":"4oih" }, { "sim":174.0, - "partner":"1ejl" + "partner":"4yi0" }, { "sim":174.0, - "partner":"4yi0" + "partner":"3knd" }, { "sim":174.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":174.0, @@ -114502,11 +114748,11 @@ }, { "sim":174.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":174.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":174.0, @@ -114514,7 +114760,7 @@ }, { "sim":174.0, - "partner":"3zir" + "partner":"3q5u" }, { "sim":174.0, @@ -114536,6 +114782,10 @@ "sim":174.0, "partner":"3ziq" }, + { + "sim":174.0, + "partner":"3zir" + }, { "sim":174.0, "partner":"4uaf" @@ -114568,10 +114818,6 @@ "sim":174.0, "partner":"4ba3" }, - { - "sim":174.0, - "partner":"4htv" - }, { "sim":174.0, "partner":"4mz5" @@ -114582,15 +114828,7 @@ }, { "sim":174.0, - "partner":"3rzx" - }, - { - "sim":174.0, - "partner":"5e6q" - }, - { - "sim":174.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":174.0, @@ -114624,6 +114862,18 @@ "sim":174.0, "partner":"3uvu" }, + { + "sim":174.0, + "partner":"3rzx" + }, + { + "sim":174.0, + "partner":"5e6q" + }, + { + "sim":174.0, + "partner":"3oqs" + }, { "sim":171.0, "partner":"3tpo" @@ -114728,88 +114978,88 @@ "tags":[ "membrane protein", "de novo protein", - "de novo protein, membrane protein", - "prion peptide" + "prion peptide", + "de novo protein, membrane protein" ], "keywords":[ - "containing", - "indicating", - "constructs", - "studies", - "129", - "studied", - "phenotype", + "disease", + "probe", + "resolution", "intermolecular", - "possibilities", - "\u03b21", - "comprehensive", - "influences", - "peptide", - "polymorphic", - "prion", - "11", - "contains", + "differences", + "residue", + "protein", + "polymorphism", + "vary", + "continuous", + "site", + "rigorous", "crystal", - "determined", - "propagation", - "enriched", - "initiation", - "probe", "conformation", - "c", - "disease", - "pathogenesis", - "influenced", - "suggesting", - "\u00e5", - "conversion", - "yielded", + "conformational", + "formed", + "\u03b21", "influence", - "vary", - "nature", - "surveying", - "sheets", + "effect", + "influences", + "residues", + "comprehensive", + "studied", "lengths", - "structures", - "construct", - "revealed", - "form", - "pathogenic", - "contribute", - "investigate", - "strand", - "associated", - "reveals", + "approach", + "129", + "several", + "may", + "contains", + "possibilities", + "suggesting", + "ensemble", "extent", - "ranging", - "resolution", - "continuous", + "construct", "four", - "may", + "susceptibility", + "peptide", + "11", + "investigate", + "c", + "normal", "12", - "several", - "polymorphism", "design", - "predominantly", - "effect", - "ensemble", + "prion", + "possible", + "polymorphic", + "different", + "surveying", + "indicating", + "propagation", + "pathogenic", + "sheets", "prp", - "susceptibility", - "rigorous", - "conformational", - "approach", + "phenotype", + "reveals", "peptides", - "different", - "residues", - "normal", - "protein", - "residue", - "differences", + "predominantly", + "associated", + "enriched", + "form", + "revealed", + "influenced", + "structures", + "constructs", + "ranging", + "contribute", + "\u00e5", + "determined", + "nature", "diseases", - "possible", - "site", + "yielded", + "initiation", + "strand", "sc", - "formed" + "studies", + "containing", + "pathogenesis", + "conversion" ], "release_date":"2015-05-27", "publication":"\"Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations\", Biochemistry, 54, 3640-3648", @@ -114905,88 +115155,88 @@ "tags":[ "membrane protein", "de novo protein", - "de novo protein, membrane protein", - "prion peptide" + "prion peptide", + "de novo protein, membrane protein" ], "keywords":[ - "containing", - "indicating", - "constructs", - "studies", - "129", - "studied", - "phenotype", + "disease", + "probe", + "resolution", "intermolecular", - "possibilities", - "\u03b21", - "comprehensive", - "influences", - "peptide", - "polymorphic", - "prion", - "11", - "contains", + "differences", + "residue", + "protein", + "polymorphism", + "vary", + "continuous", + "site", + "rigorous", "crystal", - "determined", - "propagation", - "enriched", - "initiation", - "probe", "conformation", - "c", - "disease", - "pathogenesis", - "influenced", - "suggesting", - "\u00e5", - "conversion", - "yielded", + "conformational", + "formed", + "\u03b21", "influence", - "vary", - "nature", - "surveying", - "sheets", + "effect", + "influences", + "residues", + "comprehensive", + "studied", "lengths", - "structures", - "construct", - "revealed", - "form", - "pathogenic", - "contribute", - "investigate", - "strand", - "associated", - "reveals", + "approach", + "129", + "several", + "may", + "contains", + "possibilities", + "suggesting", + "ensemble", "extent", - "ranging", - "resolution", - "continuous", + "construct", "four", - "may", + "susceptibility", + "peptide", + "11", + "investigate", + "c", + "normal", "12", - "several", - "polymorphism", "design", - "predominantly", - "effect", - "ensemble", + "prion", + "possible", + "polymorphic", + "different", + "surveying", + "indicating", + "propagation", + "pathogenic", + "sheets", "prp", - "susceptibility", - "rigorous", - "conformational", - "approach", + "phenotype", + "reveals", "peptides", - "different", - "residues", - "normal", - "protein", - "residue", - "differences", + "predominantly", + "associated", + "enriched", + "form", + "revealed", + "influenced", + "structures", + "constructs", + "ranging", + "contribute", + "\u00e5", + "determined", + "nature", "diseases", - "possible", - "site", + "yielded", + "initiation", + "strand", "sc", - "formed" + "studies", + "containing", + "pathogenesis", + "conversion" ], "release_date":"2015-05-27", "publication":"\"Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations\", Biochemistry, 54, 3640-3648", @@ -115082,88 +115332,88 @@ "tags":[ "membrane protein", "de novo protein", - "de novo protein, membrane protein", - "prion peptide" + "prion peptide", + "de novo protein, membrane protein" ], "keywords":[ - "containing", - "indicating", - "constructs", - "studies", - "129", - "studied", - "phenotype", + "disease", + "probe", + "resolution", "intermolecular", - "possibilities", - "\u03b21", - "comprehensive", - "influences", - "peptide", - "polymorphic", - "prion", - "11", - "contains", + "differences", + "residue", + "protein", + "polymorphism", + "vary", + "continuous", + "site", + "rigorous", "crystal", - "determined", - "propagation", - "enriched", - "initiation", - "probe", "conformation", - "c", - "disease", - "pathogenesis", - "influenced", - "suggesting", - "\u00e5", - "conversion", - "yielded", + "conformational", + "formed", + "\u03b21", "influence", - "vary", - "nature", - "surveying", - "sheets", + "effect", + "influences", + "residues", + "comprehensive", + "studied", "lengths", - "structures", - "construct", - "revealed", - "form", - "pathogenic", - "contribute", - "investigate", - "strand", - "associated", - "reveals", + "approach", + "129", + "several", + "may", + "contains", + "possibilities", + "suggesting", + "ensemble", "extent", - "ranging", - "resolution", - "continuous", + "construct", "four", - "may", + "susceptibility", + "peptide", + "11", + "investigate", + "c", + "normal", "12", - "several", - "polymorphism", "design", - "predominantly", - "effect", - "ensemble", + "prion", + "possible", + "polymorphic", + "different", + "surveying", + "indicating", + "propagation", + "pathogenic", + "sheets", "prp", - "susceptibility", - "rigorous", - "conformational", - "approach", + "phenotype", + "reveals", "peptides", - "different", - "residues", - "normal", - "protein", - "residue", - "differences", + "predominantly", + "associated", + "enriched", + "form", + "revealed", + "influenced", + "structures", + "constructs", + "ranging", + "contribute", + "\u00e5", + "determined", + "nature", "diseases", - "possible", - "site", + "yielded", + "initiation", + "strand", "sc", - "formed" + "studies", + "containing", + "pathogenesis", + "conversion" ], "release_date":"2015-05-27", "publication":"\"Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations\", Biochemistry, 54, 3640-3648", @@ -115257,90 +115507,90 @@ ], "subtitle":"Crystal structure of prp pepttide", "tags":[ - "membrane protein", "de novo protein", - "de novo protein, membrane protein", - "prion peptide" + "membrane protein", + "prion peptide", + "de novo protein, membrane protein" ], "keywords":[ - "containing", - "indicating", - "constructs", - "studies", - "129", - "studied", - "phenotype", + "disease", + "probe", + "resolution", "intermolecular", - "possibilities", - "\u03b21", - "comprehensive", - "influences", - "peptide", - "polymorphic", - "prion", - "11", - "contains", + "differences", + "residue", + "protein", + "polymorphism", + "vary", + "continuous", + "site", + "rigorous", "crystal", - "determined", - "propagation", - "enriched", - "initiation", - "probe", "conformation", - "c", - "disease", - "pathogenesis", - "influenced", - "suggesting", - "\u00e5", - "conversion", - "yielded", + "conformational", + "formed", + "\u03b21", "influence", - "vary", - "nature", - "surveying", - "sheets", + "effect", + "influences", + "residues", + "comprehensive", + "studied", "lengths", - "structures", - "construct", - "revealed", - "form", - "pathogenic", - "contribute", - "investigate", - "strand", - "associated", - "reveals", + "approach", + "129", + "several", + "may", + "contains", + "possibilities", + "suggesting", + "ensemble", "extent", - "ranging", - "resolution", - "continuous", + "construct", "four", - "may", + "susceptibility", + "peptide", + "11", + "investigate", + "c", + "normal", "12", - "several", - "polymorphism", "design", - "predominantly", - "effect", - "ensemble", + "prion", + "possible", + "polymorphic", + "different", + "surveying", + "indicating", + "propagation", + "pathogenic", + "sheets", "prp", - "susceptibility", - "rigorous", - "conformational", - "approach", + "phenotype", + "reveals", "peptides", - "different", - "residues", - "normal", - "protein", - "residue", - "differences", + "predominantly", + "associated", + "enriched", + "form", + "revealed", + "influenced", + "structures", + "constructs", + "ranging", + "contribute", + "\u00e5", + "determined", + "nature", "diseases", - "possible", - "site", + "yielded", + "initiation", + "strand", "sc", - "formed" + "studies", + "containing", + "pathogenesis", + "conversion" ], "release_date":"2015-05-27", "publication":"\"Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations\", Biochemistry, 54, 3640-3648", @@ -115436,88 +115686,88 @@ "tags":[ "membrane protein", "de novo protein", - "de novo protein, membrane protein", - "prion peptide" + "prion peptide", + "de novo protein, membrane protein" ], "keywords":[ - "containing", - "indicating", - "constructs", - "studies", - "129", - "studied", - "phenotype", + "disease", + "probe", + "resolution", "intermolecular", - "possibilities", - "\u03b21", - "comprehensive", - "influences", - "peptide", - "polymorphic", - "prion", - "11", - "contains", + "differences", + "residue", + "protein", + "polymorphism", + "vary", + "continuous", + "site", + "rigorous", "crystal", - "determined", - "propagation", - "enriched", - "initiation", - "probe", "conformation", - "c", - "disease", - "pathogenesis", - "influenced", - "suggesting", - "\u00e5", - "conversion", - "yielded", + "conformational", + "formed", + "\u03b21", "influence", - "vary", - "nature", - "surveying", - "sheets", + "effect", + "influences", + "residues", + "comprehensive", + "studied", "lengths", - "structures", - "construct", - "revealed", - "form", - "pathogenic", - "contribute", - "investigate", - "strand", - "associated", - "reveals", + "approach", + "129", + "several", + "may", + "contains", + "possibilities", + "suggesting", + "ensemble", "extent", - "ranging", - "resolution", - "continuous", + "construct", "four", - "may", + "susceptibility", + "peptide", + "11", + "investigate", + "c", + "normal", "12", - "several", - "polymorphism", "design", - "predominantly", - "effect", - "ensemble", + "prion", + "possible", + "polymorphic", + "different", + "surveying", + "indicating", + "propagation", + "pathogenic", + "sheets", "prp", - "susceptibility", - "rigorous", - "conformational", - "approach", + "phenotype", + "reveals", "peptides", - "different", - "residues", - "normal", - "protein", - "residue", - "differences", + "predominantly", + "associated", + "enriched", + "form", + "revealed", + "influenced", + "structures", + "constructs", + "ranging", + "contribute", + "\u00e5", + "determined", + "nature", "diseases", - "possible", - "site", + "yielded", + "initiation", + "strand", "sc", - "formed" + "studies", + "containing", + "pathogenesis", + "conversion" ], "release_date":"2015-05-27", "publication":"\"Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations\", Biochemistry, 54, 3640-3648", @@ -115611,90 +115861,90 @@ ], "subtitle":"Crystal structure of a prion peptide", "tags":[ - "membrane protein", "de novo protein", - "de novo protein, membrane protein", - "prion peptide" + "membrane protein", + "prion peptide", + "de novo protein, membrane protein" ], "keywords":[ - "containing", - "indicating", - "constructs", - "studies", - "129", - "studied", - "phenotype", + "disease", + "probe", + "resolution", "intermolecular", - "possibilities", - "\u03b21", - "comprehensive", - "influences", - "peptide", - "polymorphic", - "prion", - "11", - "contains", + "differences", + "residue", + "protein", + "polymorphism", + "vary", + "continuous", + "site", + "rigorous", "crystal", - "determined", - "propagation", - "enriched", - "initiation", - "probe", "conformation", - "c", - "disease", - "pathogenesis", - "influenced", - "suggesting", - "\u00e5", - "conversion", - "yielded", + "conformational", + "formed", + "\u03b21", "influence", - "vary", - "nature", - "surveying", - "sheets", + "effect", + "influences", + "residues", + "comprehensive", + "studied", "lengths", - "structures", - "construct", - "revealed", - "form", - "pathogenic", - "contribute", - "investigate", - "strand", - "associated", - "reveals", + "approach", + "129", + "several", + "may", + "contains", + "possibilities", + "suggesting", + "ensemble", "extent", - "ranging", - "resolution", - "continuous", + "construct", "four", - "may", + "susceptibility", + "peptide", + "11", + "investigate", + "c", + "normal", "12", - "several", - "polymorphism", "design", - "predominantly", - "effect", - "ensemble", + "prion", + "possible", + "polymorphic", + "different", + "surveying", + "indicating", + "propagation", + "pathogenic", + "sheets", "prp", - "susceptibility", - "rigorous", - "conformational", - "approach", + "phenotype", + "reveals", "peptides", - "different", - "residues", - "normal", - "protein", - "residue", - "differences", + "predominantly", + "associated", + "enriched", + "form", + "revealed", + "influenced", + "structures", + "constructs", + "ranging", + "contribute", + "\u00e5", + "determined", + "nature", "diseases", - "possible", - "site", + "yielded", + "initiation", + "strand", "sc", - "formed" + "studies", + "containing", + "pathogenesis", + "conversion" ], "release_date":"2015-05-27", "publication":"\"Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations\", Biochemistry, 54, 3640-3648", @@ -115790,88 +116040,88 @@ "tags":[ "membrane protein", "de novo protein", - "de novo protein, membrane protein", - "prion peptide" + "prion peptide", + "de novo protein, membrane protein" ], "keywords":[ - "containing", - "indicating", - "constructs", - "studies", - "129", - "studied", - "phenotype", + "disease", + "probe", + "resolution", "intermolecular", - "possibilities", - "\u03b21", - "comprehensive", - "influences", - "peptide", - "polymorphic", - "prion", - "11", - "contains", + "differences", + "residue", + "protein", + "polymorphism", + "vary", + "continuous", + "site", + "rigorous", "crystal", - "determined", - "propagation", - "enriched", - "initiation", - "probe", "conformation", - "c", - "disease", - "pathogenesis", - "influenced", - "suggesting", - "\u00e5", - "conversion", - "yielded", + "conformational", + "formed", + "\u03b21", "influence", - "vary", - "nature", - "surveying", - "sheets", + "effect", + "influences", + "residues", + "comprehensive", + "studied", "lengths", - "structures", - "construct", - "revealed", - "form", - "pathogenic", - "contribute", - "investigate", - "strand", - "associated", - "reveals", + "approach", + "129", + "several", + "may", + "contains", + "possibilities", + "suggesting", + "ensemble", "extent", - "ranging", - "resolution", - "continuous", + "construct", "four", - "may", + "susceptibility", + "peptide", + "11", + "investigate", + "c", + "normal", "12", - "several", - "polymorphism", "design", - "predominantly", - "effect", - "ensemble", + "prion", + "possible", + "polymorphic", + "different", + "surveying", + "indicating", + "propagation", + "pathogenic", + "sheets", "prp", - "susceptibility", - "rigorous", - "conformational", - "approach", + "phenotype", + "reveals", "peptides", - "different", - "residues", - "normal", - "protein", - "residue", - "differences", + "predominantly", + "associated", + "enriched", + "form", + "revealed", + "influenced", + "structures", + "constructs", + "ranging", + "contribute", + "\u00e5", + "determined", + "nature", "diseases", - "possible", - "site", + "yielded", + "initiation", + "strand", "sc", - "formed" + "studies", + "containing", + "pathogenesis", + "conversion" ], "release_date":"2015-05-27", "publication":"\"Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations\", Biochemistry, 54, 3640-3648", @@ -115965,90 +116215,90 @@ ], "subtitle":"Crystal structure of a prion peptide", "tags":[ - "membrane protein", "de novo protein", - "de novo protein, membrane protein", - "prion peptide" + "membrane protein", + "prion peptide", + "de novo protein, membrane protein" ], "keywords":[ - "containing", - "indicating", - "constructs", - "studies", - "129", - "studied", - "phenotype", + "disease", + "probe", + "resolution", "intermolecular", - "possibilities", - "\u03b21", - "comprehensive", - "influences", - "peptide", - "polymorphic", - "prion", - "11", - "contains", + "differences", + "residue", + "protein", + "polymorphism", + "vary", + "continuous", + "site", + "rigorous", "crystal", - "determined", - "propagation", - "enriched", - "initiation", - "probe", "conformation", - "c", - "disease", - "pathogenesis", - "influenced", - "suggesting", - "\u00e5", - "conversion", - "yielded", + "conformational", + "formed", + "\u03b21", "influence", - "vary", - "nature", - "surveying", - "sheets", + "effect", + "influences", + "residues", + "comprehensive", + "studied", "lengths", - "structures", - "construct", - "revealed", - "form", - "pathogenic", - "contribute", - "investigate", - "strand", - "associated", - "reveals", + "approach", + "129", + "several", + "may", + "contains", + "possibilities", + "suggesting", + "ensemble", "extent", - "ranging", - "resolution", - "continuous", + "construct", "four", - "may", + "susceptibility", + "peptide", + "11", + "investigate", + "c", + "normal", "12", - "several", - "polymorphism", "design", - "predominantly", - "effect", - "ensemble", + "prion", + "possible", + "polymorphic", + "different", + "surveying", + "indicating", + "propagation", + "pathogenic", + "sheets", "prp", - "susceptibility", - "rigorous", - "conformational", - "approach", + "phenotype", + "reveals", "peptides", - "different", - "residues", - "normal", - "protein", - "residue", - "differences", + "predominantly", + "associated", + "enriched", + "form", + "revealed", + "influenced", + "structures", + "constructs", + "ranging", + "contribute", + "\u00e5", + "determined", + "nature", "diseases", - "possible", - "site", + "yielded", + "initiation", + "strand", "sc", - "formed" + "studies", + "containing", + "pathogenesis", + "conversion" ], "release_date":"2015-05-27", "publication":"\"Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations\", Biochemistry, 54, 3640-3648", @@ -116162,81 +116412,81 @@ ], "subtitle":"Crystal structure of designed cppr-polya protein", "tags":[ - "designer rna-binding proteins", - "pentatricopeptide repeat", "synthetic biology", - "rna-protein interactions", - "de novo protein" + "pentatricopeptide repeat", + "de novo protein", + "designer rna-binding proteins", + "rna-protein interactions" ], "keywords":[ - "predicted", - "stability", - "diverse", - "ppr", "elucidate", - "control", - "pentatricopeptide", - "great", - "importance", - "studies", - "proteins", - "restricted", - "gene", + "engineering", + "recognition", + "design", + "mechanisms", + "structural", + "insights", + "atomic", + "mechanistic", + "repeat", + "association", + "diverse", + "observed", + "structurally", + "structures", + "provides", + "suggests", + "natural", + "understand", "regulation", - "aspects", - "use", - "modes", "rna", - "strategy", - "although", - "tools", - "artificial", - "understand", - "modular", - "programmed", - "mode", + "modes", + "biological", + "gene", "residues", - "modelling", - "highly", + "eukaryotic", + "provided", + "great", + "although", + "new", + "strategy", "functions", - "robust", - "suggests", - "recognition", + "target", + "control", + "ppr", "nature", + "interactions", "inconsistencies", - "engineering", - "provides", - "target", - "domains", - "observed", - "holds", - "design", - "mechanistic", "basis", - "structures", - "interactions", - "promise", - "eukaryotic", - "mechanisms", - "natural", - "association", - "recent", - "atomic", - "structurally", - "repeat", - "biological", - "insights", "understanding", - "computational", + "stability", + "modelling", + "proteins", + "mode", + "binding", + "programmed", + "pentatricopeptide", "metabolism", + "artificial", + "use", + "consensus", + "modular", + "holds", "cells", - "binding", - "structural", + "insoluble", + "domains", + "predicted", + "highly", + "promise", + "aspects", + "studies", + "recent", "create", - "consensus", - "provided", - "new", - "insoluble" + "restricted", + "computational", + "importance", + "tools", + "robust" ], "release_date":"2014-12-24", "publication":"\"An artificial PPR scaffold for programmable RNA recognition\", Nat Commun, 5, 5729-5729", @@ -116376,81 +116626,81 @@ ], "subtitle":"Crystal structure of designed cppr-polyc protein", "tags":[ - "designer rna-binding proteins", - "pentatricopeptide repeat", "synthetic biology", - "rna-protein interactions", - "de novo protein" + "pentatricopeptide repeat", + "de novo protein", + "designer rna-binding proteins", + "rna-protein interactions" ], "keywords":[ - "predicted", - "stability", - "diverse", - "ppr", "elucidate", - "control", - "pentatricopeptide", - "great", - "importance", - "studies", - "proteins", - "restricted", - "gene", + "engineering", + "recognition", + "design", + "mechanisms", + "structural", + "insights", + "atomic", + "mechanistic", + "repeat", + "association", + "diverse", + "observed", + "structurally", + "structures", + "provides", + "suggests", + "natural", + "understand", "regulation", - "aspects", - "use", - "modes", "rna", - "strategy", - "although", - "tools", - "artificial", - "understand", - "modular", - "programmed", - "mode", + "modes", + "biological", + "gene", "residues", - "modelling", - "highly", + "eukaryotic", + "provided", + "great", + "although", + "new", + "strategy", "functions", - "robust", - "suggests", - "recognition", + "target", + "control", + "ppr", "nature", + "interactions", "inconsistencies", - "engineering", - "provides", - "target", - "domains", - "observed", - "holds", - "design", - "mechanistic", "basis", - "structures", - "interactions", - "promise", - "eukaryotic", - "mechanisms", - "natural", - "association", - "recent", - "atomic", - "structurally", - "repeat", - "biological", - "insights", "understanding", - "computational", + "stability", + "modelling", + "proteins", + "mode", + "binding", + "programmed", + "pentatricopeptide", "metabolism", + "artificial", + "use", + "consensus", + "modular", + "holds", "cells", - "binding", - "structural", + "insoluble", + "domains", + "predicted", + "highly", + "promise", + "aspects", + "studies", + "recent", "create", - "consensus", - "provided", - "new", - "insoluble" + "restricted", + "computational", + "importance", + "tools", + "robust" ], "release_date":"2014-12-24", "publication":"\"An artificial PPR scaffold for programmable RNA recognition\", Nat Commun, 5, 5729-5729", @@ -116590,96 +116840,96 @@ ], "subtitle":"Beta1 synthetic solenoid protein", "tags":[ - "scaffold", "solenoid", + "scaffold", "structural protein" ], "keywords":[ - "domain", - "matches", - "use", - "designed", - "goals", - "basic", - "repetitive", - "experimentally", - "crystal", - "target", - "based", - "synthetic", - "conformation", - "structure", - "repeat", - "computationally", - "however", - "nanotechnology", - "without", - "pentapeptide", - "incorrect", - "proteins", - "solved", - "de", - "family", - "variants", - "ability", - "chemically", - "better", - "simplifying", - "onto", - "structures", - "construct", - "atomic", - "intrinsically", - "loops", - "large", - "globular", "resolution", - "class", - "fragments", - "closely", - "shown", - "unit", - "design", - "core", - "unsolved", "key", + "repeat", "clearly", - "known", + "generalized", + "intrinsically", + "core", + "precision", "appeared", - "designs", - "one", - "approach", - "showing", - "also", + "unsolved", + "folding", + "goals", + "protein", + "globular", + "simplifying", "novo", - "insertions", - "length", + "domains", "inserting", + "two", "offer", + "crystal", "attractive", - "biologically", - "modular", - "generalized", + "conformation", + "however", + "computationally", + "experimentally", + "family", + "level", + "matches", + "nanotechnology", + "approach", + "showing", + "proteins", + "large", "constructed", - "precision", - "understood", - "extension", - "two", - "problem", + "use", + "modular", "scaffold", - "domains", - "synthesized", - "protein", - "backbone", - "projecting", - "hairpin", + "pentapeptide", + "construct", "computational", + "design", + "onto", + "atomic", + "length", "accommodate", - "folding", + "loops", + "incorrect", + "resolved", + "domain", + "also", + "projecting", + "chemically", + "shown", + "understood", + "backbone", + "ability", + "solved", + "insertions", "developed", + "designed", + "basic", + "one", "loop", - "level", - "resolved" + "variants", + "extension", + "structures", + "de", + "fragments", + "synthesized", + "based", + "hairpin", + "without", + "structure", + "synthetic", + "repetitive", + "closely", + "target", + "biologically", + "known", + "class", + "unit", + "problem", + "designs", + "better" ], "release_date":"2016-03-09", "publication":"\"Synthetic beta-solenoid proteins with the fragment-free computational design of a beta-hairpin extension\", Proc.Natl.Acad.Sci.USA, 113, 10346-10351", @@ -116712,11 +116962,11 @@ "seq_thr_sim_designed":[ { "sim":437.0, - "partner":"5dzb" + "partner":"4yfo" }, { "sim":437.0, - "partner":"4yfo" + "partner":"5dzb" }, { "sim":417.0, @@ -116810,27 +117060,27 @@ }, { "sim":57.0, - "partner":"4evc" + "partner":"3ta8" }, { "sim":57.0, - "partner":"4evd" + "partner":"3t9j" }, { "sim":57.0, - "partner":"4eve" + "partner":"4evb" }, { "sim":57.0, - "partner":"3ta8" + "partner":"4evc" }, { "sim":57.0, - "partner":"3t9j" + "partner":"4evd" }, { "sim":57.0, - "partner":"4evb" + "partner":"4eve" }, { "sim":57.0, @@ -116880,10 +117130,6 @@ "sim":55.0, "partner":"3nd1" }, - { - "sim":55.0, - "partner":"4d2w" - }, { "sim":55.0, "partner":"4d2p" @@ -116916,6 +117162,10 @@ "sim":55.0, "partner":"4d2v" }, + { + "sim":55.0, + "partner":"4d2w" + }, { "sim":55.0, "partner":"2rim" @@ -116936,10 +117186,6 @@ "sim":55.0, "partner":"3s7y" }, - { - "sim":54.0, - "partner":"3rg6" - }, { "sim":54.0, "partner":"2wvw" @@ -116952,6 +117198,10 @@ "sim":54.0, "partner":"2peo" }, + { + "sim":54.0, + "partner":"3rg6" + }, { "sim":54.0, "partner":"3ffl" @@ -117068,10 +117318,6 @@ "sim":53.0, "partner":"2ews" }, - { - "sim":53.0, - "partner":"4rtl" - }, { "sim":53.0, "partner":"4rtm" @@ -117114,7 +117360,7 @@ }, { "sim":53.0, - "partner":"3ws7" + "partner":"4rtl" }, { "sim":53.0, @@ -117126,11 +117372,7 @@ }, { "sim":53.0, - "partner":"4h2w" - }, - { - "sim":53.0, - "partner":"3mey" + "partner":"3ws7" }, { "sim":53.0, @@ -117168,6 +117410,14 @@ "sim":53.0, "partner":"4h2v" }, + { + "sim":53.0, + "partner":"4h2w" + }, + { + "sim":53.0, + "partner":"3mey" + }, { "sim":53.0, "partner":"1v33" @@ -117236,10 +117486,6 @@ "sim":52.0, "partner":"4p6c" }, - { - "sim":52.0, - "partner":"4yvk" - }, { "sim":52.0, "partner":"4yqd" @@ -117264,6 +117510,10 @@ "sim":52.0, "partner":"4yvj" }, + { + "sim":52.0, + "partner":"4yvk" + }, { "sim":52.0, "partner":"1uaj" @@ -117392,10 +117642,6 @@ "sim":52.0, "partner":"4buc" }, - { - "sim":52.0, - "partner":"2q5l" - }, { "sim":52.0, "partner":"2q5o" @@ -117412,6 +117658,10 @@ "sim":52.0, "partner":"2q5j" }, + { + "sim":52.0, + "partner":"2q5l" + }, { "sim":52.0, "partner":"4r7l" @@ -117484,10 +117734,6 @@ "sim":51.0, "partner":"4lfn" }, - { - "sim":51.0, - "partner":"2vbq" - }, { "sim":51.0, "partner":"1s3z" @@ -117500,6 +117746,10 @@ "sim":51.0, "partner":"1s60" }, + { + "sim":51.0, + "partner":"2vbq" + }, { "sim":51.0, "partner":"2znz" @@ -117560,10 +117810,6 @@ "sim":51.0, "partner":"3ofv" }, - { - "sim":51.0, - "partner":"5bnq" - }, { "sim":51.0, "partner":"3me2" @@ -117574,12 +117820,16 @@ }, { "sim":51.0, - "partner":"3oci" + "partner":"5bnq" }, { "sim":51.0, "partner":"3oc3" }, + { + "sim":51.0, + "partner":"3oci" + }, { "sim":51.0, "partner":"1upi" @@ -117618,11 +117868,11 @@ }, { "sim":51.0, - "partner":"3rpu" + "partner":"8tlb" }, { "sim":51.0, - "partner":"8tlb" + "partner":"3rpu" }, { "sim":51.0, @@ -117630,15 +117880,15 @@ }, { "sim":51.0, - "partner":"4be6" + "partner":"4bei" }, { "sim":51.0, - "partner":"4bei" + "partner":"4be5" }, { "sim":51.0, - "partner":"4be5" + "partner":"4be6" }, { "sim":51.0, @@ -117670,27 +117920,35 @@ }, { "sim":51.0, - "partner":"3et1" + "partner":"8rwr" }, { "sim":51.0, - "partner":"1z6k" + "partner":"8rws" }, { "sim":51.0, - "partner":"1xse" + "partner":"8rwo" }, { "sim":51.0, - "partner":"4jgt" + "partner":"8rwp" }, { "sim":51.0, - "partner":"3g3d" + "partner":"3et1" }, { "sim":51.0, - "partner":"5a7y" + "partner":"1z6k" + }, + { + "sim":51.0, + "partner":"1xse" + }, + { + "sim":51.0, + "partner":"4jgt" }, { "sim":51.0, @@ -117708,6 +117966,14 @@ "sim":51.0, "partner":"4hkp" }, + { + "sim":51.0, + "partner":"3g3d" + }, + { + "sim":51.0, + "partner":"5a7y" + }, { "sim":51.0, "partner":"4iwx" @@ -117750,39 +118016,39 @@ }, { "sim":51.0, - "partner":"3sie" + "partner":"4i9z" }, { "sim":51.0, - "partner":"4g2w" + "partner":"4ia0" }, { "sim":51.0, - "partner":"4g2y" + "partner":"4oew" }, { "sim":51.0, - "partner":"4i9z" + "partner":"4oex" }, { "sim":51.0, - "partner":"4ia0" + "partner":"3shy" }, { "sim":51.0, - "partner":"4oew" + "partner":"3shz" }, { "sim":51.0, - "partner":"4oex" + "partner":"3sie" }, { "sim":51.0, - "partner":"3shy" + "partner":"4g2w" }, { "sim":51.0, - "partner":"3shz" + "partner":"4g2y" }, { "sim":51.0, @@ -117812,10 +118078,6 @@ "sim":51.0, "partner":"3wxm" }, - { - "sim":51.0, - "partner":"3c1y" - }, { "sim":51.0, "partner":"3c1z" @@ -117840,6 +118102,10 @@ "sim":51.0, "partner":"4yxm" }, + { + "sim":51.0, + "partner":"3c1y" + }, { "sim":51.0, "partner":"2rjg" @@ -117888,10 +118154,6 @@ "sim":51.0, "partner":"3vvm" }, - { - "sim":51.0, - "partner":"2y6r" - }, { "sim":51.0, "partner":"4a99" @@ -117912,6 +118174,10 @@ "sim":51.0, "partner":"2y6q" }, + { + "sim":51.0, + "partner":"2y6r" + }, { "sim":51.0, "partner":"3k01" @@ -117960,10 +118226,6 @@ "sim":51.0, "partner":"4lf2" }, - { - "sim":51.0, - "partner":"4cdm" - }, { "sim":51.0, "partner":"4cdn" @@ -117976,6 +118238,10 @@ "sim":51.0, "partner":"2xrz" }, + { + "sim":51.0, + "partner":"4cdm" + }, { "sim":51.0, "partner":"3ug3" @@ -118004,10 +118270,6 @@ "sim":51.0, "partner":"3qfb" }, - { - "sim":51.0, - "partner":"2cj9" - }, { "sim":51.0, "partner":"2cja" @@ -118020,6 +118282,10 @@ "sim":51.0, "partner":"2cjb" }, + { + "sim":51.0, + "partner":"2cj9" + }, { "sim":51.0, "partner":"4s21" @@ -118078,11 +118344,11 @@ }, { "sim":50.0, - "partner":"3gz2" + "partner":"4oml" }, { "sim":50.0, - "partner":"4oml" + "partner":"3gz2" }, { "sim":50.0, @@ -118146,15 +118412,15 @@ }, { "sim":50.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":50.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":50.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":50.0, @@ -118202,11 +118468,11 @@ }, { "sim":50.0, - "partner":"2ela" + "partner":"2b6b" }, { "sim":50.0, - "partner":"2b6b" + "partner":"2ela" }, { "sim":50.0, @@ -118242,11 +118508,11 @@ }, { "sim":50.0, - "partner":"4kce" + "partner":"2h66" }, { "sim":50.0, - "partner":"2h66" + "partner":"4kce" }, { "sim":50.0, @@ -118262,11 +118528,11 @@ }, { "sim":50.0, - "partner":"4jr4" + "partner":"4jr6" }, { "sim":50.0, - "partner":"4jr6" + "partner":"4jr4" }, { "sim":50.0, @@ -118292,10 +118558,6 @@ "sim":50.0, "partner":"2fz4" }, - { - "sim":50.0, - "partner":"3la7" - }, { "sim":50.0, "partner":"3la2" @@ -118306,15 +118568,15 @@ }, { "sim":50.0, - "partner":"3r6s" + "partner":"3la7" }, { "sim":50.0, - "partner":"2rde" + "partner":"3r6s" }, { "sim":50.0, - "partner":"4da6" + "partner":"2rde" }, { "sim":50.0, @@ -118368,6 +118630,10 @@ "sim":50.0, "partner":"4d8v" }, + { + "sim":50.0, + "partner":"4da6" + }, { "sim":50.0, "partner":"2yfa" @@ -118390,15 +118656,15 @@ }, { "sim":50.0, - "partner":"1zw3" + "partner":"1zvz" }, { "sim":50.0, - "partner":"1zvz" + "partner":"1zw2" }, { "sim":50.0, - "partner":"1zw2" + "partner":"1zw3" }, { "sim":50.0, @@ -118412,10 +118678,6 @@ "sim":50.0, "partner":"2jfq" }, - { - "sim":50.0, - "partner":"4rdh" - }, { "sim":50.0, "partner":"4rdi" @@ -118440,6 +118702,10 @@ "sim":50.0, "partner":"5djj" }, + { + "sim":50.0, + "partner":"4rdh" + }, { "sim":50.0, "partner":"5djk" @@ -118458,11 +118724,11 @@ }, { "sim":50.0, - "partner":"3ta4" + "partner":"3t9w" }, { "sim":50.0, - "partner":"3t9w" + "partner":"3ta4" }, { "sim":50.0, @@ -118474,19 +118740,19 @@ }, { "sim":50.0, - "partner":"3nha" + "partner":"3nh6" }, { "sim":50.0, - "partner":"3nhb" + "partner":"3nh9" }, { "sim":50.0, - "partner":"3nh6" + "partner":"3nha" }, { "sim":50.0, - "partner":"3nh9" + "partner":"3nhb" }, { "sim":50.0, @@ -118494,31 +118760,31 @@ }, { "sim":50.0, - "partner":"3ggo" + "partner":"3ggp" }, { "sim":50.0, - "partner":"3ggp" + "partner":"3ggg" }, { "sim":50.0, - "partner":"3ggg" + "partner":"3ggo" }, { "sim":50.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":50.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":50.0, - "partner":"3tm8" + "partner":"3tmc" }, { "sim":50.0, - "partner":"3tmb" + "partner":"3tmd" }, { "sim":50.0, @@ -118530,15 +118796,15 @@ }, { "sim":50.0, - "partner":"2pzm" + "partner":"2pzk" }, { "sim":50.0, - "partner":"2pzk" + "partner":"2pzl" }, { "sim":50.0, - "partner":"2pzl" + "partner":"2pzm" }, { "sim":50.0, @@ -118656,10 +118922,6 @@ "sim":50.0, "partner":"3kzk" }, - { - "sim":50.0, - "partner":"4m1i" - }, { "sim":50.0, "partner":"4d8f" @@ -118672,6 +118934,10 @@ "sim":50.0, "partner":"4m1h" }, + { + "sim":50.0, + "partner":"4m1i" + }, { "sim":50.0, "partner":"2b61" @@ -118700,14 +118966,6 @@ "sim":50.0, "partner":"4ocv" }, - { - "sim":50.0, - "partner":"4q3r" - }, - { - "sim":50.0, - "partner":"4q42" - }, { "sim":50.0, "partner":"4q3s" @@ -118742,19 +119000,23 @@ }, { "sim":50.0, - "partner":"3o2t" + "partner":"4q3r" }, { "sim":50.0, - "partner":"3bu7" + "partner":"4q42" }, { "sim":50.0, - "partner":"2xyo" + "partner":"3o2t" }, { "sim":50.0, - "partner":"4hcl" + "partner":"3bu7" + }, + { + "sim":50.0, + "partner":"2xyo" }, { "sim":50.0, @@ -118768,6 +119030,10 @@ "sim":50.0, "partner":"3au7" }, + { + "sim":50.0, + "partner":"4hcl" + }, { "sim":50.0, "partner":"4r9v" @@ -118794,11 +119060,11 @@ }, { "sim":50.0, - "partner":"3wkr" + "partner":"3wks" }, { "sim":50.0, - "partner":"3wks" + "partner":"3wkr" }, { "sim":50.0, @@ -118806,15 +119072,15 @@ }, { "sim":50.0, - "partner":"4euh" + "partner":"4eue" }, { "sim":50.0, - "partner":"4eue" + "partner":"4euf" }, { "sim":50.0, - "partner":"4euf" + "partner":"4euh" }, { "sim":50.0, @@ -118832,17 +119098,13 @@ "sim":50.0, "partner":"2alm" }, - { - "sim":50.0, - "partner":"2yhg" - }, { "sim":50.0, "partner":"4doy" }, { "sim":50.0, - "partner":"3amu" + "partner":"2yhg" }, { "sim":50.0, @@ -118850,11 +119112,11 @@ }, { "sim":50.0, - "partner":"2yjn" + "partner":"3amu" }, { "sim":50.0, - "partner":"2r98" + "partner":"2yjn" }, { "sim":50.0, @@ -118876,6 +119138,10 @@ "sim":50.0, "partner":"4i49" }, + { + "sim":50.0, + "partner":"2r98" + }, { "sim":50.0, "partner":"3qfs" @@ -118940,10 +119206,6 @@ "sim":50.0, "partner":"4tmu" }, - { - "sim":50.0, - "partner":"2r0p" - }, { "sim":50.0, "partner":"2r0c" @@ -118966,19 +119228,19 @@ }, { "sim":50.0, - "partner":"2hiv" + "partner":"2r0p" }, { "sim":50.0, - "partner":"2hix" + "partner":"2hiv" }, { "sim":50.0, - "partner":"3fjo" + "partner":"2hix" }, { "sim":50.0, - "partner":"4gyk" + "partner":"3fjo" }, { "sim":50.0, @@ -118986,7 +119248,7 @@ }, { "sim":50.0, - "partner":"2fw3" + "partner":"4gyk" }, { "sim":50.0, @@ -119008,6 +119270,10 @@ "sim":50.0, "partner":"4eph" }, + { + "sim":50.0, + "partner":"2fw3" + }, { "sim":50.0, "partner":"2bpo" @@ -119079,7 +119345,7 @@ ], "seq_max_sim_designed":{ "sim":437.0, - "partner":"5dzb" + "partner":"4yfo" }, "seq_max_sim_natural":{ "sim":451.0, @@ -119179,19 +119445,19 @@ }, { "sim":284.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":284.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":284.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":284.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":284.0, @@ -119199,35 +119465,35 @@ }, { "sim":284.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":284.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":284.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":284.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":284.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":284.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":284.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":284.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":279.0, @@ -119235,11 +119501,11 @@ }, { "sim":278.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":278.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":278.0, @@ -119311,7 +119577,7 @@ }, { "sim":262.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":262.0, @@ -119319,7 +119585,7 @@ }, { "sim":262.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":259.0, @@ -119439,11 +119705,11 @@ }, { "sim":218.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":218.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":218.0, @@ -119467,11 +119733,11 @@ }, { "sim":196.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":196.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":196.0, @@ -119493,6 +119759,10 @@ "sim":183.0, "partner":"5kba" }, + { + "sim":182.0, + "partner":"9glq" + }, { "sim":182.0, "partner":"4hqd" @@ -119661,11 +119931,11 @@ }, { "sim":229.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":229.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":218.0, @@ -119797,15 +120067,15 @@ }, { "sim":107.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":107.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":107.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":106.0, @@ -119821,11 +120091,11 @@ }, { "sim":98.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":98.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":98.0, @@ -119909,15 +120179,15 @@ }, { "sim":87.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":87.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":87.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":87.0, @@ -120049,15 +120319,15 @@ }, { "sim":75.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":75.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":75.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":74.0, @@ -120065,11 +120335,11 @@ }, { "sim":71.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":71.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":71.0, @@ -120155,6 +120425,10 @@ "sim":53.0, "partner":"3j5q" }, + { + "sim":53.0, + "partner":"8ycp" + }, { "sim":52.0, "partner":"4ber" @@ -120461,95 +120735,95 @@ "subtitle":"Beta1_ex1", "tags":[ "solenoid", - "synthetic protein", - "de novo protein" + "de novo protein", + "synthetic protein" ], "keywords":[ - "domain", - "matches", - "use", - "designed", - "goals", - "basic", - "repetitive", - "experimentally", - "crystal", - "target", - "based", - "synthetic", - "conformation", - "structure", - "repeat", - "computationally", - "however", - "nanotechnology", - "without", - "pentapeptide", - "incorrect", - "proteins", - "solved", - "de", - "family", - "variants", - "ability", - "chemically", - "better", - "simplifying", - "onto", - "structures", - "construct", - "atomic", - "intrinsically", - "loops", - "large", - "globular", "resolution", - "class", - "fragments", - "closely", - "shown", - "unit", - "design", - "core", - "unsolved", "key", + "repeat", "clearly", - "known", + "generalized", + "intrinsically", + "core", + "precision", "appeared", - "designs", - "one", - "approach", - "showing", - "also", + "unsolved", + "folding", + "goals", + "protein", + "globular", + "simplifying", "novo", - "insertions", - "length", + "domains", "inserting", + "two", "offer", + "crystal", "attractive", - "biologically", - "modular", - "generalized", + "conformation", + "however", + "computationally", + "experimentally", + "family", + "level", + "matches", + "nanotechnology", + "approach", + "showing", + "proteins", + "large", "constructed", - "precision", - "understood", - "extension", - "two", - "problem", + "use", + "modular", "scaffold", - "domains", - "synthesized", - "protein", - "backbone", - "projecting", - "hairpin", + "pentapeptide", + "construct", "computational", + "design", + "onto", + "atomic", + "length", "accommodate", - "folding", + "loops", + "incorrect", + "resolved", + "domain", + "also", + "projecting", + "chemically", + "shown", + "understood", + "backbone", + "ability", + "solved", + "insertions", "developed", + "designed", + "basic", + "one", "loop", - "level", - "resolved" + "variants", + "extension", + "structures", + "de", + "fragments", + "synthesized", + "based", + "hairpin", + "without", + "structure", + "synthetic", + "repetitive", + "closely", + "target", + "biologically", + "known", + "class", + "unit", + "problem", + "designs", + "better" ], "release_date":"2016-03-16", "publication":"\"Synthetic beta-solenoid proteins with the fragment-free computational design of a beta-hairpin extension\", Proc.Natl.Acad.Sci.USA, 113, 10346-10351", @@ -120680,27 +120954,27 @@ }, { "sim":57.0, - "partner":"4evc" + "partner":"3ta8" }, { "sim":57.0, - "partner":"4evd" + "partner":"3t9j" }, { "sim":57.0, - "partner":"4eve" + "partner":"4evb" }, { "sim":57.0, - "partner":"3ta8" + "partner":"4evc" }, { "sim":57.0, - "partner":"3t9j" + "partner":"4evd" }, { "sim":57.0, - "partner":"4evb" + "partner":"4eve" }, { "sim":57.0, @@ -120770,10 +121044,6 @@ "sim":55.0, "partner":"3nd1" }, - { - "sim":55.0, - "partner":"4d2w" - }, { "sim":55.0, "partner":"4d2p" @@ -120808,11 +121078,11 @@ }, { "sim":55.0, - "partner":"2rim" + "partner":"4d2w" }, { - "sim":54.0, - "partner":"3rg6" + "sim":55.0, + "partner":"2rim" }, { "sim":54.0, @@ -120826,6 +121096,10 @@ "sim":54.0, "partner":"2peo" }, + { + "sim":54.0, + "partner":"3rg6" + }, { "sim":54.0, "partner":"3ffl" @@ -120942,10 +121216,6 @@ "sim":53.0, "partner":"2ews" }, - { - "sim":53.0, - "partner":"4rtl" - }, { "sim":53.0, "partner":"4rtm" @@ -120988,7 +121258,7 @@ }, { "sim":53.0, - "partner":"3ws7" + "partner":"4rtl" }, { "sim":53.0, @@ -121000,11 +121270,7 @@ }, { "sim":53.0, - "partner":"4h2w" - }, - { - "sim":53.0, - "partner":"3mey" + "partner":"3ws7" }, { "sim":53.0, @@ -121042,6 +121308,14 @@ "sim":53.0, "partner":"4h2v" }, + { + "sim":53.0, + "partner":"4h2w" + }, + { + "sim":53.0, + "partner":"3mey" + }, { "sim":53.0, "partner":"1v33" @@ -121110,10 +121384,6 @@ "sim":52.0, "partner":"4p6c" }, - { - "sim":52.0, - "partner":"4yvk" - }, { "sim":52.0, "partner":"4yqd" @@ -121138,6 +121408,10 @@ "sim":52.0, "partner":"4yvj" }, + { + "sim":52.0, + "partner":"4yvk" + }, { "sim":52.0, "partner":"1uaj" @@ -121258,10 +121532,6 @@ "sim":52.0, "partner":"4buc" }, - { - "sim":52.0, - "partner":"2q5l" - }, { "sim":52.0, "partner":"2q5o" @@ -121278,6 +121548,10 @@ "sim":52.0, "partner":"2q5j" }, + { + "sim":52.0, + "partner":"2q5l" + }, { "sim":52.0, "partner":"4r7l" @@ -121350,10 +121624,6 @@ "sim":51.0, "partner":"4lfn" }, - { - "sim":51.0, - "partner":"2vbq" - }, { "sim":51.0, "partner":"1s3z" @@ -121366,6 +121636,10 @@ "sim":51.0, "partner":"1s60" }, + { + "sim":51.0, + "partner":"2vbq" + }, { "sim":51.0, "partner":"2znz" @@ -121426,10 +121700,6 @@ "sim":51.0, "partner":"3ofv" }, - { - "sim":51.0, - "partner":"5bnq" - }, { "sim":51.0, "partner":"3me2" @@ -121440,12 +121710,16 @@ }, { "sim":51.0, - "partner":"3oci" + "partner":"5bnq" }, { "sim":51.0, "partner":"3oc3" }, + { + "sim":51.0, + "partner":"3oci" + }, { "sim":51.0, "partner":"1upi" @@ -121484,11 +121758,11 @@ }, { "sim":51.0, - "partner":"3rpu" + "partner":"8tlb" }, { "sim":51.0, - "partner":"8tlb" + "partner":"3rpu" }, { "sim":51.0, @@ -121496,15 +121770,15 @@ }, { "sim":51.0, - "partner":"4be6" + "partner":"4bei" }, { "sim":51.0, - "partner":"4bei" + "partner":"4be5" }, { "sim":51.0, - "partner":"4be5" + "partner":"4be6" }, { "sim":51.0, @@ -121534,6 +121808,22 @@ "sim":51.0, "partner":"8rwq" }, + { + "sim":51.0, + "partner":"8rwr" + }, + { + "sim":51.0, + "partner":"8rws" + }, + { + "sim":51.0, + "partner":"8rwo" + }, + { + "sim":51.0, + "partner":"8rwp" + }, { "sim":51.0, "partner":"3et1" @@ -121560,27 +121850,27 @@ }, { "sim":51.0, - "partner":"3g3d" + "partner":"3bvj" }, { "sim":51.0, - "partner":"5a7y" + "partner":"3mw7" }, { "sim":51.0, - "partner":"3bvj" + "partner":"4hib" }, { "sim":51.0, - "partner":"3mw7" + "partner":"4hkp" }, { "sim":51.0, - "partner":"4hib" + "partner":"3g3d" }, { "sim":51.0, - "partner":"4hkp" + "partner":"5a7y" }, { "sim":51.0, @@ -121624,39 +121914,39 @@ }, { "sim":51.0, - "partner":"3sie" + "partner":"4i9z" }, { "sim":51.0, - "partner":"4g2w" + "partner":"4ia0" }, { "sim":51.0, - "partner":"4g2y" + "partner":"4oew" }, { "sim":51.0, - "partner":"4i9z" + "partner":"4oex" }, { "sim":51.0, - "partner":"4ia0" + "partner":"3shy" }, { "sim":51.0, - "partner":"4oew" + "partner":"3shz" }, { "sim":51.0, - "partner":"4oex" + "partner":"3sie" }, { "sim":51.0, - "partner":"3shy" + "partner":"4g2w" }, { "sim":51.0, - "partner":"3shz" + "partner":"4g2y" }, { "sim":51.0, @@ -121686,10 +121976,6 @@ "sim":51.0, "partner":"3wxm" }, - { - "sim":51.0, - "partner":"3c1y" - }, { "sim":51.0, "partner":"3c1z" @@ -121714,6 +122000,10 @@ "sim":51.0, "partner":"4yxm" }, + { + "sim":51.0, + "partner":"3c1y" + }, { "sim":51.0, "partner":"2rjg" @@ -121762,10 +122052,6 @@ "sim":51.0, "partner":"3vvm" }, - { - "sim":51.0, - "partner":"2y6r" - }, { "sim":51.0, "partner":"4a99" @@ -121786,6 +122072,10 @@ "sim":51.0, "partner":"2y6q" }, + { + "sim":51.0, + "partner":"2y6r" + }, { "sim":51.0, "partner":"3k01" @@ -121834,10 +122124,6 @@ "sim":51.0, "partner":"4lf2" }, - { - "sim":51.0, - "partner":"4cdm" - }, { "sim":51.0, "partner":"4cdn" @@ -121850,6 +122136,10 @@ "sim":51.0, "partner":"2xrz" }, + { + "sim":51.0, + "partner":"4cdm" + }, { "sim":51.0, "partner":"3ug3" @@ -121878,10 +122168,6 @@ "sim":51.0, "partner":"3qfb" }, - { - "sim":51.0, - "partner":"2cj9" - }, { "sim":51.0, "partner":"2cja" @@ -121894,6 +122180,10 @@ "sim":51.0, "partner":"2cjb" }, + { + "sim":51.0, + "partner":"2cj9" + }, { "sim":51.0, "partner":"4s21" @@ -121944,11 +122234,11 @@ }, { "sim":50.0, - "partner":"3gz2" + "partner":"4oml" }, { "sim":50.0, - "partner":"4oml" + "partner":"3gz2" }, { "sim":50.0, @@ -122012,15 +122302,15 @@ }, { "sim":50.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":50.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":50.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":50.0, @@ -122068,11 +122358,11 @@ }, { "sim":50.0, - "partner":"2ela" + "partner":"2b6b" }, { "sim":50.0, - "partner":"2b6b" + "partner":"2ela" }, { "sim":50.0, @@ -122108,11 +122398,11 @@ }, { "sim":50.0, - "partner":"4kce" + "partner":"2h66" }, { "sim":50.0, - "partner":"2h66" + "partner":"4kce" }, { "sim":50.0, @@ -122128,11 +122418,11 @@ }, { "sim":50.0, - "partner":"4jr4" + "partner":"4jr6" }, { "sim":50.0, - "partner":"4jr6" + "partner":"4jr4" }, { "sim":50.0, @@ -122158,10 +122448,6 @@ "sim":50.0, "partner":"2fz4" }, - { - "sim":50.0, - "partner":"3la7" - }, { "sim":50.0, "partner":"3la2" @@ -122172,15 +122458,15 @@ }, { "sim":50.0, - "partner":"3r6s" + "partner":"3la7" }, { "sim":50.0, - "partner":"2rde" + "partner":"3r6s" }, { "sim":50.0, - "partner":"4da6" + "partner":"2rde" }, { "sim":50.0, @@ -122234,6 +122520,10 @@ "sim":50.0, "partner":"4d8v" }, + { + "sim":50.0, + "partner":"4da6" + }, { "sim":50.0, "partner":"2yfa" @@ -122248,15 +122538,15 @@ }, { "sim":50.0, - "partner":"1zw3" + "partner":"1zvz" }, { "sim":50.0, - "partner":"1zvz" + "partner":"1zw2" }, { "sim":50.0, - "partner":"1zw2" + "partner":"1zw3" }, { "sim":50.0, @@ -122270,10 +122560,6 @@ "sim":50.0, "partner":"2jfq" }, - { - "sim":50.0, - "partner":"4rdh" - }, { "sim":50.0, "partner":"4rdi" @@ -122298,6 +122584,10 @@ "sim":50.0, "partner":"5djj" }, + { + "sim":50.0, + "partner":"4rdh" + }, { "sim":50.0, "partner":"5djk" @@ -122316,11 +122606,11 @@ }, { "sim":50.0, - "partner":"3ta4" + "partner":"3t9w" }, { "sim":50.0, - "partner":"3t9w" + "partner":"3ta4" }, { "sim":50.0, @@ -122332,19 +122622,19 @@ }, { "sim":50.0, - "partner":"3nha" + "partner":"3nh6" }, { "sim":50.0, - "partner":"3nhb" + "partner":"3nh9" }, { "sim":50.0, - "partner":"3nh6" + "partner":"3nha" }, { "sim":50.0, - "partner":"3nh9" + "partner":"3nhb" }, { "sim":50.0, @@ -122352,31 +122642,31 @@ }, { "sim":50.0, - "partner":"3ggo" + "partner":"3ggp" }, { "sim":50.0, - "partner":"3ggp" + "partner":"3ggg" }, { "sim":50.0, - "partner":"3ggg" + "partner":"3ggo" }, { "sim":50.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":50.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":50.0, - "partner":"3tm8" + "partner":"3tmc" }, { "sim":50.0, - "partner":"3tmb" + "partner":"3tmd" }, { "sim":50.0, @@ -122388,15 +122678,15 @@ }, { "sim":50.0, - "partner":"2pzm" + "partner":"2pzk" }, { "sim":50.0, - "partner":"2pzk" + "partner":"2pzl" }, { "sim":50.0, - "partner":"2pzl" + "partner":"2pzm" }, { "sim":50.0, @@ -122514,10 +122804,6 @@ "sim":50.0, "partner":"3kzk" }, - { - "sim":50.0, - "partner":"4m1i" - }, { "sim":50.0, "partner":"4d8f" @@ -122530,6 +122816,10 @@ "sim":50.0, "partner":"4m1h" }, + { + "sim":50.0, + "partner":"4m1i" + }, { "sim":50.0, "partner":"2b61" @@ -122558,14 +122848,6 @@ "sim":50.0, "partner":"4ocv" }, - { - "sim":50.0, - "partner":"4q3r" - }, - { - "sim":50.0, - "partner":"4q42" - }, { "sim":50.0, "partner":"4q3s" @@ -122600,19 +122882,23 @@ }, { "sim":50.0, - "partner":"3o2t" + "partner":"4q3r" }, { "sim":50.0, - "partner":"3bu7" + "partner":"4q42" }, { "sim":50.0, - "partner":"2xyo" + "partner":"3o2t" }, { "sim":50.0, - "partner":"4hcl" + "partner":"3bu7" + }, + { + "sim":50.0, + "partner":"2xyo" }, { "sim":50.0, @@ -122626,6 +122912,10 @@ "sim":50.0, "partner":"3au7" }, + { + "sim":50.0, + "partner":"4hcl" + }, { "sim":50.0, "partner":"4r9v" @@ -122652,11 +122942,11 @@ }, { "sim":50.0, - "partner":"3wkr" + "partner":"3wks" }, { "sim":50.0, - "partner":"3wks" + "partner":"3wkr" }, { "sim":50.0, @@ -122664,15 +122954,15 @@ }, { "sim":50.0, - "partner":"4euh" + "partner":"4eue" }, { "sim":50.0, - "partner":"4eue" + "partner":"4euf" }, { "sim":50.0, - "partner":"4euf" + "partner":"4euh" }, { "sim":50.0, @@ -122690,17 +122980,13 @@ "sim":50.0, "partner":"2alm" }, - { - "sim":50.0, - "partner":"2yhg" - }, { "sim":50.0, "partner":"4doy" }, { "sim":50.0, - "partner":"3amu" + "partner":"2yhg" }, { "sim":50.0, @@ -122708,11 +122994,11 @@ }, { "sim":50.0, - "partner":"2yjn" + "partner":"3amu" }, { "sim":50.0, - "partner":"2r98" + "partner":"2yjn" }, { "sim":50.0, @@ -122734,6 +123020,10 @@ "sim":50.0, "partner":"4i49" }, + { + "sim":50.0, + "partner":"2r98" + }, { "sim":50.0, "partner":"3qfs" @@ -122798,10 +123088,6 @@ "sim":50.0, "partner":"4tmu" }, - { - "sim":50.0, - "partner":"2r0p" - }, { "sim":50.0, "partner":"2r0c" @@ -122824,19 +123110,19 @@ }, { "sim":50.0, - "partner":"2hiv" + "partner":"2r0p" }, { "sim":50.0, - "partner":"2hix" + "partner":"2hiv" }, { "sim":50.0, - "partner":"3fjo" + "partner":"2hix" }, { "sim":50.0, - "partner":"4gyk" + "partner":"3fjo" }, { "sim":50.0, @@ -122844,7 +123130,7 @@ }, { "sim":50.0, - "partner":"2fw3" + "partner":"4gyk" }, { "sim":50.0, @@ -122866,6 +123152,10 @@ "sim":50.0, "partner":"4eph" }, + { + "sim":50.0, + "partner":"2fw3" + }, { "sim":50.0, "partner":"2bpo" @@ -123001,127 +123291,127 @@ ], "subtitle":"Computationally designed left-handed alpha\/alpha toroid with 6 repeats", "tags":[ - "computationally designed", "toroid", - "rosetta", "de novo protein", + "left-handed", + "rosetta", "alpha helix", - "left-handed" + "computationally designed" ], "keywords":[ - "hence", - "carboxy", - "rely", - "architecture", + "repeats", + "purely", + "engineering", "reference", - "crystallography", - "peptide", - "roles", - "scaffolding", - "designed", - "validation", - "example", - "local", + "constrained", + "cavities", + "structural", + "development", + "repeat", "methods", + "information", + "families", + "roles", + "extended", + "carboxy", + "protein", + "successfully", + "helical", + "binding", + "rapid", + "defining", + "novo", + "domains", + "procedure", + "repetition", + "previous", "geometric", - "sequences", - "bind", - "structure", - "c", - "repeat", - "recombination", - "applied", - "database", - "duplication", - "building", - "conformations", - "catalysis", - "molecule", - "without", - "architectures", - "proteins", + "construction", "play", - "defining", + "knowledge", "enables", + "taken", + "formed", + "closed", + "overall", "dna", - "de", - "enzymes", - "produce", - "criteria", - "successfully", - "seen", - "small", - "highly", - "simple", - "yet", - "materials", - "nature", - "constrained", - "procedure", - "units", - "structures", - "juxtapose", + "biological", "macromolecular", - "natural", - "assembly", - "suitable", - "fibrous", - "rapid", - "series", - "taken", - "amino", - "families", - "geometry", - "extended", "rna", - "ranging", - "report", - "template", - "information", - "tandem", "surfaces", - "approaches", - "dictated", - "engineering", + "bind", "blocks", - "several", - "design", - "helical", - "present", - "existing", - "cavities", - "sequence", - "repeats", - "biological", + "proteins", + "criteria", "packing", - "structural", - "diversification", - "important", + "several", + "tandem", + "modular", + "units", + "enzymes", + "architecture", + "highly", + "small", "compact", + "termini", + "duplication", + "computational", + "peptide", + "molecule", + "local", + "c", + "design", "diverse", - "overall", - "closed", - "construction", + "natural", + "simple", + "hence", + "yet", + "produce", + "assembly", "n", - "novo", "driven", - "purely", - "repetition", - "modular", - "folds", + "template", + "seen", + "architectures", + "juxtapose", + "amino", + "diversification", "validated", - "domains", + "series", + "applied", + "sequence", + "building", + "present", + "recombination", + "materials", + "validation", + "folds", + "catalysis", + "designed", "partners", - "binding", - "protein", - "termini", - "previous", - "knowledge", - "development", - "computational", + "example", + "sequences", "unlike", + "geometry", + "structures", + "de", + "ranging", + "suitable", + "approaches", + "without", + "structure", + "important", + "dictated", + "rely", + "report", + "crystallography", + "nature", "internal", - "formed" + "scaffolding", + "conformations", + "existing", + "database", + "fibrous" ], "release_date":"2015-12-16", "publication":"\"Rational design of alpha-helical tandem repeat proteins with closed architectures\", Nature, 528, 585-588", @@ -123250,127 +123540,127 @@ ], "subtitle":"Computationally designed left-handed alpha\/alpha toroid with 9 repeats; two linked rings of 12 repeats each structure", "tags":[ - "computationally designed", "toroid", - "rosetta", "de novo protein", + "left-handed", + "rosetta", "alpha helix", - "left-handed" + "computationally designed" ], "keywords":[ - "hence", - "carboxy", - "rely", - "architecture", + "repeats", + "purely", + "engineering", "reference", - "crystallography", - "peptide", - "roles", - "scaffolding", - "designed", - "validation", - "example", - "local", + "constrained", + "cavities", + "structural", + "development", + "repeat", "methods", + "information", + "families", + "roles", + "extended", + "carboxy", + "protein", + "successfully", + "helical", + "binding", + "rapid", + "defining", + "novo", + "domains", + "procedure", + "repetition", + "previous", "geometric", - "sequences", - "bind", - "structure", - "c", - "repeat", - "recombination", - "applied", - "database", - "duplication", - "building", - "conformations", - "catalysis", - "molecule", - "without", - "architectures", - "proteins", + "construction", "play", - "defining", + "knowledge", "enables", + "taken", + "formed", + "closed", + "overall", "dna", - "de", - "enzymes", - "produce", - "criteria", - "successfully", - "seen", - "small", - "highly", - "simple", - "yet", - "materials", - "nature", - "constrained", - "procedure", - "units", - "structures", - "juxtapose", + "biological", "macromolecular", - "natural", - "assembly", - "suitable", - "fibrous", - "rapid", - "series", - "taken", - "amino", - "families", - "geometry", - "extended", "rna", - "ranging", - "report", - "template", - "information", - "tandem", "surfaces", - "approaches", - "dictated", - "engineering", + "bind", "blocks", - "several", - "design", - "helical", - "present", - "existing", - "cavities", - "sequence", - "repeats", - "biological", + "proteins", + "criteria", "packing", - "structural", - "diversification", - "important", + "several", + "tandem", + "modular", + "units", + "enzymes", + "architecture", + "highly", + "small", "compact", + "termini", + "duplication", + "computational", + "peptide", + "molecule", + "local", + "c", + "design", "diverse", - "overall", - "closed", - "construction", + "natural", + "simple", + "hence", + "yet", + "produce", + "assembly", "n", - "novo", "driven", - "purely", - "repetition", - "modular", - "folds", + "template", + "seen", + "architectures", + "juxtapose", + "amino", + "diversification", "validated", - "domains", + "series", + "applied", + "sequence", + "building", + "present", + "recombination", + "materials", + "validation", + "folds", + "catalysis", + "designed", "partners", - "binding", - "protein", - "termini", - "previous", - "knowledge", - "development", - "computational", + "example", + "sequences", "unlike", + "geometry", + "structures", + "de", + "ranging", + "suitable", + "approaches", + "without", + "structure", + "important", + "dictated", + "rely", + "report", + "crystallography", + "nature", "internal", - "formed" + "scaffolding", + "conformations", + "existing", + "database", + "fibrous" ], "release_date":"2015-12-16", "publication":"\"Rational design of alpha-helical tandem repeat proteins with closed architectures\", Nature, 528, 585-588", @@ -123594,127 +123884,127 @@ ], "subtitle":"Computationally designed left-handed alpha\/alpha toroid with 9 repeats", "tags":[ - "computationally designed", "toroid", - "rosetta", "de novo protein", + "left-handed", + "rosetta", "alpha helix", - "left-handed" + "computationally designed" ], "keywords":[ - "hence", - "carboxy", - "rely", - "architecture", + "repeats", + "purely", + "engineering", "reference", - "crystallography", - "peptide", - "roles", - "scaffolding", - "designed", - "validation", - "example", - "local", + "constrained", + "cavities", + "structural", + "development", + "repeat", "methods", + "information", + "families", + "roles", + "extended", + "carboxy", + "protein", + "successfully", + "helical", + "binding", + "rapid", + "defining", + "novo", + "domains", + "procedure", + "repetition", + "previous", "geometric", - "sequences", - "bind", - "structure", - "c", - "repeat", - "recombination", - "applied", - "database", - "duplication", - "building", - "conformations", - "catalysis", - "molecule", - "without", - "architectures", - "proteins", + "construction", "play", - "defining", + "knowledge", "enables", + "taken", + "formed", + "closed", + "overall", "dna", - "de", - "enzymes", - "produce", - "criteria", - "successfully", - "seen", - "small", - "highly", - "simple", - "yet", - "materials", - "nature", - "constrained", - "procedure", - "units", - "structures", - "juxtapose", + "biological", "macromolecular", - "natural", - "assembly", - "suitable", - "fibrous", - "rapid", - "series", - "taken", - "amino", - "families", - "geometry", - "extended", "rna", - "ranging", - "report", - "template", - "information", - "tandem", "surfaces", - "approaches", - "dictated", - "engineering", + "bind", "blocks", - "several", - "design", - "helical", - "present", - "existing", - "cavities", - "sequence", - "repeats", - "biological", + "proteins", + "criteria", "packing", - "structural", - "diversification", - "important", + "several", + "tandem", + "modular", + "units", + "enzymes", + "architecture", + "highly", + "small", "compact", + "termini", + "duplication", + "computational", + "peptide", + "molecule", + "local", + "c", + "design", "diverse", - "overall", - "closed", - "construction", + "natural", + "simple", + "hence", + "yet", + "produce", + "assembly", "n", - "novo", "driven", - "purely", - "repetition", - "modular", - "folds", + "template", + "seen", + "architectures", + "juxtapose", + "amino", + "diversification", "validated", - "domains", + "series", + "applied", + "sequence", + "building", + "present", + "recombination", + "materials", + "validation", + "folds", + "catalysis", + "designed", "partners", - "binding", - "protein", - "termini", - "previous", - "knowledge", - "development", - "computational", + "example", + "sequences", "unlike", + "geometry", + "structures", + "de", + "ranging", + "suitable", + "approaches", + "without", + "structure", + "important", + "dictated", + "rely", + "report", + "crystallography", + "nature", "internal", - "formed" + "scaffolding", + "conformations", + "existing", + "database", + "fibrous" ], "release_date":"2015-12-16", "publication":"\"Rational design of alpha-helical tandem repeat proteins with closed architectures\", Nature, 528, 585-588", @@ -123843,127 +124133,127 @@ ], "subtitle":"Computationally designed left-handed alpha\/alpha toroid with 3 repeats in space group p212121", "tags":[ - "computationally designed", "toroid", - "rosetta", "de novo protein", + "left-handed", + "rosetta", "alpha helix", - "left-handed" + "computationally designed" ], "keywords":[ - "hence", - "carboxy", - "rely", - "architecture", + "repeats", + "purely", + "engineering", "reference", - "crystallography", - "peptide", - "roles", - "scaffolding", - "designed", - "validation", - "example", - "local", + "constrained", + "cavities", + "structural", + "development", + "repeat", "methods", + "information", + "families", + "roles", + "extended", + "carboxy", + "protein", + "successfully", + "helical", + "binding", + "rapid", + "defining", + "novo", + "domains", + "procedure", + "repetition", + "previous", "geometric", - "sequences", - "bind", - "structure", - "c", - "repeat", - "recombination", - "applied", - "database", - "duplication", - "building", - "conformations", - "catalysis", - "molecule", - "without", - "architectures", - "proteins", + "construction", "play", - "defining", + "knowledge", "enables", + "taken", + "formed", + "closed", + "overall", "dna", - "de", - "enzymes", - "produce", - "criteria", - "successfully", - "seen", - "small", - "highly", - "simple", - "yet", - "materials", - "nature", - "constrained", - "procedure", - "units", - "structures", - "juxtapose", + "biological", "macromolecular", - "natural", - "assembly", - "suitable", - "fibrous", - "rapid", - "series", - "taken", - "amino", - "families", - "geometry", - "extended", "rna", - "ranging", - "report", - "template", - "information", - "tandem", "surfaces", - "approaches", - "dictated", - "engineering", + "bind", "blocks", - "several", - "design", - "helical", - "present", - "existing", - "cavities", - "sequence", - "repeats", - "biological", + "proteins", + "criteria", "packing", - "structural", - "diversification", - "important", + "several", + "tandem", + "modular", + "units", + "enzymes", + "architecture", + "highly", + "small", "compact", + "termini", + "duplication", + "computational", + "peptide", + "molecule", + "local", + "c", + "design", "diverse", - "overall", - "closed", - "construction", + "natural", + "simple", + "hence", + "yet", + "produce", + "assembly", "n", - "novo", "driven", - "purely", - "repetition", - "modular", - "folds", + "template", + "seen", + "architectures", + "juxtapose", + "amino", + "diversification", "validated", - "domains", + "series", + "applied", + "sequence", + "building", + "present", + "recombination", + "materials", + "validation", + "folds", + "catalysis", + "designed", "partners", - "binding", - "protein", - "termini", - "previous", - "knowledge", - "development", - "computational", + "example", + "sequences", "unlike", + "geometry", + "structures", + "de", + "ranging", + "suitable", + "approaches", + "without", + "structure", + "important", + "dictated", + "rely", + "report", + "crystallography", + "nature", "internal", - "formed" + "scaffolding", + "conformations", + "existing", + "database", + "fibrous" ], "release_date":"2015-12-16", "publication":"\"Rational design of alpha-helical tandem repeat proteins with closed architectures\", Nature, 528, 585-588", @@ -124083,127 +124373,127 @@ ], "subtitle":"Computationally designed left-handed alpha\/alpha toroid with 3 repeats in space group p43212", "tags":[ - "computationally designed", "toroid", - "rosetta", "de novo protein", + "left-handed", + "rosetta", "alpha helix", - "left-handed" + "computationally designed" ], "keywords":[ - "hence", - "carboxy", - "rely", - "architecture", + "repeats", + "purely", + "engineering", "reference", - "crystallography", - "peptide", - "roles", - "scaffolding", - "designed", - "validation", - "example", - "local", + "constrained", + "cavities", + "structural", + "development", + "repeat", "methods", + "information", + "families", + "roles", + "extended", + "carboxy", + "protein", + "successfully", + "helical", + "binding", + "rapid", + "defining", + "novo", + "domains", + "procedure", + "repetition", + "previous", "geometric", - "sequences", - "bind", - "structure", - "c", - "repeat", - "recombination", - "applied", - "database", - "duplication", - "building", - "conformations", - "catalysis", - "molecule", - "without", - "architectures", - "proteins", + "construction", "play", - "defining", + "knowledge", "enables", + "taken", + "formed", + "closed", + "overall", "dna", - "de", - "enzymes", - "produce", - "criteria", - "successfully", - "seen", - "small", - "highly", - "simple", - "yet", - "materials", - "nature", - "constrained", - "procedure", - "units", - "structures", - "juxtapose", + "biological", "macromolecular", - "natural", - "assembly", - "suitable", - "fibrous", - "rapid", - "series", - "taken", - "amino", - "families", - "geometry", - "extended", "rna", - "ranging", - "report", - "template", - "information", - "tandem", "surfaces", - "approaches", - "dictated", - "engineering", + "bind", "blocks", - "several", - "design", - "helical", - "present", - "existing", - "cavities", - "sequence", - "repeats", - "biological", + "proteins", + "criteria", "packing", - "structural", - "diversification", - "important", + "several", + "tandem", + "modular", + "units", + "enzymes", + "architecture", + "highly", + "small", "compact", + "termini", + "duplication", + "computational", + "peptide", + "molecule", + "local", + "c", + "design", "diverse", - "overall", - "closed", - "construction", + "natural", + "simple", + "hence", + "yet", + "produce", + "assembly", "n", - "novo", "driven", - "purely", - "repetition", - "modular", - "folds", + "template", + "seen", + "architectures", + "juxtapose", + "amino", + "diversification", "validated", - "domains", + "series", + "applied", + "sequence", + "building", + "present", + "recombination", + "materials", + "validation", + "folds", + "catalysis", + "designed", "partners", - "binding", - "protein", - "termini", - "previous", - "knowledge", - "development", - "computational", + "example", + "sequences", "unlike", + "geometry", + "structures", + "de", + "ranging", + "suitable", + "approaches", + "without", + "structure", + "important", + "dictated", + "rely", + "report", + "crystallography", + "nature", "internal", - "formed" + "scaffolding", + "conformations", + "existing", + "database", + "fibrous" ], "release_date":"2015-12-16", "publication":"\"Rational design of alpha-helical tandem repeat proteins with closed architectures\", Nature, 528, 585-588", @@ -124307,11 +124597,11 @@ "subtitle":"Directed evolutionary changes in kemp eliminase ke07 - crystal 1 ke07 design", "tags":[ "de novo protein, lyase", - "kemp eliminase", - "ke07", "de novo protein", + "ke07", "directed evolution", - "lyase" + "lyase", + "kemp eliminase" ], "keywords":[ "description", @@ -124352,11 +124642,11 @@ }, { "sim":527.0, - "partner":"5d2v" + "partner":"5d2t" }, { "sim":527.0, - "partner":"5d2t" + "partner":"5d2v" }, { "sim":516.0, @@ -124364,11 +124654,11 @@ }, { "sim":516.0, - "partner":"5d2x" + "partner":"5d2y" }, { "sim":516.0, - "partner":"5d2y" + "partner":"5d2x" }, { "sim":509.0, @@ -124482,11 +124772,11 @@ }, { "sim":144.0, - "partner":"1jvn" + "partner":"1ox5" }, { "sim":144.0, - "partner":"1ox5" + "partner":"1jvn" }, { "sim":144.0, @@ -124690,8 +124980,8 @@ "subtitle":"Crystal structure of collagen-like peptide at 1.27 angstrom resolution", "tags":[ "triple helix", - "collagen", - "structural protein" + "structural protein", + "collagen" ], "keywords":[ "description", @@ -124797,11 +125087,11 @@ ], "subtitle":"Crystal structure of nvpizza2-s16s58", "tags":[ - "self-assembling", - "beta-propeller", - "computational protein design", "permutation", - "de novo protein" + "de novo protein", + "computational protein design", + "beta-propeller", + "self-assembling" ], "keywords":[ "description", @@ -124842,11 +125132,11 @@ }, { "sim":173.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":173.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":172.0, @@ -124858,19 +125148,19 @@ }, { "sim":166.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":166.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":166.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":166.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":166.0, @@ -124878,11 +125168,11 @@ }, { "sim":166.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":166.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":166.0, @@ -124890,7 +125180,7 @@ }, { "sim":166.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":165.0, @@ -124902,15 +125192,15 @@ }, { "sim":164.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":164.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":164.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":164.0, @@ -124918,15 +125208,15 @@ }, { "sim":163.0, - "partner":"7zcj" + "partner":"7zq2" }, { "sim":163.0, - "partner":"7zq2" + "partner":"7zqg" }, { "sim":163.0, - "partner":"7zqg" + "partner":"7zcj" }, { "sim":161.0, @@ -124946,11 +125236,11 @@ }, { "sim":160.0, - "partner":"6i3a" + "partner":"6i39" }, { "sim":160.0, - "partner":"6i39" + "partner":"6i3a" }, { "sim":160.0, @@ -124962,11 +125252,11 @@ }, { "sim":156.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":156.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":156.0, @@ -124974,17 +125264,17 @@ }, { "sim":156.0, - "partner":"6ren" + "partner":"6reo" } ], "seq_thr_sim_natural":[ { "sim":123.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":123.0, - "partner":"1rwi" + "partner":"1rwl" } ], "struct_thr_sim_designed":[ @@ -125086,7 +125376,7 @@ }, "seq_max_sim_natural":{ "sim":123.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9700000286, @@ -125216,114 +125506,114 @@ ], "subtitle":"Crystal structure of the artificial alpharep-7 octarellinv.1 complex", "tags":[ - "rossmann-like", - "artificial protein", "de novo protein", + "artificial protein", + "rossmann-like", "synthetic gene" ], "keywords":[ - "evolution", "v", - "us", + "art", + "experimental", + "differs", + "13", + "surprising", + "free", + "scoring", "10years", + "resemblance", + "protein", + "propose", + "formidable", + "ago", + "none", + "next", + "\u03b1\u03b2\u03b1", + "runs", + "novo", + "test", + "operated", + "stable", + "attractive", + "100", + "using", + "similar", + "creating", + "tertiary", + "complex", + "algorithms", + "soluble", + "us", "thus", + "automated", + "50", + "functions", + "intended", + "exploiting", + "proteins", + "accuracy", "architecture", + "predict", + "found", + "suggesting", + "evolution", + "features", + "tools", + "gave", + "set", + "obtained", + "lack", + "local", + "actual", + "designing", + "octarellin", + "design", + "impressive", "selection", - "challenge", - "test", + "instead", + "used", + "natural", + "tested", + "fold", + "addition", + "webservers", "prediction", - "local", + "bears", + "fail", + "amino", "improved", - "determined", - "features", - "instead", - "next", - "sequences", - "software", - "opportunity", - "designing", - "structure", - "intended", - "predict", - "pressure", - "successes", - "surprising", - "suggesting", - "proteins", + "sandwich", + "promising", + "predicted", + "crystals", "unique", - "similar", + "could", + "evolutionary", + "directed", + "sequences", + "one", "de", - "fail", - "\u03b1\u03b2\u03b1", - "tools", - "ranking", "remains", - "used", - "evolutionary", - "natural", - "tertiary", - "runs", - "free", "crystallization", - "100", - "obtained", - "amino", - "formidable", + "structure", + "determined", + "ranking", + "chaperons", + "state", + "biophysical", + "silico", "artificial", + "software", + "sample", "acids", - "functions", - "impressive", "result", - "design", - "scoring", - "soluble", - "using", - "propose", - "differs", - "promising", - "could", - "actual", - "13", - "predicted", - "sample", - "accuracy", + "pressure", "despite", - "tested", - "one", - "lack", - "octarellin", - "novo", - "stable", - "gave", - "attractive", - "experimental", - "directed", - "fold", "human", - "resemblance", - "ago", - "art", - "found", - "bears", - "exploiting", - "50", - "none", - "state", - "creating", - "automated", - "webservers", - "set", - "addition", - "protein", - "chaperons", - "complex", - "algorithms", - "silico", - "sandwich", + "challenge", + "successes", "selecting", - "biophysical", - "crystals", - "operated" + "opportunity" ], "release_date":"2016-05-25", "publication":"\"The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools\", J.Struct.Biol., 195, 19-30", @@ -125506,53 +125796,53 @@ "affimer" ], "keywords":[ - "work", - "plays", - "analysis", + "superior", + "surface", "rationale", - "studies", + "analysis", + "design", + "role", + "development", + "value", + "key", + "work", "represents", - "phage", + "display", + "detailed", "thus", + "identified", + "inform", "report", - "although", - "detailed", "inhibitor", + "although", + "candidates", "experiments", - "peptide", - "identify", - "interface", - "adhiron", - "anticancer", - "value", - "necessary", - "p300", - "identified", "target", + "necessary", + "biophysical", + "inhibitors", + "plays", + "understanding", + "anticancer", + "binding", + "metabolism", + "interaction", "several", - "design", - "regions", - "inform", - "using", - "superior", - "development", - "surface", - "tumor", + "phage", + "identify", "high", - "display", - "future", + "tumor", "native", + "interface", + "p300", "motifs", - "understanding", - "inhibitors", - "key", - "metabolism", - "candidates", - "role", - "novel", - "binding", - "biophysical", - "interaction" + "studies", + "adhiron", + "future", + "using", + "regions", + "peptide", + "novel" ], "release_date":"2015-07-15", "publication":"\"Exploration of the Hif-1Alpha.P300 Interface Using Peptide and Adhiron Phage Display Technologies\", Mol.Biosyst., 11, 2738", @@ -125585,19 +125875,19 @@ "seq_thr_sim_designed":[ { "sim":145.0, - "partner":"7zqa" + "partner":"7zq8" }, { "sim":145.0, - "partner":"7zq8" + "partner":"7zqa" }, { "sim":125.0, - "partner":"4n6t" + "partner":"4n6u" }, { "sim":125.0, - "partner":"4n6u" + "partner":"4n6t" } ], "seq_thr_sim_natural":[ @@ -125615,11 +125905,11 @@ }, { "sim":88.0, - "partner":"3ul6" + "partner":"3ul5" }, { "sim":88.0, - "partner":"3ul5" + "partner":"3ul6" }, { "sim":87.0, @@ -125642,7 +125932,7 @@ ], "seq_max_sim_designed":{ "sim":145.0, - "partner":"7zqa" + "partner":"7zq8" }, "seq_max_sim_natural":{ "sim":95.0, @@ -125716,123 +126006,123 @@ ], "subtitle":"Designed armadillo repeat protein yiiim5aii in complex with peptide (kr)5", "tags":[ - "alpha-helical protein", "de novo protein", "protein-peptide complex", "solenoid protein", + "alpha-helical protein", "repeat protein" ], "keywords":[ - "consecutive", - "studies", - "restricted", + "affinity", + "repeats", + "engineering", + "individual", + "recognition", + "regularity", + "development", + "resolution", + "repeat", + "number", + "reflected", + "side", + "within", + "short", + "protein", + "six", + "5", + "binding", + "stretches", + "extensive", + "confirmed", + "manner", + "ground", + "crystal", + "chains", + "complex", + "however", + "kr", + "confirming", + "lysine", + "armadillo", + "adds", "thus", + "stretched", + "residues", "comprehensive", - "modules", - "peptide", - "interacts", - "designed", - "five", - "crystal", - "target", - "based", + "lays", + "uniform", + "proves", + "lengths", "bind", - "module", - "narmrp", + "proteins", + "modules", + "characterization", + "modular", "dipeptide", - "structure", - "repeat", - "recognized", - "however", - "affinity", "increment", - "consistent", - "truly", - "like", - "interaction", - "reflected", - "darmrp", - "5", - "lysine", + "four", "longer", - "tailored", - "proteins", - "arginine", - "\u00e5", - "imperfect", - "manner", - "number", - "cognate", - "rendered", - "short", - "suggests", - "dependency", + "restricted", + "like", + "importance", + "peptide", + "obtained", + "mutagenesis", + "design", + "energy", + "length", "binders", - "stretches", - "recognition", - "modularity", - "alternating", - "individual", - "lengths", - "internal", + "suggests", "natural", + "different", "assembly", - "armadillo", - "stretched", - "extensive", - "obtained", - "regularity", + "also", + "usually", "amino", - "report", - "resolution", - "four", - "acids", - "specificities", "mode", - "adds", - "true", - "engineering", - "six", - "unit", - "design", - "characterization", - "confirming", - "constant", - "repeats", - "energy", - "usually", - "confirmation", - "lays", - "importance", - "exponential", - "chains", - "one", - "proves", - "also", - "length", + "alternating", + "narmrp", + "interaction", + "modularity", + "interacts", "peptides", - "modular", - "confirmed", - "residues", - "regularized", + "relationship", + "identical", + "cycles", + "truly", + "rendered", + "recognized", "reveal", - "different", - "affinities", - "kr", + "designed", + "regularized", + "consecutive", + "five", + "cognate", + "one", + "confirmation", + "true", + "specificities", + "tailored", + "exponential", + "based", + "\u00e5", + "module", + "structure", + "report", + "target", + "dependency", + "unit", + "internal", "systematic", - "cycles", - "ground", - "protein", - "uniform", - "identical", - "complex", - "development", - "relationship", - "within", - "side", - "binding", + "arginine", + "constant", + "acids", + "darmrp", + "studies", "depend", - "mutagenesis" + "affinities", + "imperfect", + "consistent" ], "release_date":"2016-03-30", "publication":"\"Structure and Energetic Contributions of a Designed Modular Peptide-Binding Protein with Picomolar Affinity\", J.Am.Chem.Soc., 138, 3526", @@ -125865,23 +126155,23 @@ "seq_thr_sim_designed":[ { "sim":538.0, - "partner":"5mfh" + "partner":"5mfe" }, { "sim":538.0, - "partner":"5mfn" + "partner":"5mff" }, { "sim":538.0, - "partner":"5mff" + "partner":"5mfg" }, { "sim":538.0, - "partner":"5mfg" + "partner":"5mfh" }, { "sim":538.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":517.0, @@ -125905,11 +126195,11 @@ }, { "sim":512.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":512.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":504.0, @@ -125965,11 +126255,11 @@ }, { "sim":309.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":309.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":297.0, @@ -126075,15 +126365,15 @@ }, { "sim":185.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":185.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":185.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":185.0, @@ -126121,10 +126411,6 @@ "sim":178.0, "partner":"4u54" }, - { - "sim":178.0, - "partner":"4u5o" - }, { "sim":178.0, "partner":"3ve6" @@ -126155,15 +126441,15 @@ }, { "sim":178.0, - "partner":"3l3q" + "partner":"4u5o" }, { "sim":178.0, - "partner":"3btr" + "partner":"3l3q" }, { "sim":178.0, - "partner":"1y2a" + "partner":"3btr" }, { "sim":178.0, @@ -126171,11 +126457,11 @@ }, { "sim":178.0, - "partner":"1ial" + "partner":"1y2a" }, { "sim":178.0, - "partner":"3q5u" + "partner":"1ial" }, { "sim":178.0, @@ -126183,15 +126469,15 @@ }, { "sim":178.0, - "partner":"1ejl" + "partner":"4yi0" }, { "sim":178.0, - "partner":"4yi0" + "partner":"3knd" }, { "sim":178.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":178.0, @@ -126199,11 +126485,11 @@ }, { "sim":178.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":178.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":178.0, @@ -126211,7 +126497,7 @@ }, { "sim":178.0, - "partner":"3zir" + "partner":"3q5u" }, { "sim":178.0, @@ -126233,6 +126519,10 @@ "sim":178.0, "partner":"3ziq" }, + { + "sim":178.0, + "partner":"3zir" + }, { "sim":178.0, "partner":"4uaf" @@ -126265,10 +126555,6 @@ "sim":178.0, "partner":"4ba3" }, - { - "sim":178.0, - "partner":"4htv" - }, { "sim":178.0, "partner":"4mz5" @@ -126279,15 +126565,7 @@ }, { "sim":178.0, - "partner":"3rzx" - }, - { - "sim":178.0, - "partner":"5e6q" - }, - { - "sim":178.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":178.0, @@ -126329,6 +126607,18 @@ "sim":178.0, "partner":"3uvu" }, + { + "sim":178.0, + "partner":"3rzx" + }, + { + "sim":178.0, + "partner":"5e6q" + }, + { + "sim":178.0, + "partner":"3oqs" + }, { "sim":178.0, "partner":"5huw" @@ -126393,7 +126683,7 @@ ], "seq_max_sim_designed":{ "sim":538.0, - "partner":"5mfh" + "partner":"5mfe" }, "seq_max_sim_natural":{ "sim":507.0, @@ -126476,63 +126766,63 @@ "subtitle":"Crystal structure of a mutant of chignolin, cln025", "tags":[ "de novo protein", + "mini-protein", "beta-hairpin", - "miniature protein", - "mini-protein" + "miniature protein" ], "keywords":[ - "stability", - "thermal", - "without", - "question", - "consisting", - "characteristics", - "despite", - "answer", - "amino", - "network", - "proteins", - "pathway", - "us", - "established", - "whether", - "smallest", - "among", - "acids", + "molecule", "designed", - "define", + "whether", + "surface", "kind", - "10", - "small", - "simple", + "revealed", + "energy", "inquiring", - "existence", - "nature", - "crystal", + "impels", "ideal", - "deepens", - "protein", - "actually", "natural", - "surface", - "describe", - "essential", + "simple", + "us", + "question", + "define", + "consisting", + "free", + "properties", + "without", "structure", - "solution", - "revealed", - "definition", - "impels", - "size", - "energy", - "understanding", - "scientists", + "among", "folding", - "free", - "consistent", + "scientists", "occurs", - "molecule", + "thermal", + "protein", + "network", + "existence", + "nature", + "amino", + "stability", + "understanding", + "proteins", + "solution", + "size", + "essential", "consensus", - "properties" + "established", + "pathway", + "answer", + "definition", + "small", + "deepens", + "acids", + "despite", + "crystal", + "actually", + "describe", + "10", + "characteristics", + "smallest", + "consistent" ], "release_date":"2015-08-12", "publication":"\"Crystal structure of a ten-amino acid protein\", J.Am.Chem.Soc., 130, 15327-15331", @@ -126672,95 +126962,95 @@ ], "subtitle":"Engineered digoxigenin binder dig5.1a", "tags":[ - "computationally designed", + "digoxigenin", "designed", - "de novo protein", "ligand binder", + "de novo protein", "engineered", - "digoxigenin" + "computationally designed" ], "keywords":[ - "providing", - "still", - "designed", - "eleven", - "current", - "11", + "digoxigenin", + "affinity", "methods", - "order", - "sequences", - "bind", - "8", - "structure", + "well", + "ranks", + "conducted", + "13", + "three", + "ligands", "docking", - "predict", - "able", - "community", - "affinity", - "steroids", - "phase", - "molecule", + "protein", "5", - "poses", - "proteins", - "investigated", - "atoms", - "absolute", - "small", - "difficult", - "resource", - "ability", - "14", - "three", - "conducted", - "pkd", - "appropriate", + "rank", + "binding", "phases", - "ligands", - "first", - "second", - "consisted", - "digoxigenin", - "identify", + "pose", + "two", + "related", "10", - "exercise", "correctly", - "challenged", - "design", - "task", + "correct", + "resource", + "select", + "able", + "ligand", + "eleven", + "residues", + "phase", + "steroids", + "bind", + "bound", + "proteins", + "small", + "predict", + "absolute", + "found", + "computational", "required", - "sequence", - "csar", + "11", + "set", + "molecule", + "task", + "design", + "current", + "decoy", + "exercise", "participants", - "correlate", - "13", - "plausible", "benchmark", - "ligand", - "pose", - "one", + "still", + "atoms", + "third", + "appropriate", "groups", + "csar", + "14", + "pkd", + "challenged", "evaluate", + "backbone", + "ability", + "plausible", + "sequence", + "scores", + "designed", + "order", + "sequences", + "community", + "investigated", + "one", + "providing", + "poses", + "correlate", + "first", + "consisted", + "structure", "congeneric", - "select", - "well", - "residues", - "found", + "identify", + "difficult", + "second", "affinities", - "two", - "correct", - "set", - "protein", - "bound", - "scores", - "backbone", - "third", - "decoy", - "rank", - "computational", - "binding", - "ranks", - "related" + "8" ], "release_date":"2015-10-28", "publication":"\"CSAR Benchmark Exercise 2013: Evaluation of Results from a Combined Computational Protein Design, Docking, and Scoring\/Ranking Challenge\", J.Chem.Inf.Model., 56, 1022-1031", @@ -126810,14 +127100,6 @@ "sim":89.0, "partner":"1s5a" }, - { - "sim":50.0, - "partner":"3jun" - }, - { - "sim":50.0, - "partner":"3juo" - }, { "sim":50.0, "partner":"3jup" @@ -126849,6 +127131,14 @@ { "sim":50.0, "partner":"3jum" + }, + { + "sim":50.0, + "partner":"3jun" + }, + { + "sim":50.0, + "partner":"3juo" } ], "struct_thr_sim_designed":[ @@ -126925,77 +127215,77 @@ ], "subtitle":"Crystal structure of a de novo designed tim-barrel", "tags":[ - "idealized scaffold", "computational design", "de novo protein", - "tim-barrel" + "tim-barrel", + "idealized scaffold" ], "keywords":[ - "guided", - "opens", - "designs", - "importance", - "years", - "despite", - "suggesting", - "strand", - "proteins", - "available", - "defining", - "possibilities", - "chemical", + "designed", + "sampled", + "naturally", + "design", + "revealed", + "space", + "indicate", + "repeat", + "principles", "thermostable", - "25", - "barrels", + "nearly", + "opens", + "geometrical", "de", - "novo", - "bonds", - "efforts", - "similarities", - "enzymes", - "succeeded", "experimental", + "efforts", + "side", + "structure", "fold", - "identify", - "designed", - "register", - "sensitive", - "subset", - "nature", - "crystal", - "geometrical", - "occurring", - "ability", + "bonds", "new", - "design", + "symmetrical", + "similarities", + "subset", "model", + "protein", + "nature", + "25", + "known", + "proteins", + "33", + "searches", "characterization", + "defining", + "guided", + "identify", "units", - "achieving", - "symmetrical", - "protein", - "8", - "naturally", + "strand", + "novo", + "ability", + "enzymes", + "hydrogen", + "register", + "sequence", + "years", + "available", + "possibilities", "tim", - "distant", "identical", - "searches", - "space", + "superfamilies", + "suggesting", + "despite", + "achieving", + "succeeded", + "chemical", + "crystal", + "distant", "describe", - "structure", - "sequence", - "repeat", - "revealed", - "indicate", + "designs", "computational", - "33", - "principles", - "side", - "nearly", - "known", - "sampled", - "hydrogen", - "superfamilies" + "importance", + "8", + "barrels", + "occurring", + "sensitive" ], "release_date":"2015-11-18", "publication":"\"De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy\", Nat.Chem.Biol., 12, 29-34", @@ -127032,11 +127322,11 @@ }, { "sim":397.0, - "partner":"7ot7" + "partner":"7osu" }, { "sim":397.0, - "partner":"7osu" + "partner":"7ot7" }, { "sim":387.0, @@ -127172,127 +127462,127 @@ ], "subtitle":"Computationally designed left-handed alpha\/alpha toroid with 12 repeats", "tags":[ - "computationally designed", "toroid", - "rosetta", "de novo protein", + "left-handed", + "rosetta", "alpha helix", - "left-handed" + "computationally designed" ], "keywords":[ - "hence", - "carboxy", - "rely", - "architecture", + "repeats", + "purely", + "engineering", "reference", - "crystallography", - "peptide", - "roles", - "scaffolding", - "designed", - "validation", - "example", - "local", + "constrained", + "cavities", + "structural", + "development", + "repeat", "methods", + "information", + "families", + "roles", + "extended", + "carboxy", + "protein", + "successfully", + "helical", + "binding", + "rapid", + "defining", + "novo", + "domains", + "procedure", + "repetition", + "previous", "geometric", - "sequences", - "bind", - "structure", - "c", - "repeat", - "recombination", - "applied", - "database", - "duplication", - "building", - "conformations", - "catalysis", - "molecule", - "without", - "architectures", - "proteins", + "construction", "play", - "defining", + "knowledge", "enables", + "taken", + "formed", + "closed", + "overall", "dna", - "de", - "enzymes", - "produce", - "criteria", - "successfully", - "seen", - "small", - "highly", - "simple", - "yet", - "materials", - "nature", - "constrained", - "procedure", - "units", - "structures", - "juxtapose", + "biological", "macromolecular", - "natural", - "assembly", - "suitable", - "fibrous", - "rapid", - "series", - "taken", - "amino", - "families", - "geometry", - "extended", "rna", - "ranging", - "report", - "template", - "information", - "tandem", "surfaces", - "approaches", - "dictated", - "engineering", + "bind", "blocks", - "several", - "design", - "helical", - "present", - "existing", - "cavities", - "sequence", - "repeats", - "biological", + "proteins", + "criteria", "packing", - "structural", - "diversification", - "important", + "several", + "tandem", + "modular", + "units", + "enzymes", + "architecture", + "highly", + "small", "compact", + "termini", + "duplication", + "computational", + "peptide", + "molecule", + "local", + "c", + "design", "diverse", - "overall", - "closed", - "construction", + "natural", + "simple", + "hence", + "yet", + "produce", + "assembly", "n", - "novo", "driven", - "purely", - "repetition", - "modular", - "folds", + "template", + "seen", + "architectures", + "juxtapose", + "amino", + "diversification", "validated", - "domains", + "series", + "applied", + "sequence", + "building", + "present", + "recombination", + "materials", + "validation", + "folds", + "catalysis", + "designed", "partners", - "binding", - "protein", - "termini", - "previous", - "knowledge", - "development", - "computational", + "example", + "sequences", "unlike", + "geometry", + "structures", + "de", + "ranging", + "suitable", + "approaches", + "without", + "structure", + "important", + "dictated", + "rely", + "report", + "crystallography", + "nature", "internal", - "formed" + "scaffolding", + "conformations", + "existing", + "database", + "fibrous" ], "release_date":"2015-12-16", "publication":"\"Rational design of alpha-helical tandem repeat proteins with closed architectures\", Nature, 528, 585-588", @@ -127420,114 +127710,114 @@ ], "subtitle":"Crystal structure of a designed mn binding peptide", "tags":[ - "manganese cofactors", "de novo protein", - "mn4ca cluster" + "mn4ca cluster", + "manganese cofactors" ], "keywords":[ - "part", - "anderson", - "ronald", - "architecture", + "engineering", + "constrained", + "additional", "multiple", + "combining", + "three", "details", - "electronic", - "issue", - "metal", - "cluster", - "crystallography", - "bacteriochlorophyll", + "ligands", "cofactors", - "optical", - "modeling", - "determined", - "target", - "features", - "ii", - "added", - "bind", - "opportunity", - "structure", + "model", + "protein", + "inhomogeneous", + "electron", + "bacterial", + "showed", + "coordination", + "confirmed", "networks", + "centers", + "ronald", + "mn4ca", + "anderson", + "two", + "secondary", + "binds", + "special", + "edited", + "using", + "added", + "complex", + "reaction", + "photosystem", + "donor", + "metal", + "bundles", "able", - "novel", "bioenergetics", - "combining", - "proteins", - "coordination", - "investigated", + "dimer", "influence", - "binds", - "mononuclear", - "constrained", - "inhomogeneous", - "centers", - "effective", - "center", - "natural", - "three", - "showed", - "concerning", - "native", - "alternatively", - "revealed", - "likely", - "entitled", - "ligands", - "additional", - "investigate", - "special", + "donate", "incorporated", + "electronic", + "environments", + "bind", + "proteins", + "part", + "cytochrome", "mn", - "mn4ca", - "resulted", - "bundles", - "article", - "artificial", - "dimer", - "transfer", - "engineering", - "provides", - "design", - "model", - "donor", - "using", - "secondary", - "surface", - "formation", + "architecture", + "center", + "entitled", + "features", "c2", - "multinuclear", "biodesign", - "designs", - "ross", - "bacterial", - "one", - "exogenous", - "koder", - "cofactor", - "modified", + "investigate", + "surface", + "effective", + "design", "similarly", - "experiments", - "electron", "spectroscopy", - "confirmed", - "reaction", - "donate", - "two", - "environments", - "cytochrome", - "state", - "addition", - "protein", - "complex", + "provides", + "natural", "dinuclear", - "periplasmic", + "addition", + "experiments", + "resulted", + "formation", "docked", - "edited", "compelling", + "modeling", + "cofactor", + "optical", + "article", + "revealed", + "multinuclear", + "one", + "investigated", + "periplasmic", "oxidized", - "photosystem", - "create" + "concerning", + "issue", + "likely", + "structure", + "determined", + "bacteriochlorophyll", + "target", + "crystallography", + "state", + "exogenous", + "koder", + "cluster", + "artificial", + "modified", + "native", + "alternatively", + "ross", + "mononuclear", + "create", + "designs", + "opportunity", + "transfer", + "novel", + "ii" ], "release_date":"2015-10-21", "publication":"\"Design of dinuclear manganese cofactors for bacterial reaction centers\", Biochim.Biophys.Acta, 1857, 539-547", @@ -127560,7 +127850,7 @@ "seq_thr_sim_designed":[ { "sim":66.0, - "partner":"8d9o" + "partner":"5vjs" }, { "sim":66.0, @@ -127568,11 +127858,11 @@ }, { "sim":66.0, - "partner":"8d9p" + "partner":"8d9o" }, { "sim":66.0, - "partner":"5vjs" + "partner":"8d9p" }, { "sim":63.0, @@ -127582,11 +127872,11 @@ "seq_thr_sim_natural":[ { "sim":99.0, - "partner":"1u7m" + "partner":"1mft" }, { "sim":99.0, - "partner":"1mft" + "partner":"1u7m" }, { "sim":80.0, @@ -127616,11 +127906,11 @@ ], "seq_max_sim_designed":{ "sim":66.0, - "partner":"8d9o" + "partner":"5vjs" }, "seq_max_sim_natural":{ "sim":99.0, - "partner":"1u7m" + "partner":"1mft" }, "struct_max_sim_designed":{ "sim":0.9149000049, @@ -127678,76 +127968,76 @@ ], "subtitle":"Crystal structure of nvpizza2-s16h58 coordinating a cdcl2 nanocrystal", "tags":[ - "cadmium", - "biomineralization", - "metalloproteins", - "computational protein design", "symmetrical protein", + "nano-crystal", "de novo protein", - "nano-crystal" + "cadmium", + "computational protein design", + "biomineralization", + "metalloproteins" ], "keywords":[ - "variant", - "seven", - "containing", - "analysis", - "reported", - "per", - "chain", - "results", - "proteins", - "reveals", - "carries", - "lies", - "nanocrystals", - "date", - "single", - "cadmium", "trimer", - "metal", - "ions", - "plane", - "twelve", - "sandwiched", - "artificial", - "smallest", "designed", - "together", - "trimers", - "properties", - "presence", + "analysis", "engineered", - "copies", - "useful", - "feasibility", - "two", - "domains", - "bonding", + "symmetry", + "metal", + "twelve", + "cadmium", + "indicate", + "chain", + "nearly", + "single", + "pizza", + "associate", "chloride", - "crystallographic", + "rationally", + "nanocrystals", + "presence", + "properties", + "variant", "polypeptide", + "carries", + "new", + "copies", + "trimers", + "results", "symmetrical", - "binding", + "ion", "protein", - "rationally", - "using", - "biomineralize", - "identical", - "pizza", - "interspersed", - "symmetry", - "solution", - "nanocrystal", "lying", - "indicate", + "nanocrystal", + "plane", "axis", - "nearly", - "novel", + "useful", + "proteins", + "binding", + "lies", + "solution", + "artificial", + "ions", + "feasibility", + "together", "site", + "sandwiched", + "domains", + "interspersed", + "date", + "reported", + "reveals", + "seven", "forms", - "associate", - "ion", - "new" + "identical", + "two", + "biomineralize", + "crystallographic", + "containing", + "using", + "per", + "novel", + "smallest", + "bonding" ], "release_date":"2015-07-22", "publication":"\"Biomineralization of a Cadmium Chloride Nanocrystal by a Designed Symmetrical Protein\", Angew.Chem.Int.Ed.Engl., 54, 9857-9860", @@ -127788,23 +128078,23 @@ }, { "sim":171.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":171.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":168.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":168.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":168.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":168.0, @@ -127816,19 +128106,19 @@ }, { "sim":164.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":164.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":164.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":164.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":164.0, @@ -127836,11 +128126,11 @@ }, { "sim":164.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":164.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":164.0, @@ -127848,7 +128138,7 @@ }, { "sim":164.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":163.0, @@ -127860,23 +128150,23 @@ }, { "sim":161.0, - "partner":"7zcj" + "partner":"7zq2" }, { "sim":161.0, - "partner":"7zq2" + "partner":"7zqg" }, { "sim":161.0, - "partner":"7zqg" + "partner":"7zcj" }, { "sim":160.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":160.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":160.0, @@ -127884,7 +128174,7 @@ }, { "sim":160.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":159.0, @@ -127904,11 +128194,11 @@ }, { "sim":158.0, - "partner":"6i3a" + "partner":"6i39" }, { "sim":158.0, - "partner":"6i39" + "partner":"6i3a" }, { "sim":158.0, @@ -127922,11 +128212,11 @@ "seq_thr_sim_natural":[ { "sim":123.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":123.0, - "partner":"1rwi" + "partner":"1rwl" } ], "struct_thr_sim_designed":[ @@ -128028,7 +128318,7 @@ }, "seq_max_sim_natural":{ "sim":123.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9815999866, @@ -128108,74 +128398,74 @@ "subtitle":"Crystal structure of de novo designed ferredoxin-ferredoxin domain insertion protein", "tags":[ "designed", - "de novo protein", "de novo", - "domain insertion", - "ferredoxin" + "de novo protein", + "ferredoxin", + "domain insertion" ], "keywords":[ - "interfaces", - "containing", - "domain", - "demonstrate", - "evolution", - "poses", - "designs", + "designed", + "form", + "complex", + "alternative", + "models", + "limited", + "design", + "beta", "one", - "matches", + "interfaces", "another", - "amino", - "models", - "large", - "newly", + "number", + "formed", + "fusion", + "poses", "merged", - "presumably", - "similar", - "extended", + "structures", "de", - "novo", "single", - "challenge", + "natural", + "domain", + "different", + "newly", + "extended", + "acid", "sheet", - "connectivities", + "matches", + "insertion", + "closely", + "protein", + "followed", "topologies", - "acid", + "six", + "amino", "optimization", - "designed", - "number", - "emergence", + "yield", + "large", + "packing", + "searches", + "sheets", + "contributed", "may", - "different", - "closely", + "novo", + "scop", + "demonstrate", + "sequence", + "match", + "emergence", "two", + "evolution", "crystal", + "database", + "weak", "arrangements", - "six", - "limited", - "match", - "design", - "sheets", "mechanism", - "followed", - "structures", - "protein", - "yield", - "weak", - "complex", - "searches", - "insertion", - "natural", - "sequence", - "fusion", - "beta", + "challenge", + "designs", + "containing", + "presumably", "computational", - "form", - "contributed", - "database", - "alternative", - "packing", - "scop", - "formed" + "connectivities", + "similar" ], "release_date":"2015-09-23", "publication":"\"Precise assembly of complex beta sheet topologies from de novo designed building blocks\", Elife, 4", @@ -128216,15 +128506,15 @@ }, { "sim":126.0, - "partner":"4nez" + "partner":"4kyz" }, { "sim":126.0, - "partner":"4kyz" + "partner":"4ky3" }, { "sim":126.0, - "partner":"4ky3" + "partner":"4nez" }, { "sim":126.0, @@ -128348,99 +128638,99 @@ "helical repeat protein" ], "keywords":[ - "evolution", - "monomeric", - "results", - "multiple", - "possibilities", - "use", - "scattering", - "close", - "53", - "roles", - "scaffolding", - "geometries", - "generated", - "broad", - "experimentally", - "crystal", - "show", - "sequences", - "repeating", - "structure", + "engineering", + "molecular", + "recognition", + "specified", + "unrelated", + "structural", "repeat", + "show", + "multiple", + "question", "widespread", - "novel", - "consistent", - "array", - "composed", - "chain", - "proteins", - "models", - "biomolecular", - "\u00e5", - "characterized", - "square", - "processes", - "small", - "simple", - "recognition", + "roles", + "mean", + "polypeptide", + "results", + "new", + "spectra", + "root", + "protein", "motif", - "nature", - "occurring", - "folded", - "structures", - "naturally", + "close", "essential", - "solution", - "investigate", - "fraction", - "deviations", - "molecular", - "specified", - "spectra", - "extent", - "ranging", + "composed", + "applications", + "crystal", + "stable", + "occurring", "occupy", - "opening", - "tandem", + "characterized", + "signalling", "agreement", - "engineering", - "unit", - "design", - "spanning", - "polypeptide", - "applications", - "existing", - "sequence", + "experimentally", "biological", - "root", - "known", - "structural", - "range", - "sample", - "question", - "designs", - "critical", "accessible", - "stable", - "wide", - "95", + "folded", + "proteins", + "broad", + "use", + "scattering", + "tandem", "modular", - "copies", - "unrelated", + "small", + "possibilities", + "extent", + "evolution", + "15", + "square", + "computational", + "investigate", + "geometries", + "critical", + "design", + "chain", + "simple", + "possible", + "processes", "precisely", + "biomolecular", + "wide", + "solution", + "sequence", + "range", "central", - "protein", - "15", - "signalling", + "models", + "naturally", + "sequences", + "array", "space", - "mean", + "repeating", + "opening", + "structures", + "ranging", + "95", + "\u00e5", + "structure", + "monomeric", + "deviations", + "copies", "43", - "computational", - "possible", + "spanning", + "nature", "curvatures", - "new" + "53", + "known", + "unit", + "fraction", + "generated", + "sample", + "scaffolding", + "existing", + "designs", + "novel", + "consistent" ], "release_date":"2015-12-16", "publication":"\"Exploring the repeat protein universe through computational protein design\", Nature, 528, 580-584", @@ -128581,99 +128871,99 @@ "helical repeat protein" ], "keywords":[ - "evolution", - "monomeric", - "results", - "multiple", - "possibilities", - "use", - "scattering", - "close", - "53", - "roles", - "scaffolding", - "geometries", - "generated", - "broad", - "experimentally", - "crystal", - "show", - "sequences", - "repeating", - "structure", + "engineering", + "molecular", + "recognition", + "specified", + "unrelated", + "structural", "repeat", + "show", + "multiple", + "question", "widespread", - "novel", - "consistent", - "array", - "composed", - "chain", - "proteins", - "models", - "biomolecular", - "\u00e5", - "characterized", - "square", - "processes", - "small", - "simple", - "recognition", + "roles", + "mean", + "polypeptide", + "results", + "new", + "spectra", + "root", + "protein", "motif", - "nature", - "occurring", - "folded", - "structures", - "naturally", + "close", "essential", - "solution", - "investigate", - "fraction", - "deviations", - "molecular", - "specified", - "spectra", - "extent", - "ranging", + "composed", + "applications", + "crystal", + "stable", + "occurring", "occupy", - "opening", - "tandem", + "characterized", + "signalling", "agreement", - "engineering", - "unit", - "design", - "spanning", - "polypeptide", - "applications", - "existing", - "sequence", + "experimentally", "biological", - "root", - "known", - "structural", - "range", - "sample", - "question", - "designs", - "critical", "accessible", - "stable", - "wide", - "95", + "folded", + "proteins", + "broad", + "use", + "scattering", + "tandem", "modular", - "copies", - "unrelated", + "small", + "possibilities", + "extent", + "evolution", + "15", + "square", + "computational", + "investigate", + "geometries", + "critical", + "design", + "chain", + "simple", + "possible", + "processes", "precisely", + "biomolecular", + "wide", + "solution", + "sequence", + "range", "central", - "protein", - "15", - "signalling", + "models", + "naturally", + "sequences", + "array", "space", - "mean", + "repeating", + "opening", + "structures", + "ranging", + "95", + "\u00e5", + "structure", + "monomeric", + "deviations", + "copies", "43", - "computational", - "possible", + "spanning", + "nature", "curvatures", - "new" + "53", + "known", + "unit", + "fraction", + "generated", + "sample", + "scaffolding", + "existing", + "designs", + "novel", + "consistent" ], "release_date":"2015-12-16", "publication":"\"Exploring the repeat protein universe through computational protein design\", Nature, 528, 580-584", @@ -128821,99 +129111,99 @@ "helical repeat protein" ], "keywords":[ - "evolution", - "monomeric", - "results", - "multiple", - "possibilities", - "use", - "scattering", - "close", - "53", - "roles", - "scaffolding", - "geometries", - "generated", - "broad", - "experimentally", - "crystal", - "show", - "sequences", - "repeating", - "structure", + "engineering", + "molecular", + "recognition", + "specified", + "unrelated", + "structural", "repeat", + "show", + "multiple", + "question", "widespread", - "novel", - "consistent", - "array", - "composed", - "chain", - "proteins", - "models", - "biomolecular", - "\u00e5", - "characterized", - "square", - "processes", - "small", - "simple", - "recognition", + "roles", + "mean", + "polypeptide", + "results", + "new", + "spectra", + "root", + "protein", "motif", - "nature", - "occurring", - "folded", - "structures", - "naturally", + "close", "essential", - "solution", - "investigate", - "fraction", - "deviations", - "molecular", - "specified", - "spectra", - "extent", - "ranging", + "composed", + "applications", + "crystal", + "stable", + "occurring", "occupy", - "opening", - "tandem", + "characterized", + "signalling", "agreement", - "engineering", - "unit", - "design", - "spanning", - "polypeptide", - "applications", - "existing", - "sequence", + "experimentally", "biological", - "root", - "known", - "structural", - "range", - "sample", - "question", - "designs", - "critical", "accessible", - "stable", - "wide", - "95", + "folded", + "proteins", + "broad", + "use", + "scattering", + "tandem", "modular", - "copies", - "unrelated", + "small", + "possibilities", + "extent", + "evolution", + "15", + "square", + "computational", + "investigate", + "geometries", + "critical", + "design", + "chain", + "simple", + "possible", + "processes", "precisely", + "biomolecular", + "wide", + "solution", + "sequence", + "range", "central", - "protein", - "15", - "signalling", + "models", + "naturally", + "sequences", + "array", "space", - "mean", + "repeating", + "opening", + "structures", + "ranging", + "95", + "\u00e5", + "structure", + "monomeric", + "deviations", + "copies", "43", - "computational", - "possible", + "spanning", + "nature", "curvatures", - "new" + "53", + "known", + "unit", + "fraction", + "generated", + "sample", + "scaffolding", + "existing", + "designs", + "novel", + "consistent" ], "release_date":"2015-12-16", "publication":"\"Exploring the repeat protein universe through computational protein design\", Nature, 528, 580-584", @@ -129046,99 +129336,99 @@ "helical repeat protein" ], "keywords":[ - "evolution", - "monomeric", - "results", - "multiple", - "possibilities", - "use", - "scattering", - "close", - "53", - "roles", - "scaffolding", - "geometries", - "generated", - "broad", - "experimentally", - "crystal", - "show", - "sequences", - "repeating", - "structure", + "engineering", + "molecular", + "recognition", + "specified", + "unrelated", + "structural", "repeat", + "show", + "multiple", + "question", "widespread", - "novel", - "consistent", - "array", - "composed", - "chain", - "proteins", - "models", - "biomolecular", - "\u00e5", - "characterized", - "square", - "processes", - "small", - "simple", - "recognition", + "roles", + "mean", + "polypeptide", + "results", + "new", + "spectra", + "root", + "protein", "motif", - "nature", - "occurring", - "folded", - "structures", - "naturally", + "close", "essential", - "solution", - "investigate", - "fraction", - "deviations", - "molecular", - "specified", - "spectra", - "extent", - "ranging", + "composed", + "applications", + "crystal", + "stable", + "occurring", "occupy", - "opening", - "tandem", + "characterized", + "signalling", "agreement", - "engineering", - "unit", - "design", - "spanning", - "polypeptide", - "applications", - "existing", - "sequence", + "experimentally", "biological", - "root", - "known", - "structural", - "range", - "sample", - "question", - "designs", - "critical", "accessible", - "stable", - "wide", - "95", + "folded", + "proteins", + "broad", + "use", + "scattering", + "tandem", "modular", - "copies", - "unrelated", + "small", + "possibilities", + "extent", + "evolution", + "15", + "square", + "computational", + "investigate", + "geometries", + "critical", + "design", + "chain", + "simple", + "possible", + "processes", "precisely", + "biomolecular", + "wide", + "solution", + "sequence", + "range", "central", - "protein", - "15", - "signalling", + "models", + "naturally", + "sequences", + "array", "space", - "mean", + "repeating", + "opening", + "structures", + "ranging", + "95", + "\u00e5", + "structure", + "monomeric", + "deviations", + "copies", "43", - "computational", - "possible", + "spanning", + "nature", "curvatures", - "new" + "53", + "known", + "unit", + "fraction", + "generated", + "sample", + "scaffolding", + "existing", + "designs", + "novel", + "consistent" ], "release_date":"2015-12-16", "publication":"\"Exploring the repeat protein universe through computational protein design\", Nature, 528, 580-584", @@ -129271,99 +129561,99 @@ "helical repeat protein" ], "keywords":[ - "evolution", - "monomeric", - "results", - "multiple", - "possibilities", - "use", - "scattering", - "close", - "53", - "roles", - "scaffolding", - "geometries", - "generated", - "broad", - "experimentally", - "crystal", - "show", - "sequences", - "repeating", - "structure", + "engineering", + "molecular", + "recognition", + "specified", + "unrelated", + "structural", "repeat", + "show", + "multiple", + "question", "widespread", - "novel", - "consistent", - "array", - "composed", - "chain", - "proteins", - "models", - "biomolecular", - "\u00e5", - "characterized", - "square", - "processes", - "small", - "simple", - "recognition", + "roles", + "mean", + "polypeptide", + "results", + "new", + "spectra", + "root", + "protein", "motif", - "nature", - "occurring", - "folded", - "structures", - "naturally", + "close", "essential", - "solution", - "investigate", - "fraction", - "deviations", - "molecular", - "specified", - "spectra", - "extent", - "ranging", + "composed", + "applications", + "crystal", + "stable", + "occurring", "occupy", - "opening", - "tandem", + "characterized", + "signalling", "agreement", - "engineering", - "unit", - "design", - "spanning", - "polypeptide", - "applications", - "existing", - "sequence", + "experimentally", "biological", - "root", - "known", - "structural", - "range", - "sample", - "question", - "designs", - "critical", "accessible", - "stable", - "wide", - "95", + "folded", + "proteins", + "broad", + "use", + "scattering", + "tandem", "modular", - "copies", - "unrelated", + "small", + "possibilities", + "extent", + "evolution", + "15", + "square", + "computational", + "investigate", + "geometries", + "critical", + "design", + "chain", + "simple", + "possible", + "processes", "precisely", + "biomolecular", + "wide", + "solution", + "sequence", + "range", "central", - "protein", - "15", - "signalling", + "models", + "naturally", + "sequences", + "array", "space", - "mean", + "repeating", + "opening", + "structures", + "ranging", + "95", + "\u00e5", + "structure", + "monomeric", + "deviations", + "copies", "43", - "computational", - "possible", + "spanning", + "nature", "curvatures", - "new" + "53", + "known", + "unit", + "fraction", + "generated", + "sample", + "scaffolding", + "existing", + "designs", + "novel", + "consistent" ], "release_date":"2015-12-16", "publication":"\"Exploring the repeat protein universe through computational protein design\", Nature, 528, 580-584", @@ -129515,99 +129805,99 @@ "helical repeat protein" ], "keywords":[ - "evolution", - "monomeric", - "results", - "multiple", - "possibilities", - "use", - "scattering", - "close", - "53", - "roles", - "scaffolding", - "geometries", - "generated", - "broad", - "experimentally", - "crystal", - "show", - "sequences", - "repeating", - "structure", + "engineering", + "molecular", + "recognition", + "specified", + "unrelated", + "structural", "repeat", + "show", + "multiple", + "question", "widespread", - "novel", - "consistent", - "array", - "composed", - "chain", - "proteins", - "models", - "biomolecular", - "\u00e5", - "characterized", - "square", - "processes", - "small", - "simple", - "recognition", + "roles", + "mean", + "polypeptide", + "results", + "new", + "spectra", + "root", + "protein", "motif", - "nature", - "occurring", - "folded", - "structures", - "naturally", + "close", "essential", - "solution", - "investigate", - "fraction", - "deviations", - "molecular", - "specified", - "spectra", - "extent", - "ranging", + "composed", + "applications", + "crystal", + "stable", + "occurring", "occupy", - "opening", - "tandem", + "characterized", + "signalling", "agreement", - "engineering", - "unit", - "design", - "spanning", - "polypeptide", - "applications", - "existing", - "sequence", + "experimentally", "biological", - "root", - "known", - "structural", - "range", - "sample", - "question", - "designs", - "critical", "accessible", - "stable", - "wide", - "95", + "folded", + "proteins", + "broad", + "use", + "scattering", + "tandem", "modular", - "copies", - "unrelated", + "small", + "possibilities", + "extent", + "evolution", + "15", + "square", + "computational", + "investigate", + "geometries", + "critical", + "design", + "chain", + "simple", + "possible", + "processes", "precisely", + "biomolecular", + "wide", + "solution", + "sequence", + "range", "central", - "protein", - "15", - "signalling", + "models", + "naturally", + "sequences", + "array", "space", - "mean", + "repeating", + "opening", + "structures", + "ranging", + "95", + "\u00e5", + "structure", + "monomeric", + "deviations", + "copies", "43", - "computational", - "possible", + "spanning", + "nature", "curvatures", - "new" + "53", + "known", + "unit", + "fraction", + "generated", + "sample", + "scaffolding", + "existing", + "designs", + "novel", + "consistent" ], "release_date":"2015-12-16", "publication":"\"Exploring the repeat protein universe through computational protein design\", Nature, 528, 580-584", @@ -129740,99 +130030,99 @@ "helical repeat protein" ], "keywords":[ - "evolution", - "monomeric", - "results", - "multiple", - "possibilities", - "use", - "scattering", - "close", - "53", - "roles", - "scaffolding", - "geometries", - "generated", - "broad", - "experimentally", - "crystal", - "show", - "sequences", - "repeating", - "structure", + "engineering", + "molecular", + "recognition", + "specified", + "unrelated", + "structural", "repeat", + "show", + "multiple", + "question", "widespread", - "novel", - "consistent", - "array", - "composed", - "chain", - "proteins", - "models", - "biomolecular", - "\u00e5", - "characterized", - "square", - "processes", - "small", - "simple", - "recognition", + "roles", + "mean", + "polypeptide", + "results", + "new", + "spectra", + "root", + "protein", "motif", - "nature", - "occurring", - "folded", - "structures", - "naturally", + "close", "essential", - "solution", - "investigate", - "fraction", - "deviations", - "molecular", - "specified", - "spectra", - "extent", - "ranging", + "composed", + "applications", + "crystal", + "stable", + "occurring", "occupy", - "opening", - "tandem", + "characterized", + "signalling", "agreement", - "engineering", - "unit", - "design", - "spanning", - "polypeptide", - "applications", - "existing", - "sequence", + "experimentally", "biological", - "root", - "known", - "structural", - "range", - "sample", - "question", - "designs", - "critical", "accessible", - "stable", - "wide", - "95", + "folded", + "proteins", + "broad", + "use", + "scattering", + "tandem", "modular", - "copies", - "unrelated", + "small", + "possibilities", + "extent", + "evolution", + "15", + "square", + "computational", + "investigate", + "geometries", + "critical", + "design", + "chain", + "simple", + "possible", + "processes", "precisely", + "biomolecular", + "wide", + "solution", + "sequence", + "range", "central", - "protein", - "15", - "signalling", + "models", + "naturally", + "sequences", + "array", "space", - "mean", + "repeating", + "opening", + "structures", + "ranging", + "95", + "\u00e5", + "structure", + "monomeric", + "deviations", + "copies", "43", - "computational", - "possible", + "spanning", + "nature", "curvatures", - "new" + "53", + "known", + "unit", + "fraction", + "generated", + "sample", + "scaffolding", + "existing", + "designs", + "novel", + "consistent" ], "release_date":"2015-12-16", "publication":"\"Exploring the repeat protein universe through computational protein design\", Nature, 528, 580-584", @@ -129961,99 +130251,99 @@ "helical repeat protein" ], "keywords":[ - "evolution", - "monomeric", - "results", - "multiple", - "possibilities", - "use", - "scattering", - "close", - "53", - "roles", - "scaffolding", - "geometries", - "generated", - "broad", - "experimentally", - "crystal", - "show", - "sequences", - "repeating", - "structure", + "engineering", + "molecular", + "recognition", + "specified", + "unrelated", + "structural", "repeat", + "show", + "multiple", + "question", "widespread", - "novel", - "consistent", - "array", - "composed", - "chain", - "proteins", - "models", - "biomolecular", - "\u00e5", - "characterized", - "square", - "processes", - "small", - "simple", - "recognition", + "roles", + "mean", + "polypeptide", + "results", + "new", + "spectra", + "root", + "protein", "motif", - "nature", - "occurring", - "folded", - "structures", - "naturally", + "close", "essential", - "solution", - "investigate", - "fraction", - "deviations", - "molecular", - "specified", - "spectra", - "extent", - "ranging", + "composed", + "applications", + "crystal", + "stable", + "occurring", "occupy", - "opening", - "tandem", + "characterized", + "signalling", "agreement", - "engineering", - "unit", - "design", - "spanning", - "polypeptide", - "applications", - "existing", - "sequence", + "experimentally", "biological", - "root", - "known", - "structural", - "range", - "sample", - "question", - "designs", - "critical", "accessible", - "stable", - "wide", - "95", + "folded", + "proteins", + "broad", + "use", + "scattering", + "tandem", "modular", - "copies", - "unrelated", + "small", + "possibilities", + "extent", + "evolution", + "15", + "square", + "computational", + "investigate", + "geometries", + "critical", + "design", + "chain", + "simple", + "possible", + "processes", "precisely", + "biomolecular", + "wide", + "solution", + "sequence", + "range", "central", - "protein", - "15", - "signalling", + "models", + "naturally", + "sequences", + "array", "space", - "mean", + "repeating", + "opening", + "structures", + "ranging", + "95", + "\u00e5", + "structure", + "monomeric", + "deviations", + "copies", "43", - "computational", - "possible", + "spanning", + "nature", "curvatures", - "new" + "53", + "known", + "unit", + "fraction", + "generated", + "sample", + "scaffolding", + "existing", + "designs", + "novel", + "consistent" ], "release_date":"2015-12-16", "publication":"\"Exploring the repeat protein universe through computational protein design\", Nature, 528, 580-584", @@ -130194,99 +130484,99 @@ "helical repeat protein" ], "keywords":[ - "evolution", - "monomeric", - "results", - "multiple", - "possibilities", - "use", - "scattering", - "close", - "53", - "roles", - "scaffolding", - "geometries", - "generated", - "broad", - "experimentally", - "crystal", - "show", - "sequences", - "repeating", - "structure", + "engineering", + "molecular", + "recognition", + "specified", + "unrelated", + "structural", "repeat", + "show", + "multiple", + "question", "widespread", - "novel", - "consistent", - "array", + "roles", + "mean", + "polypeptide", + "results", + "new", + "spectra", + "root", + "protein", + "motif", + "close", + "essential", "composed", - "chain", - "proteins", - "models", - "biomolecular", - "\u00e5", + "applications", + "crystal", + "stable", + "occurring", + "occupy", "characterized", - "square", - "processes", - "small", - "simple", - "recognition", - "motif", - "nature", - "occurring", - "folded", - "structures", - "naturally", - "essential", - "solution", - "investigate", - "fraction", - "deviations", - "molecular", - "specified", - "spectra", - "extent", - "ranging", - "occupy", - "opening", - "tandem", + "signalling", "agreement", - "engineering", - "unit", - "design", - "spanning", - "polypeptide", - "applications", - "existing", - "sequence", + "experimentally", "biological", - "root", - "known", - "structural", - "range", - "sample", - "question", - "designs", - "critical", "accessible", - "stable", - "wide", - "95", + "folded", + "proteins", + "broad", + "use", + "scattering", + "tandem", "modular", - "copies", - "unrelated", + "small", + "possibilities", + "extent", + "evolution", + "15", + "square", + "computational", + "investigate", + "geometries", + "critical", + "design", + "chain", + "simple", + "possible", + "processes", "precisely", + "biomolecular", + "wide", + "solution", + "sequence", + "range", "central", - "protein", - "15", - "signalling", + "models", + "naturally", + "sequences", + "array", "space", - "mean", + "repeating", + "opening", + "structures", + "ranging", + "95", + "\u00e5", + "structure", + "monomeric", + "deviations", + "copies", "43", - "computational", - "possible", + "spanning", + "nature", "curvatures", - "new" + "53", + "known", + "unit", + "fraction", + "generated", + "sample", + "scaffolding", + "existing", + "designs", + "novel", + "consistent" ], "release_date":"2015-12-16", "publication":"\"Exploring the repeat protein universe through computational protein design\", Nature, 528, 580-584", @@ -130427,99 +130717,99 @@ "helical repeat protein" ], "keywords":[ - "evolution", - "monomeric", - "results", - "multiple", - "possibilities", - "use", - "scattering", - "close", - "53", - "roles", - "scaffolding", - "geometries", - "generated", - "broad", - "experimentally", - "crystal", - "show", - "sequences", - "repeating", - "structure", + "engineering", + "molecular", + "recognition", + "specified", + "unrelated", + "structural", "repeat", + "show", + "multiple", + "question", "widespread", - "novel", - "consistent", - "array", - "composed", - "chain", - "proteins", - "models", - "biomolecular", - "\u00e5", - "characterized", - "square", - "processes", - "small", - "simple", - "recognition", + "roles", + "mean", + "polypeptide", + "results", + "new", + "spectra", + "root", + "protein", "motif", - "nature", - "occurring", - "folded", - "structures", - "naturally", + "close", "essential", - "solution", - "investigate", - "fraction", - "deviations", - "molecular", - "specified", - "spectra", - "extent", - "ranging", + "composed", + "applications", + "crystal", + "stable", + "occurring", "occupy", - "opening", - "tandem", + "characterized", + "signalling", "agreement", - "engineering", - "unit", - "design", - "spanning", - "polypeptide", - "applications", - "existing", - "sequence", + "experimentally", "biological", - "root", - "known", - "structural", - "range", - "sample", - "question", - "designs", - "critical", "accessible", - "stable", - "wide", - "95", + "folded", + "proteins", + "broad", + "use", + "scattering", + "tandem", "modular", - "copies", - "unrelated", + "small", + "possibilities", + "extent", + "evolution", + "15", + "square", + "computational", + "investigate", + "geometries", + "critical", + "design", + "chain", + "simple", + "possible", + "processes", "precisely", + "biomolecular", + "wide", + "solution", + "sequence", + "range", "central", - "protein", - "15", - "signalling", + "models", + "naturally", + "sequences", + "array", "space", - "mean", + "repeating", + "opening", + "structures", + "ranging", + "95", + "\u00e5", + "structure", + "monomeric", + "deviations", + "copies", "43", - "computational", - "possible", + "spanning", + "nature", "curvatures", - "new" + "53", + "known", + "unit", + "fraction", + "generated", + "sample", + "scaffolding", + "existing", + "designs", + "novel", + "consistent" ], "release_date":"2015-12-16", "publication":"\"Exploring the repeat protein universe through computational protein design\", Nature, 528, 580-584", @@ -130688,99 +130978,99 @@ "helical repeat protein" ], "keywords":[ - "evolution", - "monomeric", - "results", - "multiple", - "possibilities", - "use", - "scattering", - "close", - "53", - "roles", - "scaffolding", - "geometries", - "generated", - "broad", - "experimentally", - "crystal", - "show", - "sequences", - "repeating", - "structure", + "engineering", + "molecular", + "recognition", + "specified", + "unrelated", + "structural", "repeat", + "show", + "multiple", + "question", "widespread", - "novel", - "consistent", - "array", - "composed", - "chain", - "proteins", - "models", - "biomolecular", - "\u00e5", - "characterized", - "square", - "processes", - "small", - "simple", - "recognition", + "roles", + "mean", + "polypeptide", + "results", + "new", + "spectra", + "root", + "protein", "motif", - "nature", - "occurring", - "folded", - "structures", - "naturally", + "close", "essential", - "solution", - "investigate", - "fraction", - "deviations", - "molecular", - "specified", - "spectra", - "extent", - "ranging", + "composed", + "applications", + "crystal", + "stable", + "occurring", "occupy", - "opening", - "tandem", + "characterized", + "signalling", "agreement", - "engineering", - "unit", - "design", - "spanning", - "polypeptide", - "applications", - "existing", - "sequence", + "experimentally", "biological", - "root", - "known", - "structural", - "range", - "sample", - "question", - "designs", - "critical", "accessible", - "stable", - "wide", - "95", + "folded", + "proteins", + "broad", + "use", + "scattering", + "tandem", "modular", - "copies", - "unrelated", + "small", + "possibilities", + "extent", + "evolution", + "15", + "square", + "computational", + "investigate", + "geometries", + "critical", + "design", + "chain", + "simple", + "possible", + "processes", "precisely", + "biomolecular", + "wide", + "solution", + "sequence", + "range", "central", - "protein", - "15", - "signalling", + "models", + "naturally", + "sequences", + "array", "space", - "mean", + "repeating", + "opening", + "structures", + "ranging", + "95", + "\u00e5", + "structure", + "monomeric", + "deviations", + "copies", "43", - "computational", - "possible", + "spanning", + "nature", "curvatures", - "new" + "53", + "known", + "unit", + "fraction", + "generated", + "sample", + "scaffolding", + "existing", + "designs", + "novel", + "consistent" ], "release_date":"2015-12-16", "publication":"\"Exploring the repeat protein universe through computational protein design\", Nature, 528, 580-584", @@ -130923,6 +131213,10 @@ "sim":65.0, "partner":"8e1e" }, + { + "sim":55.0, + "partner":"8vea" + }, { "sim":52.0, "partner":"8utm" @@ -131025,99 +131319,99 @@ "helical repeat protein" ], "keywords":[ - "evolution", - "monomeric", - "results", - "multiple", - "possibilities", - "use", - "scattering", - "close", - "53", - "roles", - "scaffolding", - "geometries", - "generated", - "broad", - "experimentally", - "crystal", - "show", - "sequences", - "repeating", - "structure", + "engineering", + "molecular", + "recognition", + "specified", + "unrelated", + "structural", "repeat", + "show", + "multiple", + "question", "widespread", - "novel", - "consistent", - "array", - "composed", - "chain", - "proteins", - "models", - "biomolecular", - "\u00e5", - "characterized", - "square", - "processes", - "small", - "simple", - "recognition", + "roles", + "mean", + "polypeptide", + "results", + "new", + "spectra", + "root", + "protein", "motif", - "nature", - "occurring", - "folded", - "structures", - "naturally", + "close", "essential", - "solution", - "investigate", - "fraction", - "deviations", - "molecular", - "specified", - "spectra", - "extent", - "ranging", + "composed", + "applications", + "crystal", + "stable", + "occurring", "occupy", - "opening", - "tandem", + "characterized", + "signalling", "agreement", - "engineering", - "unit", - "design", - "spanning", - "polypeptide", - "applications", - "existing", - "sequence", + "experimentally", "biological", - "root", - "known", - "structural", - "range", - "sample", - "question", - "designs", - "critical", "accessible", - "stable", - "wide", - "95", + "folded", + "proteins", + "broad", + "use", + "scattering", + "tandem", "modular", - "copies", - "unrelated", + "small", + "possibilities", + "extent", + "evolution", + "15", + "square", + "computational", + "investigate", + "geometries", + "critical", + "design", + "chain", + "simple", + "possible", + "processes", "precisely", + "biomolecular", + "wide", + "solution", + "sequence", + "range", "central", - "protein", - "15", - "signalling", + "models", + "naturally", + "sequences", + "array", "space", - "mean", + "repeating", + "opening", + "structures", + "ranging", + "95", + "\u00e5", + "structure", + "monomeric", + "deviations", + "copies", "43", - "computational", - "possible", + "spanning", + "nature", "curvatures", - "new" + "53", + "known", + "unit", + "fraction", + "generated", + "sample", + "scaffolding", + "existing", + "designs", + "novel", + "consistent" ], "release_date":"2015-12-16", "publication":"\"Exploring the repeat protein universe through computational protein design\", Nature, 528, 580-584", @@ -131290,99 +131584,99 @@ "helical repeat protein" ], "keywords":[ - "evolution", - "monomeric", - "results", - "multiple", - "possibilities", - "use", - "scattering", - "close", - "53", - "roles", - "scaffolding", - "geometries", - "generated", - "broad", - "experimentally", - "crystal", - "show", - "sequences", - "repeating", - "structure", + "engineering", + "molecular", + "recognition", + "specified", + "unrelated", + "structural", "repeat", + "show", + "multiple", + "question", "widespread", - "novel", - "consistent", - "array", - "composed", - "chain", - "proteins", - "models", - "biomolecular", - "\u00e5", - "characterized", - "square", - "processes", - "small", - "simple", - "recognition", + "roles", + "mean", + "polypeptide", + "results", + "new", + "spectra", + "root", + "protein", "motif", - "nature", - "occurring", - "folded", - "structures", - "naturally", + "close", "essential", - "solution", - "investigate", - "fraction", - "deviations", - "molecular", - "specified", - "spectra", - "extent", - "ranging", + "composed", + "applications", + "crystal", + "stable", + "occurring", "occupy", - "opening", - "tandem", + "characterized", + "signalling", "agreement", - "engineering", - "unit", - "design", - "spanning", - "polypeptide", - "applications", - "existing", - "sequence", + "experimentally", "biological", - "root", - "known", - "structural", - "range", - "sample", - "question", - "designs", - "critical", "accessible", - "stable", - "wide", - "95", + "folded", + "proteins", + "broad", + "use", + "scattering", + "tandem", "modular", - "copies", - "unrelated", + "small", + "possibilities", + "extent", + "evolution", + "15", + "square", + "computational", + "investigate", + "geometries", + "critical", + "design", + "chain", + "simple", + "possible", + "processes", "precisely", + "biomolecular", + "wide", + "solution", + "sequence", + "range", "central", - "protein", - "15", - "signalling", + "models", + "naturally", + "sequences", + "array", "space", - "mean", + "repeating", + "opening", + "structures", + "ranging", + "95", + "\u00e5", + "structure", + "monomeric", + "deviations", + "copies", "43", - "computational", - "possible", + "spanning", + "nature", "curvatures", - "new" + "53", + "known", + "unit", + "fraction", + "generated", + "sample", + "scaffolding", + "existing", + "designs", + "novel", + "consistent" ], "release_date":"2015-12-16", "publication":"\"Exploring the repeat protein universe through computational protein design\", Nature, 528, 580-584", @@ -131551,99 +131845,99 @@ "helical repeat protein" ], "keywords":[ - "evolution", - "monomeric", - "results", - "multiple", - "possibilities", - "use", - "scattering", - "close", - "53", - "roles", - "scaffolding", - "geometries", - "generated", - "broad", - "experimentally", - "crystal", - "show", - "sequences", - "repeating", - "structure", + "engineering", + "molecular", + "recognition", + "specified", + "unrelated", + "structural", "repeat", + "show", + "multiple", + "question", "widespread", - "novel", - "consistent", - "array", - "composed", - "chain", - "proteins", - "models", - "biomolecular", - "\u00e5", - "characterized", - "square", - "processes", - "small", - "simple", - "recognition", + "roles", + "mean", + "polypeptide", + "results", + "new", + "spectra", + "root", + "protein", "motif", - "nature", - "occurring", - "folded", - "structures", - "naturally", + "close", "essential", - "solution", - "investigate", - "fraction", - "deviations", - "molecular", - "specified", - "spectra", - "extent", - "ranging", + "composed", + "applications", + "crystal", + "stable", + "occurring", "occupy", - "opening", - "tandem", + "characterized", + "signalling", "agreement", - "engineering", - "unit", - "design", - "spanning", - "polypeptide", - "applications", - "existing", - "sequence", + "experimentally", "biological", - "root", - "known", - "structural", - "range", - "sample", - "question", - "designs", - "critical", "accessible", - "stable", - "wide", - "95", + "folded", + "proteins", + "broad", + "use", + "scattering", + "tandem", "modular", - "copies", - "unrelated", + "small", + "possibilities", + "extent", + "evolution", + "15", + "square", + "computational", + "investigate", + "geometries", + "critical", + "design", + "chain", + "simple", + "possible", + "processes", "precisely", + "biomolecular", + "wide", + "solution", + "sequence", + "range", "central", - "protein", - "15", - "signalling", + "models", + "naturally", + "sequences", + "array", "space", - "mean", + "repeating", + "opening", + "structures", + "ranging", + "95", + "\u00e5", + "structure", + "monomeric", + "deviations", + "copies", "43", - "computational", - "possible", + "spanning", + "nature", "curvatures", - "new" + "53", + "known", + "unit", + "fraction", + "generated", + "sample", + "scaffolding", + "existing", + "designs", + "novel", + "consistent" ], "release_date":"2015-12-16", "publication":"\"Exploring the repeat protein universe through computational protein design\", Nature, 528, 580-584", @@ -131832,99 +132126,99 @@ "helical repeat protein" ], "keywords":[ - "evolution", - "monomeric", - "results", - "multiple", - "possibilities", - "use", - "scattering", - "close", - "53", - "roles", - "scaffolding", - "geometries", - "generated", - "broad", - "experimentally", - "crystal", - "show", - "sequences", - "repeating", - "structure", + "engineering", + "molecular", + "recognition", + "specified", + "unrelated", + "structural", "repeat", + "show", + "multiple", + "question", "widespread", - "novel", - "consistent", - "array", - "composed", - "chain", - "proteins", - "models", - "biomolecular", - "\u00e5", - "characterized", - "square", - "processes", - "small", - "simple", - "recognition", + "roles", + "mean", + "polypeptide", + "results", + "new", + "spectra", + "root", + "protein", "motif", - "nature", - "occurring", - "folded", - "structures", - "naturally", + "close", "essential", - "solution", - "investigate", - "fraction", - "deviations", - "molecular", - "specified", - "spectra", - "extent", - "ranging", + "composed", + "applications", + "crystal", + "stable", + "occurring", "occupy", - "opening", - "tandem", + "characterized", + "signalling", "agreement", - "engineering", - "unit", - "design", - "spanning", - "polypeptide", - "applications", - "existing", - "sequence", + "experimentally", "biological", - "root", - "known", - "structural", - "range", - "sample", - "question", - "designs", - "critical", "accessible", - "stable", - "wide", - "95", + "folded", + "proteins", + "broad", + "use", + "scattering", + "tandem", "modular", - "copies", - "unrelated", + "small", + "possibilities", + "extent", + "evolution", + "15", + "square", + "computational", + "investigate", + "geometries", + "critical", + "design", + "chain", + "simple", + "possible", + "processes", "precisely", + "biomolecular", + "wide", + "solution", + "sequence", + "range", "central", - "protein", - "15", - "signalling", + "models", + "naturally", + "sequences", + "array", "space", - "mean", + "repeating", + "opening", + "structures", + "ranging", + "95", + "\u00e5", + "structure", + "monomeric", + "deviations", + "copies", "43", - "computational", - "possible", + "spanning", + "nature", "curvatures", - "new" + "53", + "known", + "unit", + "fraction", + "generated", + "sample", + "scaffolding", + "existing", + "designs", + "novel", + "consistent" ], "release_date":"2015-12-16", "publication":"\"Exploring the repeat protein universe through computational protein design\", Nature, 528, 580-584", @@ -132085,11 +132379,11 @@ "subtitle":"Directed evolutionary changes in kemp eliminase ke07 - crystal 3 wild type", "tags":[ "de novo protein, lyase", - "kemp eliminase", - "ke07", "de novo protein", + "ke07", "directed evolution", - "lyase" + "lyase", + "kemp eliminase" ], "keywords":[ "description", @@ -132142,11 +132436,11 @@ }, { "sim":516.0, - "partner":"5d2x" + "partner":"5d2y" }, { "sim":516.0, - "partner":"5d2y" + "partner":"5d2x" }, { "sim":509.0, @@ -132260,11 +132554,11 @@ }, { "sim":144.0, - "partner":"1jvn" + "partner":"1ox5" }, { "sim":144.0, - "partner":"1ox5" + "partner":"1jvn" }, { "sim":144.0, @@ -132452,11 +132746,11 @@ "subtitle":"Directed evolutionary changes in kemp eliminase ke07 - crystal 4 wild type", "tags":[ "de novo protein, lyase", - "kemp eliminase", - "ke07", "de novo protein", + "ke07", "directed evolution", - "lyase" + "lyase", + "kemp eliminase" ], "keywords":[ "description", @@ -132509,11 +132803,11 @@ }, { "sim":516.0, - "partner":"5d2x" + "partner":"5d2y" }, { "sim":516.0, - "partner":"5d2y" + "partner":"5d2x" }, { "sim":509.0, @@ -132627,11 +132921,11 @@ }, { "sim":144.0, - "partner":"1jvn" + "partner":"1ox5" }, { "sim":144.0, - "partner":"1ox5" + "partner":"1jvn" }, { "sim":144.0, @@ -132823,11 +133117,11 @@ "subtitle":"Directed evolutionary changes in kemp eliminase ke07 - crystal 5 wild type", "tags":[ "de novo protein, lyase", - "kemp eliminase", - "ke07", "de novo protein", + "ke07", "directed evolution", - "lyase" + "lyase", + "kemp eliminase" ], "keywords":[ "description", @@ -132864,11 +133158,11 @@ "seq_thr_sim_designed":[ { "sim":527.0, - "partner":"5d2v" + "partner":"5d2t" }, { "sim":527.0, - "partner":"5d2t" + "partner":"5d2v" }, { "sim":527.0, @@ -132880,11 +133174,11 @@ }, { "sim":516.0, - "partner":"5d2x" + "partner":"5d2y" }, { "sim":516.0, - "partner":"5d2y" + "partner":"5d2x" }, { "sim":509.0, @@ -132998,11 +133292,11 @@ }, { "sim":144.0, - "partner":"1jvn" + "partner":"1ox5" }, { "sim":144.0, - "partner":"1ox5" + "partner":"1jvn" }, { "sim":144.0, @@ -133139,7 +133433,7 @@ ], "seq_max_sim_designed":{ "sim":527.0, - "partner":"5d2v" + "partner":"5d2t" }, "seq_max_sim_natural":{ "sim":508.0, @@ -133194,11 +133488,11 @@ "subtitle":"Directed evolutionary changes in kemp eliminase ke07 - crystal 6 round5", "tags":[ "de novo protein, lyase", - "kemp eliminase", - "ke07", "de novo protein", + "ke07", "directed evolution", - "lyase" + "lyase", + "kemp eliminase" ], "keywords":[ "description", @@ -133255,11 +133549,11 @@ }, { "sim":516.0, - "partner":"5d2v" + "partner":"5d2t" }, { "sim":516.0, - "partner":"5d2t" + "partner":"5d2v" }, { "sim":516.0, @@ -133369,11 +133663,11 @@ }, { "sim":142.0, - "partner":"1jvn" + "partner":"1ox5" }, { "sim":142.0, - "partner":"1ox5" + "partner":"1jvn" }, { "sim":142.0, @@ -133545,11 +133839,11 @@ "subtitle":"Directed evolutionary changes in kemp eliminase ke07 - crystal 7 round 5", "tags":[ "de novo protein, lyase", - "kemp eliminase", - "ke07", "de novo protein", + "ke07", "directed evolution", - "lyase" + "lyase", + "kemp eliminase" ], "keywords":[ "description", @@ -133606,11 +133900,11 @@ }, { "sim":516.0, - "partner":"5d2v" + "partner":"5d2t" }, { "sim":516.0, - "partner":"5d2t" + "partner":"5d2v" }, { "sim":516.0, @@ -133720,11 +134014,11 @@ }, { "sim":142.0, - "partner":"1jvn" + "partner":"1ox5" }, { "sim":142.0, - "partner":"1ox5" + "partner":"1jvn" }, { "sim":142.0, @@ -133896,11 +134190,11 @@ "subtitle":"Directed evolutionary changes in kemp eliminase ke07 - crystal 9 round 5", "tags":[ "de novo protein, lyase", - "kemp eliminase", - "ke07", "de novo protein", + "ke07", "directed evolution", - "lyase" + "lyase", + "kemp eliminase" ], "keywords":[ "description", @@ -133937,11 +134231,11 @@ "seq_thr_sim_designed":[ { "sim":528.0, - "partner":"5d2x" + "partner":"5d2y" }, { "sim":528.0, - "partner":"5d2y" + "partner":"5d2x" }, { "sim":519.0, @@ -133957,11 +134251,11 @@ }, { "sim":516.0, - "partner":"5d2v" + "partner":"5d2t" }, { "sim":516.0, - "partner":"5d2t" + "partner":"5d2v" }, { "sim":516.0, @@ -134071,11 +134365,11 @@ }, { "sim":142.0, - "partner":"1jvn" + "partner":"1ox5" }, { "sim":142.0, - "partner":"1ox5" + "partner":"1jvn" }, { "sim":142.0, @@ -134192,7 +134486,7 @@ ], "seq_max_sim_designed":{ "sim":528.0, - "partner":"5d2x" + "partner":"5d2y" }, "seq_max_sim_natural":{ "sim":518.0, @@ -134247,11 +134541,11 @@ "subtitle":"Directed evolutionary changes in kemp eliminase ke07 - crystal 11 round 6", "tags":[ "de novo protein, lyase", - "kemp eliminase", - "ke07", "de novo protein", + "ke07", "directed evolution", - "lyase" + "lyase", + "kemp eliminase" ], "keywords":[ "description", @@ -134292,11 +134586,11 @@ }, { "sim":519.0, - "partner":"5d2x" + "partner":"5d2y" }, { "sim":519.0, - "partner":"5d2y" + "partner":"5d2x" }, { "sim":515.0, @@ -134316,11 +134610,11 @@ }, { "sim":510.0, - "partner":"5d2v" + "partner":"5d2t" }, { "sim":510.0, - "partner":"5d2t" + "partner":"5d2v" }, { "sim":510.0, @@ -134422,11 +134716,11 @@ }, { "sim":143.0, - "partner":"1jvn" + "partner":"1ox5" }, { "sim":143.0, - "partner":"1ox5" + "partner":"1jvn" }, { "sim":143.0, @@ -134582,11 +134876,11 @@ "subtitle":"Directed evolutionary changes in kemp eliminase ke07 - crystal 12 round 7", "tags":[ "de novo protein, lyase", - "kemp eliminase", - "ke07", "de novo protein", + "ke07", "directed evolution", - "lyase" + "lyase", + "kemp eliminase" ], "keywords":[ "description", @@ -134639,11 +134933,11 @@ }, { "sim":511.0, - "partner":"5d2x" + "partner":"5d2y" }, { "sim":511.0, - "partner":"5d2y" + "partner":"5d2x" }, { "sim":500.0, @@ -134651,11 +134945,11 @@ }, { "sim":500.0, - "partner":"5d2v" + "partner":"5d2t" }, { "sim":500.0, - "partner":"5d2t" + "partner":"5d2v" }, { "sim":500.0, @@ -134757,11 +135051,11 @@ }, { "sim":145.0, - "partner":"1jvn" + "partner":"1ox5" }, { "sim":145.0, - "partner":"1ox5" + "partner":"1jvn" }, { "sim":145.0, @@ -134817,30 +135111,30 @@ "sim":0.9908999801, "partner":"5d38" }, - { - "sim":0.9893000126, - "partner":"5d37" - }, { "sim":0.9880999923, "partner":"5d32" }, { - "sim":0.9832000136, - "partner":"5d30" + "sim":0.9876999855, + "partner":"5d2x" }, { - "sim":0.9749000072, - "partner":"5d2y" + "sim":0.9893000126, + "partner":"5d37" }, { - "sim":0.9876999855, - "partner":"5d2x" + "sim":0.9832000136, + "partner":"5d30" }, { "sim":0.9746000171, "partner":"5d2v" }, + { + "sim":0.9749000072, + "partner":"5d2y" + }, { "sim":0.9746999741, "partner":"5d2w" @@ -134855,18 +135149,10 @@ } ], "struct_thr_sim_natural":[ - { - "sim":0.9926000237, - "partner":"3iiv" - }, { "sim":0.9688000083, "partner":"3iio" }, - { - "sim":0.9631000161, - "partner":"3iip" - }, { "sim":0.9728000164, "partner":"2rkx" @@ -134874,6 +135160,14 @@ { "sim":0.9725000262, "partner":"2a0n" + }, + { + "sim":0.9926000237, + "partner":"3iiv" + }, + { + "sim":0.9631000161, + "partner":"3iip" } ], "seq_max_sim_designed":{ @@ -134933,11 +135227,11 @@ "subtitle":"Directed evolutionary changes in kemp eliminase ke07 - crystal 16 round 7", "tags":[ "de novo protein, lyase", - "kemp eliminase", - "ke07", "de novo protein", + "ke07", "directed evolution", - "lyase" + "lyase", + "kemp eliminase" ], "keywords":[ "description", @@ -134990,11 +135284,11 @@ }, { "sim":511.0, - "partner":"5d2x" + "partner":"5d2y" }, { "sim":511.0, - "partner":"5d2y" + "partner":"5d2x" }, { "sim":500.0, @@ -135002,11 +135296,11 @@ }, { "sim":500.0, - "partner":"5d2v" + "partner":"5d2t" }, { "sim":500.0, - "partner":"5d2t" + "partner":"5d2v" }, { "sim":500.0, @@ -135108,11 +135402,11 @@ }, { "sim":145.0, - "partner":"1jvn" + "partner":"1ox5" }, { "sim":145.0, - "partner":"1ox5" + "partner":"1jvn" }, { "sim":145.0, @@ -135280,11 +135574,11 @@ "subtitle":"Directed evolutionary changes in kemp eliminase ke07 - crystal 17 round 7-2", "tags":[ "de novo protein, lyase", - "kemp eliminase", - "ke07", "de novo protein", + "ke07", "directed evolution", - "lyase" + "lyase", + "kemp eliminase" ], "keywords":[ "description", @@ -135325,11 +135619,11 @@ }, { "sim":519.0, - "partner":"5d2x" + "partner":"5d2y" }, { "sim":519.0, - "partner":"5d2y" + "partner":"5d2x" }, { "sim":516.0, @@ -135349,11 +135643,11 @@ }, { "sim":507.0, - "partner":"5d2v" + "partner":"5d2t" }, { "sim":507.0, - "partner":"5d2t" + "partner":"5d2v" }, { "sim":507.0, @@ -135455,11 +135749,11 @@ }, { "sim":143.0, - "partner":"1jvn" + "partner":"1ox5" }, { "sim":143.0, - "partner":"1ox5" + "partner":"1jvn" }, { "sim":143.0, @@ -135534,13 +135828,17 @@ ], "struct_thr_sim_natural":[ { - "sim":0.9557999969, - "partner":"3iip" + "sim":0.9635000229, + "partner":"3iiv" }, { "sim":0.9581999779, "partner":"3iio" }, + { + "sim":0.9557999969, + "partner":"3iip" + }, { "sim":0.9624999762, "partner":"2rkx" @@ -135548,10 +135846,6 @@ { "sim":0.9602000117, "partner":"2a0n" - }, - { - "sim":0.9635000229, - "partner":"3iiv" } ], "seq_max_sim_designed":{ @@ -135630,96 +135924,96 @@ ], "subtitle":"Beta1 t801 loop variant in p3221", "tags":[ - "synthetic protein", "de novo protein", - "protein design" + "protein design", + "synthetic protein" ], "keywords":[ - "domain", - "matches", - "use", - "designed", - "goals", - "basic", - "repetitive", - "experimentally", - "crystal", - "target", - "based", - "synthetic", - "conformation", - "structure", - "repeat", - "computationally", - "however", - "nanotechnology", - "without", - "pentapeptide", - "incorrect", - "proteins", - "solved", - "de", - "family", - "variants", - "ability", - "chemically", - "better", - "simplifying", - "onto", - "structures", - "construct", - "atomic", - "intrinsically", - "loops", - "large", - "globular", "resolution", - "class", - "fragments", - "closely", - "shown", - "unit", - "design", - "core", - "unsolved", "key", + "repeat", "clearly", - "known", + "generalized", + "intrinsically", + "core", + "precision", "appeared", - "designs", - "one", - "approach", - "showing", - "also", + "unsolved", + "folding", + "goals", + "protein", + "globular", + "simplifying", "novo", - "insertions", - "length", + "domains", "inserting", + "two", "offer", + "crystal", "attractive", - "biologically", - "modular", - "generalized", + "conformation", + "however", + "computationally", + "experimentally", + "family", + "level", + "matches", + "nanotechnology", + "approach", + "showing", + "proteins", + "large", "constructed", - "precision", - "understood", - "extension", - "two", - "problem", + "use", + "modular", "scaffold", - "domains", - "synthesized", - "protein", - "backbone", - "projecting", - "hairpin", + "pentapeptide", + "construct", "computational", + "design", + "onto", + "atomic", + "length", "accommodate", - "folding", + "loops", + "incorrect", + "resolved", + "domain", + "also", + "projecting", + "chemically", + "shown", + "understood", + "backbone", + "ability", + "solved", + "insertions", "developed", + "designed", + "basic", + "one", "loop", - "level", - "resolved" + "variants", + "extension", + "structures", + "de", + "fragments", + "synthesized", + "based", + "hairpin", + "without", + "structure", + "synthetic", + "repetitive", + "closely", + "target", + "biologically", + "known", + "class", + "unit", + "problem", + "designs", + "better" ], "release_date":"2016-08-31", "publication":"\"Synthetic beta-solenoid proteins with the fragment-free computational design of a beta-hairpin extension\", Proc.Natl.Acad.Sci.USA, 113, 10346-10351", @@ -135768,11 +136062,11 @@ }, { "sim":408.0, - "partner":"5dzb" + "partner":"4yfo" }, { "sim":408.0, - "partner":"4yfo" + "partner":"5dzb" }, { "sim":374.0, @@ -135854,27 +136148,27 @@ }, { "sim":57.0, - "partner":"4evc" + "partner":"3ta8" }, { "sim":57.0, - "partner":"4evd" + "partner":"3t9j" }, { "sim":57.0, - "partner":"4eve" + "partner":"4evb" }, { "sim":57.0, - "partner":"3ta8" + "partner":"4evc" }, { "sim":57.0, - "partner":"3t9j" + "partner":"4evd" }, { "sim":57.0, - "partner":"4evb" + "partner":"4eve" }, { "sim":57.0, @@ -135944,10 +136238,6 @@ "sim":55.0, "partner":"3nd1" }, - { - "sim":55.0, - "partner":"4d2w" - }, { "sim":55.0, "partner":"4d2p" @@ -135982,11 +136272,11 @@ }, { "sim":55.0, - "partner":"2rim" + "partner":"4d2w" }, { - "sim":54.0, - "partner":"3rg6" + "sim":55.0, + "partner":"2rim" }, { "sim":54.0, @@ -136000,6 +136290,10 @@ "sim":54.0, "partner":"2peo" }, + { + "sim":54.0, + "partner":"3rg6" + }, { "sim":54.0, "partner":"2mux" @@ -136140,10 +136434,6 @@ "sim":53.0, "partner":"2ews" }, - { - "sim":53.0, - "partner":"4rtl" - }, { "sim":53.0, "partner":"4rtm" @@ -136186,7 +136476,7 @@ }, { "sim":53.0, - "partner":"3ws7" + "partner":"4rtl" }, { "sim":53.0, @@ -136198,11 +136488,7 @@ }, { "sim":53.0, - "partner":"4h2w" - }, - { - "sim":53.0, - "partner":"3mey" + "partner":"3ws7" }, { "sim":53.0, @@ -136240,6 +136526,14 @@ "sim":53.0, "partner":"4h2v" }, + { + "sim":53.0, + "partner":"4h2w" + }, + { + "sim":53.0, + "partner":"3mey" + }, { "sim":53.0, "partner":"4ku2" @@ -136328,10 +136622,6 @@ "sim":52.0, "partner":"4cng" }, - { - "sim":52.0, - "partner":"4yvk" - }, { "sim":52.0, "partner":"4yqd" @@ -136356,6 +136646,10 @@ "sim":52.0, "partner":"4yvj" }, + { + "sim":52.0, + "partner":"4yvk" + }, { "sim":52.0, "partner":"1uaj" @@ -136496,10 +136790,6 @@ "sim":52.0, "partner":"4buc" }, - { - "sim":52.0, - "partner":"2q5l" - }, { "sim":52.0, "partner":"2q5o" @@ -136516,6 +136806,10 @@ "sim":52.0, "partner":"2q5j" }, + { + "sim":52.0, + "partner":"2q5l" + }, { "sim":52.0, "partner":"5d6r" @@ -136584,10 +136878,6 @@ "sim":51.0, "partner":"4xx2" }, - { - "sim":51.0, - "partner":"2vbq" - }, { "sim":51.0, "partner":"1s3z" @@ -136600,6 +136890,10 @@ "sim":51.0, "partner":"1s60" }, + { + "sim":51.0, + "partner":"2vbq" + }, { "sim":51.0, "partner":"2znz" @@ -136648,10 +136942,6 @@ "sim":51.0, "partner":"3ofv" }, - { - "sim":51.0, - "partner":"5bnq" - }, { "sim":51.0, "partner":"3me2" @@ -136662,12 +136952,16 @@ }, { "sim":51.0, - "partner":"3oci" + "partner":"5bnq" }, { "sim":51.0, "partner":"3oc3" }, + { + "sim":51.0, + "partner":"3oci" + }, { "sim":51.0, "partner":"1upi" @@ -136714,15 +137008,15 @@ }, { "sim":51.0, - "partner":"4be6" + "partner":"4bei" }, { "sim":51.0, - "partner":"4bei" + "partner":"4be5" }, { "sim":51.0, - "partner":"4be5" + "partner":"4be6" }, { "sim":51.0, @@ -136754,27 +137048,35 @@ }, { "sim":51.0, - "partner":"3et1" + "partner":"8rwr" }, { "sim":51.0, - "partner":"1z6k" + "partner":"8rws" }, { "sim":51.0, - "partner":"1xse" + "partner":"8rwo" }, { "sim":51.0, - "partner":"4jgt" + "partner":"8rwp" }, { "sim":51.0, - "partner":"3g3d" + "partner":"3et1" }, { "sim":51.0, - "partner":"5a7y" + "partner":"1z6k" + }, + { + "sim":51.0, + "partner":"1xse" + }, + { + "sim":51.0, + "partner":"4jgt" }, { "sim":51.0, @@ -136792,6 +137094,14 @@ "sim":51.0, "partner":"4hkp" }, + { + "sim":51.0, + "partner":"3g3d" + }, + { + "sim":51.0, + "partner":"5a7y" + }, { "sim":51.0, "partner":"4iwx" @@ -136834,39 +137144,39 @@ }, { "sim":51.0, - "partner":"3sie" + "partner":"4i9z" }, { "sim":51.0, - "partner":"4g2w" + "partner":"4ia0" }, { "sim":51.0, - "partner":"4g2y" + "partner":"4oew" }, { "sim":51.0, - "partner":"4i9z" + "partner":"4oex" }, { "sim":51.0, - "partner":"4ia0" + "partner":"3shy" }, { "sim":51.0, - "partner":"4oew" + "partner":"3shz" }, { "sim":51.0, - "partner":"4oex" + "partner":"3sie" }, { "sim":51.0, - "partner":"3shy" + "partner":"4g2w" }, { "sim":51.0, - "partner":"3shz" + "partner":"4g2y" }, { "sim":51.0, @@ -136896,10 +137206,6 @@ "sim":51.0, "partner":"3wxm" }, - { - "sim":51.0, - "partner":"3c1y" - }, { "sim":51.0, "partner":"3c1z" @@ -136924,6 +137230,10 @@ "sim":51.0, "partner":"4yxm" }, + { + "sim":51.0, + "partner":"3c1y" + }, { "sim":51.0, "partner":"2rjg" @@ -136972,10 +137282,6 @@ "sim":51.0, "partner":"3vvm" }, - { - "sim":51.0, - "partner":"2y6r" - }, { "sim":51.0, "partner":"4a99" @@ -136996,6 +137302,10 @@ "sim":51.0, "partner":"2y6q" }, + { + "sim":51.0, + "partner":"2y6r" + }, { "sim":51.0, "partner":"3k01" @@ -137044,10 +137354,6 @@ "sim":51.0, "partner":"4lf2" }, - { - "sim":51.0, - "partner":"4cdm" - }, { "sim":51.0, "partner":"4cdn" @@ -137060,6 +137366,10 @@ "sim":51.0, "partner":"2xrz" }, + { + "sim":51.0, + "partner":"4cdm" + }, { "sim":51.0, "partner":"3ug3" @@ -137088,10 +137398,6 @@ "sim":51.0, "partner":"3qfb" }, - { - "sim":51.0, - "partner":"2cj9" - }, { "sim":51.0, "partner":"2cja" @@ -137104,6 +137410,10 @@ "sim":51.0, "partner":"2cjb" }, + { + "sim":51.0, + "partner":"2cj9" + }, { "sim":51.0, "partner":"4s21" @@ -137182,11 +137492,11 @@ }, { "sim":50.0, - "partner":"3gz2" + "partner":"4oml" }, { "sim":50.0, - "partner":"4oml" + "partner":"3gz2" }, { "sim":50.0, @@ -137250,15 +137560,15 @@ }, { "sim":50.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":50.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":50.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":50.0, @@ -137286,15 +137596,15 @@ }, { "sim":50.0, - "partner":"3sw1" + "partner":"5j3w" }, { "sim":50.0, - "partner":"5j3w" + "partner":"5j4e" }, { "sim":50.0, - "partner":"5j4e" + "partner":"3sw1" }, { "sim":50.0, @@ -137310,11 +137620,11 @@ }, { "sim":50.0, - "partner":"2ela" + "partner":"2b6b" }, { "sim":50.0, - "partner":"2b6b" + "partner":"2ela" }, { "sim":50.0, @@ -137354,11 +137664,11 @@ }, { "sim":50.0, - "partner":"4kce" + "partner":"2h66" }, { "sim":50.0, - "partner":"2h66" + "partner":"4kce" }, { "sim":50.0, @@ -137374,11 +137684,11 @@ }, { "sim":50.0, - "partner":"4jr4" + "partner":"4jr6" }, { "sim":50.0, - "partner":"4jr6" + "partner":"4jr4" }, { "sim":50.0, @@ -137404,10 +137714,6 @@ "sim":50.0, "partner":"2fz4" }, - { - "sim":50.0, - "partner":"3la7" - }, { "sim":50.0, "partner":"3la2" @@ -137418,15 +137724,15 @@ }, { "sim":50.0, - "partner":"3r6s" + "partner":"3la7" }, { "sim":50.0, - "partner":"2rde" + "partner":"3r6s" }, { "sim":50.0, - "partner":"4da6" + "partner":"2rde" }, { "sim":50.0, @@ -137480,6 +137786,10 @@ "sim":50.0, "partner":"4d8v" }, + { + "sim":50.0, + "partner":"4da6" + }, { "sim":50.0, "partner":"2yfa" @@ -137494,15 +137804,15 @@ }, { "sim":50.0, - "partner":"1zw3" + "partner":"1zvz" }, { "sim":50.0, - "partner":"1zvz" + "partner":"1zw2" }, { "sim":50.0, - "partner":"1zw2" + "partner":"1zw3" }, { "sim":50.0, @@ -137516,10 +137826,6 @@ "sim":50.0, "partner":"2jfq" }, - { - "sim":50.0, - "partner":"4rdh" - }, { "sim":50.0, "partner":"4rdi" @@ -137544,6 +137850,10 @@ "sim":50.0, "partner":"5djj" }, + { + "sim":50.0, + "partner":"4rdh" + }, { "sim":50.0, "partner":"5djk" @@ -137570,11 +137880,11 @@ }, { "sim":50.0, - "partner":"3ta4" + "partner":"3t9w" }, { "sim":50.0, - "partner":"3t9w" + "partner":"3ta4" }, { "sim":50.0, @@ -137586,19 +137896,19 @@ }, { "sim":50.0, - "partner":"3nha" + "partner":"3nh6" }, { "sim":50.0, - "partner":"3nhb" + "partner":"3nh9" }, { "sim":50.0, - "partner":"3nh6" + "partner":"3nha" }, { "sim":50.0, - "partner":"3nh9" + "partner":"3nhb" }, { "sim":50.0, @@ -137606,31 +137916,31 @@ }, { "sim":50.0, - "partner":"3ggo" + "partner":"3ggp" }, { "sim":50.0, - "partner":"3ggp" + "partner":"3ggg" }, { "sim":50.0, - "partner":"3ggg" + "partner":"3ggo" }, { "sim":50.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":50.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":50.0, - "partner":"3tm8" + "partner":"3tmc" }, { "sim":50.0, - "partner":"3tmb" + "partner":"3tmd" }, { "sim":50.0, @@ -137642,15 +137952,15 @@ }, { "sim":50.0, - "partner":"2pzm" + "partner":"2pzk" }, { "sim":50.0, - "partner":"2pzk" + "partner":"2pzl" }, { "sim":50.0, - "partner":"2pzl" + "partner":"2pzm" }, { "sim":50.0, @@ -137764,10 +138074,6 @@ "sim":50.0, "partner":"3kzk" }, - { - "sim":50.0, - "partner":"4m1i" - }, { "sim":50.0, "partner":"4d8f" @@ -137780,6 +138086,10 @@ "sim":50.0, "partner":"4m1h" }, + { + "sim":50.0, + "partner":"4m1i" + }, { "sim":50.0, "partner":"5f8c" @@ -137816,14 +138126,6 @@ "sim":50.0, "partner":"4ocv" }, - { - "sim":50.0, - "partner":"4q3r" - }, - { - "sim":50.0, - "partner":"4q42" - }, { "sim":50.0, "partner":"4q3s" @@ -137858,19 +138160,23 @@ }, { "sim":50.0, - "partner":"3o2t" + "partner":"4q3r" }, { "sim":50.0, - "partner":"3bu7" + "partner":"4q42" }, { "sim":50.0, - "partner":"2xyo" + "partner":"3o2t" }, { "sim":50.0, - "partner":"4hcl" + "partner":"3bu7" + }, + { + "sim":50.0, + "partner":"2xyo" }, { "sim":50.0, @@ -137884,6 +138190,10 @@ "sim":50.0, "partner":"3au7" }, + { + "sim":50.0, + "partner":"4hcl" + }, { "sim":50.0, "partner":"4r9v" @@ -137912,17 +138222,13 @@ "sim":50.0, "partner":"3kki" }, - { - "sim":50.0, - "partner":"2gqn" - }, { "sim":50.0, "partner":"2fq6" }, { "sim":50.0, - "partner":"3wkr" + "partner":"2gqn" }, { "sim":50.0, @@ -137930,11 +138236,11 @@ }, { "sim":50.0, - "partner":"4bko" + "partner":"3wkr" }, { "sim":50.0, - "partner":"4euh" + "partner":"4bko" }, { "sim":50.0, @@ -137944,6 +138250,10 @@ "sim":50.0, "partner":"4euf" }, + { + "sim":50.0, + "partner":"4euh" + }, { "sim":50.0, "partner":"5ec4" @@ -137968,17 +138278,13 @@ "sim":50.0, "partner":"2alm" }, - { - "sim":50.0, - "partner":"2yhg" - }, { "sim":50.0, "partner":"4doy" }, { "sim":50.0, - "partner":"3amu" + "partner":"2yhg" }, { "sim":50.0, @@ -137986,11 +138292,11 @@ }, { "sim":50.0, - "partner":"2yjn" + "partner":"3amu" }, { "sim":50.0, - "partner":"2r98" + "partner":"2yjn" }, { "sim":50.0, @@ -138012,6 +138318,10 @@ "sim":50.0, "partner":"4i49" }, + { + "sim":50.0, + "partner":"2r98" + }, { "sim":50.0, "partner":"3qfs" @@ -138076,10 +138386,6 @@ "sim":50.0, "partner":"4tmu" }, - { - "sim":50.0, - "partner":"2r0p" - }, { "sim":50.0, "partner":"2r0c" @@ -138102,16 +138408,20 @@ }, { "sim":50.0, - "partner":"8rpf" + "partner":"2r0p" }, { "sim":50.0, - "partner":"5ess" + "partner":"8rpf" }, { "sim":50.0, "partner":"5esd" }, + { + "sim":50.0, + "partner":"5ess" + }, { "sim":50.0, "partner":"5esu" @@ -138140,17 +138450,13 @@ "sim":50.0, "partner":"3fjo" }, - { - "sim":50.0, - "partner":"4gyk" - }, { "sim":50.0, "partner":"4gyj" }, { "sim":50.0, - "partner":"2fw3" + "partner":"4gyk" }, { "sim":50.0, @@ -138172,6 +138478,10 @@ "sim":50.0, "partner":"4eph" }, + { + "sim":50.0, + "partner":"2fw3" + }, { "sim":50.0, "partner":"2bpo" @@ -138313,95 +138623,95 @@ ], "subtitle":"T1555 loop variant", "tags":[ - "synthetic protein", - "de novo protein" + "de novo protein", + "synthetic protein" ], "keywords":[ - "domain", - "matches", - "use", - "designed", - "goals", - "basic", - "repetitive", - "experimentally", - "crystal", - "target", - "based", - "synthetic", - "conformation", - "structure", - "repeat", - "computationally", - "however", - "nanotechnology", - "without", - "pentapeptide", - "incorrect", - "proteins", - "solved", - "de", - "family", - "variants", - "ability", - "chemically", - "better", - "simplifying", - "onto", - "structures", - "construct", - "atomic", - "intrinsically", - "loops", - "large", - "globular", "resolution", - "class", - "fragments", - "closely", - "shown", - "unit", - "design", - "core", - "unsolved", "key", + "repeat", "clearly", - "known", + "generalized", + "intrinsically", + "core", + "precision", "appeared", - "designs", - "one", - "approach", - "showing", - "also", + "unsolved", + "folding", + "goals", + "protein", + "globular", + "simplifying", "novo", - "insertions", - "length", + "domains", "inserting", + "two", "offer", + "crystal", "attractive", - "biologically", - "modular", - "generalized", + "conformation", + "however", + "computationally", + "experimentally", + "family", + "level", + "matches", + "nanotechnology", + "approach", + "showing", + "proteins", + "large", "constructed", - "precision", - "understood", - "extension", - "two", - "problem", + "use", + "modular", "scaffold", - "domains", - "synthesized", - "protein", - "backbone", - "projecting", - "hairpin", + "pentapeptide", + "construct", "computational", + "design", + "onto", + "atomic", + "length", "accommodate", - "folding", + "loops", + "incorrect", + "resolved", + "domain", + "also", + "projecting", + "chemically", + "shown", + "understood", + "backbone", + "ability", + "solved", + "insertions", "developed", + "designed", + "basic", + "one", "loop", - "level", - "resolved" + "variants", + "extension", + "structures", + "de", + "fragments", + "synthesized", + "based", + "hairpin", + "without", + "structure", + "synthetic", + "repetitive", + "closely", + "target", + "biologically", + "known", + "class", + "unit", + "problem", + "designs", + "better" ], "release_date":"2016-08-31", "publication":"\"Synthetic beta-solenoid proteins with the fragment-free computational design of a beta-hairpin extension\", Proc.Natl.Acad.Sci.USA, 113, 10346-10351", @@ -138450,11 +138760,11 @@ }, { "sim":415.0, - "partner":"5dzb" + "partner":"4yfo" }, { "sim":415.0, - "partner":"4yfo" + "partner":"5dzb" }, { "sim":377.0, @@ -138532,27 +138842,27 @@ }, { "sim":57.0, - "partner":"4evc" + "partner":"3ta8" }, { "sim":57.0, - "partner":"4evd" + "partner":"3t9j" }, { "sim":57.0, - "partner":"4eve" + "partner":"4evb" }, { "sim":57.0, - "partner":"3ta8" + "partner":"4evc" }, { "sim":57.0, - "partner":"3t9j" + "partner":"4evd" }, { "sim":57.0, - "partner":"4evb" + "partner":"4eve" }, { "sim":57.0, @@ -138566,10 +138876,6 @@ "sim":57.0, "partner":"2b4u" }, - { - "sim":57.0, - "partner":"4d2w" - }, { "sim":57.0, "partner":"4d2p" @@ -138602,6 +138908,10 @@ "sim":57.0, "partner":"4d2v" }, + { + "sim":57.0, + "partner":"4d2w" + }, { "sim":56.0, "partner":"4k8g" @@ -138646,10 +138956,6 @@ "sim":55.0, "partner":"2rim" }, - { - "sim":54.0, - "partner":"3rg6" - }, { "sim":54.0, "partner":"2wvw" @@ -138662,6 +138968,10 @@ "sim":54.0, "partner":"2peo" }, + { + "sim":54.0, + "partner":"3rg6" + }, { "sim":54.0, "partner":"3ffl" @@ -138778,10 +139088,6 @@ "sim":53.0, "partner":"2ews" }, - { - "sim":53.0, - "partner":"4rtl" - }, { "sim":53.0, "partner":"4rtm" @@ -138824,7 +139130,7 @@ }, { "sim":53.0, - "partner":"3ws7" + "partner":"4rtl" }, { "sim":53.0, @@ -138836,11 +139142,7 @@ }, { "sim":53.0, - "partner":"4h2w" - }, - { - "sim":53.0, - "partner":"3mey" + "partner":"3ws7" }, { "sim":53.0, @@ -138878,6 +139180,14 @@ "sim":53.0, "partner":"4h2v" }, + { + "sim":53.0, + "partner":"4h2w" + }, + { + "sim":53.0, + "partner":"3mey" + }, { "sim":53.0, "partner":"4l3f" @@ -138950,10 +139260,6 @@ "sim":52.0, "partner":"4p6c" }, - { - "sim":52.0, - "partner":"4yvk" - }, { "sim":52.0, "partner":"4yqd" @@ -138978,6 +139284,10 @@ "sim":52.0, "partner":"4yvj" }, + { + "sim":52.0, + "partner":"4yvk" + }, { "sim":52.0, "partner":"1uaj" @@ -139118,10 +139428,6 @@ "sim":52.0, "partner":"3s7y" }, - { - "sim":52.0, - "partner":"2q5l" - }, { "sim":52.0, "partner":"2q5o" @@ -139138,6 +139444,10 @@ "sim":52.0, "partner":"2q5j" }, + { + "sim":52.0, + "partner":"2q5l" + }, { "sim":52.0, "partner":"5d6r" @@ -139234,10 +139544,6 @@ "sim":51.0, "partner":"4lfn" }, - { - "sim":51.0, - "partner":"2vbq" - }, { "sim":51.0, "partner":"1s3z" @@ -139250,6 +139556,10 @@ "sim":51.0, "partner":"1s60" }, + { + "sim":51.0, + "partner":"2vbq" + }, { "sim":51.0, "partner":"2znz" @@ -139302,10 +139612,6 @@ "sim":51.0, "partner":"3ofv" }, - { - "sim":51.0, - "partner":"5bnq" - }, { "sim":51.0, "partner":"3me2" @@ -139316,12 +139622,16 @@ }, { "sim":51.0, - "partner":"3oci" + "partner":"5bnq" }, { "sim":51.0, "partner":"3oc3" }, + { + "sim":51.0, + "partner":"3oci" + }, { "sim":51.0, "partner":"1upi" @@ -139360,11 +139670,11 @@ }, { "sim":51.0, - "partner":"3rpu" + "partner":"8tlb" }, { "sim":51.0, - "partner":"8tlb" + "partner":"3rpu" }, { "sim":51.0, @@ -139372,15 +139682,15 @@ }, { "sim":51.0, - "partner":"4be6" + "partner":"4bei" }, { "sim":51.0, - "partner":"4bei" + "partner":"4be5" }, { "sim":51.0, - "partner":"4be5" + "partner":"4be6" }, { "sim":51.0, @@ -139412,31 +139722,31 @@ }, { "sim":51.0, - "partner":"3quo" + "partner":"3qur" }, { "sim":51.0, - "partner":"3qvf" + "partner":"3qvh" }, { "sim":51.0, - "partner":"3qur" + "partner":"3d40" }, { "sim":51.0, - "partner":"3qvh" + "partner":"3d41" }, { "sim":51.0, - "partner":"3d40" + "partner":"3qun" }, { "sim":51.0, - "partner":"3d41" + "partner":"3quo" }, { "sim":51.0, - "partner":"3qun" + "partner":"3qvf" }, { "sim":51.0, @@ -139444,35 +139754,43 @@ }, { "sim":51.0, - "partner":"3et1" + "partner":"8rwr" }, { "sim":51.0, - "partner":"1z6k" + "partner":"8rws" }, { "sim":51.0, - "partner":"2rhq" + "partner":"8rwo" }, { "sim":51.0, - "partner":"2rhs" + "partner":"8rwp" }, { "sim":51.0, - "partner":"1xse" + "partner":"3et1" }, { "sim":51.0, - "partner":"4jgt" + "partner":"1z6k" }, { "sim":51.0, - "partner":"3nha" + "partner":"2rhq" }, { "sim":51.0, - "partner":"3nhb" + "partner":"2rhs" + }, + { + "sim":51.0, + "partner":"1xse" + }, + { + "sim":51.0, + "partner":"4jgt" }, { "sim":51.0, @@ -139484,11 +139802,11 @@ }, { "sim":51.0, - "partner":"3g3d" + "partner":"3nha" }, { "sim":51.0, - "partner":"5a7y" + "partner":"3nhb" }, { "sim":51.0, @@ -139506,6 +139824,14 @@ "sim":51.0, "partner":"4hkp" }, + { + "sim":51.0, + "partner":"3g3d" + }, + { + "sim":51.0, + "partner":"5a7y" + }, { "sim":51.0, "partner":"4iwx" @@ -139548,39 +139874,39 @@ }, { "sim":51.0, - "partner":"3sie" + "partner":"4i9z" }, { "sim":51.0, - "partner":"4g2w" + "partner":"4ia0" }, { "sim":51.0, - "partner":"4g2y" + "partner":"4oew" }, { "sim":51.0, - "partner":"4i9z" + "partner":"4oex" }, { "sim":51.0, - "partner":"4ia0" + "partner":"3shy" }, { "sim":51.0, - "partner":"4oew" + "partner":"3shz" }, { "sim":51.0, - "partner":"4oex" + "partner":"3sie" }, { "sim":51.0, - "partner":"3shy" + "partner":"4g2w" }, { "sim":51.0, - "partner":"3shz" + "partner":"4g2y" }, { "sim":51.0, @@ -139610,10 +139936,6 @@ "sim":51.0, "partner":"3wxm" }, - { - "sim":51.0, - "partner":"3c1y" - }, { "sim":51.0, "partner":"3c1z" @@ -139638,6 +139960,10 @@ "sim":51.0, "partner":"4yxm" }, + { + "sim":51.0, + "partner":"3c1y" + }, { "sim":51.0, "partner":"2rjg" @@ -139690,10 +140016,6 @@ "sim":51.0, "partner":"5awm" }, - { - "sim":51.0, - "partner":"2y6r" - }, { "sim":51.0, "partner":"4a99" @@ -139714,6 +140036,10 @@ "sim":51.0, "partner":"2y6q" }, + { + "sim":51.0, + "partner":"2y6r" + }, { "sim":51.0, "partner":"3k01" @@ -139762,10 +140088,6 @@ "sim":51.0, "partner":"4lf2" }, - { - "sim":51.0, - "partner":"4cdm" - }, { "sim":51.0, "partner":"4cdn" @@ -139778,6 +140100,10 @@ "sim":51.0, "partner":"2xrz" }, + { + "sim":51.0, + "partner":"4cdm" + }, { "sim":51.0, "partner":"3ug3" @@ -139806,10 +140132,6 @@ "sim":51.0, "partner":"3qfb" }, - { - "sim":51.0, - "partner":"2cj9" - }, { "sim":51.0, "partner":"2cja" @@ -139822,6 +140144,10 @@ "sim":51.0, "partner":"2cjb" }, + { + "sim":51.0, + "partner":"2cj9" + }, { "sim":51.0, "partner":"4s21" @@ -139872,11 +140198,11 @@ }, { "sim":50.0, - "partner":"3gz2" + "partner":"4oml" }, { "sim":50.0, - "partner":"4oml" + "partner":"3gz2" }, { "sim":50.0, @@ -139940,15 +140266,15 @@ }, { "sim":50.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":50.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":50.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":50.0, @@ -139976,15 +140302,15 @@ }, { "sim":50.0, - "partner":"3sw1" + "partner":"5j3w" }, { "sim":50.0, - "partner":"5j3w" + "partner":"5j4e" }, { "sim":50.0, - "partner":"5j4e" + "partner":"3sw1" }, { "sim":50.0, @@ -140004,11 +140330,11 @@ }, { "sim":50.0, - "partner":"2ela" + "partner":"2b6b" }, { "sim":50.0, - "partner":"2b6b" + "partner":"2ela" }, { "sim":50.0, @@ -140056,11 +140382,11 @@ }, { "sim":50.0, - "partner":"4kce" + "partner":"2h66" }, { "sim":50.0, - "partner":"2h66" + "partner":"4kce" }, { "sim":50.0, @@ -140076,11 +140402,11 @@ }, { "sim":50.0, - "partner":"4jr4" + "partner":"4jr6" }, { "sim":50.0, - "partner":"4jr6" + "partner":"4jr4" }, { "sim":50.0, @@ -140106,10 +140432,6 @@ "sim":50.0, "partner":"2fz4" }, - { - "sim":50.0, - "partner":"3la7" - }, { "sim":50.0, "partner":"3la2" @@ -140120,15 +140442,15 @@ }, { "sim":50.0, - "partner":"3r6s" + "partner":"3la7" }, { "sim":50.0, - "partner":"2rde" + "partner":"3r6s" }, { "sim":50.0, - "partner":"4da6" + "partner":"2rde" }, { "sim":50.0, @@ -140182,6 +140504,10 @@ "sim":50.0, "partner":"4d8v" }, + { + "sim":50.0, + "partner":"4da6" + }, { "sim":50.0, "partner":"2yfa" @@ -140200,15 +140526,15 @@ }, { "sim":50.0, - "partner":"1zw3" + "partner":"1zvz" }, { "sim":50.0, - "partner":"1zvz" + "partner":"1zw2" }, { "sim":50.0, - "partner":"1zw2" + "partner":"1zw3" }, { "sim":50.0, @@ -140222,10 +140548,6 @@ "sim":50.0, "partner":"2jfq" }, - { - "sim":50.0, - "partner":"4rdh" - }, { "sim":50.0, "partner":"4rdi" @@ -140250,6 +140572,10 @@ "sim":50.0, "partner":"5djj" }, + { + "sim":50.0, + "partner":"4rdh" + }, { "sim":50.0, "partner":"5djk" @@ -140268,11 +140594,11 @@ }, { "sim":50.0, - "partner":"3ta4" + "partner":"3t9w" }, { "sim":50.0, - "partner":"3t9w" + "partner":"3ta4" }, { "sim":50.0, @@ -140288,31 +140614,31 @@ }, { "sim":50.0, - "partner":"3ggo" + "partner":"3ggp" }, { "sim":50.0, - "partner":"3ggp" + "partner":"3ggg" }, { "sim":50.0, - "partner":"3ggg" + "partner":"3ggo" }, { "sim":50.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":50.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":50.0, - "partner":"3tm8" + "partner":"3tmc" }, { "sim":50.0, - "partner":"3tmb" + "partner":"3tmd" }, { "sim":50.0, @@ -140324,15 +140650,15 @@ }, { "sim":50.0, - "partner":"2pzm" + "partner":"2pzk" }, { "sim":50.0, - "partner":"2pzk" + "partner":"2pzl" }, { "sim":50.0, - "partner":"2pzl" + "partner":"2pzm" }, { "sim":50.0, @@ -140454,10 +140780,6 @@ "sim":50.0, "partner":"3kzk" }, - { - "sim":50.0, - "partner":"4m1i" - }, { "sim":50.0, "partner":"4d8f" @@ -140470,6 +140792,10 @@ "sim":50.0, "partner":"4m1h" }, + { + "sim":50.0, + "partner":"4m1i" + }, { "sim":50.0, "partner":"2b61" @@ -140510,14 +140836,6 @@ "sim":50.0, "partner":"4ocv" }, - { - "sim":50.0, - "partner":"4q3r" - }, - { - "sim":50.0, - "partner":"4q42" - }, { "sim":50.0, "partner":"4q3s" @@ -140552,19 +140870,23 @@ }, { "sim":50.0, - "partner":"3o2t" + "partner":"4q3r" }, { "sim":50.0, - "partner":"3bu7" + "partner":"4q42" }, { "sim":50.0, - "partner":"2xyo" + "partner":"3o2t" }, { "sim":50.0, - "partner":"4hcl" + "partner":"3bu7" + }, + { + "sim":50.0, + "partner":"2xyo" }, { "sim":50.0, @@ -140578,6 +140900,10 @@ "sim":50.0, "partner":"3au7" }, + { + "sim":50.0, + "partner":"4hcl" + }, { "sim":50.0, "partner":"4r9v" @@ -140608,11 +140934,11 @@ }, { "sim":50.0, - "partner":"3wkr" + "partner":"3wks" }, { "sim":50.0, - "partner":"3wks" + "partner":"3wkr" }, { "sim":50.0, @@ -140620,15 +140946,15 @@ }, { "sim":50.0, - "partner":"4euh" + "partner":"4eue" }, { "sim":50.0, - "partner":"4eue" + "partner":"4euf" }, { "sim":50.0, - "partner":"4euf" + "partner":"4euh" }, { "sim":50.0, @@ -140656,19 +140982,19 @@ }, { "sim":50.0, - "partner":"2yhg" + "partner":"4doy" }, { "sim":50.0, - "partner":"4doy" + "partner":"2yhg" }, { "sim":50.0, - "partner":"3amu" + "partner":"3amt" }, { "sim":50.0, - "partner":"3amt" + "partner":"3amu" }, { "sim":50.0, @@ -140682,10 +141008,6 @@ "sim":50.0, "partner":"4aoa" }, - { - "sim":50.0, - "partner":"2r98" - }, { "sim":50.0, "partner":"2r8v" @@ -140706,6 +141028,10 @@ "sim":50.0, "partner":"4i49" }, + { + "sim":50.0, + "partner":"2r98" + }, { "sim":50.0, "partner":"3qfs" @@ -140770,10 +141096,6 @@ "sim":50.0, "partner":"4tmu" }, - { - "sim":50.0, - "partner":"2r0p" - }, { "sim":50.0, "partner":"2r0c" @@ -140796,12 +141118,16 @@ }, { "sim":50.0, - "partner":"5ess" + "partner":"2r0p" }, { "sim":50.0, "partner":"5esd" }, + { + "sim":50.0, + "partner":"5ess" + }, { "sim":50.0, "partner":"5esu" @@ -140830,17 +141156,13 @@ "sim":50.0, "partner":"3fjo" }, - { - "sim":50.0, - "partner":"4gyk" - }, { "sim":50.0, "partner":"4gyj" }, { "sim":50.0, - "partner":"2fw3" + "partner":"4gyk" }, { "sim":50.0, @@ -140862,6 +141184,10 @@ "sim":50.0, "partner":"4eph" }, + { + "sim":50.0, + "partner":"2fw3" + }, { "sim":50.0, "partner":"2bpo" @@ -141013,96 +141339,96 @@ ], "subtitle":"T1428 loop variant in p3221", "tags":[ - "synthetic protein", "de novo protein", - "protein design" + "protein design", + "synthetic protein" ], "keywords":[ - "domain", - "matches", - "use", - "designed", - "goals", - "basic", - "repetitive", - "experimentally", - "crystal", - "target", - "based", - "synthetic", - "conformation", - "structure", - "repeat", - "computationally", - "however", - "nanotechnology", - "without", - "pentapeptide", - "incorrect", - "proteins", - "solved", - "de", - "family", - "variants", - "ability", - "chemically", - "better", - "simplifying", - "onto", - "structures", - "construct", - "atomic", - "intrinsically", - "loops", - "large", - "globular", "resolution", - "class", - "fragments", - "closely", - "shown", - "unit", - "design", - "core", - "unsolved", "key", + "repeat", "clearly", - "known", + "generalized", + "intrinsically", + "core", + "precision", "appeared", - "designs", - "one", - "approach", - "showing", - "also", + "unsolved", + "folding", + "goals", + "protein", + "globular", + "simplifying", "novo", - "insertions", - "length", + "domains", "inserting", + "two", "offer", + "crystal", "attractive", - "biologically", - "modular", - "generalized", + "conformation", + "however", + "computationally", + "experimentally", + "family", + "level", + "matches", + "nanotechnology", + "approach", + "showing", + "proteins", + "large", "constructed", - "precision", - "understood", - "extension", - "two", - "problem", + "use", + "modular", "scaffold", - "domains", - "synthesized", - "protein", - "backbone", - "projecting", - "hairpin", + "pentapeptide", + "construct", "computational", + "design", + "onto", + "atomic", + "length", "accommodate", - "folding", + "loops", + "incorrect", + "resolved", + "domain", + "also", + "projecting", + "chemically", + "shown", + "understood", + "backbone", + "ability", + "solved", + "insertions", "developed", + "designed", + "basic", + "one", "loop", - "level", - "resolved" + "variants", + "extension", + "structures", + "de", + "fragments", + "synthesized", + "based", + "hairpin", + "without", + "structure", + "synthetic", + "repetitive", + "closely", + "target", + "biologically", + "known", + "class", + "unit", + "problem", + "designs", + "better" ], "release_date":"2016-09-28", "publication":"\"Synthetic beta-solenoid proteins with the fragment-free computational design of a beta-hairpin extension\", Proc.Natl.Acad.Sci.USA, 113, 10346-10351", @@ -141151,11 +141477,11 @@ }, { "sim":411.0, - "partner":"5dzb" + "partner":"4yfo" }, { "sim":411.0, - "partner":"4yfo" + "partner":"5dzb" }, { "sim":374.0, @@ -141237,27 +141563,27 @@ }, { "sim":57.0, - "partner":"4evc" + "partner":"3ta8" }, { "sim":57.0, - "partner":"4evd" + "partner":"3t9j" }, { "sim":57.0, - "partner":"4eve" + "partner":"4evb" }, { "sim":57.0, - "partner":"3ta8" + "partner":"4evc" }, { "sim":57.0, - "partner":"3t9j" + "partner":"4evd" }, { "sim":57.0, - "partner":"4evb" + "partner":"4eve" }, { "sim":57.0, @@ -141311,10 +141637,6 @@ "sim":55.0, "partner":"3nd1" }, - { - "sim":55.0, - "partner":"4d2w" - }, { "sim":55.0, "partner":"4d2p" @@ -141349,11 +141671,11 @@ }, { "sim":55.0, - "partner":"2rim" + "partner":"4d2w" }, { - "sim":54.0, - "partner":"3rg6" + "sim":55.0, + "partner":"2rim" }, { "sim":54.0, @@ -141367,6 +141689,10 @@ "sim":54.0, "partner":"2peo" }, + { + "sim":54.0, + "partner":"3rg6" + }, { "sim":54.0, "partner":"3ffl" @@ -141491,10 +141817,6 @@ "sim":53.0, "partner":"2ews" }, - { - "sim":53.0, - "partner":"4rtl" - }, { "sim":53.0, "partner":"4rtm" @@ -141537,7 +141859,7 @@ }, { "sim":53.0, - "partner":"3ws7" + "partner":"4rtl" }, { "sim":53.0, @@ -141549,11 +141871,7 @@ }, { "sim":53.0, - "partner":"4h2w" - }, - { - "sim":53.0, - "partner":"3mey" + "partner":"3ws7" }, { "sim":53.0, @@ -141591,6 +141909,14 @@ "sim":53.0, "partner":"4h2v" }, + { + "sim":53.0, + "partner":"4h2w" + }, + { + "sim":53.0, + "partner":"3mey" + }, { "sim":53.0, "partner":"1v33" @@ -141655,10 +141981,6 @@ "sim":52.0, "partner":"4p6c" }, - { - "sim":52.0, - "partner":"4yvk" - }, { "sim":52.0, "partner":"4yqd" @@ -141683,6 +142005,10 @@ "sim":52.0, "partner":"4yvj" }, + { + "sim":52.0, + "partner":"4yvk" + }, { "sim":52.0, "partner":"1uaj" @@ -141831,10 +142157,6 @@ "sim":52.0, "partner":"3s7y" }, - { - "sim":52.0, - "partner":"2q5l" - }, { "sim":52.0, "partner":"2q5o" @@ -141851,6 +142173,10 @@ "sim":52.0, "partner":"2q5j" }, + { + "sim":52.0, + "partner":"2q5l" + }, { "sim":52.0, "partner":"5d6r" @@ -141931,10 +142257,6 @@ "sim":51.0, "partner":"4lfn" }, - { - "sim":51.0, - "partner":"2vbq" - }, { "sim":51.0, "partner":"1s3z" @@ -141947,6 +142269,10 @@ "sim":51.0, "partner":"1s60" }, + { + "sim":51.0, + "partner":"2vbq" + }, { "sim":51.0, "partner":"2znz" @@ -141995,10 +142321,6 @@ "sim":51.0, "partner":"3ofv" }, - { - "sim":51.0, - "partner":"5bnq" - }, { "sim":51.0, "partner":"3me2" @@ -142009,12 +142331,16 @@ }, { "sim":51.0, - "partner":"3oci" + "partner":"5bnq" }, { "sim":51.0, "partner":"3oc3" }, + { + "sim":51.0, + "partner":"3oci" + }, { "sim":51.0, "partner":"1upi" @@ -142053,11 +142379,11 @@ }, { "sim":51.0, - "partner":"3rpu" + "partner":"8tlb" }, { "sim":51.0, - "partner":"8tlb" + "partner":"3rpu" }, { "sim":51.0, @@ -142065,15 +142391,15 @@ }, { "sim":51.0, - "partner":"4be6" + "partner":"4bei" }, { "sim":51.0, - "partner":"4bei" + "partner":"4be5" }, { "sim":51.0, - "partner":"4be5" + "partner":"4be6" }, { "sim":51.0, @@ -142103,6 +142429,22 @@ "sim":51.0, "partner":"8rwq" }, + { + "sim":51.0, + "partner":"8rwr" + }, + { + "sim":51.0, + "partner":"8rws" + }, + { + "sim":51.0, + "partner":"8rwo" + }, + { + "sim":51.0, + "partner":"8rwp" + }, { "sim":51.0, "partner":"3et1" @@ -142129,27 +142471,27 @@ }, { "sim":51.0, - "partner":"3g3d" + "partner":"3bvj" }, { "sim":51.0, - "partner":"5a7y" + "partner":"3mw7" }, { "sim":51.0, - "partner":"3bvj" + "partner":"4hib" }, { "sim":51.0, - "partner":"3mw7" + "partner":"4hkp" }, { "sim":51.0, - "partner":"4hib" + "partner":"3g3d" }, { "sim":51.0, - "partner":"4hkp" + "partner":"5a7y" }, { "sim":51.0, @@ -142193,43 +142535,43 @@ }, { "sim":51.0, - "partner":"3sie" + "partner":"4i9z" }, { "sim":51.0, - "partner":"4g2w" + "partner":"4ia0" }, { "sim":51.0, - "partner":"4g2y" + "partner":"4l3f" }, { "sim":51.0, - "partner":"4i9z" + "partner":"4oew" }, { "sim":51.0, - "partner":"4ia0" + "partner":"4oex" }, { "sim":51.0, - "partner":"4l3f" + "partner":"3shy" }, { "sim":51.0, - "partner":"4oew" + "partner":"3shz" }, { "sim":51.0, - "partner":"4oex" + "partner":"3sie" }, { "sim":51.0, - "partner":"3shy" + "partner":"4g2w" }, { "sim":51.0, - "partner":"3shz" + "partner":"4g2y" }, { "sim":51.0, @@ -142259,10 +142601,6 @@ "sim":51.0, "partner":"3wxm" }, - { - "sim":51.0, - "partner":"3c1y" - }, { "sim":51.0, "partner":"3c1z" @@ -142287,6 +142625,10 @@ "sim":51.0, "partner":"4yxm" }, + { + "sim":51.0, + "partner":"3c1y" + }, { "sim":51.0, "partner":"2rjg" @@ -142335,10 +142677,6 @@ "sim":51.0, "partner":"3vvm" }, - { - "sim":51.0, - "partner":"2y6r" - }, { "sim":51.0, "partner":"4a99" @@ -142359,6 +142697,10 @@ "sim":51.0, "partner":"2y6q" }, + { + "sim":51.0, + "partner":"2y6r" + }, { "sim":51.0, "partner":"3k01" @@ -142415,10 +142757,6 @@ "sim":51.0, "partner":"4lf2" }, - { - "sim":51.0, - "partner":"4cdm" - }, { "sim":51.0, "partner":"4cdn" @@ -142431,6 +142769,10 @@ "sim":51.0, "partner":"2xrz" }, + { + "sim":51.0, + "partner":"4cdm" + }, { "sim":51.0, "partner":"3ug3" @@ -142459,10 +142801,6 @@ "sim":51.0, "partner":"3qfb" }, - { - "sim":51.0, - "partner":"2cj9" - }, { "sim":51.0, "partner":"2cja" @@ -142475,6 +142813,10 @@ "sim":51.0, "partner":"2cjb" }, + { + "sim":51.0, + "partner":"2cj9" + }, { "sim":51.0, "partner":"4s21" @@ -142557,11 +142899,11 @@ }, { "sim":50.0, - "partner":"3gz2" + "partner":"4oml" }, { "sim":50.0, - "partner":"4oml" + "partner":"3gz2" }, { "sim":50.0, @@ -142625,15 +142967,15 @@ }, { "sim":50.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":50.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":50.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":50.0, @@ -142673,15 +143015,15 @@ }, { "sim":50.0, - "partner":"3sw1" + "partner":"5j3w" }, { "sim":50.0, - "partner":"5j3w" + "partner":"5j4e" }, { "sim":50.0, - "partner":"5j4e" + "partner":"3sw1" }, { "sim":50.0, @@ -142701,11 +143043,11 @@ }, { "sim":50.0, - "partner":"2ela" + "partner":"2b6b" }, { "sim":50.0, - "partner":"2b6b" + "partner":"2ela" }, { "sim":50.0, @@ -142745,11 +143087,11 @@ }, { "sim":50.0, - "partner":"4kce" + "partner":"2h66" }, { "sim":50.0, - "partner":"2h66" + "partner":"4kce" }, { "sim":50.0, @@ -142765,11 +143107,11 @@ }, { "sim":50.0, - "partner":"4jr4" + "partner":"4jr6" }, { "sim":50.0, - "partner":"4jr6" + "partner":"4jr4" }, { "sim":50.0, @@ -142795,10 +143137,6 @@ "sim":50.0, "partner":"2fz4" }, - { - "sim":50.0, - "partner":"3la7" - }, { "sim":50.0, "partner":"3la2" @@ -142809,15 +143147,15 @@ }, { "sim":50.0, - "partner":"3r6s" + "partner":"3la7" }, { "sim":50.0, - "partner":"2rde" + "partner":"3r6s" }, { "sim":50.0, - "partner":"4da6" + "partner":"2rde" }, { "sim":50.0, @@ -142873,19 +143211,19 @@ }, { "sim":50.0, - "partner":"2yfa" + "partner":"4da6" }, { "sim":50.0, - "partner":"2yfb" + "partner":"2yfa" }, { "sim":50.0, - "partner":"1sny" + "partner":"2yfb" }, { "sim":50.0, - "partner":"1zw3" + "partner":"1sny" }, { "sim":50.0, @@ -142897,19 +143235,15 @@ }, { "sim":50.0, - "partner":"3nei" - }, - { - "sim":50.0, - "partner":"3hkx" + "partner":"1zw3" }, { "sim":50.0, - "partner":"3quo" + "partner":"3nei" }, { "sim":50.0, - "partner":"3qvf" + "partner":"3hkx" }, { "sim":50.0, @@ -142937,15 +143271,19 @@ }, { "sim":50.0, - "partner":"5kya" + "partner":"3quo" }, { "sim":50.0, - "partner":"5kyj" + "partner":"3qvf" }, { "sim":50.0, - "partner":"4rdh" + "partner":"5kya" + }, + { + "sim":50.0, + "partner":"5kyj" }, { "sim":50.0, @@ -142971,6 +143309,10 @@ "sim":50.0, "partner":"5djj" }, + { + "sim":50.0, + "partner":"4rdh" + }, { "sim":50.0, "partner":"5djk" @@ -142989,11 +143331,11 @@ }, { "sim":50.0, - "partner":"3ta4" + "partner":"3t9w" }, { "sim":50.0, - "partner":"3t9w" + "partner":"3ta4" }, { "sim":50.0, @@ -143005,19 +143347,19 @@ }, { "sim":50.0, - "partner":"3nha" + "partner":"3nh6" }, { "sim":50.0, - "partner":"3nhb" + "partner":"3nh9" }, { "sim":50.0, - "partner":"3nh6" + "partner":"3nha" }, { "sim":50.0, - "partner":"3nh9" + "partner":"3nhb" }, { "sim":50.0, @@ -143033,31 +143375,31 @@ }, { "sim":50.0, - "partner":"3ggo" + "partner":"3ggp" }, { "sim":50.0, - "partner":"3ggp" + "partner":"3ggg" }, { "sim":50.0, - "partner":"3ggg" + "partner":"3ggo" }, { "sim":50.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":50.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":50.0, - "partner":"3tm8" + "partner":"3tmc" }, { "sim":50.0, - "partner":"3tmb" + "partner":"3tmd" }, { "sim":50.0, @@ -143069,15 +143411,15 @@ }, { "sim":50.0, - "partner":"2pzm" + "partner":"2pzk" }, { "sim":50.0, - "partner":"2pzk" + "partner":"2pzl" }, { "sim":50.0, - "partner":"2pzl" + "partner":"2pzm" }, { "sim":50.0, @@ -143111,10 +143453,6 @@ "sim":50.0, "partner":"4rq9" }, - { - "sim":50.0, - "partner":"5l9l" - }, { "sim":50.0, "partner":"4h3k" @@ -143143,6 +143481,10 @@ "sim":50.0, "partner":"5l9i" }, + { + "sim":50.0, + "partner":"5l9l" + }, { "sim":50.0, "partner":"3esw" @@ -143215,10 +143557,6 @@ "sim":50.0, "partner":"3kzk" }, - { - "sim":50.0, - "partner":"4m1i" - }, { "sim":50.0, "partner":"4d8f" @@ -143231,6 +143569,10 @@ "sim":50.0, "partner":"4m1h" }, + { + "sim":50.0, + "partner":"4m1i" + }, { "sim":50.0, "partner":"2b61" @@ -143271,14 +143613,6 @@ "sim":50.0, "partner":"4ocv" }, - { - "sim":50.0, - "partner":"4q3r" - }, - { - "sim":50.0, - "partner":"4q42" - }, { "sim":50.0, "partner":"4q3s" @@ -143313,19 +143647,23 @@ }, { "sim":50.0, - "partner":"3o2t" + "partner":"4q3r" }, { "sim":50.0, - "partner":"3bu7" + "partner":"4q42" }, { "sim":50.0, - "partner":"2xyo" + "partner":"3o2t" }, { "sim":50.0, - "partner":"4hcl" + "partner":"3bu7" + }, + { + "sim":50.0, + "partner":"2xyo" }, { "sim":50.0, @@ -143339,6 +143677,10 @@ "sim":50.0, "partner":"3au7" }, + { + "sim":50.0, + "partner":"4hcl" + }, { "sim":50.0, "partner":"4r9v" @@ -143369,11 +143711,11 @@ }, { "sim":50.0, - "partner":"3wkr" + "partner":"3wks" }, { "sim":50.0, - "partner":"3wks" + "partner":"3wkr" }, { "sim":50.0, @@ -143381,15 +143723,15 @@ }, { "sim":50.0, - "partner":"4euh" + "partner":"4eue" }, { "sim":50.0, - "partner":"4eue" + "partner":"4euf" }, { "sim":50.0, - "partner":"4euf" + "partner":"4euh" }, { "sim":50.0, @@ -143415,17 +143757,13 @@ "sim":50.0, "partner":"2alm" }, - { - "sim":50.0, - "partner":"2yhg" - }, { "sim":50.0, "partner":"4doy" }, { "sim":50.0, - "partner":"3amu" + "partner":"2yhg" }, { "sim":50.0, @@ -143433,11 +143771,11 @@ }, { "sim":50.0, - "partner":"2yjn" + "partner":"3amu" }, { "sim":50.0, - "partner":"2r98" + "partner":"2yjn" }, { "sim":50.0, @@ -143459,6 +143797,10 @@ "sim":50.0, "partner":"4i49" }, + { + "sim":50.0, + "partner":"2r98" + }, { "sim":50.0, "partner":"3qfs" @@ -143523,10 +143865,6 @@ "sim":50.0, "partner":"4tmu" }, - { - "sim":50.0, - "partner":"2r0p" - }, { "sim":50.0, "partner":"2r0c" @@ -143549,12 +143887,16 @@ }, { "sim":50.0, - "partner":"5ess" + "partner":"2r0p" }, { "sim":50.0, "partner":"5esd" }, + { + "sim":50.0, + "partner":"5ess" + }, { "sim":50.0, "partner":"5esu" @@ -143583,17 +143925,13 @@ "sim":50.0, "partner":"3fjo" }, - { - "sim":50.0, - "partner":"4gyk" - }, { "sim":50.0, "partner":"4gyj" }, { "sim":50.0, - "partner":"2fw3" + "partner":"4gyk" }, { "sim":50.0, @@ -143615,6 +143953,10 @@ "sim":50.0, "partner":"4eph" }, + { + "sim":50.0, + "partner":"2fw3" + }, { "sim":50.0, "partner":"2bpo" @@ -143772,96 +144114,96 @@ ], "subtitle":"T3284 loop variant of beta1", "tags":[ - "synthetic protein", "de novo protein", - "loop design" + "loop design", + "synthetic protein" ], "keywords":[ - "domain", - "matches", - "use", - "designed", - "goals", - "basic", - "repetitive", - "experimentally", - "crystal", - "target", - "based", - "synthetic", - "conformation", - "structure", - "repeat", - "computationally", - "however", - "nanotechnology", - "without", - "pentapeptide", - "incorrect", - "proteins", - "solved", - "de", - "family", - "variants", - "ability", - "chemically", - "better", - "simplifying", - "onto", - "structures", - "construct", - "atomic", - "intrinsically", - "loops", - "large", - "globular", "resolution", - "class", - "fragments", - "closely", - "shown", - "unit", - "design", - "core", - "unsolved", "key", + "repeat", "clearly", - "known", + "generalized", + "intrinsically", + "core", + "precision", "appeared", - "designs", - "one", - "approach", - "showing", - "also", + "unsolved", + "folding", + "goals", + "protein", + "globular", + "simplifying", "novo", - "insertions", - "length", + "domains", "inserting", + "two", "offer", + "crystal", "attractive", - "biologically", - "modular", - "generalized", + "conformation", + "however", + "computationally", + "experimentally", + "family", + "level", + "matches", + "nanotechnology", + "approach", + "showing", + "proteins", + "large", "constructed", - "precision", - "understood", - "extension", - "two", - "problem", + "use", + "modular", "scaffold", - "domains", - "synthesized", - "protein", - "backbone", - "projecting", - "hairpin", + "pentapeptide", + "construct", "computational", + "design", + "onto", + "atomic", + "length", "accommodate", - "folding", + "loops", + "incorrect", + "resolved", + "domain", + "also", + "projecting", + "chemically", + "shown", + "understood", + "backbone", + "ability", + "solved", + "insertions", "developed", + "designed", + "basic", + "one", "loop", - "level", - "resolved" + "variants", + "extension", + "structures", + "de", + "fragments", + "synthesized", + "based", + "hairpin", + "without", + "structure", + "synthetic", + "repetitive", + "closely", + "target", + "biologically", + "known", + "class", + "unit", + "problem", + "designs", + "better" ], "release_date":"2016-08-31", "publication":"\"Synthetic beta-solenoid proteins with the fragment-free computational design of a beta-hairpin extension\", Proc.Natl.Acad.Sci.USA, 113, 10346-10351", @@ -143910,11 +144252,11 @@ }, { "sim":413.0, - "partner":"5dzb" + "partner":"4yfo" }, { "sim":413.0, - "partner":"4yfo" + "partner":"5dzb" }, { "sim":375.0, @@ -143992,27 +144334,27 @@ }, { "sim":57.0, - "partner":"4evc" + "partner":"3ta8" }, { "sim":57.0, - "partner":"4evd" + "partner":"3t9j" }, { "sim":57.0, - "partner":"4eve" + "partner":"4evb" }, { "sim":57.0, - "partner":"3ta8" + "partner":"4evc" }, { "sim":57.0, - "partner":"3t9j" + "partner":"4evd" }, { "sim":57.0, - "partner":"4evb" + "partner":"4eve" }, { "sim":57.0, @@ -144090,10 +144432,6 @@ "sim":55.0, "partner":"2rim" }, - { - "sim":54.0, - "partner":"3rg6" - }, { "sim":54.0, "partner":"2wvw" @@ -144106,6 +144444,10 @@ "sim":54.0, "partner":"2peo" }, + { + "sim":54.0, + "partner":"3rg6" + }, { "sim":54.0, "partner":"3ffl" @@ -144158,10 +144500,6 @@ "sim":54.0, "partner":"3i8v" }, - { - "sim":54.0, - "partner":"4d2w" - }, { "sim":54.0, "partner":"4d2p" @@ -144194,6 +144532,10 @@ "sim":54.0, "partner":"4d2v" }, + { + "sim":54.0, + "partner":"4d2w" + }, { "sim":54.0, "partner":"5eqn" @@ -144276,7 +144618,19 @@ }, { "sim":53.0, - "partner":"4rtl" + "partner":"8rwr" + }, + { + "sim":53.0, + "partner":"8rws" + }, + { + "sim":53.0, + "partner":"8rwo" + }, + { + "sim":53.0, + "partner":"8rwp" }, { "sim":53.0, @@ -144320,7 +144674,7 @@ }, { "sim":53.0, - "partner":"3ws7" + "partner":"4rtl" }, { "sim":53.0, @@ -144332,11 +144686,7 @@ }, { "sim":53.0, - "partner":"4h2w" - }, - { - "sim":53.0, - "partner":"3mey" + "partner":"3ws7" }, { "sim":53.0, @@ -144374,6 +144724,14 @@ "sim":53.0, "partner":"4h2v" }, + { + "sim":53.0, + "partner":"4h2w" + }, + { + "sim":53.0, + "partner":"3mey" + }, { "sim":53.0, "partner":"1v33" @@ -144442,10 +144800,6 @@ "sim":52.0, "partner":"4xbk" }, - { - "sim":52.0, - "partner":"4yvk" - }, { "sim":52.0, "partner":"4yqd" @@ -144470,6 +144824,10 @@ "sim":52.0, "partner":"4yvj" }, + { + "sim":52.0, + "partner":"4yvk" + }, { "sim":52.0, "partner":"1uaj" @@ -144606,10 +144964,6 @@ "sim":52.0, "partner":"4buc" }, - { - "sim":52.0, - "partner":"2q5l" - }, { "sim":52.0, "partner":"2q5o" @@ -144626,6 +144980,10 @@ "sim":52.0, "partner":"2q5j" }, + { + "sim":52.0, + "partner":"2q5l" + }, { "sim":52.0, "partner":"5d6r" @@ -144694,10 +145052,6 @@ "sim":51.0, "partner":"4lfn" }, - { - "sim":51.0, - "partner":"2vbq" - }, { "sim":51.0, "partner":"1s3z" @@ -144710,6 +145064,10 @@ "sim":51.0, "partner":"1s60" }, + { + "sim":51.0, + "partner":"2vbq" + }, { "sim":51.0, "partner":"1u1z" @@ -144766,10 +145124,6 @@ "sim":51.0, "partner":"3ofv" }, - { - "sim":51.0, - "partner":"5bnq" - }, { "sim":51.0, "partner":"3me2" @@ -144780,12 +145134,16 @@ }, { "sim":51.0, - "partner":"3oci" + "partner":"5bnq" }, { "sim":51.0, "partner":"3oc3" }, + { + "sim":51.0, + "partner":"3oci" + }, { "sim":51.0, "partner":"1upi" @@ -144832,15 +145190,15 @@ }, { "sim":51.0, - "partner":"4be6" + "partner":"4bei" }, { "sim":51.0, - "partner":"4bei" + "partner":"4be5" }, { "sim":51.0, - "partner":"4be5" + "partner":"4be6" }, { "sim":51.0, @@ -144868,31 +145226,31 @@ }, { "sim":51.0, - "partner":"3quo" + "partner":"3qur" }, { "sim":51.0, - "partner":"3qvf" + "partner":"3qvh" }, { "sim":51.0, - "partner":"3qur" + "partner":"3d40" }, { "sim":51.0, - "partner":"3qvh" + "partner":"3d41" }, { "sim":51.0, - "partner":"3d40" + "partner":"3qun" }, { "sim":51.0, - "partner":"3d41" + "partner":"3quo" }, { "sim":51.0, - "partner":"3qun" + "partner":"3qvf" }, { "sim":51.0, @@ -144912,27 +145270,27 @@ }, { "sim":51.0, - "partner":"3g3d" + "partner":"3bvj" }, { "sim":51.0, - "partner":"5a7y" + "partner":"3mw7" }, { "sim":51.0, - "partner":"3bvj" + "partner":"4hib" }, { "sim":51.0, - "partner":"3mw7" + "partner":"4hkp" }, { "sim":51.0, - "partner":"4hib" + "partner":"3g3d" }, { "sim":51.0, - "partner":"4hkp" + "partner":"5a7y" }, { "sim":51.0, @@ -144976,43 +145334,43 @@ }, { "sim":51.0, - "partner":"3sie" + "partner":"4i9z" }, { "sim":51.0, - "partner":"4g2w" + "partner":"4ia0" }, { "sim":51.0, - "partner":"4g2y" + "partner":"4l3f" }, { "sim":51.0, - "partner":"4i9z" + "partner":"4oew" }, { "sim":51.0, - "partner":"4ia0" + "partner":"4oex" }, { "sim":51.0, - "partner":"4l3f" + "partner":"3shy" }, { "sim":51.0, - "partner":"4oew" + "partner":"3shz" }, { "sim":51.0, - "partner":"4oex" + "partner":"3sie" }, { "sim":51.0, - "partner":"3shy" + "partner":"4g2w" }, { "sim":51.0, - "partner":"3shz" + "partner":"4g2y" }, { "sim":51.0, @@ -145042,10 +145400,6 @@ "sim":51.0, "partner":"3wxm" }, - { - "sim":51.0, - "partner":"3c1y" - }, { "sim":51.0, "partner":"3c1z" @@ -145070,6 +145424,10 @@ "sim":51.0, "partner":"4yxm" }, + { + "sim":51.0, + "partner":"3c1y" + }, { "sim":51.0, "partner":"2rjg" @@ -145118,10 +145476,6 @@ "sim":51.0, "partner":"3vvm" }, - { - "sim":51.0, - "partner":"2y6r" - }, { "sim":51.0, "partner":"4a99" @@ -145142,6 +145496,10 @@ "sim":51.0, "partner":"2y6q" }, + { + "sim":51.0, + "partner":"2y6r" + }, { "sim":51.0, "partner":"3k01" @@ -145202,10 +145560,6 @@ "sim":51.0, "partner":"4lf2" }, - { - "sim":51.0, - "partner":"4cdm" - }, { "sim":51.0, "partner":"4cdn" @@ -145218,6 +145572,10 @@ "sim":51.0, "partner":"2xrz" }, + { + "sim":51.0, + "partner":"4cdm" + }, { "sim":51.0, "partner":"3ug3" @@ -145246,10 +145604,6 @@ "sim":51.0, "partner":"3qfb" }, - { - "sim":51.0, - "partner":"2cj9" - }, { "sim":51.0, "partner":"2cja" @@ -145262,6 +145616,10 @@ "sim":51.0, "partner":"2cjb" }, + { + "sim":51.0, + "partner":"2cj9" + }, { "sim":51.0, "partner":"4s21" @@ -145344,11 +145702,11 @@ }, { "sim":50.0, - "partner":"3gz2" + "partner":"4oml" }, { "sim":50.0, - "partner":"4oml" + "partner":"3gz2" }, { "sim":50.0, @@ -145416,15 +145774,15 @@ }, { "sim":50.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":50.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":50.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":50.0, @@ -145460,15 +145818,15 @@ }, { "sim":50.0, - "partner":"3sw1" + "partner":"5j3w" }, { "sim":50.0, - "partner":"5j3w" + "partner":"5j4e" }, { "sim":50.0, - "partner":"5j4e" + "partner":"3sw1" }, { "sim":50.0, @@ -145484,11 +145842,11 @@ }, { "sim":50.0, - "partner":"2ela" + "partner":"2b6b" }, { "sim":50.0, - "partner":"2b6b" + "partner":"2ela" }, { "sim":50.0, @@ -145528,11 +145886,11 @@ }, { "sim":50.0, - "partner":"4kce" + "partner":"2h66" }, { "sim":50.0, - "partner":"2h66" + "partner":"4kce" }, { "sim":50.0, @@ -145548,11 +145906,11 @@ }, { "sim":50.0, - "partner":"4jr4" + "partner":"4jr6" }, { "sim":50.0, - "partner":"4jr6" + "partner":"4jr4" }, { "sim":50.0, @@ -145580,15 +145938,15 @@ }, { "sim":50.0, - "partner":"3la7" + "partner":"3la2" }, { "sim":50.0, - "partner":"3la2" + "partner":"3la3" }, { "sim":50.0, - "partner":"3la3" + "partner":"3la7" }, { "sim":50.0, @@ -145602,10 +145960,6 @@ "sim":50.0, "partner":"2rde" }, - { - "sim":50.0, - "partner":"4da6" - }, { "sim":50.0, "partner":"4da7" @@ -145658,6 +146012,10 @@ "sim":50.0, "partner":"4d8v" }, + { + "sim":50.0, + "partner":"4da6" + }, { "sim":50.0, "partner":"2yfa" @@ -145672,15 +146030,15 @@ }, { "sim":50.0, - "partner":"1zw3" + "partner":"1zvz" }, { "sim":50.0, - "partner":"1zvz" + "partner":"1zw2" }, { "sim":50.0, - "partner":"1zw2" + "partner":"1zw3" }, { "sim":50.0, @@ -145694,10 +146052,6 @@ "sim":50.0, "partner":"2jfq" }, - { - "sim":50.0, - "partner":"4rdh" - }, { "sim":50.0, "partner":"4rdi" @@ -145722,6 +146076,10 @@ "sim":50.0, "partner":"5djj" }, + { + "sim":50.0, + "partner":"4rdh" + }, { "sim":50.0, "partner":"5djk" @@ -145740,11 +146098,11 @@ }, { "sim":50.0, - "partner":"3ta4" + "partner":"3t9w" }, { "sim":50.0, - "partner":"3t9w" + "partner":"3ta4" }, { "sim":50.0, @@ -145756,19 +146114,19 @@ }, { "sim":50.0, - "partner":"3nha" + "partner":"3nh6" }, { "sim":50.0, - "partner":"3nhb" + "partner":"3nh9" }, { "sim":50.0, - "partner":"3nh6" + "partner":"3nha" }, { "sim":50.0, - "partner":"3nh9" + "partner":"3nhb" }, { "sim":50.0, @@ -145784,31 +146142,31 @@ }, { "sim":50.0, - "partner":"3ggo" + "partner":"3ggp" }, { "sim":50.0, - "partner":"3ggp" + "partner":"3ggg" }, { "sim":50.0, - "partner":"3ggg" + "partner":"3ggo" }, { "sim":50.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":50.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":50.0, - "partner":"3tm8" + "partner":"3tmc" }, { "sim":50.0, - "partner":"3tmb" + "partner":"3tmd" }, { "sim":50.0, @@ -145820,15 +146178,15 @@ }, { "sim":50.0, - "partner":"2pzm" + "partner":"2pzk" }, { "sim":50.0, - "partner":"2pzk" + "partner":"2pzl" }, { "sim":50.0, - "partner":"2pzl" + "partner":"2pzm" }, { "sim":50.0, @@ -145942,10 +146300,6 @@ "sim":50.0, "partner":"3kzk" }, - { - "sim":50.0, - "partner":"4m1i" - }, { "sim":50.0, "partner":"4d8f" @@ -145958,6 +146312,10 @@ "sim":50.0, "partner":"4m1h" }, + { + "sim":50.0, + "partner":"4m1i" + }, { "sim":50.0, "partner":"5f8c" @@ -145994,14 +146352,6 @@ "sim":50.0, "partner":"4ocv" }, - { - "sim":50.0, - "partner":"4q3r" - }, - { - "sim":50.0, - "partner":"4q42" - }, { "sim":50.0, "partner":"4q3s" @@ -146034,6 +146384,14 @@ "sim":50.0, "partner":"4q41" }, + { + "sim":50.0, + "partner":"4q3r" + }, + { + "sim":50.0, + "partner":"4q42" + }, { "sim":50.0, "partner":"3o2t" @@ -146050,10 +146408,6 @@ "sim":50.0, "partner":"2xyo" }, - { - "sim":50.0, - "partner":"4hcl" - }, { "sim":50.0, "partner":"4hcd" @@ -146066,6 +146420,10 @@ "sim":50.0, "partner":"3au7" }, + { + "sim":50.0, + "partner":"4hcl" + }, { "sim":50.0, "partner":"4r9v" @@ -146094,17 +146452,13 @@ "sim":50.0, "partner":"3kki" }, - { - "sim":50.0, - "partner":"2gqn" - }, { "sim":50.0, "partner":"2fq6" }, { "sim":50.0, - "partner":"3wkr" + "partner":"2gqn" }, { "sim":50.0, @@ -146112,11 +146466,11 @@ }, { "sim":50.0, - "partner":"4bko" + "partner":"3wkr" }, { "sim":50.0, - "partner":"4euh" + "partner":"4bko" }, { "sim":50.0, @@ -146126,6 +146480,10 @@ "sim":50.0, "partner":"4euf" }, + { + "sim":50.0, + "partner":"4euh" + }, { "sim":50.0, "partner":"5ec4" @@ -146150,17 +146508,13 @@ "sim":50.0, "partner":"2alm" }, - { - "sim":50.0, - "partner":"2yhg" - }, { "sim":50.0, "partner":"4doy" }, { "sim":50.0, - "partner":"3amu" + "partner":"2yhg" }, { "sim":50.0, @@ -146168,11 +146522,11 @@ }, { "sim":50.0, - "partner":"2yjn" + "partner":"3amu" }, { "sim":50.0, - "partner":"2r98" + "partner":"2yjn" }, { "sim":50.0, @@ -146194,6 +146548,10 @@ "sim":50.0, "partner":"4i49" }, + { + "sim":50.0, + "partner":"2r98" + }, { "sim":50.0, "partner":"3qfs" @@ -146258,10 +146616,6 @@ "sim":50.0, "partner":"4tmu" }, - { - "sim":50.0, - "partner":"2r0p" - }, { "sim":50.0, "partner":"2r0c" @@ -146284,12 +146638,16 @@ }, { "sim":50.0, - "partner":"5ess" + "partner":"2r0p" }, { "sim":50.0, "partner":"5esd" }, + { + "sim":50.0, + "partner":"5ess" + }, { "sim":50.0, "partner":"5esu" @@ -146318,17 +146676,13 @@ "sim":50.0, "partner":"3fjo" }, - { - "sim":50.0, - "partner":"4gyk" - }, { "sim":50.0, "partner":"4gyj" }, { "sim":50.0, - "partner":"2fw3" + "partner":"4gyk" }, { "sim":50.0, @@ -146350,6 +146704,10 @@ "sim":50.0, "partner":"4eph" }, + { + "sim":50.0, + "partner":"2fw3" + }, { "sim":50.0, "partner":"2bpo" @@ -146495,96 +146853,96 @@ ], "subtitle":"T3284 loop variant of beta1", "tags":[ - "synthetic protein", "de novo protein", - "loop design" + "loop design", + "synthetic protein" ], "keywords":[ - "domain", - "matches", - "use", - "designed", - "goals", - "basic", - "repetitive", - "experimentally", - "crystal", - "target", - "based", - "synthetic", - "conformation", - "structure", - "repeat", - "computationally", - "however", - "nanotechnology", - "without", - "pentapeptide", - "incorrect", - "proteins", - "solved", - "de", - "family", - "variants", - "ability", - "chemically", - "better", - "simplifying", - "onto", - "structures", - "construct", - "atomic", - "intrinsically", - "loops", - "large", - "globular", "resolution", - "class", - "fragments", - "closely", - "shown", - "unit", - "design", - "core", - "unsolved", "key", + "repeat", "clearly", - "known", + "generalized", + "intrinsically", + "core", + "precision", "appeared", - "designs", - "one", - "approach", - "showing", - "also", + "unsolved", + "folding", + "goals", + "protein", + "globular", + "simplifying", "novo", - "insertions", - "length", + "domains", "inserting", + "two", "offer", + "crystal", "attractive", - "biologically", - "modular", - "generalized", + "conformation", + "however", + "computationally", + "experimentally", + "family", + "level", + "matches", + "nanotechnology", + "approach", + "showing", + "proteins", + "large", "constructed", - "precision", - "understood", - "extension", - "two", - "problem", + "use", + "modular", "scaffold", - "domains", - "synthesized", - "protein", - "backbone", - "projecting", - "hairpin", + "pentapeptide", + "construct", "computational", + "design", + "onto", + "atomic", + "length", "accommodate", - "folding", + "loops", + "incorrect", + "resolved", + "domain", + "also", + "projecting", + "chemically", + "shown", + "understood", + "backbone", + "ability", + "solved", + "insertions", "developed", + "designed", + "basic", + "one", "loop", - "level", - "resolved" + "variants", + "extension", + "structures", + "de", + "fragments", + "synthesized", + "based", + "hairpin", + "without", + "structure", + "synthetic", + "repetitive", + "closely", + "target", + "biologically", + "known", + "class", + "unit", + "problem", + "designs", + "better" ], "release_date":"2016-08-31", "publication":"\"Synthetic beta-solenoid proteins with the fragment-free computational design of a beta-hairpin extension\", Proc.Natl.Acad.Sci.USA, 113, 10346-10351", @@ -146621,11 +146979,11 @@ }, { "sim":396.0, - "partner":"5dzb" + "partner":"4yfo" }, { "sim":396.0, - "partner":"4yfo" + "partner":"5dzb" }, { "sim":376.0, @@ -146715,27 +147073,27 @@ }, { "sim":57.0, - "partner":"4evc" + "partner":"3ta8" }, { "sim":57.0, - "partner":"4evd" + "partner":"3t9j" }, { "sim":57.0, - "partner":"4eve" + "partner":"4evb" }, { "sim":57.0, - "partner":"3ta8" + "partner":"4evc" }, { "sim":57.0, - "partner":"3t9j" + "partner":"4evd" }, { "sim":57.0, - "partner":"4evb" + "partner":"4eve" }, { "sim":57.0, @@ -146793,10 +147151,6 @@ "sim":55.0, "partner":"3nd1" }, - { - "sim":55.0, - "partner":"4d2w" - }, { "sim":55.0, "partner":"4d2p" @@ -146831,11 +147185,11 @@ }, { "sim":55.0, - "partner":"2rim" + "partner":"4d2w" }, { - "sim":54.0, - "partner":"3rg6" + "sim":55.0, + "partner":"2rim" }, { "sim":54.0, @@ -146849,6 +147203,10 @@ "sim":54.0, "partner":"2peo" }, + { + "sim":54.0, + "partner":"3rg6" + }, { "sim":54.0, "partner":"3ffl" @@ -146977,10 +147335,6 @@ "sim":53.0, "partner":"2ews" }, - { - "sim":53.0, - "partner":"4rtl" - }, { "sim":53.0, "partner":"4rtm" @@ -147023,7 +147377,7 @@ }, { "sim":53.0, - "partner":"3ws7" + "partner":"4rtl" }, { "sim":53.0, @@ -147035,11 +147389,7 @@ }, { "sim":53.0, - "partner":"4h2w" - }, - { - "sim":53.0, - "partner":"3mey" + "partner":"3ws7" }, { "sim":53.0, @@ -147077,6 +147427,14 @@ "sim":53.0, "partner":"4h2v" }, + { + "sim":53.0, + "partner":"4h2w" + }, + { + "sim":53.0, + "partner":"3mey" + }, { "sim":53.0, "partner":"4rq9" @@ -147157,10 +147515,6 @@ "sim":52.0, "partner":"4p6c" }, - { - "sim":52.0, - "partner":"4yvk" - }, { "sim":52.0, "partner":"4yqd" @@ -147185,6 +147539,10 @@ "sim":52.0, "partner":"4yvj" }, + { + "sim":52.0, + "partner":"4yvk" + }, { "sim":52.0, "partner":"1uaj" @@ -147329,10 +147687,6 @@ "sim":52.0, "partner":"3s7y" }, - { - "sim":52.0, - "partner":"2q5l" - }, { "sim":52.0, "partner":"2q5o" @@ -147349,6 +147703,10 @@ "sim":52.0, "partner":"2q5j" }, + { + "sim":52.0, + "partner":"2q5l" + }, { "sim":52.0, "partner":"5d6r" @@ -147429,10 +147787,6 @@ "sim":51.0, "partner":"4lfn" }, - { - "sim":51.0, - "partner":"2vbq" - }, { "sim":51.0, "partner":"1s3z" @@ -147445,6 +147799,10 @@ "sim":51.0, "partner":"1s60" }, + { + "sim":51.0, + "partner":"2vbq" + }, { "sim":51.0, "partner":"2znz" @@ -147505,10 +147863,6 @@ "sim":51.0, "partner":"3ofv" }, - { - "sim":51.0, - "partner":"5bnq" - }, { "sim":51.0, "partner":"3me2" @@ -147519,12 +147873,16 @@ }, { "sim":51.0, - "partner":"3oci" + "partner":"5bnq" }, { "sim":51.0, "partner":"3oc3" }, + { + "sim":51.0, + "partner":"3oci" + }, { "sim":51.0, "partner":"1upi" @@ -147563,11 +147921,11 @@ }, { "sim":51.0, - "partner":"3rpu" + "partner":"8tlb" }, { "sim":51.0, - "partner":"8tlb" + "partner":"3rpu" }, { "sim":51.0, @@ -147575,15 +147933,15 @@ }, { "sim":51.0, - "partner":"4be6" + "partner":"4bei" }, { "sim":51.0, - "partner":"4bei" + "partner":"4be5" }, { "sim":51.0, - "partner":"4be5" + "partner":"4be6" }, { "sim":51.0, @@ -147613,6 +147971,22 @@ "sim":51.0, "partner":"8rwq" }, + { + "sim":51.0, + "partner":"8rwr" + }, + { + "sim":51.0, + "partner":"8rws" + }, + { + "sim":51.0, + "partner":"8rwo" + }, + { + "sim":51.0, + "partner":"8rwp" + }, { "sim":51.0, "partner":"3et1" @@ -147639,27 +148013,27 @@ }, { "sim":51.0, - "partner":"3g3d" + "partner":"3bvj" }, { "sim":51.0, - "partner":"5a7y" + "partner":"3mw7" }, { "sim":51.0, - "partner":"3bvj" + "partner":"4hib" }, { "sim":51.0, - "partner":"3mw7" + "partner":"4hkp" }, { "sim":51.0, - "partner":"4hib" + "partner":"3g3d" }, { "sim":51.0, - "partner":"4hkp" + "partner":"5a7y" }, { "sim":51.0, @@ -147703,39 +148077,39 @@ }, { "sim":51.0, - "partner":"3sie" + "partner":"4i9z" }, { "sim":51.0, - "partner":"4g2w" + "partner":"4ia0" }, { "sim":51.0, - "partner":"4g2y" + "partner":"4oew" }, { "sim":51.0, - "partner":"4i9z" + "partner":"4oex" }, { "sim":51.0, - "partner":"4ia0" + "partner":"3shy" }, { "sim":51.0, - "partner":"4oew" + "partner":"3shz" }, { "sim":51.0, - "partner":"4oex" + "partner":"3sie" }, { "sim":51.0, - "partner":"3shy" + "partner":"4g2w" }, { "sim":51.0, - "partner":"3shz" + "partner":"4g2y" }, { "sim":51.0, @@ -147765,10 +148139,6 @@ "sim":51.0, "partner":"3wxm" }, - { - "sim":51.0, - "partner":"3c1y" - }, { "sim":51.0, "partner":"3c1z" @@ -147793,6 +148163,10 @@ "sim":51.0, "partner":"4yxm" }, + { + "sim":51.0, + "partner":"3c1y" + }, { "sim":51.0, "partner":"2rjg" @@ -147845,10 +148219,6 @@ "sim":51.0, "partner":"5awm" }, - { - "sim":51.0, - "partner":"2y6r" - }, { "sim":51.0, "partner":"4a99" @@ -147869,6 +148239,10 @@ "sim":51.0, "partner":"2y6q" }, + { + "sim":51.0, + "partner":"2y6r" + }, { "sim":51.0, "partner":"3k01" @@ -147913,10 +148287,6 @@ "sim":51.0, "partner":"4lf2" }, - { - "sim":51.0, - "partner":"4cdm" - }, { "sim":51.0, "partner":"4cdn" @@ -147929,6 +148299,10 @@ "sim":51.0, "partner":"2xrz" }, + { + "sim":51.0, + "partner":"4cdm" + }, { "sim":51.0, "partner":"3ug3" @@ -147957,10 +148331,6 @@ "sim":51.0, "partner":"3qfb" }, - { - "sim":51.0, - "partner":"2cj9" - }, { "sim":51.0, "partner":"2cja" @@ -147973,6 +148343,10 @@ "sim":51.0, "partner":"2cjb" }, + { + "sim":51.0, + "partner":"2cj9" + }, { "sim":51.0, "partner":"4s21" @@ -148019,11 +148393,11 @@ }, { "sim":50.0, - "partner":"3gz2" + "partner":"4oml" }, { "sim":50.0, - "partner":"4oml" + "partner":"3gz2" }, { "sim":50.0, @@ -148087,15 +148461,15 @@ }, { "sim":50.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":50.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":50.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":50.0, @@ -148123,15 +148497,15 @@ }, { "sim":50.0, - "partner":"3sw1" + "partner":"5j3w" }, { "sim":50.0, - "partner":"5j3w" + "partner":"5j4e" }, { "sim":50.0, - "partner":"5j4e" + "partner":"3sw1" }, { "sim":50.0, @@ -148151,11 +148525,11 @@ }, { "sim":50.0, - "partner":"2ela" + "partner":"2b6b" }, { "sim":50.0, - "partner":"2b6b" + "partner":"2ela" }, { "sim":50.0, @@ -148191,11 +148565,11 @@ }, { "sim":50.0, - "partner":"4kce" + "partner":"2h66" }, { "sim":50.0, - "partner":"2h66" + "partner":"4kce" }, { "sim":50.0, @@ -148211,11 +148585,11 @@ }, { "sim":50.0, - "partner":"4jr4" + "partner":"4jr6" }, { "sim":50.0, - "partner":"4jr6" + "partner":"4jr4" }, { "sim":50.0, @@ -148241,10 +148615,6 @@ "sim":50.0, "partner":"2fz4" }, - { - "sim":50.0, - "partner":"3la7" - }, { "sim":50.0, "partner":"3la2" @@ -148255,15 +148625,15 @@ }, { "sim":50.0, - "partner":"3r6s" + "partner":"3la7" }, { "sim":50.0, - "partner":"2rde" + "partner":"3r6s" }, { "sim":50.0, - "partner":"4da6" + "partner":"2rde" }, { "sim":50.0, @@ -148317,6 +148687,10 @@ "sim":50.0, "partner":"4d8v" }, + { + "sim":50.0, + "partner":"4da6" + }, { "sim":50.0, "partner":"2yfa" @@ -148331,15 +148705,15 @@ }, { "sim":50.0, - "partner":"1zw3" + "partner":"1zvz" }, { "sim":50.0, - "partner":"1zvz" + "partner":"1zw2" }, { "sim":50.0, - "partner":"1zw2" + "partner":"1zw3" }, { "sim":50.0, @@ -148353,10 +148727,6 @@ "sim":50.0, "partner":"2jfq" }, - { - "sim":50.0, - "partner":"4rdh" - }, { "sim":50.0, "partner":"4rdi" @@ -148381,6 +148751,10 @@ "sim":50.0, "partner":"5djj" }, + { + "sim":50.0, + "partner":"4rdh" + }, { "sim":50.0, "partner":"5djk" @@ -148399,11 +148773,11 @@ }, { "sim":50.0, - "partner":"3ta4" + "partner":"3t9w" }, { "sim":50.0, - "partner":"3t9w" + "partner":"3ta4" }, { "sim":50.0, @@ -148415,19 +148789,19 @@ }, { "sim":50.0, - "partner":"3nha" + "partner":"3nh6" }, { "sim":50.0, - "partner":"3nhb" + "partner":"3nh9" }, { "sim":50.0, - "partner":"3nh6" + "partner":"3nha" }, { "sim":50.0, - "partner":"3nh9" + "partner":"3nhb" }, { "sim":50.0, @@ -148435,31 +148809,31 @@ }, { "sim":50.0, - "partner":"3ggo" + "partner":"3ggp" }, { "sim":50.0, - "partner":"3ggp" + "partner":"3ggg" }, { "sim":50.0, - "partner":"3ggg" + "partner":"3ggo" }, { "sim":50.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":50.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":50.0, - "partner":"3tm8" + "partner":"3tmc" }, { "sim":50.0, - "partner":"3tmb" + "partner":"3tmd" }, { "sim":50.0, @@ -148471,15 +148845,15 @@ }, { "sim":50.0, - "partner":"2pzm" + "partner":"2pzk" }, { "sim":50.0, - "partner":"2pzk" + "partner":"2pzl" }, { "sim":50.0, - "partner":"2pzl" + "partner":"2pzm" }, { "sim":50.0, @@ -148597,10 +148971,6 @@ "sim":50.0, "partner":"3kzk" }, - { - "sim":50.0, - "partner":"4m1i" - }, { "sim":50.0, "partner":"4d8f" @@ -148613,6 +148983,10 @@ "sim":50.0, "partner":"4m1h" }, + { + "sim":50.0, + "partner":"4m1i" + }, { "sim":50.0, "partner":"2b61" @@ -148653,14 +149027,6 @@ "sim":50.0, "partner":"4ocv" }, - { - "sim":50.0, - "partner":"4q3r" - }, - { - "sim":50.0, - "partner":"4q42" - }, { "sim":50.0, "partner":"4q3s" @@ -148695,19 +149061,23 @@ }, { "sim":50.0, - "partner":"3o2t" + "partner":"4q3r" }, { "sim":50.0, - "partner":"3bu7" + "partner":"4q42" }, { "sim":50.0, - "partner":"2xyo" + "partner":"3o2t" }, { "sim":50.0, - "partner":"4hcl" + "partner":"3bu7" + }, + { + "sim":50.0, + "partner":"2xyo" }, { "sim":50.0, @@ -148721,6 +149091,10 @@ "sim":50.0, "partner":"3au7" }, + { + "sim":50.0, + "partner":"4hcl" + }, { "sim":50.0, "partner":"4r9v" @@ -148751,11 +149125,11 @@ }, { "sim":50.0, - "partner":"3wkr" + "partner":"3wks" }, { "sim":50.0, - "partner":"3wks" + "partner":"3wkr" }, { "sim":50.0, @@ -148763,15 +149137,15 @@ }, { "sim":50.0, - "partner":"4euh" + "partner":"4eue" }, { "sim":50.0, - "partner":"4eue" + "partner":"4euf" }, { "sim":50.0, - "partner":"4euf" + "partner":"4euh" }, { "sim":50.0, @@ -148797,17 +149171,13 @@ "sim":50.0, "partner":"2alm" }, - { - "sim":50.0, - "partner":"2yhg" - }, { "sim":50.0, "partner":"4doy" }, { "sim":50.0, - "partner":"3amu" + "partner":"2yhg" }, { "sim":50.0, @@ -148815,11 +149185,11 @@ }, { "sim":50.0, - "partner":"2yjn" + "partner":"3amu" }, { "sim":50.0, - "partner":"2r98" + "partner":"2yjn" }, { "sim":50.0, @@ -148841,6 +149211,10 @@ "sim":50.0, "partner":"4i49" }, + { + "sim":50.0, + "partner":"2r98" + }, { "sim":50.0, "partner":"3qfs" @@ -148905,10 +149279,6 @@ "sim":50.0, "partner":"4tmu" }, - { - "sim":50.0, - "partner":"2r0p" - }, { "sim":50.0, "partner":"2r0c" @@ -148931,12 +149301,16 @@ }, { "sim":50.0, - "partner":"5ess" + "partner":"2r0p" }, { "sim":50.0, "partner":"5esd" }, + { + "sim":50.0, + "partner":"5ess" + }, { "sim":50.0, "partner":"5esu" @@ -148965,17 +149339,13 @@ "sim":50.0, "partner":"3fjo" }, - { - "sim":50.0, - "partner":"4gyk" - }, { "sim":50.0, "partner":"4gyj" }, { "sim":50.0, - "partner":"2fw3" + "partner":"4gyk" }, { "sim":50.0, @@ -148997,6 +149367,10 @@ "sim":50.0, "partner":"4eph" }, + { + "sim":50.0, + "partner":"2fw3" + }, { "sim":50.0, "partner":"2bpo" @@ -149124,84 +149498,84 @@ "protein design" ], "keywords":[ - "work", - "reductase", - "reducing", - "substantially", - "towards", - "determined", - "features", - "reconnect", - "generates", - "structure", - "however", + "templates", "affinity", - "novel", + "whether", + "demonstrates", + "engineering", + "structural", "preserves", + "three", + "methotrexate", + "reconnect", + "new", + "protein", + "integrity", + "topologies", + "databank", + "showed", + "manner", + "removal", + "involved", + "connections", + "similar", + "introduction", + "initial", + "however", + "dhfr", + "exhibited", + "examine", + "reductase", "rearrangement", - "array", - "topology", + "nadph", + "dihydrofolate", "proteins", - "models", - "exhibited", - "similar", + "large", "process", - "involved", - "integrity", - "connections", - "whether", - "manner", - "\u00e5", - "careful", + "success", + "features", + "reducing", "demonstrating", + "pdb", + "rethreaded", + "design", + "topology", + "work", + "expanded", "used", - "demonstrates", + "loops", "yet", - "initial", - "often", - "removal", - "methotrexate", - "structures", - "templates", - "introduction", - "alternate", - "three", - "showed", - "native", + "possible", "properties", - "powerful", - "loops", - "large", + "tool", + "wtdhfr", + "generates", "coli", - "nadph", - "topologies", - "examine", - "activity", - "engineering", - "design", - "dihydrofolate", - "introduce", - "describe", + "careful", "sequence", + "substantially", + "relationship", + "describe", + "rethreading", "desirable", - "wtdhfr", - "structural", + "often", + "models", + "array", + "structures", + "\u00e5", "important", - "lower", - "pdb", - "rethreading", - "success", + "structure", + "introduce", + "alternate", + "determined", + "powerful", "modified", + "towards", + "activity", + "native", "affinities", - "protein", - "databank", - "dhfr", - "relationship", - "rethreaded", - "possible", - "expanded", - "tool", - "new" + "lower", + "novel" ], "release_date":"2016-06-08", "publication":"\"Protein rethreading: A novel approach to protein design\", Sci Rep, 6, 26847-26847", @@ -149243,18 +149617,6 @@ "sim":224.0, "partner":"1dyj" }, - { - "sim":224.0, - "partner":"1rg7" - }, - { - "sim":224.0, - "partner":"2ano" - }, - { - "sim":224.0, - "partner":"3qyl" - }, { "sim":224.0, "partner":"2anq" @@ -149317,7 +149679,7 @@ }, { "sim":224.0, - "partner":"1dre" + "partner":"6dfr" }, { "sim":224.0, @@ -149325,7 +149687,7 @@ }, { "sim":224.0, - "partner":"6dfr" + "partner":"1dre" }, { "sim":224.0, @@ -149339,10 +149701,6 @@ "sim":224.0, "partner":"1rc4" }, - { - "sim":224.0, - "partner":"1drh" - }, { "sim":224.0, "partner":"1ra2" @@ -149355,6 +149713,10 @@ "sim":224.0, "partner":"5dfr" }, + { + "sim":224.0, + "partner":"1drh" + }, { "sim":224.0, "partner":"1rf7" @@ -149365,11 +149727,11 @@ }, { "sim":224.0, - "partner":"1jol" + "partner":"3qyo" }, { "sim":224.0, - "partner":"3qyo" + "partner":"7dfr" }, { "sim":224.0, @@ -149383,17 +149745,13 @@ "sim":224.0, "partner":"4dfr" }, - { - "sim":224.0, - "partner":"1jom" - }, { "sim":224.0, "partner":"1ra9" }, { "sim":224.0, - "partner":"1dyh" + "partner":"1jol" }, { "sim":224.0, @@ -149405,23 +149763,31 @@ }, { "sim":224.0, - "partner":"7dfr" + "partner":"1jom" }, { "sim":224.0, - "partner":"1dyi" + "partner":"1dyh" }, { "sim":224.0, "partner":"3och" }, { - "sim":223.0, - "partner":"4psy" + "sim":224.0, + "partner":"1dyi" }, { - "sim":223.0, - "partner":"4nx6" + "sim":224.0, + "partner":"1rg7" + }, + { + "sim":224.0, + "partner":"2ano" + }, + { + "sim":224.0, + "partner":"3qyl" }, { "sim":223.0, @@ -149449,19 +149815,15 @@ }, { "sim":223.0, - "partner":"1ddr" - }, - { - "sim":223.0, - "partner":"1dds" + "partner":"4p3q" }, { "sim":223.0, - "partner":"4p3q" + "partner":"4pss" }, { "sim":223.0, - "partner":"4pss" + "partner":"1ddr" }, { "sim":223.0, @@ -149483,6 +149845,10 @@ "sim":223.0, "partner":"4kjk" }, + { + "sim":223.0, + "partner":"1dds" + }, { "sim":223.0, "partner":"3dau" @@ -149515,6 +149881,14 @@ "sim":223.0, "partner":"4i1n" }, + { + "sim":223.0, + "partner":"4psy" + }, + { + "sim":223.0, + "partner":"4nx6" + }, { "sim":223.0, "partner":"4kjl" @@ -149593,11 +149967,11 @@ }, { "sim":210.0, - "partner":"4or7" + "partner":"4osg" }, { "sim":210.0, - "partner":"4osg" + "partner":"4or7" }, { "sim":178.0, @@ -149665,28 +150039,24 @@ }, { "sim":86.0, - "partner":"3sa1" + "partner":"3s9u" }, { "sim":86.0, - "partner":"3sai" + "partner":"3sa1" }, { "sim":86.0, - "partner":"3sa2" + "partner":"3sai" }, { "sim":86.0, - "partner":"3s9u" + "partner":"3sa2" }, { "sim":86.0, "partner":"3fl9" }, - { - "sim":86.0, - "partner":"4elh" - }, { "sim":86.0, "partner":"4ele" @@ -149711,6 +150081,10 @@ "sim":86.0, "partner":"4elb" }, + { + "sim":86.0, + "partner":"4elh" + }, { "sim":86.0, "partner":"2kgk" @@ -149863,10 +150237,6 @@ "sim":65.0, "partner":"3i8a" }, - { - "sim":64.0, - "partner":"3f0x" - }, { "sim":64.0, "partner":"3fqv" @@ -149887,6 +150257,10 @@ "sim":64.0, "partner":"3fqo" }, + { + "sim":64.0, + "partner":"3f0x" + }, { "sim":64.0, "partner":"3fra" @@ -149905,11 +150279,11 @@ }, { "sim":64.0, - "partner":"2w9g" + "partner":"2w9h" }, { "sim":64.0, - "partner":"2w9h" + "partner":"2w9g" }, { "sim":64.0, @@ -150021,19 +150395,15 @@ }, { "sim":55.0, - "partner":"1m7a" - }, - { - "sim":55.0, - "partner":"4hoe" + "partner":"4hof" }, { "sim":55.0, - "partner":"4hof" + "partner":"3qlr" }, { "sim":55.0, - "partner":"3qlr" + "partner":"3qls" }, { "sim":55.0, @@ -150047,10 +150417,6 @@ "sim":55.0, "partner":"1ia1" }, - { - "sim":55.0, - "partner":"3qls" - }, { "sim":55.0, "partner":"1ia2" @@ -150076,21 +150442,29 @@ "partner":"1m79" }, { - "sim":53.0, - "partner":"3um6" + "sim":55.0, + "partner":"1m7a" + }, + { + "sim":55.0, + "partner":"4hoe" }, { "sim":53.0, "partner":"3um5" }, { - "sim":51.0, - "partner":"3dga" + "sim":53.0, + "partner":"3um6" }, { "sim":51.0, "partner":"1j3i" }, + { + "sim":51.0, + "partner":"3dga" + }, { "sim":51.0, "partner":"3um8" @@ -150189,96 +150563,96 @@ ], "subtitle":"6beta1", "tags":[ - "synthetic protein", "de novo protein", - "loop design" + "loop design", + "synthetic protein" ], "keywords":[ - "domain", - "matches", - "use", - "designed", - "goals", - "basic", - "repetitive", - "experimentally", - "crystal", - "target", - "based", - "synthetic", - "conformation", - "structure", - "repeat", - "computationally", - "however", - "nanotechnology", - "without", - "pentapeptide", - "incorrect", - "proteins", - "solved", - "de", - "family", - "variants", - "ability", - "chemically", - "better", - "simplifying", - "onto", - "structures", - "construct", - "atomic", - "intrinsically", - "loops", - "large", - "globular", "resolution", - "class", - "fragments", - "closely", - "shown", - "unit", - "design", - "core", - "unsolved", "key", + "repeat", "clearly", - "known", + "generalized", + "intrinsically", + "core", + "precision", "appeared", - "designs", - "one", - "approach", - "showing", - "also", + "unsolved", + "folding", + "goals", + "protein", + "globular", + "simplifying", "novo", - "insertions", - "length", + "domains", "inserting", + "two", "offer", + "crystal", "attractive", - "biologically", - "modular", - "generalized", + "conformation", + "however", + "computationally", + "experimentally", + "family", + "level", + "matches", + "nanotechnology", + "approach", + "showing", + "proteins", + "large", "constructed", - "precision", - "understood", - "extension", - "two", - "problem", + "use", + "modular", "scaffold", - "domains", - "synthesized", - "protein", - "backbone", - "projecting", - "hairpin", + "pentapeptide", + "construct", "computational", + "design", + "onto", + "atomic", + "length", "accommodate", - "folding", + "loops", + "incorrect", + "resolved", + "domain", + "also", + "projecting", + "chemically", + "shown", + "understood", + "backbone", + "ability", + "solved", + "insertions", "developed", + "designed", + "basic", + "one", "loop", - "level", - "resolved" + "variants", + "extension", + "structures", + "de", + "fragments", + "synthesized", + "based", + "hairpin", + "without", + "structure", + "synthetic", + "repetitive", + "closely", + "target", + "biologically", + "known", + "class", + "unit", + "problem", + "designs", + "better" ], "release_date":"2016-08-31", "publication":"\"Synthetic beta-solenoid proteins with the fragment-free computational design of a beta-hairpin extension\", Proc.Natl.Acad.Sci.USA, 113, 10346-10351", @@ -150409,27 +150783,27 @@ }, { "sim":57.0, - "partner":"4evc" + "partner":"3ta8" }, { "sim":57.0, - "partner":"4evd" + "partner":"3t9j" }, { "sim":57.0, - "partner":"4eve" + "partner":"4evb" }, { "sim":57.0, - "partner":"3ta8" + "partner":"4evc" }, { "sim":57.0, - "partner":"3t9j" + "partner":"4evd" }, { "sim":57.0, - "partner":"4evb" + "partner":"4eve" }, { "sim":57.0, @@ -150503,10 +150877,6 @@ "sim":55.0, "partner":"3nd1" }, - { - "sim":55.0, - "partner":"4d2w" - }, { "sim":55.0, "partner":"4d2p" @@ -150541,11 +150911,11 @@ }, { "sim":55.0, - "partner":"2rim" + "partner":"4d2w" }, { - "sim":54.0, - "partner":"3rg6" + "sim":55.0, + "partner":"2rim" }, { "sim":54.0, @@ -150559,6 +150929,10 @@ "sim":54.0, "partner":"2peo" }, + { + "sim":54.0, + "partner":"3rg6" + }, { "sim":54.0, "partner":"3ffl" @@ -150679,10 +151053,6 @@ "sim":53.0, "partner":"2ews" }, - { - "sim":53.0, - "partner":"4rtl" - }, { "sim":53.0, "partner":"4rtm" @@ -150725,7 +151095,7 @@ }, { "sim":53.0, - "partner":"3ws7" + "partner":"4rtl" }, { "sim":53.0, @@ -150737,11 +151107,7 @@ }, { "sim":53.0, - "partner":"4h2w" - }, - { - "sim":53.0, - "partner":"3mey" + "partner":"3ws7" }, { "sim":53.0, @@ -150779,6 +151145,14 @@ "sim":53.0, "partner":"4h2v" }, + { + "sim":53.0, + "partner":"4h2w" + }, + { + "sim":53.0, + "partner":"3mey" + }, { "sim":53.0, "partner":"4rq9" @@ -150851,10 +151225,6 @@ "sim":52.0, "partner":"4p6c" }, - { - "sim":52.0, - "partner":"4yvk" - }, { "sim":52.0, "partner":"4yqd" @@ -150879,6 +151249,10 @@ "sim":52.0, "partner":"4yvj" }, + { + "sim":52.0, + "partner":"4yvk" + }, { "sim":52.0, "partner":"1uaj" @@ -151011,10 +151385,6 @@ "sim":52.0, "partner":"4buc" }, - { - "sim":52.0, - "partner":"2q5l" - }, { "sim":52.0, "partner":"2q5o" @@ -151031,6 +151401,10 @@ "sim":52.0, "partner":"2q5j" }, + { + "sim":52.0, + "partner":"2q5l" + }, { "sim":52.0, "partner":"5d6r" @@ -151111,10 +151485,6 @@ "sim":51.0, "partner":"4lfn" }, - { - "sim":51.0, - "partner":"2vbq" - }, { "sim":51.0, "partner":"1s3z" @@ -151127,6 +151497,10 @@ "sim":51.0, "partner":"1s60" }, + { + "sim":51.0, + "partner":"2vbq" + }, { "sim":51.0, "partner":"2znz" @@ -151187,10 +151561,6 @@ "sim":51.0, "partner":"3ofv" }, - { - "sim":51.0, - "partner":"5bnq" - }, { "sim":51.0, "partner":"3me2" @@ -151201,12 +151571,16 @@ }, { "sim":51.0, - "partner":"3oci" + "partner":"5bnq" }, { "sim":51.0, "partner":"3oc3" }, + { + "sim":51.0, + "partner":"3oci" + }, { "sim":51.0, "partner":"1upi" @@ -151245,11 +151619,11 @@ }, { "sim":51.0, - "partner":"3rpu" + "partner":"8tlb" }, { "sim":51.0, - "partner":"8tlb" + "partner":"3rpu" }, { "sim":51.0, @@ -151257,15 +151631,15 @@ }, { "sim":51.0, - "partner":"4be6" + "partner":"4bei" }, { "sim":51.0, - "partner":"4bei" + "partner":"4be5" }, { "sim":51.0, - "partner":"4be5" + "partner":"4be6" }, { "sim":51.0, @@ -151295,6 +151669,22 @@ "sim":51.0, "partner":"8rwq" }, + { + "sim":51.0, + "partner":"8rwr" + }, + { + "sim":51.0, + "partner":"8rws" + }, + { + "sim":51.0, + "partner":"8rwo" + }, + { + "sim":51.0, + "partner":"8rwp" + }, { "sim":51.0, "partner":"3et1" @@ -151321,27 +151711,27 @@ }, { "sim":51.0, - "partner":"3g3d" + "partner":"3bvj" }, { "sim":51.0, - "partner":"5a7y" + "partner":"3mw7" }, { "sim":51.0, - "partner":"3bvj" + "partner":"4hib" }, { "sim":51.0, - "partner":"3mw7" + "partner":"4hkp" }, { "sim":51.0, - "partner":"4hib" + "partner":"3g3d" }, { "sim":51.0, - "partner":"4hkp" + "partner":"5a7y" }, { "sim":51.0, @@ -151385,39 +151775,39 @@ }, { "sim":51.0, - "partner":"3sie" + "partner":"4i9z" }, { "sim":51.0, - "partner":"4g2w" + "partner":"4ia0" }, { "sim":51.0, - "partner":"4g2y" + "partner":"4oew" }, { "sim":51.0, - "partner":"4i9z" + "partner":"4oex" }, { "sim":51.0, - "partner":"4ia0" + "partner":"3shy" }, { "sim":51.0, - "partner":"4oew" + "partner":"3shz" }, { "sim":51.0, - "partner":"4oex" + "partner":"3sie" }, { "sim":51.0, - "partner":"3shy" + "partner":"4g2w" }, { "sim":51.0, - "partner":"3shz" + "partner":"4g2y" }, { "sim":51.0, @@ -151447,10 +151837,6 @@ "sim":51.0, "partner":"3wxm" }, - { - "sim":51.0, - "partner":"3c1y" - }, { "sim":51.0, "partner":"3c1z" @@ -151475,6 +151861,10 @@ "sim":51.0, "partner":"4yxm" }, + { + "sim":51.0, + "partner":"3c1y" + }, { "sim":51.0, "partner":"2rjg" @@ -151523,10 +151913,6 @@ "sim":51.0, "partner":"3vvm" }, - { - "sim":51.0, - "partner":"2y6r" - }, { "sim":51.0, "partner":"4a99" @@ -151547,6 +151933,10 @@ "sim":51.0, "partner":"2y6q" }, + { + "sim":51.0, + "partner":"2y6r" + }, { "sim":51.0, "partner":"3k01" @@ -151599,10 +151989,6 @@ "sim":51.0, "partner":"4lf2" }, - { - "sim":51.0, - "partner":"4cdm" - }, { "sim":51.0, "partner":"4cdn" @@ -151615,6 +152001,10 @@ "sim":51.0, "partner":"2xrz" }, + { + "sim":51.0, + "partner":"4cdm" + }, { "sim":51.0, "partner":"3ug3" @@ -151643,10 +152033,6 @@ "sim":51.0, "partner":"3qfb" }, - { - "sim":51.0, - "partner":"2cj9" - }, { "sim":51.0, "partner":"2cja" @@ -151659,6 +152045,10 @@ "sim":51.0, "partner":"2cjb" }, + { + "sim":51.0, + "partner":"2cj9" + }, { "sim":51.0, "partner":"4s21" @@ -151709,11 +152099,11 @@ }, { "sim":50.0, - "partner":"3gz2" + "partner":"4oml" }, { "sim":50.0, - "partner":"4oml" + "partner":"3gz2" }, { "sim":50.0, @@ -151777,15 +152167,15 @@ }, { "sim":50.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":50.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":50.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":50.0, @@ -151813,15 +152203,15 @@ }, { "sim":50.0, - "partner":"3sw1" + "partner":"5j3w" }, { "sim":50.0, - "partner":"5j3w" + "partner":"5j4e" }, { "sim":50.0, - "partner":"5j4e" + "partner":"3sw1" }, { "sim":50.0, @@ -151841,11 +152231,11 @@ }, { "sim":50.0, - "partner":"2ela" + "partner":"2b6b" }, { "sim":50.0, - "partner":"2b6b" + "partner":"2ela" }, { "sim":50.0, @@ -151881,11 +152271,11 @@ }, { "sim":50.0, - "partner":"4kce" + "partner":"2h66" }, { "sim":50.0, - "partner":"2h66" + "partner":"4kce" }, { "sim":50.0, @@ -151901,11 +152291,11 @@ }, { "sim":50.0, - "partner":"4jr4" + "partner":"4jr6" }, { "sim":50.0, - "partner":"4jr6" + "partner":"4jr4" }, { "sim":50.0, @@ -151931,10 +152321,6 @@ "sim":50.0, "partner":"2fz4" }, - { - "sim":50.0, - "partner":"3la7" - }, { "sim":50.0, "partner":"3la2" @@ -151945,15 +152331,15 @@ }, { "sim":50.0, - "partner":"3r6s" + "partner":"3la7" }, { "sim":50.0, - "partner":"2rde" + "partner":"3r6s" }, { "sim":50.0, - "partner":"4da6" + "partner":"2rde" }, { "sim":50.0, @@ -152007,6 +152393,10 @@ "sim":50.0, "partner":"4d8v" }, + { + "sim":50.0, + "partner":"4da6" + }, { "sim":50.0, "partner":"2yfa" @@ -152021,15 +152411,15 @@ }, { "sim":50.0, - "partner":"1zw3" + "partner":"1zvz" }, { "sim":50.0, - "partner":"1zvz" + "partner":"1zw2" }, { "sim":50.0, - "partner":"1zw2" + "partner":"1zw3" }, { "sim":50.0, @@ -152043,10 +152433,6 @@ "sim":50.0, "partner":"2jfq" }, - { - "sim":50.0, - "partner":"4rdh" - }, { "sim":50.0, "partner":"4rdi" @@ -152071,6 +152457,10 @@ "sim":50.0, "partner":"5djj" }, + { + "sim":50.0, + "partner":"4rdh" + }, { "sim":50.0, "partner":"5djk" @@ -152089,11 +152479,11 @@ }, { "sim":50.0, - "partner":"3ta4" + "partner":"3t9w" }, { "sim":50.0, - "partner":"3t9w" + "partner":"3ta4" }, { "sim":50.0, @@ -152105,19 +152495,19 @@ }, { "sim":50.0, - "partner":"3nha" + "partner":"3nh6" }, { "sim":50.0, - "partner":"3nhb" + "partner":"3nh9" }, { "sim":50.0, - "partner":"3nh6" + "partner":"3nha" }, { "sim":50.0, - "partner":"3nh9" + "partner":"3nhb" }, { "sim":50.0, @@ -152125,31 +152515,31 @@ }, { "sim":50.0, - "partner":"3ggo" + "partner":"3ggp" }, { "sim":50.0, - "partner":"3ggp" + "partner":"3ggg" }, { "sim":50.0, - "partner":"3ggg" + "partner":"3ggo" }, { "sim":50.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":50.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":50.0, - "partner":"3tm8" + "partner":"3tmc" }, { "sim":50.0, - "partner":"3tmb" + "partner":"3tmd" }, { "sim":50.0, @@ -152161,15 +152551,15 @@ }, { "sim":50.0, - "partner":"2pzm" + "partner":"2pzk" }, { "sim":50.0, - "partner":"2pzk" + "partner":"2pzl" }, { "sim":50.0, - "partner":"2pzl" + "partner":"2pzm" }, { "sim":50.0, @@ -152287,10 +152677,6 @@ "sim":50.0, "partner":"3kzk" }, - { - "sim":50.0, - "partner":"4m1i" - }, { "sim":50.0, "partner":"4d8f" @@ -152303,6 +152689,10 @@ "sim":50.0, "partner":"4m1h" }, + { + "sim":50.0, + "partner":"4m1i" + }, { "sim":50.0, "partner":"2b61" @@ -152343,14 +152733,6 @@ "sim":50.0, "partner":"4ocv" }, - { - "sim":50.0, - "partner":"4q3r" - }, - { - "sim":50.0, - "partner":"4q42" - }, { "sim":50.0, "partner":"4q3s" @@ -152385,19 +152767,23 @@ }, { "sim":50.0, - "partner":"3o2t" + "partner":"4q3r" }, { "sim":50.0, - "partner":"3bu7" + "partner":"4q42" }, { "sim":50.0, - "partner":"2xyo" + "partner":"3o2t" }, { "sim":50.0, - "partner":"4hcl" + "partner":"3bu7" + }, + { + "sim":50.0, + "partner":"2xyo" }, { "sim":50.0, @@ -152411,6 +152797,10 @@ "sim":50.0, "partner":"3au7" }, + { + "sim":50.0, + "partner":"4hcl" + }, { "sim":50.0, "partner":"4r9v" @@ -152441,11 +152831,11 @@ }, { "sim":50.0, - "partner":"3wkr" + "partner":"3wks" }, { "sim":50.0, - "partner":"3wks" + "partner":"3wkr" }, { "sim":50.0, @@ -152453,15 +152843,15 @@ }, { "sim":50.0, - "partner":"4euh" + "partner":"4eue" }, { "sim":50.0, - "partner":"4eue" + "partner":"4euf" }, { "sim":50.0, - "partner":"4euf" + "partner":"4euh" }, { "sim":50.0, @@ -152487,17 +152877,13 @@ "sim":50.0, "partner":"2alm" }, - { - "sim":50.0, - "partner":"2yhg" - }, { "sim":50.0, "partner":"4doy" }, { "sim":50.0, - "partner":"3amu" + "partner":"2yhg" }, { "sim":50.0, @@ -152505,11 +152891,11 @@ }, { "sim":50.0, - "partner":"2yjn" + "partner":"3amu" }, { "sim":50.0, - "partner":"2r98" + "partner":"2yjn" }, { "sim":50.0, @@ -152531,6 +152917,10 @@ "sim":50.0, "partner":"4i49" }, + { + "sim":50.0, + "partner":"2r98" + }, { "sim":50.0, "partner":"3qfs" @@ -152595,10 +152985,6 @@ "sim":50.0, "partner":"4tmu" }, - { - "sim":50.0, - "partner":"2r0p" - }, { "sim":50.0, "partner":"2r0c" @@ -152621,12 +153007,16 @@ }, { "sim":50.0, - "partner":"5ess" + "partner":"2r0p" }, { "sim":50.0, "partner":"5esd" }, + { + "sim":50.0, + "partner":"5ess" + }, { "sim":50.0, "partner":"5esu" @@ -152655,17 +153045,13 @@ "sim":50.0, "partner":"3fjo" }, - { - "sim":50.0, - "partner":"4gyk" - }, { "sim":50.0, "partner":"4gyj" }, { "sim":50.0, - "partner":"2fw3" + "partner":"4gyk" }, { "sim":50.0, @@ -152687,6 +153073,10 @@ "sim":50.0, "partner":"4eph" }, + { + "sim":50.0, + "partner":"2fw3" + }, { "sim":50.0, "partner":"2bpo" @@ -152825,68 +153215,68 @@ ], "subtitle":"Crystal structure of de novo designed protein ca01", "tags":[ - "protein engineering", "computational design", - "de novo protein" + "de novo protein", + "protein engineering" ], "keywords":[ - "diverse", - "builds", - "cases", - "angstrom", - "called", - "excellent", - "magnetic", - "proteins", - "connected", + "tertiary", + "designed", "models", - "solved", - "respectively", - "large", - "remain", - "process", - "de", - "novo", - "strategy", + "angstrom", + "design", + "structural", "resolution", - "scaffolds", - "crystallography", - "rapidly", - "method", - "designed", - "preexisting", - "functions", - "da05r1", + "diverse", + "provides", + "structures", + "de", + "respectively", + "natural", "agreement", + "inspired", + "called", + "rapidly", + "scaffolds", "protocol", "ca01", - "nuclear", + "new", + "strategy", + "connected", + "functions", + "numbers", + "crystallography", + "designable", + "protein", + "magnetic", "folded", - "provides", - "absent", - "features", - "design", + "cases", + "proteins", "helical", - "structures", - "protein", - "natural", - "existing", - "describe", - "tertiary", + "large", + "process", + "absent", + "builds", + "novo", + "remain", "resonance", + "preexisting", "pieces", + "solved", + "excellent", + "contain", + "sewing", "combines", - "computational", + "disconnected", + "existing", + "nuclear", "recombination", - "numbers", - "designable", - "sewing", - "inspired", - "structural", + "describe", + "features", + "da05r1", "create", - "contain", - "disconnected", - "new" + "method", + "computational" ], "release_date":"2016-05-18", "publication":"\"Design of structurally distinct proteins using strategies inspired by evolution\", Science, 352, 687-690", @@ -153003,87 +153393,87 @@ ], "subtitle":"A de novo designed hexameric coiled-coil peptide with iodotyrosine", "tags":[ - "peptide design", "de novo protein", + "peptide design", "coiled-coil" ], "keywords":[ + "trimer", + "designed", + "introduction", "drastic", - "makes", - "coiled", - "demonstrate", + "pentamer", + "dimers", + "highlight", + "antiparallel", + "coupled", + "design", + "conformational", "many", - "results", - "change", - "forms", - "proteins", + "energy", + "pka", + "6", + "structural", + "candidate", "protonation", - "values", - "conformational", - "helices", - "hexamer", - "remarkable", "de", - "oligomerization", "single", - "stable", - "novo", - "trimer", - "changes", - "attractive", - "acid", - "peptide", - "6", - "candidate", - "designed", - "enable", - "switch", + "rationally", + "computationally", + "otherwise", "residues", - "highly", + "discovered", + "upshifted", + "acid", + "results", + "transition", + "insertion", + "protein", + "makes", "useful", - "landscape", - "difficult", - "pka", - "parallel", + "oligomerization", + "ph", + "destabilizing", + "proteins", "symmetric", - "antiparallel", - "dimers", + "changes", + "remarkable", + "formation", + "oligomer", + "enable", + "coiled", + "change", + "sensing", + "novo", "ability", - "destabilizing", + "demonstrate", "scaffold", - "design", - "sensing", - "highlight", - "narrow", - "protein", - "rationally", - "8", - "introduction", - "applications", - "switches", + "parallel", "states", - "insertion", - "coils", + "glutamatic", + "highly", + "sequence", + "difficult", + "landscape", + "forms", + "switch", "vast", + "applications", + "stable", + "coils", "describe", "caused", - "sequence", - "upshifted", - "computationally", - "energy", - "transition", - "formation", - "ph", - "oligomer", - "pentamer", - "coupled", - "otherwise", - "element", - "structural", + "range", "isoenergetic", - "discovered", - "glutamatic", - "range" + "8", + "attractive", + "element", + "helices", + "switches", + "peptide", + "values", + "hexamer", + "narrow" ], "release_date":"2016-06-15", "publication":"\"A De Novo Designed Coiled-Coil Peptide with a Reversible pH-Induced Oligomerization Switch\", Structure, 24, 946-955", @@ -153207,80 +153597,80 @@ ], "subtitle":"Computational design of a high-affinity metalloprotein homotrimer containing a metal chelating non-canonical amino acid", "tags":[ - "non canonical aminoacid", + "bpy", "de novo protein", "design", - "bpy" + "non canonical aminoacid" ], "keywords":[ - "accuracy", - "metalloprotein", - "monomers", "analysis", - "demonstrate", - "results", - "one", + "nanostructures", + "rmsd", + "design", + "energy", "specified", - "amino", - "proteins", - "use", - "assemblies", + "one", + "nucleate", + "used", "complexes", "homotrimer", - "process", - "wide", - "noncanonical", - "\u00e5", - "principle", - "acid", - "rosetta", - "acids", - "together", - "small", - "used", - "interface", + "metalloprotein", + "3", + "widespread", + "free", + "assembly", + "monomers", "residues", - "found", - "photophysical", - "alternatives", "specific", - "precisely", - "fe", - "nanostructures", - "3", - "crystal", - "blocks", + "rosetta", + "acid", + "structure", + "\u00e5", + "results", "homotrimeric", - "find", - "introduced", - "design", - "crystallographic", + "alanine", + "noncanonical", "model", + "precisely", "drive", "protein", + "amino", + "alternatives", + "wide", + "heteroaryl", + "blocks", + "proteins", + "process", "genetically", + "molecules", + "accuracy", + "formation", + "showed", + "use", + "together", + "find", + "much", + "demonstrate", + "building", + "interface", + "small", + "found", + "acids", + "principle", "applications", - "heteroaryl", + "photophysical", + "crystal", + "fe", "describe", - "structure", - "assembly", - "showed", - "nucleate", - "widespread", - "encoded", - "energy", - "could", + "range", + "assemblies", + "introduced", + "crystallographic", "computational", "methodology", - "formation", - "building", - "molecules", - "free", - "much", - "alanine", "lower", - "rmsd", - "range" + "encoded", + "could" ], "release_date":"2016-11-16", "publication":"\"Computational design of a homotrimeric metalloprotein with a trisbipyridyl core\", Proc. Natl. Acad. Sci. U.S.A., 113, 15012-15017", @@ -153465,11 +153855,11 @@ }, { "sim":160.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":160.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":160.0, @@ -153489,11 +153879,11 @@ }, { "sim":160.0, - "partner":"8a1a" + "partner":"8a19" }, { "sim":160.0, - "partner":"8a19" + "partner":"8a1a" }, { "sim":159.0, @@ -153529,19 +153919,19 @@ }, { "sim":157.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":157.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":157.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":157.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":157.0, @@ -153549,35 +153939,35 @@ }, { "sim":157.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":157.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":157.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":157.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":157.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":157.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":157.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":157.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":157.0, @@ -153585,7 +153975,7 @@ }, { "sim":157.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":157.0, @@ -153593,7 +153983,7 @@ }, { "sim":157.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":156.0, @@ -153645,20 +154035,24 @@ }, { "sim":124.0, - "partner":"8rci" + "partner":"7z73" }, { "sim":124.0, - "partner":"7z73" + "partner":"8rci" }, { "sim":122.0, - "partner":"7b4v" + "partner":"9glq" }, { "sim":122.0, "partner":"7b4u" }, + { + "sim":122.0, + "partner":"7b4v" + }, { "sim":117.0, "partner":"9f24" @@ -153733,10 +154127,6 @@ "sim":163.0, "partner":"4jb8" }, - { - "sim":162.0, - "partner":"5eno" - }, { "sim":162.0, "partner":"4dx6" @@ -153801,6 +154191,10 @@ "sim":162.0, "partner":"4dx5" }, + { + "sim":162.0, + "partner":"5eno" + }, { "sim":160.0, "partner":"4f6r" @@ -153871,11 +154265,11 @@ }, { "sim":149.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":149.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":149.0, @@ -153919,15 +154313,15 @@ }, { "sim":122.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":122.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":122.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":121.0, @@ -154059,11 +154453,11 @@ }, { "sim":99.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":99.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":98.0, @@ -154187,11 +154581,11 @@ }, { "sim":85.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":85.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":85.0, @@ -154291,15 +154685,15 @@ }, { "sim":70.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":70.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":70.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":70.0, @@ -154353,10 +154747,6 @@ "sim":69.0, "partner":"4bet" }, - { - "sim":66.0, - "partner":"5iwr" - }, { "sim":66.0, "partner":"5iwt" @@ -154369,6 +154759,10 @@ "sim":66.0, "partner":"5iwp" }, + { + "sim":66.0, + "partner":"5iwr" + }, { "sim":65.0, "partner":"8pef" @@ -154518,93 +154912,93 @@ ], "subtitle":"Crystal structure of an antiparallel hexamer coiled-coil - acc-hex-phei", "tags":[ - "hexamer", - "heptad repeat", "de novo protein", - "coiled-coil" + "hexamer", + "coiled-coil", + "heptad repeat" ], "keywords":[ - "containing", - "oligomers", - "studies", - "scattering", - "suggest", - "scaffolds", - "acid", - "peptide", - "temperatures", - "hexamers", + "relatively", + "dimers", + "hydrophobic", "show", - "based", - "software", - "synthetic", + "around", + "acid", + "new", + "protein", + "six", + "comprising", + "motif", "equilibrium", - "chromatography", + "novo", + "circular", + "motifs", + "stable", + "aggregates", + "temperatures", + "encoded", + "material", "associating", - "represent", - "structure", + "supramolecular", + "toolbox", + "antiparallel", + "shows", + "residues", + "neither", + "hexamers", "axis", - "principles", - "aromatic", - "interaction", "proteins", + "scattering", + "suggest", "larger", - "biomolecular", - "presented", - "de", - "\u00e5", - "expands", - "motif", - "nature", - "dynamics", - "structures", - "material", - "solution", - "assembly", - "circular", - "neither", - "motifs", - "form", - "shows", - "previously", - "toolbox", - "amino", - "among", + "found", "1", + "peptide", "behavior", - "six", - "observed", - "crystallographic", "design", - "present", - "hydrophobic", - "existing", - "high", - "sequence", - "encoded", - "indicate", - "around", - "aggregates", + "principles", + "expands", + "represent", + "1a", + "assembly", + "experiments", + "biomolecular", + "amino", + "chromatography", + "solution", + "interaction", "predicted", - "supramolecular", + "sequence", "arrangement", - "novo", - "stable", - "experiments", "peptides", - "1a", - "residues", - "found", - "dimers", - "antiparallel", - "central", - "protein", - "relatively", "relationship", + "present", + "crystallographic", + "dynamics", + "form", + "central", + "aromatic", + "indicate", + "observed", + "structures", + "de", + "oligomers", + "previously", + "based", + "\u00e5", + "structure", + "synthetic", + "among", + "scaffolds", + "nature", "understanding", - "comprising", + "software", + "presented", + "high", "dichroism", - "new" + "studies", + "existing", + "containing" ], "release_date":"2016-05-25", "publication":"\"X-ray Crystallographic Structure and Solution Behavior of an Antiparallel Coiled-Coil Hexamer Formed by de Novo Peptides\", Biochemistry, 55, 3214-3223", @@ -154661,29 +155055,25 @@ "sim":0.9865000248, "partner":"6q5n" }, - { - "sim":0.9940000176, - "partner":"4h8m" - }, { "sim":0.9916999936, "partner":"6q5p" }, { - "sim":0.9968000054, - "partner":"3r48" + "sim":0.9940000176, + "partner":"4h8m" }, { "sim":0.9948999882, "partner":"3r46" }, { - "sim":0.9937999845, - "partner":"6q5o" + "sim":0.9968000054, + "partner":"3r48" }, { - "sim":0.997600019, - "partner":"4h7r" + "sim":0.9937999845, + "partner":"6q5o" }, { "sim":0.9708999991, @@ -154693,22 +155083,30 @@ "sim":0.9957000017, "partner":"6q5j" }, + { + "sim":0.997600019, + "partner":"4h7r" + }, { "sim":0.9965999722, "partner":"6q5s" }, { - "sim":1.0, - "partner":"4h8o" + "sim":0.9508000016, + "partner":"3r47" }, { - "sim":0.9973999858, - "partner":"8qac" + "sim":1.0, + "partner":"4h8o" }, { "sim":0.9617999792, "partner":"8a3g" }, + { + "sim":0.9973999858, + "partner":"8qac" + }, { "sim":0.9689000249, "partner":"6q5r" @@ -154733,14 +155131,14 @@ "sim":0.9918000102, "partner":"4dzl" }, - { - "sim":0.9761999846, - "partner":"8qab" - }, { "sim":0.992200017, "partner":"1cos" }, + { + "sim":0.9761999846, + "partner":"8qab" + }, { "sim":0.9901999831, "partner":"2jgo" @@ -154764,10 +155162,6 @@ { "sim":0.9934999943, "partner":"5u9u" - }, - { - "sim":0.9508000016, - "partner":"3r47" } ], "struct_thr_sim_natural":[ @@ -154834,93 +155228,93 @@ ], "subtitle":"Crystal structure of a de novo antiparallel coiled-coil hexamer - acc-hex", "tags":[ - "hexamer", + "antiparallel", "de novo protein", - "coiled-coil", - "antiparallel" + "hexamer", + "coiled-coil" ], "keywords":[ - "containing", - "oligomers", - "studies", - "scattering", - "suggest", - "scaffolds", - "acid", - "peptide", - "temperatures", - "hexamers", + "relatively", + "dimers", + "hydrophobic", "show", - "based", - "software", - "synthetic", + "around", + "acid", + "new", + "protein", + "six", + "comprising", + "motif", "equilibrium", - "chromatography", + "novo", + "circular", + "motifs", + "stable", + "aggregates", + "temperatures", + "encoded", + "material", "associating", - "represent", - "structure", + "supramolecular", + "toolbox", + "antiparallel", + "shows", + "residues", + "neither", + "hexamers", "axis", - "principles", - "aromatic", - "interaction", "proteins", + "scattering", + "suggest", "larger", - "biomolecular", - "presented", - "de", - "\u00e5", - "expands", - "motif", - "nature", - "dynamics", - "structures", - "material", - "solution", - "assembly", - "circular", - "neither", - "motifs", - "form", - "shows", - "previously", - "toolbox", - "amino", - "among", + "found", "1", + "peptide", "behavior", - "six", - "observed", - "crystallographic", "design", - "present", - "hydrophobic", - "existing", - "high", - "sequence", - "encoded", - "indicate", - "around", - "aggregates", + "principles", + "expands", + "represent", + "1a", + "assembly", + "experiments", + "biomolecular", + "amino", + "chromatography", + "solution", + "interaction", "predicted", - "supramolecular", + "sequence", "arrangement", - "novo", - "stable", - "experiments", "peptides", - "1a", - "residues", - "found", - "dimers", - "antiparallel", - "central", - "protein", - "relatively", "relationship", + "present", + "crystallographic", + "dynamics", + "form", + "central", + "aromatic", + "indicate", + "observed", + "structures", + "de", + "oligomers", + "previously", + "based", + "\u00e5", + "structure", + "synthetic", + "among", + "scaffolds", + "nature", "understanding", - "comprising", + "software", + "presented", + "high", "dichroism", - "new" + "studies", + "existing", + "containing" ], "release_date":"2016-05-25", "publication":"\"X-ray Crystallographic Structure and Solution Behavior of an Antiparallel Coiled-Coil Hexamer Formed by de Novo Peptides\", Biochemistry, 55, 3214-3223", @@ -154975,11 +155369,11 @@ }, { "sim":1.0, - "partner":"4h8m" + "partner":"6q5p" }, { "sim":1.0, - "partner":"6q5p" + "partner":"4h8m" }, { "sim":1.0, @@ -155013,14 +155407,14 @@ "sim":0.9549000263, "partner":"3r47" }, - { - "sim":0.9715999961, - "partner":"8a3g" - }, { "sim":1.0, "partner":"8qac" }, + { + "sim":0.9715999961, + "partner":"8a3g" + }, { "sim":0.9767000079, "partner":"6q5r" @@ -155029,14 +155423,14 @@ "sim":0.9761999846, "partner":"4h8f" }, - { - "sim":0.9761999846, - "partner":"6q5q" - }, { "sim":1.0, "partner":"4h8o" }, + { + "sim":0.9761999846, + "partner":"6q5q" + }, { "sim":0.9767000079, "partner":"8qaa" @@ -155061,18 +155455,14 @@ "sim":0.9883999825, "partner":"1cos" }, - { - "sim":0.9896000028, - "partner":"2x6p" - }, - { - "sim":0.9958999753, - "partner":"3r4h" - }, { "sim":1.0, "partner":"2jgo" }, + { + "sim":0.9896000028, + "partner":"2x6p" + }, { "sim":1.0, "partner":"3ljm" @@ -155089,6 +155479,10 @@ "sim":0.997699976, "partner":"5u9u" }, + { + "sim":0.9958999753, + "partner":"3r4h" + }, { "sim":1.0, "partner":"4dzl" @@ -155116,11 +155510,11 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"4h8m" + "partner":"6q5p" }, "struct_max_sim_natural":{ "sim":1.0, - "partner":"4kvt" + "partner":"4kvu" }, "review_comment":[ "" @@ -155195,92 +155589,92 @@ ], "subtitle":"Crystal structure of de novo designed fullerene organizing peptide", "tags":[ - "complex", + "helical assembly", "de novo protein", - "fullerene", - "helical assembly" + "complex", + "fullerene" ], "keywords":[ - "insulating", - "geometrically", - "periodic", - "ordered", - "fullerene", - "suggest", - "lattice", - "organizing", - "crystal", - "findings", - "precise", - "structure", - "rich", "affinity", - "associate", - "direct", - "tailored", - "proteins", - "rendering", - "tetramers", - "organization", - "binds", - "motif", - "nanomolar", - "solution", - "tyr", - "assembly", - "revealed", - "molecules", - "strikingly", - "previously", - "properties", - "taken", - "promoting", + "buckminsterfullerene", + "learning", + "matter", + "new", "exhibits", "superstructures", - "generate", - "occupy", - "c60", "amorphous", - "would", - "engineer", - "matter", - "compatible", - "bundle", - "lattices", - "design", + "strikingly", + "protein", "helical", - "soluble", - "high", - "known", - "learning", + "motif", + "together", "tetrameric", - "range", - "sites", - "buckminsterfullerene", + "promoting", + "site", "demonstrate", - "one", - "conductance", + "two", + "variety", + "precise", + "crystal", + "binds", + "adjacent", + "water", + "occupy", + "engineered", + "taken", + "organization", + "periodic", + "soluble", + "residues", + "charge", + "tyr", + "proteins", + "sites", + "tetramers", + "suggest", + "lattices", + "nanomolar", + "bundle", + "direct", + "design", + "insulating", + "associate", + "assembly", + "properties", + "rich", "groups", - "estimated", - "sandwiched", + "solution", + "incorporating", + "fullerene", + "crystals", + "organizing", + "geometrically", + "whereas", + "range", + "engineer", + "conductance", + "revealed", "electrically", + "one", + "tailored", + "previously", + "structure", + "findings", + "c60", "means", - "together", + "known", + "compatible", + "would", + "molecules", "enable", - "charge", - "engineered", - "residues", - "adjacent", - "two", - "incorporating", - "protein", - "variety", - "water", - "site", + "lattice", + "sandwiched", + "rendering", + "high", + "estimated", "create", - "crystals", - "new", - "whereas" + "ordered", + "generate" ], "release_date":"2016-05-04", "publication":"\"Protein-directed self-assembly of a fullerene crystal\", Nat Commun, 7, 11429-11429", @@ -155411,80 +155805,80 @@ "de novo assembly" ], "keywords":[ - "variant", - "framework", - "seven", - "facile", - "allows", - "acetate", - "tests", - "chains", - "improve", - "incorporation", - "functional", - "proteins", - "accepts", "construction", - "helices", - "accessible", + "accepts", + "flexibility", + "improve", + "triad", + "hydrolytic", + "engineered", + "design", "redesigned", - "truly", - "chemical", - "also", - "report", + "probe", + "show", + "mutations", + "thermostable", + "predictable", "de", - "novo", - "catalysts", - "unnatural", - "catalytic", - "barrel", - "hydrolyses", - "biochemical", - "scaffolds", - "acid", - "biocatalysts", - "channel", - "efficiencies", - "engineered", - "resulting", + "lumen", + "functional", + "natural", + "around", + "first", + "21", + "side", + "based", + "accessible", + "comprises", "residues", - "robust", - "mutations", - "flexibility", "synthesis", - "activity", - "triads", - "hydrolytic", - "comprises", - "system", - "hydrolases", + "acid", + "helix", + "variant", + "scaffolds", "polar", - "match", - "show", + "resulting", + "report", + "framework", + "also", + "efficiencies", + "protein", "relationships", - "design", + "hydrolases", + "understanding", + "completely", + "biochemical", + "proteins", "install", + "biocatalysts", + "allows", + "unnatural", "arranged", - "lumen", - "based", - "mechanism", - "protein", - "21", - "probe", + "holds", + "novo", + "activity", + "system", + "tests", + "seven", + "match", + "hydrolyses", + "catalytic", "promise", + "channel", + "triads", + "acetate", "applications", - "predictable", - "natural", - "helix", - "holds", - "understanding", - "completely", - "side", - "first", - "around", - "thermostable", + "chemical", "predictably", - "triad" + "helices", + "incorporation", + "chains", + "barrel", + "mechanism", + "truly", + "robust", + "catalysts", + "facile" ], "release_date":"2016-07-06", "publication":"\"Installing hydrolytic activity into a completely de novo protein framework\", Nat.Chem., 8, 837-844", @@ -155555,23 +155949,23 @@ }, { "sim":1.0, - "partner":"5ez9" + "partner":"4pn9" }, { "sim":1.0, - "partner":"8a09" + "partner":"5ez9" }, { - "sim":1.0, - "partner":"4pn9" + "sim":0.9973000288, + "partner":"6eiz" }, { "sim":1.0, - "partner":"5eza" + "partner":"8a09" }, { - "sim":0.9973000288, - "partner":"6eiz" + "sim":1.0, + "partner":"5eza" }, { "sim":1.0, @@ -155599,11 +155993,11 @@ }, { "sim":1.0, - "partner":"7nfg" + "partner":"6zt1" }, { "sim":1.0, - "partner":"6zt1" + "partner":"7nfg" }, { "sim":1.0, @@ -155625,10 +156019,6 @@ "sim":1.0, "partner":"7bav" }, - { - "sim":0.9958000183, - "partner":"8b15" - }, { "sim":1.0, "partner":"6g6f" @@ -155637,6 +156027,10 @@ "sim":1.0, "partner":"7nfh" }, + { + "sim":0.9761999846, + "partner":"6yaz" + }, { "sim":1.0, "partner":"6xy0" @@ -155649,6 +156043,10 @@ "sim":0.9769999981, "partner":"6yb0" }, + { + "sim":1.0, + "partner":"6g6c" + }, { "sim":1.0, "partner":"6xxz" @@ -155663,16 +156061,12 @@ }, { "sim":1.0, - "partner":"6g6c" + "partner":"7baw" }, { "sim":0.9941999912, "partner":"6g6b" }, - { - "sim":1.0, - "partner":"7baw" - }, { "sim":0.9983000159, "partner":"6g6a" @@ -155698,8 +156092,8 @@ "partner":"7bau" }, { - "sim":0.9761999846, - "partner":"6yaz" + "sim":0.9958000183, + "partner":"8b15" }, { "sim":0.9607999921, @@ -155709,6 +156103,10 @@ "sim":0.9887999892, "partner":"7bo9" }, + { + "sim":0.9686999917, + "partner":"9gf2" + }, { "sim":0.9984999895, "partner":"6g69" @@ -155794,84 +156192,84 @@ "tags":[ "de novo protein", "coiled coil", - "heptamer", - "de novo design" + "de novo design", + "heptamer" ], "keywords":[ - "variant", - "framework", - "seven", - "facile", - "allows", - "acetate", - "tests", - "chains", - "improve", - "incorporation", - "functional", - "proteins", - "accepts", "construction", - "helices", - "accessible", + "accepts", + "flexibility", + "improve", + "triad", + "hydrolytic", + "engineered", + "design", "redesigned", - "truly", - "chemical", - "also", - "report", + "probe", + "show", + "mutations", + "thermostable", + "predictable", "de", - "novo", - "catalysts", - "unnatural", - "catalytic", - "barrel", - "hydrolyses", - "biochemical", - "scaffolds", - "acid", - "biocatalysts", - "channel", - "efficiencies", - "engineered", - "resulting", + "lumen", + "functional", + "natural", + "around", + "first", + "21", + "side", + "based", + "accessible", + "comprises", "residues", - "robust", - "mutations", - "flexibility", "synthesis", - "activity", - "triads", - "hydrolytic", - "comprises", - "system", - "hydrolases", + "acid", + "helix", + "variant", + "scaffolds", "polar", - "match", - "show", + "resulting", + "report", + "framework", + "also", + "efficiencies", + "protein", "relationships", - "design", + "hydrolases", + "understanding", + "completely", + "biochemical", + "proteins", "install", + "biocatalysts", + "allows", + "unnatural", "arranged", - "lumen", - "based", - "mechanism", - "protein", - "21", - "probe", + "holds", + "novo", + "activity", + "system", + "tests", + "seven", + "match", + "hydrolyses", + "catalytic", "promise", + "channel", + "triads", + "acetate", "applications", - "predictable", - "natural", - "helix", - "holds", - "understanding", - "completely", - "side", - "first", - "around", - "thermostable", + "chemical", "predictably", - "triad" + "helices", + "incorporation", + "chains", + "barrel", + "mechanism", + "truly", + "robust", + "catalysts", + "facile" ], "release_date":"2016-07-06", "publication":"\"Installing hydrolytic activity into a completely de novo protein framework\", Nat.Chem., 8, 837-844", @@ -155908,6 +156306,10 @@ ], "struct_thr_sim_designed":[ + { + "sim":1.0, + "partner":"5eza" + }, { "sim":1.0, "partner":"5ezc" @@ -155921,12 +156323,12 @@ "partner":"6eik" }, { - "sim":0.9600999951, - "partner":"5eze" + "sim":1.0, + "partner":"7nfp" }, { "sim":1.0, - "partner":"5eza" + "partner":"7nfm" }, { "sim":1.0, @@ -155942,11 +156344,11 @@ }, { "sim":1.0, - "partner":"7nfk" + "partner":"8a09" }, { "sim":1.0, - "partner":"8a09" + "partner":"6xy1" }, { "sim":1.0, @@ -155954,23 +156356,27 @@ }, { "sim":1.0, - "partner":"7nfj" + "partner":"6eiz" }, { "sim":1.0, - "partner":"6eiz" + "partner":"6yb2" }, { "sim":1.0, - "partner":"6zt1" + "partner":"7nfk" + }, + { + "sim":0.9955999851, + "partner":"7nff" }, { "sim":1.0, - "partner":"7a1t" + "partner":"7nfi" }, { "sim":1.0, - "partner":"7bas" + "partner":"7nfj" }, { "sim":1.0, @@ -155981,8 +156387,8 @@ "partner":"7nfo" }, { - "sim":0.9973000288, - "partner":"8b15" + "sim":1.0, + "partner":"6xxz" }, { "sim":1.0, @@ -155990,75 +156396,71 @@ }, { "sim":1.0, - "partner":"7nfp" + "partner":"6g6g" }, { - "sim":1.0, - "partner":"6xy1" + "sim":0.9980999827, + "partner":"7nfg" }, { "sim":1.0, - "partner":"6g6f" + "partner":"6zt1" }, { "sim":1.0, - "partner":"7bav" + "partner":"7a1t" }, { "sim":1.0, - "partner":"7nfh" + "partner":"7bav" }, { "sim":1.0, - "partner":"7nfm" - }, - { - "sim":0.9957000017, - "partner":"6g6b" + "partner":"7bas" }, { "sim":1.0, - "partner":"7baw" + "partner":"7nfh" }, { - "sim":0.992299974, - "partner":"6g6a" + "sim":0.9973000288, + "partner":"8b15" }, { - "sim":1.0, - "partner":"7bat" + "sim":0.976000011, + "partner":"6yb0" }, { "sim":1.0, - "partner":"6g6g" + "partner":"6g6f" }, { - "sim":1.0, - "partner":"6yb2" + "sim":0.9970999956, + "partner":"4pn8" }, { - "sim":0.976000011, - "partner":"6yb0" + "sim":0.9991000295, + "partner":"6g6c" }, { - "sim":0.9955999851, - "partner":"7nff" + "sim":0.9957000017, + "partner":"6g6b" }, { - "sim":1.0, - "partner":"7nfi" + "sim":0.9980999827, + "partner":"6g65" }, { - "sim":0.9750999808, - "partner":"6yaz" + "sim":1.0, + "partner":"6g67" }, { "sim":1.0, - "partner":"7bau" + "partner":"7baw" }, { - "sim":0.9980999827, - "partner":"7nfg" + "sim":0.992299974, + "partner":"6g6a" }, { "sim":0.9986000061, @@ -156066,39 +156468,35 @@ }, { "sim":1.0, - "partner":"6xxz" - }, - { - "sim":0.9991000295, - "partner":"6g6c" + "partner":"7bat" }, { - "sim":0.9929000139, - "partner":"7bo9" + "sim":1.0, + "partner":"6g66" }, { "sim":1.0, - "partner":"6g67" + "partner":"7boa" }, { - "sim":0.9980999827, - "partner":"6g65" + "sim":1.0, + "partner":"4dzn" }, { - "sim":0.9970999956, - "partner":"4pn8" + "sim":0.9600999951, + "partner":"5eze" }, { - "sim":1.0, - "partner":"7boa" + "sim":0.9750999808, + "partner":"6yaz" }, { "sim":1.0, - "partner":"6g66" + "partner":"7bau" }, { - "sim":1.0, - "partner":"4dzn" + "sim":0.9929000139, + "partner":"7bo9" } ], "struct_thr_sim_natural":[ @@ -156112,7 +156510,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"5ezc" + "partner":"5eza" }, "struct_max_sim_natural":[ @@ -156172,80 +156570,80 @@ "heptamer" ], "keywords":[ - "variant", - "framework", - "seven", - "facile", - "allows", - "acetate", - "tests", - "chains", - "improve", - "incorporation", - "functional", - "proteins", - "accepts", "construction", - "helices", - "accessible", + "accepts", + "flexibility", + "improve", + "triad", + "hydrolytic", + "engineered", + "design", "redesigned", - "truly", - "chemical", - "also", - "report", + "probe", + "show", + "mutations", + "thermostable", + "predictable", "de", - "novo", - "catalysts", - "unnatural", - "catalytic", - "barrel", - "hydrolyses", - "biochemical", - "scaffolds", - "acid", - "biocatalysts", - "channel", - "efficiencies", - "engineered", - "resulting", + "lumen", + "functional", + "natural", + "around", + "first", + "21", + "side", + "based", + "accessible", + "comprises", "residues", - "robust", - "mutations", - "flexibility", "synthesis", - "activity", - "triads", - "hydrolytic", - "comprises", - "system", - "hydrolases", + "acid", + "helix", + "variant", + "scaffolds", "polar", - "match", - "show", + "resulting", + "report", + "framework", + "also", + "efficiencies", + "protein", "relationships", - "design", + "hydrolases", + "understanding", + "completely", + "biochemical", + "proteins", "install", + "biocatalysts", + "allows", + "unnatural", "arranged", - "lumen", - "based", - "mechanism", - "protein", - "21", - "probe", + "holds", + "novo", + "activity", + "system", + "tests", + "seven", + "match", + "hydrolyses", + "catalytic", "promise", + "channel", + "triads", + "acetate", "applications", - "predictable", - "natural", - "helix", - "holds", - "understanding", - "completely", - "side", - "first", - "around", - "thermostable", + "chemical", "predictably", - "triad" + "helices", + "incorporation", + "chains", + "barrel", + "mechanism", + "truly", + "robust", + "catalysts", + "facile" ], "release_date":"2016-07-06", "publication":"\"Installing hydrolytic activity into a completely de novo protein framework\", Nat.Chem., 8, 837-844", @@ -156372,11 +156770,11 @@ }, { "sim":1.0, - "partner":"6xxz" + "partner":"6zt1" }, { "sim":1.0, - "partner":"6zt1" + "partner":"6xxz" }, { "sim":1.0, @@ -156418,6 +156816,10 @@ "sim":0.9933000207, "partner":"6g6b" }, + { + "sim":0.9577000141, + "partner":"6yaz" + }, { "sim":1.0, "partner":"7baw" @@ -156453,10 +156855,6 @@ { "sim":1.0, "partner":"7boa" - }, - { - "sim":0.9577000141, - "partner":"6yaz" } ], "struct_thr_sim_natural":[ @@ -156530,80 +156928,80 @@ "heptamer" ], "keywords":[ - "variant", - "framework", - "seven", - "facile", - "allows", - "acetate", - "tests", - "chains", - "improve", - "incorporation", - "functional", - "proteins", - "accepts", "construction", - "helices", - "accessible", + "accepts", + "flexibility", + "improve", + "triad", + "hydrolytic", + "engineered", + "design", "redesigned", - "truly", - "chemical", - "also", - "report", + "probe", + "show", + "mutations", + "thermostable", + "predictable", "de", - "novo", - "catalysts", - "unnatural", - "catalytic", - "barrel", - "hydrolyses", - "biochemical", - "scaffolds", - "acid", - "biocatalysts", - "channel", - "efficiencies", - "engineered", - "resulting", + "lumen", + "functional", + "natural", + "around", + "first", + "21", + "side", + "based", + "accessible", + "comprises", "residues", - "robust", - "mutations", - "flexibility", "synthesis", - "activity", - "triads", - "hydrolytic", - "comprises", - "system", - "hydrolases", + "acid", + "helix", + "variant", + "scaffolds", "polar", - "match", - "show", + "resulting", + "report", + "framework", + "also", + "efficiencies", + "protein", "relationships", - "design", + "hydrolases", + "understanding", + "completely", + "biochemical", + "proteins", "install", + "biocatalysts", + "allows", + "unnatural", "arranged", - "lumen", - "based", - "mechanism", - "protein", - "21", - "probe", + "holds", + "novo", + "activity", + "system", + "tests", + "seven", + "match", + "hydrolyses", + "catalytic", "promise", + "channel", + "triads", + "acetate", "applications", - "predictable", - "natural", - "helix", - "holds", - "understanding", - "completely", - "side", - "first", - "around", - "thermostable", + "chemical", "predictably", - "triad" + "helices", + "incorporation", + "chains", + "barrel", + "mechanism", + "truly", + "robust", + "catalysts", + "facile" ], "release_date":"2016-07-06", "publication":"\"Installing hydrolytic activity into a completely de novo protein framework\", Nat.Chem., 8, 837-844", @@ -156646,11 +157044,11 @@ }, { "sim":1.0, - "partner":"5ez9" + "partner":"7nfn" }, { "sim":1.0, - "partner":"7nfn" + "partner":"5ez9" }, { "sim":1.0, @@ -156764,10 +157162,6 @@ "sim":0.9972000122, "partner":"6g6b" }, - { - "sim":0.9958000183, - "partner":"8b15" - }, { "sim":1.0, "partner":"7nfh" @@ -156816,6 +157210,10 @@ "sim":0.9607999921, "partner":"5eze" }, + { + "sim":0.9958000183, + "partner":"8b15" + }, { "sim":0.9970999956, "partner":"7bau" @@ -156895,86 +157293,86 @@ ], "subtitle":"A de novo designed heptameric coiled coil cc-hept-i18betamecys-l22h-i25e", "tags":[ - "de novo structure", "de novo protein", "coiled coil", - "heptamer" + "heptamer", + "de novo structure" ], "keywords":[ - "variant", - "framework", - "seven", - "facile", - "allows", - "acetate", - "tests", - "chains", - "improve", - "incorporation", - "functional", - "proteins", - "accepts", "construction", - "helices", - "accessible", + "accepts", + "flexibility", + "improve", + "triad", + "hydrolytic", + "engineered", + "design", "redesigned", - "truly", - "chemical", - "also", - "report", + "probe", + "show", + "mutations", + "thermostable", + "predictable", "de", - "novo", - "catalysts", - "unnatural", - "catalytic", - "barrel", - "hydrolyses", - "biochemical", - "scaffolds", - "acid", - "biocatalysts", - "channel", - "efficiencies", - "engineered", - "resulting", + "lumen", + "functional", + "natural", + "around", + "first", + "21", + "side", + "based", + "accessible", + "comprises", "residues", - "robust", - "mutations", - "flexibility", "synthesis", - "activity", - "triads", - "hydrolytic", - "comprises", - "system", - "hydrolases", + "acid", + "helix", + "variant", + "scaffolds", "polar", - "match", - "show", + "resulting", + "report", + "framework", + "also", + "efficiencies", + "protein", "relationships", - "design", + "hydrolases", + "understanding", + "completely", + "biochemical", + "proteins", "install", + "biocatalysts", + "allows", + "unnatural", "arranged", - "lumen", - "based", - "mechanism", - "protein", - "21", - "probe", + "holds", + "novo", + "activity", + "system", + "tests", + "seven", + "match", + "hydrolyses", + "catalytic", "promise", + "channel", + "triads", + "acetate", "applications", - "predictable", - "natural", - "helix", - "holds", - "understanding", - "completely", - "side", - "first", - "around", - "thermostable", + "chemical", "predictably", - "triad" + "helices", + "incorporation", + "chains", + "barrel", + "mechanism", + "truly", + "robust", + "catalysts", + "facile" ], "release_date":"2016-07-06", "publication":"\"Installing hydrolytic activity into a completely de novo protein framework\", Nat.Chem., 8, 837-844", @@ -157019,29 +157417,25 @@ "sim":1.0, "partner":"5ezc" }, - { - "sim":1.0, - "partner":"7nfn" - }, { "sim":1.0, "partner":"5ez9" }, { "sim":1.0, - "partner":"6eik" + "partner":"5eza" }, { "sim":1.0, - "partner":"5eza" + "partner":"7nfn" }, { "sim":1.0, - "partner":"7nfk" + "partner":"6eik" }, { "sim":1.0, - "partner":"6eiz" + "partner":"7nfp" }, { "sim":1.0, @@ -157049,11 +157443,11 @@ }, { "sim":1.0, - "partner":"7nfo" + "partner":"4pna" }, { "sim":1.0, - "partner":"4pna" + "partner":"7bim" }, { "sim":0.9984999895, @@ -157061,19 +157455,19 @@ }, { "sim":1.0, - "partner":"7nfl" + "partner":"7nfk" }, { "sim":1.0, - "partner":"7bim" + "partner":"7nfl" }, { "sim":1.0, - "partner":"8b16" + "partner":"7nfm" }, { - "sim":0.9883000255, - "partner":"8b15" + "sim":1.0, + "partner":"7nfo" }, { "sim":1.0, @@ -157081,43 +157475,43 @@ }, { "sim":1.0, - "partner":"7nfp" + "partner":"6eiz" }, { "sim":1.0, - "partner":"7bat" + "partner":"8b16" }, { - "sim":0.9940999746, - "partner":"6g6b" + "sim":1.0, + "partner":"7nff" }, { "sim":1.0, - "partner":"6g6f" + "partner":"8a09" }, { - "sim":1.0, - "partner":"6zt1" + "sim":0.9883000255, + "partner":"8b15" }, { "sim":0.9984999895, "partner":"7nfh" }, { - "sim":1.0, - "partner":"7nfm" + "sim":0.9940999746, + "partner":"6g6b" }, { - "sim":1.0, - "partner":"8a09" + "sim":0.9965999722, + "partner":"6g6g" }, { "sim":1.0, - "partner":"7nff" + "partner":"6g6f" }, { - "sim":0.9968000054, - "partner":"6g6a" + "sim":1.0, + "partner":"6zt1" }, { "sim":1.0, @@ -157129,7 +157523,11 @@ }, { "sim":1.0, - "partner":"7baw" + "partner":"7nfi" + }, + { + "sim":0.9650999904, + "partner":"6g6c" }, { "sim":0.996900022, @@ -157144,64 +157542,64 @@ "partner":"7bav" }, { - "sim":0.9965999722, - "partner":"6g6g" + "sim":0.9968000054, + "partner":"6g6a" }, { - "sim":0.9650999904, - "partner":"6g6c" + "sim":1.0, + "partner":"7baw" }, { - "sim":0.9988999963, - "partner":"7nfg" + "sim":1.0, + "partner":"7bat" }, { - "sim":1.0, - "partner":"7nfi" + "sim":0.9900000095, + "partner":"6g67" }, { - "sim":0.9947000146, - "partner":"7bau" + "sim":0.9883000255, + "partner":"6g65" }, { - "sim":0.991599977, - "partner":"7bo9" + "sim":0.9919999838, + "partner":"6g66" }, { - "sim":0.9883000255, - "partner":"6g65" + "sim":0.9988999963, + "partner":"7nfg" }, { - "sim":0.9900000095, - "partner":"6g67" + "sim":0.9947000146, + "partner":"7bau" }, { - "sim":1.0, - "partner":"6g6d" + "sim":0.9635999799, + "partner":"6g69" }, { - "sim":0.9919999838, - "partner":"6g66" + "sim":1.0, + "partner":"6g6d" }, { "sim":0.9905999899, "partner":"7boa" }, { - "sim":0.9732999802, - "partner":"8qac" + "sim":0.991599977, + "partner":"7bo9" }, { - "sim":0.9732999802, - "partner":"8qaa" + "sim":0.97299999, + "partner":"6yaz" }, { - "sim":0.9635999799, - "partner":"6g69" + "sim":0.9732999802, + "partner":"8qaa" }, { - "sim":0.97299999, - "partner":"6yaz" + "sim":0.9732999802, + "partner":"8qac" }, { "sim":0.9968000054, @@ -157276,84 +157674,84 @@ "tags":[ "de novo protein", "coiled coil", - "heptamer", - "de novo design" + "de novo design", + "heptamer" ], "keywords":[ - "variant", - "framework", - "seven", - "facile", - "allows", - "acetate", - "tests", - "chains", - "improve", - "incorporation", - "functional", - "proteins", - "accepts", "construction", - "helices", - "accessible", + "accepts", + "flexibility", + "improve", + "triad", + "hydrolytic", + "engineered", + "design", "redesigned", - "truly", - "chemical", - "also", - "report", + "probe", + "show", + "mutations", + "thermostable", + "predictable", "de", - "novo", - "catalysts", - "unnatural", - "catalytic", - "barrel", - "hydrolyses", - "biochemical", - "scaffolds", - "acid", - "biocatalysts", - "channel", - "efficiencies", - "engineered", - "resulting", + "lumen", + "functional", + "natural", + "around", + "first", + "21", + "side", + "based", + "accessible", + "comprises", "residues", - "robust", - "mutations", - "flexibility", "synthesis", - "activity", - "triads", - "hydrolytic", - "comprises", - "system", - "hydrolases", + "acid", + "helix", + "variant", + "scaffolds", "polar", - "match", - "show", + "resulting", + "report", + "framework", + "also", + "efficiencies", + "protein", "relationships", - "design", + "hydrolases", + "understanding", + "completely", + "biochemical", + "proteins", "install", + "biocatalysts", + "allows", + "unnatural", "arranged", - "lumen", - "based", - "mechanism", - "protein", - "21", - "probe", + "holds", + "novo", + "activity", + "system", + "tests", + "seven", + "match", + "hydrolyses", + "catalytic", "promise", + "channel", + "triads", + "acetate", "applications", - "predictable", - "natural", - "helix", - "holds", - "understanding", - "completely", - "side", - "first", - "around", - "thermostable", + "chemical", "predictably", - "triad" + "helices", + "incorporation", + "chains", + "barrel", + "mechanism", + "truly", + "robust", + "catalysts", + "facile" ], "release_date":"2016-07-06", "publication":"\"Installing hydrolytic activity into a completely de novo protein framework\", Nat.Chem., 8, 837-844", @@ -157651,8 +158049,8 @@ ], "subtitle":"Nano-ring of cadmium ions coordinated by nvpizza2-s16s58", "tags":[ - "metal coordination complex", "de novo protein", + "metal coordination complex", "self-assembly", "computational protein design" ], @@ -157695,11 +158093,11 @@ }, { "sim":173.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":173.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":172.0, @@ -157711,19 +158109,19 @@ }, { "sim":166.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":166.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":166.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":166.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":166.0, @@ -157731,11 +158129,11 @@ }, { "sim":166.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":166.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":166.0, @@ -157743,7 +158141,7 @@ }, { "sim":166.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":165.0, @@ -157755,15 +158153,15 @@ }, { "sim":164.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":164.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":164.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":164.0, @@ -157771,15 +158169,15 @@ }, { "sim":163.0, - "partner":"7zcj" + "partner":"7zq2" }, { "sim":163.0, - "partner":"7zq2" + "partner":"7zqg" }, { "sim":163.0, - "partner":"7zqg" + "partner":"7zcj" }, { "sim":161.0, @@ -157799,11 +158197,11 @@ }, { "sim":160.0, - "partner":"6i3a" + "partner":"6i39" }, { "sim":160.0, - "partner":"6i39" + "partner":"6i3a" }, { "sim":160.0, @@ -157815,11 +158213,11 @@ }, { "sim":156.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":156.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":156.0, @@ -157827,17 +158225,17 @@ }, { "sim":156.0, - "partner":"6ren" + "partner":"6reo" } ], "seq_thr_sim_natural":[ { "sim":123.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":123.0, - "partner":"1rwi" + "partner":"1rwl" } ], "struct_thr_sim_designed":[ @@ -157987,7 +158385,7 @@ }, "seq_max_sim_natural":{ "sim":123.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9866999984, @@ -158033,8 +158431,8 @@ ], "subtitle":"Solution nmr structure of de novo designed ploop2x3_50 fold protein, northeast structural genomics consortium (nesg) target or258", "tags":[ - "de novo protein", "nesg", + "de novo protein", "northeast structural genomics consortium", "psi-biology" ], @@ -158181,100 +158579,100 @@ "subtitle":"Crystal structure of a repeat protein with two protein a-dhr14 repeat modules", "tags":[ "immune system, de novo protein", - "synthetic protein", + "de novo protein", "immune system", - "de novo protein" + "synthetic protein" ], "keywords":[ - "rely", - "available", - "joining", - "designed", - "curved", - "requires", - "shapes", + "escherichia", + "molecular", + "repeat", "methods", + "single", + "via", + "extended", + "protein", + "readily", + "propose", + "assembling", + "continuous", + "produced", + "extensive", + "preexisting", + "expected", + "two", "crystal", - "shared", - "sequences", - "expand", + "stable", + "helices", + "using", + "either", + "creating", + "complex", + "program", + "formed", + "predictable", "connecting", - "repeating", - "turns", - "repeat", - "alpha", - "escherichia", + "rigid", + "helix", + "fused", "intended", - "novel", - "generating", - "trial", "proteins", - "usefulness", - "program", + "turns", + "several", + "joining", + "units", + "shapes", + "highly", + "available", + "components", + "stabilize", + "termini", + "pairs", "superimposed", - "efficient", "crystallized", - "dramatically", - "highly", - "simple", - "rigid", - "guarantee", - "currently", - "units", - "structures", - "complicated", - "predictable", + "fusion", "natural", - "pairs", + "simple", "assembly", - "either", - "fusion", - "extensive", - "assembling", - "molecular", - "expected", - "demonstrated", + "ligation", + "successful", "amino", - "via", - "components", - "assemblies", + "alpha", + "formation", + "complicated", "coli", - "extended", - "calculations", - "continuous", - "artificial", - "method", - "acids", - "fused", - "would", - "successful", - "stabilize", - "several", - "error", - "produced", - "using", - "propose", + "trial", + "requires", + "demonstrated", + "repertoire", + "expand", + "generating", "describe", + "assemblies", + "method", + "usefulness", + "prove", + "shared", "could", - "formation", - "helices", + "designed", + "calculations", "chose", - "stable", - "single", - "preexisting", + "sequences", + "efficient", + "curved", + "repeating", + "structures", + "rely", "copies", - "two", - "repertoire", - "creating", - "prove", - "protein", - "termini", - "complex", - "helix", - "readily", - "ligation", + "guarantee", + "would", + "artificial", + "dramatically", "graphics", - "formed" + "acids", + "error", + "currently", + "novel" ], "release_date":"2017-06-28", "publication":"\"Construction of novel repeat proteins with rigid and predictable structures using a shared helix method\", Sci Rep, 7, 2595-2595", @@ -158406,86 +158804,86 @@ "fullerene protein complex" ], "keywords":[ - "insulating", - "geometrically", - "periodic", - "ordered", - "fullerene", - "suggest", - "lattice", - "organizing", - "crystal", - "findings", - "precise", - "structure", - "rich", "affinity", - "associate", - "direct", - "tailored", - "proteins", - "rendering", - "tetramers", - "organization", - "binds", - "motif", - "nanomolar", - "solution", - "tyr", - "assembly", - "revealed", - "molecules", - "strikingly", - "previously", - "properties", - "taken", - "promoting", + "buckminsterfullerene", + "learning", + "matter", + "new", "exhibits", "superstructures", - "generate", - "occupy", - "c60", "amorphous", - "would", - "engineer", - "matter", - "compatible", - "bundle", - "lattices", - "design", + "strikingly", + "protein", "helical", - "soluble", - "high", - "known", - "learning", + "motif", + "together", "tetrameric", - "range", - "sites", - "buckminsterfullerene", + "promoting", + "site", "demonstrate", - "one", - "conductance", + "two", + "variety", + "precise", + "crystal", + "binds", + "adjacent", + "water", + "occupy", + "engineered", + "taken", + "organization", + "periodic", + "soluble", + "residues", + "charge", + "tyr", + "proteins", + "sites", + "tetramers", + "suggest", + "lattices", + "nanomolar", + "bundle", + "direct", + "design", + "insulating", + "associate", + "assembly", + "properties", + "rich", "groups", - "estimated", - "sandwiched", + "solution", + "incorporating", + "fullerene", + "crystals", + "organizing", + "geometrically", + "whereas", + "range", + "engineer", + "conductance", + "revealed", "electrically", + "one", + "tailored", + "previously", + "structure", + "findings", + "c60", "means", - "together", + "known", + "compatible", + "would", + "molecules", "enable", - "charge", - "engineered", - "residues", - "adjacent", - "two", - "incorporating", - "protein", - "variety", - "water", - "site", + "lattice", + "sandwiched", + "rendering", + "high", + "estimated", "create", - "crystals", - "new", - "whereas" + "ordered", + "generate" ], "release_date":"2016-05-04", "publication":"\"Protein-directed self-assembly of a fullerene crystal\", Nat Commun, 7, 11429-11429", @@ -158638,86 +159036,86 @@ "fullerene protein complex" ], "keywords":[ - "insulating", - "geometrically", - "periodic", - "ordered", - "fullerene", - "suggest", - "lattice", - "organizing", - "crystal", - "findings", - "precise", - "structure", - "rich", "affinity", - "associate", - "direct", - "tailored", - "proteins", - "rendering", - "tetramers", - "organization", - "binds", - "motif", - "nanomolar", - "solution", - "tyr", - "assembly", - "revealed", - "molecules", - "strikingly", - "previously", - "properties", - "taken", - "promoting", + "buckminsterfullerene", + "learning", + "matter", + "new", "exhibits", "superstructures", - "generate", - "occupy", - "c60", "amorphous", - "would", - "engineer", - "matter", - "compatible", - "bundle", - "lattices", - "design", + "strikingly", + "protein", "helical", - "soluble", - "high", - "known", - "learning", + "motif", + "together", "tetrameric", - "range", - "sites", - "buckminsterfullerene", + "promoting", + "site", "demonstrate", - "one", - "conductance", + "two", + "variety", + "precise", + "crystal", + "binds", + "adjacent", + "water", + "occupy", + "engineered", + "taken", + "organization", + "periodic", + "soluble", + "residues", + "charge", + "tyr", + "proteins", + "sites", + "tetramers", + "suggest", + "lattices", + "nanomolar", + "bundle", + "direct", + "design", + "insulating", + "associate", + "assembly", + "properties", + "rich", "groups", - "estimated", - "sandwiched", + "solution", + "incorporating", + "fullerene", + "crystals", + "organizing", + "geometrically", + "whereas", + "range", + "engineer", + "conductance", + "revealed", "electrically", + "one", + "tailored", + "previously", + "structure", + "findings", + "c60", "means", - "together", + "known", + "compatible", + "would", + "molecules", "enable", - "charge", - "engineered", - "residues", - "adjacent", - "two", - "incorporating", - "protein", - "variety", - "water", - "site", + "lattice", + "sandwiched", + "rendering", + "high", + "estimated", "create", - "crystals", - "new", - "whereas" + "ordered", + "generate" ], "release_date":"2016-05-04", "publication":"\"Protein-directed self-assembly of a fullerene crystal\", Nat Commun, 7, 11429-11429", @@ -158836,43 +159234,43 @@ ], "subtitle":"A circularly permuted pdua forming an icosahedral cage", "tags":[ - "bmc", - "microcompartment", - "design", - "icosahedron", + "mcp", "de novo protein", + "design", + "pdua", + "bmc", "protein design", + "icosahedron", "cage", - "pdua", - "mcp" + "microcompartment" ], "keywords":[ - "data", - "microcompartment", - "results", - "studies", - "conditions", - "cage", - "report", "opening", - "dependence", - "illustrate", - "version", - "shell", - "crystal", - "pdu", - "protein", - "applications", "natural", - "solution", - "structure", "assembly", - "dodecahedral", - "novel", - "nanotechnology", + "structure", "pdua", + "report", + "results", + "new", + "nanotechnology", + "protein", "biophysical", - "new" + "illustrate", + "dodecahedral", + "solution", + "version", + "conditions", + "pdu", + "cage", + "microcompartment", + "studies", + "data", + "applications", + "crystal", + "shell", + "dependence", + "novel" ], "release_date":"2016-04-06", "publication":"\"Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein\", Chem.Commun.(Camb.), 52, 5041-5044", @@ -159020,15 +159418,15 @@ }, { "sim":72.0, - "partner":"2ewh" + "partner":"3h8y" }, { "sim":72.0, - "partner":"2g13" + "partner":"2ewh" }, { "sim":72.0, - "partner":"3h8y" + "partner":"2g13" }, { "sim":61.0, @@ -159154,84 +159552,84 @@ "designed oligomeric interface" ], "keywords":[ - "cyclically", - "use", + "probe", + "repeat", "complexes", - "scattering", - "close", "idealized", "roles", - "experimentally", - "crystal", - "probe", + "newly", "assess", - "repeat", - "monomer", - "consistent", - "cyclic", - "direct", - "interfaces", + "new", + "model", + "protein", + "homotetramers", + "six", + "rapid", + "close", + "cyclically", "general", - "proteins", - "models", + "crystal", + "stable", + "corresponding", + "monodisperse", "play", - "designability", "characterized", + "formed", + "enumeration", + "experimentally", + "biological", + "consistent", + "cyclic", + "approach", + "proteins", + "use", + "scattering", "interface", - "ability", - "onto", - "structures", - "21", - "solution", - "corresponding", - "function", - "assembly", - "biology", - "form", - "rapid", - "data", - "obtained", - "newly", - "sufficiently", - "generate", - "report", + "found", + "15", + "monomer", "four", - "method", - "approaches", - "six", - "design", - "model", - "followed", - "96", + "sufficiently", + "computational", + "obtained", + "direct", "symmetry", + "design", + "onto", + "biology", + "assembly", + "designability", + "employs", + "solution", + "ability", "sequence", - "biological", "homotrimers", + "docked", + "96", + "method", "could", + "form", + "models", + "interfaces", + "custom", + "one", + "structures", + "approaches", + "21", "important", - "employs", + "possess", + "report", + "followed", + "function", + "homodimers", "homopentamer", - "designs", - "one", - "monodisperse", - "approach", - "stable", + "systematic", "enable", - "custom", - "found", + "data", "arrangements", - "systematic", - "protein", - "enumeration", - "possess", - "15", - "homodimers", - "docked", - "computational", - "homotetramers", - "formed", - "five", - "new" + "designs", + "generate", + "five" ], "release_date":"2017-04-12", "publication":"\"Computational design of self-assembling cyclic protein homo-oligomers\", Nat Chem, 9, 353-360", @@ -159312,11 +159710,11 @@ }, { "sim":179.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":179.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":179.0, @@ -159416,19 +159814,19 @@ }, { "sim":169.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":169.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":169.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":169.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":169.0, @@ -159436,35 +159834,35 @@ }, { "sim":169.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":169.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":169.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":169.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":169.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":169.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":169.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":169.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":168.0, @@ -159552,7 +159950,7 @@ }, { "sim":162.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":162.0, @@ -159560,7 +159958,7 @@ }, { "sim":162.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":161.0, @@ -159586,21 +159984,25 @@ "sim":139.0, "partner":"8hkh" }, + { + "sim":138.0, + "partner":"7z73" + }, { "sim":138.0, "partner":"8rci" }, { "sim":138.0, - "partner":"7z73" + "partner":"7b4u" }, { "sim":138.0, "partner":"7b4v" }, { - "sim":138.0, - "partner":"7b4u" + "sim":135.0, + "partner":"9glq" }, { "sim":135.0, @@ -159684,10 +160086,6 @@ "sim":172.0, "partner":"5aq8" }, - { - "sim":171.0, - "partner":"5eno" - }, { "sim":171.0, "partner":"4dx6" @@ -159768,6 +160166,10 @@ "sim":171.0, "partner":"4dx5" }, + { + "sim":171.0, + "partner":"5eno" + }, { "sim":170.0, "partner":"5aq9" @@ -159834,11 +160236,11 @@ }, { "sim":161.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":161.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":160.0, @@ -160002,15 +160404,15 @@ }, { "sim":103.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":103.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":103.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":102.0, @@ -160046,11 +160448,11 @@ }, { "sim":97.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":97.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":96.0, @@ -160078,15 +160480,15 @@ }, { "sim":94.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":94.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":94.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":94.0, @@ -160266,11 +160668,11 @@ }, { "sim":79.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":79.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":78.0, @@ -160278,15 +160680,15 @@ }, { "sim":78.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":78.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":78.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":78.0, @@ -160348,10 +160750,6 @@ "sim":63.0, "partner":"4ot9" }, - { - "sim":62.0, - "partner":"5iwr" - }, { "sim":62.0, "partner":"5iwt" @@ -160364,6 +160762,10 @@ "sim":62.0, "partner":"5iwp" }, + { + "sim":62.0, + "partner":"5iwr" + }, { "sim":57.0, "partner":"2pnn" @@ -160435,6 +160837,10 @@ { "sim":50.0, "partner":"5an8" + }, + { + "sim":50.0, + "partner":"8ycp" } ], "struct_thr_sim_designed":[ @@ -160595,84 +161001,84 @@ "designed oligomeric interface" ], "keywords":[ - "cyclically", - "use", + "probe", + "repeat", "complexes", - "scattering", - "close", "idealized", "roles", - "experimentally", - "crystal", - "probe", + "newly", "assess", - "repeat", - "monomer", - "consistent", - "cyclic", - "direct", - "interfaces", + "new", + "model", + "protein", + "homotetramers", + "six", + "rapid", + "close", + "cyclically", "general", - "proteins", - "models", + "crystal", + "stable", + "corresponding", + "monodisperse", "play", - "designability", "characterized", + "formed", + "enumeration", + "experimentally", + "biological", + "consistent", + "cyclic", + "approach", + "proteins", + "use", + "scattering", "interface", - "ability", - "onto", - "structures", - "21", - "solution", - "corresponding", - "function", - "assembly", - "biology", - "form", - "rapid", - "data", - "obtained", - "newly", - "sufficiently", - "generate", - "report", + "found", + "15", + "monomer", "four", - "method", - "approaches", - "six", - "design", - "model", - "followed", - "96", + "sufficiently", + "computational", + "obtained", + "direct", "symmetry", + "design", + "onto", + "biology", + "assembly", + "designability", + "employs", + "solution", + "ability", "sequence", - "biological", "homotrimers", + "docked", + "96", + "method", "could", + "form", + "models", + "interfaces", + "custom", + "one", + "structures", + "approaches", + "21", "important", - "employs", + "possess", + "report", + "followed", + "function", + "homodimers", "homopentamer", - "designs", - "one", - "monodisperse", - "approach", - "stable", + "systematic", "enable", - "custom", - "found", + "data", "arrangements", - "systematic", - "protein", - "enumeration", - "possess", - "15", - "homodimers", - "docked", - "computational", - "homotetramers", - "formed", - "five", - "new" + "designs", + "generate", + "five" ], "release_date":"2017-04-12", "publication":"\"Computational design of self-assembling cyclic protein homo-oligomers\", Nat Chem, 9, 353-360", @@ -160729,11 +161135,11 @@ }, { "sim":184.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":184.0, - "partner":"8cqq" + "partner":"8cqp" }, { "sim":184.0, @@ -160741,27 +161147,27 @@ }, { "sim":184.0, - "partner":"8chy" + "partner":"8cmq" }, { "sim":184.0, - "partner":"8cmq" + "partner":"8bu0" }, { "sim":184.0, - "partner":"8ckr" + "partner":"8cp8" }, { "sim":184.0, - "partner":"8cig" + "partner":"8cqq" }, { "sim":184.0, - "partner":"8cqp" + "partner":"8chy" }, { "sim":184.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":182.0, @@ -160769,11 +161175,11 @@ }, { "sim":181.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":181.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":179.0, @@ -160789,15 +161195,15 @@ }, { "sim":85.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":85.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":85.0, - "partner":"8cus" + "partner":"8cwz" } ], "seq_thr_sim_natural":[ @@ -160933,84 +161339,84 @@ "designed oligomeric interface" ], "keywords":[ - "cyclically", - "use", + "probe", + "repeat", "complexes", - "scattering", - "close", "idealized", "roles", - "experimentally", - "crystal", - "probe", + "newly", "assess", - "repeat", - "monomer", - "consistent", - "cyclic", - "direct", - "interfaces", + "new", + "model", + "protein", + "homotetramers", + "six", + "rapid", + "close", + "cyclically", "general", - "proteins", - "models", + "crystal", + "stable", + "corresponding", + "monodisperse", "play", - "designability", "characterized", + "formed", + "enumeration", + "experimentally", + "biological", + "consistent", + "cyclic", + "approach", + "proteins", + "use", + "scattering", "interface", - "ability", - "onto", - "structures", - "21", - "solution", - "corresponding", - "function", - "assembly", - "biology", - "form", - "rapid", - "data", - "obtained", - "newly", - "sufficiently", - "generate", - "report", + "found", + "15", + "monomer", "four", - "method", - "approaches", - "six", - "design", - "model", - "followed", - "96", + "sufficiently", + "computational", + "obtained", + "direct", "symmetry", + "design", + "onto", + "biology", + "assembly", + "designability", + "employs", + "solution", + "ability", "sequence", - "biological", "homotrimers", + "docked", + "96", + "method", "could", + "form", + "models", + "interfaces", + "custom", + "one", + "structures", + "approaches", + "21", "important", - "employs", + "possess", + "report", + "followed", + "function", + "homodimers", "homopentamer", - "designs", - "one", - "monodisperse", - "approach", - "stable", + "systematic", "enable", - "custom", - "found", + "data", "arrangements", - "systematic", - "protein", - "enumeration", - "possess", - "15", - "homodimers", - "docked", - "computational", - "homotetramers", - "formed", - "five", - "new" + "designs", + "generate", + "five" ], "release_date":"2017-04-12", "publication":"\"Computational design of self-assembling cyclic protein homo-oligomers\", Nat Chem, 9, 353-360", @@ -161139,11 +161545,11 @@ }, { "sim":161.0, - "partner":"7zyu" + "partner":"7z7c" }, { "sim":161.0, - "partner":"7z7c" + "partner":"7zyu" }, { "sim":161.0, @@ -161151,11 +161557,11 @@ }, { "sim":161.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":161.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":161.0, @@ -161187,11 +161593,11 @@ }, { "sim":158.0, - "partner":"4ydw" + "partner":"5kng" }, { "sim":158.0, - "partner":"5kng" + "partner":"4ydw" }, { "sim":158.0, @@ -161259,7 +161665,7 @@ }, { "sim":153.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":153.0, @@ -161267,7 +161673,7 @@ }, { "sim":153.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":152.0, @@ -161287,19 +161693,19 @@ }, { "sim":151.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":151.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":151.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":151.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":151.0, @@ -161307,35 +161713,35 @@ }, { "sim":151.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":151.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":151.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":151.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":151.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":151.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":151.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":151.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":151.0, @@ -161383,12 +161789,16 @@ }, { "sim":115.0, - "partner":"7b4v" + "partner":"9glq" }, { "sim":115.0, "partner":"7b4u" }, + { + "sim":115.0, + "partner":"7b4v" + }, { "sim":110.0, "partner":"9f24" @@ -161479,10 +161889,6 @@ "sim":157.0, "partner":"5aq8" }, - { - "sim":156.0, - "partner":"5eno" - }, { "sim":156.0, "partner":"4dx6" @@ -161555,6 +161961,10 @@ "sim":156.0, "partner":"4dx5" }, + { + "sim":156.0, + "partner":"5eno" + }, { "sim":155.0, "partner":"1svx" @@ -161601,11 +162011,11 @@ }, { "sim":147.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":147.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":145.0, @@ -161733,15 +162143,15 @@ }, { "sim":107.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":107.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":107.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":106.0, @@ -161789,11 +162199,11 @@ }, { "sim":101.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":101.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":100.0, @@ -161877,11 +162287,11 @@ }, { "sim":91.0, - "partner":"1g3n" + "partner":"5eid" }, { "sim":91.0, - "partner":"5eid" + "partner":"1g3n" }, { "sim":91.0, @@ -161893,11 +162303,11 @@ }, { "sim":90.0, - "partner":"1ap7" + "partner":"1mx6" }, { "sim":90.0, - "partner":"1mx6" + "partner":"1ap7" }, { "sim":89.0, @@ -161985,11 +162395,11 @@ }, { "sim":84.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":84.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":83.0, @@ -162171,10 +162581,6 @@ "sim":63.0, "partner":"3ui2" }, - { - "sim":63.0, - "partner":"5iwr" - }, { "sim":63.0, "partner":"5iwt" @@ -162187,6 +162593,10 @@ "sim":63.0, "partner":"5iwp" }, + { + "sim":63.0, + "partner":"5iwr" + }, { "sim":62.0, "partner":"5d68" @@ -162301,10 +162711,10 @@ ], "subtitle":"Nvpizza2-h16s58 with cobalt", "tags":[ - "artificial", - "strand exchange", "de novo protein", "domain swapping", + "strand exchange", + "artificial", "symmetrical homo-oligomer" ], "keywords":[ @@ -162362,15 +162772,15 @@ }, { "sim":167.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":167.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":167.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":167.0, @@ -162378,19 +162788,19 @@ }, { "sim":164.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":164.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":164.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":164.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":164.0, @@ -162398,11 +162808,11 @@ }, { "sim":164.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":164.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":164.0, @@ -162410,15 +162820,15 @@ }, { "sim":164.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":163.0, - "partner":"7zcj" + "partner":"6f0t" }, { "sim":163.0, - "partner":"6f0t" + "partner":"7zcj" }, { "sim":162.0, @@ -162450,23 +162860,23 @@ }, { "sim":158.0, - "partner":"6i3a" + "partner":"6i39" }, { "sim":158.0, - "partner":"6i39" + "partner":"6i3a" }, { "sim":158.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":158.0, - "partner":"6rli" + "partner":"7zph" }, { "sim":158.0, - "partner":"6rlh" + "partner":"6ren" }, { "sim":158.0, @@ -162474,32 +162884,32 @@ }, { "sim":158.0, - "partner":"7zph" + "partner":"6rlh" }, { "sim":158.0, - "partner":"6ren" + "partner":"6reo" } ], "seq_thr_sim_natural":[ { "sim":123.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":123.0, - "partner":"1rwi" + "partner":"1rwl" } ], "struct_thr_sim_designed":[ - { - "sim":0.9914000034, - "partner":"5i1z" - }, { "sim":0.972299993, "partner":"4zcn" }, + { + "sim":0.9914000034, + "partner":"5i1z" + }, { "sim":0.9743999839, "partner":"5f53" @@ -162622,7 +163032,7 @@ }, "seq_max_sim_natural":{ "sim":123.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9914000034, @@ -162696,10 +163106,10 @@ ], "subtitle":"Structure of nvpizza2-h16s58", "tags":[ - "artificial", - "strand exchange", "de novo protein", "domain swapping", + "strand exchange", + "artificial", "symmetrical homo-oligomer" ], "keywords":[ @@ -162757,15 +163167,15 @@ }, { "sim":167.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":167.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":167.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":167.0, @@ -162773,19 +163183,19 @@ }, { "sim":164.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":164.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":164.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":164.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":164.0, @@ -162793,11 +163203,11 @@ }, { "sim":164.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":164.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":164.0, @@ -162805,15 +163215,15 @@ }, { "sim":164.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":163.0, - "partner":"7zcj" + "partner":"6f0t" }, { "sim":163.0, - "partner":"6f0t" + "partner":"7zcj" }, { "sim":162.0, @@ -162845,23 +163255,23 @@ }, { "sim":158.0, - "partner":"6i3a" + "partner":"6i39" }, { "sim":158.0, - "partner":"6i39" + "partner":"6i3a" }, { "sim":158.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":158.0, - "partner":"6rli" + "partner":"7zph" }, { "sim":158.0, - "partner":"6rlh" + "partner":"6ren" }, { "sim":158.0, @@ -162869,21 +163279,21 @@ }, { "sim":158.0, - "partner":"7zph" + "partner":"6rlh" }, { "sim":158.0, - "partner":"6ren" + "partner":"6reo" } ], "seq_thr_sim_natural":[ { "sim":123.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":123.0, - "partner":"1rwi" + "partner":"1rwl" } ], "struct_thr_sim_designed":[ @@ -163033,7 +163443,7 @@ }, "seq_max_sim_natural":{ "sim":123.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9961000085, @@ -163127,82 +163537,82 @@ ], "subtitle":"Crystal structure of designed pentatricopeptide repeat protein dppr-u8a2 in complex with its target rna u8a2", "tags":[ - "designer pentatricopeptide repeat protein", - "single-stranded rna", "rna binding protein", + "rna binding protein\/rna", "rna binding protein-rna complex", - "rna binding protein\/rna" + "designer pentatricopeptide repeat protein", + "single-stranded rna" ], "keywords":[ - "ppr", - "pentatricopeptide", - "embraces", + "c", + "repeats", + "complex", + "superhelical", + "open", + "path", "molecular", + "recognition", + "design", + "however", + "structural", + "insights", + "atomic", "u", - "manipulation", - "functional", - "proteins", - "large", - "gene", - "multiple", - "aspects", - "revealing", - "patterns", - "also", - "report", - "rna", - "dppr", - "study", - "family", - "modules", - "four", + "repeat", + "observed", "rnas", - "eukaryotes", - "bases", - "modular", + "structures", + "ssrnas", + "codes", "elucidated", - "open", - "shell", + "multiple", + "functional", "different", + "rna", + "potential", + "gene", "remains", + "respective", + "specific", + "synthetic", + "family", + "report", + "targets", + "level", "serve", + "revealing", "provide", - "recognition", - "towards", - "specific", - "crystal", - "potential", + "also", "target", - "observed", - "design", - "ssrna", - "basis", - "ssrnas", - "structures", "assembled", - "superhelical", + "eukaryotes", + "designable", + "ppr", + "embraces", "interactions", - "synthetic", - "complex", - "respective", - "targets", - "path", - "atomic", - "c", - "repeat", - "repeats", - "codes", - "insights", - "spiral", + "study", + "basis", + "patterns", + "large", + "proteins", + "binding", + "modules", + "pentatricopeptide", "metabolism", "mediate", - "designable", - "however", - "binding", - "structural", - "designer", "fashion", - "level" + "modular", + "dppr", + "towards", + "designer", + "spiral", + "manipulation", + "aspects", + "crystal", + "shell", + "four", + "ssrna", + "bases" ], "release_date":"2016-04-27", "publication":"\"Structural basis for specific single-stranded RNA recognition by designer pentatricopeptide repeat proteins\", Nat Commun, 7, 11285-11285", @@ -163341,81 +163751,81 @@ ], "subtitle":"Crystal structure of designed pentatricopeptide repeat protein dppr-u10 in complex with its target rna u10", "tags":[ - "rna binding protein-rna complex", "designer pentatricopeptide repeat protein", "single-stranded rna", + "rna binding protein-rna complex", "rna binding protein\/rna" ], "keywords":[ - "ppr", - "pentatricopeptide", - "embraces", + "c", + "repeats", + "complex", + "superhelical", + "open", + "path", "molecular", + "recognition", + "design", + "however", + "structural", + "insights", + "atomic", "u", - "manipulation", - "functional", - "proteins", - "large", - "gene", - "multiple", - "aspects", - "revealing", - "patterns", - "also", - "report", - "rna", - "dppr", - "study", - "family", - "modules", - "four", + "repeat", + "observed", "rnas", - "eukaryotes", - "bases", - "modular", + "structures", + "ssrnas", + "codes", "elucidated", - "open", - "shell", + "multiple", + "functional", "different", + "rna", + "potential", + "gene", "remains", + "respective", + "specific", + "synthetic", + "family", + "report", + "targets", + "level", "serve", + "revealing", "provide", - "recognition", - "towards", - "specific", - "crystal", - "potential", + "also", "target", - "observed", - "design", - "ssrna", - "basis", - "ssrnas", - "structures", "assembled", - "superhelical", + "eukaryotes", + "designable", + "ppr", + "embraces", "interactions", - "synthetic", - "complex", - "respective", - "targets", - "path", - "atomic", - "c", - "repeat", - "repeats", - "codes", - "insights", - "spiral", + "study", + "basis", + "patterns", + "large", + "proteins", + "binding", + "modules", + "pentatricopeptide", "metabolism", "mediate", - "designable", - "however", - "binding", - "structural", - "designer", "fashion", - "level" + "modular", + "dppr", + "towards", + "designer", + "spiral", + "manipulation", + "aspects", + "crystal", + "shell", + "four", + "ssrna", + "bases" ], "release_date":"2016-04-27", "publication":"\"Structural basis for specific single-stranded RNA recognition by designer pentatricopeptide repeat proteins\", Nat Commun, 7, 11285-11285", @@ -163553,81 +163963,81 @@ ], "subtitle":"Crystal structure of designed pentatricopeptide repeat protein dppr-u8c2 in complex with its target rna u8c2", "tags":[ - "rna binding protein-rna complex", "designer pentatricopeptide repeat protein", "single-stranded rna", + "rna binding protein-rna complex", "rna binding protein\/rna" ], "keywords":[ - "ppr", - "pentatricopeptide", - "embraces", + "c", + "repeats", + "complex", + "superhelical", + "open", + "path", "molecular", + "recognition", + "design", + "however", + "structural", + "insights", + "atomic", "u", - "manipulation", - "functional", - "proteins", - "large", - "gene", - "multiple", - "aspects", - "revealing", - "patterns", - "also", - "report", - "rna", - "dppr", - "study", - "family", - "modules", - "four", + "repeat", + "observed", "rnas", - "eukaryotes", - "bases", - "modular", + "structures", + "ssrnas", + "codes", "elucidated", - "open", - "shell", + "multiple", + "functional", "different", + "rna", + "potential", + "gene", "remains", + "respective", + "specific", + "synthetic", + "family", + "report", + "targets", + "level", "serve", + "revealing", "provide", - "recognition", - "towards", - "specific", - "crystal", - "potential", + "also", "target", - "observed", - "design", - "ssrna", - "basis", - "ssrnas", - "structures", "assembled", - "superhelical", + "eukaryotes", + "designable", + "ppr", + "embraces", "interactions", - "synthetic", - "complex", - "respective", - "targets", - "path", - "atomic", - "c", - "repeat", - "repeats", - "codes", - "insights", - "spiral", + "study", + "basis", + "patterns", + "large", + "proteins", + "binding", + "modules", + "pentatricopeptide", "metabolism", "mediate", - "designable", - "however", - "binding", - "structural", - "designer", "fashion", - "level" + "modular", + "dppr", + "towards", + "designer", + "spiral", + "manipulation", + "aspects", + "crystal", + "shell", + "four", + "ssrna", + "bases" ], "release_date":"2016-04-27", "publication":"\"Structural basis for specific single-stranded RNA recognition by designer pentatricopeptide repeat proteins\", Nat Commun, 7, 11285-11285", @@ -163765,81 +164175,81 @@ ], "subtitle":"Crystal structure of designed pentatricopeptide repeat protein dppr-u8g2 in complex with its target rna u8g2", "tags":[ - "rna binding protein-rna complex", "designer pentatricopeptide repeat protein", "single-stranded rna", + "rna binding protein-rna complex", "rna binding protein\/rna" ], "keywords":[ - "ppr", - "pentatricopeptide", - "embraces", + "c", + "repeats", + "complex", + "superhelical", + "open", + "path", "molecular", + "recognition", + "design", + "however", + "structural", + "insights", + "atomic", "u", - "manipulation", - "functional", - "proteins", - "large", - "gene", - "multiple", - "aspects", - "revealing", - "patterns", - "also", - "report", - "rna", - "dppr", - "study", - "family", - "modules", - "four", + "repeat", + "observed", "rnas", - "eukaryotes", - "bases", - "modular", + "structures", + "ssrnas", + "codes", "elucidated", - "open", - "shell", + "multiple", + "functional", "different", + "rna", + "potential", + "gene", "remains", + "respective", + "specific", + "synthetic", + "family", + "report", + "targets", + "level", "serve", + "revealing", "provide", - "recognition", - "towards", - "specific", - "crystal", - "potential", + "also", "target", - "observed", - "design", - "ssrna", - "basis", - "ssrnas", - "structures", "assembled", - "superhelical", + "eukaryotes", + "designable", + "ppr", + "embraces", "interactions", - "synthetic", - "complex", - "respective", - "targets", - "path", - "atomic", - "c", - "repeat", - "repeats", - "codes", - "insights", - "spiral", + "study", + "basis", + "patterns", + "large", + "proteins", + "binding", + "modules", + "pentatricopeptide", "metabolism", "mediate", - "designable", - "however", - "binding", - "structural", - "designer", "fashion", - "level" + "modular", + "dppr", + "towards", + "designer", + "spiral", + "manipulation", + "aspects", + "crystal", + "shell", + "four", + "ssrna", + "bases" ], "release_date":"2016-04-27", "publication":"\"Structural basis for specific single-stranded RNA recognition by designer pentatricopeptide repeat proteins\", Nat Commun, 7, 11285-11285", @@ -163954,111 +164364,111 @@ ], "subtitle":"Structure of cdl2.2, a computationally designed vitamin-d3 binder", "tags":[ - "computational", - "structural genomics", - "de novo protein", "ligand binder", - "rossetta" + "rossetta", + "de novo protein", + "computational", + "structural genomics" ], "keywords":[ - "cases", - "part", - "change", - "constructs", - "represents", - "specificity", - "biochemical", - "designed", - "prediction", - "mutations", - "towards", - "improved", - "instead", - "sampling", + "affinity", + "complementarity", + "recognition", + "molecular", + "development", + "key", "tetrahydrocannabinol", - "bind", - "enhanced", + "collectively", + "originally", + "deviation", + "protein", + "biochemical", + "significantly", + "accurate", + "binding", + "focus", + "changes", + "novo", + "corresponding", + "simulations", "conformation", - "structure", - "display", + "engineered", + "equally", + "initial", + "conformational", + "specificity", + "due", "computationally", + "represents", + "ligand", + "unintended", + "particularly", + "helix", + "polar", + "although", + "led", "intended", - "affinity", - "novel", + "control", "contacts", - "altertion", + "optimization", + "bind", "proteins", - "de", - "although", - "area", - "focus", - "orientation", - "recognition", - "initial", - "often", - "particularly", - "dynamics", - "attempts", - "corresponding", - "significantly", - "exhibit", - "form", - "contribute", - "control", - "unexpected", - "thc", - "molecular", - "equally", "large", - "complementarity", - "selections", - "changes", - "unintended", - "accurate", - "optimization", - "shape", + "part", + "characterization", "may", - "movement", - "simulations", + "imply", + "found", + "subjected", + "moieties", + "combination", + "lack", + "pocket", "behavior", - "crystallographic", + "exhibit", + "enhanced", + "sampling", "design", - "characterization", - "indicate", - "key", + "movement", + "selections", + "instead", + "display", + "orientation", + "prediction", + "improved", "formation", - "led", + "backbone", + "compounds", "predicted", - "originally", - "ligand", - "imply", - "one", + "thc", "analyses", - "conformational", - "lack", - "novo", "desired", - "deviation", - "engineered", - "found", - "due", - "polar", - "significant", + "crystallographic", + "dynamics", + "designed", + "form", + "often", + "one", + "indicate", + "loop", + "mutations", + "constructs", + "de", "flank", - "protein", - "backbone", - "development", - "helix", - "collectively", - "compounds", - "combination", + "attempts", + "contribute", + "area", + "structure", + "shape", + "altertion", + "cases", + "change", + "towards", "distinct", - "subjected", - "pocket", - "moieties", - "binding", + "unexpected", "create", - "loop" + "novel", + "significant" ], "release_date":"2017-03-01", "publication":"\"Unintended specificity of an engineered ligand-binding protein facilitated by unpredicted plasticity of the protein fold\", Protein Eng.Des.Sel., 31, 375-387", @@ -164187,111 +164597,111 @@ ], "subtitle":"Structure of cdl2.3a, a computationally designed vitamin-d3 binder", "tags":[ - "computational", - "structural genomics", - "de novo protein", "ligand binder", - "rossetta" + "rossetta", + "de novo protein", + "computational", + "structural genomics" ], "keywords":[ - "cases", - "part", - "change", - "constructs", - "represents", - "specificity", - "biochemical", - "designed", - "prediction", - "mutations", - "towards", - "improved", - "instead", - "sampling", + "affinity", + "complementarity", + "recognition", + "molecular", + "development", + "key", "tetrahydrocannabinol", - "bind", - "enhanced", + "collectively", + "originally", + "deviation", + "protein", + "biochemical", + "significantly", + "accurate", + "binding", + "focus", + "changes", + "novo", + "corresponding", + "simulations", "conformation", - "structure", - "display", + "engineered", + "equally", + "initial", + "conformational", + "specificity", + "due", "computationally", + "represents", + "ligand", + "unintended", + "particularly", + "helix", + "polar", + "although", + "led", "intended", - "affinity", - "novel", + "control", "contacts", - "altertion", + "optimization", + "bind", "proteins", - "de", - "although", - "area", - "focus", - "orientation", - "recognition", - "initial", - "often", - "particularly", - "dynamics", - "attempts", - "corresponding", - "significantly", - "exhibit", - "form", - "contribute", - "control", - "unexpected", - "thc", - "molecular", - "equally", "large", - "complementarity", - "selections", - "changes", - "unintended", - "accurate", - "optimization", - "shape", + "part", + "characterization", "may", - "movement", - "simulations", + "imply", + "found", + "subjected", + "moieties", + "combination", + "lack", + "pocket", "behavior", - "crystallographic", + "exhibit", + "enhanced", + "sampling", "design", - "characterization", - "indicate", - "key", + "movement", + "selections", + "instead", + "display", + "orientation", + "prediction", + "improved", "formation", - "led", + "backbone", + "compounds", "predicted", - "originally", - "ligand", - "imply", - "one", + "thc", "analyses", - "conformational", - "lack", - "novo", "desired", - "deviation", - "engineered", - "found", - "due", - "polar", - "significant", + "crystallographic", + "dynamics", + "designed", + "form", + "often", + "one", + "indicate", + "loop", + "mutations", + "constructs", + "de", "flank", - "protein", - "backbone", - "development", - "helix", - "collectively", - "compounds", - "combination", + "attempts", + "contribute", + "area", + "structure", + "shape", + "altertion", + "cases", + "change", + "towards", "distinct", - "subjected", - "pocket", - "moieties", - "binding", + "unexpected", "create", - "loop" + "novel", + "significant" ], "release_date":"2017-03-01", "publication":"\"Unintended specificity of an engineered ligand-binding protein facilitated by unpredicted plasticity of the protein fold\", Protein Eng.Des.Sel., 31, 375-387", @@ -164423,111 +164833,111 @@ ], "subtitle":"Structure of cdl2.3b, a computationally designed vitamin-d3 binder", "tags":[ - "computational", - "structural genomics", - "de novo protein", "ligand binder", - "rossetta" + "rossetta", + "de novo protein", + "computational", + "structural genomics" ], "keywords":[ - "cases", - "part", - "change", - "constructs", - "represents", - "specificity", - "biochemical", - "designed", - "prediction", - "mutations", - "towards", - "improved", - "instead", - "sampling", + "affinity", + "complementarity", + "recognition", + "molecular", + "development", + "key", "tetrahydrocannabinol", - "bind", - "enhanced", + "collectively", + "originally", + "deviation", + "protein", + "biochemical", + "significantly", + "accurate", + "binding", + "focus", + "changes", + "novo", + "corresponding", + "simulations", "conformation", - "structure", - "display", + "engineered", + "equally", + "initial", + "conformational", + "specificity", + "due", "computationally", + "represents", + "ligand", + "unintended", + "particularly", + "helix", + "polar", + "although", + "led", "intended", - "affinity", - "novel", + "control", "contacts", - "altertion", + "optimization", + "bind", "proteins", - "de", - "although", - "area", - "focus", - "orientation", - "recognition", - "initial", - "often", - "particularly", - "dynamics", - "attempts", - "corresponding", - "significantly", - "exhibit", - "form", - "contribute", - "control", - "unexpected", - "thc", - "molecular", - "equally", "large", - "complementarity", - "selections", - "changes", - "unintended", - "accurate", - "optimization", - "shape", + "part", + "characterization", "may", - "movement", - "simulations", + "imply", + "found", + "subjected", + "moieties", + "combination", + "lack", + "pocket", "behavior", - "crystallographic", + "exhibit", + "enhanced", + "sampling", "design", - "characterization", - "indicate", - "key", + "movement", + "selections", + "instead", + "display", + "orientation", + "prediction", + "improved", "formation", - "led", + "backbone", + "compounds", "predicted", - "originally", - "ligand", - "imply", - "one", + "thc", "analyses", - "conformational", - "lack", - "novo", "desired", - "deviation", - "engineered", - "found", - "due", - "polar", - "significant", + "crystallographic", + "dynamics", + "designed", + "form", + "often", + "one", + "indicate", + "loop", + "mutations", + "constructs", + "de", "flank", - "protein", - "backbone", - "development", - "helix", - "collectively", - "compounds", - "combination", + "attempts", + "contribute", + "area", + "structure", + "shape", + "altertion", + "cases", + "change", + "towards", "distinct", - "subjected", - "pocket", - "moieties", - "binding", + "unexpected", "create", - "loop" + "novel", + "significant" ], "release_date":"2017-03-01", "publication":"\"Unintended specificity of an engineered ligand-binding protein facilitated by unpredicted plasticity of the protein fold\", Protein Eng.Des.Sel., 31, 375-387", @@ -164663,124 +165073,124 @@ ], "subtitle":"Structure of a computationally designed 17-ohp binder", "tags":[ - "computational", - "structural genomics", - "de novo protein", "ligand binder", - "rossetta" + "rossetta", + "de novo protein", + "computational", + "structural genomics" ], "keywords":[ - "hence", - "containing", - "thus", + "affinity", + "development", + "flipped", + "single", "multiple", - "modes", + "around", + "core", + "extended", + "within", + "model", + "protein", + "binding", + "changes", + "sources", + "carbonyl", + "appearing", + "site", + "subsequent", + "original", + "two", + "crystal", + "sidechain", "compound", - "exacerbated", - "constrain", - "selection", - "still", + "conformation", + "engineered", "congenital", - "designed", - "near", - "hormone", - "interact", - "improved", + "interacting", + "rotated", + "interest", + "discrepancy", + "distribution", "experimentally", - "crystal", - "energetic", - "sampling", + "ligand", + "modes", + "maintains", + "relative", + "thus", + "residues", + "polar", + "displays", "bind", - "conformation", - "flipped", - "structure", - "16", "axis", - "affinity", - "sidechain", - "molecule", - "base", - "original", - "hydroxyl", - "models", + "interact", + "sites", "proteins", - "rotated", - "desolvating", - "distribution", - "used", - "orientation", - "inaccuracies", - "site", - "sensors", - "maintains", - "bonding", - "alter", - "nanomolar", - "adrenal", - "function", - "revealed", - "cost", - "first", - "second", - "hydrogen", + "bound", + "eight", "rounds", - "considerable", - "subsequent", - "trace", - "generate", - "extended", - "changes", - "failure", - "biomarker", - "calculations", - "displays", - "limitations", - "interacting", - "interest", - "design", - "model", - "core", - "states", + "end", + "hydrogen", + "micromolar", + "nanomolar", + "computational", + "base", + "bonding", + "rotameric", + "molecule", + "mutagenesis", + "pocket", "symmetry", + "design", + "sampling", "energy", - "underestimation", - "carbonyl", - "around", - "range", - "sites", - "nonpolar", - "designs", - "ligand", - "steroid", - "eight", + "subtle", + "selection", + "used", + "energetic", + "hence", "tested", - "one", + "16", + "still", + "steroid", + "orientation", "groups", - "subtle", - "difference", - "micromolar", - "single", - "engineered", - "residues", + "nonpolar", + "improved", "hyperplasia", - "two", - "polar", - "rotameric", - "binding", - "protein", - "bound", "backbone", - "development", - "end", + "states", + "near", + "range", + "failure", + "designed", + "constrain", + "models", + "calculations", + "revealed", + "one", + "biomarker", + "first", + "hydroxyl", + "structure", + "function", + "hormone", + "exacerbated", + "cost", + "considerable", + "inaccuracies", + "underestimation", + "alter", + "trace", + "difference", + "desolvating", + "sensors", + "limitations", "arises", - "within", - "computational", - "pocket", - "relative", - "appearing", - "discrepancy", - "sources", - "mutagenesis" + "designs", + "second", + "containing", + "generate", + "adrenal" ], "release_date":"2017-03-01", "publication":"\"Sampling and energy evaluation challenges in ligand binding protein design\", Protein Sci., 26, 2426-2437", @@ -164817,10 +165227,6 @@ } ], "seq_thr_sim_natural":[ - { - "sim":265.0, - "partner":"2z77" - }, { "sim":265.0, "partner":"2z7a" @@ -164832,6 +165238,10 @@ { "sim":265.0, "partner":"2z76" + }, + { + "sim":265.0, + "partner":"2z77" } ], "struct_thr_sim_designed":[ @@ -164856,7 +165266,7 @@ }, "seq_max_sim_natural":{ "sim":265.0, - "partner":"2z77" + "partner":"2z7a" }, "struct_max_sim_designed":{ "sim":0.9690999985, @@ -164927,124 +165337,124 @@ ], "subtitle":"Structure of a computationally designed 17-ohp binder", "tags":[ - "computational", - "structural genomics", - "de novo protein", "ligand binder", - "rossetta" + "rossetta", + "de novo protein", + "computational", + "structural genomics" ], "keywords":[ - "hence", - "containing", - "thus", + "affinity", + "development", + "flipped", + "single", "multiple", - "modes", + "around", + "core", + "extended", + "within", + "model", + "protein", + "binding", + "changes", + "sources", + "carbonyl", + "appearing", + "site", + "subsequent", + "original", + "two", + "crystal", + "sidechain", "compound", - "exacerbated", - "constrain", - "selection", - "still", + "conformation", + "engineered", "congenital", - "designed", - "near", - "hormone", - "interact", - "improved", + "interacting", + "rotated", + "interest", + "discrepancy", + "distribution", "experimentally", - "crystal", - "energetic", - "sampling", + "ligand", + "modes", + "maintains", + "relative", + "thus", + "residues", + "polar", + "displays", "bind", - "conformation", - "flipped", - "structure", - "16", "axis", - "affinity", - "sidechain", - "molecule", - "base", - "original", - "hydroxyl", - "models", + "interact", + "sites", "proteins", - "rotated", - "desolvating", - "distribution", - "used", - "orientation", - "inaccuracies", - "site", - "sensors", - "maintains", - "bonding", - "alter", - "nanomolar", - "adrenal", - "function", - "revealed", - "cost", - "first", - "second", - "hydrogen", + "bound", + "eight", "rounds", - "considerable", - "subsequent", - "trace", - "generate", - "extended", - "changes", - "failure", - "biomarker", - "calculations", - "displays", - "limitations", - "interacting", - "interest", - "design", - "model", - "core", - "states", + "end", + "hydrogen", + "micromolar", + "nanomolar", + "computational", + "base", + "bonding", + "rotameric", + "molecule", + "mutagenesis", + "pocket", "symmetry", + "design", + "sampling", "energy", - "underestimation", - "carbonyl", - "around", - "range", - "sites", - "nonpolar", - "designs", - "ligand", - "steroid", - "eight", + "subtle", + "selection", + "used", + "energetic", + "hence", "tested", - "one", + "16", + "still", + "steroid", + "orientation", "groups", - "subtle", - "difference", - "micromolar", - "single", - "engineered", - "residues", + "nonpolar", + "improved", "hyperplasia", - "two", - "polar", - "rotameric", - "binding", - "protein", - "bound", "backbone", - "development", - "end", + "states", + "near", + "range", + "failure", + "designed", + "constrain", + "models", + "calculations", + "revealed", + "one", + "biomarker", + "first", + "hydroxyl", + "structure", + "function", + "hormone", + "exacerbated", + "cost", + "considerable", + "inaccuracies", + "underestimation", + "alter", + "trace", + "difference", + "desolvating", + "sensors", + "limitations", "arises", - "within", - "computational", - "pocket", - "relative", - "appearing", - "discrepancy", - "sources", - "mutagenesis" + "designs", + "second", + "containing", + "generate", + "adrenal" ], "release_date":"2017-03-01", "publication":"\"Sampling and energy evaluation challenges in ligand binding protein design\", Protein Sci., 26, 2426-2437", @@ -165081,10 +165491,6 @@ } ], "seq_thr_sim_natural":[ - { - "sim":251.0, - "partner":"2z77" - }, { "sim":251.0, "partner":"2z7a" @@ -165096,6 +165502,10 @@ { "sim":251.0, "partner":"2z76" + }, + { + "sim":251.0, + "partner":"2z77" } ], "struct_thr_sim_designed":[ @@ -165113,7 +165523,7 @@ }, "seq_max_sim_natural":{ "sim":251.0, - "partner":"2z77" + "partner":"2z7a" }, "struct_max_sim_designed":{ "sim":0.9574000239, @@ -165213,90 +165623,90 @@ "rosetta" ], "keywords":[ - "peripheral", "largely", - "concentric", - "confer", + "dimers", + "hydrophobic", + "structural", + "core", "results", - "specificity", - "use", - "bonds", - "modes", - "crystallography", - "including", - "broad", - "irregular", - "determined", - "generally", - "confirms", - "interactions", - "synthetic", - "designing", - "diversity", + "new", + "supercoiled", + "protein", + "topologies", "networks", - "even", - "interaction", + "extensive", "general", - "proteins", - "models", - "dna", - "enables", - "tetramers", - "rings", - "square", - "seen", + "demonstrate", + "two", + "confer", "triangular", - "nature", - "ability", - "differently", - "structures", - "arrays", - "buried", - "atomic", - "particular", - "biology", - "extensive", + "applications", + "helices", + "encoded", + "enables", + "specificity", "nearly", - "hydrogen", + "overall", + "dna", + "modes", "discovered", - "previously", - "programming", - "supercoiled", - "topologies", + "helix", + "polar", "trimers", - "complemented", - "observed", - "design", - "core", - "applications", - "hydrophobic", - "describe", - "encoded", - "tremendous", + "buried", + "fundamentally", + "approach", + "proteins", "packing", - "structural", - "range", + "generally", "accuracy", + "confirms", + "broad", + "use", + "modular", + "tetramers", + "hydrogen", + "square", "double", - "demonstrate", + "including", + "concentric", + "designing", + "design", + "atomic", + "peripheral", + "even", + "biology", "consisting", - "overall", - "helices", - "approach", + "bonds", + "diversity", + "seen", "wide", - "modular", - "two", - "dimers", - "polar", - "central", - "protein", + "complemented", + "interaction", + "ability", "identical", - "helix", - "arises", - "fundamentally", + "whereas", + "describe", + "range", + "central", + "particular", + "models", + "tremendous", + "differently", "vivo", - "new", - "whereas" + "observed", + "structures", + "previously", + "synthetic", + "determined", + "irregular", + "crystallography", + "interactions", + "nature", + "programming", + "arrays", + "rings", + "arises" ], "release_date":"2016-05-25", "publication":"\"De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity\", Science, 352, 680-687", @@ -165457,90 +165867,90 @@ "rosetta" ], "keywords":[ - "peripheral", "largely", - "concentric", - "confer", + "dimers", + "hydrophobic", + "structural", + "core", "results", - "specificity", - "use", - "bonds", - "modes", - "crystallography", - "including", - "broad", - "irregular", - "determined", - "generally", - "confirms", - "interactions", - "synthetic", - "designing", - "diversity", + "new", + "supercoiled", + "protein", + "topologies", "networks", - "even", - "interaction", + "extensive", "general", - "proteins", - "models", - "dna", - "enables", - "tetramers", - "rings", - "square", - "seen", + "demonstrate", + "two", + "confer", "triangular", - "nature", - "ability", - "differently", - "structures", - "arrays", - "buried", - "atomic", - "particular", - "biology", - "extensive", + "applications", + "helices", + "encoded", + "enables", + "specificity", "nearly", - "hydrogen", + "overall", + "dna", + "modes", "discovered", - "previously", - "programming", - "supercoiled", - "topologies", + "helix", + "polar", "trimers", - "complemented", - "observed", - "design", - "core", - "applications", - "hydrophobic", - "describe", - "encoded", - "tremendous", + "buried", + "fundamentally", + "approach", + "proteins", "packing", - "structural", - "range", + "generally", "accuracy", + "confirms", + "broad", + "use", + "modular", + "tetramers", + "hydrogen", + "square", "double", - "demonstrate", + "including", + "concentric", + "designing", + "design", + "atomic", + "peripheral", + "even", + "biology", "consisting", - "overall", - "helices", - "approach", + "bonds", + "diversity", + "seen", "wide", - "modular", - "two", - "dimers", - "polar", - "central", - "protein", + "complemented", + "interaction", + "ability", "identical", - "helix", - "arises", - "fundamentally", + "whereas", + "describe", + "range", + "central", + "particular", + "models", + "tremendous", + "differently", "vivo", - "new", - "whereas" + "observed", + "structures", + "previously", + "synthetic", + "determined", + "irregular", + "crystallography", + "interactions", + "nature", + "programming", + "arrays", + "rings", + "arises" ], "release_date":"2016-05-25", "publication":"\"De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity\", Science, 352, 680-687", @@ -165573,11 +165983,11 @@ "seq_thr_sim_designed":[ { "sim":107.0, - "partner":"6n9h" + "partner":"6naf" }, { "sim":107.0, - "partner":"6naf" + "partner":"6n9h" }, { "sim":101.0, @@ -165634,7 +166044,7 @@ ], "seq_max_sim_designed":{ "sim":107.0, - "partner":"6n9h" + "partner":"6naf" }, "seq_max_sim_natural":[ @@ -165737,90 +166147,90 @@ "rosetta" ], "keywords":[ - "peripheral", "largely", - "concentric", - "confer", + "dimers", + "hydrophobic", + "structural", + "core", "results", - "specificity", - "use", - "bonds", - "modes", - "crystallography", - "including", - "broad", - "irregular", - "determined", - "generally", - "confirms", - "interactions", - "synthetic", - "designing", - "diversity", + "new", + "supercoiled", + "protein", + "topologies", "networks", - "even", - "interaction", + "extensive", "general", - "proteins", - "models", - "dna", - "enables", - "tetramers", - "rings", - "square", - "seen", + "demonstrate", + "two", + "confer", "triangular", - "nature", - "ability", - "differently", - "structures", - "arrays", - "buried", - "atomic", - "particular", - "biology", - "extensive", + "applications", + "helices", + "encoded", + "enables", + "specificity", "nearly", - "hydrogen", + "overall", + "dna", + "modes", "discovered", - "previously", - "programming", - "supercoiled", - "topologies", + "helix", + "polar", "trimers", - "complemented", - "observed", - "design", - "core", - "applications", - "hydrophobic", - "describe", - "encoded", - "tremendous", + "buried", + "fundamentally", + "approach", + "proteins", "packing", - "structural", - "range", + "generally", "accuracy", + "confirms", + "broad", + "use", + "modular", + "tetramers", + "hydrogen", + "square", "double", - "demonstrate", + "including", + "concentric", + "designing", + "design", + "atomic", + "peripheral", + "even", + "biology", "consisting", - "overall", - "helices", - "approach", + "bonds", + "diversity", + "seen", "wide", - "modular", - "two", - "dimers", - "polar", - "central", - "protein", + "complemented", + "interaction", + "ability", "identical", - "helix", - "arises", - "fundamentally", + "whereas", + "describe", + "range", + "central", + "particular", + "models", + "tremendous", + "differently", "vivo", - "new", - "whereas" + "observed", + "structures", + "previously", + "synthetic", + "determined", + "irregular", + "crystallography", + "interactions", + "nature", + "programming", + "arrays", + "rings", + "arises" ], "release_date":"2016-05-25", "publication":"\"De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity\", Science, 352, 680-687", @@ -165857,11 +166267,11 @@ }, { "sim":67.0, - "partner":"6n9h" + "partner":"6naf" }, { "sim":67.0, - "partner":"6naf" + "partner":"6n9h" }, { "sim":66.0, @@ -166002,90 +166412,90 @@ "rosetta" ], "keywords":[ - "peripheral", "largely", - "concentric", - "confer", + "dimers", + "hydrophobic", + "structural", + "core", "results", - "specificity", - "use", - "bonds", - "modes", - "crystallography", - "including", - "broad", - "irregular", - "determined", - "generally", - "confirms", - "interactions", - "synthetic", - "designing", - "diversity", + "new", + "supercoiled", + "protein", + "topologies", "networks", - "even", - "interaction", + "extensive", "general", - "proteins", - "models", - "dna", - "enables", - "tetramers", - "rings", - "square", - "seen", + "demonstrate", + "two", + "confer", "triangular", - "nature", - "ability", - "differently", - "structures", - "arrays", - "buried", - "atomic", - "particular", - "biology", - "extensive", + "applications", + "helices", + "encoded", + "enables", + "specificity", "nearly", - "hydrogen", + "overall", + "dna", + "modes", "discovered", - "previously", - "programming", - "supercoiled", - "topologies", + "helix", + "polar", "trimers", - "complemented", - "observed", - "design", - "core", - "applications", - "hydrophobic", - "describe", - "encoded", - "tremendous", + "buried", + "fundamentally", + "approach", + "proteins", "packing", - "structural", - "range", + "generally", "accuracy", + "confirms", + "broad", + "use", + "modular", + "tetramers", + "hydrogen", + "square", "double", - "demonstrate", + "including", + "concentric", + "designing", + "design", + "atomic", + "peripheral", + "even", + "biology", "consisting", - "overall", - "helices", - "approach", + "bonds", + "diversity", + "seen", "wide", - "modular", - "two", - "dimers", - "polar", - "central", - "protein", + "complemented", + "interaction", + "ability", "identical", - "helix", - "arises", - "fundamentally", + "whereas", + "describe", + "range", + "central", + "particular", + "models", + "tremendous", + "differently", "vivo", - "new", - "whereas" + "observed", + "structures", + "previously", + "synthetic", + "determined", + "irregular", + "crystallography", + "interactions", + "nature", + "programming", + "arrays", + "rings", + "arises" ], "release_date":"2016-05-25", "publication":"\"De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity\", Science, 352, 680-687", @@ -166270,90 +166680,90 @@ "rosetta" ], "keywords":[ - "peripheral", "largely", - "concentric", - "confer", + "dimers", + "hydrophobic", + "structural", + "core", "results", - "specificity", - "use", - "bonds", - "modes", - "crystallography", - "including", - "broad", - "irregular", - "determined", - "generally", - "confirms", - "interactions", - "synthetic", - "designing", - "diversity", + "new", + "supercoiled", + "protein", + "topologies", "networks", - "even", - "interaction", + "extensive", "general", - "proteins", - "models", - "dna", - "enables", - "tetramers", - "rings", - "square", - "seen", + "demonstrate", + "two", + "confer", "triangular", - "nature", - "ability", - "differently", - "structures", - "arrays", - "buried", - "atomic", - "particular", - "biology", - "extensive", + "applications", + "helices", + "encoded", + "enables", + "specificity", "nearly", - "hydrogen", + "overall", + "dna", + "modes", "discovered", - "previously", - "programming", - "supercoiled", - "topologies", + "helix", + "polar", "trimers", - "complemented", - "observed", - "design", - "core", - "applications", - "hydrophobic", - "describe", - "encoded", - "tremendous", + "buried", + "fundamentally", + "approach", + "proteins", "packing", - "structural", - "range", + "generally", "accuracy", + "confirms", + "broad", + "use", + "modular", + "tetramers", + "hydrogen", + "square", "double", - "demonstrate", + "including", + "concentric", + "designing", + "design", + "atomic", + "peripheral", + "even", + "biology", "consisting", - "overall", - "helices", - "approach", + "bonds", + "diversity", + "seen", "wide", - "modular", - "two", - "dimers", - "polar", - "central", - "protein", + "complemented", + "interaction", + "ability", "identical", - "helix", - "arises", - "fundamentally", + "whereas", + "describe", + "range", + "central", + "particular", + "models", + "tremendous", + "differently", "vivo", - "new", - "whereas" + "observed", + "structures", + "previously", + "synthetic", + "determined", + "irregular", + "crystallography", + "interactions", + "nature", + "programming", + "arrays", + "rings", + "arises" ], "release_date":"2016-05-25", "publication":"\"De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity\", Science, 352, 680-687", @@ -166526,90 +166936,90 @@ "rosetta" ], "keywords":[ - "peripheral", "largely", - "concentric", - "confer", + "dimers", + "hydrophobic", + "structural", + "core", "results", - "specificity", - "use", - "bonds", - "modes", - "crystallography", - "including", - "broad", - "irregular", - "determined", - "generally", - "confirms", - "interactions", - "synthetic", - "designing", - "diversity", + "new", + "supercoiled", + "protein", + "topologies", "networks", - "even", - "interaction", + "extensive", "general", - "proteins", - "models", - "dna", - "enables", - "tetramers", - "rings", - "square", - "seen", + "demonstrate", + "two", + "confer", "triangular", - "nature", - "ability", - "differently", - "structures", - "arrays", - "buried", - "atomic", - "particular", - "biology", - "extensive", + "applications", + "helices", + "encoded", + "enables", + "specificity", "nearly", - "hydrogen", + "overall", + "dna", + "modes", "discovered", - "previously", - "programming", - "supercoiled", - "topologies", + "helix", + "polar", "trimers", - "complemented", - "observed", - "design", - "core", - "applications", - "hydrophobic", - "describe", - "encoded", - "tremendous", + "buried", + "fundamentally", + "approach", + "proteins", "packing", - "structural", - "range", + "generally", "accuracy", + "confirms", + "broad", + "use", + "modular", + "tetramers", + "hydrogen", + "square", "double", - "demonstrate", + "including", + "concentric", + "designing", + "design", + "atomic", + "peripheral", + "even", + "biology", "consisting", - "overall", - "helices", - "approach", + "bonds", + "diversity", + "seen", "wide", - "modular", - "two", - "dimers", - "polar", - "central", - "protein", + "complemented", + "interaction", + "ability", "identical", - "helix", - "arises", - "fundamentally", + "whereas", + "describe", + "range", + "central", + "particular", + "models", + "tremendous", + "differently", "vivo", - "new", - "whereas" + "observed", + "structures", + "previously", + "synthetic", + "determined", + "irregular", + "crystallography", + "interactions", + "nature", + "programming", + "arrays", + "rings", + "arises" ], "release_date":"2016-07-06", "publication":"\"De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity\", Science, 352, 680-687", @@ -166754,95 +167164,95 @@ ], "subtitle":"De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity", "tags":[ - "rostta", "de novo protein", + "rostta", "de novo design" ], "keywords":[ - "peripheral", "largely", - "concentric", - "confer", + "dimers", + "hydrophobic", + "structural", + "core", "results", - "specificity", - "use", - "bonds", - "modes", - "crystallography", - "including", - "broad", - "irregular", - "determined", - "generally", - "confirms", - "interactions", - "synthetic", - "designing", - "diversity", + "new", + "supercoiled", + "protein", + "topologies", "networks", - "even", - "interaction", + "extensive", "general", - "proteins", - "models", - "dna", - "enables", - "tetramers", - "rings", - "square", - "seen", + "demonstrate", + "two", + "confer", "triangular", - "nature", - "ability", - "differently", - "structures", - "arrays", - "buried", - "atomic", - "particular", - "biology", - "extensive", + "applications", + "helices", + "encoded", + "enables", + "specificity", "nearly", - "hydrogen", + "overall", + "dna", + "modes", "discovered", - "previously", - "programming", - "supercoiled", - "topologies", + "helix", + "polar", "trimers", - "complemented", - "observed", - "design", - "core", - "applications", - "hydrophobic", - "describe", - "encoded", - "tremendous", + "buried", + "fundamentally", + "approach", + "proteins", "packing", - "structural", - "range", + "generally", "accuracy", + "confirms", + "broad", + "use", + "modular", + "tetramers", + "hydrogen", + "square", "double", - "demonstrate", + "including", + "concentric", + "designing", + "design", + "atomic", + "peripheral", + "even", + "biology", "consisting", - "overall", - "helices", - "approach", + "bonds", + "diversity", + "seen", "wide", - "modular", - "two", - "dimers", - "polar", - "central", - "protein", + "complemented", + "interaction", + "ability", "identical", - "helix", - "arises", - "fundamentally", + "whereas", + "describe", + "range", + "central", + "particular", + "models", + "tremendous", + "differently", "vivo", - "new", - "whereas" + "observed", + "structures", + "previously", + "synthetic", + "determined", + "irregular", + "crystallography", + "interactions", + "nature", + "programming", + "arrays", + "rings", + "arises" ], "release_date":"2016-05-25", "publication":"\"De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity\", Science, 352, 680-687", @@ -166995,90 +167405,90 @@ "rosetta" ], "keywords":[ - "peripheral", "largely", - "concentric", - "confer", + "dimers", + "hydrophobic", + "structural", + "core", "results", - "specificity", - "use", - "bonds", - "modes", - "crystallography", - "including", - "broad", - "irregular", - "determined", - "generally", - "confirms", - "interactions", - "synthetic", - "designing", - "diversity", + "new", + "supercoiled", + "protein", + "topologies", "networks", - "even", - "interaction", + "extensive", "general", - "proteins", - "models", - "dna", - "enables", - "tetramers", - "rings", - "square", - "seen", + "demonstrate", + "two", + "confer", "triangular", - "nature", - "ability", - "differently", - "structures", - "arrays", - "buried", - "atomic", - "particular", - "biology", - "extensive", + "applications", + "helices", + "encoded", + "enables", + "specificity", "nearly", - "hydrogen", + "overall", + "dna", + "modes", "discovered", - "previously", - "programming", - "supercoiled", - "topologies", + "helix", + "polar", "trimers", - "complemented", - "observed", - "design", - "core", - "applications", - "hydrophobic", - "describe", - "encoded", - "tremendous", + "buried", + "fundamentally", + "approach", + "proteins", "packing", - "structural", - "range", + "generally", "accuracy", + "confirms", + "broad", + "use", + "modular", + "tetramers", + "hydrogen", + "square", "double", - "demonstrate", + "including", + "concentric", + "designing", + "design", + "atomic", + "peripheral", + "even", + "biology", "consisting", - "overall", - "helices", - "approach", + "bonds", + "diversity", + "seen", "wide", - "modular", - "two", - "dimers", - "polar", - "central", - "protein", + "complemented", + "interaction", + "ability", "identical", - "helix", - "arises", - "fundamentally", + "whereas", + "describe", + "range", + "central", + "particular", + "models", + "tremendous", + "differently", "vivo", - "new", - "whereas" + "observed", + "structures", + "previously", + "synthetic", + "determined", + "irregular", + "crystallography", + "interactions", + "nature", + "programming", + "arrays", + "rings", + "arises" ], "release_date":"2016-05-25", "publication":"\"De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity\", Science, 352, 680-687", @@ -167225,90 +167635,90 @@ "rosetta" ], "keywords":[ - "peripheral", "largely", - "concentric", - "confer", + "dimers", + "hydrophobic", + "structural", + "core", "results", - "specificity", - "use", - "bonds", - "modes", - "crystallography", - "including", - "broad", - "irregular", - "determined", - "generally", - "confirms", - "interactions", - "synthetic", - "designing", - "diversity", + "new", + "supercoiled", + "protein", + "topologies", "networks", - "even", - "interaction", + "extensive", "general", - "proteins", - "models", - "dna", - "enables", - "tetramers", - "rings", - "square", - "seen", + "demonstrate", + "two", + "confer", "triangular", - "nature", - "ability", - "differently", - "structures", - "arrays", - "buried", - "atomic", - "particular", - "biology", - "extensive", + "applications", + "helices", + "encoded", + "enables", + "specificity", "nearly", - "hydrogen", + "overall", + "dna", + "modes", "discovered", - "previously", - "programming", - "supercoiled", - "topologies", + "helix", + "polar", "trimers", - "complemented", - "observed", - "design", - "core", - "applications", - "hydrophobic", - "describe", - "encoded", - "tremendous", + "buried", + "fundamentally", + "approach", + "proteins", "packing", - "structural", - "range", + "generally", "accuracy", + "confirms", + "broad", + "use", + "modular", + "tetramers", + "hydrogen", + "square", "double", - "demonstrate", + "including", + "concentric", + "designing", + "design", + "atomic", + "peripheral", + "even", + "biology", "consisting", - "overall", - "helices", - "approach", + "bonds", + "diversity", + "seen", "wide", - "modular", - "two", - "dimers", - "polar", - "central", - "protein", + "complemented", + "interaction", + "ability", "identical", - "helix", - "arises", - "fundamentally", + "whereas", + "describe", + "range", + "central", + "particular", + "models", + "tremendous", + "differently", "vivo", - "new", - "whereas" + "observed", + "structures", + "previously", + "synthetic", + "determined", + "irregular", + "crystallography", + "interactions", + "nature", + "programming", + "arrays", + "rings", + "arises" ], "release_date":"2016-05-25", "publication":"\"De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity\", Science, 352, 680-687", @@ -167440,121 +167850,121 @@ ], "subtitle":"Computationally designed thioredoxin df106", "tags":[ - "thioredoxin", - "rosetta", "computational design", "de novo protein", - "oxidoreductase" + "rosetta", + "oxidoreductase", + "thioredoxin" ], "keywords":[ - "monomeric", - "improve", - "thus", + "templates", + "escherichia", + "rate", + "adopt", + "structural", + "development", + "methods", + "experimental", "multiple", + "conducted", + "three", "details", + "resemblance", + "protein", + "study", + "six", "close", - "still", - "generated", - "authentic", + "two", "purified", - "experimentally", - "120", "crystal", - "methods", - "determined", - "target", - "based", - "sequences", - "order", - "8", - "adopt", - "similarity", - "structure", - "escherichia", - "predict", - "able", - "realize", - "conformations", - "recommend", - "proteins", - "solved", - "program", - "produce", - "tools", - "influence", - "criteria", - "remains", - "used", - "rigid", - "3", - "ability", - "furthermore", - "structures", - "recreate", - "templates", - "three", - "conducted", - "shows", - "investigate", + "stable", + "authentic", + "care", + "prior", "special", - "powerful", - "32", + "using", + "improve", + "program", "taken", - "sufficiently", - "synthesize", - "coli", - "geometry", - "resulted", - "template", - "among", - "1", - "method", - "challenging", + "shows", + "conformational", "limits", - "six", - "rate", - "design", - "task", - "progressive", + "able", "soluble", - "using", - "high", - "structural", + "synthesize", + "influence", + "experimentally", + "furthermore", "selected", - "optimizing", - "capabilities", - "designs", - "despite", + "thus", + "rigid", + "progressive", + "thioredoxin", + "20", + "proteins", + "criteria", "eight", - "one", - "conformational", - "chose", - "difference", - "revealing", - "prior", - "study", - "focusing", - "stable", + "2", "success", - "thioredoxin", + "predict", + "focusing", + "found", + "realize", + "sufficiently", + "computational", + "recreate", + "tools", + "1", + "investigate", + "task", + "design", + "challenging", + "used", + "produce", + "still", "rosetta", - "experimental", "fold", - "care", - "resemblance", - "found", - "two", - "evaluation", - "objective", - "significant", - "protein", - "yield", - "2", - "development", + "revealing", + "template", + "resulted", + "ability", + "coli", + "solved", + "capabilities", "evaluated", - "computational", + "method", + "recommend", + "order", + "sequences", + "chose", + "one", + "evaluation", + "geometry", + "structures", + "3", "48", - "20" + "based", + "remains", + "structure", + "monomeric", + "optimizing", + "among", + "determined", + "powerful", + "target", + "120", + "yield", + "objective", + "high", + "difference", + "generated", + "conformations", + "despite", + "32", + "designs", + "similarity", + "8", + "significant" ], "release_date":"2016-10-05", "publication":"\"Computational Redesign of Thioredoxin Is Hypersensitive toward Minor Conformational Changes in the Backbone Template\", J.Mol.Biol., 428, 4361-4377", @@ -167703,10 +168113,6 @@ "sim":58.0, "partner":"2h75" }, - { - "sim":57.0, - "partner":"1tk5" - }, { "sim":57.0, "partner":"1sl0" @@ -167789,15 +168195,15 @@ }, { "sim":57.0, - "partner":"1f6m" + "partner":"1keb" }, { "sim":57.0, - "partner":"1keb" + "partner":"1tkd" }, { "sim":57.0, - "partner":"1tkd" + "partner":"1f6m" }, { "sim":57.0, @@ -167811,6 +168217,10 @@ "sim":57.0, "partner":"1t8e" }, + { + "sim":57.0, + "partner":"1tk5" + }, { "sim":57.0, "partner":"5e4w" @@ -168104,81 +168514,81 @@ "subtitle":"Crystal structure of the de novo mini protein gehee_06", "tags":[ "de novo design of hyper stable", - "disulfide-rich", - "de novo protein" + "de novo protein", + "disulfide-rich" ], "keywords":[ - "stability", - "covalent", - "thermal", - "combining", + "tertiary", + "12", + "models", "generation", - "excellent", - "tissue", + "naturally", + "design", + "constrained", "specified", - "models", - "restricted", - "larger", "specificity", - "use", - "chemical", - "presented", + "development", + "fit", + "methods", + "active", + "nearly", + "therapeutics", + "structures", "de", - "novo", - "stable", - "drugs", + "experimentally", + "combining", "encodable", + "conformationally", + "exceptionally", + "properties", "scaffolds", - "accurate", "pharmacologically", - "peptides", - "enable", - "would", - "subset", - "active", - "shapes", - "provide", - "precisely", - "methods", - "experimentally", - "heterochiral", - "occurring", - "constrained", - "ability", - "crosslinks", - "generally", + "targets", "determined", - "much", - "12", - "design", + "provide", + "residue", "new", + "precisely", + "subset", + "thermal", + "covalent", + "nmr", + "protein", "denaturation", + "inhibitors", "basis", - "therapeutics", - "naturally", - "protein", - "structures", - "residue", - "genetically", - "targets", - "exceptionally", - "pharmaceutical", + "crosslinks", "pockets", - "nmr", - "development", - "describe", - "tertiary", + "stability", + "tissue", + "accurate", + "would", + "generally", + "binding", + "pharmaceutical", + "genetically", + "enable", + "use", + "presented", + "ability", + "shapes", + "novo", + "much", + "heterochiral", + "peptides", + "excellent", + "drugs", + "larger", "identical", - "conformationally", - "arbitrary", - "fit", "penetration", + "chemical", + "arbitrary", + "stable", + "describe", + "restricted", "evolved", - "inhibitors", "computational", - "nearly", - "binding", - "properties" + "occurring" ], "release_date":"2016-09-28", "publication":"\"Accurate de novo design of hyperstable constrained peptides\", Nature, 538, 329-335", @@ -168374,77 +168784,77 @@ "de novo protein" ], "keywords":[ - "stability", - "covalent", - "thermal", - "combining", + "tertiary", + "12", + "models", "generation", - "excellent", - "tissue", + "naturally", + "design", + "constrained", "specified", - "models", - "restricted", - "larger", "specificity", - "use", - "chemical", - "presented", + "development", + "fit", + "methods", + "active", + "nearly", + "therapeutics", + "structures", "de", - "novo", - "stable", - "drugs", + "experimentally", + "combining", "encodable", + "conformationally", + "exceptionally", + "properties", "scaffolds", - "accurate", "pharmacologically", - "peptides", - "enable", - "would", - "subset", - "active", - "shapes", - "provide", - "precisely", - "methods", - "experimentally", - "heterochiral", - "occurring", - "constrained", - "ability", - "crosslinks", - "generally", + "targets", "determined", - "much", - "12", - "design", + "provide", + "residue", "new", + "precisely", + "subset", + "thermal", + "covalent", + "nmr", + "protein", "denaturation", + "inhibitors", "basis", - "therapeutics", - "naturally", - "protein", - "structures", - "residue", - "genetically", - "targets", - "exceptionally", - "pharmaceutical", + "crosslinks", "pockets", - "nmr", - "development", - "describe", - "tertiary", + "stability", + "tissue", + "accurate", + "would", + "generally", + "binding", + "pharmaceutical", + "genetically", + "enable", + "use", + "presented", + "ability", + "shapes", + "novo", + "much", + "heterochiral", + "peptides", + "excellent", + "drugs", + "larger", "identical", - "conformationally", - "arbitrary", - "fit", "penetration", + "chemical", + "arbitrary", + "stable", + "describe", + "restricted", "evolved", - "inhibitors", "computational", - "nearly", - "binding", - "properties" + "occurring" ], "release_date":"2016-09-28", "publication":"\"Accurate de novo design of hyperstable constrained peptides\", Nature, 538, 329-335", @@ -168637,83 +169047,83 @@ ], "subtitle":"Solution structure of the de novo mini protein geehe_02", "tags":[ - "disulfide-rich", - "peptide design", "de novo protein", - "drug design" + "drug design", + "peptide design", + "disulfide-rich" ], "keywords":[ - "stability", - "covalent", - "thermal", - "combining", + "tertiary", + "12", + "models", "generation", - "excellent", - "tissue", + "naturally", + "design", + "constrained", "specified", - "models", - "restricted", - "larger", "specificity", - "use", - "chemical", - "presented", + "development", + "fit", + "methods", + "active", + "nearly", + "therapeutics", + "structures", "de", - "novo", - "stable", - "drugs", + "experimentally", + "combining", "encodable", + "conformationally", + "exceptionally", + "properties", "scaffolds", - "accurate", "pharmacologically", - "peptides", - "enable", - "would", - "subset", - "active", - "shapes", - "provide", - "precisely", - "methods", - "experimentally", - "heterochiral", - "occurring", - "constrained", - "ability", - "crosslinks", - "generally", + "targets", "determined", - "much", - "12", - "design", + "provide", + "residue", "new", + "precisely", + "subset", + "thermal", + "covalent", + "nmr", + "protein", "denaturation", + "inhibitors", "basis", - "therapeutics", - "naturally", - "protein", - "structures", - "residue", - "genetically", - "targets", - "exceptionally", - "pharmaceutical", + "crosslinks", "pockets", - "nmr", - "development", - "describe", - "tertiary", + "stability", + "tissue", + "accurate", + "would", + "generally", + "binding", + "pharmaceutical", + "genetically", + "enable", + "use", + "presented", + "ability", + "shapes", + "novo", + "much", + "heterochiral", + "peptides", + "excellent", + "drugs", + "larger", "identical", - "conformationally", - "arbitrary", - "fit", "penetration", + "chemical", + "arbitrary", + "stable", + "describe", + "restricted", "evolved", - "inhibitors", "computational", - "nearly", - "binding", - "properties" + "occurring" ], "release_date":"2016-09-28", "publication":"\"Accurate de novo design of hyperstable constrained peptides\", Nature, 538, 329-335", @@ -168854,95 +169264,95 @@ ], "subtitle":"Designed two-ring homotetramer at 3.8a resolution", "tags":[ - "hydrogen bond networks", "de novo protein", - "protein design" + "protein design", + "hydrogen bond networks" ], "keywords":[ - "peripheral", "largely", - "concentric", - "confer", + "dimers", + "hydrophobic", + "structural", + "core", "results", - "specificity", - "use", - "bonds", - "modes", - "crystallography", - "including", - "broad", - "irregular", - "determined", - "generally", - "confirms", - "interactions", - "synthetic", - "designing", - "diversity", + "new", + "supercoiled", + "protein", + "topologies", "networks", - "even", - "interaction", + "extensive", "general", - "proteins", - "models", - "dna", - "enables", - "tetramers", - "rings", - "square", - "seen", + "demonstrate", + "two", + "confer", "triangular", - "nature", - "ability", - "differently", - "structures", - "arrays", - "buried", - "atomic", - "particular", - "biology", - "extensive", + "applications", + "helices", + "encoded", + "enables", + "specificity", "nearly", - "hydrogen", + "overall", + "dna", + "modes", "discovered", - "previously", - "programming", - "supercoiled", - "topologies", + "helix", + "polar", "trimers", - "complemented", - "observed", - "design", - "core", - "applications", - "hydrophobic", - "describe", - "encoded", - "tremendous", + "buried", + "fundamentally", + "approach", + "proteins", "packing", - "structural", - "range", + "generally", "accuracy", + "confirms", + "broad", + "use", + "modular", + "tetramers", + "hydrogen", + "square", "double", - "demonstrate", + "including", + "concentric", + "designing", + "design", + "atomic", + "peripheral", + "even", + "biology", "consisting", - "overall", - "helices", - "approach", + "bonds", + "diversity", + "seen", "wide", - "modular", - "two", - "dimers", - "polar", - "central", - "protein", + "complemented", + "interaction", + "ability", "identical", - "helix", - "arises", - "fundamentally", + "whereas", + "describe", + "range", + "central", + "particular", + "models", + "tremendous", + "differently", "vivo", - "new", - "whereas" + "observed", + "structures", + "previously", + "synthetic", + "determined", + "irregular", + "crystallography", + "interactions", + "nature", + "programming", + "arrays", + "rings", + "arises" ], "release_date":"2016-06-29", "publication":"\"De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity\", Science, 352, 680-687", @@ -169084,84 +169494,84 @@ "rosetta" ], "keywords":[ - "cyclically", - "use", + "probe", + "repeat", "complexes", - "scattering", - "close", "idealized", "roles", - "experimentally", - "crystal", - "probe", + "newly", "assess", - "repeat", - "monomer", - "consistent", - "cyclic", - "direct", - "interfaces", + "new", + "model", + "protein", + "homotetramers", + "six", + "rapid", + "close", + "cyclically", "general", - "proteins", - "models", + "crystal", + "stable", + "corresponding", + "monodisperse", "play", - "designability", "characterized", + "formed", + "enumeration", + "experimentally", + "biological", + "consistent", + "cyclic", + "approach", + "proteins", + "use", + "scattering", "interface", - "ability", - "onto", - "structures", - "21", - "solution", - "corresponding", - "function", - "assembly", - "biology", - "form", - "rapid", - "data", - "obtained", - "newly", - "sufficiently", - "generate", - "report", + "found", + "15", + "monomer", "four", - "method", - "approaches", - "six", - "design", - "model", - "followed", - "96", + "sufficiently", + "computational", + "obtained", + "direct", "symmetry", + "design", + "onto", + "biology", + "assembly", + "designability", + "employs", + "solution", + "ability", "sequence", - "biological", "homotrimers", + "docked", + "96", + "method", "could", + "form", + "models", + "interfaces", + "custom", + "one", + "structures", + "approaches", + "21", "important", - "employs", + "possess", + "report", + "followed", + "function", + "homodimers", "homopentamer", - "designs", - "one", - "monodisperse", - "approach", - "stable", + "systematic", "enable", - "custom", - "found", + "data", "arrangements", - "systematic", - "protein", - "enumeration", - "possess", - "15", - "homodimers", - "docked", - "computational", - "homotetramers", - "formed", - "five", - "new" + "designs", + "generate", + "five" ], "release_date":"2017-04-12", "publication":"\"Computational design of self-assembling cyclic protein homo-oligomers\", Nat Chem, 9, 353-360", @@ -169194,11 +169604,11 @@ "seq_thr_sim_designed":[ { "sim":472.0, - "partner":"6vfh" + "partner":"6vfk" }, { "sim":472.0, - "partner":"6vfk" + "partner":"6vfh" } ], "seq_thr_sim_natural":[ @@ -169212,7 +169622,7 @@ ], "seq_max_sim_designed":{ "sim":472.0, - "partner":"6vfh" + "partner":"6vfk" }, "seq_max_sim_natural":[ @@ -169274,82 +169684,82 @@ "de novo designed peptide" ], "keywords":[ - "sites", - "containing", - "coiled", - "toward", + "designed", "3scc", - "allows", - "importance", + "conformation", + "often", "molecular", - "cysteine", + "recognition", + "unavailable", + "s3", + "metal", "one", - "change", - "proteins", - "trigonal", - "use", - "complexation", "geometry", - "evaluate", - "pyramidal", - "study", - "reorientation", - "metal", + "show", + "planar", + "preferred", + "structures", + "3sccs", + "oriented", + "concepts", "predisposition", - "assessment", + "trigonal", + "requiring", + "core", + "pyramidal", + "species", + "allows", + "important", + "selective", + "fold", + "thiol", + "cysteine", + "ligands", "metalloregulatory", "pb", - "fold", - "human", "preorganization", - "designed", - "preferred", - "species", - "hg", - "iii", - "degree", - "recognition", - "endo", - "3sccs", - "cys", + "protein", "nature", + "complexation", + "study", + "s3o", + "reorientation", "selectivity", - "requiring", - "rotamers", - "often", - "preorganized", + "cysteines", + "proteins", + "sites", + "binding", + "cys", + "use", + "coiled", + "evaluate", + "degree", + "change", + "upon", + "iii", + "native", + "significant", + "rotation", "retrotransposons", - "obtain", + "dictates", + "rotamers", "ms3", - "show", - "ii", - "selective", - "core", - "oriented", - "rotation", - "significant", - "structures", - "unavailable", - "upon", - "conformation", - "protein", - "achieving", + "preorganized", + "endo", + "toward", + "whereas", "predisposed", + "achieving", "coils", - "s3o", - "zn", "exploited", - "native", - "cysteines", - "ligands", - "dictates", - "s3", - "binding", - "thiol", - "important", - "planar", - "concepts", - "whereas" + "hg", + "assessment", + "human", + "containing", + "zn", + "importance", + "obtain", + "ii" ], "release_date":"2016-08-31", "publication":"\"A Crystallographic Examination of Predisposition versus Preorganization in de Novo Designed Metalloproteins\", J.Am.Chem.Soc., 138, 11979-11988", @@ -169382,11 +169792,11 @@ "seq_thr_sim_designed":[ { "sim":57.0, - "partner":"5u9u" + "partner":"5u9t" }, { "sim":57.0, - "partner":"5u9t" + "partner":"5u9u" }, { "sim":51.0, @@ -169398,27 +169808,27 @@ }, { "sim":51.0, - "partner":"5kb1" + "partner":"7n2y" }, { "sim":51.0, - "partner":"6egl" + "partner":"5kb1" }, { "sim":51.0, - "partner":"7n2y" + "partner":"5kb0" }, { "sim":51.0, - "partner":"5kb0" + "partner":"6egl" }, { "sim":51.0, - "partner":"6egm" + "partner":"7n2z" }, { "sim":51.0, - "partner":"7n2z" + "partner":"6egm" }, { "sim":51.0, @@ -169437,14 +169847,6 @@ "sim":0.9983999729, "partner":"5u9u" }, - { - "sim":1.0, - "partner":"2jgo" - }, - { - "sim":1.0, - "partner":"3ljm" - }, { "sim":0.961499989, "partner":"3h5f" @@ -169454,28 +169856,28 @@ "partner":"3h5g" }, { - "sim":0.991599977, - "partner":"2x6p" + "sim":1.0, + "partner":"2jgo" }, { - "sim":0.9930999875, - "partner":"1cos" + "sim":1.0, + "partner":"3ljm" }, { - "sim":0.9919999838, - "partner":"5uxt" + "sim":0.9930999875, + "partner":"1cos" }, { - "sim":0.9542000294, - "partner":"5kb0" + "sim":0.991599977, + "partner":"2x6p" }, { - "sim":0.9542000294, - "partner":"5kb2" + "sim":0.9919999838, + "partner":"5uxt" }, { - "sim":0.9542000294, - "partner":"6egp" + "sim":0.9559999704, + "partner":"6ego" }, { "sim":0.9926000237, @@ -169485,14 +169887,6 @@ "sim":0.9941999912, "partner":"6q1w" }, - { - "sim":0.9943000078, - "partner":"6v5g" - }, - { - "sim":0.9941999912, - "partner":"6v5i" - }, { "sim":0.9941999912, "partner":"6v5j" @@ -169502,8 +169896,12 @@ "partner":"6u47" }, { - "sim":0.9929000139, - "partner":"6v4y" + "sim":0.9943000078, + "partner":"6v5g" + }, + { + "sim":0.9941999912, + "partner":"6v5i" }, { "sim":0.9901999831, @@ -169522,12 +169920,8 @@ "partner":"6v58" }, { - "sim":0.9542000294, - "partner":"6mcd" - }, - { - "sim":0.9617999792, - "partner":"1coi" + "sim":0.9929000139, + "partner":"6v4y" }, { "sim":0.9521999955, @@ -169537,45 +169931,61 @@ "sim":0.9542000294, "partner":"6os8" }, + { + "sim":0.9527999759, + "partner":"6ovv" + }, { "sim":0.951399982, "partner":"6ovu" }, { - "sim":0.9527999759, - "partner":"6ovv" + "sim":0.9521999955, + "partner":"6ov9" }, { - "sim":0.9524999857, - "partner":"6q22" + "sim":0.9617999792, + "partner":"1coi" }, { - "sim":0.9535999894, - "partner":"1fmh" + "sim":0.9559999704, + "partner":"6q5r" + }, + { + "sim":0.954400003, + "partner":"6q5s" }, { "sim":0.9952999949, "partner":"5vte" }, { - "sim":0.9559999704, - "partner":"6ego" + "sim":0.9527000189, + "partner":"6q5q" }, { - "sim":0.9521999955, - "partner":"6ov9" + "sim":0.9535999894, + "partner":"1fmh" }, { - "sim":0.9559999704, - "partner":"6q5r" + "sim":0.9542000294, + "partner":"5kb0" }, { - "sim":0.954400003, - "partner":"6q5s" + "sim":0.9542000294, + "partner":"5kb2" }, { - "sim":0.9527000189, - "partner":"6q5q" + "sim":0.9542000294, + "partner":"6egp" + }, + { + "sim":0.9542000294, + "partner":"6mcd" + }, + { + "sim":0.9524999857, + "partner":"6q22" } ], "struct_thr_sim_natural":[ @@ -169583,7 +169993,7 @@ ], "seq_max_sim_designed":{ "sim":57.0, - "partner":"5u9u" + "partner":"5u9t" }, "seq_max_sim_natural":[ @@ -169640,86 +170050,86 @@ "subtitle":"Crystal structure of a tris-thiolate pb(ii) complex in a de novo three-stranded coiled coil peptide", "tags":[ "de novo protein", - "de novo designed peptide", - "three-stranded coiled coil tris-thiolate pb(ii) complex in de novo peptide" + "three-stranded coiled coil tris-thiolate pb(ii) complex in de novo peptide", + "de novo designed peptide" ], "keywords":[ - "sites", - "containing", - "coiled", - "toward", + "designed", "3scc", - "allows", - "importance", + "conformation", + "often", "molecular", - "cysteine", + "recognition", + "unavailable", + "s3", + "metal", "one", - "change", - "proteins", - "trigonal", - "use", - "complexation", "geometry", - "evaluate", - "pyramidal", - "study", - "reorientation", - "metal", + "show", + "planar", + "preferred", + "structures", + "3sccs", + "oriented", + "concepts", "predisposition", - "assessment", + "trigonal", + "requiring", + "core", + "pyramidal", + "species", + "allows", + "important", + "selective", + "fold", + "thiol", + "cysteine", + "ligands", "metalloregulatory", "pb", - "fold", - "human", "preorganization", - "designed", - "preferred", - "species", - "hg", - "iii", - "degree", - "recognition", - "endo", - "3sccs", - "cys", + "protein", "nature", + "complexation", + "study", + "s3o", + "reorientation", "selectivity", - "requiring", - "rotamers", - "often", - "preorganized", + "cysteines", + "proteins", + "sites", + "binding", + "cys", + "use", + "coiled", + "evaluate", + "degree", + "change", + "upon", + "iii", + "native", + "significant", + "rotation", "retrotransposons", - "obtain", + "dictates", + "rotamers", "ms3", - "show", - "ii", - "selective", - "core", - "oriented", - "rotation", - "significant", - "structures", - "unavailable", - "upon", - "conformation", - "protein", - "achieving", + "preorganized", + "endo", + "toward", + "whereas", "predisposed", + "achieving", "coils", - "s3o", - "zn", "exploited", - "native", - "cysteines", - "ligands", - "dictates", - "s3", - "binding", - "thiol", - "important", - "planar", - "concepts", - "whereas" + "hg", + "assessment", + "human", + "containing", + "zn", + "importance", + "obtain", + "ii" ], "release_date":"2016-08-31", "publication":"\"A Crystallographic Examination of Predisposition versus Preorganization in de Novo Designed Metalloproteins\", J.Am.Chem.Soc., 138, 11979-11988", @@ -169768,15 +170178,15 @@ }, { "sim":64.0, - "partner":"6ego" + "partner":"7n2y" }, { "sim":64.0, - "partner":"6egp" + "partner":"6ego" }, { "sim":64.0, - "partner":"7n2y" + "partner":"5kb2" }, { "sim":64.0, @@ -169784,7 +170194,7 @@ }, { "sim":64.0, - "partner":"5kb2" + "partner":"6egp" }, { "sim":60.0, @@ -169792,7 +170202,7 @@ }, { "sim":51.0, - "partner":"5u9u" + "partner":"5u9t" }, { "sim":51.0, @@ -169800,7 +170210,7 @@ }, { "sim":51.0, - "partner":"5u9t" + "partner":"5u9u" } ], "seq_thr_sim_natural":[ @@ -169909,87 +170319,87 @@ ], "subtitle":"Crystal structure of a tris-thiolate hg(ii) complex in a de novo three stranded coiled coil peptide", "tags":[ - "three stranded coiled coil tris-thiolate hg(ii) complex in helical coiled coil", "de novo protein", - "de novo designed peptide" + "de novo designed peptide", + "three stranded coiled coil tris-thiolate hg(ii) complex in helical coiled coil" ], "keywords":[ - "sites", - "containing", - "coiled", - "toward", + "designed", "3scc", - "allows", - "importance", + "conformation", + "often", "molecular", - "cysteine", + "recognition", + "unavailable", + "s3", + "metal", "one", - "change", - "proteins", - "trigonal", - "use", - "complexation", "geometry", - "evaluate", - "pyramidal", - "study", - "reorientation", - "metal", + "show", + "planar", + "preferred", + "structures", + "3sccs", + "oriented", + "concepts", "predisposition", - "assessment", + "trigonal", + "requiring", + "core", + "pyramidal", + "species", + "allows", + "important", + "selective", + "fold", + "thiol", + "cysteine", + "ligands", "metalloregulatory", "pb", - "fold", - "human", "preorganization", - "designed", - "preferred", - "species", - "hg", - "iii", - "degree", - "recognition", - "endo", - "3sccs", - "cys", + "protein", "nature", + "complexation", + "study", + "s3o", + "reorientation", "selectivity", - "requiring", - "rotamers", - "often", - "preorganized", + "cysteines", + "proteins", + "sites", + "binding", + "cys", + "use", + "coiled", + "evaluate", + "degree", + "change", + "upon", + "iii", + "native", + "significant", + "rotation", "retrotransposons", - "obtain", + "dictates", + "rotamers", "ms3", - "show", - "ii", - "selective", - "core", - "oriented", - "rotation", - "significant", - "structures", - "unavailable", - "upon", - "conformation", - "protein", - "achieving", + "preorganized", + "endo", + "toward", + "whereas", "predisposed", + "achieving", "coils", - "s3o", - "zn", "exploited", - "native", - "cysteines", - "ligands", - "dictates", - "s3", - "binding", - "thiol", - "important", - "planar", - "concepts", - "whereas" + "hg", + "assessment", + "human", + "containing", + "zn", + "importance", + "obtain", + "ii" ], "release_date":"2016-08-31", "publication":"\"A Crystallographic Examination of Predisposition versus Preorganization in de Novo Designed Metalloproteins\", J.Am.Chem.Soc., 138, 11979-11988", @@ -170038,15 +170448,15 @@ }, { "sim":64.0, - "partner":"6ego" + "partner":"7n2y" }, { "sim":64.0, - "partner":"6egp" + "partner":"6ego" }, { "sim":64.0, - "partner":"7n2y" + "partner":"5kb2" }, { "sim":64.0, @@ -170054,7 +170464,7 @@ }, { "sim":64.0, - "partner":"5kb2" + "partner":"6egp" }, { "sim":60.0, @@ -170062,7 +170472,7 @@ }, { "sim":51.0, - "partner":"5u9u" + "partner":"5u9t" }, { "sim":51.0, @@ -170070,7 +170480,7 @@ }, { "sim":51.0, - "partner":"5u9t" + "partner":"5u9u" } ], "seq_thr_sim_natural":[ @@ -170172,86 +170582,86 @@ "subtitle":"Crystal structure of a tris-thiolate zn(ii)s3o complex in a de novo three-stranded coiled coil peptide", "tags":[ "de novo protein", - "de novo designed peptide", - "three-stranded coiled coil tris-thiolate zn(ii)s3o in de novo helical coiled coil structure" + "three-stranded coiled coil tris-thiolate zn(ii)s3o in de novo helical coiled coil structure", + "de novo designed peptide" ], "keywords":[ - "sites", - "containing", - "coiled", - "toward", + "designed", "3scc", - "allows", - "importance", + "conformation", + "often", "molecular", - "cysteine", + "recognition", + "unavailable", + "s3", + "metal", "one", - "change", - "proteins", - "trigonal", - "use", - "complexation", "geometry", - "evaluate", - "pyramidal", - "study", - "reorientation", - "metal", + "show", + "planar", + "preferred", + "structures", + "3sccs", + "oriented", + "concepts", "predisposition", - "assessment", + "trigonal", + "requiring", + "core", + "pyramidal", + "species", + "allows", + "important", + "selective", + "fold", + "thiol", + "cysteine", + "ligands", "metalloregulatory", "pb", - "fold", - "human", "preorganization", - "designed", - "preferred", - "species", - "hg", - "iii", - "degree", - "recognition", - "endo", - "3sccs", - "cys", + "protein", "nature", + "complexation", + "study", + "s3o", + "reorientation", "selectivity", - "requiring", - "rotamers", - "often", - "preorganized", + "cysteines", + "proteins", + "sites", + "binding", + "cys", + "use", + "coiled", + "evaluate", + "degree", + "change", + "upon", + "iii", + "native", + "significant", + "rotation", "retrotransposons", - "obtain", + "dictates", + "rotamers", "ms3", - "show", - "ii", - "selective", - "core", - "oriented", - "rotation", - "significant", - "structures", - "unavailable", - "upon", - "conformation", - "protein", - "achieving", + "preorganized", + "endo", + "toward", + "whereas", "predisposed", + "achieving", "coils", - "s3o", - "zn", "exploited", - "native", - "cysteines", - "ligands", - "dictates", - "s3", - "binding", - "thiol", - "important", - "planar", - "concepts", - "whereas" + "hg", + "assessment", + "human", + "containing", + "zn", + "importance", + "obtain", + "ii" ], "release_date":"2016-08-31", "publication":"\"A Crystallographic Examination of Predisposition versus Preorganization in de Novo Designed Metalloproteins\", J.Am.Chem.Soc., 138, 11979-11988", @@ -170467,84 +170877,84 @@ "rosetta" ], "keywords":[ - "cyclically", - "use", + "probe", + "repeat", "complexes", - "scattering", - "close", "idealized", "roles", - "experimentally", - "crystal", - "probe", + "newly", "assess", - "repeat", - "monomer", - "consistent", - "cyclic", - "direct", - "interfaces", + "new", + "model", + "protein", + "homotetramers", + "six", + "rapid", + "close", + "cyclically", "general", - "proteins", - "models", + "crystal", + "stable", + "corresponding", + "monodisperse", "play", - "designability", "characterized", + "formed", + "enumeration", + "experimentally", + "biological", + "consistent", + "cyclic", + "approach", + "proteins", + "use", + "scattering", "interface", - "ability", - "onto", - "structures", - "21", - "solution", - "corresponding", - "function", - "assembly", - "biology", - "form", - "rapid", - "data", - "obtained", - "newly", - "sufficiently", - "generate", - "report", + "found", + "15", + "monomer", "four", - "method", - "approaches", - "six", - "design", - "model", - "followed", - "96", + "sufficiently", + "computational", + "obtained", + "direct", "symmetry", + "design", + "onto", + "biology", + "assembly", + "designability", + "employs", + "solution", + "ability", "sequence", - "biological", "homotrimers", + "docked", + "96", + "method", "could", + "form", + "models", + "interfaces", + "custom", + "one", + "structures", + "approaches", + "21", "important", - "employs", + "possess", + "report", + "followed", + "function", + "homodimers", "homopentamer", - "designs", - "one", - "monodisperse", - "approach", - "stable", + "systematic", "enable", - "custom", - "found", + "data", "arrangements", - "systematic", - "protein", - "enumeration", - "possess", - "15", - "homodimers", - "docked", - "computational", - "homotetramers", - "formed", - "five", - "new" + "designs", + "generate", + "five" ], "release_date":"2017-04-12", "publication":"\"Computational design of self-assembling cyclic protein homo-oligomers\", Nat Chem, 9, 353-360", @@ -170705,19 +171115,19 @@ }, { "sim":175.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":175.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":175.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":175.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":175.0, @@ -170725,35 +171135,35 @@ }, { "sim":175.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":175.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":175.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":175.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":175.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":175.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":175.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":175.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":175.0, @@ -170809,7 +171219,7 @@ }, { "sim":171.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":171.0, @@ -170817,7 +171227,7 @@ }, { "sim":171.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":169.0, @@ -170865,11 +171275,11 @@ }, { "sim":158.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":158.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":158.0, @@ -170913,16 +171323,20 @@ }, { "sim":130.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":130.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":129.0, "partner":"2jab" }, + { + "sim":128.0, + "partner":"9glq" + }, { "sim":126.0, "partner":"8aiw" @@ -170997,10 +171411,6 @@ "sim":181.0, "partner":"3nog" }, - { - "sim":180.0, - "partner":"5eno" - }, { "sim":180.0, "partner":"4dx6" @@ -171069,6 +171479,10 @@ "sim":180.0, "partner":"4dx5" }, + { + "sim":180.0, + "partner":"5eno" + }, { "sim":180.0, "partner":"5aq8" @@ -171155,11 +171569,11 @@ }, { "sim":156.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":156.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":140.0, @@ -171295,15 +171709,15 @@ }, { "sim":107.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":107.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":107.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":106.0, @@ -171363,11 +171777,11 @@ }, { "sim":94.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":94.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":93.0, @@ -171637,10 +172051,6 @@ "sim":59.0, "partner":"2rfa" }, - { - "sim":59.0, - "partner":"5iwr" - }, { "sim":59.0, "partner":"5iwt" @@ -171653,6 +172063,10 @@ "sim":59.0, "partner":"5iwp" }, + { + "sim":59.0, + "partner":"5iwr" + }, { "sim":53.0, "partner":"2vge" @@ -171696,6 +172110,10 @@ { "sim":50.0, "partner":"5is0" + }, + { + "sim":50.0, + "partner":"8ycp" } ], "struct_thr_sim_designed":[ @@ -171711,17 +172129,21 @@ "sim":0.9593999982, "partner":"5hry" }, + { + "sim":0.9556000233, + "partner":"6fpb" + }, { "sim":0.9528999925, "partner":"7z7e" }, { - "sim":0.9556000233, - "partner":"6fpb" + "sim":0.9509000182, + "partner":"2xee" }, { - "sim":0.9509999752, - "partner":"6fp9" + "sim":0.956799984, + "partner":"7z7c" }, { "sim":0.9539999962, @@ -171735,17 +172157,13 @@ "sim":0.9535999894, "partner":"7b4w" }, - { - "sim":0.956799984, - "partner":"7z7c" - }, - { - "sim":0.9509000182, - "partner":"2xee" - }, { "sim":0.9502999783, "partner":"5kng" + }, + { + "sim":0.9509999752, + "partner":"6fp9" } ], "struct_thr_sim_natural":[ @@ -171842,13 +172260,13 @@ ], "subtitle":"Crystal structure of e72a mutant of ancestral protein ancmt of adp-dependent sugar kinases family", "tags":[ - "glucokinase", - "enzyme evolution", - "de novo protein", "bifuncional enzymes", - "adp-dependent sugar kinases family", "ancestral protein reconstruction", - "phosphofructokinase" + "de novo protein", + "adp-dependent sugar kinases family", + "enzyme evolution", + "phosphofructokinase", + "glucokinase" ], "keywords":[ "description", @@ -171987,11 +172405,11 @@ }, { "sim":53.0, - "partner":"3zpc" + "partner":"3zpg" }, { "sim":53.0, - "partner":"3zpg" + "partner":"3zpc" }, { "sim":53.0, @@ -172129,14 +172547,6 @@ "sim":51.0, "partner":"2x7j" }, - { - "sim":51.0, - "partner":"4q4e" - }, - { - "sim":51.0, - "partner":"3b34" - }, { "sim":51.0, "partner":"3ked" @@ -172189,6 +172599,14 @@ "sim":51.0, "partner":"3qjx" }, + { + "sim":51.0, + "partner":"4q4e" + }, + { + "sim":51.0, + "partner":"3b34" + }, { "sim":50.0, "partner":"2js3" @@ -172323,83 +172741,83 @@ "alternative scaffold" ], "keywords":[ + "affinity", + "repeats", + "molecular", "interfere", - "analysis", + "resolution", + "repeat", "multiple", - "signaling", - "designed", - "receptor", - "flexibility", + "free", + "various", + "atopic", + "binding", + "site", + "unbound", + "applications", "crystal", - "determined", - "potential", - "unusual", - "repeat", - "instability", - "affinity", - "therapeutic", - "6g9", - "molecule", - "chain", - "proteins", - "employed", - "suggests", - "rigid", + "stable", "binds", - "particularly", - "competes", - "dynamics", - "structures", - "upon", - "advantage", - "operate", - "form", - "shows", - "molecules", "indicates", - "free", - "concerted", - "cap", - "molecular", - "reveals", - "resulted", + "epitope", + "receptor", + "complex", + "simulations", + "flexibility", "asthma", - "opening", - "resolution", - "artificial", - "darpins", - "unbound", + "shows", + "conformational", + "mechanisms", + "particularly", + "rigid", "finding", + "blocks", + "proteins", + "ankyrin", "may", - "mode", + "advantage", + "scaffold", + "since", + "operate", + "molecule", + "signaling", "movement", - "simulations", - "blocks", - "comparison", - "applications", - "high", + "chain", + "suggests", + "cap", + "potential", + "instability", + "therapeutic", + "mode", + "resulted", + "13r\u03b11", + "upon", "promising", - "repeats", - "atopic", - "epitope", - "treatment", - "predicted", "pathway", - "conformational", - "stable", - "ankyrin", - "copies", + "predicted", + "reveals", + "competes", + "concerted", + "unusual", + "darpins", + "dynamics", + "designed", + "form", + "employed", + "analysis", + "6g9", + "opening", + "structures", "darpin", + "copies", + "determined", "state", - "scaffold", - "binding", - "complex", - "mechanisms", - "various", "diseases", - "13r\u03b11", - "site", - "since" + "artificial", + "molecules", + "high", + "treatment", + "comparison" ], "release_date":"2016-12-14", "publication":"\"Conformational flexibility of an anti-IL-13 DARPin\", Protein Eng. Des. Sel., 30, 31-37", @@ -172452,19 +172870,19 @@ }, { "sim":282.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":282.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":282.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":282.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":282.0, @@ -172472,35 +172890,35 @@ }, { "sim":282.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":282.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":282.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":282.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":282.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":282.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":282.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":282.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":281.0, @@ -172520,11 +172938,11 @@ }, { "sim":276.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":276.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":267.0, @@ -172600,7 +173018,7 @@ }, { "sim":256.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":256.0, @@ -172608,7 +173026,7 @@ }, { "sim":256.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":254.0, @@ -172696,11 +173114,11 @@ }, { "sim":222.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":222.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":222.0, @@ -172728,11 +173146,11 @@ }, { "sim":197.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":197.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":196.0, @@ -172758,6 +173176,10 @@ "sim":186.0, "partner":"4hqd" }, + { + "sim":182.0, + "partner":"9glq" + }, { "sim":181.0, "partner":"5kba" @@ -172888,10 +173310,6 @@ "sim":272.0, "partner":"5eyp" }, - { - "sim":271.0, - "partner":"5eno" - }, { "sim":271.0, "partner":"4dx6" @@ -172956,6 +173374,10 @@ "sim":271.0, "partner":"4dx5" }, + { + "sim":271.0, + "partner":"5eno" + }, { "sim":271.0, "partner":"5aqb" @@ -172998,11 +173420,11 @@ }, { "sim":226.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":226.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":217.0, @@ -173134,11 +173556,11 @@ }, { "sim":107.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":107.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":106.0, @@ -173182,15 +173604,15 @@ }, { "sim":104.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":104.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":104.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":102.0, @@ -173436,10 +173858,6 @@ "sim":73.0, "partner":"3hra" }, - { - "sim":73.0, - "partner":"5iwr" - }, { "sim":73.0, "partner":"5iwt" @@ -173453,8 +173871,8 @@ "partner":"5iwp" }, { - "sim":72.0, - "partner":"2a5e" + "sim":73.0, + "partner":"5iwr" }, { "sim":72.0, @@ -173464,6 +173882,10 @@ "sim":72.0, "partner":"1a5e" }, + { + "sim":72.0, + "partner":"2a5e" + }, { "sim":70.0, "partner":"5cea" @@ -173524,6 +173946,10 @@ "sim":60.0, "partner":"1oy3" }, + { + "sim":59.0, + "partner":"8ycp" + }, { "sim":58.0, "partner":"2pnn" @@ -173793,88 +174219,88 @@ ], "subtitle":"Crystal structure of darpin 6g9 in complex with cyno il-13", "tags":[ - "cytokine-de novo protein complex", + "alternative scaffold", "cytokine\/de novo protein", - "alternative scaffold" + "cytokine-de novo protein complex" ], "keywords":[ + "affinity", + "repeats", + "molecular", "interfere", - "analysis", + "resolution", + "repeat", "multiple", - "signaling", - "designed", - "receptor", - "flexibility", + "free", + "various", + "atopic", + "binding", + "site", + "unbound", + "applications", "crystal", - "determined", - "potential", - "unusual", - "repeat", - "instability", - "affinity", - "therapeutic", - "6g9", - "molecule", - "chain", - "proteins", - "employed", - "suggests", - "rigid", + "stable", "binds", - "particularly", - "competes", - "dynamics", - "structures", - "upon", - "advantage", - "operate", - "form", - "shows", - "molecules", "indicates", - "free", - "concerted", - "cap", - "molecular", - "reveals", - "resulted", + "epitope", + "receptor", + "complex", + "simulations", + "flexibility", "asthma", - "opening", - "resolution", - "artificial", - "darpins", - "unbound", + "shows", + "conformational", + "mechanisms", + "particularly", + "rigid", "finding", + "blocks", + "proteins", + "ankyrin", "may", - "mode", + "advantage", + "scaffold", + "since", + "operate", + "molecule", + "signaling", "movement", - "simulations", - "blocks", - "comparison", - "applications", - "high", + "chain", + "suggests", + "cap", + "potential", + "instability", + "therapeutic", + "mode", + "resulted", + "13r\u03b11", + "upon", "promising", - "repeats", - "atopic", - "epitope", - "treatment", - "predicted", "pathway", - "conformational", - "stable", - "ankyrin", - "copies", + "predicted", + "reveals", + "competes", + "concerted", + "unusual", + "darpins", + "dynamics", + "designed", + "form", + "employed", + "analysis", + "6g9", + "opening", + "structures", "darpin", + "copies", + "determined", "state", - "scaffold", - "binding", - "complex", - "mechanisms", - "various", "diseases", - "13r\u03b11", - "site", - "since" + "artificial", + "molecules", + "high", + "treatment", + "comparison" ], "release_date":"2016-12-14", "publication":"\"Conformational flexibility of an anti-IL-13 DARPin\", Protein Eng. Des. Sel., 30, 31-37", @@ -173927,19 +174353,19 @@ }, { "sim":282.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":282.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":282.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":282.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":282.0, @@ -173947,35 +174373,35 @@ }, { "sim":282.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":282.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":282.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":282.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":282.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":282.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":282.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":282.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":281.0, @@ -173995,11 +174421,11 @@ }, { "sim":276.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":276.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":267.0, @@ -174075,7 +174501,7 @@ }, { "sim":256.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":256.0, @@ -174083,7 +174509,7 @@ }, { "sim":256.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":254.0, @@ -174171,11 +174597,11 @@ }, { "sim":222.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":222.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":222.0, @@ -174203,11 +174629,11 @@ }, { "sim":197.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":197.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":196.0, @@ -174233,6 +174659,10 @@ "sim":186.0, "partner":"4hqd" }, + { + "sim":182.0, + "partner":"9glq" + }, { "sim":181.0, "partner":"5kba" @@ -174363,10 +174793,6 @@ "sim":272.0, "partner":"5eyp" }, - { - "sim":271.0, - "partner":"5eno" - }, { "sim":271.0, "partner":"4dx6" @@ -174431,6 +174857,10 @@ "sim":271.0, "partner":"4dx5" }, + { + "sim":271.0, + "partner":"5eno" + }, { "sim":271.0, "partner":"5aqb" @@ -174473,11 +174903,11 @@ }, { "sim":226.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":226.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":217.0, @@ -174609,11 +175039,11 @@ }, { "sim":107.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":107.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":106.0, @@ -174657,15 +175087,15 @@ }, { "sim":104.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":104.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":104.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":102.0, @@ -174911,10 +175341,6 @@ "sim":73.0, "partner":"3hra" }, - { - "sim":73.0, - "partner":"5iwr" - }, { "sim":73.0, "partner":"5iwt" @@ -174928,8 +175354,8 @@ "partner":"5iwp" }, { - "sim":72.0, - "partner":"2a5e" + "sim":73.0, + "partner":"5iwr" }, { "sim":72.0, @@ -174939,6 +175365,10 @@ "sim":72.0, "partner":"1a5e" }, + { + "sim":72.0, + "partner":"2a5e" + }, { "sim":70.0, "partner":"5cea" @@ -174999,6 +175429,10 @@ "sim":60.0, "partner":"1oy3" }, + { + "sim":59.0, + "partner":"8ycp" + }, { "sim":58.0, "partner":"2pnn" @@ -175337,73 +175771,73 @@ ], "subtitle":"Solution nmr structure of denovo beta sheet design protein, northeast structural genomics consortium (nesg) target or664", "tags":[ + "nesg", + "de novo protein", "northeast structural genomics consortium", "structural genomics", - "de novo protein", - "nesg", "psi-biology" ], "keywords":[ - "series", - "sites", - "topped", - "accuracy", - "toward", - "control", + "curvature", + "simulations", "analysis", - "designs", - "\u03b2", - "magnetic", - "proteins", - "models", - "helices", - "investigated", "enables", - "geometry", - "showing", - "approach", - "customized", - "de", - "novo", - "route", - "catalytic", + "often", + "models", "allow", - "would", - "controlled", + "design", + "naturally", "curved", - "used", + "cavities", + "mechanisms", + "investigated", + "controlled", "custom", + "geometry", + "formed", + "principles", "active", - "closely", - "specific", - "simulations", - "nuclear", - "studying", - "crystal", - "often", - "ability", - "occurring", "provides", - "match", - "sheets", - "design", - "controlling", "structures", - "naturally", + "used", + "de", + "topped", + "\u03b2", + "specific", + "route", + "ligands", + "folding", + "closely", + "control", "protein", + "magnetic", + "controlling", + "approach", + "showing", + "sites", + "proteins", + "would", + "binding", + "accuracy", + "sheets", "\u03b1", - "mechanisms", "end", - "cavities", - "resonance", + "ability", + "series", + "novo", "native", - "ligands", - "curvature", + "resonance", + "match", + "customized", + "catalytic", + "toward", + "nuclear", + "crystal", + "helices", + "studying", + "designs", "computational", - "principles", - "folding", - "binding", - "formed", + "occurring", "emerging" ], "release_date":"2016-09-21", @@ -175454,8 +175888,8 @@ ], "struct_max_sim_designed":{ - "sim":0.5271999836, - "partner":"5u35" + "sim":0.5809999704, + "partner":"8vez" }, "struct_max_sim_natural":{ "sim":0.5504000187, @@ -175554,73 +175988,73 @@ ], "subtitle":"Solution nmr structure of denovo beta sheet design protein, northeast structural genomics consortium (nesg) target or485", "tags":[ + "nesg", + "de novo protein", "northeast structural genomics consortium", "structural genomics", - "de novo protein", - "nesg", "psi-biology" ], "keywords":[ - "series", - "sites", - "topped", - "accuracy", - "toward", - "control", + "curvature", + "simulations", "analysis", - "designs", - "\u03b2", - "magnetic", - "proteins", - "models", - "helices", - "investigated", "enables", - "geometry", - "showing", - "approach", - "customized", - "de", - "novo", - "route", - "catalytic", + "often", + "models", "allow", - "would", - "controlled", + "design", + "naturally", "curved", - "used", + "cavities", + "mechanisms", + "investigated", + "controlled", "custom", + "geometry", + "formed", + "principles", "active", - "closely", - "specific", - "simulations", - "nuclear", - "studying", - "crystal", - "often", - "ability", - "occurring", "provides", - "match", - "sheets", - "design", - "controlling", "structures", - "naturally", + "used", + "de", + "topped", + "\u03b2", + "specific", + "route", + "ligands", + "folding", + "closely", + "control", "protein", + "magnetic", + "controlling", + "approach", + "showing", + "sites", + "proteins", + "would", + "binding", + "accuracy", + "sheets", "\u03b1", - "mechanisms", "end", - "cavities", - "resonance", + "ability", + "series", + "novo", "native", - "ligands", - "curvature", + "resonance", + "match", + "customized", + "catalytic", + "toward", + "nuclear", + "crystal", + "helices", + "studying", + "designs", "computational", - "principles", - "folding", - "binding", - "formed", + "occurring", "emerging" ], "release_date":"2016-09-28", @@ -175818,81 +176252,81 @@ ], "subtitle":"Nmr solution structure of designed peptide nc_hee_d1", "tags":[ - "designed peptide", - "de novo protein" + "de novo protein", + "designed peptide" ], "keywords":[ - "stability", - "covalent", - "thermal", - "combining", + "tertiary", + "12", + "models", "generation", - "excellent", - "tissue", + "naturally", + "design", + "constrained", "specified", - "models", - "restricted", - "larger", "specificity", - "use", - "chemical", - "presented", + "development", + "fit", + "methods", + "active", + "nearly", + "therapeutics", + "structures", "de", - "novo", - "stable", - "drugs", + "experimentally", + "combining", "encodable", + "conformationally", + "exceptionally", + "properties", "scaffolds", - "accurate", "pharmacologically", - "peptides", - "enable", - "would", - "subset", - "active", - "shapes", - "provide", - "precisely", - "methods", - "experimentally", - "heterochiral", - "occurring", - "constrained", - "ability", - "crosslinks", - "generally", + "targets", "determined", - "much", - "12", - "design", + "provide", + "residue", "new", + "precisely", + "subset", + "thermal", + "covalent", + "nmr", + "protein", "denaturation", + "inhibitors", "basis", - "therapeutics", - "naturally", - "protein", - "structures", - "residue", - "genetically", - "targets", - "exceptionally", - "pharmaceutical", + "crosslinks", "pockets", - "nmr", - "development", - "describe", - "tertiary", + "stability", + "tissue", + "accurate", + "would", + "generally", + "binding", + "pharmaceutical", + "genetically", + "enable", + "use", + "presented", + "ability", + "shapes", + "novo", + "much", + "heterochiral", + "peptides", + "excellent", + "drugs", + "larger", "identical", - "conformationally", - "arbitrary", - "fit", "penetration", + "chemical", + "arbitrary", + "stable", + "describe", + "restricted", "evolved", - "inhibitors", "computational", - "nearly", - "binding", - "properties" + "occurring" ], "release_date":"2016-09-21", "publication":"\"Accurate de novo design of hyperstable constrained peptides\", Nature, 538, 329-335", @@ -175925,11 +176359,11 @@ "seq_thr_sim_designed":[ { "sim":64.0, - "partner":"6e5h" + "partner":"6e5j" }, { "sim":64.0, - "partner":"6e5j" + "partner":"6e5h" }, { "sim":58.0, @@ -175951,7 +176385,7 @@ ], "seq_max_sim_designed":{ "sim":64.0, - "partner":"6e5h" + "partner":"6e5j" }, "seq_max_sim_natural":[ @@ -176046,90 +176480,90 @@ "subtitle":"Computationally designed symmetric homotetramer", "tags":[ "de novo protein", - "designed protein", + "homooligomer", "ankyrin", - "repeat protein", - "homooligomer" + "designed protein", + "repeat protein" ], "keywords":[ - "cyclically", - "use", + "probe", + "repeat", "complexes", - "scattering", - "close", "idealized", "roles", - "experimentally", - "crystal", - "probe", + "newly", "assess", - "repeat", - "monomer", - "consistent", - "cyclic", - "direct", - "interfaces", + "new", + "model", + "protein", + "homotetramers", + "six", + "rapid", + "close", + "cyclically", "general", - "proteins", - "models", + "crystal", + "stable", + "corresponding", + "monodisperse", "play", - "designability", "characterized", + "formed", + "enumeration", + "experimentally", + "biological", + "consistent", + "cyclic", + "approach", + "proteins", + "use", + "scattering", "interface", - "ability", - "onto", - "structures", - "21", - "solution", - "corresponding", - "function", - "assembly", - "biology", - "form", - "rapid", - "data", - "obtained", - "newly", - "sufficiently", - "generate", - "report", + "found", + "15", + "monomer", "four", - "method", - "approaches", - "six", - "design", - "model", - "followed", - "96", + "sufficiently", + "computational", + "obtained", + "direct", "symmetry", + "design", + "onto", + "biology", + "assembly", + "designability", + "employs", + "solution", + "ability", "sequence", - "biological", "homotrimers", + "docked", + "96", + "method", "could", + "form", + "models", + "interfaces", + "custom", + "one", + "structures", + "approaches", + "21", "important", - "employs", + "possess", + "report", + "followed", + "function", + "homodimers", "homopentamer", - "designs", - "one", - "monodisperse", - "approach", - "stable", + "systematic", "enable", - "custom", - "found", + "data", "arrangements", - "systematic", - "protein", - "enumeration", - "possess", - "15", - "homodimers", - "docked", - "computational", - "homotetramers", - "formed", - "five", - "new" + "designs", + "generate", + "five" ], "release_date":"2017-04-12", "publication":"\"Computational design of self-assembling cyclic protein homo-oligomers\", Nat Chem, 9, 353-360", @@ -176320,81 +176754,81 @@ ], "subtitle":"Nmr solution structure of designed peptide nc_ehe_d1", "tags":[ - "designed peptide", - "de novo protein" + "de novo protein", + "designed peptide" ], "keywords":[ - "stability", - "covalent", - "thermal", - "combining", + "tertiary", + "12", + "models", "generation", - "excellent", - "tissue", + "naturally", + "design", + "constrained", "specified", - "models", - "restricted", - "larger", "specificity", - "use", - "chemical", - "presented", + "development", + "fit", + "methods", + "active", + "nearly", + "therapeutics", + "structures", "de", - "novo", - "stable", - "drugs", + "experimentally", + "combining", "encodable", + "conformationally", + "exceptionally", + "properties", "scaffolds", - "accurate", "pharmacologically", - "peptides", - "enable", - "would", - "subset", - "active", - "shapes", - "provide", - "precisely", - "methods", - "experimentally", - "heterochiral", - "occurring", - "constrained", - "ability", - "crosslinks", - "generally", + "targets", "determined", - "much", - "12", - "design", + "provide", + "residue", "new", + "precisely", + "subset", + "thermal", + "covalent", + "nmr", + "protein", "denaturation", + "inhibitors", "basis", - "therapeutics", - "naturally", - "protein", - "structures", - "residue", - "genetically", - "targets", - "exceptionally", - "pharmaceutical", + "crosslinks", "pockets", - "nmr", - "development", - "describe", - "tertiary", + "stability", + "tissue", + "accurate", + "would", + "generally", + "binding", + "pharmaceutical", + "genetically", + "enable", + "use", + "presented", + "ability", + "shapes", + "novo", + "much", + "heterochiral", + "peptides", + "excellent", + "drugs", + "larger", "identical", - "conformationally", - "arbitrary", - "fit", "penetration", + "chemical", + "arbitrary", + "stable", + "describe", + "restricted", "evolved", - "inhibitors", "computational", - "nearly", - "binding", - "properties" + "occurring" ], "release_date":"2016-09-21", "publication":"\"Accurate de novo design of hyperstable constrained peptides\", Nature, 538, 329-335", @@ -176591,77 +177025,77 @@ "synthetic designed peptide" ], "keywords":[ - "stability", - "covalent", - "thermal", - "combining", + "tertiary", + "12", + "models", "generation", - "excellent", - "tissue", + "naturally", + "design", + "constrained", "specified", - "models", - "restricted", - "larger", "specificity", - "use", - "chemical", - "presented", + "development", + "fit", + "methods", + "active", + "nearly", + "therapeutics", + "structures", "de", - "novo", - "stable", - "drugs", + "experimentally", + "combining", "encodable", + "conformationally", + "exceptionally", + "properties", "scaffolds", - "accurate", "pharmacologically", - "peptides", - "enable", - "would", - "subset", - "active", - "shapes", - "provide", - "precisely", - "methods", - "experimentally", - "heterochiral", - "occurring", - "constrained", - "ability", - "crosslinks", - "generally", + "targets", "determined", - "much", - "12", - "design", + "provide", + "residue", "new", + "precisely", + "subset", + "thermal", + "covalent", + "nmr", + "protein", "denaturation", + "inhibitors", "basis", - "therapeutics", - "naturally", - "protein", - "structures", - "residue", - "genetically", - "targets", - "exceptionally", - "pharmaceutical", + "crosslinks", "pockets", - "nmr", - "development", - "describe", - "tertiary", + "stability", + "tissue", + "accurate", + "would", + "generally", + "binding", + "pharmaceutical", + "genetically", + "enable", + "use", + "presented", + "ability", + "shapes", + "novo", + "much", + "heterochiral", + "peptides", + "excellent", + "drugs", + "larger", "identical", - "conformationally", - "arbitrary", - "fit", "penetration", + "chemical", + "arbitrary", + "stable", + "describe", + "restricted", "evolved", - "inhibitors", "computational", - "nearly", - "binding", - "properties" + "occurring" ], "release_date":"2016-09-21", "publication":"\"Accurate de novo design of hyperstable constrained peptides\", Nature, 538, 329-335", @@ -176853,81 +177287,81 @@ ], "subtitle":"Nmr solution structure of designed peptide nc_eeh_d1", "tags":[ - "designed peptide", - "de novo protein" + "de novo protein", + "designed peptide" ], "keywords":[ - "stability", - "covalent", - "thermal", - "combining", + "tertiary", + "12", + "models", "generation", - "excellent", - "tissue", + "naturally", + "design", + "constrained", "specified", - "models", - "restricted", - "larger", "specificity", - "use", - "chemical", - "presented", + "development", + "fit", + "methods", + "active", + "nearly", + "therapeutics", + "structures", "de", - "novo", - "stable", - "drugs", + "experimentally", + "combining", "encodable", + "conformationally", + "exceptionally", + "properties", "scaffolds", - "accurate", "pharmacologically", - "peptides", - "enable", - "would", - "subset", - "active", - "shapes", - "provide", - "precisely", - "methods", - "experimentally", - "heterochiral", - "occurring", - "constrained", - "ability", - "crosslinks", - "generally", + "targets", "determined", - "much", - "12", - "design", + "provide", + "residue", "new", + "precisely", + "subset", + "thermal", + "covalent", + "nmr", + "protein", "denaturation", + "inhibitors", "basis", - "therapeutics", - "naturally", - "protein", - "structures", - "residue", - "genetically", - "targets", - "exceptionally", - "pharmaceutical", + "crosslinks", "pockets", - "nmr", - "development", - "describe", - "tertiary", + "stability", + "tissue", + "accurate", + "would", + "generally", + "binding", + "pharmaceutical", + "genetically", + "enable", + "use", + "presented", + "ability", + "shapes", + "novo", + "much", + "heterochiral", + "peptides", + "excellent", + "drugs", + "larger", "identical", - "conformationally", - "arbitrary", - "fit", "penetration", + "chemical", + "arbitrary", + "stable", + "describe", + "restricted", "evolved", - "inhibitors", "computational", - "nearly", - "binding", - "properties" + "occurring" ], "release_date":"2016-09-21", "publication":"\"Accurate de novo design of hyperstable constrained peptides\", Nature, 538, 329-335", @@ -177119,81 +177553,81 @@ ], "subtitle":"Nmr solution structure of designed peptide nc_chh_d1", "tags":[ - "designed peptide", - "de novo protein" + "de novo protein", + "designed peptide" ], "keywords":[ - "stability", - "covalent", - "thermal", - "combining", + "tertiary", + "12", + "models", "generation", - "excellent", - "tissue", + "naturally", + "design", + "constrained", "specified", - "models", - "restricted", - "larger", "specificity", - "use", - "chemical", - "presented", + "development", + "fit", + "methods", + "active", + "nearly", + "therapeutics", + "structures", "de", - "novo", - "stable", - "drugs", + "experimentally", + "combining", "encodable", + "conformationally", + "exceptionally", + "properties", "scaffolds", - "accurate", "pharmacologically", - "peptides", - "enable", - "would", - "subset", - "active", - "shapes", - "provide", - "precisely", - "methods", - "experimentally", - "heterochiral", - "occurring", - "constrained", - "ability", - "crosslinks", - "generally", + "targets", "determined", - "much", - "12", - "design", + "provide", + "residue", "new", + "precisely", + "subset", + "thermal", + "covalent", + "nmr", + "protein", "denaturation", + "inhibitors", "basis", - "therapeutics", - "naturally", - "protein", - "structures", - "residue", - "genetically", - "targets", - "exceptionally", - "pharmaceutical", + "crosslinks", "pockets", - "nmr", - "development", - "describe", - "tertiary", + "stability", + "tissue", + "accurate", + "would", + "generally", + "binding", + "pharmaceutical", + "genetically", + "enable", + "use", + "presented", + "ability", + "shapes", + "novo", + "much", + "heterochiral", + "peptides", + "excellent", + "drugs", + "larger", "identical", - "conformationally", - "arbitrary", - "fit", "penetration", + "chemical", + "arbitrary", + "stable", + "describe", + "restricted", "evolved", - "inhibitors", "computational", - "nearly", - "binding", - "properties" + "occurring" ], "release_date":"2016-09-21", "publication":"\"Accurate de novo design of hyperstable constrained peptides\", Nature, 538, 329-335", @@ -177386,81 +177820,81 @@ ], "subtitle":"Nmr solution structure of designed peptide nc_chh_dl_d1", "tags":[ - "designed peptide", - "de novo protein" + "de novo protein", + "designed peptide" ], "keywords":[ - "stability", - "covalent", - "thermal", - "combining", + "tertiary", + "12", + "models", "generation", - "excellent", - "tissue", + "naturally", + "design", + "constrained", "specified", - "models", - "restricted", - "larger", "specificity", - "use", - "chemical", - "presented", + "development", + "fit", + "methods", + "active", + "nearly", + "therapeutics", + "structures", "de", - "novo", - "stable", - "drugs", + "experimentally", + "combining", "encodable", + "conformationally", + "exceptionally", + "properties", "scaffolds", - "accurate", "pharmacologically", - "peptides", - "enable", - "would", - "subset", - "active", - "shapes", - "provide", - "precisely", - "methods", - "experimentally", - "heterochiral", - "occurring", - "constrained", - "ability", - "crosslinks", - "generally", + "targets", "determined", - "much", - "12", - "design", + "provide", + "residue", "new", + "precisely", + "subset", + "thermal", + "covalent", + "nmr", + "protein", "denaturation", + "inhibitors", "basis", - "therapeutics", - "naturally", - "protein", - "structures", - "residue", - "genetically", - "targets", - "exceptionally", - "pharmaceutical", + "crosslinks", "pockets", - "nmr", - "development", - "describe", - "tertiary", + "stability", + "tissue", + "accurate", + "would", + "generally", + "binding", + "pharmaceutical", + "genetically", + "enable", + "use", + "presented", + "ability", + "shapes", + "novo", + "much", + "heterochiral", + "peptides", + "excellent", + "drugs", + "larger", "identical", - "conformationally", - "arbitrary", - "fit", "penetration", + "chemical", + "arbitrary", + "stable", + "describe", + "restricted", "evolved", - "inhibitors", "computational", - "nearly", - "binding", - "properties" + "occurring" ], "release_date":"2016-09-21", "publication":"\"Accurate de novo design of hyperstable constrained peptides\", Nature, 538, 329-335", @@ -177651,81 +178085,81 @@ ], "subtitle":"Nmr solution structure of designed peptide nc_chhh_d1", "tags":[ - "designed peptide", - "de novo protein" + "de novo protein", + "designed peptide" ], "keywords":[ - "stability", - "covalent", - "thermal", - "combining", + "tertiary", + "12", + "models", "generation", - "excellent", - "tissue", + "naturally", + "design", + "constrained", "specified", - "models", - "restricted", - "larger", "specificity", - "use", - "chemical", - "presented", + "development", + "fit", + "methods", + "active", + "nearly", + "therapeutics", + "structures", "de", - "novo", - "stable", - "drugs", + "experimentally", + "combining", "encodable", + "conformationally", + "exceptionally", + "properties", "scaffolds", - "accurate", "pharmacologically", - "peptides", - "enable", - "would", - "subset", - "active", - "shapes", - "provide", - "precisely", - "methods", - "experimentally", - "heterochiral", - "occurring", - "constrained", - "ability", - "crosslinks", - "generally", + "targets", "determined", - "much", - "12", - "design", + "provide", + "residue", "new", + "precisely", + "subset", + "thermal", + "covalent", + "nmr", + "protein", "denaturation", + "inhibitors", "basis", - "therapeutics", - "naturally", - "protein", - "structures", - "residue", - "genetically", - "targets", - "exceptionally", - "pharmaceutical", + "crosslinks", "pockets", - "nmr", - "development", - "describe", - "tertiary", + "stability", + "tissue", + "accurate", + "would", + "generally", + "binding", + "pharmaceutical", + "genetically", + "enable", + "use", + "presented", + "ability", + "shapes", + "novo", + "much", + "heterochiral", + "peptides", + "excellent", + "drugs", + "larger", "identical", - "conformationally", - "arbitrary", - "fit", "penetration", + "chemical", + "arbitrary", + "stable", + "describe", + "restricted", "evolved", - "inhibitors", "computational", - "nearly", - "binding", - "properties" + "occurring" ], "release_date":"2016-09-21", "publication":"\"Accurate de novo design of hyperstable constrained peptides\", Nature, 538, 329-335", @@ -177920,77 +178354,77 @@ "synthetic designed peptide" ], "keywords":[ - "stability", - "covalent", - "thermal", - "combining", + "tertiary", + "12", + "models", "generation", - "excellent", - "tissue", + "naturally", + "design", + "constrained", "specified", - "models", - "restricted", - "larger", "specificity", - "use", - "chemical", - "presented", + "development", + "fit", + "methods", + "active", + "nearly", + "therapeutics", + "structures", "de", - "novo", - "stable", - "drugs", + "experimentally", + "combining", "encodable", + "conformationally", + "exceptionally", + "properties", "scaffolds", - "accurate", "pharmacologically", - "peptides", - "enable", - "would", - "subset", - "active", - "shapes", - "provide", - "precisely", - "methods", - "experimentally", - "heterochiral", - "occurring", - "constrained", - "ability", - "crosslinks", - "generally", + "targets", "determined", - "much", - "12", - "design", + "provide", + "residue", "new", + "precisely", + "subset", + "thermal", + "covalent", + "nmr", + "protein", "denaturation", + "inhibitors", "basis", - "therapeutics", - "naturally", - "protein", - "structures", - "residue", - "genetically", - "targets", - "exceptionally", - "pharmaceutical", + "crosslinks", "pockets", - "nmr", - "development", - "describe", - "tertiary", + "stability", + "tissue", + "accurate", + "would", + "generally", + "binding", + "pharmaceutical", + "genetically", + "enable", + "use", + "presented", + "ability", + "shapes", + "novo", + "much", + "heterochiral", + "peptides", + "excellent", + "drugs", + "larger", "identical", - "conformationally", - "arbitrary", - "fit", "penetration", + "chemical", + "arbitrary", + "stable", + "describe", + "restricted", "evolved", - "inhibitors", "computational", - "nearly", - "binding", - "properties" + "occurring" ], "release_date":"2016-09-21", "publication":"\"Accurate de novo design of hyperstable constrained peptides\", Nature, 538, 329-335", @@ -178109,99 +178543,99 @@ ], "subtitle":"Crystal structure of w26a mutant of anti-egfr centyrin p54ar4-83v2", "tags":[ - "scaffold protein", "de novo protein", "beta sandwich", - "fibronectin type iii" + "fibronectin type iii", + "scaffold protein" ], "keywords":[ - "domain", - "interpretation", - "delivering", - "providing", + "engineering", "26", - "comprehensive", - "conjugation", - "linker", + "development", + "structural", "candidate", - "provide", - "pathways", + "via", + "delivery", + "retention", + "protein", + "study", + "positions", + "mapped", + "binding", + "cellular", + "site", + "tissues", + "covalently", + "purification", "crystal", - "target", - "94", - "expression", - "structure", - "centyrin", - "therapeutic", - "molecule", - "modification", - "proteins", - "receptors", - "cell", - "modern", - "cytotoxic", - "payload", + "stable", + "chemistry", + "component", + "conjugation", + "interpretation", + "linker", + "delivering", + "ideal", + "payloads", "influence", - "small", + "overall", + "identified", + "specific", + "comprehensive", + "address", + "optimization", + "proteins", + "experiment", + "iii", + "scaffold", "highly", - "targeted", - "covalently", - "retention", + "small", + "cytotoxic", + "linked", + "pathways", + "wherein", + "molecule", + "mutagenesis", "replacements", - "purification", - "efficiency", - "experiment", + "intracellular", "onto", - "positions", - "trafficking", - "foundation", - "linked", - "cellular", + "context", + "fn3", + "modern", + "possible", + "domain", + "properties", "platform", "targeting", - "properties", - "fn3", - "via", - "egfr", - "optimization", - "address", - "iii", - "specific", - "engineering", - "type", - "context", - "pharmaceutical", - "describe", - "structural", - "important", - "mapped", - "delivery", - "overall", + "centyrin", "cysteine", - "chemistry", - "study", - "stable", - "fibronectin", - "intracellular", - "drug", - "identified", - "tissues", - "ideal", - "scaffold", - "wherein", - "binding", - "protein", - "payloads", - "development", + "therapeutic", + "cell", "potency", + "trafficking", + "type", + "foundation", "types", + "payload", "evaluated", - "component", - "antibodies", - "possible", - "site", + "describe", + "94", + "modification", + "targeted", + "receptors", + "providing", + "important", + "structure", + "provide", + "target", + "fibronectin", "biophysical", - "mutagenesis" + "drug", + "pharmaceutical", + "expression", + "egfr", + "efficiency", + "antibodies" ], "release_date":"2016-11-02", "publication":"\"Engineering a targeted delivery platform using Centyrins\", Protein Eng. Des. Sel., 29, 563-572", @@ -178514,66 +178948,66 @@ "de novo ntf2" ], "keywords":[ - "series", - "sites", - "topped", - "accuracy", - "toward", - "control", + "curvature", + "simulations", "analysis", - "designs", - "\u03b2", - "magnetic", - "proteins", - "models", - "helices", - "investigated", "enables", - "geometry", - "showing", - "approach", - "customized", - "de", - "novo", - "route", - "catalytic", + "often", + "models", "allow", - "would", - "controlled", + "design", + "naturally", "curved", - "used", + "cavities", + "mechanisms", + "investigated", + "controlled", "custom", + "geometry", + "formed", + "principles", "active", - "closely", - "specific", - "simulations", - "nuclear", - "studying", - "crystal", - "often", - "ability", - "occurring", "provides", - "match", - "sheets", - "design", - "controlling", "structures", - "naturally", + "used", + "de", + "topped", + "\u03b2", + "specific", + "route", + "ligands", + "folding", + "closely", + "control", "protein", + "magnetic", + "controlling", + "approach", + "showing", + "sites", + "proteins", + "would", + "binding", + "accuracy", + "sheets", "\u03b1", - "mechanisms", "end", - "cavities", - "resonance", + "ability", + "series", + "novo", "native", - "ligands", - "curvature", + "resonance", + "match", + "customized", + "catalytic", + "toward", + "nuclear", + "crystal", + "helices", + "studying", + "designs", "computational", - "principles", - "folding", - "binding", - "formed", + "occurring", "emerging" ], "release_date":"2017-01-25", @@ -178698,100 +179132,100 @@ ], "subtitle":"Crystal structure of darpin-darpin rigid fusion, variant ddd_d12_15_d12_15_d12", "tags":[ - "x-ray crystallography; designed ankyrin repeat proteins; protein design; protein engineering; rigid domain fusions", - "de novo protein" + "de novo protein", + "x-ray crystallography; designed ankyrin repeat proteins; protein design; protein engineering; rigid domain fusions" ], "keywords":[ + "repeats", + "individual", + "ease", + "repeat", + "simultaneously", + "localization", + "crystallize", + "make", + "protein", + "study", + "activities", + "vitro", + "binding", + "together", + "multispecific", + "demonstrate", + "two", "confirm", - "constructs", + "connector", + "complex", + "flexibility", + "conformational", + "subcellular", + "formed", + "able", + "ideal", "us", - "use", - "compromising", - "selection", + "biological", + "rigid", + "helix", + "changing", + "bind", + "stability", + "exploiting", + "blocks", + "proteins", "modules", - "scaffolds", - "crystallography", - "designed", + "eight", + "use", + "multivalent", + "modular", + "ankyrin", + "units", + "bispecific", + "scaffold", + "restricting", "geometries", - "flexibility", - "target", + "design", + "joined", + "selection", + "binders", + "different", + "beyond", + "build", + "allows", + "building", + "method", + "darpins", "shared", - "join", - "bispecific", + "production", + "designed", + "one", + "way", + "avoiding", + "specificities", + "constructs", "based", + "darpin", + "without", + "predefined", "synthetic", - "bind", + "bringing", + "scaffolds", + "nine", "structure", - "repeat", - "able", - "building", - "without", - "allows", - "proteins", - "restricting", - "localization", - "rigid", - "binders", - "beyond", + "flexible", + "target", + "crystallography", "nature", - "vitro", - "production", - "units", - "individual", "capping", - "ease", - "molecules", - "joined", - "simultaneously", - "subcellular", - "stability", - "predefined", - "multivalent", + "yield", "linkers", - "activities", - "darpins", - "method", - "specificities", + "molecules", "gain", - "blocks", - "design", "high", - "bringing", - "repeats", - "biological", - "connector", - "inherent", - "make", - "demonstrate", - "eight", - "one", - "build", - "conformational", - "avoiding", - "study", - "flexible", - "way", - "together", - "modular", - "different", - "ankyrin", - "darpin", - "changing", - "affinities", - "two", - "exploiting", - "ideal", - "scaffold", - "protein", - "yield", - "complex", - "helix", - "nine", + "compromising", "distinct", - "multispecific", - "binding", - "formed", - "crystallize" + "affinities", + "join", + "inherent" ], "release_date":"2017-08-02", "publication":"\"Rigidly connected multispecific artificial binders with adjustable geometries\", Sci Rep, 7, 11217-11217", @@ -178824,7 +179258,7 @@ "seq_thr_sim_designed":[ { "sim":936.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":936.0, @@ -178832,7 +179266,7 @@ }, { "sim":936.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":897.0, @@ -178924,47 +179358,47 @@ }, { "sim":256.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":256.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":256.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":256.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":256.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":256.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":256.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":256.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":256.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":256.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":256.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":256.0, @@ -178972,15 +179406,15 @@ }, { "sim":256.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":256.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":256.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":256.0, @@ -179020,15 +179454,15 @@ }, { "sim":243.0, - "partner":"7b4t" + "partner":"6fpb" }, { "sim":243.0, - "partner":"6fpb" + "partner":"6fpa" }, { "sim":243.0, - "partner":"6fpa" + "partner":"7b4t" }, { "sim":242.0, @@ -179048,11 +179482,11 @@ }, { "sim":238.0, - "partner":"7z72" + "partner":"7z71" }, { "sim":238.0, - "partner":"7z71" + "partner":"7z72" }, { "sim":238.0, @@ -179128,11 +179562,11 @@ }, { "sim":183.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":183.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":183.0, @@ -179158,6 +179592,10 @@ "sim":173.0, "partner":"5kba" }, + { + "sim":171.0, + "partner":"9glq" + }, { "sim":171.0, "partner":"4hb5" @@ -179268,10 +179706,6 @@ "sim":258.0, "partner":"5jhq" }, - { - "sim":257.0, - "partner":"5eno" - }, { "sim":257.0, "partner":"4dx6" @@ -179340,6 +179774,10 @@ "sim":257.0, "partner":"4dx5" }, + { + "sim":257.0, + "partner":"5eno" + }, { "sim":256.0, "partner":"3zu7" @@ -179430,11 +179868,11 @@ }, { "sim":211.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":211.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":207.0, @@ -179646,15 +180084,15 @@ }, { "sim":109.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":109.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":109.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":109.0, @@ -179674,11 +180112,11 @@ }, { "sim":106.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":106.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":106.0, @@ -179742,11 +180180,11 @@ }, { "sim":95.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":95.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":94.0, @@ -179952,10 +180390,6 @@ "sim":67.0, "partner":"1oy3" }, - { - "sim":66.0, - "partner":"5iwr" - }, { "sim":66.0, "partner":"5iwt" @@ -179969,8 +180403,8 @@ "partner":"5iwp" }, { - "sim":65.0, - "partner":"2a5e" + "sim":66.0, + "partner":"5iwr" }, { "sim":65.0, @@ -179980,6 +180414,10 @@ "sim":65.0, "partner":"1a5e" }, + { + "sim":65.0, + "partner":"2a5e" + }, { "sim":64.0, "partner":"5d68" @@ -180044,6 +180482,10 @@ "sim":53.0, "partner":"4bet" }, + { + "sim":53.0, + "partner":"8ycp" + }, { "sim":51.0, "partner":"2pnn" @@ -180111,7 +180553,7 @@ ], "seq_max_sim_designed":{ "sim":936.0, - "partner":"5lec" + "partner":"5lee" }, "seq_max_sim_natural":{ "sim":495.0, @@ -180177,103 +180619,103 @@ ], "subtitle":"Crystal structure of darpin-darpin rigid fusion, variant dd_d12_09_d12", "tags":[ - "rigid domain fusions", "designed ankyrin repeat proteins", - "protein engineering", "de novo protein", + "rigid domain fusions", + "protein engineering", "protein design" ], "keywords":[ + "repeats", + "individual", + "ease", + "repeat", + "simultaneously", + "localization", + "crystallize", + "make", + "protein", + "study", + "activities", + "vitro", + "binding", + "together", + "multispecific", + "demonstrate", + "two", "confirm", - "constructs", + "connector", + "complex", + "flexibility", + "conformational", + "subcellular", + "formed", + "able", + "ideal", "us", - "use", - "compromising", - "selection", + "biological", + "rigid", + "helix", + "changing", + "bind", + "stability", + "exploiting", + "blocks", + "proteins", "modules", - "scaffolds", - "crystallography", - "designed", + "eight", + "use", + "multivalent", + "modular", + "ankyrin", + "units", + "bispecific", + "scaffold", + "restricting", "geometries", - "flexibility", - "target", + "design", + "joined", + "selection", + "binders", + "different", + "beyond", + "build", + "allows", + "building", + "method", + "darpins", "shared", - "join", - "bispecific", + "production", + "designed", + "one", + "way", + "avoiding", + "specificities", + "constructs", "based", + "darpin", + "without", + "predefined", "synthetic", - "bind", + "bringing", + "scaffolds", + "nine", "structure", - "repeat", - "able", - "building", - "without", - "allows", - "proteins", - "restricting", - "localization", - "rigid", - "binders", - "beyond", + "flexible", + "target", + "crystallography", "nature", - "vitro", - "production", - "units", - "individual", "capping", - "ease", - "molecules", - "joined", - "simultaneously", - "subcellular", - "stability", - "predefined", - "multivalent", + "yield", "linkers", - "activities", - "darpins", - "method", - "specificities", + "molecules", "gain", - "blocks", - "design", "high", - "bringing", - "repeats", - "biological", - "connector", - "inherent", - "make", - "demonstrate", - "eight", - "one", - "build", - "conformational", - "avoiding", - "study", - "flexible", - "way", - "together", - "modular", - "different", - "ankyrin", - "darpin", - "changing", - "affinities", - "two", - "exploiting", - "ideal", - "scaffold", - "protein", - "yield", - "complex", - "helix", - "nine", + "compromising", "distinct", - "multispecific", - "binding", - "formed", - "crystallize" + "affinities", + "join", + "inherent" ], "release_date":"2017-08-02", "publication":"\"Rigidly connected multispecific artificial binders with adjustable geometries\", Sci Rep, 7, 11217-11217", @@ -180330,7 +180772,7 @@ }, { "sim":586.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":586.0, @@ -180338,7 +180780,7 @@ }, { "sim":586.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":513.0, @@ -180410,47 +180852,47 @@ }, { "sim":252.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":252.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":252.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":252.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":252.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":252.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":252.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":252.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":252.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":252.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":252.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":252.0, @@ -180458,15 +180900,15 @@ }, { "sim":252.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":252.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":252.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":252.0, @@ -180518,15 +180960,15 @@ }, { "sim":239.0, - "partner":"7b4t" + "partner":"6fpb" }, { "sim":239.0, - "partner":"6fpb" + "partner":"6fpa" }, { "sim":239.0, - "partner":"6fpa" + "partner":"7b4t" }, { "sim":238.0, @@ -180614,16 +181056,20 @@ }, { "sim":179.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":179.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":174.0, "partner":"4hqd" }, + { + "sim":171.0, + "partner":"9glq" + }, { "sim":170.0, "partner":"9f23" @@ -180746,10 +181192,6 @@ "sim":254.0, "partner":"4hna" }, - { - "sim":253.0, - "partner":"5eno" - }, { "sim":253.0, "partner":"4dx6" @@ -180818,6 +181260,10 @@ "sim":253.0, "partner":"4dx5" }, + { + "sim":253.0, + "partner":"5eno" + }, { "sim":252.0, "partner":"3zu7" @@ -180896,11 +181342,11 @@ }, { "sim":209.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":209.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":208.0, @@ -181100,11 +181546,11 @@ }, { "sim":110.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":110.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":109.0, @@ -181192,11 +181638,11 @@ }, { "sim":98.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":98.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":96.0, @@ -181378,10 +181824,6 @@ "sim":73.0, "partner":"3t9k" }, - { - "sim":73.0, - "partner":"5iwr" - }, { "sim":73.0, "partner":"5iwt" @@ -181394,6 +181836,10 @@ "sim":73.0, "partner":"5iwp" }, + { + "sim":73.0, + "partner":"5iwr" + }, { "sim":71.0, "partner":"5cea" @@ -181440,15 +181886,15 @@ }, { "sim":65.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":65.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":65.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":64.0, @@ -181502,6 +181948,10 @@ "sim":55.0, "partner":"5an8" }, + { + "sim":54.0, + "partner":"8ycp" + }, { "sim":53.0, "partner":"4ber" @@ -181633,100 +182083,100 @@ ], "subtitle":"Crystal structure of darpin-darpin rigid fusion, variant dd_d12_11_d12", "tags":[ - "x-ray crystallography; designed ankyrin repeat proteins; protein design; protein engineering; rigid domain fusions", - "de novo protein" + "de novo protein", + "x-ray crystallography; designed ankyrin repeat proteins; protein design; protein engineering; rigid domain fusions" ], "keywords":[ + "repeats", + "individual", + "ease", + "repeat", + "simultaneously", + "localization", + "crystallize", + "make", + "protein", + "study", + "activities", + "vitro", + "binding", + "together", + "multispecific", + "demonstrate", + "two", "confirm", - "constructs", + "connector", + "complex", + "flexibility", + "conformational", + "subcellular", + "formed", + "able", + "ideal", "us", - "use", - "compromising", - "selection", + "biological", + "rigid", + "helix", + "changing", + "bind", + "stability", + "exploiting", + "blocks", + "proteins", "modules", - "scaffolds", - "crystallography", - "designed", + "eight", + "use", + "multivalent", + "modular", + "ankyrin", + "units", + "bispecific", + "scaffold", + "restricting", "geometries", - "flexibility", - "target", + "design", + "joined", + "selection", + "binders", + "different", + "beyond", + "build", + "allows", + "building", + "method", + "darpins", "shared", - "join", - "bispecific", + "production", + "designed", + "one", + "way", + "avoiding", + "specificities", + "constructs", "based", + "darpin", + "without", + "predefined", "synthetic", - "bind", + "bringing", + "scaffolds", + "nine", "structure", - "repeat", - "able", - "building", - "without", - "allows", - "proteins", - "restricting", - "localization", - "rigid", - "binders", - "beyond", + "flexible", + "target", + "crystallography", "nature", - "vitro", - "production", - "units", - "individual", "capping", - "ease", - "molecules", - "joined", - "simultaneously", - "subcellular", - "stability", - "predefined", - "multivalent", + "yield", "linkers", - "activities", - "darpins", - "method", - "specificities", + "molecules", "gain", - "blocks", - "design", "high", - "bringing", - "repeats", - "biological", - "connector", - "inherent", - "make", - "demonstrate", - "eight", - "one", - "build", - "conformational", - "avoiding", - "study", - "flexible", - "way", - "together", - "modular", - "different", - "ankyrin", - "darpin", - "changing", - "affinities", - "two", - "exploiting", - "ideal", - "scaffold", - "protein", - "yield", - "complex", - "helix", - "nine", + "compromising", "distinct", - "multispecific", - "binding", - "formed", - "crystallize" + "affinities", + "join", + "inherent" ], "release_date":"2017-08-02", "publication":"\"Rigidly connected multispecific artificial binders with adjustable geometries\", Sci Rep, 7, 11217-11217", @@ -181779,7 +182229,7 @@ }, { "sim":604.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":604.0, @@ -181787,7 +182237,7 @@ }, { "sim":604.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":594.0, @@ -181863,47 +182313,47 @@ }, { "sim":250.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":250.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":250.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":250.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":250.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":250.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":250.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":250.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":250.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":250.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":250.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":250.0, @@ -181911,15 +182361,15 @@ }, { "sim":250.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":250.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":250.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":250.0, @@ -182071,11 +182521,15 @@ }, { "sim":176.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":176.0, - "partner":"7b4u" + "partner":"7b4v" + }, + { + "sim":171.0, + "partner":"9glq" }, { "sim":170.0, @@ -182083,11 +182537,11 @@ }, { "sim":169.0, - "partner":"5kba" + "partner":"4gpm" }, { "sim":169.0, - "partner":"4gpm" + "partner":"5kba" }, { "sim":169.0, @@ -182191,10 +182645,6 @@ "sim":252.0, "partner":"4hna" }, - { - "sim":250.0, - "partner":"5eno" - }, { "sim":250.0, "partner":"4dx6" @@ -182271,6 +182721,10 @@ "sim":250.0, "partner":"4dx5" }, + { + "sim":250.0, + "partner":"5eno" + }, { "sim":249.0, "partner":"3zu7" @@ -182349,11 +182803,11 @@ }, { "sim":205.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":205.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":205.0, @@ -182577,11 +183031,11 @@ }, { "sim":105.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":105.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":104.0, @@ -182637,11 +183091,11 @@ }, { "sim":94.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":94.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":94.0, @@ -182823,10 +183277,6 @@ "sim":73.0, "partner":"3t9k" }, - { - "sim":73.0, - "partner":"5iwr" - }, { "sim":73.0, "partner":"5iwt" @@ -182839,6 +183289,10 @@ "sim":73.0, "partner":"5iwp" }, + { + "sim":73.0, + "partner":"5iwr" + }, { "sim":72.0, "partner":"2rfa" @@ -182889,15 +183343,15 @@ }, { "sim":65.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":65.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":65.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":65.0, @@ -182931,6 +183385,10 @@ "sim":57.0, "partner":"5u0k" }, + { + "sim":56.0, + "partner":"8ycp" + }, { "sim":55.0, "partner":"5u0i" @@ -183104,103 +183562,103 @@ ], "subtitle":"Crystal structure of darpin-darpin rigid fusion, variant dd_d12_09_d12", "tags":[ - "rigid domain fusions", "designed ankyrin repeat proteins", - "protein engineering", "de novo protein", + "rigid domain fusions", + "protein engineering", "protein design" ], "keywords":[ + "repeats", + "individual", + "ease", + "repeat", + "simultaneously", + "localization", + "crystallize", + "make", + "protein", + "study", + "activities", + "vitro", + "binding", + "together", + "multispecific", + "demonstrate", + "two", "confirm", - "constructs", + "connector", + "complex", + "flexibility", + "conformational", + "subcellular", + "formed", + "able", + "ideal", "us", - "use", - "compromising", - "selection", + "biological", + "rigid", + "helix", + "changing", + "bind", + "stability", + "exploiting", + "blocks", + "proteins", "modules", - "scaffolds", - "crystallography", - "designed", + "eight", + "use", + "multivalent", + "modular", + "ankyrin", + "units", + "bispecific", + "scaffold", + "restricting", "geometries", - "flexibility", - "target", + "design", + "joined", + "selection", + "binders", + "different", + "beyond", + "build", + "allows", + "building", + "method", + "darpins", "shared", - "join", - "bispecific", + "production", + "designed", + "one", + "way", + "avoiding", + "specificities", + "constructs", "based", + "darpin", + "without", + "predefined", "synthetic", - "bind", + "bringing", + "scaffolds", + "nine", "structure", - "repeat", - "able", - "building", - "without", - "allows", - "proteins", - "restricting", - "localization", - "rigid", - "binders", - "beyond", + "flexible", + "target", + "crystallography", "nature", - "vitro", - "production", - "units", - "individual", "capping", - "ease", - "molecules", - "joined", - "simultaneously", - "subcellular", - "stability", - "predefined", - "multivalent", + "yield", "linkers", - "activities", - "darpins", - "method", - "specificities", + "molecules", "gain", - "blocks", - "design", "high", - "bringing", - "repeats", - "biological", - "connector", - "inherent", - "make", - "demonstrate", - "eight", - "one", - "build", - "conformational", - "avoiding", - "study", - "flexible", - "way", - "together", - "modular", - "different", - "ankyrin", - "darpin", - "changing", - "affinities", - "two", - "exploiting", - "ideal", - "scaffold", - "protein", - "yield", - "complex", - "helix", - "nine", + "compromising", "distinct", - "multispecific", - "binding", - "formed", - "crystallize" + "affinities", + "join", + "inherent" ], "release_date":"2017-08-02", "publication":"\"Rigidly connected multispecific artificial binders with adjustable geometries\", Sci Rep, 7, 11217-11217", @@ -183257,7 +183715,7 @@ }, { "sim":601.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":601.0, @@ -183265,7 +183723,7 @@ }, { "sim":601.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":556.0, @@ -183337,47 +183795,47 @@ }, { "sim":252.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":252.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":252.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":252.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":252.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":252.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":252.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":252.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":252.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":252.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":252.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":252.0, @@ -183385,15 +183843,15 @@ }, { "sim":252.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":252.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":252.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":251.0, @@ -183545,16 +184003,20 @@ }, { "sim":178.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":178.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":172.0, "partner":"5kba" }, + { + "sim":171.0, + "partner":"9glq" + }, { "sim":171.0, "partner":"4gmr" @@ -183669,10 +184131,6 @@ "sim":252.0, "partner":"2v5q" }, - { - "sim":252.0, - "partner":"5eno" - }, { "sim":252.0, "partner":"4dx6" @@ -183749,6 +184207,10 @@ "sim":252.0, "partner":"4dx5" }, + { + "sim":252.0, + "partner":"5eno" + }, { "sim":252.0, "partner":"5aqa" @@ -183827,11 +184289,11 @@ }, { "sim":209.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":209.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":206.0, @@ -184023,11 +184485,11 @@ }, { "sim":112.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":112.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":111.0, @@ -184067,15 +184529,15 @@ }, { "sim":110.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":110.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":110.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":108.0, @@ -184155,11 +184617,11 @@ }, { "sim":95.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":95.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":94.0, @@ -184341,10 +184803,6 @@ "sim":72.0, "partner":"5ced" }, - { - "sim":72.0, - "partner":"5iwr" - }, { "sim":72.0, "partner":"5iwt" @@ -184357,6 +184815,10 @@ "sim":72.0, "partner":"5iwp" }, + { + "sim":72.0, + "partner":"5iwr" + }, { "sim":70.0, "partner":"1k3z" @@ -184399,15 +184861,15 @@ }, { "sim":65.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":65.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":65.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":64.0, @@ -184429,6 +184891,10 @@ "sim":56.0, "partner":"3ui2" }, + { + "sim":56.0, + "partner":"8ycp" + }, { "sim":55.0, "partner":"5u0i" @@ -184576,103 +185042,103 @@ ], "subtitle":"Crystal structure of darpin-darpin rigid fusion, variant dd_d12_13_d12", "tags":[ - "rigid domain fusions", "designed ankyrin repeat proteins", - "protein engineering", "de novo protein", + "rigid domain fusions", + "protein engineering", "protein design" ], "keywords":[ + "repeats", + "individual", + "ease", + "repeat", + "simultaneously", + "localization", + "crystallize", + "make", + "protein", + "study", + "activities", + "vitro", + "binding", + "together", + "multispecific", + "demonstrate", + "two", "confirm", - "constructs", + "connector", + "complex", + "flexibility", + "conformational", + "subcellular", + "formed", + "able", + "ideal", "us", - "use", - "compromising", - "selection", + "biological", + "rigid", + "helix", + "changing", + "bind", + "stability", + "exploiting", + "blocks", + "proteins", "modules", - "scaffolds", - "crystallography", - "designed", + "eight", + "use", + "multivalent", + "modular", + "ankyrin", + "units", + "bispecific", + "scaffold", + "restricting", "geometries", - "flexibility", - "target", + "design", + "joined", + "selection", + "binders", + "different", + "beyond", + "build", + "allows", + "building", + "method", + "darpins", "shared", - "join", - "bispecific", + "production", + "designed", + "one", + "way", + "avoiding", + "specificities", + "constructs", "based", + "darpin", + "without", + "predefined", "synthetic", - "bind", + "bringing", + "scaffolds", + "nine", "structure", - "repeat", - "able", - "building", - "without", - "allows", - "proteins", - "restricting", - "localization", - "rigid", - "binders", - "beyond", + "flexible", + "target", + "crystallography", "nature", - "vitro", - "production", - "units", - "individual", "capping", - "ease", - "molecules", - "joined", - "simultaneously", - "subcellular", - "stability", - "predefined", - "multivalent", + "yield", "linkers", - "activities", - "darpins", - "method", - "specificities", + "molecules", "gain", - "blocks", - "design", "high", - "bringing", - "repeats", - "biological", - "connector", - "inherent", - "make", - "demonstrate", - "eight", - "one", - "build", - "conformational", - "avoiding", - "study", - "flexible", - "way", - "together", - "modular", - "different", - "ankyrin", - "darpin", - "changing", - "affinities", - "two", - "exploiting", - "ideal", - "scaffold", - "protein", - "yield", - "complex", - "helix", - "nine", + "compromising", "distinct", - "multispecific", - "binding", - "formed", - "crystallize" + "affinities", + "join", + "inherent" ], "release_date":"2017-08-02", "publication":"\"Rigidly connected multispecific artificial binders with adjustable geometries\", Sci Rep, 7, 11217-11217", @@ -184725,7 +185191,7 @@ }, { "sim":610.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":610.0, @@ -184733,7 +185199,7 @@ }, { "sim":610.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":601.0, @@ -184813,47 +185279,47 @@ }, { "sim":255.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":255.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":255.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":255.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":255.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":255.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":255.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":255.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":255.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":255.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":255.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":255.0, @@ -184861,15 +185327,15 @@ }, { "sim":255.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":255.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":255.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":253.0, @@ -184909,15 +185375,15 @@ }, { "sim":244.0, - "partner":"7b4t" + "partner":"6fpb" }, { "sim":244.0, - "partner":"6fpb" + "partner":"6fpa" }, { "sim":244.0, - "partner":"6fpa" + "partner":"7b4t" }, { "sim":243.0, @@ -185009,11 +185475,11 @@ }, { "sim":184.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":184.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":181.0, @@ -185029,27 +185495,31 @@ }, { "sim":173.0, - "partner":"5kba" + "partner":"4gpm" }, { "sim":173.0, - "partner":"4gpm" + "partner":"5kba" }, { "sim":173.0, "partner":"4gmr" }, + { + "sim":171.0, + "partner":"9glq" + }, { "sim":169.0, "partner":"4hb5" }, { "sim":167.0, - "partner":"9f24" + "partner":"8aiw" }, { "sim":167.0, - "partner":"8aiw" + "partner":"9f24" }, { "sim":164.0, @@ -185141,10 +185611,6 @@ "sim":257.0, "partner":"4hna" }, - { - "sim":256.0, - "partner":"5eno" - }, { "sim":256.0, "partner":"4dx6" @@ -185213,6 +185679,10 @@ "sim":256.0, "partner":"4dx5" }, + { + "sim":256.0, + "partner":"5eno" + }, { "sim":255.0, "partner":"4lnu" @@ -185295,11 +185765,11 @@ }, { "sim":213.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":213.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":210.0, @@ -185523,15 +185993,15 @@ }, { "sim":111.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":111.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":111.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":111.0, @@ -185563,11 +186033,11 @@ }, { "sim":106.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":106.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":104.0, @@ -185631,11 +186101,11 @@ }, { "sim":94.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":94.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":93.0, @@ -185833,10 +186303,6 @@ "sim":68.0, "partner":"1oy3" }, - { - "sim":68.0, - "partner":"5iwr" - }, { "sim":68.0, "partner":"5iwt" @@ -185849,21 +186315,25 @@ "sim":68.0, "partner":"5iwp" }, + { + "sim":68.0, + "partner":"5iwr" + }, { "sim":66.0, "partner":"3ljn" }, { "sim":65.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":65.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":65.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":64.0, @@ -185925,6 +186395,10 @@ "sim":53.0, "partner":"4bet" }, + { + "sim":53.0, + "partner":"8ycp" + }, { "sim":51.0, "partner":"2pnn" @@ -186130,100 +186604,100 @@ ], "subtitle":"Crystal structure of darpin-darpin rigid fusion, variant dd_d12_15_d12", "tags":[ - "designed ankyrin repeat proteins; protein design; protein engineering; rigid domain fusions", - "de novo protein" + "de novo protein", + "designed ankyrin repeat proteins; protein design; protein engineering; rigid domain fusions" ], "keywords":[ + "repeats", + "individual", + "ease", + "repeat", + "simultaneously", + "localization", + "crystallize", + "make", + "protein", + "study", + "activities", + "vitro", + "binding", + "together", + "multispecific", + "demonstrate", + "two", "confirm", - "constructs", + "connector", + "complex", + "flexibility", + "conformational", + "subcellular", + "formed", + "able", + "ideal", "us", - "use", - "compromising", - "selection", + "biological", + "rigid", + "helix", + "changing", + "bind", + "stability", + "exploiting", + "blocks", + "proteins", "modules", - "scaffolds", - "crystallography", - "designed", + "eight", + "use", + "multivalent", + "modular", + "ankyrin", + "units", + "bispecific", + "scaffold", + "restricting", "geometries", - "flexibility", - "target", + "design", + "joined", + "selection", + "binders", + "different", + "beyond", + "build", + "allows", + "building", + "method", + "darpins", "shared", - "join", - "bispecific", + "production", + "designed", + "one", + "way", + "avoiding", + "specificities", + "constructs", "based", + "darpin", + "without", + "predefined", "synthetic", - "bind", + "bringing", + "scaffolds", + "nine", "structure", - "repeat", - "able", - "building", - "without", - "allows", - "proteins", - "restricting", - "localization", - "rigid", - "binders", - "beyond", + "flexible", + "target", + "crystallography", "nature", - "vitro", - "production", - "units", - "individual", "capping", - "ease", - "molecules", - "joined", - "simultaneously", - "subcellular", - "stability", - "predefined", - "multivalent", + "yield", "linkers", - "activities", - "darpins", - "method", - "specificities", + "molecules", "gain", - "blocks", - "design", "high", - "bringing", - "repeats", - "biological", - "connector", - "inherent", - "make", - "demonstrate", - "eight", - "one", - "build", - "conformational", - "avoiding", - "study", - "flexible", - "way", - "together", - "modular", - "different", - "ankyrin", - "darpin", - "changing", - "affinities", - "two", - "exploiting", - "ideal", - "scaffold", - "protein", - "yield", - "complex", - "helix", - "nine", + "compromising", "distinct", - "multispecific", - "binding", - "formed", - "crystallize" + "affinities", + "join", + "inherent" ], "release_date":"2017-08-02", "publication":"\"Rigidly connected multispecific artificial binders with adjustable geometries\", Sci Rep, 7, 11217-11217", @@ -186272,7 +186746,7 @@ }, { "sim":616.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":616.0, @@ -186280,7 +186754,7 @@ }, { "sim":616.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":613.0, @@ -186360,47 +186834,47 @@ }, { "sim":256.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":256.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":256.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":256.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":256.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":256.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":256.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":256.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":256.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":256.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":256.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":256.0, @@ -186408,15 +186882,15 @@ }, { "sim":256.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":256.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":256.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":256.0, @@ -186452,15 +186926,15 @@ }, { "sim":244.0, - "partner":"7b4t" + "partner":"6fpb" }, { "sim":244.0, - "partner":"6fpb" + "partner":"6fpa" }, { "sim":244.0, - "partner":"6fpa" + "partner":"7b4t" }, { "sim":243.0, @@ -186560,11 +187034,11 @@ }, { "sim":184.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":184.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":182.0, @@ -186584,11 +187058,15 @@ }, { "sim":173.0, - "partner":"5kba" + "partner":"4gpm" }, { "sim":173.0, - "partner":"4gpm" + "partner":"5kba" + }, + { + "sim":171.0, + "partner":"9glq" }, { "sim":170.0, @@ -186596,11 +187074,11 @@ }, { "sim":167.0, - "partner":"9f24" + "partner":"8aiw" }, { "sim":167.0, - "partner":"8aiw" + "partner":"9f24" }, { "sim":165.0, @@ -186688,10 +187166,6 @@ "sim":259.0, "partner":"4hna" }, - { - "sim":257.0, - "partner":"5eno" - }, { "sim":257.0, "partner":"4dx6" @@ -186760,6 +187234,10 @@ "sim":257.0, "partner":"4dx5" }, + { + "sim":257.0, + "partner":"5eno" + }, { "sim":256.0, "partner":"3zu7" @@ -186846,11 +187324,11 @@ }, { "sim":213.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":213.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":210.0, @@ -187082,15 +187560,15 @@ }, { "sim":109.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":109.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":109.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":109.0, @@ -187106,11 +187584,11 @@ }, { "sim":106.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":106.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":106.0, @@ -187174,11 +187652,11 @@ }, { "sim":94.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":94.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":93.0, @@ -187384,10 +187862,6 @@ "sim":68.0, "partner":"1oy3" }, - { - "sim":68.0, - "partner":"5iwr" - }, { "sim":68.0, "partner":"5iwt" @@ -187401,8 +187875,8 @@ "partner":"5iwp" }, { - "sim":65.0, - "partner":"2a5e" + "sim":68.0, + "partner":"5iwr" }, { "sim":65.0, @@ -187412,6 +187886,10 @@ "sim":65.0, "partner":"1a5e" }, + { + "sim":65.0, + "partner":"2a5e" + }, { "sim":64.0, "partner":"5d68" @@ -187476,6 +187954,10 @@ "sim":53.0, "partner":"4bet" }, + { + "sim":52.0, + "partner":"8ycp" + }, { "sim":51.0, "partner":"5an8" @@ -187697,103 +188179,103 @@ ], "subtitle":"Crystal structure of darpin-darpin rigid fusion, variant dd_off7_09_3g124", "tags":[ - "rigid domain fusions", "designed ankyrin repeat proteins", - "protein engineering", "de novo protein", + "rigid domain fusions", + "protein engineering", "protein design" ], "keywords":[ + "repeats", + "individual", + "ease", + "repeat", + "simultaneously", + "localization", + "crystallize", + "make", + "protein", + "study", + "activities", + "vitro", + "binding", + "together", + "multispecific", + "demonstrate", + "two", "confirm", - "constructs", + "connector", + "complex", + "flexibility", + "conformational", + "subcellular", + "formed", + "able", + "ideal", "us", - "use", - "compromising", - "selection", + "biological", + "rigid", + "helix", + "changing", + "bind", + "stability", + "exploiting", + "blocks", + "proteins", "modules", - "scaffolds", - "crystallography", - "designed", + "eight", + "use", + "multivalent", + "modular", + "ankyrin", + "units", + "bispecific", + "scaffold", + "restricting", "geometries", - "flexibility", - "target", + "design", + "joined", + "selection", + "binders", + "different", + "beyond", + "build", + "allows", + "building", + "method", + "darpins", "shared", - "join", - "bispecific", + "production", + "designed", + "one", + "way", + "avoiding", + "specificities", + "constructs", "based", + "darpin", + "without", + "predefined", "synthetic", - "bind", + "bringing", + "scaffolds", + "nine", "structure", - "repeat", - "able", - "building", - "without", - "allows", - "proteins", - "restricting", - "localization", - "rigid", - "binders", - "beyond", + "flexible", + "target", + "crystallography", "nature", - "vitro", - "production", - "units", - "individual", "capping", - "ease", - "molecules", - "joined", - "simultaneously", - "subcellular", - "stability", - "predefined", - "multivalent", + "yield", "linkers", - "activities", - "darpins", - "method", - "specificities", + "molecules", "gain", - "blocks", - "design", "high", - "bringing", - "repeats", - "biological", - "connector", - "inherent", - "make", - "demonstrate", - "eight", - "one", - "build", - "conformational", - "avoiding", - "study", - "flexible", - "way", - "together", - "modular", - "different", - "ankyrin", - "darpin", - "changing", - "affinities", - "two", - "exploiting", - "ideal", - "scaffold", - "protein", - "yield", - "complex", - "helix", - "nine", + "compromising", "distinct", - "multispecific", - "binding", - "formed", - "crystallize" + "affinities", + "join", + "inherent" ], "release_date":"2017-08-02", "publication":"\"Rigidly connected multispecific artificial binders with adjustable geometries\", Sci Rep, 7, 11217-11217", @@ -187858,7 +188340,7 @@ }, { "sim":486.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":486.0, @@ -187866,7 +188348,7 @@ }, { "sim":486.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":331.0, @@ -187886,11 +188368,11 @@ }, { "sim":268.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":268.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":266.0, @@ -187902,11 +188384,11 @@ }, { "sim":264.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":264.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":263.0, @@ -187922,11 +188404,11 @@ }, { "sim":263.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":263.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":263.0, @@ -187934,19 +188416,19 @@ }, { "sim":262.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":262.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":262.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":262.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":262.0, @@ -187954,35 +188436,35 @@ }, { "sim":262.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":262.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":262.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":262.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":262.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":262.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":262.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":262.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":261.0, @@ -188134,11 +188616,11 @@ }, { "sim":184.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":184.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":182.0, @@ -188164,6 +188646,10 @@ "sim":177.0, "partner":"4hb5" }, + { + "sim":176.0, + "partner":"9glq" + }, { "sim":174.0, "partner":"9f24" @@ -188234,10 +188720,6 @@ "sim":269.0, "partner":"4hrm" }, - { - "sim":265.0, - "partner":"5eno" - }, { "sim":265.0, "partner":"4dx6" @@ -188322,6 +188804,10 @@ "sim":265.0, "partner":"4dx5" }, + { + "sim":265.0, + "partner":"5eno" + }, { "sim":265.0, "partner":"5aqb" @@ -188420,11 +188906,11 @@ }, { "sim":216.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":216.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":214.0, @@ -188620,15 +189106,15 @@ }, { "sim":118.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":118.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":118.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":115.0, @@ -188680,11 +189166,11 @@ }, { "sim":105.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":105.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":105.0, @@ -188728,11 +189214,11 @@ }, { "sim":100.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":100.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":100.0, @@ -188882,10 +189368,6 @@ "sim":83.0, "partner":"1oy3" }, - { - "sim":82.0, - "partner":"5iwr" - }, { "sim":82.0, "partner":"5iwt" @@ -188898,6 +189380,10 @@ "sim":82.0, "partner":"5iwp" }, + { + "sim":82.0, + "partner":"5iwr" + }, { "sim":80.0, "partner":"1ymp" @@ -188982,6 +189468,10 @@ "sim":66.0, "partner":"8pef" }, + { + "sim":64.0, + "partner":"8ycp" + }, { "sim":61.0, "partner":"2pnn" @@ -189153,103 +189643,103 @@ ], "subtitle":"Crystal structure of darpin-darpin rigid fusion, variant dd_off7_12_3g124", "tags":[ - "rigid domain fusions", "designed ankyrin repeat proteins", - "protein engineering", "de novo protein", + "rigid domain fusions", + "protein engineering", "protein design" ], "keywords":[ + "repeats", + "individual", + "ease", + "repeat", + "simultaneously", + "localization", + "crystallize", + "make", + "protein", + "study", + "activities", + "vitro", + "binding", + "together", + "multispecific", + "demonstrate", + "two", "confirm", - "constructs", + "connector", + "complex", + "flexibility", + "conformational", + "subcellular", + "formed", + "able", + "ideal", "us", - "use", - "compromising", - "selection", + "biological", + "rigid", + "helix", + "changing", + "bind", + "stability", + "exploiting", + "blocks", + "proteins", "modules", - "scaffolds", - "crystallography", - "designed", + "eight", + "use", + "multivalent", + "modular", + "ankyrin", + "units", + "bispecific", + "scaffold", + "restricting", "geometries", - "flexibility", - "target", + "design", + "joined", + "selection", + "binders", + "different", + "beyond", + "build", + "allows", + "building", + "method", + "darpins", "shared", - "join", - "bispecific", + "production", + "designed", + "one", + "way", + "avoiding", + "specificities", + "constructs", "based", + "darpin", + "without", + "predefined", "synthetic", - "bind", + "bringing", + "scaffolds", + "nine", "structure", - "repeat", - "able", - "building", - "without", - "allows", - "proteins", - "restricting", - "localization", - "rigid", - "binders", - "beyond", + "flexible", + "target", + "crystallography", "nature", - "vitro", - "production", - "units", - "individual", "capping", - "ease", - "molecules", - "joined", - "simultaneously", - "subcellular", - "stability", - "predefined", - "multivalent", + "yield", "linkers", - "activities", - "darpins", - "method", - "specificities", + "molecules", "gain", - "blocks", - "design", "high", - "bringing", - "repeats", - "biological", - "connector", - "inherent", - "make", - "demonstrate", - "eight", - "one", - "build", - "conformational", - "avoiding", - "study", - "flexible", - "way", - "together", - "modular", - "different", - "ankyrin", - "darpin", - "changing", - "affinities", - "two", - "exploiting", - "ideal", - "scaffold", - "protein", - "yield", - "complex", - "helix", - "nine", + "compromising", "distinct", - "multispecific", - "binding", - "formed", - "crystallize" + "affinities", + "join", + "inherent" ], "release_date":"2017-08-02", "publication":"\"Rigidly connected multispecific artificial binders with adjustable geometries\", Sci Rep, 7, 11217-11217", @@ -189290,7 +189780,7 @@ }, { "sim":526.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":526.0, @@ -189298,7 +189788,7 @@ }, { "sim":526.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":522.0, @@ -189342,11 +189832,11 @@ }, { "sim":268.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":268.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":266.0, @@ -189362,11 +189852,11 @@ }, { "sim":265.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":265.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":265.0, @@ -189374,11 +189864,11 @@ }, { "sim":264.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":264.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":264.0, @@ -189394,19 +189884,19 @@ }, { "sim":262.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":262.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":262.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":262.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":262.0, @@ -189414,35 +189904,35 @@ }, { "sim":262.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":262.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":262.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":262.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":262.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":262.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":262.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":262.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":262.0, @@ -189538,11 +190028,11 @@ }, { "sim":233.0, - "partner":"7dne" + "partner":"2xeh" }, { "sim":233.0, - "partner":"2xeh" + "partner":"7dne" }, { "sim":231.0, @@ -189586,11 +190076,11 @@ }, { "sim":187.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":187.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":185.0, @@ -189624,6 +190114,10 @@ "sim":176.0, "partner":"9f24" }, + { + "sim":176.0, + "partner":"9glq" + }, { "sim":175.0, "partner":"4hb5" @@ -189694,10 +190188,6 @@ "sim":266.0, "partner":"5aqb" }, - { - "sim":265.0, - "partner":"5eno" - }, { "sim":265.0, "partner":"4dx6" @@ -189782,6 +190272,10 @@ "sim":265.0, "partner":"4dx5" }, + { + "sim":265.0, + "partner":"5eno" + }, { "sim":263.0, "partner":"4ydy" @@ -189884,11 +190378,11 @@ }, { "sim":214.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":214.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":211.0, @@ -190036,15 +190530,15 @@ }, { "sim":123.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":123.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":123.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":122.0, @@ -190128,11 +190622,11 @@ }, { "sim":105.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":105.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":103.0, @@ -190184,11 +190678,11 @@ }, { "sim":100.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":100.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":100.0, @@ -190326,10 +190820,6 @@ "sim":81.0, "partner":"1wg0" }, - { - "sim":81.0, - "partner":"5iwr" - }, { "sim":81.0, "partner":"5iwt" @@ -190342,6 +190832,10 @@ "sim":81.0, "partner":"5iwp" }, + { + "sim":81.0, + "partner":"5iwr" + }, { "sim":80.0, "partner":"1ymp" @@ -190388,15 +190882,15 @@ }, { "sim":73.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":73.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":73.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":72.0, @@ -190486,6 +190980,10 @@ "sim":60.0, "partner":"5is0" }, + { + "sim":60.0, + "partner":"8ycp" + }, { "sim":59.0, "partner":"3deo" @@ -190619,103 +191117,103 @@ ], "subtitle":"Crystal structure of darpin-darpin rigid fusion, variant ddd_d12_06_d12_06_d12", "tags":[ - "rigid domain fusions", "designed ankyrin repeat proteins", - "protein engineering", "de novo protein", + "rigid domain fusions", + "protein engineering", "protein design" ], "keywords":[ + "repeats", + "individual", + "ease", + "repeat", + "simultaneously", + "localization", + "crystallize", + "make", + "protein", + "study", + "activities", + "vitro", + "binding", + "together", + "multispecific", + "demonstrate", + "two", "confirm", - "constructs", + "connector", + "complex", + "flexibility", + "conformational", + "subcellular", + "formed", + "able", + "ideal", "us", - "use", - "compromising", - "selection", + "biological", + "rigid", + "helix", + "changing", + "bind", + "stability", + "exploiting", + "blocks", + "proteins", "modules", - "scaffolds", - "crystallography", - "designed", + "eight", + "use", + "multivalent", + "modular", + "ankyrin", + "units", + "bispecific", + "scaffold", + "restricting", "geometries", - "flexibility", - "target", + "design", + "joined", + "selection", + "binders", + "different", + "beyond", + "build", + "allows", + "building", + "method", + "darpins", "shared", - "join", - "bispecific", + "production", + "designed", + "one", + "way", + "avoiding", + "specificities", + "constructs", "based", + "darpin", + "without", + "predefined", "synthetic", - "bind", + "bringing", + "scaffolds", + "nine", "structure", - "repeat", - "able", - "building", - "without", - "allows", - "proteins", - "restricting", - "localization", - "rigid", - "binders", - "beyond", + "flexible", + "target", + "crystallography", "nature", - "vitro", - "production", - "units", - "individual", "capping", - "ease", - "molecules", - "joined", - "simultaneously", - "subcellular", - "stability", - "predefined", - "multivalent", + "yield", "linkers", - "activities", - "darpins", - "method", - "specificities", + "molecules", "gain", - "blocks", - "design", "high", - "bringing", - "repeats", - "biological", - "connector", - "inherent", - "make", - "demonstrate", - "eight", - "one", - "build", - "conformational", - "avoiding", - "study", - "flexible", - "way", - "together", - "modular", - "different", - "ankyrin", - "darpin", - "changing", - "affinities", - "two", - "exploiting", - "ideal", - "scaffold", - "protein", - "yield", - "complex", - "helix", - "nine", + "compromising", "distinct", - "multispecific", - "binding", - "formed", - "crystallize" + "affinities", + "join", + "inherent" ], "release_date":"2017-08-02", "publication":"\"Rigidly connected multispecific artificial binders with adjustable geometries\", Sci Rep, 7, 11217-11217", @@ -190752,7 +191250,7 @@ }, { "sim":877.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":877.0, @@ -190760,7 +191258,7 @@ }, { "sim":877.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":612.0, @@ -190852,47 +191350,47 @@ }, { "sim":256.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":256.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":256.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":256.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":256.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":256.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":256.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":256.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":256.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":256.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":256.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":256.0, @@ -190900,15 +191398,15 @@ }, { "sim":256.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":256.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":256.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":255.0, @@ -191052,11 +191550,11 @@ }, { "sim":184.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":184.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":180.0, @@ -191078,6 +191576,10 @@ "sim":172.0, "partner":"4gmr" }, + { + "sim":171.0, + "partner":"9glq" + }, { "sim":170.0, "partner":"4gpm" @@ -191192,10 +191694,6 @@ "sim":259.0, "partner":"4hna" }, - { - "sim":257.0, - "partner":"5eno" - }, { "sim":257.0, "partner":"4dx6" @@ -191264,6 +191762,10 @@ "sim":257.0, "partner":"4dx5" }, + { + "sim":257.0, + "partner":"5eno" + }, { "sim":257.0, "partner":"5aqa" @@ -191354,11 +191856,11 @@ }, { "sim":213.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":213.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":207.0, @@ -191546,11 +192048,11 @@ }, { "sim":110.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":110.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":108.0, @@ -191622,11 +192124,11 @@ }, { "sim":99.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":99.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":99.0, @@ -191856,10 +192358,6 @@ "sim":68.0, "partner":"1bi7" }, - { - "sim":68.0, - "partner":"5iwr" - }, { "sim":68.0, "partner":"5iwt" @@ -191872,21 +192370,25 @@ "sim":68.0, "partner":"5iwp" }, + { + "sim":68.0, + "partner":"5iwr" + }, { "sim":66.0, "partner":"4a63" }, { "sim":65.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":65.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":65.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":65.0, @@ -191912,6 +192414,10 @@ "sim":57.0, "partner":"2vge" }, + { + "sim":57.0, + "partner":"8ycp" + }, { "sim":55.0, "partner":"5u0i" @@ -192078,103 +192584,103 @@ ], "subtitle":"Crystal structure of darpin-darpin rigid fusion, variant ddd_d12_12_d12_12_d12", "tags":[ - "rigid domain fusions", "designed ankyrin repeat proteins", - "protein engineering", "de novo protein", + "rigid domain fusions", + "protein engineering", "protein design" ], "keywords":[ + "repeats", + "individual", + "ease", + "repeat", + "simultaneously", + "localization", + "crystallize", + "make", + "protein", + "study", + "activities", + "vitro", + "binding", + "together", + "multispecific", + "demonstrate", + "two", "confirm", - "constructs", + "connector", + "complex", + "flexibility", + "conformational", + "subcellular", + "formed", + "able", + "ideal", "us", - "use", - "compromising", - "selection", + "biological", + "rigid", + "helix", + "changing", + "bind", + "stability", + "exploiting", + "blocks", + "proteins", "modules", - "scaffolds", - "crystallography", - "designed", + "eight", + "use", + "multivalent", + "modular", + "ankyrin", + "units", + "bispecific", + "scaffold", + "restricting", "geometries", - "flexibility", - "target", + "design", + "joined", + "selection", + "binders", + "different", + "beyond", + "build", + "allows", + "building", + "method", + "darpins", "shared", - "join", - "bispecific", + "production", + "designed", + "one", + "way", + "avoiding", + "specificities", + "constructs", "based", + "darpin", + "without", + "predefined", "synthetic", - "bind", + "bringing", + "scaffolds", + "nine", "structure", - "repeat", - "able", - "building", - "without", - "allows", - "proteins", - "restricting", - "localization", - "rigid", - "binders", - "beyond", + "flexible", + "target", + "crystallography", "nature", - "vitro", - "production", - "units", - "individual", "capping", - "ease", - "molecules", - "joined", - "simultaneously", - "subcellular", - "stability", - "predefined", - "multivalent", + "yield", "linkers", - "activities", - "darpins", - "method", - "specificities", + "molecules", "gain", - "blocks", - "design", "high", - "bringing", - "repeats", - "biological", - "connector", - "inherent", - "make", - "demonstrate", - "eight", - "one", - "build", - "conformational", - "avoiding", - "study", - "flexible", - "way", - "together", - "modular", - "different", - "ankyrin", - "darpin", - "changing", - "affinities", - "two", - "exploiting", - "ideal", - "scaffold", - "protein", - "yield", - "complex", - "helix", - "nine", + "compromising", "distinct", - "multispecific", - "binding", - "formed", - "crystallize" + "affinities", + "join", + "inherent" ], "release_date":"2017-08-02", "publication":"\"Rigidly connected multispecific artificial binders with adjustable geometries\", Sci Rep, 7, 11217-11217", @@ -192207,11 +192713,11 @@ "seq_thr_sim_designed":[ { "sim":985.0, - "partner":"5led" + "partner":"5lee" }, { "sim":985.0, - "partner":"5lee" + "partner":"5led" }, { "sim":934.0, @@ -192311,47 +192817,47 @@ }, { "sim":252.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":252.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":252.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":252.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":252.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":252.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":252.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":252.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":252.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":252.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":252.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":252.0, @@ -192359,15 +192865,15 @@ }, { "sim":252.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":252.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":252.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":252.0, @@ -192515,16 +193021,20 @@ }, { "sim":179.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":179.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":177.0, "partner":"4hqd" }, + { + "sim":171.0, + "partner":"9glq" + }, { "sim":171.0, "partner":"9f23" @@ -192543,11 +193053,11 @@ }, { "sim":167.0, - "partner":"9f24" + "partner":"8aiw" }, { "sim":167.0, - "partner":"8aiw" + "partner":"9f24" }, { "sim":166.0, @@ -192651,10 +193161,6 @@ "sim":254.0, "partner":"4hna" }, - { - "sim":252.0, - "partner":"5eno" - }, { "sim":252.0, "partner":"4dx6" @@ -192731,6 +193237,10 @@ "sim":252.0, "partner":"4dx5" }, + { + "sim":252.0, + "partner":"5eno" + }, { "sim":251.0, "partner":"3zu7" @@ -192813,11 +193323,11 @@ }, { "sim":207.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":207.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":205.0, @@ -193005,15 +193515,15 @@ }, { "sim":116.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":116.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":116.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":114.0, @@ -193045,11 +193555,11 @@ }, { "sim":106.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":106.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":106.0, @@ -193109,11 +193619,11 @@ }, { "sim":96.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":96.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":95.0, @@ -193327,10 +193837,6 @@ "sim":68.0, "partner":"5cer" }, - { - "sim":68.0, - "partner":"5iwr" - }, { "sim":68.0, "partner":"5iwt" @@ -193343,6 +193849,10 @@ "sim":68.0, "partner":"5iwp" }, + { + "sim":68.0, + "partner":"5iwr" + }, { "sim":66.0, "partner":"1k3z" @@ -193353,15 +193863,15 @@ }, { "sim":65.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":65.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":65.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":64.0, @@ -193466,6 +193976,10 @@ { "sim":53.0, "partner":"4bet" + }, + { + "sim":53.0, + "partner":"8ycp" } ], "struct_thr_sim_designed":[ @@ -193483,7 +193997,7 @@ ], "seq_max_sim_designed":{ "sim":985.0, - "partner":"5led" + "partner":"5lee" }, "seq_max_sim_natural":{ "sim":492.0, @@ -193549,103 +194063,103 @@ ], "subtitle":"Crystal structure of darpin-darpin rigid fusion, variant ddd_d12_12_d12_12_d12", "tags":[ - "rigid domain fusions", "designed ankyrin repeat proteins", - "protein engineering", "de novo protein", + "rigid domain fusions", + "protein engineering", "protein design" ], "keywords":[ + "repeats", + "individual", + "ease", + "repeat", + "simultaneously", + "localization", + "crystallize", + "make", + "protein", + "study", + "activities", + "vitro", + "binding", + "together", + "multispecific", + "demonstrate", + "two", "confirm", - "constructs", + "connector", + "complex", + "flexibility", + "conformational", + "subcellular", + "formed", + "able", + "ideal", "us", - "use", - "compromising", - "selection", + "biological", + "rigid", + "helix", + "changing", + "bind", + "stability", + "exploiting", + "blocks", + "proteins", "modules", - "scaffolds", - "crystallography", - "designed", + "eight", + "use", + "multivalent", + "modular", + "ankyrin", + "units", + "bispecific", + "scaffold", + "restricting", "geometries", - "flexibility", - "target", + "design", + "joined", + "selection", + "binders", + "different", + "beyond", + "build", + "allows", + "building", + "method", + "darpins", "shared", - "join", - "bispecific", + "production", + "designed", + "one", + "way", + "avoiding", + "specificities", + "constructs", "based", + "darpin", + "without", + "predefined", "synthetic", - "bind", + "bringing", + "scaffolds", + "nine", "structure", - "repeat", - "able", - "building", - "without", - "allows", - "proteins", - "restricting", - "localization", - "rigid", - "binders", - "beyond", + "flexible", + "target", + "crystallography", "nature", - "vitro", - "production", - "units", - "individual", "capping", - "ease", - "molecules", - "joined", - "simultaneously", - "subcellular", - "stability", - "predefined", - "multivalent", + "yield", "linkers", - "activities", - "darpins", - "method", - "specificities", + "molecules", "gain", - "blocks", - "design", "high", - "bringing", - "repeats", - "biological", - "connector", - "inherent", - "make", - "demonstrate", - "eight", - "one", - "build", - "conformational", - "avoiding", - "study", - "flexible", - "way", - "together", - "modular", - "different", - "ankyrin", - "darpin", - "changing", - "affinities", - "two", - "exploiting", - "ideal", - "scaffold", - "protein", - "yield", - "complex", - "helix", - "nine", + "compromising", "distinct", - "multispecific", - "binding", - "formed", - "crystallize" + "affinities", + "join", + "inherent" ], "release_date":"2017-08-02", "publication":"\"Rigidly connected multispecific artificial binders with adjustable geometries\", Sci Rep, 7, 11217-11217", @@ -193678,11 +194192,11 @@ "seq_thr_sim_designed":[ { "sim":985.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":985.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":934.0, @@ -193782,47 +194296,47 @@ }, { "sim":252.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":252.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":252.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":252.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":252.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":252.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":252.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":252.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":252.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":252.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":252.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":252.0, @@ -193830,15 +194344,15 @@ }, { "sim":252.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":252.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":252.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":252.0, @@ -193986,16 +194500,20 @@ }, { "sim":179.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":179.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":177.0, "partner":"4hqd" }, + { + "sim":171.0, + "partner":"9glq" + }, { "sim":171.0, "partner":"9f23" @@ -194014,11 +194532,11 @@ }, { "sim":167.0, - "partner":"9f24" + "partner":"8aiw" }, { "sim":167.0, - "partner":"8aiw" + "partner":"9f24" }, { "sim":166.0, @@ -194122,10 +194640,6 @@ "sim":254.0, "partner":"4hna" }, - { - "sim":252.0, - "partner":"5eno" - }, { "sim":252.0, "partner":"4dx6" @@ -194202,6 +194716,10 @@ "sim":252.0, "partner":"4dx5" }, + { + "sim":252.0, + "partner":"5eno" + }, { "sim":251.0, "partner":"3zu7" @@ -194284,11 +194802,11 @@ }, { "sim":207.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":207.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":205.0, @@ -194476,15 +194994,15 @@ }, { "sim":116.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":116.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":116.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":114.0, @@ -194516,11 +195034,11 @@ }, { "sim":106.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":106.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":106.0, @@ -194580,11 +195098,11 @@ }, { "sim":96.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":96.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":95.0, @@ -194798,10 +195316,6 @@ "sim":68.0, "partner":"5cer" }, - { - "sim":68.0, - "partner":"5iwr" - }, { "sim":68.0, "partner":"5iwt" @@ -194814,6 +195328,10 @@ "sim":68.0, "partner":"5iwp" }, + { + "sim":68.0, + "partner":"5iwr" + }, { "sim":66.0, "partner":"1k3z" @@ -194824,15 +195342,15 @@ }, { "sim":65.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":65.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":65.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":64.0, @@ -194937,6 +195455,10 @@ { "sim":53.0, "partner":"4bet" + }, + { + "sim":53.0, + "partner":"8ycp" } ], "struct_thr_sim_designed":[ @@ -194954,7 +195476,7 @@ ], "seq_max_sim_designed":{ "sim":985.0, - "partner":"5lec" + "partner":"5lee" }, "seq_max_sim_natural":{ "sim":492.0, @@ -195020,103 +195542,103 @@ ], "subtitle":"Crystal structure of darpin-darpin rigid fusion, variant ddd_d12_12_d12_12_d12", "tags":[ - "rigid domain fusions", "designed ankyrin repeat proteins", - "protein engineering", "de novo protein", + "rigid domain fusions", + "protein engineering", "protein design" ], "keywords":[ + "repeats", + "individual", + "ease", + "repeat", + "simultaneously", + "localization", + "crystallize", + "make", + "protein", + "study", + "activities", + "vitro", + "binding", + "together", + "multispecific", + "demonstrate", + "two", "confirm", - "constructs", + "connector", + "complex", + "flexibility", + "conformational", + "subcellular", + "formed", + "able", + "ideal", "us", - "use", - "compromising", - "selection", + "biological", + "rigid", + "helix", + "changing", + "bind", + "stability", + "exploiting", + "blocks", + "proteins", "modules", - "scaffolds", - "crystallography", - "designed", + "eight", + "use", + "multivalent", + "modular", + "ankyrin", + "units", + "bispecific", + "scaffold", + "restricting", "geometries", - "flexibility", - "target", + "design", + "joined", + "selection", + "binders", + "different", + "beyond", + "build", + "allows", + "building", + "method", + "darpins", "shared", - "join", - "bispecific", + "production", + "designed", + "one", + "way", + "avoiding", + "specificities", + "constructs", "based", + "darpin", + "without", + "predefined", "synthetic", - "bind", + "bringing", + "scaffolds", + "nine", "structure", - "repeat", - "able", - "building", - "without", - "allows", - "proteins", - "restricting", - "localization", - "rigid", - "binders", - "beyond", + "flexible", + "target", + "crystallography", "nature", - "vitro", - "production", - "units", - "individual", "capping", - "ease", - "molecules", - "joined", - "simultaneously", - "subcellular", - "stability", - "predefined", - "multivalent", + "yield", "linkers", - "activities", - "darpins", - "method", - "specificities", + "molecules", "gain", - "blocks", - "design", "high", - "bringing", - "repeats", - "biological", - "connector", - "inherent", - "make", - "demonstrate", - "eight", - "one", - "build", - "conformational", - "avoiding", - "study", - "flexible", - "way", - "together", - "modular", - "different", - "ankyrin", - "darpin", - "changing", - "affinities", - "two", - "exploiting", - "ideal", - "scaffold", - "protein", - "yield", - "complex", - "helix", - "nine", + "compromising", "distinct", - "multispecific", - "binding", - "formed", - "crystallize" + "affinities", + "join", + "inherent" ], "release_date":"2017-08-02", "publication":"\"Rigidly connected multispecific artificial binders with adjustable geometries\", Sci Rep, 7, 11217-11217", @@ -195149,11 +195671,11 @@ "seq_thr_sim_designed":[ { "sim":985.0, - "partner":"5lec" + "partner":"5led" }, { "sim":985.0, - "partner":"5led" + "partner":"5lec" }, { "sim":934.0, @@ -195253,47 +195775,47 @@ }, { "sim":252.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":252.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":252.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":252.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":252.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":252.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":252.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":252.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":252.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":252.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":252.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":252.0, @@ -195301,15 +195823,15 @@ }, { "sim":252.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":252.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":252.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":252.0, @@ -195457,16 +195979,20 @@ }, { "sim":179.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":179.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":177.0, "partner":"4hqd" }, + { + "sim":171.0, + "partner":"9glq" + }, { "sim":171.0, "partner":"9f23" @@ -195485,11 +196011,11 @@ }, { "sim":167.0, - "partner":"9f24" + "partner":"8aiw" }, { "sim":167.0, - "partner":"8aiw" + "partner":"9f24" }, { "sim":166.0, @@ -195593,10 +196119,6 @@ "sim":254.0, "partner":"4hna" }, - { - "sim":252.0, - "partner":"5eno" - }, { "sim":252.0, "partner":"4dx6" @@ -195673,6 +196195,10 @@ "sim":252.0, "partner":"4dx5" }, + { + "sim":252.0, + "partner":"5eno" + }, { "sim":251.0, "partner":"3zu7" @@ -195755,11 +196281,11 @@ }, { "sim":207.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":207.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":205.0, @@ -195947,15 +196473,15 @@ }, { "sim":116.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":116.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":116.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":114.0, @@ -195987,11 +196513,11 @@ }, { "sim":106.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":106.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":106.0, @@ -196051,11 +196577,11 @@ }, { "sim":96.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":96.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":95.0, @@ -196269,10 +196795,6 @@ "sim":68.0, "partner":"5cer" }, - { - "sim":68.0, - "partner":"5iwr" - }, { "sim":68.0, "partner":"5iwt" @@ -196285,6 +196807,10 @@ "sim":68.0, "partner":"5iwp" }, + { + "sim":68.0, + "partner":"5iwr" + }, { "sim":66.0, "partner":"1k3z" @@ -196295,15 +196821,15 @@ }, { "sim":65.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":65.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":65.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":64.0, @@ -196408,6 +196934,10 @@ { "sim":53.0, "partner":"4bet" + }, + { + "sim":53.0, + "partner":"8ycp" } ], "struct_thr_sim_designed":[ @@ -196421,7 +196951,7 @@ ], "seq_max_sim_designed":{ "sim":985.0, - "partner":"5lec" + "partner":"5led" }, "seq_max_sim_natural":{ "sim":492.0, @@ -196503,76 +197033,76 @@ "structural protein" ], "keywords":[ - "stability", - "buttressed", - "unfolding", - "chains", - "monomeric", - "hydroxyl", - "substituting", - "groups", - "analyses", - "reduces", - "observe", - "complexes", - "similar", + "reveal", + "designed", + "polyproline", + "miniproteins", + "cooperatively", + "aromatic", + "probe", "phenylalanine", - "temperature", - "sh3", - "rings", - "peptide", - "allowing", + "39", "pp\u03b1", - "abundant", - "designed", - "biologically", + "observe", + "soluble", + "structures", + "complexes", + "natural", + "dissection", + "side", + "hydroxyl", + "three", + "unfolds", + "residues", + "important", + "monomeric", + "helix", + "tyrosine", + "replacing", + "ligands", "sensitive", + "groups", "attribute", - "residues", - "reveal", + "temperature", + "loss", + "nmr", "changing", - "unfolds", - "midpoint", - "preference", - "problem", + "protein", + "interactions", + "biologically", + "substituting", + "stability", + "20", + "reduces", "modifications", - "dissection", - "result", - "stabilize", - "replacing", - "ii", - "tyrosine", + "nonproteinogenic", + "comprising", + "forces", + "midpoint", + "unfolding", "find", "domains", + "abundant", "simplify", - "structures", - "protein", - "soluble", - "interactions", - "probe", - "nmr", - "nonproteinogenic", - "loss", - "describe", - "water", - "helix", - "proline", + "result", "docked", - "three", - "natural", - "pairs", + "sh3", + "proline", + "buttressed", + "rings", + "ii", + "problem", + "preference", + "stabilize", + "describe", + "chains", + "analyses", + "similar", + "allowing", "protons", - "39", - "ligands", - "comprising", - "20", - "side", - "polyproline", - "cooperatively", - "important", - "forces", - "aromatic", - "miniproteins" + "pairs", + "peptide", + "water" ], "release_date":"2017-05-17", "publication":"\"Engineering protein stability with atomic precision in a monomeric miniprotein\", Nat. Chem. Biol., 13, 764-770", @@ -196694,76 +197224,76 @@ "structural protein" ], "keywords":[ - "stability", - "buttressed", - "unfolding", - "chains", - "monomeric", - "hydroxyl", - "substituting", - "groups", - "analyses", - "reduces", - "observe", - "complexes", - "similar", + "reveal", + "designed", + "polyproline", + "miniproteins", + "cooperatively", + "aromatic", + "probe", "phenylalanine", - "temperature", - "sh3", - "rings", - "peptide", - "allowing", + "39", "pp\u03b1", - "abundant", - "designed", - "biologically", + "observe", + "soluble", + "structures", + "complexes", + "natural", + "dissection", + "side", + "hydroxyl", + "three", + "unfolds", + "residues", + "important", + "monomeric", + "helix", + "tyrosine", + "replacing", + "ligands", "sensitive", + "groups", "attribute", - "residues", - "reveal", + "temperature", + "loss", + "nmr", "changing", - "unfolds", - "midpoint", - "preference", - "problem", + "protein", + "interactions", + "biologically", + "substituting", + "stability", + "20", + "reduces", "modifications", - "dissection", - "result", - "stabilize", - "replacing", - "ii", - "tyrosine", + "nonproteinogenic", + "comprising", + "forces", + "midpoint", + "unfolding", "find", "domains", + "abundant", "simplify", - "structures", - "protein", - "soluble", - "interactions", - "probe", - "nmr", - "nonproteinogenic", - "loss", - "describe", - "water", - "helix", - "proline", + "result", "docked", - "three", - "natural", - "pairs", + "sh3", + "proline", + "buttressed", + "rings", + "ii", + "problem", + "preference", + "stabilize", + "describe", + "chains", + "analyses", + "similar", + "allowing", "protons", - "39", - "ligands", - "comprising", - "20", - "side", - "polyproline", - "cooperatively", - "important", - "forces", - "aromatic", - "miniproteins" + "pairs", + "peptide", + "water" ], "release_date":"2017-05-17", "publication":"\"Engineering protein stability with atomic precision in a monomeric miniprotein\", Nat. Chem. Biol., 13, 764-770", @@ -196885,76 +197415,76 @@ "structural protein" ], "keywords":[ - "stability", - "buttressed", - "unfolding", - "chains", - "monomeric", - "hydroxyl", - "substituting", - "groups", - "analyses", - "reduces", - "observe", - "complexes", - "similar", + "reveal", + "designed", + "polyproline", + "miniproteins", + "cooperatively", + "aromatic", + "probe", "phenylalanine", - "temperature", - "sh3", - "rings", - "peptide", - "allowing", + "39", "pp\u03b1", - "abundant", - "designed", - "biologically", + "observe", + "soluble", + "structures", + "complexes", + "natural", + "dissection", + "side", + "hydroxyl", + "three", + "unfolds", + "residues", + "important", + "monomeric", + "helix", + "tyrosine", + "replacing", + "ligands", "sensitive", + "groups", "attribute", - "residues", - "reveal", + "temperature", + "loss", + "nmr", "changing", - "unfolds", - "midpoint", - "preference", - "problem", + "protein", + "interactions", + "biologically", + "substituting", + "stability", + "20", + "reduces", "modifications", - "dissection", - "result", - "stabilize", - "replacing", - "ii", - "tyrosine", + "nonproteinogenic", + "comprising", + "forces", + "midpoint", + "unfolding", "find", "domains", + "abundant", "simplify", - "structures", - "protein", - "soluble", - "interactions", - "probe", - "nmr", - "nonproteinogenic", - "loss", - "describe", - "water", - "helix", - "proline", + "result", "docked", - "three", - "natural", - "pairs", + "sh3", + "proline", + "buttressed", + "rings", + "ii", + "problem", + "preference", + "stabilize", + "describe", + "chains", + "analyses", + "similar", + "allowing", "protons", - "39", - "ligands", - "comprising", - "20", - "side", - "polyproline", - "cooperatively", - "important", - "forces", - "aromatic", - "miniproteins" + "pairs", + "peptide", + "water" ], "release_date":"2017-05-17", "publication":"\"Engineering protein stability with atomic precision in a monomeric miniprotein\", Nat. Chem. Biol., 13, 764-770", @@ -197060,103 +197590,103 @@ ], "subtitle":"Crystal structure of darpin 5m3_d12", "tags":[ - "rigid domain fusions", "designed ankyrin repeat proteins", - "protein engineering", "de novo protein", + "rigid domain fusions", + "protein engineering", "protein design" ], "keywords":[ + "repeats", + "individual", + "ease", + "repeat", + "simultaneously", + "localization", + "crystallize", + "make", + "protein", + "study", + "activities", + "vitro", + "binding", + "together", + "multispecific", + "demonstrate", + "two", "confirm", - "constructs", + "connector", + "complex", + "flexibility", + "conformational", + "subcellular", + "formed", + "able", + "ideal", "us", - "use", - "compromising", - "selection", + "biological", + "rigid", + "helix", + "changing", + "bind", + "stability", + "exploiting", + "blocks", + "proteins", "modules", - "scaffolds", - "crystallography", - "designed", + "eight", + "use", + "multivalent", + "modular", + "ankyrin", + "units", + "bispecific", + "scaffold", + "restricting", "geometries", - "flexibility", - "target", + "design", + "joined", + "selection", + "binders", + "different", + "beyond", + "build", + "allows", + "building", + "method", + "darpins", "shared", - "join", - "bispecific", + "production", + "designed", + "one", + "way", + "avoiding", + "specificities", + "constructs", "based", + "darpin", + "without", + "predefined", "synthetic", - "bind", + "bringing", + "scaffolds", + "nine", "structure", - "repeat", - "able", - "building", - "without", - "allows", - "proteins", - "restricting", - "localization", - "rigid", - "binders", - "beyond", + "flexible", + "target", + "crystallography", "nature", - "vitro", - "production", - "units", - "individual", "capping", - "ease", - "molecules", - "joined", - "simultaneously", - "subcellular", - "stability", - "predefined", - "multivalent", + "yield", "linkers", - "activities", - "darpins", - "method", - "specificities", + "molecules", "gain", - "blocks", - "design", "high", - "bringing", - "repeats", - "biological", - "connector", - "inherent", - "make", - "demonstrate", - "eight", - "one", - "build", - "conformational", - "avoiding", - "study", - "flexible", - "way", - "together", - "modular", - "different", - "ankyrin", - "darpin", - "changing", - "affinities", - "two", - "exploiting", - "ideal", - "scaffold", - "protein", - "yield", - "complex", - "helix", - "nine", + "compromising", "distinct", - "multispecific", - "binding", - "formed", - "crystallize" + "affinities", + "join", + "inherent" ], "release_date":"2017-09-06", "publication":"\"Rigidly connected multispecific artificial binders with adjustable geometries\", Sci Rep, 7, 11217-11217", @@ -197217,7 +197747,7 @@ }, { "sim":316.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":316.0, @@ -197225,7 +197755,7 @@ }, { "sim":316.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":313.0, @@ -197261,47 +197791,47 @@ }, { "sim":280.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":280.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":280.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":280.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":280.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":280.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":280.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":280.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":280.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":280.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":280.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":280.0, @@ -197309,15 +197839,15 @@ }, { "sim":280.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":280.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":280.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":276.0, @@ -197445,11 +197975,11 @@ }, { "sim":223.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":223.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":223.0, @@ -197489,11 +198019,11 @@ }, { "sim":190.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":190.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":188.0, @@ -197515,6 +198045,10 @@ "sim":175.0, "partner":"4hqd" }, + { + "sim":171.0, + "partner":"9glq" + }, { "sim":169.0, "partner":"5kba" @@ -197585,10 +198119,6 @@ "sim":282.0, "partner":"4hna" }, - { - "sim":280.0, - "partner":"5eno" - }, { "sim":280.0, "partner":"4dx6" @@ -197665,6 +198195,10 @@ "sim":280.0, "partner":"4dx5" }, + { + "sim":280.0, + "partner":"5eno" + }, { "sim":279.0, "partner":"3zu7" @@ -197779,11 +198313,11 @@ }, { "sim":231.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":231.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":224.0, @@ -197953,10 +198487,6 @@ "sim":101.0, "partner":"5gp7" }, - { - "sim":101.0, - "partner":"5vhj" - }, { "sim":101.0, "partner":"5vhh" @@ -197985,6 +198515,10 @@ "sim":101.0, "partner":"5vho" }, + { + "sim":101.0, + "partner":"5vhj" + }, { "sim":101.0, "partner":"5vhp" @@ -198011,15 +198545,15 @@ }, { "sim":100.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":100.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":100.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":99.0, @@ -198031,11 +198565,11 @@ }, { "sim":98.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":98.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":92.0, @@ -198307,11 +198841,11 @@ }, { "sim":66.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":66.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":66.0, @@ -198351,15 +198885,15 @@ }, { "sim":59.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":59.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":59.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":59.0, @@ -198421,6 +198955,10 @@ "sim":51.0, "partner":"1oy3" }, + { + "sim":51.0, + "partner":"8ycp" + }, { "sim":50.0, "partner":"3ljn" @@ -198626,104 +199164,104 @@ ], "subtitle":"Designed armadillo repeat protein yiii(dq)4cqi", "tags":[ - "designed armadillo repeat protein", + "de novo protein", "peptide binding", - "de novo protein" + "designed armadillo repeat protein" ], "keywords":[ + "repeats", + "suitability", + "recognition", + "optimized", + "structural", "interfere", - "analysis", - "geometrically", - "matches", - "thus", - "close", - "chosen", - "scaffolds", - "peptide", - "designed", - "lattice", - "crystal", - "determined", - "target", - "show", - "technology", - "hand", + "development", "repeat", - "computationally", - "fret", - "turned", - "armrps", - "darmrp", - "induce", - "proteins", + "show", + "intention", + "side", + "within", + "ligands", + "parameters", + "adopted", + "protein", + "study", + "binding", + "continuous", + "close", + "essential", + "confirmed", "reality", - "prerequisite", - "small", - "binders", - "recognition", + "armrps", + "two", + "crystal", "binds", - "darmrps", + "chains", + "optimal", + "induce", + "shows", + "divergent", + "computationally", "furthermore", - "structures", - "essential", - "solution", - "suitable", "armadillo", - "exhibit", - "ligands", - "shows", - "suitability", - "consensus", - "previously", - "deviations", - "large", - "optimally", - "geometry", - "intention", - "continuous", - "corroborates", "define", - "divergent", - "optimal", - "12", + "thus", + "residues", + "matches", + "proteins", + "large", + "hand", + "accuracy", + "end", + "consensus", + "modular", + "scaffold", + "small", "bond", - "required", - "high", - "repeats", - "parameters", "unpublished", + "required", + "peptide", + "set", + "curvature", + "12", + "exhibit", + "optimally", + "length", + "fit", + "binders", + "experiments", + "chosen", + "solution", "formation", - "adopted", - "structural", + "backbone", + "technology", + "developed", + "geometrically", "range", - "accuracy", - "chains", - "optimized", - "study", - "length", + "turned", "desired", - "experiments", - "modular", - "confirmed", - "residues", - "two", - "evaluation", - "set", - "scaffold", - "significant", - "protein", + "fret", + "designed", + "analysis", + "corroborates", "calculate", - "backbone", - "development", - "end", - "fit", - "within", - "curvature", - "side", + "evaluation", + "geometry", + "structures", + "suitable", + "previously", + "deviations", + "scaffolds", + "determined", + "target", "curvatures", - "binding", - "developed", - "create" + "darmrps", + "lattice", + "high", + "prerequisite", + "darmrp", + "create", + "significant" ], "release_date":"2017-09-13", "publication":"\"Curvature of designed armadillo repeat proteins allows modular peptide binding\", J. Struct. Biol., 201, 108-117", @@ -198760,11 +199298,11 @@ }, { "sim":417.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":417.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":410.0, @@ -198776,11 +199314,11 @@ }, { "sim":271.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":271.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":271.0, @@ -198792,11 +199330,11 @@ }, { "sim":271.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":271.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":267.0, @@ -198808,11 +199346,11 @@ }, { "sim":266.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":266.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":264.0, @@ -198934,15 +199472,15 @@ }, { "sim":126.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":126.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":126.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":126.0, @@ -198958,15 +199496,15 @@ }, { "sim":124.0, - "partner":"4pvz" + "partner":"1bk5" }, { "sim":124.0, - "partner":"1bk5" + "partner":"1bk6" }, { "sim":124.0, - "partner":"1bk6" + "partner":"4pvz" }, { "sim":124.0, @@ -199000,10 +199538,6 @@ "sim":123.0, "partner":"4u54" }, - { - "sim":123.0, - "partner":"4u5o" - }, { "sim":123.0, "partner":"3ve6" @@ -199032,6 +199566,10 @@ "sim":123.0, "partner":"4u5n" }, + { + "sim":123.0, + "partner":"4u5o" + }, { "sim":123.0, "partner":"3l3q" @@ -199046,11 +199584,11 @@ }, { "sim":123.0, - "partner":"1y2a" + "partner":"4zdu" }, { "sim":123.0, - "partner":"4zdu" + "partner":"1y2a" }, { "sim":123.0, @@ -199060,10 +199598,6 @@ "sim":123.0, "partner":"1ial" }, - { - "sim":123.0, - "partner":"3zir" - }, { "sim":123.0, "partner":"2ynr" @@ -199084,6 +199618,10 @@ "sim":123.0, "partner":"3ziq" }, + { + "sim":123.0, + "partner":"3zir" + }, { "sim":123.0, "partner":"1wa5" @@ -199098,23 +199636,23 @@ }, { "sim":122.0, - "partner":"3q5u" + "partner":"5wun" }, { "sim":122.0, - "partner":"5wum" + "partner":"4oih" }, { "sim":122.0, - "partner":"5wun" + "partner":"5x8n" }, { "sim":122.0, - "partner":"4oih" + "partner":"4yi0" }, { "sim":122.0, - "partner":"5x8n" + "partner":"3knd" }, { "sim":122.0, @@ -199122,31 +199660,31 @@ }, { "sim":122.0, - "partner":"4yi0" + "partner":"1ejy" }, { "sim":122.0, - "partner":"3knd" + "partner":"5b56" }, { "sim":122.0, - "partner":"1ejy" + "partner":"1pjm" }, { "sim":122.0, - "partner":"5b56" + "partner":"1iq1" }, { "sim":122.0, - "partner":"1iq1" + "partner":"1pjn" }, { "sim":122.0, - "partner":"1pjm" + "partner":"3q5u" }, { "sim":122.0, - "partner":"1pjn" + "partner":"5wum" }, { "sim":122.0, @@ -199168,10 +199706,6 @@ "sim":122.0, "partner":"4ba3" }, - { - "sim":122.0, - "partner":"4htv" - }, { "sim":122.0, "partner":"4mz5" @@ -199182,15 +199716,7 @@ }, { "sim":122.0, - "partner":"3rzx" - }, - { - "sim":122.0, - "partner":"5e6q" - }, - { - "sim":122.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":122.0, @@ -199248,6 +199774,18 @@ "sim":122.0, "partner":"5klt" }, + { + "sim":122.0, + "partner":"3rzx" + }, + { + "sim":122.0, + "partner":"5e6q" + }, + { + "sim":122.0, + "partner":"3oqs" + }, { "sim":122.0, "partner":"5huw" @@ -199399,96 +199937,96 @@ ], "subtitle":"Designed armadillo repeat protein yiiim''6aii in complex with pd_(kr)5", "tags":[ - "designed armadillo repeat protein", + "de novo protein", "peptide binding", - "de novo protein" + "designed armadillo repeat protein" ], "keywords":[ - "explained", - "peptide", - "designed", - "lattice", - "crystal", - "show", - "technology", - "green", - "bind", - "interactions", - "conformation", + "correlated", + "recognition", "repeat", - "intended", + "show", + "unstructured", + "interpreted", + "differences", "illustrates", - "even", - "develop", - "darmrp", - "always", - "chain", - "proteins", - "denotes", - "reflect", - "greatly", - "remain", - "characterized", - "nonetheless", - "parts", - "expands", - "short", - "term", - "recognition", - "darmrps", - "fully", - "folded", - "structures", - "solution", - "armadillo", - "either", - "measurements", - "fluorescent", - "crystallization", - "unexpected", - "loops", - "amino", - "phage", - "linkers", "extended", - "report", - "acids", - "caution", - "fused", - "restrictions", - "region", - "behavior", - "interpreted", - "occur", - "applications", - "context", + "fluorescent", + "short", "groove", + "protein", + "restrictions", + "binding", + "fully", "unoccupied", - "correlated", "generic", - "sites", + "domains", "demonstrate", - "lambda", - "also", - "composition", - "peptides", - "modular", + "two", + "applications", + "region", + "crystal", + "always", + "either", + "complex", + "conformation", "engineered", - "unfolded", + "characterized", + "lambda", + "caution", + "armadillo", "residues", - "appear", - "two", - "constitute", - "domains", + "reflect", + "fused", + "occur", + "intended", + "folded", + "bind", "bound", - "protein", - "termini", - "complex", + "proteins", + "develop", + "sites", + "modular", + "explained", "solenoid", - "differences", - "unstructured", + "termini", + "peptide", + "measurements", + "behavior", + "context", + "chain", + "even", + "loops", + "expands", "possible", - "binding" + "appear", + "also", + "parts", + "amino", + "constitute", + "solution", + "technology", + "peptides", + "unfolded", + "nonetheless", + "designed", + "structures", + "crystallization", + "term", + "report", + "interactions", + "darmrps", + "linkers", + "greatly", + "phage", + "lattice", + "denotes", + "remain", + "acids", + "darmrp", + "unexpected", + "composition", + "green" ], "release_date":"2017-07-19", "publication":"\"Structures of designed armadillo repeat proteins binding to peptides fused to globular domains\", Protein Sci., 26, 1942-1952", @@ -199549,11 +200087,11 @@ }, { "sim":502.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":502.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":502.0, @@ -199565,11 +200103,11 @@ }, { "sim":502.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":502.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":486.0, @@ -199577,11 +200115,11 @@ }, { "sim":479.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":479.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":431.0, @@ -199621,11 +200159,11 @@ }, { "sim":301.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":301.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":288.0, @@ -199735,15 +200273,15 @@ }, { "sim":213.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":213.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":213.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":213.0, @@ -199773,10 +200311,6 @@ "sim":205.0, "partner":"4u54" }, - { - "sim":205.0, - "partner":"4u5o" - }, { "sim":205.0, "partner":"3ve6" @@ -199805,6 +200339,10 @@ "sim":205.0, "partner":"4u5n" }, + { + "sim":205.0, + "partner":"4u5o" + }, { "sim":205.0, "partner":"3l3q" @@ -199819,11 +200357,11 @@ }, { "sim":205.0, - "partner":"1y2a" + "partner":"4zdu" }, { "sim":205.0, - "partner":"4zdu" + "partner":"1y2a" }, { "sim":205.0, @@ -199845,10 +200383,6 @@ "sim":205.0, "partner":"1ial" }, - { - "sim":205.0, - "partner":"3zir" - }, { "sim":205.0, "partner":"2ynr" @@ -199870,16 +200404,12 @@ "partner":"3ziq" }, { - "sim":204.0, - "partner":"5k9s" - }, - { - "sim":204.0, - "partner":"3q5u" + "sim":205.0, + "partner":"3zir" }, { "sim":204.0, - "partner":"5wum" + "partner":"5k9s" }, { "sim":204.0, @@ -199895,15 +200425,15 @@ }, { "sim":204.0, - "partner":"1ejl" + "partner":"4yi0" }, { "sim":204.0, - "partner":"4yi0" + "partner":"3knd" }, { "sim":204.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":204.0, @@ -199915,16 +200445,24 @@ }, { "sim":204.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":204.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":204.0, "partner":"1pjn" }, + { + "sim":204.0, + "partner":"3q5u" + }, + { + "sim":204.0, + "partner":"5wum" + }, { "sim":204.0, "partner":"4uaf" @@ -199957,10 +200495,6 @@ "sim":204.0, "partner":"4ba3" }, - { - "sim":204.0, - "partner":"4htv" - }, { "sim":204.0, "partner":"4mz5" @@ -199971,15 +200505,7 @@ }, { "sim":204.0, - "partner":"3rzx" - }, - { - "sim":204.0, - "partner":"5e6q" - }, - { - "sim":204.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":204.0, @@ -200037,6 +200563,18 @@ "sim":204.0, "partner":"5klt" }, + { + "sim":204.0, + "partner":"3rzx" + }, + { + "sim":204.0, + "partner":"5e6q" + }, + { + "sim":204.0, + "partner":"3oqs" + }, { "sim":204.0, "partner":"5huw" @@ -200171,104 +200709,104 @@ ], "subtitle":"Designed armadillo repeat protein yiiim5aii in complex with (rr)4 peptide", "tags":[ - "designed armadillo repeat protein", + "de novo protein", "peptide binding", - "de novo protein" + "designed armadillo repeat protein" ], "keywords":[ + "repeats", + "suitability", + "recognition", + "optimized", + "structural", "interfere", - "analysis", - "geometrically", - "matches", - "thus", - "close", - "chosen", - "scaffolds", - "peptide", - "designed", - "lattice", - "crystal", - "determined", - "target", - "show", - "technology", - "hand", + "development", "repeat", - "computationally", - "fret", - "turned", - "armrps", - "darmrp", - "induce", - "proteins", + "show", + "intention", + "side", + "within", + "ligands", + "parameters", + "adopted", + "protein", + "study", + "binding", + "continuous", + "close", + "essential", + "confirmed", "reality", - "prerequisite", - "small", - "binders", - "recognition", + "armrps", + "two", + "crystal", "binds", - "darmrps", + "chains", + "optimal", + "induce", + "shows", + "divergent", + "computationally", "furthermore", - "structures", - "essential", - "solution", - "suitable", "armadillo", - "exhibit", - "ligands", - "shows", - "suitability", - "consensus", - "previously", - "deviations", - "large", - "optimally", - "geometry", - "intention", - "continuous", - "corroborates", "define", - "divergent", - "optimal", - "12", + "thus", + "residues", + "matches", + "proteins", + "large", + "hand", + "accuracy", + "end", + "consensus", + "modular", + "scaffold", + "small", "bond", - "required", - "high", - "repeats", - "parameters", "unpublished", + "required", + "peptide", + "set", + "curvature", + "12", + "exhibit", + "optimally", + "length", + "fit", + "binders", + "experiments", + "chosen", + "solution", "formation", - "adopted", - "structural", + "backbone", + "technology", + "developed", + "geometrically", "range", - "accuracy", - "chains", - "optimized", - "study", - "length", + "turned", "desired", - "experiments", - "modular", - "confirmed", - "residues", - "two", - "evaluation", - "set", - "scaffold", - "significant", - "protein", + "fret", + "designed", + "analysis", + "corroborates", "calculate", - "backbone", - "development", - "end", - "fit", - "within", - "curvature", - "side", + "evaluation", + "geometry", + "structures", + "suitable", + "previously", + "deviations", + "scaffolds", + "determined", + "target", "curvatures", - "binding", - "developed", - "create" + "darmrps", + "lattice", + "high", + "prerequisite", + "darmrp", + "create", + "significant" ], "release_date":"2017-09-13", "publication":"\"Curvature of designed armadillo repeat proteins allows modular peptide binding\", J. Struct. Biol., 201, 108-117", @@ -200301,23 +200839,23 @@ "seq_thr_sim_designed":[ { "sim":538.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":538.0, - "partner":"5mfn" + "partner":"5mff" }, { "sim":538.0, - "partner":"5mff" + "partner":"5mfg" }, { "sim":538.0, - "partner":"5mfg" + "partner":"5mfh" }, { "sim":538.0, - "partner":"5aei" + "partner":"5mfn" }, { "sim":517.0, @@ -200341,11 +200879,11 @@ }, { "sim":512.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":512.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":504.0, @@ -200401,11 +200939,11 @@ }, { "sim":309.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":309.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":297.0, @@ -200531,15 +201069,15 @@ }, { "sim":185.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":185.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":185.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":185.0, @@ -200585,10 +201123,6 @@ "sim":178.0, "partner":"4u54" }, - { - "sim":178.0, - "partner":"4u5o" - }, { "sim":178.0, "partner":"3ve6" @@ -200617,6 +201151,10 @@ "sim":178.0, "partner":"4u5n" }, + { + "sim":178.0, + "partner":"4u5o" + }, { "sim":178.0, "partner":"3l3q" @@ -200631,11 +201169,11 @@ }, { "sim":178.0, - "partner":"1y2a" + "partner":"4zdu" }, { "sim":178.0, - "partner":"4zdu" + "partner":"1y2a" }, { "sim":178.0, @@ -200649,14 +201187,6 @@ "sim":178.0, "partner":"5k9s" }, - { - "sim":178.0, - "partner":"3q5u" - }, - { - "sim":178.0, - "partner":"5wum" - }, { "sim":178.0, "partner":"5wun" @@ -200671,15 +201201,15 @@ }, { "sim":178.0, - "partner":"1ejl" + "partner":"4yi0" }, { "sim":178.0, - "partner":"4yi0" + "partner":"3knd" }, { "sim":178.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":178.0, @@ -200691,11 +201221,11 @@ }, { "sim":178.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":178.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":178.0, @@ -200703,7 +201233,11 @@ }, { "sim":178.0, - "partner":"3zir" + "partner":"3q5u" + }, + { + "sim":178.0, + "partner":"5wum" }, { "sim":178.0, @@ -200725,6 +201259,10 @@ "sim":178.0, "partner":"3ziq" }, + { + "sim":178.0, + "partner":"3zir" + }, { "sim":178.0, "partner":"4uaf" @@ -200761,10 +201299,6 @@ "sim":178.0, "partner":"4ba3" }, - { - "sim":178.0, - "partner":"4htv" - }, { "sim":178.0, "partner":"4mz5" @@ -200775,15 +201309,7 @@ }, { "sim":178.0, - "partner":"3rzx" - }, - { - "sim":178.0, - "partner":"5e6q" - }, - { - "sim":178.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":178.0, @@ -200841,6 +201367,18 @@ "sim":178.0, "partner":"5klt" }, + { + "sim":178.0, + "partner":"3rzx" + }, + { + "sim":178.0, + "partner":"5e6q" + }, + { + "sim":178.0, + "partner":"3oqs" + }, { "sim":178.0, "partner":"5huw" @@ -200909,7 +201447,7 @@ ], "seq_max_sim_designed":{ "sim":538.0, - "partner":"5mfh" + "partner":"5aei" }, "seq_max_sim_natural":{ "sim":538.0, @@ -200995,104 +201533,104 @@ ], "subtitle":"Designed armadillo repeat protein yiiim5aii in complex with peptide (rr)5", "tags":[ - "designed armadillo repeat protein", + "de novo protein", "peptide binding", - "de novo protein" + "designed armadillo repeat protein" ], "keywords":[ + "repeats", + "suitability", + "recognition", + "optimized", + "structural", "interfere", - "analysis", - "geometrically", - "matches", - "thus", - "close", - "chosen", - "scaffolds", - "peptide", - "designed", - "lattice", - "crystal", - "determined", - "target", - "show", - "technology", - "hand", + "development", "repeat", - "computationally", - "fret", - "turned", - "armrps", - "darmrp", - "induce", - "proteins", + "show", + "intention", + "side", + "within", + "ligands", + "parameters", + "adopted", + "protein", + "study", + "binding", + "continuous", + "close", + "essential", + "confirmed", "reality", - "prerequisite", - "small", - "binders", - "recognition", + "armrps", + "two", + "crystal", "binds", - "darmrps", + "chains", + "optimal", + "induce", + "shows", + "divergent", + "computationally", "furthermore", - "structures", - "essential", - "solution", - "suitable", "armadillo", - "exhibit", - "ligands", - "shows", - "suitability", - "consensus", - "previously", - "deviations", - "large", - "optimally", - "geometry", - "intention", - "continuous", - "corroborates", "define", - "divergent", - "optimal", - "12", + "thus", + "residues", + "matches", + "proteins", + "large", + "hand", + "accuracy", + "end", + "consensus", + "modular", + "scaffold", + "small", "bond", - "required", - "high", - "repeats", - "parameters", "unpublished", + "required", + "peptide", + "set", + "curvature", + "12", + "exhibit", + "optimally", + "length", + "fit", + "binders", + "experiments", + "chosen", + "solution", "formation", - "adopted", - "structural", + "backbone", + "technology", + "developed", + "geometrically", "range", - "accuracy", - "chains", - "optimized", - "study", - "length", + "turned", "desired", - "experiments", - "modular", - "confirmed", - "residues", - "two", - "evaluation", - "set", - "scaffold", - "significant", - "protein", + "fret", + "designed", + "analysis", + "corroborates", "calculate", - "backbone", - "development", - "end", - "fit", - "within", - "curvature", - "side", + "evaluation", + "geometry", + "structures", + "suitable", + "previously", + "deviations", + "scaffolds", + "determined", + "target", "curvatures", - "binding", - "developed", - "create" + "darmrps", + "lattice", + "high", + "prerequisite", + "darmrp", + "create", + "significant" ], "release_date":"2017-09-13", "publication":"\"Curvature of designed armadillo repeat proteins allows modular peptide binding\", J. Struct. Biol., 201, 108-117", @@ -201125,11 +201663,11 @@ "seq_thr_sim_designed":[ { "sim":538.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":538.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":538.0, @@ -201137,11 +201675,11 @@ }, { "sim":538.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":538.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":517.0, @@ -201165,11 +201703,11 @@ }, { "sim":512.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":512.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":504.0, @@ -201225,11 +201763,11 @@ }, { "sim":309.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":309.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":297.0, @@ -201355,15 +201893,15 @@ }, { "sim":185.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":185.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":185.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":185.0, @@ -201409,10 +201947,6 @@ "sim":178.0, "partner":"4u54" }, - { - "sim":178.0, - "partner":"4u5o" - }, { "sim":178.0, "partner":"3ve6" @@ -201441,6 +201975,10 @@ "sim":178.0, "partner":"4u5n" }, + { + "sim":178.0, + "partner":"4u5o" + }, { "sim":178.0, "partner":"3l3q" @@ -201455,11 +201993,11 @@ }, { "sim":178.0, - "partner":"1y2a" + "partner":"4zdu" }, { "sim":178.0, - "partner":"4zdu" + "partner":"1y2a" }, { "sim":178.0, @@ -201473,14 +202011,6 @@ "sim":178.0, "partner":"5k9s" }, - { - "sim":178.0, - "partner":"3q5u" - }, - { - "sim":178.0, - "partner":"5wum" - }, { "sim":178.0, "partner":"5wun" @@ -201495,15 +202025,15 @@ }, { "sim":178.0, - "partner":"1ejl" + "partner":"4yi0" }, { "sim":178.0, - "partner":"4yi0" + "partner":"3knd" }, { "sim":178.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":178.0, @@ -201515,11 +202045,11 @@ }, { "sim":178.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":178.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":178.0, @@ -201527,7 +202057,11 @@ }, { "sim":178.0, - "partner":"3zir" + "partner":"3q5u" + }, + { + "sim":178.0, + "partner":"5wum" }, { "sim":178.0, @@ -201549,6 +202083,10 @@ "sim":178.0, "partner":"3ziq" }, + { + "sim":178.0, + "partner":"3zir" + }, { "sim":178.0, "partner":"4uaf" @@ -201585,10 +202123,6 @@ "sim":178.0, "partner":"4ba3" }, - { - "sim":178.0, - "partner":"4htv" - }, { "sim":178.0, "partner":"4mz5" @@ -201599,15 +202133,7 @@ }, { "sim":178.0, - "partner":"3rzx" - }, - { - "sim":178.0, - "partner":"5e6q" - }, - { - "sim":178.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":178.0, @@ -201665,6 +202191,18 @@ "sim":178.0, "partner":"5klt" }, + { + "sim":178.0, + "partner":"3rzx" + }, + { + "sim":178.0, + "partner":"5e6q" + }, + { + "sim":178.0, + "partner":"3oqs" + }, { "sim":178.0, "partner":"5huw" @@ -201691,6 +202229,14 @@ "sim":0.9757999778, "partner":"5aei" }, + { + "sim":0.9628999829, + "partner":"5mfh" + }, + { + "sim":0.9616000056, + "partner":"5mfe" + }, { "sim":0.9829000235, "partner":"6s9l" @@ -201704,32 +202250,24 @@ "partner":"5mfn" }, { - "sim":0.9765999913, - "partner":"6s9n" - }, - { - "sim":0.9653000236, - "partner":"6sa7" - }, - { - "sim":0.9714000225, - "partner":"6sa8" + "sim":0.9553999901, + "partner":"4v3o" }, { - "sim":0.9628999829, - "partner":"5mfh" + "sim":0.9531000257, + "partner":"4v3r" }, { - "sim":0.9616000056, - "partner":"5mfe" + "sim":0.9765999913, + "partner":"6s9n" }, { - "sim":0.9553999901, - "partner":"4v3o" + "sim":0.9714000225, + "partner":"6sa8" }, { - "sim":0.9531000257, - "partner":"4v3r" + "sim":0.9653000236, + "partner":"6sa7" } ], "struct_thr_sim_natural":[ @@ -201737,7 +202275,7 @@ ], "seq_max_sim_designed":{ "sim":538.0, - "partner":"5mfh" + "partner":"5aei" }, "seq_max_sim_natural":{ "sim":538.0, @@ -201823,104 +202361,104 @@ ], "subtitle":"Designed armadillo repeat protein yiiim5aii in complex with peptide (rr)4", "tags":[ - "designed armadillo repeat protein", + "de novo protein", "peptide binding", - "de novo protein" + "designed armadillo repeat protein" ], "keywords":[ + "repeats", + "suitability", + "recognition", + "optimized", + "structural", "interfere", - "analysis", - "geometrically", - "matches", - "thus", - "close", - "chosen", - "scaffolds", - "peptide", - "designed", - "lattice", - "crystal", - "determined", - "target", - "show", - "technology", - "hand", + "development", "repeat", - "computationally", - "fret", - "turned", - "armrps", - "darmrp", - "induce", - "proteins", + "show", + "intention", + "side", + "within", + "ligands", + "parameters", + "adopted", + "protein", + "study", + "binding", + "continuous", + "close", + "essential", + "confirmed", "reality", - "prerequisite", - "small", - "binders", - "recognition", + "armrps", + "two", + "crystal", "binds", - "darmrps", + "chains", + "optimal", + "induce", + "shows", + "divergent", + "computationally", "furthermore", - "structures", - "essential", - "solution", - "suitable", "armadillo", - "exhibit", - "ligands", - "shows", - "suitability", - "consensus", - "previously", - "deviations", - "large", - "optimally", - "geometry", - "intention", - "continuous", - "corroborates", "define", - "divergent", - "optimal", - "12", + "thus", + "residues", + "matches", + "proteins", + "large", + "hand", + "accuracy", + "end", + "consensus", + "modular", + "scaffold", + "small", "bond", - "required", - "high", - "repeats", - "parameters", "unpublished", + "required", + "peptide", + "set", + "curvature", + "12", + "exhibit", + "optimally", + "length", + "fit", + "binders", + "experiments", + "chosen", + "solution", "formation", - "adopted", - "structural", + "backbone", + "technology", + "developed", + "geometrically", "range", - "accuracy", - "chains", - "optimized", - "study", - "length", + "turned", "desired", - "experiments", - "modular", - "confirmed", - "residues", - "two", - "evaluation", - "set", - "scaffold", - "significant", - "protein", + "fret", + "designed", + "analysis", + "corroborates", "calculate", - "backbone", - "development", - "end", - "fit", - "within", - "curvature", - "side", + "evaluation", + "geometry", + "structures", + "suitable", + "previously", + "deviations", + "scaffolds", + "determined", + "target", "curvatures", - "binding", - "developed", - "create" + "darmrps", + "lattice", + "high", + "prerequisite", + "darmrp", + "create", + "significant" ], "release_date":"2017-09-13", "publication":"\"Curvature of designed armadillo repeat proteins allows modular peptide binding\", J. Struct. Biol., 201, 108-117", @@ -201953,11 +202491,11 @@ "seq_thr_sim_designed":[ { "sim":538.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":538.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":538.0, @@ -201965,11 +202503,11 @@ }, { "sim":538.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":538.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":517.0, @@ -201993,11 +202531,11 @@ }, { "sim":512.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":512.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":504.0, @@ -202053,11 +202591,11 @@ }, { "sim":309.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":309.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":297.0, @@ -202183,15 +202721,15 @@ }, { "sim":185.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":185.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":185.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":185.0, @@ -202237,10 +202775,6 @@ "sim":178.0, "partner":"4u54" }, - { - "sim":178.0, - "partner":"4u5o" - }, { "sim":178.0, "partner":"3ve6" @@ -202269,6 +202803,10 @@ "sim":178.0, "partner":"4u5n" }, + { + "sim":178.0, + "partner":"4u5o" + }, { "sim":178.0, "partner":"3l3q" @@ -202283,11 +202821,11 @@ }, { "sim":178.0, - "partner":"1y2a" + "partner":"4zdu" }, { "sim":178.0, - "partner":"4zdu" + "partner":"1y2a" }, { "sim":178.0, @@ -202301,14 +202839,6 @@ "sim":178.0, "partner":"5k9s" }, - { - "sim":178.0, - "partner":"3q5u" - }, - { - "sim":178.0, - "partner":"5wum" - }, { "sim":178.0, "partner":"5wun" @@ -202323,15 +202853,15 @@ }, { "sim":178.0, - "partner":"1ejl" + "partner":"4yi0" }, { "sim":178.0, - "partner":"4yi0" + "partner":"3knd" }, { "sim":178.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":178.0, @@ -202343,11 +202873,11 @@ }, { "sim":178.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":178.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":178.0, @@ -202355,7 +202885,11 @@ }, { "sim":178.0, - "partner":"3zir" + "partner":"3q5u" + }, + { + "sim":178.0, + "partner":"5wum" }, { "sim":178.0, @@ -202377,6 +202911,10 @@ "sim":178.0, "partner":"3ziq" }, + { + "sim":178.0, + "partner":"3zir" + }, { "sim":178.0, "partner":"4uaf" @@ -202413,10 +202951,6 @@ "sim":178.0, "partner":"4ba3" }, - { - "sim":178.0, - "partner":"4htv" - }, { "sim":178.0, "partner":"4mz5" @@ -202427,15 +202961,7 @@ }, { "sim":178.0, - "partner":"3rzx" - }, - { - "sim":178.0, - "partner":"5e6q" - }, - { - "sim":178.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":178.0, @@ -202493,6 +203019,18 @@ "sim":178.0, "partner":"5klt" }, + { + "sim":178.0, + "partner":"3rzx" + }, + { + "sim":178.0, + "partner":"5e6q" + }, + { + "sim":178.0, + "partner":"3oqs" + }, { "sim":178.0, "partner":"5huw" @@ -202572,7 +203110,7 @@ ], "seq_max_sim_designed":{ "sim":538.0, - "partner":"5mfh" + "partner":"5aei" }, "seq_max_sim_natural":{ "sim":538.0, @@ -202658,104 +203196,104 @@ ], "subtitle":"Designed armadillo repeat protein yiiim5aii in complex with peptide (rr)5", "tags":[ - "designed armadillo repeat protein", + "de novo protein", "peptide binding", - "de novo protein" + "designed armadillo repeat protein" ], "keywords":[ + "repeats", + "suitability", + "recognition", + "optimized", + "structural", "interfere", - "analysis", - "geometrically", - "matches", - "thus", - "close", - "chosen", - "scaffolds", - "peptide", - "designed", - "lattice", - "crystal", - "determined", - "target", - "show", - "technology", - "hand", + "development", "repeat", - "computationally", - "fret", - "turned", - "armrps", - "darmrp", - "induce", - "proteins", + "show", + "intention", + "side", + "within", + "ligands", + "parameters", + "adopted", + "protein", + "study", + "binding", + "continuous", + "close", + "essential", + "confirmed", "reality", - "prerequisite", - "small", - "binders", - "recognition", + "armrps", + "two", + "crystal", "binds", - "darmrps", + "chains", + "optimal", + "induce", + "shows", + "divergent", + "computationally", "furthermore", - "structures", - "essential", - "solution", - "suitable", "armadillo", - "exhibit", - "ligands", - "shows", - "suitability", - "consensus", - "previously", - "deviations", - "large", - "optimally", - "geometry", - "intention", - "continuous", - "corroborates", "define", - "divergent", - "optimal", - "12", + "thus", + "residues", + "matches", + "proteins", + "large", + "hand", + "accuracy", + "end", + "consensus", + "modular", + "scaffold", + "small", "bond", - "required", - "high", - "repeats", - "parameters", "unpublished", + "required", + "peptide", + "set", + "curvature", + "12", + "exhibit", + "optimally", + "length", + "fit", + "binders", + "experiments", + "chosen", + "solution", "formation", - "adopted", - "structural", + "backbone", + "technology", + "developed", + "geometrically", "range", - "accuracy", - "chains", - "optimized", - "study", - "length", + "turned", "desired", - "experiments", - "modular", - "confirmed", - "residues", - "two", - "evaluation", - "set", - "scaffold", - "significant", - "protein", + "fret", + "designed", + "analysis", + "corroborates", "calculate", - "backbone", - "development", - "end", - "fit", - "within", - "curvature", - "side", + "evaluation", + "geometry", + "structures", + "suitable", + "previously", + "deviations", + "scaffolds", + "determined", + "target", "curvatures", - "binding", - "developed", - "create" + "darmrps", + "lattice", + "high", + "prerequisite", + "darmrp", + "create", + "significant" ], "release_date":"2017-09-13", "publication":"\"Curvature of designed armadillo repeat proteins allows modular peptide binding\", J. Struct. Biol., 201, 108-117", @@ -202788,23 +203326,23 @@ "seq_thr_sim_designed":[ { "sim":538.0, - "partner":"5mfn" + "partner":"5aei" }, { "sim":538.0, - "partner":"5mff" + "partner":"5mfe" }, { "sim":538.0, - "partner":"5mfg" + "partner":"5mff" }, { "sim":538.0, - "partner":"5aei" + "partner":"5mfg" }, { "sim":538.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":517.0, @@ -202828,11 +203366,11 @@ }, { "sim":512.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":512.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":504.0, @@ -202888,11 +203426,11 @@ }, { "sim":309.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":309.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":297.0, @@ -203018,15 +203556,15 @@ }, { "sim":185.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":185.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":185.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":185.0, @@ -203072,10 +203610,6 @@ "sim":178.0, "partner":"4u54" }, - { - "sim":178.0, - "partner":"4u5o" - }, { "sim":178.0, "partner":"3ve6" @@ -203104,6 +203638,10 @@ "sim":178.0, "partner":"4u5n" }, + { + "sim":178.0, + "partner":"4u5o" + }, { "sim":178.0, "partner":"3l3q" @@ -203118,11 +203656,11 @@ }, { "sim":178.0, - "partner":"1y2a" + "partner":"4zdu" }, { "sim":178.0, - "partner":"4zdu" + "partner":"1y2a" }, { "sim":178.0, @@ -203136,14 +203674,6 @@ "sim":178.0, "partner":"5k9s" }, - { - "sim":178.0, - "partner":"3q5u" - }, - { - "sim":178.0, - "partner":"5wum" - }, { "sim":178.0, "partner":"5wun" @@ -203158,15 +203688,15 @@ }, { "sim":178.0, - "partner":"1ejl" + "partner":"4yi0" }, { "sim":178.0, - "partner":"4yi0" + "partner":"3knd" }, { "sim":178.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":178.0, @@ -203178,11 +203708,11 @@ }, { "sim":178.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":178.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":178.0, @@ -203190,7 +203720,11 @@ }, { "sim":178.0, - "partner":"3zir" + "partner":"3q5u" + }, + { + "sim":178.0, + "partner":"5wum" }, { "sim":178.0, @@ -203212,6 +203746,10 @@ "sim":178.0, "partner":"3ziq" }, + { + "sim":178.0, + "partner":"3zir" + }, { "sim":178.0, "partner":"4uaf" @@ -203248,10 +203786,6 @@ "sim":178.0, "partner":"4ba3" }, - { - "sim":178.0, - "partner":"4htv" - }, { "sim":178.0, "partner":"4mz5" @@ -203262,15 +203796,7 @@ }, { "sim":178.0, - "partner":"3rzx" - }, - { - "sim":178.0, - "partner":"5e6q" - }, - { - "sim":178.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":178.0, @@ -203328,6 +203854,18 @@ "sim":178.0, "partner":"5klt" }, + { + "sim":178.0, + "partner":"3rzx" + }, + { + "sim":178.0, + "partner":"5e6q" + }, + { + "sim":178.0, + "partner":"3oqs" + }, { "sim":178.0, "partner":"5huw" @@ -203392,7 +203930,7 @@ ], "seq_max_sim_designed":{ "sim":538.0, - "partner":"5mfn" + "partner":"5aei" }, "seq_max_sim_natural":{ "sim":538.0, @@ -203478,105 +204016,105 @@ ], "subtitle":"Designed armadillo repeat protein yiii(dq.v2)4cqi in complex with peptide (kr)4", "tags":[ - "designed armadillo repeat protein", - "peptide binding", "de novo protein", - "de novo proein" + "de novo proein", + "peptide binding", + "designed armadillo repeat protein" ], "keywords":[ + "repeats", + "suitability", + "recognition", + "optimized", + "structural", "interfere", - "analysis", - "geometrically", - "matches", - "thus", - "close", - "chosen", - "scaffolds", - "peptide", - "designed", - "lattice", - "crystal", - "determined", - "target", - "show", - "technology", - "hand", + "development", "repeat", - "computationally", - "fret", - "turned", - "armrps", - "darmrp", - "induce", - "proteins", + "show", + "intention", + "side", + "within", + "ligands", + "parameters", + "adopted", + "protein", + "study", + "binding", + "continuous", + "close", + "essential", + "confirmed", "reality", - "prerequisite", - "small", - "binders", - "recognition", + "armrps", + "two", + "crystal", "binds", - "darmrps", + "chains", + "optimal", + "induce", + "shows", + "divergent", + "computationally", "furthermore", - "structures", - "essential", - "solution", - "suitable", "armadillo", - "exhibit", - "ligands", - "shows", - "suitability", - "consensus", - "previously", - "deviations", - "large", - "optimally", - "geometry", - "intention", - "continuous", - "corroborates", "define", - "divergent", - "optimal", - "12", + "thus", + "residues", + "matches", + "proteins", + "large", + "hand", + "accuracy", + "end", + "consensus", + "modular", + "scaffold", + "small", "bond", - "required", - "high", - "repeats", - "parameters", "unpublished", + "required", + "peptide", + "set", + "curvature", + "12", + "exhibit", + "optimally", + "length", + "fit", + "binders", + "experiments", + "chosen", + "solution", "formation", - "adopted", - "structural", + "backbone", + "technology", + "developed", + "geometrically", "range", - "accuracy", - "chains", - "optimized", - "study", - "length", + "turned", "desired", - "experiments", - "modular", - "confirmed", - "residues", - "two", - "evaluation", - "set", - "scaffold", - "significant", - "protein", + "fret", + "designed", + "analysis", + "corroborates", "calculate", - "backbone", - "development", - "end", - "fit", - "within", - "curvature", - "side", + "evaluation", + "geometry", + "structures", + "suitable", + "previously", + "deviations", + "scaffolds", + "determined", + "target", "curvatures", - "binding", - "developed", - "create" + "darmrps", + "lattice", + "high", + "prerequisite", + "darmrp", + "create", + "significant" ], "release_date":"2017-09-13", "publication":"\"Curvature of designed armadillo repeat proteins allows modular peptide binding\", J. Struct. Biol., 201, 108-117", @@ -203629,11 +204167,11 @@ }, { "sim":312.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":312.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":312.0, @@ -203645,11 +204183,11 @@ }, { "sim":312.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":312.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":308.0, @@ -203681,11 +204219,11 @@ }, { "sim":289.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":289.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":287.0, @@ -203795,15 +204333,15 @@ }, { "sim":137.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":137.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":137.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":137.0, @@ -203811,7 +204349,7 @@ }, { "sim":136.0, - "partner":"4pvz" + "partner":"3tpm" }, { "sim":136.0, @@ -203819,11 +204357,11 @@ }, { "sim":136.0, - "partner":"3tpm" + "partner":"1bk6" }, { "sim":136.0, - "partner":"1bk6" + "partner":"4pvz" }, { "sim":136.0, @@ -203845,10 +204383,6 @@ "sim":136.0, "partner":"4u54" }, - { - "sim":136.0, - "partner":"4u5o" - }, { "sim":136.0, "partner":"3ve6" @@ -203877,6 +204411,10 @@ "sim":136.0, "partner":"4u5n" }, + { + "sim":136.0, + "partner":"4u5o" + }, { "sim":136.0, "partner":"3l3q" @@ -203891,11 +204429,11 @@ }, { "sim":136.0, - "partner":"1y2a" + "partner":"4zdu" }, { "sim":136.0, - "partner":"4zdu" + "partner":"1y2a" }, { "sim":136.0, @@ -203913,10 +204451,6 @@ "sim":136.0, "partner":"2c1t" }, - { - "sim":136.0, - "partner":"3zir" - }, { "sim":136.0, "partner":"2ynr" @@ -203938,16 +204472,12 @@ "partner":"3ziq" }, { - "sim":135.0, - "partner":"5k9s" - }, - { - "sim":135.0, - "partner":"3q5u" + "sim":136.0, + "partner":"3zir" }, { "sim":135.0, - "partner":"5wum" + "partner":"5k9s" }, { "sim":135.0, @@ -203963,15 +204493,15 @@ }, { "sim":135.0, - "partner":"1ejl" + "partner":"4yi0" }, { "sim":135.0, - "partner":"4yi0" + "partner":"3knd" }, { "sim":135.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":135.0, @@ -203983,16 +204513,24 @@ }, { "sim":135.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":135.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":135.0, "partner":"1pjn" }, + { + "sim":135.0, + "partner":"3q5u" + }, + { + "sim":135.0, + "partner":"5wum" + }, { "sim":135.0, "partner":"4uaf" @@ -204013,10 +204551,6 @@ "sim":135.0, "partner":"4ba3" }, - { - "sim":135.0, - "partner":"4htv" - }, { "sim":135.0, "partner":"4mz5" @@ -204027,15 +204561,7 @@ }, { "sim":135.0, - "partner":"3rzx" - }, - { - "sim":135.0, - "partner":"5e6q" - }, - { - "sim":135.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":135.0, @@ -204093,6 +204619,18 @@ "sim":135.0, "partner":"5klt" }, + { + "sim":135.0, + "partner":"3rzx" + }, + { + "sim":135.0, + "partner":"5e6q" + }, + { + "sim":135.0, + "partner":"3oqs" + }, { "sim":135.0, "partner":"5huw" @@ -204271,104 +204809,104 @@ ], "subtitle":"Designed armadillo repeat protein yiii(dq.v2)4cqi in complex with peptide (kr)5", "tags":[ - "designed armadillo repeat protein", + "de novo protein", "peptide binding", - "de novo protein" + "designed armadillo repeat protein" ], "keywords":[ + "repeats", + "suitability", + "recognition", + "optimized", + "structural", "interfere", - "analysis", - "geometrically", - "matches", - "thus", - "close", - "chosen", - "scaffolds", - "peptide", - "designed", - "lattice", - "crystal", - "determined", - "target", - "show", - "technology", - "hand", + "development", "repeat", - "computationally", - "fret", - "turned", - "armrps", - "darmrp", - "induce", - "proteins", + "show", + "intention", + "side", + "within", + "ligands", + "parameters", + "adopted", + "protein", + "study", + "binding", + "continuous", + "close", + "essential", + "confirmed", "reality", - "prerequisite", - "small", - "binders", - "recognition", + "armrps", + "two", + "crystal", "binds", - "darmrps", + "chains", + "optimal", + "induce", + "shows", + "divergent", + "computationally", "furthermore", - "structures", - "essential", - "solution", - "suitable", "armadillo", - "exhibit", - "ligands", - "shows", - "suitability", - "consensus", - "previously", - "deviations", - "large", - "optimally", - "geometry", - "intention", - "continuous", - "corroborates", "define", - "divergent", - "optimal", - "12", + "thus", + "residues", + "matches", + "proteins", + "large", + "hand", + "accuracy", + "end", + "consensus", + "modular", + "scaffold", + "small", "bond", - "required", - "high", - "repeats", - "parameters", "unpublished", + "required", + "peptide", + "set", + "curvature", + "12", + "exhibit", + "optimally", + "length", + "fit", + "binders", + "experiments", + "chosen", + "solution", "formation", - "adopted", - "structural", + "backbone", + "technology", + "developed", + "geometrically", "range", - "accuracy", - "chains", - "optimized", - "study", - "length", + "turned", "desired", - "experiments", - "modular", - "confirmed", - "residues", - "two", - "evaluation", - "set", - "scaffold", - "significant", - "protein", + "fret", + "designed", + "analysis", + "corroborates", "calculate", - "backbone", - "development", - "end", - "fit", - "within", - "curvature", - "side", + "evaluation", + "geometry", + "structures", + "suitable", + "previously", + "deviations", + "scaffolds", + "determined", + "target", "curvatures", - "binding", - "developed", - "create" + "darmrps", + "lattice", + "high", + "prerequisite", + "darmrp", + "create", + "significant" ], "release_date":"2017-09-13", "publication":"\"Curvature of designed armadillo repeat proteins allows modular peptide binding\", J. Struct. Biol., 201, 108-117", @@ -204421,11 +204959,11 @@ }, { "sim":312.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":312.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":312.0, @@ -204437,11 +204975,11 @@ }, { "sim":312.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":312.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":308.0, @@ -204473,11 +205011,11 @@ }, { "sim":289.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":289.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":287.0, @@ -204587,15 +205125,15 @@ }, { "sim":137.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":137.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":137.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":137.0, @@ -204603,7 +205141,7 @@ }, { "sim":136.0, - "partner":"4pvz" + "partner":"3tpm" }, { "sim":136.0, @@ -204611,11 +205149,11 @@ }, { "sim":136.0, - "partner":"3tpm" + "partner":"1bk6" }, { "sim":136.0, - "partner":"1bk6" + "partner":"4pvz" }, { "sim":136.0, @@ -204637,10 +205175,6 @@ "sim":136.0, "partner":"4u54" }, - { - "sim":136.0, - "partner":"4u5o" - }, { "sim":136.0, "partner":"3ve6" @@ -204669,6 +205203,10 @@ "sim":136.0, "partner":"4u5n" }, + { + "sim":136.0, + "partner":"4u5o" + }, { "sim":136.0, "partner":"3l3q" @@ -204683,11 +205221,11 @@ }, { "sim":136.0, - "partner":"1y2a" + "partner":"4zdu" }, { "sim":136.0, - "partner":"4zdu" + "partner":"1y2a" }, { "sim":136.0, @@ -204705,10 +205243,6 @@ "sim":136.0, "partner":"2c1t" }, - { - "sim":136.0, - "partner":"3zir" - }, { "sim":136.0, "partner":"2ynr" @@ -204730,16 +205264,12 @@ "partner":"3ziq" }, { - "sim":135.0, - "partner":"5k9s" - }, - { - "sim":135.0, - "partner":"3q5u" + "sim":136.0, + "partner":"3zir" }, { "sim":135.0, - "partner":"5wum" + "partner":"5k9s" }, { "sim":135.0, @@ -204755,15 +205285,15 @@ }, { "sim":135.0, - "partner":"1ejl" + "partner":"4yi0" }, { "sim":135.0, - "partner":"4yi0" + "partner":"3knd" }, { "sim":135.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":135.0, @@ -204775,16 +205305,24 @@ }, { "sim":135.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":135.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":135.0, "partner":"1pjn" }, + { + "sim":135.0, + "partner":"3q5u" + }, + { + "sim":135.0, + "partner":"5wum" + }, { "sim":135.0, "partner":"4uaf" @@ -204805,10 +205343,6 @@ "sim":135.0, "partner":"4ba3" }, - { - "sim":135.0, - "partner":"4htv" - }, { "sim":135.0, "partner":"4mz5" @@ -204819,15 +205353,7 @@ }, { "sim":135.0, - "partner":"3rzx" - }, - { - "sim":135.0, - "partner":"5e6q" - }, - { - "sim":135.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":135.0, @@ -204885,6 +205411,18 @@ "sim":135.0, "partner":"5klt" }, + { + "sim":135.0, + "partner":"3rzx" + }, + { + "sim":135.0, + "partner":"5e6q" + }, + { + "sim":135.0, + "partner":"3oqs" + }, { "sim":135.0, "partner":"5huw" @@ -205063,104 +205601,104 @@ ], "subtitle":"Designed armadillo repeat protein yiii(dq.v1)4cpaf in complex with peptide (kr)4", "tags":[ - "designed armadillo repeat protein", + "de novo protein", "peptide binding", - "de novo protein" + "designed armadillo repeat protein" ], "keywords":[ + "repeats", + "suitability", + "recognition", + "optimized", + "structural", "interfere", - "analysis", - "geometrically", - "matches", - "thus", - "close", - "chosen", - "scaffolds", - "peptide", - "designed", - "lattice", - "crystal", - "determined", - "target", - "show", - "technology", - "hand", + "development", "repeat", - "computationally", - "fret", - "turned", - "armrps", - "darmrp", - "induce", - "proteins", + "show", + "intention", + "side", + "within", + "ligands", + "parameters", + "adopted", + "protein", + "study", + "binding", + "continuous", + "close", + "essential", + "confirmed", "reality", - "prerequisite", - "small", - "binders", - "recognition", + "armrps", + "two", + "crystal", "binds", - "darmrps", + "chains", + "optimal", + "induce", + "shows", + "divergent", + "computationally", "furthermore", - "structures", - "essential", - "solution", - "suitable", "armadillo", - "exhibit", - "ligands", - "shows", - "suitability", - "consensus", - "previously", - "deviations", - "large", - "optimally", - "geometry", - "intention", - "continuous", - "corroborates", "define", - "divergent", - "optimal", - "12", + "thus", + "residues", + "matches", + "proteins", + "large", + "hand", + "accuracy", + "end", + "consensus", + "modular", + "scaffold", + "small", "bond", - "required", - "high", - "repeats", - "parameters", "unpublished", + "required", + "peptide", + "set", + "curvature", + "12", + "exhibit", + "optimally", + "length", + "fit", + "binders", + "experiments", + "chosen", + "solution", "formation", - "adopted", - "structural", + "backbone", + "technology", + "developed", + "geometrically", "range", - "accuracy", - "chains", - "optimized", - "study", - "length", + "turned", "desired", - "experiments", - "modular", - "confirmed", - "residues", - "two", - "evaluation", - "set", - "scaffold", - "significant", - "protein", + "fret", + "designed", + "analysis", + "corroborates", "calculate", - "backbone", - "development", - "end", - "fit", - "within", - "curvature", - "side", + "evaluation", + "geometry", + "structures", + "suitable", + "previously", + "deviations", + "scaffolds", + "determined", + "target", "curvatures", - "binding", - "developed", - "create" + "darmrps", + "lattice", + "high", + "prerequisite", + "darmrp", + "create", + "significant" ], "release_date":"2017-09-13", "publication":"\"Curvature of designed armadillo repeat proteins allows modular peptide binding\", J. Struct. Biol., 201, 108-117", @@ -205197,11 +205735,11 @@ }, { "sim":437.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":437.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":412.0, @@ -205213,11 +205751,11 @@ }, { "sim":298.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":298.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":298.0, @@ -205229,11 +205767,11 @@ }, { "sim":298.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":298.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":293.0, @@ -205367,15 +205905,15 @@ }, { "sim":149.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":149.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":149.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":149.0, @@ -205397,10 +205935,6 @@ "sim":143.0, "partner":"4u54" }, - { - "sim":143.0, - "partner":"4u5o" - }, { "sim":143.0, "partner":"3ve6" @@ -205429,6 +205963,10 @@ "sim":143.0, "partner":"4u5n" }, + { + "sim":143.0, + "partner":"4u5o" + }, { "sim":143.0, "partner":"3l3q" @@ -205443,11 +205981,11 @@ }, { "sim":143.0, - "partner":"1y2a" + "partner":"4zdu" }, { "sim":143.0, - "partner":"4zdu" + "partner":"1y2a" }, { "sim":143.0, @@ -205457,10 +205995,6 @@ "sim":143.0, "partner":"1ial" }, - { - "sim":143.0, - "partner":"3zir" - }, { "sim":143.0, "partner":"2ynr" @@ -205481,6 +206015,10 @@ "sim":143.0, "partner":"3ziq" }, + { + "sim":143.0, + "partner":"3zir" + }, { "sim":142.0, "partner":"1ee5" @@ -205491,23 +206029,23 @@ }, { "sim":142.0, - "partner":"3q5u" + "partner":"5wun" }, { "sim":142.0, - "partner":"5wum" + "partner":"4oih" }, { "sim":142.0, - "partner":"5wun" + "partner":"5x8n" }, { "sim":142.0, - "partner":"4oih" + "partner":"4yi0" }, { "sim":142.0, - "partner":"5x8n" + "partner":"3knd" }, { "sim":142.0, @@ -205515,31 +206053,31 @@ }, { "sim":142.0, - "partner":"4yi0" + "partner":"1ejy" }, { "sim":142.0, - "partner":"3knd" + "partner":"5b56" }, { "sim":142.0, - "partner":"1ejy" + "partner":"1pjm" }, { "sim":142.0, - "partner":"5b56" + "partner":"1iq1" }, { "sim":142.0, - "partner":"1iq1" + "partner":"1pjn" }, { "sim":142.0, - "partner":"1pjm" + "partner":"3q5u" }, { "sim":142.0, - "partner":"1pjn" + "partner":"5wum" }, { "sim":142.0, @@ -205561,10 +206099,6 @@ "sim":142.0, "partner":"4ba3" }, - { - "sim":142.0, - "partner":"4htv" - }, { "sim":142.0, "partner":"4mz5" @@ -205575,15 +206109,7 @@ }, { "sim":142.0, - "partner":"3rzx" - }, - { - "sim":142.0, - "partner":"5e6q" - }, - { - "sim":142.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":142.0, @@ -205641,6 +206167,18 @@ "sim":142.0, "partner":"5klt" }, + { + "sim":142.0, + "partner":"3rzx" + }, + { + "sim":142.0, + "partner":"5e6q" + }, + { + "sim":142.0, + "partner":"3oqs" + }, { "sim":142.0, "partner":"5huw" @@ -205683,15 +206221,15 @@ }, { "sim":140.0, - "partner":"4pvz" + "partner":"1bk5" }, { "sim":140.0, - "partner":"1bk5" + "partner":"1bk6" }, { "sim":140.0, - "partner":"1bk6" + "partner":"4pvz" }, { "sim":140.0, @@ -205851,104 +206389,104 @@ ], "subtitle":"Designed armadillo repeat protein (kr)5_gs10_yiiim6aii", "tags":[ - "designed armadillo repeat protein", + "de novo protein", "peptide binding", - "de novo protein" + "designed armadillo repeat protein" ], "keywords":[ + "repeats", + "suitability", + "recognition", + "optimized", + "structural", "interfere", - "analysis", - "geometrically", - "matches", - "thus", - "close", - "chosen", - "scaffolds", - "peptide", - "designed", - "lattice", - "crystal", - "determined", - "target", - "show", - "technology", - "hand", + "development", "repeat", - "computationally", - "fret", - "turned", - "armrps", - "darmrp", - "induce", - "proteins", + "show", + "intention", + "side", + "within", + "ligands", + "parameters", + "adopted", + "protein", + "study", + "binding", + "continuous", + "close", + "essential", + "confirmed", "reality", - "prerequisite", - "small", - "binders", - "recognition", + "armrps", + "two", + "crystal", "binds", - "darmrps", + "chains", + "optimal", + "induce", + "shows", + "divergent", + "computationally", "furthermore", - "structures", - "essential", - "solution", - "suitable", "armadillo", - "exhibit", - "ligands", - "shows", - "suitability", - "consensus", - "previously", - "deviations", - "large", - "optimally", - "geometry", - "intention", - "continuous", - "corroborates", "define", - "divergent", - "optimal", - "12", + "thus", + "residues", + "matches", + "proteins", + "large", + "hand", + "accuracy", + "end", + "consensus", + "modular", + "scaffold", + "small", "bond", - "required", - "high", - "repeats", - "parameters", "unpublished", + "required", + "peptide", + "set", + "curvature", + "12", + "exhibit", + "optimally", + "length", + "fit", + "binders", + "experiments", + "chosen", + "solution", "formation", - "adopted", - "structural", + "backbone", + "technology", + "developed", + "geometrically", "range", - "accuracy", - "chains", - "optimized", - "study", - "length", + "turned", "desired", - "experiments", - "modular", - "confirmed", - "residues", - "two", - "evaluation", - "set", - "scaffold", - "significant", - "protein", + "fret", + "designed", + "analysis", + "corroborates", "calculate", - "backbone", - "development", - "end", - "fit", - "within", - "curvature", - "side", + "evaluation", + "geometry", + "structures", + "suitable", + "previously", + "deviations", + "scaffolds", + "determined", + "target", "curvatures", - "binding", - "developed", - "create" + "darmrps", + "lattice", + "high", + "prerequisite", + "darmrp", + "create", + "significant" ], "release_date":"2017-09-13", "publication":"\"Curvature of designed armadillo repeat proteins allows modular peptide binding\", J. Struct. Biol., 201, 108-117", @@ -206001,11 +206539,11 @@ }, { "sim":512.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":512.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":512.0, @@ -206017,11 +206555,11 @@ }, { "sim":512.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":512.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":496.0, @@ -206037,11 +206575,11 @@ }, { "sim":486.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":486.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":434.0, @@ -206081,11 +206619,11 @@ }, { "sim":304.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":304.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":291.0, @@ -206155,11 +206693,11 @@ }, { "sim":228.0, - "partner":"1ee4" + "partner":"4xzr" }, { "sim":228.0, - "partner":"4xzr" + "partner":"1ee4" }, { "sim":228.0, @@ -206207,15 +206745,15 @@ }, { "sim":214.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":214.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":214.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":214.0, @@ -206233,10 +206771,6 @@ "sim":213.0, "partner":"4u54" }, - { - "sim":213.0, - "partner":"4u5o" - }, { "sim":213.0, "partner":"3ve6" @@ -206265,6 +206799,10 @@ "sim":213.0, "partner":"4u5n" }, + { + "sim":213.0, + "partner":"4u5o" + }, { "sim":213.0, "partner":"3l3q" @@ -206279,11 +206817,11 @@ }, { "sim":213.0, - "partner":"1y2a" + "partner":"4zdu" }, { "sim":213.0, - "partner":"4zdu" + "partner":"1y2a" }, { "sim":213.0, @@ -206293,10 +206831,6 @@ "sim":213.0, "partner":"1ial" }, - { - "sim":213.0, - "partner":"3zir" - }, { "sim":213.0, "partner":"2ynr" @@ -206317,6 +206851,10 @@ "sim":213.0, "partner":"3ziq" }, + { + "sim":213.0, + "partner":"3zir" + }, { "sim":212.0, "partner":"5xzx" @@ -206331,23 +206869,23 @@ }, { "sim":212.0, - "partner":"3q5u" + "partner":"5wun" }, { "sim":212.0, - "partner":"5wum" + "partner":"4oih" }, { "sim":212.0, - "partner":"5wun" + "partner":"5x8n" }, { "sim":212.0, - "partner":"4oih" + "partner":"4yi0" }, { "sim":212.0, - "partner":"5x8n" + "partner":"3knd" }, { "sim":212.0, @@ -206355,31 +206893,31 @@ }, { "sim":212.0, - "partner":"4yi0" + "partner":"1ejy" }, { "sim":212.0, - "partner":"3knd" + "partner":"5b56" }, { "sim":212.0, - "partner":"1ejy" + "partner":"1pjm" }, { "sim":212.0, - "partner":"5b56" + "partner":"1iq1" }, { "sim":212.0, - "partner":"1iq1" + "partner":"1pjn" }, { "sim":212.0, - "partner":"1pjm" + "partner":"3q5u" }, { "sim":212.0, - "partner":"1pjn" + "partner":"5wum" }, { "sim":212.0, @@ -206401,10 +206939,6 @@ "sim":212.0, "partner":"4ba3" }, - { - "sim":212.0, - "partner":"4htv" - }, { "sim":212.0, "partner":"4mz5" @@ -206415,15 +206949,7 @@ }, { "sim":212.0, - "partner":"3rzx" - }, - { - "sim":212.0, - "partner":"5e6q" - }, - { - "sim":212.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":212.0, @@ -206481,6 +207007,18 @@ "sim":212.0, "partner":"5klt" }, + { + "sim":212.0, + "partner":"3rzx" + }, + { + "sim":212.0, + "partner":"5e6q" + }, + { + "sim":212.0, + "partner":"3oqs" + }, { "sim":212.0, "partner":"5tbk" @@ -206631,104 +207169,104 @@ ], "subtitle":"Designed armadillo repeat protein yiiim5aii", "tags":[ - "designed armadillo repeat protein", + "de novo protein", "peptide binding", - "de novo protein" + "designed armadillo repeat protein" ], "keywords":[ + "repeats", + "suitability", + "recognition", + "optimized", + "structural", "interfere", - "analysis", - "geometrically", - "matches", - "thus", - "close", - "chosen", - "scaffolds", - "peptide", - "designed", - "lattice", - "crystal", - "determined", - "target", - "show", - "technology", - "hand", + "development", "repeat", - "computationally", - "fret", - "turned", - "armrps", - "darmrp", - "induce", - "proteins", + "show", + "intention", + "side", + "within", + "ligands", + "parameters", + "adopted", + "protein", + "study", + "binding", + "continuous", + "close", + "essential", + "confirmed", "reality", - "prerequisite", - "small", - "binders", - "recognition", + "armrps", + "two", + "crystal", "binds", - "darmrps", + "chains", + "optimal", + "induce", + "shows", + "divergent", + "computationally", "furthermore", - "structures", - "essential", - "solution", - "suitable", "armadillo", - "exhibit", - "ligands", - "shows", - "suitability", - "consensus", - "previously", - "deviations", - "large", - "optimally", - "geometry", - "intention", - "continuous", - "corroborates", "define", - "divergent", - "optimal", - "12", + "thus", + "residues", + "matches", + "proteins", + "large", + "hand", + "accuracy", + "end", + "consensus", + "modular", + "scaffold", + "small", "bond", - "required", - "high", - "repeats", - "parameters", "unpublished", + "required", + "peptide", + "set", + "curvature", + "12", + "exhibit", + "optimally", + "length", + "fit", + "binders", + "experiments", + "chosen", + "solution", "formation", - "adopted", - "structural", + "backbone", + "technology", + "developed", + "geometrically", "range", - "accuracy", - "chains", - "optimized", - "study", - "length", + "turned", "desired", - "experiments", - "modular", - "confirmed", - "residues", - "two", - "evaluation", - "set", - "scaffold", - "significant", - "protein", + "fret", + "designed", + "analysis", + "corroborates", "calculate", - "backbone", - "development", - "end", - "fit", - "within", - "curvature", - "side", + "evaluation", + "geometry", + "structures", + "suitable", + "previously", + "deviations", + "scaffolds", + "determined", + "target", "curvatures", - "binding", - "developed", - "create" + "darmrps", + "lattice", + "high", + "prerequisite", + "darmrp", + "create", + "significant" ], "release_date":"2017-09-13", "publication":"\"Curvature of designed armadillo repeat proteins allows modular peptide binding\", J. Struct. Biol., 201, 108-117", @@ -206761,23 +207299,23 @@ "seq_thr_sim_designed":[ { "sim":538.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":538.0, - "partner":"5mff" + "partner":"5mfe" }, { "sim":538.0, - "partner":"5mfg" + "partner":"5mff" }, { "sim":538.0, - "partner":"5aei" + "partner":"5mfg" }, { "sim":538.0, - "partner":"5mfe" + "partner":"5mfh" }, { "sim":517.0, @@ -206801,11 +207339,11 @@ }, { "sim":512.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":512.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":504.0, @@ -206861,11 +207399,11 @@ }, { "sim":309.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":309.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":297.0, @@ -206991,15 +207529,15 @@ }, { "sim":185.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":185.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":185.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":185.0, @@ -207045,10 +207583,6 @@ "sim":178.0, "partner":"4u54" }, - { - "sim":178.0, - "partner":"4u5o" - }, { "sim":178.0, "partner":"3ve6" @@ -207077,6 +207611,10 @@ "sim":178.0, "partner":"4u5n" }, + { + "sim":178.0, + "partner":"4u5o" + }, { "sim":178.0, "partner":"3l3q" @@ -207091,11 +207629,11 @@ }, { "sim":178.0, - "partner":"1y2a" + "partner":"4zdu" }, { "sim":178.0, - "partner":"4zdu" + "partner":"1y2a" }, { "sim":178.0, @@ -207109,14 +207647,6 @@ "sim":178.0, "partner":"5k9s" }, - { - "sim":178.0, - "partner":"3q5u" - }, - { - "sim":178.0, - "partner":"5wum" - }, { "sim":178.0, "partner":"5wun" @@ -207131,15 +207661,15 @@ }, { "sim":178.0, - "partner":"1ejl" + "partner":"4yi0" }, { "sim":178.0, - "partner":"4yi0" + "partner":"3knd" }, { "sim":178.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":178.0, @@ -207151,11 +207681,11 @@ }, { "sim":178.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":178.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":178.0, @@ -207163,7 +207693,11 @@ }, { "sim":178.0, - "partner":"3zir" + "partner":"3q5u" + }, + { + "sim":178.0, + "partner":"5wum" }, { "sim":178.0, @@ -207185,6 +207719,10 @@ "sim":178.0, "partner":"3ziq" }, + { + "sim":178.0, + "partner":"3zir" + }, { "sim":178.0, "partner":"4uaf" @@ -207221,10 +207759,6 @@ "sim":178.0, "partner":"4ba3" }, - { - "sim":178.0, - "partner":"4htv" - }, { "sim":178.0, "partner":"4mz5" @@ -207235,15 +207769,7 @@ }, { "sim":178.0, - "partner":"3rzx" - }, - { - "sim":178.0, - "partner":"5e6q" - }, - { - "sim":178.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":178.0, @@ -207301,6 +207827,18 @@ "sim":178.0, "partner":"5klt" }, + { + "sim":178.0, + "partner":"3rzx" + }, + { + "sim":178.0, + "partner":"5e6q" + }, + { + "sim":178.0, + "partner":"3oqs" + }, { "sim":178.0, "partner":"5huw" @@ -207361,7 +207899,7 @@ ], "seq_max_sim_designed":{ "sim":538.0, - "partner":"5mfh" + "partner":"5aei" }, "seq_max_sim_natural":{ "sim":538.0, @@ -207439,104 +207977,104 @@ ], "subtitle":"Designed armadillo repeat protein yiiim3aiii", "tags":[ - "designed armadillo repeat protein", + "de novo protein", "peptide binding", - "de novo protein" + "designed armadillo repeat protein" ], "keywords":[ + "repeats", + "suitability", + "recognition", + "optimized", + "structural", "interfere", - "analysis", - "geometrically", - "matches", - "thus", - "close", - "chosen", - "scaffolds", - "peptide", - "designed", - "lattice", - "crystal", - "determined", - "target", - "show", - "technology", - "hand", + "development", "repeat", - "computationally", - "fret", - "turned", - "armrps", - "darmrp", - "induce", - "proteins", + "show", + "intention", + "side", + "within", + "ligands", + "parameters", + "adopted", + "protein", + "study", + "binding", + "continuous", + "close", + "essential", + "confirmed", "reality", - "prerequisite", - "small", - "binders", - "recognition", + "armrps", + "two", + "crystal", "binds", - "darmrps", + "chains", + "optimal", + "induce", + "shows", + "divergent", + "computationally", "furthermore", - "structures", - "essential", - "solution", - "suitable", "armadillo", - "exhibit", - "ligands", - "shows", - "suitability", - "consensus", - "previously", - "deviations", - "large", - "optimally", - "geometry", - "intention", - "continuous", - "corroborates", "define", - "divergent", - "optimal", - "12", + "thus", + "residues", + "matches", + "proteins", + "large", + "hand", + "accuracy", + "end", + "consensus", + "modular", + "scaffold", + "small", "bond", - "required", - "high", - "repeats", - "parameters", "unpublished", + "required", + "peptide", + "set", + "curvature", + "12", + "exhibit", + "optimally", + "length", + "fit", + "binders", + "experiments", + "chosen", + "solution", "formation", - "adopted", - "structural", + "backbone", + "technology", + "developed", + "geometrically", "range", - "accuracy", - "chains", - "optimized", - "study", - "length", + "turned", "desired", - "experiments", - "modular", - "confirmed", - "residues", - "two", - "evaluation", - "set", - "scaffold", - "significant", - "protein", + "fret", + "designed", + "analysis", + "corroborates", "calculate", - "backbone", - "development", - "end", - "fit", - "within", - "curvature", - "side", + "evaluation", + "geometry", + "structures", + "suitable", + "previously", + "deviations", + "scaffolds", + "determined", + "target", "curvatures", - "binding", - "developed", - "create" + "darmrps", + "lattice", + "high", + "prerequisite", + "darmrp", + "create", + "significant" ], "release_date":"2017-09-13", "publication":"\"Curvature of designed armadillo repeat proteins allows modular peptide binding\", J. Struct. Biol., 201, 108-117", @@ -207577,11 +208115,11 @@ }, { "sim":349.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":349.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":349.0, @@ -207593,11 +208131,11 @@ }, { "sim":349.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":349.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":344.0, @@ -207669,11 +208207,11 @@ }, { "sim":256.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":256.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":247.0, @@ -207751,15 +208289,15 @@ }, { "sim":137.0, - "partner":"4pvz" + "partner":"1bk5" }, { "sim":137.0, - "partner":"1bk5" + "partner":"1bk6" }, { "sim":137.0, - "partner":"1bk6" + "partner":"4pvz" }, { "sim":137.0, @@ -207799,15 +208337,15 @@ }, { "sim":134.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":134.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":134.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":134.0, @@ -207841,10 +208379,6 @@ "sim":124.0, "partner":"4u54" }, - { - "sim":124.0, - "partner":"4u5o" - }, { "sim":124.0, "partner":"3ve6" @@ -207873,6 +208407,10 @@ "sim":124.0, "partner":"4u5n" }, + { + "sim":124.0, + "partner":"4u5o" + }, { "sim":124.0, "partner":"3l3q" @@ -207887,11 +208425,11 @@ }, { "sim":124.0, - "partner":"1y2a" + "partner":"4zdu" }, { "sim":124.0, - "partner":"4zdu" + "partner":"1y2a" }, { "sim":124.0, @@ -207901,10 +208439,6 @@ "sim":124.0, "partner":"1ial" }, - { - "sim":124.0, - "partner":"3zir" - }, { "sim":124.0, "partner":"2ynr" @@ -207926,16 +208460,12 @@ "partner":"3ziq" }, { - "sim":123.0, - "partner":"5k9s" - }, - { - "sim":123.0, - "partner":"3q5u" + "sim":124.0, + "partner":"3zir" }, { "sim":123.0, - "partner":"5wum" + "partner":"5k9s" }, { "sim":123.0, @@ -207951,15 +208481,15 @@ }, { "sim":123.0, - "partner":"1ejl" + "partner":"4yi0" }, { "sim":123.0, - "partner":"4yi0" + "partner":"3knd" }, { "sim":123.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":123.0, @@ -207971,16 +208501,24 @@ }, { "sim":123.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":123.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":123.0, "partner":"1pjn" }, + { + "sim":123.0, + "partner":"3q5u" + }, + { + "sim":123.0, + "partner":"5wum" + }, { "sim":123.0, "partner":"4uaf" @@ -208001,10 +208539,6 @@ "sim":123.0, "partner":"4ba3" }, - { - "sim":123.0, - "partner":"4htv" - }, { "sim":123.0, "partner":"4mz5" @@ -208015,15 +208549,7 @@ }, { "sim":123.0, - "partner":"3rzx" - }, - { - "sim":123.0, - "partner":"5e6q" - }, - { - "sim":123.0, - "partner":"3oqs" + "partner":"4htv" }, { "sim":123.0, @@ -208081,6 +208607,18 @@ "sim":123.0, "partner":"5klt" }, + { + "sim":123.0, + "partner":"3rzx" + }, + { + "sim":123.0, + "partner":"5e6q" + }, + { + "sim":123.0, + "partner":"3oqs" + }, { "sim":123.0, "partner":"5huw" @@ -208212,85 +208750,85 @@ ], "subtitle":"Structure of the engineered metalloesterase mid1sc10 complexed with a phosphonate transition state analogue", "tags":[ - "de novo protein\/hydrolase", "engineered metalloenzyme", + "de novo protein-hydrolase", + "de novo protein\/hydrolase", "de novo protein-hydrolase complex", - "directed evolution", - "de novo protein-hydrolase" + "directed evolution" ], "keywords":[ - "laboratory", - "plausible", - "templated", - "early", - "might", - "evolution", - "k", - "imply", - "cleavage", - "recapitulating", - "past", - "exciting", - "proteins", - "pathway", - "unique", - "chemical", - "also", - "combined", - "although", + "seldom", + "reactivity", + "enantiospecificity", + "cat", + "na\u00efve", + "engineering", + "adopt", + "design", + "transform", "metal", - "ions", + "6", + "proffers", "origins", - "globular", + "structures", + "past", + "simple", "modern", - "enantiospecificity", - "catalytic", + "opportunities", + "illustrates", + "assembly", + "structure", + "might", + "although", + "short", "ester", - "peptide", - "reactivity", - "enzyme", - "peptides", - "accelerating", - "cat", - "6", + "scenario", + "also", + "exacting", + "useful", + "primordial", + "globular", "optimization", - "10", "imparted", - "short", - "useful", - "simple", + "tracing", + "combined", + "function", + "proteins", + "biogenetic", + "accelerating", + "simultaneous", "capable", + "ions", + "templated", + "cleavage", "ancestral", - "exacting", - "back", - "folds", - "evolutionary", - "proffers", - "engineering", + "plausible", + "high", "scaffold", - "na\u00efve", - "design", + "sequence", + "enzyme", + "early", + "pathway", + "imply", + "peptides", + "laboratory", + "exciting", + "signatures", + "catalytic", + "evolution", "efficiency", - "structures", - "primordial", - "adopt", - "distant", "present", + "chemical", + "k", + "distant", + "unique", "future", - "transform", - "assembly", - "sequence", - "high", - "simultaneous", - "structure", - "function", - "scenario", - "biogenetic", - "illustrates", - "seldom", - "tracing", - "opportunities", - "signatures" + "recapitulating", + "10", + "folds", + "peptide", + "back", + "evolutionary" ], "release_date":"2018-12-12", "publication":"\"Evolution of a highly active and enantiospecific metalloenzyme from short peptides\", Science, 362, 1285-1288", @@ -208333,17 +208871,13 @@ "sim":135.0, "partner":"7bww" }, - { - "sim":74.0, - "partner":"3v1d" - }, { "sim":74.0, "partner":"3v1c" }, { "sim":74.0, - "partner":"3v1b" + "partner":"3v1d" }, { "sim":74.0, @@ -208353,6 +208887,10 @@ "sim":74.0, "partner":"3v1a" }, + { + "sim":74.0, + "partner":"3v1b" + }, { "sim":71.0, "partner":"3v1f" @@ -208454,83 +208992,83 @@ ], "subtitle":"Structure of the engineered metalloesterase mid1sc9", "tags":[ - "engineered metalloenzyme", "directed evolution", + "engineered metalloenzyme", "de novo protein hydrolase" ], "keywords":[ - "laboratory", - "plausible", - "templated", - "early", - "might", - "evolution", - "k", - "imply", - "cleavage", - "recapitulating", - "past", - "exciting", - "proteins", - "pathway", - "unique", - "chemical", - "also", - "combined", - "although", + "seldom", + "reactivity", + "enantiospecificity", + "cat", + "na\u00efve", + "engineering", + "adopt", + "design", + "transform", "metal", - "ions", + "6", + "proffers", "origins", - "globular", + "structures", + "past", + "simple", "modern", - "enantiospecificity", - "catalytic", + "opportunities", + "illustrates", + "assembly", + "structure", + "might", + "although", + "short", "ester", - "peptide", - "reactivity", - "enzyme", - "peptides", - "accelerating", - "cat", - "6", + "scenario", + "also", + "exacting", + "useful", + "primordial", + "globular", "optimization", - "10", "imparted", - "short", - "useful", - "simple", + "tracing", + "combined", + "function", + "proteins", + "biogenetic", + "accelerating", + "simultaneous", "capable", + "ions", + "templated", + "cleavage", "ancestral", - "exacting", - "back", - "folds", - "evolutionary", - "proffers", - "engineering", + "plausible", + "high", "scaffold", - "na\u00efve", - "design", + "sequence", + "enzyme", + "early", + "pathway", + "imply", + "peptides", + "laboratory", + "exciting", + "signatures", + "catalytic", + "evolution", "efficiency", - "structures", - "primordial", - "adopt", - "distant", "present", + "chemical", + "k", + "distant", + "unique", "future", - "transform", - "assembly", - "sequence", - "high", - "simultaneous", - "structure", - "function", - "scenario", - "biogenetic", - "illustrates", - "seldom", - "tracing", - "opportunities", - "signatures" + "recapitulating", + "10", + "folds", + "peptide", + "back", + "evolutionary" ], "release_date":"2018-12-12", "publication":"\"Evolution of a highly active and enantiospecific metalloenzyme from short peptides\", Science, 362, 1285-1288", @@ -208573,17 +209111,13 @@ "sim":133.0, "partner":"7bww" }, - { - "sim":79.0, - "partner":"3v1d" - }, { "sim":79.0, "partner":"3v1c" }, { "sim":79.0, - "partner":"3v1b" + "partner":"3v1d" }, { "sim":79.0, @@ -208593,6 +209127,10 @@ "sim":79.0, "partner":"3v1a" }, + { + "sim":79.0, + "partner":"3v1b" + }, { "sim":76.0, "partner":"3v1f" @@ -208662,10 +209200,10 @@ ], "subtitle":"Designed ankyrin repeat protein (darpin) ytrl-2 selected by directed evolution against lysozyme", "tags":[ - "darpin", + "designed protein", "de novo protein", "directed evolution", - "designed protein" + "darpin" ], "keywords":[ "description", @@ -208710,19 +209248,19 @@ }, { "sim":297.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":297.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":297.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":297.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":297.0, @@ -208730,35 +209268,35 @@ }, { "sim":297.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":297.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":297.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":297.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":297.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":297.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":297.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":297.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":291.0, @@ -208766,11 +209304,11 @@ }, { "sim":289.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":289.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":285.0, @@ -208890,7 +209428,7 @@ }, { "sim":258.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":258.0, @@ -208898,7 +209436,7 @@ }, { "sim":258.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":257.0, @@ -208974,11 +209512,11 @@ }, { "sim":219.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":219.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":219.0, @@ -209010,11 +209548,11 @@ }, { "sim":197.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":197.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":196.0, @@ -209028,6 +209566,10 @@ "sim":186.0, "partner":"8aiw" }, + { + "sim":184.0, + "partner":"9glq" + }, { "sim":181.0, "partner":"4hqd" @@ -209082,10 +209624,6 @@ "sim":300.0, "partner":"5ooy" }, - { - "sim":297.0, - "partner":"5oyj" - }, { "sim":297.0, "partner":"5nqt" @@ -209114,6 +209652,10 @@ "sim":297.0, "partner":"4hna" }, + { + "sim":297.0, + "partner":"5oyj" + }, { "sim":293.0, "partner":"3zu7" @@ -209130,10 +209672,6 @@ "sim":292.0, "partner":"5eib" }, - { - "sim":291.0, - "partner":"5eno" - }, { "sim":291.0, "partner":"4dx6" @@ -209206,6 +209744,10 @@ "sim":291.0, "partner":"4dx5" }, + { + "sim":291.0, + "partner":"5eno" + }, { "sim":290.0, "partner":"5eyl" @@ -209324,11 +209866,11 @@ }, { "sim":260.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":260.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":260.0, @@ -209380,11 +209922,11 @@ }, { "sim":242.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":242.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":241.0, @@ -209506,10 +210048,6 @@ "sim":109.0, "partner":"5y4f" }, - { - "sim":107.0, - "partner":"5vhj" - }, { "sim":107.0, "partner":"5vhh" @@ -209538,6 +210076,10 @@ "sim":107.0, "partner":"5vho" }, + { + "sim":107.0, + "partner":"5vhj" + }, { "sim":107.0, "partner":"5vhp" @@ -209564,23 +210106,23 @@ }, { "sim":106.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":106.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":106.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":104.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":104.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":104.0, @@ -209640,15 +210182,15 @@ }, { "sim":95.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":95.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":95.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":94.0, @@ -209886,10 +210428,6 @@ "sim":77.0, "partner":"5wo6" }, - { - "sim":77.0, - "partner":"5iwr" - }, { "sim":77.0, "partner":"5iwt" @@ -209938,6 +210476,10 @@ "sim":77.0, "partner":"5iwp" }, + { + "sim":77.0, + "partner":"5iwr" + }, { "sim":77.0, "partner":"5wo7" @@ -209948,15 +210490,15 @@ }, { "sim":76.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":76.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":76.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":76.0, @@ -210010,10 +210552,6 @@ "sim":68.0, "partner":"6e2f" }, - { - "sim":68.0, - "partner":"6bo9" - }, { "sim":68.0, "partner":"6boa" @@ -210030,6 +210568,10 @@ "sim":68.0, "partner":"6bo8" }, + { + "sim":68.0, + "partner":"6bo9" + }, { "sim":66.0, "partner":"3deo" @@ -210251,10 +210793,10 @@ ], "subtitle":"Designed ankyrin repeat protein (darpin) ytrl-1 selected by directed evolution against lysozyme", "tags":[ - "darpin", + "designed protein", "de novo protein", "directed evolution", - "designed protein" + "darpin" ], "keywords":[ "description", @@ -210303,27 +210845,27 @@ }, { "sim":293.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":293.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":291.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":291.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":291.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":291.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":291.0, @@ -210331,35 +210873,35 @@ }, { "sim":291.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":291.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":291.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":291.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":291.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":291.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":291.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":291.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":287.0, @@ -210487,7 +211029,7 @@ }, { "sim":256.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":256.0, @@ -210495,7 +211037,7 @@ }, { "sim":256.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":255.0, @@ -210563,11 +211105,11 @@ }, { "sim":224.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":224.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":224.0, @@ -210595,11 +211137,11 @@ }, { "sim":198.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":198.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":197.0, @@ -210617,6 +211159,10 @@ "sim":185.0, "partner":"8aiw" }, + { + "sim":183.0, + "partner":"9glq" + }, { "sim":182.0, "partner":"4hqd" @@ -210683,10 +211229,6 @@ "sim":296.0, "partner":"4hna" }, - { - "sim":295.0, - "partner":"5eno" - }, { "sim":295.0, "partner":"4dx6" @@ -210763,6 +211305,10 @@ "sim":295.0, "partner":"4dx5" }, + { + "sim":295.0, + "partner":"5eno" + }, { "sim":293.0, "partner":"5oyj" @@ -210929,11 +211475,11 @@ }, { "sim":257.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":257.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":257.0, @@ -210973,11 +211519,11 @@ }, { "sim":241.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":241.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":240.0, @@ -211095,17 +211641,13 @@ "sim":108.0, "partner":"2l6b" }, - { - "sim":102.0, - "partner":"4cym" - }, { "sim":102.0, "partner":"4cz2" }, { "sim":102.0, - "partner":"5vhj" + "partner":"4cym" }, { "sim":102.0, @@ -211135,6 +211677,10 @@ "sim":102.0, "partner":"5vho" }, + { + "sim":102.0, + "partner":"5vhj" + }, { "sim":102.0, "partner":"5vhp" @@ -211495,10 +212041,6 @@ "sim":72.0, "partner":"5wo6" }, - { - "sim":72.0, - "partner":"5iwr" - }, { "sim":72.0, "partner":"5iwt" @@ -211547,17 +212089,21 @@ "sim":72.0, "partner":"5iwp" }, + { + "sim":72.0, + "partner":"5iwr" + }, { "sim":72.0, "partner":"5wo7" }, { "sim":71.0, - "partner":"1d9s" + "partner":"8pef" }, { "sim":71.0, - "partner":"8pef" + "partner":"1d9s" }, { "sim":71.0, @@ -211565,15 +212111,15 @@ }, { "sim":70.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":70.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":70.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":70.0, @@ -211631,10 +212177,6 @@ "sim":65.0, "partner":"6e2f" }, - { - "sim":65.0, - "partner":"6bo9" - }, { "sim":65.0, "partner":"6boa" @@ -211651,6 +212193,10 @@ "sim":65.0, "partner":"6bo8" }, + { + "sim":65.0, + "partner":"6bo9" + }, { "sim":64.0, "partner":"2fo1" @@ -211749,11 +212295,11 @@ ], "subtitle":"Designed ankyrin repeat protein (darpin) ndnh-1 selected by directed evolution against lysozyme", "tags":[ + "darpin", "de novo protein", "directed evolution", "designed protein", - "transport protein", - "darpin" + "transport protein" ], "keywords":[ "description", @@ -211810,19 +212356,19 @@ }, { "sim":290.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":290.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":290.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":290.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":290.0, @@ -211830,35 +212376,35 @@ }, { "sim":290.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":290.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":290.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":290.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":290.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":290.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":290.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":290.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":289.0, @@ -211878,11 +212424,11 @@ }, { "sim":282.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":282.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":280.0, @@ -211934,7 +212480,7 @@ }, { "sim":265.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":265.0, @@ -211942,7 +212488,7 @@ }, { "sim":265.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":264.0, @@ -211998,11 +212544,11 @@ }, { "sim":252.0, - "partner":"7zyu" + "partner":"7z7c" }, { "sim":252.0, - "partner":"7z7c" + "partner":"7zyu" }, { "sim":251.0, @@ -212058,11 +212604,11 @@ }, { "sim":223.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":223.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":223.0, @@ -212094,11 +212640,11 @@ }, { "sim":196.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":196.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":195.0, @@ -212128,6 +212674,10 @@ "sim":180.0, "partner":"5kba" }, + { + "sim":179.0, + "partner":"9glq" + }, { "sim":177.0, "partner":"4gpm" @@ -212234,10 +212784,6 @@ "sim":286.0, "partner":"5eib" }, - { - "sim":284.0, - "partner":"5eno" - }, { "sim":284.0, "partner":"4dx6" @@ -212310,6 +212856,10 @@ "sim":284.0, "partner":"4dx5" }, + { + "sim":284.0, + "partner":"5eno" + }, { "sim":283.0, "partner":"5eyl" @@ -212408,11 +212958,11 @@ }, { "sim":261.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":261.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":261.0, @@ -212484,11 +213034,11 @@ }, { "sim":233.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":233.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":227.0, @@ -212644,11 +213194,11 @@ }, { "sim":105.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":105.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":104.0, @@ -212662,10 +213212,6 @@ "sim":103.0, "partner":"3b7b" }, - { - "sim":102.0, - "partner":"5vhj" - }, { "sim":102.0, "partner":"5vhh" @@ -212694,6 +213240,10 @@ "sim":102.0, "partner":"5vho" }, + { + "sim":102.0, + "partner":"5vhj" + }, { "sim":102.0, "partner":"5vhp" @@ -212720,15 +213270,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":101.0, @@ -213026,10 +213576,6 @@ "sim":76.0, "partner":"5wo6" }, - { - "sim":76.0, - "partner":"5iwr" - }, { "sim":76.0, "partner":"5iwt" @@ -213078,6 +213624,10 @@ "sim":76.0, "partner":"5iwp" }, + { + "sim":76.0, + "partner":"5iwr" + }, { "sim":76.0, "partner":"5wo7" @@ -213100,15 +213650,15 @@ }, { "sim":74.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":74.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":74.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":74.0, @@ -213144,11 +213694,11 @@ }, { "sim":69.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":69.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":68.0, @@ -213162,10 +213712,6 @@ "sim":68.0, "partner":"6e2f" }, - { - "sim":68.0, - "partner":"6bo9" - }, { "sim":68.0, "partner":"6boa" @@ -213182,6 +213728,10 @@ "sim":68.0, "partner":"6bo8" }, + { + "sim":68.0, + "partner":"6bo9" + }, { "sim":66.0, "partner":"1k3z" @@ -213475,80 +214025,80 @@ ], "subtitle":"Crystal structure of designed cppr-telo1", "tags":[ + "telomerase", "de novo protein", "designer nucleic acid-binding proteins", - "pentatricopeptide repeat", - "telomerase" + "pentatricopeptide repeat" ], "keywords":[ - "ppr", - "double", - "pentatricopeptide", - "importance", - "strands", - "telomerase", - "separated", - "proteins", - "available", + "designed", + "repair", + "typically", + "finally", + "engineered", + "design", + "however", "specificity", + "show", + "repeat", "must", + "provides", + "structures", + "single", + "understand", + "rna", "dna", + "rearrangements", + "enabled", + "structure", + "helix", "revealing", - "telomeric", - "rna", - "single", - "repair", "although", - "tools", - "artificial", - "including", - "understand", - "typically", - "finally", - "replication", - "modular", - "programmed", + "block", + "telomerase", + "pprs", "code", - "enable", - "engineered", - "designed", - "mode", - "found", - "envelope", - "rearrangements", - "activity", - "currently", - "apo", "target", - "provides", - "hydrogen", - "show", - "design", + "occur", + "ppr", + "interactions", + "telomeric", "basis", - "transcription", + "bind", + "proteins", + "mode", + "binding", + "programmed", + "metabolism", "ssdna", - "interactions", - "occur", - "using", - "structures", + "artificial", + "pentatricopeptide", + "strands", + "phases", + "enable", + "modular", + "activity", + "cells", + "transcription", + "hydrogen", + "manipulate", + "available", + "apo", + "found", "bond", - "bind", "recent", - "helix", + "currently", "breakthroughs", - "structure", - "repeat", - "block", - "phases", - "metabolism", + "separated", "recombination", - "enabled", - "however", - "solve", - "cells", - "manipulate", - "binding", - "pprs" + "using", + "envelope", + "double", + "importance", + "tools", + "including", + "replication", + "solve" ], "release_date":"2018-06-20", "publication":"\"Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins\", Nat Commun, 9, 2212-2212", @@ -213745,23 +214295,23 @@ "seq_thr_sim_designed":[ { "sim":65.0, - "partner":"5sbj" + "partner":"9g3c" }, { "sim":65.0, - "partner":"9g3b" + "partner":"9g3a" }, { "sim":65.0, - "partner":"5sbi" + "partner":"9g39" }, { "sim":65.0, - "partner":"9g3c" + "partner":"5sbj" }, { "sim":65.0, - "partner":"9g39" + "partner":"9g3b" }, { "sim":65.0, @@ -213769,7 +214319,7 @@ }, { "sim":65.0, - "partner":"9g3a" + "partner":"5sbi" } ], "seq_thr_sim_natural":[ @@ -213810,7 +214360,7 @@ ], "seq_max_sim_designed":{ "sim":65.0, - "partner":"5sbj" + "partner":"9g3c" }, "seq_max_sim_natural":[ @@ -213896,15 +214446,15 @@ "seq_thr_sim_designed":[ { "sim":65.0, - "partner":"5sbj" + "partner":"9g3c" }, { "sim":65.0, - "partner":"9g3b" + "partner":"5sbg" }, { "sim":65.0, - "partner":"9g3c" + "partner":"9g3a" }, { "sim":65.0, @@ -213912,15 +214462,15 @@ }, { "sim":65.0, - "partner":"9g3u" + "partner":"5sbj" }, { "sim":65.0, - "partner":"9g3a" + "partner":"9g3b" }, { "sim":65.0, - "partner":"5sbg" + "partner":"9g3u" } ], "seq_thr_sim_natural":[ @@ -213961,7 +214511,7 @@ ], "seq_max_sim_designed":{ "sim":65.0, - "partner":"5sbj" + "partner":"9g3c" }, "seq_max_sim_natural":[ @@ -214047,15 +214597,15 @@ "seq_thr_sim_designed":[ { "sim":65.0, - "partner":"9g3b" + "partner":"9g3c" }, { "sim":65.0, - "partner":"5sbi" + "partner":"5sbg" }, { "sim":65.0, - "partner":"9g3c" + "partner":"9g3a" }, { "sim":65.0, @@ -214063,15 +214613,15 @@ }, { "sim":65.0, - "partner":"9g3u" + "partner":"9g3b" }, { "sim":65.0, - "partner":"9g3a" + "partner":"9g3u" }, { "sim":65.0, - "partner":"5sbg" + "partner":"5sbi" } ], "seq_thr_sim_natural":[ @@ -214112,7 +214662,7 @@ ], "seq_max_sim_designed":{ "sim":65.0, - "partner":"9g3b" + "partner":"9g3c" }, "seq_max_sim_natural":[ @@ -214190,56 +214740,56 @@ ], "subtitle":"Nmr structure of apo-ps1", "tags":[ - "unknown function", "4-helix bundle", - "coiled-coil" + "coiled-coil", + "unknown function" ], "keywords":[ - "100", - "predetermined", + "orchestration", "substrates", - "ligand", - "chains", - "demonstrated", - "results", - "entirely", + "central", + "design", "geometry", + "principles", + "agreement", + "yet", + "first", + "core", + "retains", + "side", + "ligand", + "structure", "report", - "orchestration", - "holoprotein", - "porphyrin", + "results", "flexible", - "principle", - "desired", - "temperatures", + "cofactors", + "precisely", + "unification", + "protein", "illustrate", + "packing", + "binding", + "ability", + "entirely", "requires", + "demonstrated", "highly", - "yet", - "agreement", - "cofactors", - "binds", - "precisely", + "definition", + "principle", + "predetermined", "region", - "ability", - "remote", - "central", - "design", - "core", - "binding", - "protein", "predisposed", - "structure", - "definition", - "principles", - "side", - "first", + "porphyrin", + "binds", + "chains", + "temperatures", + "desired", + "100", + "remote", + "catalysis", "novel", "ps1", - "catalysis", - "retains", - "packing", - "unification" + "holoprotein" ], "release_date":"2017-08-09", "publication":"\"De novo design of a hyperstable non-natural protein-ligand complex with sub- angstrom accuracy\", Nat Chem, 9, 1157-1164", @@ -214358,57 +214908,57 @@ ], "subtitle":"Nmr structure of holo-ps1", "tags":[ - "unknown function", "4-helix bundle", "coiled-coil", + "unknown function", "holoprotein" ], "keywords":[ - "100", - "predetermined", + "orchestration", "substrates", - "ligand", - "chains", - "demonstrated", - "results", - "entirely", + "central", + "design", "geometry", + "principles", + "agreement", + "yet", + "first", + "core", + "retains", + "side", + "ligand", + "structure", "report", - "orchestration", - "holoprotein", - "porphyrin", + "results", "flexible", - "principle", - "desired", - "temperatures", + "cofactors", + "precisely", + "unification", + "protein", "illustrate", + "packing", + "binding", + "ability", + "entirely", "requires", + "demonstrated", "highly", - "yet", - "agreement", - "cofactors", - "binds", - "precisely", + "definition", + "principle", + "predetermined", "region", - "ability", - "remote", - "central", - "design", - "core", - "binding", - "protein", "predisposed", - "structure", - "definition", - "principles", - "side", - "first", + "porphyrin", + "binds", + "chains", + "temperatures", + "desired", + "100", + "remote", + "catalysis", "novel", "ps1", - "catalysis", - "retains", - "packing", - "unification" + "holoprotein" ], "release_date":"2017-08-09", "publication":"\"De novo design of a hyperstable non-natural protein-ligand complex with sub- angstrom accuracy\", Nat Chem, 9, 1157-1164", @@ -214559,66 +215109,66 @@ "de novo ntf2" ], "keywords":[ - "series", - "sites", - "topped", - "accuracy", - "toward", - "control", + "curvature", + "simulations", "analysis", - "designs", - "\u03b2", - "magnetic", - "proteins", - "models", - "helices", - "investigated", "enables", - "geometry", - "showing", - "approach", - "customized", - "de", - "novo", - "route", - "catalytic", + "often", + "models", "allow", - "would", - "controlled", + "design", + "naturally", "curved", - "used", + "cavities", + "mechanisms", + "investigated", + "controlled", "custom", + "geometry", + "formed", + "principles", "active", - "closely", - "specific", - "simulations", - "nuclear", - "studying", - "crystal", - "often", - "ability", - "occurring", "provides", - "match", - "sheets", - "design", - "controlling", "structures", - "naturally", + "used", + "de", + "topped", + "\u03b2", + "specific", + "route", + "ligands", + "folding", + "closely", + "control", "protein", + "magnetic", + "controlling", + "approach", + "showing", + "sites", + "proteins", + "would", + "binding", + "accuracy", + "sheets", "\u03b1", - "mechanisms", "end", - "cavities", - "resonance", + "ability", + "series", + "novo", "native", - "ligands", - "curvature", + "resonance", + "match", + "customized", + "catalytic", + "toward", + "nuclear", + "crystal", + "helices", + "studying", + "designs", "computational", - "principles", - "folding", - "binding", - "formed", + "occurring", "emerging" ], "release_date":"2017-01-25", @@ -214788,66 +215338,66 @@ "de novo ntf2" ], "keywords":[ - "series", - "sites", - "topped", - "accuracy", - "toward", - "control", + "curvature", + "simulations", "analysis", - "designs", - "\u03b2", - "magnetic", - "proteins", - "models", - "helices", - "investigated", "enables", - "geometry", - "showing", - "approach", - "customized", - "de", - "novo", - "route", - "catalytic", + "often", + "models", "allow", - "would", - "controlled", + "design", + "naturally", "curved", - "used", + "cavities", + "mechanisms", + "investigated", + "controlled", "custom", + "geometry", + "formed", + "principles", "active", - "closely", - "specific", - "simulations", - "nuclear", - "studying", - "crystal", - "often", - "ability", - "occurring", "provides", - "match", - "sheets", - "design", - "controlling", "structures", - "naturally", + "used", + "de", + "topped", + "\u03b2", + "specific", + "route", + "ligands", + "folding", + "closely", + "control", "protein", + "magnetic", + "controlling", + "approach", + "showing", + "sites", + "proteins", + "would", + "binding", + "accuracy", + "sheets", "\u03b1", - "mechanisms", "end", - "cavities", - "resonance", + "ability", + "series", + "novo", "native", - "ligands", - "curvature", + "resonance", + "match", + "customized", + "catalytic", + "toward", + "nuclear", + "crystal", + "helices", + "studying", + "designs", "computational", - "principles", - "folding", - "binding", - "formed", + "occurring", "emerging" ], "release_date":"2017-01-25", @@ -215021,66 +215571,66 @@ "de novo ntf2" ], "keywords":[ - "series", - "sites", - "topped", - "accuracy", - "toward", - "control", + "curvature", + "simulations", "analysis", - "designs", - "\u03b2", - "magnetic", - "proteins", - "models", - "helices", - "investigated", "enables", - "geometry", - "showing", - "approach", - "customized", - "de", - "novo", - "route", - "catalytic", + "often", + "models", "allow", - "would", - "controlled", + "design", + "naturally", "curved", - "used", + "cavities", + "mechanisms", + "investigated", + "controlled", "custom", + "geometry", + "formed", + "principles", "active", - "closely", - "specific", - "simulations", - "nuclear", - "studying", - "crystal", - "often", - "ability", - "occurring", "provides", - "match", - "sheets", - "design", - "controlling", "structures", - "naturally", + "used", + "de", + "topped", + "\u03b2", + "specific", + "route", + "ligands", + "folding", + "closely", + "control", "protein", + "magnetic", + "controlling", + "approach", + "showing", + "sites", + "proteins", + "would", + "binding", + "accuracy", + "sheets", "\u03b1", - "mechanisms", "end", - "cavities", - "resonance", + "ability", + "series", + "novo", "native", - "ligands", - "curvature", + "resonance", + "match", + "customized", + "catalytic", + "toward", + "nuclear", + "crystal", + "helices", + "studying", + "designs", "computational", - "principles", - "folding", - "binding", - "formed", + "occurring", "emerging" ], "release_date":"2017-01-25", @@ -215258,66 +215808,66 @@ "de novo ntf2" ], "keywords":[ - "series", - "sites", - "topped", - "accuracy", - "toward", - "control", + "curvature", + "simulations", "analysis", - "designs", - "\u03b2", - "magnetic", - "proteins", - "models", - "helices", - "investigated", "enables", - "geometry", - "showing", - "approach", - "customized", - "de", - "novo", - "route", - "catalytic", + "often", + "models", "allow", - "would", - "controlled", + "design", + "naturally", "curved", - "used", + "cavities", + "mechanisms", + "investigated", + "controlled", "custom", + "geometry", + "formed", + "principles", "active", - "closely", - "specific", - "simulations", - "nuclear", - "studying", - "crystal", - "often", - "ability", - "occurring", "provides", - "match", - "sheets", - "design", - "controlling", "structures", - "naturally", + "used", + "de", + "topped", + "\u03b2", + "specific", + "route", + "ligands", + "folding", + "closely", + "control", "protein", + "magnetic", + "controlling", + "approach", + "showing", + "sites", + "proteins", + "would", + "binding", + "accuracy", + "sheets", "\u03b1", - "mechanisms", "end", - "cavities", - "resonance", + "ability", + "series", + "novo", "native", - "ligands", - "curvature", + "resonance", + "match", + "customized", + "catalytic", + "toward", + "nuclear", + "crystal", + "helices", + "studying", + "designs", "computational", - "principles", - "folding", - "binding", - "formed", + "occurring", "emerging" ], "release_date":"2017-01-25", @@ -215454,103 +216004,103 @@ "de novo protein" ], "keywords":[ - "work", - "utilize", - "pharmacological", - "studies", - "bonds", - "label", - "reducing", - "designed", - "determine", - "broad", - "methods", - "potential", - "expression", - "conformation", - "adopt", - "assess", - "therefore", - "represent", - "structure", + "made", "escherichia", + "molecular", "redesign", - "uniformly", - "utility", + "adopt", + "unsuccessful", + "methods", + "therefore", + "well", + "tempering", + "families", + "13", + "assess", + "new", "unstable", - "simulation", - "models", - "exhibited", + "protein", + "vitro", + "novo", + "resonance", + "two", + "recent", + "nuclear", + "stable", + "using", + "utilize", + "needed", + "simulations", + "conformation", "enables", - "de", - "produce", - "family", - "used", - "dependency", - "agreed", "initial", - "nuclear", - "vitro", - "made", + "confirming", + "exhibited", "furthermore", - "md", - "production", - "dynamics", + "family", + "protocol", + "disulfide", + "magnetic", + "stability", "calculated", - "structures", - "attempts", + "uniformly", + "accuracy", + "broad", "advantage", - "tempering", - "solution", - "resonance", - "revealed", - "likely", - "performed", - "previously", - "stability", - "reported", - "data", - "molecular", - "conditions", - "coli", - "families", - "host", - "method", - "protocol", - "simulations", + "pharmacological", + "label", + "15", + "ensemble", + "reducing", + "computational", "advances", "design", - "using", - "nmr", - "confirming", - "recent", - "describe", - "techniques", - "ensemble", - "disulfide", + "work", + "used", + "represent", + "produce", + "possible", + "potential", + "fold", + "bonds", "collection", - "important", - "unsuccessful", - "13", - "accuracy", - "designs", + "solution", + "utility", + "conditions", + "coli", "maintain", - "magnetic", - "stable", - "novo", - "fold", - "peptides", - "well", - "needed", - "two", "system", + "reported", + "peptides", + "techniques", + "describe", + "determine", + "agreed", + "method", + "dynamics", + "production", + "designed", + "models", + "revealed", + "structures", + "de", + "previously", + "performed", + "attempts", + "likely", + "important", + "structure", + "host", + "nmr", "state", - "protein", - "15", + "dependency", + "md", "isotopically", - "computational", - "possible", - "new" + "expression", + "studies", + "data", + "designs", + "simulation" ], "release_date":"2017-09-27", "publication":"\"Cytosolic expression, solution structures, and molecular dynamics simulation of genetically encodable disulfide-rich de novo designed peptides\", Protein Sci., 27, 1611-1623", @@ -215703,66 +216253,66 @@ "de novo ntf2" ], "keywords":[ - "series", - "sites", - "topped", - "accuracy", - "toward", - "control", + "curvature", + "simulations", "analysis", - "designs", - "\u03b2", - "magnetic", - "proteins", - "models", - "helices", - "investigated", "enables", - "geometry", - "showing", - "approach", - "customized", - "de", - "novo", - "route", - "catalytic", + "often", + "models", "allow", - "would", - "controlled", + "design", + "naturally", "curved", - "used", + "cavities", + "mechanisms", + "investigated", + "controlled", "custom", + "geometry", + "formed", + "principles", "active", - "closely", - "specific", - "simulations", - "nuclear", - "studying", - "crystal", - "often", - "ability", - "occurring", "provides", - "match", - "sheets", - "design", - "controlling", "structures", - "naturally", + "used", + "de", + "topped", + "\u03b2", + "specific", + "route", + "ligands", + "folding", + "closely", + "control", "protein", + "magnetic", + "controlling", + "approach", + "showing", + "sites", + "proteins", + "would", + "binding", + "accuracy", + "sheets", "\u03b1", - "mechanisms", "end", - "cavities", - "resonance", + "ability", + "series", + "novo", "native", - "ligands", - "curvature", + "resonance", + "match", + "customized", + "catalytic", + "toward", + "nuclear", + "crystal", + "helices", + "studying", + "designs", "computational", - "principles", - "folding", - "binding", - "formed", + "occurring", "emerging" ], "release_date":"2017-01-25", @@ -215878,51 +216428,51 @@ ], "subtitle":"Coiled coil peptide metal coordination framework: dimer fold grown with citrate", "tags":[ - "metal coordination framework", - "designed peptide", "de novo protein", "synthetic", + "metal coordination framework", + "designed peptide", "supramolecular assembly" ], "keywords":[ - "general", "supramolecular", - "architectures", - "ligand", - "reveals", - "subtle", - "coordination", + "crystalline", "defined", - "report", - "cu", - "unnatural", "metal", + "structural", + "terpyridine", + "subtle", + "formed", + "methods", + "presence", + "ligand", + "based", + "assembly", + "cu", + "synthetic", + "report", + "new", + "architectures", "class", - "morphology", - "peptides", + "characterization", + "unnatural", + "coordination", "modular", - "presence", + "general", + "sequence", "proven", - "two", - "materials", - "methods", - "creating", + "reveals", "lattices", - "based", + "peptides", + "dictates", + "morphology", + "two", + "moieties", "mechanism", - "characterization", + "materials", "variation", - "synthetic", - "terpyridine", - "assembly", - "sequence", - "crystalline", "bearing", - "dictates", - "moieties", - "structural", - "formed", - "new" + "creating" ], "release_date":"2017-02-22", "publication":"\"Supramolecular Metal-Coordination Polymers, Nets, and Frameworks from Synthetic Coiled-Coil Peptides\", J. Am. Chem. Soc., 139, 2212-2215", @@ -216024,51 +216574,51 @@ ], "subtitle":"Coiled coil peptide metal coordination framework: dimer fold", "tags":[ - "metal coordination framework", - "designed peptide", "de novo protein", "synthetic", + "metal coordination framework", + "designed peptide", "supramolecular assembly" ], "keywords":[ - "general", "supramolecular", - "architectures", - "ligand", - "reveals", - "subtle", - "coordination", + "crystalline", "defined", - "report", - "cu", - "unnatural", "metal", + "structural", + "terpyridine", + "subtle", + "formed", + "methods", + "presence", + "ligand", + "based", + "assembly", + "cu", + "synthetic", + "report", + "new", + "architectures", "class", - "morphology", - "peptides", + "characterization", + "unnatural", + "coordination", "modular", - "presence", + "general", + "sequence", "proven", - "two", - "materials", - "methods", - "creating", + "reveals", "lattices", - "based", + "peptides", + "dictates", + "morphology", + "two", + "moieties", "mechanism", - "characterization", + "materials", "variation", - "synthetic", - "terpyridine", - "assembly", - "sequence", - "crystalline", "bearing", - "dictates", - "moieties", - "structural", - "formed", - "new" + "creating" ], "release_date":"2017-02-22", "publication":"\"Supramolecular Metal-Coordination Polymers, Nets, and Frameworks from Synthetic Coiled-Coil Peptides\", J. Am. Chem. Soc., 139, 2212-2215", @@ -216163,51 +216713,51 @@ ], "subtitle":"Coiled coil peptide metal coordination framework: trimer fold", "tags":[ - "metal coordination framework", - "designed peptide", "de novo protein", "synthetic", + "metal coordination framework", + "designed peptide", "supramolecular assembly" ], "keywords":[ - "general", "supramolecular", - "architectures", - "ligand", - "reveals", - "subtle", - "coordination", + "crystalline", "defined", - "report", - "cu", - "unnatural", "metal", + "structural", + "terpyridine", + "subtle", + "formed", + "methods", + "presence", + "ligand", + "based", + "assembly", + "cu", + "synthetic", + "report", + "new", + "architectures", "class", - "morphology", - "peptides", + "characterization", + "unnatural", + "coordination", "modular", - "presence", + "general", + "sequence", "proven", - "two", - "materials", - "methods", - "creating", + "reveals", "lattices", - "based", + "peptides", + "dictates", + "morphology", + "two", + "moieties", "mechanism", - "characterization", + "materials", "variation", - "synthetic", - "terpyridine", - "assembly", - "sequence", - "crystalline", "bearing", - "dictates", - "moieties", - "structural", - "formed", - "new" + "creating" ], "release_date":"2017-02-22", "publication":"\"Supramolecular Metal-Coordination Polymers, Nets, and Frameworks from Synthetic Coiled-Coil Peptides\", J. Am. Chem. Soc., 139, 2212-2215", @@ -216302,51 +216852,51 @@ ], "subtitle":"Coiled coil peptide metal coordination framework: tetramer fold", "tags":[ - "metal coordination framework", - "designed peptide", "de novo protein", "synthetic", + "metal coordination framework", + "designed peptide", "supramolecular assembly" ], "keywords":[ - "general", "supramolecular", - "architectures", - "ligand", - "reveals", - "subtle", - "coordination", + "crystalline", "defined", - "report", - "cu", - "unnatural", "metal", + "structural", + "terpyridine", + "subtle", + "formed", + "methods", + "presence", + "ligand", + "based", + "assembly", + "cu", + "synthetic", + "report", + "new", + "architectures", "class", - "morphology", - "peptides", + "characterization", + "unnatural", + "coordination", "modular", - "presence", + "general", + "sequence", "proven", - "two", - "materials", - "methods", - "creating", + "reveals", "lattices", - "based", + "peptides", + "dictates", + "morphology", + "two", + "moieties", "mechanism", - "characterization", + "materials", "variation", - "synthetic", - "terpyridine", - "assembly", - "sequence", - "crystalline", "bearing", - "dictates", - "moieties", - "structural", - "formed", - "new" + "creating" ], "release_date":"2017-02-22", "publication":"\"Supramolecular Metal-Coordination Polymers, Nets, and Frameworks from Synthetic Coiled-Coil Peptides\", J. Am. Chem. Soc., 139, 2212-2215", @@ -216399,14 +216949,14 @@ "sim":0.9700000286, "partner":"3r3k" }, - { - "sim":0.9631999731, - "partner":"3r47" - }, { "sim":0.9679999948, "partner":"3r4h" }, + { + "sim":0.9631999731, + "partner":"3r47" + }, { "sim":0.961499989, "partner":"5eon" @@ -216484,116 +217034,116 @@ ], "subtitle":"The tris-thiolate zn(ii)s3cl binding site engineered by d-cysteine ligands in de novo three-stranded coiled coil environment", "tags":[ + "d-cysteine", + "de novo design", "de novo three-stranded coiled coil", - "tris-thiolate zn(ii)s3cl complex", - "d-amino acids in protein design", "de novo protein", - "d-cysteine", - "de novo design" + "tris-thiolate zn(ii)s3cl complex", + "d-amino acids in protein design" ], "keywords":[ - "work", - "analysis", - "opens", - "documented", - "thus", - "use", - "metal", + "simply", + "opposite", + "enforce", + "number", + "show", + "well", + "single", + "side", "acid", - "crystallography", - "substantially", - "sterics", - "designed", + "within", + "promises", + "ligands", + "new", "cd", - "show", - "ii", - "order", - "altered", - "bind", + "controlling", + "positions", + "binding", + "coordination", + "site", + "confirmed", + "apo", "precise", - "structure", - "c", + "chains", + "indicates", "zn", - "infancy", - "however", - "modifies", - "spectroscopic", - "coiled", - "chirality", - "proteins", + "using", "l", - "coordination", - "h", + "occurring", + "sterics", + "documented", + "metal", + "however", + "metalloproteins", + "examine", + "metals", + "mixture", + "ligand", + "effect", + "thus", + "cl", "although", - "number", + "control", + "bind", + "proteins", "published", - "3", - "occurring", - "preorganized", - "controlling", - "alter", - "rotate", - "naturally", - "positions", + "use", + "2", "center", - "mixture", - "sphere", + "rotate", "future", - "suitable", - "native", - "coil", - "enforce", - "ligands", - "indicates", - "previously", + "c", + "spectroscopic", + "configuration", + "pocket", + "moreover", + "work", + "preferred", + "modifies", + "altered", + "species", + "environment", "properties", - "impact", - "control", - "powerful", + "fold", + "cysteine", + "tool", "amino", - "geometry", - "altering", - "acids", - "moreover", - "stereochemistry", - "configuration", "shown", - "examine", - "apo", + "stereochemistry", + "substantially", + "present", + "altering", + "designed", + "analysis", + "order", + "naturally", + "h", + "geometry", + "opens", "observed", - "comparison", - "metals", + "suitable", + "3", + "previously", + "sphere", + "structure", + "avenue", "csl16", - "using", - "present", - "effect", - "opposite", + "chirality", + "powerful", + "crystallography", + "impact", "ion", - "ligand", - "chains", - "cysteine", - "single", - "avenue", - "metalloproteins", - "fold", - "preferred", - "species", - "well", - "confirmed", - "promises", - "simply", - "binding", - "2", - "cl", - "environment", "understanding", - "within", - "side", - "pocket", - "site", + "infancy", + "coiled", + "native", + "alter", + "coil", + "acids", + "preorganized", "create", - "tool", - "new" + "comparison", + "ii" ], "release_date":"2017-04-26", "publication":"\"d-Cysteine Ligands Control Metal Geometries within De Novo Designed Three-Stranded Coiled Coils\", Chemistry, 23, 8232-8243", @@ -216626,11 +217176,11 @@ "seq_thr_sim_designed":[ { "sim":57.0, - "partner":"5u9u" + "partner":"5k92" }, { "sim":57.0, - "partner":"5k92" + "partner":"5u9u" }, { "sim":51.0, @@ -216642,27 +217192,27 @@ }, { "sim":51.0, - "partner":"5kb1" + "partner":"7n2y" }, { "sim":51.0, - "partner":"6egl" + "partner":"5kb1" }, { "sim":51.0, - "partner":"7n2y" + "partner":"5kb0" }, { "sim":51.0, - "partner":"5kb0" + "partner":"6egl" }, { "sim":51.0, - "partner":"6egm" + "partner":"7n2z" }, { "sim":51.0, - "partner":"7n2z" + "partner":"6egm" }, { "sim":51.0, @@ -216681,10 +217231,6 @@ "sim":0.9983999729, "partner":"5u9u" }, - { - "sim":0.961499989, - "partner":"3h5g" - }, { "sim":1.0, "partner":"2jgo" @@ -216698,20 +217244,32 @@ "partner":"3h5f" }, { - "sim":0.9908000231, - "partner":"1cos" + "sim":0.961499989, + "partner":"3h5g" }, { "sim":0.9943000078, "partner":"2x6p" }, + { + "sim":0.9908000231, + "partner":"1cos" + }, { "sim":0.9905999899, "partner":"5uxt" }, { - "sim":0.950699985, - "partner":"6ego" + "sim":0.9531999826, + "partner":"5kb0" + }, + { + "sim":0.9542000294, + "partner":"5kb2" + }, + { + "sim":0.9542000294, + "partner":"6egp" }, { "sim":0.99150002, @@ -216745,37 +217303,29 @@ "sim":0.9872999787, "partner":"6u47" }, - { - "sim":0.9894999862, - "partner":"6v58" - }, - { - "sim":0.9894999862, - "partner":"6v4y" - }, { "sim":0.9850999713, "partner":"6q25" }, { - "sim":0.9524999857, - "partner":"6v57" + "sim":0.9894999862, + "partner":"6v58" }, { - "sim":0.9527000189, - "partner":"6ovv" + "sim":0.9894999862, + "partner":"6v4y" }, { - "sim":0.9527000189, - "partner":"6ov9" + "sim":0.9542000294, + "partner":"6mcd" }, { "sim":0.9653999805, "partner":"1coi" }, { - "sim":0.9563999772, - "partner":"6q5r" + "sim":0.9524999857, + "partner":"6v57" }, { "sim":0.9527000189, @@ -216786,24 +217336,24 @@ "partner":"5vte" }, { - "sim":0.9531000257, - "partner":"6q5q" + "sim":0.950699985, + "partner":"6ego" }, { - "sim":0.9531999826, - "partner":"5kb0" + "sim":0.9527000189, + "partner":"6ovv" }, { - "sim":0.9542000294, - "partner":"5kb2" + "sim":0.9527000189, + "partner":"6ov9" }, { - "sim":0.9542000294, - "partner":"6egp" + "sim":0.9563999772, + "partner":"6q5r" }, { - "sim":0.9542000294, - "partner":"6mcd" + "sim":0.9531000257, + "partner":"6q5q" }, { "sim":0.9524999857, @@ -216827,7 +217377,7 @@ ], "seq_max_sim_designed":{ "sim":57.0, - "partner":"5u9u" + "partner":"5k92" }, "seq_max_sim_natural":[ @@ -216892,113 +217442,113 @@ "subtitle":"De novo three-stranded coiled coil peptide containing a tris-thiolate site engineered by d-cysteine ligands", "tags":[ "d-amino acids in protein design", - "d-cysteine", "de novo protein", + "d-cysteine", "de novo three-stranded coiled coil peptide" ], "keywords":[ - "work", - "analysis", - "opens", - "documented", - "thus", - "use", - "metal", + "simply", + "opposite", + "enforce", + "number", + "show", + "well", + "single", + "side", "acid", - "crystallography", - "substantially", - "sterics", - "designed", + "within", + "promises", + "ligands", + "new", "cd", - "show", - "ii", - "order", - "altered", - "bind", + "controlling", + "positions", + "binding", + "coordination", + "site", + "confirmed", + "apo", "precise", - "structure", - "c", + "chains", + "indicates", "zn", - "infancy", - "however", - "modifies", - "spectroscopic", - "coiled", - "chirality", - "proteins", + "using", "l", - "coordination", - "h", + "occurring", + "sterics", + "documented", + "metal", + "however", + "metalloproteins", + "examine", + "metals", + "mixture", + "ligand", + "effect", + "thus", + "cl", "although", - "number", + "control", + "bind", + "proteins", "published", - "3", - "occurring", - "preorganized", - "controlling", - "alter", - "rotate", - "naturally", - "positions", + "use", + "2", "center", - "mixture", - "sphere", + "rotate", "future", - "suitable", - "native", - "coil", - "enforce", - "ligands", - "indicates", - "previously", + "c", + "spectroscopic", + "configuration", + "pocket", + "moreover", + "work", + "preferred", + "modifies", + "altered", + "species", + "environment", "properties", - "impact", - "control", - "powerful", + "fold", + "cysteine", + "tool", "amino", - "geometry", - "altering", - "acids", - "moreover", - "stereochemistry", - "configuration", "shown", - "examine", - "apo", + "stereochemistry", + "substantially", + "present", + "altering", + "designed", + "analysis", + "order", + "naturally", + "h", + "geometry", + "opens", "observed", - "comparison", - "metals", + "suitable", + "3", + "previously", + "sphere", + "structure", + "avenue", "csl16", - "using", - "present", - "effect", - "opposite", + "chirality", + "powerful", + "crystallography", + "impact", "ion", - "ligand", - "chains", - "cysteine", - "single", - "avenue", - "metalloproteins", - "fold", - "preferred", - "species", - "well", - "confirmed", - "promises", - "simply", - "binding", - "2", - "cl", - "environment", "understanding", - "within", - "side", - "pocket", - "site", + "infancy", + "coiled", + "native", + "alter", + "coil", + "acids", + "preorganized", "create", - "tool", - "new" + "comparison", + "ii" ], "release_date":"2017-04-26", "publication":"\"d-Cysteine Ligands Control Metal Geometries within De Novo Designed Three-Stranded Coiled Coils\", Chemistry, 23, 8232-8243", @@ -217031,11 +217581,11 @@ "seq_thr_sim_designed":[ { "sim":57.0, - "partner":"5k92" + "partner":"5u9t" }, { "sim":57.0, - "partner":"5u9t" + "partner":"5k92" }, { "sim":51.0, @@ -217047,27 +217597,27 @@ }, { "sim":51.0, - "partner":"5kb1" + "partner":"7n2y" }, { "sim":51.0, - "partner":"6egl" + "partner":"5kb1" }, { "sim":51.0, - "partner":"7n2y" + "partner":"5kb0" }, { "sim":51.0, - "partner":"5kb0" + "partner":"6egl" }, { "sim":51.0, - "partner":"6egm" + "partner":"7n2z" }, { "sim":51.0, - "partner":"7n2z" + "partner":"6egm" }, { "sim":51.0, @@ -217091,13 +217641,21 @@ "partner":"3ljm" }, { - "sim":0.9886999726, - "partner":"1cos" + "sim":0.9599000216, + "partner":"3h5f" + }, + { + "sim":0.9582999945, + "partner":"3h5g" }, { "sim":0.9983999729, "partner":"2jgo" }, + { + "sim":0.9886999726, + "partner":"1cos" + }, { "sim":0.9970999956, "partner":"2x6p" @@ -217106,6 +217664,10 @@ "sim":0.9973999858, "partner":"5uxt" }, + { + "sim":0.9552000165, + "partner":"6ego" + }, { "sim":0.9986000061, "partner":"6osd" @@ -217114,21 +217676,17 @@ "sim":1.0, "partner":"6q1w" }, - { - "sim":0.9988999963, - "partner":"6v5g" - }, { "sim":1.0, - "partner":"6v5i" + "partner":"6u47" }, { "sim":1.0, "partner":"6v5j" }, { - "sim":1.0, - "partner":"6u47" + "sim":0.9986000061, + "partner":"6v4y" }, { "sim":0.9937999845, @@ -217138,17 +217696,21 @@ "sim":0.9973999858, "partner":"6ovs" }, + { + "sim":0.9962000251, + "partner":"6q25" + }, { "sim":0.9973999858, "partner":"6v58" }, { - "sim":0.9986000061, - "partner":"6v4y" + "sim":0.9988999963, + "partner":"6v5g" }, { - "sim":0.9962000251, - "partner":"6q25" + "sim":1.0, + "partner":"6v5i" }, { "sim":0.961499989, @@ -217158,10 +217720,6 @@ "sim":0.9585000277, "partner":"6os8" }, - { - "sim":0.9602000117, - "partner":"6ovv" - }, { "sim":0.9602000117, "partner":"6ovu" @@ -217170,6 +217728,10 @@ "sim":0.9600999951, "partner":"6q22" }, + { + "sim":0.9602000117, + "partner":"6ovv" + }, { "sim":0.9575999975, "partner":"6ov9" @@ -217190,18 +217752,6 @@ "sim":0.9865000248, "partner":"5vte" }, - { - "sim":0.9599000216, - "partner":"3h5f" - }, - { - "sim":0.9582999945, - "partner":"3h5g" - }, - { - "sim":0.9552000165, - "partner":"6ego" - }, { "sim":0.9559999704, "partner":"6q5q" @@ -217216,7 +217766,7 @@ ], "seq_max_sim_designed":{ "sim":57.0, - "partner":"5k92" + "partner":"5u9t" }, "seq_max_sim_natural":[ @@ -217301,127 +217851,127 @@ ], "subtitle":"Zinc-binding structure of a catalytic amyloid from solid-state nmr spectroscopy", "tags":[ - "amyloid", - "metal binding protein" + "metal binding protein", + "amyloid" ], "keywords":[ - "evolution", - "houses", - "bridge", - "pathologic", - "leaving", + "molecular", "delicate", - "metal", - "ions", - "catalyzes", - "misfolding", - "peptide", - "register", - "bases", - "geometries", - "determine", - "shapes", - "provide", - "throughout", - "parallel", - "arranged", - "position", - "interactions", + "hydrophobic", + "structural", + "key", + "precursor", + "side", + "free", + "amyloids", + "ligands", + "bridge", + "protein", "bioinformatics", - "represent", - "structure", - "unusual", + "infinite", + "product", + "binding", + "site", + "throughout", + "register", + "forms", + "catalytic", + "amphiphilic", + "two", + "attractive", + "chains", + "metalloamyloids", + "adjacent", "zn", - "turn", - "axis", + "needed", + "water", + "life", + "reactivity", + "catalyze", + "defines", + "metal", "backbones", - "metalloamyloid", - "histidines", - "interfaces", - "fibril", - "chain", + "reactions", + "ligand", + "residues", + "bilayers", + "polar", + "ester", + "frameworks", + "axis", "proteins", - "facilitating", - "amphiphilic", - "reactivity", + "size", "interplay", - "advanced", - "small", - "interface", - "materials", - "site", - "ability", - "assemble", - "sheets", - "alternating", - "structures", - "life", - "metalloamyloids", - "bilayers", + "ions", + "end", + "2", + "shapes", "hydrated", + "leaving", + "activation", + "interface", + "small", + "evolution", + "along", + "fibril", + "chemical", + "stabilize", + "peptide", + "bases", + "misfolding", + "geometries", + "chain", + "stacked", + "functional", "biology", - "size", - "ligands", + "represent", + "apolar", + "environment", + "good", + "third", + "also", + "alternating", + "sheets", + "ability", + "arranged", + "parallel", + "reveals", + "whereas", + "determine", + "materials", + "unusual", "form", - "free", + "catalyzes", "chelation", - "early", - "molecular", - "functional", - "hydrolysis", - "frameworks", - "reveals", - "chemical", + "interfaces", + "histidine", "geometry", - "catalytic", - "class", + "structures", "call", - "apolar", - "ester", - "reactions", - "stacked", - "stabilize", - "catalyze", - "defines", - "hydrophobic", - "nmr", - "stabilized", - "good", - "histidine", - "key", + "understand", "completes", - "structural", - "might", + "hydrolysis", + "houses", "align", - "ligand", - "chains", + "structure", + "might", + "provide", + "nmr", + "interactions", + "pathologic", + "class", + "histidines", "strands", - "also", - "attractive", - "product", - "along", - "understand", - "residues", - "needed", - "adjacent", - "two", - "infinite", - "amyloids", - "combine", - "polar", "amyloid", - "protein", - "2", - "end", - "third", - "water", - "environment", - "precursor", - "side", - "activation", - "binding", - "forms", - "whereas" + "early", + "turn", + "combine", + "facilitating", + "position", + "assemble", + "metalloamyloid", + "stabilized", + "advanced" ], "release_date":"2017-05-31", "publication":"\"Zinc-binding structure of a catalytic amyloid from solid-state NMR\", Proc. Natl. Acad. Sci. U.S.A., 114, 6191-6196", @@ -217552,105 +218102,105 @@ ], "subtitle":"Solution structure of the de novo mini protein hhh_rd1_0142", "tags":[ - "all-alpha", - "mini protein", + "de novo design", "de novo protein", "helix-helix-helix", - "de novo design" + "mini protein", + "all-alpha" ], "keywords":[ - "analysis", + "unsuccessful", + "rate", + "optimized", + "number", + "overcome", + "collectively", + "computation", + "1000", + "folding", + "protein", + "increased", + "topologies", + "became", + "decoding", + "produced", + "novo", + "weak", + "stable", + "initially", + "encoded", + "goal", + "cycle", "us", + "examine", "gene", - "initially", - "contributions", - "systematically", - "combined", - "measure", - "decoding", - "designed", + "identified", + "although", "uncharted", - "basic", + "control", + "stability", + "combined", + "approach", + "proteins", + "mutants", + "experiment", + "success", + "found", + "four", + "tight", + "entropic", + "computational", + "susceptibility", + "iteration", + "science", "protease", - "achieves", + "challenging", + "design", + "miniproteins", + "transform", + "subtle", + "thousands", + "natural", "potential", - "increasingly", - "sequences", - "overcome", - "interactions", + "synthesis", + "fold", + "point", + "complexity", + "measure", "forces", - "1000", - "determines", - "proteins", + "sequence", "unique", - "thousands", + "evolved", + "contributions", + "designed", + "analysis", "assay", - "de", - "although", - "point", + "basic", + "sequences", + "unlike", + "revealed", + "space", "6", - "goal", - "number", - "nature", - "feedback", - "experiment", "structures", - "natural", - "complexity", - "transform", + "de", + "feedback", + "interactions", + "nature", "function", - "native", - "revealed", - "47", - "evolved", - "mutants", - "cost", - "cycle", - "stability", - "control", - "four", - "topologies", - "increased", - "challenging", - "became", - "entropic", - "synthesis", - "examine", - "rate", - "design", - "produced", - "weak", - "negative", - "stabilized", - "sequence", - "encoded", "known", - "susceptibility", - "unsuccessful", - "designs", - "subtle", - "optimized", - "approach", - "novo", - "stable", - "iteration", - "success", - "tight", "2500", - "computation", - "fold", - "sufficient", "enable", - "science", - "found", - "identified", - "protein", - "space", - "collectively", - "computational", - "unlike", - "folding", - "miniproteins" + "cost", + "native", + "negative", + "determines", + "47", + "sufficient", + "increasingly", + "designs", + "achieves", + "stabilized", + "systematically" ], "release_date":"2017-07-26", "publication":"\"Global analysis of protein folding using massively parallel design, synthesis, and testing\", Science, 357, 168-175", @@ -217781,103 +218331,103 @@ ], "subtitle":"Solution structure of the de novo mini protein eehee_rd3_1049", "tags":[ - "mini protein", "de novo protein", - "de novo design" + "de novo design", + "mini protein" ], "keywords":[ - "analysis", + "unsuccessful", + "rate", + "optimized", + "number", + "overcome", + "collectively", + "computation", + "1000", + "folding", + "protein", + "increased", + "topologies", + "became", + "decoding", + "produced", + "novo", + "weak", + "stable", + "initially", + "encoded", + "goal", + "cycle", "us", + "examine", "gene", - "initially", - "contributions", - "systematically", - "combined", - "measure", - "decoding", - "designed", + "identified", + "although", "uncharted", - "basic", + "control", + "stability", + "combined", + "approach", + "proteins", + "mutants", + "experiment", + "success", + "found", + "four", + "tight", + "entropic", + "computational", + "susceptibility", + "iteration", + "science", "protease", - "achieves", + "challenging", + "design", + "miniproteins", + "transform", + "subtle", + "thousands", + "natural", "potential", - "increasingly", - "sequences", - "overcome", - "interactions", + "synthesis", + "fold", + "point", + "complexity", + "measure", "forces", - "1000", - "determines", - "proteins", + "sequence", "unique", - "thousands", + "evolved", + "contributions", + "designed", + "analysis", "assay", - "de", - "although", - "point", + "basic", + "sequences", + "unlike", + "revealed", + "space", "6", - "goal", - "number", - "nature", - "feedback", - "experiment", "structures", - "natural", - "complexity", - "transform", + "de", + "feedback", + "interactions", + "nature", "function", - "native", - "revealed", - "47", - "evolved", - "mutants", - "cost", - "cycle", - "stability", - "control", - "four", - "topologies", - "increased", - "challenging", - "became", - "entropic", - "synthesis", - "examine", - "rate", - "design", - "produced", - "weak", - "negative", - "stabilized", - "sequence", - "encoded", "known", - "susceptibility", - "unsuccessful", - "designs", - "subtle", - "optimized", - "approach", - "novo", - "stable", - "iteration", - "success", - "tight", "2500", - "computation", - "fold", - "sufficient", "enable", - "science", - "found", - "identified", - "protein", - "space", - "collectively", - "computational", - "unlike", - "folding", - "miniproteins" + "cost", + "native", + "negative", + "determines", + "47", + "sufficient", + "increasingly", + "designs", + "achieves", + "stabilized", + "systematically" ], "release_date":"2017-07-26", "publication":"\"Global analysis of protein folding using massively parallel design, synthesis, and testing\", Science, 357, 168-175", @@ -218008,103 +218558,103 @@ ], "subtitle":"Solution structure of the de novo mini protein ehee_rd1_0284", "tags":[ - "mini protein", "de novo protein", - "de novo design" + "de novo design", + "mini protein" ], "keywords":[ - "analysis", + "unsuccessful", + "rate", + "optimized", + "number", + "overcome", + "collectively", + "computation", + "1000", + "folding", + "protein", + "increased", + "topologies", + "became", + "decoding", + "produced", + "novo", + "weak", + "stable", + "initially", + "encoded", + "goal", + "cycle", "us", + "examine", "gene", - "initially", - "contributions", - "systematically", - "combined", - "measure", - "decoding", - "designed", + "identified", + "although", "uncharted", - "basic", + "control", + "stability", + "combined", + "approach", + "proteins", + "mutants", + "experiment", + "success", + "found", + "four", + "tight", + "entropic", + "computational", + "susceptibility", + "iteration", + "science", "protease", - "achieves", + "challenging", + "design", + "miniproteins", + "transform", + "subtle", + "thousands", + "natural", "potential", - "increasingly", - "sequences", - "overcome", - "interactions", + "synthesis", + "fold", + "point", + "complexity", + "measure", "forces", - "1000", - "determines", - "proteins", + "sequence", "unique", - "thousands", + "evolved", + "contributions", + "designed", + "analysis", "assay", - "de", - "although", - "point", + "basic", + "sequences", + "unlike", + "revealed", + "space", "6", - "goal", - "number", - "nature", - "feedback", - "experiment", "structures", - "natural", - "complexity", - "transform", + "de", + "feedback", + "interactions", + "nature", "function", - "native", - "revealed", - "47", - "evolved", - "mutants", - "cost", - "cycle", - "stability", - "control", - "four", - "topologies", - "increased", - "challenging", - "became", - "entropic", - "synthesis", - "examine", - "rate", - "design", - "produced", - "weak", - "negative", - "stabilized", - "sequence", - "encoded", "known", - "susceptibility", - "unsuccessful", - "designs", - "subtle", - "optimized", - "approach", - "novo", - "stable", - "iteration", - "success", - "tight", "2500", - "computation", - "fold", - "sufficient", "enable", - "science", - "found", - "identified", - "protein", - "space", - "collectively", - "computational", - "unlike", - "folding", - "miniproteins" + "cost", + "native", + "negative", + "determines", + "47", + "sufficient", + "increasingly", + "designs", + "achieves", + "stabilized", + "systematically" ], "release_date":"2017-07-26", "publication":"\"Global analysis of protein folding using massively parallel design, synthesis, and testing\", Science, 357, 168-175", @@ -218206,89 +218756,89 @@ ], "subtitle":"Coiled-coil trimer with glu:trp:lys triad", "tags":[ + "triad", "de novo protein", - "coiled coil", - "triad" + "coiled coil" ], "keywords":[ - "evidence", - "bridge", - "possibly", - "stabilizing", - "suggest", - "close", - "ions", - "acid", - "peptide", - "substantially", - "enhance", - "cd", - "variable", - "drop", - "ionic", - "position", - "8", - "favorable", - "however", - "cyclic", - "aromatic", - "interaction", - "longer", - "anion", - "enables", + "especially", "negatively", - "positively", + "homotrimer", + "trp", "presence", - "leu", - "hydrocarbon", - "portion", - "acyclic", + "acid", + "residue", + "bridge", + "occupies", + "cd", + "protein", + "salt", + "lines", + "arenes", + "close", "charged", "circular", - "arenes", - "contribute", - "stability", - "salt", - "glu", - "amino", - "substantial", - "temperature", + "cation", + "two", + "possibility", + "persist", + "water", + "enables", "tends", - "several", + "possibly", + "conformational", + "however", "donor", - "positioned", - "context", + "enhance", + "positively", + "stabilizing", + "acyclic", "effect", - "persist", - "surface", - "proximity", - "indicate", - "cation", - "could", - "occupies", + "relative", + "positioned", + "cyclic", + "hydrocarbon", + "stability", + "evidence", + "ions", + "several", + "suggest", + "longer", + "leu", + "substantial", + "peptide", "precipitously", - "trp", + "variable", + "surface", "relies", - "excluding", "lys", - "groups", - "conformational", - "also", - "homotrimer", - "possibility", + "context", + "drop", + "proximity", "experiments", - "especially", - "two", + "also", + "groups", "explore", - "protein", - "residue", - "distances", + "amino", + "glu", + "interaction", + "ionic", + "substantially", + "arene", + "could", + "excluding", + "aromatic", "space", - "water", + "indicate", + "portion", + "distances", + "contribute", + "temperature", + "anion", "dichroism", - "relative", - "arene", - "lines" + "favorable", + "position", + "8" ], "release_date":"2017-08-09", "publication":"\"Enhancing a long-range salt bridge with intermediate aromatic and nonpolar amino acids\", Org. Biomol. Chem., 15, 5882-5886", @@ -218326,52 +218876,40 @@ ], "struct_thr_sim_designed":[ { - "sim":0.9986000061, - "partner":"6v50" - }, - { - "sim":0.9973000288, - "partner":"6ovs" + "sim":0.9653000236, + "partner":"6ov9" }, { - "sim":0.9986000061, - "partner":"6q25" + "sim":1.0, + "partner":"6osd" }, { "sim":0.9986000061, - "partner":"6v58" - }, - { - "sim":0.9611999989, - "partner":"6os8" - }, - { - "sim":0.9611999989, - "partner":"6ovu" + "partner":"6v50" }, { "sim":1.0, - "partner":"6osd" + "partner":"6q1w" }, { "sim":1.0, "partner":"6u47" }, { - "sim":1.0, - "partner":"6q1w" - }, - { - "sim":0.9625999928, - "partner":"6q22" + "sim":0.9986000061, + "partner":"6v58" }, { "sim":0.9907000065, "partner":"6v4y" }, { - "sim":0.9653000236, - "partner":"6v57" + "sim":0.9973000288, + "partner":"6ovs" + }, + { + "sim":0.9986000061, + "partner":"6q25" }, { "sim":1.0, @@ -218383,16 +218921,28 @@ }, { "sim":0.9653000236, - "partner":"6ov9" + "partner":"6v57" }, { - "sim":1.0, - "partner":"6v5i" + "sim":0.9611999989, + "partner":"6os8" + }, + { + "sim":0.9611999989, + "partner":"6ovu" }, { "sim":0.9552000165, "partner":"6ovv" }, + { + "sim":0.9625999928, + "partner":"6q22" + }, + { + "sim":1.0, + "partner":"6v5i" + }, { "sim":0.9940000176, "partner":"2jgo" @@ -218563,104 +219113,104 @@ ], "subtitle":"Solution nmr structure of the de novo mini protein heeh_rd4_0097", "tags":[ - "mini protein", "de novo protein", "de novo design", + "mini protein", "helix-strand-strand-helix" ], "keywords":[ - "analysis", + "unsuccessful", + "rate", + "optimized", + "number", + "overcome", + "collectively", + "computation", + "1000", + "folding", + "protein", + "increased", + "topologies", + "became", + "decoding", + "produced", + "novo", + "weak", + "stable", + "initially", + "encoded", + "goal", + "cycle", "us", + "examine", "gene", - "initially", - "contributions", - "systematically", - "combined", - "measure", - "decoding", - "designed", + "identified", + "although", "uncharted", - "basic", + "control", + "stability", + "combined", + "approach", + "proteins", + "mutants", + "experiment", + "success", + "found", + "four", + "tight", + "entropic", + "computational", + "susceptibility", + "iteration", + "science", "protease", - "achieves", + "challenging", + "design", + "miniproteins", + "transform", + "subtle", + "thousands", + "natural", "potential", - "increasingly", - "sequences", - "overcome", - "interactions", + "synthesis", + "fold", + "point", + "complexity", + "measure", "forces", - "1000", - "determines", - "proteins", + "sequence", "unique", - "thousands", + "evolved", + "contributions", + "designed", + "analysis", "assay", - "de", - "although", - "point", + "basic", + "sequences", + "unlike", + "revealed", + "space", "6", - "goal", - "number", - "nature", - "feedback", - "experiment", "structures", - "natural", - "complexity", - "transform", + "de", + "feedback", + "interactions", + "nature", "function", - "native", - "revealed", - "47", - "evolved", - "mutants", - "cost", - "cycle", - "stability", - "control", - "four", - "topologies", - "increased", - "challenging", - "became", - "entropic", - "synthesis", - "examine", - "rate", - "design", - "produced", - "weak", - "negative", - "stabilized", - "sequence", - "encoded", "known", - "susceptibility", - "unsuccessful", - "designs", - "subtle", - "optimized", - "approach", - "novo", - "stable", - "iteration", - "success", - "tight", "2500", - "computation", - "fold", - "sufficient", "enable", - "science", - "found", - "identified", - "protein", - "space", - "collectively", - "computational", - "unlike", - "folding", - "miniproteins" + "cost", + "native", + "negative", + "determines", + "47", + "sufficient", + "increasingly", + "designs", + "achieves", + "stabilized", + "systematically" ], "release_date":"2017-07-26", "publication":"\"Global analysis of protein folding using massively parallel design, synthesis, and testing\", Science, 357, 168-175", @@ -218786,96 +219336,96 @@ ], "subtitle":"De novo design of novel covalent constrained meso-size peptide scaffolds with unique tertiary structures", "tags":[ + "covalent constrained peptide", "de novo protein", - "de novo design", - "covalent constrained peptide" + "de novo design" ], "keywords":[ - "part", - "use", - "developing", - "metal", - "selection", - "crystallography", - "including", - "designed", - "provide", - "determined", - "versatile", - "interactions", - "structure", - "inhibitors", - "general", - "restraints", - "prepared", - "proteins", - "mesosized", - "unique", - "de", - "biosynthetic", - "typically", - "successfully", - "small", - "easily", - "nature", - "structures", "templates", - "predictable", - "natural", - "solution", - "tertiary", - "macrocyclic", - "alternatively", + "defined", "ease", + "hydrophobic", + "around", + "core", + "macrocyclic", + "biosynthetic", + "developing", + "folding", + "bicyclic", + "protein", + "successfully", + "binding", + "general", + "novo", "motifs", + "agent", "either", - "form", - "covcore", + "tertiary", + "typically", + "terms", + "metal", + "ones", + "predictable", + "prepared", + "accessible", + "disulfide", + "approach", + "proteins", "large", + "packing", + "part", + "use", "multivalent", - "defined", + "small", + "found", + "conventional", + "bond", "chemical", - "bicyclic", - "apolar", - "method", - "synthesis", "stabilize", + "computational", + "including", + "relies", + "covcore", "design", - "core", - "agent", - "bond", - "hydrophobic", - "nmr", + "mesosized", + "selection", + "natural", + "apolar", "precursors", + "rosetta", + "fold", + "synthesis", + "also", + "easily", "lying", - "indicate", + "solution", "formation", - "disulfide", - "around", - "packing", - "conventional", - "integral", - "ones", - "3d", - "relies", - "accessible", - "approach", - "also", - "novo", + "incorporating", "contrast", - "rosetta", - "fold", + "versatile", "peptides", - "found", - "terms", - "folds", - "incorporating", - "protein", - "computational", - "folding", - "binding", "developed", - "libraries" + "3d", + "unique", + "method", + "folds", + "designed", + "form", + "indicate", + "structures", + "de", + "integral", + "structure", + "provide", + "determined", + "crystallography", + "nmr", + "interactions", + "nature", + "inhibitors", + "alternatively", + "libraries", + "restraints" ], "release_date":"2017-09-27", "publication":"\"De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures\", Proc. Natl. Acad. Sci. U.S.A., 114, 10852-10857", @@ -219002,97 +219552,97 @@ ], "subtitle":"De novo design of novel covalent constrained meso-size peptide scaffolds with unique tertiary structures", "tags":[ - "covalent core", "de novo protein", "constrained mess-size peptide", - "de novo design" + "de novo design", + "covalent core" ], "keywords":[ - "part", - "use", - "developing", - "metal", - "selection", - "crystallography", - "including", - "designed", - "provide", - "determined", - "versatile", - "interactions", - "structure", - "inhibitors", - "general", - "restraints", - "prepared", - "proteins", - "mesosized", - "unique", - "de", - "biosynthetic", - "typically", - "successfully", - "small", - "easily", - "nature", - "structures", "templates", - "predictable", - "natural", - "solution", - "tertiary", - "macrocyclic", - "alternatively", + "defined", "ease", + "hydrophobic", + "around", + "core", + "macrocyclic", + "biosynthetic", + "developing", + "folding", + "bicyclic", + "protein", + "successfully", + "binding", + "general", + "novo", "motifs", + "agent", "either", - "form", - "covcore", + "tertiary", + "typically", + "terms", + "metal", + "ones", + "predictable", + "prepared", + "accessible", + "disulfide", + "approach", + "proteins", "large", + "packing", + "part", + "use", "multivalent", - "defined", + "small", + "found", + "conventional", + "bond", "chemical", - "bicyclic", - "apolar", - "method", - "synthesis", "stabilize", + "computational", + "including", + "relies", + "covcore", "design", - "core", - "agent", - "bond", - "hydrophobic", - "nmr", + "mesosized", + "selection", + "natural", + "apolar", "precursors", + "rosetta", + "fold", + "synthesis", + "also", + "easily", "lying", - "indicate", + "solution", "formation", - "disulfide", - "around", - "packing", - "conventional", - "integral", - "ones", - "3d", - "relies", - "accessible", - "approach", - "also", - "novo", + "incorporating", "contrast", - "rosetta", - "fold", + "versatile", "peptides", - "found", - "terms", - "folds", - "incorporating", - "protein", - "computational", - "folding", - "binding", "developed", - "libraries" + "3d", + "unique", + "method", + "folds", + "designed", + "form", + "indicate", + "structures", + "de", + "integral", + "structure", + "provide", + "determined", + "crystallography", + "nmr", + "interactions", + "nature", + "inhibitors", + "alternatively", + "libraries", + "restraints" ], "release_date":"2017-10-04", "publication":"\"De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures\", Proc. Natl. Acad. Sci. U.S.A., 114, 10852-10857", @@ -219197,43 +219747,43 @@ "beta-hairpin" ], "keywords":[ - "composed", - "shifting", - "oligomers", - "associated", "a\u03b2", - "investigated", - "dodecamer", - "neurodegeneration", - "crystallography", - "peptide", - "fused", - "trimers", - "may", - "thought", - "triangular", + "form", + "disease", "pairings", - "alzheimer", - "help", + "juxtaposed", "constrained", - "explain", - "dodecamers", + "investigated", + "formed", + "help", "structures", "soluble", + "dodecamer", + "oligomers", + "macrocyclic", + "alzheimer", + "effect", + "three", + "assembly", + "explain", + "fused", + "trimers", "residue", - "using", + "crystallography", "explored", + "shifting", "pairing", - "effect", - "assembly", - "three", - "macrocyclic", - "juxtaposed", - "form", - "disease", - "formed", + "neurodegeneration", + "may", + "dodecamers", + "thought", "forms", - "compact" + "composed", + "triangular", + "compact", + "associated", + "using", + "peptide" ], "release_date":"2017-06-28", "publication":"\"X-ray Crystallographic Structure of a Compact Dodecamer from a Peptide Derived from A beta 16-36\", Org. Lett., 19, 3462-3465", @@ -219338,43 +219888,43 @@ "beta-hairpin" ], "keywords":[ - "composed", - "shifting", - "oligomers", - "associated", "a\u03b2", - "investigated", - "dodecamer", - "neurodegeneration", - "crystallography", - "peptide", - "fused", - "trimers", - "may", - "thought", - "triangular", + "form", + "disease", "pairings", - "alzheimer", - "help", + "juxtaposed", "constrained", - "explain", - "dodecamers", + "investigated", + "formed", + "help", "structures", "soluble", + "dodecamer", + "oligomers", + "macrocyclic", + "alzheimer", + "effect", + "three", + "assembly", + "explain", + "fused", + "trimers", "residue", - "using", + "crystallography", "explored", + "shifting", "pairing", - "effect", - "assembly", - "three", - "macrocyclic", - "juxtaposed", - "form", - "disease", - "formed", + "neurodegeneration", + "may", + "dodecamers", + "thought", "forms", - "compact" + "composed", + "triangular", + "compact", + "associated", + "using", + "peptide" ], "release_date":"2017-06-28", "publication":"\"X-ray Crystallographic Structure of a Compact Dodecamer from a Peptide Derived from A beta 16-36\", Org. Lett., 19, 3462-3465", @@ -219478,43 +220028,43 @@ "beta-hairpin" ], "keywords":[ - "composed", - "shifting", - "oligomers", - "associated", "a\u03b2", - "investigated", - "dodecamer", - "neurodegeneration", - "crystallography", - "peptide", - "fused", - "trimers", - "may", - "thought", - "triangular", + "form", + "disease", "pairings", - "alzheimer", - "help", + "juxtaposed", "constrained", - "explain", - "dodecamers", + "investigated", + "formed", + "help", "structures", "soluble", + "dodecamer", + "oligomers", + "macrocyclic", + "alzheimer", + "effect", + "three", + "assembly", + "explain", + "fused", + "trimers", "residue", - "using", + "crystallography", "explored", + "shifting", "pairing", - "effect", - "assembly", - "three", - "macrocyclic", - "juxtaposed", - "form", - "disease", - "formed", + "neurodegeneration", + "may", + "dodecamers", + "thought", "forms", - "compact" + "composed", + "triangular", + "compact", + "associated", + "using", + "peptide" ], "release_date":"2017-06-28", "publication":"\"X-ray Crystallographic Structure of a Compact Dodecamer from a Peptide Derived from A beta 16-36\", Org. Lett., 19, 3462-3465", @@ -219600,12 +220150,12 @@ ], "subtitle":"Crystal structure of a highly specific and potent usp7 ubiquitin variant inhibitor", "tags":[ - "inhibitor", - "structural genomics", - "ubiquitin", - "de novo protein", + "sgc", "structural genomics consortium", - "sgc" + "de novo protein", + "ubiquitin", + "inhibitor", + "structural genomics" ], "keywords":[ "description", @@ -219647,10 +220197,6 @@ "sim":138.0, "partner":"3k9o" }, - { - "sim":138.0, - "partner":"2w9n" - }, { "sim":138.0, "partner":"3znz" @@ -219663,6 +220209,10 @@ "sim":138.0, "partner":"3b0a" }, + { + "sim":138.0, + "partner":"2w9n" + }, { "sim":138.0, "partner":"2zvn" @@ -219701,11 +220251,11 @@ }, { "sim":137.0, - "partner":"4nqk" + "partner":"4p4h" }, { "sim":137.0, - "partner":"4p4h" + "partner":"4nqk" }, { "sim":137.0, @@ -219743,10 +220293,6 @@ "sim":136.0, "partner":"2y5b" }, - { - "sim":135.0, - "partner":"5jby" - }, { "sim":135.0, "partner":"5jbv" @@ -219761,12 +220307,16 @@ }, { "sim":135.0, - "partner":"3rul" + "partner":"5jby" }, { "sim":135.0, "partner":"3vfk" }, + { + "sim":135.0, + "partner":"3rul" + }, { "sim":135.0, "partner":"3dvn" @@ -219819,14 +220369,6 @@ "sim":135.0, "partner":"2ojr" }, - { - "sim":134.0, - "partner":"8rqi" - }, - { - "sim":134.0, - "partner":"3pt2" - }, { "sim":134.0, "partner":"1xd3" @@ -219891,6 +220433,10 @@ "sim":134.0, "partner":"4rf1" }, + { + "sim":134.0, + "partner":"8rqi" + }, { "sim":134.0, "partner":"3phw" @@ -219909,51 +220455,51 @@ }, { "sim":134.0, - "partner":"1p3q" + "partner":"3pt2" }, { "sim":134.0, - "partner":"1ubi" + "partner":"1s1q" }, { "sim":134.0, - "partner":"1v80" + "partner":"2dx5" }, { "sim":134.0, - "partner":"1wr6" + "partner":"2g45" }, { "sim":134.0, - "partner":"2hd5" + "partner":"2o6v" }, { "sim":134.0, - "partner":"2n3w" + "partner":"3alb" }, { "sim":134.0, - "partner":"3aul" + "partner":"3h7p" }, { "sim":134.0, - "partner":"3vht" + "partner":"3hm3" }, { "sim":134.0, - "partner":"3vuw" + "partner":"3ofi" }, { "sim":134.0, - "partner":"4boz" + "partner":"3tbl" }, { "sim":134.0, - "partner":"4s1z" + "partner":"4dhj" }, { "sim":134.0, - "partner":"4wzp" + "partner":"4s1z" }, { "sim":134.0, @@ -219961,132 +220507,40 @@ }, { "sim":134.0, - "partner":"5d0k" + "partner":"5d0m" }, { "sim":134.0, - "partner":"5gog" + "partner":"5lrw" }, { "sim":134.0, - "partner":"5jtv" + "partner":"5v1z" }, { "sim":134.0, - "partner":"5lrv" + "partner":"2jzz" }, { "sim":134.0, - "partner":"5ulh" + "partner":"2k6d" }, { "sim":134.0, - "partner":"1v81" + "partner":"3vux" }, { "sim":134.0, - "partner":"2o6v" + "partner":"4ddg" }, { "sim":134.0, - "partner":"3ugb" - }, - { - "sim":134.0, - "partner":"4dhj" - }, - { - "sim":134.0, - "partner":"5k9p" - }, - { - "sim":134.0, - "partner":"5mn9" - }, - { - "sim":134.0, - "partner":"1s1q" - }, - { - "sim":134.0, - "partner":"2kn5" - }, - { - "sim":134.0, - "partner":"3hm3" - }, - { - "sim":134.0, - "partner":"5goh" - }, - { - "sim":134.0, - "partner":"5n2w" - }, - { - "sim":134.0, - "partner":"5v1z" - }, - { - "sim":134.0, - "partner":"2dx5" - }, - { - "sim":134.0, - "partner":"2g45" - }, - { - "sim":134.0, - "partner":"3alb" - }, - { - "sim":134.0, - "partner":"3h7p" - }, - { - "sim":134.0, - "partner":"3ofi" - }, - { - "sim":134.0, - "partner":"3tbl" - }, - { - "sim":134.0, - "partner":"5d0m" - }, - { - "sim":134.0, - "partner":"5lrw" - }, - { - "sim":134.0, - "partner":"2jzz" - }, - { - "sim":134.0, - "partner":"2k6d" - }, - { - "sim":134.0, - "partner":"3vux" - }, - { - "sim":134.0, - "partner":"4ddg" - }, - { - "sim":134.0, - "partner":"4nql" + "partner":"4nql" }, { "sim":134.0, "partner":"5goi" }, - { - "sim":134.0, - "partner":"1f9j" - }, { "sim":134.0, "partner":"2den" @@ -220107,10 +220561,6 @@ "sim":134.0, "partner":"5nmc" }, - { - "sim":134.0, - "partner":"1g6j" - }, { "sim":134.0, "partner":"1xqq" @@ -220159,6 +220609,10 @@ "sim":134.0, "partner":"5lrx" }, + { + "sim":134.0, + "partner":"1f9j" + }, { "sim":134.0, "partner":"2mor" @@ -220179,6 +220633,10 @@ "sim":134.0, "partner":"5ulk" }, + { + "sim":134.0, + "partner":"1g6j" + }, { "sim":134.0, "partner":"1yd8" @@ -220255,6 +220713,10 @@ "sim":134.0, "partner":"5vey" }, + { + "sim":134.0, + "partner":"8k6v" + }, { "sim":134.0, "partner":"2d3g" @@ -220287,10 +220749,6 @@ "sim":134.0, "partner":"5go8" }, - { - "sim":134.0, - "partner":"1d3z" - }, { "sim":134.0, "partner":"2kox" @@ -220359,6 +220817,10 @@ "sim":134.0, "partner":"3wxg" }, + { + "sim":134.0, + "partner":"1d3z" + }, { "sim":134.0, "partner":"2ayo" @@ -220379,10 +220841,6 @@ "sim":134.0, "partner":"4m0w" }, - { - "sim":134.0, - "partner":"1cmx" - }, { "sim":134.0, "partner":"1nbf" @@ -220431,6 +220889,10 @@ "sim":134.0, "partner":"5n38" }, + { + "sim":134.0, + "partner":"8k6r" + }, { "sim":134.0, "partner":"1tbe" @@ -220455,6 +220917,10 @@ "sim":134.0, "partner":"5bnb" }, + { + "sim":134.0, + "partner":"1cmx" + }, { "sim":134.0, "partner":"1uzx" @@ -220507,6 +220973,10 @@ "sim":134.0, "partner":"5xbo" }, + { + "sim":134.0, + "partner":"8k6f" + }, { "sim":134.0, "partner":"2jri" @@ -220603,10 +221073,6 @@ "sim":134.0, "partner":"5x3n" }, - { - "sim":134.0, - "partner":"1aar" - }, { "sim":134.0, "partner":"1ogw" @@ -220653,15 +221119,15 @@ }, { "sim":134.0, - "partner":"5god" + "partner":"4wzp" }, { "sim":134.0, - "partner":"5jqs" + "partner":"5god" }, { "sim":134.0, - "partner":"1fxt" + "partner":"5jqs" }, { "sim":134.0, @@ -220687,6 +221153,10 @@ "sim":134.0, "partner":"5ulf" }, + { + "sim":134.0, + "partner":"1aar" + }, { "sim":134.0, "partner":"4s22" @@ -220707,6 +221177,18 @@ "sim":134.0, "partner":"2n3v" }, + { + "sim":134.0, + "partner":"5d0k" + }, + { + "sim":134.0, + "partner":"1fxt" + }, + { + "sim":134.0, + "partner":"1wr6" + }, { "sim":134.0, "partner":"2jf5" @@ -220723,6 +221205,10 @@ "sim":134.0, "partner":"3prm" }, + { + "sim":134.0, + "partner":"3vuw" + }, { "sim":134.0, "partner":"4ium" @@ -220731,18 +221217,94 @@ "sim":134.0, "partner":"5a5b" }, + { + "sim":134.0, + "partner":"1p3q" + }, { "sim":134.0, "partner":"1q5w" }, + { + "sim":134.0, + "partner":"4boz" + }, { "sim":134.0, "partner":"4uel" }, + { + "sim":134.0, + "partner":"5jtv" + }, { "sim":134.0, "partner":"5xdp" }, + { + "sim":134.0, + "partner":"1ubi" + }, + { + "sim":134.0, + "partner":"1v80" + }, + { + "sim":134.0, + "partner":"2hd5" + }, + { + "sim":134.0, + "partner":"2n3w" + }, + { + "sim":134.0, + "partner":"3aul" + }, + { + "sim":134.0, + "partner":"3vht" + }, + { + "sim":134.0, + "partner":"5gog" + }, + { + "sim":134.0, + "partner":"5lrv" + }, + { + "sim":134.0, + "partner":"5ulh" + }, + { + "sim":134.0, + "partner":"1v81" + }, + { + "sim":134.0, + "partner":"3ugb" + }, + { + "sim":134.0, + "partner":"5k9p" + }, + { + "sim":134.0, + "partner":"5mn9" + }, + { + "sim":134.0, + "partner":"2kn5" + }, + { + "sim":134.0, + "partner":"5goh" + }, + { + "sim":134.0, + "partner":"5n2w" + }, { "sim":134.0, "partner":"2mbb" @@ -220753,15 +221315,15 @@ }, { "sim":134.0, - "partner":"4r62" + "partner":"8k6i" }, { "sim":134.0, - "partner":"2mur" + "partner":"4r62" }, { "sim":134.0, - "partner":"3oj3" + "partner":"2mur" }, { "sim":134.0, @@ -220785,15 +221347,11 @@ }, { "sim":134.0, - "partner":"5m93" - }, - { - "sim":134.0, - "partner":"3jvz" + "partner":"3oj3" }, { "sim":134.0, - "partner":"4auq" + "partner":"5m93" }, { "sim":134.0, @@ -220801,7 +221359,7 @@ }, { "sim":134.0, - "partner":"8jrt" + "partner":"8k0g" }, { "sim":134.0, @@ -220827,6 +221385,18 @@ "sim":134.0, "partner":"5mnj" }, + { + "sim":134.0, + "partner":"8jrt" + }, + { + "sim":134.0, + "partner":"3jvz" + }, + { + "sim":134.0, + "partner":"4auq" + }, { "sim":134.0, "partner":"4whv" @@ -220873,15 +221443,15 @@ }, { "sim":134.0, - "partner":"5lks" + "partner":"8qyx" }, { "sim":134.0, - "partner":"4ujd" + "partner":"5lks" }, { "sim":134.0, - "partner":"8qyx" + "partner":"4ujd" }, { "sim":134.0, @@ -220917,11 +221487,7 @@ }, { "sim":133.0, - "partner":"2nbd" - }, - { - "sim":133.0, - "partner":"4jio" + "partner":"2nbe" }, { "sim":133.0, @@ -220931,10 +221497,6 @@ "sim":133.0, "partner":"5dk8" }, - { - "sim":133.0, - "partner":"2nbe" - }, { "sim":133.0, "partner":"5emz" @@ -220973,7 +221535,11 @@ }, { "sim":133.0, - "partner":"5umd" + "partner":"2nbd" + }, + { + "sim":133.0, + "partner":"4jio" }, { "sim":133.0, @@ -220981,7 +221547,7 @@ }, { "sim":133.0, - "partner":"4kzx" + "partner":"5umd" }, { "sim":133.0, @@ -221039,6 +221605,10 @@ "sim":133.0, "partner":"5lzv" }, + { + "sim":133.0, + "partner":"4kzx" + }, { "sim":133.0, "partner":"3q3f" @@ -221085,11 +221655,11 @@ }, { "sim":131.0, - "partner":"5t2a" + "partner":"8qie" }, { "sim":131.0, - "partner":"8qie" + "partner":"5t2a" }, { "sim":131.0, @@ -221167,29 +221737,25 @@ "sim":129.0, "partner":"1otr" }, - { - "sim":129.0, - "partner":"3olm" - }, { "sim":129.0, "partner":"4nnj" }, { "sim":129.0, - "partner":"3v6e" + "partner":"3olm" }, { "sim":129.0, - "partner":"8t3e" + "partner":"3v6e" }, { "sim":129.0, - "partner":"8p9a" + "partner":"5jus" }, { "sim":129.0, - "partner":"5jus" + "partner":"8t3e" }, { "sim":129.0, @@ -221203,10 +221769,6 @@ "sim":129.0, "partner":"4v91" }, - { - "sim":129.0, - "partner":"8t2x" - }, { "sim":129.0, "partner":"3j6x" @@ -221221,7 +221783,11 @@ }, { "sim":129.0, - "partner":"8t2z" + "partner":"8t2x" + }, + { + "sim":129.0, + "partner":"8p9a" }, { "sim":129.0, @@ -221229,7 +221795,7 @@ }, { "sim":129.0, - "partner":"8t3b" + "partner":"8t2z" }, { "sim":129.0, @@ -221237,11 +221803,11 @@ }, { "sim":129.0, - "partner":"8t3d" + "partner":"8t3b" }, { "sim":129.0, - "partner":"8t3f" + "partner":"8t3d" }, { "sim":129.0, @@ -221253,11 +221819,11 @@ }, { "sim":129.0, - "partner":"3j77" + "partner":"8t3f" }, { "sim":129.0, - "partner":"8p4v" + "partner":"3j77" }, { "sim":129.0, @@ -221281,23 +221847,27 @@ }, { "sim":129.0, - "partner":"8t2y" + "partner":"4v8z" }, { "sim":129.0, - "partner":"4v8z" + "partner":"5juo" }, { "sim":129.0, - "partner":"8t3a" + "partner":"5t6r" }, { "sim":129.0, - "partner":"5juo" + "partner":"8t2y" }, { "sim":129.0, - "partner":"5t6r" + "partner":"8p4v" + }, + { + "sim":129.0, + "partner":"8t3a" }, { "sim":129.0, @@ -221317,23 +221887,23 @@ }, { "sim":129.0, - "partner":"3jam" + "partner":"8s8k" }, { "sim":129.0, - "partner":"3jap" + "partner":"3j80" }, { "sim":129.0, - "partner":"8s8k" + "partner":"3j81" }, { "sim":129.0, - "partner":"3j80" + "partner":"3jam" }, { "sim":129.0, - "partner":"3j81" + "partner":"3jap" }, { "sim":129.0, @@ -221349,11 +221919,11 @@ }, { "sim":129.0, - "partner":"8oi5" + "partner":"8oj3" }, { "sim":129.0, - "partner":"8oj3" + "partner":"8oi5" }, { "sim":128.0, @@ -221563,10 +222133,6 @@ "sim":88.0, "partner":"3dbl" }, - { - "sim":87.0, - "partner":"1r4m" - }, { "sim":87.0, "partner":"1xt9" @@ -221583,6 +222149,10 @@ "sim":87.0, "partner":"1ndd" }, + { + "sim":87.0, + "partner":"1r4m" + }, { "sim":87.0, "partner":"2bkr" @@ -221593,11 +222163,11 @@ }, { "sim":87.0, - "partner":"4p5o" + "partner":"2nvu" }, { "sim":87.0, - "partner":"2nvu" + "partner":"4p5o" }, { "sim":87.0, @@ -221827,96 +222397,96 @@ ], "subtitle":"Receptor binding domain of bont\/b in complex with mini-protein binder bot.0671.2", "tags":[ + "toxin", "mini-protein binder", - "inhibitor", - "toxin" + "inhibitor" ], "keywords":[ - "orders", - "contributions", + "yeast", + "probe", "prophylactic", - "potent", + "orders", + "folding", + "model", + "dosing", + "protein", "improvement", + "binding", + "little", + "showed", + "extensive", + "novo", + "b", + "promise", + "two", + "stable", "temperatures", - "designed", - "immune", - "shapes", - "provide", - "parallel", - "target", - "extremely", - "holds", - "sequences", + "creating", + "botulinum", + "comparison", + "identified", + "enabled", + "residues", + "targets", + "subset", + "control", "bind", - "probe", - "designing", - "display", - "sequencing", - "massively", - "therapeutic", - "even", + "extremely", + "approach", "proteins", - "larger", - "investigated", - "customized", - "de", - "binder", "response", - "influenza", + "characterization", + "holds", + "shapes", + "haemagglutinin", + "binder", "small", - "integrating", + "larger", + "along", "lose", - "binders", - "little", + "computational", + "designing", + "design", "oligonucleotide", - "showed", - "extensive", - "botulinum", + "manufacturing", + "binders", + "even", + "display", + "tested", + "synthesis", + "therapeutic", + "immune", + "elicit", + "sequencing", + "parallel", "magnitude", + "customized", + "massively", "repeated", - "previously", - "control", + "describe", "screening", - "subset", - "synthesis", - "activity", - "comparison", - "design", - "model", - "characterization", - "manufacturing", - "promise", + "contributions", + "designed", + "sequences", + "unlike", + "investigated", + "evaluation", + "influenza", + "de", + "neurotoxin", + "previously", "exposure", - "describe", + "provide", + "target", + "biophysical", + "integrating", "high", - "neurotoxin", - "protection", - "dosing", + "activity", + "potent", "designs", - "tested", - "approach", - "stable", - "novo", - "sets", - "along", - "residues", - "two", - "identified", - "creating", - "evaluation", - "b", - "protein", - "targets", - "haemagglutinin", - "elicit", - "computational", - "enabled", - "unlike", - "yeast", + "protection", "antibodies", - "folding", - "binding", - "biophysical" + "sets" ], "release_date":"2017-09-20", "publication":"\"Massively parallel de novo protein design for targeted therapeutics\", Nature, 550, 74-79", @@ -222022,114 +222592,114 @@ ], "subtitle":"De novo photosynthetic reaction center protein equipped with heme b, a synthetic zn porphyrin, and zn(ii) cations", "tags":[ - "charge separation", - "artificial photosynthesis", - "maquette", "de novo protein", - "protein design" + "maquette", + "artificial photosynthesis", + "protein design", + "charge separation" ], "keywords":[ - "photochemical", - "established", - "complexes", - "catalysts", - "reconstituted", - "metal", - "cluster", - "measure", - "encumbers", - "triads", - "crystal", - "energetic", - "synthetic", - "structure", - "exceeding", - "principles", - "catalysis", - "power", - "supports", - "proteins", - "de", - "enzymes", - "elements", - "efficient", - "conversion", - "highly", "demonstrates", - "yet", - "earlier", + "engineering", + "development", "separation", - "obfuscates", - "evolutionary", + "complexes", + "clarify", + "practical", + "lead", + "framework", + "elements", + "tyrosine", + "new", + "protein", + "electron", "vitro", - "production", + "incorporates", + "essential", + "novo", "centers", - "structures", + "power", + "crystal", + "stable", + "rules", + "fragility", + "100", + "encoded", + "needed", + "obfuscates", + "lifetimes", "life", - "upon", + "reaction", + "photochemical", + "photosystem", + "shows", + "metal", + "ideal", + "efforts", "capture", - "lead", + "charge", + "transient", + "proteins", + "earlier", + "enzymes", "center", - "genetically", - "natural", - "complexity", - "essential", - "biology", - "shows", - "rules", - "framework", - "reengineering", - "generation", - "100", - "report", - "solar", - "photosynthetic", - "artificial", + "modular", "may", - "simplified", + "conversion", + "highly", + "established", + "solar", + "oxidation", + "catalysts", "redox", - "activity", - "transfer", - "engineering", "design", - "tyrosine", - "incorporates", - "transient", - "absorption", - "underlying", - "encoded", "energy", + "principles", + "spectroscopy", + "energetic", + "natural", + "biology", + "yet", "fuel", - "builds", - "build", - "clarify", "sunlight", - "novo", - "stable", - "efforts", - "rational", - "modified", + "complexity", + "measure", "carry", - "charge", - "electron", - "modular", - "spectroscopy", - "reaction", - "oxidation", - "needed", - "fragility", - "guidelines", - "interchangeable", - "legacy", - "ideal", - "protein", - "development", - "ms", + "exceeding", + "build", + "absorption", "earth", - "practical", - "photosystem", - "new", - "lifetimes" + "encumbers", + "underlying", + "upon", + "reconstituted", + "simplified", + "catalysis", + "production", + "evolutionary", + "ms", + "generation", + "efficient", + "legacy", + "reengineering", + "structures", + "de", + "rational", + "photosynthetic", + "interchangeable", + "structure", + "synthetic", + "report", + "supports", + "guidelines", + "genetically", + "artificial", + "cluster", + "modified", + "builds", + "activity", + "triads", + "transfer" ], "release_date":"2018-04-25", "publication":"\"De novo protein design of photochemical reaction centers\", Nat Commun, 13, 4937-4937", @@ -222162,11 +222732,11 @@ "seq_thr_sim_designed":[ { "sim":351.0, - "partner":"8d9o" + "partner":"5vjt" }, { "sim":351.0, - "partner":"5vjt" + "partner":"8d9o" }, { "sim":351.0, @@ -222188,11 +222758,11 @@ "seq_thr_sim_natural":[ { "sim":66.0, - "partner":"1u7m" + "partner":"1mft" }, { "sim":66.0, - "partner":"1mft" + "partner":"1u7m" }, { "sim":64.0, @@ -222218,11 +222788,11 @@ ], "seq_max_sim_designed":{ "sim":351.0, - "partner":"8d9o" + "partner":"5vjt" }, "seq_max_sim_natural":{ "sim":66.0, - "partner":"1u7m" + "partner":"1mft" }, "struct_max_sim_designed":{ "sim":0.9853000045, @@ -222284,114 +222854,114 @@ ], "subtitle":"De novo photosynthetic reaction center protein equipped with heme b and zn(ii) cations", "tags":[ - "charge separation", - "artificial photosynthesis", - "maquette", "de novo protein", - "protein design" + "maquette", + "artificial photosynthesis", + "protein design", + "charge separation" ], "keywords":[ - "photochemical", - "established", - "complexes", - "catalysts", - "reconstituted", - "metal", - "cluster", - "measure", - "encumbers", - "triads", - "crystal", - "energetic", - "synthetic", - "structure", - "exceeding", - "principles", - "catalysis", - "power", - "supports", - "proteins", - "de", - "enzymes", - "elements", - "efficient", - "conversion", - "highly", "demonstrates", - "yet", - "earlier", + "engineering", + "development", "separation", - "obfuscates", - "evolutionary", + "complexes", + "clarify", + "practical", + "lead", + "framework", + "elements", + "tyrosine", + "new", + "protein", + "electron", "vitro", - "production", + "incorporates", + "essential", + "novo", "centers", - "structures", + "power", + "crystal", + "stable", + "rules", + "fragility", + "100", + "encoded", + "needed", + "obfuscates", + "lifetimes", "life", - "upon", + "reaction", + "photochemical", + "photosystem", + "shows", + "metal", + "ideal", + "efforts", "capture", - "lead", + "charge", + "transient", + "proteins", + "earlier", + "enzymes", "center", - "genetically", - "natural", - "complexity", - "essential", - "biology", - "shows", - "rules", - "framework", - "reengineering", - "generation", - "100", - "report", - "solar", - "photosynthetic", - "artificial", + "modular", "may", - "simplified", + "conversion", + "highly", + "established", + "solar", + "oxidation", + "catalysts", "redox", - "activity", - "transfer", - "engineering", "design", - "tyrosine", - "incorporates", - "transient", - "absorption", - "underlying", - "encoded", "energy", + "principles", + "spectroscopy", + "energetic", + "natural", + "biology", + "yet", "fuel", - "builds", - "build", - "clarify", "sunlight", - "novo", - "stable", - "efforts", - "rational", - "modified", + "complexity", + "measure", "carry", - "charge", - "electron", - "modular", - "spectroscopy", - "reaction", - "oxidation", - "needed", - "fragility", - "guidelines", - "interchangeable", - "legacy", - "ideal", - "protein", - "development", - "ms", + "exceeding", + "build", + "absorption", "earth", - "practical", - "photosystem", - "new", - "lifetimes" + "encumbers", + "underlying", + "upon", + "reconstituted", + "simplified", + "catalysis", + "production", + "evolutionary", + "ms", + "generation", + "efficient", + "legacy", + "reengineering", + "structures", + "de", + "rational", + "photosynthetic", + "interchangeable", + "structure", + "synthetic", + "report", + "supports", + "guidelines", + "genetically", + "artificial", + "cluster", + "modified", + "builds", + "activity", + "triads", + "transfer" ], "release_date":"2018-04-25", "publication":"\"De novo protein design of photochemical reaction centers\", Nat Commun, 13, 4937-4937", @@ -222424,15 +222994,15 @@ "seq_thr_sim_designed":[ { "sim":351.0, - "partner":"8d9o" + "partner":"5vjs" }, { "sim":351.0, - "partner":"8d9p" + "partner":"8d9o" }, { "sim":351.0, - "partner":"5vjs" + "partner":"8d9p" }, { "sim":346.0, @@ -222450,11 +223020,11 @@ "seq_thr_sim_natural":[ { "sim":66.0, - "partner":"1u7m" + "partner":"1mft" }, { "sim":66.0, - "partner":"1mft" + "partner":"1u7m" }, { "sim":64.0, @@ -222480,11 +223050,11 @@ ], "seq_max_sim_designed":{ "sim":351.0, - "partner":"8d9o" + "partner":"5vjs" }, "seq_max_sim_natural":{ "sim":66.0, - "partner":"1u7m" + "partner":"1mft" }, "struct_max_sim_designed":{ "sim":0.9842000008, @@ -222546,114 +223116,114 @@ ], "subtitle":"De novo photosynthetic reaction center protein variant equipped with his-tyr h-bond, heme b, and cd(ii) ions", "tags":[ - "charge separation", - "artificial photosynthesis", - "maquette", "de novo protein", - "protein design" + "maquette", + "artificial photosynthesis", + "protein design", + "charge separation" ], "keywords":[ - "photochemical", - "established", - "complexes", - "catalysts", - "reconstituted", - "metal", - "cluster", - "measure", - "encumbers", - "triads", - "crystal", - "energetic", - "synthetic", - "structure", - "exceeding", - "principles", - "catalysis", - "power", - "supports", - "proteins", - "de", - "enzymes", - "elements", - "efficient", - "conversion", - "highly", "demonstrates", - "yet", - "earlier", + "engineering", + "development", "separation", - "obfuscates", - "evolutionary", + "complexes", + "clarify", + "practical", + "lead", + "framework", + "elements", + "tyrosine", + "new", + "protein", + "electron", "vitro", - "production", + "incorporates", + "essential", + "novo", "centers", - "structures", + "power", + "crystal", + "stable", + "rules", + "fragility", + "100", + "encoded", + "needed", + "obfuscates", + "lifetimes", "life", - "upon", + "reaction", + "photochemical", + "photosystem", + "shows", + "metal", + "ideal", + "efforts", "capture", - "lead", + "charge", + "transient", + "proteins", + "earlier", + "enzymes", "center", - "genetically", - "natural", - "complexity", - "essential", - "biology", - "shows", - "rules", - "framework", - "reengineering", - "generation", - "100", - "report", - "solar", - "photosynthetic", - "artificial", + "modular", "may", - "simplified", + "conversion", + "highly", + "established", + "solar", + "oxidation", + "catalysts", "redox", - "activity", - "transfer", - "engineering", "design", - "tyrosine", - "incorporates", - "transient", - "absorption", - "underlying", - "encoded", "energy", + "principles", + "spectroscopy", + "energetic", + "natural", + "biology", + "yet", "fuel", - "builds", - "build", - "clarify", "sunlight", - "novo", - "stable", - "efforts", - "rational", - "modified", + "complexity", + "measure", "carry", - "charge", - "electron", - "modular", - "spectroscopy", - "reaction", - "oxidation", - "needed", - "fragility", - "guidelines", - "interchangeable", - "legacy", - "ideal", - "protein", - "development", - "ms", + "exceeding", + "build", + "absorption", "earth", - "practical", - "photosystem", - "new", - "lifetimes" + "encumbers", + "underlying", + "upon", + "reconstituted", + "simplified", + "catalysis", + "production", + "evolutionary", + "ms", + "generation", + "efficient", + "legacy", + "reengineering", + "structures", + "de", + "rational", + "photosynthetic", + "interchangeable", + "structure", + "synthetic", + "report", + "supports", + "guidelines", + "genetically", + "artificial", + "cluster", + "modified", + "builds", + "activity", + "triads", + "transfer" ], "release_date":"2018-04-25", "publication":"\"De novo protein design of photochemical reaction centers\", Nat Commun, 13, 4937-4937", @@ -222686,7 +223256,7 @@ "seq_thr_sim_designed":[ { "sim":348.0, - "partner":"8d9o" + "partner":"5vjs" }, { "sim":348.0, @@ -222694,11 +223264,11 @@ }, { "sim":348.0, - "partner":"8d9p" + "partner":"8d9o" }, { "sim":348.0, - "partner":"5vjs" + "partner":"8d9p" }, { "sim":81.0, @@ -222720,11 +223290,11 @@ }, { "sim":64.0, - "partner":"1u7m" + "partner":"1mft" }, { "sim":64.0, - "partner":"1mft" + "partner":"1u7m" }, { "sim":59.0, @@ -222739,7 +223309,7 @@ ], "seq_max_sim_designed":{ "sim":348.0, - "partner":"8d9o" + "partner":"5vjs" }, "seq_max_sim_natural":{ "sim":68.0, @@ -222910,99 +223480,99 @@ ], "subtitle":"Computationally designed inhibitor peptide hb1.6928.2.3 in complex with influenza hemagglutinin (a\/puertorico\/8\/1934)", "tags":[ + "hemagglutinin", + "viral protein\/de novo protein", + "viral protein-de novo protein complex", "inhibitor", "influenza", - "protein design", - "viral protein-de novo protein complex", - "viral protein\/de novo protein", - "hemagglutinin" + "protein design" ], "keywords":[ - "orders", - "contributions", + "yeast", + "probe", "prophylactic", - "potent", + "orders", + "folding", + "model", + "dosing", + "protein", "improvement", + "binding", + "little", + "showed", + "extensive", + "novo", + "b", + "promise", + "two", + "stable", "temperatures", - "designed", - "immune", - "shapes", - "provide", - "parallel", - "target", - "extremely", - "holds", - "sequences", + "creating", + "botulinum", + "comparison", + "identified", + "enabled", + "residues", + "targets", + "subset", + "control", "bind", - "probe", - "designing", - "display", - "sequencing", - "massively", - "therapeutic", - "even", + "extremely", + "approach", "proteins", - "larger", - "investigated", - "customized", - "de", - "binder", "response", - "influenza", + "characterization", + "holds", + "shapes", + "haemagglutinin", + "binder", "small", - "integrating", + "larger", + "along", "lose", - "binders", - "little", + "computational", + "designing", + "design", "oligonucleotide", - "showed", - "extensive", - "botulinum", + "manufacturing", + "binders", + "even", + "display", + "tested", + "synthesis", + "therapeutic", + "immune", + "elicit", + "sequencing", + "parallel", "magnitude", + "customized", + "massively", "repeated", - "previously", - "control", + "describe", "screening", - "subset", - "synthesis", - "activity", - "comparison", - "design", - "model", - "characterization", - "manufacturing", - "promise", + "contributions", + "designed", + "sequences", + "unlike", + "investigated", + "evaluation", + "influenza", + "de", + "neurotoxin", + "previously", "exposure", - "describe", + "provide", + "target", + "biophysical", + "integrating", "high", - "neurotoxin", - "protection", - "dosing", + "activity", + "potent", "designs", - "tested", - "approach", - "stable", - "novo", - "sets", - "along", - "residues", - "two", - "identified", - "creating", - "evaluation", - "b", - "protein", - "targets", - "haemagglutinin", - "elicit", - "computational", - "enabled", - "unlike", - "yeast", + "protection", "antibodies", - "folding", - "binding", - "biophysical" + "sets" ], "release_date":"2017-09-27", "publication":"\"Massively parallel de novo protein design for targeted therapeutics\", Nature, 550, 74-79", @@ -223207,96 +223777,96 @@ ], "subtitle":"Receptor binding domain of bont\/b in complex with mini-protein binder bot.2110.4", "tags":[ + "toxin", "mini-protein binder", - "inhibitor", - "toxin" + "inhibitor" ], "keywords":[ - "orders", - "contributions", + "yeast", + "probe", "prophylactic", - "potent", + "orders", + "folding", + "model", + "dosing", + "protein", "improvement", + "binding", + "little", + "showed", + "extensive", + "novo", + "b", + "promise", + "two", + "stable", "temperatures", - "designed", - "immune", - "shapes", - "provide", - "parallel", - "target", - "extremely", - "holds", - "sequences", + "creating", + "botulinum", + "comparison", + "identified", + "enabled", + "residues", + "targets", + "subset", + "control", "bind", - "probe", - "designing", - "display", - "sequencing", - "massively", - "therapeutic", - "even", + "extremely", + "approach", "proteins", - "larger", - "investigated", - "customized", - "de", - "binder", "response", - "influenza", + "characterization", + "holds", + "shapes", + "haemagglutinin", + "binder", "small", - "integrating", + "larger", + "along", "lose", - "binders", - "little", + "computational", + "designing", + "design", "oligonucleotide", - "showed", - "extensive", - "botulinum", + "manufacturing", + "binders", + "even", + "display", + "tested", + "synthesis", + "therapeutic", + "immune", + "elicit", + "sequencing", + "parallel", "magnitude", + "customized", + "massively", "repeated", - "previously", - "control", + "describe", "screening", - "subset", - "synthesis", - "activity", - "comparison", - "design", - "model", - "characterization", - "manufacturing", - "promise", + "contributions", + "designed", + "sequences", + "unlike", + "investigated", + "evaluation", + "influenza", + "de", + "neurotoxin", + "previously", "exposure", - "describe", + "provide", + "target", + "biophysical", + "integrating", "high", - "neurotoxin", - "protection", - "dosing", + "activity", + "potent", "designs", - "tested", - "approach", - "stable", - "novo", - "sets", - "along", - "residues", - "two", - "identified", - "creating", - "evaluation", - "b", - "protein", - "targets", - "haemagglutinin", - "elicit", - "computational", - "enabled", - "unlike", - "yeast", + "protection", "antibodies", - "folding", - "binding", - "biophysical" + "sets" ], "release_date":"2017-09-20", "publication":"\"Massively parallel de novo protein design for targeted therapeutics\", Nature, 550, 74-79", @@ -223422,94 +223992,94 @@ ], "subtitle":"Fibrils of the super helical repeat peptide, shr-ff, grown at elevated temperature", "tags":[ - "fibril", "de novo protein", - "de novo design" + "de novo design", + "fibril" ], "keywords":[ - "minima", - "evidence", + "gatekeeper", "steric", - "fortunately", - "concentration", - "time", - "peptide", + "minimum", + "resolution", + "amyloidogenic", + "establishes", "barrier", - "designed", - "value", - "principal", - "transformation", - "potential", - "exist", - "ii", - "sizable", - "represent", - "structure", - "zipper", - "dry", - "recently", - "turn", + "protein", + "study", + "plane", + "polymorphism", + "given", + "little", + "novo", + "demonstrate", + "related", + "stable", + "secondary", + "global", "however", - "gatekeeper", + "thermodynamically", + "value", + "reaches", + "furthermore", + "transition", + "folded", "proteins", "process", - "de", - "amyloidogenic", - "conversion", - "serve", - "little", - "often", - "folded", - "furthermore", - "fibrillar", + "evidence", + "concentration", + "minima", "metastable", - "facilitates", + "zipper", + "ensemble", + "fortunately", + "peptide", + "critical", + "energy", + "indications", "atomic", - "assembly", - "minimum", - "native", - "revealed", - "thermodynamically", - "transition", "impedes", + "represent", + "potential", + "assembly", + "addition", + "considered", + "sizable", + "type", "pathogenic", - "first", - "heptapeptide", - "associated", + "fibrils", + "time", + "sequence", + "states", + "dry", "common", - "report", - "resolution", - "flip", - "indications", - "polymorphism", - "type", + "crystals", + "associated", + "exist", + "fibrillar", + "designed", + "often", + "revealed", + "heptapeptide", "deeper", - "states", - "secondary", - "sequence", - "reaches", - "energy", - "ensemble", + "de", + "principal", + "first", + "flip", + "structure", + "report", + "serve", + "recently", + "transformation", + "state", "known", - "demonstrate", + "facilitates", + "native", + "amyloid", "deposits", - "critical", - "study", - "stable", - "novo", - "plane", - "fibrils", + "turn", "discovery", - "establishes", - "state", - "addition", - "considered", - "amyloid", - "protein", - "given", - "global", - "related", - "crystals" + "conversion", + "ii" ], "release_date":"2018-06-27", "publication":"\"Transition of Metastable Cross-alpha Crystals into Cross-beta Fibrils by beta-Turn Flipping\", J.Am.Chem.Soc., 141, 363-369", @@ -223607,116 +224177,116 @@ ], "subtitle":"Hetero antiparallel coiled coil hexamer formed by de novo peptides", "tags":[ + "de novo", "antiparallel", "de novo protein", - "de novo", "phe-ile zipper", "hexamer" ], "keywords":[ - "analysis", - "represents", + "finally", "steric", - "hexamer", - "scattering", - "ile", + "hydrophobic", + "probe", + "additional", + "core", + "side", + "w", "acid", - "peptide", - "designed", - "enhance", - "sensitive", + "within", + "residue", + "exhibits", + "significantly", + "positions", + "salt", + "changes", + "motif", + "generality", + "forms", + "maximizing", + "adjacent", + "using", + "similar", "robust", - "mutations", + "creating", + "supramolecular", + "antiparallel", + "enhance", + "bridging", + "formed", + "limits", + "bulk", + "represents", + "exclusion", + "biological", + "residues", + "discovered", + "specific", + "exploring", + "stability", "interact", - "utilizing", - "sequences", - "interactions", - "probe", - "topologically", - "chromatography", - "affected", - "structure", + "size", + "scattering", + "found", + "\u03b4g", "zipper", - "recently", - "bulk", - "hydrophobicity", - "expanding", + "unprecedented", + "coils", + "introduced", + "bundle", + "1", + "peptide", "direct", - "interaction", - "coiled", - "generating", + "atomistically", + "relies", + "subtle", "chain", - "unique", - "similar", - "variants", - "finally", + "expanded", "suggests", - "motif", - "materials", - "w", - "structures", - "positions", - "mol", - "kcal", + "functional", "natural", - "coils", + "proper", + "kcal", "assembly", - "size", - "significantly", - "form", - "additional", - "discovered", - "exploring", "properties", - "stability", - "salt", "monomers", - "powerful", - "bridging", - "u", - "functional", + "tool", + "hydrophobicity", "amino", - "atomistically", - "exhibits", - "proper", - "changes", + "mol", + "chromatography", + "ile", + "interaction", "unnatural", - "1", - "acids", - "placed", - "limits", - "specific", - "bundle", - "introduced", - "crystallographic", - "core", - "using", - "hydrophobic", - "\u03b4g", "sequence", - "biological", - "exclusion", - "generality", - "relies", - "supramolecular", - "maximizing", - "subtle", - "unprecedented", - "understand", - "residues", - "found", - "adjacent", - "antiparallel", "system", - "creating", - "residue", + "generating", + "expanding", + "topologically", + "unique", + "materials", + "crystallographic", + "hexamer", + "designed", + "form", + "analysis", + "sequences", + "u", + "mutations", + "variants", + "structures", + "understand", + "structure", + "affected", + "powerful", + "recently", + "interactions", + "placed", + "coiled", "phe", - "within", - "side", - "expanded", - "formed", - "forms", - "tool" + "utilizing", + "acids", + "sensitive" ], "release_date":"2017-10-04", "publication":"\"The Phe-Ile Zipper: A Specific Interaction Motif Drives Antiparallel Coiled-Coil Hexamer Formation\", Biochemistry, 56, 5300-5308", @@ -223762,164 +224332,160 @@ "partner":"5eon" }, { - "sim":1.0, - "partner":"3r3k" + "sim":0.9761999846, + "partner":"6q5r" }, { - "sim":1.0, - "partner":"4h8g" + "sim":0.9710999727, + "partner":"6q5q" }, { - "sim":0.9937000275, - "partner":"6q5n" + "sim":0.9983000159, + "partner":"6q5s" }, { - "sim":0.9983999729, - "partner":"6q5p" + "sim":1.0, + "partner":"3r3k" }, { - "sim":1.0, - "partner":"4h8m" + "sim":0.9695000052, + "partner":"8a3g" }, { "sim":1.0, - "partner":"3r46" + "partner":"8qac" }, { - "sim":0.9983000159, - "partner":"3r48" + "sim":1.0, + "partner":"4h8g" }, { - "sim":0.997600019, - "partner":"6q5o" + "sim":0.9937000275, + "partner":"6q5n" }, { - "sim":0.9983000159, - "partner":"6q5j" + "sim":1.0, + "partner":"4h8m" }, { - "sim":1.0, - "partner":"4h7r" + "sim":0.997600019, + "partner":"6q5o" }, { - "sim":0.9761999846, - "partner":"4h8f" + "sim":0.9983999729, + "partner":"6q5p" }, { "sim":0.9983000159, - "partner":"6q5s" + "partner":"3r48" }, { - "sim":0.9559999704, - "partner":"3r47" + "sim":1.0, + "partner":"3r46" }, { - "sim":0.9987000227, - "partner":"4h8o" + "sim":0.9745000005, + "partner":"4pn8" }, { - "sim":0.9695000052, - "partner":"8a3g" + "sim":0.9983000159, + "partner":"6q5j" }, { "sim":1.0, - "partner":"8qac" + "partner":"4h7r" }, { "sim":0.9761999846, - "partner":"6q5r" - }, - { - "sim":0.9710999727, - "partner":"6q5q" + "partner":"4h8f" }, { "sim":0.9761999846, - "partner":"8qaa" + "partner":"6v5j" }, { - "sim":0.9965999722, - "partner":"3r4a" + "sim":0.9761999846, + "partner":"6q1w" }, { - "sim":0.9973000288, - "partner":"3r4h" + "sim":0.9761999846, + "partner":"8qaa" }, { - "sim":0.996900022, - "partner":"4dzl" + "sim":0.9987000227, + "partner":"2jgo" }, { - "sim":0.9749000072, - "partner":"8qab" + "sim":0.9990000129, + "partner":"3ljm" }, { - "sim":0.9871000051, - "partner":"1cos" + "sim":0.9559999704, + "partner":"3r47" }, { - "sim":0.9987000227, - "partner":"2jgo" + "sim":0.9818000197, + "partner":"5uxt" }, { - "sim":0.9904999733, - "partner":"2x6p" + "sim":0.9973000288, + "partner":"3r4h" }, { - "sim":0.9990000129, - "partner":"3ljm" + "sim":0.9715999961, + "partner":"6q25" }, { - "sim":1.0, - "partner":"5k92" + "sim":0.9711999893, + "partner":"6u47" }, { - "sim":0.9980999827, - "partner":"5u9t" + "sim":0.9736999869, + "partner":"6v58" }, { - "sim":0.9875000119, - "partner":"5u9u" + "sim":0.9871000051, + "partner":"1cos" }, { - "sim":0.9745000005, - "partner":"4pn8" + "sim":0.9761999846, + "partner":"6v50" }, { "sim":0.9761999846, - "partner":"6v5j" + "partner":"6ovs" }, { - "sim":0.9761999846, - "partner":"6q1w" + "sim":1.0, + "partner":"5k92" }, { - "sim":0.9818000197, - "partner":"5uxt" + "sim":0.9965999722, + "partner":"3r4a" }, { - "sim":0.9715999961, - "partner":"6q25" + "sim":0.9987000227, + "partner":"4h8o" }, { - "sim":0.9711999893, - "partner":"6u47" + "sim":0.9749000072, + "partner":"8qab" }, { - "sim":0.9736999869, - "partner":"6v58" + "sim":0.9710999727, + "partner":"5kb1" }, { - "sim":0.9761999846, - "partner":"6v50" + "sim":0.9904999733, + "partner":"2x6p" }, { - "sim":0.9761999846, - "partner":"6ovs" + "sim":0.9980999827, + "partner":"5u9t" }, { - "sim":0.9710999727, - "partner":"5kb1" + "sim":0.9875000119, + "partner":"5u9u" }, { "sim":0.9740999937, @@ -223936,6 +224502,10 @@ { "sim":0.996900022, "partner":"5kb0" + }, + { + "sim":0.996900022, + "partner":"4dzl" } ], "struct_thr_sim_natural":[ @@ -223960,7 +224530,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"4h8m" + "partner":"3r3k" }, "struct_max_sim_natural":{ "sim":1.0, @@ -224002,116 +224572,116 @@ ], "subtitle":"Antiparallel coiled coil hexamer formed by de novo peptides (acc-hex2)", "tags":[ + "de novo", "antiparallel", "de novo protein", - "de novo", "phe-ile zipper", "hexamer" ], "keywords":[ - "analysis", - "represents", + "finally", "steric", - "hexamer", - "scattering", - "ile", + "hydrophobic", + "probe", + "additional", + "core", + "side", + "w", "acid", - "peptide", - "designed", - "enhance", - "sensitive", + "within", + "residue", + "exhibits", + "significantly", + "positions", + "salt", + "changes", + "motif", + "generality", + "forms", + "maximizing", + "adjacent", + "using", + "similar", "robust", - "mutations", + "creating", + "supramolecular", + "antiparallel", + "enhance", + "bridging", + "formed", + "limits", + "bulk", + "represents", + "exclusion", + "biological", + "residues", + "discovered", + "specific", + "exploring", + "stability", "interact", - "utilizing", - "sequences", - "interactions", - "probe", - "topologically", - "chromatography", - "affected", - "structure", + "size", + "scattering", + "found", + "\u03b4g", "zipper", - "recently", - "bulk", - "hydrophobicity", - "expanding", + "unprecedented", + "coils", + "introduced", + "bundle", + "1", + "peptide", "direct", - "interaction", - "coiled", - "generating", + "atomistically", + "relies", + "subtle", "chain", - "unique", - "similar", - "variants", - "finally", + "expanded", "suggests", - "motif", - "materials", - "w", - "structures", - "positions", - "mol", - "kcal", + "functional", "natural", - "coils", + "proper", + "kcal", "assembly", - "size", - "significantly", - "form", - "additional", - "discovered", - "exploring", "properties", - "stability", - "salt", "monomers", - "powerful", - "bridging", - "u", - "functional", + "tool", + "hydrophobicity", "amino", - "atomistically", - "exhibits", - "proper", - "changes", + "mol", + "chromatography", + "ile", + "interaction", "unnatural", - "1", - "acids", - "placed", - "limits", - "specific", - "bundle", - "introduced", - "crystallographic", - "core", - "using", - "hydrophobic", - "\u03b4g", "sequence", - "biological", - "exclusion", - "generality", - "relies", - "supramolecular", - "maximizing", - "subtle", - "unprecedented", - "understand", - "residues", - "found", - "adjacent", - "antiparallel", "system", - "creating", - "residue", + "generating", + "expanding", + "topologically", + "unique", + "materials", + "crystallographic", + "hexamer", + "designed", + "form", + "analysis", + "sequences", + "u", + "mutations", + "variants", + "structures", + "understand", + "structure", + "affected", + "powerful", + "recently", + "interactions", + "placed", + "coiled", "phe", - "within", - "side", - "expanded", - "formed", - "forms", - "tool" + "utilizing", + "acids", + "sensitive" ], "release_date":"2017-10-04", "publication":"\"The Phe-Ile Zipper: A Specific Interaction Motif Drives Antiparallel Coiled-Coil Hexamer Formation\", Biochemistry, 56, 5300-5308", @@ -224242,103 +224812,103 @@ "de novo protein" ], "keywords":[ - "work", - "utilize", - "pharmacological", - "studies", - "bonds", - "label", - "reducing", - "designed", - "determine", - "broad", - "methods", - "potential", - "expression", - "conformation", - "adopt", - "assess", - "therefore", - "represent", - "structure", + "made", "escherichia", + "molecular", "redesign", - "uniformly", - "utility", + "adopt", + "unsuccessful", + "methods", + "therefore", + "well", + "tempering", + "families", + "13", + "assess", + "new", "unstable", - "simulation", - "models", - "exhibited", + "protein", + "vitro", + "novo", + "resonance", + "two", + "recent", + "nuclear", + "stable", + "using", + "utilize", + "needed", + "simulations", + "conformation", "enables", - "de", - "produce", - "family", - "used", - "dependency", - "agreed", "initial", - "nuclear", - "vitro", - "made", + "confirming", + "exhibited", "furthermore", - "md", - "production", - "dynamics", + "family", + "protocol", + "disulfide", + "magnetic", + "stability", "calculated", - "structures", - "attempts", + "uniformly", + "accuracy", + "broad", "advantage", - "tempering", - "solution", - "resonance", - "revealed", - "likely", - "performed", - "previously", - "stability", - "reported", - "data", - "molecular", - "conditions", - "coli", - "families", - "host", - "method", - "protocol", - "simulations", + "pharmacological", + "label", + "15", + "ensemble", + "reducing", + "computational", "advances", "design", - "using", - "nmr", - "confirming", - "recent", - "describe", - "techniques", - "ensemble", - "disulfide", + "work", + "used", + "represent", + "produce", + "possible", + "potential", + "fold", + "bonds", "collection", - "important", - "unsuccessful", - "13", - "accuracy", - "designs", + "solution", + "utility", + "conditions", + "coli", "maintain", - "magnetic", - "stable", - "novo", - "fold", - "peptides", - "well", - "needed", - "two", "system", + "reported", + "peptides", + "techniques", + "describe", + "determine", + "agreed", + "method", + "dynamics", + "production", + "designed", + "models", + "revealed", + "structures", + "de", + "previously", + "performed", + "attempts", + "likely", + "important", + "structure", + "host", + "nmr", "state", - "protein", - "15", + "dependency", + "md", "isotopically", - "computational", - "possible", - "new" + "expression", + "studies", + "data", + "designs", + "simulation" ], "release_date":"2018-07-11", "publication":"\"Cytosolic expression, solution structures, and molecular dynamics simulation of genetically encodable disulfide-rich de novo designed peptides\", Protein Sci., 27, 1611-1623", @@ -224452,126 +225022,126 @@ ], "subtitle":"De novo design of polynuclear transition metal clusters in helix bundles-4eh1", "tags":[ - "de novo protein", "helical bundle", + "de novo protein", "protein design", "metal ion binding" ], "keywords":[ - "imidazole", + "liganding", "surrounding", - "multiple", "steric", - "probed", - "metal", - "ions", - "including", - "test", - "accomplished", - "designed", - "near", - "determine", + "single", + "well", + "multiple", + "varied", + "tetranuclear", + "side", + "bottom", + "within", + "affect", + "vertices", + "ligands", "cofactors", + "drive", + "network", + "flanking", + "helical", + "binding", + "changes", + "fully", + "unanticipated", + "site", + "novo", + "test", + "circular", + "two", "crystal", - "bind", - "interactions", - "designing", - "structure", + "attractive", + "chains", + "imidazole", "zn", - "16", - "bulk", - "primary", - "consistent", - "network", - "proteins", - "tetranuclear", - "asp", - "de", "reactivity", - "clusters", + "donating", "top", - "fully", - "fourth", - "site", - "drive", - "structures", + "metal", + "conformational", + "bundles", + "formed", + "bulk", + "metalloproteins", + "agreement", + "accomplished", + "distorted", + "define", + "ligand", + "overall", + "residues", + "helix", + "carboxylate", + "polar", + "transition", + "connected", + "environments", "buried", + "bind", + "approach", + "bound", + "proteins", + "sites", + "packing", + "ions", "center", - "vertices", - "solution", - "assembly", - "circular", - "ligands", - "transition", - "affect", - "properties", "analytical", - "glu", - "bottom", - "considerable", - "oxygens", - "connected", - "geometry", - "bundles", - "donating", - "changes", + "situated", + "asp", + "probed", + "stabilize", "four", - "apolar", - "define", - "carboxylate", - "agreement", - "provides", "bundle", - "stabilize", + "including", + "consists", + "designing", "design", - "helical", - "progress", - "nmr", - "describe", - "stabilized", - "flanking", - "good", - "cuboidal", - "packing", - "ion", - "distorted", - "sites", - "occupancy", - "consisting", - "ligand", - "overall", - "chains", "subtle", - "conformational", - "approach", - "novo", - "single", - "metalloproteins", - "attractive", - "ultracentrifugation", "spectroscopy", - "well", - "residues", - "unanticipated", - "two", - "environments", - "varied", - "polar", + "provides", + "apolar", + "clusters", + "consisting", + "16", + "assembly", + "properties", + "good", + "third", + "cuboidal", + "solution", + "glu", + "primary", + "oxygens", + "near", + "describe", + "determine", "mechanism", - "partial", - "cores", - "bound", + "fourth", + "ultracentrifugation", + "designed", + "geometry", + "occupancy", + "structures", + "de", + "progress", "synthesized", - "helix", - "third", - "within", - "consists", - "liganding", - "side", + "partial", + "structure", + "nmr", + "ion", + "interactions", + "considerable", "dichroism", - "situated", - "binding", - "formed" + "cores", + "stabilized", + "consistent" ], "release_date":"2018-01-03", "publication":"\"De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles\", J. Am. Chem. Soc., 140, 1294-1304", @@ -224625,11 +225195,11 @@ }, { "sim":1.0, - "partner":"5wlm" + "partner":"5wlk" }, { "sim":1.0, - "partner":"5wlk" + "partner":"5wlm" } ], "struct_thr_sim_natural":[ @@ -224706,126 +225276,126 @@ ], "subtitle":"De novo design of polynuclear transition metal clusters in helix bundles-4eh2", "tags":[ - "metal binding", - "de novo protein", "helical bundle", - "protein design" + "de novo protein", + "protein design", + "metal binding" ], "keywords":[ - "imidazole", + "liganding", "surrounding", - "multiple", "steric", - "probed", - "metal", - "ions", - "including", - "test", - "accomplished", - "designed", - "near", - "determine", + "single", + "well", + "multiple", + "varied", + "tetranuclear", + "side", + "bottom", + "within", + "affect", + "vertices", + "ligands", "cofactors", + "drive", + "network", + "flanking", + "helical", + "binding", + "changes", + "fully", + "unanticipated", + "site", + "novo", + "test", + "circular", + "two", "crystal", - "bind", - "interactions", - "designing", - "structure", + "attractive", + "chains", + "imidazole", "zn", - "16", - "bulk", - "primary", - "consistent", - "network", - "proteins", - "tetranuclear", - "asp", - "de", "reactivity", - "clusters", + "donating", "top", - "fully", - "fourth", - "site", - "drive", - "structures", + "metal", + "conformational", + "bundles", + "formed", + "bulk", + "metalloproteins", + "agreement", + "accomplished", + "distorted", + "define", + "ligand", + "overall", + "residues", + "helix", + "carboxylate", + "polar", + "transition", + "connected", + "environments", "buried", + "bind", + "approach", + "bound", + "proteins", + "sites", + "packing", + "ions", "center", - "vertices", - "solution", - "assembly", - "circular", - "ligands", - "transition", - "affect", - "properties", "analytical", - "glu", - "bottom", - "considerable", - "oxygens", - "connected", - "geometry", - "bundles", - "donating", - "changes", + "situated", + "asp", + "probed", + "stabilize", "four", - "apolar", - "define", - "carboxylate", - "agreement", - "provides", "bundle", - "stabilize", + "including", + "consists", + "designing", "design", - "helical", - "progress", - "nmr", - "describe", - "stabilized", - "flanking", - "good", - "cuboidal", - "packing", - "ion", - "distorted", - "sites", - "occupancy", - "consisting", - "ligand", - "overall", - "chains", "subtle", - "conformational", - "approach", - "novo", - "single", - "metalloproteins", - "attractive", - "ultracentrifugation", "spectroscopy", - "well", - "residues", - "unanticipated", - "two", - "environments", - "varied", - "polar", + "provides", + "apolar", + "clusters", + "consisting", + "16", + "assembly", + "properties", + "good", + "third", + "cuboidal", + "solution", + "glu", + "primary", + "oxygens", + "near", + "describe", + "determine", "mechanism", - "partial", - "cores", - "bound", + "fourth", + "ultracentrifugation", + "designed", + "geometry", + "occupancy", + "structures", + "de", + "progress", "synthesized", - "helix", - "third", - "within", - "consists", - "liganding", - "side", + "partial", + "structure", + "nmr", + "ion", + "interactions", + "considerable", "dichroism", - "situated", - "binding", - "formed" + "cores", + "stabilized", + "consistent" ], "release_date":"2018-01-03", "publication":"\"De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles\", J. Am. Chem. Soc., 140, 1294-1304", @@ -224956,126 +225526,126 @@ ], "subtitle":"De novo design of polynuclear transition metal clusters in helix bundles-4dh1", "tags":[ - "metal binding", - "de novo protein", "helical bundle", - "protein design" + "de novo protein", + "protein design", + "metal binding" ], "keywords":[ - "imidazole", + "liganding", "surrounding", - "multiple", "steric", - "probed", - "metal", - "ions", - "including", - "test", - "accomplished", - "designed", - "near", - "determine", + "single", + "well", + "multiple", + "varied", + "tetranuclear", + "side", + "bottom", + "within", + "affect", + "vertices", + "ligands", "cofactors", + "drive", + "network", + "flanking", + "helical", + "binding", + "changes", + "fully", + "unanticipated", + "site", + "novo", + "test", + "circular", + "two", "crystal", - "bind", - "interactions", - "designing", - "structure", + "attractive", + "chains", + "imidazole", "zn", - "16", - "bulk", - "primary", - "consistent", - "network", - "proteins", - "tetranuclear", - "asp", - "de", "reactivity", - "clusters", + "donating", "top", - "fully", - "fourth", - "site", - "drive", - "structures", + "metal", + "conformational", + "bundles", + "formed", + "bulk", + "metalloproteins", + "agreement", + "accomplished", + "distorted", + "define", + "ligand", + "overall", + "residues", + "helix", + "carboxylate", + "polar", + "transition", + "connected", + "environments", "buried", + "bind", + "approach", + "bound", + "proteins", + "sites", + "packing", + "ions", "center", - "vertices", - "solution", - "assembly", - "circular", - "ligands", - "transition", - "affect", - "properties", "analytical", - "glu", - "bottom", - "considerable", - "oxygens", - "connected", - "geometry", - "bundles", - "donating", - "changes", + "situated", + "asp", + "probed", + "stabilize", "four", - "apolar", - "define", - "carboxylate", - "agreement", - "provides", "bundle", - "stabilize", + "including", + "consists", + "designing", "design", - "helical", - "progress", - "nmr", - "describe", - "stabilized", - "flanking", - "good", - "cuboidal", - "packing", - "ion", - "distorted", - "sites", - "occupancy", - "consisting", - "ligand", - "overall", - "chains", "subtle", - "conformational", - "approach", - "novo", - "single", - "metalloproteins", - "attractive", - "ultracentrifugation", "spectroscopy", - "well", - "residues", - "unanticipated", - "two", - "environments", - "varied", - "polar", + "provides", + "apolar", + "clusters", + "consisting", + "16", + "assembly", + "properties", + "good", + "third", + "cuboidal", + "solution", + "glu", + "primary", + "oxygens", + "near", + "describe", + "determine", "mechanism", + "fourth", + "ultracentrifugation", + "designed", + "geometry", + "occupancy", + "structures", + "de", + "progress", + "synthesized", "partial", + "structure", + "nmr", + "ion", + "interactions", + "considerable", + "dichroism", "cores", - "bound", - "synthesized", - "helix", - "third", - "within", - "consists", - "liganding", - "side", - "dichroism", - "situated", - "binding", - "formed" + "stabilized", + "consistent" ], "release_date":"2018-01-03", "publication":"\"De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles\", J. Am. Chem. Soc., 140, 1294-1304", @@ -225121,11 +225691,11 @@ "struct_thr_sim_designed":[ { "sim":1.0, - "partner":"5wlm" + "partner":"5wlj" }, { "sim":1.0, - "partner":"5wlj" + "partner":"5wlm" }, { "sim":1.0, @@ -225144,7 +225714,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"5wlm" + "partner":"5wlj" }, "struct_max_sim_natural":[ @@ -225206,126 +225776,126 @@ ], "subtitle":"De novo design of polynuclear transition metal clusters in helix bundles-4dh2", "tags":[ - "metal binding", - "de novo protein", "helical bundle", - "protein design" + "de novo protein", + "protein design", + "metal binding" ], "keywords":[ - "imidazole", + "liganding", "surrounding", - "multiple", "steric", - "probed", - "metal", - "ions", - "including", - "test", - "accomplished", - "designed", - "near", - "determine", + "single", + "well", + "multiple", + "varied", + "tetranuclear", + "side", + "bottom", + "within", + "affect", + "vertices", + "ligands", "cofactors", + "drive", + "network", + "flanking", + "helical", + "binding", + "changes", + "fully", + "unanticipated", + "site", + "novo", + "test", + "circular", + "two", "crystal", - "bind", - "interactions", - "designing", - "structure", + "attractive", + "chains", + "imidazole", "zn", - "16", - "bulk", - "primary", - "consistent", - "network", - "proteins", - "tetranuclear", - "asp", - "de", "reactivity", - "clusters", + "donating", "top", - "fully", - "fourth", - "site", - "drive", - "structures", + "metal", + "conformational", + "bundles", + "formed", + "bulk", + "metalloproteins", + "agreement", + "accomplished", + "distorted", + "define", + "ligand", + "overall", + "residues", + "helix", + "carboxylate", + "polar", + "transition", + "connected", + "environments", "buried", + "bind", + "approach", + "bound", + "proteins", + "sites", + "packing", + "ions", "center", - "vertices", - "solution", - "assembly", - "circular", - "ligands", - "transition", - "affect", - "properties", "analytical", - "glu", - "bottom", - "considerable", - "oxygens", - "connected", - "geometry", - "bundles", - "donating", - "changes", + "situated", + "asp", + "probed", + "stabilize", "four", - "apolar", - "define", - "carboxylate", - "agreement", - "provides", "bundle", - "stabilize", + "including", + "consists", + "designing", "design", - "helical", - "progress", - "nmr", - "describe", - "stabilized", - "flanking", - "good", - "cuboidal", - "packing", - "ion", - "distorted", - "sites", - "occupancy", - "consisting", - "ligand", - "overall", - "chains", "subtle", - "conformational", - "approach", - "novo", - "single", - "metalloproteins", - "attractive", - "ultracentrifugation", "spectroscopy", - "well", - "residues", - "unanticipated", - "two", - "environments", - "varied", - "polar", + "provides", + "apolar", + "clusters", + "consisting", + "16", + "assembly", + "properties", + "good", + "third", + "cuboidal", + "solution", + "glu", + "primary", + "oxygens", + "near", + "describe", + "determine", "mechanism", - "partial", - "cores", - "bound", + "fourth", + "ultracentrifugation", + "designed", + "geometry", + "occupancy", + "structures", + "de", + "progress", "synthesized", - "helix", - "third", - "within", - "consists", - "liganding", - "side", + "partial", + "structure", + "nmr", + "ion", + "interactions", + "considerable", "dichroism", - "situated", - "binding", - "formed" + "cores", + "stabilized", + "consistent" ], "release_date":"2018-01-03", "publication":"\"De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles\", J. Am. Chem. Soc., 140, 1294-1304", @@ -225471,96 +226041,96 @@ ], "subtitle":"De novo design of covalently constrained meso-size protein scaffolds with unique tertiary structures", "tags":[ + "covalent constrained peptide", "de novo protein", - "de novo design", - "covalent constrained peptide" + "de novo design" ], "keywords":[ - "part", - "use", - "developing", - "metal", - "selection", - "crystallography", - "including", - "designed", - "provide", - "determined", - "versatile", - "interactions", - "structure", - "inhibitors", - "general", - "restraints", - "prepared", - "proteins", - "mesosized", - "unique", - "de", - "biosynthetic", - "typically", - "successfully", - "small", - "easily", - "nature", - "structures", "templates", - "predictable", - "natural", - "solution", - "tertiary", - "macrocyclic", - "alternatively", + "defined", "ease", + "hydrophobic", + "around", + "core", + "macrocyclic", + "biosynthetic", + "developing", + "folding", + "bicyclic", + "protein", + "successfully", + "binding", + "general", + "novo", "motifs", + "agent", "either", - "form", - "covcore", + "tertiary", + "typically", + "terms", + "metal", + "ones", + "predictable", + "prepared", + "accessible", + "disulfide", + "approach", + "proteins", "large", + "packing", + "part", + "use", "multivalent", - "defined", + "small", + "found", + "conventional", + "bond", "chemical", - "bicyclic", - "apolar", - "method", - "synthesis", "stabilize", + "computational", + "including", + "relies", + "covcore", "design", - "core", - "agent", - "bond", - "hydrophobic", - "nmr", + "mesosized", + "selection", + "natural", + "apolar", "precursors", + "rosetta", + "fold", + "synthesis", + "also", + "easily", "lying", - "indicate", + "solution", "formation", - "disulfide", - "around", - "packing", - "conventional", - "integral", - "ones", - "3d", - "relies", - "accessible", - "approach", - "also", - "novo", + "incorporating", "contrast", - "rosetta", - "fold", + "versatile", "peptides", - "found", - "terms", - "folds", - "incorporating", - "protein", - "computational", - "folding", - "binding", "developed", - "libraries" + "3d", + "unique", + "method", + "folds", + "designed", + "form", + "indicate", + "structures", + "de", + "integral", + "structure", + "provide", + "determined", + "crystallography", + "nmr", + "interactions", + "nature", + "inhibitors", + "alternatively", + "libraries", + "restraints" ], "release_date":"2017-10-04", "publication":"\"De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures\", Proc. Natl. Acad. Sci. U.S.A., 114, 10852-10857", @@ -225688,96 +226258,96 @@ ], "subtitle":"De novo design of covalently constrained meso-size protein scaffolds with unique tertiary structures", "tags":[ + "covalent constrained peptide", "de novo protein", - "de novo design", - "covalent constrained peptide" + "de novo design" ], "keywords":[ - "part", - "use", - "developing", - "metal", - "selection", - "crystallography", - "including", - "designed", - "provide", - "determined", - "versatile", - "interactions", - "structure", - "inhibitors", - "general", - "restraints", - "prepared", - "proteins", - "mesosized", - "unique", - "de", - "biosynthetic", - "typically", - "successfully", - "small", - "easily", - "nature", - "structures", "templates", - "predictable", - "natural", - "solution", - "tertiary", - "macrocyclic", - "alternatively", + "defined", "ease", + "hydrophobic", + "around", + "core", + "macrocyclic", + "biosynthetic", + "developing", + "folding", + "bicyclic", + "protein", + "successfully", + "binding", + "general", + "novo", "motifs", + "agent", "either", - "form", - "covcore", + "tertiary", + "typically", + "terms", + "metal", + "ones", + "predictable", + "prepared", + "accessible", + "disulfide", + "approach", + "proteins", "large", + "packing", + "part", + "use", "multivalent", - "defined", + "small", + "found", + "conventional", + "bond", "chemical", - "bicyclic", - "apolar", - "method", - "synthesis", "stabilize", + "computational", + "including", + "relies", + "covcore", "design", - "core", - "agent", - "bond", - "hydrophobic", - "nmr", + "mesosized", + "selection", + "natural", + "apolar", "precursors", + "rosetta", + "fold", + "synthesis", + "also", + "easily", "lying", - "indicate", + "solution", "formation", - "disulfide", - "around", - "packing", - "conventional", - "integral", - "ones", - "3d", - "relies", - "accessible", - "approach", - "also", - "novo", + "incorporating", "contrast", - "rosetta", - "fold", + "versatile", "peptides", - "found", - "terms", - "folds", - "incorporating", - "protein", - "computational", - "folding", - "binding", "developed", - "libraries" + "3d", + "unique", + "method", + "folds", + "designed", + "form", + "indicate", + "structures", + "de", + "integral", + "structure", + "provide", + "determined", + "crystallography", + "nmr", + "interactions", + "nature", + "inhibitors", + "alternatively", + "libraries", + "restraints" ], "release_date":"2017-10-04", "publication":"\"De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures\", Proc. Natl. Acad. Sci. U.S.A., 114, 10852-10857", @@ -225890,128 +226460,128 @@ ], "subtitle":"Vg13p structure in lps", "tags":[ - "antimicrobial peptide", - "turn and loop-like structure", + "endotoxin neutralisation", "de novo protein, antimicrobial protein", - "de novo protein", "antimicrobial protein", - "endotoxin neutralisation" + "de novo protein", + "turn and loop-like structure", + "antimicrobial peptide" ], "keywords":[ - "consecutive", - "remained", - "gene", - "lys6gly", - "peptide", - "lipopolysaccharide", - "allowing", - "designed", - "analogue", - "interact", - "mutation", - "improved", - "outer", - "expression", + "uninterrupted", + "role", + "hydrophobic", + "well", "closer", - "enhanced", - "accounts", - "reduction", + "retains", + "vg16krkp", + "three", + "lipopolysaccharide", + "via", + "truncation", + "lys6gly", + "chair", + "vargwkrkcplfgkgg", + "study", + "vitro", + "binding", + "bacterial", + "together", + "removal", "antibacterial", - "structure", - "16", - "turn", - "strengthened", - "crucial", - "interaction", - "suggesting", - "membrane", + "leu11", + "major", + "parent", + "line", + "two", + "region", + "accounts", + "gly4", "play", - "resembling", - "unique", - "cell", + "component", + "analogue", "almost", - "lps", + "gene", + "ala2", + "residues", + "crucial", + "unhindered", "rocking", - "back", - "vitro", - "removal", - "forming", - "14", + "unchanged", + "last", + "displays", "derived", - "solution", - "three", - "septic", - "form", + "interact", + "outer", + "end", + "may", + "resembling", + "15", + "suggesting", + "along", + "vg13p", + "val1", + "compact", + "allowing", + "bacteria", + "peptide", + "forming", + "property", "shock", + "lys", + "responsible", + "enhanced", "compared", - "role", - "vg16krkp", + "another", + "reorients", + "16", + "lps", "properties", - "parent", - "unchanged", + "fold", + "addition", "monocytic", - "another", + "also", + "evident", + "cell", + "14", + "pathogens", + "improved", + "fungal", + "solution", + "interaction", + "strengthened", "reveals", - "via", + "levels", + "hub", "antimicrobial", - "report", - "displays", - "may", - "sepsis", - "leu11", - "closely", - "region", - "activity", - "fungal", - "bacteria", - "observed", - "comparison", - "chair", - "uninterrupted", - "followed", - "gly4", - "hydrophobic", - "responsible", - "property", - "truncation", + "unique", + "mutation", + "designed", + "form", + "central", + "consecutive", + "reduction", "phe12", - "retains", - "compact", - "reorients", - "lys", - "bacterial", "one", - "line", + "way", + "septic", + "observed", + "structure", + "report", "vargwgrkcplfg", - "ala2", - "also", - "study", "flexible", - "along", - "way", - "fold", - "pathogens", - "together", - "evident", - "last", - "well", - "hub", - "vargwkrkcplfgkgg", - "residues", - "two", + "closely", + "followed", + "membrane", "bring", - "vg13p", - "addition", - "central", - "significant", - "15", - "levels", - "end", - "component", - "unhindered", - "major", - "binding", - "val1" + "remained", + "activity", + "expression", + "turn", + "sepsis", + "back", + "comparison", + "significant" ], "release_date":"2017-05-10", "publication":"\"Structural and Dynamic Insights into a Glycine-Mediated Short Analogue of a Designed Peptide in Lipopolysaccharide Micelles: Correlation Between Compact Structure and Anti-Endotoxin Activity\", Biochemistry, 56, 1348-1362", @@ -226055,7 +226625,7 @@ ], "seq_max_sim_designed":{ "sim":33.0, - "partner":"2n65" + "partner":"2n63" }, "seq_max_sim_natural":[ @@ -226139,92 +226709,92 @@ ], "subtitle":"Crystal structure of mitsuba-1 with bound nacgal", "tags":[ - "de novo protein", "sugar binding protein", + "de novo protein", "protein design", "lectin" ], "keywords":[ - "medical", + "treatments", + "repeats", + "glc", + "globotriose", + "crystallised", + "intention", + "three", + "subunit", + "rapidly", + "new", + "model", + "protein", + "study", + "binding", + "site", + "shellfish", + "cells", + "recognises", + "forms", + "motifs", "confirm", + "applications", + "mitsuba", + "lymphoma", + "subdomains", + "japanese", + "dimer", + "gal\u03b1", + "family", + "finding", "matches", - "describes", - "expressed", - "designed", - "member", - "uses", - "contains", - "based", + "last", "basis", "bind", - "structure", - "gal\u03b2", - "novel", - "direct", - "called", "proteins", - "remain", - "unique", - "lectin", - "family", - "rapidly", - "advanced", - "resulting", + "member", + "tandem", + "contains", "small", - "decade", - "lymphoma", - "cytotoxicity", - "natural", - "solution", - "three", - "motifs", - "gal\u03b1", "created", - "crystallised", - "abolished", - "recognises", - "intention", - "galactose", - "artificial", - "finding", - "tandem", - "globotriose", - "dimer", + "tight", + "computational", + "cancer", + "direct", + "surface", + "lectin", + "symmetry", "design", - "model", - "mitsuba", "express", - "applications", - "symmetry", - "surface", - "sequence", - "repeats", - "treatments", - "cells", - "cancer", - "burkitt", - "subdomains", - "constraining", + "medical", + "natural", + "called", + "carry", + "gal\u03b2", + "cytotoxicity", + "solution", + "describes", "predicted", - "glc", + "sequence", + "abolished", + "uses", + "identical", + "unique", + "decade", + "designed", "one", - "study", - "tight", - "carry", - "last", - "subunit", - "examples", "meaning", - "binding", - "protein", - "shellfish", - "identical", - "computational", + "expressed", + "based", + "constraining", + "structure", + "resulting", + "burkitt", + "examples", + "artificial", + "remain", + "galactose", "diagnostics", - "site", - "forms", - "japanese", - "new" + "novel", + "advanced" ], "release_date":"2017-07-12", "publication":"\"Computational design of a symmetrical beta-trefoil lectin with cancer cell binding activity\", Sci Rep, 7, 5943-5943", @@ -226267,31 +226837,31 @@ }, { "sim":186.0, - "partner":"8vcs" + "partner":"8vco" }, { "sim":186.0, - "partner":"8vcm" + "partner":"8vcp" }, { "sim":186.0, - "partner":"8vco" + "partner":"8vcq" }, { "sim":186.0, - "partner":"8vcp" + "partner":"8vcu" }, { "sim":186.0, - "partner":"8vcq" + "partner":"8vcs" }, { "sim":186.0, - "partner":"8vcu" + "partner":"8vck" }, { "sim":186.0, - "partner":"8vck" + "partner":"8vcm" }, { "sim":185.0, @@ -226432,69 +227002,69 @@ ], "subtitle":"Deconstructing the salt-bridge network of a computationally designed collagen heterotrimer", "tags":[ + "ion pairs", "heterotrimer", - "collagen", "structural protein", - "ion pairs" + "collagen" ], "keywords":[ - "stability", - "28", - "predictive", - "contributions", - "providing", - "solved", - "intermolecular", - "specificity", - "lack", - "developed", - "oligomerization", - "resolution", - "modulate", - "balance", - "heterotrimers", - "electrostatics", - "information", - "processes", - "used", - "limits", + "simulations", "demonstrates", "cues", - "simulations", - "heterospecific", - "specific", - "collagen", + "mutagenesis", "engineering", - "state", - "energetics", - "exist", - "bonding", - "atomistic", - "based", - "heterospecificity", + "collagen", + "structural", + "specificity", + "resolution", "mechanistic", - "heterotrimer", - "explore", - "model", - "synthetic", - "interactions", + "limits", + "providing", + "used", "structures", "natural", - "essential", - "structure", - "extracellular", - "mechanics", - "types", + "information", + "heterotrimers", + "intermolecular", "matrix", - "assembly", + "mechanics", + "28", "biological", - "affects", - "understanding", - "novel", "pathological", + "extracellular", + "processes", + "electrostatics", + "structure", + "synthetic", + "assembly", + "based", + "specific", + "novel", + "model", + "explore", + "state", + "interactions", + "oligomerization", + "understanding", + "stability", + "heterotrimer", + "energetics", + "essential", + "modulate", + "heterospecific", "hydrogen", - "structural", - "mutagenesis" + "types", + "predictive", + "solved", + "heterospecificity", + "affects", + "developed", + "balance", + "exist", + "atomistic", + "contributions", + "lack", + "bonding" ], "release_date":"2018-06-13", "publication":"\"How electrostatic networks modulate specificity and stability of collagen\", Proc. Natl. Acad. Sci. U.S.A., 115, 6207-6212", @@ -226597,96 +227167,96 @@ ], "subtitle":"Designed protein drafx6", "tags":[ - "de novo protein", - "designed protein" + "designed protein", + "de novo protein" ], "keywords":[ - "domain", - "evolution", - "many", - "thermostability", - "differentiated", - "pattern", - "acid", - "designed", - "substitutions", - "mutations", - "improved", - "experimentally", - "extremely", - "mostly", - "38", - "structure", - "redesign", - "applied", - "able", - "acquire", - "solve", "affinity", + "demonstrates", + "engineering", + "redesign", + "optimized", "thermostable", - "statistical", - "without", + "pattern", + "substitutions", "combining", - "suggesting", - "proteins", - "redesigned", - "de", - "tools", - "interface", - "distribution", - "demonstrates", - "function", - "native", - "revealed", + "acid", + "replacing", + "new", + "protein", + "study", + "abacus", "significantly", + "given", + "confirmed", + "novo", + "reversibly", + "expected", + "total", "effects", + "solve", + "problems", + "rbd", + "able", + "distribution", + "experimentally", + "relative", + "residues", + "level", + "charge", + "functions", "globally", - "powerful", + "extremely", + "proteins", + "interface", + "conventional", + "suggesting", + "evolution", + "computational", + "tools", "obtained", - "reversibly", - "expected", - "amino", - "strong", + "surface", "challenging", - "functions", - "unfolds", - "engineering", - "provides", - "rbd", - "observed", - "replacing", "design", - "context", - "surface", - "sequence", "energy", - "total", - "conventional", - "beneficial", + "context", + "redesigned", + "provides", + "domain", + "unfolds", "excessive", + "amino", + "improved", + "beneficial", + "invert", + "applied", + "sequence", + "differentiated", + "developed", "analyses", - "abacus", - "optimized", - "study", - "novo", - "way", - "problems", + "mostly", + "designed", + "strong", "directed", - "charge", + "revealed", + "many", + "way", + "mutations", + "observed", + "de", + "acquire", + "48", "epistasis", - "confirmed", - "residues", - "invert", - "protein", - "given", + "without", + "structure", + "thermostability", "unreachable", "loss", - "48", - "computational", - "relative", - "developed", - "level", - "new" + "powerful", + "function", + "38", + "native", + "statistical" ], "release_date":"2018-12-05", "publication":"\"De novo sequence redesign of a functional Ras-binding domain globally inverted the surface charge distribution and led to extreme thermostability\", Biotechnol.Bioeng., 118, 2031-2042", @@ -226730,11 +227300,11 @@ }, { "sim":70.0, - "partner":"4g3x" + "partner":"1c1y" }, { "sim":70.0, - "partner":"1c1y" + "partner":"4g3x" }, { "sim":70.0, @@ -226859,94 +227429,94 @@ ], "subtitle":"Design of a short thermo-stable alpha-helix embedded in a macrocycle", "tags":[ - "constrained peptide", "de novo protein", + "constrained peptide", "de novo" ], "keywords":[ - "thermal", - "unfolding", - "stabilizing", - "thus", - "specificity", - "strategy", - "crystallography", - "peptide", - "determination", + "organic", + "key", + "well", + "semirigid", + "side", "roles", - "designed", - "embedding", - "macrocycle", - "miniprotein", - "towards", - "generally", - "interactions", + "free", + "lead", + "within", + "unstable", + "short", + "strategy", + "behaves", + "leaves", + "successfully", + "foldamer", + "helical", + "binding", + "unfolding", + "confirmed", + "entire", + "helices", + "aqueous", + "play", "conformation", - "structure", "however", - "quaternary", - "novel", - "like", + "specificity", + "determination", + "stabilizing", + "thus", + "proteolytic", + "residues", "increases", - "develop", - "unstable", - "chain", - "amide", - "play", - "entire", + "helix", "although", - "leaves", - "ends", - "successfully", - "short", - "lead", - "includes", - "portion", - "solution", - "semirigid", - "revealed", "transition", - "free", - "solvent", + "quaternary", + "thermal", "stability", - "proteolytic", - "template", - "organic", - "degradation", - "stabilize", - "design", - "helical", - "exposure", - "cooperative", - "nmr", - "foldamer", - "stabilized", - "key", - "introducing", - "groups", - "aqueous", - "helices", "approach", - "also", + "develop", + "generally", + "includes", "unprecedented", + "stabilize", + "like", + "peptide", + "design", "length", - "peptides", - "well", - "confirmed", - "residues", - "fraying", + "chain", "absence", + "amide", + "also", + "groups", + "template", + "potency", + "ends", + "solution", "leading", - "crosslinks", - "central", + "degradation", + "peptides", "implications", + "cooperative", + "designed", "partners", - "helix", - "potency", - "within", - "behaves", - "side", - "binding" + "central", + "fraying", + "introducing", + "revealed", + "portion", + "exposure", + "structure", + "crystallography", + "nmr", + "interactions", + "embedding", + "crosslinks", + "macrocycle", + "towards", + "solvent", + "miniprotein", + "stabilized", + "novel" ], "release_date":"2018-02-21", "publication":"\"Design of a Short Thermally Stable alpha-Helix Embedded in a Macrocycle\", Chembiochem, 19, 902-906", @@ -227052,72 +227622,72 @@ ], "subtitle":"Structure of d-leu-d-phe-2-abz-d-ala at 0.64 angstrom", "tags":[ - "unnatural amino acid", - "peptidomimetic beta-turn", - "tetrapeptide", "d-amino acid", - "de novo protein" + "de novo protein", + "tetrapeptide", + "unnatural amino acid", + "peptidomimetic beta-turn" ], "keywords":[ + "ctp", + "conformation", + "often", + "h", + "analogue", + "adopt", + "compared", + "planar", + "cyclize", + "single", + "agreement", "enabling", + "first", + "3", "distinctly", - "containing", - "synthetically", - "reported", - "results", - "poor", - "inversion", + "three", + "structure", + "acid", "ctps", - "reveals", - "frameworks", + "report", + "results", + "bonds", "herein", - "ring", - "unique", "also", - "bonds", - "report", - "h", - "single", - "planar", - "linear", + "tetrapeptides", + "ring", + "cyclic", "peptidomimetic", - "acid", + "frameworks", + "nmr", + "adopted", + "evident", + "yield", + "linear", + "4", + "solution", "tetrapeptide", - "peptide", - "cyclize", - "1", - "conversion", + "inversion", + "quantitative", + "2", + "poor", + "hydrogen", + "reported", + "reveals", "inaccessible", - "4", - "evident", - "analogue", + "crystals", + "bond", + "conformations", "near", - "ctp", - "agreement", - "quantitative", "crystal", - "3", - "often", - "tetrapeptides", - "yield", - "bond", - "2", - "adopt", - "conformation", - "nmr", - "solution", - "structure", - "stabilized", - "three", + "unique", + "containing", "corresponding", - "adopted", - "compared", - "first", + "stabilized", + "1", + "peptide", + "conversion", "novel", - "conformations", - "hydrogen", - "cyclic", - "crystals" + "synthetically" ], "release_date":"2017-11-15", "publication":"\"Crystal and NMR Structures of a Peptidomimetic beta-Turn That Provides Facile Synthesis of 13-Membered Cyclic Tetrapeptides\", Chem Asian J, 12, 3195-3202", @@ -227219,73 +227789,73 @@ ], "subtitle":"Structure of cyclic d-leu-n-methyl-d-phe-2-abz-d-ala at 0.76 angstrom", "tags":[ - "unnatural amino acid", - "peptidomimetic beta-turn", - "tetrapeptide", "d-amino acid", "de novo protein", + "tetrapeptide", + "unnatural amino acid", + "peptidomimetic beta-turn", "cyclic peptide" ], "keywords":[ + "ctp", + "conformation", + "often", + "h", + "analogue", + "adopt", + "compared", + "planar", + "cyclize", + "single", + "agreement", "enabling", + "first", + "3", "distinctly", - "containing", - "synthetically", - "reported", - "results", - "poor", - "inversion", + "three", + "structure", + "acid", "ctps", - "reveals", - "frameworks", + "report", + "results", + "bonds", "herein", - "ring", - "unique", "also", - "bonds", - "report", - "h", - "single", - "planar", - "linear", + "tetrapeptides", + "ring", + "cyclic", "peptidomimetic", - "acid", + "frameworks", + "nmr", + "adopted", + "evident", + "yield", + "linear", + "4", + "solution", "tetrapeptide", - "peptide", - "cyclize", - "1", - "conversion", + "inversion", + "quantitative", + "2", + "poor", + "hydrogen", + "reported", + "reveals", "inaccessible", - "4", - "evident", - "analogue", + "crystals", + "bond", + "conformations", "near", - "ctp", - "agreement", - "quantitative", "crystal", - "3", - "often", - "tetrapeptides", - "yield", - "bond", - "2", - "adopt", - "conformation", - "nmr", - "solution", - "structure", - "stabilized", - "three", + "unique", + "containing", "corresponding", - "adopted", - "compared", - "first", + "stabilized", + "1", + "peptide", + "conversion", "novel", - "conformations", - "hydrogen", - "cyclic", - "crystals" + "synthetically" ], "release_date":"2017-11-15", "publication":"\"Crystal and NMR Structures of a Peptidomimetic beta-Turn That Provides Facile Synthesis of 13-Membered Cyclic Tetrapeptides\", Chem Asian J, 12, 3195-3202", @@ -227396,94 +227966,94 @@ ], "subtitle":"Design of a short thermally stable alpha-helix embedded in a macrocycle", "tags":[ - "constrained peptide", "de novo protein", + "constrained peptide", "de novo design" ], "keywords":[ - "thermal", - "unfolding", - "stabilizing", - "thus", - "specificity", - "strategy", - "crystallography", - "peptide", - "determination", + "organic", + "key", + "well", + "semirigid", + "side", "roles", - "designed", - "embedding", - "macrocycle", - "miniprotein", - "towards", - "generally", - "interactions", + "free", + "lead", + "within", + "unstable", + "short", + "strategy", + "behaves", + "leaves", + "successfully", + "foldamer", + "helical", + "binding", + "unfolding", + "confirmed", + "entire", + "helices", + "aqueous", + "play", "conformation", - "structure", "however", - "quaternary", - "novel", - "like", + "specificity", + "determination", + "stabilizing", + "thus", + "proteolytic", + "residues", "increases", - "develop", - "unstable", - "chain", - "amide", - "play", - "entire", + "helix", "although", - "leaves", - "ends", - "successfully", - "short", - "lead", - "includes", - "portion", - "solution", - "semirigid", - "revealed", "transition", - "free", - "solvent", + "quaternary", + "thermal", "stability", - "proteolytic", - "template", - "organic", - "degradation", - "stabilize", - "design", - "helical", - "exposure", - "cooperative", - "nmr", - "foldamer", - "stabilized", - "key", - "introducing", - "groups", - "aqueous", - "helices", "approach", - "also", + "develop", + "generally", + "includes", "unprecedented", + "stabilize", + "like", + "peptide", + "design", "length", - "peptides", - "well", - "confirmed", - "residues", - "fraying", + "chain", "absence", + "amide", + "also", + "groups", + "template", + "potency", + "ends", + "solution", "leading", - "crosslinks", - "central", + "degradation", + "peptides", "implications", + "cooperative", + "designed", "partners", - "helix", - "potency", - "within", - "behaves", - "side", - "binding" + "central", + "fraying", + "introducing", + "revealed", + "portion", + "exposure", + "structure", + "crystallography", + "nmr", + "interactions", + "embedding", + "crosslinks", + "macrocycle", + "towards", + "solvent", + "miniprotein", + "stabilized", + "novel" ], "release_date":"2018-02-21", "publication":"\"Design of a Short Thermally Stable alpha-Helix Embedded in a Macrocycle\", Chembiochem, 19, 902-906", @@ -227626,74 +228196,74 @@ ], "subtitle":"Crystal structure of transmembrane protein tmhc4_r", "tags":[ - "multipass transmembrane protein", - "membrane protein", "helical bundle", + "multipass transmembrane protein", + "de novo design", "helical repeat protein", - "de novo design" + "membrane protein" ], "keywords":[ - "monomers", - "containing", - "plasma", - "unfolding", - "76", - "detergent", - "one", - "eight", - "magnetic", - "results", - "proteins", - "membrane", + "designed", + "mammalian", "models", - "report", - "close", - "oligomerization", - "stable", - "wide", - "challenge", - "tetramers", - "four", - "pave", - "experiments", + "design", + "adopt", + "one", + "indicate", "way", - "designed", - "trimers", - "860", + "transmembrane", + "structures", + "localize", + "dimer", "remains", + "monomers", + "860", "residues", + "plasma", + "structure", + "report", + "results", + "trimers", + "experiments", + "residue", + "new", + "76", "functions", - "dimer", - "region", - "two", - "tweezer", - "215", - "crystal", - "state", "target", - "localize", - "bacteria", - "design", - "regions", - "structures", - "residue", - "homodimers", - "adopt", - "mammalian", + "state", + "magnetic", + "oligomerization", "multispan", + "wide", + "membrane", + "homodimers", + "proteins", "solution", - "structure", - "subunits", - "indicate", - "computational", - "transmembrane", + "unfolding", + "eight", "cytoplasmic", + "pave", + "close", + "tetramers", + "cells", + "detergent", "major", + "regions", + "two", + "subunits", + "region", + "stable", "total", - "cells", + "crystal", + "four", + "challenge", + "containing", + "computational", "funnels", + "215", + "bacteria", "base", - "new" + "tweezer" ], "release_date":"2018-03-14", "publication":"\"Accurate computational design of multipass transmembrane proteins\", Science, 359, 1042-1046", @@ -227734,23 +228304,23 @@ }, { "sim":232.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":232.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":232.0, - "partner":"8cus" + "partner":"8cwz" }, { "sim":119.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":119.0, - "partner":"8cqq" + "partner":"8cqp" }, { "sim":119.0, @@ -227758,27 +228328,27 @@ }, { "sim":119.0, - "partner":"8chy" + "partner":"8cmq" }, { "sim":119.0, - "partner":"8cmq" + "partner":"8bu0" }, { "sim":119.0, - "partner":"8ckr" + "partner":"8cp8" }, { "sim":119.0, - "partner":"8cig" + "partner":"8cqq" }, { "sim":119.0, - "partner":"8cqp" + "partner":"8chy" }, { "sim":119.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":117.0, @@ -227798,11 +228368,11 @@ }, { "sim":94.0, - "partner":"5hrz" + "partner":"6vfj" }, { "sim":94.0, - "partner":"6vfj" + "partner":"5hrz" }, { "sim":94.0, @@ -227822,11 +228392,11 @@ }, { "sim":87.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":87.0, - "partner":"8ump" + "partner":"8umr" } ], "seq_thr_sim_natural":[ @@ -227834,10 +228404,6 @@ "sim":87.0, "partner":"1w3b" }, - { - "sim":73.0, - "partner":"4rg6" - }, { "sim":73.0, "partner":"4rg7" @@ -227848,7 +228414,7 @@ }, { "sim":73.0, - "partner":"5lcw" + "partner":"4rg6" }, { "sim":73.0, @@ -227882,6 +228448,10 @@ "sim":73.0, "partner":"4ui9" }, + { + "sim":73.0, + "partner":"5lcw" + }, { "sim":71.0, "partner":"2q7f" @@ -227922,10 +228492,6 @@ "sim":61.0, "partner":"2c0m" }, - { - "sim":61.0, - "partner":"4kyo" - }, { "sim":61.0, "partner":"3r9a" @@ -227938,6 +228504,10 @@ "sim":61.0, "partner":"4kxk" }, + { + "sim":61.0, + "partner":"4kyo" + }, { "sim":61.0, "partner":"1fch" @@ -228073,74 +228643,74 @@ ], "subtitle":"Crystal structure of transmembrane protein tmhc2_e", "tags":[ - "transmembrane protein", - "membrane protein", - "dimer", "helical bundle", - "de novo design" + "dimer", + "de novo design", + "transmembrane protein", + "membrane protein" ], "keywords":[ - "monomers", - "containing", - "plasma", - "unfolding", - "76", - "detergent", - "one", - "eight", - "magnetic", - "results", - "proteins", - "membrane", + "designed", + "mammalian", "models", - "report", - "close", - "oligomerization", - "stable", - "wide", - "challenge", - "tetramers", - "four", - "pave", - "experiments", + "design", + "adopt", + "one", + "indicate", "way", - "designed", - "trimers", - "860", + "transmembrane", + "structures", + "localize", + "dimer", "remains", + "monomers", + "860", "residues", + "plasma", + "structure", + "report", + "results", + "trimers", + "experiments", + "residue", + "new", + "76", "functions", - "dimer", - "region", - "two", - "tweezer", - "215", - "crystal", - "state", "target", - "localize", - "bacteria", - "design", - "regions", - "structures", - "residue", - "homodimers", - "adopt", - "mammalian", + "state", + "magnetic", + "oligomerization", "multispan", + "wide", + "membrane", + "homodimers", + "proteins", "solution", - "structure", - "subunits", - "indicate", - "computational", - "transmembrane", + "unfolding", + "eight", "cytoplasmic", + "pave", + "close", + "tetramers", + "cells", + "detergent", "major", + "regions", + "two", + "subunits", + "region", + "stable", "total", - "cells", + "crystal", + "four", + "challenge", + "containing", + "computational", "funnels", + "215", + "bacteria", "base", - "new" + "tweezer" ], "release_date":"2018-03-14", "publication":"\"Accurate computational design of multipass transmembrane proteins\", Science, 359, 1042-1046", @@ -228252,9 +228822,9 @@ ], "subtitle":"Structure of the artificial complex alpha-rep\/octarellin v.1 crystallized by counter diffusion in a capillary", "tags":[ - "artificial protein", "de novo protein", - "protein design" + "protein design", + "artificial protein" ], "keywords":[ "description", @@ -228466,107 +229036,107 @@ ], "subtitle":"Solution structure of a phosphate-loop protein", "tags":[ - "phosphate loop", - "ideal fold", "de novo protein", + "phosphate loop", "protein design", + "ideal fold", "grafting" ], "keywords":[ - "analysis", - "confer", - "many", - "results", + "relatively", + "polynucleotides", + "structural", + "additional", + "accordingly", + "repeat", + "key", + "show", + "single", "multiple", - "combined", - "including", - "abundant", - "designed", - "carrying", - "avidly", - "mutations", + "via", + "results", + "protein", + "polymorphism", + "facilitated", + "binding", + "presumed", + "motif", + "terminal", + "essential", "throughout", - "polynucleotide", - "show", - "structure", - "repeat", - "applied", + "novo", + "manner", + "depends", + "ntpase", + "motifs", + "confer", + "stable", + "element", "however", + "phosphate", + "soluble", + "action", + "rna", + "dna", + "overall", + "enabled", + "residues", + "incorporated", + "connected", "quaternary", - "avid", + "primarily", + "polynucleotide", + "combined", + "modifications", "proteins", - "dna", - "putative", - "de", + "bound", + "ancestral", "enzymes", - "modern", - "manner", - "yielded", + "scaffold", "small", - "simple", - "simpler", - "ancestral", - "motif", - "implemented", - "essential", - "function", - "absolutely", - "motifs", - "seeds", - "additional", - "polynucleotides", - "element", - "accordingly", - "primarily", + "carrying", "ntps", - "abolished", + "ntpases", + "computational", + "including", "obtained", - "loops", - "incorporated", - "connected", - "via", - "depends", - "rna", - "oligomerization", - "ntpase", - "placed", "promotes", - "transfer", - "polymorphism", + "mediating", + "simpler", "design", - "action", - "soluble", "context", - "facilitated", - "sequence", - "presumed", - "key", - "structural", - "mediating", - "phylogenetic", - "overall", - "groups", - "novo", - "stable", - "single", - "appears", - "residues", - "phosphate", - "logo", - "modifications", + "loops", + "simple", + "modern", "atp", - "scaffold", - "protein", - "bound", + "groups", "foremost", - "terminal", - "relatively", - "computational", + "oligomerization", + "applied", + "sequence", + "abolished", + "plasticity", + "logo", + "phylogenetic", + "seeds", + "designed", + "analysis", "unlike", - "enabled", - "binding", - "ntpases", - "plasticity" + "many", + "mutations", + "de", + "putative", + "structure", + "placed", + "function", + "implemented", + "yielded", + "avid", + "absolutely", + "appears", + "abundant", + "avidly", + "transfer" ], "release_date":"2018-11-21", "publication":"\"Simple yet functional phosphate-loop proteins\", Proc. Natl. Acad. Sci. U.S.A., 115, E11943-E11950", @@ -228719,107 +229289,107 @@ ], "subtitle":"Solution structure of a phosphate-loop protein", "tags":[ - "phosphate loop", - "ideal fold", "de novo protein", + "phosphate loop", "protein design", + "ideal fold", "grafting" ], "keywords":[ - "analysis", - "confer", - "many", - "results", + "relatively", + "polynucleotides", + "structural", + "additional", + "accordingly", + "repeat", + "key", + "show", + "single", "multiple", - "combined", - "including", - "abundant", - "designed", - "carrying", - "avidly", - "mutations", + "via", + "results", + "protein", + "polymorphism", + "facilitated", + "binding", + "presumed", + "motif", + "terminal", + "essential", "throughout", - "polynucleotide", - "show", - "structure", - "repeat", - "applied", + "novo", + "manner", + "depends", + "ntpase", + "motifs", + "confer", + "stable", + "element", "however", + "phosphate", + "soluble", + "action", + "rna", + "dna", + "overall", + "enabled", + "residues", + "incorporated", + "connected", "quaternary", - "avid", + "primarily", + "polynucleotide", + "combined", + "modifications", "proteins", - "dna", - "putative", - "de", + "bound", + "ancestral", "enzymes", - "modern", - "manner", - "yielded", + "scaffold", "small", - "simple", - "simpler", - "ancestral", - "motif", - "implemented", - "essential", - "function", - "absolutely", - "motifs", - "seeds", - "additional", - "polynucleotides", - "element", - "accordingly", - "primarily", + "carrying", "ntps", - "abolished", + "ntpases", + "computational", + "including", "obtained", - "loops", - "incorporated", - "connected", - "via", - "depends", - "rna", - "oligomerization", - "ntpase", - "placed", "promotes", - "transfer", - "polymorphism", + "mediating", + "simpler", "design", - "action", - "soluble", "context", - "facilitated", - "sequence", - "presumed", - "key", - "structural", - "mediating", - "phylogenetic", - "overall", - "groups", - "novo", - "stable", - "single", - "appears", - "residues", - "phosphate", - "logo", - "modifications", + "loops", + "simple", + "modern", "atp", - "scaffold", - "protein", - "bound", + "groups", "foremost", - "terminal", - "relatively", - "computational", + "oligomerization", + "applied", + "sequence", + "abolished", + "plasticity", + "logo", + "phylogenetic", + "seeds", + "designed", + "analysis", "unlike", - "enabled", - "binding", - "ntpases", - "plasticity" + "many", + "mutations", + "de", + "putative", + "structure", + "placed", + "function", + "implemented", + "yielded", + "avid", + "absolutely", + "appears", + "abundant", + "avidly", + "transfer" ], "release_date":"2018-11-21", "publication":"\"Simple yet functional phosphate-loop proteins\", Proc. Natl. Acad. Sci. U.S.A., 115, E11943-E11950", @@ -228956,84 +229526,84 @@ ], "subtitle":"Cross-alpha amyloid-like structure alphaammem", "tags":[ - "cross-alpha amyloid", "de novo protein", - "protein design" + "protein design", + "cross-alpha amyloid" ], "keywords":[ - "spacing", - "versions", - "composed", - "running", - "fibril", + "spiraling", + "designed", + "form", + "superhelical", + "leucine", + "dimers", + "fluorescently", "toxic", - "predetermined", - "long", + "mammalian", + "polymer", + "adopt", "critical", - "170", - "assemblies", - "resulted", + "structural", + "vivo", + "planar", + "running", + "resemble", + "observed", + "structures", + "spacing", "ranging", - "\u00e5", "apolar", - "crystallographically", - "peptide", - "fibrils", - "200", - "peptides", - "designed", - "spiraling", - "twisted", + "different", + "\u00e5", + "amyloids", + "assembly", + "residues", + "structure", + "appeared", + "markedly", "rearrangement", "tagged", + "residue", + "puncta", + "170", + "recently", + "recover", + "protein", + "useful", + "axis", + "200", + "helical", "kinetics", + "packing", + "fibrils", + "solution", "pitches", - "small", - "residues", - "different", - "polymer", - "proposed", - "useful", + "crystallographically", + "resulted", + "photobleaching", + "cells", "directing", + "versions", + "small", + "peptides", + "composed", "potentially", - "characterize", - "photobleaching", - "dimers", - "crystal", - "leucine", + "fibril", "folds", - "amyloids", - "assemble", - "observed", - "fluorescently", - "helical", - "structures", - "superhelical", - "perpendicular", - "residue", - "adopt", "converted", - "puncta", - "mammalian", - "protein", - "stabilities", - "markedly", - "solution", - "structure", - "assembly", + "crystal", + "perpendicular", + "predetermined", + "assemble", + "assemblies", + "long", + "proposed", + "twisted", "stabilized", - "recently", + "characterize", + "peptide", "could", - "vivo", - "form", - "resemble", - "recover", - "axis", - "cells", - "appeared", - "packing", - "structural", - "planar" + "stabilities" ], "release_date":"2018-08-15", "publication":"\"Designed peptides that assemble into cross-alpha amyloid-like structures\", Nat. Chem. Biol., 14, 870-875", @@ -229177,84 +229747,84 @@ ], "subtitle":"Cross-alpha amyloid-like structure alphaamg", "tags":[ - "cross-alpha amyloid", "de novo protein", - "protein design" + "protein design", + "cross-alpha amyloid" ], "keywords":[ - "spacing", - "versions", - "composed", - "running", - "fibril", + "spiraling", + "designed", + "form", + "superhelical", + "leucine", + "dimers", + "fluorescently", "toxic", - "predetermined", - "long", + "mammalian", + "polymer", + "adopt", "critical", - "170", - "assemblies", - "resulted", + "structural", + "vivo", + "planar", + "running", + "resemble", + "observed", + "structures", + "spacing", "ranging", - "\u00e5", "apolar", - "crystallographically", - "peptide", - "fibrils", - "200", - "peptides", - "designed", - "spiraling", - "twisted", + "different", + "\u00e5", + "amyloids", + "assembly", + "residues", + "structure", + "appeared", + "markedly", "rearrangement", "tagged", + "residue", + "puncta", + "170", + "recently", + "recover", + "protein", + "useful", + "axis", + "200", + "helical", "kinetics", + "packing", + "fibrils", + "solution", "pitches", - "small", - "residues", - "different", - "polymer", - "proposed", - "useful", + "crystallographically", + "resulted", + "photobleaching", + "cells", "directing", + "versions", + "small", + "peptides", + "composed", "potentially", - "characterize", - "photobleaching", - "dimers", - "crystal", - "leucine", + "fibril", "folds", - "amyloids", - "assemble", - "observed", - "fluorescently", - "helical", - "structures", - "superhelical", - "perpendicular", - "residue", - "adopt", "converted", - "puncta", - "mammalian", - "protein", - "stabilities", - "markedly", - "solution", - "structure", - "assembly", + "crystal", + "perpendicular", + "predetermined", + "assemble", + "assemblies", + "long", + "proposed", + "twisted", "stabilized", - "recently", + "characterize", + "peptide", "could", - "vivo", - "form", - "resemble", - "recover", - "axis", - "cells", - "appeared", - "packing", - "structural", - "planar" + "stabilities" ], "release_date":"2018-08-15", "publication":"\"Designed peptides that assemble into cross-alpha amyloid-like structures\", Nat. Chem. Biol., 14, 870-875", @@ -229401,84 +229971,84 @@ ], "subtitle":"Cross-alpha amyloid-like structure alphaamg - low resolution", "tags":[ - "cross-alpha amyloid", "de novo protein", - "protein design" + "protein design", + "cross-alpha amyloid" ], "keywords":[ - "spacing", - "versions", - "composed", - "running", - "fibril", + "spiraling", + "designed", + "form", + "superhelical", + "leucine", + "dimers", + "fluorescently", "toxic", - "predetermined", - "long", + "mammalian", + "polymer", + "adopt", "critical", - "170", - "assemblies", - "resulted", + "structural", + "vivo", + "planar", + "running", + "resemble", + "observed", + "structures", + "spacing", "ranging", - "\u00e5", "apolar", - "crystallographically", - "peptide", - "fibrils", - "200", - "peptides", - "designed", - "spiraling", - "twisted", + "different", + "\u00e5", + "amyloids", + "assembly", + "residues", + "structure", + "appeared", + "markedly", "rearrangement", "tagged", + "residue", + "puncta", + "170", + "recently", + "recover", + "protein", + "useful", + "axis", + "200", + "helical", "kinetics", + "packing", + "fibrils", + "solution", "pitches", - "small", - "residues", - "different", - "polymer", - "proposed", - "useful", + "crystallographically", + "resulted", + "photobleaching", + "cells", "directing", + "versions", + "small", + "peptides", + "composed", "potentially", - "characterize", - "photobleaching", - "dimers", - "crystal", - "leucine", + "fibril", "folds", - "amyloids", - "assemble", - "observed", - "fluorescently", - "helical", - "structures", - "superhelical", - "perpendicular", - "residue", - "adopt", "converted", - "puncta", - "mammalian", - "protein", - "stabilities", - "markedly", - "solution", - "structure", - "assembly", + "crystal", + "perpendicular", + "predetermined", + "assemble", + "assemblies", + "long", + "proposed", + "twisted", "stabilized", - "recently", + "characterize", + "peptide", "could", - "vivo", - "form", - "resemble", - "recover", - "axis", - "cells", - "appeared", - "packing", - "structural", - "planar" + "stabilities" ], "release_date":"2018-08-15", "publication":"\"Designed peptides that assemble into cross-alpha amyloid-like structures\", Nat. Chem. Biol., 14, 870-875", @@ -229625,84 +230195,84 @@ ], "subtitle":"Cross-alpha amyloid-like structure alphaams", "tags":[ - "cross-alpha amyloid", "de novo protein", - "protein design" + "protein design", + "cross-alpha amyloid" ], "keywords":[ - "spacing", - "versions", - "composed", - "running", - "fibril", + "spiraling", + "designed", + "form", + "superhelical", + "leucine", + "dimers", + "fluorescently", "toxic", - "predetermined", - "long", + "mammalian", + "polymer", + "adopt", "critical", - "170", - "assemblies", - "resulted", + "structural", + "vivo", + "planar", + "running", + "resemble", + "observed", + "structures", + "spacing", "ranging", - "\u00e5", "apolar", - "crystallographically", - "peptide", - "fibrils", - "200", - "peptides", - "designed", - "spiraling", - "twisted", + "different", + "\u00e5", + "amyloids", + "assembly", + "residues", + "structure", + "appeared", + "markedly", "rearrangement", "tagged", + "residue", + "puncta", + "170", + "recently", + "recover", + "protein", + "useful", + "axis", + "200", + "helical", "kinetics", + "packing", + "fibrils", + "solution", "pitches", - "small", - "residues", - "different", - "polymer", - "proposed", - "useful", + "crystallographically", + "resulted", + "photobleaching", + "cells", "directing", + "versions", + "small", + "peptides", + "composed", "potentially", - "characterize", - "photobleaching", - "dimers", - "crystal", - "leucine", + "fibril", "folds", - "amyloids", - "assemble", - "observed", - "fluorescently", - "helical", - "structures", - "superhelical", - "perpendicular", - "residue", - "adopt", "converted", - "puncta", - "mammalian", - "protein", - "stabilities", - "markedly", - "solution", - "structure", - "assembly", + "crystal", + "perpendicular", + "predetermined", + "assemble", + "assemblies", + "long", + "proposed", + "twisted", "stabilized", - "recently", + "characterize", + "peptide", "could", - "vivo", - "form", - "resemble", - "recover", - "axis", - "cells", - "appeared", - "packing", - "structural", - "planar" + "stabilities" ], "release_date":"2018-08-15", "publication":"\"Designed peptides that assemble into cross-alpha amyloid-like structures\", Nat. Chem. Biol., 14, 870-875", @@ -229822,84 +230392,84 @@ ], "subtitle":"Cross-alpha amyloid-like structure alphaaml", "tags":[ - "cross-alpha amyloid", "de novo protein", - "protein design" + "protein design", + "cross-alpha amyloid" ], "keywords":[ - "spacing", - "versions", - "composed", - "running", - "fibril", + "spiraling", + "designed", + "form", + "superhelical", + "leucine", + "dimers", + "fluorescently", "toxic", - "predetermined", - "long", + "mammalian", + "polymer", + "adopt", "critical", - "170", - "assemblies", - "resulted", + "structural", + "vivo", + "planar", + "running", + "resemble", + "observed", + "structures", + "spacing", "ranging", - "\u00e5", "apolar", - "crystallographically", - "peptide", - "fibrils", - "200", - "peptides", - "designed", - "spiraling", - "twisted", + "different", + "\u00e5", + "amyloids", + "assembly", + "residues", + "structure", + "appeared", + "markedly", "rearrangement", "tagged", + "residue", + "puncta", + "170", + "recently", + "recover", + "protein", + "useful", + "axis", + "200", + "helical", "kinetics", + "packing", + "fibrils", + "solution", "pitches", - "small", - "residues", - "different", - "polymer", - "proposed", - "useful", + "crystallographically", + "resulted", + "photobleaching", + "cells", "directing", + "versions", + "small", + "peptides", + "composed", "potentially", - "characterize", - "photobleaching", - "dimers", - "crystal", - "leucine", + "fibril", "folds", - "amyloids", - "assemble", - "observed", - "fluorescently", - "helical", - "structures", - "superhelical", - "perpendicular", - "residue", - "adopt", "converted", - "puncta", - "mammalian", - "protein", - "stabilities", - "markedly", - "solution", - "structure", - "assembly", + "crystal", + "perpendicular", + "predetermined", + "assemble", + "assemblies", + "long", + "proposed", + "twisted", "stabilized", - "recently", + "characterize", + "peptide", "could", - "vivo", - "form", - "resemble", - "recover", - "axis", - "cells", - "appeared", - "packing", - "structural", - "planar" + "stabilities" ], "release_date":"2018-08-15", "publication":"\"Designed peptides that assemble into cross-alpha amyloid-like structures\", Nat. Chem. Biol., 14, 870-875", @@ -229940,6 +230510,10 @@ "sim":0.9944000244, "partner":"6d02" }, + { + "sim":0.9937000275, + "partner":"6o3n" + }, { "sim":1.0, "partner":"6c4y" @@ -229955,10 +230529,6 @@ { "sim":0.9724000096, "partner":"6c4x" - }, - { - "sim":0.9937000275, - "partner":"6o3n" } ], "struct_thr_sim_natural":[ @@ -230042,84 +230612,84 @@ ], "subtitle":"Cross-alpha amyloid-like structure alphatet", "tags":[ - "cross-alpha amyloid", "de novo protein", - "protein design" + "protein design", + "cross-alpha amyloid" ], "keywords":[ - "spacing", - "versions", - "composed", - "running", - "fibril", + "spiraling", + "designed", + "form", + "superhelical", + "leucine", + "dimers", + "fluorescently", "toxic", - "predetermined", - "long", + "mammalian", + "polymer", + "adopt", "critical", - "170", - "assemblies", - "resulted", + "structural", + "vivo", + "planar", + "running", + "resemble", + "observed", + "structures", + "spacing", "ranging", - "\u00e5", "apolar", - "crystallographically", - "peptide", - "fibrils", - "200", - "peptides", - "designed", - "spiraling", - "twisted", + "different", + "\u00e5", + "amyloids", + "assembly", + "residues", + "structure", + "appeared", + "markedly", "rearrangement", "tagged", + "residue", + "puncta", + "170", + "recently", + "recover", + "protein", + "useful", + "axis", + "200", + "helical", "kinetics", + "packing", + "fibrils", + "solution", "pitches", - "small", - "residues", - "different", - "polymer", - "proposed", - "useful", + "crystallographically", + "resulted", + "photobleaching", + "cells", "directing", + "versions", + "small", + "peptides", + "composed", "potentially", - "characterize", - "photobleaching", - "dimers", - "crystal", - "leucine", + "fibril", "folds", - "amyloids", - "assemble", - "observed", - "fluorescently", - "helical", - "structures", - "superhelical", - "perpendicular", - "residue", - "adopt", "converted", - "puncta", - "mammalian", - "protein", - "stabilities", - "markedly", - "solution", - "structure", - "assembly", + "crystal", + "perpendicular", + "predetermined", + "assemble", + "assemblies", + "long", + "proposed", + "twisted", "stabilized", - "recently", + "characterize", + "peptide", "could", - "vivo", - "form", - "resemble", - "recover", - "axis", - "cells", - "appeared", - "packing", - "structural", - "planar" + "stabilities" ], "release_date":"2018-08-15", "publication":"\"Designed peptides that assemble into cross-alpha amyloid-like structures\", Nat. Chem. Biol., 14, 870-875", @@ -230250,111 +230820,111 @@ ], "subtitle":"Single-particle reconstruction of darp14 - a designed protein scaffold displaying ~17kda darpin proteins", "tags":[ - "scaffold", - "designed complex", "single-particle cryo-em", + "designed complex", + "darpin", "de novo protein", - "darpin" + "scaffold" ], "keywords":[ - "analysis", - "confer", - "us", - "use", + "elucidation", + "demonstrates", + "structural", + "resolution", + "show", + "amenable", "complexes", - "attached", - "imaging", + "clearly", + "presently", + "macromolecules", + "subunit", "route", - "chosen", - "linker", "acid", - "allowing", - "scaffolding", - "designed", - "current", + "arrayed", + "make", + "symmetrical", + "various", + "protein", + "helical", + "binding", + "continuous", + "microscopy", + "connect", "throughout", "potentially", - "smaller", + "confer", "crystal", - "show", - "typical", - "structure", - "alpha", - "however", + "growth", + "using", + "broadening", + "attached", "solve", - "fashion", - "amenable", - "limit", - "elucidation", - "without", + "however", + "linker", + "us", + "furthermore", + "macromolecular", + "50", + "rigid", + "level", "visualized", - "detail", - "proteins", - "growth", - "cell", - "produce", "images", - "kda", - "resulting", + "large", + "proteins", + "size", + "use", + "modular", + "scaffold", + "cage", "small", - "demonstrates", - "rigid", - "symmetric", - "furthermore", - "symmetrical", - "macromolecular", - "atomic", - "construct", - "theoretical", - "suitable", + "found", "future", - "size", - "cubic", - "molecules", + "construct", + "tight", + "allowing", "need", - "broadening", + "symmetry", + "design", + "theoretical", + "atomic", + "diverse", + "current", + "provides", + "produce", + "application", + "chosen", + "nucleic", + "cell", "amino", - "large", - "cage", + "kda", + "alpha", + "limit", + "symmetric", + "sequence", + "system", + "considerably", + "techniques", "assemblies", + "designed", + "analysis", + "suitable", "ranging", "detailed", - "resolution", - "continuous", + "imaging", + "darpin", + "without", + "structure", + "resulting", + "typical", + "detail", + "molecules", + "fashion", "identify", - "presently", - "connect", + "smaller", "result", - "provides", - "application", - "design", - "helical", - "considerably", - "using", - "symmetry", - "sequence", - "techniques", - "clearly", - "arrayed", - "structural", - "diverse", - "make", - "nucleic", - "tight", - "modular", - "darpin", - "found", - "subunit", - "system", - "50", - "scaffold", - "macromolecules", - "protein", - "microscopy", - "various", - "binding", - "create", - "level" + "scaffolding", + "cubic", + "create" ], "release_date":"2018-03-21", "publication":"\"Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system\", Proc. Natl. Acad. Sci. U.S.A., 115, 3362-3367", @@ -230427,19 +230997,19 @@ }, { "sim":261.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":261.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":261.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":261.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":261.0, @@ -230447,35 +231017,35 @@ }, { "sim":261.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":261.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":261.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":261.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":261.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":261.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":261.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":261.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":260.0, @@ -230507,11 +231077,11 @@ }, { "sim":256.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":256.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":253.0, @@ -230619,7 +231189,7 @@ }, { "sim":224.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":224.0, @@ -230627,7 +231197,7 @@ }, { "sim":224.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":223.0, @@ -230651,11 +231221,11 @@ }, { "sim":221.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":221.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":221.0, @@ -230683,11 +231253,11 @@ }, { "sim":196.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":196.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":194.0, @@ -230727,11 +231297,11 @@ }, { "sim":177.0, - "partner":"5kba" + "partner":"5hry" }, { "sim":177.0, - "partner":"5hry" + "partner":"5kba" }, { "sim":173.0, @@ -230745,6 +231315,10 @@ "sim":173.0, "partner":"5eil" }, + { + "sim":171.0, + "partner":"9glq" + }, { "sim":166.0, "partner":"5hs0" @@ -230859,10 +231433,6 @@ "sim":260.0, "partner":"2bkk" }, - { - "sim":259.0, - "partner":"5eno" - }, { "sim":259.0, "partner":"4dx6" @@ -230935,6 +231505,10 @@ "sim":259.0, "partner":"4dx5" }, + { + "sim":259.0, + "partner":"5eno" + }, { "sim":258.0, "partner":"4hrl" @@ -230977,11 +231551,11 @@ }, { "sim":250.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":250.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":250.0, @@ -231057,11 +231631,11 @@ }, { "sim":232.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":232.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":231.0, @@ -231073,11 +231647,11 @@ }, { "sim":224.0, - "partner":"4jb8" + "partner":"5mbm" }, { "sim":224.0, - "partner":"5mbm" + "partner":"4jb8" }, { "sim":218.0, @@ -231215,10 +231789,6 @@ "sim":114.0, "partner":"2l6b" }, - { - "sim":110.0, - "partner":"5vhj" - }, { "sim":110.0, "partner":"5vhh" @@ -231247,6 +231817,10 @@ "sim":110.0, "partner":"5vho" }, + { + "sim":110.0, + "partner":"5vhj" + }, { "sim":110.0, "partner":"5vhp" @@ -231273,15 +231847,15 @@ }, { "sim":109.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":109.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":109.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":109.0, @@ -231393,11 +231967,11 @@ }, { "sim":95.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":95.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":95.0, @@ -231473,11 +232047,11 @@ }, { "sim":89.0, - "partner":"2r6x" + "partner":"3gah" }, { "sim":89.0, - "partner":"3gah" + "partner":"2r6x" }, { "sim":88.0, @@ -231661,11 +232235,11 @@ }, { "sim":78.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":78.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":77.0, @@ -231703,10 +232277,6 @@ "sim":76.0, "partner":"5wo6" }, - { - "sim":76.0, - "partner":"5iwr" - }, { "sim":76.0, "partner":"5iwt" @@ -231735,6 +232305,10 @@ "sim":76.0, "partner":"5iwp" }, + { + "sim":76.0, + "partner":"5iwr" + }, { "sim":76.0, "partner":"5wo7" @@ -231781,15 +232355,15 @@ }, { "sim":71.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":71.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":71.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":70.0, @@ -231865,15 +232439,15 @@ }, { "sim":64.0, - "partner":"6bo9" + "partner":"6boa" }, { "sim":64.0, - "partner":"6boa" + "partner":"6bo8" }, { "sim":64.0, - "partner":"6bo8" + "partner":"6bo9" }, { "sim":63.0, @@ -232139,104 +232713,104 @@ ], "subtitle":"Structure of a redesigned beta barrel, b11l5f_lgl", "tags":[ - "computational", - "ligand binding", - "de novo protein", "de novo", "rossetta", + "de novo protein", + "computational", + "ligand binding", "beta barrel" ], "keywords":[ - "parametric", "surrounding", - "available", - "use", - "compound", - "date", - "catalysts", - "search", - "geometries", - "requires", - "shapes", - "irregular", + "escherichia", + "complementarity", + "yeast", "limited", + "cavities", + "structural", "show", - "increasingly", + "cavity", + "around", + "simultaneously", + "protein", + "globular", + "accurate", + "vitro", + "binding", + "continuous", + "sophisticated", + "novo", + "cells", + "match", + "parametric", + "dfhbi", + "using", + "placement", + "tertiary", + "achieve", "fluorescently", - "bind", - "optimize", - "escherichia", - "axis", + "compound", "backbones", - "achieve", - "dfhbi", - "fascinated", - "coiled", - "hierarchical", + "fluorogenic", + "ligand", + "discovered", + "axis", + "bind", "proteins", - "models", - "de", + "accuracy", + "use", + "success", + "shapes", + "available", + "chemical", + "since", + "coils", + "identities", + "catalysts", + "fascinated", + "geometries", + "activate", + "mammalian", + "design", "strain", + "ensembles", "used", "simple", - "vitro", - "sensors", - "match", - "cavity", - "structures", - "mammalian", - "coils", - "tertiary", - "first", - "simultaneously", - "discovered", - "activate", - "considerable", + "build", "amino", - "complementarity", - "chemical", + "wide", + "backbone", + "contrast", "coli", - "globular", - "continuous", - "eliminate", - "accurate", - "method", - "acids", - "shape", - "activity", "biologists", - "design", + "requires", "connectivity", - "using", - "high", - "cavities", - "cells", - "known", - "around", - "structural", - "identities", - "accuracy", "range", - "sophisticated", - "designs", - "ligand", - "build", - "placement", - "wide", - "success", - "novo", - "contrast", - "enable", - "arrangements", - "fluorogenic", + "method", + "optimize", "central", - "protein", + "search", + "models", + "eliminate", + "structures", + "de", + "first", + "hierarchical", + "shape", + "irregular", + "known", "regular", - "backbone", - "ensembles", - "yeast", - "binding", - "since" + "enable", + "coiled", + "considerable", + "high", + "activity", + "date", + "acids", + "increasingly", + "sensors", + "arrangements", + "designs" ], "release_date":"2018-09-19", "publication":"\"De novo design of a fluorescence-activating beta-barrel\", Nature, 561, 485-491", @@ -232417,104 +232991,104 @@ ], "subtitle":"Structure of a redesigned beta barrel, mfap0, bound to dfhbi", "tags":[ - "computational", - "de novo protein", "ligand binder", "de novo", "rossetta", + "de novo protein", + "computational", "beta barrel" ], "keywords":[ - "parametric", "surrounding", - "available", - "use", - "compound", - "date", - "catalysts", - "search", - "geometries", - "requires", - "shapes", - "irregular", + "escherichia", + "complementarity", + "yeast", "limited", + "cavities", + "structural", "show", - "increasingly", + "cavity", + "around", + "simultaneously", + "protein", + "globular", + "accurate", + "vitro", + "binding", + "continuous", + "sophisticated", + "novo", + "cells", + "match", + "parametric", + "dfhbi", + "using", + "placement", + "tertiary", + "achieve", "fluorescently", - "bind", - "optimize", - "escherichia", - "axis", + "compound", "backbones", - "achieve", - "dfhbi", - "fascinated", - "coiled", - "hierarchical", + "fluorogenic", + "ligand", + "discovered", + "axis", + "bind", "proteins", - "models", - "de", + "accuracy", + "use", + "success", + "shapes", + "available", + "chemical", + "since", + "coils", + "identities", + "catalysts", + "fascinated", + "geometries", + "activate", + "mammalian", + "design", "strain", + "ensembles", "used", "simple", - "vitro", - "sensors", - "match", - "cavity", - "structures", - "mammalian", - "coils", - "tertiary", - "first", - "simultaneously", - "discovered", - "activate", - "considerable", + "build", "amino", - "complementarity", - "chemical", + "wide", + "backbone", + "contrast", "coli", - "globular", - "continuous", - "eliminate", - "accurate", - "method", - "acids", - "shape", - "activity", "biologists", - "design", + "requires", "connectivity", - "using", - "high", - "cavities", - "cells", - "known", - "around", - "structural", - "identities", - "accuracy", "range", - "sophisticated", - "designs", - "ligand", - "build", - "placement", - "wide", - "success", - "novo", - "contrast", - "enable", - "arrangements", - "fluorogenic", + "method", + "optimize", "central", - "protein", + "search", + "models", + "eliminate", + "structures", + "de", + "first", + "hierarchical", + "shape", + "irregular", + "known", "regular", - "backbone", - "ensembles", - "yeast", - "binding", - "since" + "enable", + "coiled", + "considerable", + "high", + "activity", + "date", + "acids", + "increasingly", + "sensors", + "arrangements", + "designs" ], "release_date":"2018-09-19", "publication":"\"De novo design of a fluorescence-activating beta-barrel\", Nature, 561, 485-491", @@ -232691,103 +233265,103 @@ ], "subtitle":"Structure of a redesigned beta barrel, mfap1, bound to dfhbi", "tags":[ - "computational", - "de novo protein", "de novo", "rossetta", + "de novo protein", + "computational", "beta barrel" ], "keywords":[ - "parametric", "surrounding", - "available", - "use", - "compound", - "date", - "catalysts", - "search", - "geometries", - "requires", - "shapes", - "irregular", + "escherichia", + "complementarity", + "yeast", "limited", + "cavities", + "structural", "show", - "increasingly", + "cavity", + "around", + "simultaneously", + "protein", + "globular", + "accurate", + "vitro", + "binding", + "continuous", + "sophisticated", + "novo", + "cells", + "match", + "parametric", + "dfhbi", + "using", + "placement", + "tertiary", + "achieve", "fluorescently", - "bind", - "optimize", - "escherichia", - "axis", + "compound", "backbones", - "achieve", - "dfhbi", - "fascinated", - "coiled", - "hierarchical", + "fluorogenic", + "ligand", + "discovered", + "axis", + "bind", "proteins", - "models", - "de", + "accuracy", + "use", + "success", + "shapes", + "available", + "chemical", + "since", + "coils", + "identities", + "catalysts", + "fascinated", + "geometries", + "activate", + "mammalian", + "design", "strain", + "ensembles", "used", "simple", - "vitro", - "sensors", - "match", - "cavity", - "structures", - "mammalian", - "coils", - "tertiary", - "first", - "simultaneously", - "discovered", - "activate", - "considerable", + "build", "amino", - "complementarity", - "chemical", + "wide", + "backbone", + "contrast", "coli", - "globular", - "continuous", - "eliminate", - "accurate", - "method", - "acids", - "shape", - "activity", "biologists", - "design", + "requires", "connectivity", - "using", - "high", - "cavities", - "cells", - "known", - "around", - "structural", - "identities", - "accuracy", "range", - "sophisticated", - "designs", - "ligand", - "build", - "placement", - "wide", - "success", - "novo", - "contrast", - "enable", - "arrangements", - "fluorogenic", + "method", + "optimize", "central", - "protein", + "search", + "models", + "eliminate", + "structures", + "de", + "first", + "hierarchical", + "shape", + "irregular", + "known", "regular", - "backbone", - "ensembles", - "yeast", - "binding", - "since" + "enable", + "coiled", + "considerable", + "high", + "activity", + "date", + "acids", + "increasingly", + "sensors", + "arrangements", + "designs" ], "release_date":"2018-09-19", "publication":"\"De novo design of a fluorescence-activating beta-barrel\", Nature, 561, 485-491", @@ -232964,103 +233538,103 @@ ], "subtitle":"Structure of a redesigned beta barrel, b10", "tags":[ - "computational", - "de novo protein", "de novo", "rossetta", + "de novo protein", + "computational", "beta barrel" ], "keywords":[ - "parametric", "surrounding", - "available", - "use", - "compound", - "date", - "catalysts", - "search", - "geometries", - "requires", - "shapes", - "irregular", + "escherichia", + "complementarity", + "yeast", "limited", + "cavities", + "structural", "show", - "increasingly", + "cavity", + "around", + "simultaneously", + "protein", + "globular", + "accurate", + "vitro", + "binding", + "continuous", + "sophisticated", + "novo", + "cells", + "match", + "parametric", + "dfhbi", + "using", + "placement", + "tertiary", + "achieve", "fluorescently", - "bind", - "optimize", - "escherichia", - "axis", + "compound", "backbones", - "achieve", - "dfhbi", - "fascinated", - "coiled", - "hierarchical", + "fluorogenic", + "ligand", + "discovered", + "axis", + "bind", "proteins", - "models", - "de", + "accuracy", + "use", + "success", + "shapes", + "available", + "chemical", + "since", + "coils", + "identities", + "catalysts", + "fascinated", + "geometries", + "activate", + "mammalian", + "design", "strain", + "ensembles", "used", "simple", - "vitro", - "sensors", - "match", - "cavity", - "structures", - "mammalian", - "coils", - "tertiary", - "first", - "simultaneously", - "discovered", - "activate", - "considerable", + "build", "amino", - "complementarity", - "chemical", + "wide", + "backbone", + "contrast", "coli", - "globular", - "continuous", - "eliminate", - "accurate", - "method", - "acids", - "shape", - "activity", "biologists", - "design", + "requires", "connectivity", - "using", - "high", - "cavities", - "cells", - "known", - "around", - "structural", - "identities", - "accuracy", "range", - "sophisticated", - "designs", - "ligand", - "build", - "placement", - "wide", - "success", - "novo", - "contrast", - "enable", - "arrangements", - "fluorogenic", + "method", + "optimize", "central", - "protein", + "search", + "models", + "eliminate", + "structures", + "de", + "first", + "hierarchical", + "shape", + "irregular", + "known", "regular", - "backbone", - "ensembles", - "yeast", - "binding", - "since" + "enable", + "coiled", + "considerable", + "high", + "activity", + "date", + "acids", + "increasingly", + "sensors", + "arrangements", + "designs" ], "release_date":"2018-09-19", "publication":"\"De novo design of a fluorescence-activating beta-barrel\", Nature, 561, 485-491", @@ -233205,87 +233779,87 @@ ], "subtitle":"Cross-alpha amyloid-like structure alphaaml, 2nd form", "tags":[ - "coiled-coil", - "fabril", "protein desidn", + "de novo", "de novo protein", + "coiled-coil", "alpha-amyloid", - "de novo" + "fabril" ], "keywords":[ - "spacing", - "versions", - "composed", - "running", - "fibril", + "spiraling", + "designed", + "form", + "superhelical", + "leucine", + "dimers", + "fluorescently", "toxic", - "predetermined", - "long", + "mammalian", + "polymer", + "adopt", "critical", - "170", - "assemblies", - "resulted", + "structural", + "vivo", + "planar", + "running", + "resemble", + "observed", + "structures", + "spacing", "ranging", - "\u00e5", "apolar", - "crystallographically", - "peptide", - "fibrils", - "200", - "peptides", - "designed", - "spiraling", - "twisted", + "different", + "\u00e5", + "amyloids", + "assembly", + "residues", + "structure", + "appeared", + "markedly", "rearrangement", "tagged", + "residue", + "puncta", + "170", + "recently", + "recover", + "protein", + "useful", + "axis", + "200", + "helical", "kinetics", + "packing", + "fibrils", + "solution", "pitches", - "small", - "residues", - "different", - "polymer", - "proposed", - "useful", + "crystallographically", + "resulted", + "photobleaching", + "cells", "directing", + "versions", + "small", + "peptides", + "composed", "potentially", - "characterize", - "photobleaching", - "dimers", - "crystal", - "leucine", + "fibril", "folds", - "amyloids", - "assemble", - "observed", - "fluorescently", - "helical", - "structures", - "superhelical", - "perpendicular", - "residue", - "adopt", "converted", - "puncta", - "mammalian", - "protein", - "stabilities", - "markedly", - "solution", - "structure", - "assembly", + "crystal", + "perpendicular", + "predetermined", + "assemble", + "assemblies", + "long", + "proposed", + "twisted", "stabilized", - "recently", + "characterize", + "peptide", "could", - "vivo", - "form", - "resemble", - "recover", - "axis", - "cells", - "appeared", - "packing", - "structural", - "planar" + "stabilities" ], "release_date":"2019-02-20", "publication":"\"Designed peptides that assemble into cross-alpha amyloid-like structures\", Nat. Chem. Biol., 14, 870-875", @@ -233326,6 +233900,10 @@ "sim":1.0, "partner":"6c51" }, + { + "sim":0.9937999845, + "partner":"6o3n" + }, { "sim":1.0, "partner":"6c4y" @@ -233341,10 +233919,6 @@ { "sim":0.9767000079, "partner":"6c4x" - }, - { - "sim":0.9937999845, - "partner":"6o3n" } ], "struct_thr_sim_natural":[ @@ -233465,100 +234039,100 @@ "subtitle":"De novo design of a fluorescence-activating beta barrel - bb1", "tags":[ "de novo protein", - "design", - "beta-barrel" + "beta-barrel", + "design" ], "keywords":[ - "parametric", "surrounding", - "available", - "use", - "compound", - "date", - "catalysts", - "search", - "geometries", - "requires", - "shapes", - "irregular", + "escherichia", + "complementarity", + "yeast", "limited", + "cavities", + "structural", "show", - "increasingly", + "cavity", + "around", + "simultaneously", + "protein", + "globular", + "accurate", + "vitro", + "binding", + "continuous", + "sophisticated", + "novo", + "cells", + "match", + "parametric", + "dfhbi", + "using", + "placement", + "tertiary", + "achieve", "fluorescently", - "bind", - "optimize", - "escherichia", - "axis", + "compound", "backbones", - "achieve", - "dfhbi", - "fascinated", - "coiled", - "hierarchical", + "fluorogenic", + "ligand", + "discovered", + "axis", + "bind", "proteins", - "models", - "de", + "accuracy", + "use", + "success", + "shapes", + "available", + "chemical", + "since", + "coils", + "identities", + "catalysts", + "fascinated", + "geometries", + "activate", + "mammalian", + "design", "strain", + "ensembles", "used", "simple", - "vitro", - "sensors", - "match", - "cavity", - "structures", - "mammalian", - "coils", - "tertiary", - "first", - "simultaneously", - "discovered", - "activate", - "considerable", + "build", "amino", - "complementarity", - "chemical", + "wide", + "backbone", + "contrast", "coli", - "globular", - "continuous", - "eliminate", - "accurate", - "method", - "acids", - "shape", - "activity", "biologists", - "design", + "requires", "connectivity", - "using", - "high", - "cavities", - "cells", - "known", - "around", - "structural", - "identities", - "accuracy", "range", - "sophisticated", - "designs", - "ligand", - "build", - "placement", - "wide", - "success", - "novo", - "contrast", - "enable", - "arrangements", - "fluorogenic", + "method", + "optimize", "central", - "protein", + "search", + "models", + "eliminate", + "structures", + "de", + "first", + "hierarchical", + "shape", + "irregular", + "known", "regular", - "backbone", - "ensembles", - "yeast", - "binding", - "since" + "enable", + "coiled", + "considerable", + "high", + "activity", + "date", + "acids", + "increasingly", + "sensors", + "arrangements", + "designs" ], "release_date":"2018-09-19", "publication":"\"De novo design of a fluorescence-activating beta-barrel\", Nature, 561, 485-491", @@ -233678,87 +234252,87 @@ ], "subtitle":"Trp-cage tr16b r16nva : elimination of ph dependent interactions", "tags":[ - "circular permutant", - "trp-cage", "de novo protein", "microprotein", - "miniprotein" + "miniprotein", + "circular permutant", + "trp-cage" ], "keywords":[ - "salt", - "spatial", + "surface", + "strong", + "rate", "7", + "dependent", + "additional", + "number", "chain", - "prepared", - "change", - "bridge", + "rather", + "determination", + "efforts", "stabilizing", - "shielding", - "destabilized", - "conditions", - "asp", - "ring", - "prior", - "also", - "study", - "close", - "stable", + "proximity", + "3", + "spatial", + "side", + "prepared", + "species", + "measures", "quantitated", - "evaluating", - "efforts", - "listed", + "remains", + "exposure", + "structure", "fold", - "test", - "determination", - "strong", - "dependence", - "number", "among", - "1", + "within", + "helix", + "provided", + "residue", + "folding", "prediction", - "4", - "species", - "remains", - "miniprotein", - "system", - "3", + "bridge", + "notable", + "also", + "ring", + "interactions", "state", - "ionized", - "rate", + "study", + "shielding", "folded", - "notable", + "ph", + "significantly", "destabilizing", - "interactions", - "residue", - "rather", + "salt", + "4", + "mutants", + "evaluating", + "turns", + "interaction", + "conditions", + "primary", + "close", "2", - "termini", + "change", + "ionized", + "indole", + "test", + "asp", + "system", + "constant", + "destabilized", + "listed", "present", - "exposure", - "surface", - "helix", - "structure", - "proximity", + "stable", "contribution", - "turns", - "constant", - "emerged", - "dependent", - "significantly", - "within", - "computational", + "miniprotein", + "termini", "effects", - "mutants", + "prior", + "computational", + "dependence", + "1", "asp9", - "ph", - "additional", - "primary", - "side", - "measures", - "folding", - "indole", - "provided", - "interaction" + "emerged" ], "release_date":"2019-03-13", "publication":"\"Reversing the typical pH stability profile of the Trp-cage\", Biopolymers, 110, e23260-e23260", @@ -233930,129 +234504,129 @@ "heterodimer" ], "keywords":[ - "hence", - "logic", - "restricted", - "heptad", - "possibilities", - "specificity", + "simply", + "escherichia", + "complementarity", + "number", + "show", "complexes", - "exception", - "close", - "expressed", - "designed", - 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"hence", - "logic", - "restricted", - "heptad", - "possibilities", - "specificity", + "simply", + "escherichia", + "complementarity", + "number", + "show", "complexes", - "exception", - "close", - "expressed", - "designed", - "bases", - "example", + "around", + "side", + "illustrates", "mixing", - "crystal", - "show", - "denaturation", - "interactions", - "synthetic", - "optimize", - "escherichia", + "short", + "accommodating", + "degrees", + "protein", + "six", + "mass", + "5", + "positions", + "across", + "fully", + "connect", + "close", + "extensive", "networks", - "16", - "axis", - "coming", + "confirmed", + "sophisticated", + "cells", + "two", + "crystal", + "helices", + "chains", + "using", + "remainder", "backbones", - "illustrates", - "interaction", - "generating", - "5", - "hydrochloride", - "models", - "biomolecular", - "dna", - "produce", - "less", - "number", - "cognate", + "specificity", + "formed", + "limits", "equations", - "interface", - "used", - "short", - "fully", - 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"hence", - "logic", - "restricted", - "heptad", - "possibilities", - "specificity", + "simply", + "escherichia", + "complementarity", + "number", + "show", "complexes", - "exception", - "close", - "expressed", - "designed", - "bases", - "example", + "around", + "side", + "illustrates", "mixing", - "crystal", - "show", - "denaturation", - "interactions", - "synthetic", - "optimize", - "escherichia", + "short", + "accommodating", + "degrees", + "protein", + "six", + "mass", + "5", + "positions", + "across", + "fully", + "connect", + "close", + "extensive", "networks", - "16", - "axis", - "coming", + "confirmed", + "sophisticated", + "cells", + "two", + "crystal", + "helices", + "chains", + "using", + "remainder", "backbones", - "illustrates", - "interaction", - "generating", - "5", - "hydrochloride", - "models", - "biomolecular", - "dna", - "produce", - "less", - "number", - "cognate", + "specificity", + "formed", + "limits", "equations", - "interface", - "used", - "short", - "fully", - 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"hence", - "logic", - "restricted", - "heptad", - "possibilities", - "specificity", + "simply", + "escherichia", + "complementarity", + "number", + "show", "complexes", - "exception", - "close", - "expressed", - "designed", - "bases", - "example", + "around", + "side", + "illustrates", "mixing", - "crystal", - "show", - "denaturation", - "interactions", - "synthetic", - "optimize", - "escherichia", + "short", + "accommodating", + "degrees", + "protein", + "six", + "mass", + "5", + "positions", + "across", + "fully", + "connect", + "close", + "extensive", "networks", - "16", - "axis", - "coming", + "confirmed", + "sophisticated", + "cells", + "two", + "crystal", + "helices", + "chains", + "using", + "remainder", "backbones", - "illustrates", - "interaction", - "generating", - "5", - "hydrochloride", - "models", - "biomolecular", - "dna", - "produce", - "less", - "number", - "cognate", + "specificity", + "formed", + "limits", "equations", - "interface", - "used", - "short", - "fully", - 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"hence", - "logic", - "restricted", - "heptad", - "possibilities", - "specificity", + "simply", + "escherichia", + "complementarity", + "number", + "show", "complexes", - "exception", - "close", - "expressed", - "designed", - "bases", - "example", + "around", + "side", + "illustrates", "mixing", - "crystal", - "show", - "denaturation", - "interactions", - "synthetic", - "optimize", - "escherichia", + "short", + "accommodating", + "degrees", + "protein", + "six", + "mass", + "5", + "positions", + "across", + "fully", + "connect", + "close", + "extensive", "networks", - "16", - "axis", - "coming", + "confirmed", + "sophisticated", + "cells", + "two", + "crystal", + "helices", + "chains", + "using", + "remainder", "backbones", - "illustrates", - "interaction", - "generating", - "5", - "hydrochloride", - "models", - "biomolecular", - "dna", - "produce", - "less", - "number", - "cognate", + "specificity", + "formed", + "limits", "equations", - "interface", - "used", - "short", - "fully", - 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"might", - "despite", "cysteine", - "one", - "grown", - "blue", "also", - "study", - "cu", - "stable", - "categorized", - "novo", - "cm", - "hyperfine", - "fold", - "spectroscopy", - "different", - "scaffold", - "exact", + "red", "explore", + "absorption", + "interaction", + "series", + "reported", + "solved", + "common", + "demonstrated", + "suggested", + "crystals", + "present", + "ii", + "blue", + "proposed", + "mutation", "prove", - "bound", - "protein", - "previous", - "differences", - "within", + "designed", + "analysis", + "diffraction", + "one", + "histidine", + "u", + "geometry", + "mutations", + "recapitulate", + "constructs", + "de", + "hyperfine", + "first", + "3", + "previously", + "\u00e5", + "structure", + "exact", + "might", + "greek", + "tuning", + "native", "distinct", - "enabled", - "site", - "forms", - "crystals", - "new" + "requisite", + "constant", + "result", + "despite", + "studies", + "quality", + "dchc2", + "green", + "nuclearity" ], "release_date":"2018-10-03", "publication":"\"Clarifying the Copper Coordination Environment in a de Novo Designed Red Copper Protein\", Inorg Chem, 57, 12291-12302", @@ -235933,82 +236507,82 @@ ], "subtitle":"Solution nmr structure of a de novo designed double-stranded beta-helix", "tags":[ - "beta protein", "de novo protein", + "beta protein", "de novo", "beta sheet" ], "keywords":[ - "series", - "hence", + "open", + "antiparallel", + "critical", + "design", "structural", - "control", - "constraints", + "exposed", + "geometry", + "length", + "principles", + "loop", + "owing", + "connecting", "chain", - "despite", - "eight", - "results", + "de", "loops", + "biology", + "structures", + "hence", + "first", + "side", + "lags", + "potential", + "arise", + "identified", + "structure", + "scaffolds", + "results", + "closely", + "functions", + "directionality", + "matched", + "model", + "control", + "protein", + "carry", + "nature", + "study", + "relationships", "magnetic", - "critical", + "tendency", "proteins", "unpaired", - "tendency", - "use", - "geometry", - "study", - "de", - "novo", - "aggregate", - "length", - "behind", - "attractive", - "scaffolds", - "matched", - "door", + "packing", "accurate", - "carry", - "open", - "demonstrating", - "functions", - "closely", + "regular", + "eight", "broad", + "use", + "series", + "novo", + "constraints", + "domains", + "far", + "hydrogen", "jellyroll", - "identified", - "nature", + "resonance", + "despite", + "behind", "nuclear", - "antiparallel", - "lags", - "potential", - "far", - "domains", - "bonding", - "design", - "relationships", - "arise", "hyperthermostable", - "model", - "structures", - "protein", + "attractive", + "aggregate", + "range", + "rules", + "demonstrating", "edges", - "regular", - "connecting", - "structure", - "resonance", - "biology", - "directionality", "computational", - "owing", - "principles", - "side", - "first", - "rules", - "packing", - "hydrogen", - "exposed", + "door", "formed", - "loop", - "range" + "bonding" ], "release_date":"2018-11-07", "publication":"\"De novo design of a non-local beta-sheet protein with high stability and accuracy\", Nat. Struct. Mol. Biol., 25, 1028-1034", @@ -236109,84 +236683,84 @@ "heterogeneous backbone foldamer" ], "keywords":[ - "viable", - "results", - "herein", - "use", - "low", - "designed", - "enjoy", - "sequences", - "synthetic", - "topologically", "adopt", + "constrained", + "structural", + "development", + "collectively", "widespread", - "computationally", - "leads", - "however", - "building", - "exerting", - "chain", - "topology", + "results", + "foldamers", + "new", + "folding", + "various", + "foldamer", + "protein", + "demonstrate", + "systems", + "bioactive", + "indistinguishable", + "substitution", + "exciting", + "tertiary", "enables", - "variants", - "expands", - "beyond", - "constrained", + "however", + "creation", + "mimicry", + "computationally", "oxidative", - "structures", - "natural", - "tertiary", - "systems", - "properties", - "stability", - "control", - "replacement", "proteolytic", - "substitution", - "prototype", - "report", - "class", - "artificial", - "method", "subset", - "engineer", - "application", + "control", + "stability", + "viable", "blocks", - "agents", - "present", - "context", - "foldamers", - "foldamer", - "sequence", - "difficulty", - "protection", - "structural", + "low", + "use", + "scaffold", + "found", "compact", "inherent", - "bioactive", - "demonstrate", - "exciting", - "mimics", "undergo", - "mimicry", - "indistinguishable", - "peptides", - "found", + "difficulty", + "agents", + "context", + "topology", + "chain", + "expands", + "natural", + "enjoy", + "application", + "properties", + "leads", + "beyond", + "backbone", + "building", + "sequence", "repertoire", - "barriers", + "peptides", + "present", + "topologically", + "method", + "engineer", + "clean", "folds", + "designed", + "sequences", + "variants", + "structures", + "synthetic", + "report", + "herein", + "class", + "prototype", + "artificial", + "mimics", "systematic", - "scaffold", - "clean", - "creation", - "protein", - "backbone", - "development", - "various", - "collectively", - "folding", - "new" + "exerting", + "barriers", + "replacement", + "protection" ], "release_date":"2018-11-21", "publication":"\"Heterogeneous-Backbone Foldamer Mimics of a Computationally Designed, Disulfide-Rich Miniprotein\", Chembiochem, 20, 103-110", @@ -236302,84 +236876,84 @@ "heterogeneous backbone foldamer" ], "keywords":[ - "viable", - "results", - "herein", - "use", - "low", - "designed", - "enjoy", - "sequences", - "synthetic", - "topologically", "adopt", + "constrained", + "structural", + "development", + "collectively", "widespread", - "computationally", - "leads", - "however", - "building", - "exerting", - "chain", - "topology", + "results", + "foldamers", + "new", + "folding", + "various", + "foldamer", + "protein", + "demonstrate", + "systems", + "bioactive", + "indistinguishable", + "substitution", + "exciting", + "tertiary", "enables", - "variants", - "expands", - "beyond", - "constrained", + "however", + "creation", + "mimicry", + "computationally", "oxidative", - "structures", - "natural", - "tertiary", - "systems", - "properties", - "stability", - "control", - "replacement", "proteolytic", - "substitution", - "prototype", - "report", - "class", - "artificial", - "method", "subset", - "engineer", - "application", + "control", + "stability", + "viable", "blocks", - "agents", - "present", - "context", - "foldamers", - "foldamer", - "sequence", - "difficulty", - "protection", - "structural", + "low", + "use", + "scaffold", + "found", "compact", "inherent", - "bioactive", - "demonstrate", - "exciting", - "mimics", "undergo", - "mimicry", - "indistinguishable", - "peptides", - "found", + "difficulty", + "agents", + "context", + "topology", + "chain", + "expands", + "natural", + "enjoy", + "application", + "properties", + "leads", + "beyond", + "backbone", + "building", + "sequence", "repertoire", - "barriers", + "peptides", + "present", + "topologically", + "method", + "engineer", + "clean", "folds", + "designed", + "sequences", + "variants", + "structures", + "synthetic", + "report", + "herein", + "class", + "prototype", + "artificial", + "mimics", "systematic", - "scaffold", - "clean", - "creation", - "protein", - "backbone", - "development", - "various", - "collectively", - "folding", - "new" + "exerting", + "barriers", + "replacement", + "protection" ], "release_date":"2018-11-21", "publication":"\"Heterogeneous-Backbone Foldamer Mimics of a Computationally Designed, Disulfide-Rich Miniprotein\", Chembiochem, 20, 103-110", @@ -236412,11 +236986,11 @@ "seq_thr_sim_designed":[ { "sim":61.0, - "partner":"6e5h" + "partner":"6e5j" }, { "sim":61.0, - "partner":"6e5j" + "partner":"6e5h" }, { "sim":59.0, @@ -236438,7 +237012,7 @@ ], "seq_max_sim_designed":{ "sim":61.0, - "partner":"6e5h" + "partner":"6e5j" }, "seq_max_sim_natural":[ @@ -236494,84 +237068,84 @@ "heterogeneous backbone foldamer" ], "keywords":[ - "viable", - "results", - "herein", - "use", - "low", - "designed", - "enjoy", - "sequences", - "synthetic", - "topologically", "adopt", + "constrained", + "structural", + "development", + "collectively", "widespread", - "computationally", - "leads", - "however", - "building", - "exerting", - "chain", - "topology", + "results", + "foldamers", + "new", + "folding", + "various", + "foldamer", + "protein", + "demonstrate", + "systems", + "bioactive", + "indistinguishable", + "substitution", + "exciting", + "tertiary", "enables", - "variants", - "expands", - "beyond", - "constrained", + "however", + "creation", + "mimicry", + "computationally", "oxidative", - "structures", - "natural", - "tertiary", - "systems", - "properties", - "stability", - "control", - "replacement", "proteolytic", - "substitution", - "prototype", - "report", - "class", - "artificial", - "method", "subset", - "engineer", - "application", + "control", + "stability", + "viable", "blocks", - "agents", - "present", - "context", - "foldamers", - "foldamer", - "sequence", - "difficulty", - "protection", - "structural", + "low", + "use", + "scaffold", + "found", "compact", "inherent", - "bioactive", - "demonstrate", - "exciting", - "mimics", "undergo", - "mimicry", - "indistinguishable", - "peptides", - "found", + "difficulty", + "agents", + "context", + "topology", + "chain", + "expands", + "natural", + "enjoy", + "application", + "properties", + "leads", + "beyond", + "backbone", + "building", + "sequence", "repertoire", - "barriers", + "peptides", + "present", + "topologically", + "method", + "engineer", + "clean", "folds", + "designed", + "sequences", + "variants", + "structures", + "synthetic", + "report", + "herein", + "class", + "prototype", + "artificial", + "mimics", "systematic", - "scaffold", - "clean", - "creation", - "protein", - "backbone", - "development", - "various", - "collectively", - "folding", - "new" + "exerting", + "barriers", + "replacement", + "protection" ], "release_date":"2018-11-21", "publication":"\"Heterogeneous-Backbone Foldamer Mimics of a Computationally Designed, Disulfide-Rich Miniprotein\", Chembiochem, 20, 103-110", @@ -236686,84 +237260,84 @@ "heterogeneous backbone foldamer" ], "keywords":[ - "viable", - "results", - "herein", - "use", - "low", - "designed", - "enjoy", - "sequences", - "synthetic", - "topologically", "adopt", + "constrained", + "structural", + "development", + "collectively", "widespread", - "computationally", - "leads", - "however", - "building", - "exerting", - "chain", - "topology", + "results", + "foldamers", + "new", + "folding", + "various", + "foldamer", + "protein", + "demonstrate", + "systems", + "bioactive", + "indistinguishable", + "substitution", + "exciting", + "tertiary", "enables", - "variants", - "expands", - "beyond", - "constrained", + "however", + "creation", + "mimicry", + "computationally", "oxidative", - "structures", - "natural", - "tertiary", - "systems", - "properties", - "stability", - "control", - "replacement", "proteolytic", - "substitution", - "prototype", - "report", - "class", - "artificial", - "method", "subset", - "engineer", - "application", + "control", + "stability", + "viable", "blocks", - "agents", - "present", - "context", - "foldamers", - "foldamer", - "sequence", - "difficulty", - "protection", - "structural", + "low", + "use", + "scaffold", + "found", "compact", "inherent", - "bioactive", - "demonstrate", - "exciting", - "mimics", "undergo", - "mimicry", - "indistinguishable", - "peptides", - "found", + "difficulty", + "agents", + "context", + "topology", + "chain", + "expands", + "natural", + "enjoy", + "application", + "properties", + "leads", + "beyond", + "backbone", + "building", + "sequence", "repertoire", - "barriers", + "peptides", + "present", + "topologically", + "method", + "engineer", + "clean", "folds", + "designed", + "sequences", + "variants", + "structures", + "synthetic", + "report", + "herein", + "class", + "prototype", + "artificial", + "mimics", "systematic", - "scaffold", - "clean", - "creation", - "protein", - "backbone", - "development", - "various", - "collectively", - "folding", - "new" + "exerting", + "barriers", + "replacement", + "protection" ], "release_date":"2018-11-21", "publication":"\"Heterogeneous-Backbone Foldamer Mimics of a Computationally Designed, Disulfide-Rich Miniprotein\", Chembiochem, 20, 103-110", @@ -236796,11 +237370,11 @@ "seq_thr_sim_designed":[ { "sim":61.0, - "partner":"6e5h" + "partner":"6e5j" }, { "sim":61.0, - "partner":"6e5j" + "partner":"6e5h" }, { "sim":56.0, @@ -236822,7 +237396,7 @@ ], "seq_max_sim_designed":{ "sim":61.0, - "partner":"6e5h" + "partner":"6e5j" }, "seq_max_sim_natural":[ @@ -236939,72 +237513,72 @@ ], "subtitle":"Dhf58 filament", "tags":[ - "filament", "protein design", - "protein fibril" + "protein fibril", + "filament" ], "keywords":[ - "general", - "built", - "monomers", - "opens", - "designs", - "ordered", - "monomeric", - "one", - "proteins", + "metamaterials", + "geometries", + "designing", + "fabrication", "models", - "thus", + "engineered", + "design", + "controlled", + "dynamic", + "micrometers", + "one", "filaments", - "possibilities", - "use", - "approach", - "systematically", - "generate", - "close", - "wide", - "idealized", - "interaction", - "lacking", + "vivo", + "repeat", "number", - "geometries", - "diameter", + "opens", + "tuned", + "structures", + "built", + "idealized", + "thus", + "assembly", "disassembly", - "controlled", - "engineered", + "monomers", + "monomeric", + "generate", + "anchor", + "new", + "span", "surfaces", - "highly", - "vitro", + "protein", + "capping", "six", - "ability", - "assemble", + "wide", + "approach", "blocks", - "tuned", - "span", - "design", - "fabrication", - "units", "helical", - "structures", - "dynamic", + "proteins", + "vitro", + "interaction", "microscopy", - "protein", + "close", + "use", "filament", - "designing", - "capping", - "describe", - "assembly", - "repeat", "varying", - "computational", - "vivo", - "anchor", - "multiscale", - "metamaterials", + "units", + "general", + "diameter", + "ability", "building", - "micrometers", - "new", - "range" + "lacking", + "highly", + "possibilities", + "multiscale", + "describe", + "assemble", + "range", + "designs", + "computational", + "ordered", + "systematically" ], "release_date":"2018-11-21", "publication":"\"De novo design of self-assembling helical protein filaments\", Science, 362, 705-709", @@ -237273,72 +237847,72 @@ ], "subtitle":"Dhf79 filament", "tags":[ - "filament", "protein design", - "protein fibril" + "protein fibril", + "filament" ], "keywords":[ - "general", - "built", - "monomers", - "opens", - "designs", - "ordered", - "monomeric", - "one", - "proteins", + "metamaterials", + "geometries", + "designing", + "fabrication", "models", - "thus", + "engineered", + "design", + "controlled", + "dynamic", + "micrometers", + "one", "filaments", - "possibilities", - "use", - "approach", - "systematically", - "generate", - "close", - "wide", - "idealized", - "interaction", - "lacking", + "vivo", + "repeat", "number", - "geometries", - "diameter", + "opens", + "tuned", + "structures", + "built", + "idealized", + "thus", + "assembly", "disassembly", - "controlled", - "engineered", + "monomers", + "monomeric", + "generate", + "anchor", + "new", + "span", "surfaces", - "highly", - "vitro", + "protein", + "capping", "six", - "ability", - "assemble", + "wide", + "approach", "blocks", - "tuned", - "span", - "design", - "fabrication", - "units", "helical", - "structures", - "dynamic", + "proteins", + "vitro", + "interaction", "microscopy", - "protein", + "close", + "use", "filament", - "designing", - "capping", - "describe", - "assembly", - "repeat", "varying", - "computational", - "vivo", - "anchor", - "multiscale", - "metamaterials", + "units", + "general", + "diameter", + "ability", "building", - "micrometers", - "new", - "range" + "lacking", + "highly", + "possibilities", + "multiscale", + "describe", + "assemble", + "range", + "designs", + "computational", + "ordered", + "systematically" ], "release_date":"2018-11-21", "publication":"\"De novo design of self-assembling helical protein filaments\", Science, 362, 705-709", @@ -237606,72 +238180,72 @@ ], "subtitle":"Dhf38 filament", "tags":[ - "filament", "protein design", - "protein fibril" + "protein fibril", + "filament" ], "keywords":[ - "general", - "built", - "monomers", - "opens", - "designs", - "ordered", - "monomeric", - "one", - "proteins", + "metamaterials", + "geometries", + "designing", + "fabrication", "models", - "thus", + "engineered", + "design", + "controlled", + "dynamic", + "micrometers", + "one", "filaments", - "possibilities", - "use", - "approach", - "systematically", - "generate", - "close", - "wide", - "idealized", - "interaction", - "lacking", + "vivo", + "repeat", "number", - "geometries", - "diameter", + "opens", + "tuned", + "structures", + "built", + "idealized", + "thus", + "assembly", "disassembly", - "controlled", - "engineered", + "monomers", + "monomeric", + "generate", + "anchor", + "new", + "span", "surfaces", - "highly", - "vitro", + "protein", + "capping", "six", - "ability", - "assemble", + "wide", + "approach", "blocks", - "tuned", - "span", - "design", - "fabrication", - "units", "helical", - "structures", - "dynamic", + "proteins", + "vitro", + "interaction", "microscopy", - "protein", + "close", + "use", "filament", - "designing", - "capping", - "describe", - "assembly", - "repeat", "varying", - "computational", - "vivo", - "anchor", - "multiscale", - "metamaterials", + "units", + "general", + "diameter", + "ability", "building", - "micrometers", - "new", - "range" + "lacking", + "highly", + "possibilities", + "multiscale", + "describe", + "assemble", + "range", + "designs", + "computational", + "ordered", + "systematically" ], "release_date":"2018-11-21", "publication":"\"De novo design of self-assembling helical protein filaments\", Science, 362, 705-709", @@ -237784,11 +238358,11 @@ }, { "sim":68.0, - "partner":"7udm" + "partner":"7udn" }, { "sim":68.0, - "partner":"7udn" + "partner":"7udm" }, { "sim":66.0, @@ -237956,72 +238530,72 @@ ], "subtitle":"Dhf119 filament", "tags":[ - "filament", "protein design", - "protein fibril" + "protein fibril", + "filament" ], "keywords":[ - "general", - "built", - "monomers", - "opens", - "designs", - "ordered", - "monomeric", - "one", - "proteins", + "metamaterials", + "geometries", + "designing", + "fabrication", "models", - "thus", + "engineered", + "design", + "controlled", + "dynamic", + "micrometers", + "one", "filaments", - "possibilities", - "use", - "approach", - "systematically", - "generate", - "close", - "wide", - "idealized", - "interaction", - "lacking", + "vivo", + "repeat", "number", - "geometries", - "diameter", + "opens", + "tuned", + "structures", + "built", + "idealized", + "thus", + "assembly", "disassembly", - "controlled", - "engineered", + "monomers", + "monomeric", + "generate", + "anchor", + "new", + "span", "surfaces", - "highly", - "vitro", + "protein", + "capping", "six", - "ability", - "assemble", + "wide", + "approach", "blocks", - "tuned", - "span", - "design", - "fabrication", - "units", "helical", - "structures", - "dynamic", + "proteins", + "vitro", + "interaction", "microscopy", - "protein", + "close", + "use", "filament", - "designing", - "capping", - "describe", - "assembly", - "repeat", "varying", - "computational", - "vivo", - "anchor", - "multiscale", - "metamaterials", + "units", + "general", + "diameter", + "ability", "building", - "micrometers", - "new", - "range" + "lacking", + "highly", + "possibilities", + "multiscale", + "describe", + "assemble", + "range", + "designs", + "computational", + "ordered", + "systematically" ], "release_date":"2018-11-21", "publication":"\"De novo design of self-assembling helical protein filaments\", Science, 362, 705-709", @@ -238245,123 +238819,123 @@ ], "subtitle":"Reactive centre loop dynamics and serpin specificity", "tags":[ - "protein engineering", "protein dynamics", - "de novo protein" + "de novo protein", + "protein engineering" ], "keywords":[ - "require", - "aggregation", - "change", - "studies", - "thus", - "specificity", - "use", + "whether", + "engineering", + "molecular", + "rate", + "manipulating", "delicate", - "inhibitor", - "misfolding", - "determination", - "substantially", - "protease", - "local", - "towards", - "achieves", - "target", - "lability", - "order", - "synthetic", - "\u03b1", - "rcl", - "therefore", - "underlies", - "proteinase", - "inhibitors", - "solely", - "however", + "structural", "thermostable", + "therefore", + "well", + "serpins", + "thorough", + "lability", + "inhibitor", + "replacing", + "folding", "deficiency", - "interaction", - "reactive", - "centre", + "behaves", + "model", + "protein", + "solely", "partially", - "serpins", - "attempted", - "although", - "whether", - "dictate", - "balance", - "electrostatics", + "\u03b1", + "exquisite", + "susceptible", + "forms", + "major", + "rules", + "centre", + "underlies", + "previous", + "enough", + "simulations", + "complex", "typically", - "paper", - "substrate", - "yet", + "engineered", "initial", - "dynamics", - "alter", - "trypsin", - "enough", - "metastable", - "conserpin", + "conformational", + "however", + "specificity", + "governing", + "action", "serpin", - "mutating", - "function", - "native", - "solvent", - "rules", - "thorough", - "exposed", - "investigate", + "determination", + "thus", + "electrostatics", + "aggregation", + "although", + "fails", "stability", - "loop", - "molecular", - "elastase", - "serine", - "1", + "use", "may", - "manipulating", - "simulations", - "exquisite", - "dictated", - "engineering", - "rate", - "replacing", - "model", - "action", + "metastable", + "balance", "restore", + "neutrophil", + "serine", + "1", + "elastase", + "investigate", "required", - "insertion", - "sequence", - "fails", - "indicate", - "structural", - "governing", - "susceptible", "undergo", - "renders", - "conformational", - "flexible", + "misfolding", + "protease", + "conserpin", + "local", "inhibit", - "human", + "substrate", + "yet", "fold", - "enable", - "well", - "engineered", - "understood", - "determinants", - "state", - "neutrophil", + "insertion", "proteases", + "interaction", + "understood", + "renders", + "dictate", + "sequence", + "reactive", + "substantially", "inhibition", "mechanism", - "protein", - "previous", - "complex", + "dynamics", + "order", + "determinants", + "require", + "indicate", + "exposed", + "loop", + "attempted", + "dictated", + "synthetic", + "flexible", + "rcl", + "target", + "state", + "inhibitors", + "function", "understanding", "diseases", - "behaves", - "major", - "folding", - "forms" + "enable", + "change", + "towards", + "proteinase", + "native", + "alter", + "mutating", + "solvent", + "studies", + "trypsin", + "human", + "achieves", + "paper" ], "release_date":"2018-08-29", "publication":"\"Reactive centre loop dynamics and serpin specificity\", Sci Rep, 9, 3870-3870", @@ -238420,16 +238994,16 @@ "partner":"4pyw" }, { - "sim":441.0, - "partner":"1atu" + "sim":443.0, + "partner":"8r13" }, { "sim":441.0, - "partner":"5nbv" + "partner":"1atu" }, { "sim":441.0, - "partner":"1oph" + "partner":"5nbv" }, { "sim":441.0, @@ -238441,7 +239015,7 @@ }, { "sim":441.0, - "partner":"8qz5" + "partner":"1oph" }, { "sim":441.0, @@ -238449,11 +239023,11 @@ }, { "sim":441.0, - "partner":"3ne4" + "partner":"8qz5" }, { - "sim":440.0, - "partner":"1iz2" + "sim":441.0, + "partner":"3ne4" }, { "sim":440.0, @@ -238463,6 +239037,10 @@ "sim":440.0, "partner":"3cwm" }, + { + "sim":440.0, + "partner":"1iz2" + }, { "sim":440.0, "partner":"2qug" @@ -238501,15 +239079,15 @@ }, { "sim":395.0, - "partner":"8api" + "partner":"9api" }, { "sim":395.0, - "partner":"9api" + "partner":"7api" }, { "sim":395.0, - "partner":"7api" + "partner":"8api" }, { "sim":392.0, @@ -238633,15 +239211,15 @@ }, { "sim":325.0, - "partner":"2xn5" + "partner":"2xn6" }, { "sim":325.0, - "partner":"2xn6" + "partner":"2xn7" }, { "sim":325.0, - "partner":"2xn7" + "partner":"2xn5" }, { "sim":324.0, @@ -238735,14 +239313,6 @@ "sim":267.0, "partner":"1br8" }, - { - "sim":267.0, - "partner":"1nq9" - }, - { - "sim":267.0, - "partner":"2b5t" - }, { "sim":267.0, "partner":"1lk6" @@ -238759,10 +239329,6 @@ "sim":267.0, "partner":"2ant" }, - { - "sim":267.0, - "partner":"1ant" - }, { "sim":267.0, "partner":"1tb6" @@ -238781,7 +239347,7 @@ }, { "sim":267.0, - "partner":"1azx" + "partner":"1ant" }, { "sim":267.0, @@ -238791,6 +239357,10 @@ "sim":267.0, "partner":"2znh" }, + { + "sim":267.0, + "partner":"1azx" + }, { "sim":267.0, "partner":"2hij" @@ -238799,6 +239369,10 @@ "sim":267.0, "partner":"1sr5" }, + { + "sim":267.0, + "partner":"4eb1" + }, { "sim":267.0, "partner":"1e03" @@ -238809,7 +239383,7 @@ }, { "sim":267.0, - "partner":"4eb1" + "partner":"1jvq" }, { "sim":267.0, @@ -238817,11 +239391,15 @@ }, { "sim":267.0, - "partner":"1jvq" + "partner":"1ath" }, { "sim":267.0, - "partner":"1ath" + "partner":"1nq9" + }, + { + "sim":267.0, + "partner":"2b5t" }, { "sim":267.0, @@ -238957,11 +239535,11 @@ }, { "sim":242.0, - "partner":"1dvm" + "partner":"3lw2" }, { "sim":242.0, - "partner":"3lw2" + "partner":"1dvm" }, { "sim":242.0, @@ -239033,11 +239611,11 @@ }, { "sim":218.0, - "partner":"4p0o" + "partner":"4p0f" }, { "sim":218.0, - "partner":"4p0f" + "partner":"4p0o" }, { "sim":212.0, @@ -239059,10 +239637,6 @@ "sim":204.0, "partner":"5ncs" }, - { - "sim":194.0, - "partner":"4au2" - }, { "sim":194.0, "partner":"4au3" @@ -239075,6 +239649,10 @@ "sim":194.0, "partner":"4au4" }, + { + "sim":194.0, + "partner":"4au2" + }, { "sim":192.0, "partner":"3le2" @@ -239193,15 +239771,15 @@ }, { "sim":105.0, - "partner":"2wxx" + "partner":"2wy0" }, { "sim":105.0, - "partner":"2wxy" + "partner":"2wxx" }, { "sim":105.0, - "partner":"2wy0" + "partner":"2wxy" }, { "sim":101.0, @@ -239312,76 +239890,76 @@ "coiled-coil" ], "keywords":[ + "designed", + "surface", + "dimensions", + "design", + "symmetry", + "ten", "array", - "general", - "layer", - "toward", "interfaces", - "c12", - "100", - "monomeric", - "nm", - "proteins", - "via", - "orthogonal", "specificity", "redesigned", - "dna", - "lack", - "approach", - "similar", - "homodimeric", + "scale", + "displayed", + "2d", + "geometry", + "atomic", "de", - "novo", + "due", "group", - "stain", - "straightforward", - "geometry", + "dna", + "step", + "micrometer", + "assembly", + "nm", + "via", + "important", + "monomeric", "rosetta", - "designed", + "programmable", + "block", + "reconnected", + "patterning", + "assembled", + "layer", + "protein", + "orthogonal", + "homodimeric", + "approach", + "blocks", + "proteins", + "helical", + "stain", + "biomolecules", + "pairing", + "electron", + "force", + "binding", + "size", + "microscopy", "enable", "modular", - "electron", "lattice", - "patterning", - "dimensions", - "programmable", + "general", + "straightforward", + "arrays", + "novo", + "negative", + "building", "difficult", - "biomolecules", + "c12", "two", - "due", - "step", - "blocks", - "bundle", - "design", - "helical", - "reconnected", + "toward", "pseudosymmetric", - "arrays", - "using", - "protein", - "assembled", - "scale", - "pairing", - "negative", - "microscopy", - "displayed", - "surface", "describe", - "symmetry", - "assembly", - "block", - "micrometer", - "atomic", - "force", - "size", "realize", - "building", - "2d", - "binding", - "important", + "100", + "bundle", + "using", + "similar", "base", - "ten" + "lack" ], "release_date":"2019-05-29", "publication":"\"Self-Assembling 2D Arrays with de Novo Protein Building Blocks\", J.Am.Chem.Soc., 141, 8891-8895", @@ -239493,120 +240071,120 @@ ], "subtitle":"Crystal structure of a de novo three-stranded coiled coil peptide containing a d-leu in the second coordination sphere of a non-metalated tris-thiolate binding site", "tags":[ - "d-leu", "tris-thiolate binding site", - "engineered protein by d-amino acids", "de novo protein", - "de novo three-stranded coiled coil peptide" + "d-leu", + "de novo three-stranded coiled coil peptide", + "engineered protein by d-amino acids" ], "keywords":[ "tune", - "opens", - "studies", - "causing", - "pyramidal", - "metal", + "insights", + "spheres", + "number", + "cavity", + "perturbed", + "excess", + "trigonal", + "question", + "metalloprotein", + "core", + "side", + "three", + "explain", + "lead", + "within", + "oh", + "residue", "pb", - "allowing", "cd", - "geometries", - "hg", - "provide", + "plane", "tri", - "towards", - "outer", - "ii", - "oh", - "insights", - "however", - "restricts", - "spectroscopic", - "coiled", - "chain", - "proteins", - "trigonal", + "x", + "little", + "thiophilic", "coordination", - "de", - "facilitating", + "site", + "novo", + "rotation", "yielding", - "number", - "spheres", - "leu", - "used", - "little", - "shift", - "3", - "cavity", - "forming", + "mercurated", + "forms", + "substitution", + "hg", + "using", + "water", + "metal", + "however", + "metalloproteins", + "examination", + "metals", "unfortunately", - "lead", - "structures", - "coils", - "three", - "compared", - "stranded", "thiol", - "displaces", - "planar", - "properties", - "pen", - "metalloprotein", "layer", "control", - "replacement", - "yields", - "mercurated", - "substitution", - "amino", - "reveals", - "geometry", - "acids", - "challenging", "address", - "active", + "modifications", + "proteins", + "outer", + "2", "iii", - "shown", - "examination", - "result", + "pen", + "coils", + "leu", + "ala", + "allowing", + "forming", + "geometries", + "spectroscopic", + "challenging", "design", - "metals", - "core", - "crystallographic", - "rotation", - "using", + "compared", + "chain", + "active", + "used", "reorients", + "pyramidal", + "properties", + "shift", + "shown", + "amino", + "reveals", + "peptides", "diminishing", - "equal", - "question", - "observations", - "novo", - "plane", - "metalloproteins", - "thiophilic", + "displaces", + "whereas", + "crystallographic", "desired", - "peptides", - "cys", - "modifications", - "ala", - "objective", - "explain", - "variation", - "residue", - "2", - "space", - "water", - "coded", + "causing", "coilser", - "within", + "space", + "planar", + "geometry", + "opens", + "structures", + "de", + "yields", + "3", + "provide", "accommodation", - "excess", - "x", - "perturbed", - "side", - "site", "fine", - "forms", - "whereas" + "objective", + "cys", + "coiled", + "restricts", + "towards", + "coded", + "result", + "acids", + "facilitating", + "studies", + "equal", + "replacement", + "stranded", + "variation", + "observations", + "ii" ], "release_date":"2019-04-03", "publication":"\"How Outer Coordination Sphere Modifications Can Impact Metal Structures in Proteins: A Crystallographic Evaluation\", Chemistry, 25, 6773-6787", @@ -239647,15 +240225,15 @@ }, { "sim":67.0, - "partner":"6ego" + "partner":"7n2y" }, { "sim":67.0, - "partner":"6egp" + "partner":"6ego" }, { "sim":67.0, - "partner":"7n2y" + "partner":"5kb2" }, { "sim":67.0, @@ -239663,7 +240241,7 @@ }, { "sim":67.0, - "partner":"5kb2" + "partner":"6egp" }, { "sim":66.0, @@ -239679,7 +240257,7 @@ }, { "sim":51.0, - "partner":"5u9u" + "partner":"5u9t" }, { "sim":51.0, @@ -239687,7 +240265,7 @@ }, { "sim":51.0, - "partner":"5u9t" + "partner":"5u9u" } ], "seq_thr_sim_natural":[ @@ -239781,120 +240359,120 @@ "subtitle":"Crystal structure of a de novo three-stranded coiled coil peptide containing d-leu in a d-site position of a tris-thiolate binding site", "tags":[ "metalloprotein", - "d-leu", - "three-stranded coiled coil peptide", - "d-amino acids", + "engineered protein", "de novo protein", - "engineered protein" + "three-stranded coiled coil peptide", + "d-leu", + "d-amino acids" ], "keywords":[ "tune", - "opens", - "studies", - "causing", - "pyramidal", - "metal", + "insights", + "spheres", + "number", + "cavity", + "perturbed", + "excess", + "trigonal", + "question", + "metalloprotein", + "core", + "side", + "three", + "explain", + "lead", + "within", + "oh", + "residue", "pb", - "allowing", "cd", - "geometries", - "hg", - "provide", + "plane", "tri", - "towards", - "outer", - "ii", - "oh", - "insights", - "however", - "restricts", - "spectroscopic", - "coiled", - "chain", - "proteins", - "trigonal", + "x", + "little", + "thiophilic", "coordination", - "de", - "facilitating", + "site", + "novo", + "rotation", "yielding", - "number", - "spheres", - "leu", - "used", - "little", - "shift", - "3", - "cavity", - "forming", + "mercurated", + "forms", + "substitution", + "hg", + "using", + "water", + "metal", + "however", + "metalloproteins", + "examination", + "metals", "unfortunately", - "lead", - "structures", - "coils", - "three", - "compared", - "stranded", "thiol", - "displaces", - "planar", - "properties", - "pen", - "metalloprotein", "layer", "control", - "replacement", - "yields", - "mercurated", - "substitution", - "amino", - "reveals", - "geometry", - "acids", - "challenging", "address", - "active", + "modifications", + "proteins", + "outer", + "2", "iii", - "shown", - "examination", - "result", + "pen", + "coils", + "leu", + "ala", + "allowing", + "forming", + "geometries", + "spectroscopic", + "challenging", "design", - "metals", - "core", - "crystallographic", - "rotation", - "using", + "compared", + "chain", + "active", + "used", "reorients", + "pyramidal", + "properties", + "shift", + "shown", + "amino", + "reveals", + "peptides", "diminishing", - "equal", - "question", - "observations", - "novo", - "plane", - "metalloproteins", - "thiophilic", + "displaces", + "whereas", + "crystallographic", "desired", - "peptides", - "cys", - "modifications", - "ala", - "objective", - "explain", - "variation", - "residue", - "2", - "space", - "water", - "coded", + "causing", "coilser", - "within", + "space", + "planar", + "geometry", + "opens", + "structures", + "de", + "yields", + "3", + "provide", "accommodation", - "excess", - "x", - "perturbed", - "side", - "site", "fine", - "forms", - "whereas" + "objective", + "cys", + "coiled", + "restricts", + "towards", + "coded", + "result", + "acids", + "facilitating", + "studies", + "equal", + "replacement", + "stranded", + "variation", + "observations", + "ii" ], "release_date":"2019-04-03", "publication":"\"How Outer Coordination Sphere Modifications Can Impact Metal Structures in Proteins: A Crystallographic Evaluation\", Chemistry, 25, 6773-6787", @@ -239935,15 +240513,15 @@ }, { "sim":67.0, - "partner":"6ego" + "partner":"7n2y" }, { "sim":67.0, - "partner":"6egp" + "partner":"6ego" }, { "sim":67.0, - "partner":"7n2y" + "partner":"5kb2" }, { "sim":67.0, @@ -239951,7 +240529,7 @@ }, { "sim":67.0, - "partner":"5kb2" + "partner":"6egp" }, { "sim":66.0, @@ -239967,7 +240545,7 @@ }, { "sim":51.0, - "partner":"5u9u" + "partner":"5u9t" }, { "sim":51.0, @@ -239975,7 +240553,7 @@ }, { "sim":51.0, - "partner":"5u9t" + "partner":"5u9u" } ], "seq_thr_sim_natural":[ @@ -240080,121 +240658,121 @@ ], "subtitle":"Crystal structure of a three-stranded coiled coil peptide containing a trigonal planar hg(ii)s3 site modified by d-leu in the second coordination sphere", "tags":[ - "d-leu", - "trigonal planar hg(ii) structure", "hg(ii)s3 complex", - "d-amino acids", + "trigonal planar hg(ii) structure", "de novo protein", - "de novo three-stranded helical coiled coil peptide" + "d-leu", + "de novo three-stranded helical coiled coil peptide", + "d-amino acids" ], "keywords":[ "tune", - "opens", - "studies", - "causing", - "pyramidal", - "metal", + "insights", + "spheres", + "number", + "cavity", + "perturbed", + "excess", + "trigonal", + "question", + "metalloprotein", + "core", + "side", + "three", + "explain", + "lead", + "within", + "oh", + "residue", "pb", - "allowing", "cd", - "geometries", - "hg", - "provide", + "plane", "tri", - "towards", - "outer", - "ii", - "oh", - "insights", - "however", - "restricts", - "spectroscopic", - "coiled", - "chain", - "proteins", - "trigonal", + "x", + "little", + "thiophilic", "coordination", - "de", - "facilitating", + "site", + "novo", + "rotation", "yielding", - "number", - "spheres", - "leu", - "used", - "little", - "shift", - "3", - "cavity", - "forming", + "mercurated", + "forms", + "substitution", + "hg", + "using", + "water", + "metal", + "however", + "metalloproteins", + "examination", + "metals", "unfortunately", - "lead", - "structures", - "coils", - "three", - "compared", - "stranded", "thiol", - "displaces", - "planar", - "properties", - "pen", - "metalloprotein", "layer", "control", - "replacement", - "yields", - "mercurated", - "substitution", - "amino", - "reveals", - "geometry", - "acids", - "challenging", "address", - "active", + "modifications", + "proteins", + "outer", + "2", "iii", - "shown", - "examination", - "result", + "pen", + "coils", + "leu", + "ala", + "allowing", + "forming", + "geometries", + "spectroscopic", + "challenging", "design", - "metals", - "core", - "crystallographic", - "rotation", - "using", + "compared", + "chain", + "active", + "used", "reorients", + "pyramidal", + "properties", + "shift", + "shown", + "amino", + "reveals", + "peptides", "diminishing", - "equal", - "question", - "observations", - "novo", - "plane", - "metalloproteins", - "thiophilic", + "displaces", + "whereas", + "crystallographic", "desired", - "peptides", - "cys", - "modifications", - "ala", - "objective", - "explain", - "variation", - "residue", - "2", - "space", - "water", - "coded", + "causing", "coilser", - "within", + "space", + "planar", + "geometry", + "opens", + "structures", + "de", + "yields", + "3", + "provide", "accommodation", - "excess", - "x", - "perturbed", - "side", - "site", "fine", - "forms", - "whereas" + "objective", + "cys", + "coiled", + "restricts", + "towards", + "coded", + "result", + "acids", + "facilitating", + "studies", + "equal", + "replacement", + "stranded", + "variation", + "observations", + "ii" ], "release_date":"2019-04-03", "publication":"\"How Outer Coordination Sphere Modifications Can Impact Metal Structures in Proteins: A Crystallographic Evaluation\", Chemistry, 25, 6773-6787", @@ -240235,15 +240813,15 @@ }, { "sim":67.0, - "partner":"6ego" + "partner":"7n2y" }, { "sim":67.0, - "partner":"6egp" + "partner":"6ego" }, { "sim":67.0, - "partner":"7n2y" + "partner":"5kb2" }, { "sim":67.0, @@ -240251,7 +240829,7 @@ }, { "sim":67.0, - "partner":"5kb2" + "partner":"6egp" }, { "sim":66.0, @@ -240267,7 +240845,7 @@ }, { "sim":51.0, - "partner":"5u9u" + "partner":"5u9t" }, { "sim":51.0, @@ -240275,7 +240853,7 @@ }, { "sim":51.0, - "partner":"5u9t" + "partner":"5u9u" } ], "seq_thr_sim_natural":[ @@ -240387,112 +240965,112 @@ ], "keywords":[ "tune", - "opens", - "studies", - "causing", - "pyramidal", - "metal", + "insights", + "spheres", + "number", + "cavity", + "perturbed", + "excess", + "trigonal", + "question", + "metalloprotein", + "core", + "side", + "three", + "explain", + "lead", + "within", + "oh", + "residue", "pb", - "allowing", "cd", - "geometries", - "hg", - "provide", + "plane", "tri", - "towards", - "outer", - "ii", - "oh", - "insights", - "however", - "restricts", - "spectroscopic", - "coiled", - "chain", - "proteins", - "trigonal", + "x", + "little", + "thiophilic", "coordination", - "de", - "facilitating", + "site", + "novo", + "rotation", "yielding", - "number", - "spheres", - "leu", - "used", - "little", - "shift", - "3", - "cavity", - "forming", + "mercurated", + "forms", + "substitution", + "hg", + "using", + "water", + "metal", + "however", + "metalloproteins", + "examination", + "metals", "unfortunately", - "lead", - "structures", - "coils", - "three", - "compared", - "stranded", "thiol", - "displaces", - "planar", - "properties", - "pen", - "metalloprotein", "layer", "control", - "replacement", - "yields", - "mercurated", - "substitution", - "amino", - "reveals", - "geometry", - "acids", - "challenging", "address", - "active", + "modifications", + "proteins", + "outer", + "2", "iii", - "shown", - "examination", - "result", + "pen", + "coils", + "leu", + "ala", + "allowing", + "forming", + "geometries", + "spectroscopic", + "challenging", "design", - "metals", - "core", - "crystallographic", - "rotation", - "using", + "compared", + "chain", + "active", + "used", "reorients", + "pyramidal", + "properties", + "shift", + "shown", + "amino", + "reveals", + "peptides", "diminishing", - "equal", - "question", - "observations", - "novo", - "plane", - "metalloproteins", - "thiophilic", + "displaces", + "whereas", + "crystallographic", "desired", - "peptides", - "cys", - "modifications", - "ala", - "objective", - "explain", - "variation", - "residue", - "2", - "space", - "water", - "coded", + "causing", "coilser", - "within", + "space", + "planar", + "geometry", + "opens", + "structures", + "de", + "yields", + "3", + "provide", "accommodation", - "excess", - "x", - "perturbed", - "side", - "site", "fine", - "forms", - "whereas" + "objective", + "cys", + "coiled", + "restricts", + "towards", + "coded", + "result", + "acids", + "facilitating", + "studies", + "equal", + "replacement", + "stranded", + "variation", + "observations", + "ii" ], "release_date":"2019-04-03", "publication":"\"How Outer Coordination Sphere Modifications Can Impact Metal Structures in Proteins: A Crystallographic Evaluation\", Chemistry, 25, 6773-6787", @@ -240525,11 +241103,11 @@ "seq_thr_sim_designed":[ { "sim":69.0, - "partner":"6egp" + "partner":"5kb2" }, { "sim":69.0, - "partner":"5kb2" + "partner":"6egp" }, { "sim":67.0, @@ -240610,7 +241188,7 @@ ], "seq_max_sim_designed":{ "sim":69.0, - "partner":"6egp" + "partner":"5kb2" }, "seq_max_sim_natural":[ @@ -240663,10 +241241,10 @@ "subtitle":"Crystal structure of a trigonal pyramidal pb(ii)s3 complex in a three-stranded coiled coil peptide", "tags":[ "metalloprotein", - "trigonal pyramidal pb(ii)s3", + "tris-thiolate", "de novo protein", - "de novo three-stranded coiled coil peptide", - "tris-thiolate" + "trigonal pyramidal pb(ii)s3", + "de novo three-stranded coiled coil peptide" ], "keywords":[ "description", @@ -240864,75 +241442,75 @@ "alpha-helical coiled-coil barrel" ], "keywords":[ - "variant", "environmentally", + "constants", + "central", + "engineered", + "introducing", + "heptameric", + "cationic", + "hydrophobic", + "submicromolar", "displacement", + "scale", + "show", "lysine", - "allows", - "chains", - "channels", - "facilitate", - "pentameric", - "reveals", - "hexamer", - "micromolar", - "barrels", + "active", + "used", "de", - "report", "discriminate", - "inhibitor", - "cationic", - "acid", - "nonfluorescent", - "biologically", + "oriented", + "lumen", + "dph", "\u03b1hbs", - "channel", + "around", + "side", + "three", "dye", - "biosynthetically", - "sensitive", - "retinol", - "engineered", - "used", - "active", + "structure", + "important", + "acid", + "report", + "inhibitor", + "polar", + "ligands", + "variant", + "pentameric", "farnesol", - "constants", - "diameters", - "dph", - "binds", - "glutamate", + "biologically", "state", + "lipophilic", + "bind", "palmitic", - "central", - "hexameric", - "polar", - "show", + "retinol", + "biosynthetically", + "binding", + "molecules", + "oligomer", + "allows", "arranged", - "oriented", - "lumen", - "bind", - "scale", - "submicromolar", - "fluoresce", "center", - "hydrophobic", - "diphosphate", "charged", - "describe", - "structure", - "three", - "lipophilic", - "ligands", - "introducing", - "oligomer", - "heptameric", - "side", - "molecules", - "around", - "binding", + "channels", + "fluoresce", + "reveals", + "glutamate", + "channel", + "diameters", + "diphosphate", + "nonfluorescent", "heptamer", - "important", - "five", - "range" + "describe", + "range", + "micromolar", + "binds", + "chains", + "facilitate", + "hexamer", + "sensitive", + "barrels", + "hexameric", + "five" ], "release_date":"2018-07-18", "publication":"\"De Novo-Designed alpha-Helical Barrels as Receptors for Small Molecules\", ACS Synth Biol, 7, 1808-1816", @@ -240977,6 +241555,10 @@ "sim":1.0, "partner":"7nfn" }, + { + "sim":0.9607999921, + "partner":"5eze" + }, { "sim":1.0, "partner":"5ez9" @@ -241097,14 +241679,14 @@ "sim":0.9966999888, "partner":"7nfg" }, - { - "sim":1.0, - "partner":"6g6g" - }, { "sim":0.9934999943, "partner":"7nfi" }, + { + "sim":1.0, + "partner":"6g6g" + }, { "sim":0.9886000156, "partner":"7bo9" @@ -241113,10 +241695,18 @@ "sim":0.9914000034, "partner":"6yb2" }, + { + "sim":0.9713000059, + "partner":"6yb0" + }, { "sim":0.9941999912, "partner":"6g6d" }, + { + "sim":0.9739000201, + "partner":"6yaz" + }, { "sim":0.994599998, "partner":"6g6c" @@ -241137,29 +241727,17 @@ "sim":0.9951000214, "partner":"6g66" }, - { - "sim":0.9749000072, - "partner":"6xxz" - }, { "sim":0.9958999753, "partner":"7bo8" }, { - "sim":0.9606000185, - "partner":"4dzk" - }, - { - "sim":0.9607999921, - "partner":"5eze" - }, - { - "sim":0.9713000059, - "partner":"6yb0" + "sim":0.9749000072, + "partner":"6xxz" }, { - "sim":0.9739000201, - "partner":"6yaz" + "sim":0.9606000185, + "partner":"4dzk" }, { "sim":0.9743999839, @@ -241262,75 +241840,75 @@ "alpha-helical coiled-coil barrel" ], "keywords":[ - "variant", "environmentally", + "constants", + "central", + "engineered", + "introducing", + "heptameric", + "cationic", + "hydrophobic", + "submicromolar", "displacement", + "scale", + "show", "lysine", - "allows", - "chains", - "channels", - "facilitate", - "pentameric", - "reveals", - "hexamer", - "micromolar", - "barrels", + "active", + "used", "de", - "report", "discriminate", - "inhibitor", - "cationic", - "acid", - "nonfluorescent", - "biologically", + "oriented", + "lumen", + "dph", "\u03b1hbs", - "channel", + "around", + "side", + "three", "dye", - "biosynthetically", - "sensitive", - "retinol", - "engineered", - "used", - "active", + "structure", + "important", + "acid", + "report", + "inhibitor", + "polar", + "ligands", + "variant", + "pentameric", "farnesol", - "constants", - "diameters", - "dph", - "binds", - "glutamate", + "biologically", "state", + "lipophilic", + "bind", "palmitic", - "central", - "hexameric", - "polar", - "show", + "retinol", + "biosynthetically", + "binding", + "molecules", + "oligomer", + "allows", "arranged", - "oriented", - "lumen", - "bind", - "scale", - "submicromolar", - "fluoresce", "center", - "hydrophobic", - "diphosphate", "charged", - "describe", - "structure", - "three", - "lipophilic", - "ligands", - "introducing", - "oligomer", - "heptameric", - "side", - "molecules", - "around", - "binding", + "channels", + "fluoresce", + "reveals", + "glutamate", + "channel", + "diameters", + "diphosphate", + "nonfluorescent", "heptamer", - "important", - "five", - "range" + "describe", + "range", + "micromolar", + "binds", + "chains", + "facilitate", + "hexamer", + "sensitive", + "barrels", + "hexameric", + "five" ], "release_date":"2018-07-11", "publication":"\"De Novo-Designed alpha-Helical Barrels as Receptors for Small Molecules\", ACS Synth Biol, 7, 1808-1816", @@ -241375,10 +241953,6 @@ "sim":1.0, "partner":"8a09" }, - { - "sim":1.0, - "partner":"7bav" - }, { "sim":0.9986000061, "partner":"8b16" @@ -241392,136 +241966,124 @@ "partner":"7bas" }, { - "sim":0.9984999895, - "partner":"7bim" + "sim":1.0, + "partner":"7bav" }, { - "sim":1.0, - "partner":"6xy1" + "sim":0.9984999895, + "partner":"7bim" }, { "sim":1.0, "partner":"7a1t" }, { - "sim":1.0, - "partner":"7nfo" + "sim":0.9966999888, + "partner":"6g6d" }, { "sim":1.0, - "partner":"7nfj" + "partner":"6xy1" }, { - "sim":0.9984999895, - "partner":"7nfl" + "sim":0.9986000061, + "partner":"7nfg" }, { "sim":1.0, "partner":"4pna" }, - { - "sim":0.9966999888, - "partner":"6g6d" - }, - { - "sim":0.9973000288, - "partner":"5ez8" - }, { "sim":1.0, - "partner":"7nfk" + "partner":"6yb2" }, { "sim":1.0, - "partner":"7nfh" + "partner":"7nfo" }, { - "sim":0.9961000085, - "partner":"7bat" + "sim":0.9965000153, + "partner":"7nff" }, { "sim":1.0, - "partner":"6g6f" + "partner":"7nfj" }, { - "sim":1.0, - "partner":"7baw" + "sim":0.9973000288, + "partner":"5ez8" }, { - "sim":0.9970999956, - "partner":"7bau" + "sim":0.9977999926, + "partner":"7nfi" }, { - "sim":0.9990000129, - "partner":"5ez9" + "sim":0.9984999895, + "partner":"7nfl" }, { - "sim":0.9990000129, - "partner":"6eik" + "sim":0.9894000292, + "partner":"7nfm" }, { "sim":1.0, - "partner":"6g6g" + "partner":"6g6f" }, { "sim":1.0, - "partner":"7nfn" - }, - { - "sim":0.9986000061, - "partner":"7nfg" + "partner":"6g6g" }, { "sim":1.0, - "partner":"5ezc" + "partner":"7nfk" }, { - "sim":1.0, - "partner":"6yb2" + "sim":0.9990000129, + "partner":"5ez9" }, { - "sim":0.9965000153, - "partner":"7nff" + "sim":0.9961000085, + "partner":"7bat" }, { - "sim":0.9894000292, - "partner":"7nfm" + "sim":1.0, + "partner":"7nfh" }, { - "sim":0.9984999895, - "partner":"6g6b" + "sim":1.0, + "partner":"7baw" }, { - "sim":1.0, - "partner":"6zt1" + "sim":0.9990000129, + "partner":"6eik" }, { - "sim":0.9977999926, - "partner":"7nfi" + "sim":0.9987999797, + "partner":"5eza" }, { - "sim":0.9937999845, - "partner":"6g6a" + "sim":0.9771999717, + "partner":"6yaz" }, { - "sim":0.993900001, - "partner":"6g69" + "sim":1.0, + "partner":"7nfn" }, { - "sim":0.9987999797, - "partner":"5eza" + "sim":0.9911000133, + "partner":"6xxz" }, { "sim":0.9987999797, "partner":"6xy0" }, { - "sim":0.9911000133, - "partner":"6xxz" + "sim":0.9970999956, + "partner":"7bau" }, { - "sim":0.9771999717, - "partner":"6yaz" + "sim":1.0, + "partner":"5ezc" }, { "sim":0.9764000177, @@ -241531,17 +242093,29 @@ "sim":0.9955000281, "partner":"6g6c" }, + { + "sim":0.993900001, + "partner":"6g69" + }, { "sim":0.9962999821, "partner":"7nfp" }, + { + "sim":0.9984999895, + "partner":"6g6b" + }, + { + "sim":1.0, + "partner":"6zt1" + }, { "sim":0.994599998, "partner":"6g68" }, { - "sim":0.989199996, - "partner":"7bo9" + "sim":0.9937999845, + "partner":"6g6a" }, { "sim":0.9743999839, @@ -241552,16 +242126,20 @@ "partner":"6g67" }, { - "sim":1.0, - "partner":"7bo8" + "sim":0.9855999947, + "partner":"7boa" }, { "sim":0.9854000211, "partner":"6g66" }, { - "sim":0.9855999947, - "partner":"7boa" + "sim":0.989199996, + "partner":"7bo9" + }, + { + "sim":1.0, + "partner":"7bo8" }, { "sim":0.9808999896, @@ -241587,7 +242165,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"7bav" + "partner":"4pn9" }, "struct_max_sim_natural":[ @@ -241644,85 +242222,85 @@ ], "subtitle":"Crystal structure of pizza6-ayw", "tags":[ - "artificial protein", + "beta propeller", "de novo protein", - "beta propeller" + "artificial protein" ], "keywords":[ - "stability", - "derivatives", - "evolution", - "composed", - "consisting", + "made", + "designed", + "repeats", + "monitor", + "central", "fluorophores", - "confirm", - "pizza6", - "expected", - "maintain", - "studies", - "proteins", - "redshift", - "lack", - "also", - "four", + "fluorescence", "characterized", - "act", - "among", - "designed", - "appears", - "emission", - "tandem", + "observed", + "structures", + "derivative", + "suitable", + "natural", "bionanotechnology", - "mutant", + "trp", + "around", + "first", + "three", + "consisting", + "derivatives", "residues", - "kinetics", - "highly", + "structure", + "comparable", + "among", + "block", + "tool", + "also", + "folding", + "symmetrical", + "could", + "model", + "recently", + "protein", + "buried", "useful", - "difficult", - "purified", - "motif", - "crystal", "six", - "made", + "axis", + "denaturation", + "completely", + "pizza6", + "stability", + "proteins", "clear", - "central", + "kinetics", + "motif", "several", - "observed", - "model", + "act", + "emission", "arranged", - "denaturation", - "comparable", - "symmetrical", - "prove", - "protein", - "structures", - "buried", - "upon", - "identical", - "natural", - "future", + "tandem", "high", - "three", - "block", - "repeats", - "monitor", - "structure", - "derivative", - "suitable", - "recently", - "could", - "fluorescence", - "axis", + "maintain", + "upon", + "appears", + "highly", "building", - "trp", - "first", - "folding", - "around", + "difficult", + "composed", + "identical", + "expected", + "confirm", + "evolution", "repeated", - "completely", + "studies", + "purified", + "crystal", + "mutant", "total", - "tool", - "investigate" + "redshift", + "four", + "future", + "prove", + "investigate", + "lack" ], "release_date":"2018-03-21", "publication":"\"Design of tryptophan-containing mutants of the symmetrical Pizza protein for biophysical studies\", Biochem. Biophys. Res. Commun., 497, 1038-1042", @@ -241775,43 +242353,43 @@ }, { "sim":492.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":492.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":492.0, - "partner":"7zpz" + "partner":"6qse" }, { "sim":492.0, - "partner":"7ov7" + "partner":"6reg" }, { "sim":492.0, - "partner":"6rei" + "partner":"6qsf" }, { "sim":492.0, - "partner":"6qsf" + "partner":"6qsg" }, { "sim":492.0, - "partner":"6reh" + "partner":"6qsh" }, { "sim":492.0, - "partner":"6qsg" + "partner":"6qsd" }, { "sim":492.0, - "partner":"6qsd" + "partner":"7zpz" }, { "sim":492.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":490.0, @@ -241827,15 +242405,15 @@ }, { "sim":486.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":486.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":486.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":486.0, @@ -241859,11 +242437,11 @@ }, { "sim":461.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":461.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":461.0, @@ -241871,7 +242449,7 @@ }, { "sim":461.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":163.0, @@ -241883,11 +242461,11 @@ }, { "sim":162.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":162.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":161.0, @@ -241897,11 +242475,11 @@ "seq_thr_sim_natural":[ { "sim":329.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":329.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":91.0, @@ -241991,7 +242569,7 @@ }, "seq_max_sim_natural":{ "sim":329.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9684000015, @@ -242053,85 +242631,85 @@ ], "subtitle":"Crystal structure of pizza6-syw", "tags":[ - "artificial protein", + "beta propeller", "de novo protein", - "beta propeller" + "artificial protein" ], "keywords":[ - "stability", - "derivatives", - "evolution", - "composed", - "consisting", + "made", + "designed", + "repeats", + "monitor", + "central", "fluorophores", - "confirm", - "pizza6", - "expected", - "maintain", - "studies", - "proteins", - "redshift", - "lack", - "also", - "four", + "fluorescence", "characterized", - "act", - "among", - "designed", - "appears", - "emission", - "tandem", + "observed", + "structures", + "derivative", + "suitable", + "natural", "bionanotechnology", - "mutant", + "trp", + "around", + "first", + "three", + "consisting", + "derivatives", "residues", - "kinetics", - "highly", + "structure", + "comparable", + "among", + "block", + "tool", + "also", + "folding", + "symmetrical", + "could", + "model", + "recently", + "protein", + "buried", "useful", - "difficult", - "purified", - "motif", - "crystal", "six", - "made", + "axis", + "denaturation", + "completely", + "pizza6", + "stability", + "proteins", "clear", - "central", + "kinetics", + "motif", "several", - "observed", - "model", + "act", + "emission", "arranged", - "denaturation", - "comparable", - "symmetrical", - "prove", - "protein", - "structures", - "buried", - "upon", - "identical", - "natural", - "future", + "tandem", "high", - "three", - "block", - "repeats", - "monitor", - "structure", - "derivative", - "suitable", - "recently", - "could", - "fluorescence", - "axis", + "maintain", + "upon", + "appears", + "highly", "building", - "trp", - "first", - "folding", - "around", + "difficult", + "composed", + "identical", + "expected", + "confirm", + "evolution", "repeated", - "completely", + "studies", + "purified", + "crystal", + "mutant", "total", - "tool", - "investigate" + "redshift", + "four", + "future", + "prove", + "investigate", + "lack" ], "release_date":"2018-03-21", "publication":"\"Design of tryptophan-containing mutants of the symmetrical Pizza protein for biophysical studies\", Biochem. Biophys. Res. Commun., 497, 1038-1042", @@ -242168,19 +242746,19 @@ }, { "sim":497.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":497.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":497.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":497.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":497.0, @@ -242188,11 +242766,11 @@ }, { "sim":497.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":497.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":497.0, @@ -242200,7 +242778,7 @@ }, { "sim":497.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":492.0, @@ -242212,15 +242790,15 @@ }, { "sim":492.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":492.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":492.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":492.0, @@ -242264,11 +242842,11 @@ }, { "sim":467.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":467.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":467.0, @@ -242276,7 +242854,7 @@ }, { "sim":467.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":454.0, @@ -242292,11 +242870,11 @@ }, { "sim":164.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":164.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":163.0, @@ -242306,11 +242884,11 @@ "seq_thr_sim_natural":[ { "sim":334.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":334.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":80.0, @@ -242432,7 +243010,7 @@ }, "seq_max_sim_natural":{ "sim":334.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9843000174, @@ -242494,85 +243072,85 @@ ], "subtitle":"Crystal structure of pizza6-sfw", "tags":[ - "artificial protein", + "beta propeller", "de novo protein", - "beta propeller" + "artificial protein" ], "keywords":[ - "stability", - "derivatives", - "evolution", - "composed", - "consisting", + "made", + "designed", + "repeats", + "monitor", + "central", "fluorophores", - "confirm", - "pizza6", - "expected", - "maintain", - "studies", - "proteins", - "redshift", - "lack", - "also", - "four", + "fluorescence", "characterized", - "act", - "among", - "designed", - "appears", - "emission", - "tandem", + "observed", + "structures", + "derivative", + "suitable", + "natural", "bionanotechnology", - "mutant", + "trp", + "around", + "first", + "three", + "consisting", + "derivatives", "residues", - "kinetics", - "highly", + "structure", + "comparable", + "among", + "block", + "tool", + "also", + "folding", + "symmetrical", + "could", + "model", + "recently", + "protein", + "buried", "useful", - "difficult", - "purified", - "motif", - "crystal", "six", - "made", + "axis", + "denaturation", + "completely", + "pizza6", + "stability", + "proteins", "clear", - "central", + "kinetics", + "motif", "several", - "observed", - "model", + "act", + "emission", "arranged", - "denaturation", - "comparable", - "symmetrical", - "prove", - "protein", - "structures", - "buried", - "upon", - "identical", - "natural", - "future", + "tandem", "high", - "three", - "block", - "repeats", - "monitor", - "structure", - "derivative", - "suitable", - "recently", - "could", - "fluorescence", - "axis", + "maintain", + "upon", + "appears", + "highly", "building", - "trp", - "first", - "folding", - "around", + "difficult", + "composed", + "identical", + "expected", + "confirm", + "evolution", "repeated", - "completely", + "studies", + "purified", + "crystal", + "mutant", "total", - "tool", - "investigate" + "redshift", + "four", + "future", + "prove", + "investigate", + "lack" ], "release_date":"2018-03-21", "publication":"\"Design of tryptophan-containing mutants of the symmetrical Pizza protein for biophysical studies\", Biochem. Biophys. Res. Commun., 497, 1038-1042", @@ -242605,19 +243183,19 @@ "seq_thr_sim_designed":[ { "sim":497.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":497.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":497.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":497.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":497.0, @@ -242625,11 +243203,11 @@ }, { "sim":497.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":497.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":497.0, @@ -242637,19 +243215,19 @@ }, { "sim":497.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":492.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":492.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":492.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":492.0, @@ -242693,11 +243271,11 @@ }, { "sim":467.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":467.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":467.0, @@ -242705,7 +243283,7 @@ }, { "sim":467.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":461.0, @@ -242733,11 +243311,11 @@ }, { "sim":164.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":164.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":163.0, @@ -242751,11 +243329,11 @@ "seq_thr_sim_natural":[ { "sim":334.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":334.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":64.0, @@ -242791,11 +243369,11 @@ }, { "sim":53.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":53.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":52.0, @@ -242849,11 +243427,11 @@ ], "seq_max_sim_designed":{ "sim":497.0, - "partner":"6qsh" + "partner":"6rei" }, "seq_max_sim_natural":{ "sim":334.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.962199986, @@ -242939,50 +243517,50 @@ ], "subtitle":"Nmr ensemble of macrocyclic peptidomimetic containing constrained a,a-dialkylated amino acids with potent and selective activity at human melanocortin receptors", "tags":[ - "dialkylated", - "amino acid", - "melanocortin", "de novo protein", - "peptidomimetics" + "amino acid", + "dialkylated", + "peptidomimetics", + "melanocortin" ], "keywords":[ + "modulators", + "finally", + "design", + "constrained", + "development", + "cycle", + "suitable", + "represent", + "macrocyclic", + "puzzle", "derivatives", - "amino", - "dimension", - "study", + "selective", "report", - "unprecedented", + "frame", + "ligands", "culminated", - "rings", - "acids", - "discovery", - "finally", - "melanocortin", - "receptor", "resulting", + "therapeutic", + "study", "selectivity", + "amino", + "adding", + "achieved", + "incorporating", "activity", "system", - "constrained", - "incorporating", - "design", - "selective", + "profile", "modifying", - "modulators", - "frame", - "adding", - "puzzle", - "development", - "represent", - "suitable", - "macrocyclic", "pieces", - "profile", - "ligands", - "achieved", - "novel", - "therapeutic", - "cycle" + "acids", + "discovery", + "rings", + "receptor", + "unprecedented", + "melanocortin", + "dimension", + "novel" ], "release_date":"2018-04-25", "publication":"\"Development of Macrocyclic Peptidomimetics Containing Constrained alpha , alpha-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors\", J. Med. Chem., 61, 4263-4269", @@ -243092,101 +243670,101 @@ ], "subtitle":"Crystal structure of novel repeat protein bric2 fused to darpin d12", "tags":[ - "corrugated repeat", "computational design", "de novo protein", + "corrugated repeat", "novel fold" ], "keywords":[ - "recapitulate", - "reduces", - "architecture", - "low", - "strategy", - "compromising", - "challenge", - "intramolecular", - "target", - "abolishing", - "features", - "sampling", - "priori", - "designing", "therefore", - "structure", - "uniformly", - "however", - "novel", + "three", + "topological", + "strategy", + "protein", + "none", + "extensive", + "handed", + "major", + "two", + "optimal", + "creating", + "previous", + "construction", "achieve", - "starting", - "interfaces", - "without", - "depart", - "proteins", - "employed", + "complex", "enables", - "attempted", "characterized", - "effectively", - "resulting", - "remains", - "highly", - "necessary", + "however", + "abolishing", + "confirming", + "starting", + "efforts", + "priori", + "level", + "control", + "proteins", + "aimed", + "low", + "uniformly", + "architecture", + "modular", + "intramolecular", "far", - "alternating", - "upon", + "highly", + "solenoid", + "features", + "computational", + "profile", + "set", + "designing", + "internally", + "design", + "sampling", + "exists", + "provides", "natural", + "properties", + "platform", + "fold", "complexity", - "three", + "reduces", + "alternating", + "upon", "amount", - "profile", - "form", - "extensive", - "platform", - "properties", - "toward", - "control", - "handedness", - "fragments", + "sequence", "corrugated", - "optimal", - "internally", - "provides", - "design", + "effectively", + "toward", "present", - "existing", - "confirming", "describe", - "sequence", - "introducing", - "known", - "aimed", - "construction", - "efforts", - "directed", - "fold", - "handed", - "modular", - "centered", - "topological", - "two", "folds", - "none", - "creating", - "set", - "exists", - "examples", - "protein", + "handedness", + "form", "superhelical", - "superhelicity", - "previous", - "solenoid", - "complex", + "employed", + "directed", + "introducing", + "centered", + "interfaces", + "recapitulate", + "fragments", + "attempted", "solving", - "computational", - "major", + "remains", + "without", + "structure", + "resulting", + "target", "biophysical", - "level" + "necessary", + "known", + "examples", + "compromising", + "depart", + "superhelicity", + "existing", + "challenge", + "novel" ], "release_date":"2018-09-05", "publication":"\"An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture\", ACS Synth Biol, 7, 2226-2235", @@ -243255,7 +243833,7 @@ }, { "sim":294.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":294.0, @@ -243263,7 +243841,7 @@ }, { "sim":294.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":293.0, @@ -243299,15 +243877,15 @@ }, { "sim":237.0, - "partner":"7b4t" + "partner":"6fpb" }, { "sim":237.0, - "partner":"6fpb" + "partner":"6fpa" }, { "sim":237.0, - "partner":"6fpa" + "partner":"7b4t" }, { "sim":237.0, @@ -243359,47 +243937,47 @@ }, { "sim":225.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":225.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":225.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":225.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":225.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":225.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":225.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":225.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":225.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":225.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":225.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":225.0, @@ -243407,15 +243985,15 @@ }, { "sim":225.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":225.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":225.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":224.0, @@ -243475,11 +244053,11 @@ }, { "sim":205.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":205.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":205.0, @@ -243503,11 +244081,11 @@ }, { "sim":179.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":179.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":177.0, @@ -243515,16 +244093,20 @@ }, { "sim":175.0, - "partner":"4hqd" + "partner":"9glq" }, { "sim":175.0, - "partner":"4o60" + "partner":"4hqd" }, { "sim":175.0, "partner":"4qfv" }, + { + "sim":175.0, + "partner":"4o60" + }, { "sim":174.0, "partner":"8rci" @@ -243641,11 +244223,11 @@ }, { "sim":238.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":238.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":238.0, @@ -243677,11 +244259,11 @@ }, { "sim":232.0, - "partner":"5oyj" + "partner":"2y1l" }, { "sim":232.0, - "partner":"2y1l" + "partner":"5oyj" }, { "sim":231.0, @@ -243719,10 +244301,6 @@ "sim":227.0, "partner":"4hrm" }, - { - "sim":226.0, - "partner":"5eno" - }, { "sim":226.0, "partner":"4dx6" @@ -243791,6 +244369,10 @@ "sim":226.0, "partner":"4dx5" }, + { + "sim":226.0, + "partner":"5eno" + }, { "sim":226.0, "partner":"5mlb" @@ -243901,11 +244483,11 @@ }, { "sim":205.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":205.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":203.0, @@ -243977,11 +244559,11 @@ }, { "sim":159.0, - "partner":"2lch" + "partner":"3u3b" }, { "sim":159.0, - "partner":"3u3b" + "partner":"2lch" }, { "sim":126.0, @@ -244109,20 +244691,16 @@ }, { "sim":100.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":100.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":98.0, "partner":"2l6b" }, - { - "sim":96.0, - "partner":"5vhj" - }, { "sim":96.0, "partner":"5vhh" @@ -244151,6 +244729,10 @@ "sim":96.0, "partner":"5vho" }, + { + "sim":96.0, + "partner":"5vhj" + }, { "sim":96.0, "partner":"5vhp" @@ -244177,15 +244759,15 @@ }, { "sim":96.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":96.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":96.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":96.0, @@ -244509,11 +245091,11 @@ }, { "sim":66.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":66.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":66.0, @@ -244543,10 +245125,6 @@ "sim":64.0, "partner":"5wo6" }, - { - "sim":64.0, - "partner":"5iwr" - }, { "sim":64.0, "partner":"5iwt" @@ -244595,6 +245173,10 @@ "sim":64.0, "partner":"5iwp" }, + { + "sim":64.0, + "partner":"5iwr" + }, { "sim":64.0, "partner":"5wo7" @@ -244629,15 +245211,15 @@ }, { "sim":59.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":59.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":59.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":59.0, @@ -244647,10 +245229,6 @@ "sim":58.0, "partner":"6e2f" }, - { - "sim":58.0, - "partner":"6bo9" - }, { "sim":58.0, "partner":"6boa" @@ -244667,6 +245245,10 @@ "sim":58.0, "partner":"6bo8" }, + { + "sim":58.0, + "partner":"6bo9" + }, { "sim":57.0, "partner":"6emk" @@ -244719,6 +245301,10 @@ "sim":51.0, "partner":"3ljn" }, + { + "sim":51.0, + "partner":"8ycp" + }, { "sim":50.0, "partner":"5ybv" @@ -244806,101 +245392,101 @@ ], "subtitle":"Crystal structure of novel repeat protein bric1", "tags":[ - "corrugated repeat", "computational design", "de novo protein", + "corrugated repeat", "novel fold" ], "keywords":[ - "recapitulate", - "reduces", - "architecture", - "low", - "strategy", - "compromising", - "challenge", - "intramolecular", - "target", - "abolishing", - "features", - "sampling", - "priori", - "designing", "therefore", - "structure", - "uniformly", - "however", - "novel", + "three", + "topological", + "strategy", + "protein", + "none", + "extensive", + "handed", + "major", + "two", + "optimal", + "creating", + "previous", + "construction", "achieve", - "starting", - "interfaces", - "without", - "depart", - "proteins", - "employed", + "complex", "enables", - "attempted", "characterized", - "effectively", - "resulting", - "remains", - "highly", - "necessary", + "however", + "abolishing", + "confirming", + "starting", + "efforts", + "priori", + "level", + "control", + "proteins", + "aimed", + "low", + "uniformly", + "architecture", + "modular", + "intramolecular", "far", - "alternating", - "upon", + "highly", + "solenoid", + "features", + "computational", + "profile", + "set", + "designing", + "internally", + "design", + "sampling", + "exists", + "provides", "natural", + "properties", + "platform", + "fold", "complexity", - "three", + "reduces", + "alternating", + "upon", "amount", - "profile", - "form", - "extensive", - "platform", - "properties", - "toward", - "control", - "handedness", - "fragments", + "sequence", "corrugated", - "optimal", - "internally", - "provides", - "design", + "effectively", + "toward", "present", - "existing", - "confirming", "describe", - "sequence", - "introducing", - "known", - "aimed", - "construction", - "efforts", - "directed", - "fold", - "handed", - "modular", - "centered", - "topological", - "two", "folds", - "none", - "creating", - "set", - "exists", - "examples", - "protein", + "handedness", + "form", "superhelical", - "superhelicity", - "previous", - "solenoid", - "complex", + "employed", + "directed", + "introducing", + "centered", + "interfaces", + "recapitulate", + "fragments", + "attempted", "solving", - "computational", - "major", + "remains", + "without", + "structure", + "resulting", + "target", "biophysical", - "level" + "necessary", + "known", + "examples", + "compromising", + "depart", + "superhelicity", + "existing", + "challenge", + "novel" ], "release_date":"2018-09-05", "publication":"\"An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture\", ACS Synth Biol, 7, 2226-2235", @@ -244937,11 +245523,11 @@ }, { "sim":51.0, - "partner":"8c66" + "partner":"8adx" }, { "sim":51.0, - "partner":"8adx" + "partner":"8c66" }, { "sim":50.0, @@ -245157,10 +245743,6 @@ "sim":54.0, "partner":"4hu4" }, - { - "sim":54.0, - "partner":"4rtl" - }, { "sim":54.0, "partner":"4rtm" @@ -245203,19 +245785,23 @@ }, { "sim":54.0, - "partner":"3nha" + "partner":"4rtl" }, { "sim":54.0, - "partner":"3nhb" + "partner":"3nh6" }, { "sim":54.0, - "partner":"3nh6" + "partner":"3nh9" }, { "sim":54.0, - "partner":"3nh9" + "partner":"3nha" + }, + { + "sim":54.0, + "partner":"3nhb" }, { "sim":54.0, @@ -245247,15 +245833,15 @@ }, { "sim":53.0, - "partner":"3m9a" + "partner":"3m8e" }, { "sim":53.0, - "partner":"3m8e" + "partner":"3m8f" }, { "sim":53.0, - "partner":"3m8f" + "partner":"3m9a" }, { "sim":53.0, @@ -245497,10 +246083,6 @@ "sim":52.0, "partner":"5x3t" }, - { - "sim":52.0, - "partner":"3l1u" - }, { "sim":52.0, "partner":"3l1v" @@ -245517,6 +246099,10 @@ "sim":52.0, "partner":"3esr" }, + { + "sim":52.0, + "partner":"3l1u" + }, { "sim":52.0, "partner":"6d7r" @@ -245549,10 +246135,6 @@ "sim":52.0, "partner":"2va1" }, - { - "sim":52.0, - "partner":"4jyi" - }, { "sim":52.0, "partner":"4dm6" @@ -245573,6 +246155,10 @@ "sim":52.0, "partner":"4jyh" }, + { + "sim":52.0, + "partner":"4jyi" + }, { "sim":52.0, "partner":"4izw" @@ -245613,10 +246199,6 @@ "sim":52.0, "partner":"4xzz" }, - { - "sim":52.0, - "partner":"4d2w" - }, { "sim":52.0, "partner":"4d2p" @@ -245651,12 +246233,16 @@ }, { "sim":52.0, - "partner":"3wcf" + "partner":"4d2w" }, { "sim":52.0, "partner":"3wc9" }, + { + "sim":52.0, + "partner":"3wcf" + }, { "sim":52.0, "partner":"3wcl" @@ -245693,10 +246279,6 @@ "sim":52.0, "partner":"3uq6" }, - { - "sim":52.0, - "partner":"2iua" - }, { "sim":52.0, "partner":"2yrf" @@ -245713,6 +246295,10 @@ "sim":52.0, "partner":"2iu9" }, + { + "sim":52.0, + "partner":"2iua" + }, { "sim":52.0, "partner":"5x06" @@ -245753,10 +246339,6 @@ "sim":52.0, "partner":"5hat" }, - { - "sim":52.0, - "partner":"5hjx" - }, { "sim":52.0, "partner":"5han" @@ -245767,11 +246349,11 @@ }, { "sim":52.0, - "partner":"5o3n" + "partner":"5hjx" }, { "sim":52.0, - "partner":"2cj9" + "partner":"5o3n" }, { "sim":52.0, @@ -245787,15 +246369,11 @@ }, { "sim":52.0, - "partner":"5jjq" - }, - { - "sim":52.0, - "partner":"4ids" + "partner":"2cj9" }, { "sim":52.0, - "partner":"4jdc" + "partner":"5jjq" }, { "sim":52.0, @@ -245813,6 +246391,14 @@ "sim":52.0, "partner":"4ihi" }, + { + "sim":52.0, + "partner":"4ids" + }, + { + "sim":52.0, + "partner":"4jdc" + }, { "sim":51.0, "partner":"2m2f" @@ -245889,10 +246475,6 @@ "sim":51.0, "partner":"3d7j" }, - { - "sim":51.0, - "partner":"3n39" - }, { "sim":51.0, "partner":"3n3a" @@ -245909,6 +246491,10 @@ "sim":51.0, "partner":"4ndw" }, + { + "sim":51.0, + "partner":"3n39" + }, { "sim":51.0, "partner":"4pdb" @@ -245983,11 +246569,11 @@ }, { "sim":51.0, - "partner":"2fz4" + "partner":"3x21" }, { "sim":51.0, - "partner":"3x21" + "partner":"2fz4" }, { "sim":51.0, @@ -246059,15 +246645,15 @@ }, { "sim":51.0, - "partner":"1zw3" + "partner":"1zvz" }, { "sim":51.0, - "partner":"1zvz" + "partner":"1zw2" }, { "sim":51.0, - "partner":"1zw2" + "partner":"1zw3" }, { "sim":51.0, @@ -246161,10 +246747,6 @@ "sim":51.0, "partner":"5uto" }, - { - "sim":51.0, - "partner":"3aio" - }, { "sim":51.0, "partner":"3aik" @@ -246181,6 +246763,10 @@ "sim":51.0, "partner":"3ain" }, + { + "sim":51.0, + "partner":"3aio" + }, { "sim":51.0, "partner":"5fd4" @@ -246199,19 +246785,19 @@ }, { "sim":51.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":51.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":51.0, - "partner":"3tm8" + "partner":"3tmc" }, { "sim":51.0, - "partner":"3tmb" + "partner":"3tmd" }, { "sim":51.0, @@ -246245,14 +246831,6 @@ "sim":51.0, "partner":"2f9y" }, - { - "sim":51.0, - "partner":"4h2w" - }, - { - "sim":51.0, - "partner":"3mey" - }, { "sim":51.0, "partner":"4h2x" @@ -246289,6 +246867,14 @@ "sim":51.0, "partner":"4h2v" }, + { + "sim":51.0, + "partner":"4h2w" + }, + { + "sim":51.0, + "partner":"3mey" + }, { "sim":51.0, "partner":"4rhi" @@ -246503,19 +247089,19 @@ }, { "sim":51.0, - "partner":"4bvq" + "partner":"4bvs" }, { "sim":51.0, - "partner":"4bvr" + "partner":"4bvt" }, { "sim":51.0, - "partner":"4bvs" + "partner":"4bvq" }, { "sim":51.0, - "partner":"4bvt" + "partner":"4bvr" }, { "sim":51.0, @@ -246553,10 +247139,6 @@ "sim":51.0, "partner":"4ov9" }, - { - "sim":51.0, - "partner":"4euh" - }, { "sim":51.0, "partner":"4eue" @@ -246567,15 +247149,15 @@ }, { "sim":51.0, - "partner":"5u22" + "partner":"4euh" }, { "sim":51.0, - "partner":"2wio" + "partner":"5u22" }, { "sim":51.0, - "partner":"4q6q" + "partner":"2wio" }, { "sim":51.0, @@ -246595,12 +247177,16 @@ }, { "sim":51.0, - "partner":"3amu" + "partner":"4q6q" }, { "sim":51.0, "partner":"3amt" }, + { + "sim":51.0, + "partner":"3amu" + }, { "sim":51.0, "partner":"8vwk" @@ -246617,10 +247203,6 @@ "sim":51.0, "partner":"4e3r" }, - { - "sim":51.0, - "partner":"5koz" - }, { "sim":51.0, "partner":"5hjy" @@ -246633,6 +247215,10 @@ "sim":51.0, "partner":"4lf1" }, + { + "sim":51.0, + "partner":"5koz" + }, { "sim":51.0, "partner":"4lf2" @@ -246695,11 +247281,11 @@ }, { "sim":51.0, - "partner":"4gyk" + "partner":"4gyj" }, { "sim":51.0, - "partner":"4gyj" + "partner":"4gyk" }, { "sim":51.0, @@ -246807,11 +247393,11 @@ }, { "sim":50.0, - "partner":"4o8t" + "partner":"4o8l" }, { "sim":50.0, - "partner":"4o8l" + "partner":"4o8t" }, { "sim":50.0, @@ -246829,10 +247415,6 @@ "sim":50.0, "partner":"5w10" }, - { - "sim":50.0, - "partner":"5wg9" - }, { "sim":50.0, "partner":"5wap" @@ -246935,11 +247517,11 @@ }, { "sim":50.0, - "partner":"2qh1" + "partner":"5wg9" }, { "sim":50.0, - "partner":"5l9k" + "partner":"2qh1" }, { "sim":50.0, @@ -246953,6 +247535,10 @@ "sim":50.0, "partner":"5lau" }, + { + "sim":50.0, + "partner":"5l9k" + }, { "sim":50.0, "partner":"3k3k" @@ -246963,11 +247549,11 @@ }, { "sim":50.0, - "partner":"3kwe" + "partner":"3kwd" }, { "sim":50.0, - "partner":"3kwd" + "partner":"3kwe" }, { "sim":50.0, @@ -247011,23 +247597,23 @@ }, { "sim":50.0, - "partner":"4njh" + "partner":"4njj" }, { "sim":50.0, - "partner":"4nji" + "partner":"4njk" }, { "sim":50.0, - "partner":"4njj" + "partner":"4njg" }, { "sim":50.0, - "partner":"4njk" + "partner":"4njh" }, { "sim":50.0, - "partner":"4njg" + "partner":"4nji" }, { "sim":50.0, @@ -247047,15 +247633,15 @@ }, { "sim":50.0, - "partner":"5cvd" + "partner":"5cve" }, { "sim":50.0, - "partner":"5cve" + "partner":"3qu4" }, { "sim":50.0, - "partner":"3qu4" + "partner":"5cvd" }, { "sim":50.0, @@ -247197,10 +247783,6 @@ "sim":50.0, "partner":"6djt" }, - { - "sim":50.0, - "partner":"3auz" - }, { "sim":50.0, "partner":"2obj" @@ -247217,6 +247799,10 @@ "sim":50.0, "partner":"3bgq" }, + { + "sim":50.0, + "partner":"3auz" + }, { "sim":50.0, "partner":"3x27" @@ -247327,7 +247913,7 @@ }, { "sim":50.0, - "partner":"2plj" + "partner":"8s53" }, { "sim":50.0, @@ -247337,6 +247923,10 @@ "sim":50.0, "partner":"1jk0" }, + { + "sim":50.0, + "partner":"2plj" + }, { "sim":50.0, "partner":"4rnf" @@ -247385,10 +247975,6 @@ "sim":50.0, "partner":"2w5f" }, - { - "sim":50.0, - "partner":"5wm2" - }, { "sim":50.0, "partner":"5wm3" @@ -247409,6 +247995,10 @@ "sim":50.0, "partner":"5wm7" }, + { + "sim":50.0, + "partner":"5wm2" + }, { "sim":50.0, "partner":"4oxi" @@ -247520,110 +248110,110 @@ ], "subtitle":"Crystal structure of anti-mtfp1 darpin 1238_e11", "tags":[ - "darpin", - "protein binder", "de novo protein", - "designed ankyrin repeat proteins" + "designed ankyrin repeat proteins", + "protein binder", + "darpin" ], "keywords":[ - "utilization", - "many", - "monomeric", - "fulfil", - "studies", - "manipulation", - "genetic", - "use", - "developmental", - "fusing", - "expressed", - "mtfp1", - "designed", - "generated", - "example", - "functionalized", - "improved", - "methods", - "target", - "based", - "order", - "versatile", - "repeat", "affinity", - "direct", + "repeat", + "manipulations", + "methods", + "localize", + "extracellular", + "fluorescent", + "helpful", + "manners", + "reagents", + "protein", + "cells", + "domains", + "utilization", + "nuclear", "isolated", - "acute", - "phenotypes", - "proteins", - "employed", + "modify", + "corresponding", "rab", - "cell", + "biological", + "milieu", + "specific", + "endogenous", + "functions", + "last", + "proteins", + "several", + "use", + "ankyrin", "modulate", + "enzymatically", "compartment", "small", - "used", - "binders", - "nuclear", - "anymore", - "production", - "helpful", - "living", - "mcherry", - "corresponding", + "cultured", + "created", + "manipulation", "future", - "biology", "organisms", - "milieu", - "created", - "previously", - "fluorescent", - "generation", - "years", + "mcherry", "regulate", - "resulted", - "report", - "reagents", - "darpins", "1", - "gfp", - "tags", - "approaches", - "functions", - "degrade", - "specific", - "trap", + "direct", + "intracellular", + "living", + "diverse", + "binders", + "used", + "biology", + "acute", + "different", + "phenotypes", "delocalize", - "localize", - "several", + "tagged", + "also", + "cell", "teal", + "improved", + "resulted", + "validated", + "types", + "versatile", + "developmental", + "whereas", + "analyses", + "darpins", + "production", + "designed", + "employed", + "example", + "order", + "generation", + "many", "rather", - "manners", - "extracellular", - "biological", - "endogenous", - "cells", - "cultured", - "manipulate", - "diverse", + "approaches", + "expressed", + "previously", + "degrade", + "based", + "gfp", + "monomeric", + "tags", "might", - "manipulations", - "analyses", - "also", - "intracellular", - "tagged", - "enzymatically", + "report", + "target", + "fulfil", + "trap", + "regular", "enable", - "last", + "mtfp1", + "years", "proven", - "different", - "ankyrin", - "validated", - "modify", - "domains", - "protein", - "regular", - "types", - "whereas" + "manipulate", + "generated", + "genetic", + "anymore", + "studies", + "functionalized", + "fusing" ], "release_date":"2018-10-03", "publication":"\"DARPins recognizing mTFP1 as novel reagents forin vitroandin vivoprotein manipulations\", Biol Open, 7", @@ -247696,19 +248286,19 @@ }, { "sim":279.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":279.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":279.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":279.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":279.0, @@ -247716,35 +248306,35 @@ }, { "sim":279.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":279.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":279.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":279.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":279.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":279.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":279.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":279.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":278.0, @@ -247760,11 +248350,11 @@ }, { "sim":277.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":277.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":276.0, @@ -247824,11 +248414,11 @@ }, { "sim":267.0, - "partner":"8a1a" + "partner":"8a19" }, { "sim":267.0, - "partner":"8a19" + "partner":"8a1a" }, { "sim":266.0, @@ -247840,7 +248430,7 @@ }, { "sim":264.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":264.0, @@ -247848,7 +248438,7 @@ }, { "sim":264.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":263.0, @@ -247932,11 +248522,11 @@ }, { "sim":234.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":234.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":234.0, @@ -247948,11 +248538,11 @@ }, { "sim":218.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":218.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":210.0, @@ -247964,11 +248554,11 @@ }, { "sim":206.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":206.0, - "partner":"4qfv" + "partner":"4o60" }, { "sim":199.0, @@ -247994,6 +248584,10 @@ "sim":184.0, "partner":"4gmr" }, + { + "sim":183.0, + "partner":"9glq" + }, { "sim":181.0, "partner":"4gpm" @@ -248076,10 +248670,6 @@ "sim":282.0, "partner":"3nog" }, - { - "sim":280.0, - "partner":"5eno" - }, { "sim":280.0, "partner":"4dx6" @@ -248154,15 +248744,15 @@ }, { "sim":280.0, - "partner":"5lel" + "partner":"5eno" }, { - "sim":279.0, - "partner":"5oov" + "sim":280.0, + "partner":"5lel" }, { "sim":279.0, - "partner":"5oyj" + "partner":"5oov" }, { "sim":279.0, @@ -248184,6 +248774,10 @@ "sim":279.0, "partner":"5nm5" }, + { + "sim":279.0, + "partner":"5oyj" + }, { "sim":278.0, "partner":"3noc" @@ -248222,11 +248816,11 @@ }, { "sim":275.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":275.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":275.0, @@ -248358,11 +248952,11 @@ }, { "sim":233.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":233.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":231.0, @@ -248520,10 +249114,6 @@ "sim":108.0, "partner":"2l6b" }, - { - "sim":106.0, - "partner":"5vhj" - }, { "sim":106.0, "partner":"5vhh" @@ -248552,6 +249142,10 @@ "sim":106.0, "partner":"5vho" }, + { + "sim":106.0, + "partner":"5vhj" + }, { "sim":106.0, "partner":"5vhp" @@ -248578,15 +249172,15 @@ }, { "sim":106.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":106.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":106.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":106.0, @@ -248610,11 +249204,11 @@ }, { "sim":101.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":101.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":100.0, @@ -248674,15 +249268,15 @@ }, { "sim":92.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":92.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":92.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":91.0, @@ -248958,15 +249552,15 @@ }, { "sim":71.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":71.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":71.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":70.0, @@ -248976,10 +249570,6 @@ "sim":70.0, "partner":"5wo6" }, - { - "sim":70.0, - "partner":"5iwr" - }, { "sim":70.0, "partner":"5iwt" @@ -249028,6 +249618,10 @@ "sim":70.0, "partner":"5iwp" }, + { + "sim":70.0, + "partner":"5iwr" + }, { "sim":70.0, "partner":"5wo7" @@ -249064,10 +249658,6 @@ "sim":63.0, "partner":"6e2f" }, - { - "sim":63.0, - "partner":"6bo9" - }, { "sim":63.0, "partner":"6boa" @@ -249084,6 +249674,10 @@ "sim":63.0, "partner":"6bo8" }, + { + "sim":63.0, + "partner":"6bo9" + }, { "sim":62.0, "partner":"3deo" @@ -249166,15 +249760,15 @@ }, { "sim":53.0, - "partner":"6dvz" + "partner":"6dvw" }, { "sim":53.0, - "partner":"6dvw" + "partner":"6dvy" }, { "sim":53.0, - "partner":"6dvy" + "partner":"6dvz" }, { "sim":51.0, @@ -249401,110 +249995,110 @@ ], "subtitle":"Crystal structure of anti-mtfp1 darpin 1238_g01 in space group p212121", "tags":[ - "darpin", - "protein binder", "de novo protein", - "designed ankyrin repeat proteins" + "designed ankyrin repeat proteins", + "protein binder", + "darpin" ], "keywords":[ - "utilization", - "many", - "monomeric", - "fulfil", - "studies", - "manipulation", - "genetic", - "use", - "developmental", - "fusing", - "expressed", - "mtfp1", - "designed", - "generated", - "example", - "functionalized", - "improved", - "methods", - "target", - "based", - "order", - "versatile", - "repeat", "affinity", - "direct", + "repeat", + "manipulations", + "methods", + "localize", + "extracellular", + "fluorescent", + "helpful", + "manners", + "reagents", + "protein", + "cells", + "domains", + "utilization", + "nuclear", "isolated", - "acute", - "phenotypes", - "proteins", - "employed", + "modify", + "corresponding", "rab", - "cell", + "biological", + "milieu", + "specific", + "endogenous", + "functions", + "last", + "proteins", + "several", + "use", + "ankyrin", "modulate", + "enzymatically", "compartment", "small", - "used", - "binders", - "nuclear", - "anymore", - "production", - "helpful", - "living", - "mcherry", - "corresponding", + "cultured", + "created", + "manipulation", "future", - "biology", "organisms", - "milieu", - "created", - "previously", - "fluorescent", - "generation", - "years", + "mcherry", "regulate", - "resulted", - "report", - "reagents", - "darpins", "1", - "gfp", - "tags", - "approaches", - "functions", - "degrade", - "specific", - "trap", + "direct", + "intracellular", + "living", + "diverse", + "binders", + "used", + "biology", + "acute", + "different", + "phenotypes", "delocalize", - "localize", - "several", + "tagged", + "also", + "cell", "teal", + "improved", + "resulted", + "validated", + "types", + "versatile", + "developmental", + "whereas", + "analyses", + "darpins", + "production", + "designed", + "employed", + "example", + "order", + "generation", + "many", "rather", - "manners", - "extracellular", - "biological", - "endogenous", - "cells", - "cultured", - "manipulate", - "diverse", + "approaches", + "expressed", + "previously", + "degrade", + "based", + "gfp", + "monomeric", + "tags", "might", - "manipulations", - "analyses", - "also", - "intracellular", - "tagged", - "enzymatically", + "report", + "target", + "fulfil", + "trap", + "regular", "enable", - "last", + "mtfp1", + "years", "proven", - "different", - "ankyrin", - "validated", - "modify", - "domains", - "protein", - "regular", - "types", - "whereas" + "manipulate", + "generated", + "genetic", + "anymore", + "studies", + "functionalized", + "fusing" ], "release_date":"2018-10-03", "publication":"\"DARPins recognizing mTFP1 as novel reagents forin vitroandin vivoprotein manipulations\", Biol Open, 7", @@ -249609,11 +250203,11 @@ }, { "sim":261.0, - "partner":"7dnf" + "partner":"5knh" }, { "sim":261.0, - "partner":"5knh" + "partner":"7dnf" }, { "sim":261.0, @@ -249633,47 +250227,47 @@ }, { "sim":256.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":256.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":256.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":256.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":256.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":256.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":256.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":256.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":256.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":256.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":256.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":256.0, @@ -249681,15 +250275,15 @@ }, { "sim":256.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":256.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":256.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":256.0, @@ -249769,7 +250363,7 @@ }, { "sim":239.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":239.0, @@ -249777,7 +250371,7 @@ }, { "sim":239.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":236.0, @@ -249805,11 +250399,11 @@ }, { "sim":232.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":232.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":232.0, @@ -249817,11 +250411,11 @@ }, { "sim":218.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":218.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":216.0, @@ -249867,6 +250461,10 @@ "sim":186.0, "partner":"4gmr" }, + { + "sim":185.0, + "partner":"9glq" + }, { "sim":185.0, "partner":"4gpm" @@ -249915,11 +250513,11 @@ }, { "sim":278.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":278.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":278.0, @@ -250049,10 +250647,6 @@ "sim":256.0, "partner":"6bbn" }, - { - "sim":256.0, - "partner":"5eno" - }, { "sim":256.0, "partner":"4dx6" @@ -250145,6 +250739,10 @@ "sim":256.0, "partner":"4dx5" }, + { + "sim":256.0, + "partner":"5eno" + }, { "sim":256.0, "partner":"5aq9" @@ -250235,11 +250833,11 @@ }, { "sim":230.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":230.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":223.0, @@ -250359,11 +250957,11 @@ }, { "sim":103.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":103.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":102.0, @@ -250391,15 +250989,15 @@ }, { "sim":97.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":97.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":97.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":97.0, @@ -250653,10 +251251,6 @@ "sim":70.0, "partner":"5wo6" }, - { - "sim":70.0, - "partner":"5iwr" - }, { "sim":70.0, "partner":"5iwt" @@ -250705,6 +251299,10 @@ "sim":70.0, "partner":"5iwp" }, + { + "sim":70.0, + "partner":"5iwr" + }, { "sim":70.0, "partner":"5wo7" @@ -250733,10 +251331,6 @@ "sim":63.0, "partner":"6e2f" }, - { - "sim":63.0, - "partner":"6bo9" - }, { "sim":63.0, "partner":"6boa" @@ -250753,6 +251347,10 @@ "sim":63.0, "partner":"6bo8" }, + { + "sim":63.0, + "partner":"6bo9" + }, { "sim":58.0, "partner":"3deo" @@ -250986,110 +251584,110 @@ ], "subtitle":"Crystal structure of anti-mtfp1 darpin 1238_g01 in space group i4", "tags":[ - "darpin", - "protein binder", + "designed ankyrin repeat protein", "de novo protein", - "designed ankyrin repeat protein" + "protein binder", + "darpin" ], "keywords":[ - "utilization", - "many", - "monomeric", - "fulfil", - "studies", - "manipulation", - "genetic", - "use", - "developmental", - "fusing", - "expressed", - "mtfp1", - "designed", - "generated", - "example", - "functionalized", - "improved", - "methods", - "target", - "based", - "order", - "versatile", - "repeat", "affinity", - "direct", + "repeat", + "manipulations", + "methods", + "localize", + "extracellular", + "fluorescent", + "helpful", + "manners", + "reagents", + "protein", + "cells", + "domains", + "utilization", + "nuclear", "isolated", - "acute", - "phenotypes", - "proteins", - "employed", + "modify", + "corresponding", "rab", - "cell", + "biological", + "milieu", + "specific", + "endogenous", + "functions", + "last", + "proteins", + "several", + "use", + "ankyrin", "modulate", + "enzymatically", "compartment", "small", - "used", - "binders", - "nuclear", - "anymore", - "production", - "helpful", - "living", - "mcherry", - "corresponding", + "cultured", + "created", + "manipulation", "future", - "biology", "organisms", - "milieu", - "created", - "previously", - "fluorescent", - "generation", - "years", + "mcherry", "regulate", - "resulted", - "report", - "reagents", - "darpins", "1", - "gfp", - "tags", - "approaches", - "functions", - "degrade", - "specific", - "trap", + "direct", + "intracellular", + "living", + "diverse", + "binders", + "used", + "biology", + "acute", + "different", + "phenotypes", "delocalize", - "localize", - "several", + "tagged", + "also", + "cell", "teal", + "improved", + "resulted", + "validated", + "types", + "versatile", + "developmental", + "whereas", + "analyses", + "darpins", + "production", + "designed", + "employed", + "example", + "order", + "generation", + "many", "rather", - "manners", - "extracellular", - "biological", - "endogenous", - "cells", - "cultured", - "manipulate", - "diverse", + "approaches", + "expressed", + "previously", + "degrade", + "based", + "gfp", + "monomeric", + "tags", "might", - "manipulations", - "analyses", - "also", - "intracellular", - "tagged", - "enzymatically", + "report", + "target", + "fulfil", + "trap", + "regular", "enable", - "last", + "mtfp1", + "years", "proven", - "different", - "ankyrin", - "validated", - "modify", - "domains", - "protein", - "regular", - "types", - "whereas" + "manipulate", + "generated", + "genetic", + "anymore", + "studies", + "functionalized", + "fusing" ], "release_date":"2018-10-03", "publication":"\"DARPins recognizing mTFP1 as novel reagents forin vitroandin vivoprotein manipulations\", Biol Open, 7", @@ -251194,11 +251792,11 @@ }, { "sim":261.0, - "partner":"7dnf" + "partner":"5knh" }, { "sim":261.0, - "partner":"5knh" + "partner":"7dnf" }, { "sim":261.0, @@ -251218,47 +251816,47 @@ }, { "sim":256.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":256.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":256.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":256.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":256.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":256.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":256.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":256.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":256.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":256.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":256.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":256.0, @@ -251266,15 +251864,15 @@ }, { "sim":256.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":256.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":256.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":256.0, @@ -251354,7 +251952,7 @@ }, { "sim":239.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":239.0, @@ -251362,7 +251960,7 @@ }, { "sim":239.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":236.0, @@ -251390,11 +251988,11 @@ }, { "sim":232.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":232.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":232.0, @@ -251402,11 +252000,11 @@ }, { "sim":218.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":218.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":216.0, @@ -251452,6 +252050,10 @@ "sim":186.0, "partner":"4gmr" }, + { + "sim":185.0, + "partner":"9glq" + }, { "sim":185.0, "partner":"4gpm" @@ -251500,11 +252102,11 @@ }, { "sim":278.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":278.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":278.0, @@ -251634,10 +252236,6 @@ "sim":256.0, "partner":"6bbn" }, - { - "sim":256.0, - "partner":"5eno" - }, { "sim":256.0, "partner":"4dx6" @@ -251730,6 +252328,10 @@ "sim":256.0, "partner":"4dx5" }, + { + "sim":256.0, + "partner":"5eno" + }, { "sim":256.0, "partner":"5aq9" @@ -251820,11 +252422,11 @@ }, { "sim":230.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":230.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":223.0, @@ -251944,11 +252546,11 @@ }, { "sim":103.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":103.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":102.0, @@ -251976,15 +252578,15 @@ }, { "sim":97.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":97.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":97.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":97.0, @@ -252238,10 +252840,6 @@ "sim":70.0, "partner":"5wo6" }, - { - "sim":70.0, - "partner":"5iwr" - }, { "sim":70.0, "partner":"5iwt" @@ -252290,6 +252888,10 @@ "sim":70.0, "partner":"5iwp" }, + { + "sim":70.0, + "partner":"5iwr" + }, { "sim":70.0, "partner":"5wo7" @@ -252318,10 +252920,6 @@ "sim":63.0, "partner":"6e2f" }, - { - "sim":63.0, - "partner":"6bo9" - }, { "sim":63.0, "partner":"6boa" @@ -252338,6 +252936,10 @@ "sim":63.0, "partner":"6bo8" }, + { + "sim":63.0, + "partner":"6bo9" + }, { "sim":58.0, "partner":"3deo" @@ -252615,79 +253217,79 @@ ], "subtitle":"Crystal structure of a parallel six-helix coiled coil cc-type2-vv", "tags":[ - "synthetic construct", - "alpha-helical bundle", - "de novo protein", "coiled coil", - "de novo" + "de novo", + "de novo protein", + "alpha-helical bundle", + "synthetic construct" ], "keywords":[ - "maximise", - "without", - "structural", - "reported", - "chains", + "designed", + "form", + "c", + "central", + "symmetry", + "design", + "cavities", "one", - "channels", + "hydrophobic", "another", - "helices", + "water", + "structural", + "show", + "hallmark", + "classes", + "lining", + "interest", + "structures", + "lumen", + "natural", + "maintained", + "around", + "side", + "surprising", "accessible", - "placement", - "cc", - "assemblies", + "assembly", + "aliphatic", + "residues", + "otherwise", "n", - "functionalised", - "ccs", - "barrels", "extended", + "without", + "hitherto", + "placement", + "dihedral", "accessed", - "nonetheless", - "adjust", - "designed", - "unobserved", + "ccs", + "folding", + "strategic", "subset", - "interest", + "cyclic", "surfaces", - "aliphatic", - "residues", - "maintained", - "strategic", - "nature", - "leading", - "classes", - "lining", - "central", - "hallmark", - "increasingly", "drive", - "show", - "lumen", - "design", - "wrap", - "structures", + "give", "protein", + "wrap", "buried", + "nature", "given", - "hydrophobic", - "natural", - "symmetry", - "dihedral", - "c", - "cavities", - "assembly", - "water", - "give", - "form", - "hitherto", - "side", - "folding", - "around", - "otherwise", "packing", - "cyclic", - "surprising", - "five", - "collapse" + "leading", + "cc", + "adjust", + "reported", + "channels", + "increasingly", + "nonetheless", + "helices", + "functionalised", + "assemblies", + "chains", + "collapse", + "unobserved", + "maximise", + "barrels", + "five" ], "release_date":"2018-10-17", "publication":"\"Maintaining and breaking symmetry in homomeric coiled-coil assemblies\", Nat Commun, 9, 4132-4132", @@ -252844,10 +253446,6 @@ "sim":0.9681000113, "partner":"7nfh" }, - { - "sim":0.9521999955, - "partner":"8b15" - }, { "sim":0.9980999827, "partner":"5ez9" @@ -252903,6 +253501,10 @@ { "sim":0.972299993, "partner":"7bau" + }, + { + "sim":0.9521999955, + "partner":"8b15" } ], "struct_thr_sim_natural":[ @@ -252916,7 +253518,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"4pna" + "partner":"5ez8" }, "struct_max_sim_natural":[ @@ -252981,79 +253583,79 @@ ], "subtitle":"Crystal structure of a parallel seven-helix coiled coil cc-type2-iv", "tags":[ - "synthetic construct", - "alpha-helical bundle", - "de novo protein", "coiled coil", - "de novo" + "de novo", + "de novo protein", + "alpha-helical bundle", + "synthetic construct" ], "keywords":[ - "maximise", - "without", - "structural", - "reported", - "chains", + "designed", + "form", + "c", + "central", + "symmetry", + "design", + "cavities", "one", - "channels", + "hydrophobic", "another", - "helices", + "water", + "structural", + "show", + "hallmark", + "classes", + "lining", + "interest", + "structures", + "lumen", + "natural", + "maintained", + "around", + "side", + "surprising", "accessible", - "placement", - "cc", - "assemblies", + "assembly", + "aliphatic", + "residues", + "otherwise", "n", - "functionalised", - "ccs", - "barrels", "extended", + "without", + "hitherto", + "placement", + "dihedral", "accessed", - "nonetheless", - "adjust", - "designed", - "unobserved", + "ccs", + "folding", + "strategic", "subset", - "interest", + "cyclic", "surfaces", - "aliphatic", - "residues", - "maintained", - "strategic", - "nature", - "leading", - "classes", - "lining", - "central", - "hallmark", - "increasingly", "drive", - "show", - "lumen", - "design", - "wrap", - "structures", + "give", "protein", + "wrap", "buried", + "nature", "given", - "hydrophobic", - "natural", - "symmetry", - "dihedral", - "c", - "cavities", - "assembly", - "water", - "give", - "form", - "hitherto", - "side", - "folding", - "around", - "otherwise", "packing", - "cyclic", - "surprising", - "five", - "collapse" + "leading", + "cc", + "adjust", + "reported", + "channels", + "increasingly", + "nonetheless", + "helices", + "functionalised", + "assemblies", + "chains", + "collapse", + "unobserved", + "maximise", + "barrels", + "five" ], "release_date":"2018-10-17", "publication":"\"Maintaining and breaking symmetry in homomeric coiled-coil assemblies\", Nat Commun, 9, 4132-4132", @@ -253319,79 +253921,79 @@ ], "subtitle":"Crystal structure of a parallel eight-helix coiled coil cc-type2-ii", "tags":[ - "synthetic construct", - "alpha-helical bundle", - "de novo protein", "coiled coil", - "de novo" + "de novo", + "de novo protein", + "alpha-helical bundle", + "synthetic construct" ], "keywords":[ - "maximise", - "without", - "structural", - "reported", - "chains", + "designed", + "form", + "c", + "central", + "symmetry", + "design", + "cavities", "one", - "channels", + "hydrophobic", "another", - "helices", + "water", + "structural", + "show", + "hallmark", + "classes", + "lining", + "interest", + "structures", + "lumen", + "natural", + "maintained", + "around", + "side", + "surprising", "accessible", - "placement", - "cc", - "assemblies", + "assembly", + "aliphatic", + "residues", + "otherwise", "n", - "functionalised", - "ccs", - "barrels", "extended", + "without", + "hitherto", + "placement", + "dihedral", "accessed", - "nonetheless", - "adjust", - "designed", - "unobserved", + "ccs", + "folding", + "strategic", "subset", - "interest", + "cyclic", "surfaces", - "aliphatic", - "residues", - "maintained", - "strategic", - "nature", - "leading", - "classes", - "lining", - "central", - "hallmark", - "increasingly", "drive", - "show", - "lumen", - "design", - "wrap", - "structures", + "give", "protein", + "wrap", "buried", + "nature", "given", - "hydrophobic", - "natural", - "symmetry", - "dihedral", - "c", - "cavities", - "assembly", - "water", - "give", - "form", - "hitherto", - "side", - "folding", - "around", - "otherwise", "packing", - "cyclic", - "surprising", - "five", - "collapse" + "leading", + "cc", + "adjust", + "reported", + "channels", + "increasingly", + "nonetheless", + "helices", + "functionalised", + "assemblies", + "chains", + "collapse", + "unobserved", + "maximise", + "barrels", + "five" ], "release_date":"2018-10-17", "publication":"\"Maintaining and breaking symmetry in homomeric coiled-coil assemblies\", Nat Commun, 9, 4132-4132", @@ -253476,14 +254078,6 @@ "sim":1.0, "partner":"6g69" }, - { - "sim":1.0, - "partner":"6g6c" - }, - { - "sim":1.0, - "partner":"6g6g" - }, { "sim":1.0, "partner":"6xy1" @@ -253492,18 +254086,10 @@ "sim":1.0, "partner":"7baw" }, - { - "sim":1.0, - "partner":"8b16" - }, { "sim":0.9575999975, "partner":"7nfk" }, - { - "sim":0.9857000113, - "partner":"4pn9" - }, { "sim":0.9875000119, "partner":"6g6a" @@ -253512,22 +254098,34 @@ "sim":0.9934999943, "partner":"6g6b" }, + { + "sim":1.0, + "partner":"6g6c" + }, { "sim":0.9930999875, "partner":"6g6f" }, { - "sim":0.9944000244, - "partner":"6yb2" + "sim":1.0, + "partner":"6g6g" }, { "sim":0.9794999957, "partner":"7nfo" }, + { + "sim":1.0, + "partner":"8b16" + }, { "sim":0.9564999938, "partner":"8a09" }, + { + "sim":0.9857000113, + "partner":"4pn9" + }, { "sim":0.9775999784, "partner":"6eiz" @@ -253536,6 +254134,10 @@ "sim":0.9908999801, "partner":"6g6d" }, + { + "sim":0.9944000244, + "partner":"6yb2" + }, { "sim":0.9865000248, "partner":"7bat" @@ -253544,10 +254146,6 @@ "sim":1.0, "partner":"7nfg" }, - { - "sim":0.9711999893, - "partner":"7nfh" - }, { "sim":0.9523000121, "partner":"8b15" @@ -253564,6 +254162,10 @@ "sim":1.0, "partner":"5ezc" }, + { + "sim":0.9711999893, + "partner":"7nfh" + }, { "sim":1.0, "partner":"7nfn" @@ -253588,10 +254190,6 @@ "sim":0.9991000295, "partner":"7bav" }, - { - "sim":0.9975000024, - "partner":"7bo9" - }, { "sim":0.9955000281, "partner":"7boa" @@ -253604,6 +254202,10 @@ "sim":0.9979000092, "partner":"7bo8" }, + { + "sim":0.9975000024, + "partner":"7bo9" + }, { "sim":0.9715999961, "partner":"6yb0" @@ -253685,79 +254287,79 @@ ], "subtitle":"Crystal structure of a parallel six-helix coiled coil cc-type2-il-sg", "tags":[ - "synthetic construct", - "alpha-helical bundle", - "de novo protein", "coiled coil", - "de novo" + "de novo", + "de novo protein", + "alpha-helical bundle", + "synthetic construct" ], "keywords":[ - "maximise", - "without", - "structural", - "reported", - "chains", + "designed", + "form", + "c", + "central", + "symmetry", + "design", + "cavities", "one", - "channels", + "hydrophobic", "another", - "helices", + "water", + "structural", + "show", + "hallmark", + "classes", + "lining", + "interest", + "structures", + "lumen", + "natural", + "maintained", + "around", + "side", + "surprising", "accessible", - "placement", - "cc", - "assemblies", + "assembly", + "aliphatic", + "residues", + "otherwise", "n", - "functionalised", - "ccs", - "barrels", "extended", + "without", + "hitherto", + "placement", + "dihedral", "accessed", - "nonetheless", - "adjust", - "designed", - "unobserved", + "ccs", + "folding", + "strategic", "subset", - "interest", + "cyclic", "surfaces", - "aliphatic", - "residues", - "maintained", - "strategic", - "nature", - "leading", - "classes", - "lining", - "central", - "hallmark", - "increasingly", "drive", - "show", - "lumen", - "design", - "wrap", - "structures", + "give", "protein", + "wrap", "buried", + "nature", "given", - "hydrophobic", - "natural", - "symmetry", - "dihedral", - "c", - "cavities", - "assembly", - "water", - "give", - "form", - "hitherto", - "side", - "folding", - "around", - "otherwise", "packing", - "cyclic", - "surprising", - "five", - "collapse" + "leading", + "cc", + "adjust", + "reported", + "channels", + "increasingly", + "nonetheless", + "helices", + "functionalised", + "assemblies", + "chains", + "collapse", + "unobserved", + "maximise", + "barrels", + "five" ], "release_date":"2018-10-17", "publication":"\"Maintaining and breaking symmetry in homomeric coiled-coil assemblies\", Nat Commun, 9, 4132-4132", @@ -253858,10 +254460,6 @@ "sim":1.0, "partner":"7bo9" }, - { - "sim":0.9563999772, - "partner":"8b15" - }, { "sim":0.9575999975, "partner":"8a09" @@ -253882,6 +254480,10 @@ "sim":1.0, "partner":"6g6g" }, + { + "sim":0.976000011, + "partner":"7nfh" + }, { "sim":0.9879999757, "partner":"3r4h" @@ -253890,13 +254492,13 @@ "sim":1.0, "partner":"7bim" }, - { - "sim":0.976000011, - "partner":"7nfh" - }, { "sim":0.9581999779, "partner":"6yaz" + }, + { + "sim":0.9563999772, + "partner":"8b15" } ], "struct_thr_sim_natural":[ @@ -253910,7 +254512,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"7bo9" + "partner":"6g69" }, "struct_max_sim_natural":[ @@ -253975,79 +254577,79 @@ ], "subtitle":"Crystal structure of a parallel seven-helix coiled coil cc-type2-il-sg-l17e", "tags":[ - "synthetic construct", - "alpha-helical bundle", - "de novo protein", "coiled coil", - "de novo" + "de novo", + "de novo protein", + "alpha-helical bundle", + "synthetic construct" ], "keywords":[ - "maximise", - "without", - "structural", - "reported", - "chains", + "designed", + "form", + "c", + "central", + "symmetry", + "design", + "cavities", "one", - "channels", + "hydrophobic", "another", - "helices", + "water", + "structural", + "show", + "hallmark", + "classes", + "lining", + "interest", + "structures", + "lumen", + "natural", + "maintained", + "around", + "side", + "surprising", "accessible", - "placement", - "cc", - "assemblies", + "assembly", + "aliphatic", + "residues", + "otherwise", "n", - "functionalised", - "ccs", - "barrels", "extended", + "without", + "hitherto", + "placement", + "dihedral", "accessed", - "nonetheless", - "adjust", - "designed", - "unobserved", + "ccs", + "folding", + "strategic", "subset", - "interest", + "cyclic", "surfaces", - "aliphatic", - "residues", - "maintained", - "strategic", - "nature", - "leading", - "classes", - "lining", - "central", - "hallmark", - "increasingly", "drive", - "show", - "lumen", - "design", - "wrap", - "structures", + "give", "protein", + "wrap", "buried", + "nature", "given", - "hydrophobic", - "natural", - "symmetry", - "dihedral", - "c", - "cavities", - "assembly", - "water", - "give", - "form", - "hitherto", - "side", - "folding", - "around", - "otherwise", "packing", - "cyclic", - "surprising", - "five", - "collapse" + "leading", + "cc", + "adjust", + "reported", + "channels", + "increasingly", + "nonetheless", + "helices", + "functionalised", + "assemblies", + "chains", + "collapse", + "unobserved", + "maximise", + "barrels", + "five" ], "release_date":"2018-10-17", "publication":"\"Maintaining and breaking symmetry in homomeric coiled-coil assemblies\", Nat Commun, 9, 4132-4132", @@ -254120,14 +254722,14 @@ "sim":1.0, "partner":"6g66" }, - { - "sim":0.9897999763, - "partner":"6eiz" - }, { "sim":0.9986000061, "partner":"4pn9" }, + { + "sim":0.9897999763, + "partner":"6eiz" + }, { "sim":1.0, "partner":"7bo8" @@ -254136,17 +254738,13 @@ "sim":1.0, "partner":"7bo9" }, - { - "sim":0.9937999845, - "partner":"6g6a" - }, { "sim":0.9987000227, "partner":"6g65" }, { - "sim":0.9714000225, - "partner":"8b15" + "sim":0.9937999845, + "partner":"6g6a" }, { "sim":1.0, @@ -254176,6 +254774,10 @@ "sim":1.0, "partner":"7boa" }, + { + "sim":0.9714000225, + "partner":"8b15" + }, { "sim":0.9804000258, "partner":"6g6g" @@ -254297,79 +254899,79 @@ ], "subtitle":"Crystal structure of a parallel six-helix coiled coil cc-type2-ll", "tags":[ - "synthetic construct", - "alpha-helical bundle", - "de novo protein", "coiled coil", - "de novo" + "de novo", + "de novo protein", + "alpha-helical bundle", + "synthetic construct" ], "keywords":[ - "maximise", - "without", - "structural", - "reported", - "chains", + "designed", + "form", + "c", + "central", + "symmetry", + "design", + "cavities", "one", - "channels", + "hydrophobic", "another", - "helices", + "water", + "structural", + "show", + "hallmark", + "classes", + "lining", + "interest", + "structures", + "lumen", + "natural", + "maintained", + "around", + "side", + "surprising", "accessible", - "placement", - "cc", - "assemblies", + "assembly", + "aliphatic", + "residues", + "otherwise", "n", - "functionalised", - "ccs", - "barrels", "extended", + "without", + "hitherto", + "placement", + "dihedral", "accessed", - "nonetheless", - "adjust", - "designed", - "unobserved", + "ccs", + "folding", + "strategic", "subset", - "interest", + "cyclic", "surfaces", - "aliphatic", - "residues", - "maintained", - "strategic", - "nature", - "leading", - "classes", - "lining", - "central", - "hallmark", - "increasingly", "drive", - "show", - "lumen", - "design", - "wrap", - "structures", + "give", "protein", + "wrap", "buried", + "nature", "given", - "hydrophobic", - "natural", - "symmetry", - "dihedral", - "c", - "cavities", - "assembly", - "water", - "give", - "form", - "hitherto", - "side", - "folding", - "around", - "otherwise", "packing", - "cyclic", - "surprising", - "five", - "collapse" + "leading", + "cc", + "adjust", + "reported", + "channels", + "increasingly", + "nonetheless", + "helices", + "functionalised", + "assemblies", + "chains", + "collapse", + "unobserved", + "maximise", + "barrels", + "five" ], "release_date":"2018-10-17", "publication":"\"Maintaining and breaking symmetry in homomeric coiled-coil assemblies\", Nat Commun, 9, 4132-4132", @@ -254406,10 +255008,6 @@ ], "struct_thr_sim_designed":[ - { - "sim":0.996900022, - "partner":"8b16" - }, { "sim":0.9961000085, "partner":"4pn9" @@ -254418,177 +255016,185 @@ "sim":0.9940000176, "partner":"6eiz" }, + { + "sim":0.9929999709, + "partner":"6g68" + }, + { + "sim":0.993900001, + "partner":"6g69" + }, { "sim":0.9918000102, "partner":"6g6b" }, { - "sim":0.996999979, - "partner":"6g6f" + "sim":0.992200017, + "partner":"6g6c" }, { - "sim":0.9898999929, - "partner":"7bat" + "sim":0.9983999729, + "partner":"6g6d" }, { - "sim":0.9983999729, - "partner":"7baw" + "sim":0.996999979, + "partner":"6g6f" }, { - "sim":0.9854999781, - "partner":"8a09" + "sim":0.996900022, + "partner":"6g6g" }, { - "sim":0.9797000289, - "partner":"8b15" + "sim":0.9955000281, + "partner":"6xy1" }, { - "sim":0.9990000129, - "partner":"4pna" + "sim":0.9983999729, + "partner":"6yb2" }, { - "sim":0.9975000024, - "partner":"5ez8" + "sim":0.9983999729, + "partner":"7baw" }, { "sim":0.9951999784, - "partner":"7bim" + "partner":"7nfg" }, { - "sim":0.9947999716, - "partner":"7nfj" + "sim":0.996900022, + "partner":"8b16" }, { - "sim":0.9912999868, - "partner":"7nfk" + "sim":0.9990000129, + "partner":"4pna" }, { - "sim":0.9970999956, - "partner":"5ezc" + "sim":0.9898999929, + "partner":"7bat" }, { - "sim":0.9955000281, - "partner":"6xy1" + "sim":0.9951000214, + "partner":"7nff" }, { "sim":0.9911999702, "partner":"7nfh" }, { - "sim":0.992299974, - "partner":"5ez9" - }, - { - "sim":0.9937999845, - "partner":"6eik" + "sim":0.9947999716, + "partner":"7nfj" }, { - "sim":0.9925000072, - "partner":"6zt1" + "sim":0.9854999781, + "partner":"8a09" }, { - "sim":0.993900001, - "partner":"7bas" + "sim":0.9975000024, + "partner":"5ez8" }, { - "sim":0.9822999835, - "partner":"7bau" + "sim":0.9889000058, + "partner":"6g65" }, { - "sim":0.991599977, - "partner":"7nfn" + "sim":0.992200017, + "partner":"6g66" }, { - "sim":0.9848999977, - "partner":"7nfo" + "sim":0.9876000285, + "partner":"6g67" }, { - "sim":0.996900022, - "partner":"7a1t" + "sim":0.9951999784, + "partner":"7bim" }, { - "sim":0.9929000139, - "partner":"7bo9" + "sim":0.9951999784, + "partner":"7nfi" }, { "sim":0.9941999912, "partner":"7nfl" }, { - "sim":0.9983999729, - "partner":"6g6d" + "sim":0.9908000231, + "partner":"7nfm" }, { - "sim":0.993900001, - "partner":"6g69" + "sim":0.9848999977, + "partner":"7nfo" }, { - "sim":0.996900022, - "partner":"6g6g" + "sim":0.9711999893, + "partner":"6yaz" }, { - "sim":0.9951999784, - "partner":"7bav" + "sim":0.992299974, + "partner":"5ez9" }, { - "sim":0.9711999893, - "partner":"6yaz" + "sim":0.9962999821, + "partner":"5eza" }, { - "sim":0.9749000072, - "partner":"6yb0" + "sim":0.9970999956, + "partner":"5ezc" }, { - "sim":0.9987999797, - "partner":"7bo8" + "sim":0.991599977, + "partner":"7nfn" }, { - "sim":0.9929999709, - "partner":"6g68" + "sim":0.9925000072, + "partner":"6zt1" }, { - "sim":0.992200017, - "partner":"6g6c" + "sim":0.996900022, + "partner":"7a1t" }, { - "sim":0.9983999729, - "partner":"6yb2" + "sim":0.993900001, + "partner":"7bas" }, { "sim":0.9951999784, - "partner":"7nfg" + "partner":"7bav" }, { - "sim":0.9889000058, - "partner":"6g65" + "sim":0.9987999797, + "partner":"7bo8" }, { - "sim":0.992200017, - "partner":"6g66" + "sim":0.9929000139, + "partner":"7bo9" }, { - "sim":0.9876000285, - "partner":"6g67" + "sim":0.996999979, + "partner":"7boa" }, { - "sim":0.9951000214, - "partner":"7nff" + "sim":0.9749000072, + "partner":"6yb0" }, { - "sim":0.9951999784, - "partner":"7nfi" + "sim":0.9937999845, + "partner":"6eik" }, { - "sim":0.9908000231, - "partner":"7nfm" + "sim":0.9822999835, + "partner":"7bau" }, { - "sim":0.9962999821, - "partner":"5eza" + "sim":0.959100008, + "partner":"9gf2" }, { - "sim":0.996999979, - "partner":"7boa" + "sim":0.9797000289, + "partner":"8b15" + }, + { + "sim":0.9912999868, + "partner":"7nfk" }, { "sim":0.9624999762, @@ -254683,79 +255289,79 @@ ], "subtitle":"Crystal structure of a parallel six-helix coiled coil cc-type2-ll-l17q", "tags":[ - "synthetic construct", - "alpha-helical bundle", - "de novo protein", "coiled coil", - "de novo" + "de novo", + "de novo protein", + "alpha-helical bundle", + "synthetic construct" ], "keywords":[ - "maximise", - "without", - "structural", - "reported", - "chains", + "designed", + "form", + "c", + "central", + "symmetry", + "design", + "cavities", "one", - "channels", + "hydrophobic", "another", - "helices", + "water", + "structural", + "show", + "hallmark", + "classes", + "lining", + "interest", + "structures", + "lumen", + "natural", + "maintained", + "around", + "side", + "surprising", "accessible", - "placement", - "cc", - "assemblies", + "assembly", + "aliphatic", + "residues", + "otherwise", "n", - "functionalised", - "ccs", - "barrels", "extended", + "without", + "hitherto", + "placement", + "dihedral", "accessed", - "nonetheless", - "adjust", - "designed", - "unobserved", + "ccs", + "folding", + "strategic", "subset", - "interest", + "cyclic", "surfaces", - "aliphatic", - "residues", - "maintained", - "strategic", - "nature", - "leading", - "classes", - "lining", - "central", - "hallmark", - "increasingly", "drive", - "show", - "lumen", - "design", - "wrap", - "structures", + "give", "protein", + "wrap", "buried", + "nature", "given", - "hydrophobic", - "natural", - "symmetry", - "dihedral", - "c", - "cavities", - "assembly", - "water", - "give", - "form", - "hitherto", - "side", - "folding", - "around", - "otherwise", "packing", - "cyclic", - "surprising", - "five", - "collapse" + "leading", + "cc", + "adjust", + "reported", + "channels", + "increasingly", + "nonetheless", + "helices", + "functionalised", + "assemblies", + "chains", + "collapse", + "unobserved", + "maximise", + "barrels", + "five" ], "release_date":"2018-10-17", "publication":"\"Maintaining and breaking symmetry in homomeric coiled-coil assemblies\", Nat Commun, 9, 4132-4132", @@ -254797,36 +255403,48 @@ "partner":"8b16" }, { - "sim":0.996999979, - "partner":"6g6f" + "sim":0.9957000017, + "partner":"6g6c" + }, + { + "sim":0.9986000061, + "partner":"6g69" }, { "sim":0.996999979, - "partner":"4pn9" + "partner":"6g6f" }, { "sim":0.9984999895, "partner":"6eiz" }, + { + "sim":0.9900000095, + "partner":"7nfo" + }, + { + "sim":0.996999979, + "partner":"4pn9" + }, { "sim":0.9940000176, "partner":"6g6a" }, { - "sim":0.9923999906, - "partner":"8a09" + "sim":0.9941999912, + "partner":"6g6d" }, { - "sim":0.9933000207, - "partner":"7bat" + "sim":0.9966999888, + "partner":"6xy1" }, { "sim":0.9941999912, "partner":"7baw" }, { - "sim":0.9882000089, - "partner":"8b15" + "sim":0.9957000017, + "partner":"7nfj" }, { "sim":0.9973000288, @@ -254836,69 +255454,81 @@ "sim":0.9962000251, "partner":"5ez8" }, + { + "sim":1.0, + "partner":"6g68" + }, + { + "sim":1.0, + "partner":"6g6g" + }, + { + "sim":0.9933000207, + "partner":"7bat" + }, { "sim":0.9930999875, "partner":"7bim" }, { - "sim":0.9936000109, - "partner":"7nfk" + "sim":0.9940999746, + "partner":"7nff" }, { - "sim":0.9957000017, - "partner":"7nfj" + "sim":0.9933000207, + "partner":"7nfi" }, { - "sim":0.9986000061, - "partner":"7bo9" + "sim":0.9933000207, + "partner":"7nfl" }, { - "sim":0.9900000095, - "partner":"7nfo" + "sim":0.9927999973, + "partner":"7nfm" }, { - "sim":0.9972000122, - "partner":"5ezc" + "sim":0.9769999981, + "partner":"6yb0" }, { - "sim":0.9966999888, - "partner":"6xy1" + "sim":0.9923999906, + "partner":"8a09" }, { - "sim":0.9984999895, - "partner":"6eik" + "sim":0.9933000207, + "partner":"5eza" }, { - "sim":0.9944000244, - "partner":"6zt1" + "sim":0.9972000122, + "partner":"5ezc" }, { - "sim":1.0, - "partner":"7bas" + "sim":0.9958000183, + "partner":"6g65" }, { - "sim":0.9986000061, - "partner":"6g69" + "sim":0.994599998, + "partner":"6g66" }, { - "sim":0.9984999895, - "partner":"7a1t" + "sim":0.9934999943, + "partner":"6g67" }, { - "sim":0.9890999794, - "partner":"7bau" + "sim":0.9936000109, + "partner":"7nfk" }, { - "sim":0.9951999784, - "partner":"7nfn" + "sim":0.9986000061, + "partner":"7bo8" }, { - "sim":0.9933000207, - "partner":"7nfl" + "sim":0.9986000061, + "partner":"7bo9" }, { - "sim":0.9957000017, - "partner":"5ez9" + "sim":1.0, + "partner":"7nfg" }, { "sim":0.992200017, @@ -254906,63 +255536,63 @@ }, { "sim":0.9957000017, - "partner":"6g6c" + "partner":"5ez9" }, { - "sim":0.9941999912, - "partner":"6g6d" + "sim":0.9962000251, + "partner":"6yb2" }, { - "sim":1.0, - "partner":"7bav" + "sim":0.9951999784, + "partner":"7nfn" }, { - "sim":1.0, - "partner":"6g6g" + "sim":0.9919000268, + "partner":"7nfp" }, { - "sim":0.9986000061, - "partner":"7bo8" + "sim":0.9984999895, + "partner":"7a1t" }, { - "sim":0.9718999863, - "partner":"6yaz" + "sim":1.0, + "partner":"7bas" }, { - "sim":0.9940999746, - "partner":"7nff" + "sim":1.0, + "partner":"7bav" }, { - "sim":0.9958000183, - "partner":"6g65" + "sim":0.9984999895, + "partner":"6eik" }, { - "sim":0.994599998, - "partner":"6g66" + "sim":0.9944000244, + "partner":"6zt1" }, { - "sim":1.0, - "partner":"6g68" + "sim":0.9718999863, + "partner":"6yaz" }, { - "sim":0.9933000207, - "partner":"7nfi" + "sim":0.9890999794, + "partner":"7bau" }, { - "sim":0.9927999973, - "partner":"7nfm" + "sim":0.9943000078, + "partner":"7boa" }, { - "sim":0.9934999943, - "partner":"6g67" + "sim":0.9542999864, + "partner":"9gf2" }, { - "sim":1.0, - "partner":"7nfg" + "sim":0.9882000089, + "partner":"8b15" }, { - "sim":0.9962000251, - "partner":"6yb2" + "sim":0.9514999986, + "partner":"5eze" }, { "sim":0.9746000171, @@ -254971,26 +255601,6 @@ { "sim":0.9728999734, "partner":"6xy0" - }, - { - "sim":0.9943000078, - "partner":"7boa" - }, - { - "sim":0.9769999981, - "partner":"6yb0" - }, - { - "sim":0.9933000207, - "partner":"5eza" - }, - { - "sim":0.9919000268, - "partner":"7nfp" - }, - { - "sim":0.9514999986, - "partner":"5eze" } ], "struct_thr_sim_natural":[ @@ -255069,79 +255679,79 @@ ], "subtitle":"Crystal structure of a parallel six-helix coiled coil cc-type2-ll-l17e", "tags":[ - "synthetic construct", - "alpha-helical bundle", - "de novo protein", "coiled coil", - "de novo" + "de novo", + "de novo protein", + "alpha-helical bundle", + "synthetic construct" ], "keywords":[ - "maximise", - "without", - "structural", - "reported", - "chains", + "designed", + "form", + "c", + "central", + "symmetry", + "design", + "cavities", "one", - "channels", + "hydrophobic", "another", - "helices", + "water", + "structural", + "show", + "hallmark", + "classes", + "lining", + "interest", + "structures", + "lumen", + "natural", + "maintained", + "around", + "side", + "surprising", "accessible", - "placement", - "cc", - "assemblies", + "assembly", + "aliphatic", + "residues", + "otherwise", "n", - "functionalised", - "ccs", - "barrels", "extended", + "without", + "hitherto", + "placement", + "dihedral", "accessed", - "nonetheless", - "adjust", - "designed", - "unobserved", + "ccs", + "folding", + "strategic", "subset", - "interest", + "cyclic", "surfaces", - "aliphatic", - "residues", - "maintained", - "strategic", - "nature", - "leading", - "classes", - "lining", - "central", - "hallmark", - "increasingly", "drive", - "show", - "lumen", - "design", - "wrap", - "structures", + "give", "protein", + "wrap", "buried", + "nature", "given", - "hydrophobic", - "natural", - "symmetry", - "dihedral", - "c", - "cavities", - "assembly", - "water", - "give", - "form", - "hitherto", - "side", - "folding", - "around", - "otherwise", "packing", - "cyclic", - "surprising", - "five", - "collapse" + "leading", + "cc", + "adjust", + "reported", + "channels", + "increasingly", + "nonetheless", + "helices", + "functionalised", + "assemblies", + "chains", + "collapse", + "unobserved", + "maximise", + "barrels", + "five" ], "release_date":"2018-10-17", "publication":"\"Maintaining and breaking symmetry in homomeric coiled-coil assemblies\", Nat Commun, 9, 4132-4132", @@ -255178,17 +255788,25 @@ ], "struct_thr_sim_designed":[ + { + "sim":1.0, + "partner":"6xy1" + }, { "sim":1.0, "partner":"6g69" }, + { + "sim":1.0, + "partner":"8b16" + }, { "sim":0.994599998, "partner":"6g6b" }, { - "sim":1.0, - "partner":"8b16" + "sim":0.9983999729, + "partner":"6g6d" }, { "sim":1.0, @@ -255199,24 +255817,24 @@ "partner":"4pn9" }, { - "sim":0.9955000281, - "partner":"6eiz" + "sim":1.0, + "partner":"7nfj" }, { "sim":1.0, - "partner":"6xy1" + "partner":"4pna" }, { - "sim":0.9811999798, - "partner":"7nfo" + "sim":1.0, + "partner":"5ez8" }, { - "sim":1.0, - "partner":"4pna" + "sim":0.9955000281, + "partner":"6eiz" }, { "sim":1.0, - "partner":"5ez8" + "partner":"7bim" }, { "sim":0.9986000061, @@ -255226,10 +255844,6 @@ "sim":1.0, "partner":"7nfi" }, - { - "sim":1.0, - "partner":"7nfj" - }, { "sim":1.0, "partner":"7nfl" @@ -255239,8 +255853,8 @@ "partner":"7nfm" }, { - "sim":0.9593999982, - "partner":"8a09" + "sim":0.9769999981, + "partner":"6yb0" }, { "sim":0.9921000004, @@ -255248,28 +255862,12 @@ }, { "sim":0.9983999729, - "partner":"6g6d" + "partner":"7bat" }, { "sim":1.0, "partner":"7baw" }, - { - "sim":1.0, - "partner":"7bim" - }, - { - "sim":0.9769999981, - "partner":"6yb0" - }, - { - "sim":0.9593999982, - "partner":"7nfk" - }, - { - "sim":0.9541000128, - "partner":"8b15" - }, { "sim":1.0, "partner":"5eza" @@ -255288,23 +255886,23 @@ }, { "sim":1.0, - "partner":"6g6g" + "partner":"6g67" }, { - "sim":0.9983999729, - "partner":"7bat" + "sim":1.0, + "partner":"6g6g" }, { "sim":1.0, - "partner":"6g67" + "partner":"7bo9" }, { "sim":1.0, "partner":"6g68" }, { - "sim":0.9829999804, - "partner":"7nfh" + "sim":1.0, + "partner":"7nfn" }, { "sim":1.0, @@ -255320,23 +255918,19 @@ }, { "sim":1.0, - "partner":"7bo8" + "partner":"7bas" }, { "sim":1.0, - "partner":"7bo9" + "partner":"7bo8" }, { "sim":1.0, "partner":"7nfg" }, { - "sim":1.0, - "partner":"7nfn" - }, - { - "sim":0.956799984, - "partner":"6eik" + "sim":0.9646999836, + "partner":"9gf2" }, { "sim":1.0, @@ -255348,11 +255942,11 @@ }, { "sim":1.0, - "partner":"7bas" + "partner":"7bav" }, { "sim":1.0, - "partner":"7bav" + "partner":"6xy0" }, { "sim":0.9574999809, @@ -255364,15 +255958,35 @@ }, { "sim":1.0, - "partner":"7boa" + "partner":"6xxz" }, { "sim":1.0, - "partner":"6xxz" + "partner":"7boa" }, { - "sim":1.0, - "partner":"6xy0" + "sim":0.9811999798, + "partner":"7nfo" + }, + { + "sim":0.9593999982, + "partner":"8a09" + }, + { + "sim":0.9593999982, + "partner":"7nfk" + }, + { + "sim":0.9541000128, + "partner":"8b15" + }, + { + "sim":0.9829999804, + "partner":"7nfh" + }, + { + "sim":0.956799984, + "partner":"6eik" } ], "struct_thr_sim_natural":[ @@ -255451,79 +256065,79 @@ ], "subtitle":"Crystal structure of a parallel six-helix coiled coil cc-type2-ll-sg", "tags":[ - "synthetic construct", - "alpha-helical bundle", - "de novo protein", "coiled coil", - "de novo" + "de novo", + "de novo protein", + "alpha-helical bundle", + "synthetic construct" ], "keywords":[ - "maximise", - "without", - "structural", - "reported", - "chains", + "designed", + "form", + "c", + "central", + "symmetry", + "design", + "cavities", "one", - "channels", + "hydrophobic", "another", - "helices", + "water", + "structural", + "show", + "hallmark", + "classes", + "lining", + "interest", + "structures", + "lumen", + "natural", + "maintained", + "around", + "side", + "surprising", "accessible", - "placement", - "cc", - "assemblies", + "assembly", + "aliphatic", + "residues", + "otherwise", "n", - "functionalised", - "ccs", - "barrels", "extended", + "without", + "hitherto", + "placement", + "dihedral", "accessed", - "nonetheless", - "adjust", - "designed", - "unobserved", + "ccs", + "folding", + "strategic", "subset", - "interest", + "cyclic", "surfaces", - "aliphatic", - "residues", - "maintained", - "strategic", - "nature", - "leading", - "classes", - "lining", - "central", - "hallmark", - "increasingly", "drive", - "show", - "lumen", - "design", - "wrap", - "structures", + "give", "protein", + "wrap", "buried", + "nature", "given", - "hydrophobic", - "natural", - "symmetry", - "dihedral", - "c", - "cavities", - "assembly", - "water", - "give", - "form", - "hitherto", - "side", - "folding", - "around", - "otherwise", "packing", - "cyclic", - "surprising", - "five", - "collapse" + "leading", + "cc", + "adjust", + "reported", + "channels", + "increasingly", + "nonetheless", + "helices", + "functionalised", + "assemblies", + "chains", + "collapse", + "unobserved", + "maximise", + "barrels", + "five" ], "release_date":"2018-10-17", "publication":"\"Maintaining and breaking symmetry in homomeric coiled-coil assemblies\", Nat Commun, 9, 4132-4132", @@ -255560,21 +256174,21 @@ ], "struct_thr_sim_designed":[ - { - "sim":0.9966999888, - "partner":"4pn9" - }, { "sim":0.9907000065, "partner":"6eiz" }, { "sim":0.9987000227, - "partner":"6g68" + "partner":"6g69" + }, + { + "sim":0.9966999888, + "partner":"4pn9" }, { "sim":0.9987000227, - "partner":"6g69" + "partner":"6g68" }, { "sim":0.9951999784, @@ -255584,6 +256198,18 @@ "sim":0.9728000164, "partner":"8a09" }, + { + "sim":0.9682000279, + "partner":"8b15" + }, + { + "sim":0.9955000281, + "partner":"7bav" + }, + { + "sim":0.9851999879, + "partner":"7bau" + }, { "sim":0.992200017, "partner":"7bat" @@ -255596,57 +256222,49 @@ "sim":0.9937999845, "partner":"7bas" }, - { - "sim":0.9955000281, - "partner":"7bav" - }, - { - "sim":0.9851999879, - "partner":"7bau" - }, { "sim":0.9936000109, "partner":"7bim" }, { - "sim":0.9983000159, - "partner":"7a1t" + "sim":0.9984999895, + "partner":"6g6f" }, { - "sim":0.9983999729, - "partner":"6g6a" + "sim":0.9933000207, + "partner":"7nfh" }, { - "sim":0.9879000187, - "partner":"6g6b" + "sim":0.9944999814, + "partner":"6g6g" }, { - "sim":0.9983999729, - "partner":"6g6c" + "sim":0.9869999886, + "partner":"7nfo" }, { - "sim":0.9984999895, - "partner":"6g6f" + "sim":0.9983999729, + "partner":"6g6c" }, { - "sim":0.9944999814, - "partner":"6g6g" + "sim":0.9957000017, + "partner":"7nfj" }, { - "sim":0.9966999888, - "partner":"6xy1" + "sim":0.9937999845, + "partner":"7nfl" }, { - "sim":1.0, - "partner":"6yb2" + "sim":0.9983999729, + "partner":"6g6a" }, { - "sim":0.996900022, - "partner":"7nfg" + "sim":0.9879000187, + "partner":"6g6b" }, { - "sim":0.9933000207, - "partner":"7nfh" + "sim":0.9983000159, + "partner":"7a1t" }, { "sim":0.9966999888, @@ -255657,88 +256275,84 @@ "partner":"5ez8" }, { - "sim":0.9848999977, - "partner":"6g65" + "sim":0.9732000232, + "partner":"7nfk" }, { - "sim":0.9990000129, - "partner":"6g66" + "sim":1.0, + "partner":"7bo8" }, { "sim":0.996900022, - "partner":"7nff" + "partner":"7nfg" }, { "sim":0.9966999888, - "partner":"7nfi" + "partner":"6xy1" }, { - "sim":0.9957000017, - "partner":"7nfj" + "sim":1.0, + "partner":"6yb2" }, { - "sim":0.9937999845, - "partner":"7nfl" + "sim":0.9667999744, + "partner":"6yaz" }, { - "sim":0.9952999949, - "partner":"7nfm" + "sim":0.9848999977, + "partner":"6g65" }, { - "sim":0.9869999886, - "partner":"7nfo" + "sim":0.9990000129, + "partner":"6g66" }, { "sim":0.9890000224, "partner":"6g67" }, { - "sim":0.9732000232, - "partner":"7nfk" + "sim":0.996900022, + "partner":"7nff" }, { - "sim":0.9983999729, - "partner":"5ez9" + "sim":0.9966999888, + "partner":"7nfi" }, { - "sim":0.9973999858, - "partner":"5eza" + "sim":0.9952999949, + "partner":"7nfm" }, { "sim":0.9983999729, - "partner":"5ezc" + "partner":"5ez9" }, { - "sim":0.9952999949, - "partner":"7nfn" + "sim":0.9983999729, + "partner":"5ezc" }, { - "sim":1.0, - "partner":"7bo8" + "sim":0.9731000066, + "partner":"6eik" }, { "sim":0.9983999729, "partner":"7bo9" }, { - "sim":1.0, - "partner":"7boa" - }, - { - "sim":0.9771999717, - "partner":"6yb0" + "sim":0.9952999949, + "partner":"7nfn" }, { - "sim":0.9731000066, - "partner":"6eik" + "sim":0.9973999858, + "partner":"5eza" }, { - "sim":0.9682000279, - "partner":"8b15" + "sim":0.9771999717, + "partner":"6yb0" }, { - "sim":0.9667999744, - "partner":"6yaz" + "sim":1.0, + "partner":"7boa" }, { "sim":0.9740999937, @@ -255776,7 +256390,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"6yb2" + "partner":"7baw" }, "struct_max_sim_natural":[ @@ -255841,79 +256455,79 @@ ], "subtitle":"Crystal structure of a parallel seven-helix coiled coil cc-type2-deli", "tags":[ - "synthetic construct", - "alpha-helical bundle", - "de novo protein", "coiled coil", - "de novo" + "de novo", + "de novo protein", + "alpha-helical bundle", + "synthetic construct" ], "keywords":[ - "maximise", - "without", - "structural", - "reported", - "chains", + "designed", + "form", + "c", + "central", + "symmetry", + "design", + "cavities", "one", - "channels", + "hydrophobic", "another", - "helices", + "water", + "structural", + "show", + "hallmark", + "classes", + "lining", + "interest", + "structures", + "lumen", + "natural", + "maintained", + "around", + "side", + "surprising", "accessible", - "placement", - "cc", - "assemblies", + "assembly", + "aliphatic", + "residues", + "otherwise", "n", - "functionalised", - "ccs", - "barrels", "extended", + "without", + "hitherto", + "placement", + "dihedral", "accessed", - "nonetheless", - "adjust", - "designed", - "unobserved", + "ccs", + "folding", + "strategic", "subset", - "interest", + "cyclic", "surfaces", - "aliphatic", - "residues", - "maintained", - "strategic", - "nature", - "leading", - "classes", - "lining", - "central", - "hallmark", - "increasingly", "drive", - "show", - "lumen", - "design", - "wrap", - "structures", + "give", "protein", + "wrap", "buried", + "nature", "given", - "hydrophobic", - "natural", - "symmetry", - "dihedral", - "c", - "cavities", - "assembly", - "water", - "give", - "form", - "hitherto", - "side", - "folding", - "around", - "otherwise", "packing", - "cyclic", - "surprising", - "five", - "collapse" + "leading", + "cc", + "adjust", + "reported", + "channels", + "increasingly", + "nonetheless", + "helices", + "functionalised", + "assemblies", + "chains", + "collapse", + "unobserved", + "maximise", + "barrels", + "five" ], "release_date":"2018-10-17", "publication":"\"Maintaining and breaking symmetry in homomeric coiled-coil assemblies\", Nat Commun, 9, 4132-4132", @@ -255982,38 +256596,34 @@ "sim":0.9747999907, "partner":"7nfo" }, - { - "sim":0.9957000017, - "partner":"5ez9" - }, { "sim":0.9944000244, "partner":"6g6a" }, - { - "sim":1.0, - "partner":"7nfm" - }, { "sim":1.0, "partner":"6g6g" }, { "sim":1.0, - "partner":"7nfl" + "partner":"7nfm" }, { - "sim":0.996999979, - "partner":"4pn9" + "sim":0.9957000017, + "partner":"5ez9" }, { - "sim":0.9947000146, - "partner":"7bat" + "sim":1.0, + "partner":"7nfl" }, { "sim":0.9613000154, "partner":"8b15" }, + { + "sim":0.996999979, + "partner":"4pn9" + }, { "sim":0.9829999804, "partner":"6eiz" @@ -256022,6 +256632,10 @@ "sim":1.0, "partner":"7a1t" }, + { + "sim":0.9947000146, + "partner":"7bat" + }, { "sim":1.0, "partner":"6yb2" @@ -256046,10 +256660,6 @@ "sim":1.0, "partner":"7baw" }, - { - "sim":1.0, - "partner":"7nfn" - }, { "sim":1.0, "partner":"7nff" @@ -256062,6 +256672,10 @@ "sim":0.9718999863, "partner":"7bau" }, + { + "sim":1.0, + "partner":"7nfn" + }, { "sim":1.0, "partner":"8b16" @@ -256090,29 +256704,29 @@ "sim":1.0, "partner":"6g66" }, - { - "sim":1.0, - "partner":"5eza" - }, { "sim":0.9979000092, "partner":"6g6d" }, { "sim":1.0, - "partner":"6g6c" + "partner":"5eza" }, { "sim":1.0, - "partner":"7boa" + "partner":"6g6c" }, { "sim":1.0, - "partner":"6g68" + "partner":"7boa" }, { "sim":0.9546999931, "partner":"7bo9" + }, + { + "sim":1.0, + "partner":"6g68" } ], "struct_thr_sim_natural":[ @@ -256191,79 +256805,79 @@ ], "subtitle":"Crystal structure of a parallel eight-helix coiled coil cc-type2-lf", "tags":[ - "synthetic construct", - "alpha-helical bundle", - "de novo protein", "coiled coil", - "de novo" + "de novo", + "de novo protein", + "alpha-helical bundle", + "synthetic construct" ], "keywords":[ - "maximise", - "without", - "structural", - "reported", - "chains", + "designed", + "form", + "c", + "central", + "symmetry", + "design", + "cavities", "one", - "channels", + "hydrophobic", "another", - "helices", + "water", + "structural", + "show", + "hallmark", + "classes", + "lining", + "interest", + "structures", + "lumen", + "natural", + "maintained", + "around", + "side", + "surprising", "accessible", - "placement", - "cc", - "assemblies", + "assembly", + "aliphatic", + "residues", + "otherwise", "n", - "functionalised", - "ccs", - "barrels", "extended", + "without", + "hitherto", + "placement", + "dihedral", "accessed", - "nonetheless", - "adjust", - "designed", - "unobserved", + "ccs", + "folding", + "strategic", "subset", - "interest", + "cyclic", "surfaces", - "aliphatic", - "residues", - "maintained", - "strategic", - "nature", - "leading", - "classes", - "lining", - "central", - "hallmark", - "increasingly", "drive", - "show", - "lumen", - "design", - "wrap", - "structures", + "give", "protein", + "wrap", "buried", + "nature", "given", - "hydrophobic", - "natural", - "symmetry", - "dihedral", - "c", - "cavities", - "assembly", - "water", - "give", - "form", - "hitherto", - "side", - "folding", - "around", - "otherwise", "packing", - "cyclic", - "surprising", - "five", - "collapse" + "leading", + "cc", + "adjust", + "reported", + "channels", + "increasingly", + "nonetheless", + "helices", + "functionalised", + "assemblies", + "chains", + "collapse", + "unobserved", + "maximise", + "barrels", + "five" ], "release_date":"2018-10-17", "publication":"\"Maintaining and breaking symmetry in homomeric coiled-coil assemblies\", Nat Commun, 9, 4132-4132", @@ -256300,10 +256914,6 @@ ], "struct_thr_sim_designed":[ - { - "sim":1.0, - "partner":"7bo8" - }, { "sim":1.0, "partner":"7bo9" @@ -256316,97 +256926,113 @@ "sim":1.0, "partner":"6eiz" }, + { + "sim":0.9983999729, + "partner":"8a09" + }, { "sim":1.0, "partner":"8b16" }, { - "sim":1.0, - "partner":"6xy1" + "sim":0.9951000214, + "partner":"8b15" }, { "sim":1.0, "partner":"4pna" }, + { + "sim":0.9990000129, + "partner":"7nfk" + }, { "sim":1.0, - "partner":"7nff" + "partner":"7bo8" }, { "sim":1.0, - "partner":"7nfg" + "partner":"7bim" }, { "sim":1.0, - "partner":"7nfl" + "partner":"5ez8" + }, + { + "sim":0.996999979, + "partner":"6g6b" + }, + { + "sim":1.0, + "partner":"7bas" }, { "sim":0.9957000017, "partner":"7nfo" }, { - "sim":0.9983999729, - "partner":"8a09" + "sim":0.9990000129, + "partner":"6eik" }, { - "sim":0.9951000214, - "partner":"8b15" + "sim":0.996900022, + "partner":"6g6a" }, { "sim":1.0, - "partner":"7bim" + "partner":"6zt1" }, { - "sim":0.9990000129, - "partner":"7nfk" + "sim":1.0, + "partner":"7bat" }, { "sim":1.0, - "partner":"5ez8" + "partner":"6xy1" }, { "sim":1.0, - "partner":"6g6c" + "partner":"7nfl" }, { "sim":1.0, - "partner":"7nfm" + "partner":"7a1t" }, { - "sim":0.996999979, - "partner":"6g6b" + "sim":1.0, + "partner":"7baw" }, { "sim":1.0, - "partner":"6yb2" + "partner":"5ezc" }, { "sim":1.0, - "partner":"7a1t" + "partner":"7nfj" }, { "sim":1.0, - "partner":"7bas" + "partner":"7nfn" }, { "sim":1.0, "partner":"7bav" }, { - "sim":0.9990000129, - "partner":"6eik" + "sim":0.9983999729, + "partner":"5ez9" }, { - "sim":1.0, - "partner":"6zt1" + "sim":0.9965999722, + "partner":"7nfh" }, { - "sim":1.0, - "partner":"5ezc" + "sim":0.9951999784, + "partner":"7bau" }, { - "sim":0.996900022, - "partner":"6g6a" + "sim":0.9769999981, + "partner":"6yb0" }, { "sim":1.0, @@ -256414,79 +257040,71 @@ }, { "sim":1.0, - "partner":"7bat" + "partner":"7nfg" }, { "sim":1.0, - "partner":"7baw" + "partner":"7nff" }, { "sim":1.0, - "partner":"7nfi" + "partner":"6g6c" }, { "sim":1.0, - "partner":"7nfj" + "partner":"6yb2" }, { "sim":1.0, - "partner":"7nfn" - }, - { - "sim":0.9769999981, - "partner":"6yb0" + "partner":"7nfm" }, { "sim":1.0, - "partner":"5eza" - }, - { - "sim":0.9965999722, - "partner":"7nfh" + "partner":"6g69" }, { - "sim":0.9983999729, - "partner":"5ez9" + "sim":0.9761999846, + "partner":"6yaz" }, { "sim":1.0, - "partner":"6g65" + "partner":"5eza" }, { - "sim":0.9983999729, - "partner":"7boa" + "sim":1.0, + "partner":"7nfi" }, { "sim":1.0, "partner":"7nfp" }, { - "sim":0.9973999858, - "partner":"6g67" + "sim":0.9697999954, + "partner":"9gf2" }, { "sim":1.0, - "partner":"6xy0" + "partner":"6g65" }, { "sim":1.0, - "partner":"6xxz" + "partner":"6xy0" }, { - "sim":1.0, - "partner":"6g69" + "sim":0.9983999729, + "partner":"7boa" }, { - "sim":1.0, - "partner":"6g66" + "sim":0.9973999858, + "partner":"6g67" }, { - "sim":0.9761999846, - "partner":"6yaz" + "sim":1.0, + "partner":"6xxz" }, { - "sim":0.9951999784, - "partner":"7bau" + "sim":1.0, + "partner":"6g66" }, { "sim":1.0, @@ -256577,79 +257195,79 @@ ], "subtitle":"Crystal structure of a parallel six-helix coiled coil cc-type2-fi", "tags":[ - "synthetic construct", - "alpha-helical bundle", - "de novo protein", "coiled coil", - "de novo" + "de novo", + "de novo protein", + "alpha-helical bundle", + "synthetic construct" ], "keywords":[ - "maximise", - "without", - "structural", - "reported", - "chains", + "designed", + "form", + "c", + "central", + "symmetry", + "design", + "cavities", "one", - "channels", + "hydrophobic", "another", - "helices", + "water", + "structural", + "show", + "hallmark", + "classes", + "lining", + "interest", + "structures", + "lumen", + "natural", + "maintained", + "around", + "side", + "surprising", "accessible", - "placement", - "cc", - "assemblies", + "assembly", + "aliphatic", + "residues", + "otherwise", "n", - "functionalised", - "ccs", - "barrels", "extended", + "without", + "hitherto", + "placement", + "dihedral", "accessed", - "nonetheless", - "adjust", - "designed", - "unobserved", + "ccs", + "folding", + "strategic", "subset", - "interest", + "cyclic", "surfaces", - "aliphatic", - "residues", - "maintained", - "strategic", - "nature", - "leading", - "classes", - "lining", - "central", - "hallmark", - "increasingly", "drive", - "show", - "lumen", - "design", - "wrap", - "structures", + "give", "protein", + "wrap", "buried", + "nature", "given", - "hydrophobic", - "natural", - "symmetry", - "dihedral", - "c", - "cavities", - "assembly", - "water", - "give", - "form", - "hitherto", - "side", - "folding", - "around", - "otherwise", "packing", - "cyclic", - "surprising", - "five", - "collapse" + "leading", + "cc", + "adjust", + "reported", + "channels", + "increasingly", + "nonetheless", + "helices", + "functionalised", + "assemblies", + "chains", + "collapse", + "unobserved", + "maximise", + "barrels", + "five" ], "release_date":"2018-10-17", "publication":"\"Maintaining and breaking symmetry in homomeric coiled-coil assemblies\", Nat Commun, 9, 4132-4132", @@ -256686,14 +257304,34 @@ ], "struct_thr_sim_designed":[ + { + "sim":0.9611999989, + "partner":"6yaz" + }, { "sim":1.0, - "partner":"6eiz" + "partner":"6yb2" }, { "sim":1.0, "partner":"7nfj" }, + { + "sim":1.0, + "partner":"4pn9" + }, + { + "sim":1.0, + "partner":"6eiz" + }, + { + "sim":1.0, + "partner":"7nfg" + }, + { + "sim":1.0, + "partner":"7nfi" + }, { "sim":1.0, "partner":"6xy1" @@ -256704,35 +257342,39 @@ }, { "sim":1.0, - "partner":"4pn9" + "partner":"4pna" + }, + { + "sim":1.0, + "partner":"7nfm" }, { "sim":0.9714000225, "partner":"8a09" }, { - "sim":0.9792000055, - "partner":"7nfo" + "sim":1.0, + "partner":"5ez8" }, { "sim":1.0, - "partner":"6yb2" + "partner":"7bim" }, { - "sim":0.9611999989, - "partner":"6yaz" + "sim":0.9792000055, + "partner":"7nfo" }, { "sim":1.0, - "partner":"4pna" + "partner":"8b16" }, { "sim":1.0, - "partner":"5ez8" + "partner":"5ez9" }, { "sim":1.0, - "partner":"7bim" + "partner":"7nff" }, { "sim":0.9664000273, @@ -256740,7 +257382,7 @@ }, { "sim":1.0, - "partner":"8b16" + "partner":"5eza" }, { "sim":1.0, @@ -256748,47 +257390,43 @@ }, { "sim":1.0, - "partner":"7nfg" + "partner":"7a1t" }, { "sim":1.0, - "partner":"7nfi" + "partner":"7bas" }, { "sim":1.0, "partner":"7nfl" }, - { - "sim":1.0, - "partner":"5ez9" - }, { "sim":0.9756000042, "partner":"7nfk" }, { "sim":1.0, - "partner":"7nfm" + "partner":"6zt1" }, { - "sim":1.0, - "partner":"7a1t" + "sim":0.9769999981, + "partner":"6yb0" }, { "sim":1.0, - "partner":"7bas" + "partner":"5ezc" }, { - "sim":0.9955000281, - "partner":"6g6d" + "sim":0.996900022, + "partner":"6g6a" }, { "sim":1.0, - "partner":"6zt1" + "partner":"6g6b" }, { - "sim":0.996900022, - "partner":"6g6a" + "sim":0.9955000281, + "partner":"6g6d" }, { "sim":0.993900001, @@ -256800,87 +257438,71 @@ }, { "sim":1.0, - "partner":"7nff" - }, - { - "sim":1.0, - "partner":"5ezc" - }, - { - "sim":1.0, - "partner":"6g6b" + "partner":"7nfn" }, { - "sim":1.0, - "partner":"7nfn" + "sim":0.9977999926, + "partner":"6g65" }, { "sim":1.0, - "partner":"5eza" + "partner":"6g6c" }, { "sim":0.9769999981, "partner":"6eik" }, { - "sim":0.9769999981, - "partner":"6yb0" - }, - { - "sim":0.977699995, - "partner":"7bau" + "sim":1.0, + "partner":"6g66" }, { "sim":1.0, - "partner":"6g6c" + "partner":"6g67" }, { "sim":1.0, "partner":"6xy0" }, { - "sim":0.9977999926, - "partner":"6g65" + "sim":1.0, + "partner":"6xxz" }, { - "sim":1.0, - "partner":"6g66" + "sim":0.977699995, + "partner":"7bau" }, { "sim":1.0, - "partner":"6g67" + "partner":"7nfp" }, { "sim":1.0, - "partner":"6g69" + "partner":"6g68" }, { "sim":1.0, - "partner":"6xxz" + "partner":"4dzn" }, { "sim":1.0, - "partner":"7nfp" + "partner":"6g69" }, { - "sim":0.9786999822, - "partner":"4dzl" + "sim":0.9575999975, + "partner":"5w0j" }, { - "sim":1.0, - "partner":"6g68" + "sim":0.9555000067, + "partner":"9gf2" }, { - "sim":1.0, - "partner":"4dzn" + "sim":0.9786999822, + "partner":"4dzl" }, { "sim":0.9886000156, "partner":"7boa" - }, - { - "sim":0.9575999975, - "partner":"5w0j" } ], "struct_thr_sim_natural":[ @@ -256894,7 +257516,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"6zt1" + "partner":"6yb2" }, "struct_max_sim_natural":[ @@ -256959,79 +257581,79 @@ ], "subtitle":"Crystal structure of an antiparallel five-helix coiled coil 5h2l_2.1-i9l", "tags":[ - "synthetic construct", - "alpha-helical bundle", - "de novo protein", "coiled coil", - "de novo" + "de novo", + "de novo protein", + "alpha-helical bundle", + "synthetic construct" ], "keywords":[ - "maximise", - "without", - "structural", - "reported", - "chains", + "designed", + "form", + "c", + "central", + "symmetry", + "design", + "cavities", "one", - "channels", + "hydrophobic", "another", - "helices", + "water", + "structural", + "show", + "hallmark", + "classes", + "lining", + "interest", + "structures", + "lumen", + "natural", + "maintained", + "around", + "side", + "surprising", "accessible", - "placement", - "cc", - "assemblies", + "assembly", + "aliphatic", + "residues", + "otherwise", "n", - "functionalised", - "ccs", - "barrels", "extended", + "without", + "hitherto", + "placement", + "dihedral", "accessed", - "nonetheless", - "adjust", - "designed", - "unobserved", + "ccs", + "folding", + "strategic", "subset", - "interest", + "cyclic", "surfaces", - "aliphatic", - "residues", - "maintained", - "strategic", - "nature", - "leading", - "classes", - "lining", - "central", - "hallmark", - "increasingly", "drive", - "show", - "lumen", - "design", - "wrap", - "structures", + "give", "protein", + "wrap", "buried", + "nature", "given", - "hydrophobic", - "natural", - "symmetry", - "dihedral", - "c", - "cavities", - "assembly", - "water", - "give", - "form", - "hitherto", - "side", - "folding", - "around", - "otherwise", "packing", - "cyclic", - "surprising", - "five", - "collapse" + "leading", + "cc", + "adjust", + "reported", + "channels", + "increasingly", + "nonetheless", + "helices", + "functionalised", + "assemblies", + "chains", + "collapse", + "unobserved", + "maximise", + "barrels", + "five" ], "release_date":"2018-10-17", "publication":"\"Maintaining and breaking symmetry in homomeric coiled-coil assemblies\", Nat Commun, 9, 4132-4132", @@ -257165,104 +257787,104 @@ ], "subtitle":"Crystal structure of the computationally designed tako8 protein in p42212", "tags":[ - "artificial protein", "de novo protein", - "wd40 proteins" + "wd40 proteins", + "artificial protein" ], "keywords":[ - "largest", - "evolution", - "many", - "architecture", - "ring", - "complexes", - "spaced", - "expressed", - "roles", - "abundant", - "carrying", - "homologue", - "complete", - "find", - "versatile", - "compensating", - "allowed", + "made", + "wd40", + "subfamily", "redesign", - "computationally", "owing", - "duplication", - "ika2", + "spaced", + "complexes", + "single", + "ika4", + "families", + "roles", + "subunit", + "folding", + "symmetrical", + "protein", + "study", + "ika8", + "cellular", + "polypeptides", "intrinsic", + "two", + "variety", + "applications", "adapt", - "called", - "proteins", - "employed", - "models", - "neighbouring", - "ika8", + "stable", "involved", - "rings", - "bionanotechnology", - "processes", - "inside", - "evolutionary", - "often", - "made", - "wd40", - "assemble", - "charges", - "symmetrical", - "structures", + "subdomains", "perfectly", - "solution", - "assembly", - "cellular", - "fusion", - "form", - "platform", - "history", - "blades", - "propeller", - "per", + "ika2", "respectively", - "ika4", - "families", - "four", - "tako8", - "artificial", - "may", - "closely", - "subfamily", - "activity", - "applications", - "negative", - "surface", - "vital", - "subdomains", - "diversification", - "one", - "also", + "computationally", + "ring", + "largest", "approach", - "study", - "wide", + "proteins", "acting", - "stable", - "single", - "fold", - "enzymatic", - "carry", "modular", - "different", - "subunit", + "architecture", + "may", "found", - "two", - "events", - "spontaneously", - "protein", - "variety", - "computational", - "polypeptides", - "folding", + "carrying", + "evolution", + "four", + "duplication", + "computational", + "vital", + "surface", + "propeller", + "compensating", + "fusion", + "homologue", + "different", + "processes", + "assembly", + "platform", + "tako8", + "called", + "fold", + "also", + "charges", + "carry", + "complete", + "wide", + "solution", + "spontaneously", + "diversification", + "neighbouring", + "versatile", + "history", + "per", + "evolutionary", + "form", + "employed", + "often", + "events", + "models", + "blades", + "many", + "one", + "structures", + "bionanotechnology", + "expressed", + "allowed", + "enzymatic", + "closely", + "inside", + "artificial", + "find", + "activity", + "abundant", + "negative", + "rings", + "assemble", "create" ], "release_date":"2018-11-28", @@ -257296,15 +257918,15 @@ "seq_thr_sim_designed":[ { "sim":649.0, - "partner":"6g6n" + "partner":"6y7n" }, { "sim":649.0, - "partner":"6y7p" + "partner":"6g6n" }, { "sim":649.0, - "partner":"6y7n" + "partner":"6y7p" }, { "sim":646.0, @@ -257408,21 +258030,13 @@ "sim":203.0, "partner":"2g99" }, - { - "sim":203.0, - "partner":"5vfc" - }, { "sim":203.0, "partner":"2g9a" }, { "sim":203.0, - "partner":"2h6k" - }, - { - "sim":203.0, - "partner":"5eap" + "partner":"5vfc" }, { "sim":203.0, @@ -257502,20 +258116,24 @@ }, { "sim":203.0, - "partner":"2h9n" + "partner":"2h6k" }, { "sim":203.0, - "partner":"6dai" + "partner":"5eap" }, { "sim":203.0, - "partner":"4gm8" + "partner":"6dai" }, { "sim":203.0, "partner":"6dak" }, + { + "sim":203.0, + "partner":"4gm8" + }, { "sim":203.0, "partner":"4gm3" @@ -257530,11 +258148,11 @@ }, { "sim":203.0, - "partner":"4gmb" + "partner":"6dar" }, { "sim":203.0, - "partner":"6dar" + "partner":"4gmb" }, { "sim":203.0, @@ -257552,6 +258170,10 @@ "sim":203.0, "partner":"2h9m" }, + { + "sim":203.0, + "partner":"2h9n" + }, { "sim":203.0, "partner":"5sxm" @@ -257614,11 +258236,11 @@ }, { "sim":203.0, - "partner":"2xl3" + "partner":"2xl2" }, { "sim":203.0, - "partner":"2xl2" + "partner":"2xl3" }, { "sim":203.0, @@ -257648,6 +258270,10 @@ "sim":191.0, "partner":"5yzv" }, + { + "sim":188.0, + "partner":"8rl2" + }, { "sim":182.0, "partner":"3v7d" @@ -257666,15 +258292,15 @@ }, { "sim":168.0, - "partner":"3jct" + "partner":"6ft6" }, { "sim":168.0, - "partner":"5jcs" + "partner":"3jct" }, { "sim":168.0, - "partner":"6ft6" + "partner":"5jcs" }, { "sim":168.0, @@ -257742,7 +258368,7 @@ }, { "sim":149.0, - "partner":"5ukk" + "partner":"8wgb" }, { "sim":149.0, @@ -257766,23 +258392,23 @@ }, { "sim":149.0, - "partner":"5he2" + "partner":"6g79" }, { "sim":149.0, - "partner":"6g79" + "partner":"5he2" }, { "sim":149.0, - "partner":"8wgb" + "partner":"5he3" }, { "sim":149.0, - "partner":"5he3" + "partner":"5ukk" }, { "sim":149.0, - "partner":"4kfm" + "partner":"8k4s" }, { "sim":149.0, @@ -257794,27 +258420,31 @@ }, { "sim":149.0, - "partner":"8k4s" + "partner":"8p15" }, { "sim":149.0, - "partner":"1gg2" + "partner":"8vve" }, { "sim":149.0, - "partner":"3pvu" + "partner":"8vvf" }, { "sim":149.0, - "partner":"4pnk" + "partner":"6c2y" }, { "sim":149.0, - "partner":"6c2y" + "partner":"8zjg" }, { "sim":149.0, - "partner":"8p12" + "partner":"3pvu" + }, + { + "sim":149.0, + "partner":"4pnk" }, { "sim":149.0, @@ -257830,7 +258460,11 @@ }, { "sim":149.0, - "partner":"1gp2" + "partner":"8vvg" + }, + { + "sim":149.0, + "partner":"1gg2" }, { "sim":149.0, @@ -257850,7 +258484,7 @@ }, { "sim":149.0, - "partner":"8p13" + "partner":"1gp2" }, { "sim":149.0, @@ -257868,6 +258502,14 @@ "sim":149.0, "partner":"3pvw" }, + { + "sim":149.0, + "partner":"8p12" + }, + { + "sim":149.0, + "partner":"8xqe" + }, { "sim":149.0, "partner":"3krw" @@ -257876,13 +258518,25 @@ "sim":149.0, "partner":"5wg5" }, + { + "sim":149.0, + "partner":"8z7j" + }, { "sim":149.0, "partner":"3krx" }, { "sim":149.0, - "partner":"8p15" + "partner":"8p13" + }, + { + "sim":149.0, + "partner":"8xqf" + }, + { + "sim":149.0, + "partner":"4kfm" }, { "sim":149.0, @@ -257906,7 +258560,7 @@ }, { "sim":149.0, - "partner":"6d9h" + "partner":"8xx3" }, { "sim":149.0, @@ -257916,6 +258570,18 @@ "sim":149.0, "partner":"6e3y" }, + { + "sim":149.0, + "partner":"8xx7" + }, + { + "sim":149.0, + "partner":"8xwv" + }, + { + "sim":149.0, + "partner":"8xxh" + }, { "sim":149.0, "partner":"6b3j" @@ -257924,6 +258590,26 @@ "sim":149.0, "partner":"8tyw" }, + { + "sim":149.0, + "partner":"8jzp" + }, + { + "sim":149.0, + "partner":"8xxx" + }, + { + "sim":149.0, + "partner":"8xxr" + }, + { + "sim":149.0, + "partner":"6d9h" + }, + { + "sim":149.0, + "partner":"8xx6" + }, { "sim":149.0, "partner":"5vai" @@ -257944,10 +258630,22 @@ "sim":149.0, "partner":"8rql" }, + { + "sim":149.0, + "partner":"8zfz" + }, { "sim":149.0, "partner":"8vhf" }, + { + "sim":149.0, + "partner":"8wwi" + }, + { + "sim":149.0, + "partner":"8wwj" + }, { "sim":149.0, "partner":"8wwk" @@ -257970,11 +258668,7 @@ }, { "sim":149.0, - "partner":"8wwi" - }, - { - "sim":149.0, - "partner":"8wwj" + "partner":"8jsr" }, { "sim":149.0, @@ -257998,11 +258692,11 @@ }, { "sim":147.0, - "partner":"1got" + "partner":"2trc" }, { "sim":147.0, - "partner":"2trc" + "partner":"1got" }, { "sim":147.0, @@ -258304,22 +258998,6 @@ "sim":121.0, "partner":"4v92" }, - { - "sim":121.0, - "partner":"4u4q" - }, - { - "sim":121.0, - "partner":"5obm" - }, - { - "sim":121.0, - "partner":"4u4r" - }, - { - "sim":121.0, - "partner":"5tgm" - }, { "sim":121.0, "partner":"4u6f" @@ -258336,6 +259014,10 @@ "sim":121.0, "partner":"4uer" }, + { + "sim":121.0, + "partner":"6gqv" + }, { "sim":121.0, "partner":"4u4u" @@ -258346,7 +259028,7 @@ }, { "sim":121.0, - "partner":"6gqv" + "partner":"5tgm" }, { "sim":121.0, @@ -258368,6 +259050,10 @@ "sim":121.0, "partner":"5ndv" }, + { + "sim":121.0, + "partner":"6gq1" + }, { "sim":121.0, "partner":"5ndw" @@ -258382,7 +259068,7 @@ }, { "sim":121.0, - "partner":"6gq1" + "partner":"6gqb" }, { "sim":121.0, @@ -258396,10 +259082,6 @@ "sim":121.0, "partner":"5dgv" }, - { - "sim":121.0, - "partner":"6gqb" - }, { "sim":121.0, "partner":"4u50" @@ -258466,15 +259148,15 @@ }, { "sim":121.0, - "partner":"3j6y" + "partner":"4u4q" }, { "sim":121.0, - "partner":"4v8y" + "partner":"5obm" }, { "sim":121.0, - "partner":"5juo" + "partner":"4u4r" }, { "sim":121.0, @@ -258490,7 +259172,7 @@ }, { "sim":121.0, - "partner":"8p4v" + "partner":"3j78" }, { "sim":121.0, @@ -258498,47 +259180,47 @@ }, { "sim":121.0, - "partner":"8t3a" + "partner":"3rfg" }, { "sim":121.0, - "partner":"8t30" + "partner":"5juu" }, { "sim":121.0, - "partner":"3j78" + "partner":"8t3a" }, { "sim":121.0, - "partner":"3rfg" + "partner":"8t30" }, { "sim":121.0, - "partner":"5juu" + "partner":"3j6x" }, { "sim":121.0, - "partner":"8t3c" + "partner":"3rfh" }, { "sim":121.0, - "partner":"3j6x" + "partner":"8t3c" }, { "sim":121.0, - "partner":"3rfh" + "partner":"4v88" }, { "sim":121.0, - "partner":"8t3e" + "partner":"8p4v" }, { "sim":121.0, - "partner":"4v88" + "partner":"4v7r" }, { "sim":121.0, - "partner":"4v7r" + "partner":"8t3e" }, { "sim":121.0, @@ -258554,11 +259236,11 @@ }, { "sim":121.0, - "partner":"8p9a" + "partner":"4v8z" }, { "sim":121.0, - "partner":"4v8z" + "partner":"3j77" }, { "sim":121.0, @@ -258566,11 +259248,11 @@ }, { "sim":121.0, - "partner":"3j77" + "partner":"5jut" }, { "sim":121.0, - "partner":"5jut" + "partner":"6fai" }, { "sim":121.0, @@ -258578,12 +259260,24 @@ }, { "sim":121.0, - "partner":"6fai" + "partner":"8p9a" + }, + { + "sim":121.0, + "partner":"3j6y" + }, + { + "sim":121.0, + "partner":"4v8y" }, { "sim":121.0, "partner":"8t3b" }, + { + "sim":121.0, + "partner":"5juo" + }, { "sim":121.0, "partner":"8t3d" @@ -258606,11 +259300,11 @@ }, { "sim":120.0, - "partner":"8ut0" + "partner":"8uti" }, { "sim":120.0, - "partner":"8uti" + "partner":"8ut0" }, { "sim":120.0, @@ -258696,22 +259390,10 @@ "sim":112.0, "partner":"4aow" }, - { - "sim":111.0, - "partner":"6fec" - }, - { - "sim":111.0, - "partner":"6mtb" - }, { "sim":111.0, "partner":"3jaj" }, - { - "sim":111.0, - "partner":"8ukb" - }, { "sim":111.0, "partner":"6mtd" @@ -258726,12 +259408,16 @@ }, { "sim":111.0, - "partner":"3jah" + "partner":"8ukb" }, { "sim":111.0, "partner":"6mtc" }, + { + "sim":111.0, + "partner":"3jah" + }, { "sim":111.0, "partner":"6mte" @@ -258746,11 +259432,11 @@ }, { "sim":111.0, - "partner":"5lzv" + "partner":"6fec" }, { "sim":111.0, - "partner":"4kzx" + "partner":"6mtb" }, { "sim":111.0, @@ -258794,27 +259480,31 @@ }, { "sim":111.0, - "partner":"5lzu" + "partner":"6hcm" }, { "sim":111.0, - "partner":"6hcm" + "partner":"5lzu" }, { "sim":111.0, "partner":"5lks" }, + { + "sim":111.0, + "partner":"6g18" + }, { "sim":111.0, "partner":"5lzx" }, { "sim":111.0, - "partner":"8vft" + "partner":"6g51" }, { "sim":111.0, - "partner":"6g18" + "partner":"6hcq" }, { "sim":111.0, @@ -258826,27 +259516,27 @@ }, { "sim":111.0, - "partner":"6g51" + "partner":"8vft" }, { "sim":111.0, - "partner":"6hcq" + "partner":"5flx" }, { "sim":111.0, - "partner":"5flx" + "partner":"6d90" }, { "sim":111.0, - "partner":"5lzt" + "partner":"6hcj" }, { "sim":111.0, - "partner":"6d90" + "partner":"5lzt" }, { "sim":111.0, - "partner":"6hcj" + "partner":"6d9j" }, { "sim":111.0, @@ -258854,19 +259544,19 @@ }, { "sim":111.0, - "partner":"5lzw" + "partner":"6g5h" }, { "sim":111.0, - "partner":"5t2c" + "partner":"5lzw" }, { "sim":111.0, - "partner":"6d9j" + "partner":"5t2c" }, { "sim":111.0, - "partner":"6g5h" + "partner":"6g5i" }, { "sim":111.0, @@ -258874,15 +259564,15 @@ }, { "sim":111.0, - "partner":"6g5i" + "partner":"4d5l" }, { "sim":111.0, - "partner":"4d5l" + "partner":"5lzz" }, { "sim":111.0, - "partner":"5lzz" + "partner":"6g53" }, { "sim":111.0, @@ -258894,16 +259584,20 @@ }, { "sim":111.0, - "partner":"6g53" + "partner":"5lzv" }, { "sim":111.0, - "partner":"5vh9" + "partner":"4kzx" }, { "sim":111.0, "partner":"5vlj" }, + { + "sim":111.0, + "partner":"5vh9" + }, { "sim":111.0, "partner":"5wve" @@ -258974,23 +259668,23 @@ }, { "sim":94.0, - "partner":"3jam" + "partner":"3j80" }, { "sim":94.0, - "partner":"3jap" + "partner":"3j81" }, { "sim":94.0, - "partner":"3j80" + "partner":"8s8k" }, { "sim":94.0, - "partner":"3j81" + "partner":"3jam" }, { "sim":94.0, - "partner":"8s8k" + "partner":"3jap" }, { "sim":94.0, @@ -259026,19 +259720,19 @@ }, { "sim":93.0, - "partner":"2xu7" + "partner":"6g16" }, { "sim":93.0, - "partner":"6g16" + "partner":"8vml" }, { "sim":93.0, - "partner":"5fxy" + "partner":"6c24" }, { "sim":93.0, - "partner":"6c24" + "partner":"5fxy" }, { "sim":93.0, @@ -259048,10 +259742,18 @@ "sim":93.0, "partner":"4pby" }, + { + "sim":93.0, + "partner":"8vmi" + }, { "sim":93.0, "partner":"4pbz" }, + { + "sim":93.0, + "partner":"8vnv" + }, { "sim":93.0, "partner":"4pc0" @@ -259060,10 +259762,18 @@ "sim":93.0, "partner":"6c23" }, + { + "sim":93.0, + "partner":"8vnz" + }, { "sim":93.0, "partner":"3gfc" }, + { + "sim":93.0, + "partner":"2xu7" + }, { "sim":93.0, "partner":"6bw3" @@ -259094,11 +259804,11 @@ }, { "sim":93.0, - "partner":"5xxq" + "partner":"5y1u" }, { "sim":93.0, - "partner":"5y1u" + "partner":"5xxq" }, { "sim":92.0, @@ -259108,17 +259818,13 @@ "sim":92.0, "partner":"4xyi" }, - { - "sim":90.0, - "partner":"4v5o" - }, { "sim":90.0, "partner":"4bts" }, { - "sim":89.0, - "partner":"5flc" + "sim":90.0, + "partner":"4v5o" }, { "sim":89.0, @@ -259162,12 +259868,16 @@ }, { "sim":89.0, - "partner":"5wbu" + "partner":"5flc" }, { "sim":89.0, "partner":"5wby" }, + { + "sim":89.0, + "partner":"5wbu" + }, { "sim":89.0, "partner":"5igq" @@ -259254,11 +259964,11 @@ }, { "sim":75.0, - "partner":"2aq5" + "partner":"2b4e" }, { "sim":75.0, - "partner":"2b4e" + "partner":"2aq5" }, { "sim":74.0, @@ -259266,11 +259976,11 @@ }, { "sim":74.0, - "partner":"1gxr" + "partner":"2ce8" }, { "sim":74.0, - "partner":"2ce8" + "partner":"1gxr" }, { "sim":74.0, @@ -259306,11 +260016,11 @@ }, { "sim":71.0, - "partner":"1pev" + "partner":"1nr0" }, { "sim":71.0, - "partner":"1nr0" + "partner":"1pev" }, { "sim":70.0, @@ -259348,14 +260058,6 @@ "sim":61.0, "partner":"3mmy" }, - { - "sim":60.0, - "partner":"5m5g" - }, - { - "sim":60.0, - "partner":"5wfd" - }, { "sim":60.0, "partner":"5bjs" @@ -259389,16 +260091,20 @@ "partner":"5wfc" }, { - "sim":59.0, - "partner":"6ckc" + "sim":60.0, + "partner":"5m5g" + }, + { + "sim":60.0, + "partner":"5wfd" }, { "sim":59.0, - "partner":"4gqb" + "partner":"6ckc" }, { "sim":59.0, - "partner":"4x63" + "partner":"4gqb" }, { "sim":59.0, @@ -259428,6 +260134,10 @@ "sim":59.0, "partner":"5emm" }, + { + "sim":59.0, + "partner":"4x63" + }, { "sim":59.0, "partner":"5fa5" @@ -259472,7 +260182,7 @@ ], "seq_max_sim_designed":{ "sim":649.0, - "partner":"6g6n" + "partner":"6y7n" }, "seq_max_sim_natural":{ "sim":323.0, @@ -259554,104 +260264,104 @@ ], "subtitle":"Crystal structure of the computationally designed tako8 protein in c2", "tags":[ - "artificial protein", "de novo protein", - "wd40 proteins" + "wd40 proteins", + "artificial protein" ], "keywords":[ - "largest", - "evolution", - "many", - "architecture", - "ring", - "complexes", - "spaced", - "expressed", - "roles", - "abundant", - "carrying", - "homologue", - "complete", - "find", - "versatile", - "compensating", - "allowed", + "made", + "wd40", + "subfamily", "redesign", - "computationally", "owing", - "duplication", - "ika2", + "spaced", + "complexes", + "single", + "ika4", + "families", + "roles", + "subunit", + "folding", + "symmetrical", + "protein", + "study", + "ika8", + "cellular", + "polypeptides", "intrinsic", + "two", + "variety", + "applications", "adapt", - "called", - "proteins", - "employed", - "models", - "neighbouring", - "ika8", + "stable", "involved", - "rings", - "bionanotechnology", - "processes", - "inside", - "evolutionary", - "often", - "made", - "wd40", - "assemble", - "charges", - "symmetrical", - "structures", + "subdomains", "perfectly", - "solution", - "assembly", - "cellular", + "ika2", + "respectively", + "computationally", + "ring", + "largest", + "approach", + "proteins", + "acting", + "modular", + "architecture", + "may", + "found", + "carrying", + "evolution", + "four", + "duplication", + "computational", + "vital", + "surface", + "propeller", + "compensating", "fusion", - "form", + "homologue", + "different", + "processes", + "assembly", "platform", + "tako8", + "called", + "fold", + "also", + "charges", + "carry", + "complete", + "wide", + "solution", + "spontaneously", + "diversification", + "neighbouring", + "versatile", "history", - "blades", - "propeller", "per", - "respectively", - "ika4", - "families", - "four", - "tako8", - "artificial", - "may", + "evolutionary", + "form", + "employed", + "often", + "events", + "models", + "blades", + "many", + "one", + "structures", + "bionanotechnology", + "expressed", + "allowed", + "enzymatic", "closely", - "subfamily", + "inside", + "artificial", + "find", "activity", - "applications", + "abundant", "negative", - "surface", - "vital", - "subdomains", - "diversification", - "one", - "also", - "approach", - "study", - "wide", - "acting", - "stable", - "single", - "fold", - "enzymatic", - "carry", - "modular", - "different", - "subunit", - "found", - "two", - "events", - "spontaneously", - "protein", - "variety", - "computational", - "polypeptides", - "folding", + "rings", + "assemble", "create" ], "release_date":"2018-11-28", @@ -259685,7 +260395,7 @@ "seq_thr_sim_designed":[ { "sim":649.0, - "partner":"6y7p" + "partner":"6g6m" }, { "sim":649.0, @@ -259693,7 +260403,7 @@ }, { "sim":649.0, - "partner":"6g6m" + "partner":"6y7p" }, { "sim":646.0, @@ -259797,21 +260507,13 @@ "sim":203.0, "partner":"2g99" }, - { - "sim":203.0, - "partner":"5vfc" - }, { "sim":203.0, "partner":"2g9a" }, { "sim":203.0, - "partner":"2h6k" - }, - { - "sim":203.0, - "partner":"5eap" + "partner":"5vfc" }, { "sim":203.0, @@ -259891,20 +260593,24 @@ }, { "sim":203.0, - "partner":"2h9n" + "partner":"2h6k" }, { "sim":203.0, - "partner":"6dai" + "partner":"5eap" }, { "sim":203.0, - "partner":"4gm8" + "partner":"6dai" }, { "sim":203.0, "partner":"6dak" }, + { + "sim":203.0, + "partner":"4gm8" + }, { "sim":203.0, "partner":"4gm3" @@ -259919,11 +260625,11 @@ }, { "sim":203.0, - "partner":"4gmb" + "partner":"6dar" }, { "sim":203.0, - "partner":"6dar" + "partner":"4gmb" }, { "sim":203.0, @@ -259941,6 +260647,10 @@ "sim":203.0, "partner":"2h9m" }, + { + "sim":203.0, + "partner":"2h9n" + }, { "sim":203.0, "partner":"5sxm" @@ -260003,11 +260713,11 @@ }, { "sim":203.0, - "partner":"2xl3" + "partner":"2xl2" }, { "sim":203.0, - "partner":"2xl2" + "partner":"2xl3" }, { "sim":203.0, @@ -260037,6 +260747,10 @@ "sim":191.0, "partner":"5yzv" }, + { + "sim":188.0, + "partner":"8rl2" + }, { "sim":182.0, "partner":"3v7d" @@ -260055,15 +260769,15 @@ }, { "sim":168.0, - "partner":"3jct" + "partner":"6ft6" }, { "sim":168.0, - "partner":"5jcs" + "partner":"3jct" }, { "sim":168.0, - "partner":"6ft6" + "partner":"5jcs" }, { "sim":168.0, @@ -260131,7 +260845,7 @@ }, { "sim":149.0, - "partner":"5ukk" + "partner":"8wgb" }, { "sim":149.0, @@ -260155,23 +260869,23 @@ }, { "sim":149.0, - "partner":"5he2" + "partner":"6g79" }, { "sim":149.0, - "partner":"6g79" + "partner":"5he2" }, { "sim":149.0, - "partner":"8wgb" + "partner":"5he3" }, { "sim":149.0, - "partner":"5he3" + "partner":"5ukk" }, { "sim":149.0, - "partner":"4kfm" + "partner":"8k4s" }, { "sim":149.0, @@ -260183,27 +260897,31 @@ }, { "sim":149.0, - "partner":"8k4s" + "partner":"8p15" }, { "sim":149.0, - "partner":"1gg2" + "partner":"8vve" }, { "sim":149.0, - "partner":"3pvu" + "partner":"8vvf" }, { "sim":149.0, - "partner":"4pnk" + "partner":"6c2y" }, { "sim":149.0, - "partner":"6c2y" + "partner":"8zjg" }, { "sim":149.0, - "partner":"8p12" + "partner":"3pvu" + }, + { + "sim":149.0, + "partner":"4pnk" }, { "sim":149.0, @@ -260219,7 +260937,11 @@ }, { "sim":149.0, - "partner":"1gp2" + "partner":"8vvg" + }, + { + "sim":149.0, + "partner":"1gg2" }, { "sim":149.0, @@ -260239,7 +260961,7 @@ }, { "sim":149.0, - "partner":"8p13" + "partner":"1gp2" }, { "sim":149.0, @@ -260257,6 +260979,14 @@ "sim":149.0, "partner":"3pvw" }, + { + "sim":149.0, + "partner":"8p12" + }, + { + "sim":149.0, + "partner":"8xqe" + }, { "sim":149.0, "partner":"3krw" @@ -260265,13 +260995,25 @@ "sim":149.0, "partner":"5wg5" }, + { + "sim":149.0, + "partner":"8z7j" + }, { "sim":149.0, "partner":"3krx" }, { "sim":149.0, - "partner":"8p15" + "partner":"8p13" + }, + { + "sim":149.0, + "partner":"8xqf" + }, + { + "sim":149.0, + "partner":"4kfm" }, { "sim":149.0, @@ -260295,7 +261037,7 @@ }, { "sim":149.0, - "partner":"6d9h" + "partner":"8xx3" }, { "sim":149.0, @@ -260305,6 +261047,18 @@ "sim":149.0, "partner":"6e3y" }, + { + "sim":149.0, + "partner":"8xx7" + }, + { + "sim":149.0, + "partner":"8xwv" + }, + { + "sim":149.0, + "partner":"8xxh" + }, { "sim":149.0, "partner":"6b3j" @@ -260313,6 +261067,26 @@ "sim":149.0, "partner":"8tyw" }, + { + "sim":149.0, + "partner":"8jzp" + }, + { + "sim":149.0, + "partner":"8xxx" + }, + { + "sim":149.0, + "partner":"8xxr" + }, + { + "sim":149.0, + "partner":"6d9h" + }, + { + "sim":149.0, + "partner":"8xx6" + }, { "sim":149.0, "partner":"5vai" @@ -260333,10 +261107,22 @@ "sim":149.0, "partner":"8rql" }, + { + "sim":149.0, + "partner":"8zfz" + }, { "sim":149.0, "partner":"8vhf" }, + { + "sim":149.0, + "partner":"8wwi" + }, + { + "sim":149.0, + "partner":"8wwj" + }, { "sim":149.0, "partner":"8wwk" @@ -260359,11 +261145,7 @@ }, { "sim":149.0, - "partner":"8wwi" - }, - { - "sim":149.0, - "partner":"8wwj" + "partner":"8jsr" }, { "sim":149.0, @@ -260387,11 +261169,11 @@ }, { "sim":147.0, - "partner":"1got" + "partner":"2trc" }, { "sim":147.0, - "partner":"2trc" + "partner":"1got" }, { "sim":147.0, @@ -260693,22 +261475,6 @@ "sim":121.0, "partner":"4v92" }, - { - "sim":121.0, - "partner":"4u4q" - }, - { - "sim":121.0, - "partner":"5obm" - }, - { - "sim":121.0, - "partner":"4u4r" - }, - { - "sim":121.0, - "partner":"5tgm" - }, { "sim":121.0, "partner":"4u6f" @@ -260725,6 +261491,10 @@ "sim":121.0, "partner":"4uer" }, + { + "sim":121.0, + "partner":"6gqv" + }, { "sim":121.0, "partner":"4u4u" @@ -260735,7 +261505,7 @@ }, { "sim":121.0, - "partner":"6gqv" + "partner":"5tgm" }, { "sim":121.0, @@ -260757,6 +261527,10 @@ "sim":121.0, "partner":"5ndv" }, + { + "sim":121.0, + "partner":"6gq1" + }, { "sim":121.0, "partner":"5ndw" @@ -260771,7 +261545,7 @@ }, { "sim":121.0, - "partner":"6gq1" + "partner":"6gqb" }, { "sim":121.0, @@ -260785,10 +261559,6 @@ "sim":121.0, "partner":"5dgv" }, - { - "sim":121.0, - "partner":"6gqb" - }, { "sim":121.0, "partner":"4u50" @@ -260855,15 +261625,15 @@ }, { "sim":121.0, - "partner":"3j6y" + "partner":"4u4q" }, { "sim":121.0, - "partner":"4v8y" + "partner":"5obm" }, { "sim":121.0, - "partner":"5juo" + "partner":"4u4r" }, { "sim":121.0, @@ -260879,7 +261649,7 @@ }, { "sim":121.0, - "partner":"8p4v" + "partner":"3j78" }, { "sim":121.0, @@ -260887,47 +261657,47 @@ }, { "sim":121.0, - "partner":"8t3a" + "partner":"3rfg" }, { "sim":121.0, - "partner":"8t30" + "partner":"5juu" }, { "sim":121.0, - "partner":"3j78" + "partner":"8t3a" }, { "sim":121.0, - "partner":"3rfg" + "partner":"8t30" }, { "sim":121.0, - "partner":"5juu" + "partner":"3j6x" }, { "sim":121.0, - "partner":"8t3c" + "partner":"3rfh" }, { "sim":121.0, - "partner":"3j6x" + "partner":"8t3c" }, { "sim":121.0, - "partner":"3rfh" + "partner":"4v88" }, { "sim":121.0, - "partner":"8t3e" + "partner":"8p4v" }, { "sim":121.0, - "partner":"4v88" + "partner":"4v7r" }, { "sim":121.0, - "partner":"4v7r" + "partner":"8t3e" }, { "sim":121.0, @@ -260943,11 +261713,11 @@ }, { "sim":121.0, - "partner":"8p9a" + "partner":"4v8z" }, { "sim":121.0, - "partner":"4v8z" + "partner":"3j77" }, { "sim":121.0, @@ -260955,11 +261725,11 @@ }, { "sim":121.0, - "partner":"3j77" + "partner":"5jut" }, { "sim":121.0, - "partner":"5jut" + "partner":"6fai" }, { "sim":121.0, @@ -260967,12 +261737,24 @@ }, { "sim":121.0, - "partner":"6fai" + "partner":"8p9a" + }, + { + "sim":121.0, + "partner":"3j6y" + }, + { + "sim":121.0, + "partner":"4v8y" }, { "sim":121.0, "partner":"8t3b" }, + { + "sim":121.0, + "partner":"5juo" + }, { "sim":121.0, "partner":"8t3d" @@ -260995,11 +261777,11 @@ }, { "sim":120.0, - "partner":"8ut0" + "partner":"8uti" }, { "sim":120.0, - "partner":"8uti" + "partner":"8ut0" }, { "sim":120.0, @@ -261085,22 +261867,10 @@ "sim":112.0, "partner":"4aow" }, - { - "sim":111.0, - "partner":"6fec" - }, - { - "sim":111.0, - "partner":"6mtb" - }, { "sim":111.0, "partner":"3jaj" }, - { - "sim":111.0, - "partner":"8ukb" - }, { "sim":111.0, "partner":"6mtd" @@ -261115,12 +261885,16 @@ }, { "sim":111.0, - "partner":"3jah" + "partner":"8ukb" }, { "sim":111.0, "partner":"6mtc" }, + { + "sim":111.0, + "partner":"3jah" + }, { "sim":111.0, "partner":"6mte" @@ -261135,11 +261909,11 @@ }, { "sim":111.0, - "partner":"5lzv" + "partner":"6fec" }, { "sim":111.0, - "partner":"4kzx" + "partner":"6mtb" }, { "sim":111.0, @@ -261183,27 +261957,31 @@ }, { "sim":111.0, - "partner":"5lzu" + "partner":"6hcm" }, { "sim":111.0, - "partner":"6hcm" + "partner":"5lzu" }, { "sim":111.0, "partner":"5lks" }, + { + "sim":111.0, + "partner":"6g18" + }, { "sim":111.0, "partner":"5lzx" }, { "sim":111.0, - "partner":"8vft" + "partner":"6g51" }, { "sim":111.0, - "partner":"6g18" + "partner":"6hcq" }, { "sim":111.0, @@ -261215,27 +261993,27 @@ }, { "sim":111.0, - "partner":"6g51" + "partner":"8vft" }, { "sim":111.0, - "partner":"6hcq" + "partner":"5flx" }, { "sim":111.0, - "partner":"5flx" + "partner":"6d90" }, { "sim":111.0, - "partner":"5lzt" + "partner":"6hcj" }, { "sim":111.0, - "partner":"6d90" + "partner":"5lzt" }, { "sim":111.0, - "partner":"6hcj" + "partner":"6d9j" }, { "sim":111.0, @@ -261243,19 +262021,19 @@ }, { "sim":111.0, - "partner":"5lzw" + "partner":"6g5h" }, { "sim":111.0, - "partner":"5t2c" + "partner":"5lzw" }, { "sim":111.0, - "partner":"6d9j" + "partner":"5t2c" }, { "sim":111.0, - "partner":"6g5h" + "partner":"6g5i" }, { "sim":111.0, @@ -261263,15 +262041,15 @@ }, { "sim":111.0, - "partner":"6g5i" + "partner":"4d5l" }, { "sim":111.0, - "partner":"4d5l" + "partner":"5lzz" }, { "sim":111.0, - "partner":"5lzz" + "partner":"6g53" }, { "sim":111.0, @@ -261283,16 +262061,20 @@ }, { "sim":111.0, - "partner":"6g53" + "partner":"5lzv" }, { "sim":111.0, - "partner":"5vh9" + "partner":"4kzx" }, { "sim":111.0, "partner":"5vlj" }, + { + "sim":111.0, + "partner":"5vh9" + }, { "sim":111.0, "partner":"5wve" @@ -261363,23 +262145,23 @@ }, { "sim":94.0, - "partner":"3jam" + "partner":"3j80" }, { "sim":94.0, - "partner":"3jap" + "partner":"3j81" }, { "sim":94.0, - "partner":"3j80" + "partner":"8s8k" }, { "sim":94.0, - "partner":"3j81" + "partner":"3jam" }, { "sim":94.0, - "partner":"8s8k" + "partner":"3jap" }, { "sim":94.0, @@ -261415,19 +262197,19 @@ }, { "sim":93.0, - "partner":"2xu7" + "partner":"6g16" }, { "sim":93.0, - "partner":"6g16" + "partner":"8vml" }, { "sim":93.0, - "partner":"5fxy" + "partner":"6c24" }, { "sim":93.0, - "partner":"6c24" + "partner":"5fxy" }, { "sim":93.0, @@ -261437,10 +262219,18 @@ "sim":93.0, "partner":"4pby" }, + { + "sim":93.0, + "partner":"8vmi" + }, { "sim":93.0, "partner":"4pbz" }, + { + "sim":93.0, + "partner":"8vnv" + }, { "sim":93.0, "partner":"4pc0" @@ -261449,10 +262239,18 @@ "sim":93.0, "partner":"6c23" }, + { + "sim":93.0, + "partner":"8vnz" + }, { "sim":93.0, "partner":"3gfc" }, + { + "sim":93.0, + "partner":"2xu7" + }, { "sim":93.0, "partner":"6bw3" @@ -261483,11 +262281,11 @@ }, { "sim":93.0, - "partner":"5xxq" + "partner":"5y1u" }, { "sim":93.0, - "partner":"5y1u" + "partner":"5xxq" }, { "sim":92.0, @@ -261497,17 +262295,13 @@ "sim":92.0, "partner":"4xyi" }, - { - "sim":90.0, - "partner":"4v5o" - }, { "sim":90.0, "partner":"4bts" }, { - "sim":89.0, - "partner":"5flc" + "sim":90.0, + "partner":"4v5o" }, { "sim":89.0, @@ -261551,12 +262345,16 @@ }, { "sim":89.0, - "partner":"5wbu" + "partner":"5flc" }, { "sim":89.0, "partner":"5wby" }, + { + "sim":89.0, + "partner":"5wbu" + }, { "sim":89.0, "partner":"5igq" @@ -261643,11 +262441,11 @@ }, { "sim":75.0, - "partner":"2aq5" + "partner":"2b4e" }, { "sim":75.0, - "partner":"2b4e" + "partner":"2aq5" }, { "sim":74.0, @@ -261655,11 +262453,11 @@ }, { "sim":74.0, - "partner":"1gxr" + "partner":"2ce8" }, { "sim":74.0, - "partner":"2ce8" + "partner":"1gxr" }, { "sim":74.0, @@ -261695,11 +262493,11 @@ }, { "sim":71.0, - "partner":"1pev" + "partner":"1nr0" }, { "sim":71.0, - "partner":"1nr0" + "partner":"1pev" }, { "sim":70.0, @@ -261737,14 +262535,6 @@ "sim":61.0, "partner":"3mmy" }, - { - "sim":60.0, - "partner":"5m5g" - }, - { - "sim":60.0, - "partner":"5wfd" - }, { "sim":60.0, "partner":"5bjs" @@ -261778,16 +262568,20 @@ "partner":"5wfc" }, { - "sim":59.0, - "partner":"6ckc" + "sim":60.0, + "partner":"5m5g" + }, + { + "sim":60.0, + "partner":"5wfd" }, { "sim":59.0, - "partner":"4gqb" + "partner":"6ckc" }, { "sim":59.0, - "partner":"4x63" + "partner":"4gqb" }, { "sim":59.0, @@ -261817,6 +262611,10 @@ "sim":59.0, "partner":"5emm" }, + { + "sim":59.0, + "partner":"4x63" + }, { "sim":59.0, "partner":"5fa5" @@ -261861,7 +262659,7 @@ ], "seq_max_sim_designed":{ "sim":649.0, - "partner":"6y7p" + "partner":"6g6m" }, "seq_max_sim_natural":{ "sim":323.0, @@ -261943,104 +262741,104 @@ ], "subtitle":"Crystal structure of the computationally designed ika8 protein: crystal packing no.1 in p63", "tags":[ - "artificial protein", "de novo protein", - "wd40 proteins" + "wd40 proteins", + "artificial protein" ], "keywords":[ - "largest", - "evolution", - "many", - "architecture", - "ring", - "complexes", - "spaced", - "expressed", - "roles", - "abundant", - "carrying", - "homologue", - "complete", - "find", - "versatile", - "compensating", - "allowed", + "made", + "wd40", + "subfamily", "redesign", - "computationally", "owing", - "duplication", - "ika2", + "spaced", + "complexes", + "single", + "ika4", + "families", + "roles", + "subunit", + "folding", + "symmetrical", + "protein", + "study", + "ika8", + "cellular", + "polypeptides", "intrinsic", + "two", + "variety", + "applications", "adapt", - "called", - "proteins", - "employed", - "models", - "neighbouring", - "ika8", + "stable", "involved", - "rings", - "bionanotechnology", - "processes", - "inside", - "evolutionary", - "often", - "made", - "wd40", - "assemble", - "charges", - "symmetrical", - "structures", + "subdomains", "perfectly", - "solution", - "assembly", - "cellular", + "ika2", + "respectively", + "computationally", + "ring", + "largest", + "approach", + "proteins", + "acting", + "modular", + "architecture", + "may", + "found", + "carrying", + "evolution", + "four", + "duplication", + "computational", + "vital", + "surface", + "propeller", + "compensating", "fusion", - "form", + "homologue", + "different", + "processes", + "assembly", "platform", + "tako8", + "called", + "fold", + "also", + "charges", + "carry", + "complete", + "wide", + "solution", + "spontaneously", + "diversification", + "neighbouring", + "versatile", "history", - "blades", - "propeller", "per", - "respectively", - "ika4", - "families", - "four", - "tako8", - "artificial", - "may", + "evolutionary", + "form", + "employed", + "often", + "events", + "models", + "blades", + "many", + "one", + "structures", + "bionanotechnology", + "expressed", + "allowed", + "enzymatic", "closely", - "subfamily", + "inside", + "artificial", + "find", "activity", - "applications", + "abundant", "negative", - "surface", - "vital", - "subdomains", - "diversification", - "one", - "also", - "approach", - "study", - "wide", - "acting", - "stable", - "single", - "fold", - "enzymatic", - "carry", - "modular", - "different", - "subunit", - "found", - "two", - "events", - "spontaneously", - "protein", - "variety", - "computational", - "polypeptides", - "folding", + "rings", + "assemble", "create" ], "release_date":"2018-11-28", @@ -262082,19 +262880,19 @@ }, { "sim":437.0, - "partner":"6g6n" + "partner":"6g6m" }, { "sim":437.0, - "partner":"6y7p" + "partner":"6y7n" }, { "sim":437.0, - "partner":"6y7n" + "partner":"6g6n" }, { "sim":437.0, - "partner":"6g6m" + "partner":"6y7p" }, { "sim":333.0, @@ -262167,16 +262965,16 @@ "partner":"4cy5" }, { - "sim":156.0, - "partner":"6byn" + "sim":161.0, + "partner":"8rl2" }, { "sim":156.0, - "partner":"2g99" + "partner":"6byn" }, { "sim":156.0, - "partner":"5vfc" + "partner":"2g99" }, { "sim":156.0, @@ -262184,11 +262982,7 @@ }, { "sim":156.0, - "partner":"2h6k" - }, - { - "sim":156.0, - "partner":"5eap" + "partner":"5vfc" }, { "sim":156.0, @@ -262268,20 +263062,24 @@ }, { "sim":156.0, - "partner":"2h9n" + "partner":"2h6k" }, { "sim":156.0, - "partner":"6dai" + "partner":"5eap" }, { "sim":156.0, - "partner":"4gm8" + "partner":"6dai" }, { "sim":156.0, "partner":"6dak" }, + { + "sim":156.0, + "partner":"4gm8" + }, { "sim":156.0, "partner":"4gm3" @@ -262296,11 +263094,11 @@ }, { "sim":156.0, - "partner":"4gmb" + "partner":"6dar" }, { "sim":156.0, - "partner":"6dar" + "partner":"4gmb" }, { "sim":156.0, @@ -262318,6 +263116,10 @@ "sim":156.0, "partner":"2h9m" }, + { + "sim":156.0, + "partner":"2h9n" + }, { "sim":156.0, "partner":"5sxm" @@ -262392,11 +263194,11 @@ }, { "sim":156.0, - "partner":"2xl3" + "partner":"2xl2" }, { "sim":156.0, - "partner":"2xl2" + "partner":"2xl3" }, { "sim":156.0, @@ -262452,15 +263254,15 @@ }, { "sim":131.0, - "partner":"3jct" + "partner":"6ft6" }, { "sim":131.0, - "partner":"5jcs" + "partner":"3jct" }, { "sim":131.0, - "partner":"6ft6" + "partner":"5jcs" }, { "sim":131.0, @@ -262494,22 +263296,10 @@ "sim":125.0, "partner":"4aow" }, - { - "sim":124.0, - "partner":"6fec" - }, - { - "sim":124.0, - "partner":"6mtb" - }, { "sim":124.0, "partner":"3jaj" }, - { - "sim":124.0, - "partner":"8ukb" - }, { "sim":124.0, "partner":"6mtd" @@ -262524,12 +263314,16 @@ }, { "sim":124.0, - "partner":"3jah" + "partner":"8ukb" }, { "sim":124.0, "partner":"6mtc" }, + { + "sim":124.0, + "partner":"3jah" + }, { "sim":124.0, "partner":"6mte" @@ -262544,11 +263338,11 @@ }, { "sim":124.0, - "partner":"5lzv" + "partner":"6fec" }, { "sim":124.0, - "partner":"4kzx" + "partner":"6mtb" }, { "sim":124.0, @@ -262592,27 +263386,31 @@ }, { "sim":124.0, - "partner":"5lzu" + "partner":"6hcm" }, { "sim":124.0, - "partner":"6hcm" + "partner":"5lzu" }, { "sim":124.0, "partner":"5lks" }, + { + "sim":124.0, + "partner":"6g18" + }, { "sim":124.0, "partner":"5lzx" }, { "sim":124.0, - "partner":"8vft" + "partner":"6g51" }, { "sim":124.0, - "partner":"6g18" + "partner":"6hcq" }, { "sim":124.0, @@ -262624,27 +263422,27 @@ }, { "sim":124.0, - "partner":"6g51" + "partner":"8vft" }, { "sim":124.0, - "partner":"6hcq" + "partner":"5flx" }, { "sim":124.0, - "partner":"5flx" + "partner":"6d90" }, { "sim":124.0, - "partner":"5lzt" + "partner":"6hcj" }, { "sim":124.0, - "partner":"6d90" + "partner":"5lzt" }, { "sim":124.0, - "partner":"6hcj" + "partner":"6d9j" }, { "sim":124.0, @@ -262652,19 +263450,19 @@ }, { "sim":124.0, - "partner":"5lzw" + "partner":"6g5h" }, { "sim":124.0, - "partner":"5t2c" + "partner":"5lzw" }, { "sim":124.0, - "partner":"6d9j" + "partner":"5t2c" }, { "sim":124.0, - "partner":"6g5h" + "partner":"6g5i" }, { "sim":124.0, @@ -262672,15 +263470,15 @@ }, { "sim":124.0, - "partner":"6g5i" + "partner":"4d5l" }, { "sim":124.0, - "partner":"4d5l" + "partner":"5lzz" }, { "sim":124.0, - "partner":"5lzz" + "partner":"6g53" }, { "sim":124.0, @@ -262692,7 +263490,11 @@ }, { "sim":124.0, - "partner":"6g53" + "partner":"5lzv" + }, + { + "sim":124.0, + "partner":"4kzx" }, { "sim":122.0, @@ -262742,10 +263544,22 @@ "sim":117.0, "partner":"3ow8" }, + { + "sim":117.0, + "partner":"8zfz" + }, { "sim":117.0, "partner":"8vhf" }, + { + "sim":117.0, + "partner":"8wwi" + }, + { + "sim":117.0, + "partner":"8wwj" + }, { "sim":117.0, "partner":"8wwk" @@ -262768,11 +263582,7 @@ }, { "sim":117.0, - "partner":"8wwi" - }, - { - "sim":117.0, - "partner":"8wwj" + "partner":"8jsr" }, { "sim":117.0, @@ -262792,7 +263602,7 @@ }, { "sim":116.0, - "partner":"5ukk" + "partner":"8wgb" }, { "sim":116.0, @@ -262816,23 +263626,23 @@ }, { "sim":116.0, - "partner":"5he2" + "partner":"6g79" }, { "sim":116.0, - "partner":"6g79" + "partner":"5he2" }, { "sim":116.0, - "partner":"8wgb" + "partner":"5he3" }, { "sim":116.0, - "partner":"5he3" + "partner":"5ukk" }, { "sim":116.0, - "partner":"4kfm" + "partner":"8k4s" }, { "sim":116.0, @@ -262844,27 +263654,31 @@ }, { "sim":116.0, - "partner":"8k4s" + "partner":"8p15" }, { "sim":116.0, - "partner":"1gg2" + "partner":"8vve" }, { "sim":116.0, - "partner":"3pvu" + "partner":"8vvf" }, { "sim":116.0, - "partner":"4pnk" + "partner":"6c2y" }, { "sim":116.0, - "partner":"6c2y" + "partner":"8zjg" }, { "sim":116.0, - "partner":"8p12" + "partner":"3pvu" + }, + { + "sim":116.0, + "partner":"4pnk" }, { "sim":116.0, @@ -262880,7 +263694,11 @@ }, { "sim":116.0, - "partner":"1gp2" + "partner":"8vvg" + }, + { + "sim":116.0, + "partner":"1gg2" }, { "sim":116.0, @@ -262900,7 +263718,7 @@ }, { "sim":116.0, - "partner":"8p13" + "partner":"1gp2" }, { "sim":116.0, @@ -262918,6 +263736,14 @@ "sim":116.0, "partner":"3pvw" }, + { + "sim":116.0, + "partner":"8p12" + }, + { + "sim":116.0, + "partner":"8xqe" + }, { "sim":116.0, "partner":"3krw" @@ -262926,13 +263752,25 @@ "sim":116.0, "partner":"5wg5" }, + { + "sim":116.0, + "partner":"8z7j" + }, { "sim":116.0, "partner":"3krx" }, { "sim":116.0, - "partner":"8p15" + "partner":"8p13" + }, + { + "sim":116.0, + "partner":"8xqf" + }, + { + "sim":116.0, + "partner":"4kfm" }, { "sim":116.0, @@ -262956,7 +263794,7 @@ }, { "sim":116.0, - "partner":"6d9h" + "partner":"8xx3" }, { "sim":116.0, @@ -262966,6 +263804,18 @@ "sim":116.0, "partner":"6e3y" }, + { + "sim":116.0, + "partner":"8xx7" + }, + { + "sim":116.0, + "partner":"8xwv" + }, + { + "sim":116.0, + "partner":"8xxh" + }, { "sim":116.0, "partner":"6b3j" @@ -262974,6 +263824,26 @@ "sim":116.0, "partner":"8tyw" }, + { + "sim":116.0, + "partner":"8jzp" + }, + { + "sim":116.0, + "partner":"8xxx" + }, + { + "sim":116.0, + "partner":"8xxr" + }, + { + "sim":116.0, + "partner":"6d9h" + }, + { + "sim":116.0, + "partner":"8xx6" + }, { "sim":116.0, "partner":"5vai" @@ -263000,11 +263870,11 @@ }, { "sim":115.0, - "partner":"1got" + "partner":"2trc" }, { "sim":115.0, - "partner":"2trc" + "partner":"1got" }, { "sim":115.0, @@ -263028,15 +263898,15 @@ }, { "sim":113.0, - "partner":"5z57" + "partner":"5z56" }, { "sim":113.0, - "partner":"5z56" + "partner":"5xjc" }, { "sim":113.0, - "partner":"5xjc" + "partner":"6ff4" }, { "sim":113.0, @@ -263048,7 +263918,7 @@ }, { "sim":113.0, - "partner":"6ff4" + "partner":"5z57" }, { "sim":113.0, @@ -263170,33 +264040,17 @@ "sim":108.0, "partner":"4v7h" }, - { - "sim":107.0, - "partner":"8ut0" - }, { "sim":107.0, "partner":"8uti" }, { "sim":107.0, - "partner":"4v92" - }, - { - "sim":107.0, - "partner":"4u4q" - }, - { - "sim":107.0, - "partner":"5obm" - }, - { - "sim":107.0, - "partner":"4u4r" + "partner":"8ut0" }, { "sim":107.0, - "partner":"5tgm" + "partner":"4v92" }, { "sim":107.0, @@ -263214,6 +264068,10 @@ "sim":107.0, "partner":"4uer" }, + { + "sim":107.0, + "partner":"6gqv" + }, { "sim":107.0, "partner":"4u4u" @@ -263224,7 +264082,7 @@ }, { "sim":107.0, - "partner":"6gqv" + "partner":"5tgm" }, { "sim":107.0, @@ -263246,6 +264104,10 @@ "sim":107.0, "partner":"5ndv" }, + { + "sim":107.0, + "partner":"6gq1" + }, { "sim":107.0, "partner":"5ndw" @@ -263260,7 +264122,7 @@ }, { "sim":107.0, - "partner":"6gq1" + "partner":"6gqb" }, { "sim":107.0, @@ -263274,10 +264136,6 @@ "sim":107.0, "partner":"5dgv" }, - { - "sim":107.0, - "partner":"6gqb" - }, { "sim":107.0, "partner":"4u50" @@ -263344,15 +264202,15 @@ }, { "sim":107.0, - "partner":"3j6y" + "partner":"4u4q" }, { "sim":107.0, - "partner":"4v8y" + "partner":"5obm" }, { "sim":107.0, - "partner":"5juo" + "partner":"4u4r" }, { "sim":107.0, @@ -263368,7 +264226,7 @@ }, { "sim":107.0, - "partner":"8p4v" + "partner":"3j78" }, { "sim":107.0, @@ -263376,19 +264234,19 @@ }, { "sim":107.0, - "partner":"8t3a" + "partner":"5juu" }, { "sim":107.0, - "partner":"8t30" + "partner":"8t3a" }, { "sim":107.0, - "partner":"3j78" + "partner":"8t30" }, { "sim":107.0, - "partner":"5juu" + "partner":"3j6x" }, { "sim":107.0, @@ -263396,19 +264254,19 @@ }, { "sim":107.0, - "partner":"3j6x" + "partner":"4v88" }, { "sim":107.0, - "partner":"8t3e" + "partner":"8p4v" }, { "sim":107.0, - "partner":"4v88" + "partner":"4v7r" }, { "sim":107.0, - "partner":"4v7r" + "partner":"8t3e" }, { "sim":107.0, @@ -263424,11 +264282,11 @@ }, { "sim":107.0, - "partner":"8p9a" + "partner":"4v8z" }, { "sim":107.0, - "partner":"4v8z" + "partner":"3j77" }, { "sim":107.0, @@ -263436,11 +264294,11 @@ }, { "sim":107.0, - "partner":"3j77" + "partner":"5jut" }, { "sim":107.0, - "partner":"5jut" + "partner":"6fai" }, { "sim":107.0, @@ -263448,12 +264306,24 @@ }, { "sim":107.0, - "partner":"6fai" + "partner":"8p9a" + }, + { + "sim":107.0, + "partner":"3j6y" + }, + { + "sim":107.0, + "partner":"4v8y" }, { "sim":107.0, "partner":"8t3b" }, + { + "sim":107.0, + "partner":"5juo" + }, { "sim":107.0, "partner":"8t3d" @@ -263486,10 +264356,6 @@ "sim":106.0, "partner":"6hqa" }, - { - "sim":106.0, - "partner":"5nzv" - }, { "sim":106.0, "partner":"5nzt" @@ -263526,6 +264392,10 @@ "sim":106.0, "partner":"5a1w" }, + { + "sim":106.0, + "partner":"5nzv" + }, { "sim":106.0, "partner":"3sfz" @@ -263696,19 +264566,19 @@ }, { "sim":91.0, - "partner":"5khr" + "partner":"5khu" }, { "sim":91.0, - "partner":"6f0x" + "partner":"5g04" }, { "sim":91.0, - "partner":"5khu" + "partner":"6f0x" }, { "sim":91.0, - "partner":"5g04" + "partner":"5khr" }, { "sim":87.0, @@ -263724,23 +264594,23 @@ }, { "sim":85.0, - "partner":"3jam" + "partner":"3j80" }, { "sim":85.0, - "partner":"3jap" + "partner":"3j81" }, { "sim":85.0, - "partner":"3j80" + "partner":"8s8k" }, { "sim":85.0, - "partner":"3j81" + "partner":"3jam" }, { "sim":85.0, - "partner":"8s8k" + "partner":"3jap" }, { "sim":85.0, @@ -263796,11 +264666,11 @@ }, { "sim":80.0, - "partner":"4v5o" + "partner":"4bts" }, { "sim":80.0, - "partner":"4bts" + "partner":"4v5o" }, { "sim":79.0, @@ -263892,11 +264762,11 @@ }, { "sim":70.0, - "partner":"5vh9" + "partner":"5vlj" }, { "sim":70.0, - "partner":"5vlj" + "partner":"5vh9" }, { "sim":70.0, @@ -263932,11 +264802,11 @@ }, { "sim":66.0, - "partner":"1gxr" + "partner":"2ce8" }, { "sim":66.0, - "partner":"2ce8" + "partner":"1gxr" }, { "sim":66.0, @@ -263970,10 +264840,6 @@ "sim":66.0, "partner":"3c9c" }, - { - "sim":65.0, - "partner":"5flc" - }, { "sim":65.0, "partner":"4jsv" @@ -264016,12 +264882,16 @@ }, { "sim":65.0, - "partner":"5wbu" + "partner":"5flc" }, { "sim":65.0, "partner":"5wby" }, + { + "sim":65.0, + "partner":"5wbu" + }, { "sim":65.0, "partner":"1pgu" @@ -264032,19 +264902,19 @@ }, { "sim":64.0, - "partner":"2xu7" + "partner":"6g16" }, { "sim":64.0, - "partner":"6g16" + "partner":"8vml" }, { "sim":64.0, - "partner":"5fxy" + "partner":"6c24" }, { "sim":64.0, - "partner":"6c24" + "partner":"5fxy" }, { "sim":64.0, @@ -264054,10 +264924,18 @@ "sim":64.0, "partner":"4pby" }, + { + "sim":64.0, + "partner":"8vmi" + }, { "sim":64.0, "partner":"4pbz" }, + { + "sim":64.0, + "partner":"8vnv" + }, { "sim":64.0, "partner":"4pc0" @@ -264066,10 +264944,18 @@ "sim":64.0, "partner":"6c23" }, + { + "sim":64.0, + "partner":"8vnz" + }, { "sim":64.0, "partner":"3gfc" }, + { + "sim":64.0, + "partner":"2xu7" + }, { "sim":64.0, "partner":"6bw3" @@ -264100,27 +264986,27 @@ }, { "sim":64.0, - "partner":"5xxq" + "partner":"5y1u" }, { "sim":64.0, - "partner":"5y1u" + "partner":"5xxq" }, { "sim":61.0, - "partner":"2aq5" + "partner":"2b4e" }, { "sim":61.0, - "partner":"2b4e" + "partner":"2aq5" }, { "sim":60.0, - "partner":"1pev" + "partner":"1nr0" }, { "sim":60.0, - "partner":"1nr0" + "partner":"1pev" }, { "sim":58.0, @@ -264264,104 +265150,104 @@ ], "subtitle":"Crystal structure of the computationally designed ika8 protein: crystal packing no.2 in p63", "tags":[ - "artificial protein", "de novo protein", - "wd40 proteins" + "wd40 proteins", + "artificial protein" ], "keywords":[ - "largest", - "evolution", - "many", - "architecture", - "ring", - "complexes", - "spaced", - "expressed", - "roles", - "abundant", - "carrying", - "homologue", - "complete", - "find", - "versatile", - "compensating", - "allowed", + "made", + "wd40", + "subfamily", "redesign", - "computationally", "owing", - "duplication", - "ika2", + "spaced", + "complexes", + "single", + "ika4", + "families", + "roles", + "subunit", + "folding", + "symmetrical", + "protein", + "study", + "ika8", + "cellular", + "polypeptides", "intrinsic", + "two", + "variety", + "applications", "adapt", - "called", - "proteins", - "employed", - "models", - "neighbouring", - "ika8", + "stable", "involved", - "rings", - "bionanotechnology", - "processes", - "inside", - "evolutionary", - "often", - "made", - "wd40", - "assemble", - "charges", - "symmetrical", - "structures", + "subdomains", "perfectly", - "solution", - "assembly", - "cellular", + "ika2", + "respectively", + "computationally", + "ring", + "largest", + "approach", + "proteins", + "acting", + "modular", + "architecture", + "may", + "found", + "carrying", + "evolution", + "four", + "duplication", + "computational", + "vital", + "surface", + "propeller", + "compensating", "fusion", - "form", + "homologue", + "different", + "processes", + "assembly", "platform", + "tako8", + "called", + "fold", + "also", + "charges", + "carry", + "complete", + "wide", + "solution", + "spontaneously", + "diversification", + "neighbouring", + "versatile", "history", - "blades", - "propeller", "per", - "respectively", - "ika4", - "families", - "four", - "tako8", - "artificial", - "may", + "evolutionary", + "form", + "employed", + "often", + "events", + "models", + "blades", + "many", + "one", + "structures", + "bionanotechnology", + "expressed", + "allowed", + "enzymatic", "closely", - "subfamily", + "inside", + "artificial", + "find", "activity", - "applications", + "abundant", "negative", - "surface", - "vital", - "subdomains", - "diversification", - "one", - "also", - "approach", - "study", - "wide", - "acting", - "stable", - "single", - "fold", - "enzymatic", - "carry", - "modular", - "different", - "subunit", - "found", - "two", - "events", - "spontaneously", - "protein", - "variety", - "computational", - "polypeptides", - "folding", + "rings", + "assemble", "create" ], "release_date":"2018-11-28", @@ -264403,19 +265289,19 @@ }, { "sim":437.0, - "partner":"6g6n" + "partner":"6g6m" }, { "sim":437.0, - "partner":"6y7p" + "partner":"6y7n" }, { "sim":437.0, - "partner":"6y7n" + "partner":"6g6n" }, { "sim":437.0, - "partner":"6g6m" + "partner":"6y7p" }, { "sim":333.0, @@ -264488,16 +265374,16 @@ "partner":"4cy5" }, { - "sim":156.0, - "partner":"6byn" + "sim":161.0, + "partner":"8rl2" }, { "sim":156.0, - "partner":"2g99" + "partner":"6byn" }, { "sim":156.0, - "partner":"5vfc" + "partner":"2g99" }, { "sim":156.0, @@ -264505,11 +265391,7 @@ }, { "sim":156.0, - "partner":"2h6k" - }, - { - "sim":156.0, - "partner":"5eap" + "partner":"5vfc" }, { "sim":156.0, @@ -264589,20 +265471,24 @@ }, { "sim":156.0, - "partner":"2h9n" + "partner":"2h6k" }, { "sim":156.0, - "partner":"6dai" + "partner":"5eap" }, { "sim":156.0, - "partner":"4gm8" + "partner":"6dai" }, { "sim":156.0, "partner":"6dak" }, + { + "sim":156.0, + "partner":"4gm8" + }, { "sim":156.0, "partner":"4gm3" @@ -264617,11 +265503,11 @@ }, { "sim":156.0, - "partner":"4gmb" + "partner":"6dar" }, { "sim":156.0, - "partner":"6dar" + "partner":"4gmb" }, { "sim":156.0, @@ -264639,6 +265525,10 @@ "sim":156.0, "partner":"2h9m" }, + { + "sim":156.0, + "partner":"2h9n" + }, { "sim":156.0, "partner":"5sxm" @@ -264713,11 +265603,11 @@ }, { "sim":156.0, - "partner":"2xl3" + "partner":"2xl2" }, { "sim":156.0, - "partner":"2xl2" + "partner":"2xl3" }, { "sim":156.0, @@ -264773,15 +265663,15 @@ }, { "sim":131.0, - "partner":"3jct" + "partner":"6ft6" }, { "sim":131.0, - "partner":"5jcs" + "partner":"3jct" }, { "sim":131.0, - "partner":"6ft6" + "partner":"5jcs" }, { "sim":131.0, @@ -264815,22 +265705,10 @@ "sim":125.0, "partner":"4aow" }, - { - "sim":124.0, - "partner":"6fec" - }, - { - "sim":124.0, - "partner":"6mtb" - }, { "sim":124.0, "partner":"3jaj" }, - { - "sim":124.0, - "partner":"8ukb" - }, { "sim":124.0, "partner":"6mtd" @@ -264845,12 +265723,16 @@ }, { "sim":124.0, - "partner":"3jah" + "partner":"8ukb" }, { "sim":124.0, "partner":"6mtc" }, + { + "sim":124.0, + "partner":"3jah" + }, { "sim":124.0, "partner":"6mte" @@ -264865,11 +265747,11 @@ }, { "sim":124.0, - "partner":"5lzv" + "partner":"6fec" }, { "sim":124.0, - "partner":"4kzx" + "partner":"6mtb" }, { "sim":124.0, @@ -264913,27 +265795,31 @@ }, { "sim":124.0, - "partner":"5lzu" + "partner":"6hcm" }, { "sim":124.0, - "partner":"6hcm" + "partner":"5lzu" }, { "sim":124.0, "partner":"5lks" }, + { + "sim":124.0, + "partner":"6g18" + }, { "sim":124.0, "partner":"5lzx" }, { "sim":124.0, - "partner":"8vft" + "partner":"6g51" }, { "sim":124.0, - "partner":"6g18" + "partner":"6hcq" }, { "sim":124.0, @@ -264945,27 +265831,27 @@ }, { "sim":124.0, - "partner":"6g51" + "partner":"8vft" }, { "sim":124.0, - "partner":"6hcq" + "partner":"5flx" }, { "sim":124.0, - "partner":"5flx" + "partner":"6d90" }, { "sim":124.0, - "partner":"5lzt" + "partner":"6hcj" }, { "sim":124.0, - "partner":"6d90" + "partner":"5lzt" }, { "sim":124.0, - "partner":"6hcj" + "partner":"6d9j" }, { "sim":124.0, @@ -264973,19 +265859,19 @@ }, { "sim":124.0, - "partner":"5lzw" + "partner":"6g5h" }, { "sim":124.0, - "partner":"5t2c" + "partner":"5lzw" }, { "sim":124.0, - "partner":"6d9j" + "partner":"5t2c" }, { "sim":124.0, - "partner":"6g5h" + "partner":"6g5i" }, { "sim":124.0, @@ -264993,15 +265879,15 @@ }, { "sim":124.0, - "partner":"6g5i" + "partner":"4d5l" }, { "sim":124.0, - "partner":"4d5l" + "partner":"5lzz" }, { "sim":124.0, - "partner":"5lzz" + "partner":"6g53" }, { "sim":124.0, @@ -265013,7 +265899,11 @@ }, { "sim":124.0, - "partner":"6g53" + "partner":"5lzv" + }, + { + "sim":124.0, + "partner":"4kzx" }, { "sim":122.0, @@ -265063,10 +265953,22 @@ "sim":117.0, "partner":"3ow8" }, + { + "sim":117.0, + "partner":"8zfz" + }, { "sim":117.0, "partner":"8vhf" }, + { + "sim":117.0, + "partner":"8wwi" + }, + { + "sim":117.0, + "partner":"8wwj" + }, { "sim":117.0, "partner":"8wwk" @@ -265089,11 +265991,7 @@ }, { "sim":117.0, - "partner":"8wwi" - }, - { - "sim":117.0, - "partner":"8wwj" + "partner":"8jsr" }, { "sim":117.0, @@ -265113,7 +266011,7 @@ }, { "sim":116.0, - "partner":"5ukk" + "partner":"8wgb" }, { "sim":116.0, @@ -265137,23 +266035,23 @@ }, { "sim":116.0, - "partner":"5he2" + "partner":"6g79" }, { "sim":116.0, - "partner":"6g79" + "partner":"5he2" }, { "sim":116.0, - "partner":"8wgb" + "partner":"5he3" }, { "sim":116.0, - "partner":"5he3" + "partner":"5ukk" }, { "sim":116.0, - "partner":"4kfm" + "partner":"8k4s" }, { "sim":116.0, @@ -265165,27 +266063,31 @@ }, { "sim":116.0, - "partner":"8k4s" + "partner":"8p15" }, { "sim":116.0, - "partner":"1gg2" + "partner":"8vve" }, { "sim":116.0, - "partner":"3pvu" + "partner":"8vvf" }, { "sim":116.0, - "partner":"4pnk" + "partner":"6c2y" }, { "sim":116.0, - "partner":"6c2y" + "partner":"8zjg" }, { "sim":116.0, - "partner":"8p12" + "partner":"3pvu" + }, + { + "sim":116.0, + "partner":"4pnk" }, { "sim":116.0, @@ -265201,7 +266103,11 @@ }, { "sim":116.0, - "partner":"1gp2" + "partner":"8vvg" + }, + { + "sim":116.0, + "partner":"1gg2" }, { "sim":116.0, @@ -265221,7 +266127,7 @@ }, { "sim":116.0, - "partner":"8p13" + "partner":"1gp2" }, { "sim":116.0, @@ -265239,6 +266145,14 @@ "sim":116.0, "partner":"3pvw" }, + { + "sim":116.0, + "partner":"8p12" + }, + { + "sim":116.0, + "partner":"8xqe" + }, { "sim":116.0, "partner":"3krw" @@ -265247,13 +266161,25 @@ "sim":116.0, "partner":"5wg5" }, + { + "sim":116.0, + "partner":"8z7j" + }, { "sim":116.0, "partner":"3krx" }, { "sim":116.0, - "partner":"8p15" + "partner":"8p13" + }, + { + "sim":116.0, + "partner":"8xqf" + }, + { + "sim":116.0, + "partner":"4kfm" }, { "sim":116.0, @@ -265277,7 +266203,7 @@ }, { "sim":116.0, - "partner":"6d9h" + "partner":"8xx3" }, { "sim":116.0, @@ -265287,6 +266213,18 @@ "sim":116.0, "partner":"6e3y" }, + { + "sim":116.0, + "partner":"8xx7" + }, + { + "sim":116.0, + "partner":"8xwv" + }, + { + "sim":116.0, + "partner":"8xxh" + }, { "sim":116.0, "partner":"6b3j" @@ -265295,6 +266233,26 @@ "sim":116.0, "partner":"8tyw" }, + { + "sim":116.0, + "partner":"8jzp" + }, + { + "sim":116.0, + "partner":"8xxx" + }, + { + "sim":116.0, + "partner":"8xxr" + }, + { + "sim":116.0, + "partner":"6d9h" + }, + { + "sim":116.0, + "partner":"8xx6" + }, { "sim":116.0, "partner":"5vai" @@ -265321,11 +266279,11 @@ }, { "sim":115.0, - "partner":"1got" + "partner":"2trc" }, { "sim":115.0, - "partner":"2trc" + "partner":"1got" }, { "sim":115.0, @@ -265349,15 +266307,15 @@ }, { "sim":113.0, - "partner":"5z57" + "partner":"5z56" }, { "sim":113.0, - "partner":"5z56" + "partner":"5xjc" }, { "sim":113.0, - "partner":"5xjc" + "partner":"6ff4" }, { "sim":113.0, @@ -265369,7 +266327,7 @@ }, { "sim":113.0, - "partner":"6ff4" + "partner":"5z57" }, { "sim":113.0, @@ -265491,33 +266449,17 @@ "sim":108.0, "partner":"4v7h" }, - { - "sim":107.0, - "partner":"8ut0" - }, { "sim":107.0, "partner":"8uti" }, { "sim":107.0, - "partner":"4v92" - }, - { - "sim":107.0, - "partner":"4u4q" - }, - { - "sim":107.0, - "partner":"5obm" - }, - { - "sim":107.0, - "partner":"4u4r" + "partner":"8ut0" }, { "sim":107.0, - "partner":"5tgm" + "partner":"4v92" }, { "sim":107.0, @@ -265535,6 +266477,10 @@ "sim":107.0, "partner":"4uer" }, + { + "sim":107.0, + "partner":"6gqv" + }, { "sim":107.0, "partner":"4u4u" @@ -265545,7 +266491,7 @@ }, { "sim":107.0, - "partner":"6gqv" + "partner":"5tgm" }, { "sim":107.0, @@ -265567,6 +266513,10 @@ "sim":107.0, "partner":"5ndv" }, + { + "sim":107.0, + "partner":"6gq1" + }, { "sim":107.0, "partner":"5ndw" @@ -265581,7 +266531,7 @@ }, { "sim":107.0, - "partner":"6gq1" + "partner":"6gqb" }, { "sim":107.0, @@ -265595,10 +266545,6 @@ "sim":107.0, "partner":"5dgv" }, - { - "sim":107.0, - "partner":"6gqb" - }, { "sim":107.0, "partner":"4u50" @@ -265665,15 +266611,15 @@ }, { "sim":107.0, - "partner":"3j6y" + "partner":"4u4q" }, { "sim":107.0, - "partner":"4v8y" + "partner":"5obm" }, { "sim":107.0, - "partner":"5juo" + "partner":"4u4r" }, { "sim":107.0, @@ -265689,7 +266635,7 @@ }, { "sim":107.0, - "partner":"8p4v" + "partner":"3j78" }, { "sim":107.0, @@ -265697,19 +266643,19 @@ }, { "sim":107.0, - "partner":"8t3a" + "partner":"5juu" }, { "sim":107.0, - "partner":"8t30" + "partner":"8t3a" }, { "sim":107.0, - "partner":"3j78" + "partner":"8t30" }, { "sim":107.0, - "partner":"5juu" + "partner":"3j6x" }, { "sim":107.0, @@ -265717,19 +266663,19 @@ }, { "sim":107.0, - "partner":"3j6x" + "partner":"4v88" }, { "sim":107.0, - "partner":"8t3e" + "partner":"8p4v" }, { "sim":107.0, - "partner":"4v88" + "partner":"4v7r" }, { "sim":107.0, - "partner":"4v7r" + "partner":"8t3e" }, { "sim":107.0, @@ -265745,11 +266691,11 @@ }, { "sim":107.0, - "partner":"8p9a" + "partner":"4v8z" }, { "sim":107.0, - "partner":"4v8z" + "partner":"3j77" }, { "sim":107.0, @@ -265757,11 +266703,11 @@ }, { "sim":107.0, - "partner":"3j77" + "partner":"5jut" }, { "sim":107.0, - "partner":"5jut" + "partner":"6fai" }, { "sim":107.0, @@ -265769,12 +266715,24 @@ }, { "sim":107.0, - "partner":"6fai" + "partner":"8p9a" + }, + { + "sim":107.0, + "partner":"3j6y" + }, + { + "sim":107.0, + "partner":"4v8y" }, { "sim":107.0, "partner":"8t3b" }, + { + "sim":107.0, + "partner":"5juo" + }, { "sim":107.0, "partner":"8t3d" @@ -265807,10 +266765,6 @@ "sim":106.0, "partner":"6hqa" }, - { - "sim":106.0, - "partner":"5nzv" - }, { "sim":106.0, "partner":"5nzt" @@ -265847,6 +266801,10 @@ "sim":106.0, "partner":"5a1w" }, + { + "sim":106.0, + "partner":"5nzv" + }, { "sim":106.0, "partner":"3sfz" @@ -266017,19 +266975,19 @@ }, { "sim":91.0, - "partner":"5khr" + "partner":"5khu" }, { "sim":91.0, - "partner":"6f0x" + "partner":"5g04" }, { "sim":91.0, - "partner":"5khu" + "partner":"6f0x" }, { "sim":91.0, - "partner":"5g04" + "partner":"5khr" }, { "sim":87.0, @@ -266045,23 +267003,23 @@ }, { "sim":85.0, - "partner":"3jam" + "partner":"3j80" }, { "sim":85.0, - "partner":"3jap" + "partner":"3j81" }, { "sim":85.0, - "partner":"3j80" + "partner":"8s8k" }, { "sim":85.0, - "partner":"3j81" + "partner":"3jam" }, { "sim":85.0, - "partner":"8s8k" + "partner":"3jap" }, { "sim":85.0, @@ -266117,11 +267075,11 @@ }, { "sim":80.0, - "partner":"4v5o" + "partner":"4bts" }, { "sim":80.0, - "partner":"4bts" + "partner":"4v5o" }, { "sim":79.0, @@ -266213,11 +267171,11 @@ }, { "sim":70.0, - "partner":"5vh9" + "partner":"5vlj" }, { "sim":70.0, - "partner":"5vlj" + "partner":"5vh9" }, { "sim":70.0, @@ -266253,11 +267211,11 @@ }, { "sim":66.0, - "partner":"1gxr" + "partner":"2ce8" }, { "sim":66.0, - "partner":"2ce8" + "partner":"1gxr" }, { "sim":66.0, @@ -266291,10 +267249,6 @@ "sim":66.0, "partner":"3c9c" }, - { - "sim":65.0, - "partner":"5flc" - }, { "sim":65.0, "partner":"4jsv" @@ -266337,12 +267291,16 @@ }, { "sim":65.0, - "partner":"5wbu" + "partner":"5flc" }, { "sim":65.0, "partner":"5wby" }, + { + "sim":65.0, + "partner":"5wbu" + }, { "sim":65.0, "partner":"1pgu" @@ -266353,19 +267311,19 @@ }, { "sim":64.0, - "partner":"2xu7" + "partner":"6g16" }, { "sim":64.0, - "partner":"6g16" + "partner":"8vml" }, { "sim":64.0, - "partner":"5fxy" + "partner":"6c24" }, { "sim":64.0, - "partner":"6c24" + "partner":"5fxy" }, { "sim":64.0, @@ -266375,10 +267333,18 @@ "sim":64.0, "partner":"4pby" }, + { + "sim":64.0, + "partner":"8vmi" + }, { "sim":64.0, "partner":"4pbz" }, + { + "sim":64.0, + "partner":"8vnv" + }, { "sim":64.0, "partner":"4pc0" @@ -266387,10 +267353,18 @@ "sim":64.0, "partner":"6c23" }, + { + "sim":64.0, + "partner":"8vnz" + }, { "sim":64.0, "partner":"3gfc" }, + { + "sim":64.0, + "partner":"2xu7" + }, { "sim":64.0, "partner":"6bw3" @@ -266421,27 +267395,27 @@ }, { "sim":64.0, - "partner":"5xxq" + "partner":"5y1u" }, { "sim":64.0, - "partner":"5y1u" + "partner":"5xxq" }, { "sim":61.0, - "partner":"2aq5" + "partner":"2b4e" }, { "sim":61.0, - "partner":"2b4e" + "partner":"2aq5" }, { "sim":60.0, - "partner":"1pev" + "partner":"1nr0" }, { "sim":60.0, - "partner":"1nr0" + "partner":"1pev" }, { "sim":58.0, @@ -266585,104 +267559,104 @@ ], "subtitle":"Crystal structure of the computationally designed ika4 protein", "tags":[ - "artificial protein", "de novo protein", - "wd40 proteins" + "wd40 proteins", + "artificial protein" ], "keywords":[ - "largest", - "evolution", - "many", - "architecture", - "ring", - "complexes", - "spaced", - "expressed", - "roles", - "abundant", - "carrying", - "homologue", - "complete", - "find", - "versatile", - "compensating", - "allowed", + "made", + "wd40", + "subfamily", "redesign", - "computationally", "owing", - "duplication", - "ika2", + "spaced", + "complexes", + "single", + "ika4", + "families", + "roles", + "subunit", + "folding", + "symmetrical", + "protein", + "study", + "ika8", + "cellular", + "polypeptides", "intrinsic", + "two", + "variety", + "applications", "adapt", - "called", - "proteins", - "employed", - "models", - "neighbouring", - "ika8", + "stable", "involved", - "rings", - "bionanotechnology", - "processes", - "inside", - "evolutionary", - "often", - "made", - "wd40", - "assemble", - "charges", - "symmetrical", - "structures", + "subdomains", "perfectly", - "solution", - "assembly", - "cellular", + "ika2", + "respectively", + "computationally", + "ring", + "largest", + "approach", + "proteins", + "acting", + "modular", + "architecture", + "may", + "found", + "carrying", + "evolution", + "four", + "duplication", + "computational", + "vital", + "surface", + "propeller", + "compensating", "fusion", - "form", + "homologue", + "different", + "processes", + "assembly", "platform", + "tako8", + "called", + "fold", + "also", + "charges", + "carry", + "complete", + "wide", + "solution", + "spontaneously", + "diversification", + "neighbouring", + "versatile", "history", - "blades", - "propeller", "per", - "respectively", - "ika4", - "families", - "four", - "tako8", - "artificial", - "may", + "evolutionary", + "form", + "employed", + "often", + "events", + "models", + "blades", + "many", + "one", + "structures", + "bionanotechnology", + "expressed", + "allowed", + "enzymatic", "closely", - "subfamily", + "inside", + "artificial", + "find", "activity", - "applications", + "abundant", "negative", - "surface", - "vital", - "subdomains", - "diversification", - "one", - "also", - "approach", - "study", - "wide", - "acting", - "stable", - "single", - "fold", - "enzymatic", - "carry", - "modular", - "different", - "subunit", - "found", - "two", - "events", - "spontaneously", - "protein", - "variety", - "computational", - "polypeptides", - "folding", + "rings", + "assemble", "create" ], "release_date":"2018-11-28", @@ -266728,19 +267702,19 @@ }, { "sim":226.0, - "partner":"6g6n" + "partner":"6g6m" }, { "sim":226.0, - "partner":"6y7p" + "partner":"6y7n" }, { "sim":226.0, - "partner":"6y7n" + "partner":"6g6n" }, { "sim":226.0, - "partner":"6g6m" + "partner":"6y7p" }, { "sim":96.0, @@ -266812,21 +267786,13 @@ "sim":100.0, "partner":"2g99" }, - { - "sim":100.0, - "partner":"5vfc" - }, { "sim":100.0, "partner":"2g9a" }, { "sim":100.0, - "partner":"2h6k" - }, - { - "sim":100.0, - "partner":"5eap" + "partner":"5vfc" }, { "sim":100.0, @@ -266906,20 +267872,24 @@ }, { "sim":100.0, - "partner":"2h9n" + "partner":"2h6k" }, { "sim":100.0, - "partner":"6dai" + "partner":"5eap" }, { "sim":100.0, - "partner":"4gm8" + "partner":"6dai" }, { "sim":100.0, "partner":"6dak" }, + { + "sim":100.0, + "partner":"4gm8" + }, { "sim":100.0, "partner":"4gm3" @@ -266934,11 +267904,11 @@ }, { "sim":100.0, - "partner":"4gmb" + "partner":"6dar" }, { "sim":100.0, - "partner":"6dar" + "partner":"4gmb" }, { "sim":100.0, @@ -266956,6 +267926,10 @@ "sim":100.0, "partner":"2h9m" }, + { + "sim":100.0, + "partner":"2h9n" + }, { "sim":100.0, "partner":"5sxm" @@ -267034,11 +268008,11 @@ }, { "sim":100.0, - "partner":"2xl3" + "partner":"2xl2" }, { "sim":100.0, - "partner":"2xl2" + "partner":"2xl3" }, { "sim":100.0, @@ -267084,6 +268058,10 @@ "sim":93.0, "partner":"4v8m" }, + { + "sim":93.0, + "partner":"8rl2" + }, { "sim":93.0, "partner":"6mzm" @@ -267136,22 +268114,10 @@ "sim":88.0, "partner":"4v6w" }, - { - "sim":87.0, - "partner":"6fec" - }, - { - "sim":87.0, - "partner":"6mtb" - }, { "sim":87.0, "partner":"3jaj" }, - { - "sim":87.0, - "partner":"8ukb" - }, { "sim":87.0, "partner":"6mtd" @@ -267166,12 +268132,16 @@ }, { "sim":87.0, - "partner":"3jah" + "partner":"8ukb" }, { "sim":87.0, "partner":"6mtc" }, + { + "sim":87.0, + "partner":"3jah" + }, { "sim":87.0, "partner":"6mte" @@ -267186,19 +268156,19 @@ }, { "sim":87.0, - "partner":"5oa3" + "partner":"6fec" }, { "sim":87.0, - "partner":"5a2q" + "partner":"6mtb" }, { "sim":87.0, - "partner":"5lzv" + "partner":"5oa3" }, { "sim":87.0, - "partner":"4kzx" + "partner":"5a2q" }, { "sim":87.0, @@ -267242,27 +268212,31 @@ }, { "sim":87.0, - "partner":"5lzu" + "partner":"6hcm" }, { "sim":87.0, - "partner":"6hcm" + "partner":"5lzu" }, { "sim":87.0, "partner":"5lks" }, + { + "sim":87.0, + "partner":"6g18" + }, { "sim":87.0, "partner":"5lzx" }, { "sim":87.0, - "partner":"8vft" + "partner":"6g51" }, { "sim":87.0, - "partner":"6g18" + "partner":"6hcq" }, { "sim":87.0, @@ -267274,27 +268248,27 @@ }, { "sim":87.0, - "partner":"6g51" + "partner":"8vft" }, { "sim":87.0, - "partner":"6hcq" + "partner":"5flx" }, { "sim":87.0, - "partner":"5flx" + "partner":"6d90" }, { "sim":87.0, - "partner":"5lzt" + "partner":"6hcj" }, { "sim":87.0, - "partner":"6d90" + "partner":"5lzt" }, { "sim":87.0, - "partner":"6hcj" + "partner":"6d9j" }, { "sim":87.0, @@ -267302,19 +268276,19 @@ }, { "sim":87.0, - "partner":"5lzw" + "partner":"6g5h" }, { "sim":87.0, - "partner":"5t2c" + "partner":"5lzw" }, { "sim":87.0, - "partner":"6d9j" + "partner":"5t2c" }, { "sim":87.0, - "partner":"6g5h" + "partner":"6g5i" }, { "sim":87.0, @@ -267322,15 +268296,15 @@ }, { "sim":87.0, - "partner":"6g5i" + "partner":"4d5l" }, { "sim":87.0, - "partner":"4d5l" + "partner":"5lzz" }, { "sim":87.0, - "partner":"5lzz" + "partner":"6g53" }, { "sim":87.0, @@ -267342,7 +268316,11 @@ }, { "sim":87.0, - "partner":"6g53" + "partner":"5lzv" + }, + { + "sim":87.0, + "partner":"4kzx" }, { "sim":87.0, @@ -267398,24 +268376,20 @@ }, { "sim":85.0, - "partner":"3jct" + "partner":"6ft6" }, { "sim":85.0, - "partner":"5jcs" + "partner":"3jct" }, { "sim":85.0, - "partner":"6ft6" + "partner":"5jcs" }, { "sim":85.0, "partner":"4wju" }, - { - "sim":85.0, - "partner":"5nzv" - }, { "sim":85.0, "partner":"5nzt" @@ -267452,6 +268426,10 @@ "sim":85.0, "partner":"5a1w" }, + { + "sim":85.0, + "partner":"5nzv" + }, { "sim":84.0, "partner":"4wjv" @@ -267522,11 +268500,11 @@ }, { "sim":81.0, - "partner":"8ut0" + "partner":"8uti" }, { "sim":81.0, - "partner":"8uti" + "partner":"8ut0" }, { "sim":81.0, @@ -267544,22 +268522,6 @@ "sim":81.0, "partner":"4v92" }, - { - "sim":81.0, - "partner":"4u4q" - }, - { - "sim":81.0, - "partner":"5obm" - }, - { - "sim":81.0, - "partner":"4u4r" - }, - { - "sim":81.0, - "partner":"5tgm" - }, { "sim":81.0, "partner":"4u6f" @@ -267576,6 +268538,10 @@ "sim":81.0, "partner":"4uer" }, + { + "sim":81.0, + "partner":"6gqv" + }, { "sim":81.0, "partner":"4u4u" @@ -267586,7 +268552,7 @@ }, { "sim":81.0, - "partner":"6gqv" + "partner":"5tgm" }, { "sim":81.0, @@ -267608,6 +268574,10 @@ "sim":81.0, "partner":"5ndv" }, + { + "sim":81.0, + "partner":"6gq1" + }, { "sim":81.0, "partner":"5ndw" @@ -267622,7 +268592,7 @@ }, { "sim":81.0, - "partner":"6gq1" + "partner":"6gqb" }, { "sim":81.0, @@ -267636,10 +268606,6 @@ "sim":81.0, "partner":"5dgv" }, - { - "sim":81.0, - "partner":"6gqb" - }, { "sim":81.0, "partner":"4u50" @@ -267706,15 +268672,15 @@ }, { "sim":81.0, - "partner":"3j6y" + "partner":"4u4q" }, { "sim":81.0, - "partner":"4v8y" + "partner":"5obm" }, { "sim":81.0, - "partner":"5juo" + "partner":"4u4r" }, { "sim":81.0, @@ -267730,7 +268696,7 @@ }, { "sim":81.0, - "partner":"8p4v" + "partner":"3j78" }, { "sim":81.0, @@ -267738,47 +268704,47 @@ }, { "sim":81.0, - "partner":"8t3a" + "partner":"3rfg" }, { "sim":81.0, - "partner":"8t30" + "partner":"5juu" }, { "sim":81.0, - "partner":"3j78" + "partner":"8t3a" }, { "sim":81.0, - "partner":"3rfg" + "partner":"8t30" }, { "sim":81.0, - "partner":"5juu" + "partner":"3j6x" }, { "sim":81.0, - "partner":"8t3c" + "partner":"3rfh" }, { "sim":81.0, - "partner":"3j6x" + "partner":"8t3c" }, { "sim":81.0, - "partner":"3rfh" + "partner":"4v88" }, { "sim":81.0, - "partner":"8t3e" + "partner":"8p4v" }, { "sim":81.0, - "partner":"4v88" + "partner":"4v7r" }, { "sim":81.0, - "partner":"4v7r" + "partner":"8t3e" }, { "sim":81.0, @@ -267794,11 +268760,11 @@ }, { "sim":81.0, - "partner":"8p9a" + "partner":"4v8z" }, { "sim":81.0, - "partner":"4v8z" + "partner":"3j77" }, { "sim":81.0, @@ -267806,11 +268772,11 @@ }, { "sim":81.0, - "partner":"3j77" + "partner":"5jut" }, { "sim":81.0, - "partner":"5jut" + "partner":"6fai" }, { "sim":81.0, @@ -267818,12 +268784,24 @@ }, { "sim":81.0, - "partner":"6fai" + "partner":"8p9a" + }, + { + "sim":81.0, + "partner":"3j6y" + }, + { + "sim":81.0, + "partner":"4v8y" }, { "sim":81.0, "partner":"8t3b" }, + { + "sim":81.0, + "partner":"5juo" + }, { "sim":81.0, "partner":"8t3d" @@ -267862,7 +268840,7 @@ }, { "sim":79.0, - "partner":"5ukk" + "partner":"8wgb" }, { "sim":79.0, @@ -267884,17 +268862,13 @@ "sim":79.0, "partner":"5he1" }, - { - "sim":79.0, - "partner":"5he2" - }, { "sim":79.0, "partner":"6g79" }, { "sim":79.0, - "partner":"8wgb" + "partner":"5he2" }, { "sim":79.0, @@ -267902,11 +268876,11 @@ }, { "sim":79.0, - "partner":"4kfm" + "partner":"5ukk" }, { "sim":79.0, - "partner":"1got" + "partner":"8k4s" }, { "sim":79.0, @@ -267918,23 +268892,23 @@ }, { "sim":79.0, - "partner":"3v5w" + "partner":"1got" }, { "sim":79.0, - "partner":"8k4s" + "partner":"3v5w" }, { "sim":79.0, - "partner":"1gg2" + "partner":"8p15" }, { "sim":79.0, - "partner":"3pvu" + "partner":"8vve" }, { "sim":79.0, - "partner":"4pnk" + "partner":"8vvf" }, { "sim":79.0, @@ -267942,7 +268916,15 @@ }, { "sim":79.0, - "partner":"8p12" + "partner":"8zjg" + }, + { + "sim":79.0, + "partner":"3pvu" + }, + { + "sim":79.0, + "partner":"4pnk" }, { "sim":79.0, @@ -267954,15 +268936,15 @@ }, { "sim":79.0, - "partner":"1b9x" + "partner":"2bcj" }, { "sim":79.0, - "partner":"2bcj" + "partner":"8vvg" }, { "sim":79.0, - "partner":"1gp2" + "partner":"1gg2" }, { "sim":79.0, @@ -267970,7 +268952,7 @@ }, { "sim":79.0, - "partner":"1b9y" + "partner":"1b9x" }, { "sim":79.0, @@ -267986,7 +268968,7 @@ }, { "sim":79.0, - "partner":"8p13" + "partner":"1gp2" }, { "sim":79.0, @@ -267998,7 +268980,7 @@ }, { "sim":79.0, - "partner":"1a0r" + "partner":"1b9y" }, { "sim":79.0, @@ -268008,6 +268990,14 @@ "sim":79.0, "partner":"3pvw" }, + { + "sim":79.0, + "partner":"8p12" + }, + { + "sim":79.0, + "partner":"8xqe" + }, { "sim":79.0, "partner":"3krw" @@ -268016,13 +269006,29 @@ "sim":79.0, "partner":"5wg5" }, + { + "sim":79.0, + "partner":"1a0r" + }, + { + "sim":79.0, + "partner":"8z7j" + }, { "sim":79.0, "partner":"3krx" }, { "sim":79.0, - "partner":"8p15" + "partner":"8p13" + }, + { + "sim":79.0, + "partner":"8xqf" + }, + { + "sim":79.0, + "partner":"4kfm" }, { "sim":79.0, @@ -268046,7 +269052,7 @@ }, { "sim":79.0, - "partner":"6d9h" + "partner":"8xx3" }, { "sim":79.0, @@ -268056,17 +269062,49 @@ "sim":79.0, "partner":"6e3y" }, + { + "sim":79.0, + "partner":"8xx7" + }, + { + "sim":79.0, + "partner":"8xwv" + }, + { + "sim":79.0, + "partner":"8xxh" + }, { "sim":79.0, "partner":"6b3j" }, + { + "sim":79.0, + "partner":"8tyw" + }, + { + "sim":79.0, + "partner":"8jzp" + }, { "sim":79.0, "partner":"5afu" }, { "sim":79.0, - "partner":"8tyw" + "partner":"8xxx" + }, + { + "sim":79.0, + "partner":"8xxr" + }, + { + "sim":79.0, + "partner":"6d9h" + }, + { + "sim":79.0, + "partner":"8xx6" }, { "sim":79.0, @@ -268088,10 +269126,22 @@ "sim":79.0, "partner":"8rql" }, + { + "sim":79.0, + "partner":"8zfz" + }, { "sim":79.0, "partner":"8vhf" }, + { + "sim":79.0, + "partner":"8wwi" + }, + { + "sim":79.0, + "partner":"8wwj" + }, { "sim":79.0, "partner":"8wwk" @@ -268114,11 +269164,7 @@ }, { "sim":79.0, - "partner":"8wwi" - }, - { - "sim":79.0, - "partner":"8wwj" + "partner":"8jsr" }, { "sim":78.0, @@ -268358,23 +269404,23 @@ }, { "sim":63.0, - "partner":"3jam" + "partner":"3j80" }, { "sim":63.0, - "partner":"3jap" + "partner":"3j81" }, { "sim":63.0, - "partner":"3j80" + "partner":"8s8k" }, { "sim":63.0, - "partner":"3j81" + "partner":"3jam" }, { "sim":63.0, - "partner":"8s8k" + "partner":"3jap" }, { "sim":63.0, @@ -268386,11 +269432,11 @@ }, { "sim":63.0, - "partner":"4v5o" + "partner":"4bts" }, { "sim":63.0, - "partner":"4bts" + "partner":"4v5o" }, { "sim":63.0, @@ -268422,11 +269468,11 @@ }, { "sim":59.0, - "partner":"5vh9" + "partner":"5vlj" }, { "sim":59.0, - "partner":"5vlj" + "partner":"5vh9" }, { "sim":59.0, @@ -268438,11 +269484,11 @@ }, { "sim":58.0, - "partner":"2aq5" + "partner":"2b4e" }, { "sim":58.0, - "partner":"2b4e" + "partner":"2aq5" }, { "sim":57.0, @@ -268518,19 +269564,19 @@ }, { "sim":56.0, - "partner":"2xu7" + "partner":"6g16" }, { "sim":56.0, - "partner":"6g16" + "partner":"8vml" }, { "sim":56.0, - "partner":"5fxy" + "partner":"6c24" }, { "sim":56.0, - "partner":"6c24" + "partner":"5fxy" }, { "sim":56.0, @@ -268540,10 +269586,18 @@ "sim":56.0, "partner":"4pby" }, + { + "sim":56.0, + "partner":"8vmi" + }, { "sim":56.0, "partner":"4pbz" }, + { + "sim":56.0, + "partner":"8vnv" + }, { "sim":56.0, "partner":"4pc0" @@ -268552,10 +269606,18 @@ "sim":56.0, "partner":"6c23" }, + { + "sim":56.0, + "partner":"8vnz" + }, { "sim":56.0, "partner":"3gfc" }, + { + "sim":56.0, + "partner":"2xu7" + }, { "sim":56.0, "partner":"6bw3" @@ -268598,11 +269660,11 @@ }, { "sim":56.0, - "partner":"5xxq" + "partner":"5y1u" }, { "sim":56.0, - "partner":"5y1u" + "partner":"5xxq" }, { "sim":55.0, @@ -268630,19 +269692,19 @@ }, { "sim":55.0, - "partner":"5khr" + "partner":"5khu" }, { "sim":55.0, - "partner":"6f0x" + "partner":"5g04" }, { "sim":55.0, - "partner":"5khu" + "partner":"6f0x" }, { "sim":55.0, - "partner":"5g04" + "partner":"5khr" }, { "sim":54.0, @@ -268674,11 +269736,11 @@ }, { "sim":52.0, - "partner":"1gxr" + "partner":"2ce8" }, { "sim":52.0, - "partner":"2ce8" + "partner":"1gxr" }, { "sim":52.0, @@ -268774,76 +269836,76 @@ ], "subtitle":"A computationally designed drp lyase domain reconstructed from two heterologous fragments", "tags":[ - "unknown function", + "protein design", "drp lyase domain", - "protein design" + "unknown function" ], "keywords":[ - "heterologous", - "accuracy", - "depart", - "domain", - "propensity", - "results", "construction", - "proteins", - "approach", - "report", - "strategy", - "globular", - "combined", + "geometries", + "achieve", "asymmetric", - "\u00e5", - "conserved", + "effective", "rmsd", - "experimental", - "fold", - "efficient", - "sufficient", - "information", - "properties", - "fragments", - "controlled", - "geometries", - "effectively", - "proven", - "drp", - "supersecondary", - "successful", - "enthalpy", - "realm", - "new", - "lyase", - "far", - "blocks", - "amplification", - "constructing", "design", - "show", - "residual", + "controlled", "sampling", + "efficient", + "conserved", "sequences", - "effective", + "atomic", + "repeat", + "constructing", + "show", "structures", + "fragments", + "supersecondary", + "drp", + "experimental", + "information", + "amplification", + "domain", + "\u00e5", + "properties", + "structure", + "fold", + "within", + "report", + "results", + "new", + "folding", + "strategy", + "successful", + "primarily", + "nmr", + "biophysical", + "heterologous", "yield", - "exploit", - "agrees", + "globular", + "approach", + "propensity", + "blocks", + "proteins", + "combined", + "internal", + "accuracy", "backbone", - "nmr", - "atomic", - "structure", - "repeat", + "agrees", + "far", + "building", + "proven", + "depart", + "sufficient", + "exploit", + "residual", + "effectively", + "enthalpy", + "realm", "exploited", "harnessing", - "within", "computational", - "building", - "folding", - "achieve", - "novel", - "internal", - "biophysical", - "primarily" + "lyase", + "novel" ], "release_date":"2018-12-12", "publication":"\"Asymmetric protein design from conserved supersecondary structures\", J. Struct. Biol., 204, 380-387", @@ -268889,14 +269951,6 @@ "sim":126.0, "partner":"3v7l" }, - { - "sim":123.0, - "partner":"4o5c" - }, - { - "sim":123.0, - "partner":"4nlk" - }, { "sim":123.0, "partner":"4o5e" @@ -268955,103 +270009,11 @@ }, { "sim":123.0, - "partner":"1zqr" - }, - { - "sim":123.0, - "partner":"3rjg" - }, - { - "sim":123.0, - "partner":"4f5q" - }, - { - "sim":123.0, - "partner":"4ub4" - }, - { - "sim":123.0, - "partner":"5v1r" - }, - { - "sim":123.0, - "partner":"6cr7" - }, - { - "sim":123.0, - "partner":"8ici" - }, - { - "sim":123.0, - "partner":"2pxi" - }, - { - "sim":123.0, - "partner":"3c2l" - }, - { - "sim":123.0, - "partner":"4yn4" - }, - { - "sim":123.0, - "partner":"5dbb" - }, - { - "sim":123.0, - "partner":"7icl" - }, - { - "sim":123.0, - "partner":"8ict" - }, - { - "sim":123.0, - "partner":"9icm" - }, - { - "sim":123.0, - "partner":"1zqh" - }, - { - "sim":123.0, - "partner":"3isd" - }, - { - "sim":123.0, - "partner":"3jpn" - }, - { - "sim":123.0, - "partner":"3v72" - }, - { - "sim":123.0, - "partner":"4doa" - }, - { - "sim":123.0, - "partner":"4klh" - }, - { - "sim":123.0, - "partner":"4rt3" - }, - { - "sim":123.0, - "partner":"5j2f" - }, - { - "sim":123.0, - "partner":"5wo0" - }, - { - "sim":123.0, - "partner":"9icb" + "partner":"4o5c" }, { "sim":123.0, - "partner":"9icx" + "partner":"4nlk" }, { "sim":123.0, @@ -269079,7 +270041,7 @@ }, { "sim":123.0, - "partner":"8icj" + "partner":"7icm" }, { "sim":123.0, @@ -269115,19 +270077,11 @@ }, { "sim":123.0, - "partner":"6cr8" - }, - { - "sim":123.0, - "partner":"7icm" - }, - { - "sim":123.0, - "partner":"8icu" + "partner":"8icl" }, { "sim":123.0, - "partner":"9icn" + "partner":"9ico" }, { "sim":123.0, @@ -269155,11 +270109,11 @@ }, { "sim":123.0, - "partner":"9icc" + "partner":"8ica" }, { "sim":123.0, - "partner":"9icy" + "partner":"8icw" }, { "sim":123.0, @@ -269195,7 +270149,15 @@ }, { "sim":123.0, - "partner":"8ick" + "partner":"6cr9" + }, + { + "sim":123.0, + "partner":"7icn" + }, + { + "sim":123.0, + "partner":"9ice" }, { "sim":123.0, @@ -269211,15 +270173,15 @@ }, { "sim":123.0, - "partner":"7icn" + "partner":"6crb" }, { "sim":123.0, - "partner":"8icv" + "partner":"8icm" }, { "sim":123.0, - "partner":"9ico" + "partner":"9icp" }, { "sim":123.0, @@ -269251,23 +270213,23 @@ }, { "sim":123.0, - "partner":"6cr9" + "partner":"8icb" }, { "sim":123.0, - "partner":"5u8h" + "partner":"8icx" }, { "sim":123.0, - "partner":"6crb" + "partner":"5u8h" }, { "sim":123.0, - "partner":"8icl" + "partner":"7ico" }, { "sim":123.0, - "partner":"9ice" + "partner":"9icf" }, { "sim":123.0, @@ -269303,27 +270265,35 @@ }, { "sim":123.0, - "partner":"7ico" + "partner":"8icn" }, { "sim":123.0, - "partner":"8ica" + "partner":"9icq" }, { "sim":123.0, - "partner":"8icw" + "partner":"1zqk" }, { "sim":123.0, - "partner":"9icp" + "partner":"5j0r" }, { "sim":123.0, - "partner":"1zqk" + "partner":"6crc" }, { "sim":123.0, - "partner":"5j0r" + "partner":"7ice" + }, + { + "sim":123.0, + "partner":"8icc" + }, + { + "sim":123.0, + "partner":"8icy" }, { "sim":123.0, @@ -269343,15 +270313,11 @@ }, { "sim":123.0, - "partner":"7ice" - }, - { - "sim":123.0, - "partner":"8icm" + "partner":"7icp" }, { "sim":123.0, - "partner":"9icf" + "partner":"9icg" }, { "sim":123.0, @@ -269379,39 +270345,35 @@ }, { "sim":123.0, - "partner":"6crc" - }, - { - "sim":123.0, - "partner":"7icp" + "partner":"8ico" }, { "sim":123.0, - "partner":"8icb" + "partner":"9icr" }, { "sim":123.0, - "partner":"8icx" + "partner":"1zql" }, { "sim":123.0, - "partner":"9icq" + "partner":"3jpq" }, { "sim":123.0, - "partner":"1zql" + "partner":"5j2a" }, { "sim":123.0, - "partner":"3jpq" + "partner":"5j2i" }, { "sim":123.0, - "partner":"5j2a" + "partner":"7icf" }, { "sim":123.0, - "partner":"5j2i" + "partner":"8icz" }, { "sim":123.0, @@ -269435,15 +270397,15 @@ }, { "sim":123.0, - "partner":"7icf" + "partner":"7icq" }, { "sim":123.0, - "partner":"8icn" + "partner":"8ice" }, { "sim":123.0, - "partner":"9icg" + "partner":"9ich" }, { "sim":123.0, @@ -269459,23 +270421,11 @@ }, { "sim":123.0, - "partner":"7icq" - }, - { - "sim":123.0, - "partner":"8icc" - }, - { - "sim":123.0, - "partner":"8icy" - }, - { - "sim":123.0, - "partner":"9icr" + "partner":"8icp" }, { "sim":123.0, - "partner":"1huz" + "partner":"9ics" }, { "sim":123.0, @@ -269517,6 +270467,14 @@ "sim":123.0, "partner":"5eoz" }, + { + "sim":123.0, + "partner":"6bte" + }, + { + "sim":123.0, + "partner":"7icg" + }, { "sim":123.0, "partner":"1tv9" @@ -269547,15 +270505,19 @@ }, { "sim":123.0, - "partner":"7icg" + "partner":"6cr4" }, { "sim":123.0, - "partner":"8ico" + "partner":"7icr" }, { "sim":123.0, - "partner":"9ich" + "partner":"8icf" + }, + { + "sim":123.0, + "partner":"9ici" }, { "sim":123.0, @@ -269587,19 +270549,15 @@ }, { "sim":123.0, - "partner":"6bte" - }, - { - "sim":123.0, - "partner":"7icr" + "partner":"8icq" }, { "sim":123.0, - "partner":"8icz" + "partner":"9ict" }, { "sim":123.0, - "partner":"9ics" + "partner":"1huz" }, { "sim":123.0, @@ -269627,15 +270585,7 @@ }, { "sim":123.0, - "partner":"6cr4" - }, - { - "sim":123.0, - "partner":"8ice" - }, - { - "sim":123.0, - "partner":"1bpx" + "partner":"7ich" }, { "sim":123.0, @@ -269659,15 +270609,19 @@ }, { "sim":123.0, - "partner":"7ich" + "partner":"6btf" }, { "sim":123.0, - "partner":"8icp" + "partner":"7ics" }, { "sim":123.0, - "partner":"9ici" + "partner":"8icg" + }, + { + "sim":123.0, + "partner":"9icj" }, { "sim":123.0, @@ -269707,11 +270661,15 @@ }, { "sim":123.0, - "partner":"7ics" + "partner":"6cr5" }, { "sim":123.0, - "partner":"9ict" + "partner":"8icr" + }, + { + "sim":123.0, + "partner":"9icu" }, { "sim":123.0, @@ -269731,11 +270689,11 @@ }, { "sim":123.0, - "partner":"6btf" + "partner":"7ici" }, { "sim":123.0, - "partner":"8icf" + "partner":"1bpx" }, { "sim":123.0, @@ -269759,23 +270717,15 @@ }, { "sim":123.0, - "partner":"6cr5" - }, - { - "sim":123.0, - "partner":"7ici" - }, - { - "sim":123.0, - "partner":"8icq" + "partner":"7ict" }, { "sim":123.0, - "partner":"9icj" + "partner":"8ich" }, { "sim":123.0, - "partner":"1bpy" + "partner":"9ick" }, { "sim":123.0, @@ -269807,11 +270757,11 @@ }, { "sim":123.0, - "partner":"7ict" + "partner":"8ics" }, { "sim":123.0, - "partner":"9icu" + "partner":"9icv" }, { "sim":123.0, @@ -269843,15 +270793,11 @@ }, { "sim":123.0, - "partner":"8icg" - }, - { - "sim":123.0, - "partner":"1bpd" + "partner":"6cr6" }, { "sim":123.0, - "partner":"1huo" + "partner":"7icj" }, { "sim":123.0, @@ -269867,15 +270813,19 @@ }, { "sim":123.0, - "partner":"7icj" + "partner":"7icu" }, { "sim":123.0, - "partner":"8icr" + "partner":"8ici" }, { "sim":123.0, - "partner":"9ick" + "partner":"9icl" + }, + { + "sim":123.0, + "partner":"1bpy" }, { "sim":123.0, @@ -269903,19 +270853,15 @@ }, { "sim":123.0, - "partner":"6cr6" - }, - { - "sim":123.0, - "partner":"7icu" + "partner":"8ict" }, { "sim":123.0, - "partner":"9icv" + "partner":"9ica" }, { "sim":123.0, - "partner":"1bpz" + "partner":"9icw" }, { "sim":123.0, @@ -269947,7 +270893,19 @@ }, { "sim":123.0, - "partner":"8ich" + "partner":"6g2q" + }, + { + "sim":123.0, + "partner":"7ick" + }, + { + "sim":123.0, + "partner":"1bpd" + }, + { + "sim":123.0, + "partner":"1huo" }, { "sim":123.0, @@ -269979,15 +270937,19 @@ }, { "sim":123.0, - "partner":"7ick" + "partner":"6cr7" }, { "sim":123.0, - "partner":"8ics" + "partner":"7icv" }, { "sim":123.0, - "partner":"9icl" + "partner":"8icj" + }, + { + "sim":123.0, + "partner":"9icm" }, { "sim":123.0, @@ -270011,27 +270973,119 @@ }, { "sim":123.0, - "partner":"6g2q" + "partner":"8icu" }, { "sim":123.0, - "partner":"7icv" + "partner":"9icb" }, { "sim":123.0, - "partner":"9ica" + "partner":"9icx" }, { "sim":123.0, - "partner":"9icw" + "partner":"1bpz" }, { "sim":123.0, - "partner":"5vrz" + "partner":"1zqr" }, { "sim":123.0, - "partner":"5vs0" + "partner":"3rjg" + }, + { + "sim":123.0, + "partner":"4f5q" + }, + { + "sim":123.0, + "partner":"4ub4" + }, + { + "sim":123.0, + "partner":"5v1r" + }, + { + "sim":123.0, + "partner":"7icl" + }, + { + "sim":123.0, + "partner":"2pxi" + }, + { + "sim":123.0, + "partner":"3c2l" + }, + { + "sim":123.0, + "partner":"4yn4" + }, + { + "sim":123.0, + "partner":"5dbb" + }, + { + "sim":123.0, + "partner":"8ick" + }, + { + "sim":123.0, + "partner":"9icn" + }, + { + "sim":123.0, + "partner":"1zqh" + }, + { + "sim":123.0, + "partner":"3isd" + }, + { + "sim":123.0, + "partner":"3jpn" + }, + { + "sim":123.0, + "partner":"3v72" + }, + { + "sim":123.0, + "partner":"4doa" + }, + { + "sim":123.0, + "partner":"4klh" + }, + { + "sim":123.0, + "partner":"4rt3" + }, + { + "sim":123.0, + "partner":"5j2f" + }, + { + "sim":123.0, + "partner":"5wo0" + }, + { + "sim":123.0, + "partner":"6cr8" + }, + { + "sim":123.0, + "partner":"8icv" + }, + { + "sim":123.0, + "partner":"9icc" + }, + { + "sim":123.0, + "partner":"9icy" }, { "sim":123.0, @@ -270063,11 +271117,11 @@ }, { "sim":123.0, - "partner":"4rpz" + "partner":"5vrz" }, { "sim":123.0, - "partner":"4rq7" + "partner":"5vs0" }, { "sim":123.0, @@ -270142,24 +271196,20 @@ "partner":"4rq6" }, { - "sim":122.0, - "partner":"1bpe" - }, - { - "sim":121.0, - "partner":"5hhh" + "sim":123.0, + "partner":"4rpz" }, { - "sim":121.0, - "partner":"6ctw" + "sim":123.0, + "partner":"4rq7" }, { - "sim":121.0, - "partner":"6cto" + "sim":122.0, + "partner":"1bpe" }, { "sim":121.0, - "partner":"6ctx" + "partner":"5hhh" }, { "sim":121.0, @@ -270213,6 +271263,18 @@ "sim":121.0, "partner":"6ctn" }, + { + "sim":121.0, + "partner":"6ctw" + }, + { + "sim":121.0, + "partner":"6cto" + }, + { + "sim":121.0, + "partner":"6ctx" + }, { "sim":120.0, "partner":"3ogu" @@ -270297,10 +271359,6 @@ "sim":98.0, "partner":"1bnp" }, - { - "sim":70.0, - "partner":"2w2n" - }, { "sim":70.0, "partner":"2w2o" @@ -270317,6 +271375,10 @@ "sim":70.0, "partner":"2w2m" }, + { + "sim":70.0, + "partner":"2w2n" + }, { "sim":70.0, "partner":"2cgq" @@ -270347,35 +271409,35 @@ }, { "sim":67.0, - "partner":"6eq2" + "partner":"6eq4" }, { "sim":67.0, - "partner":"6eq3" + "partner":"6eq5" }, { "sim":67.0, - "partner":"6eq4" + "partner":"6eq6" }, { "sim":67.0, - "partner":"6eq5" + "partner":"6eq7" }, { "sim":67.0, - "partner":"6eq6" + "partner":"6eq2" }, { "sim":67.0, - "partner":"6eq7" + "partner":"6eq3" }, { "sim":67.0, - "partner":"5nqs" + "partner":"5nqv" }, { "sim":67.0, - "partner":"5nqv" + "partner":"5nqs" }, { "sim":67.0, @@ -270411,11 +271473,11 @@ }, { "sim":66.0, - "partner":"3p86" + "partner":"3ppz" }, { "sim":66.0, - "partner":"3ppz" + "partner":"3p86" }, { "sim":66.0, @@ -270459,7 +271521,7 @@ }, { "sim":65.0, - "partner":"4alj" + "partner":"4alk" }, { "sim":65.0, @@ -270471,15 +271533,11 @@ }, { "sim":65.0, - "partner":"4d43" - }, - { - "sim":65.0, - "partner":"4alk" + "partner":"4cuz" }, { "sim":65.0, - "partner":"4cuz" + "partner":"4d43" }, { "sim":65.0, @@ -270545,6 +271603,10 @@ "sim":65.0, "partner":"4bnl" }, + { + "sim":65.0, + "partner":"4alj" + }, { "sim":65.0, "partner":"5m6r" @@ -270799,11 +271861,11 @@ }, { "sim":53.0, - "partner":"4zb3" + "partner":"4zbp" }, { "sim":53.0, - "partner":"4zbp" + "partner":"4zb3" }, { "sim":53.0, @@ -270947,11 +272009,11 @@ }, { "sim":51.0, - "partner":"5c03" + "partner":"5c01" }, { "sim":51.0, - "partner":"5c01" + "partner":"5c03" }, { "sim":51.0, @@ -270985,17 +272047,13 @@ "sim":51.0, "partner":"4lx0" }, - { - "sim":51.0, - "partner":"5xxq" - }, { "sim":51.0, "partner":"5y1u" }, { "sim":51.0, - "partner":"4uor" + "partner":"5xxq" }, { "sim":51.0, @@ -271003,7 +272061,7 @@ }, { "sim":51.0, - "partner":"4acg" + "partner":"4uor" }, { "sim":51.0, @@ -271017,6 +272075,10 @@ "sim":51.0, "partner":"4acd" }, + { + "sim":51.0, + "partner":"4acg" + }, { "sim":51.0, "partner":"4kpa" @@ -271065,10 +272127,6 @@ "sim":51.0, "partner":"2y3a" }, - { - "sim":51.0, - "partner":"4ovu" - }, { "sim":51.0, "partner":"4ovv" @@ -271149,6 +272207,10 @@ "sim":51.0, "partner":"5sxf" }, + { + "sim":51.0, + "partner":"4ovu" + }, { "sim":51.0, "partner":"5dot" @@ -271410,119 +272472,119 @@ ], "subtitle":"Cryo-em of self-assembly peptide filament lrv_m3delta1", "tags":[ - "filament", "self-assembly peptide filament", "protein fibril", - "cryo-em" + "cryo-em", + "filament" ], "keywords":[ - "analysis", - "analyze", - "independently", - "scaffolds", - "designed", - "exterior", - "reinforce", - "potentially", - "local", - "regarding", - "based", - "solvated", - "sequences", - "basis", - "synthetic", - "interactions", - "hand", + "repeats", + "offers", + "opposite", + "recognition", "adopt", - "similarity", - "conformation", - "opportunity", - "represent", + "structural", "repeat", - "novel", - "direct", - "interfaces", - "resultant", - "proteins", - "employed", - "models", - "filaments", - "similar", - "designability", - "\u00e5", - "characterized", - "detection", - "interface", - "recognition", - "chemically", - "structures", - "thermophilic", - "atomic", - "native", - "motifs", + "single", + "differences", + "addressable", + "maps", + "protein", "significantly", - "exhibit", + "helical", + "electron", + "microscopy", + "axial", + "motifs", + "potentially", + "applications", "heat", - "facilitate", - "consensus", - "nanotubes", - "previously", - "need", - "data", - "ratio", + "similar", + "resultant", + "previous", + "differ", + "construction", + "independently", + "conformation", + "characterized", "respectively", + "interior", + "nanotubes", "release", - "assemblies", - "geometry", - "class", + "regarding", + "surfaces", + "led", + "useful", + "basis", + "proteins", + "packing", + "hand", + "2", + "tandem", + "consensus", + "exterior", + "interface", "lateral", + "cohesive", + "facilitate", + "detection", "surprisingly", + "direct", + "local", + "need", + "exhibit", + "transport", + "atomic", "moreover", - "tandem", - "would", - "surfaces", - "useful", - "engineer", - "biomimetic", - "addressable", - "helical", - "rationalized", - "applications", - "maps", + "represent", + "analyze", + "selective", + "variant", + "thermophilic", + "chemically", + "designability", + "resolutions", "sequence", - "repeats", - "could", "retaining", + "plasticity", + "peptides", "reconstructions", - "opposite", - "packing", - "structural", - "led", - "variant", "3d", - "differ", - "despite", - "construction", - "observations", - "single", + "assemblies", + "engineer", + "could", + "designed", + "employed", + "solvated", + "analysis", + "models", + "sequences", + "interfaces", + "filaments", "afforded", - "axial", - "peptides", - "distinguishable", - "electron", - "selective", - "protein", - "microscopy", - "offers", - "2", - "previous", - "transport", - "resolutions", - "interior", - "differences", - "cohesive", + "geometry", + "structures", + "rationalized", + "previously", + "ratio", + "based", "lrv", - "plasticity" + "\u00e5", + "synthetic", + "scaffolds", + "reinforce", + "interactions", + "biomimetic", + "class", + "would", + "native", + "despite", + "data", + "similarity", + "opportunity", + "distinguishable", + "observations", + "novel" ], "release_date":"2019-06-26", "publication":"\"Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs\", Proc.Natl.Acad.Sci.USA, 116, 14456-14464", @@ -271676,95 +272738,95 @@ ], "subtitle":"Crystal structure of schistosoma mansoni hdac8 complexed with quisinostat", "tags":[ - "epigenetics", + "pathogen", + "hydrolase", "hdac8", - "selective inhibitor", + "epigenetics", "histone deacetylase", - "hydrolase", - "pathogen" + "selective inhibitor" ], "keywords":[ - "least", - "decreases", + "lock", + "engineering", + "molecular", + "adopt", + "structural", + "key", + "show", + "usage", + "collectively", + "single", + "functionally", + "nonspecifically", + "histone", + "tyrosine", + "inhibitor", "results", - "clinical", - "hdac", "shielding", - "inhibitor", - "broad", - "11", - "target", - "show", - "precise", - "conformation", - "adopt", - "represent", - "structurally", + "protein", + "probes", + "binding", + "site", + "regulators", + "catalytic", "affects", - "inhibitors", - "lock", - "therapeutic", - "histone", + "precise", "similar", - "nonspecifically", - "epigenetic", - "l1", - "remains", - "sparse", - "yet", - "currently", - "numerous", - "usage", - "l6", - "functionally", - "unravel", "isozymes", - "targeting", + "conformation", + "terms", "hampers", - "molecular", - "loops", - "functional", - "chemical", - "catalytic", - "hdacs", - "active", - "activity", - "engineering", + "formed", + "epigenetic", + "targets", + "unravel", "several", - "tyrosine", - "design", - "deacetylases", + "broad", + "chemical", "required", - "promising", - "settings", - "key", - "treatment", - "structural", - "important", + "11", + "pocket", + "design", + "decreases", + "sparse", "hdac8", - "single", - "drugs", - "sterically", - "human", + "active", + "loops", + "functional", + "deacetylases", + "represent", + "yet", "different", - "selectivity", - "terms", - "prevents", - "determinants", + "targeting", "selective", - "binding", - "regulators", - "protein", - "targets", + "clinical", + "therapeutic", + "least", "potency", - "collectively", - "probes", + "selectivity", + "hdacs", + "settings", + "promising", + "numerous", + "developed", + "sterically", + "determinants", + "structurally", + "remains", + "important", + "target", + "prevents", + "inhibitors", "understanding", "diseases", - "pocket", - "site", - "developed", - "formed" + "l6", + "l1", + "activity", + "drugs", + "hdac", + "currently", + "human", + "treatment" ], "release_date":"2018-10-31", "publication":"\"Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants\", J. Med. Chem., 61, 10000-10016", @@ -271878,92 +272940,92 @@ ], "subtitle":"Selective formation of trinuclear transition metal centers in a trimeric helical peptide", "tags":[ - "trimeric coiled coil", "de novo protein", - "copper-binding peptide" + "copper-binding peptide", + "trimeric coiled coil" ], "keywords":[ - "coordinates", - "probed", - "complexes", - "metal", - "ions", "trimer", - "crystallography", - "peptide", - "designed", - "cd", - "example", - "crystal", - "ii", + "demonstrates", + "hydrophobic", "show", - "basis", - "designing", - "structure", - "zn", - "discrimination", - "generating", + "complexes", + "unstructured", + "core", + "three", + "cu", + "ni", + "folding", + "cd", + "binding", "coordination", - "involved", - "response", - "influence", - "resulting", - "demonstrates", - "binds", - "nuclear", - "ability", - "assemble", - "trimeric", - "upon", - "construct", "resonance", - "three", - "likely", "circular", - "transition", - "ni", - "form", - "co", - "first", - "analytical", - "stability", - "ratio", - "tests", - "another", - "additionally", - "reveals", - "1", - "introduced", - "core", + "nuclear", + "related", + "hisad", + "crystal", + "binds", + "involved", + "zn", "using", - "hydrophobic", - "selectively", - "nmr", - "histidine", - "one", + "coordinates", + "complex", + "metal", + "formed", + "influence", + "residues", + "transition", "magnetic", - "complexation", - "cu", + "basis", + "stability", + "response", + "ions", + "analytical", + "probed", + "discrimination", "unprecedented", + "construct", + "introduced", + "combination", + "1", + "peptide", + "designing", + "another", + "spectroscopy", + "absence", "fold", + "addition", + "complexation", + "ability", + "upon", + "selectively", + "reveals", "peptides", + "generating", "ultracentrifugation", - "spectroscopy", - "residues", - "absence", - "auc", "folds", - "addition", - "complex", - "hisad", - "unstructured", - "combination", + "co", + "form", + "trimeric", + "designed", + "example", + "one", + "histidine", + "auc", + "first", + "ratio", + "likely", + "structure", + "resulting", + "additionally", + "crystallography", + "nmr", "understanding", + "tests", "dichroism", - "folding", - "binding", - "formed", - "related" + "assemble", + "ii" ], "release_date":"2019-09-04", "publication":"\"Selective coordination of three transition metal ions within a coiled-coil peptide scaffold\", Chem Sci, 10, 7456-7465", @@ -272205,98 +273267,98 @@ ], "subtitle":"Crystal structure of nv1pizza6-ayw, a circularly permuted designer protein", "tags":[ - "beta-propeller", "circularly permuted designer protein", - "artificial protein", "de novo protein", - "pizza" + "beta-propeller", + "pizza", + "artificial protein" ], "keywords":[ - "thermal", - "part", - "bonds", - "lacking", - "variable", - "improved", - "mostly", - "referred", - "order", - "denaturation", - "rarely", - "interactions", + "repeats", + "interestingly", "adopt", - "structure", + "hydrophobic", + "additional", "repeat", - "permutants", + "positioning", + "rotational", + "explain", + "within", + "provided", + "folding", + "symmetrical", + "adopted", + "protein", + "six", + "significantly", + "stabilization", "velcro", + "circularized", + "depends", + "location", + "circular", + "applications", + "stable", + "referred", "invariably", - "proteins", - "family", - "feature", - "variants", + "shows", + "perfectly", + "pizza", "almost", - "less", - "dramatically", "influence", - "version", - "nature", - "often", - "symmetrical", - "pizza", - "perfectly", - "future", - "circular", - "significantly", - "blade", + "permutants", + "family", + "thermal", + "denaturation", + "stability", + "proteins", + "part", "mutants", - "additional", - "shows", "hydrogen", - "designer", - "provided", + "sequentially", + "found", "created", - "investigate", - "rotational", - "stability", - "propeller", - "depends", "chemical", - "common", - "among", - "possessing", + "future", + "termini", + "investigate", + "variable", "configuration", - "six", - "sequentially", - "observed", - "closure", - "interestingly", - "apparent", - "applications", - "hydrophobic", "symmetry", - "stabilized", - "repeats", - "could", - "adopted", - "stabilization", + "propeller", "diverse", - "tested", - "positioning", - "stable", + "feature", "named", - "fold", "different", - "found", - "circularized", - "implications", - "explain", - "protein", - "termini", + "possessing", + "tested", + "fold", + "bonds", + "improved", + "closure", + "designer", + "common", "identical", + "implications", + "mostly", + "could", + "often", + "order", + "variants", + "observed", "resistant", - "within", - "location", - "folding" + "apparent", + "structure", + "among", + "interactions", + "nature", + "version", + "dramatically", + "rarely", + "blade", + "lacking", + "less", + "stabilized" ], "release_date":"2019-11-20", "publication":"\"Influence of circular permutations on the structure and stability of a six-fold circular symmetric designer protein\", Protein Sci.", @@ -272361,43 +273423,43 @@ }, { "sim":469.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":469.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":469.0, - "partner":"7zpz" + "partner":"6qse" }, { "sim":469.0, - "partner":"7ov7" + "partner":"6reg" }, { "sim":469.0, - "partner":"6rei" + "partner":"6qsf" }, { "sim":469.0, - "partner":"6qsf" + "partner":"6qsg" }, { "sim":469.0, - "partner":"6reh" + "partner":"6qsh" }, { "sim":469.0, - "partner":"6qsg" + "partner":"6qsd" }, { "sim":469.0, - "partner":"6qsd" + "partner":"7zpz" }, { "sim":469.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":468.0, @@ -272413,15 +273475,15 @@ }, { "sim":464.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":464.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":464.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":464.0, @@ -272433,11 +273495,11 @@ }, { "sim":439.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":439.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":439.0, @@ -272445,7 +273507,7 @@ }, { "sim":439.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":170.0, @@ -272457,11 +273519,11 @@ }, { "sim":169.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":169.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":168.0, @@ -272471,11 +273533,11 @@ "seq_thr_sim_natural":[ { "sim":319.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":319.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":91.0, @@ -272570,7 +273632,7 @@ }, "seq_max_sim_natural":{ "sim":319.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.940500021, @@ -272632,98 +273694,98 @@ ], "subtitle":"Crystal structure of nv2pizza6-ayw, a circularly permuted designer protein", "tags":[ - "beta-propeller", "circularly permuted designer protein", - "artificial protein", "de novo protein", - "pizza" + "beta-propeller", + "pizza", + "artificial protein" ], "keywords":[ - "thermal", - "part", - "bonds", - "lacking", - "variable", - "improved", - "mostly", - "referred", - "order", - "denaturation", - "rarely", - "interactions", + "repeats", + "interestingly", "adopt", - "structure", + "hydrophobic", + "additional", "repeat", - "permutants", + "positioning", + "rotational", + "explain", + "within", + "provided", + "folding", + "symmetrical", + "adopted", + "protein", + "six", + "significantly", + "stabilization", "velcro", + "circularized", + "depends", + "location", + "circular", + "applications", + "stable", + "referred", "invariably", - "proteins", - "family", - "feature", - "variants", + "shows", + "perfectly", + "pizza", "almost", - "less", - "dramatically", "influence", - "version", - "nature", - "often", - "symmetrical", - "pizza", - "perfectly", - "future", - "circular", - "significantly", - "blade", + "permutants", + "family", + "thermal", + "denaturation", + "stability", + "proteins", + "part", "mutants", - "additional", - "shows", "hydrogen", - "designer", - "provided", + "sequentially", + "found", "created", - "investigate", - "rotational", - "stability", - "propeller", - "depends", "chemical", - "common", - "among", - "possessing", + "future", + "termini", + "investigate", + "variable", "configuration", - "six", - "sequentially", - "observed", - "closure", - "interestingly", - "apparent", - "applications", - "hydrophobic", "symmetry", - "stabilized", - "repeats", - "could", - "adopted", - "stabilization", + "propeller", "diverse", - "tested", - "positioning", - "stable", + "feature", "named", - "fold", "different", - "found", - "circularized", - "implications", - "explain", - "protein", - "termini", + "possessing", + "tested", + "fold", + "bonds", + "improved", + "closure", + "designer", + "common", "identical", + "implications", + "mostly", + "could", + "often", + "order", + "variants", + "observed", "resistant", - "within", - "location", - "folding" + "apparent", + "structure", + "among", + "interactions", + "nature", + "version", + "dramatically", + "rarely", + "blade", + "lacking", + "less", + "stabilized" ], "release_date":"2019-11-20", "publication":"\"Influence of circular permutations on the structure and stability of a six-fold circular symmetric designer protein\", Protein Sci.", @@ -272788,43 +273850,43 @@ }, { "sim":462.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":462.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":462.0, - "partner":"7zpz" + "partner":"6qse" }, { "sim":462.0, - "partner":"7ov7" + "partner":"6reg" }, { "sim":462.0, - "partner":"6rei" + "partner":"6qsf" }, { "sim":462.0, - "partner":"6qsf" + "partner":"6qsg" }, { "sim":462.0, - "partner":"6reh" + "partner":"6qsh" }, { "sim":462.0, - "partner":"6qsg" + "partner":"6qsd" }, { "sim":462.0, - "partner":"6qsd" + "partner":"7zpz" }, { "sim":462.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":461.0, @@ -272840,15 +273902,15 @@ }, { "sim":456.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":456.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":456.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":456.0, @@ -272860,11 +273922,11 @@ }, { "sim":432.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":432.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":432.0, @@ -272872,7 +273934,7 @@ }, { "sim":432.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":162.0, @@ -272884,25 +273946,25 @@ }, { "sim":160.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":160.0, - "partner":"5chb" + "partner":"5i1y" }, { "sim":160.0, - "partner":"5i1z" + "partner":"5chb" } ], "seq_thr_sim_natural":[ { "sim":316.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":316.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":91.0, @@ -272997,7 +274059,7 @@ }, "seq_max_sim_natural":{ "sim":316.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.945200026, @@ -273059,98 +274121,98 @@ ], "subtitle":"Crystal structure of v31pizza6-ayw, a circularly permuted designer protein", "tags":[ - "beta-propeller", "circularly permuted designer protein", - "artificial protein", "de novo protein", - "pizza" + "beta-propeller", + "pizza", + "artificial protein" ], "keywords":[ - "thermal", - "part", - "bonds", - "lacking", - "variable", - "improved", - "mostly", - "referred", - "order", - "denaturation", - "rarely", - "interactions", + "repeats", + "interestingly", "adopt", - "structure", + "hydrophobic", + "additional", "repeat", - "permutants", + "positioning", + "rotational", + "explain", + "within", + "provided", + "folding", + "symmetrical", + "adopted", + "protein", + "six", + "significantly", + "stabilization", "velcro", + "circularized", + "depends", + "location", + "circular", + "applications", + "stable", + "referred", "invariably", - "proteins", - "family", - "feature", - "variants", + "shows", + "perfectly", + "pizza", "almost", - "less", - "dramatically", "influence", - "version", - "nature", - "often", - "symmetrical", - "pizza", - "perfectly", - "future", - "circular", - "significantly", - "blade", + "permutants", + "family", + "thermal", + "denaturation", + "stability", + "proteins", + "part", "mutants", - "additional", - "shows", "hydrogen", - "designer", - "provided", + "sequentially", + "found", "created", - "investigate", - "rotational", - "stability", - "propeller", - "depends", "chemical", - "common", - "among", - "possessing", + "future", + "termini", + "investigate", + "variable", "configuration", - "six", - "sequentially", - "observed", - "closure", - "interestingly", - "apparent", - "applications", - "hydrophobic", "symmetry", - "stabilized", - "repeats", - "could", - "adopted", - "stabilization", + "propeller", "diverse", - "tested", - "positioning", - "stable", + "feature", "named", - "fold", "different", - "found", - "circularized", - "implications", - "explain", - "protein", - "termini", + "possessing", + "tested", + "fold", + "bonds", + "improved", + "closure", + "designer", + "common", "identical", + "implications", + "mostly", + "could", + "often", + "order", + "variants", + "observed", "resistant", - "within", - "location", - "folding" + "apparent", + "structure", + "among", + "interactions", + "nature", + "version", + "dramatically", + "rarely", + "blade", + "lacking", + "less", + "stabilized" ], "release_date":"2019-11-20", "publication":"\"Influence of circular permutations on the structure and stability of a six-fold circular symmetric designer protein\", Protein Sci.", @@ -273219,19 +274281,19 @@ }, { "sim":445.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":445.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":445.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":445.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":445.0, @@ -273239,11 +274301,11 @@ }, { "sim":445.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":445.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":445.0, @@ -273251,7 +274313,7 @@ }, { "sim":445.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":442.0, @@ -273267,15 +274329,15 @@ }, { "sim":439.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":439.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":439.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":439.0, @@ -273287,11 +274349,11 @@ }, { "sim":414.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":414.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":414.0, @@ -273299,7 +274361,7 @@ }, { "sim":414.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":162.0, @@ -273311,25 +274373,25 @@ }, { "sim":160.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":160.0, - "partner":"5chb" + "partner":"5i1y" }, { "sim":160.0, - "partner":"5i1z" + "partner":"5chb" } ], "seq_thr_sim_natural":[ { "sim":307.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":307.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":85.0, @@ -273372,7 +274434,7 @@ }, "seq_max_sim_natural":{ "sim":307.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9113000035, @@ -273434,98 +274496,98 @@ ], "subtitle":"Crystal structure of v22pizza6-ayw, a circularly permuted designer protein", "tags":[ - "beta-propeller", "circularly permuted designer protein", - "artificial protein", "de novo protein", - "pizza" + "beta-propeller", + "pizza", + "artificial protein" ], "keywords":[ - "thermal", - "part", - "bonds", - "lacking", - "variable", - "improved", - "mostly", - "referred", - "order", - "denaturation", - "rarely", - "interactions", + "repeats", + "interestingly", "adopt", - "structure", + "hydrophobic", + "additional", "repeat", - "permutants", + "positioning", + "rotational", + "explain", + "within", + "provided", + "folding", + "symmetrical", + "adopted", + "protein", + "six", + "significantly", + "stabilization", "velcro", + "circularized", + "depends", + "location", + "circular", + "applications", + "stable", + "referred", "invariably", - "proteins", - "family", - "feature", - "variants", + "shows", + "perfectly", + "pizza", "almost", - "less", - "dramatically", "influence", - "version", - "nature", - "often", - "symmetrical", - "pizza", - "perfectly", - "future", - "circular", - "significantly", - "blade", + "permutants", + "family", + "thermal", + "denaturation", + "stability", + "proteins", + "part", "mutants", - "additional", - "shows", "hydrogen", - "designer", - "provided", + "sequentially", + "found", "created", - "investigate", - "rotational", - "stability", - "propeller", - "depends", "chemical", - "common", - "among", - "possessing", + "future", + "termini", + "investigate", + "variable", "configuration", - "six", - "sequentially", - "observed", - "closure", - "interestingly", - "apparent", - "applications", - "hydrophobic", "symmetry", - "stabilized", - "repeats", - "could", - "adopted", - "stabilization", + "propeller", "diverse", - "tested", - "positioning", - "stable", + "feature", "named", - "fold", "different", - "found", - "circularized", - "implications", - "explain", - "protein", - "termini", + "possessing", + "tested", + "fold", + "bonds", + "improved", + "closure", + "designer", + "common", "identical", + "implications", + "mostly", + "could", + "often", + "order", + "variants", + "observed", "resistant", - "within", - "location", - "folding" + "apparent", + "structure", + "among", + "interactions", + "nature", + "version", + "dramatically", + "rarely", + "blade", + "lacking", + "less", + "stabilized" ], "release_date":"2019-11-20", "publication":"\"Influence of circular permutations on the structure and stability of a six-fold circular symmetric designer protein\", Protein Sci.", @@ -273590,43 +274652,43 @@ }, { "sim":463.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":463.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":463.0, - "partner":"7zpz" + "partner":"6qse" }, { "sim":463.0, - "partner":"7ov7" + "partner":"6reg" }, { "sim":463.0, - "partner":"6rei" + "partner":"6qsf" }, { "sim":463.0, - "partner":"6qsf" + "partner":"6qsg" }, { "sim":463.0, - "partner":"6reh" + "partner":"6qsh" }, { "sim":463.0, - "partner":"6qsg" + "partner":"6qsd" }, { "sim":463.0, - "partner":"6qsd" + "partner":"7zpz" }, { "sim":463.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":462.0, @@ -273642,15 +274704,15 @@ }, { "sim":457.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":457.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":457.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":457.0, @@ -273662,11 +274724,11 @@ }, { "sim":432.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":432.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":432.0, @@ -273674,7 +274736,7 @@ }, { "sim":432.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":162.0, @@ -273686,25 +274748,25 @@ }, { "sim":160.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":160.0, - "partner":"5chb" + "partner":"5i1y" }, { "sim":160.0, - "partner":"5i1z" + "partner":"5chb" } ], "seq_thr_sim_natural":[ { "sim":314.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":314.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":84.0, @@ -273787,7 +274849,7 @@ }, "seq_max_sim_natural":{ "sim":314.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9301999807, @@ -273849,98 +274911,98 @@ ], "subtitle":"Crystal structure of cpizza6-ayw, a circularly permuted designer protein", "tags":[ - "beta-propeller", "circularly permuted designer protein", - "artificial protein", "de novo protein", - "pizza" + "beta-propeller", + "pizza", + "artificial protein" ], "keywords":[ - "thermal", - "part", - "bonds", - "lacking", - "variable", - "improved", - "mostly", - "referred", - "order", - "denaturation", - "rarely", - "interactions", + "repeats", + "interestingly", "adopt", - "structure", + "hydrophobic", + "additional", "repeat", - "permutants", + "positioning", + "rotational", + "explain", + "within", + "provided", + "folding", + "symmetrical", + "adopted", + "protein", + "six", + "significantly", + "stabilization", "velcro", + "circularized", + "depends", + "location", + "circular", + "applications", + "stable", + "referred", "invariably", - "proteins", - "family", - "feature", - "variants", + "shows", + "perfectly", + "pizza", "almost", - "less", - "dramatically", "influence", - "version", - "nature", - "often", - "symmetrical", - "pizza", - "perfectly", - "future", - "circular", - "significantly", - "blade", + "permutants", + "family", + "thermal", + "denaturation", + "stability", + "proteins", + "part", "mutants", - "additional", - "shows", "hydrogen", - "designer", - "provided", + "sequentially", + "found", "created", - "investigate", - "rotational", - "stability", - "propeller", - "depends", "chemical", - "common", - "among", - "possessing", + "future", + "termini", + "investigate", + "variable", "configuration", - "six", - "sequentially", - "observed", - "closure", - "interestingly", - "apparent", - "applications", - "hydrophobic", "symmetry", - "stabilized", - "repeats", - "could", - "adopted", - "stabilization", + "propeller", "diverse", - "tested", - "positioning", - "stable", + "feature", "named", - "fold", "different", - "found", - "circularized", - "implications", - "explain", - "protein", - "termini", + "possessing", + "tested", + "fold", + "bonds", + "improved", + "closure", + "designer", + "common", "identical", + "implications", + "mostly", + "could", + "often", + "order", + "variants", + "observed", "resistant", - "within", - "location", - "folding" + "apparent", + "structure", + "among", + "interactions", + "nature", + "version", + "dramatically", + "rarely", + "blade", + "lacking", + "less", + "stabilized" ], "release_date":"2019-11-20", "publication":"\"Influence of circular permutations on the structure and stability of a six-fold circular symmetric designer protein\", Protein Sci.", @@ -273997,51 +275059,51 @@ }, { "sim":483.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":483.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":483.0, - "partner":"7zpz" + "partner":"6qse" }, { "sim":483.0, - "partner":"7ov7" + "partner":"6reg" }, { "sim":483.0, - "partner":"6rei" + "partner":"6qsf" }, { "sim":483.0, - "partner":"6qsf" + "partner":"6qsg" }, { "sim":483.0, - "partner":"6reh" + "partner":"6qsh" }, { "sim":483.0, - "partner":"6qsg" + "partner":"6qsd" }, { "sim":483.0, - "partner":"6qsd" + "partner":"7zpz" }, { "sim":483.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":482.0, - "partner":"6i3a" + "partner":"6i38" }, { "sim":482.0, - "partner":"6i38" + "partner":"6i3a" }, { "sim":482.0, @@ -274053,15 +275115,15 @@ }, { "sim":477.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":477.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":477.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":477.0, @@ -274077,11 +275139,11 @@ }, { "sim":452.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":452.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":452.0, @@ -274089,7 +275151,7 @@ }, { "sim":452.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":162.0, @@ -274101,25 +275163,25 @@ }, { "sim":160.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":160.0, - "partner":"5chb" + "partner":"5i1y" }, { "sim":160.0, - "partner":"5i1z" + "partner":"5chb" } ], "seq_thr_sim_natural":[ { "sim":329.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":329.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":91.0, @@ -274221,7 +275283,7 @@ }, "seq_max_sim_natural":{ "sim":329.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9641000032, @@ -274330,74 +275392,74 @@ "apoptosis" ], "keywords":[ + "solid", + "designed", + "improve", + "heterodimeric", + "risk", + "design", + "signaling", + "endodomain", + "compared", + "vivo", + "chimeric", + "chain", "work", - "cdh", - "administration", + "tumors", + "controllable", + "approaches", + "computationally", "highlights", + "side", + "based", + "potential", + "tested", + "deviation", "inactivated", + "specific", + "synthetic", + "acid", + "antigen", + "heterodimer", + "safety", "called", - "chain", - "dynamically", - "improve", - "therapy", - "car", - "tested", - "amino", - "proteins", "incorporated", - "timed", - "antigens", - "similar", "also", - "antigen", - "signaling", - "therapies", + "antigens", + "add", "elements", - "acid", + "therapies", + "protein", + "disruptable", + "chemically", + "amino", + "toxicity", "drug", - "human", - "disrupted", - "designed", - "solid", - "receptor", + "proteins", + "vitro", + "binding", + "dynamically", + "2g", + "cellular", "may", - "deviation", - "heterodimeric", + "cells", + "activity", + "timed", "interface", - "approaches", + "disrupted", + "therapy", "found", - "add", "two", - "activity", - "specific", - "vitro", - "heterodimer", - "endodomain", - "potential", - "chemically", - "safety", - "based", - "design", - "protein", - "toxicity", - "synthetic", - "controllable", + "car", "antitumor", - "cellular", - "computationally", + "effects", + "cdh", + "human", "minimal", - "2g", + "similar", + "receptor", "increase", - "effects", - "disruptable", - "vivo", - "risk", - "cells", - "chimeric", - "side", - "compared", - "binding", - "tumors" + "administration" ], "release_date":"2019-12-11", "publication":"\"A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy\", Nat.Biotechnol., 38, 426-432", @@ -274487,8 +275549,8 @@ ], "subtitle":"Structure of a de novo protein d_1cy5_m1", "tags":[ - "designed protein evolution crystal structure helix", - "de novo protein" + "de novo protein", + "designed protein evolution crystal structure helix" ], "keywords":[ "description", @@ -274600,98 +275662,98 @@ ], "subtitle":"Crystal structure of suwa (super wa20), a hyper-stable de novo protein with a dimeric bisecting topology", "tags":[ - "bisecting u topology", - "thermostable protein design", "four helix bundle", - "3d domain swapping", "de novo protein", - "binary patterned design" + "3d domain swapping", + "thermostable protein design", + "binary patterned design", + "bisecting u topology" ], "keywords":[ - "protomer", - "deformation", - "long", - "stabilizing", + "pillars", + "molecular", + "hydrophobic", + "hyperstable", "complexes", - "nanobuilding", - "including", - "substantially", - "midpoints", - "designed", - "denature", - "mutations", - "dimeric", - "intermolecularly", - "suwa", - "crystal", - "extremely", + "nanoarchitectures", + "core", + "new", "assembled", - "bisecting", - "suppresses", - "designing", - "structure", - "recently", - "wa20", - "pillars", - "parental", - "called", - "topology", - "suggesting", - "proteins", - "redesigned", - "similar", - "intertwined", - "de", - "midpoint", - "nanostructures", - "folded", - "75", - "dynamics", - "center", + "protein", "significantly", - "much", - "series", - "molecular", - "u", + "stabilization", + "super", + "novo", + "demonstrate", "expected", - "another", - "reveals", - "higher", - "components", - "useful", - "dimer", + "75", + "two", + "crystal", + "stable", "region", + "helices", + "parental", + "midpoints", + "using", + "similar", + "deformation", + "supramolecular", "simulations", - "super", "nanoscale", - "blocks", - "bundle", - "stabilize", - "observed", - "core", - "using", - "hydrophobic", + "nanostructures", + "stabilizing", + "dimer", + "intermolecularly", "122", - "describe", - "high", - "stabilization", - "variant", - "supramolecular", - "demonstrate", + "nanobuilding", + "useful", + "folded", + "extremely", + "blocks", + "constructed", + "proteins", "factor", + "center", + "components", + "suggesting", + "higher", + "stabilize", + "long", + "bundle", + "including", + "designing", + "wa20", "critical", - "helices", - "novo", - "stable", - "constructed", - "displaying", - "two", - "nanoarchitectures", - "protein", + "redesigned", + "another", + "topology", + "called", + "variant", + "denature", + "midpoint", + "series", "types", - "hyperstable", "polyhedra", - "new" + "reveals", + "substantially", + "describe", + "suwa", + "dynamics", + "designed", + "displaying", + "u", + "mutations", + "observed", + "de", + "intertwined", + "structure", + "recently", + "high", + "much", + "suppresses", + "protomer", + "bisecting", + "dimeric" ], "release_date":"2020-01-29", "publication":"\"HyperstableDe NovoProtein with a Dimeric Bisecting Topology\", Acs Synth Biol, 9, 254-259", @@ -274728,15 +275790,15 @@ }, { "sim":103.0, - "partner":"8h7d" + "partner":"8h7e" }, { "sim":103.0, - "partner":"8h7e" + "partner":"8h7c" }, { "sim":103.0, - "partner":"8h7c" + "partner":"8h7d" } ], "seq_thr_sim_natural":[ @@ -274893,113 +275955,113 @@ "subtitle":"A de novo designed transmembrane nanopore, tmh4c4", "tags":[ "nanopore", - "membrane protein", "de novo protein", + "membrane protein", "de novo design" ], "keywords":[ - "concentric", - "opens", - "fluorophores", - "matches", - "channels", - "ions", - "challenge", - "door", - "expressed", - "roles", - "crystal", - "alexa", - "fluor", + "biotechnological", + "biotinylated", + "488", + "key", "show", - "synthetic", - "pores", - "passage", - "structure", - "structurally", - "sequencing", - "however", - "modification", - "proteins", - "membrane", - "models", - "dna", - "enables", - "de", "outstanding", - "produce", - "amphiphilic", - "rings", + "functionally", "pore", - "processes", - "resulting", - "remains", - "liposomes", + "roles", + "model", + "protein", + "insect", "vitro", - "occurring", - "ability", + "across", + "microscopy", + "novo", + "cells", "match", + "forms", + "amphiphilic", + "two", + "variety", + "applications", + "recent", + "crystal", + "stable", + "door", + "using", + "occurring", + "monodisperse", "enough", - "structures", - "naturally", - "biotechnological", - "potassium", - "biotinylated", - "transmembrane", - "form", - "functionally", - "designer", - "considerable", - "entrance", + "enables", + "however", + "formed", + "interest", + "creation", + "dna", + "biological", + "specific", "incorporated", + "matches", + "entrance", + "conducting", + "proteins", "large", - "chemical", - "report", + "capable", + "ions", "blocked", + "alexa", + "found", + "chemical", + "electrophysiology", + "computational", "1", - "redesigning", - "interest", - "conducting", - "closely", - "synthesis", - "specific", + "concentric", "advances", - "488", - "insect", "design", - "model", - "using", - "applications", - "nanopore", - "selectively", - "across", - "recent", - "high", - "biological", - "key", - "cells", "sodium", - "ion", - "fundamental", - "monodisperse", - "novo", - "stable", - "wide", + "produce", + "processes", + "nanopore", + "synthesis", "experiments", + "selectivity", + "wide", + "liposomes", + "ability", + "sequencing", + "fluor", + "designer", + "selectively", + "channels", "peptides", + "potassium", + "pores", + "fundamental", + "form", + "fluorophores", + "models", + "naturally", + "modification", + "transmembrane", + "opens", + "structurally", + "structures", + "de", + "expressed", + "remains", + "structure", + "synthetic", + "report", + "resulting", + "closely", + "ion", + "membrane", + "redesigning", "enable", - "capable", - "found", - "selectivity", - "two", - "creation", - "protein", - "microscopy", - "electrophysiology", - "variety", - "computational", - "formed", - "forms" + "passage", + "considerable", + "high", + "rings", + "challenge" ], "release_date":"2020-06-24", "publication":"\"Computational design of transmembrane pores\", Nature, 585, 129-134", @@ -275117,102 +276179,102 @@ ], "subtitle":"Crystal structure of tris-thiolate pb(ii) complex with adjacent water in a de novo three stranded coiled coil peptide", "tags":[ - "metallopeptide de novo design", - "de novo protein" + "de novo protein", + "metallopeptide de novo design" ], "keywords":[ - "prepare", - "amphipathic", - "characteristics", - "heptad", + "pure", + "repeats", "steric", - "specificity", - "pyramidal", + "demanding", + "hydrophobic", + "show", + "cavity", + "perturbed", + "trigonal", + "heterotrimeric", + "combining", + "three", + "within", "strategy", - "metal", - "scaffolds", + "dissymmetric", "pb", - "peptide", "cd", + "perturbing", + "layers", + "thiophilic", + "coordination", + "site", + "b", + "location", + "catalytic", + "two", + "substitution", + "binds", "hg", - "provide", - "show", - "ii", - "regions", - "position", - "metalloid", - "c", + "adjacent", "zn", - "heterotrimeric", - "sulfurs", - "bulk", - "demanding", - "dissymmetric", - "combining", - "coiled", - "generating", "centre", - "shifting", - "without", - "suggesting", - "proteins", - "trigonal", - "coordination", - "perturbing", - "unique", - "de", - "h", - "less", - "atoms", - "binds", - "3", - "remote", - "cavity", + "prepare", + "water", + "metal", + "specificity", + "bulk", + "heterotrimers", + "relative", + "metalloid", + "incorporated", + "layer", "heterotrimer", - "structures", - "coils", - "three", - "form", - "layers", - "removes", + "constructed", + "sites", + "proteins", + "eight", + "sulfur", + "2", "hydrogen", - "layer", - "yields", - "substitution", - "incorporated", - "catalytic", - "altering", - "heterotrimers", - "1", - "introduced", - "reduced", + "scaffold", "bond", - "hydrophobic", - "repeats", - "histidine", - "sulfur", - "sites", + "suggesting", + "coils", + "introduced", + "regions", + "1", + "peptide", + "heptad", + "c", + "ten", + "possible", + "pyramidal", + "atoms", "cysteine", - "eight", - "thiophilic", - "sterically", - "constructed", - "adjacent", + "shifting", "selectivity", - "two", - "scaffold", - "b", - "2", - "water", - "pure", + "reduced", + "generating", + "altering", + "unique", + "amphipathic", + "characteristics", + "sterically", + "form", + "h", + "sulfurs", + "histidine", + "structures", + "de", + "yields", + "3", + "without", + "scaffolds", + "provide", + "coiled", "distinct", - "within", - "perturbed", - "location", - "possible", - "relative", - "site", - "ten" + "position", + "removes", + "less", + "remote", + "ii" ], "release_date":"2020-03-04", "publication":"\"Heteromeric three-stranded coiled coils designed using a Pb(II)(Cys)3template mediated strategy\", Nat.Chem., 12, 405-411", @@ -275249,11 +276311,11 @@ }, { "sim":64.0, - "partner":"6egp" + "partner":"5kb2" }, { "sim":64.0, - "partner":"5kb2" + "partner":"6egp" }, { "sim":63.0, @@ -275269,11 +276331,11 @@ }, { "sim":61.0, - "partner":"5kb1" + "partner":"7n2y" }, { "sim":61.0, - "partner":"7n2y" + "partner":"5kb1" }, { "sim":61.0, @@ -275404,80 +276466,80 @@ "protein design" ], "keywords":[ - "evolution", - "poorly", - "chains", - "simulation", - "stringent", - "alone", - "conform", "membranes", - "proteins", - "membrane", - "entirely", - "proteome", - "steric", - "remain", + "designed", + "conform", "complementarity", - "stable", - "although", - "apolar", - "feature", + "redesign", + "shows", + "poorly", + "steric", + "role", + "hydrophobic", + "stringent", + "structural", + "prominent", + "destabilize", "variants", - "lipids", - "fold", - "sufficient", + "structurally", + "structures", + "feature", + "natural", "phospholamban", - "disruption", - "designed", + "apolar", + "side", "define", - "surprisingly", - "code", - "highly", - "emphasizing", - "understood", - "modestly", - "little", - "motif", - "folds", - "energetics", + "contribute", + "effect", + "recurs", + "assembly", + "synthetic", + "fold", "polar", - "stabilize", - "features", + "although", + "folding", + "code", "drive", - "structures", + "intended", "interactions", - "contributes", + "lipids", + "readily", "protein", - "synthetic", - "using", - "hydrophobic", + "contributes", + "emphasizing", + "membrane", "required", - "effect", - "natural", - "recurs", + "proteome", + "proteins", + "packing", + "little", + "achieved", "across", + "motif", + "stabilization", + "understood", + "energetics", + "modestly", + "underlying", + "entirely", + "native", + "remain", + "highly", + "sufficient", + "evolution", "precise", + "stable", + "disruption", + "stabilize", + "features", + "chains", "informatics", + "using", + "folds", + "simulation", + "alone", "stabilized", - "readily", - "structurally", - "native", - "redesign", - "underlying", - "assembly", - "intended", - "prominent", - "destabilize", - "shows", - "achieved", - "side", - "folding", - "contribute", - "packing", - "role", - "structural", - "stabilization" + "surprisingly" ], "release_date":"2019-04-03", "publication":"\"Packing of apolar side chains enables accurate design of highly stable membrane proteins\", Science, 363, 1418-1423", @@ -275518,25 +276580,25 @@ "sim":1.0, "partner":"7udy" }, - { - "sim":0.9879999757, - "partner":"6mq2" - }, { "sim":1.0, "partner":"6mpw" }, + { + "sim":0.9879999757, + "partner":"6mq2" + }, { "sim":0.9980999827, "partner":"7udw" }, { "sim":0.9505000114, - "partner":"7udv" + "partner":"7udz" }, { "sim":0.9505000114, - "partner":"7udz" + "partner":"7udv" }, { "sim":0.9505000114, @@ -275548,7 +276610,7 @@ ], "seq_max_sim_designed":{ "sim":43.0, - "partner":"6mpw" + "partner":"6mq2" }, "seq_max_sim_natural":[ @@ -275628,118 +276690,118 @@ ], "subtitle":"Cryo-em of self-assembly peptide filament heat_r1", "tags":[ - "filament", "self-assembly peptide filament", - "protein fibril" + "protein fibril", + "filament" ], "keywords":[ - "analysis", - "analyze", - "independently", - "scaffolds", - "designed", - "exterior", - "reinforce", - "potentially", - "local", - "regarding", - "based", - "solvated", - "sequences", - "basis", - "synthetic", - "interactions", - "hand", + "repeats", + "offers", + "opposite", + "recognition", "adopt", - "similarity", - "conformation", - "opportunity", - "represent", + "structural", "repeat", - "novel", - "direct", - "interfaces", - "resultant", - "proteins", - "employed", - "models", - "filaments", - "similar", - "designability", - "\u00e5", - "characterized", - "detection", - "interface", - "recognition", - "chemically", - "structures", - "thermophilic", - "atomic", - "native", - "motifs", + "single", + "differences", + "addressable", + "maps", + "protein", "significantly", - "exhibit", + "helical", + "electron", + "microscopy", + "axial", + "motifs", + "potentially", + "applications", "heat", - "facilitate", - "consensus", - "nanotubes", - "previously", - "need", - "data", - "ratio", + "similar", + "resultant", + "previous", + "differ", + "construction", + "independently", + "conformation", + "characterized", "respectively", + "interior", + "nanotubes", "release", - "assemblies", - "geometry", - "class", + "regarding", + "surfaces", + "led", + "useful", + "basis", + "proteins", + "packing", + "hand", + "2", + "tandem", + "consensus", + "exterior", + "interface", "lateral", + "cohesive", + "facilitate", + "detection", "surprisingly", + "direct", + "local", + "need", + "exhibit", + "transport", + "atomic", "moreover", - "tandem", - "would", - "surfaces", - "useful", - "engineer", - "biomimetic", - "addressable", - "helical", - "rationalized", - "applications", - "maps", + "represent", + "analyze", + "selective", + "variant", + "thermophilic", + "chemically", + "designability", + "resolutions", "sequence", - "repeats", - "could", "retaining", + "plasticity", + "peptides", "reconstructions", - "opposite", - "packing", - "structural", - "led", - "variant", "3d", - "differ", - "despite", - "construction", - "observations", - "single", + "assemblies", + "engineer", + "could", + "designed", + "employed", + "solvated", + "analysis", + "models", + "sequences", + "interfaces", + "filaments", "afforded", - "axial", - "peptides", - "distinguishable", - "electron", - "selective", - "protein", - "microscopy", - "offers", - "2", - "previous", - "transport", - "resolutions", - "interior", - "differences", - "cohesive", + "geometry", + "structures", + "rationalized", + "previously", + "ratio", + "based", "lrv", - "plasticity" + "\u00e5", + "synthetic", + "scaffolds", + "reinforce", + "interactions", + "biomimetic", + "class", + "would", + "native", + "despite", + "data", + "similarity", + "opportunity", + "distinguishable", + "observations", + "novel" ], "release_date":"2019-06-26", "publication":"\"Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs\", Proc.Natl.Acad.Sci.USA, 116, 14456-14464", @@ -275846,86 +276908,86 @@ ], "subtitle":"De novo design of membrane protein--mini-evgl membrane protein, c2221 form-1", "tags":[ - "pentameric bundle", "membrane protein", "de novo protein", + "pentameric bundle", "de novo design" ], "keywords":[ - "evolution", - "poorly", - "chains", - "simulation", - "stringent", - "alone", - "conform", "membranes", - "proteins", - "membrane", - "entirely", - "proteome", - "steric", - "remain", + "designed", + "conform", "complementarity", - "stable", - "although", - "apolar", - "feature", + "redesign", + "shows", + "poorly", + "steric", + "role", + "hydrophobic", + "stringent", + "structural", + "prominent", + "destabilize", "variants", - "lipids", - "fold", - "sufficient", + "structurally", + "structures", + "feature", + "natural", "phospholamban", - "disruption", - "designed", + "apolar", + "side", "define", - "surprisingly", - "code", - "highly", - "emphasizing", - "understood", - "modestly", - "little", - "motif", - "folds", - "energetics", + "contribute", + "effect", + "recurs", + "assembly", + "synthetic", + "fold", "polar", - "stabilize", - "features", + "although", + "folding", + "code", "drive", - "structures", + "intended", "interactions", - "contributes", + "lipids", + "readily", "protein", - "synthetic", - "using", - "hydrophobic", + "contributes", + "emphasizing", + "membrane", "required", - "effect", - "natural", - "recurs", + "proteome", + "proteins", + "packing", + "little", + "achieved", "across", + "motif", + "stabilization", + "understood", + "energetics", + "modestly", + "underlying", + "entirely", + "native", + "remain", + "highly", + "sufficient", + "evolution", "precise", + "stable", + "disruption", + "stabilize", + "features", + "chains", "informatics", + "using", + "folds", + "simulation", + "alone", "stabilized", - "readily", - "structurally", - "native", - "redesign", - "underlying", - "assembly", - "intended", - "prominent", - "destabilize", - "shows", - "achieved", - "side", - "folding", - "contribute", - "packing", - "role", - "structural", - "stabilization" + "surprisingly" ], "release_date":"2019-04-03", "publication":"\"Packing of apolar side chains enables accurate design of highly stable membrane proteins\", Science, 363, 1418-1423", @@ -275974,14 +277036,14 @@ "sim":1.0, "partner":"7udz" }, - { - "sim":1.0, - "partner":"7udy" - }, { "sim":0.9980000257, "partner":"7udw" }, + { + "sim":1.0, + "partner":"7udy" + }, { "sim":1.0, "partner":"7udx" @@ -276000,14 +277062,14 @@ ], "seq_max_sim_designed":{ "sim":43.0, - "partner":"6mct" + "partner":"6mq2" }, "seq_max_sim_natural":[ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"7udz" + "partner":"7udv" }, "struct_max_sim_natural":[ @@ -276071,80 +277133,80 @@ "de novo design" ], "keywords":[ - "evolution", - "poorly", - "chains", - "simulation", - "stringent", - "alone", - "conform", "membranes", - "proteins", - "membrane", - "entirely", - "proteome", - "steric", - "remain", + "designed", + "conform", "complementarity", - "stable", - "although", - "apolar", - "feature", + "redesign", + "shows", + "poorly", + "steric", + "role", + "hydrophobic", + "stringent", + "structural", + "prominent", + "destabilize", "variants", - "lipids", - "fold", - "sufficient", + "structurally", + "structures", + "feature", + "natural", "phospholamban", - "disruption", - "designed", + "apolar", + "side", "define", - "surprisingly", - "code", - "highly", - "emphasizing", - "understood", - "modestly", - "little", - "motif", - "folds", - "energetics", + "contribute", + "effect", + "recurs", + "assembly", + "synthetic", + "fold", "polar", - "stabilize", - "features", + "although", + "folding", + "code", "drive", - "structures", + "intended", "interactions", - "contributes", + "lipids", + "readily", "protein", - "synthetic", - "using", - "hydrophobic", + "contributes", + "emphasizing", + "membrane", "required", - "effect", - "natural", - "recurs", + "proteome", + "proteins", + "packing", + "little", + "achieved", "across", + "motif", + "stabilization", + "understood", + "energetics", + "modestly", + "underlying", + "entirely", + "native", + "remain", + "highly", + "sufficient", + "evolution", "precise", + "stable", + "disruption", + "stabilize", + "features", + "chains", "informatics", + "using", + "folds", + "simulation", + "alone", "stabilized", - "readily", - "structurally", - "native", - "redesign", - "underlying", - "assembly", - "intended", - "prominent", - "destabilize", - "shows", - "achieved", - "side", - "folding", - "contribute", - "packing", - "role", - "structural", - "stabilization" + "surprisingly" ], "release_date":"2019-04-03", "publication":"\"Packing of apolar side chains enables accurate design of highly stable membrane proteins\", Science, 363, 1418-1423", @@ -276284,88 +277346,88 @@ ], "subtitle":"Pl5, synthetic transmembrane domain variant of human phospholamban", "tags":[ - "transmembrane", - "phospholamban", "designed", + "pentamer", "de novo protein", "engineered", - "pentamer" + "transmembrane", + "phospholamban" ], "keywords":[ - "evolution", - "poorly", - "chains", - "simulation", - "stringent", - "alone", - "conform", "membranes", - "proteins", - "membrane", - "entirely", - "proteome", - "steric", - "remain", + "designed", + "conform", "complementarity", - "stable", - "although", - "apolar", - "feature", + "redesign", + "shows", + "poorly", + "steric", + "role", + "hydrophobic", + "stringent", + "structural", + "prominent", + "destabilize", "variants", - "lipids", - "fold", - "sufficient", + "structurally", + "structures", + "feature", + "natural", "phospholamban", - "disruption", - "designed", + "apolar", + "side", "define", - "surprisingly", - "code", - "highly", - "emphasizing", - "understood", - "modestly", - "little", - "motif", - "folds", - "energetics", + "contribute", + "effect", + "recurs", + "assembly", + "synthetic", + "fold", "polar", - "stabilize", - "features", + "although", + "folding", + "code", "drive", - "structures", + "intended", "interactions", - "contributes", + "lipids", + "readily", "protein", - "synthetic", - "using", - "hydrophobic", + "contributes", + "emphasizing", + "membrane", "required", - "effect", - "natural", - "recurs", + "proteome", + "proteins", + "packing", + "little", + "achieved", "across", + "motif", + "stabilization", + "understood", + "energetics", + "modestly", + "underlying", + "entirely", + "native", + "remain", + "highly", + "sufficient", + "evolution", "precise", + "stable", + "disruption", + "stabilize", + "features", + "chains", "informatics", + "using", + "folds", + "simulation", + "alone", "stabilized", - "readily", - "structurally", - "native", - "redesign", - "underlying", - "assembly", - "intended", - "prominent", - "destabilize", - "shows", - "achieved", - "side", - "folding", - "contribute", - "packing", - "role", - "structural", - "stabilization" + "surprisingly" ], "release_date":"2019-04-03", "publication":"\"Packing of apolar side chains enables accurate design of highly stable membrane proteins\", Science, 363, 1418-1423", @@ -276537,133 +277599,133 @@ "de novo protein" ], "keywords":[ - "galaxyzoo", - "work", - "craft", - "analysis", - "many", - "monomeric", - "part", - "possibilities", - "exception", - "improvement", - "player", - "challenge", - "acid", - "peptide", - "expressed", - "eterna", - "determined", - "sequences", - "online", - "discover", - "synthetic", - "adopt", - "structure", - "diversity", - "escherichia", - "creative", - "building", - "however", - "base", - "creativity", - "discrete", - "5", - "chain", - "proteins", - "models", - "challenges", - "presented", - "de", - "solutions", - "outstanding", "learn", + "genes", + "escherichia", + "adopt", + "unrelated", + "iterations", "hundred", + "outstanding", + "intrinsically", + "56", + "extended", + "acid", + "polypeptide", + "new", + "protein", + "improvement", + "contributes", + "5", "fully", - "3", - "occurring", - "folded", - "structures", - "naturally", - "natural", - "solution", - "foldit", - "representing", "annotation", - "projects", - "processing", - "game", + "novo", + "encoding", + "subsequent", + "foldit", + "creativity", + "stable", + "encoded", + "galaxyzoo", + "occurring", + "knowledge", "shows", + "however", "nearly", - "iterations", - "intrinsically", - "exploring", - "makes", - "data", - "considerable", - "amino", - "posed", - "subsequent", - "coli", - "extended", + "soluble", "rna", - "56", + "citizen", + "scientists", + "makes", + "players", + "folded", + "exploring", + "representing", + "20", + "proteins", + "part", + "creative", + "2", + "craft", + "success", + "possibilities", + "found", + "unprecedented", "four", + "online", "1", - "citizen", - "4", + "peptide", + "base", + "discrete", + "game", + "posed", + "science", + "task", "challenging", + "design", + "chain", + "work", + "natural", + "processing", + "different", + "representation", + "fold", + "diversity", "successful", - "harnessed", - "phylo", + "collection", + "implicit", + "build", + "amino", + "pairing", + "solution", "challenged", - "observed", - "design", - "task", - "polypeptide", + "coli", + "building", + "sequence", + "identical", "encode", - "contributes", - "rather", - "soluble", "present", + "exception", + "phylo", "explicit", - "sequence", - "representation", - "encoded", - "genes", - "scientists", - "collection", - "designs", - "skills", - "encoding", + "analysis", + "models", + "naturally", + "sequences", + "many", + "space", "one", - "build", - "eyewire", - "novo", - "stable", - "unprecedented", - "success", - "human", - "fold", - "proven", - "different", - "science", - "found", - "unrelated", - "problem", "evaluation", - "players", - "protein", - "2", - "identical", - "pairing", - "space", - "knowledge", - "implicit", - "scientific", + "rather", + "observed", + "structures", + "de", + "expressed", + "3", + "structure", + "synthetic", + "monomeric", + "challenges", + "solutions", + "discover", + "determined", + "4", + "projects", "silico", - "20", - "new" + "scientific", + "presented", + "considerable", + "player", + "skills", + "proven", + "eyewire", + "data", + "problem", + "human", + "eterna", + "harnessed", + "challenge", + "designs" ], "release_date":"2019-06-12", "publication":"\"De novo protein design by citizen scientists\", Nature, 570, 390-394", @@ -276707,7 +277769,7 @@ ], "seq_max_sim_designed":{ "sim":38.0, - "partner":"8y9c" + "partner":"8y9b" }, "seq_max_sim_natural":[ @@ -276837,133 +277899,133 @@ "de novo protein" ], "keywords":[ - "galaxyzoo", - "work", - "craft", - "analysis", - "many", - "monomeric", - "part", - "possibilities", - "exception", - "improvement", - "player", - "challenge", - "acid", - "peptide", - "expressed", - "eterna", - "determined", - "sequences", - "online", - "discover", - "synthetic", - "adopt", - "structure", - "diversity", - "escherichia", - "creative", - "building", - "however", - "base", - "creativity", - "discrete", - "5", - "chain", - "proteins", - "models", - "challenges", - "presented", - "de", - "solutions", - "outstanding", "learn", + "genes", + "escherichia", + "adopt", + "unrelated", + "iterations", "hundred", + "outstanding", + "intrinsically", + "56", + "extended", + "acid", + "polypeptide", + "new", + "protein", + "improvement", + "contributes", + "5", "fully", - "3", - "occurring", - "folded", - "structures", - "naturally", - "natural", - "solution", - "foldit", - "representing", "annotation", - "projects", - "processing", - "game", + "novo", + "encoding", + "subsequent", + "foldit", + "creativity", + "stable", + "encoded", + "galaxyzoo", + "occurring", + "knowledge", "shows", + "however", "nearly", - "iterations", - "intrinsically", - "exploring", - "makes", - "data", - "considerable", - "amino", - "posed", - "subsequent", - "coli", - "extended", + "soluble", "rna", - "56", + "citizen", + "scientists", + "makes", + "players", + "folded", + "exploring", + "representing", + "20", + "proteins", + "part", + "creative", + "2", + "craft", + "success", + "possibilities", + "found", + "unprecedented", "four", + "online", "1", - "citizen", - "4", + "peptide", + "base", + "discrete", + "game", + "posed", + "science", + "task", "challenging", + "design", + "chain", + "work", + "natural", + "processing", + "different", + "representation", + "fold", + "diversity", "successful", - "harnessed", - "phylo", + "collection", + "implicit", + "build", + "amino", + "pairing", + "solution", "challenged", - "observed", - "design", - "task", - "polypeptide", + "coli", + "building", + "sequence", + "identical", "encode", - "contributes", - "rather", - "soluble", "present", + "exception", + "phylo", "explicit", - "sequence", - "representation", - "encoded", - "genes", - "scientists", - "collection", - "designs", - "skills", - "encoding", + "analysis", + "models", + "naturally", + "sequences", + "many", + "space", "one", - "build", - "eyewire", - "novo", - "stable", - "unprecedented", - "success", - "human", - "fold", - "proven", - "different", - "science", - "found", - "unrelated", - "problem", "evaluation", - "players", - "protein", - "2", - "identical", - "pairing", - "space", - "knowledge", - "implicit", - "scientific", + "rather", + "observed", + "structures", + "de", + "expressed", + "3", + "structure", + "synthetic", + "monomeric", + "challenges", + "solutions", + "discover", + "determined", + "4", + "projects", "silico", - "20", - "new" + "scientific", + "presented", + "considerable", + "player", + "skills", + "proven", + "eyewire", + "data", + "problem", + "human", + "eterna", + "harnessed", + "challenge", + "designs" ], "release_date":"2019-06-12", "publication":"\"De novo protein design by citizen scientists\", Nature, 570, 390-394", @@ -277140,137 +278202,137 @@ ], "subtitle":"De novo designed protein foldit3", "tags":[ - "de no designed foldit foldit3", - "de novo protein" + "de novo protein", + "de no designed foldit foldit3" ], "keywords":[ - "galaxyzoo", - "work", - "craft", - "analysis", - "many", - "monomeric", - "part", - "possibilities", - "exception", - "improvement", - "player", - "challenge", - "acid", - "peptide", - "expressed", - "eterna", - "determined", - "sequences", - "online", - "discover", - "synthetic", - "adopt", - "structure", - "diversity", - "escherichia", - "creative", - "building", - "however", - "base", - "creativity", - "discrete", - "5", - "chain", - "proteins", - "models", - "challenges", - "presented", - "de", - "solutions", - "outstanding", "learn", + "genes", + "escherichia", + "adopt", + "unrelated", + "iterations", "hundred", + "outstanding", + "intrinsically", + "56", + "extended", + "acid", + "polypeptide", + "new", + "protein", + "improvement", + "contributes", + "5", "fully", - "3", - "occurring", - "folded", - "structures", - "naturally", - "natural", - "solution", - "foldit", - "representing", "annotation", - "projects", - "processing", - "game", + "novo", + "encoding", + "subsequent", + "foldit", + "creativity", + "stable", + "encoded", + "galaxyzoo", + "occurring", + "knowledge", "shows", + "however", "nearly", - "iterations", - "intrinsically", - "exploring", - "makes", - "data", - "considerable", - "amino", - "posed", - "subsequent", - "coli", - "extended", + "soluble", "rna", - "56", + "citizen", + "scientists", + "makes", + "players", + "folded", + "exploring", + "representing", + "20", + "proteins", + "part", + "creative", + "2", + "craft", + "success", + "possibilities", + "found", + "unprecedented", "four", + "online", "1", - "citizen", - "4", + "peptide", + "base", + "discrete", + "game", + "posed", + "science", + "task", "challenging", + "design", + "chain", + "work", + "natural", + "processing", + "different", + "representation", + "fold", + "diversity", "successful", - "harnessed", - "phylo", + "collection", + "implicit", + "build", + "amino", + "pairing", + "solution", "challenged", - "observed", - "design", - "task", - "polypeptide", + "coli", + "building", + "sequence", + "identical", "encode", - "contributes", - "rather", - "soluble", "present", + "exception", + "phylo", "explicit", - "sequence", - "representation", - "encoded", - "genes", - "scientists", - "collection", - "designs", - "skills", - "encoding", + "analysis", + "models", + "naturally", + "sequences", + "many", + "space", "one", - "build", - "eyewire", - "novo", - "stable", - "unprecedented", - "success", - "human", - "fold", - "proven", - "different", - "science", - "found", - "unrelated", - "problem", "evaluation", - "players", - "protein", - "2", - "identical", - "pairing", - "space", - "knowledge", - "implicit", - "scientific", + "rather", + "observed", + "structures", + "de", + "expressed", + "3", + "structure", + "synthetic", + "monomeric", + "challenges", + "solutions", + "discover", + "determined", + "4", + "projects", "silico", - "20", - "new" + "scientific", + "presented", + "considerable", + "player", + "skills", + "proven", + "eyewire", + "data", + "problem", + "human", + "eterna", + "harnessed", + "challenge", + "designs" ], "release_date":"2019-06-12", "publication":"\"De novo protein design by citizen scientists\", Nature, 570, 390-394", @@ -277448,77 +278510,77 @@ "helical bundle" ], "keywords":[ - "general", - "triggered", - "builds", - "demonstrate", + "membranes", + "cooperativity", + "designed", + "heterodimers", "environmentally", - "results", - "change", - "network", - "critical", - "proteins", - "undergo", + "conformation", + "deep", + "advances", "surrounding", - "membranes", - "endocytosed", + "mammalian", + "naturally", + "critical", + "design", "conformational", + "challenging", + "minimum", "steric", - "environmental", + "histidine", + "controlled", + "hydrophobic", + "number", + "electrostatic", "de", - "stable", "single", + "strength", + "endocytosed", + "biological", + "remains", + "lowered", + "disassembly", + "residues", + "repulsion", + "results", "although", - "changes", - "novo", "strategy", + "transition", + "precisely", + "interactions", + "protein", + "buried", + "network", + "protonated", + "become", + "function", + "preorganizing", + "ph", + "proteins", "response", - "cooperativity", - "designed", - "electrostatic", - "challenging", - "repulsion", - "controlled", - "number", - "disassembly", - "remains", - "residues", - "strength", + "lipid", + "changes", + "vitro", "programmed", - "become", - "lowered", - "precisely", - "advances", - "heterodimers", - "occurring", + "change", "ability", + "novo", + "general", + "networks", + "builds", + "upon", + "cells", + "demonstrate", + "homotrimers", "disrupt", - "vitro", - "design", - "preorganizing", - "lipid", - "naturally", - "protein", - "conformation", - "buried", "present", + "environmental", + "stable", + "triggered", "switches", "cooperative", - "hydrophobic", - "interactions", - "upon", - "mammalian", - "function", - "minimum", - "biological", - "networks", - "homotrimers", - "histidine", - "transition", - "ph", - "cells", - "deep", - "protonated" + "occurring", + "undergo" ], "release_date":"2019-05-08", "publication":"\"De novo design of tunable, pH-driven conformational changes\", Science, 364, 658-664", @@ -277739,77 +278801,77 @@ "helical bundle" ], "keywords":[ - "general", - "triggered", - "builds", - "demonstrate", + "membranes", + "cooperativity", + "designed", + "heterodimers", "environmentally", - "results", - "change", - "network", - "critical", - "proteins", - "undergo", + "conformation", + "deep", + "advances", "surrounding", - "membranes", - "endocytosed", + "mammalian", + "naturally", + "critical", + "design", "conformational", + "challenging", + "minimum", "steric", - "environmental", + "histidine", + "controlled", + "hydrophobic", + "number", + "electrostatic", "de", - "stable", "single", + "strength", + "endocytosed", + "biological", + "remains", + "lowered", + "disassembly", + "residues", + "repulsion", + "results", "although", - "changes", - "novo", "strategy", + "transition", + "precisely", + "interactions", + "protein", + "buried", + "network", + "protonated", + "become", + "function", + "preorganizing", + "ph", + "proteins", "response", - "cooperativity", - "designed", - "electrostatic", - "challenging", - "repulsion", - "controlled", - "number", - "disassembly", - "remains", - "residues", - "strength", + "lipid", + "changes", + "vitro", "programmed", - "become", - "lowered", - "precisely", - "advances", - "heterodimers", - "occurring", + "change", "ability", + "novo", + "general", + "networks", + "builds", + "upon", + "cells", + "demonstrate", + "homotrimers", "disrupt", - "vitro", - "design", - "preorganizing", - "lipid", - "naturally", - "protein", - "conformation", - "buried", "present", + "environmental", + "stable", + "triggered", "switches", "cooperative", - "hydrophobic", - "interactions", - "upon", - "mammalian", - "function", - "minimum", - "biological", - "networks", - "homotrimers", - "histidine", - "transition", - "ph", - "cells", - "deep", - "protonated" + "occurring", + "undergo" ], "release_date":"2019-05-08", "publication":"\"De novo design of tunable, pH-driven conformational changes\", Science, 364, 658-664", @@ -277878,11 +278940,11 @@ }, { "sim":55.0, - "partner":"6n9h" + "partner":"6naf" }, { "sim":55.0, - "partner":"6naf" + "partner":"6n9h" } ], "seq_thr_sim_natural":[ @@ -277997,85 +279059,85 @@ ], "subtitle":"Crystal structure of the designed protein dncr2\/danoprevir\/ns3a complex", "tags":[ - "de novo protein\/hydrolase\/inhibitor", - "danoprevir", "procisir", - "rosetta design", + "danoprevir", + "de novo protein\/hydrolase\/inhibitor", + "ns3a", "de novo protein-hydrolase-inhibitor complex", - "ns3a" + "rosetta design" ], "keywords":[ + "variable", + "researchers", + "engineering", + "program", + "engineered", + "translates", "responses", + "mammalian", + "signaling", + "however", + "show", + "methods", "diverse", - "modulation", - "control", "built", + "therapeutics", + "single", + "used", + "competing", + "multiple", "rac", - "outputs", - "confer", - "receiver", + "rho", + "based", + "suite", + "processes", + "titrate", + "enabled", + "apply", + "provide", + "optogenetic", + "diversity", "gtpases", - "proteins", + "tool", + "modulation", + "functions", + "therapies", + "behaviors", + "control", + "protein", "integrate", - "architecture", - "multiple", - "graded", - "chemical", - "program", "cell", - "rho", - "single", - "signaling", - "therapies", - "inputs", - "morphology", - "optogenetic", - "drug", - "including", - "tools", "activities", - "enable", - "programmed", - "apply", - "engineered", - "processes", - "used", - "approved", - "functions", - "engineer", - "provide", - "variable", - "methods", - "system", - "engineering", - "set", - "based", + "function", "controlling", - "show", + "drug", "proportional", - "reader", - "suite", - "versatile", - "therapeutics", - "protein", + "proteins", + "inputs", + "dimerization", + "programmed", + "cellular", + "tools", + "enable", + "architecture", + "receiver", "transcription", - "using", - "mammalian", + "outputs", "states", - "researchers", - "titrate", + "system", + "versatile", + "reader", + "morphology", + "confer", "variety", - "competing", - "function", - "behaviors", - "cellular", - "diversity", - "increase", - "enabled", - "however", - "translates", - "tool", - "dimerization" + "chemical", + "approved", + "graded", + "engineer", + "using", + "including", + "set", + "increase" ], "release_date":"2019-09-11", "publication":"\"Multi-input chemical control of protein dimerization for programming graded cellular responses\", Nat.Biotechnol., 37, 1209-1216", @@ -278260,81 +279322,81 @@ ], "subtitle":"De novo designed homo-trimeric amantadine-binding protein", "tags":[ - "trimer", - "de novo protein", "helical bundle", + "de novo protein", + "trimer", "amantadine-binding protein" ], "keywords":[ + "molecule", + "c", + "designed", + "highlight", + "calculations", + "symmetry", + "design", "localized", - "data", + "metal", + "structural", + "show", + "overcome", + "must", + "provides", + "used", + "de", + "experimental", + "inducible", + "approaches", + "yet", + "computationally", + "3", "ligand", "overall", - "amantadine", - "making", + "based", + "structure", + "rosetta", "challenges", - "reveals", - "larger", - "face", + "model", "neutron", - "must", - "exception", - "generate", - "de", - "novo", - "changes", - "molecule", - "metal", - "close", - "calculations", + "nmr", + "ion", + "protein", + "interactions", "exploration", - "rosetta", + "included", + "making", "drug", - "experimental", - "designed", - "validation", - "small", - "used", - "approaches", - "yet", - "binds", "symmetric", + "achieved", + "solution", + "regular", + "changes", + "binding", + "molecules", + "close", + "networks", + "undergoes", + "novo", + "upon", "site", - "3", "system", - "provides", + "small", + "reveals", "match", - "show", - "design", - "model", - "included", - "based", - "highlight", - "overcome", - "protein", - "interactions", - "regular", - "upon", + "larger", + "systems", "identical", - "nmr", - "symmetry", - "solution", - "c", - "structure", - "water", - "networks", - "computationally", + "amantadine", + "data", "monomer", - "computational", - "inducible", - "undergoes", - "achieved", - "molecules", - "systems", - "binding", - "structural", + "binds", + "exception", "create", - "ion" + "face", + "validation", + "computational", + "generate", + "water" ], "release_date":"2019-12-18", "publication":"\"De novo design of a homo-trimeric amantadine-binding protein\", Elife, 8", @@ -278502,81 +279564,81 @@ ], "subtitle":"De novo designed homo-trimeric amantadine-binding protein", "tags":[ - "trimer", - "de novo protein", "helical bundle", + "de novo protein", + "trimer", "amantadine-binding protein" ], "keywords":[ + "molecule", + "c", + "designed", + "highlight", + "calculations", + "symmetry", + "design", "localized", - "data", - "ligand", - "overall", - "amantadine", - "making", - "challenges", - "reveals", - "larger", - "face", - "neutron", + "metal", + "structural", + "show", + "overcome", "must", - "exception", - "generate", + "provides", + "used", "de", - "novo", - "changes", - "molecule", - "metal", - "close", - "calculations", - "exploration", - "rosetta", - "drug", "experimental", - "designed", - "validation", - "small", - "used", + "inducible", "approaches", "yet", - "binds", - "symmetric", - "site", + "computationally", "3", - "system", - "provides", - "match", - "show", - "design", - "model", - "included", + "ligand", + "overall", "based", - "highlight", - "overcome", + "structure", + "rosetta", + "challenges", + "model", + "neutron", + "nmr", + "ion", "protein", "interactions", - "regular", - "upon", - "identical", - "nmr", - "symmetry", + "exploration", + "included", + "making", + "drug", + "symmetric", + "achieved", "solution", - "c", - "structure", - "water", + "regular", + "changes", + "binding", + "molecules", + "close", "networks", - "computationally", - "monomer", - "computational", - "inducible", "undergoes", - "achieved", - "molecules", + "novo", + "upon", + "site", + "system", + "small", + "reveals", + "match", + "larger", "systems", - "binding", - "structural", + "identical", + "amantadine", + "data", + "monomer", + "binds", + "exception", "create", - "ion" + "face", + "validation", + "computational", + "generate", + "water" ], "release_date":"2019-12-18", "publication":"\"De novo design of a homo-trimeric amantadine-binding protein\", Elife, 8", @@ -278720,8 +279782,8 @@ ], "subtitle":"Crystal structure of a consensus pdz domain", "tags":[ - "pdz domain", "de novo protein", + "pdz domain", "consensus design" ], "keywords":[ @@ -278786,15 +279848,15 @@ }, { "sim":72.0, - "partner":"2m3m" + "partner":"2w4f" }, { "sim":72.0, - "partner":"2w4f" + "partner":"2oqs" }, { "sim":72.0, - "partner":"2oqs" + "partner":"2m3m" }, { "sim":72.0, @@ -278882,11 +279944,11 @@ }, { "sim":69.0, - "partner":"2awx" + "partner":"2aww" }, { "sim":69.0, - "partner":"2aww" + "partner":"2awx" }, { "sim":68.0, @@ -278974,11 +280036,11 @@ }, { "sim":64.0, - "partner":"2fn5" + "partner":"1gm1" }, { "sim":64.0, - "partner":"1gm1" + "partner":"2fn5" }, { "sim":64.0, @@ -279030,11 +280092,11 @@ }, { "sim":63.0, - "partner":"6qjn" + "partner":"6qjl" }, { "sim":63.0, - "partner":"6qjl" + "partner":"6qjn" }, { "sim":63.0, @@ -279102,15 +280164,15 @@ }, { "sim":62.0, - "partner":"1bfe" + "partner":"5hfd" }, { "sim":62.0, - "partner":"5hfd" + "partner":"5hfe" }, { "sim":62.0, - "partner":"5hfe" + "partner":"1bfe" }, { "sim":62.0, @@ -279252,10 +280314,6 @@ "sim":59.0, "partner":"2dc2" }, - { - "sim":59.0, - "partner":"4oep" - }, { "sim":59.0, "partner":"2h2b" @@ -279268,6 +280326,10 @@ "sim":59.0, "partner":"4oeo" }, + { + "sim":59.0, + "partner":"4oep" + }, { "sim":59.0, "partner":"2csj" @@ -279312,10 +280374,6 @@ "sim":57.0, "partner":"5wou" }, - { - "sim":57.0, - "partner":"4p2a" - }, { "sim":57.0, "partner":"5em9" @@ -279340,6 +280398,10 @@ "sim":57.0, "partner":"5elq" }, + { + "sim":57.0, + "partner":"4p2a" + }, { "sim":57.0, "partner":"2lc7" @@ -279398,11 +280460,11 @@ }, { "sim":56.0, - "partner":"3ch8" + "partner":"2qbw" }, { "sim":56.0, - "partner":"2qbw" + "partner":"3ch8" }, { "sim":55.0, @@ -279430,11 +280492,11 @@ }, { "sim":55.0, - "partner":"6q0m" + "partner":"6q0u" }, { "sim":55.0, - "partner":"6q0u" + "partner":"6q0m" }, { "sim":55.0, @@ -279492,14 +280554,6 @@ "sim":55.0, "partner":"2qt5" }, - { - "sim":54.0, - "partner":"4jok" - }, - { - "sim":54.0, - "partner":"4nmv" - }, { "sim":54.0, "partner":"4k72" @@ -279592,6 +280646,14 @@ "sim":54.0, "partner":"4joj" }, + { + "sim":54.0, + "partner":"4jok" + }, + { + "sim":54.0, + "partner":"4nmv" + }, { "sim":54.0, "partner":"5e1y" @@ -279722,11 +280784,11 @@ }, { "sim":51.0, - "partner":"2k20" + "partner":"2k1z" }, { "sim":51.0, - "partner":"2k1z" + "partner":"2k20" }, { "sim":51.0, @@ -279742,11 +280804,11 @@ }, { "sim":51.0, - "partner":"1uew" + "partner":"2edz" }, { "sim":51.0, - "partner":"2edz" + "partner":"1uew" }, { "sim":51.0, @@ -279798,15 +280860,15 @@ }, { "sim":50.0, - "partner":"2m0v" + "partner":"1uf1" }, { "sim":50.0, - "partner":"1uf1" + "partner":"2kjd" }, { "sim":50.0, - "partner":"2kjd" + "partner":"2m0v" }, { "sim":50.0, @@ -279967,133 +281029,133 @@ "de novo protein" ], "keywords":[ - "galaxyzoo", - "work", - "craft", - "analysis", - "many", - "monomeric", - "part", - "possibilities", - "exception", - "improvement", - "player", - "challenge", - "acid", - "peptide", - "expressed", - "eterna", - "determined", - "sequences", - "online", - "discover", - "synthetic", - "adopt", - "structure", - "diversity", - "escherichia", - "creative", - "building", - "however", - "base", - "creativity", - "discrete", - "5", - "chain", - "proteins", - "models", - "challenges", - "presented", - "de", - "solutions", - "outstanding", "learn", + "genes", + "escherichia", + "adopt", + "unrelated", + "iterations", "hundred", + "outstanding", + "intrinsically", + "56", + "extended", + "acid", + "polypeptide", + "new", + "protein", + "improvement", + "contributes", + "5", "fully", - "3", - "occurring", - "folded", - "structures", - "naturally", - "natural", - "solution", - "foldit", - "representing", "annotation", - "projects", - "processing", - "game", + "novo", + "encoding", + "subsequent", + "foldit", + "creativity", + "stable", + "encoded", + "galaxyzoo", + "occurring", + "knowledge", "shows", + "however", "nearly", - "iterations", - "intrinsically", - "exploring", - "makes", - "data", - "considerable", - "amino", - "posed", - "subsequent", - "coli", - "extended", + "soluble", "rna", - "56", + "citizen", + "scientists", + "makes", + "players", + "folded", + "exploring", + "representing", + "20", + "proteins", + "part", + "creative", + "2", + "craft", + "success", + "possibilities", + "found", + "unprecedented", "four", + "online", "1", - "citizen", - "4", + "peptide", + "base", + "discrete", + "game", + "posed", + "science", + "task", "challenging", + "design", + "chain", + "work", + "natural", + "processing", + "different", + "representation", + "fold", + "diversity", "successful", - "harnessed", - "phylo", + "collection", + "implicit", + "build", + "amino", + "pairing", + "solution", "challenged", - "observed", - "design", - "task", - "polypeptide", + "coli", + "building", + "sequence", + "identical", "encode", - "contributes", - "rather", - "soluble", "present", + "exception", + "phylo", "explicit", - "sequence", - "representation", - "encoded", - "genes", - "scientists", - "collection", - "designs", - "skills", - "encoding", + "analysis", + "models", + "naturally", + "sequences", + "many", + "space", "one", - "build", - "eyewire", - "novo", - "stable", - "unprecedented", - "success", - "human", - "fold", - "proven", - "different", - "science", - "found", - "unrelated", - "problem", "evaluation", - "players", - "protein", - "2", - "identical", - "pairing", - "space", - "knowledge", - "implicit", - "scientific", + "rather", + "observed", + "structures", + "de", + "expressed", + "3", + "structure", + "synthetic", + "monomeric", + "challenges", + "solutions", + "discover", + "determined", + "4", + "projects", "silico", - "20", - "new" + "scientific", + "presented", + "considerable", + "player", + "skills", + "proven", + "eyewire", + "data", + "problem", + "human", + "eterna", + "harnessed", + "challenge", + "designs" ], "release_date":"2019-06-12", "publication":"\"De novo protein design by citizen scientists\", Nature, 570, 390-394", @@ -280229,110 +281291,110 @@ "helix" ], "keywords":[ - "alexander", - "change", - "long", - "challenge", - "j", - "designed", - "nat", - "huang", - "methods", - "baker", - "chica", - "bistable", - "94", - "sequences", "acad", "adopt", - "structurally", - "stage", - "conformations", - "spectroscopic", - "proteins", - "viral", - "forms", - "height", - "environmental", - "reengineer", - "de", + "minimum", + "methods", + "single", "outstanding", - "boyken", - "\u00e5", - "response", - "remains", - "used", + "13", "bryan", - "106", + "2009", "short", - "nature", + "sci", + "protein", + "helical", + "changes", + "novo", + "forms", + "two", + "related", + "nat", + "either", + "deep", "occurring", - "dynamics", - "alter", - "structures", - "naturally", - "natural", + "creating", + "shows", + "conformational", + "alexander", + "divergent", "populates", - "function", - "minimum", - "fusion", - "either", + "biological", + "accessible", "transition", - "shows", - "biol", - "sci", - "2009", - "obtained", + "106", + "depending", + "sets", + "response", + "proteins", + "characterization", "proc", + "long", + "computational", + "bundle", + "switches", + "goto", + "obtained", + "spectroscopic", + "boyken", "identity", - "orban", + "critical", + "design", + "fusion", + "used", + "natural", + "height", + "different", + "fold", + "bistable", + "huang", + "chen", "conditions", - "2016", - "changes", + "viral", + "baker", + "states", + "plasticity", + "sequence", + "considerably", + "davey", + "poised", + "orban", + "crystallographic", + "measurement", + "dynamics", + "94", + "designed", + "naturally", + "sequences", + "sought", + "structurally", + "structures", + "de", + "remains", + "\u00e5", "shape", - "divergent", + "homotrimeric", + "chica", "closely", - "bundle", - "design", - "crystallographic", - "characterization", - "helical", - "considerably", - "states", - "switches", "nmr", - "measurement", - "sequence", + "state", + "nature", "2017", - "biological", - "goto", - "poised", + "function", + "2016", + "j", + "change", + "natl", + "alter", "537", - "13", - "depending", + "biol", + "conformations", + "environmental", + "challenge", "damry", - "chen", - "critical", - "accessible", - "conformational", - "novo", - "single", - "sets", - "fold", - "davey", - "different", - "two", - "state", - "creating", - "homotrimeric", - "sought", - "protein", - "computational", + "stage", "chem", - "deep", - "related", - "natl", - "plasticity" + "reengineer" ], "release_date":"2020-04-22", "publication":"\"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds\", Proc.Natl.Acad.Sci.USA, 117, 7208-7215", @@ -280385,11 +281447,11 @@ }, { "sim":155.0, - "partner":"6nxm" + "partner":"6ny8" }, { "sim":155.0, - "partner":"6ny8" + "partner":"6nxm" }, { "sim":154.0, @@ -280509,110 +281571,110 @@ "helix" ], "keywords":[ - "alexander", - "change", - "long", - "challenge", - "j", - "designed", - "nat", - "huang", - "methods", - "baker", - "chica", - "bistable", - "94", - "sequences", "acad", "adopt", - "structurally", - "stage", - "conformations", - "spectroscopic", - "proteins", - "viral", - "forms", - "height", - "environmental", - "reengineer", - "de", + "minimum", + "methods", + "single", "outstanding", - "boyken", - "\u00e5", - "response", - "remains", - "used", + "13", "bryan", - "106", + "2009", "short", - "nature", + "sci", + "protein", + "helical", + "changes", + "novo", + "forms", + "two", + "related", + "nat", + "either", + "deep", "occurring", - "dynamics", - "alter", - "structures", - "naturally", - "natural", + "creating", + "shows", + "conformational", + "alexander", + "divergent", "populates", - "function", - "minimum", - "fusion", - "either", + "biological", + "accessible", "transition", - "shows", - "biol", - "sci", - "2009", - "obtained", + "106", + "depending", + "sets", + "response", + "proteins", + "characterization", "proc", + "long", + "computational", + "bundle", + "switches", + "goto", + "obtained", + "spectroscopic", + "boyken", "identity", - "orban", + "critical", + "design", + "fusion", + "used", + "natural", + "height", + "different", + "fold", + "bistable", + "huang", + "chen", "conditions", - "2016", - "changes", + "viral", + "baker", + "states", + "plasticity", + "sequence", + "considerably", + "davey", + "poised", + "orban", + "crystallographic", + "measurement", + "dynamics", + "94", + "designed", + "naturally", + "sequences", + "sought", + "structurally", + "structures", + "de", + "remains", + "\u00e5", "shape", - "divergent", + "homotrimeric", + "chica", "closely", - "bundle", - "design", - "crystallographic", - "characterization", - "helical", - "considerably", - "states", - "switches", "nmr", - "measurement", - "sequence", + "state", + "nature", "2017", - "biological", - "goto", - "poised", + "function", + "2016", + "j", + "change", + "natl", + "alter", "537", - "13", - "depending", + "biol", + "conformations", + "environmental", + "challenge", "damry", - "chen", - "critical", - "accessible", - "conformational", - "novo", - "single", - "sets", - "fold", - "davey", - "different", - "two", - "state", - "creating", - "homotrimeric", - "sought", - "protein", - "computational", + "stage", "chem", - "deep", - "related", - "natl", - "plasticity" + "reengineer" ], "release_date":"2020-04-22", "publication":"\"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds\", Proc.Natl.Acad.Sci.USA, 117, 7208-7215", @@ -280789,110 +281851,110 @@ "helix" ], "keywords":[ - "alexander", - "change", - "long", - "challenge", - "j", - "designed", - "nat", - "huang", - "methods", - "baker", - "chica", - "bistable", - "94", - "sequences", "acad", "adopt", - "structurally", - "stage", - "conformations", - "spectroscopic", - "proteins", - "viral", - "forms", - "height", - "environmental", - "reengineer", - "de", + "minimum", + "methods", + "single", "outstanding", - "boyken", - "\u00e5", - "response", - "remains", - "used", + "13", "bryan", - "106", + "2009", "short", - "nature", + "sci", + "protein", + "helical", + "changes", + "novo", + "forms", + "two", + "related", + "nat", + "either", + "deep", "occurring", - "dynamics", - "alter", - "structures", - "naturally", - "natural", + "creating", + "shows", + "conformational", + "alexander", + "divergent", "populates", - "function", - "minimum", - "fusion", - "either", + "biological", + "accessible", "transition", - "shows", - "biol", - "sci", - "2009", - "obtained", + "106", + "depending", + "sets", + "response", + "proteins", + "characterization", "proc", + "long", + "computational", + "bundle", + "switches", + "goto", + "obtained", + "spectroscopic", + "boyken", "identity", - "orban", + "critical", + "design", + "fusion", + "used", + "natural", + "height", + "different", + "fold", + "bistable", + "huang", + "chen", "conditions", - "2016", - "changes", + "viral", + "baker", + "states", + "plasticity", + "sequence", + "considerably", + "davey", + "poised", + "orban", + "crystallographic", + "measurement", + "dynamics", + "94", + "designed", + "naturally", + "sequences", + "sought", + "structurally", + "structures", + "de", + "remains", + "\u00e5", "shape", - "divergent", + "homotrimeric", + "chica", "closely", - "bundle", - "design", - "crystallographic", - "characterization", - "helical", - "considerably", - "states", - "switches", "nmr", - "measurement", - "sequence", + "state", + "nature", "2017", - "biological", - "goto", - "poised", + "function", + "2016", + "j", + "change", + "natl", + "alter", "537", - "13", - "depending", + "biol", + "conformations", + "environmental", + "challenge", "damry", - "chen", - "critical", - "accessible", - "conformational", - "novo", - "single", - "sets", - "fold", - "davey", - "different", - "two", - "state", - "creating", - "homotrimeric", - "sought", - "protein", - "computational", + "stage", "chem", - "deep", - "related", - "natl", - "plasticity" + "reengineer" ], "release_date":"2020-04-22", "publication":"\"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds\", Proc.Natl.Acad.Sci.USA, 117, 7208-7215", @@ -281069,110 +282131,110 @@ "helix" ], "keywords":[ - "alexander", - "change", - "long", - "challenge", - "j", - "designed", - "nat", - "huang", - "methods", - "baker", - "chica", - "bistable", - "94", - "sequences", "acad", "adopt", - "structurally", - "stage", - "conformations", - "spectroscopic", - "proteins", - "viral", - "forms", - "height", - "environmental", - "reengineer", - "de", + "minimum", + "methods", + "single", "outstanding", - "boyken", - "\u00e5", - "response", - "remains", - "used", + "13", "bryan", - "106", + "2009", "short", - "nature", + "sci", + "protein", + "helical", + "changes", + "novo", + "forms", + "two", + "related", + "nat", + "either", + "deep", "occurring", - "dynamics", - "alter", - "structures", - "naturally", - "natural", + "creating", + "shows", + "conformational", + "alexander", + "divergent", "populates", - "function", - "minimum", - "fusion", - "either", + "biological", + "accessible", "transition", - "shows", - "biol", - "sci", - "2009", - "obtained", + "106", + "depending", + "sets", + "response", + "proteins", + "characterization", "proc", + "long", + "computational", + "bundle", + "switches", + "goto", + "obtained", + "spectroscopic", + "boyken", "identity", - "orban", + "critical", + "design", + "fusion", + "used", + "natural", + "height", + "different", + "fold", + "bistable", + "huang", + "chen", "conditions", - "2016", - "changes", + "viral", + "baker", + "states", + "plasticity", + "sequence", + "considerably", + "davey", + "poised", + "orban", + "crystallographic", + "measurement", + "dynamics", + "94", + "designed", + "naturally", + "sequences", + "sought", + "structurally", + "structures", + "de", + "remains", + "\u00e5", "shape", - "divergent", + "homotrimeric", + "chica", "closely", - "bundle", - "design", - "crystallographic", - "characterization", - "helical", - "considerably", - "states", - "switches", "nmr", - "measurement", - "sequence", + "state", + "nature", "2017", - "biological", - "goto", - "poised", + "function", + "2016", + "j", + "change", + "natl", + "alter", "537", - "13", - "depending", + "biol", + "conformations", + "environmental", + "challenge", "damry", - "chen", - "critical", - "accessible", - "conformational", - "novo", - "single", - "sets", - "fold", - "davey", - "different", - "two", - "state", - "creating", - "homotrimeric", - "sought", - "protein", - "computational", + "stage", "chem", - "deep", - "related", - "natl", - "plasticity" + "reengineer" ], "release_date":"2020-04-22", "publication":"\"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds\", Proc.Natl.Acad.Sci.USA, 117, 7208-7215", @@ -281225,11 +282287,11 @@ }, { "sim":152.0, - "partner":"6nxm" + "partner":"6ny8" }, { "sim":152.0, - "partner":"6ny8" + "partner":"6nxm" }, { "sim":151.0, @@ -281342,110 +282404,110 @@ "helix" ], "keywords":[ - "alexander", - "change", - "long", - "challenge", - "j", - "designed", - "nat", - "huang", - "methods", - "baker", - "chica", - "bistable", - "94", - "sequences", "acad", "adopt", - "structurally", - "stage", - "conformations", - "spectroscopic", - "proteins", - "viral", - "forms", - "height", - "environmental", - "reengineer", - "de", + "minimum", + "methods", + "single", "outstanding", - "boyken", - "\u00e5", - "response", - "remains", - "used", + "13", "bryan", - "106", + "2009", "short", - "nature", + "sci", + "protein", + "helical", + "changes", + "novo", + "forms", + "two", + "related", + "nat", + "either", + "deep", "occurring", - "dynamics", - "alter", - "structures", - "naturally", - "natural", + "creating", + "shows", + "conformational", + "alexander", + "divergent", "populates", - "function", - "minimum", - "fusion", - "either", + "biological", + "accessible", "transition", - "shows", - "biol", - "sci", - "2009", - "obtained", + "106", + "depending", + "sets", + "response", + "proteins", + "characterization", "proc", + "long", + "computational", + "bundle", + "switches", + "goto", + "obtained", + "spectroscopic", + "boyken", "identity", - "orban", + "critical", + "design", + "fusion", + "used", + "natural", + "height", + "different", + "fold", + "bistable", + "huang", + "chen", "conditions", - "2016", - "changes", + "viral", + "baker", + "states", + "plasticity", + "sequence", + "considerably", + "davey", + "poised", + "orban", + "crystallographic", + "measurement", + "dynamics", + "94", + "designed", + "naturally", + "sequences", + "sought", + "structurally", + "structures", + "de", + "remains", + "\u00e5", "shape", - "divergent", + "homotrimeric", + "chica", "closely", - "bundle", - "design", - "crystallographic", - "characterization", - "helical", - "considerably", - "states", - "switches", "nmr", - "measurement", - "sequence", + "state", + "nature", "2017", - "biological", - "goto", - "poised", + "function", + "2016", + "j", + "change", + "natl", + "alter", "537", - "13", - "depending", + "biol", + "conformations", + "environmental", + "challenge", "damry", - "chen", - "critical", - "accessible", - "conformational", - "novo", - "single", - "sets", - "fold", - "davey", - "different", - "two", - "state", - "creating", - "homotrimeric", - "sought", - "protein", - "computational", + "stage", "chem", - "deep", - "related", - "natl", - "plasticity" + "reengineer" ], "release_date":"2020-04-22", "publication":"\"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds\", Proc.Natl.Acad.Sci.USA, 117, 7208-7215", @@ -281502,11 +282564,11 @@ }, { "sim":153.0, - "partner":"6nxm" + "partner":"6ny8" }, { "sim":153.0, - "partner":"6ny8" + "partner":"6nxm" }, { "sim":153.0, @@ -281618,110 +282680,110 @@ "helix" ], "keywords":[ - "alexander", - "change", - "long", - "challenge", - "j", - "designed", - "nat", - "huang", - "methods", - "baker", - "chica", - "bistable", - "94", - "sequences", "acad", "adopt", - "structurally", - "stage", - "conformations", - "spectroscopic", - "proteins", - "viral", - "forms", - "height", - "environmental", - "reengineer", - "de", + "minimum", + "methods", + "single", "outstanding", - "boyken", - "\u00e5", - "response", - "remains", - "used", + "13", "bryan", - "106", + "2009", "short", - "nature", + "sci", + "protein", + "helical", + "changes", + "novo", + "forms", + "two", + "related", + "nat", + "either", + "deep", "occurring", - "dynamics", - "alter", - "structures", - "naturally", - "natural", + "creating", + "shows", + "conformational", + "alexander", + "divergent", "populates", - "function", - "minimum", - "fusion", - "either", + "biological", + "accessible", "transition", - "shows", - "biol", - "sci", - "2009", - "obtained", + "106", + "depending", + "sets", + "response", + "proteins", + "characterization", "proc", + "long", + "computational", + "bundle", + "switches", + "goto", + "obtained", + "spectroscopic", + "boyken", "identity", - "orban", + "critical", + "design", + "fusion", + "used", + "natural", + "height", + "different", + "fold", + "bistable", + "huang", + "chen", "conditions", - "2016", - "changes", + "viral", + "baker", + "states", + "plasticity", + "sequence", + "considerably", + "davey", + "poised", + "orban", + "crystallographic", + "measurement", + "dynamics", + "94", + "designed", + "naturally", + "sequences", + "sought", + "structurally", + "structures", + "de", + "remains", + "\u00e5", "shape", - "divergent", + "homotrimeric", + "chica", "closely", - "bundle", - "design", - "crystallographic", - "characterization", - "helical", - "considerably", - "states", - "switches", "nmr", - "measurement", - "sequence", + "state", + "nature", "2017", - "biological", - "goto", - "poised", + "function", + "2016", + "j", + "change", + "natl", + "alter", "537", - "13", - "depending", + "biol", + "conformations", + "environmental", + "challenge", "damry", - "chen", - "critical", - "accessible", - "conformational", - "novo", - "single", - "sets", - "fold", - "davey", - "different", - "two", - "state", - "creating", - "homotrimeric", - "sought", - "protein", - "computational", + "stage", "chem", - "deep", - "related", - "natl", - "plasticity" + "reengineer" ], "release_date":"2020-04-22", "publication":"\"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds\", Proc.Natl.Acad.Sci.USA, 117, 7208-7215", @@ -281762,11 +282824,11 @@ }, { "sim":160.0, - "partner":"6nxm" + "partner":"6ny8" }, { "sim":160.0, - "partner":"6ny8" + "partner":"6nxm" }, { "sim":160.0, @@ -281891,110 +282953,110 @@ "helix" ], "keywords":[ - "alexander", - "change", - "long", - "challenge", - "j", - "designed", - "nat", - "huang", - "methods", - "baker", - "chica", - "bistable", - "94", - "sequences", "acad", "adopt", - "structurally", - "stage", - "conformations", - "spectroscopic", - "proteins", - "viral", - "forms", - "height", - "environmental", - "reengineer", - "de", + "minimum", + "methods", + "single", "outstanding", - "boyken", - "\u00e5", - "response", - "remains", - "used", + "13", "bryan", - "106", + "2009", "short", - "nature", + "sci", + "protein", + "helical", + "changes", + "novo", + "forms", + "two", + "related", + "nat", + "either", + "deep", "occurring", - "dynamics", - "alter", - "structures", - "naturally", - "natural", + "creating", + "shows", + "conformational", + "alexander", + "divergent", "populates", - "function", - "minimum", - "fusion", - "either", + "biological", + "accessible", "transition", - "shows", - "biol", - "sci", - "2009", - "obtained", + "106", + "depending", + "sets", + "response", + "proteins", + "characterization", "proc", + "long", + "computational", + "bundle", + "switches", + "goto", + "obtained", + "spectroscopic", + "boyken", "identity", - "orban", + "critical", + "design", + "fusion", + "used", + "natural", + "height", + "different", + "fold", + "bistable", + "huang", + "chen", "conditions", - "2016", - "changes", + "viral", + "baker", + "states", + "plasticity", + "sequence", + "considerably", + "davey", + "poised", + "orban", + "crystallographic", + "measurement", + "dynamics", + "94", + "designed", + "naturally", + "sequences", + "sought", + "structurally", + "structures", + "de", + "remains", + "\u00e5", "shape", - "divergent", + "homotrimeric", + "chica", "closely", - "bundle", - "design", - "crystallographic", - "characterization", - "helical", - "considerably", - "states", - "switches", "nmr", - "measurement", - "sequence", + "state", + "nature", "2017", - "biological", - "goto", - "poised", + "function", + "2016", + "j", + "change", + "natl", + "alter", "537", - "13", - "depending", + "biol", + "conformations", + "environmental", + "challenge", "damry", - "chen", - "critical", - "accessible", - "conformational", - "novo", - "single", - "sets", - "fold", - "davey", - "different", - "two", - "state", - "creating", - "homotrimeric", - "sought", - "protein", - "computational", + "stage", "chem", - "deep", - "related", - "natl", - "plasticity" + "reengineer" ], "release_date":"2020-04-22", "publication":"\"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds\", Proc.Natl.Acad.Sci.USA, 117, 7208-7215", @@ -282035,11 +283097,11 @@ }, { "sim":161.0, - "partner":"6nxm" + "partner":"6ny8" }, { "sim":161.0, - "partner":"6ny8" + "partner":"6nxm" }, { "sim":160.0, @@ -282167,110 +283229,110 @@ "helix" ], "keywords":[ - "alexander", - "change", - "long", - "challenge", - "j", - "designed", - "nat", - "huang", - "methods", - "baker", - "chica", - "bistable", - "94", - "sequences", "acad", "adopt", - "structurally", - "stage", - "conformations", - "spectroscopic", - "proteins", - "viral", - "forms", - "height", - "environmental", - "reengineer", - "de", + "minimum", + "methods", + "single", "outstanding", - "boyken", - "\u00e5", - "response", - "remains", - "used", + "13", "bryan", - "106", + "2009", "short", - "nature", + "sci", + "protein", + "helical", + "changes", + "novo", + "forms", + "two", + "related", + "nat", + "either", + "deep", "occurring", - "dynamics", - "alter", - "structures", - "naturally", - "natural", + "creating", + "shows", + "conformational", + "alexander", + "divergent", "populates", - "function", - "minimum", - "fusion", - "either", + "biological", + "accessible", "transition", - "shows", - "biol", - "sci", - "2009", - "obtained", + "106", + "depending", + "sets", + "response", + "proteins", + "characterization", "proc", + "long", + "computational", + "bundle", + "switches", + "goto", + "obtained", + "spectroscopic", + "boyken", "identity", - "orban", + "critical", + "design", + "fusion", + "used", + "natural", + "height", + "different", + "fold", + "bistable", + "huang", + "chen", "conditions", - "2016", - "changes", + "viral", + "baker", + "states", + "plasticity", + "sequence", + "considerably", + "davey", + "poised", + "orban", + "crystallographic", + "measurement", + "dynamics", + "94", + "designed", + "naturally", + "sequences", + "sought", + "structurally", + "structures", + "de", + "remains", + "\u00e5", "shape", - "divergent", + "homotrimeric", + "chica", "closely", - "bundle", - "design", - "crystallographic", - "characterization", - "helical", - "considerably", - "states", - "switches", "nmr", - "measurement", - "sequence", + "state", + "nature", "2017", - "biological", - "goto", - "poised", + "function", + "2016", + "j", + "change", + "natl", + "alter", "537", - "13", - "depending", + "biol", + "conformations", + "environmental", + "challenge", "damry", - "chen", - "critical", - "accessible", - "conformational", - "novo", - "single", - "sets", - "fold", - "davey", - "different", - "two", - "state", - "creating", - "homotrimeric", - "sought", - "protein", - "computational", + "stage", "chem", - "deep", - "related", - "natl", - "plasticity" + "reengineer" ], "release_date":"2020-04-22", "publication":"\"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds\", Proc.Natl.Acad.Sci.USA, 117, 7208-7215", @@ -282303,11 +283365,11 @@ "seq_thr_sim_designed":[ { "sim":168.0, - "partner":"6nxm" + "partner":"6ny8" }, { "sim":168.0, - "partner":"6ny8" + "partner":"6nxm" }, { "sim":168.0, @@ -282323,11 +283385,11 @@ }, { "sim":158.0, - "partner":"6nyk" + "partner":"6nx2" }, { "sim":158.0, - "partner":"6nx2" + "partner":"6nyk" }, { "sim":155.0, @@ -282356,7 +283418,7 @@ ], "seq_max_sim_designed":{ "sim":168.0, - "partner":"6nxm" + "partner":"6ny8" }, "seq_max_sim_natural":[ @@ -282445,110 +283507,110 @@ "de novo protein" ], "keywords":[ - "alexander", - "change", - "long", - "challenge", - "j", - "designed", - "nat", - "huang", - "methods", - "baker", - "chica", - "bistable", - "94", - "sequences", "acad", "adopt", - "structurally", - "stage", - "conformations", - "spectroscopic", - "proteins", - "viral", - "forms", - "height", - "environmental", - "reengineer", - "de", + "minimum", + "methods", + "single", "outstanding", - "boyken", - "\u00e5", - "response", - "remains", - "used", + "13", "bryan", - "106", + "2009", "short", - "nature", + "sci", + "protein", + "helical", + "changes", + "novo", + "forms", + "two", + "related", + "nat", + "either", + "deep", "occurring", - "dynamics", - "alter", - "structures", - "naturally", - "natural", + "creating", + "shows", + "conformational", + "alexander", + "divergent", "populates", - "function", - "minimum", - "fusion", - "either", + "biological", + "accessible", "transition", - "shows", - "biol", - "sci", - "2009", - "obtained", + "106", + "depending", + "sets", + "response", + "proteins", + "characterization", "proc", + "long", + "computational", + "bundle", + "switches", + "goto", + "obtained", + "spectroscopic", + "boyken", "identity", - "orban", + "critical", + "design", + "fusion", + "used", + "natural", + "height", + "different", + "fold", + "bistable", + "huang", + "chen", "conditions", - "2016", - "changes", + "viral", + "baker", + "states", + "plasticity", + "sequence", + "considerably", + "davey", + "poised", + "orban", + "crystallographic", + "measurement", + "dynamics", + "94", + "designed", + "naturally", + "sequences", + "sought", + "structurally", + "structures", + "de", + "remains", + "\u00e5", "shape", - "divergent", + "homotrimeric", + "chica", "closely", - "bundle", - "design", - "crystallographic", - "characterization", - "helical", - "considerably", - "states", - "switches", "nmr", - "measurement", - "sequence", + "state", + "nature", "2017", - "biological", - "goto", - "poised", + "function", + "2016", + "j", + "change", + "natl", + "alter", "537", - "13", - "depending", + "biol", + "conformations", + "environmental", + "challenge", "damry", - "chen", - "critical", - "accessible", - "conformational", - "novo", - "single", - "sets", - "fold", - "davey", - "different", - "two", - "state", - "creating", - "homotrimeric", - "sought", - "protein", - "computational", + "stage", "chem", - "deep", - "related", - "natl", - "plasticity" + "reengineer" ], "release_date":"2020-04-22", "publication":"\"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds\", Proc.Natl.Acad.Sci.USA, 117, 7208-7215", @@ -282581,11 +283643,11 @@ "seq_thr_sim_designed":[ { "sim":175.0, - "partner":"6nxm" + "partner":"6ny8" }, { "sim":175.0, - "partner":"6ny8" + "partner":"6nxm" }, { "sim":168.0, @@ -282627,7 +283689,7 @@ ], "seq_max_sim_designed":{ "sim":175.0, - "partner":"6nxm" + "partner":"6ny8" }, "seq_max_sim_natural":[ @@ -282716,110 +283778,110 @@ "de novo protein" ], "keywords":[ - "alexander", - "change", - "long", - "challenge", - "j", - "designed", - "nat", - "huang", - "methods", - "baker", - "chica", - "bistable", - "94", - "sequences", "acad", "adopt", - "structurally", - "stage", - "conformations", - "spectroscopic", - "proteins", - "viral", - "forms", - "height", - "environmental", - "reengineer", - "de", + "minimum", + "methods", + "single", "outstanding", - "boyken", - "\u00e5", - "response", - "remains", - "used", + "13", "bryan", - "106", + "2009", "short", - "nature", + "sci", + "protein", + "helical", + "changes", + "novo", + "forms", + "two", + "related", + "nat", + "either", + "deep", "occurring", - "dynamics", - "alter", - "structures", - "naturally", - "natural", + "creating", + "shows", + "conformational", + "alexander", + "divergent", "populates", - "function", - "minimum", - "fusion", - "either", + "biological", + "accessible", "transition", - "shows", - "biol", - "sci", - "2009", - "obtained", + "106", + "depending", + "sets", + "response", + "proteins", + "characterization", "proc", + "long", + "computational", + "bundle", + "switches", + "goto", + "obtained", + "spectroscopic", + "boyken", "identity", - "orban", + "critical", + "design", + "fusion", + "used", + "natural", + "height", + "different", + "fold", + "bistable", + "huang", + "chen", "conditions", - "2016", - "changes", + "viral", + "baker", + "states", + "plasticity", + "sequence", + "considerably", + "davey", + "poised", + "orban", + "crystallographic", + "measurement", + "dynamics", + "94", + "designed", + "naturally", + "sequences", + "sought", + "structurally", + "structures", + "de", + "remains", + "\u00e5", "shape", - "divergent", + "homotrimeric", + "chica", "closely", - "bundle", - "design", - "crystallographic", - "characterization", - "helical", - "considerably", - "states", - "switches", "nmr", - "measurement", - "sequence", + "state", + "nature", "2017", - "biological", - "goto", - "poised", + "function", + "2016", + "j", + "change", + "natl", + "alter", "537", - "13", - "depending", + "biol", + "conformations", + "environmental", + "challenge", "damry", - "chen", - "critical", - "accessible", - "conformational", - "novo", - "single", - "sets", - "fold", - "davey", - "different", - "two", - "state", - "creating", - "homotrimeric", - "sought", - "protein", - "computational", + "stage", "chem", - "deep", - "related", - "natl", - "plasticity" + "reengineer" ], "release_date":"2020-04-22", "publication":"\"Computational design of closely related proteins that adopt two well-defined but structurally divergent folds\", Proc.Natl.Acad.Sci.USA, 117, 7208-7215", @@ -282872,11 +283934,11 @@ }, { "sim":163.0, - "partner":"6nxm" + "partner":"6ny8" }, { "sim":163.0, - "partner":"6ny8" + "partner":"6nxm" }, { "sim":162.0, @@ -283040,115 +284102,115 @@ ], "subtitle":"Crystal structure of a de novo designed octameric helical-bundle protein", "tags":[ + "helical bundle", "computational design", "pore", "de novo protein", - "octamer", - "helical bundle" + "octamer" ], "keywords":[ - "concentric", - "opens", - "fluorophores", - "matches", - "channels", - "ions", - "challenge", - "door", - "expressed", - "roles", - "crystal", - "alexa", - "fluor", + "biotechnological", + "biotinylated", + "488", + "key", "show", - "synthetic", - "pores", - "passage", - "structure", - "structurally", - "sequencing", - "however", - "modification", - "proteins", - "membrane", - "models", - "dna", - "enables", - "de", "outstanding", - "produce", - "amphiphilic", - "rings", + "functionally", "pore", - "processes", - "resulting", - "remains", - "liposomes", + "roles", + "model", + "protein", + "insect", "vitro", - "occurring", - "ability", + "across", + "microscopy", + "novo", + "cells", "match", + "forms", + "amphiphilic", + "two", + "variety", + "applications", + "recent", + "crystal", + "stable", + "door", + "using", + "occurring", + "monodisperse", "enough", - "structures", - "naturally", - "biotechnological", - "potassium", - "biotinylated", - "transmembrane", - "form", - "functionally", - "designer", - "considerable", - "entrance", + "enables", + "however", + "formed", + "interest", + "creation", + "dna", + "biological", + "specific", "incorporated", + "matches", + "entrance", + "conducting", + "proteins", "large", - "chemical", - "report", + "capable", + "ions", "blocked", + "alexa", + "found", + "chemical", + "electrophysiology", + "computational", "1", - "redesigning", - "interest", - "conducting", - "closely", - "synthesis", - "specific", + "concentric", "advances", - "488", - "insect", "design", - "model", - "using", - "applications", - "nanopore", - "selectively", - "across", - "recent", - "high", - "biological", - "key", - "cells", "sodium", - "ion", - "fundamental", - "monodisperse", - "novo", - "stable", - "wide", + "produce", + "processes", + "nanopore", + "synthesis", "experiments", + "selectivity", + "wide", + "liposomes", + "ability", + "sequencing", + "fluor", + "designer", + "selectively", + "channels", "peptides", + "potassium", + "pores", + "fundamental", + "form", + "fluorophores", + "models", + "naturally", + "modification", + "transmembrane", + "opens", + "structurally", + "structures", + "de", + "expressed", + "remains", + "structure", + "synthetic", + "report", + "resulting", + "closely", + "ion", + "membrane", + "redesigning", "enable", - "capable", - "found", - "selectivity", - "two", - "creation", - "protein", - "microscopy", - "electrophysiology", - "variety", - "computational", - "formed", - "forms" + "passage", + "considerable", + "high", + "rings", + "challenge" ], "release_date":"2020-03-18", "publication":"\"Computational design of transmembrane pores\", Nature, 585, 129-134", @@ -283273,86 +284335,86 @@ ], "subtitle":"Cross-alpha amyloid-like structure alphaama", "tags":[ - "coiled-coil", - "fibril", + "de novo design", "de novo protein", - "alpha-amyloid", - "de novo design" + "fibril", + "coiled-coil", + "alpha-amyloid" ], "keywords":[ - "spacing", - "versions", - "composed", - "running", - "fibril", + "spiraling", + "designed", + "form", + "superhelical", + "leucine", + "dimers", + "fluorescently", "toxic", - "predetermined", - "long", + "mammalian", + "polymer", + "adopt", "critical", - "170", - "assemblies", - "resulted", + "structural", + "vivo", + "planar", + "running", + "resemble", + "observed", + "structures", + "spacing", "ranging", - "\u00e5", "apolar", - "crystallographically", - "peptide", - "fibrils", - "200", - "peptides", - "designed", - "spiraling", - "twisted", + "different", + "\u00e5", + "amyloids", + "assembly", + "residues", + "structure", + "appeared", + "markedly", "rearrangement", "tagged", + "residue", + "puncta", + "170", + "recently", + "recover", + "protein", + "useful", + "axis", + "200", + "helical", "kinetics", + "packing", + "fibrils", + "solution", "pitches", - "small", - "residues", - "different", - "polymer", - "proposed", - "useful", + "crystallographically", + "resulted", + "photobleaching", + "cells", "directing", + "versions", + "small", + "peptides", + "composed", "potentially", - "characterize", - "photobleaching", - "dimers", - "crystal", - "leucine", + "fibril", "folds", - "amyloids", - "assemble", - "observed", - "fluorescently", - "helical", - "structures", - "superhelical", - "perpendicular", - "residue", - "adopt", "converted", - "puncta", - "mammalian", - "protein", - "stabilities", - "markedly", - "solution", - "structure", - "assembly", + "crystal", + "perpendicular", + "predetermined", + "assemble", + "assemblies", + "long", + "proposed", + "twisted", "stabilized", - "recently", + "characterize", + "peptide", "could", - "vivo", - "form", - "resemble", - "recover", - "axis", - "cells", - "appeared", - "packing", - "structural", - "planar" + "stabilities" ], "release_date":"2019-03-13", "publication":"\"Designed peptides that assemble into cross-alpha amyloid-like structures\", Nat. Chem. Biol., 14, 870-875", @@ -283419,14 +284481,14 @@ ], "seq_max_sim_designed":{ "sim":48.0, - "partner":"6c4z" + "partner":"6c50" }, "seq_max_sim_natural":[ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"6c51" + "partner":"6c4y" }, "struct_max_sim_natural":[ @@ -283540,11 +284602,11 @@ ], "subtitle":"Structure of ef1p2_mfap2b bound to dfhbi", "tags":[ - "computational", - "de novo protein", "ligand binder", - "ef-motif", "rossetta", + "de novo protein", + "ef-motif", + "computational", "beta barrel" ], "keywords":[ @@ -283673,41 +284735,41 @@ ], "subtitle":"Controlling the self-assembly of synthetic metal-coordinating coiled-coil peptides: orthorhombic lattice from a trimeric coiled coil", "tags":[ + "de novo protein", "supramolecular assembly", - "metal coordination framework", - "de novo protein" + "metal coordination framework" ], "keywords":[ "supramolecular", - "reported", - "control", - "serendipitously", "chemistry", - "coordination", - "drives", - "rational", + "crystalline", "metal", - "class", - "morphology", - "peptide", - "peptides", - "apply", - "materials", - "motif", - "blocks", - "versatile", "probe", - "exert", - "structure", - "assembly", "insights", - "combination", + "formed", + "rational", + "assembly", + "discovered", + "apply", + "structure", "recently", - "crystalline", - "building", + "control", + "serendipitously", + "exert", + "blocks", + "class", "binding", - "formed", - "discovered" + "motif", + "drives", + "coordination", + "building", + "reported", + "versatile", + "peptides", + "morphology", + "materials", + "combination", + "peptide" ], "release_date":"2020-02-19", "publication":"\"Understanding and controlling the metal-directed assembly of terpyridine-functionalized coiled-coil peptides\", Chem.Commun.(Camb.), 55, 7752-7755", @@ -283813,41 +284875,41 @@ ], "subtitle":"Controlling the self-assembly of synthetic metal-coordinating coiled-coil peptides: hexagonal lattice from a trimeric coiled coil", "tags":[ + "de novo protein", "supramolecular assembly", - "metal coordination framework", - "de novo protein" + "metal coordination framework" ], "keywords":[ "supramolecular", - "reported", - "control", - "serendipitously", "chemistry", - "coordination", - "drives", - "rational", + "crystalline", "metal", - "class", - "morphology", - "peptide", - "peptides", - "apply", - "materials", - "motif", - "blocks", - "versatile", "probe", - "exert", - "structure", - "assembly", "insights", - "combination", + "formed", + "rational", + "assembly", + "discovered", + "apply", + "structure", "recently", - "crystalline", - "building", + "control", + "serendipitously", + "exert", + "blocks", + "class", "binding", - "formed", - "discovered" + "motif", + "drives", + "coordination", + "building", + "reported", + "versatile", + "peptides", + "morphology", + "materials", + "combination", + "peptide" ], "release_date":"2020-03-25", "publication":"\"Understanding and controlling the metal-directed assembly of terpyridine-functionalized coiled-coil peptides\", Chem.Commun.(Camb.), 55, 7752-7755", @@ -283970,86 +285032,86 @@ "helix" ], "keywords":[ - "confirm", + "engineering", + "molecular", + "role", + "hydrophobic", + "hyperstable", + "show", + "presence", + "substitutions", + "surprising", + "within", "results", + "new", + "residue", + "lys18", + "positions", + "stabilization", + "pair", + "thermodynamic", + "b", + "exquisite", + "subsequent", + "depends", + "confirm", + "crystal", + "possibility", + "simulations", + "donor", + "favorably", + "bundles", + "consider", + "nearby", + "carefully", "stabilizing", - "possibilities", - "character", - "suggest", - "still", - "substitutions", + "involving", + "purposes", + "relative", + "residues", + "helix", + "primarily", + "depending", "interact", - "smaller", - "nearby", - "crystal", - "show", - "interactions", + "large", + "suggest", + "glu10", + "possibilities", + "extent", + "suggesting", + "facilitate", + "bundle", "c", - "surprising", + "highlight", + "need", + "identity", + "proximity", + "still", + "experiments", + "complexity", + "f", + "14", + "nonpolar", + "character", + "lys7", "interaction", - "synergistic", "allows", - "consider", - "suggesting", - "lys7", - "presence", - "carefully", - "highlight", + "associated", "dynamics", + "directly", "trimeric", + "indicate", "structures", - "14", - "positions", - "complexity", - "glu10", - "lys18", - "role", - "facilitate", - "need", - "primarily", + "important", + "among", + "interactions", "impact", "plays", - "molecular", - "directly", - "involving", - "identity", - "associated", - "large", - "subsequent", - "depends", - "bundles", - "extent", - "favorably", - "thermodynamic", + "synergistic", "emphasizing", - "among", "4", - "simulations", - "exquisite", - "engineering", - "bundle", - "donor", - "hydrophobic", - "proximity", - "indicate", - "important", - "stabilization", - "depending", - "nonpolar", - "possibility", - "experiments", - "residues", - "f", - "significant", - "b", - "residue", - "purposes", - "helix", - "hyperstable", - "within", - "relative", - "pair", - "new" + "smaller", + "significant" ], "release_date":"2020-04-29", "publication":"\"Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle\", Biochemistry, 59, 1672-1679", @@ -284086,11 +285148,11 @@ }, { "sim":61.0, - "partner":"6ov9" + "partner":"6osd" }, { "sim":61.0, - "partner":"6osd" + "partner":"6ov9" }, { "sim":59.0, @@ -284102,11 +285164,11 @@ }, { "sim":58.0, - "partner":"6v58" + "partner":"6ovv" }, { "sim":58.0, - "partner":"6ovv" + "partner":"6v57" }, { "sim":58.0, @@ -284114,27 +285176,27 @@ }, { "sim":58.0, - "partner":"6v57" + "partner":"6q1w" }, { "sim":58.0, - "partner":"6q1w" + "partner":"6v58" }, { "sim":57.0, - "partner":"6u47" + "partner":"6q22" }, { "sim":57.0, - "partner":"6q22" + "partner":"6u47" }, { "sim":56.0, - "partner":"6v5j" + "partner":"6v5g" }, { "sim":56.0, - "partner":"6v5g" + "partner":"6v5j" }, { "sim":55.0, @@ -284300,86 +285362,86 @@ "helix" ], "keywords":[ - "confirm", + "engineering", + "molecular", + "role", + "hydrophobic", + "hyperstable", + "show", + "presence", + "substitutions", + "surprising", + "within", "results", + "new", + "residue", + "lys18", + "positions", + "stabilization", + "pair", + "thermodynamic", + "b", + "exquisite", + "subsequent", + "depends", + "confirm", + "crystal", + "possibility", + "simulations", + "donor", + "favorably", + "bundles", + "consider", + "nearby", + "carefully", "stabilizing", - "possibilities", - "character", - "suggest", - "still", - "substitutions", + "involving", + "purposes", + "relative", + "residues", + "helix", + "primarily", + "depending", "interact", - "smaller", - "nearby", - "crystal", - "show", - "interactions", + "large", + "suggest", + "glu10", + "possibilities", + "extent", + "suggesting", + "facilitate", + "bundle", "c", - "surprising", + "highlight", + "need", + "identity", + "proximity", + "still", + "experiments", + "complexity", + "f", + "14", + "nonpolar", + "character", + "lys7", "interaction", - "synergistic", "allows", - "consider", - "suggesting", - "lys7", - "presence", - "carefully", - "highlight", + "associated", "dynamics", + "directly", "trimeric", + "indicate", "structures", - "14", - "positions", - "complexity", - "glu10", - "lys18", - "role", - "facilitate", - "need", - "primarily", + "important", + "among", + "interactions", "impact", "plays", - "molecular", - "directly", - "involving", - "identity", - "associated", - "large", - "subsequent", - "depends", - "bundles", - "extent", - "favorably", - "thermodynamic", + "synergistic", "emphasizing", - "among", "4", - "simulations", - "exquisite", - "engineering", - "bundle", - "donor", - "hydrophobic", - "proximity", - "indicate", - "important", - "stabilization", - "depending", - "nonpolar", - "possibility", - "experiments", - "residues", - "f", - "significant", - "b", - "residue", - "purposes", - "helix", - "hyperstable", - "within", - "relative", - "pair", - "new" + "smaller", + "significant" ], "release_date":"2020-04-29", "publication":"\"Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle\", Biochemistry, 59, 1672-1679", @@ -284428,11 +285490,11 @@ }, { "sim":62.0, - "partner":"6v58" + "partner":"6ovv" }, { "sim":62.0, - "partner":"6ovv" + "partner":"6v57" }, { "sim":62.0, @@ -284440,11 +285502,11 @@ }, { "sim":62.0, - "partner":"6v57" + "partner":"6q1w" }, { "sim":62.0, - "partner":"6q1w" + "partner":"6v58" }, { "sim":61.0, @@ -284452,19 +285514,19 @@ }, { "sim":61.0, - "partner":"6u47" + "partner":"6q22" }, { "sim":61.0, - "partner":"6q22" + "partner":"6u47" }, { "sim":60.0, - "partner":"6v5j" + "partner":"6v5g" }, { "sim":60.0, - "partner":"6v5g" + "partner":"6v5j" }, { "sim":59.0, @@ -284607,86 +285669,86 @@ "helix" ], "keywords":[ - "confirm", + "engineering", + "molecular", + "role", + "hydrophobic", + "hyperstable", + "show", + "presence", + "substitutions", + "surprising", + "within", "results", + "new", + "residue", + "lys18", + "positions", + "stabilization", + "pair", + "thermodynamic", + "b", + "exquisite", + "subsequent", + "depends", + "confirm", + "crystal", + "possibility", + "simulations", + "donor", + "favorably", + "bundles", + "consider", + "nearby", + "carefully", "stabilizing", - "possibilities", - "character", - "suggest", - "still", - "substitutions", + "involving", + "purposes", + "relative", + "residues", + "helix", + "primarily", + "depending", "interact", - "smaller", - "nearby", - "crystal", - "show", - "interactions", + "large", + "suggest", + "glu10", + "possibilities", + "extent", + "suggesting", + "facilitate", + "bundle", "c", - "surprising", + "highlight", + "need", + "identity", + "proximity", + "still", + "experiments", + "complexity", + "f", + "14", + "nonpolar", + "character", + "lys7", "interaction", - "synergistic", "allows", - "consider", - "suggesting", - "lys7", - "presence", - "carefully", - "highlight", + "associated", "dynamics", + "directly", "trimeric", + "indicate", "structures", - "14", - "positions", - "complexity", - "glu10", - "lys18", - "role", - "facilitate", - "need", - "primarily", + "important", + "among", + "interactions", "impact", "plays", - "molecular", - "directly", - "involving", - "identity", - "associated", - "large", - "subsequent", - "depends", - "bundles", - "extent", - "favorably", - "thermodynamic", + "synergistic", "emphasizing", - "among", "4", - "simulations", - "exquisite", - "engineering", - "bundle", - "donor", - "hydrophobic", - "proximity", - "indicate", - "important", - "stabilization", - "depending", - "nonpolar", - "possibility", - "experiments", - "residues", - "f", - "significant", - "b", - "residue", - "purposes", - "helix", - "hyperstable", - "within", - "relative", - "pair", - "new" + "smaller", + "significant" ], "release_date":"2020-04-29", "publication":"\"Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle\", Biochemistry, 59, 1672-1679", @@ -284735,11 +285797,11 @@ }, { "sim":62.0, - "partner":"6v58" + "partner":"6ovv" }, { "sim":62.0, - "partner":"6ovv" + "partner":"6v57" }, { "sim":62.0, @@ -284747,11 +285809,11 @@ }, { "sim":62.0, - "partner":"6v57" + "partner":"6q1w" }, { "sim":62.0, - "partner":"6q1w" + "partner":"6v58" }, { "sim":61.0, @@ -284759,19 +285821,19 @@ }, { "sim":61.0, - "partner":"6u47" + "partner":"6q22" }, { "sim":61.0, - "partner":"6q22" + "partner":"6u47" }, { "sim":60.0, - "partner":"6v5j" + "partner":"6v5g" }, { "sim":60.0, - "partner":"6v5g" + "partner":"6v5j" }, { "sim":59.0, @@ -284917,86 +285979,86 @@ "helix" ], "keywords":[ - "confirm", + "engineering", + "molecular", + "role", + "hydrophobic", + "hyperstable", + "show", + "presence", + "substitutions", + "surprising", + "within", "results", + "new", + "residue", + "lys18", + "positions", + "stabilization", + "pair", + "thermodynamic", + "b", + "exquisite", + "subsequent", + "depends", + "confirm", + "crystal", + "possibility", + "simulations", + "donor", + "favorably", + "bundles", + "consider", + "nearby", + "carefully", "stabilizing", - "possibilities", - "character", - "suggest", - "still", - "substitutions", + "involving", + "purposes", + "relative", + "residues", + "helix", + "primarily", + "depending", "interact", - "smaller", - "nearby", - "crystal", - "show", - "interactions", + "large", + "suggest", + "glu10", + "possibilities", + "extent", + "suggesting", + "facilitate", + "bundle", "c", - "surprising", + "highlight", + "need", + "identity", + "proximity", + "still", + "experiments", + "complexity", + "f", + "14", + "nonpolar", + "character", + "lys7", "interaction", - "synergistic", "allows", - "consider", - "suggesting", - "lys7", - "presence", - "carefully", - "highlight", + "associated", "dynamics", + "directly", "trimeric", + "indicate", "structures", - "14", - "positions", - "complexity", - "glu10", - "lys18", - "role", - "facilitate", - "need", - "primarily", + "important", + "among", + "interactions", "impact", "plays", - "molecular", - "directly", - "involving", - "identity", - "associated", - "large", - "subsequent", - "depends", - "bundles", - "extent", - "favorably", - "thermodynamic", + "synergistic", "emphasizing", - "among", "4", - "simulations", - "exquisite", - "engineering", - "bundle", - "donor", - "hydrophobic", - "proximity", - "indicate", - "important", - "stabilization", - "depending", - "nonpolar", - "possibility", - "experiments", - "residues", - "f", - "significant", - "b", - "residue", - "purposes", - "helix", - "hyperstable", - "within", - "relative", - "pair", - "new" + "smaller", + "significant" ], "release_date":"2020-04-29", "publication":"\"Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle\", Biochemistry, 59, 1672-1679", @@ -285155,86 +286217,86 @@ "helix" ], "keywords":[ - "confirm", + "engineering", + "molecular", + "role", + "hydrophobic", + "hyperstable", + "show", + "presence", + "substitutions", + "surprising", + "within", "results", + "new", + "residue", + "lys18", + "positions", + "stabilization", + "pair", + "thermodynamic", + "b", + "exquisite", + "subsequent", + "depends", + "confirm", + "crystal", + "possibility", + "simulations", + "donor", + "favorably", + "bundles", + "consider", + "nearby", + "carefully", "stabilizing", - "possibilities", - "character", - "suggest", - "still", - "substitutions", + "involving", + "purposes", + "relative", + "residues", + "helix", + "primarily", + "depending", "interact", - "smaller", - "nearby", - "crystal", - "show", - "interactions", + "large", + "suggest", + "glu10", + "possibilities", + "extent", + "suggesting", + "facilitate", + "bundle", "c", - "surprising", + "highlight", + "need", + "identity", + "proximity", + "still", + "experiments", + "complexity", + "f", + "14", + "nonpolar", + "character", + "lys7", "interaction", - "synergistic", "allows", - "consider", - "suggesting", - "lys7", - "presence", - "carefully", - "highlight", + "associated", "dynamics", + "directly", "trimeric", + "indicate", "structures", - "14", - "positions", - "complexity", - "glu10", - "lys18", - "role", - "facilitate", - "need", - "primarily", + "important", + "among", + "interactions", "impact", "plays", - "molecular", - "directly", - "involving", - "identity", - "associated", - "large", - "subsequent", - "depends", - "bundles", - "extent", - "favorably", - "thermodynamic", + "synergistic", "emphasizing", - "among", "4", - "simulations", - "exquisite", - "engineering", - "bundle", - "donor", - "hydrophobic", - "proximity", - "indicate", - "important", - "stabilization", - "depending", - "nonpolar", - "possibility", - "experiments", - "residues", - "f", - "significant", - "b", - "residue", - "purposes", - "helix", - "hyperstable", - "within", - "relative", - "pair", - "new" + "smaller", + "significant" ], "release_date":"2020-04-29", "publication":"\"Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle\", Biochemistry, 59, 1672-1679", @@ -285267,11 +286329,11 @@ "seq_thr_sim_designed":[ { "sim":65.0, - "partner":"6ov9" + "partner":"6osd" }, { "sim":65.0, - "partner":"6osd" + "partner":"6ov9" }, { "sim":64.0, @@ -285283,11 +286345,11 @@ }, { "sim":62.0, - "partner":"6v58" + "partner":"6ovv" }, { "sim":62.0, - "partner":"6ovv" + "partner":"6v57" }, { "sim":62.0, @@ -285295,11 +286357,11 @@ }, { "sim":62.0, - "partner":"6v57" + "partner":"6q1w" }, { "sim":62.0, - "partner":"6q1w" + "partner":"6v58" }, { "sim":61.0, @@ -285307,19 +286369,19 @@ }, { "sim":61.0, - "partner":"6u47" + "partner":"6q22" }, { "sim":61.0, - "partner":"6q22" + "partner":"6u47" }, { "sim":60.0, - "partner":"6v5j" + "partner":"6v5g" }, { "sim":60.0, - "partner":"6v5g" + "partner":"6v5j" }, { "sim":59.0, @@ -285412,7 +286474,7 @@ ], "seq_max_sim_designed":{ "sim":65.0, - "partner":"6ov9" + "partner":"6osd" }, "seq_max_sim_natural":[ @@ -285485,86 +286547,86 @@ "helix" ], "keywords":[ - "confirm", + "engineering", + "molecular", + "role", + "hydrophobic", + "hyperstable", + "show", + "presence", + "substitutions", + "surprising", + "within", "results", + "new", + "residue", + "lys18", + "positions", + "stabilization", + "pair", + "thermodynamic", + "b", + "exquisite", + "subsequent", + "depends", + "confirm", + "crystal", + "possibility", + "simulations", + "donor", + "favorably", + "bundles", + "consider", + "nearby", + "carefully", "stabilizing", - "possibilities", - "character", - "suggest", - "still", - "substitutions", + "involving", + "purposes", + "relative", + "residues", + "helix", + "primarily", + "depending", "interact", - "smaller", - "nearby", - "crystal", - "show", - "interactions", + "large", + "suggest", + "glu10", + "possibilities", + "extent", + "suggesting", + "facilitate", + "bundle", "c", - "surprising", + "highlight", + "need", + "identity", + "proximity", + "still", + "experiments", + "complexity", + "f", + "14", + "nonpolar", + "character", + "lys7", "interaction", - "synergistic", "allows", - "consider", - "suggesting", - "lys7", - "presence", - "carefully", - "highlight", + "associated", "dynamics", + "directly", "trimeric", + "indicate", "structures", - "14", - "positions", - "complexity", - "glu10", - "lys18", - "role", - "facilitate", - "need", - "primarily", + "important", + "among", + "interactions", "impact", "plays", - "molecular", - "directly", - "involving", - "identity", - "associated", - "large", - "subsequent", - "depends", - "bundles", - "extent", - "favorably", - "thermodynamic", + "synergistic", "emphasizing", - "among", "4", - "simulations", - "exquisite", - "engineering", - "bundle", - "donor", - "hydrophobic", - "proximity", - "indicate", - "important", - "stabilization", - "depending", - "nonpolar", - "possibility", - "experiments", - "residues", - "f", - "significant", - "b", - "residue", - "purposes", - "helix", - "hyperstable", - "within", - "relative", - "pair", - "new" + "smaller", + "significant" ], "release_date":"2020-04-29", "publication":"\"Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle\", Biochemistry, 59, 1672-1679", @@ -285738,113 +286800,113 @@ ], "subtitle":"Arginine containing reengineered coiled-coiled dimer to examine the impact of proximal cation identity on hydrophobically-driven assembly", "tags":[ - "de novo peptide", "dimer", + "de novo protein", "parallel coiled-coil", - "de novo protein" + "de novo peptide" ], "keywords":[ - "oligomers", - "acidic", - "use", - "influences", - "challenge", - "acid", - "designed", - "basic", - "analogue", - "attribute", - "interact", - "nearby", - "parallel", - "constituent", - "sequences", - "findings", - "interactions", - "identifying", - "structure", - "redesign", - "rich", - "quaternary", - "achieve", - "hydrophobicity", - "forces", - "direct", - "coiled", - "lysine", - "proteins", - "arginine", - "propensities", "whether", - "almost", - "favorability", - "remains", + "redesign", + "functionality", + "hydrophobic", + "modulated", + "side", + "acid", + "arrayed", + "protein", "burial", - "necessary", - "motif", - "highlight", - "effective", - "ammonium", + "flanking", "positions", + "helical", + "dimerization", + "motif", + "identifying", "charged", - "natural", - "coils", - "versus", - "form", - "molecules", - "previously", - "impact", - "guanidinium", - "identity", - "common", - "extent", - "eliminate", + "stable", + "chains", + "bearing", + "needed", + "achieve", + "analogue", "cationic", - "juxtaposition", - "surfaces", + "govern", + "lysine", + "formed", + "nearby", + "contrasts", "dimer", + "almost", + "influences", + "residues", + "helix", + "polar", + "surfaces", + "quaternary", "universally", + "interact", + "proteins", + "use", + "extent", + "along", + "coils", + "favorability", + "unclear", + "direct", + "surface", + "effective", + "highlight", "behavior", - "observed", + "identity", "design", - "govern", - "functionality", - "helical", - "modulated", - "hydrophobic", "ask", - "surface", - "sequence", - "flanking", - "variations", - "arrayed", - "unclear", - "dimerization", + "natural", + "vs", + "constituent", + "rich", + "fold", + "driven", + "groups", + "attribute", + "hydrophobicity", "nonpolar", - "chains", + "forces", + "propensities", + "backbone", + "juxtaposition", + "noncovalent", + "parallel", + "sequence", + "common", + "versus", + "desired", + "designed", + "form", + "basic", + "sequences", "one", + "eliminate", + "observed", + "ammonium", + "oligomers", + "previously", + "remains", + "structure", + "acidic", "moderately", - "noncovalent", - "groups", - "difference", - "stable", "flexible", - "driven", - "along", - "desired", - "fold", - "residues", - "needed", - "polar", - "contrasts", - "significant", - "protein", - "backbone", - "helix", - "bearing", - "side", - "formed", - "vs" + "findings", + "impact", + "interactions", + "necessary", + "molecules", + "coiled", + "arginine", + "difference", + "guanidinium", + "challenge", + "variations", + "significant" ], "release_date":"2020-03-04", "publication":"\"Retention of Coiled-Coil Dimer Formation in the Absence of Ion Pairing at Positions Flanking the Hydrophobic Core\", Biochemistry, 58, 4821-4826", @@ -285960,86 +287022,86 @@ "helix" ], "keywords":[ - "confirm", + "engineering", + "molecular", + "role", + "hydrophobic", + "hyperstable", + "show", + "presence", + "substitutions", + "surprising", + "within", "results", + "new", + "residue", + "lys18", + "positions", + "stabilization", + "pair", + "thermodynamic", + "b", + "exquisite", + "subsequent", + "depends", + "confirm", + "crystal", + "possibility", + "simulations", + "donor", + "favorably", + "bundles", + "consider", + "nearby", + "carefully", "stabilizing", - "possibilities", - "character", - "suggest", - "still", - "substitutions", + "involving", + "purposes", + "relative", + "residues", + "helix", + "primarily", + "depending", "interact", - "smaller", - "nearby", - "crystal", - "show", - "interactions", + "large", + "suggest", + "glu10", + "possibilities", + "extent", + "suggesting", + "facilitate", + "bundle", "c", - "surprising", + "highlight", + "need", + "identity", + "proximity", + "still", + "experiments", + "complexity", + "f", + "14", + "nonpolar", + "character", + "lys7", "interaction", - "synergistic", "allows", - "consider", - "suggesting", - "lys7", - "presence", - "carefully", - "highlight", + "associated", "dynamics", + "directly", "trimeric", + "indicate", "structures", - "14", - "positions", - "complexity", - "glu10", - "lys18", - "role", - "facilitate", - "need", - "primarily", + "important", + "among", + "interactions", "impact", "plays", - "molecular", - "directly", - "involving", - "identity", - "associated", - "large", - "subsequent", - "depends", - "bundles", - "extent", - "favorably", - "thermodynamic", + "synergistic", "emphasizing", - "among", "4", - "simulations", - "exquisite", - "engineering", - "bundle", - "donor", - "hydrophobic", - "proximity", - "indicate", - "important", - "stabilization", - "depending", - "nonpolar", - "possibility", - "experiments", - "residues", - "f", - "significant", - "b", - "residue", - "purposes", - "helix", - "hyperstable", - "within", - "relative", - "pair", - "new" + "smaller", + "significant" ], "release_date":"2020-04-29", "publication":"\"Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle\", Biochemistry, 59, 1672-1679", @@ -286202,86 +287264,86 @@ "helix" ], "keywords":[ - "confirm", + "engineering", + "molecular", + "role", + "hydrophobic", + "hyperstable", + "show", + "presence", + "substitutions", + "surprising", + "within", "results", + "new", + "residue", + "lys18", + "positions", + "stabilization", + "pair", + "thermodynamic", + "b", + "exquisite", + "subsequent", + "depends", + "confirm", + "crystal", + "possibility", + "simulations", + "donor", + "favorably", + "bundles", + "consider", + "nearby", + "carefully", "stabilizing", - "possibilities", - "character", - "suggest", - "still", - "substitutions", + "involving", + "purposes", + "relative", + "residues", + "helix", + "primarily", + "depending", "interact", - "smaller", - "nearby", - "crystal", - "show", - "interactions", + "large", + "suggest", + "glu10", + "possibilities", + "extent", + "suggesting", + "facilitate", + "bundle", "c", - "surprising", + "highlight", + "need", + "identity", + "proximity", + "still", + "experiments", + "complexity", + "f", + "14", + "nonpolar", + "character", + "lys7", "interaction", - "synergistic", "allows", - "consider", - "suggesting", - "lys7", - "presence", - "carefully", - "highlight", + "associated", "dynamics", + "directly", "trimeric", + "indicate", "structures", - "14", - "positions", - "complexity", - "glu10", - "lys18", - "role", - "facilitate", - "need", - "primarily", + "important", + "among", + "interactions", "impact", "plays", - "molecular", - "directly", - "involving", - "identity", - "associated", - "large", - "subsequent", - "depends", - "bundles", - "extent", - "favorably", - "thermodynamic", + "synergistic", "emphasizing", - "among", "4", - "simulations", - "exquisite", - "engineering", - "bundle", - "donor", - "hydrophobic", - "proximity", - "indicate", - "important", - "stabilization", - "depending", - "nonpolar", - "possibility", - "experiments", - "residues", - "f", - "significant", - "b", - "residue", - "purposes", - "helix", - "hyperstable", - "within", - "relative", - "pair", - "new" + "smaller", + "significant" ], "release_date":"2020-04-29", "publication":"\"Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle\", Biochemistry, 59, 1672-1679", @@ -286460,86 +287522,86 @@ "helix" ], "keywords":[ - "confirm", + "engineering", + "molecular", + "role", + "hydrophobic", + "hyperstable", + "show", + "presence", + "substitutions", + "surprising", + "within", "results", + "new", + "residue", + "lys18", + "positions", + "stabilization", + "pair", + "thermodynamic", + "b", + "exquisite", + "subsequent", + "depends", + "confirm", + "crystal", + "possibility", + "simulations", + "donor", + "favorably", + "bundles", + "consider", + "nearby", + "carefully", "stabilizing", - "possibilities", - "character", - "suggest", - "still", - "substitutions", + "involving", + "purposes", + "relative", + "residues", + "helix", + "primarily", + "depending", "interact", - "smaller", - "nearby", - "crystal", - "show", - "interactions", + "large", + "suggest", + "glu10", + "possibilities", + "extent", + "suggesting", + "facilitate", + "bundle", "c", - "surprising", + "highlight", + "need", + "identity", + "proximity", + "still", + "experiments", + "complexity", + "f", + "14", + "nonpolar", + "character", + "lys7", "interaction", - "synergistic", "allows", - "consider", - "suggesting", - "lys7", - "presence", - "carefully", - "highlight", + "associated", "dynamics", + "directly", "trimeric", + "indicate", "structures", - "14", - "positions", - "complexity", - "glu10", - "lys18", - "role", - "facilitate", - "need", - "primarily", + "important", + "among", + "interactions", "impact", "plays", - "molecular", - "directly", - "involving", - "identity", - "associated", - "large", - "subsequent", - "depends", - "bundles", - "extent", - "favorably", - "thermodynamic", + "synergistic", "emphasizing", - "among", "4", - "simulations", - "exquisite", - "engineering", - "bundle", - "donor", - "hydrophobic", - "proximity", - "indicate", - "important", - "stabilization", - "depending", - "nonpolar", - "possibility", - "experiments", - "residues", - "f", - "significant", - "b", - "residue", - "purposes", - "helix", - "hyperstable", - "within", - "relative", - "pair", - "new" + "smaller", + "significant" ], "release_date":"2020-04-29", "publication":"\"Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle\", Biochemistry, 59, 1672-1679", @@ -286709,109 +287771,109 @@ ], "subtitle":"Crystal structure of a cc-hex mutant that forms an antiparallel four-helix coiled coil cc-hex*-l24d", "tags":[ - "antiparallel", + "coiled coil", "tetramer", + "antiparallel", "de novo protein", - "coiled coil", "synthetic", "cc-hex" ], "keywords":[ - "analysis", - "tetramer", - "cases", - "amphipathic", - "us", - "extreme", - "established", - "discriminate", - "peptide", - "example", - "robust", - "hexamers", - "parallel", - "crystal", - "increasingly", - "dominate", - "synthetic", + "dimers", + "engineering", + "driving", + "hydrophobic", + "structural", + "hyperstable", + "resolution", + "number", + "well", + "rationally", + "helps", + "various", + "protein", + "discerned", + "changes", + "fully", + "navigation", "\u03b1", - "structurally", - "allowed", - "leads", - "however", - "mixed", + "ubiquitous", + "novo", + "crystal", + "helices", + "robust", + "water", "alternative", - "coiled", - "de", - "main", - "tetramers", + "antiparallel", "characterized", + "however", + "formed", + "us", + "define", + "accessible", + "specific", + "hexamers", + "trimers", "response", - "less", - "number", - "orientation", - "fully", - "nature", - "relationships", - "structures", - "driving", - "coils", - "solution", - "force", - "biology", "achieved", - "nevertheless", + "tetramers", + "established", + "scaffold", + "mixed", + "coils", + "inspection", + "switches", + "peptide", + "tetramer", + "design", "another", + "provides", + "discriminate", "functional", - "associated", + "biology", + "different", + "leads", + "variant", + "orientation", + "extreme", + "relationships", + "solution", + "understood", "conditions", - "changes", - "resolution", - "class", - "define", - "trimers", - "landscape", - "specific", - "engineering", - "helps", - "provides", - "design", - "deeper", - "rather", - "rationally", + "parallel", "states", - "hydrophobic", - "switches", - "association", - "describe", - "high", + "system", "rationalize", - "ubiquitous", - "known", - "structural", - "variant", - "designs", - "discerned", + "dominate", + "landscape", + "nevertheless", + "describe", + "associated", + "amphipathic", + "analysis", + "example", "one", - "helices", - "accessible", - "novo", - "well", - "different", - "understood", - "dimers", - "antiparallel", - "system", + "association", + "main", + "rather", + "structurally", + "structures", + "deeper", + "de", + "allowed", + "synthetic", "state", + "nature", + "known", + "cases", + "class", + "force", + "coiled", + "high", + "increasingly", "arrangements", - "scaffold", - "inspection", - "navigation", - "protein", - "water", - "various", - "hyperstable", - "formed" + "designs", + "less" ], "release_date":"2019-05-22", "publication":"\"Navigating the Structural Landscape of De Novo alpha-Helical Bundles\", J.Am.Chem.Soc., 141, 8787-8797", @@ -287085,109 +288147,109 @@ ], "subtitle":"Crystal structure of a cc-hex mutant that forms an antiparallel four-helix coiled coil cc-hex*-l24e", "tags":[ - "antiparallel", + "coiled coil", "tetramer", + "antiparallel", "de novo protein", - "coiled coil", "synthetic", "cc-hex" ], "keywords":[ - "analysis", - "tetramer", - "cases", - "amphipathic", - "us", - "extreme", - "established", - "discriminate", - "peptide", - "example", - "robust", - "hexamers", - "parallel", - "crystal", - "increasingly", - "dominate", - "synthetic", + "dimers", + "engineering", + "driving", + "hydrophobic", + "structural", + "hyperstable", + "resolution", + "number", + "well", + "rationally", + "helps", + "various", + "protein", + "discerned", + "changes", + "fully", + "navigation", "\u03b1", - "structurally", - "allowed", - "leads", - "however", - "mixed", + "ubiquitous", + "novo", + "crystal", + "helices", + "robust", + "water", "alternative", - "coiled", - "de", - "main", - "tetramers", + "antiparallel", "characterized", + "however", + "formed", + "us", + "define", + "accessible", + "specific", + "hexamers", + "trimers", "response", - "less", - "number", - "orientation", - "fully", - "nature", - "relationships", - "structures", - "driving", - "coils", - "solution", - "force", - "biology", "achieved", - "nevertheless", + "tetramers", + "established", + "scaffold", + "mixed", + "coils", + "inspection", + "switches", + "peptide", + "tetramer", + "design", "another", + "provides", + "discriminate", "functional", - "associated", + "biology", + "different", + "leads", + "variant", + "orientation", + "extreme", + "relationships", + "solution", + "understood", "conditions", - "changes", - "resolution", - "class", - "define", - "trimers", - "landscape", - "specific", - "engineering", - "helps", - "provides", - "design", - "deeper", - "rather", - "rationally", + "parallel", "states", - "hydrophobic", - "switches", - "association", - "describe", - "high", + "system", "rationalize", - "ubiquitous", - "known", - "structural", - "variant", - "designs", - "discerned", + "dominate", + "landscape", + "nevertheless", + "describe", + "associated", + "amphipathic", + "analysis", + "example", "one", - "helices", - "accessible", - "novo", - "well", - "different", - "understood", - "dimers", - "antiparallel", - "system", + "association", + "main", + "rather", + "structurally", + "structures", + "deeper", + "de", + "allowed", + "synthetic", "state", + "nature", + "known", + "cases", + "class", + "force", + "coiled", + "high", + "increasingly", "arrangements", - "scaffold", - "inspection", - "navigation", - "protein", - "water", - "various", - "hyperstable", - "formed" + "designs", + "less" ], "release_date":"2019-05-22", "publication":"\"Navigating the Structural Landscape of De Novo alpha-Helical Bundles\", J.Am.Chem.Soc., 141, 8787-8797", @@ -287376,11 +288438,11 @@ "struct_thr_sim_natural":[ { "sim":1.0, - "partner":"4kvv" + "partner":"4kvt" }, { "sim":1.0, - "partner":"4kvt" + "partner":"4kvv" }, { "sim":1.0, @@ -287465,109 +288527,109 @@ ], "subtitle":"Crystal structure of a cc-hex mutant that forms a parallel six-helix coiled coil cc-hex*-l24e", "tags":[ - "parallel", - "de novo protein", "coiled coil", + "de novo protein", "synthetic", + "cc-hex", "hexamer", - "cc-hex" + "parallel" ], "keywords":[ - "analysis", - "tetramer", - "cases", - "amphipathic", - "us", - "extreme", - "established", - "discriminate", - "peptide", - "example", - "robust", - "hexamers", - "parallel", - "crystal", - "increasingly", - "dominate", - "synthetic", + "dimers", + "engineering", + "driving", + "hydrophobic", + "structural", + "hyperstable", + "resolution", + "number", + "well", + "rationally", + "helps", + "various", + "protein", + "discerned", + "changes", + "fully", + "navigation", "\u03b1", - "structurally", - "allowed", - "leads", - "however", - "mixed", + "ubiquitous", + "novo", + "crystal", + "helices", + "robust", + "water", "alternative", - "coiled", - "de", - "main", - "tetramers", + "antiparallel", "characterized", + "however", + "formed", + "us", + "define", + "accessible", + "specific", + "hexamers", + "trimers", "response", - "less", - "number", - "orientation", - "fully", - "nature", - "relationships", - "structures", - "driving", - "coils", - "solution", - "force", - "biology", "achieved", - "nevertheless", + "tetramers", + "established", + "scaffold", + "mixed", + "coils", + "inspection", + "switches", + "peptide", + "tetramer", + "design", "another", + "provides", + "discriminate", "functional", - "associated", + "biology", + "different", + "leads", + "variant", + "orientation", + "extreme", + "relationships", + "solution", + "understood", "conditions", - "changes", - "resolution", - "class", - "define", - "trimers", - "landscape", - "specific", - "engineering", - "helps", - "provides", - "design", - "deeper", - "rather", - "rationally", + "parallel", "states", - "hydrophobic", - "switches", - "association", - "describe", - "high", + "system", "rationalize", - "ubiquitous", - "known", - "structural", - "variant", - "designs", - "discerned", + "dominate", + "landscape", + "nevertheless", + "describe", + "associated", + "amphipathic", + "analysis", + "example", "one", - "helices", - "accessible", - "novo", - "well", - "different", - "understood", - "dimers", - "antiparallel", - "system", + "association", + "main", + "rather", + "structurally", + "structures", + "deeper", + "de", + "allowed", + "synthetic", "state", + "nature", + "known", + "cases", + "class", + "force", + "coiled", + "high", + "increasingly", "arrangements", - "scaffold", - "inspection", - "navigation", - "protein", - "water", - "various", - "hyperstable", - "formed" + "designs", + "less" ], "release_date":"2019-05-22", "publication":"\"Navigating the Structural Landscape of De Novo alpha-Helical Bundles\", J.Am.Chem.Soc., 141, 8787-8797", @@ -287604,38 +288666,6 @@ ], "struct_thr_sim_designed":[ - { - "sim":0.9896000028, - "partner":"6q5h" - }, - { - "sim":0.9718999863, - "partner":"6q5i" - }, - { - "sim":0.962199986, - "partner":"6q5k" - }, - { - "sim":0.956799984, - "partner":"6q5l" - }, - { - "sim":0.969900012, - "partner":"6q5m" - }, - { - "sim":0.9631999731, - "partner":"4h8l" - }, - { - "sim":0.9721000195, - "partner":"8a3j" - }, - { - "sim":0.9735000134, - "partner":"8a3i" - }, { "sim":1.0, "partner":"3r46" @@ -287670,15 +288700,15 @@ }, { "sim":1.0, - "partner":"4h8g" + "partner":"4h7r" }, { "sim":1.0, - "partner":"6q5r" + "partner":"4h8g" }, { "sim":1.0, - "partner":"4h7r" + "partner":"6q5r" }, { "sim":0.9575999975, @@ -287708,6 +288738,10 @@ "sim":1.0, "partner":"8qaa" }, + { + "sim":0.9575999975, + "partner":"8qac" + }, { "sim":0.9575999975, "partner":"5eon" @@ -287716,14 +288750,18 @@ "sim":0.9897000194, "partner":"3r4h" }, - { - "sim":0.9575999975, - "partner":"8qac" - }, { "sim":1.0, "partner":"8qab" }, + { + "sim":0.9549000263, + "partner":"5eoj" + }, + { + "sim":0.9557999969, + "partner":"5vte" + }, { "sim":0.9919999838, "partner":"6i1j" @@ -287732,17 +288770,41 @@ "sim":0.9972000122, "partner":"4dzl" }, - { - "sim":0.9557999969, - "partner":"5vte" - }, { "sim":1.0, "partner":"7qdk" }, { - "sim":0.9549000263, - "partner":"5eoj" + "sim":0.9896000028, + "partner":"6q5h" + }, + { + "sim":0.9718999863, + "partner":"6q5i" + }, + { + "sim":0.962199986, + "partner":"6q5k" + }, + { + "sim":0.956799984, + "partner":"6q5l" + }, + { + "sim":0.969900012, + "partner":"6q5m" + }, + { + "sim":0.9631999731, + "partner":"4h8l" + }, + { + "sim":0.9721000195, + "partner":"8a3j" + }, + { + "sim":0.9735000134, + "partner":"8a3i" } ], "struct_thr_sim_natural":[ @@ -287767,7 +288829,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"6q5n" + "partner":"3r46" }, "struct_max_sim_natural":{ "sim":1.0, @@ -287837,109 +288899,109 @@ ], "subtitle":"Crystal structure of a cc-hex mutant that forms an antiparallel four-helix coiled coil cc-hex*-l24k", "tags":[ - "antiparallel", + "coiled coil", "tetramer", + "antiparallel", "de novo protein", - "coiled coil", "synthetic", "cc-hex" ], "keywords":[ - "analysis", - "tetramer", - "cases", - "amphipathic", - "us", - "extreme", - "established", - "discriminate", - "peptide", - "example", - "robust", - "hexamers", - "parallel", - "crystal", - "increasingly", - "dominate", - "synthetic", + "dimers", + "engineering", + "driving", + "hydrophobic", + "structural", + "hyperstable", + "resolution", + "number", + "well", + "rationally", + "helps", + "various", + "protein", + "discerned", + "changes", + "fully", + "navigation", "\u03b1", - "structurally", - "allowed", - "leads", - "however", - "mixed", + "ubiquitous", + "novo", + "crystal", + "helices", + "robust", + "water", "alternative", - "coiled", - "de", - "main", - "tetramers", + "antiparallel", "characterized", + "however", + "formed", + "us", + "define", + "accessible", + "specific", + "hexamers", + "trimers", "response", - "less", - "number", - "orientation", - "fully", - "nature", - "relationships", - "structures", - "driving", - "coils", - "solution", - "force", - "biology", "achieved", - "nevertheless", + "tetramers", + "established", + "scaffold", + "mixed", + "coils", + "inspection", + "switches", + "peptide", + "tetramer", + "design", "another", + "provides", + "discriminate", "functional", - "associated", + "biology", + "different", + "leads", + "variant", + "orientation", + "extreme", + "relationships", + "solution", + "understood", "conditions", - "changes", - "resolution", - "class", - "define", - "trimers", - "landscape", - "specific", - "engineering", - "helps", - "provides", - "design", - "deeper", - "rather", - "rationally", + "parallel", "states", - "hydrophobic", - "switches", - "association", - "describe", - "high", + "system", "rationalize", - "ubiquitous", - "known", - "structural", - "variant", - "designs", - "discerned", + "dominate", + "landscape", + "nevertheless", + "describe", + "associated", + "amphipathic", + "analysis", + "example", "one", - "helices", - "accessible", - "novo", - "well", - "different", - "understood", - "dimers", - "antiparallel", - "system", + "association", + "main", + "rather", + "structurally", + "structures", + "deeper", + "de", + "allowed", + "synthetic", "state", + "nature", + "known", + "cases", + "class", + "force", + "coiled", + "high", + "increasingly", "arrangements", - "scaffold", - "inspection", - "navigation", - "protein", - "water", - "various", - "hyperstable", - "formed" + "designs", + "less" ], "release_date":"2019-05-22", "publication":"\"Navigating the Structural Landscape of De Novo alpha-Helical Bundles\", J.Am.Chem.Soc., 141, 8787-8797", @@ -287977,108 +289039,84 @@ ], "struct_thr_sim_designed":[ { - "sim":1.0, - "partner":"6q5i" - }, - { - "sim":0.9603999853, - "partner":"6q5m" + "sim":0.9988999963, + "partner":"3r47" }, { "sim":0.9972000122, "partner":"6q5h" }, { - "sim":0.9769999981, - "partner":"6q5l" + "sim":1.0, + "partner":"6q5i" }, { - "sim":0.9988999963, - "partner":"3r47" + "sim":0.9986000061, + "partner":"6q5n" }, { "sim":0.9986000061, - "partner":"6q5n" + "partner":"4h8m" }, { "sim":0.9970999956, "partner":"3r48" }, + { + "sim":0.9968000054, + "partner":"3r46" + }, { "sim":0.9986000061, "partner":"6q5j" }, { "sim":0.9986000061, - "partner":"4h8m" + "partner":"6q5p" }, { - "sim":0.9968000054, - "partner":"3r46" + "sim":1.0, + "partner":"4h7r" }, { "sim":0.9973000288, "partner":"3r3k" }, { - "sim":0.9986000061, - "partner":"6q5p" - }, - { - "sim":1.0, - "partner":"4h7r" + "sim":0.9728999734, + "partner":"4h8g" }, { "sim":0.9743999839, "partner":"6q5s" }, { - "sim":0.9804000258, - "partner":"4h8l" - }, - { - "sim":0.9728999734, - "partner":"4h8g" + "sim":0.9966999888, + "partner":"3r4a" }, { - "sim":1.0, - "partner":"8a3g" + "sim":0.9804000258, + "partner":"4h8l" }, { "sim":0.9957000017, "partner":"4h8f" }, - { - "sim":0.9743999839, - "partner":"6q5r" - }, { "sim":0.9986000061, "partner":"4h8o" }, { - "sim":0.9966999888, - "partner":"3r4a" - }, - { - "sim":0.9829000235, - "partner":"8bcs" + "sim":1.0, + "partner":"8a3g" }, { "sim":0.9958000183, "partner":"3r4h" }, { - "sim":1.0, - "partner":"4dzl" - }, - { - "sim":0.9972000122, - "partner":"4dzk" - }, - { - "sim":0.986899972, - "partner":"6i1j" + "sim":0.9743999839, + "partner":"6q5r" }, { "sim":0.9509000182, @@ -288099,6 +289137,30 @@ { "sim":0.9986000061, "partner":"8qab" + }, + { + "sim":0.986899972, + "partner":"6i1j" + }, + { + "sim":1.0, + "partner":"4dzl" + }, + { + "sim":0.9972000122, + "partner":"4dzk" + }, + { + "sim":0.9603999853, + "partner":"6q5m" + }, + { + "sim":0.9769999981, + "partner":"6q5l" + }, + { + "sim":0.9829000235, + "partner":"8bcs" } ], "struct_thr_sim_natural":[ @@ -288193,109 +289255,109 @@ ], "subtitle":"Crystal structure of a cc-hex mutant that forms an antiparallel four-helix coiled coil cc-hex*-l24h", "tags":[ - "antiparallel", + "coiled coil", "tetramer", + "antiparallel", "de novo protein", - "coiled coil", "synthetic", "cc-hex" ], "keywords":[ - "analysis", - "tetramer", - "cases", - "amphipathic", - "us", - "extreme", - "established", - "discriminate", - "peptide", - "example", - "robust", - "hexamers", - "parallel", - "crystal", - "increasingly", - "dominate", - "synthetic", + "dimers", + "engineering", + "driving", + "hydrophobic", + "structural", + "hyperstable", + "resolution", + "number", + "well", + "rationally", + "helps", + "various", + "protein", + "discerned", + "changes", + "fully", + "navigation", "\u03b1", - "structurally", - "allowed", - "leads", - "however", - "mixed", + "ubiquitous", + "novo", + "crystal", + "helices", + "robust", + "water", "alternative", - "coiled", - "de", - "main", - "tetramers", + "antiparallel", "characterized", + "however", + "formed", + "us", + "define", + "accessible", + "specific", + "hexamers", + "trimers", "response", - "less", - "number", - "orientation", - "fully", - "nature", - "relationships", - "structures", - "driving", - "coils", - "solution", - "force", - "biology", "achieved", - "nevertheless", + "tetramers", + "established", + "scaffold", + "mixed", + "coils", + "inspection", + "switches", + "peptide", + "tetramer", + "design", "another", + "provides", + "discriminate", "functional", - "associated", + "biology", + "different", + "leads", + "variant", + "orientation", + "extreme", + "relationships", + "solution", + "understood", "conditions", - "changes", - "resolution", - "class", - "define", - "trimers", - "landscape", - "specific", - "engineering", - "helps", - "provides", - "design", - "deeper", - "rather", - "rationally", + "parallel", "states", - "hydrophobic", - "switches", - "association", - "describe", - "high", + "system", "rationalize", - "ubiquitous", - "known", - "structural", - "variant", - "designs", - "discerned", + "dominate", + "landscape", + "nevertheless", + "describe", + "associated", + "amphipathic", + "analysis", + "example", "one", - "helices", - "accessible", - "novo", - "well", - "different", - "understood", - "dimers", - "antiparallel", - "system", + "association", + "main", + "rather", + "structurally", + "structures", + "deeper", + "de", + "allowed", + "synthetic", "state", + "nature", + "known", + "cases", + "class", + "force", + "coiled", + "high", + "increasingly", "arrangements", - "scaffold", - "inspection", - "navigation", - "protein", - "water", - "various", - "hyperstable", - "formed" + "designs", + "less" ], "release_date":"2019-05-22", "publication":"\"Navigating the Structural Landscape of De Novo alpha-Helical Bundles\", J.Am.Chem.Soc., 141, 8787-8797", @@ -288486,109 +289548,109 @@ ], "subtitle":"Crystal structure of a cc-hex mutant that forms an antiparallel four-helix coiled coil cc-hex*-l24dab", "tags":[ - "antiparallel", + "coiled coil", "tetramer", + "antiparallel", "de novo protein", - "coiled coil", "synthetic", "cc-hex" ], "keywords":[ - "analysis", - "tetramer", - "cases", - "amphipathic", - "us", - "extreme", - "established", - "discriminate", - "peptide", - "example", - "robust", - "hexamers", - "parallel", - "crystal", - "increasingly", - "dominate", - "synthetic", + "dimers", + "engineering", + "driving", + "hydrophobic", + "structural", + "hyperstable", + "resolution", + "number", + "well", + "rationally", + "helps", + "various", + "protein", + "discerned", + "changes", + "fully", + "navigation", "\u03b1", - "structurally", - "allowed", - "leads", - "however", - "mixed", + "ubiquitous", + "novo", + "crystal", + "helices", + "robust", + "water", "alternative", - "coiled", - "de", - "main", - "tetramers", + "antiparallel", "characterized", + "however", + "formed", + "us", + "define", + "accessible", + "specific", + "hexamers", + "trimers", "response", - "less", - "number", - "orientation", - "fully", - "nature", - "relationships", - "structures", - "driving", - "coils", - "solution", - "force", - "biology", "achieved", - "nevertheless", + "tetramers", + "established", + "scaffold", + "mixed", + "coils", + "inspection", + "switches", + "peptide", + "tetramer", + "design", "another", + "provides", + "discriminate", "functional", - "associated", + "biology", + "different", + "leads", + "variant", + "orientation", + "extreme", + "relationships", + "solution", + "understood", "conditions", - "changes", - "resolution", - "class", - "define", - "trimers", - "landscape", - "specific", - "engineering", - "helps", - "provides", - "design", - "deeper", - "rather", - "rationally", + "parallel", "states", - "hydrophobic", - "switches", - "association", - "describe", - "high", + "system", "rationalize", - "ubiquitous", - "known", - "structural", - "variant", - "designs", - "discerned", + "dominate", + "landscape", + "nevertheless", + "describe", + "associated", + "amphipathic", + "analysis", + "example", "one", - "helices", - "accessible", - "novo", - "well", - "different", - "understood", - "dimers", - "antiparallel", - "system", + "association", + "main", + "rather", + "structurally", + "structures", + "deeper", + "de", + "allowed", + "synthetic", "state", + "nature", + "known", + "cases", + "class", + "force", + "coiled", + "high", + "increasingly", "arrangements", - "scaffold", - "inspection", - "navigation", - "protein", - "water", - "various", - "hyperstable", - "formed" + "designs", + "less" ], "release_date":"2019-05-22", "publication":"\"Navigating the Structural Landscape of De Novo alpha-Helical Bundles\", J.Am.Chem.Soc., 141, 8787-8797", @@ -288854,108 +289916,108 @@ ], "subtitle":"Crystal structure of a cc-hex mutant that forms a parallel six-helix coiled coil cc-hex*-l24nle", "tags":[ - "de novo protein", "coiled coil", + "de novo protein", "synthetic", - "hexamer", - "cc-hex" + "cc-hex", + "hexamer" ], "keywords":[ - "analysis", - "tetramer", - "cases", - "amphipathic", - "us", - "extreme", - "established", - "discriminate", - "peptide", - "example", - "robust", - "hexamers", - "parallel", - "crystal", - "increasingly", - "dominate", - "synthetic", + "dimers", + "engineering", + "driving", + "hydrophobic", + "structural", + "hyperstable", + "resolution", + "number", + "well", + "rationally", + "helps", + "various", + "protein", + "discerned", + "changes", + "fully", + "navigation", "\u03b1", - "structurally", - "allowed", - "leads", - "however", - "mixed", + "ubiquitous", + "novo", + "crystal", + "helices", + "robust", + "water", "alternative", - "coiled", - "de", - "main", - "tetramers", + "antiparallel", "characterized", + "however", + "formed", + "us", + "define", + "accessible", + "specific", + "hexamers", + "trimers", "response", - "less", - "number", - "orientation", - "fully", - "nature", - "relationships", - "structures", - "driving", - "coils", - "solution", - "force", - "biology", "achieved", - "nevertheless", + "tetramers", + "established", + "scaffold", + "mixed", + "coils", + "inspection", + "switches", + "peptide", + "tetramer", + "design", "another", + "provides", + "discriminate", "functional", - "associated", + "biology", + "different", + "leads", + "variant", + "orientation", + "extreme", + "relationships", + "solution", + "understood", "conditions", - "changes", - "resolution", - "class", - "define", - "trimers", - "landscape", - "specific", - "engineering", - "helps", - "provides", - "design", - "deeper", - "rather", - "rationally", + "parallel", "states", - "hydrophobic", - "switches", - "association", - "describe", - "high", + "system", "rationalize", - "ubiquitous", - "known", - "structural", - "variant", - "designs", - "discerned", + "dominate", + "landscape", + "nevertheless", + "describe", + "associated", + "amphipathic", + "analysis", + "example", "one", - "helices", - "accessible", - "novo", - "well", - "different", - "understood", - "dimers", - "antiparallel", - "system", + "association", + "main", + "rather", + "structurally", + "structures", + "deeper", + "de", + "allowed", + "synthetic", "state", - "arrangements", - "scaffold", - "inspection", - "navigation", - "protein", - "water", - "various", - "hyperstable", - "formed" + "nature", + "known", + "cases", + "class", + "force", + "coiled", + "high", + "increasingly", + "arrangements", + "designs", + "less" ], "release_date":"2019-05-22", "publication":"\"Navigating the Structural Landscape of De Novo alpha-Helical Bundles\", J.Am.Chem.Soc., 141, 8787-8797", @@ -288992,10 +290054,18 @@ ], "struct_thr_sim_designed":[ + { + "sim":1.0, + "partner":"3r47" + }, { "sim":1.0, "partner":"3r48" }, + { + "sim":1.0, + "partner":"4h8g" + }, { "sim":1.0, "partner":"3r3k" @@ -289012,10 +290082,6 @@ "sim":1.0, "partner":"3r46" }, - { - "sim":1.0, - "partner":"4h8g" - }, { "sim":1.0, "partner":"4h8m" @@ -289030,87 +290096,79 @@ }, { "sim":1.0, - "partner":"6q5j" + "partner":"4h7r" }, { "sim":1.0, - "partner":"3r47" + "partner":"6q5j" }, { - "sim":1.0, - "partner":"4h7r" + "sim":0.9559999704, + "partner":"6q5h" + }, + { + "sim":0.9526000023, + "partner":"6q5i" }, { "sim":1.0, - "partner":"6q5r" + "partner":"4h8f" }, { "sim":1.0, - "partner":"4h8o" + "partner":"6q5r" }, { - "sim":0.9965999722, - "partner":"3r4a" + "sim":1.0, + "partner":"8qac" }, { "sim":1.0, - "partner":"4h8f" + "partner":"4h8o" }, { "sim":0.9785000086, "partner":"6q5q" }, { - "sim":1.0, - "partner":"8qac" + "sim":0.9559999704, + "partner":"5eon" + }, + { + "sim":0.9965999722, + "partner":"3r4a" }, { "sim":0.9862999916, "partner":"3r4h" }, { - "sim":1.0, - "partner":"8qaa" + "sim":0.9559999704, + "partner":"5eoj" }, { - "sim":1.0, - "partner":"8qab" + "sim":0.9559999704, + "partner":"5vte" }, { - "sim":0.9919999838, - "partner":"6i1j" + "sim":1.0, + "partner":"8qab" }, { "sim":1.0, - "partner":"4dzl" + "partner":"8qaa" }, { "sim":0.993900001, "partner":"4dzk" }, { - "sim":1.0, - "partner":"7qdk" - }, - { - "sim":0.9559999704, - "partner":"6q5h" - }, - { - "sim":0.9526000023, - "partner":"6q5i" - }, - { - "sim":0.9559999704, - "partner":"5eon" - }, - { - "sim":0.9559999704, - "partner":"5eoj" + "sim":0.9919999838, + "partner":"6i1j" }, { - "sim":0.9559999704, - "partner":"5vte" + "sim":1.0, + "partner":"4dzl" }, { "sim":0.9559999704, @@ -289119,6 +290177,10 @@ { "sim":0.9559999704, "partner":"8qad" + }, + { + "sim":1.0, + "partner":"7qdk" } ], "struct_thr_sim_natural":[ @@ -289213,109 +290275,109 @@ ], "subtitle":"Crystal structure of a cc-hex mutant that forms an antiparallel four-helix coiled coil cc-hex*-ll", "tags":[ - "antiparallel", + "coiled coil", "tetramer", + "antiparallel", "de novo protein", - "coiled coil", "synthetic", "cc-hex" ], "keywords":[ - "analysis", - "tetramer", - "cases", - "amphipathic", - "us", - "extreme", - "established", - "discriminate", - "peptide", - "example", - "robust", - "hexamers", - "parallel", - "crystal", - "increasingly", - "dominate", - "synthetic", + "dimers", + "engineering", + "driving", + "hydrophobic", + "structural", + "hyperstable", + "resolution", + "number", + "well", + "rationally", + "helps", + "various", + "protein", + "discerned", + "changes", + "fully", + "navigation", "\u03b1", - "structurally", - "allowed", - "leads", - "however", - "mixed", + "ubiquitous", + "novo", + "crystal", + "helices", + "robust", + "water", "alternative", - "coiled", - "de", - "main", - "tetramers", + "antiparallel", "characterized", + "however", + "formed", + "us", + "define", + "accessible", + "specific", + "hexamers", + "trimers", "response", - "less", - "number", - "orientation", - "fully", - "nature", - "relationships", - "structures", - "driving", - "coils", - "solution", - "force", - "biology", "achieved", - "nevertheless", + "tetramers", + "established", + "scaffold", + "mixed", + "coils", + "inspection", + "switches", + "peptide", + "tetramer", + "design", "another", + "provides", + "discriminate", "functional", - "associated", + "biology", + "different", + "leads", + "variant", + "orientation", + "extreme", + "relationships", + "solution", + "understood", "conditions", - "changes", - "resolution", - "class", - "define", - "trimers", - "landscape", - "specific", - "engineering", - "helps", - "provides", - "design", - "deeper", - "rather", - "rationally", + "parallel", "states", - "hydrophobic", - "switches", - "association", - "describe", - "high", + "system", "rationalize", - "ubiquitous", - "known", - "structural", - "variant", - "designs", - "discerned", + "dominate", + "landscape", + "nevertheless", + "describe", + "associated", + "amphipathic", + "analysis", + "example", "one", - "helices", - "accessible", - "novo", - "well", - "different", - "understood", - "dimers", - "antiparallel", - "system", + "association", + "main", + "rather", + "structurally", + "structures", + "deeper", + "de", + "allowed", + "synthetic", "state", + "nature", + "known", + "cases", + "class", + "force", + "coiled", + "high", + "increasingly", "arrangements", - "scaffold", - "inspection", - "navigation", - "protein", - "water", - "various", - "hyperstable", - "formed" + "designs", + "less" ], "release_date":"2019-05-22", "publication":"\"Navigating the Structural Landscape of De Novo alpha-Helical Bundles\", J.Am.Chem.Soc., 141, 8787-8797", @@ -289557,109 +290619,109 @@ ], "subtitle":"Crystal structure of a cc-hex mutant that forms a parallel six-helix coiled coil cc-hex*-ii", "tags":[ - "parallel", - "de novo protein", "coiled coil", + "de novo protein", "synthetic", + "cc-hex", "hexamer", - "cc-hex" + "parallel" ], "keywords":[ - "analysis", - "tetramer", - "cases", - "amphipathic", - "us", - "extreme", - "established", - "discriminate", - "peptide", - "example", - "robust", - "hexamers", - "parallel", - "crystal", - "increasingly", - "dominate", - "synthetic", + "dimers", + "engineering", + "driving", + "hydrophobic", + "structural", + "hyperstable", + "resolution", + "number", + "well", + "rationally", + "helps", + "various", + "protein", + "discerned", + "changes", + "fully", + "navigation", "\u03b1", - "structurally", - "allowed", - "leads", - "however", - "mixed", + "ubiquitous", + "novo", + "crystal", + "helices", + "robust", + "water", "alternative", - "coiled", - "de", - "main", - "tetramers", + "antiparallel", "characterized", + "however", + "formed", + "us", + "define", + "accessible", + "specific", + "hexamers", + "trimers", "response", - "less", - "number", - "orientation", - "fully", - "nature", - "relationships", - "structures", - "driving", - "coils", - "solution", - "force", - "biology", "achieved", - "nevertheless", + "tetramers", + "established", + "scaffold", + "mixed", + "coils", + "inspection", + "switches", + "peptide", + "tetramer", + "design", "another", + "provides", + "discriminate", "functional", - "associated", + "biology", + "different", + "leads", + "variant", + "orientation", + "extreme", + "relationships", + "solution", + "understood", "conditions", - "changes", - "resolution", - "class", - "define", - "trimers", - "landscape", - "specific", - "engineering", - "helps", - "provides", - "design", - "deeper", - "rather", - "rationally", + "parallel", "states", - "hydrophobic", - "switches", - "association", - "describe", - "high", + "system", "rationalize", - "ubiquitous", - "known", - "structural", - "variant", - "designs", - "discerned", + "dominate", + "landscape", + "nevertheless", + "describe", + "associated", + "amphipathic", + "analysis", + "example", "one", - "helices", - "accessible", - "novo", - "well", - "different", - "understood", - "dimers", - "antiparallel", - "system", + "association", + "main", + "rather", + "structurally", + "structures", + "deeper", + "de", + "allowed", + "synthetic", "state", + "nature", + "known", + "cases", + "class", + "force", + "coiled", + "high", + "increasingly", "arrangements", - "scaffold", - "inspection", - "navigation", - "protein", - "water", - "various", - "hyperstable", - "formed" + "designs", + "less" ], "release_date":"2019-05-22", "publication":"\"Navigating the Structural Landscape of De Novo alpha-Helical Bundles\", J.Am.Chem.Soc., 141, 8787-8797", @@ -289901,108 +290963,108 @@ ], "subtitle":"Crystal structure of a cc-hex mutant that forms an antiparallel four-helix coiled coil cc-hex-kgeb", "tags":[ - "antiparallel", + "coiled coil", "tetramer", + "antiparallel", "de novo protein", - "coiled coil", "synthetic" ], "keywords":[ - "analysis", - "tetramer", - "cases", - "amphipathic", - "us", - "extreme", - "established", - "discriminate", - "peptide", - "example", - "robust", - "hexamers", - "parallel", - "crystal", - "increasingly", - "dominate", - "synthetic", + "dimers", + "engineering", + "driving", + "hydrophobic", + "structural", + "hyperstable", + "resolution", + "number", + "well", + "rationally", + "helps", + "various", + "protein", + "discerned", + "changes", + "fully", + "navigation", "\u03b1", - "structurally", - "allowed", - "leads", - "however", - "mixed", + "ubiquitous", + "novo", + "crystal", + "helices", + "robust", + "water", "alternative", - "coiled", - "de", - "main", - "tetramers", + "antiparallel", "characterized", + "however", + "formed", + "us", + "define", + "accessible", + "specific", + "hexamers", + "trimers", "response", - "less", - "number", - "orientation", - "fully", - "nature", - "relationships", - "structures", - "driving", - "coils", - "solution", - "force", - "biology", "achieved", - "nevertheless", + "tetramers", + "established", + "scaffold", + "mixed", + "coils", + "inspection", + "switches", + "peptide", + "tetramer", + "design", "another", + "provides", + "discriminate", "functional", - "associated", + "biology", + "different", + "leads", + "variant", + "orientation", + "extreme", + "relationships", + "solution", + "understood", "conditions", - "changes", - "resolution", - "class", - "define", - "trimers", - "landscape", - "specific", - "engineering", - "helps", - "provides", - "design", - "deeper", - "rather", - "rationally", + "parallel", "states", - "hydrophobic", - "switches", - "association", - "describe", - "high", + "system", "rationalize", - "ubiquitous", - "known", - "structural", - "variant", - "designs", - "discerned", + "dominate", + "landscape", + "nevertheless", + "describe", + "associated", + "amphipathic", + "analysis", + "example", "one", - "helices", - "accessible", - "novo", - "well", - "different", - "understood", - "dimers", - "antiparallel", - "system", + "association", + "main", + "rather", + "structurally", + "structures", + "deeper", + "de", + "allowed", + "synthetic", "state", + "nature", + "known", + "cases", + "class", + "force", + "coiled", + "high", + "increasingly", "arrangements", - "scaffold", - "inspection", - "navigation", - "protein", - "water", - "various", - "hyperstable", - "formed" + "designs", + "less" ], "release_date":"2019-05-22", "publication":"\"Navigating the Structural Landscape of De Novo alpha-Helical Bundles\", J.Am.Chem.Soc., 141, 8787-8797", @@ -290125,109 +291187,109 @@ ], "subtitle":"Crystal structure of a cc-hex mutant that forms an antiparallel four-helix coiled coil cc-hex*-ll-kgeb", "tags":[ - "antiparallel", + "coiled coil", "tetramer", + "antiparallel", "de novo protein", - "coiled coil", "synthetic", "cc-hex" ], "keywords":[ - "analysis", - "tetramer", - "cases", - "amphipathic", - "us", - "extreme", - "established", - "discriminate", - "peptide", - "example", - "robust", - "hexamers", - "parallel", - "crystal", - "increasingly", - "dominate", - "synthetic", + "dimers", + "engineering", + "driving", + "hydrophobic", + "structural", + "hyperstable", + "resolution", + "number", + "well", + "rationally", + "helps", + "various", + "protein", + "discerned", + "changes", + "fully", + "navigation", "\u03b1", - "structurally", - "allowed", - "leads", - "however", - "mixed", + "ubiquitous", + "novo", + "crystal", + "helices", + "robust", + "water", "alternative", - "coiled", - "de", - "main", - "tetramers", + "antiparallel", "characterized", + "however", + "formed", + "us", + "define", + "accessible", + "specific", + "hexamers", + "trimers", "response", - "less", - "number", - "orientation", - "fully", - "nature", - "relationships", - "structures", - "driving", - "coils", - "solution", - "force", - "biology", "achieved", - "nevertheless", + "tetramers", + "established", + "scaffold", + "mixed", + "coils", + "inspection", + "switches", + "peptide", + "tetramer", + "design", "another", + "provides", + "discriminate", "functional", - "associated", + "biology", + "different", + "leads", + "variant", + "orientation", + "extreme", + "relationships", + "solution", + "understood", "conditions", - "changes", - "resolution", - "class", - "define", - "trimers", - "landscape", - "specific", - "engineering", - "helps", - "provides", - "design", - "deeper", - "rather", - "rationally", + "parallel", "states", - "hydrophobic", - "switches", - "association", - "describe", - "high", + "system", "rationalize", - "ubiquitous", - "known", - "structural", - "variant", - "designs", - "discerned", + "dominate", + "landscape", + "nevertheless", + "describe", + "associated", + "amphipathic", + "analysis", + "example", "one", - "helices", - "accessible", - "novo", - "well", - "different", - "understood", - "dimers", - "antiparallel", - "system", + "association", + "main", + "rather", + "structurally", + "structures", + "deeper", + "de", + "allowed", + "synthetic", "state", + "nature", + "known", + "cases", + "class", + "force", + "coiled", + "high", + "increasingly", "arrangements", - "scaffold", - "inspection", - "navigation", - "protein", - "water", - "various", - "hyperstable", - "formed" + "designs", + "less" ], "release_date":"2019-05-22", "publication":"\"Navigating the Structural Landscape of De Novo alpha-Helical Bundles\", J.Am.Chem.Soc., 141, 8787-8797", @@ -290280,6 +291342,10 @@ "sim":1.0, "partner":"3r3k" }, + { + "sim":1.0, + "partner":"3r48" + }, { "sim":1.0, "partner":"4h8m" @@ -290290,19 +291356,15 @@ }, { "sim":1.0, - "partner":"3r48" - }, - { - "sim":1.0, - "partner":"6q5j" + "partner":"6q5p" }, { "sim":1.0, - "partner":"6q5p" + "partner":"3r46" }, { "sim":1.0, - "partner":"3r46" + "partner":"6q5j" }, { "sim":0.9983999729, @@ -290352,21 +291414,21 @@ "sim":1.0, "partner":"8qaa" }, - { - "sim":0.976000011, - "partner":"5kb0" - }, { "sim":0.9769999981, "partner":"5kb1" }, { - "sim":0.9740999937, - "partner":"7n2z" + "sim":0.9502999783, + "partner":"5eoj" }, { - "sim":0.9534000158, - "partner":"6v5j" + "sim":0.976000011, + "partner":"5kb0" + }, + { + "sim":0.9740999937, + "partner":"7n2z" }, { "sim":0.9754999876, @@ -290382,7 +291444,7 @@ }, { "sim":0.9575999975, - "partner":"6q1w" + "partner":"6osd" }, { "sim":0.9693999887, @@ -290393,52 +291455,52 @@ "partner":"7n2y" }, { - "sim":0.9575999975, - "partner":"6osd" + "sim":1.0, + "partner":"3r4a" }, { - "sim":0.9534000158, - "partner":"6q25" + "sim":0.9566000104, + "partner":"6v50" }, { - "sim":0.9556000233, - "partner":"6v58" + "sim":0.9951999784, + "partner":"6i1j" }, { - "sim":0.9549000263, - "partner":"6v5i" + "sim":0.9955999851, + "partner":"3r4h" }, { "sim":0.9556000233, "partner":"5uxt" }, { - "sim":1.0, - "partner":"3r4a" + "sim":0.9534000158, + "partner":"6v5j" }, { - "sim":0.9545999765, - "partner":"6v4y" + "sim":0.9575999975, + "partner":"6q1w" }, { - "sim":0.9566000104, - "partner":"6v50" + "sim":0.9534000158, + "partner":"6q25" }, { - "sim":0.9566000104, - "partner":"6ovs" + "sim":0.9556000233, + "partner":"6v58" }, { - "sim":0.9951999784, - "partner":"6i1j" + "sim":0.9549000263, + "partner":"6v5i" }, { - "sim":0.9955999851, - "partner":"3r4h" + "sim":0.9545999765, + "partner":"6v4y" }, { - "sim":0.9502999783, - "partner":"5eoj" + "sim":0.9566000104, + "partner":"6ovs" }, { "sim":0.9566000104, @@ -290537,108 +291599,108 @@ ], "subtitle":"Crystal structure of a de novo designed antiparallel four-helix coiled coil apcc-tet", "tags":[ - "antiparallel", + "coiled coil", "tetramer", + "antiparallel", "de novo protein", - "coiled coil", "synthetic" ], "keywords":[ - "analysis", - "tetramer", - "cases", - "amphipathic", - "us", - "extreme", - "established", - "discriminate", - "peptide", - "example", - "robust", - "hexamers", - "parallel", - "crystal", - "increasingly", - "dominate", - "synthetic", + "dimers", + "engineering", + "driving", + "hydrophobic", + "structural", + "hyperstable", + "resolution", + "number", + "well", + "rationally", + "helps", + "various", + "protein", + "discerned", + "changes", + "fully", + "navigation", "\u03b1", - "structurally", - "allowed", - "leads", - "however", - "mixed", + "ubiquitous", + "novo", + "crystal", + "helices", + "robust", + "water", "alternative", - "coiled", - "de", - "main", - "tetramers", + "antiparallel", "characterized", + "however", + "formed", + "us", + "define", + "accessible", + "specific", + "hexamers", + "trimers", "response", - "less", - "number", - "orientation", - "fully", - "nature", - "relationships", - "structures", - "driving", - "coils", - "solution", - "force", - "biology", "achieved", - "nevertheless", + "tetramers", + "established", + "scaffold", + "mixed", + "coils", + "inspection", + "switches", + "peptide", + "tetramer", + "design", "another", + "provides", + "discriminate", "functional", - "associated", + "biology", + "different", + "leads", + "variant", + "orientation", + "extreme", + "relationships", + "solution", + "understood", "conditions", - "changes", - "resolution", - "class", - "define", - "trimers", - "landscape", - "specific", - "engineering", - "helps", - "provides", - "design", - "deeper", - "rather", - "rationally", + "parallel", "states", - "hydrophobic", - "switches", - "association", - "describe", - "high", + "system", "rationalize", - "ubiquitous", - "known", - "structural", - "variant", - "designs", - "discerned", + "dominate", + "landscape", + "nevertheless", + "describe", + "associated", + "amphipathic", + "analysis", + "example", "one", - "helices", - "accessible", - "novo", - "well", - "different", - "understood", - "dimers", - "antiparallel", - "system", + "association", + "main", + "rather", + "structurally", + "structures", + "deeper", + "de", + "allowed", + "synthetic", "state", + "nature", + "known", + "cases", + "class", + "force", + "coiled", + "high", + "increasingly", "arrangements", - "scaffold", - "inspection", - "navigation", - "protein", - "water", - "various", - "hyperstable", - "formed" + "designs", + "less" ], "release_date":"2019-05-22", "publication":"\"Navigating the Structural Landscape of De Novo alpha-Helical Bundles\", J.Am.Chem.Soc., 141, 8787-8797", @@ -290683,6 +291745,10 @@ "sim":1.0, "partner":"6q5n" }, + { + "sim":0.9761999846, + "partner":"6q5o" + }, { "sim":0.9746999741, "partner":"6q5q" @@ -290692,8 +291758,8 @@ "partner":"3r3k" }, { - "sim":0.9761999846, - "partner":"6q5o" + "sim":1.0, + "partner":"4h8m" }, { "sim":1.0, @@ -290705,15 +291771,11 @@ }, { "sim":1.0, - "partner":"3r48" - }, - { - "sim":1.0, - "partner":"4h8m" + "partner":"6q5j" }, { "sim":1.0, - "partner":"6q5j" + "partner":"3r48" }, { "sim":1.0, @@ -290755,6 +291817,10 @@ "sim":1.0, "partner":"8qaa" }, + { + "sim":0.9539999962, + "partner":"5eoj" + }, { "sim":0.9557999969, "partner":"5vte" @@ -290775,10 +291841,6 @@ "sim":1.0, "partner":"4dzl" }, - { - "sim":0.9769999981, - "partner":"5kb0" - }, { "sim":0.9769999981, "partner":"5kb1" @@ -290808,29 +291870,41 @@ "partner":"4dzn" }, { - "sim":0.9562000036, - "partner":"6q1w" + "sim":0.9769999981, + "partner":"5kb0" }, { - "sim":0.9575999975, - "partner":"6osd" + "sim":1.0, + "partner":"4pn8" + }, + { + "sim":0.9663000107, + "partner":"6ego" + }, + { + "sim":0.9743000269, + "partner":"7n2y" }, { "sim":0.9562000036, - "partner":"6u47" + "partner":"6v5j" }, { - "sim":1.0, - "partner":"4pn8" + "sim":0.9562000036, + "partner":"6q1w" }, { - "sim":0.9550999999, - "partner":"6q25" + "sim":0.9575999975, + "partner":"6osd" }, { "sim":0.9548000097, "partner":"6v58" }, + { + "sim":0.9546999931, + "partner":"6v5i" + }, { "sim":0.9531000257, "partner":"5uxt" @@ -290843,29 +291917,17 @@ "sim":0.9552000165, "partner":"6v50" }, - { - "sim":0.9663000107, - "partner":"6ego" - }, - { - "sim":0.9743000269, - "partner":"7n2y" - }, { "sim":0.9562000036, "partner":"6ovs" }, - { - "sim":0.9539999962, - "partner":"5eoj" - }, { "sim":0.9562000036, - "partner":"6v5j" + "partner":"6u47" }, { - "sim":0.9546999931, - "partner":"6v5i" + "sim":0.9550999999, + "partner":"6q25" } ], "struct_thr_sim_natural":[ @@ -290873,13 +291935,13 @@ "sim":1.0, "partner":"4kvt" }, - { - "sim":0.9965000153, - "partner":"4kvu" - }, { "sim":1.0, "partner":"4kvv" + }, + { + "sim":0.9965000153, + "partner":"4kvu" } ], "seq_max_sim_designed":[ @@ -290890,7 +291952,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"6q5r" + "partner":"4h8m" }, "struct_max_sim_natural":{ "sim":1.0, @@ -290952,106 +292014,106 @@ "engineered scaffold protein" ], "keywords":[ - "stefin", - "domain", - "oligomers", - "monomeric", - "specificity", - "indicative", - "chosen", - "scaffolds", - "peptide", - "consequences", - "retained", - "methods", + "dimers", + "engineering", + "molecular", + "ease", + "additional", + "key", "show", - "favoured", + "methods", + "therefore", + "au1", + "affect", "assess", + "symmetrical", + "model", + "protein", + "study", + "readily", "myc", - "therefore", - "structure", - "alternative", - "interaction", + "binding", + "comprising", + "stefin", + "inserted", + "forms", "original", + "two", + "secondary", + "sqt", + "unaltered", + "using", + "epitope", + "simulations", + "alternative", + "engineered", + "problems", + "mechanisms", + "specificity", + "thermodynamically", + "due", + "furthermore", + "effect", + "particularly", + "targets", + "aptamers", + "derived", + "stability", "proteins", - "employed", + "size", "tetramers", - "oligomerisation", + "may", + "scaffold", + "interface", "small", + "peptide", + "design", + "compared", "used", - "interface", - "consideration", - "aptamers", - "particularly", - "furthermore", - "production", - "dynamics", - "alter", - "efficiency", - "symmetrical", - "upon", - "derived", - "solution", - "revealed", - "ease", - "size", - "thermodynamically", - "uncharacterized", "research", - "additional", - "affect", - "compared", - "stability", - "molecular", "loops", "functional", - "associated", - "may", - "inserted", - "simulations", - "engineering", - "swap", - "design", - "model", - "using", - "secondary", - "effect", - "insertion", - "nmr", - "monoclonal", - "key", - "versatility", - "retaining", - "epitope", - "variant", - "3d", - "one", - "study", - "sqt", - "insertions", "comprehensively", "behaviour", - "problems", - "drug", - "unaltered", + "uncharacterized", + "possible", + "domain", "fold", + "variant", + "consequences", + "chosen", + "insertion", + "consideration", + "solution", + "favoured", + "interaction", + "upon", + "retained", + "retaining", "peptides", + "insertions", + "3d", + "oligomerisation", + "associated", + "dynamics", + "production", + "employed", + "revealed", + "one", + "monoclonal", "presentation", - "engineered", - "two", - "due", - "dimers", - "scaffold", - "protein", - "au1", - "targets", - "mechanisms", - "readily", - "comprising", - "antibodies", - "possible", - "binding", - "forms" + "oligomers", + "structure", + "monomeric", + "scaffolds", + "indicative", + "nmr", + "drug", + "alter", + "efficiency", + "versatility", + "swap", + "antibodies" ], "release_date":"2019-07-03", "publication":"\"Studies of the oligomerisation mechanism of a cystatin-based engineered protein scaffold\", Sci Rep, 9, 9067-9067", @@ -291085,10 +292147,6 @@ ], "seq_thr_sim_natural":[ - { - "sim":158.0, - "partner":"3kfq" - }, { "sim":158.0, "partner":"3k9m" @@ -291107,16 +292165,20 @@ }, { "sim":158.0, - "partner":"1dvc" + "partner":"1nb5" }, { "sim":158.0, - "partner":"1nb5" + "partner":"1dvc" }, { "sim":158.0, "partner":"1dvd" }, + { + "sim":158.0, + "partner":"3kfq" + }, { "sim":157.0, "partner":"1cyu" @@ -291157,7 +292219,7 @@ ], "seq_max_sim_natural":{ "sim":158.0, - "partner":"3kfq" + "partner":"3k9m" }, "struct_max_sim_designed":{ "sim":0.4609000087, @@ -291223,64 +292285,64 @@ ], "subtitle":"Crystal structure of pizza6s", "tags":[ - "artificial beta-propeller protein", "computational design", "de novo protein", - "pizza" + "pizza", + "artificial beta-propeller protein" ], "keywords":[ - "keggin", - "results", - "proteins", - "siw12o40", - "larger", + "designed", + "sta", "defined", - "assemblies", - "ceiii", - "inorganic", - "report", - "tew", - "catalysts", - "polyoxometalates", - "complexes", - "h4", - "hybrid", + "symmetry", + "development", "bioinorganic", - "synergistically", - "1", - "designed", - "clusters", - "k11", - "pw11o39", - "different", + "creation", + "complexes", + "clearly", + "polyoxometalates", + "structures", + "computationally", "na6", - "enormous", - "stoichiometries", - "materials", - "tew6o24", - "crystal", - "potential", - "combine", - "blocks", - "tellurotungstic", + "different", "based", - "creation", + "clusters", + "potential", + "siw12o40", + "properties", + "h4", + "report", + "tew", + "results", "symmetrical", - "structures", + "stoichiometries", "protein", - "2", + "k11", "validate", - "development", - "symmetry", - "sta", - "matching", + "blocks", + "proteins", + "tellurotungstic", "solution", - "computationally", - "clearly", + "inorganic", "formation", + "enormous", + "matching", + "2", + "ceiii", + "keggin", "building", - "novel", - "properties" + "tew6o24", + "larger", + "combine", + "pw11o39", + "crystal", + "hybrid", + "assemblies", + "materials", + "synergistically", + "1", + "catalysts", + "novel" ], "release_date":"2020-03-18", "publication":"\"Hybrid assemblies of a symmetric designer protein and polyoxometalates with matching symmetry\", Chem.Commun.(Camb.), 56, 11601-11604", @@ -291313,19 +292375,19 @@ "seq_thr_sim_designed":[ { "sim":503.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":503.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":503.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":503.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":503.0, @@ -291333,15 +292395,15 @@ }, { "sim":503.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":503.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":503.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":498.0, @@ -291349,15 +292411,15 @@ }, { "sim":498.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":498.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":498.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":498.0, @@ -291401,11 +292463,11 @@ }, { "sim":473.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":473.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":473.0, @@ -291413,7 +292475,7 @@ }, { "sim":473.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":467.0, @@ -291441,11 +292503,11 @@ }, { "sim":166.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":166.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":165.0, @@ -291459,11 +292521,11 @@ "seq_thr_sim_natural":[ { "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":340.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":94.0, @@ -291551,11 +292613,11 @@ }, { "sim":51.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":51.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":51.0, @@ -291633,11 +292695,11 @@ ], "seq_max_sim_designed":{ "sim":503.0, - "partner":"6qsh" + "partner":"6rei" }, "seq_max_sim_natural":{ "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.977699995, @@ -291703,70 +292765,70 @@ ], "subtitle":"Crystal structure of pizza6s in the presence of anderson-evans (tew)", "tags":[ - "pom-protein framework", - "anderson-evans", "computational design", + "pom", "de novo protein", - "polyoxometalate-protein framework", + "polyoxometalate", + "anderson-evans", "artificial beta-propeller protein", - "pizza", - "pom", + "polyoxometalate-protein framework", "tew", - "polyoxometalate" + "pom-protein framework", + "pizza" ], "keywords":[ - "keggin", - "results", - "proteins", - "siw12o40", - "larger", + "designed", + "sta", "defined", - "assemblies", - "ceiii", - "inorganic", - "report", - "tew", - "catalysts", - "polyoxometalates", - "complexes", - "h4", - "hybrid", + "symmetry", + "development", "bioinorganic", - "synergistically", - "1", - "designed", - "clusters", - "k11", - "pw11o39", - "different", + "creation", + "complexes", + "clearly", + "polyoxometalates", + "structures", + "computationally", "na6", - "enormous", - "stoichiometries", - "materials", - "tew6o24", - "crystal", - "potential", - "combine", - "blocks", - "tellurotungstic", + "different", "based", - "creation", + "clusters", + "potential", + "siw12o40", + "properties", + "h4", + "report", + "tew", + "results", "symmetrical", - "structures", + "stoichiometries", "protein", - "2", + "k11", "validate", - "development", - "symmetry", - "sta", - "matching", + "blocks", + "proteins", + "tellurotungstic", "solution", - "computationally", - "clearly", + "inorganic", "formation", + "enormous", + "matching", + "2", + "ceiii", + "keggin", "building", - "novel", - "properties" + "tew6o24", + "larger", + "combine", + "pw11o39", + "crystal", + "hybrid", + "assemblies", + "materials", + "synergistically", + "1", + "catalysts", + "novel" ], "release_date":"2020-03-18", "publication":"\"Hybrid assemblies of a symmetric designer protein and polyoxometalates with matching symmetry\", Chem.Commun.(Camb.), 56, 11601-11604", @@ -291799,35 +292861,35 @@ "seq_thr_sim_designed":[ { "sim":503.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":503.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":503.0, - "partner":"7ov7" + "partner":"6reg" }, { "sim":503.0, - "partner":"6rei" + "partner":"6qsf" }, { "sim":503.0, - "partner":"6qsf" + "partner":"6qsg" }, { "sim":503.0, - "partner":"6reh" + "partner":"6qsh" }, { "sim":503.0, - "partner":"6qsg" + "partner":"6qsd" }, { "sim":503.0, - "partner":"6qsd" + "partner":"7ov7" }, { "sim":498.0, @@ -291835,15 +292897,15 @@ }, { "sim":498.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":498.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":498.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":498.0, @@ -291887,11 +292949,11 @@ }, { "sim":473.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":473.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":473.0, @@ -291899,7 +292961,7 @@ }, { "sim":473.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":467.0, @@ -291927,11 +292989,11 @@ }, { "sim":166.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":166.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":165.0, @@ -291945,11 +293007,11 @@ "seq_thr_sim_natural":[ { "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":340.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":94.0, @@ -292037,11 +293099,11 @@ }, { "sim":51.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":51.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":51.0, @@ -292139,11 +293201,11 @@ ], "seq_max_sim_designed":{ "sim":503.0, - "partner":"6qsh" + "partner":"6rei" }, "seq_max_sim_natural":{ "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9890000224, @@ -292209,70 +293271,70 @@ ], "subtitle":"Crystal structure of pizza6s in the presence of keggin (sta)", "tags":[ - "pom-protein framework", "computational design", + "pom", "keggin structure", + "sta", "de novo protein", - "polyoxometalate-protein framework", - "artificial beta-propeller protein", - "pizza", - "pom", "polyoxometalate", - "sta" + "artificial beta-propeller protein", + "polyoxometalate-protein framework", + "pom-protein framework", + "pizza" ], "keywords":[ - "keggin", - "results", - "proteins", - "siw12o40", - "larger", + "designed", + "sta", "defined", - "assemblies", - "ceiii", - "inorganic", - "report", - "tew", - "catalysts", - "polyoxometalates", - "complexes", - "h4", - "hybrid", + "symmetry", + "development", "bioinorganic", - "synergistically", - "1", - "designed", - "clusters", - "k11", - "pw11o39", - "different", + "creation", + "complexes", + "clearly", + "polyoxometalates", + "structures", + "computationally", "na6", - "enormous", - "stoichiometries", - "materials", - "tew6o24", - "crystal", - "potential", - "combine", - "blocks", - "tellurotungstic", + "different", "based", - "creation", + "clusters", + "potential", + "siw12o40", + "properties", + "h4", + "report", + "tew", + "results", "symmetrical", - "structures", + "stoichiometries", "protein", - "2", + "k11", "validate", - "development", - "symmetry", - "sta", - "matching", + "blocks", + "proteins", + "tellurotungstic", "solution", - "computationally", - "clearly", + "inorganic", "formation", + "enormous", + "matching", + "2", + "ceiii", + "keggin", "building", - "novel", - "properties" + "tew6o24", + "larger", + "combine", + "pw11o39", + "crystal", + "hybrid", + "assemblies", + "materials", + "synergistically", + "1", + "catalysts", + "novel" ], "release_date":"2020-03-18", "publication":"\"Hybrid assemblies of a symmetric designer protein and polyoxometalates with matching symmetry\", Chem.Commun.(Camb.), 56, 11601-11604", @@ -292305,27 +293367,27 @@ "seq_thr_sim_designed":[ { "sim":503.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":503.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":503.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":503.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":503.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":503.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":503.0, @@ -292333,7 +293395,7 @@ }, { "sim":503.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":498.0, @@ -292341,15 +293403,15 @@ }, { "sim":498.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":498.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":498.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":498.0, @@ -292393,11 +293455,11 @@ }, { "sim":473.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":473.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":473.0, @@ -292405,7 +293467,7 @@ }, { "sim":473.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":467.0, @@ -292433,11 +293495,11 @@ }, { "sim":166.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":166.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":165.0, @@ -292451,11 +293513,11 @@ "seq_thr_sim_natural":[ { "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":340.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":94.0, @@ -292543,11 +293605,11 @@ }, { "sim":51.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":51.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":51.0, @@ -292621,11 +293683,11 @@ ], "seq_max_sim_designed":{ "sim":503.0, - "partner":"6qsh" + "partner":"6rei" }, "seq_max_sim_natural":{ "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9718000293, @@ -292691,70 +293753,70 @@ ], "subtitle":"Crystal structure of the hybrid bioinorganic complex of pizza6s and keggin (sta)", "tags":[ - "pom-protein framework", "computational design", + "pom", "keggin structure", + "sta", "de novo protein", - "polyoxometalate-protein framework", - "artificial beta-propeller protein", - "pizza", - "pom", "polyoxometalate", - "sta" + "artificial beta-propeller protein", + "polyoxometalate-protein framework", + "pom-protein framework", + "pizza" ], "keywords":[ - "keggin", - "results", - "proteins", - "siw12o40", - "larger", + "designed", + "sta", "defined", - "assemblies", - "ceiii", - "inorganic", - "report", - "tew", - "catalysts", - "polyoxometalates", - "complexes", - "h4", - "hybrid", + "symmetry", + "development", "bioinorganic", - "synergistically", - "1", - "designed", - "clusters", - "k11", - "pw11o39", - "different", + "creation", + "complexes", + "clearly", + "polyoxometalates", + "structures", + "computationally", "na6", - "enormous", - "stoichiometries", - "materials", - "tew6o24", - "crystal", - "potential", - "combine", - "blocks", - "tellurotungstic", + "different", "based", - "creation", + "clusters", + "potential", + "siw12o40", + "properties", + "h4", + "report", + "tew", + "results", "symmetrical", - "structures", + "stoichiometries", "protein", - "2", + "k11", "validate", - "development", - "symmetry", - "sta", - "matching", + "blocks", + "proteins", + "tellurotungstic", "solution", - "computationally", - "clearly", + "inorganic", "formation", + "enormous", + "matching", + "2", + "ceiii", + "keggin", "building", - "novel", - "properties" + "tew6o24", + "larger", + "combine", + "pw11o39", + "crystal", + "hybrid", + "assemblies", + "materials", + "synergistically", + "1", + "catalysts", + "novel" ], "release_date":"2020-03-18", "publication":"\"Hybrid assemblies of a symmetric designer protein and polyoxometalates with matching symmetry\", Chem.Commun.(Camb.), 56, 11601-11604", @@ -292787,19 +293849,19 @@ "seq_thr_sim_designed":[ { "sim":503.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":503.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":503.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":503.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":503.0, @@ -292807,7 +293869,7 @@ }, { "sim":503.0, - "partner":"6reh" + "partner":"6qsh" }, { "sim":503.0, @@ -292815,7 +293877,7 @@ }, { "sim":503.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":498.0, @@ -292823,15 +293885,15 @@ }, { "sim":498.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":498.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":498.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":498.0, @@ -292875,11 +293937,11 @@ }, { "sim":473.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":473.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":473.0, @@ -292887,7 +293949,7 @@ }, { "sim":473.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":467.0, @@ -292915,11 +293977,11 @@ }, { "sim":166.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":166.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":165.0, @@ -292933,11 +293995,11 @@ "seq_thr_sim_natural":[ { "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":340.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":94.0, @@ -293025,11 +294087,11 @@ }, { "sim":51.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":51.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":51.0, @@ -293147,11 +294209,11 @@ ], "seq_max_sim_designed":{ "sim":503.0, - "partner":"6qsh" + "partner":"6rei" }, "seq_max_sim_natural":{ "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9965000153, @@ -293217,69 +294279,69 @@ ], "subtitle":"Crystal structure of the hybrid bioinorganic complex of pizza6s linked by the 1:2 ce-substituted keggin", "tags":[ - "pom-protein framework", - "1:2 ce-substituted keggin", "computational design", + "pom", "de novo protein", - "polyoxometalate-protein framework", + "polyoxometalate", "artificial beta-propeller protein", - "pizza", - "pom", - "polyoxometalate" + "polyoxometalate-protein framework", + "pom-protein framework", + "1:2 ce-substituted keggin", + "pizza" ], "keywords":[ - "keggin", - "results", - "proteins", - "siw12o40", - "larger", + "designed", + "sta", "defined", - "assemblies", - "ceiii", - "inorganic", - "report", - "tew", - "catalysts", - "polyoxometalates", - "complexes", - "h4", - "hybrid", + "symmetry", + "development", "bioinorganic", - "synergistically", - "1", - "designed", - "clusters", - "k11", - "pw11o39", - "different", + "creation", + "complexes", + "clearly", + "polyoxometalates", + "structures", + "computationally", "na6", - "enormous", - "stoichiometries", - "materials", - "tew6o24", - "crystal", - "potential", - "combine", - "blocks", - "tellurotungstic", + "different", "based", - "creation", + "clusters", + "potential", + "siw12o40", + "properties", + "h4", + "report", + "tew", + "results", "symmetrical", - "structures", + "stoichiometries", "protein", - "2", + "k11", "validate", - "development", - "symmetry", - "sta", - "matching", + "blocks", + "proteins", + "tellurotungstic", "solution", - "computationally", - "clearly", + "inorganic", "formation", + "enormous", + "matching", + "2", + "ceiii", + "keggin", "building", - "novel", - "properties" + "tew6o24", + "larger", + "combine", + "pw11o39", + "crystal", + "hybrid", + "assemblies", + "materials", + "synergistically", + "1", + "catalysts", + "novel" ], "release_date":"2020-03-18", "publication":"\"Hybrid assemblies of a symmetric designer protein and polyoxometalates with matching symmetry\", Chem.Commun.(Camb.), 56, 11601-11604", @@ -293312,23 +294374,23 @@ "seq_thr_sim_designed":[ { "sim":503.0, - "partner":"6reg" + "partner":"6rei" }, { "sim":503.0, - "partner":"7ov7" + "partner":"6reh" }, { "sim":503.0, - "partner":"6rei" + "partner":"6qse" }, { "sim":503.0, - "partner":"6qsf" + "partner":"6reg" }, { "sim":503.0, - "partner":"6reh" + "partner":"6qsf" }, { "sim":503.0, @@ -293340,7 +294402,7 @@ }, { "sim":503.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":498.0, @@ -293348,15 +294410,15 @@ }, { "sim":498.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":498.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":498.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":498.0, @@ -293400,11 +294462,11 @@ }, { "sim":473.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":473.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":473.0, @@ -293412,7 +294474,7 @@ }, { "sim":473.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":467.0, @@ -293440,11 +294502,11 @@ }, { "sim":166.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":166.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":165.0, @@ -293458,11 +294520,11 @@ "seq_thr_sim_natural":[ { "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":340.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":94.0, @@ -293550,11 +294612,11 @@ }, { "sim":51.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":51.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":51.0, @@ -293573,11 +294635,11 @@ ], "seq_max_sim_designed":{ "sim":503.0, - "partner":"6reg" + "partner":"6rei" }, "seq_max_sim_natural":{ "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9412999749, @@ -293647,84 +294709,84 @@ ], "subtitle":"Structure of peptide p7, which binds cdc42 and inhibits effector interactions", "tags":[ - "inhibitor", - "cyclic peptide", "de novo protein", - "synthetic peptide" + "cyclic peptide", + "synthetic peptide", + "inhibitor" ], "keywords":[ - "panel", - "engage", - "cdc42", - "arm", - "cancers", - "data", - "gtpases", + "affinity", + "ras", + "invasion", "models", - "solved", - "drives", - "specificity", - "cell", - "suppression", - "aberrant", - "rho", - "family", "signaling", - "drug", - "peptide", + "specificity", + "arm", "gtpase", - "increased", - "discovery", - "peptides", - "literature", - "place", - "biologics", - "demonstrating", - "small", - "growing", - "shown", - "binds", - "add", - "pathways", - "site", - "tightest", - "determined", - "target", - "inhibition", - "addition", - "ras", "show", - "produced", - "nanomolar", - "modulated", - "invasion", - "motility", + "panel", "30", + "modulated", "therapeutics", - "present", - "derived", - "effect", - "nmr", + "aberrant", + "modulating", + "represent", + "biologics", + "rho", "access", - "combat", + "allowed", "interior", + "effect", + "engage", + "motility", "structure", - "modulating", - "sequence", - "proliferation", - "allowed", + "targeting", + "family", + "addition", + "gtpases", + "determined", + "add", + "candidates", + "literature", + "place", + "cyclic", + "target", + "nmr", "maturation", - "represent", - "promising", + "cell", + "derived", + "increased", + "shown", + "suppression", "inhibitors", - "candidates", - "affinity", - "cancer", - "inhibitory", "establishing", + "drug", "binding", - "cyclic", - "targeting" + "drives", + "produced", + "growing", + "site", + "promising", + "sequence", + "small", + "solved", + "peptides", + "discovery", + "present", + "inhibition", + "data", + "cancers", + "binds", + "cdc42", + "tightest", + "combat", + "nanomolar", + "pathways", + "proliferation", + "demonstrating", + "cancer", + "peptide", + "inhibitory" ], "release_date":"2020-01-29", "publication":"\"The discovery and maturation of peptide biologics targeting the small G-protein Cdc42: A bioblockade for Ras-driven signaling\", J.Biol.Chem., 295, 2866-2884", @@ -293838,83 +294900,83 @@ ], "subtitle":"8-bladed beta-propeller formed by two 4-bladed fragments", "tags":[ - "fragment amplification", - "protein evolution", "protein design", "unknown function", + "fragment amplification", + "protein evolution", "repeat protein" ], "keywords":[ - "depending", - "blades", - "diverse", - "always", - "toroids", - "data", - "produces", - "evolution", - "called", - "chain", + "wd40", + "repeats", + "whether", "amplified", - "proteins", - "respectively", + "dimers", + "flexibility", + "blades", + "twelve", "investigated", - "propellers", - "process", - "stable", + "structural", + "show", + "chain", + "diverse", + "structurally", + "therefore", + "structures", "single", - "tetramers", - "four", - "whether", - "twelve", - "hypothesis", - "almost", - "fold", - "trimers", - "yielded", - "fragments", "supersecondary", - "found", - "provide", - "flexibility", - "two", - "fully", - "dimers", - "highlighting", - "wd40", - "evolve", - "six", + "respectively", "include", - "blocks", + "fragments", "amplification", - "sequentially", - "show", - "support", + "almost", + "nascent", "arise", - "arranged", - "polypeptide", - "continuously", - "structures", - "derived", - "therefore", - "structure", "three", - "block", - "repeats", - "structurally", + "structure", + "called", + "fold", + "within", "nine", + "polypeptide", + "block", + "new", + "trimers", + "provide", + "propellers", + "derived", + "six", + "depending", + "blocks", + "produces", + "proteins", + "process", + "fully", "size", - "within", + "yielded", "blade", - "versatility", - "nascent", + "arranged", + "tetramers", + "highlighting", + "support", + "sequentially", "building", - "novel", + "found", + "two", + "evolution", + "data", + "toroids", + "evolve", + "continuously", + "stable", + "four", + "always", + "versatility", "element", - "structural", - "five", - "new", - "inherent" + "hypothesis", + "inherent", + "novel", + "five" ], "release_date":"2019-11-13", "publication":"\"Structural diversity of oligomeric beta-propellers with different numbers of identical blades\", Elife, 8", @@ -294029,83 +295091,83 @@ "subtitle":"9-bladed beta-propeller formed by three 3-bladed fragments", "tags":[ "wd40", - "fragment amplification", - "protein evolution", "protein design", "unknown function", + "fragment amplification", + "protein evolution", "repeat protein" ], "keywords":[ - "depending", - "blades", - "diverse", - "always", - "toroids", - "data", - "produces", - "evolution", - "called", - "chain", + "wd40", + "repeats", + "whether", "amplified", - "proteins", - "respectively", + "dimers", + "flexibility", + "blades", + "twelve", "investigated", - "propellers", - "process", - "stable", + "structural", + "show", + "chain", + "diverse", + "structurally", + "therefore", + "structures", "single", - "tetramers", - "four", - "whether", - "twelve", - "hypothesis", - "almost", - "fold", - "trimers", - "yielded", - "fragments", "supersecondary", - "found", - "provide", - "flexibility", - "two", - "fully", - "dimers", - "highlighting", - "wd40", - "evolve", - "six", + "respectively", "include", - "blocks", + "fragments", "amplification", - "sequentially", - "show", - "support", + "almost", + "nascent", "arise", - "arranged", - "polypeptide", - "continuously", - "structures", - "derived", - "therefore", - "structure", "three", - "block", - "repeats", - "structurally", + "structure", + "called", + "fold", + "within", "nine", + "polypeptide", + "block", + "new", + "trimers", + "provide", + "propellers", + "derived", + "six", + "depending", + "blocks", + "produces", + "proteins", + "process", + "fully", "size", - "within", + "yielded", "blade", - "versatility", - "nascent", + "arranged", + "tetramers", + "highlighting", + "support", + "sequentially", "building", - "novel", + "found", + "two", + "evolution", + "data", + "toroids", + "evolve", + "continuously", + "stable", + "four", + "always", + "versatility", "element", - "structural", - "five", - "new", - "inherent" + "hypothesis", + "inherent", + "novel", + "five" ], "release_date":"2019-11-13", "publication":"\"Structural diversity of oligomeric beta-propellers with different numbers of identical blades\", Elife, 8", @@ -294158,19 +295220,19 @@ }, { "sim":97.0, - "partner":"6g6n" + "partner":"6g6m" }, { "sim":97.0, - "partner":"6y7p" + "partner":"6y7n" }, { "sim":97.0, - "partner":"6y7n" + "partner":"6g6n" }, { "sim":97.0, - "partner":"6g6m" + "partner":"6y7p" } ], "seq_thr_sim_natural":[ @@ -294206,6 +295268,10 @@ "sim":103.0, "partner":"4cy5" }, + { + "sim":103.0, + "partner":"8rl2" + }, { "sim":102.0, "partner":"6dy7" @@ -294222,21 +295288,13 @@ "sim":102.0, "partner":"2g99" }, - { - "sim":102.0, - "partner":"5vfc" - }, { "sim":102.0, "partner":"2g9a" }, { "sim":102.0, - "partner":"2h6k" - }, - { - "sim":102.0, - "partner":"5eap" + "partner":"5vfc" }, { "sim":102.0, @@ -294316,27 +295374,27 @@ }, { "sim":102.0, - "partner":"2h9n" + "partner":"2h6k" }, { "sim":102.0, - "partner":"6e1y" + "partner":"5eap" }, { "sim":102.0, - "partner":"6e1z" + "partner":"6dai" }, { "sim":102.0, - "partner":"6dai" + "partner":"6e1z" }, { "sim":102.0, - "partner":"4gm8" + "partner":"6dak" }, { "sim":102.0, - "partner":"6dak" + "partner":"4gm8" }, { "sim":102.0, @@ -294360,11 +295418,11 @@ }, { "sim":102.0, - "partner":"4gmb" + "partner":"6dar" }, { "sim":102.0, - "partner":"6dar" + "partner":"4gmb" }, { "sim":102.0, @@ -294382,6 +295440,14 @@ "sim":102.0, "partner":"2h9m" }, + { + "sim":102.0, + "partner":"2h9n" + }, + { + "sim":102.0, + "partner":"6e1y" + }, { "sim":102.0, "partner":"5sxm" @@ -294458,10 +295524,6 @@ "sim":102.0, "partner":"2h9l" }, - { - "sim":102.0, - "partner":"2xl3" - }, { "sim":102.0, "partner":"6kiw" @@ -294486,6 +295548,10 @@ "sim":102.0, "partner":"6kix" }, + { + "sim":102.0, + "partner":"2xl3" + }, { "sim":102.0, "partner":"2gnq" @@ -294516,15 +295582,15 @@ }, { "sim":96.0, - "partner":"3jct" + "partner":"6ft6" }, { "sim":96.0, - "partner":"5jcs" + "partner":"3jct" }, { "sim":96.0, - "partner":"6ft6" + "partner":"5jcs" }, { "sim":96.0, @@ -294664,15 +295730,15 @@ }, { "sim":82.0, - "partner":"5xjc" + "partner":"6icz" }, { "sim":82.0, - "partner":"5z57" + "partner":"5xjc" }, { "sim":82.0, - "partner":"6icz" + "partner":"5z57" }, { "sim":82.0, @@ -294700,23 +295766,23 @@ }, { "sim":81.0, - "partner":"8ut0" + "partner":"8uti" }, { "sim":81.0, - "partner":"8qie" + "partner":"8ut0" }, { "sim":81.0, - "partner":"8uti" + "partner":"8qie" }, { "sim":81.0, - "partner":"6i7o" + "partner":"4v7h" }, { "sim":81.0, - "partner":"4v7h" + "partner":"6i7o" }, { "sim":81.0, @@ -294728,35 +295794,27 @@ }, { "sim":81.0, - "partner":"4u4q" - }, - { - "sim":81.0, - "partner":"5obm" - }, - { - "sim":81.0, - "partner":"4u4r" + "partner":"4u6f" }, { "sim":81.0, - "partner":"5tgm" + "partner":"5dc3" }, { "sim":81.0, - "partner":"4u6f" + "partner":"5lyb" }, { "sim":81.0, - "partner":"5dc3" + "partner":"4uer" }, { "sim":81.0, - "partner":"5lyb" + "partner":"6gqv" }, { "sim":81.0, - "partner":"4uer" + "partner":"6q8y" }, { "sim":81.0, @@ -294768,11 +295826,7 @@ }, { "sim":81.0, - "partner":"6gqv" - }, - { - "sim":81.0, - "partner":"6q8y" + "partner":"5tgm" }, { "sim":81.0, @@ -294794,6 +295848,10 @@ "sim":81.0, "partner":"5ndv" }, + { + "sim":81.0, + "partner":"6gq1" + }, { "sim":81.0, "partner":"5ndw" @@ -294808,7 +295866,7 @@ }, { "sim":81.0, - "partner":"6gq1" + "partner":"6gqb" }, { "sim":81.0, @@ -294822,10 +295880,6 @@ "sim":81.0, "partner":"5dgv" }, - { - "sim":81.0, - "partner":"6gqb" - }, { "sim":81.0, "partner":"4u50" @@ -294836,15 +295890,15 @@ }, { "sim":81.0, - "partner":"5tbw" + "partner":"6s47" }, { "sim":81.0, - "partner":"4u51" + "partner":"5tbw" }, { "sim":81.0, - "partner":"6s47" + "partner":"4u51" }, { "sim":81.0, @@ -294896,15 +295950,15 @@ }, { "sim":81.0, - "partner":"3j6y" + "partner":"4u4q" }, { "sim":81.0, - "partner":"4v8y" + "partner":"5obm" }, { "sim":81.0, - "partner":"5juo" + "partner":"4u4r" }, { "sim":81.0, @@ -294920,7 +295974,11 @@ }, { "sim":81.0, - "partner":"8p4v" + "partner":"6rbe" + }, + { + "sim":81.0, + "partner":"3j78" }, { "sim":81.0, @@ -294928,27 +295986,27 @@ }, { "sim":81.0, - "partner":"8t3a" + "partner":"3rfg" }, { "sim":81.0, - "partner":"6rbe" + "partner":"5juu" }, { "sim":81.0, - "partner":"8t30" + "partner":"8t3a" }, { "sim":81.0, - "partner":"3j78" + "partner":"8t30" }, { "sim":81.0, - "partner":"3rfg" + "partner":"3j6x" }, { "sim":81.0, - "partner":"5juu" + "partner":"3rfh" }, { "sim":81.0, @@ -294956,23 +296014,23 @@ }, { "sim":81.0, - "partner":"3j6x" + "partner":"4v88" }, { "sim":81.0, - "partner":"3rfh" + "partner":"8p4v" }, { "sim":81.0, - "partner":"8t3e" + "partner":"4v7r" }, { "sim":81.0, - "partner":"4v88" + "partner":"6hhq" }, { "sim":81.0, - "partner":"4v7r" + "partner":"8t3e" }, { "sim":81.0, @@ -294982,21 +296040,17 @@ "sim":81.0, "partner":"5jup" }, - { - "sim":81.0, - "partner":"6hhq" - }, { "sim":81.0, "partner":"3frx" }, { "sim":81.0, - "partner":"8p9a" + "partner":"4v8z" }, { "sim":81.0, - "partner":"4v8z" + "partner":"3j77" }, { "sim":81.0, @@ -295004,11 +296058,11 @@ }, { "sim":81.0, - "partner":"3j77" + "partner":"5jut" }, { "sim":81.0, - "partner":"5jut" + "partner":"6fai" }, { "sim":81.0, @@ -295016,12 +296070,24 @@ }, { "sim":81.0, - "partner":"6fai" + "partner":"8p9a" + }, + { + "sim":81.0, + "partner":"3j6y" + }, + { + "sim":81.0, + "partner":"4v8y" }, { "sim":81.0, "partner":"8t3b" }, + { + "sim":81.0, + "partner":"5juo" + }, { "sim":81.0, "partner":"8t3d" @@ -295038,10 +296104,6 @@ "sim":80.0, "partner":"4j8g" }, - { - "sim":79.0, - "partner":"6ole" - }, { "sim":79.0, "partner":"6om7" @@ -295060,20 +296122,12 @@ }, { "sim":79.0, - "partner":"6fec" - }, - { - "sim":79.0, - "partner":"6mtb" + "partner":"6ole" }, { "sim":79.0, "partner":"3jaj" }, - { - "sim":79.0, - "partner":"8ukb" - }, { "sim":79.0, "partner":"6r6g" @@ -295084,11 +296138,11 @@ }, { "sim":79.0, - "partner":"3jai" + "partner":"6r6p" }, { "sim":79.0, - "partner":"6r6p" + "partner":"3jai" }, { "sim":79.0, @@ -295100,12 +296154,16 @@ }, { "sim":79.0, - "partner":"3jah" + "partner":"8ukb" }, { "sim":79.0, "partner":"6mtc" }, + { + "sim":79.0, + "partner":"3jah" + }, { "sim":79.0, "partner":"6r5q" @@ -295128,7 +296186,11 @@ }, { "sim":79.0, - "partner":"6olz" + "partner":"6fec" + }, + { + "sim":79.0, + "partner":"6mtb" }, { "sim":79.0, @@ -295148,35 +296210,27 @@ }, { "sim":79.0, - "partner":"5oa3" - }, - { - "sim":79.0, - "partner":"5a2q" - }, - { - "sim":79.0, - "partner":"5lzv" + "partner":"6olz" }, { "sim":79.0, - "partner":"4kzx" + "partner":"5oa3" }, { "sim":79.0, - "partner":"6ip6" + "partner":"5a2q" }, { "sim":79.0, - "partner":"6p5n" + "partner":"4ujd" }, { "sim":79.0, - "partner":"4ujd" + "partner":"4uje" }, { "sim":79.0, - "partner":"4uje" + "partner":"6p5j" }, { "sim":79.0, @@ -295196,11 +296250,11 @@ }, { "sim":79.0, - "partner":"6p5j" + "partner":"6hcf" }, { "sim":79.0, - "partner":"6hcf" + "partner":"6p5k" }, { "sim":79.0, @@ -295216,7 +296270,7 @@ }, { "sim":79.0, - "partner":"6p5k" + "partner":"6hcm" }, { "sim":79.0, @@ -295224,7 +296278,7 @@ }, { "sim":79.0, - "partner":"6hcm" + "partner":"6ip5" }, { "sim":79.0, @@ -295232,19 +296286,19 @@ }, { "sim":79.0, - "partner":"5lzx" + "partner":"6g18" }, { "sim":79.0, - "partner":"6ip5" + "partner":"5lzx" }, { "sim":79.0, - "partner":"8vft" + "partner":"6g51" }, { "sim":79.0, - "partner":"6g18" + "partner":"6hcq" }, { "sim":79.0, @@ -295256,11 +296310,11 @@ }, { "sim":79.0, - "partner":"6g51" + "partner":"6p5i" }, { "sim":79.0, - "partner":"6hcq" + "partner":"8vft" }, { "sim":79.0, @@ -295268,47 +296322,47 @@ }, { "sim":79.0, - "partner":"5lzt" + "partner":"6d90" }, { "sim":79.0, - "partner":"6p5i" + "partner":"6hcj" }, { "sim":79.0, - "partner":"6d90" + "partner":"6ip8" }, { "sim":79.0, - "partner":"6hcj" + "partner":"5lzt" }, { "sim":79.0, - "partner":"6ip8" + "partner":"6d9j" }, { "sim":79.0, - "partner":"4d61" + "partner":"6p4g" }, { "sim":79.0, - "partner":"5lzw" + "partner":"4d61" }, { "sim":79.0, - "partner":"5t2c" + "partner":"6g5h" }, { "sim":79.0, - "partner":"6d9j" + "partner":"5lzw" }, { "sim":79.0, - "partner":"6p4g" + "partner":"5t2c" }, { "sim":79.0, - "partner":"6g5h" + "partner":"6g5i" }, { "sim":79.0, @@ -295316,11 +296370,11 @@ }, { "sim":79.0, - "partner":"6g5i" + "partner":"4d5l" }, { "sim":79.0, - "partner":"4d5l" + "partner":"6p4h" }, { "sim":79.0, @@ -295328,7 +296382,7 @@ }, { "sim":79.0, - "partner":"6p4h" + "partner":"6g53" }, { "sim":79.0, @@ -295340,7 +296394,19 @@ }, { "sim":79.0, - "partner":"6g53" + "partner":"6ip6" + }, + { + "sim":79.0, + "partner":"6p5n" + }, + { + "sim":79.0, + "partner":"5lzv" + }, + { + "sim":79.0, + "partner":"4kzx" }, { "sim":79.0, @@ -295352,11 +296418,11 @@ }, { "sim":79.0, - "partner":"4v5o" + "partner":"4bts" }, { "sim":79.0, - "partner":"4bts" + "partner":"4v5o" }, { "sim":79.0, @@ -295404,11 +296470,11 @@ }, { "sim":78.0, - "partner":"5oql" + "partner":"6rxz" }, { "sim":78.0, - "partner":"6rxz" + "partner":"5oql" }, { "sim":77.0, @@ -295496,31 +296562,31 @@ }, { "sim":75.0, - "partner":"3jam" + "partner":"6fyx" }, { "sim":75.0, - "partner":"3jap" + "partner":"3j80" }, { "sim":75.0, - "partner":"6fyy" + "partner":"3j81" }, { "sim":75.0, - "partner":"3j80" + "partner":"8s8k" }, { "sim":75.0, - "partner":"6fyx" + "partner":"3jam" }, { "sim":75.0, - "partner":"3j81" + "partner":"3jap" }, { "sim":75.0, - "partner":"8s8k" + "partner":"6fyy" }, { "sim":75.0, @@ -295552,11 +296618,11 @@ }, { "sim":74.0, - "partner":"5wsg" + "partner":"6j6q" }, { "sim":74.0, - "partner":"6j6q" + "partner":"5wsg" }, { "sim":74.0, @@ -295570,6 +296636,10 @@ "sim":74.0, "partner":"5y88" }, + { + "sim":74.0, + "partner":"6j6g" + }, { "sim":74.0, "partner":"5gm6" @@ -295580,7 +296650,7 @@ }, { "sim":74.0, - "partner":"6j6g" + "partner":"6j6n" }, { "sim":74.0, @@ -295588,11 +296658,11 @@ }, { "sim":74.0, - "partner":"6j6n" + "partner":"5lqw" }, { "sim":74.0, - "partner":"5lqw" + "partner":"6j6h" }, { "sim":74.0, @@ -295602,10 +296672,6 @@ "sim":74.0, "partner":"5ylz" }, - { - "sim":74.0, - "partner":"6j6h" - }, { "sim":74.0, "partner":"6q8i" @@ -295638,10 +296704,6 @@ "sim":70.0, "partner":"6eoj" }, - { - "sim":70.0, - "partner":"5nzv" - }, { "sim":70.0, "partner":"5nzt" @@ -295678,6 +296740,10 @@ "sim":70.0, "partner":"5a1w" }, + { + "sim":70.0, + "partner":"5nzv" + }, { "sim":70.0, "partner":"5wve" @@ -295704,11 +296770,11 @@ }, { "sim":69.0, - "partner":"1pev" + "partner":"1nr0" }, { "sim":69.0, - "partner":"1nr0" + "partner":"1pev" }, { "sim":67.0, @@ -295762,10 +296828,6 @@ "sim":66.0, "partner":"5nuv" }, - { - "sim":65.0, - "partner":"6m90" - }, { "sim":65.0, "partner":"6m91" @@ -295782,6 +296844,10 @@ "sim":65.0, "partner":"6m94" }, + { + "sim":65.0, + "partner":"6m90" + }, { "sim":65.0, "partner":"1p22" @@ -295806,14 +296872,6 @@ "sim":64.0, "partner":"6s1l" }, - { - "sim":64.0, - "partner":"5m5g" - }, - { - "sim":64.0, - "partner":"5wfd" - }, { "sim":64.0, "partner":"5bjs" @@ -295846,6 +296904,14 @@ "sim":64.0, "partner":"5wfc" }, + { + "sim":64.0, + "partner":"5m5g" + }, + { + "sim":64.0, + "partner":"5wfd" + }, { "sim":64.0, "partner":"6jp6" @@ -295920,27 +296986,27 @@ }, { "sim":59.0, - "partner":"5khr" + "partner":"6q6h" }, { "sim":59.0, - "partner":"6f0x" + "partner":"6q6g" }, { "sim":59.0, - "partner":"6q6h" + "partner":"5khu" }, { "sim":59.0, - "partner":"5khu" + "partner":"5g04" }, { "sim":59.0, - "partner":"6q6g" + "partner":"6f0x" }, { "sim":59.0, - "partner":"5g04" + "partner":"5khr" }, { "sim":58.0, @@ -295970,14 +297036,6 @@ "sim":57.0, "partner":"4bzj" }, - { - "sim":57.0, - "partner":"3mzk" - }, - { - "sim":57.0, - "partner":"4xmm" - }, { "sim":57.0, "partner":"3mzl" @@ -296008,23 +297066,23 @@ }, { "sim":57.0, - "partner":"3bg1" + "partner":"3mzk" }, { "sim":57.0, - "partner":"3bg0" + "partner":"4xmm" }, { "sim":57.0, - "partner":"5a9q" + "partner":"3bg1" }, { "sim":57.0, - "partner":"5flc" + "partner":"3bg0" }, { "sim":57.0, - "partner":"6sb0" + "partner":"5a9q" }, { "sim":57.0, @@ -296072,12 +297130,20 @@ }, { "sim":57.0, - "partner":"5wbu" + "partner":"6sb0" + }, + { + "sim":57.0, + "partner":"5flc" }, { "sim":57.0, "partner":"5wby" }, + { + "sim":57.0, + "partner":"5wbu" + }, { "sim":57.0, "partner":"3jrp" @@ -296100,11 +297166,11 @@ }, { "sim":55.0, - "partner":"5m2n" + "partner":"6qk7" }, { "sim":55.0, - "partner":"6qk7" + "partner":"5m2n" }, { "sim":55.0, @@ -296150,10 +297216,6 @@ "sim":51.0, "partner":"3ewe" }, - { - "sim":51.0, - "partner":"3f3g" - }, { "sim":51.0, "partner":"3f3p" @@ -296164,7 +297226,7 @@ }, { "sim":51.0, - "partner":"2aq5" + "partner":"3f3g" }, { "sim":51.0, @@ -296172,7 +297234,7 @@ }, { "sim":51.0, - "partner":"2xu7" + "partner":"2aq5" }, { "sim":51.0, @@ -296180,12 +297242,16 @@ }, { "sim":51.0, - "partner":"5fxy" + "partner":"8vml" }, { "sim":51.0, "partner":"6c24" }, + { + "sim":51.0, + "partner":"5fxy" + }, { "sim":51.0, "partner":"4r7a" @@ -296194,10 +297260,18 @@ "sim":51.0, "partner":"4pby" }, + { + "sim":51.0, + "partner":"8vmi" + }, { "sim":51.0, "partner":"4pbz" }, + { + "sim":51.0, + "partner":"8vnv" + }, { "sim":51.0, "partner":"4pc0" @@ -296206,10 +297280,18 @@ "sim":51.0, "partner":"6c23" }, + { + "sim":51.0, + "partner":"8vnz" + }, { "sim":51.0, "partner":"3gfc" }, + { + "sim":51.0, + "partner":"2xu7" + }, { "sim":51.0, "partner":"6bw3" @@ -296240,11 +297322,11 @@ }, { "sim":51.0, - "partner":"5xxq" + "partner":"5y1u" }, { "sim":51.0, - "partner":"5y1u" + "partner":"5xxq" }, { "sim":51.0, @@ -296342,83 +297424,83 @@ "subtitle":"Asymmetric antiparallel assembly of two 5-bladed beta-propeller fragments", "tags":[ "wd40", - "fragment amplification", - "protein evolution", "protein design", "unknown function", + "fragment amplification", + "protein evolution", "repeat protein" ], "keywords":[ - "depending", - "blades", - "diverse", - "always", - "toroids", - "data", - "produces", - "evolution", - "called", - "chain", + "wd40", + "repeats", + "whether", "amplified", - "proteins", - "respectively", + "dimers", + "flexibility", + "blades", + "twelve", "investigated", - "propellers", - "process", - "stable", + "structural", + "show", + "chain", + "diverse", + "structurally", + "therefore", + "structures", "single", - "tetramers", - "four", - "whether", - "twelve", - "hypothesis", - "almost", - "fold", - "trimers", - "yielded", - "fragments", "supersecondary", - "found", - "provide", - "flexibility", - "two", - "fully", - "dimers", - "highlighting", - "wd40", - "evolve", - "six", + "respectively", "include", - "blocks", + "fragments", "amplification", - "sequentially", - "show", - "support", + "almost", + "nascent", "arise", - "arranged", - "polypeptide", - "continuously", - "structures", - "derived", - "therefore", - "structure", "three", - "block", - "repeats", - "structurally", + "structure", + "called", + "fold", + "within", "nine", + "polypeptide", + "block", + "new", + "trimers", + "provide", + "propellers", + "derived", + "six", + "depending", + "blocks", + "produces", + "proteins", + "process", + "fully", "size", - "within", + "yielded", "blade", - "versatility", - "nascent", + "arranged", + "tetramers", + "highlighting", + "support", + "sequentially", "building", - "novel", + "found", + "two", + "evolution", + "data", + "toroids", + "evolve", + "continuously", + "stable", + "four", + "always", + "versatility", "element", - "structural", - "five", - "new", - "inherent" + "hypothesis", + "inherent", + "novel", + "five" ], "release_date":"2019-11-13", "publication":"\"Structural diversity of oligomeric beta-propellers with different numbers of identical blades\", Elife, 8", @@ -296520,57 +297602,57 @@ ], "subtitle":"Crystal structure of pizza6-s with zn2+", "tags":[ - "metalloprotein", "computational design", - "zinc", + "metalloprotein", "de novo protein", "artificial beta-propeller protein", - "pizza" + "pizza", + "zinc" ], "keywords":[ "supramolecular", - "reported", - "acetate", - "pizza6", - "hydrolase", "chemistry", - "studies", - "hydrolysis", - "values", + "mutagenesis", + "triad", + "dependent", "investigated", - "complexes", - "highest", - "enzymes", - "catalytic", - "matched", - "artificial", + "histidine", + "additional", "bioinorganic", + "highest", + "metalloenzymes", + "complexes", "well", - "generated", - "mutant", + "hydrolysis", + "previously", + "based", + "potential", "residues", + "symmetrical", + "matched", + "protein", + "pizza6", + "artificial", + "hydrolase", + "enzymes", + "dyad", "highly", + "reported", + "generated", "found", + "catalytic", + "acetate", + "developed", + "studies", + "utilised", "butyrate", - "materials", - "potential", - "triad", - "crystallisation", - "based", + "mutant", "mechanism", - "utilised", - "forming", - "mutagenesis", - "symmetrical", - "protein", - "dependent", + "materials", "kcat", - "histidine", - "additional", - "metalloenzymes", - "developed", - "dyad", - "previously" + "forming", + "values", + "crystallisation" ], "release_date":"2019-07-31", "publication":"\"Artificial beta-propeller protein-based hydrolases\", Chem.Commun.(Camb.), 55, 8880-8883", @@ -296603,15 +297685,15 @@ "seq_thr_sim_designed":[ { "sim":503.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":503.0, - "partner":"7ov7" + "partner":"6reh" }, { "sim":503.0, - "partner":"6rei" + "partner":"6qse" }, { "sim":503.0, @@ -296619,11 +297701,11 @@ }, { "sim":503.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":503.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":503.0, @@ -296631,7 +297713,7 @@ }, { "sim":503.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":498.0, @@ -296639,15 +297721,15 @@ }, { "sim":498.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":498.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":498.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":498.0, @@ -296691,11 +297773,11 @@ }, { "sim":473.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":473.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":473.0, @@ -296703,7 +297785,7 @@ }, { "sim":473.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":467.0, @@ -296731,11 +297813,11 @@ }, { "sim":166.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":166.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":165.0, @@ -296749,11 +297831,11 @@ "seq_thr_sim_natural":[ { "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":340.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":94.0, @@ -296833,11 +297915,11 @@ }, { "sim":51.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":51.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":51.0, @@ -296939,11 +298021,11 @@ ], "seq_max_sim_designed":{ "sim":503.0, - "partner":"6qsh" + "partner":"6rei" }, "seq_max_sim_natural":{ "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9947000146, @@ -297001,57 +298083,57 @@ ], "subtitle":"Crystal structure of pizza6-s with cu2+", "tags":[ - "metalloprotein", "computational design", + "metalloprotein", + "copper", "de novo protein", "artificial beta-propeller protein", - "pizza", - "copper" + "pizza" ], "keywords":[ "supramolecular", - "reported", - "acetate", - "pizza6", - "hydrolase", "chemistry", - "studies", - "hydrolysis", - "values", + "mutagenesis", + "triad", + "dependent", "investigated", - "complexes", - "highest", - "enzymes", - "catalytic", - "matched", - "artificial", + "histidine", + "additional", "bioinorganic", + "highest", + "metalloenzymes", + "complexes", "well", - "generated", - "mutant", + "hydrolysis", + "previously", + "based", + "potential", "residues", + "symmetrical", + "matched", + "protein", + "pizza6", + "artificial", + "hydrolase", + "enzymes", + "dyad", "highly", + "reported", + "generated", "found", + "catalytic", + "acetate", + "developed", + "studies", + "utilised", "butyrate", - "materials", - "potential", - "triad", - "crystallisation", - "based", + "mutant", "mechanism", - "utilised", - "forming", - "mutagenesis", - "symmetrical", - "protein", - "dependent", + "materials", "kcat", - "histidine", - "additional", - "metalloenzymes", - "developed", - "dyad", - "previously" + "forming", + "values", + "crystallisation" ], "release_date":"2019-07-31", "publication":"\"Artificial beta-propeller protein-based hydrolases\", Chem.Commun.(Camb.), 55, 8880-8883", @@ -297084,27 +298166,27 @@ "seq_thr_sim_designed":[ { "sim":503.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":503.0, - "partner":"6reg" + "partner":"6qse" }, { "sim":503.0, - "partner":"7ov7" + "partner":"6reg" }, { "sim":503.0, - "partner":"6rei" + "partner":"6qsf" }, { "sim":503.0, - "partner":"6qsf" + "partner":"6qsg" }, { "sim":503.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":503.0, @@ -297112,7 +298194,7 @@ }, { "sim":503.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":498.0, @@ -297120,15 +298202,15 @@ }, { "sim":498.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":498.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":498.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":498.0, @@ -297172,11 +298254,11 @@ }, { "sim":473.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":473.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":473.0, @@ -297184,7 +298266,7 @@ }, { "sim":473.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":467.0, @@ -297212,11 +298294,11 @@ }, { "sim":166.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":166.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":165.0, @@ -297230,11 +298312,11 @@ "seq_thr_sim_natural":[ { "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":340.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":94.0, @@ -297314,11 +298396,11 @@ }, { "sim":51.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":51.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":51.0, @@ -297420,11 +298502,11 @@ ], "seq_max_sim_designed":{ "sim":503.0, - "partner":"6qsh" + "partner":"6rei" }, "seq_max_sim_natural":{ "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9862999916, @@ -297482,11 +298564,11 @@ ], "subtitle":"Crystal structure of pizza6-s with cd2+", "tags":[ - "cadmium", - "metalloprotein", "computational design", + "metalloprotein", "de novo protein", "artificial beta-propeller protein", + "cadmium", "pizza" ], "keywords":[ @@ -297524,15 +298606,15 @@ "seq_thr_sim_designed":[ { "sim":503.0, - "partner":"6qsh" + "partner":"6reh" }, { "sim":503.0, - "partner":"6reg" + "partner":"6qse" }, { "sim":503.0, - "partner":"7ov7" + "partner":"6reg" }, { "sim":503.0, @@ -297540,11 +298622,11 @@ }, { "sim":503.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":503.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":503.0, @@ -297552,7 +298634,7 @@ }, { "sim":503.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":498.0, @@ -297560,15 +298642,15 @@ }, { "sim":498.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":498.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":498.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":498.0, @@ -297612,11 +298694,11 @@ }, { "sim":473.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":473.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":473.0, @@ -297624,7 +298706,7 @@ }, { "sim":473.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":467.0, @@ -297652,11 +298734,11 @@ }, { "sim":166.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":166.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":165.0, @@ -297670,11 +298752,11 @@ "seq_thr_sim_natural":[ { "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":340.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":94.0, @@ -297762,11 +298844,11 @@ }, { "sim":51.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":51.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":51.0, @@ -297868,11 +298950,11 @@ ], "seq_max_sim_designed":{ "sim":503.0, - "partner":"6qsh" + "partner":"6reh" }, "seq_max_sim_natural":{ "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9937000275, @@ -297930,57 +299012,57 @@ ], "subtitle":"Crystal structure of pizza6-sh with zn2+", "tags":[ - "metalloprotein", "computational design", - "zinc", + "metalloprotein", "de novo protein", "artificial beta-propeller protein", - "pizza" + "pizza", + "zinc" ], "keywords":[ "supramolecular", - "reported", - "acetate", - "pizza6", - "hydrolase", "chemistry", - "studies", - "hydrolysis", - "values", + "mutagenesis", + "triad", + "dependent", "investigated", - "complexes", - "highest", - "enzymes", - "catalytic", - "matched", - "artificial", + "histidine", + "additional", "bioinorganic", + "highest", + "metalloenzymes", + "complexes", "well", - "generated", - "mutant", + "hydrolysis", + "previously", + "based", + "potential", "residues", + "symmetrical", + "matched", + "protein", + "pizza6", + "artificial", + "hydrolase", + "enzymes", + "dyad", "highly", + "reported", + "generated", "found", + "catalytic", + "acetate", + "developed", + "studies", + "utilised", "butyrate", - "materials", - "potential", - "triad", - "crystallisation", - "based", + "mutant", "mechanism", - "utilised", - "forming", - "mutagenesis", - "symmetrical", - "protein", - "dependent", + "materials", "kcat", - "histidine", - "additional", - "metalloenzymes", - "developed", - "dyad", - "previously" + "forming", + "values", + "crystallisation" ], "release_date":"2019-07-31", "publication":"\"Artificial beta-propeller protein-based hydrolases\", Chem.Commun.(Camb.), 55, 8880-8883", @@ -298013,31 +299095,31 @@ "seq_thr_sim_designed":[ { "sim":509.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":509.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":509.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":497.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":497.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":497.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":497.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":497.0, @@ -298045,11 +299127,11 @@ }, { "sim":497.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":497.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":497.0, @@ -298057,7 +299139,7 @@ }, { "sim":497.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":492.0, @@ -298081,11 +299163,11 @@ }, { "sim":484.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":484.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":484.0, @@ -298093,7 +299175,7 @@ }, { "sim":484.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":483.0, @@ -298133,15 +299215,15 @@ }, { "sim":168.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":168.0, - "partner":"5chb" + "partner":"5i1y" }, { "sim":168.0, - "partner":"5i1z" + "partner":"5chb" }, { "sim":165.0, @@ -298155,11 +299237,11 @@ "seq_thr_sim_natural":[ { "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":340.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":92.0, @@ -298239,11 +299321,11 @@ }, { "sim":51.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":51.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":50.0, @@ -298281,11 +299363,11 @@ ], "seq_max_sim_designed":{ "sim":509.0, - "partner":"6rel" + "partner":"6rek" }, "seq_max_sim_natural":{ "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9764999747, @@ -298343,57 +299425,57 @@ ], "subtitle":"Crystal structure of pizza6-sh with cu2+", "tags":[ - "metalloprotein", "computational design", + "metalloprotein", + "copper", "de novo protein", "artificial beta-propeller protein", - "pizza", - "copper" + "pizza" ], "keywords":[ "supramolecular", - "reported", - "acetate", - "pizza6", - "hydrolase", "chemistry", - "studies", - "hydrolysis", - "values", + "mutagenesis", + "triad", + "dependent", "investigated", - "complexes", - "highest", - "enzymes", - "catalytic", - "matched", - "artificial", + "histidine", + "additional", "bioinorganic", + "highest", + "metalloenzymes", + "complexes", "well", - "generated", - "mutant", + "hydrolysis", + "previously", + "based", + "potential", "residues", + "symmetrical", + "matched", + "protein", + "pizza6", + "artificial", + "hydrolase", + "enzymes", + "dyad", "highly", + "reported", + "generated", "found", + "catalytic", + "acetate", + "developed", + "studies", + "utilised", "butyrate", - "materials", - "potential", - "triad", - "crystallisation", - "based", + "mutant", "mechanism", - "utilised", - "forming", - "mutagenesis", - "symmetrical", - "protein", - "dependent", + "materials", "kcat", - "histidine", - "additional", - "metalloenzymes", - "developed", - "dyad", - "previously" + "forming", + "values", + "crystallisation" ], "release_date":"2019-07-31", "publication":"\"Artificial beta-propeller protein-based hydrolases\", Chem.Commun.(Camb.), 55, 8880-8883", @@ -298426,11 +299508,11 @@ "seq_thr_sim_designed":[ { "sim":509.0, - "partner":"6rel" + "partner":"6rem" }, { "sim":509.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":509.0, @@ -298438,19 +299520,19 @@ }, { "sim":497.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":497.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":497.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":497.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":497.0, @@ -298458,11 +299540,11 @@ }, { "sim":497.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":497.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":497.0, @@ -298470,7 +299552,7 @@ }, { "sim":497.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":492.0, @@ -298494,11 +299576,11 @@ }, { "sim":484.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":484.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":484.0, @@ -298506,7 +299588,7 @@ }, { "sim":484.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":483.0, @@ -298546,15 +299628,15 @@ }, { "sim":168.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":168.0, - "partner":"5chb" + "partner":"5i1y" }, { "sim":168.0, - "partner":"5i1z" + "partner":"5chb" }, { "sim":165.0, @@ -298568,11 +299650,11 @@ "seq_thr_sim_natural":[ { "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":340.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":92.0, @@ -298652,11 +299734,11 @@ }, { "sim":51.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":51.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":50.0, @@ -298690,11 +299772,11 @@ ], "seq_max_sim_designed":{ "sim":509.0, - "partner":"6rel" + "partner":"6rem" }, "seq_max_sim_natural":{ "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9588999748, @@ -298752,12 +299834,12 @@ ], "subtitle":"Crystal structure of pizza6-sh with cdcl2 nanocrystal", "tags":[ - "cadmium", - "metalloprotein", "computational design", - "nano", + "metalloprotein", "de novo protein", "artificial beta-propeller protein", + "cadmium", + "nano", "pizza" ], "keywords":[ @@ -298807,19 +299889,19 @@ }, { "sim":497.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":497.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":497.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":497.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":497.0, @@ -298827,11 +299909,11 @@ }, { "sim":497.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":497.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":497.0, @@ -298839,7 +299921,7 @@ }, { "sim":497.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":492.0, @@ -298863,11 +299945,11 @@ }, { "sim":484.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":484.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":484.0, @@ -298875,7 +299957,7 @@ }, { "sim":484.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":483.0, @@ -298915,15 +299997,15 @@ }, { "sim":168.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":168.0, - "partner":"5chb" + "partner":"5i1y" }, { "sim":168.0, - "partner":"5i1z" + "partner":"5chb" }, { "sim":165.0, @@ -298937,11 +300019,11 @@ "seq_thr_sim_natural":[ { "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":340.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":92.0, @@ -299029,11 +300111,11 @@ }, { "sim":51.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":51.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":50.0, @@ -299119,7 +300201,7 @@ }, "seq_max_sim_natural":{ "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9815999866, @@ -299179,8 +300261,8 @@ "tags":[ "computational design", "de novo protein", - "sulphate ion", "artificial beta-propeller protein", + "sulphate ion", "pizza" ], "keywords":[ @@ -299218,11 +300300,11 @@ "seq_thr_sim_designed":[ { "sim":509.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":509.0, - "partner":"6rek" + "partner":"6rel" }, { "sim":509.0, @@ -299230,19 +300312,19 @@ }, { "sim":497.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":497.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":497.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":497.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":497.0, @@ -299250,11 +300332,11 @@ }, { "sim":497.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":497.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":497.0, @@ -299262,7 +300344,7 @@ }, { "sim":497.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":492.0, @@ -299286,11 +300368,11 @@ }, { "sim":484.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":484.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":484.0, @@ -299298,7 +300380,7 @@ }, { "sim":484.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":483.0, @@ -299338,15 +300420,15 @@ }, { "sim":168.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":168.0, - "partner":"5chb" + "partner":"5i1y" }, { "sim":168.0, - "partner":"5i1z" + "partner":"5chb" }, { "sim":165.0, @@ -299360,11 +300442,11 @@ "seq_thr_sim_natural":[ { "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":340.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":92.0, @@ -299452,11 +300534,11 @@ }, { "sim":51.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":51.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":50.0, @@ -299526,11 +300608,11 @@ ], "seq_max_sim_designed":{ "sim":509.0, - "partner":"6rel" + "partner":"6rek" }, "seq_max_sim_natural":{ "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9717000127, @@ -299588,57 +300670,57 @@ ], "subtitle":"Crystal structure of 3fpizza6-sh with zn2+", "tags":[ - "metalloprotein", "computational design", - "zinc", + "metalloprotein", "de novo protein", "artificial beta-propeller protein", - "pizza" + "pizza", + "zinc" ], "keywords":[ "supramolecular", - "reported", - "acetate", - "pizza6", - "hydrolase", "chemistry", - "studies", - "hydrolysis", - "values", + "mutagenesis", + "triad", + "dependent", "investigated", - "complexes", - "highest", - "enzymes", - "catalytic", - "matched", - "artificial", + "histidine", + "additional", "bioinorganic", + "highest", + "metalloenzymes", + "complexes", "well", - "generated", - "mutant", + "hydrolysis", + "previously", + "based", + "potential", "residues", + "symmetrical", + "matched", + "protein", + "pizza6", + "artificial", + "hydrolase", + "enzymes", + "dyad", "highly", + "reported", + "generated", "found", + "catalytic", + "acetate", + "developed", + "studies", + "utilised", "butyrate", - "materials", - "potential", - "triad", - "crystallisation", - "based", + "mutant", "mechanism", - "utilised", - "forming", - "mutagenesis", - "symmetrical", - "protein", - "dependent", + "materials", "kcat", - "histidine", - "additional", - "metalloenzymes", - "developed", - "dyad", - "previously" + "forming", + "values", + "crystallisation" ], "release_date":"2019-07-31", "publication":"\"Artificial beta-propeller protein-based hydrolases\", Chem.Commun.(Camb.), 55, 8880-8883", @@ -299669,10 +300751,6 @@ "previous_design":"6rem", "next_design":"6reo", "seq_thr_sim_designed":[ - { - "sim":507.0, - "partner":"6reo" - }, { "sim":507.0, "partner":"6rli" @@ -299682,8 +300760,8 @@ "partner":"6rlh" }, { - "sim":485.0, - "partner":"6rel" + "sim":507.0, + "partner":"6reo" }, { "sim":485.0, @@ -299693,25 +300771,29 @@ "sim":485.0, "partner":"6rem" }, + { + "sim":485.0, + "partner":"6rel" + }, { "sim":485.0, "partner":"6rej" }, { "sim":474.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":474.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":474.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":474.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":474.0, @@ -299719,11 +300801,11 @@ }, { "sim":474.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":474.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":474.0, @@ -299731,7 +300813,7 @@ }, { "sim":474.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":469.0, @@ -299779,11 +300861,11 @@ }, { "sim":432.0, - "partner":"6i3a" + "partner":"6i38" }, { "sim":432.0, - "partner":"6i38" + "partner":"6i3a" }, { "sim":414.0, @@ -299791,15 +300873,15 @@ }, { "sim":160.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":160.0, - "partner":"5chb" + "partner":"5i1y" }, { "sim":160.0, - "partner":"5i1z" + "partner":"5chb" }, { "sim":157.0, @@ -299813,11 +300895,11 @@ "seq_thr_sim_natural":[ { "sim":329.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":329.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":92.0, @@ -299901,11 +300983,11 @@ }, { "sim":51.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":51.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":50.0, @@ -299951,11 +301033,11 @@ ], "seq_max_sim_designed":{ "sim":507.0, - "partner":"6reo" + "partner":"6rli" }, "seq_max_sim_natural":{ "sim":329.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.956799984, @@ -300013,8 +301095,8 @@ ], "subtitle":"Crystal structure of 3fpizza6-sh with sulphate ion", "tags":[ - "sulphate", "computational design", + "sulphate", "de novo protein", "artificial beta-propeller protein", "pizza" @@ -300058,23 +301140,23 @@ }, { "sim":507.0, - "partner":"6rlh" + "partner":"6ren" }, { "sim":507.0, - "partner":"6ren" + "partner":"6rlh" }, { "sim":485.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":485.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":485.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":485.0, @@ -300082,19 +301164,19 @@ }, { "sim":474.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":474.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":474.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":474.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":474.0, @@ -300102,11 +301184,11 @@ }, { "sim":474.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":474.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":474.0, @@ -300114,7 +301196,7 @@ }, { "sim":474.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":469.0, @@ -300162,11 +301244,11 @@ }, { "sim":432.0, - "partner":"6i3a" + "partner":"6i38" }, { "sim":432.0, - "partner":"6i38" + "partner":"6i3a" }, { "sim":414.0, @@ -300174,15 +301256,15 @@ }, { "sim":160.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":160.0, - "partner":"5chb" + "partner":"5i1y" }, { "sim":160.0, - "partner":"5i1z" + "partner":"5chb" }, { "sim":157.0, @@ -300196,11 +301278,11 @@ "seq_thr_sim_natural":[ { "sim":329.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":329.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":92.0, @@ -300300,11 +301382,11 @@ }, { "sim":51.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":51.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":50.0, @@ -300386,7 +301468,7 @@ }, "seq_max_sim_natural":{ "sim":329.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9797999859, @@ -300432,11 +301514,11 @@ ], "subtitle":"The structure of 3fpizza6-sh obtained via vapour diffusion", "tags":[ - "beta-propeller", - "artificial protein", - "de novo protein", "de novo", - "pizza" + "de novo protein", + "beta-propeller", + "pizza", + "artificial protein" ], "keywords":[ "description", @@ -300471,10 +301553,6 @@ "previous_design":"6reo", "next_design":"6rli", "seq_thr_sim_designed":[ - { - "sim":507.0, - "partner":"6reo" - }, { "sim":507.0, "partner":"6rli" @@ -300484,8 +301562,8 @@ "partner":"6ren" }, { - "sim":485.0, - "partner":"6rel" + "sim":507.0, + "partner":"6reo" }, { "sim":485.0, @@ -300495,25 +301573,29 @@ "sim":485.0, "partner":"6rem" }, + { + "sim":485.0, + "partner":"6rel" + }, { "sim":485.0, "partner":"6rej" }, { "sim":474.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":474.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":474.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":474.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":474.0, @@ -300521,11 +301603,11 @@ }, { "sim":474.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":474.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":474.0, @@ -300533,7 +301615,7 @@ }, { "sim":474.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":469.0, @@ -300581,11 +301663,11 @@ }, { "sim":432.0, - "partner":"6i3a" + "partner":"6i38" }, { "sim":432.0, - "partner":"6i38" + "partner":"6i3a" }, { "sim":414.0, @@ -300593,15 +301675,15 @@ }, { "sim":160.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":160.0, - "partner":"5chb" + "partner":"5i1y" }, { "sim":160.0, - "partner":"5i1z" + "partner":"5chb" }, { "sim":157.0, @@ -300615,11 +301697,11 @@ "seq_thr_sim_natural":[ { "sim":329.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":329.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":92.0, @@ -300719,11 +301801,11 @@ }, { "sim":51.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":51.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":50.0, @@ -300813,11 +301895,11 @@ ], "seq_max_sim_designed":{ "sim":507.0, - "partner":"6reo" + "partner":"6rli" }, "seq_max_sim_natural":{ "sim":329.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9873999953, @@ -300863,11 +301945,11 @@ ], "subtitle":"The structure of the self-assembled 3fpizza6-sh crystal", "tags":[ - "beta-propeller", - "artificial protein", - "de novo protein", "de novo", - "pizza" + "de novo protein", + "beta-propeller", + "pizza", + "artificial protein" ], "keywords":[ "description", @@ -300904,7 +301986,7 @@ "seq_thr_sim_designed":[ { "sim":507.0, - "partner":"6reo" + "partner":"6ren" }, { "sim":507.0, @@ -300912,19 +301994,19 @@ }, { "sim":507.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":485.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":485.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":485.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":485.0, @@ -300932,19 +302014,19 @@ }, { "sim":474.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":474.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":474.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":474.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":474.0, @@ -300952,11 +302034,11 @@ }, { "sim":474.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":474.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":474.0, @@ -300964,7 +302046,7 @@ }, { "sim":474.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":469.0, @@ -301012,11 +302094,11 @@ }, { "sim":432.0, - "partner":"6i3a" + "partner":"6i38" }, { "sim":432.0, - "partner":"6i38" + "partner":"6i3a" }, { "sim":414.0, @@ -301024,15 +302106,15 @@ }, { "sim":160.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":160.0, - "partner":"5chb" + "partner":"5i1y" }, { "sim":160.0, - "partner":"5i1z" + "partner":"5chb" }, { "sim":157.0, @@ -301046,11 +302128,11 @@ "seq_thr_sim_natural":[ { "sim":329.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":329.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":92.0, @@ -301150,11 +302232,11 @@ }, { "sim":51.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":51.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":50.0, @@ -301252,11 +302334,11 @@ ], "seq_max_sim_designed":{ "sim":507.0, - "partner":"6reo" + "partner":"6ren" }, "seq_max_sim_natural":{ "sim":329.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9912999868, @@ -301375,80 +302457,80 @@ "subtitle":"Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 1 (nmt-c0003)", "tags":[ "trypanosoma brucei", - "pteridine reductase", "ptr1", "pteridine based inhibitors", "tbptr1", - "oxidoreductase" + "oxidoreductase", + "pteridine reductase" ], "keywords":[ + "ptr1", + "agents", + "design", + "development", + "iterations", + "dhfr", + "moreover", + "cycle", + "exhibited", + "determination", + "multiple", + "allowed", + "combining", + "three", + "apparent", "derivatives", + "structure", + "multidimensional", + "selective", "reductase", - "combining", + "50", + "targets", + "multitarget", "results", - "values", - "multiple", - "exhibited", + "provide", + "dihydrofolate", + "target", + "optimization", + "basis", "applicable", "approach", + "drug", "showing", - "micromolar", - "antiparasitic", "polypharmacology", - "along", - "drug", - "human", + "generally", + "antiparasitic", "expect", - "determination", - "optimization", - "discovery", - "1", - "moreover", + "pteridine", + "systematic", + "multidisciplinary", "yielded", - "ec", - "ptr1", + "compounds", + "retaining", "difficult", - "multidisciplinary", + "relationship", + "picomolar", + "major", + "discovery", "found", - "multidimensional", - "provide", - "problem", - "50", - "pteridine", - "systematic", - "target", + "along", + "present", "inhibition", - "picomolar", + "problem", + "versus", + "ec", + "derivation", "brucei", - "generally", - "design", - "selective", - "crystallographic", - "multitarget", - "apparent", "nanomolar", + "crystallographic", + "human", "parasite", - "dihydrofolate", - "submicromolar", - "basis", - "agents", - "present", - "targets", - "dhfr", - "development", - "versus", - "structure", - "three", - "allowed", - "relationship", - "compounds", "computational", - "retaining", - "major", + "micromolar", + "1", + "values", "novel", - "iterations", - "derivation", - "cycle" + "submicromolar" ], "release_date":"2020-07-15", "publication":"\"Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1\", J.Med.Chem., 65, 9011-9033", @@ -301674,77 +302756,77 @@ ], "subtitle":"Structure of d25 fab in complex with scaffold s0_2.126", "tags":[ - "hrsv", + "fab fragment", "antiviral protein", "d25", - "fab fragment" + "hrsv" ], "keywords":[ - "responses", - "cornerstone", - "neutralization", - "structural", - "toward", - "opens", - "cocktails", - "called", - "overall", "vaccinology", - "functional", - "proteins", - "syncytial", - "virus", - "immunogens", - "lack", - "neutralizing", - "respiratory", + "complex", "defined", - "approach", - "de", - "novo", - "applicable", - "presenting", - "challenge", - "antibody", - "possibility", - "induction", - "preexisting", + "responses", "engineered", - "remains", - "mice", - "successful", "displaying", - "nonhuman", - "methodological", - "topobuilder", - "primates", - "induced", - "repertoire", - "robust", - "specific", - "furthermore", - "generally", "design", - "protein", - "precise", - "present", - "complex", - "natural", + "methodological", + "however", + "immunogens", + "structural", "development", - "function", - "three", + "opens", + "de", + "natural", + "functional", + "vaccines", + "furthermore", + "overall", "biological", - "motifs", + "remains", + "three", + "respiratory", "epitopes", - "vaccines", - "however", - "major", + "targeting", + "called", + "specific", + "virus", + "successful", + "therapeutic", + "presenting", + "protein", "antibodies", + "function", + "applicable", + "approach", + "syncytial", + "proteins", + "generally", + "algorithm", + "novo", "refocused", - "therapeutic", + "neutralization", + "repertoire", + "neutralizing", + "mice", + "preexisting", + "motifs", + "major", + "induction", "expanding", - "algorithm", - "targeting" + "present", + "precise", + "cornerstone", + "induced", + "toward", + "nonhuman", + "cocktails", + "primates", + "challenge", + "possibility", + "topobuilder", + "robust", + "lack", + "antibody" ], "release_date":"2020-04-22", "publication":"\"De novo protein design enables the precise induction of RSV-neutralizing antibodies\", Science, 368", @@ -301864,131 +302946,131 @@ ], "subtitle":"Designed armadillo repeat protein lock1 bound to (kr)4klsf target", "tags":[ - "peptide binder", "de novo protein", "repeat protein", + "peptide binder", "designed armadillo repeat protein" ], "keywords":[ - "confirm", - "many", - "possibilities", + "role", + "repeat", + "unstructured", "intermolecular", - "specificity", - "analytes", - "selection", - "modules", + "side", + "lead", "acid", - "time", - "peptide", - "determination", - "designed", + "assays", + "short", + "new", + "protein", + "prefer", + "pockets", + "linear", + "proteomes", + "binding", + "confirmed", "register", - "hindering", - "repetitive", - "smaller", - "order", - "sequences", - "f\u00f6rster", - "interactions", - "bind", - "circumventing", + "resonance", "split", - "structure", - "repeat", - "however", + "principle", + "confirm", + "chains", + "away", + "flipping", "solve", - "even", - "lysine", - "middle", - "proteins", "play", - "frequent", - "scalable", - "arginine", - "linear", - "parts", - "assays", - "short", - "elongated", - "yet", - "grafting", - "darmrps", + "select", + "however", + "specificity", + "lysine", + "due", + "determination", "furthermore", - "modularity", - "flipping", - "lead", - "away", - "mutual", - "quest", - "pockets", - "solution", - "assembly", - "resonance", "armadillo", - "role", - "prefer", - "consensus", + "epitopes", "discovered", + "quest", + "middle", + "library", + "elongated", + "optimization", + "analytes", + "bind", + "orthogonal", + "scalable", + "bound", + "proteins", + "modules", + "moved", "rounds", + "consensus", + "modular", + "mutual", + "possibilities", "created", + "computational", + "combination", + "peptide", + "pocket", + "design", + "energy", + "selection", + "selections", + "even", + "yet", + "absence", + "different", + "shifts", + "assembly", "properties", - "classical", - "predefined", - "amino", "carries", - "orthogonal", - "whole", - "thereby", - "proteomes", - "selections", - "optimization", - "specificities", - "would", + "also", + "parts", + "grafting", "sliding", - "transfer", - "design", + "amino", + "solution", + "modularity", + "time", "sequence", - "epitopes", - "energy", - "could", + "system", "retaining", - "preselected", - "important", - "library", - "chains", + "peptides", + "whole", + "desired", + "could", + "designed", + "order", + "sequences", + "many", "one", - "also", - "rational", - "principle", "way", - "desired", - "peptides", - "select", - "reassembled", - "modular", + "classical", + "specificities", + "rational", "moving", - "different", - "confirmed", - "absence", - "problem", - "due", - "system", - "underlining", - "bound", - "protein", - "shifts", - "arbitrary", - "unstructured", - "combination", - "computational", + "important", + "predefined", + "repetitive", + "structure", + "thereby", + "circumventing", + "interactions", + "frequent", + "darmrps", + "hindering", + "f\u00f6rster", + "would", + "reassembled", + "arginine", + "smaller", "diagnostic", - "side", - "pocket", - "binding", - "moved", "libraries", - "new" + "problem", + "arbitrary", + "preselected", + "underlining", + "transfer" ], "release_date":"2020-02-19", "publication":"\"Structure-Guided Design of a Peptide Lock for Modular Peptide Binders\", Acs Chem.Biol., 15, 457-468", @@ -302021,11 +303103,11 @@ "seq_thr_sim_designed":[ { "sim":519.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":519.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":519.0, @@ -302037,19 +303119,19 @@ }, { "sim":519.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":519.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":514.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":514.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":501.0, @@ -302121,11 +303203,11 @@ }, { "sim":290.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":290.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":288.0, @@ -302223,15 +303305,15 @@ }, { "sim":184.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":184.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":184.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":184.0, @@ -302239,15 +303321,15 @@ }, { "sim":183.0, - "partner":"4pvz" + "partner":"1bk5" }, { "sim":183.0, - "partner":"1bk5" + "partner":"1bk6" }, { "sim":183.0, - "partner":"1bk6" + "partner":"4pvz" }, { "sim":183.0, @@ -302279,23 +303361,23 @@ }, { "sim":179.0, - "partner":"6bwa" + "partner":"6bvv" }, { "sim":179.0, - "partner":"6bvz" + "partner":"6bw9" }, { "sim":179.0, - "partner":"6bwb" + "partner":"6bwa" }, { "sim":179.0, - "partner":"6bvv" + "partner":"6bvz" }, { "sim":179.0, - "partner":"6bw9" + "partner":"6bwb" }, { "sim":179.0, @@ -302331,11 +303413,11 @@ }, { "sim":177.0, - "partner":"4u5o" + "partner":"3ve6" }, { "sim":177.0, - "partner":"3ve6" + "partner":"6mjl" }, { "sim":177.0, @@ -302345,10 +303427,6 @@ "sim":177.0, "partner":"4u5s" }, - { - "sim":177.0, - "partner":"6mjl" - }, { "sim":177.0, "partner":"4u5u" @@ -302367,7 +303445,7 @@ }, { "sim":177.0, - "partner":"3l3q" + "partner":"4u5o" }, { "sim":177.0, @@ -302375,11 +303453,11 @@ }, { "sim":177.0, - "partner":"5hhg" + "partner":"3l3q" }, { "sim":177.0, - "partner":"3btr" + "partner":"5hhg" }, { "sim":177.0, @@ -302387,7 +303465,7 @@ }, { "sim":177.0, - "partner":"1y2a" + "partner":"3btr" }, { "sim":177.0, @@ -302397,6 +303475,10 @@ "sim":177.0, "partner":"4zdu" }, + { + "sim":177.0, + "partner":"1y2a" + }, { "sim":177.0, "partner":"5h43" @@ -302425,25 +303507,17 @@ "sim":177.0, "partner":"5k9s" }, - { - "sim":177.0, - "partner":"3q5u" - }, - { - "sim":177.0, - "partner":"5wum" - }, { "sim":177.0, "partner":"5wun" }, { "sim":177.0, - "partner":"4oih" + "partner":"6p6a" }, { "sim":177.0, - "partner":"6p6a" + "partner":"4oih" }, { "sim":177.0, @@ -302455,15 +303529,15 @@ }, { "sim":177.0, - "partner":"1ejl" + "partner":"4yi0" }, { "sim":177.0, - "partner":"4yi0" + "partner":"3knd" }, { "sim":177.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":177.0, @@ -302475,11 +303549,11 @@ }, { "sim":177.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":177.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":177.0, @@ -302487,7 +303561,11 @@ }, { "sim":177.0, - "partner":"3zir" + "partner":"3q5u" + }, + { + "sim":177.0, + "partner":"5wum" }, { "sim":177.0, @@ -302509,6 +303587,10 @@ "sim":177.0, "partner":"3ziq" }, + { + "sim":177.0, + "partner":"3zir" + }, { "sim":177.0, "partner":"4uaf" @@ -302545,10 +303627,6 @@ "sim":177.0, "partner":"4ba3" }, - { - "sim":177.0, - "partner":"4htv" - }, { "sim":177.0, "partner":"5umz" @@ -302563,19 +303641,7 @@ }, { "sim":177.0, - "partner":"3rzx" - }, - { - "sim":177.0, - "partner":"5e6q" - }, - { - "sim":177.0, - "partner":"3oqs" - }, - { - "sim":177.0, - "partner":"5w4f" + "partner":"4htv" }, { "sim":177.0, @@ -302583,16 +303649,12 @@ }, { "sim":177.0, - "partner":"6bw0" + "partner":"6bw1" }, { "sim":177.0, "partner":"5w4g" }, - { - "sim":177.0, - "partner":"6bw1" - }, { "sim":177.0, "partner":"3ukw" @@ -302643,15 +303705,15 @@ }, { "sim":177.0, - "partner":"3uvu" + "partner":"6bvt" }, { "sim":177.0, - "partner":"5u5r" + "partner":"3uvu" }, { "sim":177.0, - "partner":"6bvt" + "partner":"5u5r" }, { "sim":177.0, @@ -302665,6 +303727,26 @@ "sim":177.0, "partner":"5w4e" }, + { + "sim":177.0, + "partner":"3rzx" + }, + { + "sim":177.0, + "partner":"5e6q" + }, + { + "sim":177.0, + "partner":"3oqs" + }, + { + "sim":177.0, + "partner":"5w4f" + }, + { + "sim":177.0, + "partner":"6bw0" + }, { "sim":177.0, "partner":"5huw" @@ -302747,35 +303829,35 @@ }, { "sim":104.0, - "partner":"1m1e" + "partner":"1v18" }, { "sim":104.0, - "partner":"4evt" + "partner":"4ev8" }, { "sim":104.0, - "partner":"1v18" + "partner":"4ev9" }, { "sim":104.0, - "partner":"4ev8" + "partner":"4evp" }, { "sim":104.0, - "partner":"1i7w" + "partner":"4eva" }, { "sim":104.0, - "partner":"4ev9" + "partner":"1i7w" }, { "sim":104.0, - "partner":"4evp" + "partner":"1m1e" }, { "sim":104.0, - "partner":"4eva" + "partner":"4evt" }, { "sim":104.0, @@ -302848,7 +303930,7 @@ ], "seq_max_sim_designed":{ "sim":519.0, - "partner":"5mfh" + "partner":"5aei" }, "seq_max_sim_natural":{ "sim":519.0, @@ -302914,131 +303996,131 @@ ], "subtitle":"Designed armadillo repeat protein lock2 fused to target peptide krkrkakitw", "tags":[ - "peptide binder", "de novo protein", "repeat protein", + "peptide binder", "designed armadillo repeat protein" ], "keywords":[ - "confirm", - "many", - "possibilities", + "role", + "repeat", + "unstructured", "intermolecular", - "specificity", - "analytes", - "selection", - "modules", + "side", + "lead", "acid", - "time", - "peptide", - "determination", - "designed", + "assays", + "short", + "new", + "protein", + "prefer", + "pockets", + "linear", + "proteomes", + "binding", + "confirmed", "register", - "hindering", - "repetitive", - "smaller", - "order", - "sequences", - "f\u00f6rster", - "interactions", - "bind", - "circumventing", + "resonance", "split", - "structure", - "repeat", - "however", + "principle", + "confirm", + "chains", + "away", + "flipping", "solve", - "even", - "lysine", - "middle", - "proteins", "play", - "frequent", - "scalable", - "arginine", - "linear", - "parts", - "assays", - "short", - "elongated", - "yet", - "grafting", - "darmrps", + "select", + "however", + "specificity", + "lysine", + "due", + "determination", "furthermore", - "modularity", - "flipping", - "lead", - "away", - "mutual", - "quest", - "pockets", - "solution", - "assembly", - "resonance", "armadillo", - "role", - "prefer", - "consensus", + "epitopes", "discovered", + "quest", + "middle", + "library", + "elongated", + "optimization", + "analytes", + "bind", + "orthogonal", + "scalable", + "bound", + "proteins", + "modules", + "moved", "rounds", + "consensus", + "modular", + "mutual", + "possibilities", "created", + "computational", + "combination", + "peptide", + "pocket", + "design", + "energy", + "selection", + "selections", + "even", + "yet", + "absence", + "different", + "shifts", + "assembly", "properties", - "classical", - "predefined", - "amino", "carries", - "orthogonal", - "whole", - "thereby", - "proteomes", - "selections", - "optimization", - "specificities", - "would", + "also", + "parts", + "grafting", "sliding", - "transfer", - "design", + "amino", + "solution", + "modularity", + "time", "sequence", - "epitopes", - "energy", - "could", + "system", "retaining", - "preselected", - "important", - "library", - "chains", + "peptides", + "whole", + "desired", + "could", + "designed", + "order", + "sequences", + "many", "one", - "also", - "rational", - "principle", "way", - "desired", - "peptides", - "select", - "reassembled", - "modular", + "classical", + "specificities", + "rational", "moving", - "different", - "confirmed", - "absence", - "problem", - "due", - "system", - "underlining", - "bound", - "protein", - "shifts", - "arbitrary", - "unstructured", - "combination", - "computational", + "important", + "predefined", + "repetitive", + "structure", + "thereby", + "circumventing", + "interactions", + "frequent", + "darmrps", + "hindering", + "f\u00f6rster", + "would", + "reassembled", + "arginine", + "smaller", "diagnostic", - "side", - "pocket", - "binding", - "moved", "libraries", - "new" + "problem", + "arbitrary", + "preselected", + "underlining", + "transfer" ], "release_date":"2020-02-19", "publication":"\"Structure-Guided Design of a Peptide Lock for Modular Peptide Binders\", Acs Chem.Biol., 15, 457-468", @@ -303075,11 +304157,11 @@ }, { "sim":514.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":514.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":514.0, @@ -303095,11 +304177,11 @@ }, { "sim":514.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":514.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":514.0, @@ -303171,11 +304253,11 @@ }, { "sim":290.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":290.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":287.0, @@ -303265,11 +304347,11 @@ }, { "sim":174.0, - "partner":"4pvz" + "partner":"1bk5" }, { "sim":174.0, - "partner":"1bk5" + "partner":"4pvz" }, { "sim":174.0, @@ -303297,15 +304379,15 @@ }, { "sim":173.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":173.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":173.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":173.0, @@ -303345,23 +304427,23 @@ }, { "sim":168.0, - "partner":"6bwa" + "partner":"6bvv" }, { "sim":168.0, - "partner":"6bvz" + "partner":"6bw9" }, { "sim":168.0, - "partner":"6bwb" + "partner":"6bwa" }, { "sim":168.0, - "partner":"6bvv" + "partner":"6bvz" }, { "sim":168.0, - "partner":"6bw9" + "partner":"6bwb" }, { "sim":168.0, @@ -303381,11 +304463,11 @@ }, { "sim":167.0, - "partner":"4u5o" + "partner":"3ve6" }, { "sim":167.0, - "partner":"3ve6" + "partner":"6mjl" }, { "sim":167.0, @@ -303395,10 +304477,6 @@ "sim":167.0, "partner":"4u5s" }, - { - "sim":167.0, - "partner":"6mjl" - }, { "sim":167.0, "partner":"4u5u" @@ -303417,7 +304495,7 @@ }, { "sim":167.0, - "partner":"3l3q" + "partner":"4u5o" }, { "sim":167.0, @@ -303425,11 +304503,11 @@ }, { "sim":167.0, - "partner":"5hhg" + "partner":"3l3q" }, { "sim":167.0, - "partner":"3btr" + "partner":"5hhg" }, { "sim":167.0, @@ -303437,7 +304515,7 @@ }, { "sim":167.0, - "partner":"1y2a" + "partner":"3btr" }, { "sim":167.0, @@ -303447,6 +304525,10 @@ "sim":167.0, "partner":"4zdu" }, + { + "sim":167.0, + "partner":"1y2a" + }, { "sim":167.0, "partner":"6iw8" @@ -303467,10 +304549,6 @@ "sim":167.0, "partner":"1ial" }, - { - "sim":167.0, - "partner":"3zir" - }, { "sim":167.0, "partner":"2ynr" @@ -303491,33 +304569,37 @@ "sim":167.0, "partner":"3ziq" }, + { + "sim":167.0, + "partner":"3zir" + }, { "sim":166.0, "partner":"5k9s" }, { "sim":166.0, - "partner":"3q5u" + "partner":"5wun" }, { "sim":166.0, - "partner":"5wum" + "partner":"6p6a" }, { "sim":166.0, - "partner":"5wun" + "partner":"4oih" }, { "sim":166.0, - "partner":"4oih" + "partner":"5x8n" }, { "sim":166.0, - "partner":"6p6a" + "partner":"4yi0" }, { "sim":166.0, - "partner":"5x8n" + "partner":"3knd" }, { "sim":166.0, @@ -303525,31 +304607,31 @@ }, { "sim":166.0, - "partner":"4yi0" + "partner":"1ejy" }, { "sim":166.0, - "partner":"3knd" + "partner":"5b56" }, { "sim":166.0, - "partner":"1ejy" + "partner":"1pjm" }, { "sim":166.0, - "partner":"5b56" + "partner":"1iq1" }, { "sim":166.0, - "partner":"1iq1" + "partner":"1pjn" }, { "sim":166.0, - "partner":"1pjm" + "partner":"3q5u" }, { "sim":166.0, - "partner":"1pjn" + "partner":"5wum" }, { "sim":166.0, @@ -303571,10 +304653,6 @@ "sim":166.0, "partner":"4ba3" }, - { - "sim":166.0, - "partner":"4htv" - }, { "sim":166.0, "partner":"5umz" @@ -303589,23 +304667,7 @@ }, { "sim":166.0, - "partner":"3rzx" - }, - { - "sim":166.0, - "partner":"5e6q" - }, - { - "sim":166.0, - "partner":"3oqs" - }, - { - "sim":166.0, - "partner":"5w4f" - }, - { - "sim":166.0, - "partner":"6d7m" + "partner":"4htv" }, { "sim":166.0, @@ -303613,16 +304675,12 @@ }, { "sim":166.0, - "partner":"6bw0" + "partner":"6bw1" }, { "sim":166.0, "partner":"5w4g" }, - { - "sim":166.0, - "partner":"6bw1" - }, { "sim":166.0, "partner":"3ukw" @@ -303673,15 +304731,15 @@ }, { "sim":166.0, - "partner":"3uvu" + "partner":"6bvt" }, { "sim":166.0, - "partner":"5u5r" + "partner":"3uvu" }, { "sim":166.0, - "partner":"6bvt" + "partner":"5u5r" }, { "sim":166.0, @@ -303695,6 +304753,30 @@ "sim":166.0, "partner":"5w4e" }, + { + "sim":166.0, + "partner":"3rzx" + }, + { + "sim":166.0, + "partner":"5e6q" + }, + { + "sim":166.0, + "partner":"6d7m" + }, + { + "sim":166.0, + "partner":"3oqs" + }, + { + "sim":166.0, + "partner":"5w4f" + }, + { + "sim":166.0, + "partner":"6bw0" + }, { "sim":166.0, "partner":"5huw" @@ -303833,131 +304915,131 @@ ], "subtitle":"Designed armadillo repeat protein lock2 fused to target peptide krkrkaklsf", "tags":[ - "peptide binder", "de novo protein", "repeat protein", + "peptide binder", "designed armadillo repeat protein" ], "keywords":[ - "confirm", - "many", - "possibilities", + "role", + "repeat", + "unstructured", "intermolecular", - "specificity", - "analytes", - "selection", - "modules", + "side", + "lead", "acid", - "time", - "peptide", - "determination", - "designed", + "assays", + "short", + "new", + "protein", + "prefer", + "pockets", + "linear", + "proteomes", + "binding", + "confirmed", "register", - "hindering", - "repetitive", - "smaller", - "order", - "sequences", - "f\u00f6rster", - "interactions", - "bind", - "circumventing", + "resonance", "split", - "structure", - "repeat", - "however", + "principle", + "confirm", + "chains", + "away", + "flipping", "solve", - "even", - "lysine", - "middle", - "proteins", "play", - "frequent", - "scalable", - "arginine", - "linear", - "parts", - "assays", - "short", - "elongated", - "yet", - "grafting", - "darmrps", + "select", + "however", + "specificity", + "lysine", + "due", + "determination", "furthermore", - "modularity", - "flipping", - "lead", - "away", - "mutual", - "quest", - "pockets", - "solution", - "assembly", - "resonance", "armadillo", - "role", - "prefer", - "consensus", + "epitopes", "discovered", + "quest", + "middle", + "library", + "elongated", + "optimization", + "analytes", + "bind", + "orthogonal", + "scalable", + "bound", + "proteins", + "modules", + "moved", "rounds", + "consensus", + "modular", + "mutual", + "possibilities", "created", + "computational", + "combination", + "peptide", + "pocket", + "design", + "energy", + "selection", + "selections", + "even", + "yet", + "absence", + "different", + "shifts", + "assembly", "properties", - "classical", - "predefined", - "amino", "carries", - "orthogonal", - "whole", - "thereby", - "proteomes", - "selections", - "optimization", - "specificities", - "would", + "also", + "parts", + "grafting", "sliding", - "transfer", - "design", + "amino", + "solution", + "modularity", + "time", "sequence", - "epitopes", - "energy", - "could", + "system", "retaining", - "preselected", - "important", - "library", - "chains", + "peptides", + "whole", + "desired", + "could", + "designed", + "order", + "sequences", + "many", "one", - "also", - "rational", - "principle", "way", - "desired", - "peptides", - "select", - "reassembled", - "modular", + "classical", + "specificities", + "rational", "moving", - "different", - "confirmed", - "absence", - "problem", - "due", - "system", - "underlining", - "bound", - "protein", - "shifts", - "arbitrary", - "unstructured", - "combination", - "computational", + "important", + "predefined", + "repetitive", + "structure", + "thereby", + "circumventing", + "interactions", + "frequent", + "darmrps", + "hindering", + "f\u00f6rster", + "would", + "reassembled", + "arginine", + "smaller", "diagnostic", - "side", - "pocket", - "binding", - "moved", "libraries", - "new" + "problem", + "arbitrary", + "preselected", + "underlining", + "transfer" ], "release_date":"2020-02-19", "publication":"\"Structure-Guided Design of a Peptide Lock for Modular Peptide Binders\", Acs Chem.Biol., 15, 457-468", @@ -303994,11 +305076,11 @@ }, { "sim":514.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":514.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":514.0, @@ -304014,11 +305096,11 @@ }, { "sim":514.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":514.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":514.0, @@ -304090,11 +305172,11 @@ }, { "sim":290.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":290.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":287.0, @@ -304184,11 +305266,11 @@ }, { "sim":174.0, - "partner":"4pvz" + "partner":"1bk5" }, { "sim":174.0, - "partner":"1bk5" + "partner":"4pvz" }, { "sim":174.0, @@ -304216,15 +305298,15 @@ }, { "sim":173.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":173.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":173.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":173.0, @@ -304264,23 +305346,23 @@ }, { "sim":168.0, - "partner":"6bwa" + "partner":"6bvv" }, { "sim":168.0, - "partner":"6bvz" + "partner":"6bw9" }, { "sim":168.0, - "partner":"6bwb" + "partner":"6bwa" }, { "sim":168.0, - "partner":"6bvv" + "partner":"6bvz" }, { "sim":168.0, - "partner":"6bw9" + "partner":"6bwb" }, { "sim":168.0, @@ -304300,11 +305382,11 @@ }, { "sim":167.0, - "partner":"4u5o" + "partner":"3ve6" }, { "sim":167.0, - "partner":"3ve6" + "partner":"6mjl" }, { "sim":167.0, @@ -304314,10 +305396,6 @@ "sim":167.0, "partner":"4u5s" }, - { - "sim":167.0, - "partner":"6mjl" - }, { "sim":167.0, "partner":"4u5u" @@ -304336,7 +305414,7 @@ }, { "sim":167.0, - "partner":"3l3q" + "partner":"4u5o" }, { "sim":167.0, @@ -304344,11 +305422,11 @@ }, { "sim":167.0, - "partner":"5hhg" + "partner":"3l3q" }, { "sim":167.0, - "partner":"3btr" + "partner":"5hhg" }, { "sim":167.0, @@ -304356,7 +305434,7 @@ }, { "sim":167.0, - "partner":"1y2a" + "partner":"3btr" }, { "sim":167.0, @@ -304366,6 +305444,10 @@ "sim":167.0, "partner":"4zdu" }, + { + "sim":167.0, + "partner":"1y2a" + }, { "sim":167.0, "partner":"6iw8" @@ -304386,10 +305468,6 @@ "sim":167.0, "partner":"1ial" }, - { - "sim":167.0, - "partner":"3zir" - }, { "sim":167.0, "partner":"2ynr" @@ -304410,33 +305488,37 @@ "sim":167.0, "partner":"3ziq" }, + { + "sim":167.0, + "partner":"3zir" + }, { "sim":166.0, "partner":"5k9s" }, { "sim":166.0, - "partner":"3q5u" + "partner":"5wun" }, { "sim":166.0, - "partner":"5wum" + "partner":"6p6a" }, { "sim":166.0, - "partner":"5wun" + "partner":"4oih" }, { "sim":166.0, - "partner":"4oih" + "partner":"5x8n" }, { "sim":166.0, - "partner":"6p6a" + "partner":"4yi0" }, { "sim":166.0, - "partner":"5x8n" + "partner":"3knd" }, { "sim":166.0, @@ -304444,31 +305526,31 @@ }, { "sim":166.0, - "partner":"4yi0" + "partner":"1ejy" }, { "sim":166.0, - "partner":"3knd" + "partner":"5b56" }, { "sim":166.0, - "partner":"1ejy" + "partner":"1pjm" }, { "sim":166.0, - "partner":"5b56" + "partner":"1iq1" }, { "sim":166.0, - "partner":"1iq1" + "partner":"1pjn" }, { "sim":166.0, - "partner":"1pjm" + "partner":"3q5u" }, { "sim":166.0, - "partner":"1pjn" + "partner":"5wum" }, { "sim":166.0, @@ -304490,10 +305572,6 @@ "sim":166.0, "partner":"4ba3" }, - { - "sim":166.0, - "partner":"4htv" - }, { "sim":166.0, "partner":"5umz" @@ -304508,23 +305586,7 @@ }, { "sim":166.0, - "partner":"3rzx" - }, - { - "sim":166.0, - "partner":"5e6q" - }, - { - "sim":166.0, - "partner":"3oqs" - }, - { - "sim":166.0, - "partner":"5w4f" - }, - { - "sim":166.0, - "partner":"6d7m" + "partner":"4htv" }, { "sim":166.0, @@ -304532,16 +305594,12 @@ }, { "sim":166.0, - "partner":"6bw0" + "partner":"6bw1" }, { "sim":166.0, "partner":"5w4g" }, - { - "sim":166.0, - "partner":"6bw1" - }, { "sim":166.0, "partner":"3ukw" @@ -304592,15 +305650,15 @@ }, { "sim":166.0, - "partner":"3uvu" + "partner":"6bvt" }, { "sim":166.0, - "partner":"5u5r" + "partner":"3uvu" }, { "sim":166.0, - "partner":"6bvt" + "partner":"5u5r" }, { "sim":166.0, @@ -304614,6 +305672,30 @@ "sim":166.0, "partner":"5w4e" }, + { + "sim":166.0, + "partner":"3rzx" + }, + { + "sim":166.0, + "partner":"5e6q" + }, + { + "sim":166.0, + "partner":"6d7m" + }, + { + "sim":166.0, + "partner":"3oqs" + }, + { + "sim":166.0, + "partner":"5w4f" + }, + { + "sim":166.0, + "partner":"6bw0" + }, { "sim":166.0, "partner":"5huw" @@ -304752,131 +305834,131 @@ ], "subtitle":"Designed armadillo repeat protein internal lock1 fused to target peptide krkrklkfkr", "tags":[ - "peptide binder", "de novo protein", "repeat protein", + "peptide binder", "designed armadillo repeat protein" ], "keywords":[ - "confirm", - "many", - "possibilities", + "role", + "repeat", + "unstructured", "intermolecular", - "specificity", - "analytes", - "selection", - "modules", + "side", + "lead", "acid", - "time", - "peptide", - "determination", - "designed", + "assays", + "short", + "new", + "protein", + "prefer", + "pockets", + "linear", + "proteomes", + "binding", + "confirmed", "register", - "hindering", - "repetitive", - "smaller", - "order", - "sequences", - "f\u00f6rster", - "interactions", - "bind", - "circumventing", + "resonance", "split", - "structure", - "repeat", - "however", + "principle", + "confirm", + "chains", + "away", + "flipping", "solve", - "even", - "lysine", - "middle", - "proteins", "play", - "frequent", - "scalable", - "arginine", - "linear", - "parts", - "assays", - "short", - "elongated", - "yet", - "grafting", - "darmrps", + "select", + "however", + "specificity", + "lysine", + "due", + "determination", "furthermore", - "modularity", - "flipping", - "lead", - "away", - "mutual", - "quest", - "pockets", - "solution", - "assembly", - "resonance", "armadillo", - "role", - "prefer", - "consensus", + "epitopes", "discovered", + "quest", + "middle", + "library", + "elongated", + "optimization", + "analytes", + "bind", + "orthogonal", + "scalable", + "bound", + "proteins", + "modules", + "moved", "rounds", + "consensus", + "modular", + "mutual", + "possibilities", "created", + "computational", + "combination", + "peptide", + "pocket", + "design", + "energy", + "selection", + "selections", + "even", + "yet", + "absence", + "different", + "shifts", + "assembly", "properties", - "classical", - "predefined", - "amino", "carries", - "orthogonal", - "whole", - "thereby", - "proteomes", - "selections", - "optimization", - "specificities", - "would", + "also", + "parts", + "grafting", "sliding", - "transfer", - "design", + "amino", + "solution", + "modularity", + "time", "sequence", - "epitopes", - "energy", - "could", + "system", "retaining", - "preselected", - "important", - "library", - "chains", + "peptides", + "whole", + "desired", + "could", + "designed", + "order", + "sequences", + "many", "one", - "also", - "rational", - "principle", "way", - "desired", - "peptides", - "select", - "reassembled", - "modular", + "classical", + "specificities", + "rational", "moving", - "different", - "confirmed", - "absence", - "problem", - "due", - "system", - "underlining", - "bound", - "protein", - "shifts", - "arbitrary", - "unstructured", - "combination", - "computational", + "important", + "predefined", + "repetitive", + "structure", + "thereby", + "circumventing", + "interactions", + "frequent", + "darmrps", + "hindering", + "f\u00f6rster", + "would", + "reassembled", + "arginine", + "smaller", "diagnostic", - "side", - "pocket", - "binding", - "moved", "libraries", - "new" + "problem", + "arbitrary", + "preselected", + "underlining", + "transfer" ], "release_date":"2020-02-19", "publication":"\"Structure-Guided Design of a Peptide Lock for Modular Peptide Binders\", Acs Chem.Biol., 15, 457-468", @@ -304929,11 +306011,11 @@ }, { "sim":514.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":514.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":514.0, @@ -304945,11 +306027,11 @@ }, { "sim":514.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":514.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":510.0, @@ -305009,11 +306091,11 @@ }, { "sim":296.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":296.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":286.0, @@ -305143,11 +306225,11 @@ }, { "sim":209.0, - "partner":"4u5o" + "partner":"3ve6" }, { "sim":209.0, - "partner":"3ve6" + "partner":"6mjl" }, { "sim":209.0, @@ -305157,10 +306239,6 @@ "sim":209.0, "partner":"4u5s" }, - { - "sim":209.0, - "partner":"6mjl" - }, { "sim":209.0, "partner":"4u5u" @@ -305179,7 +306257,7 @@ }, { "sim":209.0, - "partner":"3l3q" + "partner":"4u5o" }, { "sim":209.0, @@ -305187,11 +306265,11 @@ }, { "sim":209.0, - "partner":"5hhg" + "partner":"3l3q" }, { "sim":209.0, - "partner":"3btr" + "partner":"5hhg" }, { "sim":209.0, @@ -305199,7 +306277,7 @@ }, { "sim":209.0, - "partner":"1y2a" + "partner":"3btr" }, { "sim":209.0, @@ -305209,6 +306287,10 @@ "sim":209.0, "partner":"4zdu" }, + { + "sim":209.0, + "partner":"1y2a" + }, { "sim":209.0, "partner":"6iw8" @@ -305239,27 +306321,23 @@ }, { "sim":209.0, - "partner":"6bwa" - }, - { - "sim":209.0, - "partner":"6bvz" + "partner":"6bvv" }, { "sim":209.0, - "partner":"6bwb" + "partner":"6bw9" }, { "sim":209.0, - "partner":"6bvv" + "partner":"6bwa" }, { "sim":209.0, - "partner":"6bw9" + "partner":"6bvz" }, { "sim":209.0, - "partner":"3zir" + "partner":"6bwb" }, { "sim":209.0, @@ -305283,7 +306361,7 @@ }, { "sim":209.0, - "partner":"4b8p" + "partner":"3zir" }, { "sim":209.0, @@ -305293,6 +306371,10 @@ "sim":209.0, "partner":"4b8o" }, + { + "sim":209.0, + "partner":"4b8p" + }, { "sim":209.0, "partner":"5vqi" @@ -305327,31 +306409,31 @@ }, { "sim":207.0, - "partner":"3q5u" + "partner":"5wun" }, { "sim":207.0, - "partner":"5wum" + "partner":"6p6a" }, { "sim":207.0, - "partner":"5wun" + "partner":"4oih" }, { "sim":207.0, - "partner":"4oih" + "partner":"5x8n" }, { "sim":207.0, - "partner":"6p6a" + "partner":"6p6e" }, { "sim":207.0, - "partner":"5x8n" + "partner":"4yi0" }, { "sim":207.0, - "partner":"6p6e" + "partner":"3knd" }, { "sim":207.0, @@ -305359,31 +306441,31 @@ }, { "sim":207.0, - "partner":"4yi0" + "partner":"1ejy" }, { "sim":207.0, - "partner":"3knd" + "partner":"5b56" }, { "sim":207.0, - "partner":"1ejy" + "partner":"1pjm" }, { "sim":207.0, - "partner":"5b56" + "partner":"1iq1" }, { "sim":207.0, - "partner":"1iq1" + "partner":"1pjn" }, { "sim":207.0, - "partner":"1pjm" + "partner":"3q5u" }, { "sim":207.0, - "partner":"1pjn" + "partner":"5wum" }, { "sim":207.0, @@ -305405,10 +306487,6 @@ "sim":207.0, "partner":"4ba3" }, - { - "sim":207.0, - "partner":"4htv" - }, { "sim":207.0, "partner":"5umz" @@ -305423,19 +306501,7 @@ }, { "sim":207.0, - "partner":"3rzx" - }, - { - "sim":207.0, - "partner":"5e6q" - }, - { - "sim":207.0, - "partner":"3oqs" - }, - { - "sim":207.0, - "partner":"5w4f" + "partner":"4htv" }, { "sim":207.0, @@ -305443,16 +306509,12 @@ }, { "sim":207.0, - "partner":"6bw0" + "partner":"6bw1" }, { "sim":207.0, "partner":"5w4g" }, - { - "sim":207.0, - "partner":"6bw1" - }, { "sim":207.0, "partner":"3ukw" @@ -305503,15 +306565,15 @@ }, { "sim":207.0, - "partner":"3uvu" + "partner":"6bvt" }, { "sim":207.0, - "partner":"5u5r" + "partner":"3uvu" }, { "sim":207.0, - "partner":"6bvt" + "partner":"5u5r" }, { "sim":207.0, @@ -305525,6 +306587,26 @@ "sim":207.0, "partner":"5w4e" }, + { + "sim":207.0, + "partner":"3rzx" + }, + { + "sim":207.0, + "partner":"5e6q" + }, + { + "sim":207.0, + "partner":"3oqs" + }, + { + "sim":207.0, + "partner":"5w4f" + }, + { + "sim":207.0, + "partner":"6bw0" + }, { "sim":207.0, "partner":"5huw" @@ -305668,131 +306750,131 @@ ], "subtitle":"Designed armadillo repeat protein internal lock2 fused to target peptide krkakitwkr", "tags":[ - "peptide binder", "de novo protein", "repeat protein", + "peptide binder", "designed armadillo repeat protein" ], "keywords":[ - "confirm", - "many", - "possibilities", + "role", + "repeat", + "unstructured", "intermolecular", - "specificity", - "analytes", - "selection", - "modules", + "side", + "lead", "acid", - "time", - "peptide", - "determination", - "designed", + "assays", + "short", + "new", + "protein", + "prefer", + "pockets", + "linear", + "proteomes", + "binding", + "confirmed", "register", - "hindering", - "repetitive", - "smaller", - "order", - "sequences", - "f\u00f6rster", - "interactions", - "bind", - "circumventing", + "resonance", "split", - "structure", - "repeat", - "however", + "principle", + "confirm", + "chains", + "away", + "flipping", "solve", - "even", - "lysine", - "middle", - "proteins", "play", - "frequent", - "scalable", - "arginine", - "linear", - "parts", - "assays", - "short", - "elongated", - "yet", - "grafting", - "darmrps", + "select", + "however", + "specificity", + "lysine", + "due", + "determination", "furthermore", - "modularity", - "flipping", - "lead", - "away", - "mutual", - "quest", - "pockets", - "solution", - "assembly", - "resonance", "armadillo", - "role", - "prefer", - "consensus", + "epitopes", "discovered", + "quest", + "middle", + "library", + "elongated", + "optimization", + "analytes", + "bind", + "orthogonal", + "scalable", + "bound", + "proteins", + "modules", + "moved", "rounds", + "consensus", + "modular", + "mutual", + "possibilities", "created", + "computational", + "combination", + "peptide", + "pocket", + "design", + "energy", + "selection", + "selections", + "even", + "yet", + "absence", + "different", + "shifts", + "assembly", "properties", - "classical", - "predefined", - "amino", "carries", - "orthogonal", - "whole", - "thereby", - "proteomes", - "selections", - "optimization", - "specificities", - "would", + "also", + "parts", + "grafting", "sliding", - "transfer", - "design", + "amino", + "solution", + "modularity", + "time", "sequence", - "epitopes", - "energy", - "could", + "system", "retaining", - "preselected", - "important", - "library", - "chains", + "peptides", + "whole", + "desired", + "could", + "designed", + "order", + "sequences", + "many", "one", - "also", - "rational", - "principle", "way", - "desired", - "peptides", - "select", - "reassembled", - "modular", + "classical", + "specificities", + "rational", "moving", - "different", - "confirmed", - "absence", - "problem", - "due", - "system", - "underlining", - "bound", - "protein", - "shifts", - "arbitrary", - "unstructured", - "combination", - "computational", + "important", + "predefined", + "repetitive", + "structure", + "thereby", + "circumventing", + "interactions", + "frequent", + "darmrps", + "hindering", + "f\u00f6rster", + "would", + "reassembled", + "arginine", + "smaller", "diagnostic", - "side", - "pocket", - "binding", - "moved", "libraries", - "new" + "problem", + "arbitrary", + "preselected", + "underlining", + "transfer" ], "release_date":"2020-02-19", "publication":"\"Structure-Guided Design of a Peptide Lock for Modular Peptide Binders\", Acs Chem.Biol., 15, 457-468", @@ -305849,11 +306931,11 @@ }, { "sim":503.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":503.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":503.0, @@ -305865,11 +306947,11 @@ }, { "sim":503.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":503.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":500.0, @@ -305925,11 +307007,11 @@ }, { "sim":282.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":282.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":274.0, @@ -306055,15 +307137,15 @@ }, { "sim":198.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":198.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":198.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":198.0, @@ -306091,11 +307173,11 @@ }, { "sim":197.0, - "partner":"4u5o" + "partner":"3ve6" }, { "sim":197.0, - "partner":"3ve6" + "partner":"6mjl" }, { "sim":197.0, @@ -306105,10 +307187,6 @@ "sim":197.0, "partner":"4u5s" }, - { - "sim":197.0, - "partner":"6mjl" - }, { "sim":197.0, "partner":"4u5u" @@ -306127,7 +307205,7 @@ }, { "sim":197.0, - "partner":"3l3q" + "partner":"4u5o" }, { "sim":197.0, @@ -306135,11 +307213,11 @@ }, { "sim":197.0, - "partner":"5hhg" + "partner":"3l3q" }, { "sim":197.0, - "partner":"3btr" + "partner":"5hhg" }, { "sim":197.0, @@ -306147,7 +307225,7 @@ }, { "sim":197.0, - "partner":"1y2a" + "partner":"3btr" }, { "sim":197.0, @@ -306157,6 +307235,10 @@ "sim":197.0, "partner":"4zdu" }, + { + "sim":197.0, + "partner":"1y2a" + }, { "sim":197.0, "partner":"6iw8" @@ -306179,27 +307261,23 @@ }, { "sim":197.0, - "partner":"6bwa" - }, - { - "sim":197.0, - "partner":"6bvz" + "partner":"6bvv" }, { "sim":197.0, - "partner":"6bwb" + "partner":"6bw9" }, { "sim":197.0, - "partner":"6bvv" + "partner":"6bwa" }, { "sim":197.0, - "partner":"6bw9" + "partner":"6bvz" }, { "sim":197.0, - "partner":"3zir" + "partner":"6bwb" }, { "sim":197.0, @@ -306221,6 +307299,10 @@ "sim":197.0, "partner":"3ziq" }, + { + "sim":197.0, + "partner":"3zir" + }, { "sim":197.0, "partner":"5tbk" @@ -306231,27 +307313,27 @@ }, { "sim":196.0, - "partner":"3q5u" + "partner":"5wun" }, { "sim":196.0, - "partner":"5wum" + "partner":"6p6a" }, { "sim":196.0, - "partner":"5wun" + "partner":"4oih" }, { "sim":196.0, - "partner":"4oih" + "partner":"5x8n" }, { "sim":196.0, - "partner":"6p6a" + "partner":"4yi0" }, { "sim":196.0, - "partner":"5x8n" + "partner":"3knd" }, { "sim":196.0, @@ -306259,31 +307341,31 @@ }, { "sim":196.0, - "partner":"4yi0" + "partner":"1ejy" }, { "sim":196.0, - "partner":"3knd" + "partner":"5b56" }, { "sim":196.0, - "partner":"1ejy" + "partner":"1pjm" }, { "sim":196.0, - "partner":"5b56" + "partner":"1iq1" }, { "sim":196.0, - "partner":"1iq1" + "partner":"1pjn" }, { "sim":196.0, - "partner":"1pjm" + "partner":"3q5u" }, { "sim":196.0, - "partner":"1pjn" + "partner":"5wum" }, { "sim":196.0, @@ -306305,10 +307387,6 @@ "sim":196.0, "partner":"4ba3" }, - { - "sim":196.0, - "partner":"4htv" - }, { "sim":196.0, "partner":"5umz" @@ -306323,19 +307401,7 @@ }, { "sim":196.0, - "partner":"3rzx" - }, - { - "sim":196.0, - "partner":"5e6q" - }, - { - "sim":196.0, - "partner":"3oqs" - }, - { - "sim":196.0, - "partner":"5w4f" + "partner":"4htv" }, { "sim":196.0, @@ -306343,16 +307409,12 @@ }, { "sim":196.0, - "partner":"6bw0" + "partner":"6bw1" }, { "sim":196.0, "partner":"5w4g" }, - { - "sim":196.0, - "partner":"6bw1" - }, { "sim":196.0, "partner":"3ukw" @@ -306403,15 +307465,15 @@ }, { "sim":196.0, - "partner":"3uvu" + "partner":"6bvt" }, { "sim":196.0, - "partner":"5u5r" + "partner":"3uvu" }, { "sim":196.0, - "partner":"6bvt" + "partner":"5u5r" }, { "sim":196.0, @@ -306425,6 +307487,26 @@ "sim":196.0, "partner":"5w4e" }, + { + "sim":196.0, + "partner":"3rzx" + }, + { + "sim":196.0, + "partner":"5e6q" + }, + { + "sim":196.0, + "partner":"3oqs" + }, + { + "sim":196.0, + "partner":"5w4f" + }, + { + "sim":196.0, + "partner":"6bw0" + }, { "sim":196.0, "partner":"5huw" @@ -306585,106 +307667,106 @@ "subtitle":"Darpin-armadillo fusion a5", "tags":[ "armadillo", - "shared helix", - "de novo protein", "protein fusion", "darpin", - "crystallization chaperone" + "de novo protein", + "crystallization chaperone", + "shared helix" ], "keywords":[ - "analysis", - "fusions", + "rigidly", + "repeat", + "key", + "therefore", + "shield", + "well", + "extended", + "new", + "protein", + "binding", + "rapid", + "equilibrium", + "connect", "distorting", - "thus", - "ring", - "crystallography", - "peptide", - "designed", - "geometries", - "robust", + "recognises", "potentially", + "two", "crystal", + "effects", "arginines", - "shared", - "bind", - "expand", - "undistorted", - "dipeptide", - "equilibrium", - "therefore", - "structure", - "repeat", - "truly", - "contacts", - "darmrp", - "generating", - "rigidly", - "chaperone", - "proteins", + "helices", + "robust", "displacing", - "interference", - "strongly", "influence", - "version", - "used", - "serve", - "yet", - "rigid", - "darmrps", - "inside", - "highlighting", - "maintains", - "crystallisation", - "utilised", - "alternating", - "concept", - "construct", - "linked", "armadillo", - "effects", - "consensus", - "previously", - "rapid", - "per", - "predefined", - "recognises", - "geometry", - "crystallising", - "extended", - "darpins", - "specificities", + "overall", + "thus", + "maintains", + "rigid", "fused", - "mode", + "ring", + "disulfide", + "contacts", + "strongly", + "bind", "useful", - "lysines", - "connect", - "design", + "proteins", + "consensus", + "modular", + "described", + "ankyrin", + "undistorted", + "scaffold", + "dipeptide", + "found", "bond", + "linked", + "construct", "required", + "peptide", + "crystallisation", + "geometries", "surface", - "key", - "disulfide", - "overall", - "one", - "helices", + "design", + "used", + "yet", + "chaperone", "also", - "described", - "way", + "lysines", + "minimise", + "alternating", + "mode", + "highlighting", + "interference", + "crystallising", "peptides", - "modular", - "well", - "ankyrin", - "found", - "two", + "expand", + "utilised", + "generating", + "truly", + "darpins", + "per", + "shared", + "chimeric", + "designed", + "analysis", + "fusions", + "one", + "way", + "geometry", + "specificities", + "previously", + "concept", + "structure", + "predefined", + "serve", + "crystallography", "prevents", - "scaffold", - "binding", - "protein", + "darmrps", + "inside", + "version", "regular", - "shield", - "chimeric", - "minimise", - "new" + "darmrp" ], "release_date":"2019-11-20", "publication":"\"Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts\", Sci Rep, 9, 16162-16162", @@ -306737,11 +307819,11 @@ }, { "sim":409.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":409.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":409.0, @@ -306753,11 +307835,11 @@ }, { "sim":409.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":409.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":409.0, @@ -306849,7 +307931,7 @@ }, { "sim":296.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":296.0, @@ -306857,7 +307939,7 @@ }, { "sim":296.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":285.0, @@ -306877,11 +307959,11 @@ }, { "sim":261.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":261.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":243.0, @@ -306969,47 +308051,47 @@ }, { "sim":222.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":222.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":222.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":222.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":222.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":222.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":222.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":222.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":222.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":222.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":222.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":222.0, @@ -307017,15 +308099,15 @@ }, { "sim":222.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":222.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":222.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":222.0, @@ -307089,11 +308171,11 @@ }, { "sim":204.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":204.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":204.0, @@ -307117,11 +308199,11 @@ }, { "sim":177.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":177.0, - "partner":"4qfv" + "partner":"4o60" }, { "sim":177.0, @@ -307129,16 +308211,20 @@ }, { "sim":176.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":176.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":175.0, "partner":"8ak1" }, + { + "sim":171.0, + "partner":"9glq" + }, { "sim":171.0, "partner":"8rci" @@ -307177,11 +308263,11 @@ }, { "sim":162.0, - "partner":"4gpm" + "partner":"4hb5" }, { "sim":162.0, - "partner":"4hb5" + "partner":"4gpm" }, { "sim":160.0, @@ -307291,11 +308377,11 @@ }, { "sim":237.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":237.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":237.0, @@ -307339,11 +308425,11 @@ }, { "sim":229.0, - "partner":"5oyj" + "partner":"2y1l" }, { "sim":229.0, - "partner":"2y1l" + "partner":"5oyj" }, { "sim":228.0, @@ -307401,29 +308487,21 @@ "sim":224.0, "partner":"6qev" }, - { - "sim":223.0, - "partner":"5eno" - }, { "sim":223.0, "partner":"4dx6" }, - { - "sim":223.0, - "partner":"6q4n" - }, { "sim":223.0, "partner":"5enp" }, { "sim":223.0, - "partner":"4dx7" + "partner":"6q4o" }, { "sim":223.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":223.0, @@ -307485,6 +308563,14 @@ "sim":223.0, "partner":"4dx5" }, + { + "sim":223.0, + "partner":"5eno" + }, + { + "sim":223.0, + "partner":"6q4n" + }, { "sim":223.0, "partner":"6nht" @@ -307507,11 +308593,11 @@ }, { "sim":222.0, - "partner":"5nqt" + "partner":"6mze" }, { "sim":222.0, - "partner":"6mze" + "partner":"5nqt" }, { "sim":222.0, @@ -307639,11 +308725,11 @@ }, { "sim":203.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":203.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":203.0, @@ -307687,11 +308773,11 @@ }, { "sim":184.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":184.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":176.0, @@ -307719,15 +308805,15 @@ }, { "sim":165.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":165.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":165.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":165.0, @@ -307787,15 +308873,15 @@ }, { "sim":160.0, - "partner":"4pvz" + "partner":"1bk5" }, { "sim":160.0, - "partner":"1bk5" + "partner":"1bk6" }, { "sim":160.0, - "partner":"1bk6" + "partner":"4pvz" }, { "sim":160.0, @@ -307843,11 +308929,11 @@ }, { "sim":159.0, - "partner":"4u5o" + "partner":"3ve6" }, { "sim":159.0, - "partner":"3ve6" + "partner":"6mjl" }, { "sim":159.0, @@ -307857,10 +308943,6 @@ "sim":159.0, "partner":"4u5s" }, - { - "sim":159.0, - "partner":"6mjl" - }, { "sim":159.0, "partner":"4u5u" @@ -307879,7 +308961,7 @@ }, { "sim":159.0, - "partner":"3l3q" + "partner":"4u5o" }, { "sim":159.0, @@ -307887,11 +308969,11 @@ }, { "sim":159.0, - "partner":"5hhg" + "partner":"3l3q" }, { "sim":159.0, - "partner":"3btr" + "partner":"5hhg" }, { "sim":159.0, @@ -307899,7 +308981,7 @@ }, { "sim":159.0, - "partner":"1y2a" + "partner":"3btr" }, { "sim":159.0, @@ -307909,6 +308991,10 @@ "sim":159.0, "partner":"4zdu" }, + { + "sim":159.0, + "partner":"1y2a" + }, { "sim":159.0, "partner":"6iw8" @@ -307929,10 +309015,6 @@ "sim":159.0, "partner":"1ial" }, - { - "sim":159.0, - "partner":"3zir" - }, { "sim":159.0, "partner":"2ynr" @@ -307954,16 +309036,12 @@ "partner":"3ziq" }, { - "sim":158.0, - "partner":"5k9s" - }, - { - "sim":158.0, - "partner":"3q5u" + "sim":159.0, + "partner":"3zir" }, { "sim":158.0, - "partner":"5wum" + "partner":"5k9s" }, { "sim":158.0, @@ -307979,15 +309057,15 @@ }, { "sim":158.0, - "partner":"1ejl" + "partner":"4yi0" }, { "sim":158.0, - "partner":"4yi0" + "partner":"3knd" }, { "sim":158.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":158.0, @@ -307999,16 +309077,24 @@ }, { "sim":158.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":158.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":158.0, "partner":"1pjn" }, + { + "sim":158.0, + "partner":"3q5u" + }, + { + "sim":158.0, + "partner":"5wum" + }, { "sim":158.0, "partner":"4uaf" @@ -308029,10 +309115,6 @@ "sim":158.0, "partner":"4ba3" }, - { - "sim":158.0, - "partner":"4htv" - }, { "sim":158.0, "partner":"5umz" @@ -308047,23 +309129,7 @@ }, { "sim":158.0, - "partner":"3rzx" - }, - { - "sim":158.0, - "partner":"5e6q" - }, - { - "sim":158.0, - "partner":"3oqs" - }, - { - "sim":158.0, - "partner":"5w4f" - }, - { - "sim":158.0, - "partner":"6d7m" + "partner":"4htv" }, { "sim":158.0, @@ -308071,16 +309137,12 @@ }, { "sim":158.0, - "partner":"6bw0" + "partner":"6bw1" }, { "sim":158.0, "partner":"5w4g" }, - { - "sim":158.0, - "partner":"6bw1" - }, { "sim":158.0, "partner":"3ukw" @@ -308131,15 +309193,15 @@ }, { "sim":158.0, - "partner":"3uvu" + "partner":"6bvt" }, { "sim":158.0, - "partner":"5u5r" + "partner":"3uvu" }, { "sim":158.0, - "partner":"6bvt" + "partner":"5u5r" }, { "sim":158.0, @@ -308153,6 +309215,30 @@ "sim":158.0, "partner":"5w4e" }, + { + "sim":158.0, + "partner":"3rzx" + }, + { + "sim":158.0, + "partner":"5e6q" + }, + { + "sim":158.0, + "partner":"6d7m" + }, + { + "sim":158.0, + "partner":"3oqs" + }, + { + "sim":158.0, + "partner":"5w4f" + }, + { + "sim":158.0, + "partner":"6bw0" + }, { "sim":158.0, "partner":"5huw" @@ -308199,23 +309285,23 @@ }, { "sim":156.0, - "partner":"6bwa" + "partner":"6bvv" }, { "sim":156.0, - "partner":"6bvz" + "partner":"6bw9" }, { "sim":156.0, - "partner":"6bwb" + "partner":"6bwa" }, { "sim":156.0, - "partner":"6bvv" + "partner":"6bvz" }, { "sim":156.0, - "partner":"6bw9" + "partner":"6bwb" }, { "sim":156.0, @@ -308389,17 +309475,13 @@ "sim":105.0, "partner":"5jhq" }, - { - "sim":98.0, - "partner":"4cym" - }, { "sim":98.0, "partner":"4cz2" }, { - "sim":97.0, - "partner":"5vhj" + "sim":98.0, + "partner":"4cym" }, { "sim":97.0, @@ -308429,6 +309511,10 @@ "sim":97.0, "partner":"5vho" }, + { + "sim":97.0, + "partner":"5vhj" + }, { "sim":97.0, "partner":"5vhp" @@ -308455,15 +309541,15 @@ }, { "sim":97.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":97.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":97.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":97.0, @@ -308659,35 +309745,35 @@ }, { "sim":82.0, - "partner":"1m1e" + "partner":"1v18" }, { "sim":82.0, - "partner":"4evt" + "partner":"4ev8" }, { "sim":82.0, - "partner":"1v18" + "partner":"4ev9" }, { "sim":82.0, - "partner":"4ev8" + "partner":"4evp" }, { "sim":82.0, - "partner":"1i7w" + "partner":"4eva" }, { "sim":82.0, - "partner":"4ev9" + "partner":"1i7w" }, { "sim":82.0, - "partner":"4evp" + "partner":"1m1e" }, { "sim":82.0, - "partner":"4eva" + "partner":"4evt" }, { "sim":82.0, @@ -308887,11 +309973,11 @@ }, { "sim":68.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":68.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":67.0, @@ -308931,15 +310017,15 @@ }, { "sim":64.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":64.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":64.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":63.0, @@ -309001,10 +310087,6 @@ "sim":55.0, "partner":"5wo6" }, - { - "sim":55.0, - "partner":"5iwr" - }, { "sim":55.0, "partner":"5iwt" @@ -309055,11 +310137,11 @@ }, { "sim":55.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":55.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":55.0, @@ -309097,6 +310179,10 @@ "sim":55.0, "partner":"6dmw" }, + { + "sim":55.0, + "partner":"6o1p" + }, { "sim":54.0, "partner":"8pef" @@ -309133,6 +310219,10 @@ "sim":53.0, "partner":"4bet" }, + { + "sim":52.0, + "partner":"8ycp" + }, { "sim":51.0, "partner":"3deo" @@ -309229,106 +310319,106 @@ "subtitle":"Darpin-armadillo fusion c8long83", "tags":[ "armadillo", - "shared helix", - "de novo protein", "protein fusion", "darpin", - "crystallization chaperone" + "de novo protein", + "crystallization chaperone", + "shared helix" ], "keywords":[ - "analysis", - "fusions", + "rigidly", + "repeat", + "key", + "therefore", + "shield", + "well", + "extended", + "new", + "protein", + "binding", + "rapid", + "equilibrium", + "connect", "distorting", - "thus", - "ring", - "crystallography", - "peptide", - "designed", - "geometries", - "robust", + "recognises", "potentially", + "two", "crystal", + "effects", "arginines", - "shared", - "bind", - "expand", - "undistorted", - "dipeptide", - "equilibrium", - "therefore", - "structure", - "repeat", - "truly", - "contacts", - "darmrp", - "generating", - "rigidly", - "chaperone", - "proteins", + "helices", + "robust", "displacing", - "interference", - "strongly", "influence", - "version", - "used", - "serve", - "yet", - "rigid", - "darmrps", - "inside", - "highlighting", - "maintains", - "crystallisation", - "utilised", - "alternating", - "concept", - "construct", - "linked", "armadillo", - "effects", - "consensus", - "previously", - "rapid", - "per", - "predefined", - "recognises", - "geometry", - "crystallising", - "extended", - "darpins", - "specificities", + "overall", + "thus", + "maintains", + "rigid", "fused", - "mode", + "ring", + "disulfide", + "contacts", + "strongly", + "bind", "useful", - "lysines", - "connect", - "design", + "proteins", + "consensus", + "modular", + "described", + "ankyrin", + "undistorted", + "scaffold", + "dipeptide", + "found", "bond", + "linked", + "construct", "required", + "peptide", + "crystallisation", + "geometries", "surface", - "key", - "disulfide", - "overall", - "one", - "helices", + "design", + "used", + "yet", + "chaperone", "also", - "described", - "way", + "lysines", + "minimise", + "alternating", + "mode", + "highlighting", + "interference", + "crystallising", "peptides", - "modular", - "well", - "ankyrin", - "found", - "two", + "expand", + "utilised", + "generating", + "truly", + "darpins", + "per", + "shared", + "chimeric", + "designed", + "analysis", + "fusions", + "one", + "way", + "geometry", + "specificities", + "previously", + "concept", + "structure", + "predefined", + "serve", + "crystallography", "prevents", - "scaffold", - "binding", - "protein", + "darmrps", + "inside", + "version", "regular", - "shield", - "chimeric", - "minimise", - "new" + "darmrp" ], "release_date":"2019-11-20", "publication":"\"Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts\", Sci Rep, 9, 16162-16162", @@ -309385,11 +310475,11 @@ }, { "sim":499.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":499.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":499.0, @@ -309401,11 +310491,11 @@ }, { "sim":499.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":499.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":490.0, @@ -309493,7 +310583,7 @@ }, { "sim":299.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":299.0, @@ -309501,7 +310591,7 @@ }, { "sim":299.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":295.0, @@ -309521,11 +310611,11 @@ }, { "sim":282.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":282.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":261.0, @@ -309625,47 +310715,47 @@ }, { "sim":232.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":232.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":232.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":232.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":232.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":232.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":232.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":232.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":232.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":232.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":232.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":232.0, @@ -309673,15 +310763,15 @@ }, { "sim":232.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":232.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":232.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":231.0, @@ -309741,11 +310831,11 @@ }, { "sim":213.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":213.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":213.0, @@ -309773,19 +310863,19 @@ }, { "sim":185.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":185.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":184.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":184.0, - "partner":"4qfv" + "partner":"4o60" }, { "sim":179.0, @@ -309819,6 +310909,10 @@ "sim":173.0, "partner":"4hb5" }, + { + "sim":171.0, + "partner":"9glq" + }, { "sim":169.0, "partner":"2jab" @@ -309829,11 +310923,11 @@ }, { "sim":167.0, - "partner":"9f24" + "partner":"8aiw" }, { "sim":167.0, - "partner":"8aiw" + "partner":"9f24" }, { "sim":165.0, @@ -309939,11 +311033,11 @@ }, { "sim":246.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":246.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":246.0, @@ -309987,11 +311081,11 @@ }, { "sim":239.0, - "partner":"5oyj" + "partner":"2y1l" }, { "sim":239.0, - "partner":"2y1l" + "partner":"5oyj" }, { "sim":238.0, @@ -310041,29 +311135,21 @@ "sim":234.0, "partner":"6qev" }, - { - "sim":233.0, - "partner":"5eno" - }, { "sim":233.0, "partner":"4dx6" }, - { - "sim":233.0, - "partner":"6q4n" - }, { "sim":233.0, "partner":"5enp" }, { "sim":233.0, - "partner":"4dx7" + "partner":"6q4o" }, { "sim":233.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":233.0, @@ -310125,6 +311211,14 @@ "sim":233.0, "partner":"4dx5" }, + { + "sim":233.0, + "partner":"5eno" + }, + { + "sim":233.0, + "partner":"6q4n" + }, { "sim":233.0, "partner":"5mlb" @@ -310151,11 +311245,11 @@ }, { "sim":232.0, - "partner":"5nqt" + "partner":"6mze" }, { "sim":232.0, - "partner":"6mze" + "partner":"5nqt" }, { "sim":232.0, @@ -310327,23 +311421,23 @@ }, { "sim":217.0, - "partner":"6bwa" + "partner":"6bvv" }, { "sim":217.0, - "partner":"6bvz" + "partner":"6bw9" }, { "sim":217.0, - "partner":"6bwb" + "partner":"6bwa" }, { "sim":217.0, - "partner":"6bvv" + "partner":"6bvz" }, { "sim":217.0, - "partner":"6bw9" + "partner":"6bwb" }, { "sim":217.0, @@ -310359,7 +311453,7 @@ }, { "sim":216.0, - "partner":"4pvz" + "partner":"3tpm" }, { "sim":216.0, @@ -310367,7 +311461,7 @@ }, { "sim":216.0, - "partner":"3tpm" + "partner":"4pvz" }, { "sim":216.0, @@ -310391,11 +311485,11 @@ }, { "sim":216.0, - "partner":"4u5o" + "partner":"3ve6" }, { "sim":216.0, - "partner":"3ve6" + "partner":"6mjl" }, { "sim":216.0, @@ -310405,10 +311499,6 @@ "sim":216.0, "partner":"4u5s" }, - { - "sim":216.0, - "partner":"6mjl" - }, { "sim":216.0, "partner":"4u5u" @@ -310427,7 +311517,7 @@ }, { "sim":216.0, - "partner":"3l3q" + "partner":"4u5o" }, { "sim":216.0, @@ -310435,11 +311525,11 @@ }, { "sim":216.0, - "partner":"5hhg" + "partner":"3l3q" }, { "sim":216.0, - "partner":"3btr" + "partner":"5hhg" }, { "sim":216.0, @@ -310447,7 +311537,7 @@ }, { "sim":216.0, - "partner":"1y2a" + "partner":"3btr" }, { "sim":216.0, @@ -310457,6 +311547,10 @@ "sim":216.0, "partner":"4zdu" }, + { + "sim":216.0, + "partner":"1y2a" + }, { "sim":216.0, "partner":"6iw8" @@ -310485,10 +311579,6 @@ "sim":216.0, "partner":"4bqk" }, - { - "sim":216.0, - "partner":"3zir" - }, { "sim":216.0, "partner":"2ynr" @@ -310511,7 +311601,7 @@ }, { "sim":216.0, - "partner":"4b8p" + "partner":"3zir" }, { "sim":216.0, @@ -310521,6 +311611,10 @@ "sim":216.0, "partner":"4b8o" }, + { + "sim":216.0, + "partner":"4b8p" + }, { "sim":216.0, "partner":"4b8j" @@ -310547,23 +311641,23 @@ }, { "sim":214.0, - "partner":"3q5u" + "partner":"5wun" }, { "sim":214.0, - "partner":"5wum" + "partner":"4oih" }, { "sim":214.0, - "partner":"5wun" + "partner":"5x8n" }, { "sim":214.0, - "partner":"4oih" + "partner":"4yi0" }, { "sim":214.0, - "partner":"5x8n" + "partner":"3knd" }, { "sim":214.0, @@ -310571,31 +311665,31 @@ }, { "sim":214.0, - "partner":"4yi0" + "partner":"1ejy" }, { "sim":214.0, - "partner":"3knd" + "partner":"5b56" }, { "sim":214.0, - "partner":"1ejy" + "partner":"1pjm" }, { "sim":214.0, - "partner":"5b56" + "partner":"1iq1" }, { "sim":214.0, - "partner":"1iq1" + "partner":"1pjn" }, { "sim":214.0, - "partner":"1pjm" + "partner":"3q5u" }, { "sim":214.0, - "partner":"1pjn" + "partner":"5wum" }, { "sim":214.0, @@ -310617,10 +311711,6 @@ "sim":214.0, "partner":"4ba3" }, - { - "sim":214.0, - "partner":"4htv" - }, { "sim":214.0, "partner":"5umz" @@ -310635,19 +311725,7 @@ }, { "sim":214.0, - "partner":"3rzx" - }, - { - "sim":214.0, - "partner":"5e6q" - }, - { - "sim":214.0, - "partner":"3oqs" - }, - { - "sim":214.0, - "partner":"5w4f" + "partner":"4htv" }, { "sim":214.0, @@ -310655,16 +311733,12 @@ }, { "sim":214.0, - "partner":"6bw0" + "partner":"6bw1" }, { "sim":214.0, "partner":"5w4g" }, - { - "sim":214.0, - "partner":"6bw1" - }, { "sim":214.0, "partner":"3ukw" @@ -310715,15 +311789,15 @@ }, { "sim":214.0, - "partner":"3uvu" + "partner":"6bvt" }, { "sim":214.0, - "partner":"5u5r" + "partner":"3uvu" }, { "sim":214.0, - "partner":"6bvt" + "partner":"5u5r" }, { "sim":214.0, @@ -310737,6 +311811,26 @@ "sim":214.0, "partner":"5w4e" }, + { + "sim":214.0, + "partner":"3rzx" + }, + { + "sim":214.0, + "partner":"5e6q" + }, + { + "sim":214.0, + "partner":"3oqs" + }, + { + "sim":214.0, + "partner":"5w4f" + }, + { + "sim":214.0, + "partner":"6bw0" + }, { "sim":214.0, "partner":"5huw" @@ -310759,11 +311853,11 @@ }, { "sim":211.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":211.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":211.0, @@ -310831,11 +311925,11 @@ }, { "sim":196.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":196.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":193.0, @@ -311087,35 +312181,35 @@ }, { "sim":106.0, - "partner":"1m1e" + "partner":"1v18" }, { "sim":106.0, - "partner":"4evt" + "partner":"4ev8" }, { "sim":106.0, - "partner":"1v18" + "partner":"4ev9" }, { "sim":106.0, - "partner":"4ev8" + "partner":"4evp" }, { "sim":106.0, - "partner":"1i7w" + "partner":"4eva" }, { "sim":106.0, - "partner":"4ev9" + "partner":"1i7w" }, { "sim":106.0, - "partner":"4evp" + "partner":"1m1e" }, { "sim":106.0, - "partner":"4eva" + "partner":"4evt" }, { "sim":106.0, @@ -311149,10 +312243,6 @@ "sim":104.0, "partner":"6by9" }, - { - "sim":103.0, - "partner":"5vhj" - }, { "sim":103.0, "partner":"5vhh" @@ -311181,6 +312271,10 @@ "sim":103.0, "partner":"5vho" }, + { + "sim":103.0, + "partner":"5vhj" + }, { "sim":103.0, "partner":"5vhp" @@ -311207,15 +312301,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":100.0, @@ -311227,11 +312321,11 @@ }, { "sim":98.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":98.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":94.0, @@ -311575,11 +312669,11 @@ }, { "sim":68.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":68.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":68.0, @@ -311603,15 +312697,15 @@ }, { "sim":64.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":64.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":64.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":64.0, @@ -311649,10 +312743,6 @@ "sim":59.0, "partner":"5wo6" }, - { - "sim":59.0, - "partner":"5iwr" - }, { "sim":59.0, "partner":"5iwt" @@ -311703,11 +312793,11 @@ }, { "sim":59.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":59.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":59.0, @@ -311745,6 +312835,10 @@ "sim":59.0, "partner":"6dmw" }, + { + "sim":59.0, + "partner":"6o1p" + }, { "sim":58.0, "partner":"6emk" @@ -311809,10 +312903,6 @@ "sim":53.0, "partner":"6e2f" }, - { - "sim":53.0, - "partner":"6bo9" - }, { "sim":53.0, "partner":"6boa" @@ -311829,6 +312919,14 @@ "sim":53.0, "partner":"6bo8" }, + { + "sim":53.0, + "partner":"6bo9" + }, + { + "sim":52.0, + "partner":"8ycp" + }, { "sim":51.0, "partner":"3deo" @@ -311855,18 +312953,6 @@ "sim":0.9516000152, "partner":"7b4w" }, - { - "sim":0.9556999803, - "partner":"7z7e" - }, - { - "sim":0.9562000036, - "partner":"7z7c" - }, - { - "sim":0.951399982, - "partner":"4j8y" - }, { "sim":0.9534999728, "partner":"2xeh" @@ -311879,6 +312965,14 @@ "sim":0.9552000165, "partner":"2xee" }, + { + "sim":0.9556999803, + "partner":"7z7e" + }, + { + "sim":0.9562000036, + "partner":"7z7c" + }, { "sim":0.9538000226, "partner":"7z71" @@ -311894,9 +312988,17 @@ { "sim":0.9516000152, "partner":"5kng" + }, + { + "sim":0.951399982, + "partner":"4j8y" } ], "struct_thr_sim_natural":[ + { + "sim":0.9609000087, + "partner":"4k5a" + }, { "sim":0.951399982, "partner":"5mfm" @@ -311905,10 +313007,6 @@ "sim":0.9559999704, "partner":"5fin" }, - { - "sim":0.9609000087, - "partner":"4k5a" - }, { "sim":0.950699985, "partner":"4ydy" @@ -311995,106 +313093,106 @@ "subtitle":"Ring-like darpin-armadillo fusion h83_d01", "tags":[ "armadillo", - "shared helix", - "de novo protein", "protein fusion", "darpin", - "crystallization chaperone" + "de novo protein", + "crystallization chaperone", + "shared helix" ], "keywords":[ - "analysis", - "fusions", + "rigidly", + "repeat", + "key", + "therefore", + "shield", + "well", + "extended", + "new", + "protein", + "binding", + "rapid", + "equilibrium", + "connect", "distorting", - "thus", - "ring", - "crystallography", - "peptide", - "designed", - "geometries", - "robust", + "recognises", "potentially", + "two", "crystal", + "effects", "arginines", - "shared", - "bind", - "expand", - "undistorted", - "dipeptide", - "equilibrium", - "therefore", - "structure", - "repeat", - "truly", - "contacts", - "darmrp", - "generating", - "rigidly", - "chaperone", - "proteins", + "helices", + "robust", "displacing", - "interference", - "strongly", "influence", - "version", - "used", - "serve", - "yet", - "rigid", - "darmrps", - "inside", - "highlighting", - "maintains", - "crystallisation", - "utilised", - "alternating", - "concept", - "construct", - "linked", "armadillo", - "effects", - "consensus", - "previously", - "rapid", - "per", - "predefined", - "recognises", - "geometry", - "crystallising", - "extended", - "darpins", - "specificities", + "overall", + "thus", + "maintains", + "rigid", "fused", - "mode", + "ring", + "disulfide", + "contacts", + "strongly", + "bind", "useful", - "lysines", - "connect", - "design", + "proteins", + "consensus", + "modular", + "described", + "ankyrin", + "undistorted", + "scaffold", + "dipeptide", + "found", "bond", + "linked", + "construct", "required", + "peptide", + "crystallisation", + "geometries", "surface", - "key", - "disulfide", - "overall", - "one", - "helices", + "design", + "used", + "yet", + "chaperone", "also", - "described", - "way", + "lysines", + "minimise", + "alternating", + "mode", + "highlighting", + "interference", + "crystallising", "peptides", - "modular", - "well", - "ankyrin", - "found", - "two", + "expand", + "utilised", + "generating", + "truly", + "darpins", + "per", + "shared", + "chimeric", + "designed", + "analysis", + "fusions", + "one", + "way", + "geometry", + "specificities", + "previously", + "concept", + "structure", + "predefined", + "serve", + "crystallography", "prevents", - "scaffold", - "binding", - "protein", + "darmrps", + "inside", + "version", "regular", - "shield", - "chimeric", - "minimise", - "new" + "darmrp" ], "release_date":"2019-11-20", "publication":"\"Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts\", Sci Rep, 9, 16162-16162", @@ -312155,7 +313253,7 @@ }, { "sim":507.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":507.0, @@ -312163,7 +313261,7 @@ }, { "sim":507.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":504.0, @@ -312171,11 +313269,11 @@ }, { "sim":462.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":462.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":462.0, @@ -312187,11 +313285,11 @@ }, { "sim":462.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":462.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":453.0, @@ -312211,11 +313309,11 @@ }, { "sim":435.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":435.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":434.0, @@ -312287,11 +313385,11 @@ }, { "sim":278.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":278.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":276.0, @@ -312387,47 +313485,47 @@ }, { "sim":228.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":228.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":228.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":228.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":228.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":228.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":228.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":228.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":228.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":228.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":228.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":228.0, @@ -312435,15 +313533,15 @@ }, { "sim":228.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":228.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":228.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":228.0, @@ -312475,11 +313573,11 @@ }, { "sim":224.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":224.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":224.0, @@ -312551,11 +313649,11 @@ }, { "sim":178.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":178.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":175.0, @@ -312585,6 +313683,10 @@ "sim":171.0, "partner":"4hb5" }, + { + "sim":168.0, + "partner":"9glq" + }, { "sim":168.0, "partner":"4gpm" @@ -312765,11 +313867,11 @@ }, { "sim":235.0, - "partner":"5oyj" + "partner":"2y1l" }, { "sim":235.0, - "partner":"2y1l" + "partner":"5oyj" }, { "sim":234.0, @@ -312839,29 +313941,21 @@ "sim":231.0, "partner":"5o2s" }, - { - "sim":229.0, - "partner":"5eno" - }, { "sim":229.0, "partner":"4dx6" }, - { - "sim":229.0, - "partner":"6q4n" - }, { "sim":229.0, "partner":"5enp" }, { "sim":229.0, - "partner":"4dx7" + "partner":"6q4o" }, { "sim":229.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":229.0, @@ -312923,6 +314017,14 @@ "sim":229.0, "partner":"4dx5" }, + { + "sim":229.0, + "partner":"5eno" + }, + { + "sim":229.0, + "partner":"6q4n" + }, { "sim":229.0, "partner":"5mla" @@ -312945,11 +314047,11 @@ }, { "sim":228.0, - "partner":"5nqt" + "partner":"6mze" }, { "sim":228.0, - "partner":"6mze" + "partner":"5nqt" }, { "sim":228.0, @@ -313045,15 +314147,15 @@ }, { "sim":222.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":222.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":222.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":222.0, @@ -313089,15 +314191,15 @@ }, { "sim":219.0, - "partner":"4pvz" + "partner":"1bk5" }, { "sim":219.0, - "partner":"1bk5" + "partner":"1bk6" }, { "sim":219.0, - "partner":"1bk6" + "partner":"4pvz" }, { "sim":219.0, @@ -313181,11 +314283,11 @@ }, { "sim":213.0, - "partner":"4u5o" + "partner":"3ve6" }, { "sim":213.0, - "partner":"3ve6" + "partner":"6mjl" }, { "sim":213.0, @@ -313195,10 +314297,6 @@ "sim":213.0, "partner":"4u5s" }, - { - "sim":213.0, - "partner":"6mjl" - }, { "sim":213.0, "partner":"4u5u" @@ -313217,7 +314315,7 @@ }, { "sim":213.0, - "partner":"3l3q" + "partner":"4u5o" }, { "sim":213.0, @@ -313225,11 +314323,11 @@ }, { "sim":213.0, - "partner":"5hhg" + "partner":"3l3q" }, { "sim":213.0, - "partner":"3btr" + "partner":"5hhg" }, { "sim":213.0, @@ -313237,7 +314335,7 @@ }, { "sim":213.0, - "partner":"1y2a" + "partner":"3btr" }, { "sim":213.0, @@ -313247,6 +314345,10 @@ "sim":213.0, "partner":"4zdu" }, + { + "sim":213.0, + "partner":"1y2a" + }, { "sim":213.0, "partner":"5h43" @@ -313275,14 +314377,6 @@ "sim":213.0, "partner":"5k9s" }, - { - "sim":213.0, - "partner":"3q5u" - }, - { - "sim":213.0, - "partner":"5wum" - }, { "sim":213.0, "partner":"5wun" @@ -313297,15 +314391,15 @@ }, { "sim":213.0, - "partner":"1ejl" + "partner":"4yi0" }, { "sim":213.0, - "partner":"4yi0" + "partner":"3knd" }, { "sim":213.0, - "partner":"3knd" + "partner":"1ejl" }, { "sim":213.0, @@ -313317,11 +314411,11 @@ }, { "sim":213.0, - "partner":"1iq1" + "partner":"1pjm" }, { "sim":213.0, - "partner":"1pjm" + "partner":"1iq1" }, { "sim":213.0, @@ -313329,7 +314423,11 @@ }, { "sim":213.0, - "partner":"3zir" + "partner":"3q5u" + }, + { + "sim":213.0, + "partner":"5wum" }, { "sim":213.0, @@ -313351,6 +314449,10 @@ "sim":213.0, "partner":"3ziq" }, + { + "sim":213.0, + "partner":"3zir" + }, { "sim":213.0, "partner":"4uaf" @@ -313371,10 +314473,6 @@ "sim":213.0, "partner":"4ba3" }, - { - "sim":213.0, - "partner":"4htv" - }, { "sim":213.0, "partner":"5umz" @@ -313389,19 +314487,7 @@ }, { "sim":213.0, - "partner":"3rzx" - }, - { - "sim":213.0, - "partner":"5e6q" - }, - { - "sim":213.0, - "partner":"3oqs" - }, - { - "sim":213.0, - "partner":"5w4f" + "partner":"4htv" }, { "sim":213.0, @@ -313409,16 +314495,12 @@ }, { "sim":213.0, - "partner":"6bw0" + "partner":"6bw1" }, { "sim":213.0, "partner":"5w4g" }, - { - "sim":213.0, - "partner":"6bw1" - }, { "sim":213.0, "partner":"3ukw" @@ -313469,15 +314551,15 @@ }, { "sim":213.0, - "partner":"3uvu" + "partner":"6bvt" }, { "sim":213.0, - "partner":"5u5r" + "partner":"3uvu" }, { "sim":213.0, - "partner":"6bvt" + "partner":"5u5r" }, { "sim":213.0, @@ -313491,6 +314573,26 @@ "sim":213.0, "partner":"5w4e" }, + { + "sim":213.0, + "partner":"3rzx" + }, + { + "sim":213.0, + "partner":"5e6q" + }, + { + "sim":213.0, + "partner":"3oqs" + }, + { + "sim":213.0, + "partner":"5w4f" + }, + { + "sim":213.0, + "partner":"6bw0" + }, { "sim":213.0, "partner":"5huw" @@ -313521,11 +314623,11 @@ }, { "sim":208.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":208.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":208.0, @@ -313545,23 +314647,23 @@ }, { "sim":205.0, - "partner":"6bwa" + "partner":"6bvv" }, { "sim":205.0, - "partner":"6bvz" + "partner":"6bw9" }, { "sim":205.0, - "partner":"6bwb" + "partner":"6bwa" }, { "sim":205.0, - "partner":"6bvv" + "partner":"6bvz" }, { "sim":205.0, - "partner":"6bw9" + "partner":"6bwb" }, { "sim":205.0, @@ -313613,11 +314715,11 @@ }, { "sim":192.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":192.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":188.0, @@ -313853,35 +314955,35 @@ }, { "sim":108.0, - "partner":"1m1e" + "partner":"1v18" }, { "sim":108.0, - "partner":"4evt" + "partner":"4ev8" }, { "sim":108.0, - "partner":"1v18" + "partner":"4ev9" }, { "sim":108.0, - "partner":"4ev8" + "partner":"4evp" }, { "sim":108.0, - "partner":"1i7w" + "partner":"4eva" }, { "sim":108.0, - "partner":"4ev9" + "partner":"1i7w" }, { "sim":108.0, - "partner":"4evp" + "partner":"1m1e" }, { "sim":108.0, - "partner":"4eva" + "partner":"4evt" }, { "sim":108.0, @@ -313915,10 +315017,6 @@ "sim":104.0, "partner":"6by9" }, - { - "sim":103.0, - "partner":"5vhj" - }, { "sim":103.0, "partner":"5vhh" @@ -313947,6 +315045,10 @@ "sim":103.0, "partner":"5vho" }, + { + "sim":103.0, + "partner":"5vhj" + }, { "sim":103.0, "partner":"5vhp" @@ -313977,15 +315079,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":101.0, @@ -313997,11 +315099,11 @@ }, { "sim":98.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":98.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":98.0, @@ -314345,11 +315447,11 @@ }, { "sim":68.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":68.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":68.0, @@ -314373,15 +315475,15 @@ }, { "sim":64.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":64.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":64.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":64.0, @@ -314395,10 +315497,6 @@ "sim":64.0, "partner":"5wo6" }, - { - "sim":64.0, - "partner":"5iwr" - }, { "sim":64.0, "partner":"5iwt" @@ -314447,6 +315545,10 @@ "sim":64.0, "partner":"5iwp" }, + { + "sim":64.0, + "partner":"5iwr" + }, { "sim":64.0, "partner":"5wo7" @@ -314475,10 +315577,6 @@ "sim":59.0, "partner":"4hbd" }, - { - "sim":59.0, - "partner":"6o1p" - }, { "sim":59.0, "partner":"6b5v" @@ -314515,6 +315613,10 @@ "sim":59.0, "partner":"6dmw" }, + { + "sim":59.0, + "partner":"6o1p" + }, { "sim":58.0, "partner":"8pef" @@ -314551,10 +315653,6 @@ "sim":56.0, "partner":"6e2f" }, - { - "sim":56.0, - "partner":"6bo9" - }, { "sim":56.0, "partner":"6boa" @@ -314571,6 +315669,10 @@ "sim":56.0, "partner":"6bo8" }, + { + "sim":56.0, + "partner":"6bo9" + }, { "sim":54.0, "partner":"6dcx" @@ -314619,6 +315721,10 @@ "sim":52.0, "partner":"5is0" }, + { + "sim":52.0, + "partner":"8ycp" + }, { "sim":51.0, "partner":"3deo" @@ -314711,9 +315817,9 @@ "subtitle":"Kemp eliminase hg3.17 mutant q50f, e47n, n300d complexed with transition state analog 6-nitrobenzotriazole", "tags":[ "de novo protein", - "enzyme", "protein design", - "kemp eliminase" + "kemp eliminase", + "enzyme" ], "keywords":[ "description", @@ -314750,11 +315856,11 @@ "seq_thr_sim_designed":[ { "sim":655.0, - "partner":"6sry" + "partner":"6srz" }, { "sim":655.0, - "partner":"6srz" + "partner":"6sry" }, { "sim":654.0, @@ -314762,11 +315868,11 @@ }, { "sim":652.0, - "partner":"6ss1" + "partner":"6tu6" }, { "sim":652.0, - "partner":"6tu6" + "partner":"6ss1" } ], "seq_thr_sim_natural":[ @@ -314784,11 +315890,11 @@ }, { "sim":560.0, - "partner":"1gok" + "partner":"1k6a" }, { "sim":560.0, - "partner":"1k6a" + "partner":"1gok" }, { "sim":560.0, @@ -314892,27 +315998,27 @@ }, { "sim":236.0, - "partner":"1isv" + "partner":"5gqd" }, { "sim":236.0, - "partner":"1isw" + "partner":"1isv" }, { "sim":236.0, - "partner":"5gqd" + "partner":"1xyf" }, { "sim":236.0, - "partner":"1isx" + "partner":"5gqe" }, { "sim":236.0, - "partner":"1xyf" + "partner":"1isw" }, { "sim":236.0, - "partner":"5gqe" + "partner":"1isx" }, { "sim":236.0, @@ -314946,10 +316052,6 @@ "sim":235.0, "partner":"1e0v" }, - { - "sim":235.0, - "partner":"2d23" - }, { "sim":235.0, "partner":"2d24" @@ -314967,12 +316069,8 @@ "partner":"2d22" }, { - "sim":234.0, - "partner":"1v0k" - }, - { - "sim":234.0, - "partner":"3wue" + "sim":235.0, + "partner":"2d23" }, { "sim":234.0, @@ -315002,6 +316100,14 @@ "sim":234.0, "partner":"3wub" }, + { + "sim":234.0, + "partner":"1v0k" + }, + { + "sim":234.0, + "partner":"3wue" + }, { "sim":233.0, "partner":"1xas" @@ -315100,19 +316206,19 @@ }, { "sim":170.0, - "partner":"1vbu" + "partner":"1vbr" }, { "sim":170.0, - "partner":"1vbr" + "partner":"1vbu" }, { "sim":169.0, - "partner":"3nj3" + "partner":"3niy" }, { "sim":169.0, - "partner":"3niy" + "partner":"3nj3" }, { "sim":166.0, @@ -315132,11 +316238,11 @@ }, { "sim":163.0, - "partner":"3w25" + "partner":"3w26" }, { "sim":163.0, - "partner":"3w26" + "partner":"3w25" }, { "sim":154.0, @@ -315160,11 +316266,11 @@ }, { "sim":151.0, - "partner":"5xzu" + "partner":"5xzo" }, { "sim":151.0, - "partner":"5xzo" + "partner":"5xzu" }, { "sim":151.0, @@ -315228,11 +316334,11 @@ }, { "sim":141.0, - "partner":"5d4y" + "partner":"5ay7" }, { "sim":141.0, - "partner":"5ay7" + "partner":"5d4y" }, { "sim":140.0, @@ -315314,10 +316420,6 @@ "sim":125.0, "partner":"2fgl" }, - { - "sim":125.0, - "partner":"5eff" - }, { "sim":125.0, "partner":"4qce" @@ -315334,21 +316436,25 @@ "sim":125.0, "partner":"4qdm" }, + { + "sim":125.0, + "partner":"5eff" + }, { "sim":124.0, "partner":"6d5c" }, { "sim":124.0, - "partner":"5efd" + "partner":"5xc0" }, { "sim":124.0, - "partner":"5xc1" + "partner":"5efd" }, { "sim":124.0, - "partner":"5xc0" + "partner":"5xc1" }, { "sim":123.0, @@ -315408,15 +316514,15 @@ }, { "sim":70.0, - "partner":"2w5f" + "partner":"2wze" }, { "sim":70.0, - "partner":"2wze" + "partner":"2wys" }, { "sim":70.0, - "partner":"2wys" + "partner":"2w5f" }, { "sim":50.0, @@ -315489,7 +316595,7 @@ ], "seq_max_sim_designed":{ "sim":655.0, - "partner":"6sry" + "partner":"6srz" }, "seq_max_sim_natural":{ "sim":654.0, @@ -315552,9 +316658,9 @@ "subtitle":"Kemp eliminase hg3.17 mutant q50s, e47n, n300d complexed with transition state analog 6-nitrobenzotriazole", "tags":[ "de novo protein", - "enzyme", "protein design", - "kemp eliminase" + "kemp eliminase", + "enzyme" ], "keywords":[ "description", @@ -315591,11 +316697,11 @@ "seq_thr_sim_designed":[ { "sim":655.0, - "partner":"6ss3" + "partner":"6srz" }, { "sim":655.0, - "partner":"6srz" + "partner":"6ss3" }, { "sim":654.0, @@ -315625,11 +316731,11 @@ }, { "sim":561.0, - "partner":"1gok" + "partner":"1k6a" }, { "sim":561.0, - "partner":"1k6a" + "partner":"1gok" }, { "sim":561.0, @@ -315733,27 +316839,27 @@ }, { "sim":237.0, - "partner":"1isv" + "partner":"5gqd" }, { "sim":237.0, - "partner":"1isw" + "partner":"1isv" }, { "sim":237.0, - "partner":"5gqd" + "partner":"1xyf" }, { "sim":237.0, - "partner":"1isx" + "partner":"5gqe" }, { "sim":237.0, - "partner":"1xyf" + "partner":"1isw" }, { "sim":237.0, - "partner":"5gqe" + "partner":"1isx" }, { "sim":237.0, @@ -315787,10 +316893,6 @@ "sim":236.0, "partner":"1e0v" }, - { - "sim":236.0, - "partner":"2d23" - }, { "sim":236.0, "partner":"2d24" @@ -315808,12 +316910,8 @@ "partner":"2d22" }, { - "sim":235.0, - "partner":"1v0k" - }, - { - "sim":235.0, - "partner":"3wue" + "sim":236.0, + "partner":"2d23" }, { "sim":235.0, @@ -315843,6 +316941,14 @@ "sim":235.0, "partner":"3wub" }, + { + "sim":235.0, + "partner":"1v0k" + }, + { + "sim":235.0, + "partner":"3wue" + }, { "sim":234.0, "partner":"1xas" @@ -315941,19 +317047,19 @@ }, { "sim":171.0, - "partner":"1vbu" + "partner":"1vbr" }, { "sim":171.0, - "partner":"1vbr" + "partner":"1vbu" }, { "sim":170.0, - "partner":"3nj3" + "partner":"3niy" }, { "sim":170.0, - "partner":"3niy" + "partner":"3nj3" }, { "sim":167.0, @@ -315973,11 +317079,11 @@ }, { "sim":164.0, - "partner":"3w25" + "partner":"3w26" }, { "sim":164.0, - "partner":"3w26" + "partner":"3w25" }, { "sim":155.0, @@ -316005,11 +317111,11 @@ }, { "sim":152.0, - "partner":"5xzu" + "partner":"5xzo" }, { "sim":152.0, - "partner":"5xzo" + "partner":"5xzu" }, { "sim":152.0, @@ -316049,11 +317155,11 @@ }, { "sim":143.0, - "partner":"5d4y" + "partner":"5ay7" }, { "sim":143.0, - "partner":"5ay7" + "partner":"5d4y" }, { "sim":143.0, @@ -316157,35 +317263,35 @@ }, { "sim":126.0, - "partner":"5efd" + "partner":"4qce" }, { "sim":126.0, - "partner":"5xc1" + "partner":"4qcf" }, { "sim":126.0, - "partner":"5eff" + "partner":"5eb8" }, { "sim":126.0, - "partner":"4qce" + "partner":"4qdm" }, { "sim":126.0, - "partner":"4qcf" + "partner":"5xc0" }, { "sim":126.0, - "partner":"5eb8" + "partner":"5efd" }, { "sim":126.0, - "partner":"4qdm" + "partner":"5xc1" }, { "sim":126.0, - "partner":"5xc0" + "partner":"5eff" }, { "sim":125.0, @@ -316249,15 +317355,15 @@ }, { "sim":72.0, - "partner":"2w5f" + "partner":"2wze" }, { "sim":72.0, - "partner":"2wze" + "partner":"2wys" }, { "sim":72.0, - "partner":"2wys" + "partner":"2w5f" }, { "sim":51.0, @@ -316330,7 +317436,7 @@ ], "seq_max_sim_designed":{ "sim":655.0, - "partner":"6ss3" + "partner":"6srz" }, "seq_max_sim_natural":{ "sim":655.0, @@ -316393,9 +317499,9 @@ "subtitle":"Kemp eliminase hg3.17 mutant q50h, e47n, n300d complexed with transition state analog 6-nitrobenzotriazole", "tags":[ "de novo protein", - "enzyme", "protein design", - "kemp eliminase" + "kemp eliminase", + "enzyme" ], "keywords":[ "description", @@ -316432,11 +317538,11 @@ "seq_thr_sim_designed":[ { "sim":655.0, - "partner":"6ss3" + "partner":"6sry" }, { "sim":655.0, - "partner":"6sry" + "partner":"6ss3" }, { "sim":654.0, @@ -316466,11 +317572,11 @@ }, { "sim":561.0, - "partner":"1gok" + "partner":"1k6a" }, { "sim":561.0, - "partner":"1k6a" + "partner":"1gok" }, { "sim":561.0, @@ -316574,27 +317680,27 @@ }, { "sim":237.0, - "partner":"1isv" + "partner":"5gqd" }, { "sim":237.0, - "partner":"1isw" + "partner":"1isv" }, { "sim":237.0, - "partner":"5gqd" + "partner":"1xyf" }, { "sim":237.0, - "partner":"1isx" + "partner":"5gqe" }, { "sim":237.0, - "partner":"1xyf" + "partner":"1isw" }, { "sim":237.0, - "partner":"5gqe" + "partner":"1isx" }, { "sim":237.0, @@ -316628,10 +317734,6 @@ "sim":236.0, "partner":"1e0v" }, - { - "sim":236.0, - "partner":"2d23" - }, { "sim":236.0, "partner":"2d24" @@ -316649,12 +317751,8 @@ "partner":"2d22" }, { - "sim":235.0, - "partner":"1v0k" - }, - { - "sim":235.0, - "partner":"3wue" + "sim":236.0, + "partner":"2d23" }, { "sim":235.0, @@ -316684,6 +317782,14 @@ "sim":235.0, "partner":"3wub" }, + { + "sim":235.0, + "partner":"1v0k" + }, + { + "sim":235.0, + "partner":"3wue" + }, { "sim":234.0, "partner":"1xas" @@ -316780,25 +317886,21 @@ "sim":174.0, "partner":"4xx6" }, - { - "sim":171.0, - "partner":"1vbu" - }, { "sim":171.0, "partner":"1vbr" }, { - "sim":169.0, - "partner":"3nj3" + "sim":171.0, + "partner":"1vbu" }, { "sim":169.0, "partner":"3niy" }, { - "sim":166.0, - "partner":"3w24" + "sim":169.0, + "partner":"3nj3" }, { "sim":166.0, @@ -316813,13 +317915,17 @@ "partner":"3w29" }, { - "sim":164.0, - "partner":"3w25" + "sim":166.0, + "partner":"3w24" }, { "sim":164.0, "partner":"3w26" }, + { + "sim":164.0, + "partner":"3w25" + }, { "sim":154.0, "partner":"1xys" @@ -316850,11 +317956,11 @@ }, { "sim":151.0, - "partner":"5xzu" + "partner":"5xzo" }, { "sim":151.0, - "partner":"5xzo" + "partner":"5xzu" }, { "sim":151.0, @@ -316910,11 +318016,11 @@ }, { "sim":142.0, - "partner":"5d4y" + "partner":"5ay7" }, { "sim":142.0, - "partner":"5ay7" + "partner":"5d4y" }, { "sim":141.0, @@ -316996,10 +318102,6 @@ "sim":126.0, "partner":"2fgl" }, - { - "sim":126.0, - "partner":"5eff" - }, { "sim":126.0, "partner":"4qce" @@ -317016,17 +318118,21 @@ "sim":126.0, "partner":"4qdm" }, + { + "sim":126.0, + "partner":"5eff" + }, { "sim":125.0, - "partner":"5efd" + "partner":"5xc0" }, { "sim":125.0, - "partner":"5xc1" + "partner":"5efd" }, { "sim":125.0, - "partner":"5xc0" + "partner":"5xc1" }, { "sim":124.0, @@ -317090,15 +318196,15 @@ }, { "sim":71.0, - "partner":"2w5f" + "partner":"2wze" }, { "sim":71.0, - "partner":"2wze" + "partner":"2wys" }, { "sim":71.0, - "partner":"2wys" + "partner":"2w5f" }, { "sim":51.0, @@ -317171,7 +318277,7 @@ ], "seq_max_sim_designed":{ "sim":655.0, - "partner":"6ss3" + "partner":"6sry" }, "seq_max_sim_natural":{ "sim":655.0, @@ -317234,9 +318340,9 @@ "subtitle":"Kemp eliminase hg3.17 mutant q50a, e47n, n300d complexed with transition state analog 6-nitrobenzotriazole", "tags":[ "de novo protein", - "enzyme", "protein design", - "kemp eliminase" + "kemp eliminase", + "enzyme" ], "keywords":[ "description", @@ -317273,11 +318379,11 @@ "seq_thr_sim_designed":[ { "sim":653.0, - "partner":"6ss3" + "partner":"6sry" }, { "sim":653.0, - "partner":"6sry" + "partner":"6ss3" }, { "sim":652.0, @@ -317307,11 +318413,11 @@ }, { "sim":561.0, - "partner":"1gok" + "partner":"1k6a" }, { "sim":561.0, - "partner":"1k6a" + "partner":"1gok" }, { "sim":561.0, @@ -317415,27 +318521,27 @@ }, { "sim":237.0, - "partner":"1isv" + "partner":"5gqd" }, { "sim":237.0, - "partner":"1isw" + "partner":"1isv" }, { "sim":237.0, - "partner":"5gqd" + "partner":"1xyf" }, { "sim":237.0, - "partner":"1isx" + "partner":"5gqe" }, { "sim":237.0, - "partner":"1xyf" + "partner":"1isw" }, { "sim":237.0, - "partner":"5gqe" + "partner":"1isx" }, { "sim":237.0, @@ -317469,10 +318575,6 @@ "sim":236.0, "partner":"1e0v" }, - { - "sim":236.0, - "partner":"2d23" - }, { "sim":236.0, "partner":"2d24" @@ -317490,12 +318592,8 @@ "partner":"2d22" }, { - "sim":235.0, - "partner":"1v0k" - }, - { - "sim":235.0, - "partner":"3wue" + "sim":236.0, + "partner":"2d23" }, { "sim":235.0, @@ -317525,6 +318623,14 @@ "sim":235.0, "partner":"3wub" }, + { + "sim":235.0, + "partner":"1v0k" + }, + { + "sim":235.0, + "partner":"3wue" + }, { "sim":234.0, "partner":"1xas" @@ -317621,25 +318727,21 @@ "sim":174.0, "partner":"4xx6" }, - { - "sim":171.0, - "partner":"1vbu" - }, { "sim":171.0, "partner":"1vbr" }, { - "sim":169.0, - "partner":"3nj3" + "sim":171.0, + "partner":"1vbu" }, { "sim":169.0, "partner":"3niy" }, { - "sim":166.0, - "partner":"3w24" + "sim":169.0, + "partner":"3nj3" }, { "sim":166.0, @@ -317654,13 +318756,17 @@ "partner":"3w29" }, { - "sim":164.0, - "partner":"3w25" + "sim":166.0, + "partner":"3w24" }, { "sim":164.0, "partner":"3w26" }, + { + "sim":164.0, + "partner":"3w25" + }, { "sim":154.0, "partner":"1xys" @@ -317691,11 +318797,11 @@ }, { "sim":151.0, - "partner":"5xzu" + "partner":"5xzo" }, { "sim":151.0, - "partner":"5xzo" + "partner":"5xzu" }, { "sim":148.0, @@ -317751,11 +318857,11 @@ }, { "sim":142.0, - "partner":"5d4y" + "partner":"5ay7" }, { "sim":142.0, - "partner":"5ay7" + "partner":"5d4y" }, { "sim":141.0, @@ -317833,10 +318939,6 @@ "sim":126.0, "partner":"2fgl" }, - { - "sim":126.0, - "partner":"5eff" - }, { "sim":126.0, "partner":"4qce" @@ -317853,21 +318955,25 @@ "sim":126.0, "partner":"4qdm" }, + { + "sim":126.0, + "partner":"5eff" + }, { "sim":125.0, "partner":"4l4p" }, { "sim":125.0, - "partner":"5efd" + "partner":"5xc0" }, { "sim":125.0, - "partner":"5xc1" + "partner":"5efd" }, { "sim":125.0, - "partner":"5xc0" + "partner":"5xc1" }, { "sim":124.0, @@ -317931,15 +319037,15 @@ }, { "sim":71.0, - "partner":"2w5f" + "partner":"2wze" }, { "sim":71.0, - "partner":"2wze" + "partner":"2wys" }, { "sim":71.0, - "partner":"2wys" + "partner":"2w5f" }, { "sim":51.0, @@ -318008,7 +319114,7 @@ ], "seq_max_sim_designed":{ "sim":653.0, - "partner":"6ss3" + "partner":"6sry" }, "seq_max_sim_natural":{ "sim":652.0, @@ -318071,9 +319177,9 @@ "subtitle":"Kemp eliminase hg3.17 mutant q50k, e47n, n300d complexed with transition state analog 6-nitrobenzotriazole", "tags":[ "de novo protein", - "enzyme", "protein design", - "kemp eliminase" + "kemp eliminase", + "enzyme" ], "keywords":[ "description", @@ -318110,11 +319216,11 @@ "seq_thr_sim_designed":[ { "sim":655.0, - "partner":"6sry" + "partner":"6srz" }, { "sim":655.0, - "partner":"6srz" + "partner":"6sry" }, { "sim":653.0, @@ -318144,11 +319250,11 @@ }, { "sim":563.0, - "partner":"1gok" + "partner":"1k6a" }, { "sim":563.0, - "partner":"1k6a" + "partner":"1gok" }, { "sim":563.0, @@ -318252,27 +319358,27 @@ }, { "sim":239.0, - "partner":"1isv" + "partner":"5gqd" }, { "sim":239.0, - "partner":"1isw" + "partner":"1isv" }, { "sim":239.0, - "partner":"5gqd" + "partner":"1xyf" }, { "sim":239.0, - "partner":"1isx" + "partner":"5gqe" }, { "sim":239.0, - "partner":"1xyf" + "partner":"1isw" }, { "sim":239.0, - "partner":"5gqe" + "partner":"1isx" }, { "sim":239.0, @@ -318306,10 +319412,6 @@ "sim":238.0, "partner":"1e0v" }, - { - "sim":238.0, - "partner":"2d23" - }, { "sim":238.0, "partner":"2d24" @@ -318327,12 +319429,8 @@ "partner":"2d22" }, { - "sim":237.0, - "partner":"1v0k" - }, - { - "sim":237.0, - "partner":"3wue" + "sim":238.0, + "partner":"2d23" }, { "sim":237.0, @@ -318362,6 +319460,14 @@ "sim":237.0, "partner":"3wub" }, + { + "sim":237.0, + "partner":"1v0k" + }, + { + "sim":237.0, + "partner":"3wue" + }, { "sim":236.0, "partner":"1xas" @@ -318460,19 +319566,19 @@ }, { "sim":173.0, - "partner":"1vbu" + "partner":"1vbr" }, { "sim":173.0, - "partner":"1vbr" + "partner":"1vbu" }, { "sim":172.0, - "partner":"3nj3" + "partner":"3niy" }, { "sim":172.0, - "partner":"3niy" + "partner":"3nj3" }, { "sim":169.0, @@ -318492,11 +319598,11 @@ }, { "sim":166.0, - "partner":"3w25" + "partner":"3w26" }, { "sim":166.0, - "partner":"3w26" + "partner":"3w25" }, { "sim":157.0, @@ -318520,11 +319626,11 @@ }, { "sim":154.0, - "partner":"5xzu" + "partner":"5xzo" }, { "sim":154.0, - "partner":"5xzo" + "partner":"5xzu" }, { "sim":154.0, @@ -318568,11 +319674,11 @@ }, { "sim":145.0, - "partner":"5d4y" + "partner":"5ay7" }, { "sim":145.0, - "partner":"5ay7" + "partner":"5d4y" }, { "sim":145.0, @@ -318676,35 +319782,35 @@ }, { "sim":128.0, - "partner":"5efd" + "partner":"4qce" }, { "sim":128.0, - "partner":"5xc1" + "partner":"4qcf" }, { "sim":128.0, - "partner":"5eff" + "partner":"5eb8" }, { "sim":128.0, - "partner":"4qce" + "partner":"4qdm" }, { "sim":128.0, - "partner":"4qcf" + "partner":"5xc0" }, { "sim":128.0, - "partner":"5eb8" + "partner":"5efd" }, { "sim":128.0, - "partner":"4qdm" + "partner":"5xc1" }, { "sim":128.0, - "partner":"5xc0" + "partner":"5eff" }, { "sim":127.0, @@ -318768,15 +319874,15 @@ }, { "sim":74.0, - "partner":"2w5f" + "partner":"2wze" }, { "sim":74.0, - "partner":"2wze" + "partner":"2wys" }, { "sim":74.0, - "partner":"2wys" + "partner":"2w5f" }, { "sim":53.0, @@ -318849,7 +319955,7 @@ ], "seq_max_sim_designed":{ "sim":655.0, - "partner":"6sry" + "partner":"6srz" }, "seq_max_sim_natural":{ "sim":655.0, @@ -319000,116 +320106,116 @@ ], "subtitle":"Crystal structure of a de novo designed hexameric helical-bundle protein", "tags":[ - "computational protein design", + "helical bundle", + "biosynthetic protein", "pore", "de novo protein", - "hexamer", - "helical bundle", - "biosynthetic protein" + "computational protein design", + "hexamer" ], "keywords":[ - "concentric", - "opens", - "fluorophores", - "matches", - "channels", - "ions", - "challenge", - "door", - "expressed", - "roles", - "crystal", - "alexa", - "fluor", + "biotechnological", + "biotinylated", + "488", + "key", "show", - "synthetic", - "pores", - "passage", - "structure", - "structurally", - "sequencing", - "however", - "modification", - "proteins", - "membrane", - "models", - "dna", - "enables", - "de", "outstanding", - "produce", - "amphiphilic", - "rings", + "functionally", "pore", - "processes", - "resulting", - "remains", - "liposomes", + "roles", + "model", + "protein", + "insect", "vitro", - "occurring", - "ability", + "across", + "microscopy", + "novo", + "cells", "match", + "forms", + "amphiphilic", + "two", + "variety", + "applications", + "recent", + "crystal", + "stable", + "door", + "using", + "occurring", + "monodisperse", "enough", - "structures", - "naturally", - "biotechnological", - "potassium", - "biotinylated", - "transmembrane", - "form", - "functionally", - "designer", - "considerable", - "entrance", + "enables", + "however", + "formed", + "interest", + "creation", + "dna", + "biological", + "specific", "incorporated", + "matches", + "entrance", + "conducting", + "proteins", "large", - "chemical", - "report", + "capable", + "ions", "blocked", + "alexa", + "found", + "chemical", + "electrophysiology", + "computational", "1", - "redesigning", - "interest", - "conducting", - "closely", - "synthesis", - "specific", + "concentric", "advances", - "488", - "insect", "design", - "model", - "using", - "applications", - "nanopore", - "selectively", - "across", - "recent", - "high", - "biological", - "key", - "cells", "sodium", - "ion", - "fundamental", - "monodisperse", - "novo", - "stable", - "wide", + "produce", + "processes", + "nanopore", + "synthesis", "experiments", + "selectivity", + "wide", + "liposomes", + "ability", + "sequencing", + "fluor", + "designer", + "selectively", + "channels", "peptides", + "potassium", + "pores", + "fundamental", + "form", + "fluorophores", + "models", + "naturally", + "modification", + "transmembrane", + "opens", + "structurally", + "structures", + "de", + "expressed", + "remains", + "structure", + "synthetic", + "report", + "resulting", + "closely", + "ion", + "membrane", + "redesigning", "enable", - "capable", - "found", - "selectivity", - "two", - "creation", - "protein", - "microscopy", - "electrophysiology", - "variety", - "computational", - "formed", - "forms" + "passage", + "considerable", + "high", + "rings", + "challenge" ], "release_date":"2020-04-29", "publication":"\"Computational design of transmembrane pores\", Nature, 585, 129-134", @@ -319198,19 +320304,19 @@ }, { "sim":51.0, - "partner":"5dns" + "partner":"5dn0" }, { "sim":51.0, - "partner":"5dn0" + "partner":"5dns" }, { "sim":51.0, - "partner":"5dzb" + "partner":"4yfo" }, { "sim":51.0, - "partner":"4yfo" + "partner":"5dzb" }, { "sim":50.0, @@ -319228,15 +320334,15 @@ "seq_thr_sim_natural":[ { "sim":62.0, - "partner":"5lj7" + "partner":"5lil" }, { "sim":62.0, - "partner":"5lil" + "partner":"5lj6" }, { "sim":62.0, - "partner":"5lj6" + "partner":"5lj7" }, { "sim":60.0, @@ -319254,10 +320360,6 @@ "sim":59.0, "partner":"3et3" }, - { - "sim":59.0, - "partner":"3aio" - }, { "sim":59.0, "partner":"3aik" @@ -319274,6 +320376,10 @@ "sim":59.0, "partner":"3ain" }, + { + "sim":59.0, + "partner":"3aio" + }, { "sim":59.0, "partner":"4wwv" @@ -319324,15 +320430,15 @@ }, { "sim":57.0, - "partner":"2o0h" + "partner":"2o0j" }, { "sim":57.0, - "partner":"2o0j" + "partner":"2o0k" }, { "sim":57.0, - "partner":"2o0k" + "partner":"2o0h" }, { "sim":57.0, @@ -319416,87 +320522,87 @@ }, { "sim":56.0, - "partner":"1xoq" + "partner":"1y2b" }, { "sim":56.0, - "partner":"6ind" + "partner":"6imt" }, { "sim":56.0, - "partner":"1xor" + "partner":"1y2c" }, { "sim":56.0, - "partner":"3iak" + "partner":"6ink" }, { "sim":56.0, - "partner":"6imr" + "partner":"1y2d" }, { "sim":56.0, - "partner":"1y2b" + "partner":"1y2e" }, { "sim":56.0, - "partner":"6im6" + "partner":"6inm" }, { "sim":56.0, - "partner":"6imt" + "partner":"6imb" }, { "sim":56.0, - "partner":"1y2c" + "partner":"6imd" }, { "sim":56.0, - "partner":"1y2d" + "partner":"1y2k" }, { "sim":56.0, - "partner":"6ink" + "partner":"6imi" }, { "sim":56.0, - "partner":"1y2e" + "partner":"6imo" }, { "sim":56.0, - "partner":"6inm" + "partner":"1xom" }, { "sim":56.0, - "partner":"6imb" + "partner":"1xon" }, { "sim":56.0, - "partner":"6imd" + "partner":"3k4s" }, { "sim":56.0, - "partner":"1y2k" + "partner":"6ind" }, { "sim":56.0, - "partner":"1xom" + "partner":"1xoq" }, { "sim":56.0, - "partner":"6imi" + "partner":"6imr" }, { "sim":56.0, - "partner":"6imo" + "partner":"1xor" }, { "sim":56.0, - "partner":"1xon" + "partner":"6im6" }, { "sim":56.0, - "partner":"3k4s" + "partner":"3iak" }, { "sim":56.0, @@ -319574,14 +320680,6 @@ "sim":55.0, "partner":"1jyl" }, - { - "sim":55.0, - "partner":"5ds3" - }, - { - "sim":55.0, - "partner":"6bhv" - }, { "sim":55.0, "partner":"6ntu" @@ -319608,12 +320706,20 @@ }, { "sim":55.0, - "partner":"4rni" + "partner":"6bhv" + }, + { + "sim":55.0, + "partner":"5ds3" }, { "sim":55.0, "partner":"4rnj" }, + { + "sim":55.0, + "partner":"4rni" + }, { "sim":55.0, "partner":"5y7x" @@ -319638,10 +320744,6 @@ "sim":55.0, "partner":"6jv1" }, - { - "sim":55.0, - "partner":"3g3d" - }, { "sim":55.0, "partner":"3bvj" @@ -319660,23 +320762,19 @@ }, { "sim":55.0, - "partner":"4dmz" - }, - { - "sim":55.0, - "partner":"4dn0" + "partner":"3g3d" }, { "sim":55.0, - "partner":"4j51" + "partner":"4dmz" }, { "sim":55.0, - "partner":"2nq6" + "partner":"4dn0" }, { "sim":55.0, - "partner":"2nq7" + "partner":"4j51" }, { "sim":55.0, @@ -319710,6 +320808,14 @@ "sim":55.0, "partner":"2gz5" }, + { + "sim":55.0, + "partner":"2nq6" + }, + { + "sim":55.0, + "partner":"2nq7" + }, { "sim":55.0, "partner":"4y4v" @@ -319726,10 +320832,6 @@ "sim":55.0, "partner":"3obw" }, - { - "sim":55.0, - "partner":"5hxu" - }, { "sim":55.0, "partner":"5hy1" @@ -319744,12 +320846,16 @@ }, { "sim":55.0, - "partner":"6e9b" + "partner":"5hxu" }, { "sim":55.0, "partner":"6e57" }, + { + "sim":55.0, + "partner":"6e9b" + }, { "sim":55.0, "partner":"6hr7" @@ -319764,15 +320870,15 @@ }, { "sim":55.0, - "partner":"4l2h" + "partner":"4epp" }, { "sim":55.0, - "partner":"4epp" + "partner":"4epq" }, { "sim":55.0, - "partner":"4epq" + "partner":"4l2h" }, { "sim":55.0, @@ -319800,15 +320906,15 @@ }, { "sim":55.0, - "partner":"6tsh" + "partner":"6tsk" }, { "sim":55.0, - "partner":"6tte" + "partner":"6tsh" }, { "sim":55.0, - "partner":"6tsk" + "partner":"6tte" }, { "sim":54.0, @@ -319828,23 +320934,23 @@ }, { "sim":54.0, - "partner":"1zw3" + "partner":"1zvz" }, { "sim":54.0, - "partner":"6hxo" + "partner":"6hxn" }, { "sim":54.0, - "partner":"1zvz" + "partner":"6hxo" }, { "sim":54.0, - "partner":"6hxn" + "partner":"1zw2" }, { "sim":54.0, - "partner":"1zw2" + "partner":"1zw3" }, { "sim":54.0, @@ -319864,11 +320970,11 @@ }, { "sim":54.0, - "partner":"3wcf" + "partner":"3wc9" }, { "sim":54.0, - "partner":"3wc9" + "partner":"3wcf" }, { "sim":54.0, @@ -320036,15 +321142,15 @@ }, { "sim":53.0, - "partner":"1vb6" + "partner":"1v9y" }, { "sim":53.0, - "partner":"1v9y" + "partner":"1v9z" }, { "sim":53.0, - "partner":"1v9z" + "partner":"1vb6" }, { "sim":53.0, @@ -320062,10 +321168,6 @@ "sim":53.0, "partner":"5w10" }, - { - "sim":53.0, - "partner":"5wg9" - }, { "sim":53.0, "partner":"5wap" @@ -320166,6 +321268,10 @@ "sim":53.0, "partner":"5wei" }, + { + "sim":53.0, + "partner":"5wg9" + }, { "sim":53.0, "partner":"4mh3" @@ -320208,11 +321314,11 @@ }, { "sim":53.0, - "partner":"5cvd" + "partner":"5cve" }, { "sim":53.0, - "partner":"5cve" + "partner":"5cvd" }, { "sim":53.0, @@ -320282,17 +321388,13 @@ "sim":53.0, "partner":"5e0n" }, - { - "sim":53.0, - "partner":"6iqs" - }, { "sim":53.0, "partner":"6iqq" }, { "sim":53.0, - "partner":"4pgc" + "partner":"6iqs" }, { "sim":53.0, @@ -320312,19 +321414,23 @@ }, { "sim":53.0, - "partner":"3nha" + "partner":"4pgc" }, { "sim":53.0, - "partner":"3nhb" + "partner":"3nh6" }, { "sim":53.0, - "partner":"3nh6" + "partner":"3nh9" }, { "sim":53.0, - "partner":"3nh9" + "partner":"3nha" + }, + { + "sim":53.0, + "partner":"3nhb" }, { "sim":53.0, @@ -320366,17 +321472,13 @@ "sim":53.0, "partner":"5m8b" }, - { - "sim":53.0, - "partner":"1t9s" - }, { "sim":53.0, "partner":"1tbf" }, { "sim":53.0, - "partner":"4d2w" + "partner":"1t9s" }, { "sim":53.0, @@ -320410,6 +321512,10 @@ "sim":53.0, "partner":"4d2v" }, + { + "sim":53.0, + "partner":"4d2w" + }, { "sim":53.0, "partner":"1xoz" @@ -320432,11 +321538,11 @@ }, { "sim":53.0, - "partner":"4gpu" + "partner":"4gps" }, { "sim":53.0, - "partner":"4gps" + "partner":"4gpu" }, { "sim":53.0, @@ -320458,10 +321564,6 @@ "sim":53.0, "partner":"3v6a" }, - { - "sim":53.0, - "partner":"4cdm" - }, { "sim":53.0, "partner":"4cdn" @@ -320478,6 +321580,10 @@ "sim":53.0, "partner":"5zcw" }, + { + "sim":53.0, + "partner":"4cdm" + }, { "sim":53.0, "partner":"1rff" @@ -320710,10 +321816,6 @@ "sim":52.0, "partner":"4nec" }, - { - "sim":52.0, - "partner":"4jyi" - }, { "sim":52.0, "partner":"4dm6" @@ -320750,6 +321852,10 @@ "sim":52.0, "partner":"4jyh" }, + { + "sim":52.0, + "partner":"4jyi" + }, { "sim":52.0, "partner":"2zvw" @@ -320772,31 +321878,31 @@ }, { "sim":52.0, - "partner":"3quo" + "partner":"3qur" }, { "sim":52.0, - "partner":"3qvf" + "partner":"3qvh" }, { "sim":52.0, - "partner":"3qur" + "partner":"3d40" }, { "sim":52.0, - "partner":"3qvh" + "partner":"3d41" }, { "sim":52.0, - "partner":"3d40" + "partner":"3qun" }, { "sim":52.0, - "partner":"3d41" + "partner":"3quo" }, { "sim":52.0, - "partner":"3qun" + "partner":"3qvf" }, { "sim":52.0, @@ -320814,10 +321920,6 @@ "sim":52.0, "partner":"5ita" }, - { - "sim":52.0, - "partner":"4rtl" - }, { "sim":52.0, "partner":"4rtm" @@ -320860,7 +321962,7 @@ }, { "sim":52.0, - "partner":"3ta4" + "partner":"4rtl" }, { "sim":52.0, @@ -320868,16 +321970,20 @@ }, { "sim":52.0, - "partner":"4rw3" + "partner":"3ta4" }, { "sim":52.0, - "partner":"5lsg" + "partner":"4rw3" }, { "sim":52.0, "partner":"6t9c" }, + { + "sim":52.0, + "partner":"5lsg" + }, { "sim":52.0, "partner":"6qj5" @@ -320942,14 +322048,6 @@ "sim":52.0, "partner":"2b4u" }, - { - "sim":52.0, - "partner":"5tyq" - }, - { - "sim":52.0, - "partner":"5u19" - }, { "sim":52.0, "partner":"5u0n" @@ -320968,19 +322066,15 @@ }, { "sim":52.0, - "partner":"5m8e" - }, - { - "sim":52.0, - "partner":"3sie" + "partner":"5tyq" }, { "sim":52.0, - "partner":"4g2w" + "partner":"5u19" }, { "sim":52.0, - "partner":"4g2y" + "partner":"5m8e" }, { "sim":52.0, @@ -321010,6 +322104,18 @@ "sim":52.0, "partner":"3shz" }, + { + "sim":52.0, + "partner":"3sie" + }, + { + "sim":52.0, + "partner":"4g2w" + }, + { + "sim":52.0, + "partner":"4g2y" + }, { "sim":52.0, "partner":"3ren" @@ -321084,15 +322190,15 @@ }, { "sim":52.0, - "partner":"4hcl" + "partner":"4hcd" }, { "sim":52.0, - "partner":"4hcd" + "partner":"4hch" }, { "sim":52.0, - "partner":"4hch" + "partner":"4hcl" }, { "sim":52.0, @@ -321100,47 +322206,47 @@ }, { "sim":52.0, - "partner":"2y46" + "partner":"3zsn" }, { "sim":52.0, - "partner":"2y5n" + "partner":"2y98" }, { "sim":52.0, - "partner":"2yca" + "partner":"2y5z" }, { "sim":52.0, - "partner":"3zsn" + "partner":"4aw3" }, { "sim":52.0, - "partner":"2y98" + "partner":"2ygx" }, { "sim":52.0, - "partner":"2y5z" + "partner":"2y46" }, { "sim":52.0, - "partner":"4aw3" + "partner":"2y5n" }, { "sim":52.0, - "partner":"2ygx" + "partner":"2yca" }, { "sim":52.0, - "partner":"4zyj" + "partner":"8s53" }, { "sim":52.0, - "partner":"4zxv" + "partner":"4zyj" }, { "sim":52.0, - "partner":"5z8a" + "partner":"4zxv" }, { "sim":52.0, @@ -321150,6 +322256,10 @@ "sim":52.0, "partner":"5z83" }, + { + "sim":52.0, + "partner":"5z8a" + }, { "sim":52.0, "partner":"2o1t" @@ -321220,35 +322330,35 @@ }, { "sim":52.0, - "partner":"3ahc" + "partner":"3ahf" }, { "sim":52.0, - "partner":"3ahd" + "partner":"3ahg" }, { "sim":52.0, - "partner":"3ahe" + "partner":"3ahh" }, { "sim":52.0, - "partner":"3ahf" + "partner":"3ahi" }, { "sim":52.0, - "partner":"3ahg" + "partner":"3ahj" }, { "sim":52.0, - "partner":"3ahh" + "partner":"3ahc" }, { "sim":52.0, - "partner":"3ahi" + "partner":"3ahd" }, { "sim":52.0, - "partner":"3ahj" + "partner":"3ahe" }, { "sim":52.0, @@ -321404,15 +322514,15 @@ }, { "sim":51.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":51.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":51.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":51.0, @@ -321434,10 +322544,6 @@ "sim":51.0, "partner":"2bze" }, - { - "sim":51.0, - "partner":"3rg6" - }, { "sim":51.0, "partner":"2wvw" @@ -321454,6 +322560,10 @@ "sim":51.0, "partner":"6lag" }, + { + "sim":51.0, + "partner":"3rg6" + }, { "sim":51.0, "partner":"4zwt" @@ -321476,31 +322586,27 @@ }, { "sim":51.0, - "partner":"4evc" - }, - { - "sim":51.0, - "partner":"4evd" + "partner":"3ta8" }, { "sim":51.0, - "partner":"4eve" + "partner":"3t9j" }, { "sim":51.0, - "partner":"3ta8" + "partner":"4evb" }, { "sim":51.0, - "partner":"3t9j" + "partner":"4evc" }, { "sim":51.0, - "partner":"4evb" + "partner":"4evd" }, { "sim":51.0, - "partner":"2vbq" + "partner":"4eve" }, { "sim":51.0, @@ -321514,6 +322620,10 @@ "sim":51.0, "partner":"1s60" }, + { + "sim":51.0, + "partner":"2vbq" + }, { "sim":51.0, "partner":"2mux" @@ -321658,10 +322768,6 @@ "sim":51.0, "partner":"2vh2" }, - { - "sim":51.0, - "partner":"6ey1" - }, { "sim":51.0, "partner":"3du1" @@ -321672,15 +322778,15 @@ }, { "sim":51.0, - "partner":"2yfa" + "partner":"6ey1" }, { "sim":51.0, - "partner":"2yfb" + "partner":"2yfa" }, { "sim":51.0, - "partner":"4be6" + "partner":"2yfb" }, { "sim":51.0, @@ -321694,6 +322800,10 @@ "sim":51.0, "partner":"4be5" }, + { + "sim":51.0, + "partner":"4be6" + }, { "sim":51.0, "partner":"4qts" @@ -321728,11 +322838,11 @@ }, { "sim":51.0, - "partner":"4fq7" + "partner":"4fq5" }, { "sim":51.0, - "partner":"4fq5" + "partner":"4fq7" }, { "sim":51.0, @@ -321776,11 +322886,11 @@ }, { "sim":51.0, - "partner":"5y2o" + "partner":"5y2t" }, { "sim":51.0, - "partner":"5y2t" + "partner":"5y2o" }, { "sim":51.0, @@ -321840,11 +322950,11 @@ }, { "sim":51.0, - "partner":"3iok" + "partner":"6mhp" }, { "sim":51.0, - "partner":"6mhp" + "partner":"3iok" }, { "sim":51.0, @@ -321854,10 +322964,6 @@ "sim":51.0, "partner":"5zmy" }, - { - "sim":51.0, - "partner":"3ha3" - }, { "sim":51.0, "partner":"3ha5" @@ -321874,6 +322980,10 @@ "sim":51.0, "partner":"3ha7" }, + { + "sim":51.0, + "partner":"3ha3" + }, { "sim":51.0, "partner":"5cf4" @@ -321904,19 +323014,19 @@ }, { "sim":51.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":51.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":51.0, - "partner":"3tm8" + "partner":"3tmc" }, { "sim":51.0, - "partner":"3tmb" + "partner":"3tmd" }, { "sim":51.0, @@ -321934,10 +323044,6 @@ "sim":51.0, "partner":"2jgv" }, - { - "sim":51.0, - "partner":"3auz" - }, { "sim":51.0, "partner":"2obj" @@ -321954,6 +323060,10 @@ "sim":51.0, "partner":"3bgq" }, + { + "sim":51.0, + "partner":"3auz" + }, { "sim":51.0, "partner":"6q50" @@ -321974,14 +323084,6 @@ "sim":51.0, "partner":"6hm2" }, - { - "sim":51.0, - "partner":"5gg5" - }, - { - "sim":51.0, - "partner":"5xd1" - }, { "sim":51.0, "partner":"5gg6" @@ -322030,6 +323132,14 @@ "sim":51.0, "partner":"5ggd" }, + { + "sim":51.0, + "partner":"5gg5" + }, + { + "sim":51.0, + "partner":"5xd1" + }, { "sim":51.0, "partner":"5b3f" @@ -322052,27 +323162,27 @@ }, { "sim":51.0, - "partner":"4mfj" + "partner":"4mfl" }, { "sim":51.0, - "partner":"4mfk" + "partner":"4mfp" }, { "sim":51.0, - "partner":"4mfl" + "partner":"4mfq" }, { "sim":51.0, - "partner":"6iix" + "partner":"4mfj" }, { "sim":51.0, - "partner":"4mfp" + "partner":"6iix" }, { "sim":51.0, - "partner":"4mfq" + "partner":"4mfk" }, { "sim":51.0, @@ -322112,7 +323222,7 @@ }, { "sim":51.0, - "partner":"6pi5" + "partner":"6pi6" }, { "sim":51.0, @@ -322120,11 +323230,11 @@ }, { "sim":51.0, - "partner":"6pi6" + "partner":"3esw" }, { "sim":51.0, - "partner":"3esw" + "partner":"6pi5" }, { "sim":51.0, @@ -322134,10 +323244,6 @@ "sim":51.0, "partner":"3txx" }, - { - "sim":51.0, - "partner":"4m1i" - }, { "sim":51.0, "partner":"4d8f" @@ -322152,27 +323258,15 @@ }, { "sim":51.0, - "partner":"1si7" - }, - { - "sim":51.0, - "partner":"5ve3" - }, - { - "sim":51.0, - "partner":"5zzx" - }, - { - "sim":51.0, - "partner":"6a0d" + "partner":"4m1i" }, { "sim":51.0, - "partner":"5zzy" + "partner":"1si7" }, { "sim":51.0, - "partner":"6a0v" + "partner":"5ve3" }, { "sim":51.0, @@ -322324,31 +323418,39 @@ }, { "sim":51.0, - "partner":"3tg1" + "partner":"5zzx" }, { "sim":51.0, - "partner":"3py3" + "partner":"6a0d" }, { "sim":51.0, - "partner":"6put" + "partner":"5zzy" }, { "sim":51.0, - "partner":"6puw" + "partner":"6a0v" }, { "sim":51.0, - "partner":"6puy" + "partner":"3tg1" }, { "sim":51.0, - "partner":"6v3k" + "partner":"3py3" }, { "sim":51.0, - "partner":"5u1c" + "partner":"6puw" + }, + { + "sim":51.0, + "partner":"6puy" + }, + { + "sim":51.0, + "partner":"6v3k" }, { "sim":51.0, @@ -322356,11 +323458,11 @@ }, { "sim":51.0, - "partner":"4q3r" + "partner":"5u1c" }, { "sim":51.0, - "partner":"4q42" + "partner":"6put" }, { "sim":51.0, @@ -322394,6 +323496,14 @@ "sim":51.0, "partner":"4q41" }, + { + "sim":51.0, + "partner":"4q3r" + }, + { + "sim":51.0, + "partner":"4q42" + }, { "sim":51.0, "partner":"3av0" @@ -322486,10 +323596,6 @@ "sim":51.0, "partner":"4w61" }, - { - "sim":51.0, - "partner":"2gqn" - }, { "sim":51.0, "partner":"2fq6" @@ -322504,7 +323610,7 @@ }, { "sim":51.0, - "partner":"4lre" + "partner":"2gqn" }, { "sim":51.0, @@ -322538,6 +323644,10 @@ "sim":51.0, "partner":"4lrd" }, + { + "sim":51.0, + "partner":"4lre" + }, { "sim":51.0, "partner":"3ssm" @@ -322574,10 +323684,6 @@ "sim":51.0, "partner":"4doy" }, - { - "sim":51.0, - "partner":"4q6q" - }, { "sim":51.0, "partner":"4q6m" @@ -322594,6 +323700,10 @@ "sim":51.0, "partner":"4q6p" }, + { + "sim":51.0, + "partner":"4q6q" + }, { "sim":51.0, "partner":"5xwb" @@ -322628,15 +323738,15 @@ }, { "sim":51.0, - "partner":"5v1s" + "partner":"5v1t" }, { "sim":51.0, - "partner":"5v1t" + "partner":"5v1q" }, { "sim":51.0, - "partner":"5v1q" + "partner":"5v1s" }, { "sim":51.0, @@ -322648,11 +323758,11 @@ }, { "sim":51.0, - "partner":"4gt2" + "partner":"4j7c" }, { "sim":51.0, - "partner":"4j7c" + "partner":"4gt2" }, { "sim":51.0, @@ -322666,14 +323776,6 @@ "sim":51.0, "partner":"6qps" }, - { - "sim":51.0, - "partner":"6mlh" - }, - { - "sim":51.0, - "partner":"6mlw" - }, { "sim":51.0, "partner":"6nn1" @@ -322700,12 +323802,20 @@ }, { "sim":51.0, - "partner":"6ak4" + "partner":"6mlh" + }, + { + "sim":51.0, + "partner":"6mlw" }, { "sim":51.0, "partner":"6aej" }, + { + "sim":51.0, + "partner":"6ak4" + }, { "sim":51.0, "partner":"3tai" @@ -322746,10 +323856,6 @@ "sim":51.0, "partner":"5kr6" }, - { - "sim":51.0, - "partner":"6rk2" - }, { "sim":51.0, "partner":"6rjo" @@ -322764,7 +323870,7 @@ }, { "sim":51.0, - "partner":"5uno" + "partner":"6rk2" }, { "sim":51.0, @@ -322780,7 +323886,7 @@ }, { "sim":51.0, - "partner":"4ie7" + "partner":"5uno" }, { "sim":51.0, @@ -322822,6 +323928,10 @@ "sim":51.0, "partner":"4qho" }, + { + "sim":51.0, + "partner":"4ie7" + }, { "sim":51.0, "partner":"5kky" @@ -322850,10 +323960,6 @@ "sim":51.0, "partner":"5yzx" }, - { - "sim":51.0, - "partner":"5kdn" - }, { "sim":51.0, "partner":"5kds" @@ -322864,7 +323970,7 @@ }, { "sim":51.0, - "partner":"6crm" + "partner":"5kdn" }, { "sim":51.0, @@ -322872,15 +323978,11 @@ }, { "sim":51.0, - "partner":"6a37" - }, - { - "sim":51.0, - "partner":"4ids" + "partner":"6crm" }, { "sim":51.0, - "partner":"4jdc" + "partner":"6a37" }, { "sim":51.0, @@ -322934,6 +324036,14 @@ "sim":51.0, "partner":"4lh3" }, + { + "sim":51.0, + "partner":"4ids" + }, + { + "sim":51.0, + "partner":"4jdc" + }, { "sim":51.0, "partner":"5ing" @@ -323008,7 +324118,7 @@ }, { "sim":51.0, - "partner":"5uw0" + "partner":"5uw1" }, { "sim":51.0, @@ -323016,15 +324126,15 @@ }, { "sim":51.0, - "partner":"5uw1" + "partner":"5uw4" }, { "sim":51.0, - "partner":"5uw4" + "partner":"5ux7" }, { "sim":51.0, - "partner":"5ux7" + "partner":"5uw0" }, { "sim":51.0, @@ -323038,10 +324148,6 @@ "sim":51.0, "partner":"4put" }, - { - "sim":51.0, - "partner":"3rsz" - }, { "sim":51.0, "partner":"3rt1" @@ -323070,6 +324176,10 @@ "sim":51.0, "partner":"3nch" }, + { + "sim":51.0, + "partner":"3rsz" + }, { "sim":51.0, "partner":"2wda" @@ -323228,15 +324338,15 @@ }, { "sim":50.0, - "partner":"3m9a" + "partner":"3m8e" }, { "sim":50.0, - "partner":"3m8e" + "partner":"3m8f" }, { "sim":50.0, - "partner":"3m8f" + "partner":"3m9a" }, { "sim":50.0, @@ -323310,10 +324420,6 @@ "sim":50.0, "partner":"6omx" }, - { - "sim":50.0, - "partner":"5zrk" - }, { "sim":50.0, "partner":"5zrl" @@ -323342,6 +324448,10 @@ "sim":50.0, "partner":"5zri" }, + { + "sim":50.0, + "partner":"5zrk" + }, { "sim":50.0, "partner":"2k4m" @@ -323388,11 +324498,11 @@ }, { "sim":50.0, - "partner":"2o4d" + "partner":"3s9f" }, { "sim":50.0, - "partner":"3s9f" + "partner":"2o4d" }, { "sim":50.0, @@ -323400,11 +324510,11 @@ }, { "sim":50.0, - "partner":"3hhq" + "partner":"3f4f" }, { "sim":50.0, - "partner":"3f4f" + "partner":"3hhq" }, { "sim":50.0, @@ -323488,15 +324598,15 @@ }, { "sim":50.0, - "partner":"3oci" + "partner":"1y7o" }, { "sim":50.0, - "partner":"1y7o" + "partner":"3oc3" }, { "sim":50.0, - "partner":"3oc3" + "partner":"3oci" }, { "sim":50.0, @@ -323524,27 +324634,27 @@ }, { "sim":50.0, - "partner":"4njh" + "partner":"4njj" }, { "sim":50.0, - "partner":"4nji" + "partner":"4njk" }, { "sim":50.0, - "partner":"4njj" + "partner":"4njg" }, { "sim":50.0, - "partner":"4njk" + "partner":"1ku1" }, { "sim":50.0, - "partner":"4njg" + "partner":"4njh" }, { "sim":50.0, - "partner":"1ku1" + "partner":"4nji" }, { "sim":50.0, @@ -323560,15 +324670,15 @@ }, { "sim":50.0, - "partner":"1zw9" + "partner":"8vab" }, { "sim":50.0, - "partner":"3c11" + "partner":"1zw9" }, { "sim":50.0, - "partner":"8vab" + "partner":"3c11" }, { "sim":50.0, @@ -323576,11 +324686,11 @@ }, { "sim":50.0, - "partner":"1zwh" + "partner":"8vag" }, { "sim":50.0, - "partner":"8vag" + "partner":"1zwh" }, { "sim":50.0, @@ -323600,15 +324710,15 @@ }, { "sim":50.0, - "partner":"3la7" + "partner":"3la2" }, { "sim":50.0, - "partner":"3la2" + "partner":"3la3" }, { "sim":50.0, - "partner":"3la3" + "partner":"3la7" }, { "sim":50.0, @@ -323622,10 +324732,6 @@ "sim":50.0, "partner":"6n8w" }, - { - "sim":50.0, - "partner":"2ho1" - }, { "sim":50.0, "partner":"2jf9" @@ -323638,6 +324744,10 @@ "sim":50.0, "partner":"2jfa" }, + { + "sim":50.0, + "partner":"2ho1" + }, { "sim":50.0, "partner":"4cnf" @@ -323726,10 +324836,6 @@ "sim":50.0, "partner":"5zga" }, - { - "sim":50.0, - "partner":"4ke6" - }, { "sim":50.0, "partner":"4ke7" @@ -323762,6 +324868,10 @@ "sim":50.0, "partner":"3rli" }, + { + "sim":50.0, + "partner":"4ke6" + }, { "sim":50.0, "partner":"1l2j" @@ -323860,15 +324970,19 @@ }, { "sim":50.0, - "partner":"5uj3" + "partner":"8rwq" }, { "sim":50.0, - "partner":"5uj4" + "partner":"6mnp" }, { "sim":50.0, - "partner":"6mnp" + "partner":"8rwr" + }, + { + "sim":50.0, + "partner":"5uj3" }, { "sim":50.0, @@ -323876,7 +324990,11 @@ }, { "sim":50.0, - "partner":"5ul8" + "partner":"8rws" + }, + { + "sim":50.0, + "partner":"5uj4" }, { "sim":50.0, @@ -323890,6 +325008,10 @@ "sim":50.0, "partner":"6d17" }, + { + "sim":50.0, + "partner":"5ul8" + }, { "sim":50.0, "partner":"6d18" @@ -323906,10 +325028,6 @@ "sim":50.0, "partner":"6qwa" }, - { - "sim":50.0, - "partner":"2vvt" - }, { "sim":50.0, "partner":"6qwb" @@ -323920,15 +325038,15 @@ }, { "sim":50.0, - "partner":"6qwd" + "partner":"2vvt" }, { "sim":50.0, - "partner":"6qwe" + "partner":"6qwd" }, { "sim":50.0, - "partner":"8rwq" + "partner":"6qwe" }, { "sim":50.0, @@ -323962,6 +325080,14 @@ "sim":50.0, "partner":"4cp2" }, + { + "sim":50.0, + "partner":"8rwo" + }, + { + "sim":50.0, + "partner":"8rwp" + }, { "sim":50.0, "partner":"3ois" @@ -324004,11 +325130,7 @@ }, { "sim":50.0, - "partner":"3h26" - }, - { - "sim":50.0, - "partner":"1twz" + "partner":"1tx0" }, { "sim":50.0, @@ -324018,10 +325140,6 @@ "sim":50.0, "partner":"4d8a" }, - { - "sim":50.0, - "partner":"1tx0" - }, { "sim":50.0, "partner":"1tx2" @@ -324134,6 +325252,14 @@ "sim":50.0, "partner":"3h24" }, + { + "sim":50.0, + "partner":"3h26" + }, + { + "sim":50.0, + "partner":"1twz" + }, { "sim":50.0, "partner":"1w4t" @@ -324232,15 +325358,15 @@ }, { "sim":50.0, - "partner":"6q4x" + "partner":"6q4z" }, { "sim":50.0, - "partner":"6q4y" + "partner":"6q4x" }, { "sim":50.0, - "partner":"6q4z" + "partner":"6q4y" }, { "sim":50.0, @@ -324292,35 +325418,35 @@ }, { "sim":50.0, - "partner":"6nxc" + "partner":"8wpj" }, { "sim":50.0, - "partner":"8wpo" + "partner":"8wpq" }, { "sim":50.0, - "partner":"8wph" + "partner":"8wpr" }, { "sim":50.0, - "partner":"8wpi" + "partner":"6nxc" }, { "sim":50.0, - "partner":"8wpj" + "partner":"8wps" }, { "sim":50.0, - "partner":"8wpq" + "partner":"8wpo" }, { "sim":50.0, - "partner":"8wpr" + "partner":"8wph" }, { "sim":50.0, - "partner":"8wps" + "partner":"8wpi" }, { "sim":50.0, @@ -324420,15 +325546,15 @@ }, { "sim":50.0, - "partner":"5eeg" + "partner":"5eeh" }, { "sim":50.0, - "partner":"5jr3" + "partner":"5eeg" }, { "sim":50.0, - "partner":"5eeh" + "partner":"5jr3" }, { "sim":50.0, @@ -324474,14 +325600,6 @@ "sim":50.0, "partner":"6di7" }, - { - "sim":50.0, - "partner":"3dyh" - }, - { - "sim":50.0, - "partner":"4rxd" - }, { "sim":50.0, "partner":"4rxe" @@ -324522,6 +325640,14 @@ "sim":50.0, "partner":"3dyg" }, + { + "sim":50.0, + "partner":"4rxd" + }, + { + "sim":50.0, + "partner":"3dyh" + }, { "sim":50.0, "partner":"5vrd" @@ -324574,17 +325700,13 @@ "sim":50.0, "partner":"6j84" }, - { - "sim":50.0, - "partner":"5xw2" - }, { "sim":50.0, "partner":"4e2p" }, { "sim":50.0, - "partner":"6p3v" + "partner":"5xw2" }, { "sim":50.0, @@ -324618,6 +325740,10 @@ "sim":50.0, "partner":"6p3u" }, + { + "sim":50.0, + "partner":"6p3v" + }, { "sim":50.0, "partner":"5u22" @@ -324686,10 +325812,6 @@ "sim":50.0, "partner":"5z7c" }, - { - "sim":50.0, - "partner":"6oi8" - }, { "sim":50.0, "partner":"4mv1" @@ -324726,6 +325848,10 @@ "sim":50.0, "partner":"6ojh" }, + { + "sim":50.0, + "partner":"6oi8" + }, { "sim":50.0, "partner":"5ws2" @@ -324752,15 +325878,15 @@ }, { "sim":50.0, - "partner":"5v59" + "partner":"4xem" }, { "sim":50.0, - "partner":"4xem" + "partner":"4xeo" }, { "sim":50.0, - "partner":"4xeo" + "partner":"5v59" }, { "sim":50.0, @@ -324818,10 +325944,6 @@ "sim":50.0, "partner":"5uqn" }, - { - "sim":50.0, - "partner":"5wm2" - }, { "sim":50.0, "partner":"5wm3" @@ -324842,6 +325964,10 @@ "sim":50.0, "partner":"5wm7" }, + { + "sim":50.0, + "partner":"5wm2" + }, { "sim":50.0, "partner":"5tkv" @@ -324852,7 +325978,7 @@ }, { "sim":50.0, - "partner":"5m12" + "partner":"6gwg" }, { "sim":50.0, @@ -324860,31 +325986,31 @@ }, { "sim":50.0, - "partner":"6gwf" + "partner":"6gta" }, { "sim":50.0, - "partner":"6gwg" + "partner":"5m16" }, { "sim":50.0, - "partner":"5m16" + "partner":"6gvd" }, { "sim":50.0, - "partner":"6gta" + "partner":"5m0x" }, { "sim":50.0, - "partner":"6gvd" + "partner":"6gx8" }, { "sim":50.0, - "partner":"5m0x" + "partner":"5m12" }, { "sim":50.0, - "partner":"6gx8" + "partner":"6gwf" }, { "sim":50.0, @@ -324902,10 +326028,6 @@ "sim":50.0, "partner":"5wdg" }, - { - "sim":50.0, - "partner":"6j1e" - }, { "sim":50.0, "partner":"6j1i" @@ -324920,7 +326042,7 @@ }, { "sim":50.0, - "partner":"5tsh" + "partner":"6j1e" }, { "sim":50.0, @@ -324930,6 +326052,10 @@ "sim":50.0, "partner":"5tsg" }, + { + "sim":50.0, + "partner":"5tsh" + }, { "sim":50.0, "partner":"5kd2" @@ -325066,10 +326192,6 @@ "sim":50.0, "partner":"3uwx" }, - { - "sim":50.0, - "partner":"4xc6" - }, { "sim":50.0, "partner":"4xc7" @@ -325093,6 +326215,10 @@ { "sim":50.0, "partner":"5cjw" + }, + { + "sim":50.0, + "partner":"4xc6" } ], "struct_thr_sim_designed":[ @@ -325107,7 +326233,7 @@ }, "seq_max_sim_natural":{ "sim":62.0, - "partner":"5lj7" + "partner":"5lil" }, "struct_max_sim_designed":{ "sim":0.9140999913, @@ -325173,101 +326299,101 @@ ], "subtitle":"Crystal structure of the computationally designed cake2 protein", "tags":[ - "computationally designed", - "beta-propeller", - "symmetrical", "de novo protein", + "symmetrical", + "beta-propeller", + "computationally designed", "repeat protein" ], "keywords":[ - "intermediate", - "6tjf", - "gene", - "available", - "6tjd", - "explained", - "crystallography", - "designed", - "explanation", - "provide", - "6tjg", - "potential", - "show", - "reconstruction", - "findings", + "6tjc", "adopt", + "structural", "repeat", - "diversity", - "database", - "duplication", - "even", - "symmetries", - "generating", - "6tjh", - "allows", - "proteins", - "investigated", - "propellers", - "process", - "variants", + "show", + "characterised", "number", - "highly", - "ancestral", - "nature", - "symmetric", - "evolutionary", - "6tji", - "permit", - "assemble", - "odd", + "6tjd", + "rotational", "symmetrical", + "numbers", + "protein", + "study", + "given", + "changes", + "explanation", + "6tje", + "forms", + "6tji", "bank", + "two", + "accession", + "6tjb", + "stable", + "using", + "6tjh", "perfectly", - "natural", - "solution", - "size", - "fusion", + "distorted", + "gene", "transition", - "blade", - "numbers", + "proteins", + "process", + "capable", + "size", + "ancestral", + "explained", + "highly", + "available", + "found", "created", - "rotational", - "data", + "6tjg", + "duplication", + "computational", + "design", "propeller", - "common", - "6tjb", - "changes", + "fusion", + "even", + "named", + "natural", + "different", + "potential", + "fold", + "diversity", "template", - "6tje", + "wide", + "symmetric", + "cake", + "solution", + "permit", + "allows", + "sequence", + "plasticity", + "common", + "identical", + "generating", + "odd", + "evolutionary", + "designed", + "6tjf", + "investigated", + "variants", "observed", - "design", + "reconstruction", + "symmetries", "apparent", - "using", - "sequence", - "structural", - "distorted", - "study", - "stable", - "wide", - "named", - "fold", - "sufficient", - "accession", - "different", "copies", - "capable", - "found", - "two", - "6tjc", - "protein", - "given", - "identical", - "characterised", - "cake", - "computational", + "provide", + "findings", + "crystallography", + "propellers", + "nature", + "intermediate", "internal", - "forms", - "plasticity" + "blade", + "sufficient", + "data", + "database", + "assemble" ], "release_date":"2020-05-06", "publication":"\"Structural plasticity of a designer protein sheds light on beta-propeller protein evolution\", Febs J., 288, 530-545", @@ -325344,15 +326470,15 @@ }, { "sim":129.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":129.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":129.0, - "partner":"7ax2" + "partner":"7ax0" }, { "sim":124.0, @@ -325360,15 +326486,15 @@ }, { "sim":113.0, - "partner":"8prr" + "partner":"8prf" }, { "sim":113.0, - "partner":"8pre" + "partner":"8prr" }, { "sim":113.0, - "partner":"8prf" + "partner":"8pre" }, { "sim":108.0, @@ -325390,6 +326516,10 @@ "sim":0.9850999713, "partner":"6tjd" }, + { + "sim":0.9962999821, + "partner":"6tji" + }, { "sim":0.9850999713, "partner":"6tjg" @@ -325398,22 +326528,18 @@ "sim":0.9880999923, "partner":"6tje" }, - { - "sim":0.9994999766, - "partner":"6tjh" - }, { "sim":0.9588999748, "partner":"8prb" }, - { - "sim":0.9962999821, - "partner":"6tji" - }, { "sim":0.969900012, "partner":"8pr9" }, + { + "sim":0.9994999766, + "partner":"6tjh" + }, { "sim":0.9589999914, "partner":"8pra" @@ -325506,101 +326632,101 @@ ], "subtitle":"Crystal structure of the computationally designed cake3 protein", "tags":[ - "computationally designed", - "beta-propeller", - "symmetrical", "de novo protein", + "symmetrical", + "beta-propeller", + "computationally designed", "repeat protein" ], "keywords":[ - "intermediate", - "6tjf", - "gene", - "available", - "6tjd", - "explained", - "crystallography", - "designed", - "explanation", - "provide", - "6tjg", - "potential", - "show", - "reconstruction", - "findings", + "6tjc", "adopt", + "structural", "repeat", - "diversity", - "database", - "duplication", - "even", - "symmetries", - "generating", - "6tjh", - "allows", - "proteins", - "investigated", - "propellers", - "process", - "variants", + "show", + "characterised", "number", - "highly", - "ancestral", - "nature", - "symmetric", - "evolutionary", - "6tji", - "permit", - "assemble", - "odd", + "6tjd", + "rotational", "symmetrical", + "numbers", + "protein", + "study", + "given", + "changes", + "explanation", + "6tje", + "forms", + "6tji", "bank", + "two", + "accession", + "6tjb", + "stable", + "using", + "6tjh", "perfectly", - "natural", - "solution", - "size", - "fusion", + "distorted", + "gene", "transition", - "blade", - "numbers", + "proteins", + "process", + "capable", + "size", + "ancestral", + "explained", + "highly", + "available", + "found", "created", - "rotational", - "data", + "6tjg", + "duplication", + "computational", + "design", "propeller", - "common", - "6tjb", - "changes", + "fusion", + "even", + "named", + "natural", + "different", + "potential", + "fold", + "diversity", "template", - "6tje", + "wide", + "symmetric", + "cake", + "solution", + "permit", + "allows", + "sequence", + "plasticity", + "common", + "identical", + "generating", + "odd", + "evolutionary", + "designed", + "6tjf", + "investigated", + "variants", "observed", - "design", + "reconstruction", + "symmetries", "apparent", - "using", - "sequence", - "structural", - "distorted", - "study", - "stable", - "wide", - "named", - "fold", - "sufficient", - "accession", - "different", "copies", - "capable", - "found", - "two", - "6tjc", - "protein", - "given", - "identical", - "characterised", - "cake", - "computational", + "provide", + "findings", + "crystallography", + "propellers", + "nature", + "intermediate", "internal", - "forms", - "plasticity" + "blade", + "sufficient", + "data", + "database", + "assemble" ], "release_date":"2020-05-06", "publication":"\"Structural plasticity of a designer protein sheds light on beta-propeller protein evolution\", Febs J., 288, 530-545", @@ -325665,15 +326791,15 @@ }, { "sim":188.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":188.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":188.0, - "partner":"7ax2" + "partner":"7ax0" }, { "sim":184.0, @@ -325697,15 +326823,15 @@ }, { "sim":124.0, - "partner":"8prr" + "partner":"8prf" }, { "sim":124.0, - "partner":"8pre" + "partner":"8prr" }, { "sim":124.0, - "partner":"8prf" + "partner":"8pre" } ], "seq_thr_sim_natural":[ @@ -325875,101 +327001,101 @@ ], "subtitle":"Crystal structure of the computationally designed cake4 protein", "tags":[ - "computationally designed", - "beta-propeller", - "symmetrical", "de novo protein", + "symmetrical", + "beta-propeller", + "computationally designed", "repeat protein" ], "keywords":[ - "intermediate", - "6tjf", - "gene", - "available", - "6tjd", - "explained", - "crystallography", - "designed", - "explanation", - "provide", - "6tjg", - "potential", - "show", - "reconstruction", - "findings", + "6tjc", "adopt", + "structural", "repeat", - "diversity", - "database", - "duplication", - "even", - "symmetries", - "generating", - "6tjh", - "allows", - "proteins", - "investigated", - "propellers", - "process", - "variants", + "show", + "characterised", "number", - "highly", - "ancestral", - "nature", - "symmetric", - "evolutionary", - "6tji", - "permit", - "assemble", - "odd", + "6tjd", + "rotational", "symmetrical", + "numbers", + "protein", + "study", + "given", + "changes", + "explanation", + "6tje", + "forms", + "6tji", "bank", + "two", + "accession", + "6tjb", + "stable", + "using", + "6tjh", "perfectly", - "natural", - "solution", - "size", - "fusion", + "distorted", + "gene", "transition", - "blade", - "numbers", + "proteins", + "process", + "capable", + "size", + "ancestral", + "explained", + "highly", + "available", + "found", "created", - "rotational", - "data", + "6tjg", + "duplication", + "computational", + "design", "propeller", - "common", - "6tjb", - "changes", + "fusion", + "even", + "named", + "natural", + "different", + "potential", + "fold", + "diversity", "template", - "6tje", + "wide", + "symmetric", + "cake", + "solution", + "permit", + "allows", + "sequence", + "plasticity", + "common", + "identical", + "generating", + "odd", + "evolutionary", + "designed", + "6tjf", + "investigated", + "variants", "observed", - "design", + "reconstruction", + "symmetries", "apparent", - "using", - "sequence", - "structural", - "distorted", - "study", - "stable", - "wide", - "named", - "fold", - "sufficient", - "accession", - "different", "copies", - "capable", - "found", - "two", - "6tjc", - "protein", - "given", - "identical", - "characterised", - "cake", - "computational", + "provide", + "findings", + "crystallography", + "propellers", + "nature", + "intermediate", "internal", - "forms", - "plasticity" + "blade", + "sufficient", + "data", + "database", + "assemble" ], "release_date":"2020-05-06", "publication":"\"Structural plasticity of a designer protein sheds light on beta-propeller protein evolution\", Febs J., 288, 530-545", @@ -326034,15 +327160,15 @@ }, { "sim":247.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":247.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":247.0, - "partner":"7ax2" + "partner":"7ax0" }, { "sim":244.0, @@ -326066,15 +327192,15 @@ }, { "sim":124.0, - "partner":"8prr" + "partner":"8prf" }, { "sim":124.0, - "partner":"8pre" + "partner":"8prr" }, { "sim":124.0, - "partner":"8prf" + "partner":"8pre" } ], "seq_thr_sim_natural":[ @@ -326240,101 +327366,101 @@ ], "subtitle":"Crystal structure of the computationally designed cake5 protein", "tags":[ - "computationally designed", - "beta-propeller", - "symmetrical", "de novo protein", + "symmetrical", + "beta-propeller", + "computationally designed", "repeat protein" ], "keywords":[ - "intermediate", - "6tjf", - "gene", - "available", - "6tjd", - "explained", - "crystallography", - "designed", - "explanation", - "provide", - "6tjg", - "potential", - "show", - "reconstruction", - "findings", + "6tjc", "adopt", + "structural", "repeat", - "diversity", - "database", - "duplication", - "even", - "symmetries", - "generating", - "6tjh", - "allows", - "proteins", - "investigated", - "propellers", - "process", - "variants", + "show", + "characterised", "number", - "highly", - "ancestral", - "nature", - "symmetric", - "evolutionary", - "6tji", - "permit", - "assemble", - "odd", + "6tjd", + "rotational", "symmetrical", + "numbers", + "protein", + "study", + "given", + "changes", + "explanation", + "6tje", + "forms", + "6tji", "bank", + "two", + "accession", + "6tjb", + "stable", + "using", + "6tjh", "perfectly", - "natural", - "solution", - "size", - "fusion", + "distorted", + "gene", "transition", - "blade", - "numbers", + "proteins", + "process", + "capable", + "size", + "ancestral", + "explained", + "highly", + "available", + "found", "created", - "rotational", - "data", + "6tjg", + "duplication", + "computational", + "design", "propeller", - "common", - "6tjb", - "changes", + "fusion", + "even", + "named", + "natural", + "different", + "potential", + "fold", + "diversity", "template", - "6tje", + "wide", + "symmetric", + "cake", + "solution", + "permit", + "allows", + "sequence", + "plasticity", + "common", + "identical", + "generating", + "odd", + "evolutionary", + "designed", + "6tjf", + "investigated", + "variants", "observed", - "design", + "reconstruction", + "symmetries", "apparent", - "using", - "sequence", - "structural", - "distorted", - "study", - "stable", - "wide", - "named", - "fold", - "sufficient", - "accession", - "different", "copies", - "capable", - "found", - "two", - "6tjc", - "protein", - "given", - "identical", - "characterised", - "cake", - "computational", + "provide", + "findings", + "crystallography", + "propellers", + "nature", + "intermediate", "internal", - "forms", - "plasticity" + "blade", + "sufficient", + "data", + "database", + "assemble" ], "release_date":"2020-05-06", "publication":"\"Structural plasticity of a designer protein sheds light on beta-propeller protein evolution\", Febs J., 288, 530-545", @@ -326395,15 +327521,15 @@ }, { "sim":303.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":303.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":303.0, - "partner":"7ax2" + "partner":"7ax0" }, { "sim":269.0, @@ -326431,15 +327557,15 @@ }, { "sim":124.0, - "partner":"8prr" + "partner":"8prf" }, { "sim":124.0, - "partner":"8pre" + "partner":"8prr" }, { "sim":124.0, - "partner":"8prf" + "partner":"8pre" } ], "seq_thr_sim_natural":[ @@ -326593,101 +327719,101 @@ ], "subtitle":"Crystal structure of the computationally designed cake6 protein", "tags":[ - "computationally designed", - "beta-propeller", - "symmetrical", "de novo protein", + "symmetrical", + "beta-propeller", + "computationally designed", "repeat protein" ], "keywords":[ - "intermediate", - "6tjf", - "gene", - "available", - "6tjd", - "explained", - "crystallography", - "designed", - "explanation", - "provide", - "6tjg", - "potential", - "show", - "reconstruction", - "findings", + "6tjc", "adopt", + "structural", "repeat", - "diversity", - "database", - "duplication", - "even", - "symmetries", - "generating", - "6tjh", - "allows", - "proteins", - "investigated", - "propellers", - "process", - "variants", + "show", + "characterised", "number", - "highly", - "ancestral", - "nature", - "symmetric", - "evolutionary", - "6tji", - "permit", - "assemble", - "odd", + "6tjd", + "rotational", "symmetrical", + "numbers", + "protein", + "study", + "given", + "changes", + "explanation", + "6tje", + "forms", + "6tji", "bank", + "two", + "accession", + "6tjb", + "stable", + "using", + "6tjh", "perfectly", - "natural", - "solution", - "size", - "fusion", + "distorted", + "gene", "transition", - "blade", - "numbers", + "proteins", + "process", + "capable", + "size", + "ancestral", + "explained", + "highly", + "available", + "found", "created", - "rotational", - "data", + "6tjg", + "duplication", + "computational", + "design", "propeller", - "common", - "6tjb", - "changes", + "fusion", + "even", + "named", + "natural", + "different", + "potential", + "fold", + "diversity", "template", - "6tje", + "wide", + "symmetric", + "cake", + "solution", + "permit", + "allows", + "sequence", + "plasticity", + "common", + "identical", + "generating", + "odd", + "evolutionary", + "designed", + "6tjf", + "investigated", + "variants", "observed", - "design", + "reconstruction", + "symmetries", "apparent", - "using", - "sequence", - "structural", - "distorted", - "study", - "stable", - "wide", - "named", - "fold", - "sufficient", - "accession", - "different", "copies", - "capable", - "found", - "two", - "6tjc", - "protein", - "given", - "identical", - "characterised", - "cake", - "computational", + "provide", + "findings", + "crystallography", + "propellers", + "nature", + "intermediate", "internal", - "forms", - "plasticity" + "blade", + "sufficient", + "data", + "database", + "assemble" ], "release_date":"2020-05-06", "publication":"\"Structural plasticity of a designer protein sheds light on beta-propeller protein evolution\", Febs J., 288, 530-545", @@ -326744,15 +327870,15 @@ }, { "sim":362.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":362.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":362.0, - "partner":"7ax2" + "partner":"7ax0" }, { "sim":354.0, @@ -326784,15 +327910,15 @@ }, { "sim":124.0, - "partner":"8prr" + "partner":"8prf" }, { "sim":124.0, - "partner":"8pre" + "partner":"8prr" }, { "sim":124.0, - "partner":"8prf" + "partner":"8pre" } ], "seq_thr_sim_natural":[ @@ -326858,10 +327984,6 @@ } ], "struct_thr_sim_designed":[ - { - "sim":0.9732999802, - "partner":"6tji" - }, { "sim":0.993900001, "partner":"6tjh" @@ -326869,6 +327991,10 @@ { "sim":0.976000011, "partner":"6tjg" + }, + { + "sim":0.9732999802, + "partner":"6tji" } ], "struct_thr_sim_natural":[ @@ -326946,101 +328072,101 @@ ], "subtitle":"Crystal structure of the computationally designed cake8 protein", "tags":[ - "computationally designed", - "beta-propeller", - "symmetrical", "de novo protein", + "symmetrical", + "beta-propeller", + "computationally designed", "repeat protein" ], "keywords":[ - "intermediate", - "6tjf", - "gene", - "available", - "6tjd", - "explained", - "crystallography", - "designed", - "explanation", - "provide", - "6tjg", - "potential", - "show", - "reconstruction", - "findings", + "6tjc", "adopt", + "structural", "repeat", - "diversity", - "database", - "duplication", - "even", - "symmetries", - "generating", - "6tjh", - "allows", - "proteins", - "investigated", - "propellers", - "process", - "variants", + "show", + "characterised", "number", - "highly", - "ancestral", - "nature", - "symmetric", - "evolutionary", - "6tji", - "permit", - "assemble", - "odd", + "6tjd", + "rotational", "symmetrical", + "numbers", + "protein", + "study", + "given", + "changes", + "explanation", + "6tje", + "forms", + "6tji", "bank", + "two", + "accession", + "6tjb", + "stable", + "using", + "6tjh", "perfectly", - "natural", - "solution", - "size", - "fusion", + "distorted", + "gene", "transition", - "blade", - "numbers", + "proteins", + "process", + "capable", + "size", + "ancestral", + "explained", + "highly", + "available", + "found", "created", - "rotational", - "data", + "6tjg", + "duplication", + "computational", + "design", "propeller", - "common", - "6tjb", - "changes", + "fusion", + "even", + "named", + "natural", + "different", + "potential", + "fold", + "diversity", "template", - "6tje", + "wide", + "symmetric", + "cake", + "solution", + "permit", + "allows", + "sequence", + "plasticity", + "common", + "identical", + "generating", + "odd", + "evolutionary", + "designed", + "6tjf", + "investigated", + "variants", "observed", - "design", + "reconstruction", + "symmetries", "apparent", - "using", - "sequence", - "structural", - "distorted", - "study", - "stable", - "wide", - "named", - "fold", - "sufficient", - "accession", - "different", "copies", - "capable", - "found", - "two", - "6tjc", - "protein", - "given", - "identical", - "characterised", - "cake", - "computational", + "provide", + "findings", + "crystallography", + "propellers", + "nature", + "intermediate", "internal", - "forms", - "plasticity" + "blade", + "sufficient", + "data", + "database", + "assemble" ], "release_date":"2020-05-06", "publication":"\"Structural plasticity of a designer protein sheds light on beta-propeller protein evolution\", Febs J., 288, 530-545", @@ -327089,15 +328215,15 @@ }, { "sim":477.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":477.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":477.0, - "partner":"7ax2" + "partner":"7ax0" }, { "sim":460.0, @@ -327137,15 +328263,15 @@ }, { "sim":124.0, - "partner":"8prr" + "partner":"8prf" }, { "sim":124.0, - "partner":"8pre" + "partner":"8prr" }, { "sim":124.0, - "partner":"8prf" + "partner":"8pre" } ], "seq_thr_sim_natural":[ @@ -327288,101 +328414,101 @@ ], "subtitle":"Crystal structure of the computationally designed cake9 protein", "tags":[ - "computationally designed", - "beta-propeller", - "symmetrical", "de novo protein", + "symmetrical", + "beta-propeller", + "computationally designed", "repeat protein" ], "keywords":[ - "intermediate", - "6tjf", - "gene", - "available", - "6tjd", - "explained", - "crystallography", - "designed", - "explanation", - "provide", - "6tjg", - "potential", - "show", - "reconstruction", - "findings", + "6tjc", "adopt", + "structural", "repeat", - "diversity", - "database", - "duplication", - "even", - "symmetries", - "generating", - "6tjh", - "allows", - "proteins", - "investigated", - "propellers", - "process", - "variants", + "show", + "characterised", "number", - "highly", - "ancestral", - "nature", - "symmetric", - "evolutionary", - "6tji", - "permit", - "assemble", - "odd", + "6tjd", + "rotational", "symmetrical", + "numbers", + "protein", + "study", + "given", + "changes", + "explanation", + "6tje", + "forms", + "6tji", "bank", + "two", + "accession", + "6tjb", + "stable", + "using", + "6tjh", "perfectly", - "natural", - "solution", - "size", - "fusion", + "distorted", + "gene", "transition", - "blade", - "numbers", + "proteins", + "process", + "capable", + "size", + "ancestral", + "explained", + "highly", + "available", + "found", "created", - "rotational", - "data", + "6tjg", + "duplication", + "computational", + "design", "propeller", - "common", - "6tjb", - "changes", + "fusion", + "even", + "named", + "natural", + "different", + "potential", + "fold", + "diversity", "template", - "6tje", + "wide", + "symmetric", + "cake", + "solution", + "permit", + "allows", + "sequence", + "plasticity", + "common", + "identical", + "generating", + "odd", + "evolutionary", + "designed", + "6tjf", + "investigated", + "variants", "observed", - "design", + "reconstruction", + "symmetries", "apparent", - "using", - "sequence", - "structural", - "distorted", - "study", - "stable", - "wide", - "named", - "fold", - "sufficient", - "accession", - "different", "copies", - "capable", - "found", - "two", - "6tjc", - "protein", - "given", - "identical", - "characterised", - "cake", - "computational", + "provide", + "findings", + "crystallography", + "propellers", + "nature", + "intermediate", "internal", - "forms", - "plasticity" + "blade", + "sufficient", + "data", + "database", + "assemble" ], "release_date":"2020-05-06", "publication":"\"Structural plasticity of a designer protein sheds light on beta-propeller protein evolution\", Febs J., 288, 530-545", @@ -327427,15 +328553,15 @@ }, { "sim":536.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":536.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":536.0, - "partner":"7ax2" + "partner":"7ax0" }, { "sim":524.0, @@ -327479,15 +328605,15 @@ }, { "sim":124.0, - "partner":"8prr" + "partner":"8prf" }, { "sim":124.0, - "partner":"8pre" + "partner":"8prr" }, { "sim":124.0, - "partner":"8prf" + "partner":"8pre" } ], "seq_thr_sim_natural":[ @@ -327637,101 +328763,101 @@ ], "subtitle":"Crystal structure of the computationally designed cake10 protein", "tags":[ - "computationally designed", - "beta-propeller", - "symmetrical", "de novo protein", + "symmetrical", + "beta-propeller", + "computationally designed", "repeat protein" ], "keywords":[ - "intermediate", - "6tjf", - "gene", - "available", - "6tjd", - "explained", - "crystallography", - "designed", - "explanation", - "provide", - "6tjg", - "potential", - "show", - "reconstruction", - "findings", + "6tjc", "adopt", + "structural", "repeat", - "diversity", - "database", - "duplication", - "even", - "symmetries", - "generating", - "6tjh", - "allows", - "proteins", - "investigated", - "propellers", - "process", - "variants", + "show", + "characterised", "number", - "highly", - "ancestral", - "nature", - "symmetric", - "evolutionary", - "6tji", - "permit", - "assemble", - "odd", + "6tjd", + "rotational", "symmetrical", + "numbers", + "protein", + "study", + "given", + "changes", + "explanation", + "6tje", + "forms", + "6tji", "bank", + "two", + "accession", + "6tjb", + "stable", + "using", + "6tjh", "perfectly", - "natural", - "solution", - "size", - "fusion", + "distorted", + "gene", "transition", - "blade", - "numbers", + "proteins", + "process", + "capable", + "size", + "ancestral", + "explained", + "highly", + "available", + "found", "created", - "rotational", - "data", + "6tjg", + "duplication", + "computational", + "design", "propeller", - "common", - "6tjb", - "changes", + "fusion", + "even", + "named", + "natural", + "different", + "potential", + "fold", + "diversity", "template", - "6tje", + "wide", + "symmetric", + "cake", + "solution", + "permit", + "allows", + "sequence", + "plasticity", + "common", + "identical", + "generating", + "odd", + "evolutionary", + "designed", + "6tjf", + "investigated", + "variants", "observed", - "design", + "reconstruction", + "symmetries", "apparent", - "using", - "sequence", - "structural", - "distorted", - "study", - "stable", - "wide", - "named", - "fold", - "sufficient", - "accession", - "different", "copies", - "capable", - "found", - "two", - "6tjc", - "protein", - "given", - "identical", - "characterised", - "cake", - "computational", + "provide", + "findings", + "crystallography", + "propellers", + "nature", + "intermediate", "internal", - "forms", - "plasticity" + "blade", + "sufficient", + "data", + "database", + "assemble" ], "release_date":"2020-05-06", "publication":"\"Structural plasticity of a designer protein sheds light on beta-propeller protein evolution\", Febs J., 288, 530-545", @@ -327776,15 +328902,15 @@ }, { "sim":529.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":529.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":529.0, - "partner":"7ax2" + "partner":"7ax0" }, { "sim":517.0, @@ -327828,15 +328954,15 @@ }, { "sim":124.0, - "partner":"8prr" + "partner":"8prf" }, { "sim":124.0, - "partner":"8pre" + "partner":"8prr" }, { "sim":124.0, - "partner":"8prf" + "partner":"8pre" }, { "sim":50.0, @@ -328023,116 +329149,116 @@ ], "subtitle":"Crystal structure of a de novo designed hexameric helical-bundle protein", "tags":[ - "computational protein design", + "helical bundle", + "biosynthetic protein", "pore", "de novo protein", - "hexamer", - "helical bundle", - "biosynthetic protein" + "computational protein design", + "hexamer" ], "keywords":[ - "concentric", - "opens", - "fluorophores", - "matches", - "channels", - "ions", - "challenge", - "door", - "expressed", - "roles", - "crystal", - "alexa", - "fluor", + "biotechnological", + "biotinylated", + "488", + "key", "show", - "synthetic", - "pores", - "passage", - "structure", - "structurally", - "sequencing", - "however", - "modification", - "proteins", - "membrane", - "models", - "dna", - "enables", - "de", "outstanding", - "produce", - "amphiphilic", - "rings", + "functionally", "pore", - "processes", - "resulting", - "remains", - "liposomes", + "roles", + "model", + "protein", + "insect", "vitro", - "occurring", - "ability", + "across", + "microscopy", + "novo", + "cells", "match", + "forms", + "amphiphilic", + "two", + "variety", + "applications", + "recent", + "crystal", + "stable", + "door", + "using", + "occurring", + "monodisperse", "enough", - "structures", - "naturally", - "biotechnological", - "potassium", - "biotinylated", - "transmembrane", - "form", - "functionally", - "designer", - "considerable", - "entrance", + "enables", + "however", + "formed", + "interest", + "creation", + "dna", + "biological", + "specific", "incorporated", + "matches", + "entrance", + "conducting", + "proteins", "large", - "chemical", - "report", + "capable", + "ions", "blocked", + "alexa", + "found", + "chemical", + "electrophysiology", + "computational", "1", - "redesigning", - "interest", - "conducting", - "closely", - "synthesis", - "specific", + "concentric", "advances", - "488", - "insect", "design", - "model", - "using", - "applications", - "nanopore", - "selectively", - "across", - "recent", - "high", - "biological", - "key", - "cells", "sodium", - "ion", - "fundamental", - "monodisperse", - "novo", - "stable", - "wide", + "produce", + "processes", + "nanopore", + "synthesis", "experiments", + "selectivity", + "wide", + "liposomes", + "ability", + "sequencing", + "fluor", + "designer", + "selectively", + "channels", "peptides", + "potassium", + "pores", + "fundamental", + "form", + "fluorophores", + "models", + "naturally", + "modification", + "transmembrane", + "opens", + "structurally", + "structures", + "de", + "expressed", + "remains", + "structure", + "synthetic", + "report", + "resulting", + "closely", + "ion", + "membrane", + "redesigning", "enable", - "capable", - "found", - "selectivity", - "two", - "creation", - "protein", - "microscopy", - "electrophysiology", - "variety", - "computational", - "formed", - "forms" + "passage", + "considerable", + "high", + "rings", + "challenge" ], "release_date":"2020-04-29", "publication":"\"Computational design of transmembrane pores\", Nature, 585, 129-134", @@ -328238,8 +329364,8 @@ "tags":[ "computational design", "de novo protein", - "heterochiral peptide", - "immunotherapy" + "immunotherapy", + "heterochiral peptide" ], "keywords":[ "description", @@ -328342,9 +329468,9 @@ "subtitle":"Kemp eliminase hg3.17 mutant q50m, e47n, n300d complexed with transition state analog 6-nitrobenzotriazole", "tags":[ "de novo protein", - "enzyme", "protein design", - "kemp eliminase" + "kemp eliminase", + "enzyme" ], "keywords":[ "description", @@ -328385,19 +329511,19 @@ }, { "sim":653.0, - "partner":"6ss3" + "partner":"6sry" }, { "sim":653.0, - "partner":"6sry" + "partner":"6ss3" }, { "sim":652.0, - "partner":"6srw" + "partner":"6srz" }, { "sim":652.0, - "partner":"6srz" + "partner":"6srw" } ], "seq_thr_sim_natural":[ @@ -328415,11 +329541,11 @@ }, { "sim":561.0, - "partner":"1gok" + "partner":"1k6a" }, { "sim":561.0, - "partner":"1k6a" + "partner":"1gok" }, { "sim":561.0, @@ -328523,27 +329649,27 @@ }, { "sim":237.0, - "partner":"1isv" + "partner":"5gqd" }, { "sim":237.0, - "partner":"1isw" + "partner":"1isv" }, { "sim":237.0, - "partner":"5gqd" + "partner":"1xyf" }, { "sim":237.0, - "partner":"1isx" + "partner":"5gqe" }, { "sim":237.0, - "partner":"1xyf" + "partner":"1isw" }, { "sim":237.0, - "partner":"5gqe" + "partner":"1isx" }, { "sim":237.0, @@ -328577,10 +329703,6 @@ "sim":236.0, "partner":"1e0v" }, - { - "sim":236.0, - "partner":"2d23" - }, { "sim":236.0, "partner":"2d24" @@ -328598,12 +329720,8 @@ "partner":"2d22" }, { - "sim":235.0, - "partner":"1v0k" - }, - { - "sim":235.0, - "partner":"3wue" + "sim":236.0, + "partner":"2d23" }, { "sim":235.0, @@ -328633,6 +329751,14 @@ "sim":235.0, "partner":"3wub" }, + { + "sim":235.0, + "partner":"1v0k" + }, + { + "sim":235.0, + "partner":"3wue" + }, { "sim":234.0, "partner":"1xas" @@ -328729,25 +329855,21 @@ "sim":174.0, "partner":"4xx6" }, - { - "sim":171.0, - "partner":"1vbu" - }, { "sim":171.0, "partner":"1vbr" }, { - "sim":169.0, - "partner":"3nj3" + "sim":171.0, + "partner":"1vbu" }, { "sim":169.0, "partner":"3niy" }, { - "sim":166.0, - "partner":"3w24" + "sim":169.0, + "partner":"3nj3" }, { "sim":166.0, @@ -328762,13 +329884,17 @@ "partner":"3w29" }, { - "sim":164.0, - "partner":"3w25" + "sim":166.0, + "partner":"3w24" }, { "sim":164.0, "partner":"3w26" }, + { + "sim":164.0, + "partner":"3w25" + }, { "sim":154.0, "partner":"1xys" @@ -328799,11 +329925,11 @@ }, { "sim":151.0, - "partner":"5xzu" + "partner":"5xzo" }, { "sim":151.0, - "partner":"5xzo" + "partner":"5xzu" }, { "sim":148.0, @@ -328859,11 +329985,11 @@ }, { "sim":142.0, - "partner":"5d4y" + "partner":"5ay7" }, { "sim":142.0, - "partner":"5ay7" + "partner":"5d4y" }, { "sim":141.0, @@ -328941,10 +330067,6 @@ "sim":126.0, "partner":"2fgl" }, - { - "sim":126.0, - "partner":"5eff" - }, { "sim":126.0, "partner":"4qce" @@ -328961,21 +330083,25 @@ "sim":126.0, "partner":"4qdm" }, + { + "sim":126.0, + "partner":"5eff" + }, { "sim":125.0, "partner":"4l4p" }, { "sim":125.0, - "partner":"5efd" + "partner":"5xc0" }, { "sim":125.0, - "partner":"5xc1" + "partner":"5efd" }, { "sim":125.0, - "partner":"5xc0" + "partner":"5xc1" }, { "sim":124.0, @@ -329039,15 +330165,15 @@ }, { "sim":71.0, - "partner":"2w5f" + "partner":"2wze" }, { "sim":71.0, - "partner":"2wze" + "partner":"2wys" }, { "sim":71.0, - "partner":"2wys" + "partner":"2w5f" }, { "sim":51.0, @@ -329188,90 +330314,90 @@ "tags":[ "computational design", "de novo protein", - "heterochiral peptide", - "immunotherapy" + "immunotherapy", + "heterochiral peptide" ], "keywords":[ + "elucidation", "largely", - "generalizable", - "comprehensive", - "go", - "programmed", - "immune", - "current", - "methods", + "finally", "limited", - "sampling", - "applicability", - "interactions", - "bind", - "exploits", + "especially", + "key", + "methods", + "well", + "generalizable", + "scoring", + "rapidly", + "framework", "assess", - "designing", - "inhibitors", + "new", + "various", + "protein", + "topologies", + "binding", + "confirmed", + "novo", + "power", + "bioactive", + "two", + "terms", "however", + "exploits", + "interest", + "showcase", + "effect", + "comprehensive", + "endogenous", "cyclic", - "interaction", - "elucidation", - "power", - "cell", - "de", - "oncology", - "checkpoint", - "rapidly", - "death", - "finally", + "bind", + "approach", + "growing", "small", - "difficult", - "beyond", - "heterochiral", + "computational", + "1", + "blocking", + "applicability", + "surface", + "designing", + "design", + "sampling", + "energy", + "current", "therapeutics", - "structures", "natural", + "targeting", + "rosetta", + "beyond", + "immune", + "cell", + "death", + "interaction", + "backbone", + "peptides", + "checkpoint", + "developed", + "evaluation", + "structures", + "traditional", "suitable", - "molecules", + "de", "performed", - "targeting", - "framework", "report", + "nmr", + "interactions", + "biophysical", + "inhibitors", "class", - "topologies", - "1", - "acids", - "interest", - "growing", + "oncology", + "programmed", + "molecules", "advantages", - "design", - "scoring", - "effect", - "nmr", - "surface", - "energy", - "key", - "endogenous", - "bioactive", - "showcase", - "blocking", - "approach", + "heterochiral", + "difficult", + "acids", "composition", - "novo", - "rosetta", - "peptides", - "well", - "confirmed", - "especially", - "two", - "terms", - "evaluation", - "protein", - "backbone", - "various", - "computational", - "binding", - "developed", - "biophysical", - "traditional", - "new" + "go" ], "release_date":"2021-01-27", "publication":"\"Target-templated de novo design of macrocyclic d-\/l-peptides: discovery of drug-like inhibitors of PD-1\", Chem Sci, 12, 5164-5170", @@ -329434,10 +330560,10 @@ ], "subtitle":"Cryo-em structure of a de novo designed 16-helix transmembrane nanopore, tmhc8_r", "tags":[ - "rosetta", "de novo protein", - "pore", - "transmembrane" + "transmembrane", + "rosetta", + "pore" ], "keywords":[ "description", @@ -329478,11 +330604,11 @@ }, { "sim":247.0, - "partner":"6vfh" + "partner":"6vfk" }, { "sim":247.0, - "partner":"6vfk" + "partner":"6vfh" }, { "sim":113.0, @@ -329574,86 +330700,86 @@ "helix" ], "keywords":[ - "confirm", + "engineering", + "molecular", + "role", + "hydrophobic", + "hyperstable", + "show", + "presence", + "substitutions", + "surprising", + "within", "results", + "new", + "residue", + "lys18", + "positions", + "stabilization", + "pair", + "thermodynamic", + "b", + "exquisite", + "subsequent", + "depends", + "confirm", + "crystal", + "possibility", + "simulations", + "donor", + "favorably", + "bundles", + "consider", + "nearby", + "carefully", "stabilizing", - "possibilities", - "character", - "suggest", - "still", - "substitutions", + "involving", + "purposes", + "relative", + "residues", + "helix", + "primarily", + "depending", "interact", - "smaller", - "nearby", - "crystal", - "show", - "interactions", + "large", + "suggest", + "glu10", + "possibilities", + "extent", + "suggesting", + "facilitate", + "bundle", "c", - "surprising", + "highlight", + "need", + "identity", + "proximity", + "still", + "experiments", + "complexity", + "f", + "14", + "nonpolar", + "character", + "lys7", "interaction", - "synergistic", "allows", - "consider", - "suggesting", - "lys7", - "presence", - "carefully", - "highlight", + "associated", "dynamics", + "directly", "trimeric", + "indicate", "structures", - "14", - "positions", - "complexity", - "glu10", - "lys18", - "role", - "facilitate", - "need", - "primarily", + "important", + "among", + "interactions", "impact", "plays", - "molecular", - "directly", - "involving", - "identity", - "associated", - "large", - "subsequent", - "depends", - "bundles", - "extent", - "favorably", - "thermodynamic", + "synergistic", "emphasizing", - "among", "4", - "simulations", - "exquisite", - "engineering", - "bundle", - "donor", - "hydrophobic", - "proximity", - "indicate", - "important", - "stabilization", - "depending", - "nonpolar", - "possibility", - "experiments", - "residues", - "f", - "significant", - "b", - "residue", - "purposes", - "helix", - "hyperstable", - "within", - "relative", - "pair", - "new" + "smaller", + "significant" ], "release_date":"2020-04-29", "publication":"\"Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle\", Biochemistry, 59, 1672-1679", @@ -329832,95 +330958,95 @@ ], "subtitle":"S2 symmetric peptide design number 1, wednesday", "tags":[ - "l and d-amino acids", - "cyclic peptide", "de novo protein", - "centrosymmetric macrocycle" + "l and d-amino acids", + "centrosymmetric macrocycle", + "cyclic peptide" ], "keywords":[ - "work", - "change", - "metal", - "peptide", - "designed", - "macrocycle", - "improper", - "provide", - "crystal", - "generally", - "extremely", - "based", - "macrocycles", - "switchable", - "bind", - "synthetic", - "successive", - "structure", "affinity", - "starting", - "cyclic", - "power", - "symmetries", - "chain", - "proteins", - "models", - "frequent", - "\u00e5", - "feature", - "almost", + "repeats", "demonstrates", - "rigid", - "binders", - "symmetric", - "nature", - "better", - "match", - "structures", - "natural", + "organic", + "single", + "inverted", + "rotational", "three", - "nearly", "free", - "systems", - "exploring", - "rotational", - "frameworks", - "ranging", - "1", - "inaccessible", - "mirrored", - "six", - "organic", - "compatible", "points", - "design", + "within", "model", + "protein", + "six", + "macrocycles", + "mirrored", + "rare", + "match", + "systems", + "power", "applications", - "symmetry", - "describe", - "promising", - "high", - "sequence", - "repeats", + "crystal", + "creating", + "conformational", + "metal", + "switchable", + "nearly", + "creation", + "starting", + "almost", + "rigid", + "cyclic", + "frameworks", + "bind", + "extremely", + "exploring", + "proteins", + "generally", "segment", - "diverse", - "consisting", - "rare", + "inaccessible", + "found", + "computational", + "1", + "peptide", "values", - "conformational", - "single", "zinc", - "reveal", - "found", - "inverted", - "creating", - "creation", - "protein", - "identical", + "symmetry", + "design", + "chain", + "diverse", + "binders", + "work", + "improper", + "feature", + "natural", + "consisting", + "successive", + "symmetric", "backbone", - "within", - "computational", + "promising", + "sequence", + "identical", + "describe", + "reveal", + "designed", + "rmsd", + "models", + "structures", + "ranging", + "based", + "symmetries", + "\u00e5", + "structure", + "synthetic", + "provide", + "nature", + "frequent", + "compatible", + "macrocycle", "internal", - "rmsd" + "change", + "high", + "better" ], "release_date":"2020-09-23", "publication":"\"Computational design of mixed chirality peptide macrocycles with internal symmetry\", Protein Sci., 29, 2433-2445", @@ -330051,95 +331177,95 @@ ], "subtitle":"S2 symmetric peptide design number 2, morticia", "tags":[ - "l and d-amino acids", - "cyclic peptide", "de novo protein", - "centrosymmetric macrocycle" + "l and d-amino acids", + "centrosymmetric macrocycle", + "cyclic peptide" ], "keywords":[ - "work", - "change", - "metal", - "peptide", - "designed", - "macrocycle", - "improper", - "provide", - "crystal", - "generally", - "extremely", - "based", - "macrocycles", - "switchable", - "bind", - "synthetic", - "successive", - "structure", "affinity", - "starting", - "cyclic", - "power", - "symmetries", - "chain", - "proteins", - "models", - "frequent", - "\u00e5", - "feature", - "almost", + "repeats", "demonstrates", - "rigid", - "binders", - "symmetric", - "nature", - "better", - "match", - "structures", - "natural", + "organic", + "single", + "inverted", + "rotational", "three", - "nearly", "free", - "systems", - "exploring", - "rotational", - "frameworks", - "ranging", - "1", - "inaccessible", - "mirrored", - "six", - "organic", - "compatible", "points", - "design", + "within", "model", + "protein", + "six", + "macrocycles", + "mirrored", + "rare", + "match", + "systems", + "power", "applications", - "symmetry", - "describe", - "promising", - "high", - "sequence", - "repeats", + "crystal", + "creating", + "conformational", + "metal", + "switchable", + "nearly", + "creation", + "starting", + "almost", + "rigid", + "cyclic", + "frameworks", + "bind", + "extremely", + "exploring", + "proteins", + "generally", "segment", - "diverse", - "consisting", - "rare", + "inaccessible", + "found", + "computational", + "1", + "peptide", "values", - "conformational", - "single", "zinc", - "reveal", - "found", - "inverted", - "creating", - "creation", - "protein", - "identical", + "symmetry", + "design", + "chain", + "diverse", + "binders", + "work", + "improper", + "feature", + "natural", + "consisting", + "successive", + "symmetric", "backbone", - "within", - "computational", + "promising", + "sequence", + "identical", + "describe", + "reveal", + "designed", + "rmsd", + "models", + "structures", + "ranging", + "based", + "symmetries", + "\u00e5", + "structure", + "synthetic", + "provide", + "nature", + "frequent", + "compatible", + "macrocycle", "internal", - "rmsd" + "change", + "high", + "better" ], "release_date":"2020-09-23", "publication":"\"Computational design of mixed chirality peptide macrocycles with internal symmetry\", Protein Sci., 29, 2433-2445", @@ -330270,95 +331396,95 @@ ], "subtitle":"S2 symmetric peptide design number 3 crystal form 1, lurch", "tags":[ - "l and d-amino acids", - "cyclic peptide", "de novo protein", - "centrosymmetric macrocycle" + "l and d-amino acids", + "centrosymmetric macrocycle", + "cyclic peptide" ], "keywords":[ - "work", - "change", - "metal", - "peptide", - "designed", - "macrocycle", - "improper", - "provide", - "crystal", - "generally", - "extremely", - "based", - "macrocycles", - "switchable", - "bind", - "synthetic", - "successive", - "structure", "affinity", - "starting", - "cyclic", - "power", - "symmetries", - "chain", - "proteins", - "models", - "frequent", - "\u00e5", - "feature", - "almost", + "repeats", "demonstrates", - "rigid", - "binders", - "symmetric", - "nature", - "better", - "match", - "structures", - "natural", + "organic", + "single", + "inverted", + "rotational", "three", - "nearly", "free", - "systems", - "exploring", - "rotational", - "frameworks", - "ranging", - "1", - "inaccessible", - "mirrored", - "six", - "organic", - "compatible", "points", - "design", + "within", "model", + "protein", + "six", + "macrocycles", + "mirrored", + "rare", + "match", + "systems", + "power", "applications", - "symmetry", - "describe", - "promising", - "high", - "sequence", - "repeats", + "crystal", + "creating", + "conformational", + "metal", + "switchable", + "nearly", + "creation", + "starting", + "almost", + "rigid", + "cyclic", + "frameworks", + "bind", + "extremely", + "exploring", + "proteins", + "generally", "segment", - "diverse", - "consisting", - "rare", + "inaccessible", + "found", + "computational", + "1", + "peptide", "values", - "conformational", - "single", "zinc", - "reveal", - "found", - "inverted", - "creating", - "creation", - "protein", - "identical", + "symmetry", + "design", + "chain", + "diverse", + "binders", + "work", + "improper", + "feature", + "natural", + "consisting", + "successive", + "symmetric", "backbone", - "within", - "computational", + "promising", + "sequence", + "identical", + "describe", + "reveal", + "designed", + "rmsd", + "models", + "structures", + "ranging", + "based", + "symmetries", + "\u00e5", + "structure", + "synthetic", + "provide", + "nature", + "frequent", + "compatible", + "macrocycle", "internal", - "rmsd" + "change", + "high", + "better" ], "release_date":"2020-09-23", "publication":"\"Computational design of mixed chirality peptide macrocycles with internal symmetry\", Protein Sci., 29, 2433-2445", @@ -330489,95 +331615,95 @@ ], "subtitle":"S2 symmetric peptide design number 3 crystal form 2, lurch", "tags":[ - "l and d-amino acids", - "cyclic peptide", "de novo protein", - "centrosymmetric macrocycle" + "l and d-amino acids", + "centrosymmetric macrocycle", + "cyclic peptide" ], "keywords":[ - "work", - "change", - "metal", - "peptide", - "designed", - "macrocycle", - "improper", - "provide", - "crystal", - "generally", - "extremely", - "based", - "macrocycles", - "switchable", - "bind", - "synthetic", - "successive", - "structure", "affinity", - "starting", - "cyclic", - "power", - "symmetries", - "chain", - "proteins", - "models", - "frequent", - "\u00e5", - "feature", - "almost", + "repeats", "demonstrates", - "rigid", - "binders", - "symmetric", - "nature", - "better", - "match", - "structures", - "natural", + "organic", + "single", + "inverted", + "rotational", "three", - "nearly", "free", - "systems", - "exploring", - "rotational", - "frameworks", - "ranging", - "1", - "inaccessible", - "mirrored", - "six", - "organic", - "compatible", "points", - "design", + "within", "model", + "protein", + "six", + "macrocycles", + "mirrored", + "rare", + "match", + "systems", + "power", "applications", - "symmetry", - "describe", - "promising", - "high", - "sequence", - "repeats", + "crystal", + "creating", + "conformational", + "metal", + "switchable", + "nearly", + "creation", + "starting", + "almost", + "rigid", + "cyclic", + "frameworks", + "bind", + "extremely", + "exploring", + "proteins", + "generally", "segment", - "diverse", - "consisting", - "rare", + "inaccessible", + "found", + "computational", + "1", + "peptide", "values", - "conformational", - "single", "zinc", - "reveal", - "found", - "inverted", - "creating", - "creation", - "protein", - "identical", + "symmetry", + "design", + "chain", + "diverse", + "binders", + "work", + "improper", + "feature", + "natural", + "consisting", + "successive", + "symmetric", "backbone", - "within", - "computational", + "promising", + "sequence", + "identical", + "describe", + "reveal", + "designed", + "rmsd", + "models", + "structures", + "ranging", + "based", + "symmetries", + "\u00e5", + "structure", + "synthetic", + "provide", + "nature", + "frequent", + "compatible", + "macrocycle", "internal", - "rmsd" + "change", + "high", + "better" ], "release_date":"2020-09-23", "publication":"\"Computational design of mixed chirality peptide macrocycles with internal symmetry\", Protein Sci., 29, 2433-2445", @@ -330708,95 +331834,95 @@ ], "subtitle":"S2 symmetric peptide design number 4 crystal form 1, pugsley", "tags":[ - "l and d-amino acids", - "cyclic peptide", "de novo protein", - "centrosymmetric macrocycle" + "l and d-amino acids", + "centrosymmetric macrocycle", + "cyclic peptide" ], "keywords":[ - "work", - "change", - "metal", - "peptide", - "designed", - "macrocycle", - "improper", - "provide", - "crystal", - "generally", - "extremely", - "based", - "macrocycles", - "switchable", - "bind", - "synthetic", - "successive", - "structure", "affinity", - "starting", - "cyclic", - "power", - "symmetries", - "chain", - "proteins", - "models", - "frequent", - "\u00e5", - "feature", - "almost", + "repeats", "demonstrates", - "rigid", - "binders", - "symmetric", - "nature", - "better", - "match", - "structures", - "natural", + "organic", + "single", + "inverted", + "rotational", "three", - "nearly", "free", - "systems", - "exploring", - "rotational", - "frameworks", - "ranging", - "1", - "inaccessible", - "mirrored", - "six", - "organic", - "compatible", "points", - "design", + "within", "model", + "protein", + "six", + "macrocycles", + "mirrored", + "rare", + "match", + "systems", + "power", "applications", - "symmetry", - "describe", - "promising", - "high", - "sequence", - "repeats", + "crystal", + "creating", + "conformational", + "metal", + "switchable", + "nearly", + "creation", + "starting", + "almost", + "rigid", + "cyclic", + "frameworks", + "bind", + "extremely", + "exploring", + "proteins", + "generally", "segment", - "diverse", - "consisting", - "rare", + "inaccessible", + "found", + "computational", + "1", + "peptide", "values", - "conformational", - "single", "zinc", - "reveal", - "found", - "inverted", - "creating", - "creation", - "protein", - "identical", + "symmetry", + "design", + "chain", + "diverse", + "binders", + "work", + "improper", + "feature", + "natural", + "consisting", + "successive", + "symmetric", "backbone", - "within", - "computational", + "promising", + "sequence", + "identical", + "describe", + "reveal", + "designed", + "rmsd", + "models", + "structures", + "ranging", + "based", + "symmetries", + "\u00e5", + "structure", + "synthetic", + "provide", + "nature", + "frequent", + "compatible", + "macrocycle", "internal", - "rmsd" + "change", + "high", + "better" ], "release_date":"2020-09-23", "publication":"\"Computational design of mixed chirality peptide macrocycles with internal symmetry\", Protein Sci., 29, 2433-2445", @@ -330927,95 +332053,95 @@ ], "subtitle":"S2 symmetric peptide design number 4 crystal form 2, pugsley", "tags":[ - "l and d-amino acids", - "cyclic peptide", "de novo protein", - "centrosymmetric macrocycle" + "l and d-amino acids", + "centrosymmetric macrocycle", + "cyclic peptide" ], "keywords":[ - "work", - "change", - "metal", - "peptide", - "designed", - "macrocycle", - "improper", - "provide", - "crystal", - "generally", - "extremely", - "based", - "macrocycles", - "switchable", - "bind", - "synthetic", - "successive", - "structure", "affinity", - "starting", - "cyclic", - "power", - "symmetries", - "chain", - "proteins", - "models", - "frequent", - "\u00e5", - "feature", - "almost", + "repeats", "demonstrates", - "rigid", - "binders", - "symmetric", - "nature", - "better", - "match", - "structures", - "natural", + "organic", + "single", + "inverted", + "rotational", "three", - "nearly", "free", - "systems", - "exploring", - "rotational", - "frameworks", - "ranging", - "1", - "inaccessible", - "mirrored", - "six", - "organic", - "compatible", "points", - "design", + "within", "model", + "protein", + "six", + "macrocycles", + "mirrored", + "rare", + "match", + "systems", + "power", "applications", - "symmetry", - "describe", - "promising", - "high", - "sequence", - "repeats", + "crystal", + "creating", + "conformational", + "metal", + "switchable", + "nearly", + "creation", + "starting", + "almost", + "rigid", + "cyclic", + "frameworks", + "bind", + "extremely", + "exploring", + "proteins", + "generally", "segment", - "diverse", - "consisting", - "rare", + "inaccessible", + "found", + "computational", + "1", + "peptide", "values", - "conformational", - "single", "zinc", - "reveal", - "found", - "inverted", - "creating", - "creation", - "protein", - "identical", + "symmetry", + "design", + "chain", + "diverse", + "binders", + "work", + "improper", + "feature", + "natural", + "consisting", + "successive", + "symmetric", "backbone", - "within", - "computational", + "promising", + "sequence", + "identical", + "describe", + "reveal", + "designed", + "rmsd", + "models", + "structures", + "ranging", + "based", + "symmetries", + "\u00e5", + "structure", + "synthetic", + "provide", + "nature", + "frequent", + "compatible", + "macrocycle", "internal", - "rmsd" + "change", + "high", + "better" ], "release_date":"2020-12-02", "publication":"\"Computational design of mixed chirality peptide macrocycles with internal symmetry\", Protein Sci., 29, 2433-2445", @@ -331146,95 +332272,95 @@ ], "subtitle":"S2 symmetric peptide design number 5, uncle fester", "tags":[ - "l- and d-amino acids", - "cyclic peptide", "de novo protein", - "centrosymmetric macrocycle" + "centrosymmetric macrocycle", + "l- and d-amino acids", + "cyclic peptide" ], "keywords":[ - "work", - "change", - "metal", - "peptide", - "designed", - "macrocycle", - "improper", - "provide", - "crystal", - "generally", - "extremely", - "based", - "macrocycles", - "switchable", - "bind", - "synthetic", - "successive", - "structure", "affinity", - "starting", - "cyclic", - "power", - "symmetries", - "chain", - "proteins", - "models", - "frequent", - "\u00e5", - "feature", - "almost", + "repeats", "demonstrates", - "rigid", - "binders", - "symmetric", - "nature", - "better", - "match", - "structures", - "natural", + "organic", + "single", + "inverted", + "rotational", "three", - "nearly", "free", - "systems", - "exploring", - "rotational", - "frameworks", - "ranging", - "1", - "inaccessible", - "mirrored", - "six", - "organic", - "compatible", "points", - "design", + "within", "model", + "protein", + "six", + "macrocycles", + "mirrored", + "rare", + "match", + "systems", + "power", "applications", - "symmetry", - "describe", - "promising", - "high", - "sequence", - "repeats", + "crystal", + "creating", + "conformational", + "metal", + "switchable", + "nearly", + "creation", + "starting", + "almost", + "rigid", + "cyclic", + "frameworks", + "bind", + "extremely", + "exploring", + "proteins", + "generally", "segment", - "diverse", - "consisting", - "rare", + "inaccessible", + "found", + "computational", + "1", + "peptide", "values", - "conformational", - "single", "zinc", - "reveal", - "found", - "inverted", - "creating", - "creation", - "protein", - "identical", + "symmetry", + "design", + "chain", + "diverse", + "binders", + "work", + "improper", + "feature", + "natural", + "consisting", + "successive", + "symmetric", "backbone", - "within", - "computational", + "promising", + "sequence", + "identical", + "describe", + "reveal", + "designed", + "rmsd", + "models", + "structures", + "ranging", + "based", + "symmetries", + "\u00e5", + "structure", + "synthetic", + "provide", + "nature", + "frequent", + "compatible", + "macrocycle", "internal", - "rmsd" + "change", + "high", + "better" ], "release_date":"2020-12-02", "publication":"\"Computational design of mixed chirality peptide macrocycles with internal symmetry\", Protein Sci., 29, 2433-2445", @@ -331365,95 +332491,95 @@ ], "subtitle":"S2 symmetric peptide design number 6, london bridge", "tags":[ - "l- and d-amino acids", - "cyclic peptide", "de novo protein", - "centrosymmetric macrocycle" + "centrosymmetric macrocycle", + "l- and d-amino acids", + "cyclic peptide" ], "keywords":[ - "work", - "change", - "metal", - "peptide", - "designed", - "macrocycle", - "improper", - "provide", - "crystal", - "generally", - "extremely", - "based", - "macrocycles", - "switchable", - "bind", - "synthetic", - "successive", - "structure", "affinity", - "starting", - "cyclic", - "power", - "symmetries", - "chain", - "proteins", - "models", - "frequent", - "\u00e5", - "feature", - "almost", + "repeats", "demonstrates", - "rigid", - "binders", - "symmetric", - "nature", - "better", - "match", - "structures", - "natural", + "organic", + "single", + "inverted", + "rotational", "three", - "nearly", "free", - "systems", - "exploring", - "rotational", - "frameworks", - "ranging", - "1", - "inaccessible", - "mirrored", - "six", - "organic", - "compatible", "points", - "design", + "within", "model", + "protein", + "six", + "macrocycles", + "mirrored", + "rare", + "match", + "systems", + "power", "applications", - "symmetry", - "describe", - "promising", - "high", - "sequence", - "repeats", + "crystal", + "creating", + "conformational", + "metal", + "switchable", + "nearly", + "creation", + "starting", + "almost", + "rigid", + "cyclic", + "frameworks", + "bind", + "extremely", + "exploring", + "proteins", + "generally", "segment", - "diverse", - "consisting", - "rare", + "inaccessible", + "found", + "computational", + "1", + "peptide", "values", - "conformational", - "single", "zinc", - "reveal", - "found", - "inverted", - "creating", - "creation", - "protein", - "identical", + "symmetry", + "design", + "chain", + "diverse", + "binders", + "work", + "improper", + "feature", + "natural", + "consisting", + "successive", + "symmetric", "backbone", - "within", - "computational", + "promising", + "sequence", + "identical", + "describe", + "reveal", + "designed", + "rmsd", + "models", + "structures", + "ranging", + "based", + "symmetries", + "\u00e5", + "structure", + "synthetic", + "provide", + "nature", + "frequent", + "compatible", + "macrocycle", "internal", - "rmsd" + "change", + "high", + "better" ], "release_date":"2020-12-02", "publication":"\"Computational design of mixed chirality peptide macrocycles with internal symmetry\", Protein Sci., 29, 2433-2445", @@ -331584,95 +332710,95 @@ ], "subtitle":"S4 symmetric peptide design number 1, tim apo form", "tags":[ - "l- and d-amino acids", - "cyclic peptide", "de novo protein", - "centrosymmetric macrocycle" + "centrosymmetric macrocycle", + "l- and d-amino acids", + "cyclic peptide" ], "keywords":[ - "work", - "change", - "metal", - "peptide", - "designed", - "macrocycle", - "improper", - "provide", - "crystal", - "generally", - "extremely", - "based", - "macrocycles", - "switchable", - "bind", - "synthetic", - "successive", - "structure", "affinity", - "starting", - "cyclic", - "power", - "symmetries", - "chain", - "proteins", - "models", - "frequent", - "\u00e5", - "feature", - "almost", + "repeats", "demonstrates", - "rigid", - "binders", - "symmetric", - "nature", - "better", - "match", - "structures", - "natural", + "organic", + "single", + "inverted", + "rotational", "three", - "nearly", "free", - "systems", - "exploring", - "rotational", - "frameworks", - "ranging", - "1", - "inaccessible", - "mirrored", - "six", - "organic", - "compatible", "points", - "design", + "within", "model", + "protein", + "six", + "macrocycles", + "mirrored", + "rare", + "match", + "systems", + "power", "applications", - "symmetry", - "describe", - "promising", - "high", - "sequence", - "repeats", + "crystal", + "creating", + "conformational", + "metal", + "switchable", + "nearly", + "creation", + "starting", + "almost", + "rigid", + "cyclic", + "frameworks", + "bind", + "extremely", + "exploring", + "proteins", + "generally", "segment", - "diverse", - "consisting", - "rare", + "inaccessible", + "found", + "computational", + "1", + "peptide", "values", - "conformational", - "single", "zinc", - "reveal", - "found", - "inverted", - "creating", - "creation", - "protein", - "identical", + "symmetry", + "design", + "chain", + "diverse", + "binders", + "work", + "improper", + "feature", + "natural", + "consisting", + "successive", + "symmetric", "backbone", - "within", - "computational", + "promising", + "sequence", + "identical", + "describe", + "reveal", + "designed", + "rmsd", + "models", + "structures", + "ranging", + "based", + "symmetries", + "\u00e5", + "structure", + "synthetic", + "provide", + "nature", + "frequent", + "compatible", + "macrocycle", "internal", - "rmsd" + "change", + "high", + "better" ], "release_date":"2020-12-02", "publication":"\"Computational design of mixed chirality peptide macrocycles with internal symmetry\", Protein Sci., 29, 2433-2445", @@ -331803,95 +332929,95 @@ ], "subtitle":"S4 symmetric peptide design number 1, tim zinc-bound form", "tags":[ - "l and d-amino acids", - "cyclic peptide", "de novo protein", - "centrosymmetric macrocycle" + "l and d-amino acids", + "centrosymmetric macrocycle", + "cyclic peptide" ], "keywords":[ - "work", - "change", - "metal", - "peptide", - "designed", - "macrocycle", - "improper", - "provide", - "crystal", - "generally", - "extremely", - "based", - "macrocycles", - "switchable", - "bind", - "synthetic", - "successive", - "structure", "affinity", - "starting", - "cyclic", - "power", - "symmetries", - "chain", - "proteins", - "models", - "frequent", - "\u00e5", - "feature", - "almost", + "repeats", "demonstrates", - "rigid", - "binders", - "symmetric", - "nature", - "better", - "match", - "structures", - "natural", + "organic", + "single", + "inverted", + "rotational", "three", - "nearly", "free", - "systems", - "exploring", - "rotational", - "frameworks", - "ranging", - "1", - "inaccessible", - "mirrored", - "six", - "organic", - "compatible", "points", - "design", + "within", "model", + "protein", + "six", + "macrocycles", + "mirrored", + "rare", + "match", + "systems", + "power", "applications", - "symmetry", - "describe", - "promising", - "high", - "sequence", - "repeats", + "crystal", + "creating", + "conformational", + "metal", + "switchable", + "nearly", + "creation", + "starting", + "almost", + "rigid", + "cyclic", + "frameworks", + "bind", + "extremely", + "exploring", + "proteins", + "generally", "segment", - "diverse", - "consisting", - "rare", + "inaccessible", + "found", + "computational", + "1", + "peptide", "values", - "conformational", - "single", "zinc", - "reveal", - "found", - "inverted", - "creating", - "creation", - "protein", - "identical", + "symmetry", + "design", + "chain", + "diverse", + "binders", + "work", + "improper", + "feature", + "natural", + "consisting", + "successive", + "symmetric", "backbone", - "within", - "computational", + "promising", + "sequence", + "identical", + "describe", + "reveal", + "designed", + "rmsd", + "models", + "structures", + "ranging", + "based", + "symmetries", + "\u00e5", + "structure", + "synthetic", + "provide", + "nature", + "frequent", + "compatible", + "macrocycle", "internal", - "rmsd" + "change", + "high", + "better" ], "release_date":"2020-12-02", "publication":"\"Computational design of mixed chirality peptide macrocycles with internal symmetry\", Protein Sci., 29, 2433-2445", @@ -332022,95 +333148,95 @@ ], "subtitle":"C2 symmetric peptide design number 1, zappy, crystal form 1", "tags":[ - "l and d-amino acids", - "cyclic peptide", + "2-fold symmetric", "de novo protein", - "2-fold symmetric" + "l and d-amino acids", + "cyclic peptide" ], "keywords":[ - "work", - "change", - "metal", - "peptide", - "designed", - "macrocycle", - "improper", - "provide", - "crystal", - "generally", - "extremely", - "based", - "macrocycles", - "switchable", - "bind", - "synthetic", - "successive", - "structure", "affinity", - "starting", - "cyclic", - "power", - "symmetries", - "chain", - "proteins", - "models", - "frequent", - "\u00e5", - "feature", - "almost", + "repeats", "demonstrates", - "rigid", - "binders", - "symmetric", - "nature", - "better", - "match", - "structures", - "natural", + "organic", + "single", + "inverted", + "rotational", "three", - "nearly", "free", - "systems", - "exploring", - "rotational", - "frameworks", - "ranging", - "1", - "inaccessible", - "mirrored", - "six", - "organic", - "compatible", "points", - "design", + "within", "model", + "protein", + "six", + "macrocycles", + "mirrored", + "rare", + "match", + "systems", + "power", "applications", - "symmetry", - "describe", - "promising", - "high", - "sequence", - "repeats", + "crystal", + "creating", + "conformational", + "metal", + "switchable", + "nearly", + "creation", + "starting", + "almost", + "rigid", + "cyclic", + "frameworks", + "bind", + "extremely", + "exploring", + "proteins", + "generally", "segment", - "diverse", - "consisting", - "rare", + "inaccessible", + "found", + "computational", + "1", + "peptide", "values", - "conformational", - "single", "zinc", - "reveal", - "found", - "inverted", - "creating", - "creation", - "protein", - "identical", + "symmetry", + "design", + "chain", + "diverse", + "binders", + "work", + "improper", + "feature", + "natural", + "consisting", + "successive", + "symmetric", "backbone", - "within", - "computational", + "promising", + "sequence", + "identical", + "describe", + "reveal", + "designed", + "rmsd", + "models", + "structures", + "ranging", + "based", + "symmetries", + "\u00e5", + "structure", + "synthetic", + "provide", + "nature", + "frequent", + "compatible", + "macrocycle", "internal", - "rmsd" + "change", + "high", + "better" ], "release_date":"2020-12-02", "publication":"\"Computational design of mixed chirality peptide macrocycles with internal symmetry\", Protein Sci., 29, 2433-2445", @@ -332241,95 +333367,95 @@ ], "subtitle":"C2 symmetric peptide design number 1, zappy, crystal form 2", "tags":[ - "l and d-amino acids", - "cyclic peptide", + "2-fold symmetric", "de novo protein", - "2-fold symmetric" + "l and d-amino acids", + "cyclic peptide" ], "keywords":[ - "work", - "change", - "metal", - "peptide", - "designed", - "macrocycle", - "improper", - "provide", - "crystal", - "generally", - "extremely", - "based", - "macrocycles", - "switchable", - "bind", - "synthetic", - "successive", - "structure", "affinity", - "starting", - "cyclic", - "power", - "symmetries", - "chain", - "proteins", - "models", - "frequent", - "\u00e5", - "feature", - "almost", + "repeats", "demonstrates", - "rigid", - "binders", - "symmetric", - "nature", - "better", - "match", - "structures", - "natural", + "organic", + "single", + "inverted", + "rotational", "three", - "nearly", "free", - "systems", - "exploring", - "rotational", - "frameworks", - "ranging", - "1", - "inaccessible", - "mirrored", - "six", - "organic", - "compatible", "points", - "design", + "within", "model", + "protein", + "six", + "macrocycles", + "mirrored", + "rare", + "match", + "systems", + "power", "applications", - "symmetry", - "describe", - "promising", - "high", - "sequence", - "repeats", + "crystal", + "creating", + "conformational", + "metal", + "switchable", + "nearly", + "creation", + "starting", + "almost", + "rigid", + "cyclic", + "frameworks", + "bind", + "extremely", + "exploring", + "proteins", + "generally", "segment", - "diverse", - "consisting", - "rare", + "inaccessible", + "found", + "computational", + "1", + "peptide", "values", - "conformational", - "single", "zinc", - "reveal", - "found", - "inverted", - "creating", - "creation", - "protein", - "identical", + "symmetry", + "design", + "chain", + "diverse", + "binders", + "work", + "improper", + "feature", + "natural", + "consisting", + "successive", + "symmetric", "backbone", - "within", - "computational", + "promising", + "sequence", + "identical", + "describe", + "reveal", + "designed", + "rmsd", + "models", + "structures", + "ranging", + "based", + "symmetries", + "\u00e5", + "structure", + "synthetic", + "provide", + "nature", + "frequent", + "compatible", + "macrocycle", "internal", - "rmsd" + "change", + "high", + "better" ], "release_date":"2020-12-02", "publication":"\"Computational design of mixed chirality peptide macrocycles with internal symmetry\", Protein Sci., 29, 2433-2445", @@ -332460,95 +333586,95 @@ ], "subtitle":"C3 symmetric peptide design number 1, sporty, crystal form 1", "tags":[ - "l and d-amino acids", - "cyclic peptide", + "3-fold symmetric", "de novo protein", - "3-fold symmetric" + "l and d-amino acids", + "cyclic peptide" ], "keywords":[ - "work", - "change", - "metal", - "peptide", - "designed", - "macrocycle", - "improper", - "provide", - "crystal", - "generally", - "extremely", - "based", - "macrocycles", - "switchable", - "bind", - "synthetic", - "successive", - "structure", "affinity", - "starting", - "cyclic", - "power", - "symmetries", - "chain", - "proteins", - "models", - "frequent", - "\u00e5", - "feature", - "almost", + "repeats", "demonstrates", - "rigid", - "binders", - "symmetric", - "nature", - "better", - "match", - "structures", - "natural", + "organic", + "single", + "inverted", + "rotational", "three", - "nearly", "free", - "systems", - "exploring", - "rotational", - "frameworks", - "ranging", - "1", - "inaccessible", - "mirrored", - "six", - "organic", - "compatible", "points", - "design", + "within", "model", + "protein", + "six", + "macrocycles", + "mirrored", + "rare", + "match", + "systems", + "power", "applications", - "symmetry", - "describe", - "promising", - "high", - "sequence", - "repeats", + "crystal", + "creating", + "conformational", + "metal", + "switchable", + "nearly", + "creation", + "starting", + "almost", + "rigid", + "cyclic", + "frameworks", + "bind", + "extremely", + "exploring", + "proteins", + "generally", "segment", - "diverse", - "consisting", - "rare", + "inaccessible", + "found", + "computational", + "1", + "peptide", "values", - "conformational", - "single", "zinc", - "reveal", - "found", - "inverted", - "creating", - "creation", - "protein", - "identical", + "symmetry", + "design", + "chain", + "diverse", + "binders", + "work", + "improper", + "feature", + "natural", + "consisting", + "successive", + "symmetric", "backbone", - "within", - "computational", + "promising", + "sequence", + "identical", + "describe", + "reveal", + "designed", + "rmsd", + "models", + "structures", + "ranging", + "based", + "symmetries", + "\u00e5", + "structure", + "synthetic", + "provide", + "nature", + "frequent", + "compatible", + "macrocycle", "internal", - "rmsd" + "change", + "high", + "better" ], "release_date":"2020-12-02", "publication":"\"Computational design of mixed chirality peptide macrocycles with internal symmetry\", Protein Sci., 29, 2433-2445", @@ -332680,95 +333806,95 @@ ], "subtitle":"C3 symmetric peptide design number 1, sporty, crystal form 2", "tags":[ - "l and d-amino acids", - "cyclic peptide", + "3-fold symmetric", "de novo protein", - "3-fold symmetric" + "l and d-amino acids", + "cyclic peptide" ], "keywords":[ - "work", - "change", - "metal", - "peptide", - "designed", - "macrocycle", - "improper", - "provide", - "crystal", - "generally", - "extremely", - "based", - "macrocycles", - "switchable", - "bind", - "synthetic", - "successive", - "structure", "affinity", - "starting", - "cyclic", - "power", - "symmetries", - "chain", - "proteins", - "models", - "frequent", - "\u00e5", - "feature", - "almost", + "repeats", "demonstrates", - "rigid", - "binders", - "symmetric", - "nature", - "better", - "match", - "structures", - "natural", + "organic", + "single", + "inverted", + "rotational", "three", - "nearly", "free", - "systems", - "exploring", - "rotational", - "frameworks", - "ranging", - "1", - "inaccessible", - "mirrored", - "six", - "organic", - "compatible", "points", - "design", + "within", "model", + "protein", + "six", + "macrocycles", + "mirrored", + "rare", + "match", + "systems", + "power", "applications", - "symmetry", - "describe", - "promising", - "high", - "sequence", - "repeats", + "crystal", + "creating", + "conformational", + "metal", + "switchable", + "nearly", + "creation", + "starting", + "almost", + "rigid", + "cyclic", + "frameworks", + "bind", + "extremely", + "exploring", + "proteins", + "generally", "segment", - "diverse", - "consisting", - "rare", + "inaccessible", + "found", + "computational", + "1", + "peptide", "values", - "conformational", - "single", "zinc", - "reveal", - "found", - "inverted", - "creating", - "creation", - "protein", - "identical", + "symmetry", + "design", + "chain", + "diverse", + "binders", + "work", + "improper", + "feature", + "natural", + "consisting", + "successive", + "symmetric", "backbone", - "within", - "computational", + "promising", + "sequence", + "identical", + "describe", + "reveal", + "designed", + "rmsd", + "models", + "structures", + "ranging", + "based", + "symmetries", + "\u00e5", + "structure", + "synthetic", + "provide", + "nature", + "frequent", + "compatible", + "macrocycle", "internal", - "rmsd" + "change", + "high", + "better" ], "release_date":"2020-12-02", "publication":"\"Computational design of mixed chirality peptide macrocycles with internal symmetry\", Protein Sci., 29, 2433-2445", @@ -332900,95 +334026,95 @@ ], "subtitle":"C3 symmetric peptide design number 2, baby basil", "tags":[ - "racemic mixture", - "cyclic peptide", + "3-fold symmetric", "de novo protein", - "3-fold symmetric" + "racemic mixture", + "cyclic peptide" ], "keywords":[ - "work", - "change", - "metal", - "peptide", - "designed", - "macrocycle", - "improper", - "provide", - "crystal", - "generally", - "extremely", - "based", - "macrocycles", - "switchable", - "bind", - "synthetic", - "successive", - "structure", "affinity", - "starting", - "cyclic", - "power", - "symmetries", - "chain", - "proteins", - "models", - "frequent", - "\u00e5", - "feature", - "almost", + "repeats", "demonstrates", - "rigid", - "binders", - "symmetric", - "nature", - "better", - "match", - "structures", - "natural", + "organic", + "single", + "inverted", + "rotational", "three", - "nearly", "free", - "systems", - "exploring", - "rotational", - "frameworks", - "ranging", - "1", - "inaccessible", - "mirrored", - "six", - "organic", - "compatible", "points", - "design", + "within", "model", + "protein", + "six", + "macrocycles", + "mirrored", + "rare", + "match", + "systems", + "power", "applications", - "symmetry", - "describe", - "promising", - "high", - "sequence", - "repeats", + "crystal", + "creating", + "conformational", + "metal", + "switchable", + "nearly", + "creation", + "starting", + "almost", + "rigid", + "cyclic", + "frameworks", + "bind", + "extremely", + "exploring", + "proteins", + "generally", "segment", - "diverse", - "consisting", - "rare", + "inaccessible", + "found", + "computational", + "1", + "peptide", "values", - "conformational", - "single", "zinc", - "reveal", - "found", - "inverted", - "creating", - "creation", - "protein", - "identical", + "symmetry", + "design", + "chain", + "diverse", + "binders", + "work", + "improper", + "feature", + "natural", + "consisting", + "successive", + "symmetric", "backbone", - "within", - "computational", + "promising", + "sequence", + "identical", + "describe", + "reveal", + "designed", + "rmsd", + "models", + "structures", + "ranging", + "based", + "symmetries", + "\u00e5", + "structure", + "synthetic", + "provide", + "nature", + "frequent", + "compatible", + "macrocycle", "internal", - "rmsd" + "change", + "high", + "better" ], "release_date":"2020-12-02", "publication":"\"Computational design of mixed chirality peptide macrocycles with internal symmetry\", Protein Sci., 29, 2433-2445", @@ -333119,95 +334245,95 @@ ], "subtitle":"C3 symmetric peptide design number 3", "tags":[ - "racemic mixture", - "cyclic peptide", + "3-fold symmetric", "de novo protein", - "3-fold symmetric" + "racemic mixture", + "cyclic peptide" ], "keywords":[ - "work", - "change", - "metal", - "peptide", - "designed", - "macrocycle", - "improper", - "provide", - "crystal", - "generally", - "extremely", - "based", - "macrocycles", - "switchable", - "bind", - "synthetic", - "successive", - "structure", "affinity", - "starting", - "cyclic", - "power", - "symmetries", - "chain", - "proteins", - "models", - "frequent", - "\u00e5", - "feature", - "almost", + "repeats", "demonstrates", - "rigid", - "binders", - "symmetric", - "nature", - "better", - "match", - "structures", - "natural", + "organic", + "single", + "inverted", + "rotational", "three", - "nearly", "free", - "systems", - "exploring", - "rotational", - "frameworks", - "ranging", - "1", - "inaccessible", - "mirrored", - "six", - "organic", - "compatible", "points", - "design", + "within", "model", + "protein", + "six", + "macrocycles", + "mirrored", + "rare", + "match", + "systems", + "power", "applications", - "symmetry", - "describe", - "promising", - "high", - "sequence", - "repeats", + "crystal", + "creating", + "conformational", + "metal", + "switchable", + "nearly", + "creation", + "starting", + "almost", + "rigid", + "cyclic", + "frameworks", + "bind", + "extremely", + "exploring", + "proteins", + "generally", "segment", - "diverse", - "consisting", - "rare", + "inaccessible", + "found", + "computational", + "1", + "peptide", "values", - "conformational", - "single", "zinc", - "reveal", - "found", - "inverted", - "creating", - "creation", - "protein", - "identical", + "symmetry", + "design", + "chain", + "diverse", + "binders", + "work", + "improper", + "feature", + "natural", + "consisting", + "successive", + "symmetric", "backbone", - "within", - "computational", + "promising", + "sequence", + "identical", + "describe", + "reveal", + "designed", + "rmsd", + "models", + "structures", + "ranging", + "based", + "symmetries", + "\u00e5", + "structure", + "synthetic", + "provide", + "nature", + "frequent", + "compatible", + "macrocycle", "internal", - "rmsd" + "change", + "high", + "better" ], "release_date":"2020-12-02", "publication":"\"Computational design of mixed chirality peptide macrocycles with internal symmetry\", Protein Sci., 29, 2433-2445", @@ -333294,9 +334420,9 @@ "subtitle":"Solution structure of the cyclic peptide 3.1b", "tags":[ "rapid", + "bromodomain", "inhibitor", "bet", - "bromodomain", "transcription", "cyclic peptide" ], @@ -333419,86 +334545,86 @@ "helix" ], "keywords":[ - "confirm", + "engineering", + "molecular", + "role", + "hydrophobic", + "hyperstable", + "show", + "presence", + "substitutions", + "surprising", + "within", "results", + "new", + "residue", + "lys18", + "positions", + "stabilization", + "pair", + "thermodynamic", + "b", + "exquisite", + "subsequent", + "depends", + "confirm", + "crystal", + "possibility", + "simulations", + "donor", + "favorably", + "bundles", + "consider", + "nearby", + "carefully", "stabilizing", - "possibilities", - "character", - "suggest", - "still", - "substitutions", + "involving", + "purposes", + "relative", + "residues", + "helix", + "primarily", + "depending", "interact", - "smaller", - "nearby", - "crystal", - "show", - "interactions", + "large", + "suggest", + "glu10", + "possibilities", + "extent", + "suggesting", + "facilitate", + "bundle", "c", - "surprising", + "highlight", + "need", + "identity", + "proximity", + "still", + "experiments", + "complexity", + "f", + "14", + "nonpolar", + "character", + "lys7", "interaction", - "synergistic", "allows", - "consider", - "suggesting", - "lys7", - "presence", - "carefully", - "highlight", + "associated", "dynamics", + "directly", "trimeric", + "indicate", "structures", - "14", - "positions", - "complexity", - "glu10", - "lys18", - "role", - "facilitate", - "need", - "primarily", + "important", + "among", + "interactions", "impact", "plays", - "molecular", - "directly", - "involving", - "identity", - "associated", - "large", - "subsequent", - "depends", - "bundles", - "extent", - "favorably", - "thermodynamic", + "synergistic", "emphasizing", - "among", "4", - "simulations", - "exquisite", - "engineering", - "bundle", - "donor", - "hydrophobic", - "proximity", - "indicate", - "important", - "stabilization", - "depending", - "nonpolar", - "possibility", - "experiments", - "residues", - "f", - "significant", - "b", - "residue", - "purposes", - "helix", - "hyperstable", - "within", - "relative", - "pair", - "new" + "smaller", + "significant" ], "release_date":"2020-04-29", "publication":"\"Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle\", Biochemistry, 59, 1672-1679", @@ -333713,86 +334839,86 @@ "helix" ], "keywords":[ - "confirm", + "engineering", + "molecular", + "role", + "hydrophobic", + "hyperstable", + "show", + "presence", + "substitutions", + "surprising", + "within", "results", + "new", + "residue", + "lys18", + "positions", + "stabilization", + "pair", + "thermodynamic", + "b", + "exquisite", + "subsequent", + "depends", + "confirm", + "crystal", + "possibility", + "simulations", + "donor", + "favorably", + "bundles", + "consider", + "nearby", + "carefully", "stabilizing", - "possibilities", - "character", - "suggest", - "still", - "substitutions", + "involving", + "purposes", + "relative", + "residues", + "helix", + "primarily", + "depending", "interact", - "smaller", - "nearby", - "crystal", - "show", - "interactions", + "large", + "suggest", + "glu10", + "possibilities", + "extent", + "suggesting", + "facilitate", + "bundle", "c", - "surprising", + "highlight", + "need", + "identity", + "proximity", + "still", + "experiments", + "complexity", + "f", + "14", + "nonpolar", + "character", + "lys7", "interaction", - "synergistic", "allows", - "consider", - "suggesting", - "lys7", - "presence", - "carefully", - "highlight", + "associated", "dynamics", + "directly", "trimeric", + "indicate", "structures", - "14", - "positions", - "complexity", - "glu10", - "lys18", - "role", - "facilitate", - "need", - "primarily", + "important", + "among", + "interactions", "impact", "plays", - "molecular", - "directly", - "involving", - "identity", - "associated", - "large", - "subsequent", - "depends", - "bundles", - "extent", - "favorably", - "thermodynamic", + "synergistic", "emphasizing", - "among", "4", - "simulations", - "exquisite", - "engineering", - "bundle", - "donor", - "hydrophobic", - "proximity", - "indicate", - "important", - "stabilization", - "depending", - "nonpolar", - "possibility", - "experiments", - "residues", - "f", - "significant", - "b", - "residue", - "purposes", - "helix", - "hyperstable", - "within", - "relative", - "pair", - "new" + "smaller", + "significant" ], "release_date":"2020-04-29", "publication":"\"Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle\", Biochemistry, 59, 1672-1679", @@ -333979,86 +335105,86 @@ "helix" ], "keywords":[ - "confirm", + "engineering", + "molecular", + "role", + "hydrophobic", + "hyperstable", + "show", + "presence", + "substitutions", + "surprising", + "within", "results", + "new", + "residue", + "lys18", + "positions", + "stabilization", + "pair", + "thermodynamic", + "b", + "exquisite", + "subsequent", + "depends", + "confirm", + "crystal", + "possibility", + "simulations", + "donor", + "favorably", + "bundles", + "consider", + "nearby", + "carefully", "stabilizing", - "possibilities", - "character", - "suggest", - "still", - "substitutions", + "involving", + "purposes", + "relative", + "residues", + "helix", + "primarily", + "depending", "interact", - "smaller", - "nearby", - "crystal", - "show", - "interactions", + "large", + "suggest", + "glu10", + "possibilities", + "extent", + "suggesting", + "facilitate", + "bundle", "c", - "surprising", + "highlight", + "need", + "identity", + "proximity", + "still", + "experiments", + "complexity", + "f", + "14", + "nonpolar", + "character", + "lys7", "interaction", - "synergistic", "allows", - "consider", - "suggesting", - "lys7", - "presence", - "carefully", - "highlight", + "associated", "dynamics", + "directly", "trimeric", + "indicate", "structures", - "14", - "positions", - "complexity", - "glu10", - "lys18", - "role", - "facilitate", - "need", - "primarily", + "important", + "among", + "interactions", "impact", "plays", - "molecular", - "directly", - "involving", - "identity", - "associated", - "large", - "subsequent", - "depends", - "bundles", - "extent", - "favorably", - "thermodynamic", + "synergistic", "emphasizing", - "among", "4", - "simulations", - "exquisite", - "engineering", - "bundle", - "donor", - "hydrophobic", - "proximity", - "indicate", - "important", - "stabilization", - "depending", - "nonpolar", - "possibility", - "experiments", - "residues", - "f", - "significant", - "b", - "residue", - "purposes", - "helix", - "hyperstable", - "within", - "relative", - "pair", - "new" + "smaller", + "significant" ], "release_date":"2020-04-29", "publication":"\"Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle\", Biochemistry, 59, 1672-1679", @@ -334225,86 +335351,86 @@ "helix" ], "keywords":[ - "confirm", + "engineering", + "molecular", + "role", + "hydrophobic", + "hyperstable", + "show", + "presence", + "substitutions", + "surprising", + "within", "results", + "new", + "residue", + "lys18", + "positions", + "stabilization", + "pair", + "thermodynamic", + "b", + "exquisite", + "subsequent", + "depends", + "confirm", + "crystal", + "possibility", + "simulations", + "donor", + "favorably", + "bundles", + "consider", + "nearby", + "carefully", "stabilizing", - "possibilities", - "character", - "suggest", - "still", - "substitutions", + "involving", + "purposes", + "relative", + "residues", + "helix", + "primarily", + "depending", "interact", - "smaller", - "nearby", - "crystal", - "show", - "interactions", + "large", + "suggest", + "glu10", + "possibilities", + "extent", + "suggesting", + "facilitate", + "bundle", "c", - "surprising", + "highlight", + "need", + "identity", + "proximity", + "still", + "experiments", + "complexity", + "f", + "14", + "nonpolar", + "character", + "lys7", "interaction", - "synergistic", "allows", - "consider", - "suggesting", - "lys7", - "presence", - "carefully", - "highlight", + "associated", "dynamics", + "directly", "trimeric", + "indicate", "structures", - "14", - "positions", - "complexity", - "glu10", - "lys18", - "role", - "facilitate", - "need", - "primarily", + "important", + "among", + "interactions", "impact", "plays", - "molecular", - "directly", - "involving", - "identity", - "associated", - "large", - "subsequent", - "depends", - "bundles", - "extent", - "favorably", - "thermodynamic", + "synergistic", "emphasizing", - "among", "4", - "simulations", - "exquisite", - "engineering", - "bundle", - "donor", - "hydrophobic", - "proximity", - "indicate", - "important", - "stabilization", - "depending", - "nonpolar", - "possibility", - "experiments", - "residues", - "f", - "significant", - "b", - "residue", - "purposes", - "helix", - "hyperstable", - "within", - "relative", - "pair", - "new" + "smaller", + "significant" ], "release_date":"2020-04-29", "publication":"\"Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle\", Biochemistry, 59, 1672-1679", @@ -334471,86 +335597,86 @@ "helix" ], "keywords":[ - "confirm", + "engineering", + "molecular", + "role", + "hydrophobic", + "hyperstable", + "show", + "presence", + "substitutions", + "surprising", + "within", "results", + "new", + "residue", + "lys18", + "positions", + "stabilization", + "pair", + "thermodynamic", + "b", + "exquisite", + "subsequent", + "depends", + "confirm", + "crystal", + "possibility", + "simulations", + "donor", + "favorably", + "bundles", + "consider", + "nearby", + "carefully", "stabilizing", - "possibilities", - "character", - "suggest", - "still", - "substitutions", + "involving", + "purposes", + "relative", + "residues", + "helix", + "primarily", + "depending", "interact", - "smaller", - "nearby", - "crystal", - "show", - "interactions", + "large", + "suggest", + "glu10", + "possibilities", + "extent", + "suggesting", + "facilitate", + "bundle", "c", - "surprising", + "highlight", + "need", + "identity", + "proximity", + "still", + "experiments", + "complexity", + "f", + "14", + "nonpolar", + "character", + "lys7", "interaction", - "synergistic", "allows", - "consider", - "suggesting", - "lys7", - "presence", - "carefully", - "highlight", + "associated", "dynamics", + "directly", "trimeric", + "indicate", "structures", - "14", - "positions", - "complexity", - "glu10", - "lys18", - "role", - "facilitate", - "need", - "primarily", + "important", + "among", + "interactions", "impact", "plays", - "molecular", - "directly", - "involving", - "identity", - "associated", - "large", - "subsequent", - "depends", - "bundles", - "extent", - "favorably", - "thermodynamic", + "synergistic", "emphasizing", - "among", "4", - "simulations", - "exquisite", - "engineering", - "bundle", - "donor", - "hydrophobic", - "proximity", - "indicate", - "important", - "stabilization", - "depending", - "nonpolar", - "possibility", - "experiments", - "residues", - "f", - "significant", - "b", - "residue", - "purposes", - "helix", - "hyperstable", - "within", - "relative", - "pair", - "new" + "smaller", + "significant" ], "release_date":"2020-04-29", "publication":"\"Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle\", Biochemistry, 59, 1672-1679", @@ -334591,11 +335717,11 @@ }, { "sim":61.0, - "partner":"6v58" + "partner":"6osd" }, { "sim":61.0, - "partner":"6ov9" + "partner":"6v57" }, { "sim":61.0, @@ -334603,15 +335729,15 @@ }, { "sim":61.0, - "partner":"6v57" + "partner":"6q1w" }, { "sim":61.0, - "partner":"6osd" + "partner":"6v58" }, { "sim":61.0, - "partner":"6q1w" + "partner":"6ov9" }, { "sim":60.0, @@ -334619,23 +335745,23 @@ }, { "sim":59.0, - "partner":"6u47" + "partner":"6ovv" }, { "sim":59.0, - "partner":"6ovv" + "partner":"5uxt" }, { "sim":59.0, - "partner":"6q22" + "partner":"6v5j" }, { "sim":59.0, - "partner":"6v5j" + "partner":"6q22" }, { "sim":59.0, - "partner":"5uxt" + "partner":"6u47" }, { "sim":56.0, @@ -334777,86 +335903,86 @@ "helix" ], "keywords":[ - "confirm", + "engineering", + "molecular", + "role", + "hydrophobic", + "hyperstable", + "show", + "presence", + "substitutions", + "surprising", + "within", "results", + "new", + "residue", + "lys18", + "positions", + "stabilization", + "pair", + "thermodynamic", + "b", + "exquisite", + "subsequent", + "depends", + "confirm", + "crystal", + "possibility", + "simulations", + "donor", + "favorably", + "bundles", + "consider", + "nearby", + "carefully", "stabilizing", - "possibilities", - "character", - "suggest", - "still", - "substitutions", + "involving", + "purposes", + "relative", + "residues", + "helix", + "primarily", + "depending", "interact", - "smaller", - "nearby", - "crystal", - "show", - "interactions", + "large", + "suggest", + "glu10", + "possibilities", + "extent", + "suggesting", + "facilitate", + "bundle", "c", - "surprising", + "highlight", + "need", + "identity", + "proximity", + "still", + "experiments", + "complexity", + "f", + "14", + "nonpolar", + "character", + "lys7", "interaction", - "synergistic", "allows", - "consider", - "suggesting", - "lys7", - "presence", - "carefully", - "highlight", + "associated", "dynamics", + "directly", "trimeric", + "indicate", "structures", - "14", - "positions", - "complexity", - "glu10", - "lys18", - "role", - "facilitate", - "need", - "primarily", + "important", + "among", + "interactions", "impact", "plays", - "molecular", - "directly", - "involving", - "identity", - "associated", - "large", - "subsequent", - "depends", - "bundles", - "extent", - "favorably", - "thermodynamic", + "synergistic", "emphasizing", - "among", "4", - "simulations", - "exquisite", - "engineering", - "bundle", - "donor", - "hydrophobic", - "proximity", - "indicate", - "important", - "stabilization", - "depending", - "nonpolar", - "possibility", - "experiments", - "residues", - "f", - "significant", - "b", - "residue", - "purposes", - "helix", - "hyperstable", - "within", - "relative", - "pair", - "new" + "smaller", + "significant" ], "release_date":"2020-04-29", "publication":"\"Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle\", Biochemistry, 59, 1672-1679", @@ -335024,86 +336150,86 @@ "helix" ], "keywords":[ - "confirm", + "engineering", + "molecular", + "role", + "hydrophobic", + "hyperstable", + "show", + "presence", + "substitutions", + "surprising", + "within", "results", + "new", + "residue", + "lys18", + "positions", + "stabilization", + "pair", + "thermodynamic", + "b", + "exquisite", + "subsequent", + "depends", + "confirm", + "crystal", + "possibility", + "simulations", + "donor", + "favorably", + "bundles", + "consider", + "nearby", + "carefully", "stabilizing", - "possibilities", - "character", - "suggest", - "still", - "substitutions", + "involving", + "purposes", + "relative", + "residues", + "helix", + "primarily", + "depending", "interact", - "smaller", - "nearby", - "crystal", - "show", - "interactions", + "large", + "suggest", + "glu10", + "possibilities", + "extent", + "suggesting", + "facilitate", + "bundle", "c", - "surprising", + "highlight", + "need", + "identity", + "proximity", + "still", + "experiments", + "complexity", + "f", + "14", + "nonpolar", + "character", + "lys7", "interaction", - "synergistic", "allows", - "consider", - "suggesting", - "lys7", - "presence", - "carefully", - "highlight", + "associated", "dynamics", + "directly", "trimeric", + "indicate", "structures", - "14", - "positions", - "complexity", - "glu10", - "lys18", - "role", - "facilitate", - "need", - "primarily", + "important", + "among", + "interactions", "impact", "plays", - "molecular", - "directly", - "involving", - "identity", - "associated", - "large", - "subsequent", - "depends", - "bundles", - "extent", - "favorably", - "thermodynamic", + "synergistic", "emphasizing", - "among", "4", - "simulations", - "exquisite", - "engineering", - "bundle", - "donor", - "hydrophobic", - "proximity", - "indicate", - "important", - "stabilization", - "depending", - "nonpolar", - "possibility", - "experiments", - "residues", - "f", - "significant", - "b", - "residue", - "purposes", - "helix", - "hyperstable", - "within", - "relative", - "pair", - "new" + "smaller", + "significant" ], "release_date":"2020-04-29", "publication":"\"Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle\", Biochemistry, 59, 1672-1679", @@ -335282,88 +336408,88 @@ ], "subtitle":"Apo structure of the de novo pd-1 binding miniprotein gr918.2", "tags":[ + "computational design", + "de novo protein", "disulfide miniprotein", - "binder", "pd-1", - "computational design", - "de novo protein" + "binder" ], "keywords":[ - "inhibits", - "prevent", - "k", + "designed", + "treatments", + "trimeric", + "overexpressing", + "murine", + "rmsd", + "disease", + "often", + "shows", + "design", + "delicate", + "hyperstable", + "direction", + "autoimmunity", "destruction", - "evade", + "take", + "unchecked", + "expressed", + "computation", + "computationally", "ligand", - "inflammatory", - "excessive", + "prevent", + "contribute", + "\u00e5", "nm", - "pathway", + "specifically", + "structure", + "could", + "model", + "immune", + "protein", "cell", + "strongly", + "excessive", + "function", "shifted", - "specifically", - "resulted", - "murine", - "delicate", - "binder", - "\u00e5", + "agonist", "response", - "balance", - "computation", - "death", - "expressed", - "human", - "designed", - "strongly", + "diseases", + "binding", "programmed", - "unchecked", - "interface", - "immune", - "small", - "trimerization", - "miniprotein", - "binds", - "folds", - "system", - "apo", - "often", - "crystal", - "result", - "overexpressing", - "direction", - "design", - "model", + "evade", + "resulted", + "death", "experiment", - "trimeric", - "binding", - "protein", - "autoimmunity", - "using", - "advantage", "backbone", - "proliferation", - "autoimmune", + "advantage", "tumor", - "function", - "structure", - "alternatively", - "activated", - "hyperstable", - "either", - "combination", - "computationally", - "could", - "treatments", - "diseases", - "take", - "shows", "cells", + "alternatively", + "pathway", "activation", - "agonist", + "system", + "interface", + "binder", + "apo", + "small", + "result", + "inflammatory", + "activated", + "folds", + "autoimmune", + "balance", + "k", + "crystal", + "proliferation", + "miniprotein", "decrease", - "contribute", - "disease", - "rmsd" + "binds", + "human", + "inhibits", + "using", + "combination", + "either", + "trimerization" ], "release_date":"2020-12-09", "publication":"\"Computational design of a synthetic PD-1 agonist\", Proc.Natl.Acad.Sci.USA, 118", @@ -335548,84 +336674,84 @@ ], "subtitle":"Computationally designed c3-symmetric homotrimer from tpr repeat protein", "tags":[ - "designed nanoparticles", "de novo protein", + "designed nanoparticles", "designed trimers", "ribosome-binding site" ], "keywords":[ - "predicted", - "work", - "prefusion", + "designed", + "geometries", + "c", + "env", + "hemagglutinin", + "demonstrates", "generation", - "demonstrated", - "tailored", - "intact", - "incorporated", - "viral", - "helices", - "multivalent", - "components", - "assessed", - "geometry", - "presented", + "characterized", "glycoprotein", - "de", - "novo", - "antigen", - "configurations", - "antibody", - "featuring", - "nanoparticles", - "ectodomains", + "prefusion", "elicitation", - "hiv", - "characterized", - "experiments", "way", - "substantially", - "response", "presentation", - "designed", - "enable", - "trimers", - "geometries", - "influenza", + "geometry", "glycoproteins", - "electron", - "antigenically", - "influence", - "immune", - "vaccination", - "demonstrates", - "icosahedral", - "f", - "experimentally", + "tailored", + "fusion", + "influenza", "rsv", - "ability", - "systematic", + "assessed", + "de", + "ectodomains", + "nanoparticles", + "work", "provides", - "match", + "vaccines", + "first", + "experimentally", + "influence", + "configurations", + "intact", + "featuring", + "antigen", "positioned", - "env", + "trimers", + "new", + "incorporated", + "experiments", + "f", + "adopted", "protein", + "immune", + "hiv", "tetrahedral", + "electron", + "response", + "binding", + "vaccination", + "viral", + "enable", "microscopy", - "termini", + "multivalent", + "ability", + "presented", + "novo", + "systematic", + "increase", + "predicted", + "octahedral", + "match", + "demonstrated", + "substantially", + "components", "present", + "helices", + "termini", + "icosahedral", + "antigenically", "scratch", - "c", - "fusion", - "increase", - "vaccines", - "adopted", + "investigate", "antibodies", - "first", - "octahedral", - "binding", - "hemagglutinin", - "new", - "investigate" + "antibody" ], "release_date":"2020-08-12", "publication":"\"Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens\", Elife, 9", @@ -335686,11 +336812,11 @@ }, { "sim":154.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":154.0, - "partner":"8ump" + "partner":"8umr" } ], "seq_thr_sim_natural":[ @@ -335713,29 +336839,29 @@ "sim":0.9688000083, "partner":"2hyz" }, - { - "sim":0.9559999704, - "partner":"8cqq" - }, - { - "sim":0.9607999921, - "partner":"8cqp" - }, { "sim":0.9789999723, "partner":"8ump" }, - { - "sim":0.9509999752, - "partner":"8cig" - }, { "sim":0.9585999846, "partner":"8bu0" }, + { + "sim":0.9607999921, + "partner":"8cqp" + }, { "sim":0.954400003, "partner":"8chy" + }, + { + "sim":0.9559999704, + "partner":"8cqq" + }, + { + "sim":0.9509999752, + "partner":"8cig" } ], "struct_thr_sim_natural":[ @@ -335885,83 +337011,83 @@ ], "subtitle":"Computationally designed c3-symmetric homotrimer from heat repeat protein", "tags":[ - "vaccine", + "designed protein", "de novo protein", - "designed protein" + "vaccine" ], "keywords":[ - "predicted", - "work", - "prefusion", + "designed", + "geometries", + "c", + "env", + "hemagglutinin", + "demonstrates", "generation", - "demonstrated", - "tailored", - "intact", - "incorporated", - "viral", - "helices", - "multivalent", - "components", - "assessed", - "geometry", - "presented", + "characterized", "glycoprotein", - "de", - "novo", - "antigen", - "configurations", - "antibody", - "featuring", - "nanoparticles", - "ectodomains", + "prefusion", "elicitation", - "hiv", - "characterized", - "experiments", "way", - "substantially", - "response", "presentation", - "designed", - "enable", - "trimers", - "geometries", - "influenza", + "geometry", "glycoproteins", - "electron", - "antigenically", - "influence", - "immune", - "vaccination", - "demonstrates", - "icosahedral", - "f", - "experimentally", + "tailored", + "fusion", + "influenza", "rsv", - "ability", - "systematic", + "assessed", + "de", + "ectodomains", + "nanoparticles", + "work", "provides", - "match", + "vaccines", + "first", + "experimentally", + "influence", + "configurations", + "intact", + "featuring", + "antigen", "positioned", - "env", + "trimers", + "new", + "incorporated", + "experiments", + "f", + "adopted", "protein", + "immune", + "hiv", "tetrahedral", + "electron", + "response", + "binding", + "vaccination", + "viral", + "enable", "microscopy", - "termini", + "multivalent", + "ability", + "presented", + "novo", + "systematic", + "increase", + "predicted", + "octahedral", + "match", + "demonstrated", + "substantially", + "components", "present", + "helices", + "termini", + "icosahedral", + "antigenically", "scratch", - "c", - "fusion", - "increase", - "vaccines", - "adopted", + "investigate", "antibodies", - "first", - "octahedral", - "binding", - "hemagglutinin", - "new", - "investigate" + "antibody" ], "release_date":"2020-08-05", "publication":"\"Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens\", Elife, 9", @@ -336006,11 +337132,11 @@ }, { "sim":254.0, - "partner":"4zv6" + "partner":"6bzx" }, { "sim":254.0, - "partner":"6bzx" + "partner":"4zv6" }, { "sim":178.0, @@ -336249,78 +337375,78 @@ "nanoparticle" ], "keywords":[ - "predicted", - "work", - "prefusion", + "designed", + "geometries", + "c", + "env", + "hemagglutinin", + "demonstrates", "generation", - "demonstrated", - "tailored", - "intact", - "incorporated", - "viral", - "helices", - "multivalent", - "components", - "assessed", - "geometry", - "presented", + "characterized", "glycoprotein", - "de", - "novo", - "antigen", - "configurations", - "antibody", - "featuring", - "nanoparticles", - "ectodomains", + "prefusion", "elicitation", - "hiv", - "characterized", - "experiments", "way", - "substantially", - "response", "presentation", - "designed", - "enable", - "trimers", - "geometries", - "influenza", + "geometry", "glycoproteins", - "electron", - "antigenically", - "influence", - "immune", - "vaccination", - "demonstrates", - "icosahedral", - "f", - "experimentally", + "tailored", + "fusion", + "influenza", "rsv", - "ability", - "systematic", + "assessed", + "de", + "ectodomains", + "nanoparticles", + "work", "provides", - "match", + "vaccines", + "first", + "experimentally", + "influence", + "configurations", + "intact", + "featuring", + "antigen", "positioned", - "env", + "trimers", + "new", + "incorporated", + "experiments", + "f", + "adopted", "protein", + "immune", + "hiv", "tetrahedral", + "electron", + "response", + "binding", + "vaccination", + "viral", + "enable", "microscopy", - "termini", + "multivalent", + "ability", + "presented", + "novo", + "systematic", + "increase", + "predicted", + "octahedral", + "match", + "demonstrated", + "substantially", + "components", "present", + "helices", + "termini", + "icosahedral", + "antigenically", "scratch", - "c", - "fusion", - "increase", - "vaccines", - "adopted", + "investigate", "antibodies", - "first", - "octahedral", - "binding", - "hemagglutinin", - "new", - "investigate" + "antibody" ], "release_date":"2020-08-12", "publication":"\"Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens\", Elife, 9", @@ -336355,6 +337481,10 @@ "sim":497.0, "partner":"6vfk" }, + { + "sim":471.0, + "partner":"5k7v" + }, { "sim":230.0, "partner":"6v8e" @@ -336379,17 +337509,13 @@ "sim":172.0, "partner":"8fwd" }, - { - "sim":146.0, - "partner":"8umr" - }, { "sim":146.0, "partner":"8ump" }, { - "sim":471.0, - "partner":"5k7v" + "sim":146.0, + "partner":"8umr" } ], "seq_thr_sim_natural":[ @@ -336581,78 +337707,78 @@ "nanoparticle" ], "keywords":[ - "predicted", - "work", - "prefusion", + "designed", + "geometries", + "c", + "env", + "hemagglutinin", + "demonstrates", "generation", - "demonstrated", - "tailored", - "intact", - "incorporated", - "viral", - "helices", - "multivalent", - "components", - "assessed", - "geometry", - "presented", + "characterized", "glycoprotein", - "de", - "novo", - "antigen", - "configurations", - "antibody", - "featuring", - "nanoparticles", - "ectodomains", + "prefusion", "elicitation", - "hiv", - "characterized", - "experiments", "way", - "substantially", - "response", "presentation", - "designed", - "enable", - "trimers", - "geometries", - "influenza", + "geometry", "glycoproteins", - "electron", - "antigenically", - "influence", - "immune", - "vaccination", - "demonstrates", - "icosahedral", - "f", - "experimentally", + "tailored", + "fusion", + "influenza", "rsv", - "ability", - "systematic", + "assessed", + "de", + "ectodomains", + "nanoparticles", + "work", "provides", - "match", + "vaccines", + "first", + "experimentally", + "influence", + "configurations", + "intact", + "featuring", + "antigen", "positioned", - "env", + "trimers", + "new", + "incorporated", + "experiments", + "f", + "adopted", "protein", + "immune", + "hiv", "tetrahedral", + "electron", + "response", + "binding", + "vaccination", + "viral", + "enable", "microscopy", - "termini", + "multivalent", + "ability", + "presented", + "novo", + "systematic", + "increase", + "predicted", + "octahedral", + "match", + "demonstrated", + "substantially", + "components", "present", + "helices", + "termini", + "icosahedral", + "antigenically", "scratch", - "c", - "fusion", - "increase", - "vaccines", - "adopted", + "investigate", "antibodies", - "first", - "octahedral", - "binding", - "hemagglutinin", - "new", - "investigate" + "antibody" ], "release_date":"2020-08-12", "publication":"\"Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens\", Elife, 9", @@ -336683,6 +337809,22 @@ "previous_design":"6vfh", "next_design":"6vfj", "seq_thr_sim_designed":[ + { + "sim":288.0, + "partner":"5cwb" + }, + { + "sim":261.0, + "partner":"7mwr" + }, + { + "sim":251.0, + "partner":"8cwy" + }, + { + "sim":247.0, + "partner":"8cws" + }, { "sim":226.0, "partner":"6vfh" @@ -336711,29 +337853,13 @@ "sim":178.0, "partner":"8fwd" }, - { - "sim":147.0, - "partner":"8umr" - }, { "sim":147.0, "partner":"8ump" }, { - "sim":288.0, - "partner":"5cwb" - }, - { - "sim":261.0, - "partner":"7mwr" - }, - { - "sim":251.0, - "partner":"8cwy" - }, - { - "sim":247.0, - "partner":"8cws" + "sim":147.0, + "partner":"8umr" } ], "seq_thr_sim_natural":[ @@ -336914,78 +338040,78 @@ "nanoparticle" ], "keywords":[ - "predicted", - "work", - "prefusion", + "designed", + "geometries", + "c", + "env", + "hemagglutinin", + "demonstrates", "generation", - "demonstrated", - "tailored", - "intact", - "incorporated", - "viral", - "helices", - "multivalent", - "components", - "assessed", - "geometry", - "presented", + "characterized", "glycoprotein", - "de", - "novo", - "antigen", - "configurations", - "antibody", - "featuring", - "nanoparticles", - "ectodomains", + "prefusion", "elicitation", - "hiv", - "characterized", - "experiments", "way", - "substantially", - "response", "presentation", - "designed", - "enable", - "trimers", - "geometries", - "influenza", + "geometry", "glycoproteins", - "electron", - "antigenically", - "influence", - "immune", - "vaccination", - "demonstrates", - "icosahedral", - "f", - "experimentally", + "tailored", + "fusion", + "influenza", "rsv", - "ability", - "systematic", + "assessed", + "de", + "ectodomains", + "nanoparticles", + "work", "provides", - "match", + "vaccines", + "first", + "experimentally", + "influence", + "configurations", + "intact", + "featuring", + "antigen", "positioned", - "env", + "trimers", + "new", + "incorporated", + "experiments", + "f", + "adopted", "protein", + "immune", + "hiv", "tetrahedral", + "electron", + "response", + "binding", + "vaccination", + "viral", + "enable", "microscopy", - "termini", + "multivalent", + "ability", + "presented", + "novo", + "systematic", + "increase", + "predicted", + "octahedral", + "match", + "demonstrated", + "substantially", + "components", "present", + "helices", + "termini", + "icosahedral", + "antigenically", "scratch", - "c", - "fusion", - "increase", - "vaccines", - "adopted", + "investigate", "antibodies", - "first", - "octahedral", - "binding", - "hemagglutinin", - "new", - "investigate" + "antibody" ], "release_date":"2020-08-12", "publication":"\"Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens\", Elife, 9", @@ -337046,11 +338172,11 @@ }, { "sim":146.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":146.0, - "partner":"8ump" + "partner":"8umr" } ], "seq_thr_sim_natural":[ @@ -337120,16 +338246,12 @@ }, { "sim":103.0, - "partner":"1nqw" + "partner":"1nqx" }, { "sim":103.0, "partner":"5mpp" }, - { - "sim":103.0, - "partner":"1nqx" - }, { "sim":103.0, "partner":"1hqk" @@ -337142,6 +338264,10 @@ "sim":103.0, "partner":"1nqv" }, + { + "sim":103.0, + "partner":"1nqw" + }, { "sim":101.0, "partner":"1rvv" @@ -337172,35 +338298,35 @@ }, { "sim":75.0, - "partner":"1w19" + "partner":"2c92" }, { "sim":75.0, - "partner":"2c92" + "partner":"2c9d" }, { "sim":75.0, - "partner":"2c9b" + "partner":"2vi5" }, { "sim":75.0, - "partner":"2vi5" + "partner":"2c94" }, { "sim":75.0, - "partner":"2c9d" + "partner":"1w29" }, { "sim":75.0, - "partner":"2c94" + "partner":"2c97" }, { "sim":75.0, - "partner":"1w29" + "partner":"2c9b" }, { "sim":75.0, - "partner":"2c97" + "partner":"1w19" }, { "sim":75.0, @@ -337375,128 +338501,128 @@ "subtitle":"De novo designed tetrahedral nanoparticle t33_dn10 displaying 4 copies of bg505-sosip trimer on the surface", "tags":[ "de novo protein design", + "de novo protein", "rosetta", "nanoparticle", - "de novo protein", "hiv env" ], "keywords":[ - "differing", - "lineages", - "improve", - "initially", - "sosip", - "stabilizing", - "glycoprotein", "trimer", + "structural", + "number", + "possessed", + "apex", + "group", + "immunogen", + "candidates", + "presenting", + "protein", + "successfully", + "conm", "hiv", - "including", + "given", + "binding", + "differing", + "titers", + "rabbits", "test", "induction", - "designed", - "geometries", - "choice", + "two", "envelope", - "mutations", - "apex", - "determined", - "immunization", - "based", - "sequences", - "versatile", - "findings", - "represent", - "computationally", - "intended", - "applied", - "building", - "however", - "novel", - "elicited", - "immunogen", - "strategies", + "lineages", "subtype", - "altogether", - "proteins", - "viral", - "enables", - "neutralizing", + "focused", + "optimal", + "initially", "similar", - "presented", - "nanoparticles", + "choice", + "bg505", "goal", - "number", - "yielded", - "successfully", - "remains", + "improve", + "enables", + "component", + "engineered", "initial", - "trimeric", - "compared", - "bg505", + "however", + "immunogens", + "nanoparticle", + "soluble", + "stabilizing", + "computationally", + "multimerization", + "immunization", + "fused", + "trimers", + "intended", + "maturation", + "altogether", + "tetrahedral", + "proteins", + "capable", + "characterization", + "multivalent", + "consensus", "octahedral", + "four", + "icosahedral", + "computational", + "combination", + "including", + "geometries", + "design", + "glycoprotein", + "compared", + "nanoparticles", + "concepts", + "functional", + "represent", + "ectodomains", + "different", "platform", - "consensus", - "twenty", + "sizes", "properties", - "antigenic", - "possessed", + "slightly", + "elicited", + "immunogenicity", + "viral", + "underlying", + "applied", + "building", "demonstrated", - "functional", - "multivalent", - "antigens", - "group", - "multimerization", - "rabbits", - "detailed", - "antibody", - "presenting", + "neutralizing", + "versatile", + "elevated", + "describe", + "analyses", "screening", - "ectodomains", - "four", - "trimers", - "fused", - "optimal", - "design", - "nanoparticle", - "characterization", + "implementation", + "designed", "env", - "soluble", - "immunogenicity", - "describe", - "underlying", + "trimeric", + "displaying", + "sequences", "serum", - "indicate", - "candidates", - "structural", + "strategies", "one", - "analyses", - "immunogens", - "sizes", + "indicate", "presentation", - "focused", - "implementation", - "engineered", - "different", + "mutations", + "detailed", + "based", + "remains", + "twenty", + "antigens", "copies", - "displaying", - "icosahedral", - "capable", - "two", - "titers", - "protein", - "tetrahedral", - "given", - "animals", - "elevated", - "conm", "block", - "maturation", - "slightly", - "combination", - "computational", - "component", - "binding", - "concepts" + "determined", + "findings", + "yielded", + "presented", + "antigenic", + "sosip", + "animals", + "novel", + "antibody" ], "release_date":"2020-07-22", "publication":"\"Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens\", Plos Pathog., 16, e1008665-e1008665", @@ -337565,11 +338691,11 @@ }, { "sim":146.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":146.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":96.0, @@ -337597,6 +338723,18 @@ "sim":1223.0, "partner":"6p62" }, + { + "sim":1069.0, + "partner":"9axd" + }, + { + "sim":1069.0, + "partner":"9ays" + }, + { + "sim":1069.0, + "partner":"9ay6" + }, { "sim":1048.0, "partner":"6pw6" @@ -337633,22 +338771,6 @@ "sim":981.0, "partner":"6vn0" }, - { - "sim":981.0, - "partner":"6cm3" - }, - { - "sim":981.0, - "partner":"4tvp" - }, - { - "sim":981.0, - "partner":"5t3x" - }, - { - "sim":981.0, - "partner":"5fyl" - }, { "sim":981.0, "partner":"5vj6" @@ -337698,12 +338820,24 @@ "partner":"5viy" }, { - "sim":979.0, - "partner":"6dfg" + "sim":981.0, + "partner":"6cm3" + }, + { + "sim":981.0, + "partner":"4tvp" + }, + { + "sim":981.0, + "partner":"5t3x" + }, + { + "sim":981.0, + "partner":"5fyl" }, { "sim":979.0, - "partner":"6mtj" + "partner":"6dfg" }, { "sim":979.0, @@ -337733,6 +338867,10 @@ "sim":979.0, "partner":"6nnf" }, + { + "sim":979.0, + "partner":"6mtj" + }, { "sim":978.0, "partner":"6udj" @@ -337769,10 +338907,6 @@ "sim":976.0, "partner":"6nf2" }, - { - "sim":975.0, - "partner":"6ozc" - }, { "sim":975.0, "partner":"4nco" @@ -337785,6 +338919,10 @@ "sim":975.0, "partner":"6opa" }, + { + "sim":975.0, + "partner":"6ozc" + }, { "sim":975.0, "partner":"5aco" @@ -337807,19 +338945,19 @@ }, { "sim":972.0, - "partner":"5jsa" + "partner":"6ot1" }, { "sim":972.0, - "partner":"6osy" + "partner":"5js9" }, { "sim":972.0, - "partner":"6ot1" + "partner":"6osy" }, { "sim":972.0, - "partner":"5js9" + "partner":"5jsa" }, { "sim":971.0, @@ -337885,10 +339023,6 @@ "sim":963.0, "partner":"5d9q" }, - { - "sim":963.0, - "partner":"6orn" - }, { "sim":963.0, "partner":"6oro" @@ -337901,6 +339035,10 @@ "sim":963.0, "partner":"6orp" }, + { + "sim":963.0, + "partner":"6orn" + }, { "sim":963.0, "partner":"6mar" @@ -337937,6 +339075,10 @@ "sim":944.0, "partner":"5w6d" }, + { + "sim":932.0, + "partner":"9ayv" + }, { "sim":918.0, "partner":"3jcb" @@ -337953,6 +339095,18 @@ "sim":832.0, "partner":"6u59" }, + { + "sim":831.0, + "partner":"9axi" + }, + { + "sim":831.0, + "partner":"9axk" + }, + { + "sim":831.0, + "partner":"9atz" + }, { "sim":828.0, "partner":"6nc3" @@ -338043,15 +339197,15 @@ }, { "sim":746.0, - "partner":"6vrw" + "partner":"6vzi" }, { "sim":746.0, - "partner":"6vzi" + "partner":"6vtt" }, { "sim":746.0, - "partner":"6vtt" + "partner":"6vrw" }, { "sim":743.0, @@ -338123,11 +339277,11 @@ }, { "sim":579.0, - "partner":"6mg7" + "partner":"5w4l" }, { "sim":579.0, - "partner":"5w4l" + "partner":"6mg7" }, { "sim":578.0, @@ -338233,10 +339387,6 @@ "sim":533.0, "partner":"6ofi" }, - { - "sim":533.0, - "partner":"3tgr" - }, { "sim":533.0, "partner":"3tgs" @@ -338249,6 +339399,10 @@ "sim":533.0, "partner":"4lsv" }, + { + "sim":533.0, + "partner":"3tgr" + }, { "sim":533.0, "partner":"3rjq" @@ -338257,10 +339411,6 @@ "sim":531.0, "partner":"5te7" }, - { - "sim":529.0, - "partner":"4rfo" - }, { "sim":529.0, "partner":"4dko" @@ -338338,20 +339488,8 @@ "partner":"6bck" }, { - "sim":527.0, - "partner":"3se9" - }, - { - "sim":527.0, - "partner":"4ydl" - }, - { - "sim":527.0, - "partner":"4jb9" - }, - { - "sim":527.0, - "partner":"4olx" + "sim":529.0, + "partner":"4rfo" }, { "sim":527.0, @@ -338449,6 +339587,22 @@ "sim":527.0, "partner":"4olw" }, + { + "sim":527.0, + "partner":"3se9" + }, + { + "sim":527.0, + "partner":"4ydl" + }, + { + "sim":527.0, + "partner":"4jb9" + }, + { + "sim":527.0, + "partner":"4olx" + }, { "sim":527.0, "partner":"3u7y" @@ -338511,11 +339665,11 @@ }, { "sim":517.0, - "partner":"4lst" + "partner":"4jan" }, { "sim":517.0, - "partner":"4jan" + "partner":"4lst" }, { "sim":516.0, @@ -338597,14 +339751,6 @@ "sim":474.0, "partner":"2ny1" }, - { - "sim":471.0, - "partner":"1yyl" - }, - { - "sim":471.0, - "partner":"4rqs" - }, { "sim":471.0, "partner":"5a8h" @@ -338623,11 +339769,11 @@ }, { "sim":471.0, - "partner":"1g9n" + "partner":"2i5y" }, { "sim":471.0, - "partner":"2i5y" + "partner":"1g9n" }, { "sim":471.0, @@ -338637,6 +339783,14 @@ "sim":471.0, "partner":"1rzk" }, + { + "sim":471.0, + "partner":"1yyl" + }, + { + "sim":471.0, + "partner":"4rqs" + }, { "sim":471.0, "partner":"2ny3" @@ -338723,11 +339877,11 @@ }, { "sim":153.0, - "partner":"2bf1" + "partner":"3fus" }, { "sim":153.0, - "partner":"3fus" + "partner":"2bf1" }, { "sim":151.0, @@ -338769,10 +339923,6 @@ "sim":111.0, "partner":"3p30" }, - { - "sim":105.0, - "partner":"1qbz" - }, { "sim":105.0, "partner":"2ezo" @@ -338797,6 +339947,10 @@ "sim":105.0, "partner":"1qce" }, + { + "sim":105.0, + "partner":"1qbz" + }, { "sim":99.0, "partner":"3mac" @@ -338961,6 +340115,10 @@ "sim":70.0, "partner":"5vgj" }, + { + "sim":70.0, + "partner":"8zni" + }, { "sim":68.0, "partner":"1ce4" @@ -338983,11 +340141,11 @@ }, { "sim":67.0, - "partner":"5y14" + "partner":"6j5e" }, { "sim":67.0, - "partner":"6j5e" + "partner":"5y14" }, { "sim":67.0, @@ -339087,19 +340245,19 @@ }, { "sim":56.0, - "partner":"3vie" + "partner":"1aik" }, { "sim":56.0, - "partner":"6jqk" + "partner":"2zzo" }, { "sim":56.0, - "partner":"1aik" + "partner":"3vie" }, { "sim":56.0, - "partner":"2zzo" + "partner":"6jqk" }, { "sim":56.0, @@ -339131,55 +340289,55 @@ }, { "sim":53.0, - "partner":"5g05" + "partner":"5lcw" }, { "sim":53.0, - "partner":"4ui9" + "partner":"5a31" }, { "sim":53.0, - "partner":"5l9t" + "partner":"5khu" }, { "sim":53.0, - "partner":"6q6h" + "partner":"4ui9" }, { "sim":53.0, - "partner":"5lcw" + "partner":"5g04" }, { "sim":53.0, - "partner":"5a31" + "partner":"6q6g" }, { "sim":53.0, - "partner":"5khu" + "partner":"5khr" }, { "sim":53.0, - "partner":"5g04" + "partner":"6tm5" }, { "sim":53.0, - "partner":"5khr" + "partner":"6tlj" }, { "sim":53.0, - "partner":"6q6g" + "partner":"5l9u" }, { "sim":53.0, - "partner":"6tm5" + "partner":"6q6h" }, { "sim":53.0, - "partner":"5l9u" + "partner":"5g05" }, { "sim":53.0, - "partner":"6tlj" + "partner":"5l9t" }, { "sim":52.0, @@ -339365,128 +340523,128 @@ "subtitle":"Bg505-sosip model reconstructed by subparticle extraction and refinement from a tetrahedral nanoparticle t33_dn10", "tags":[ "de novo protein design", + "de novo protein", "rosetta", "nanoparticle", - "de novo protein", "hiv env" ], "keywords":[ - "differing", - "lineages", - "improve", - "initially", - "sosip", - "stabilizing", - "glycoprotein", "trimer", + "structural", + "number", + "possessed", + "apex", + "group", + "immunogen", + "candidates", + "presenting", + "protein", + "successfully", + "conm", "hiv", - "including", + "given", + "binding", + "differing", + "titers", + "rabbits", "test", "induction", - "designed", - "geometries", - "choice", + "two", "envelope", - "mutations", - "apex", - "determined", - "immunization", - "based", - "sequences", - "versatile", - "findings", - "represent", - "computationally", - "intended", - "applied", - "building", - "however", - "novel", - "elicited", - "immunogen", - "strategies", + "lineages", "subtype", - "altogether", - "proteins", - "viral", - "enables", - "neutralizing", + "focused", + "optimal", + "initially", "similar", - "presented", - "nanoparticles", + "choice", + "bg505", "goal", - "number", - "yielded", - "successfully", - "remains", + "improve", + "enables", + "component", + "engineered", "initial", - "trimeric", - "compared", - "bg505", + "however", + "immunogens", + "nanoparticle", + "soluble", + "stabilizing", + "computationally", + "multimerization", + "immunization", + "fused", + "trimers", + "intended", + "maturation", + "altogether", + "tetrahedral", + "proteins", + "capable", + "characterization", + "multivalent", + "consensus", "octahedral", + "four", + "icosahedral", + "computational", + "combination", + "including", + "geometries", + "design", + "glycoprotein", + "compared", + "nanoparticles", + "concepts", + "functional", + "represent", + "ectodomains", + "different", "platform", - "consensus", - "twenty", + "sizes", "properties", - "antigenic", - "possessed", + "slightly", + "elicited", + "immunogenicity", + "viral", + "underlying", + "applied", + "building", "demonstrated", - "functional", - "multivalent", - "antigens", - "group", - "multimerization", - "rabbits", - "detailed", - "antibody", - "presenting", + "neutralizing", + "versatile", + "elevated", + "describe", + "analyses", "screening", - "ectodomains", - "four", - "trimers", - "fused", - "optimal", - "design", - "nanoparticle", - "characterization", + "implementation", + "designed", "env", - "soluble", - "immunogenicity", - "describe", - "underlying", + "trimeric", + "displaying", + "sequences", "serum", - "indicate", - "candidates", - "structural", + "strategies", "one", - "analyses", - "immunogens", - "sizes", + "indicate", "presentation", - "focused", - "implementation", - "engineered", - "different", + "mutations", + "detailed", + "based", + "remains", + "twenty", + "antigens", "copies", - "displaying", - "icosahedral", - "capable", - "two", - "titers", - "protein", - "tetrahedral", - "given", - "animals", - "elevated", - "conm", "block", - "maturation", - "slightly", - "combination", - "computational", - "component", - "binding", - "concepts" + "determined", + "findings", + "yielded", + "presented", + "antigenic", + "sosip", + "animals", + "novel", + "antibody" ], "release_date":"2020-07-22", "publication":"\"Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens\", Plos Pathog., 16, e1008665-e1008665", @@ -339517,14 +340675,14 @@ "previous_design":"6vfk", "next_design":"6vg7", "seq_thr_sim_designed":[ - { - "sim":1066.0, - "partner":"6vl5" - }, { "sim":1068.0, "partner":"6vfk" }, + { + "sim":1066.0, + "partner":"6vl5" + }, { "sim":95.0, "partner":"4dzu" @@ -339535,6 +340693,10 @@ } ], "seq_thr_sim_natural":[ + { + "sim":926.0, + "partner":"9ayv" + }, { "sim":945.0, "partner":"6nf5" @@ -339596,56 +340758,44 @@ "partner":"6v0r" }, { - "sim":743.0, - "partner":"6vy2" - }, - { - "sim":730.0, - "partner":"6uda" - }, - { - "sim":967.0, - "partner":"5u1f" + "sim":1062.0, + "partner":"9axd" }, { - "sim":974.0, - "partner":"5t3x" + "sim":1062.0, + "partner":"9ays" }, { - "sim":974.0, - "partner":"5vj6" + "sim":1062.0, + "partner":"9ay6" }, { - "sim":974.0, - "partner":"6mn7" - }, - { - "sim":971.0, - "partner":"6mtj" + "sim":743.0, + "partner":"6vy2" }, { - "sim":974.0, - "partner":"4tvp" + "sim":730.0, + "partner":"6uda" }, { - "sim":966.0, - "partner":"6ot1" + "sim":967.0, + "partner":"5u1f" }, { - "sim":975.0, - "partner":"6ozc" + "sim":1041.0, + "partner":"6pw6" }, { "sim":970.0, "partner":"6u0n" }, { - "sim":971.0, - "partner":"6nm6" + "sim":974.0, + "partner":"6u0l" }, { - "sim":1041.0, - "partner":"6pw6" + "sim":981.0, + "partner":"6vn0" }, { "sim":974.0, @@ -339655,25 +340805,13 @@ "sim":974.0, "partner":"5v8m" }, - { - "sim":974.0, - "partner":"6u0l" - }, - { - "sim":981.0, - "partner":"6vn0" - }, - { - "sim":974.0, - "partner":"5u7m" - }, { "sim":971.0, "partner":"6mu6" }, { "sim":974.0, - "partner":"5aco" + "partner":"5u7m" }, { "sim":962.0, @@ -339691,6 +340829,10 @@ "sim":961.0, "partner":"6w03" }, + { + "sim":974.0, + "partner":"5aco" + }, { "sim":970.0, "partner":"6udj" @@ -339699,6 +340841,10 @@ "sim":971.0, "partner":"6mtn" }, + { + "sim":971.0, + "partner":"6mu7" + }, { "sim":974.0, "partner":"5thr" @@ -339708,12 +340854,12 @@ "partner":"5uty" }, { - "sim":971.0, - "partner":"6mu7" + "sim":970.0, + "partner":"5cez" }, { "sim":970.0, - "partner":"5cez" + "partner":"6nf2" }, { "sim":970.0, @@ -339727,14 +340873,6 @@ "sim":936.0, "partner":"5w6d" }, - { - "sim":970.0, - "partner":"6nf2" - }, - { - "sim":974.0, - "partner":"4zmj" - }, { "sim":970.0, "partner":"6crq" @@ -339747,6 +340885,10 @@ "sim":975.0, "partner":"6opa" }, + { + "sim":974.0, + "partner":"4zmj" + }, { "sim":971.0, "partner":"6mu8" @@ -339759,13 +340901,17 @@ "sim":974.0, "partner":"5v8l" }, + { + "sim":971.0, + "partner":"6nnf" + }, { "sim":974.0, "partner":"5viy" }, { - "sim":971.0, - "partner":"6nnf" + "sim":974.0, + "partner":"6cm3" }, { "sim":968.0, @@ -339773,7 +340919,7 @@ }, { "sim":974.0, - "partner":"6cm3" + "partner":"6mn7" }, { "sim":959.0, @@ -339783,6 +340929,34 @@ "sim":974.0, "partner":"5fyl" }, + { + "sim":974.0, + "partner":"5vj6" + }, + { + "sim":971.0, + "partner":"6mtj" + }, + { + "sim":974.0, + "partner":"5t3x" + }, + { + "sim":966.0, + "partner":"6ot1" + }, + { + "sim":975.0, + "partner":"6ozc" + }, + { + "sim":974.0, + "partner":"4tvp" + }, + { + "sim":971.0, + "partner":"6nm6" + }, { "sim":735.0, "partner":"6um6" @@ -339807,14 +340981,6 @@ "sim":963.0, "partner":"5d9q" }, - { - "sim":734.0, - "partner":"6um5" - }, - { - "sim":968.0, - "partner":"6mph" - }, { "sim":968.0, "partner":"6cde" @@ -339859,6 +341025,14 @@ "sim":974.0, "partner":"5i8h" }, + { + "sim":734.0, + "partner":"6um5" + }, + { + "sim":968.0, + "partner":"6mph" + }, { "sim":963.0, "partner":"6mar" @@ -339887,17 +341061,29 @@ "sim":878.0, "partner":"6ieq" }, + { + "sim":826.0, + "partner":"9atz" + }, + { + "sim":826.0, + "partner":"9axi" + }, + { + "sim":826.0, + "partner":"9axk" + }, { "sim":730.0, "partner":"5fyj" }, { "sim":822.0, - "partner":"6nc2" + "partner":"6nc3" }, { "sim":822.0, - "partner":"6nc3" + "partner":"6nc2" }, { "sim":792.0, @@ -340005,11 +341191,11 @@ }, { "sim":737.0, - "partner":"6vrw" + "partner":"6vtt" }, { "sim":737.0, - "partner":"6vtt" + "partner":"6vrw" }, { "sim":753.0, @@ -340027,10 +341213,6 @@ "sim":119.0, "partner":"3p30" }, - { - "sim":106.0, - "partner":"1qbz" - }, { "sim":106.0, "partner":"2ezo" @@ -340055,6 +341237,10 @@ "sim":106.0, "partner":"1qce" }, + { + "sim":106.0, + "partner":"1qbz" + }, { "sim":102.0, "partner":"3cp1" @@ -340213,11 +341399,11 @@ }, { "sim":67.0, - "partner":"5y14" + "partner":"6j5e" }, { "sim":67.0, - "partner":"6j5e" + "partner":"5y14" }, { "sim":67.0, @@ -340433,11 +341619,11 @@ }, { "sim":577.0, - "partner":"6mg7" + "partner":"5w4l" }, { "sim":577.0, - "partner":"5w4l" + "partner":"6mg7" }, { "sim":576.0, @@ -340539,10 +341725,6 @@ "sim":533.0, "partner":"6ofi" }, - { - "sim":533.0, - "partner":"3tgr" - }, { "sim":533.0, "partner":"3tgs" @@ -340555,6 +341737,10 @@ "sim":533.0, "partner":"4lsv" }, + { + "sim":533.0, + "partner":"3tgr" + }, { "sim":533.0, "partner":"3rjq" @@ -340563,10 +341749,6 @@ "sim":531.0, "partner":"5te7" }, - { - "sim":529.0, - "partner":"4rfo" - }, { "sim":529.0, "partner":"4dko" @@ -340644,20 +341826,8 @@ "partner":"6bck" }, { - "sim":527.0, - "partner":"3se9" - }, - { - "sim":527.0, - "partner":"4ydl" - }, - { - "sim":527.0, - "partner":"4jb9" - }, - { - "sim":527.0, - "partner":"4olx" + "sim":529.0, + "partner":"4rfo" }, { "sim":527.0, @@ -340755,6 +341925,22 @@ "sim":527.0, "partner":"4olw" }, + { + "sim":527.0, + "partner":"3se9" + }, + { + "sim":527.0, + "partner":"4ydl" + }, + { + "sim":527.0, + "partner":"4jb9" + }, + { + "sim":527.0, + "partner":"4olx" + }, { "sim":527.0, "partner":"3u7y" @@ -340817,11 +342003,11 @@ }, { "sim":517.0, - "partner":"4lst" + "partner":"4jan" }, { "sim":517.0, - "partner":"4jan" + "partner":"4lst" }, { "sim":516.0, @@ -340903,14 +342089,6 @@ "sim":474.0, "partner":"2ny1" }, - { - "sim":471.0, - "partner":"1yyl" - }, - { - "sim":471.0, - "partner":"4rqs" - }, { "sim":471.0, "partner":"5a8h" @@ -340929,11 +342107,11 @@ }, { "sim":471.0, - "partner":"1g9n" + "partner":"2i5y" }, { "sim":471.0, - "partner":"2i5y" + "partner":"1g9n" }, { "sim":471.0, @@ -340943,6 +342121,14 @@ "sim":471.0, "partner":"1rzk" }, + { + "sim":471.0, + "partner":"1yyl" + }, + { + "sim":471.0, + "partner":"4rqs" + }, { "sim":471.0, "partner":"2ny3" @@ -341029,11 +342215,11 @@ }, { "sim":153.0, - "partner":"2bf1" + "partner":"3fus" }, { "sim":153.0, - "partner":"3fus" + "partner":"2bf1" }, { "sim":151.0, @@ -341087,6 +342273,10 @@ "sim":70.0, "partner":"5vgj" }, + { + "sim":70.0, + "partner":"8zni" + }, { "sim":68.0, "partner":"1ce4" @@ -341126,8 +342316,8 @@ "partner":"6vfk" }, "seq_max_sim_natural":{ - "sim":1052.0, - "partner":"6p6f" + "sim":1062.0, + "partner":"9axd" }, "struct_max_sim_designed":{ "sim":0.9534999728, @@ -341193,82 +342383,82 @@ ], "subtitle":"De novo designed rossmann fold protein ros2_49223", "tags":[ - "rossmann fold", - "de novo protein" + "de novo protein", + "rossmann fold" ], "keywords":[ + "geometries", + "designed", + "lucs", + "designing", + "offers", + "naturally", + "design", + "sampling", + "space", + "structural", + "17", "diverse", - "designs", - "mimics", + "encompassing", + "structures", + "well", + "expands", + "families", + "experimentally", + "different", "overall", "tested", - "proteins", - "solved", - "greatly", - "combinatorial", - "families", - "also", - "four", - "elements", - "topologies", - "matched", + "16", + "structure", "fold", - "including", - "method", - "designed", - "geometries", - "well", - "may", - "different", - "expands", - "highly", - "encompassing", - "shapes", - "lucs", - "found", - "optimal", - "vary", + "elements", + "novel", + "new", + "also", + "closely", "precisely", - "two", + "functions", + "matched", + "designable", "nature", - "experimentally", - "closely", - "occurring", - "unit", - "ability", + "biophysical", + "topologies", + "vary", + "function", "folded", - "functions", + "known", + "unit", + "proteins", "38", - "design", - "sampling", - "characterization", - "structures", - "naturally", - "precise", - "surpassing", + "customizable", + "mimics", "generates", - "present", - "45", - "offers", - "paradigm", - "space", - "designing", - "structure", - "function", + "characterization", "showed", - "17", - "16", - "distinct", - "computational", - "designable", + "greatly", + "ability", + "may", + "shapes", + "45", + "combinatorial", + "highly", "tunable", - "known", - "novel", - "structural", + "distinct", + "solved", + "found", + "surpassing", + "two", + "present", + "precise", + "four", "create", - "biophysical", - "new", - "customizable" + "optimal", + "method", + "designs", + "computational", + "including", + "paradigm", + "occurring" ], "release_date":"2020-08-19", "publication":"\"Expanding the space of protein geometries by computational design of de novo fold families\", Science, 369, 1132-1136", @@ -341309,11 +342499,11 @@ }, { "sim":95.0, - "partner":"2kpo" + "partner":"2lv8" }, { "sim":95.0, - "partner":"2lv8" + "partner":"2kpo" }, { "sim":53.0, @@ -341333,7 +342523,7 @@ }, { "sim":51.0, - "partner":"8w06" + "partner":"8v09" }, { "sim":51.0, @@ -341345,7 +342535,7 @@ }, { "sim":51.0, - "partner":"8v09" + "partner":"8w06" }, { "sim":50.0, @@ -341353,11 +342543,11 @@ }, { "sim":50.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":50.0, - "partner":"8w08" + "partner":"8v0a" } ], "seq_thr_sim_natural":[ @@ -341441,10 +342631,6 @@ "sim":57.0, "partner":"5caj" }, - { - "sim":57.0, - "partner":"3c1y" - }, { "sim":57.0, "partner":"3c1z" @@ -341469,6 +342655,10 @@ "sim":57.0, "partner":"4yxm" }, + { + "sim":57.0, + "partner":"3c1y" + }, { "sim":57.0, "partner":"6eqz" @@ -341515,15 +342705,15 @@ }, { "sim":56.0, - "partner":"3la7" + "partner":"3la2" }, { "sim":56.0, - "partner":"3la2" + "partner":"3la3" }, { "sim":56.0, - "partner":"3la3" + "partner":"3la7" }, { "sim":56.0, @@ -341751,11 +342941,11 @@ }, { "sim":54.0, - "partner":"5cvo" + "partner":"6nyo" }, { "sim":54.0, - "partner":"6nyo" + "partner":"5cvo" }, { "sim":54.0, @@ -341923,11 +343113,11 @@ }, { "sim":53.0, - "partner":"4oxc" + "partner":"6gjw" }, { "sim":53.0, - "partner":"6gjw" + "partner":"4oxc" }, { "sim":53.0, @@ -341945,10 +343135,6 @@ "sim":53.0, "partner":"4o1h" }, - { - "sim":53.0, - "partner":"5zrk" - }, { "sim":53.0, "partner":"5zrl" @@ -341977,6 +343163,10 @@ "sim":53.0, "partner":"5zri" }, + { + "sim":53.0, + "partner":"5zrk" + }, { "sim":53.0, "partner":"4ely" @@ -342015,7 +343205,7 @@ }, { "sim":53.0, - "partner":"5edd" + "partner":"8p8o" }, { "sim":53.0, @@ -342051,15 +343241,15 @@ }, { "sim":53.0, - "partner":"8p8o" + "partner":"1sm8" }, { "sim":53.0, - "partner":"1sm8" + "partner":"3hza" }, { "sim":53.0, - "partner":"3hza" + "partner":"5edd" }, { "sim":53.0, @@ -342189,14 +343379,6 @@ "sim":53.0, "partner":"5jyp" }, - { - "sim":53.0, - "partner":"4h2w" - }, - { - "sim":53.0, - "partner":"3mey" - }, { "sim":53.0, "partner":"4h2x" @@ -342233,6 +343415,14 @@ "sim":53.0, "partner":"4h2v" }, + { + "sim":53.0, + "partner":"4h2w" + }, + { + "sim":53.0, + "partner":"3mey" + }, { "sim":53.0, "partner":"1mx3" @@ -342279,11 +343469,11 @@ }, { "sim":53.0, - "partner":"3amu" + "partner":"3amt" }, { "sim":53.0, - "partner":"3amt" + "partner":"3amu" }, { "sim":53.0, @@ -342317,14 +343507,6 @@ "sim":53.0, "partner":"2i4o" }, - { - "sim":53.0, - "partner":"6mlh" - }, - { - "sim":53.0, - "partner":"6mlw" - }, { "sim":53.0, "partner":"6nn1" @@ -342351,15 +343533,19 @@ }, { "sim":53.0, - "partner":"5kqt" + "partner":"6mlh" }, { "sim":53.0, - "partner":"5kqu" + "partner":"6mlw" }, { "sim":53.0, - "partner":"2cj9" + "partner":"5kqt" + }, + { + "sim":53.0, + "partner":"5kqu" }, { "sim":53.0, @@ -342373,6 +343559,10 @@ "sim":53.0, "partner":"2cjb" }, + { + "sim":53.0, + "partner":"2cj9" + }, { "sim":53.0, "partner":"3u9s" @@ -342419,11 +343609,11 @@ }, { "sim":52.0, - "partner":"6iva" + "partner":"6iww" }, { "sim":52.0, - "partner":"6iww" + "partner":"6iva" }, { "sim":52.0, @@ -342463,11 +343653,11 @@ }, { "sim":52.0, - "partner":"4gzc" + "partner":"4gzd" }, { "sim":52.0, - "partner":"4gzd" + "partner":"4gzc" }, { "sim":52.0, @@ -342493,10 +343683,6 @@ "sim":52.0, "partner":"6b9l" }, - { - "sim":52.0, - "partner":"5wg9" - }, { "sim":52.0, "partner":"5wap" @@ -342597,6 +343783,10 @@ "sim":52.0, "partner":"5wei" }, + { + "sim":52.0, + "partner":"5wg9" + }, { "sim":52.0, "partner":"6k69" @@ -342607,11 +343797,11 @@ }, { "sim":52.0, - "partner":"1wc6" + "partner":"1wc1" }, { "sim":52.0, - "partner":"1wc1" + "partner":"1wc6" }, { "sim":52.0, @@ -342711,11 +343901,11 @@ }, { "sim":52.0, - "partner":"2f9t" + "partner":"6non" }, { "sim":52.0, - "partner":"6non" + "partner":"2f9t" }, { "sim":52.0, @@ -342743,11 +343933,11 @@ }, { "sim":52.0, - "partner":"6fcn" + "partner":"6fcm" }, { "sim":52.0, - "partner":"6fcm" + "partner":"6fcn" }, { "sim":52.0, @@ -342861,17 +344051,13 @@ "sim":52.0, "partner":"4ckq" }, - { - "sim":52.0, - "partner":"6e9b" - }, { "sim":52.0, "partner":"6e57" }, { "sim":52.0, - "partner":"5z8a" + "partner":"6e9b" }, { "sim":52.0, @@ -342881,6 +344067,10 @@ "sim":52.0, "partner":"5z83" }, + { + "sim":52.0, + "partner":"5z8a" + }, { "sim":52.0, "partner":"4j7c" @@ -343023,15 +344213,15 @@ }, { "sim":51.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":51.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":51.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":51.0, @@ -343055,43 +344245,43 @@ }, { "sim":51.0, - "partner":"3n39" + "partner":"3n3a" }, { "sim":51.0, - "partner":"3n3a" + "partner":"3n3b" }, { "sim":51.0, - "partner":"3n3b" + "partner":"3n39" }, { "sim":51.0, - "partner":"4evc" + "partner":"3ta8" }, { "sim":51.0, - "partner":"4evd" + "partner":"3t9j" }, { "sim":51.0, - "partner":"4eve" + "partner":"4yif" }, { "sim":51.0, - "partner":"3ta8" + "partner":"4evb" }, { "sim":51.0, - "partner":"3t9j" + "partner":"4evc" }, { "sim":51.0, - "partner":"4yif" + "partner":"4evd" }, { "sim":51.0, - "partner":"4evb" + "partner":"4eve" }, { "sim":51.0, @@ -343151,11 +344341,11 @@ }, { "sim":51.0, - "partner":"4o8t" + "partner":"4o8l" }, { "sim":51.0, - "partner":"4o8l" + "partner":"4o8t" }, { "sim":51.0, @@ -343227,23 +344417,23 @@ }, { "sim":51.0, - "partner":"4njh" + "partner":"4njj" }, { "sim":51.0, - "partner":"4nji" + "partner":"4njk" }, { "sim":51.0, - "partner":"4njj" + "partner":"4njg" }, { "sim":51.0, - "partner":"4njk" + "partner":"4njh" }, { "sim":51.0, - "partner":"4njg" + "partner":"4nji" }, { "sim":51.0, @@ -343257,10 +344447,6 @@ "sim":51.0, "partner":"5b7c" }, - { - "sim":51.0, - "partner":"3sfi" - }, { "sim":51.0, "partner":"3qpl" @@ -343307,15 +344493,15 @@ }, { "sim":51.0, - "partner":"2qhs" + "partner":"3sfi" }, { "sim":51.0, - "partner":"3uux" + "partner":"2qhs" }, { "sim":51.0, - "partner":"5cvd" + "partner":"3uux" }, { "sim":51.0, @@ -343329,6 +344515,10 @@ "sim":51.0, "partner":"3qc1" }, + { + "sim":51.0, + "partner":"5cvd" + }, { "sim":51.0, "partner":"3dtz" @@ -343381,10 +344571,6 @@ "sim":51.0, "partner":"2cm1" }, - { - "sim":51.0, - "partner":"4yvk" - }, { "sim":51.0, "partner":"4yqd" @@ -343409,6 +344595,10 @@ "sim":51.0, "partner":"4yvj" }, + { + "sim":51.0, + "partner":"4yvk" + }, { "sim":51.0, "partner":"1sny" @@ -343439,23 +344629,23 @@ }, { "sim":51.0, - "partner":"1zw3" + "partner":"1zvz" }, { "sim":51.0, - "partner":"6hxo" + "partner":"6hxn" }, { "sim":51.0, - "partner":"1zvz" + "partner":"6hxo" }, { "sim":51.0, - "partner":"6hxn" + "partner":"1zw2" }, { "sim":51.0, - "partner":"1zw2" + "partner":"1zw3" }, { "sim":51.0, @@ -343507,31 +344697,15 @@ }, { "sim":51.0, - "partner":"3jq9" - }, - { - "sim":51.0, - "partner":"4cm3" - }, - { - "sim":51.0, - "partner":"4cmb" - }, - { - "sim":51.0, - "partner":"4rdh" - }, - { - "sim":51.0, - "partner":"5jcj" + "partner":"2yhi" }, { "sim":51.0, - "partner":"6gdp" + "partner":"3bmc" }, { "sim":51.0, - "partner":"6rx0" + "partner":"3jqa" }, { "sim":51.0, @@ -343543,39 +344717,35 @@ }, { "sim":51.0, - "partner":"4rdi" - }, - { - "sim":51.0, - "partner":"6gcl" + "partner":"4cm4" }, { "sim":51.0, - "partner":"2yhi" + "partner":"4cmc" }, { "sim":51.0, - "partner":"3bmc" + "partner":"4rdi" }, { "sim":51.0, - "partner":"4cm4" + "partner":"5jcj" }, { "sim":51.0, - "partner":"4cmc" + "partner":"5k6a" }, { "sim":51.0, - "partner":"5k6a" + "partner":"6gcp" }, { "sim":51.0, - "partner":"3jqa" + "partner":"6gcq" }, { "sim":51.0, - "partner":"6gcp" + "partner":"6gd0" }, { "sim":51.0, @@ -343595,31 +344765,31 @@ }, { "sim":51.0, - "partner":"6gcq" + "partner":"4clr" }, { "sim":51.0, - "partner":"6gd0" + "partner":"4cme" }, { "sim":51.0, - "partner":"4clr" + "partner":"3bmo" }, { "sim":51.0, - "partner":"4cme" + "partner":"4cm6" }, { "sim":51.0, - "partner":"3bmo" + "partner":"3jqc" }, { "sim":51.0, - "partner":"4cm6" + "partner":"6gex" }, { "sim":51.0, - "partner":"3jqc" + "partner":"6tbx" }, { "sim":51.0, @@ -343643,11 +344813,7 @@ }, { "sim":51.0, - "partner":"6gex" - }, - { - "sim":51.0, - "partner":"6tbx" + "partner":"6rx6" }, { "sim":51.0, @@ -343663,27 +344829,23 @@ }, { "sim":51.0, - "partner":"6rx6" - }, - { - "sim":51.0, - "partner":"5jdi" + "partner":"6gey" }, { "sim":51.0, - "partner":"3gn2" + "partner":"6hnc" }, { "sim":51.0, - "partner":"4cle" + "partner":"5jdi" }, { "sim":51.0, - "partner":"6gey" + "partner":"3gn2" }, { "sim":51.0, - "partner":"6hnc" + "partner":"4cle" }, { "sim":51.0, @@ -343703,19 +344865,19 @@ }, { "sim":51.0, - "partner":"2x9v" + "partner":"6gd4" }, { "sim":51.0, - "partner":"4cmi" + "partner":"2x9v" }, { "sim":51.0, - "partner":"5jcx" + "partner":"4cmi" }, { "sim":51.0, - "partner":"6gd4" + "partner":"5jcx" }, { "sim":51.0, @@ -343733,6 +344895,10 @@ "sim":51.0, "partner":"3jqf" }, + { + "sim":51.0, + "partner":"6hnr" + }, { "sim":51.0, "partner":"4cmj" @@ -343751,7 +344917,7 @@ }, { "sim":51.0, - "partner":"6hnr" + "partner":"6how" }, { "sim":51.0, @@ -343761,6 +344927,10 @@ "sim":51.0, "partner":"5djh" }, + { + "sim":51.0, + "partner":"6gdo" + }, { "sim":51.0, "partner":"2x9g" @@ -343783,7 +344953,7 @@ }, { "sim":51.0, - "partner":"6how" + "partner":"6rx0" }, { "sim":51.0, @@ -343795,7 +344965,7 @@ }, { "sim":51.0, - "partner":"6gdo" + "partner":"4rdh" }, { "sim":51.0, @@ -343803,19 +344973,31 @@ }, { "sim":51.0, - "partner":"5e0n" + "partner":"4cm3" }, { "sim":51.0, - "partner":"1xse" + "partner":"4cmb" }, { "sim":51.0, - "partner":"1u1v" + "partner":"6gdp" }, { "sim":51.0, - "partner":"1u1w" + "partner":"3jq9" + }, + { + "sim":51.0, + "partner":"6gcl" + }, + { + "sim":51.0, + "partner":"5e0n" + }, + { + "sim":51.0, + "partner":"1xse" }, { "sim":51.0, @@ -343833,6 +345015,14 @@ "sim":51.0, "partner":"5iwe" }, + { + "sim":51.0, + "partner":"1u1v" + }, + { + "sim":51.0, + "partner":"1u1w" + }, { "sim":51.0, "partner":"6cng" @@ -343861,10 +345051,6 @@ "sim":51.0, "partner":"5dz7" }, - { - "sim":51.0, - "partner":"3ggo" - }, { "sim":51.0, "partner":"3ggp" @@ -343875,11 +345061,11 @@ }, { "sim":51.0, - "partner":"6l3w" + "partner":"3ggo" }, { "sim":51.0, - "partner":"3aio" + "partner":"6l3w" }, { "sim":51.0, @@ -343891,16 +345077,20 @@ }, { "sim":51.0, - "partner":"3aim" + "partner":"6k1r" }, { "sim":51.0, - "partner":"6k1r" + "partner":"3aim" }, { "sim":51.0, "partner":"3ain" }, + { + "sim":51.0, + "partner":"3aio" + }, { "sim":51.0, "partner":"6t2n" @@ -343911,19 +345101,19 @@ }, { "sim":51.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":51.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":51.0, - "partner":"3tm8" + "partner":"3tmc" }, { "sim":51.0, - "partner":"3tmb" + "partner":"3tmd" }, { "sim":51.0, @@ -343931,15 +345121,15 @@ }, { "sim":51.0, - "partner":"2pzm" + "partner":"2pzk" }, { "sim":51.0, - "partner":"2pzk" + "partner":"2pzl" }, { "sim":51.0, - "partner":"2pzl" + "partner":"2pzm" }, { "sim":51.0, @@ -343947,15 +345137,15 @@ }, { "sim":51.0, - "partner":"4w7v" + "partner":"4w7u" }, { "sim":51.0, - "partner":"4w7w" + "partner":"4w7v" }, { "sim":51.0, - "partner":"4w7u" + "partner":"4w7w" }, { "sim":51.0, @@ -343999,15 +345189,15 @@ }, { "sim":51.0, - "partner":"6q4x" + "partner":"6q4z" }, { "sim":51.0, - "partner":"6q4y" + "partner":"6q4x" }, { "sim":51.0, - "partner":"6q4z" + "partner":"6q4y" }, { "sim":51.0, @@ -344019,87 +345209,87 @@ }, { "sim":51.0, - "partner":"1xoq" + "partner":"1y2b" }, { "sim":51.0, - "partner":"6ind" + "partner":"6imt" }, { "sim":51.0, - "partner":"1xor" + "partner":"1y2c" }, { "sim":51.0, - "partner":"3iak" + "partner":"6ink" }, { "sim":51.0, - "partner":"6imr" + "partner":"1y2d" }, { "sim":51.0, - "partner":"1y2b" + "partner":"1y2e" }, { "sim":51.0, - "partner":"6im6" + "partner":"6inm" }, { "sim":51.0, - "partner":"6imt" + "partner":"6imb" }, { "sim":51.0, - "partner":"1y2c" + "partner":"6imd" }, { "sim":51.0, - "partner":"1y2d" + "partner":"1y2k" }, { "sim":51.0, - "partner":"6ink" + "partner":"6imi" }, { "sim":51.0, - "partner":"1y2e" + "partner":"6imo" }, { "sim":51.0, - "partner":"6inm" + "partner":"1xom" }, { "sim":51.0, - "partner":"6imb" + "partner":"1xon" }, { "sim":51.0, - "partner":"6imd" + "partner":"3k4s" }, { "sim":51.0, - "partner":"1y2k" + "partner":"6ind" }, { "sim":51.0, - "partner":"1xom" + "partner":"1xoq" }, { "sim":51.0, - "partner":"6imi" + "partner":"6imr" }, { "sim":51.0, - "partner":"6imo" + "partner":"1xor" }, { "sim":51.0, - "partner":"1xon" + "partner":"6im6" }, { "sim":51.0, - "partner":"3k4s" + "partner":"3iak" }, { "sim":51.0, @@ -344123,31 +345313,31 @@ }, { "sim":51.0, - "partner":"8wpo" + "partner":"8wpj" }, { "sim":51.0, - "partner":"8wph" + "partner":"8wpq" }, { "sim":51.0, - "partner":"8wpi" + "partner":"8wpr" }, { "sim":51.0, - "partner":"8wpj" + "partner":"8wps" }, { "sim":51.0, - "partner":"8wpq" + "partner":"8wpo" }, { "sim":51.0, - "partner":"8wpr" + "partner":"8wph" }, { "sim":51.0, - "partner":"8wps" + "partner":"8wpi" }, { "sim":51.0, @@ -344157,10 +345347,6 @@ "sim":51.0, "partner":"5uqv" }, - { - "sim":51.0, - "partner":"5akd" - }, { "sim":51.0, "partner":"5akb" @@ -344175,23 +345361,11 @@ }, { "sim":51.0, - "partner":"4myg" - }, - { - "sim":51.0, - "partner":"5zzx" - }, - { - "sim":51.0, - "partner":"6a0d" - }, - { - "sim":51.0, - "partner":"5zzy" + "partner":"5akd" }, { "sim":51.0, - "partner":"6a0v" + "partner":"4myg" }, { "sim":51.0, @@ -344335,11 +345509,23 @@ }, { "sim":51.0, - "partner":"3o2t" + "partner":"5zzx" }, { "sim":51.0, - "partner":"5hxu" + "partner":"6a0d" + }, + { + "sim":51.0, + "partner":"5zzy" + }, + { + "sim":51.0, + "partner":"6a0v" + }, + { + "sim":51.0, + "partner":"3o2t" }, { "sim":51.0, @@ -344353,6 +345539,10 @@ "sim":51.0, "partner":"5hwe" }, + { + "sim":51.0, + "partner":"5hxu" + }, { "sim":51.0, "partner":"3dkb" @@ -344377,10 +345567,6 @@ "sim":51.0, "partner":"3k01" }, - { - "sim":51.0, - "partner":"3wkr" - }, { "sim":51.0, "partner":"3wks" @@ -344391,11 +345577,11 @@ }, { "sim":51.0, - "partner":"5xpj" + "partner":"3wkr" }, { "sim":51.0, - "partner":"5dvi" + "partner":"5xpj" }, { "sim":51.0, @@ -344419,27 +345605,15 @@ }, { "sim":51.0, - "partner":"4w4t" - }, - { - "sim":51.0, - "partner":"4u7w" - }, - { - "sim":51.0, - "partner":"6p3v" - }, - { - "sim":51.0, - "partner":"6vur" + "partner":"5dvi" }, { "sim":51.0, - "partner":"6vus" + "partner":"4w4t" }, { "sim":51.0, - "partner":"6vut" + "partner":"4u7w" }, { "sim":51.0, @@ -344459,19 +345633,19 @@ }, { "sim":51.0, - "partner":"5tvj" + "partner":"6vuz" }, { "sim":51.0, - "partner":"6b3t" + "partner":"6vv0" }, { "sim":51.0, - "partner":"6vuz" + "partner":"5tvj" }, { "sim":51.0, - "partner":"6vv0" + "partner":"6b3t" }, { "sim":51.0, @@ -344501,6 +345675,22 @@ "sim":51.0, "partner":"6p3u" }, + { + "sim":51.0, + "partner":"6p3v" + }, + { + "sim":51.0, + "partner":"6vur" + }, + { + "sim":51.0, + "partner":"6vus" + }, + { + "sim":51.0, + "partner":"6vut" + }, { "sim":51.0, "partner":"5u22" @@ -344551,11 +345741,11 @@ }, { "sim":51.0, - "partner":"6f47" + "partner":"6f4e" }, { "sim":51.0, - "partner":"6f4e" + "partner":"6f47" }, { "sim":51.0, @@ -344595,11 +345785,11 @@ }, { "sim":51.0, - "partner":"6ak4" + "partner":"6aej" }, { "sim":51.0, - "partner":"6aej" + "partner":"6ak4" }, { "sim":51.0, @@ -344657,10 +345847,6 @@ "sim":51.0, "partner":"6jzs" }, - { - "sim":51.0, - "partner":"4ie7" - }, { "sim":51.0, "partner":"5vqi" @@ -344709,6 +345895,10 @@ "sim":51.0, "partner":"4qho" }, + { + "sim":51.0, + "partner":"4ie7" + }, { "sim":51.0, "partner":"5gl5" @@ -344735,15 +345925,15 @@ }, { "sim":51.0, - "partner":"5kdn" + "partner":"5kds" }, { "sim":51.0, - "partner":"5kds" + "partner":"5kdu" }, { "sim":51.0, - "partner":"5kdu" + "partner":"5kdn" }, { "sim":51.0, @@ -344783,35 +345973,35 @@ }, { "sim":51.0, - "partner":"3ahc" + "partner":"3ahf" }, { "sim":51.0, - "partner":"3ahd" + "partner":"3ahg" }, { "sim":51.0, - "partner":"3ahe" + "partner":"3ahh" }, { "sim":51.0, - "partner":"3ahf" + "partner":"3ahi" }, { "sim":51.0, - "partner":"3ahg" + "partner":"3ahj" }, { "sim":51.0, - "partner":"3ahh" + "partner":"3ahc" }, { "sim":51.0, - "partner":"3ahi" + "partner":"3ahd" }, { "sim":51.0, - "partner":"3ahj" + "partner":"3ahe" }, { "sim":51.0, @@ -344899,11 +346089,11 @@ }, { "sim":50.0, - "partner":"3imo" + "partner":"3fwu" }, { "sim":50.0, - "partner":"3fwu" + "partner":"3imo" }, { "sim":50.0, @@ -344915,15 +346105,15 @@ }, { "sim":50.0, - "partner":"3qna" + "partner":"3qn0" }, { "sim":50.0, - "partner":"3qn0" + "partner":"3qn9" }, { "sim":50.0, - "partner":"3qn9" + "partner":"3qna" }, { "sim":50.0, @@ -344941,10 +346131,6 @@ "sim":50.0, "partner":"5tg0" }, - { - "sim":50.0, - "partner":"3rg6" - }, { "sim":50.0, "partner":"2wvw" @@ -344963,15 +346149,15 @@ }, { "sim":50.0, - "partner":"4zwq" + "partner":"3rg6" }, { "sim":50.0, - "partner":"4zwr" + "partner":"4zwq" }, { "sim":50.0, - "partner":"6ebc" + "partner":"4zwr" }, { "sim":50.0, @@ -344987,16 +346173,20 @@ }, { "sim":50.0, - "partner":"3t8y" + "partner":"6ebc" }, { "sim":50.0, - "partner":"2o4d" + "partner":"3t8y" }, { "sim":50.0, "partner":"3s9f" }, + { + "sim":50.0, + "partner":"2o4d" + }, { "sim":50.0, "partner":"4qxz" @@ -345011,11 +346201,11 @@ }, { "sim":50.0, - "partner":"2ela" + "partner":"6fxs" }, { "sim":50.0, - "partner":"6fxs" + "partner":"2ela" }, { "sim":50.0, @@ -345039,11 +346229,11 @@ }, { "sim":50.0, - "partner":"6uv7" + "partner":"6uvi" }, { "sim":50.0, - "partner":"6uvi" + "partner":"6uv7" }, { "sim":50.0, @@ -345111,19 +346301,19 @@ }, { "sim":50.0, - "partner":"5n7o" + "partner":"6hry" }, { "sim":50.0, - "partner":"6hry" + "partner":"5n7o" }, { "sim":50.0, - "partner":"5n1c" + "partner":"6hrz" }, { "sim":50.0, - "partner":"6hrz" + "partner":"5n1c" }, { "sim":50.0, @@ -345135,11 +346325,11 @@ }, { "sim":50.0, - "partner":"3qh2" + "partner":"6hs2" }, { "sim":50.0, - "partner":"6hs2" + "partner":"3qh2" }, { "sim":50.0, @@ -345203,11 +346393,11 @@ }, { "sim":50.0, - "partner":"3bgi" + "partner":"3bgd" }, { "sim":50.0, - "partner":"3bgd" + "partner":"3bgi" }, { "sim":50.0, @@ -345245,10 +346435,6 @@ "sim":50.0, "partner":"3kmr" }, - { - "sim":50.0, - "partner":"4jyi" - }, { "sim":50.0, "partner":"4dm6" @@ -345275,15 +346461,15 @@ }, { "sim":50.0, - "partner":"4dml" + "partner":"4jyi" }, { "sim":50.0, - "partner":"4dmm" + "partner":"4dml" }, { "sim":50.0, - "partner":"4m7t" + "partner":"4dmm" }, { "sim":50.0, @@ -345295,11 +346481,7 @@ }, { "sim":50.0, - "partner":"5ds3" - }, - { - "sim":50.0, - "partner":"6bhv" + "partner":"4m7t" }, { "sim":50.0, @@ -345329,6 +346511,14 @@ "sim":50.0, "partner":"6nrj" }, + { + "sim":50.0, + "partner":"6bhv" + }, + { + "sim":50.0, + "partner":"5ds3" + }, { "sim":50.0, "partner":"3p8a" @@ -345369,14 +346559,6 @@ "sim":50.0, "partner":"4bwv" }, - { - "sim":50.0, - "partner":"3quo" - }, - { - "sim":50.0, - "partner":"3qvf" - }, { "sim":50.0, "partner":"3qur" @@ -345399,24 +346581,20 @@ }, { "sim":50.0, - "partner":"5coq" + "partner":"3quo" }, { "sim":50.0, - "partner":"5cpb" + "partner":"3qvf" }, { "sim":50.0, - "partner":"5mtr" + "partner":"4oxk" }, { "sim":50.0, "partner":"5ugt" }, - { - "sim":50.0, - "partner":"4oxk" - }, { "sim":50.0, "partner":"5ugu" @@ -345457,10 +346635,22 @@ "sim":50.0, "partner":"5cp8" }, + { + "sim":50.0, + "partner":"5mtr" + }, { "sim":50.0, "partner":"5ugs" }, + { + "sim":50.0, + "partner":"5cpb" + }, + { + "sim":50.0, + "partner":"5coq" + }, { "sim":50.0, "partner":"4oxp" @@ -345475,11 +346665,11 @@ }, { "sim":50.0, - "partner":"3ta4" + "partner":"3t9w" }, { "sim":50.0, - "partner":"3t9w" + "partner":"3ta4" }, { "sim":50.0, @@ -345489,10 +346679,6 @@ "sim":50.0, "partner":"8r2x" }, - { - "sim":50.0, - "partner":"3s3h" - }, { "sim":50.0, "partner":"3s3k" @@ -345507,15 +346693,15 @@ }, { "sim":50.0, - "partner":"2zni" + "partner":"3s3h" }, { "sim":50.0, - "partner":"2znj" + "partner":"2zni" }, { "sim":50.0, - "partner":"3g3d" + "partner":"2znj" }, { "sim":50.0, @@ -345537,6 +346723,10 @@ "sim":50.0, "partner":"4hkp" }, + { + "sim":50.0, + "partner":"3g3d" + }, { "sim":50.0, "partner":"5mqv" @@ -345565,10 +346755,6 @@ "sim":50.0, "partner":"6f26" }, - { - "sim":50.0, - "partner":"3u3r" - }, { "sim":50.0, "partner":"3u3k" @@ -345581,6 +346767,10 @@ "sim":50.0, "partner":"3u3o" }, + { + "sim":50.0, + "partner":"3u3r" + }, { "sim":50.0, "partner":"5wri" @@ -345631,15 +346821,15 @@ }, { "sim":50.0, - "partner":"5y1f" + "partner":"6unx" }, { "sim":50.0, - "partner":"5y1g" + "partner":"5y1f" }, { "sim":50.0, - "partner":"6unx" + "partner":"5y1g" }, { "sim":50.0, @@ -345729,10 +346919,6 @@ "sim":50.0, "partner":"5v8y" }, - { - "sim":50.0, - "partner":"5jyf" - }, { "sim":50.0, "partner":"5v8x" @@ -345761,6 +346947,10 @@ "sim":50.0, "partner":"5jye" }, + { + "sim":50.0, + "partner":"5jyf" + }, { "sim":50.0, "partner":"3kzm" @@ -345815,31 +347005,31 @@ }, { "sim":50.0, - "partner":"6fm0" + "partner":"6fm3" }, { "sim":50.0, - "partner":"6rm2" + "partner":"4j2o" }, { "sim":50.0, - "partner":"6fko" + "partner":"6flf" }, { "sim":50.0, - "partner":"6fm1" + "partner":"6fm0" }, { "sim":50.0, - "partner":"4j2o" + "partner":"6rm2" }, { "sim":50.0, - "partner":"6fm3" + "partner":"6fko" }, { "sim":50.0, - "partner":"6flf" + "partner":"6fm1" }, { "sim":50.0, @@ -345853,10 +347043,6 @@ "sim":50.0, "partner":"4rct" }, - { - "sim":50.0, - "partner":"4m1i" - }, { "sim":50.0, "partner":"4d8f" @@ -345869,6 +347055,10 @@ "sim":50.0, "partner":"4m1h" }, + { + "sim":50.0, + "partner":"4m1i" + }, { "sim":50.0, "partner":"2pvp" @@ -345887,15 +347077,11 @@ }, { "sim":50.0, - "partner":"6vkk" - }, - { - "sim":50.0, - "partner":"6vkq" + "partner":"3vaq" }, { "sim":50.0, - "partner":"3vaq" + "partner":"6vko" }, { "sim":50.0, @@ -345903,11 +347089,11 @@ }, { "sim":50.0, - "partner":"6vko" + "partner":"6vkk" }, { "sim":50.0, - "partner":"2iua" + "partner":"6vkq" }, { "sim":50.0, @@ -345917,6 +347103,10 @@ "sim":50.0, "partner":"2iu9" }, + { + "sim":50.0, + "partner":"2iua" + }, { "sim":50.0, "partner":"2pzj" @@ -345953,14 +347143,6 @@ "sim":50.0, "partner":"4ock" }, - { - "sim":50.0, - "partner":"4q3r" - }, - { - "sim":50.0, - "partner":"4q42" - }, { "sim":50.0, "partner":"4q3s" @@ -345997,6 +347179,14 @@ "sim":50.0, "partner":"4q41" }, + { + "sim":50.0, + "partner":"4q3r" + }, + { + "sim":50.0, + "partner":"4q42" + }, { "sim":50.0, "partner":"3fvm" @@ -346029,10 +347219,6 @@ "sim":50.0, "partner":"4zah" }, - { - "sim":50.0, - "partner":"2elb" - }, { "sim":50.0, "partner":"5oq2" @@ -346047,7 +347233,7 @@ }, { "sim":50.0, - "partner":"5ta7" + "partner":"2elb" }, { "sim":50.0, @@ -346057,6 +347243,10 @@ "sim":50.0, "partner":"3vax" }, + { + "sim":50.0, + "partner":"5ta7" + }, { "sim":50.0, "partner":"3jzj" @@ -346073,18 +347263,6 @@ "sim":50.0, "partner":"6p5r" }, - { - "sim":50.0, - "partner":"2y46" - }, - { - "sim":50.0, - "partner":"2y5n" - }, - { - "sim":50.0, - "partner":"2yca" - }, { "sim":50.0, "partner":"4c2j" @@ -346115,7 +347293,19 @@ }, { "sim":50.0, - "partner":"4euh" + "partner":"2y46" + }, + { + "sim":50.0, + "partner":"2y5n" + }, + { + "sim":50.0, + "partner":"2yca" + }, + { + "sim":50.0, + "partner":"8s53" }, { "sim":50.0, @@ -346131,7 +347321,7 @@ }, { "sim":50.0, - "partner":"5xw2" + "partner":"4euh" }, { "sim":50.0, @@ -346141,6 +347331,10 @@ "sim":50.0, "partner":"1pie" }, + { + "sim":50.0, + "partner":"5xw2" + }, { "sim":50.0, "partner":"3s8m" @@ -346225,10 +347419,6 @@ "sim":50.0, "partner":"3s6k" }, - { - "sim":50.0, - "partner":"6oi8" - }, { "sim":50.0, "partner":"4mv1" @@ -346267,15 +347457,19 @@ }, { "sim":50.0, - "partner":"2gps" + "partner":"6oi8" }, { "sim":50.0, - "partner":"6oi9" + "partner":"2gpw" }, { "sim":50.0, - "partner":"2gpw" + "partner":"2gps" + }, + { + "sim":50.0, + "partner":"6oi9" }, { "sim":50.0, @@ -346381,10 +347575,6 @@ "sim":50.0, "partner":"4lh3" }, - { - "sim":50.0, - "partner":"2q5l" - }, { "sim":50.0, "partner":"2q5o" @@ -346403,19 +347593,19 @@ }, { "sim":50.0, - "partner":"3nvl" + "partner":"2q5l" }, { "sim":50.0, - "partner":"6dqx" + "partner":"3nvl" }, { "sim":50.0, - "partner":"6j1f" + "partner":"6dqx" }, { "sim":50.0, - "partner":"6j1e" + "partner":"6j1f" }, { "sim":50.0, @@ -346439,7 +347629,7 @@ }, { "sim":50.0, - "partner":"5tsh" + "partner":"6j1e" }, { "sim":50.0, @@ -346449,6 +347639,10 @@ "sim":50.0, "partner":"5tsg" }, + { + "sim":50.0, + "partner":"5tsh" + }, { "sim":50.0, "partner":"6uzl" @@ -346463,15 +347657,15 @@ }, { "sim":50.0, - "partner":"5lj7" + "partner":"5lil" }, { "sim":50.0, - "partner":"5lil" + "partner":"5lj6" }, { "sim":50.0, - "partner":"5lj6" + "partner":"5lj7" }, { "sim":50.0, @@ -346523,15 +347717,15 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"6edz" }, { "sim":50.0, - "partner":"6edz" + "partner":"6ee1" }, { "sim":50.0, - "partner":"6ee1" + "partner":"6edw" }, { "sim":50.0, @@ -346543,15 +347737,15 @@ }, { "sim":50.0, - "partner":"6tsh" + "partner":"6tsk" }, { "sim":50.0, - "partner":"6tte" + "partner":"6tsh" }, { "sim":50.0, - "partner":"6tsk" + "partner":"6tte" }, { "sim":50.0, @@ -346640,82 +347834,82 @@ ], "subtitle":"De novo designed rossmann fold protein ros2_835", "tags":[ - "rossmann fold", - "de novo protein" + "de novo protein", + "rossmann fold" ], "keywords":[ + "geometries", + "designed", + "lucs", + "designing", + "offers", + "naturally", + "design", + "sampling", + "space", + "structural", + "17", "diverse", - "designs", - "mimics", + "encompassing", + "structures", + "well", + "expands", + "families", + "experimentally", + "different", "overall", "tested", - "proteins", - "solved", - "greatly", - "combinatorial", - "families", - "also", - "four", - "elements", - "topologies", - "matched", + "16", + "structure", "fold", - "including", - "method", - "designed", - "geometries", - "well", - "may", - "different", - "expands", - "highly", - "encompassing", - "shapes", - "lucs", - "found", - "optimal", - "vary", + "elements", + "novel", + "new", + "also", + "closely", "precisely", - "two", + "functions", + "matched", + "designable", "nature", - "experimentally", - "closely", - "occurring", - "unit", - "ability", + "biophysical", + "topologies", + "vary", + "function", "folded", - "functions", + "known", + "unit", + "proteins", "38", - "design", - "sampling", - "characterization", - "structures", - "naturally", - "precise", - "surpassing", + "customizable", + "mimics", "generates", - "present", - "45", - "offers", - "paradigm", - "space", - "designing", - "structure", - "function", + "characterization", "showed", - "17", - "16", - "distinct", - "computational", - "designable", + "greatly", + "ability", + "may", + "shapes", + "45", + "combinatorial", + "highly", "tunable", - "known", - "novel", - "structural", + "distinct", + "solved", + "found", + "surpassing", + "two", + "present", + "precise", + "four", "create", - "biophysical", - "new", - "customizable" + "optimal", + "method", + "designs", + "computational", + "including", + "paradigm", + "occurring" ], "release_date":"2020-08-19", "publication":"\"Expanding the space of protein geometries by computational design of de novo fold families\", Science, 369, 1132-1136", @@ -346756,11 +347950,11 @@ }, { "sim":88.0, - "partner":"2kpo" + "partner":"2lv8" }, { "sim":88.0, - "partner":"2lv8" + "partner":"2kpo" }, { "sim":55.0, @@ -346772,11 +347966,11 @@ }, { "sim":53.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":53.0, - "partner":"8w08" + "partner":"8v0a" }, { "sim":52.0, @@ -346788,11 +347982,11 @@ }, { "sim":51.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":51.0, - "partner":"8w05" + "partner":"8w06" }, { "sim":50.0, @@ -346828,10 +348022,6 @@ "sim":60.0, "partner":"4n2y" }, - { - "sim":59.0, - "partner":"3la7" - }, { "sim":59.0, "partner":"3la2" @@ -346844,17 +348034,21 @@ "sim":59.0, "partner":"3qc1" }, + { + "sim":59.0, + "partner":"3la7" + }, { "sim":58.0, "partner":"4mtz" }, { "sim":58.0, - "partner":"4oxc" + "partner":"6gjw" }, { "sim":58.0, - "partner":"6gjw" + "partner":"4oxc" }, { "sim":58.0, @@ -346910,24 +348104,12 @@ }, { "sim":57.0, - "partner":"5coq" - }, - { - "sim":57.0, - "partner":"5cpb" - }, - { - "sim":57.0, - "partner":"5mtr" + "partner":"4oxk" }, { "sim":57.0, "partner":"5ugt" }, - { - "sim":57.0, - "partner":"4oxk" - }, { "sim":57.0, "partner":"5ugu" @@ -346968,13 +348150,21 @@ "sim":57.0, "partner":"5cp8" }, + { + "sim":57.0, + "partner":"5mtr" + }, { "sim":57.0, "partner":"5ugs" }, { "sim":57.0, - "partner":"3aio" + "partner":"5cpb" + }, + { + "sim":57.0, + "partner":"5coq" }, { "sim":57.0, @@ -346992,6 +348182,10 @@ "sim":57.0, "partner":"3ain" }, + { + "sim":57.0, + "partner":"3aio" + }, { "sim":57.0, "partner":"5fd4" @@ -347054,15 +348248,15 @@ }, { "sim":56.0, - "partner":"3n39" + "partner":"3n3a" }, { "sim":56.0, - "partner":"3n3a" + "partner":"3n3b" }, { "sim":56.0, - "partner":"3n3b" + "partner":"3n39" }, { "sim":56.0, @@ -347130,15 +348324,15 @@ }, { "sim":56.0, - "partner":"2gps" + "partner":"2gpw" }, { "sim":56.0, - "partner":"6oi9" + "partner":"2gps" }, { "sim":56.0, - "partner":"2gpw" + "partner":"6oi9" }, { "sim":56.0, @@ -347160,10 +348354,6 @@ "sim":55.0, "partner":"5j4f" }, - { - "sim":55.0, - "partner":"5zrk" - }, { "sim":55.0, "partner":"5zrl" @@ -347200,6 +348390,10 @@ "sim":55.0, "partner":"5zri" }, + { + "sim":55.0, + "partner":"5zrk" + }, { "sim":55.0, "partner":"4lfk" @@ -347270,27 +348464,15 @@ }, { "sim":55.0, - "partner":"3jq9" - }, - { - "sim":55.0, - "partner":"4cm3" - }, - { - "sim":55.0, - "partner":"4cmb" - }, - { - "sim":55.0, - "partner":"5jcj" + "partner":"2yhi" }, { "sim":55.0, - "partner":"6gdp" + "partner":"3bmc" }, { "sim":55.0, - "partner":"6rx0" + "partner":"3jqa" }, { "sim":55.0, @@ -347302,35 +348484,31 @@ }, { "sim":55.0, - "partner":"6gcl" - }, - { - "sim":55.0, - "partner":"2yhi" + "partner":"4cm4" }, { "sim":55.0, - "partner":"3bmc" + "partner":"4cmc" }, { "sim":55.0, - "partner":"4cm4" + "partner":"5jcj" }, { "sim":55.0, - "partner":"4cmc" + "partner":"5k6a" }, { "sim":55.0, - "partner":"5k6a" + "partner":"6gcp" }, { "sim":55.0, - "partner":"3jqa" + "partner":"6gcq" }, { "sim":55.0, - "partner":"6gcp" + "partner":"6gd0" }, { "sim":55.0, @@ -347350,31 +348528,31 @@ }, { "sim":55.0, - "partner":"6gcq" + "partner":"4clr" }, { "sim":55.0, - "partner":"6gd0" + "partner":"4cme" }, { "sim":55.0, - "partner":"4clr" + "partner":"3bmo" }, { "sim":55.0, - "partner":"4cme" + "partner":"4cm6" }, { "sim":55.0, - "partner":"3bmo" + "partner":"3jqc" }, { "sim":55.0, - "partner":"4cm6" + "partner":"6gex" }, { "sim":55.0, - "partner":"3jqc" + "partner":"6tbx" }, { "sim":55.0, @@ -347398,11 +348576,7 @@ }, { "sim":55.0, - "partner":"6gex" - }, - { - "sim":55.0, - "partner":"6tbx" + "partner":"6rx6" }, { "sim":55.0, @@ -347418,27 +348592,23 @@ }, { "sim":55.0, - "partner":"6rx6" - }, - { - "sim":55.0, - "partner":"5jdi" + "partner":"6gey" }, { "sim":55.0, - "partner":"3gn2" + "partner":"6hnc" }, { "sim":55.0, - "partner":"4cle" + "partner":"5jdi" }, { "sim":55.0, - "partner":"6gey" + "partner":"3gn2" }, { "sim":55.0, - "partner":"6hnc" + "partner":"4cle" }, { "sim":55.0, @@ -347458,19 +348628,19 @@ }, { "sim":55.0, - "partner":"2x9v" + "partner":"6gd4" }, { "sim":55.0, - "partner":"4cmi" + "partner":"2x9v" }, { "sim":55.0, - "partner":"5jcx" + "partner":"4cmi" }, { "sim":55.0, - "partner":"6gd4" + "partner":"5jcx" }, { "sim":55.0, @@ -347488,6 +348658,10 @@ "sim":55.0, "partner":"3jqf" }, + { + "sim":55.0, + "partner":"6hnr" + }, { "sim":55.0, "partner":"4cmj" @@ -347498,12 +348672,16 @@ }, { "sim":55.0, - "partner":"6hnr" + "partner":"6how" }, { "sim":55.0, "partner":"4cma" }, + { + "sim":55.0, + "partner":"6gdo" + }, { "sim":55.0, "partner":"2x9g" @@ -347522,7 +348700,7 @@ }, { "sim":55.0, - "partner":"6how" + "partner":"6rx0" }, { "sim":55.0, @@ -347530,7 +348708,23 @@ }, { "sim":55.0, - "partner":"6gdo" + "partner":"4cm3" + }, + { + "sim":55.0, + "partner":"4cmb" + }, + { + "sim":55.0, + "partner":"6gdp" + }, + { + "sim":55.0, + "partner":"3jq9" + }, + { + "sim":55.0, + "partner":"6gcl" }, { "sim":55.0, @@ -347568,10 +348762,6 @@ "sim":55.0, "partner":"4o1f" }, - { - "sim":55.0, - "partner":"5ybr" - }, { "sim":55.0, "partner":"5ybs" @@ -347600,6 +348790,10 @@ "sim":55.0, "partner":"5ybq" }, + { + "sim":55.0, + "partner":"5ybr" + }, { "sim":55.0, "partner":"5wri" @@ -347644,17 +348838,13 @@ "sim":55.0, "partner":"1pie" }, - { - "sim":55.0, - "partner":"3amu" - }, { "sim":55.0, "partner":"3amt" }, { "sim":55.0, - "partner":"2cj9" + "partner":"3amu" }, { "sim":55.0, @@ -347670,11 +348860,11 @@ }, { "sim":55.0, - "partner":"6j1f" + "partner":"2cj9" }, { "sim":55.0, - "partner":"6j1e" + "partner":"6j1f" }, { "sim":55.0, @@ -347688,6 +348878,10 @@ "sim":55.0, "partner":"6j0p" }, + { + "sim":55.0, + "partner":"6j1e" + }, { "sim":54.0, "partner":"3p8b" @@ -347730,7 +348924,7 @@ }, { "sim":54.0, - "partner":"5edd" + "partner":"8p8o" }, { "sim":54.0, @@ -347762,15 +348956,15 @@ }, { "sim":54.0, - "partner":"8p8o" + "partner":"1sm8" }, { "sim":54.0, - "partner":"1sm8" + "partner":"3hza" }, { "sim":54.0, - "partner":"3hza" + "partner":"5edd" }, { "sim":54.0, @@ -347850,15 +349044,15 @@ }, { "sim":54.0, - "partner":"5kdn" + "partner":"5kds" }, { "sim":54.0, - "partner":"5kds" + "partner":"5kdu" }, { "sim":54.0, - "partner":"5kdu" + "partner":"5kdn" }, { "sim":54.0, @@ -348056,17 +349250,13 @@ "sim":53.0, "partner":"1yb2" }, - { - "sim":53.0, - "partner":"6hxo" - }, { "sim":53.0, "partner":"6hxn" }, { "sim":53.0, - "partner":"6fcn" + "partner":"6hxo" }, { "sim":53.0, @@ -348076,6 +349266,10 @@ "sim":53.0, "partner":"6fcm" }, + { + "sim":53.0, + "partner":"6fcn" + }, { "sim":53.0, "partner":"4bwv" @@ -348116,10 +349310,6 @@ "sim":53.0, "partner":"5l4l" }, - { - "sim":53.0, - "partner":"3g3d" - }, { "sim":53.0, "partner":"3bvj" @@ -348136,6 +349326,10 @@ "sim":53.0, "partner":"4hkp" }, + { + "sim":53.0, + "partner":"3g3d" + }, { "sim":53.0, "partner":"5ybl" @@ -348152,10 +349346,6 @@ "sim":53.0, "partner":"5zl1" }, - { - "sim":53.0, - "partner":"2pzm" - }, { "sim":53.0, "partner":"2qry" @@ -348168,6 +349358,10 @@ "sim":53.0, "partner":"2pzl" }, + { + "sim":53.0, + "partner":"2pzm" + }, { "sim":53.0, "partner":"3auz" @@ -348184,14 +349378,6 @@ "sim":53.0, "partner":"4xzz" }, - { - "sim":53.0, - "partner":"4h2w" - }, - { - "sim":53.0, - "partner":"3mey" - }, { "sim":53.0, "partner":"4h2x" @@ -348228,6 +349414,14 @@ "sim":53.0, "partner":"4h2v" }, + { + "sim":53.0, + "partner":"4h2w" + }, + { + "sim":53.0, + "partner":"3mey" + }, { "sim":53.0, "partner":"4dr0" @@ -348242,23 +349436,23 @@ }, { "sim":53.0, - "partner":"6fm0" + "partner":"6fm3" }, { "sim":53.0, - "partner":"6rm2" + "partner":"6flf" }, { "sim":53.0, - "partner":"6fko" + "partner":"6fm0" }, { "sim":53.0, - "partner":"6fm3" + "partner":"6rm2" }, { "sim":53.0, - "partner":"6flf" + "partner":"6fko" }, { "sim":53.0, @@ -348280,10 +349474,6 @@ "sim":53.0, "partner":"5xnh" }, - { - "sim":53.0, - "partner":"4zhs" - }, { "sim":53.0, "partner":"2rjg" @@ -348312,6 +349502,10 @@ "sim":53.0, "partner":"4zic" }, + { + "sim":53.0, + "partner":"4zhs" + }, { "sim":53.0, "partner":"3av0" @@ -348364,10 +349558,6 @@ "sim":53.0, "partner":"3nmz" }, - { - "sim":53.0, - "partner":"6oi8" - }, { "sim":53.0, "partner":"4mv1" @@ -348404,6 +349594,10 @@ "sim":53.0, "partner":"6ojh" }, + { + "sim":53.0, + "partner":"6oi8" + }, { "sim":53.0, "partner":"1tz7" @@ -348422,27 +349616,27 @@ }, { "sim":53.0, - "partner":"4ids" + "partner":"4lem" }, { "sim":53.0, - "partner":"4jdc" + "partner":"4idm" }, { "sim":53.0, - "partner":"4lem" + "partner":"4ns3" }, { "sim":53.0, - "partner":"4idm" + "partner":"4ihi" }, { "sim":53.0, - "partner":"4ns3" + "partner":"4ids" }, { "sim":53.0, - "partner":"4ihi" + "partner":"4jdc" }, { "sim":53.0, @@ -348450,15 +349644,15 @@ }, { "sim":53.0, - "partner":"5tsh" + "partner":"6olj" }, { "sim":53.0, - "partner":"6olj" + "partner":"5tsg" }, { "sim":53.0, - "partner":"5tsg" + "partner":"5tsh" }, { "sim":53.0, @@ -348642,11 +349836,11 @@ }, { "sim":52.0, - "partner":"4rdh" + "partner":"4rdi" }, { "sim":52.0, - "partner":"4rdi" + "partner":"4rdh" }, { "sim":52.0, @@ -348668,10 +349862,6 @@ "sim":52.0, "partner":"5uto" }, - { - "sim":52.0, - "partner":"3ggo" - }, { "sim":52.0, "partner":"3ggp" @@ -348694,7 +349884,7 @@ }, { "sim":52.0, - "partner":"3u3r" + "partner":"3ggo" }, { "sim":52.0, @@ -348710,11 +349900,7 @@ }, { "sim":52.0, - "partner":"3tmc" - }, - { - "sim":52.0, - "partner":"3tmd" + "partner":"3u3r" }, { "sim":52.0, @@ -348730,19 +349916,19 @@ }, { "sim":52.0, - "partner":"6q75" + "partner":"3tmc" }, { "sim":52.0, - "partner":"4mfz" + "partner":"3tmd" }, { "sim":52.0, - "partner":"6q4x" + "partner":"6q75" }, { "sim":52.0, - "partner":"6q4y" + "partner":"4mfz" }, { "sim":52.0, @@ -348750,11 +349936,11 @@ }, { "sim":52.0, - "partner":"4mfj" + "partner":"6q4x" }, { "sim":52.0, - "partner":"4mfk" + "partner":"6q4y" }, { "sim":52.0, @@ -348762,31 +349948,31 @@ }, { "sim":52.0, - "partner":"6iix" + "partner":"4mfp" }, { "sim":52.0, - "partner":"4mfp" + "partner":"4mfq" }, { "sim":52.0, - "partner":"4mfq" + "partner":"4mfj" }, { "sim":52.0, - "partner":"3rny" + "partner":"6iix" }, { "sim":52.0, - "partner":"6ef6" + "partner":"4mfk" }, { "sim":52.0, - "partner":"1x19" + "partner":"3rny" }, { "sim":52.0, - "partner":"1x1a" + "partner":"6ef6" }, { "sim":52.0, @@ -348800,6 +349986,14 @@ "sim":52.0, "partner":"1x1d" }, + { + "sim":52.0, + "partner":"1x19" + }, + { + "sim":52.0, + "partner":"1x1a" + }, { "sim":52.0, "partner":"5x06" @@ -348866,11 +350060,11 @@ }, { "sim":52.0, - "partner":"6f47" + "partner":"6f4e" }, { "sim":52.0, - "partner":"6f4e" + "partner":"6f47" }, { "sim":52.0, @@ -349002,11 +350196,11 @@ }, { "sim":51.0, - "partner":"5cvo" + "partner":"6nyo" }, { "sim":51.0, - "partner":"6nyo" + "partner":"5cvo" }, { "sim":51.0, @@ -349046,15 +350240,15 @@ }, { "sim":51.0, - "partner":"4hmr" + "partner":"4hls" }, { "sim":51.0, - "partner":"4hls" + "partner":"4hmm" }, { "sim":51.0, - "partner":"4hmm" + "partner":"4hmr" }, { "sim":51.0, @@ -349084,10 +350278,6 @@ "sim":51.0, "partner":"4elz" }, - { - "sim":51.0, - "partner":"3rg6" - }, { "sim":51.0, "partner":"2wvw" @@ -349104,6 +350294,10 @@ "sim":51.0, "partner":"2peo" }, + { + "sim":51.0, + "partner":"3rg6" + }, { "sim":51.0, "partner":"6tr8" @@ -349122,11 +350316,11 @@ }, { "sim":51.0, - "partner":"2ls6" + "partner":"6bws" }, { "sim":51.0, - "partner":"6bws" + "partner":"2ls6" }, { "sim":51.0, @@ -349144,10 +350338,6 @@ "sim":51.0, "partner":"5cab" }, - { - "sim":51.0, - "partner":"1vb6" - }, { "sim":51.0, "partner":"1v9y" @@ -349160,6 +350350,10 @@ "sim":51.0, "partner":"2fek" }, + { + "sim":51.0, + "partner":"1vb6" + }, { "sim":51.0, "partner":"5c7p" @@ -349174,15 +350368,15 @@ }, { "sim":51.0, - "partner":"4gzc" + "partner":"4gzd" }, { "sim":51.0, - "partner":"4gzd" + "partner":"5zrt" }, { "sim":51.0, - "partner":"5zrt" + "partner":"4gzc" }, { "sim":51.0, @@ -349246,11 +350440,11 @@ }, { "sim":51.0, - "partner":"1wc6" + "partner":"1wc1" }, { "sim":51.0, - "partner":"1wc1" + "partner":"1wc6" }, { "sim":51.0, @@ -349334,11 +350528,11 @@ }, { "sim":51.0, - "partner":"2f9t" + "partner":"6non" }, { "sim":51.0, - "partner":"6non" + "partner":"2f9t" }, { "sim":51.0, @@ -349428,10 +350622,6 @@ "sim":51.0, "partner":"4pne" }, - { - "sim":51.0, - "partner":"3ws7" - }, { "sim":51.0, "partner":"5xvh" @@ -349446,15 +350636,7 @@ }, { "sim":51.0, - "partner":"3nc2" - }, - { - "sim":51.0, - "partner":"3q92" - }, - { - "sim":51.0, - "partner":"3ro4" + "partner":"3ws7" }, { "sim":51.0, @@ -349504,6 +350686,18 @@ "sim":51.0, "partner":"3qa2" }, + { + "sim":51.0, + "partner":"3nc2" + }, + { + "sim":51.0, + "partner":"3q92" + }, + { + "sim":51.0, + "partner":"3ro4" + }, { "sim":51.0, "partner":"5mqv" @@ -349618,16 +350812,12 @@ }, { "sim":51.0, - "partner":"5l9l" + "partner":"6tg2" }, { "sim":51.0, "partner":"4h3k" }, - { - "sim":51.0, - "partner":"6tg2" - }, { "sim":51.0, "partner":"5l9p" @@ -349654,35 +350844,35 @@ }, { "sim":51.0, - "partner":"8wpo" + "partner":"5l9l" }, { "sim":51.0, - "partner":"8wph" + "partner":"8wpj" }, { "sim":51.0, - "partner":"8wpi" + "partner":"8wpq" }, { "sim":51.0, - "partner":"8wpj" + "partner":"8wpr" }, { "sim":51.0, - "partner":"8wpq" + "partner":"8wps" }, { "sim":51.0, - "partner":"8wpr" + "partner":"8wpo" }, { "sim":51.0, - "partner":"8wps" + "partner":"8wph" }, { "sim":51.0, - "partner":"4m1i" + "partner":"8wpi" }, { "sim":51.0, @@ -349698,11 +350888,11 @@ }, { "sim":51.0, - "partner":"2pvp" + "partner":"4m1i" }, { "sim":51.0, - "partner":"5akd" + "partner":"2pvp" }, { "sim":51.0, @@ -349714,11 +350904,11 @@ }, { "sim":51.0, - "partner":"4myg" + "partner":"5akd" }, { "sim":51.0, - "partner":"5f5m" + "partner":"4myg" }, { "sim":51.0, @@ -349726,28 +350916,12 @@ }, { "sim":51.0, - "partner":"3c1y" - }, - { - "sim":51.0, - "partner":"5zzx" - }, - { - "sim":51.0, - "partner":"6a0d" + "partner":"5f5m" }, { "sim":51.0, "partner":"3c1z" }, - { - "sim":51.0, - "partner":"5zzy" - }, - { - "sim":51.0, - "partner":"6a0v" - }, { "sim":51.0, "partner":"5zzz" @@ -349926,27 +351100,39 @@ }, { "sim":51.0, - "partner":"4rzs" + "partner":"3c1y" }, { "sim":51.0, - "partner":"4rzt" + "partner":"5zzx" }, { "sim":51.0, - "partner":"3o2t" + "partner":"6a0d" }, { "sim":51.0, - "partner":"2qdh" + "partner":"5zzy" }, { "sim":51.0, - "partner":"6kjh" + "partner":"6a0v" }, { "sim":51.0, - "partner":"6kjj" + "partner":"4rzs" + }, + { + "sim":51.0, + "partner":"4rzt" + }, + { + "sim":51.0, + "partner":"3o2t" + }, + { + "sim":51.0, + "partner":"2qdh" }, { "sim":51.0, @@ -349972,6 +351158,14 @@ "sim":51.0, "partner":"2qdg" }, + { + "sim":51.0, + "partner":"6kjh" + }, + { + "sim":51.0, + "partner":"6kjj" + }, { "sim":51.0, "partner":"3vvl" @@ -350038,11 +351232,11 @@ }, { "sim":51.0, - "partner":"3wkr" + "partner":"3wks" }, { "sim":51.0, - "partner":"3wks" + "partner":"3wkr" }, { "sim":51.0, @@ -350072,10 +351266,6 @@ "sim":51.0, "partner":"3mco" }, - { - "sim":51.0, - "partner":"2imc" - }, { "sim":51.0, "partner":"2ilp" @@ -350102,15 +351292,15 @@ }, { "sim":51.0, - "partner":"5xwb" + "partner":"2imc" }, { "sim":51.0, - "partner":"3deb" + "partner":"5xwb" }, { "sim":51.0, - "partner":"5v1s" + "partner":"3deb" }, { "sim":51.0, @@ -350120,6 +351310,10 @@ "sim":51.0, "partner":"5v1q" }, + { + "sim":51.0, + "partner":"5v1s" + }, { "sim":51.0, "partner":"4j1q" @@ -350232,10 +351426,6 @@ "sim":51.0, "partner":"5n6l" }, - { - "sim":51.0, - "partner":"2r0p" - }, { "sim":51.0, "partner":"2r0c" @@ -350248,6 +351438,10 @@ "sim":51.0, "partner":"3ept" }, + { + "sim":51.0, + "partner":"2r0p" + }, { "sim":51.0, "partner":"8rpf" @@ -350268,10 +351462,6 @@ "sim":51.0, "partner":"5uqn" }, - { - "sim":51.0, - "partner":"2q5l" - }, { "sim":51.0, "partner":"2q5o" @@ -350290,12 +351480,16 @@ }, { "sim":51.0, - "partner":"5ess" + "partner":"2q5l" }, { "sim":51.0, "partner":"5esd" }, + { + "sim":51.0, + "partner":"5ess" + }, { "sim":51.0, "partner":"6o0j" @@ -350350,15 +351544,15 @@ }, { "sim":51.0, - "partner":"5lj7" + "partner":"5lil" }, { "sim":51.0, - "partner":"5lil" + "partner":"5lj6" }, { "sim":51.0, - "partner":"5lj6" + "partner":"5lj7" }, { "sim":51.0, @@ -350422,15 +351616,15 @@ }, { "sim":50.0, - "partner":"5ho3" + "partner":"6iwj" }, { "sim":50.0, - "partner":"6iwj" + "partner":"5ho1" }, { "sim":50.0, - "partner":"5ho1" + "partner":"5ho3" }, { "sim":50.0, @@ -350442,11 +351636,11 @@ }, { "sim":50.0, - "partner":"2y78" + "partner":"6g62" }, { "sim":50.0, - "partner":"6g62" + "partner":"2y78" }, { "sim":50.0, @@ -350482,11 +351676,11 @@ }, { "sim":50.0, - "partner":"5eri" + "partner":"5uh7" }, { "sim":50.0, - "partner":"5uh7" + "partner":"5eri" }, { "sim":50.0, @@ -350506,19 +351700,19 @@ }, { "sim":50.0, - "partner":"2h16" + "partner":"5eg9" }, { "sim":50.0, - "partner":"5eg9" + "partner":"2h16" }, { "sim":50.0, - "partner":"6uv7" + "partner":"6uvi" }, { "sim":50.0, - "partner":"6uvi" + "partner":"6uv7" }, { "sim":50.0, @@ -350532,10 +351726,6 @@ "sim":50.0, "partner":"5w10" }, - { - "sim":50.0, - "partner":"5wg9" - }, { "sim":50.0, "partner":"5wap" @@ -350638,15 +351828,15 @@ }, { "sim":50.0, - "partner":"3w2z" + "partner":"5wg9" }, { "sim":50.0, - "partner":"6a4c" + "partner":"3w2z" }, { "sim":50.0, - "partner":"5bnq" + "partner":"6a4c" }, { "sim":50.0, @@ -350656,6 +351846,10 @@ "sim":50.0, "partner":"3me4" }, + { + "sim":50.0, + "partner":"5bnq" + }, { "sim":50.0, "partner":"2fzl" @@ -350708,10 +351902,6 @@ "sim":50.0, "partner":"1vjb" }, - { - "sim":50.0, - "partner":"4da6" - }, { "sim":50.0, "partner":"4da7" @@ -350766,19 +351956,19 @@ }, { "sim":50.0, - "partner":"2h5y" + "partner":"4da6" }, { "sim":50.0, - "partner":"4dg7" + "partner":"2h5y" }, { "sim":50.0, - "partner":"5owf" + "partner":"4dg7" }, { "sim":50.0, - "partner":"4be6" + "partner":"5owf" }, { "sim":50.0, @@ -350814,7 +352004,7 @@ }, { "sim":50.0, - "partner":"4yvk" + "partner":"4be6" }, { "sim":50.0, @@ -350840,6 +352030,10 @@ "sim":50.0, "partner":"4yvj" }, + { + "sim":50.0, + "partner":"4yvk" + }, { "sim":50.0, "partner":"5a7z" @@ -350850,11 +352044,11 @@ }, { "sim":50.0, - "partner":"5tii" + "partner":"5thq" }, { "sim":50.0, - "partner":"5thq" + "partner":"5tii" }, { "sim":50.0, @@ -350918,15 +352112,19 @@ }, { "sim":50.0, - "partner":"5uj3" + "partner":"8rwq" }, { "sim":50.0, - "partner":"5uj4" + "partner":"6mnp" }, { "sim":50.0, - "partner":"6mnp" + "partner":"8rwr" + }, + { + "sim":50.0, + "partner":"5uj3" }, { "sim":50.0, @@ -350934,7 +352132,11 @@ }, { "sim":50.0, - "partner":"5ul8" + "partner":"8rws" + }, + { + "sim":50.0, + "partner":"5uj4" }, { "sim":50.0, @@ -350950,7 +352152,7 @@ }, { "sim":50.0, - "partner":"4oxp" + "partner":"5ul8" }, { "sim":50.0, @@ -350960,6 +352162,10 @@ "sim":50.0, "partner":"6d19" }, + { + "sim":50.0, + "partner":"4oxp" + }, { "sim":50.0, "partner":"6qw9" @@ -350976,10 +352182,6 @@ "sim":50.0, "partner":"6qwc" }, - { - "sim":50.0, - "partner":"1zct" - }, { "sim":50.0, "partner":"6qwd" @@ -350990,7 +352192,7 @@ }, { "sim":50.0, - "partner":"8rwq" + "partner":"1zct" }, { "sim":50.0, @@ -351016,6 +352218,14 @@ "sim":50.0, "partner":"6td1" }, + { + "sim":50.0, + "partner":"8rwo" + }, + { + "sim":50.0, + "partner":"8rwp" + }, { "sim":50.0, "partner":"3usq" @@ -351070,11 +352280,7 @@ }, { "sim":50.0, - "partner":"3h26" - }, - { - "sim":50.0, - "partner":"1twz" + "partner":"1tx0" }, { "sim":50.0, @@ -351084,10 +352290,6 @@ "sim":50.0, "partner":"4d8a" }, - { - "sim":50.0, - "partner":"1tx0" - }, { "sim":50.0, "partner":"1tx2" @@ -351202,11 +352404,11 @@ }, { "sim":50.0, - "partner":"1u1v" + "partner":"3h26" }, { "sim":50.0, - "partner":"1u1w" + "partner":"1twz" }, { "sim":50.0, @@ -351224,6 +352426,14 @@ "sim":50.0, "partner":"5iwe" }, + { + "sim":50.0, + "partner":"1u1v" + }, + { + "sim":50.0, + "partner":"1u1w" + }, { "sim":50.0, "partner":"3h85" @@ -351260,10 +352470,6 @@ "sim":50.0, "partner":"5teu" }, - { - "sim":50.0, - "partner":"3s3h" - }, { "sim":50.0, "partner":"3s3k" @@ -351276,6 +352482,10 @@ "sim":50.0, "partner":"3s3f" }, + { + "sim":50.0, + "partner":"3s3h" + }, { "sim":50.0, "partner":"2zni" @@ -351336,14 +352546,6 @@ "sim":50.0, "partner":"5czl" }, - { - "sim":50.0, - "partner":"5gg5" - }, - { - "sim":50.0, - "partner":"5xd1" - }, { "sim":50.0, "partner":"5gg6" @@ -351394,11 +352596,11 @@ }, { "sim":50.0, - "partner":"5glm" + "partner":"5gg5" }, { "sim":50.0, - "partner":"5gln" + "partner":"5xd1" }, { "sim":50.0, @@ -351424,6 +352626,14 @@ "sim":50.0, "partner":"5gll" }, + { + "sim":50.0, + "partner":"5glm" + }, + { + "sim":50.0, + "partner":"5gln" + }, { "sim":50.0, "partner":"3ren" @@ -351480,14 +352690,6 @@ "sim":50.0, "partner":"4is4" }, - { - "sim":50.0, - "partner":"4q3r" - }, - { - "sim":50.0, - "partner":"4q42" - }, { "sim":50.0, "partner":"4q3s" @@ -351520,6 +352722,14 @@ "sim":50.0, "partner":"4q41" }, + { + "sim":50.0, + "partner":"4q3r" + }, + { + "sim":50.0, + "partner":"4q42" + }, { "sim":50.0, "partner":"3fvm" @@ -351538,16 +352748,12 @@ }, { "sim":50.0, - "partner":"5hxu" + "partner":"5hy1" }, { "sim":50.0, "partner":"5tzb" }, - { - "sim":50.0, - "partner":"5hy1" - }, { "sim":50.0, "partner":"5hxz" @@ -351558,15 +352764,15 @@ }, { "sim":50.0, - "partner":"3dkb" + "partner":"5hxu" }, { "sim":50.0, - "partner":"6c8v" + "partner":"3dkb" }, { "sim":50.0, - "partner":"2elb" + "partner":"6c8v" }, { "sim":50.0, @@ -351578,7 +352784,7 @@ }, { "sim":50.0, - "partner":"2y6r" + "partner":"2elb" }, { "sim":50.0, @@ -351600,6 +352806,10 @@ "sim":50.0, "partner":"2y6q" }, + { + "sim":50.0, + "partner":"2y6r" + }, { "sim":50.0, "partner":"2f2s" @@ -351668,22 +352878,6 @@ "sim":50.0, "partner":"4u7w" }, - { - "sim":50.0, - "partner":"6p3v" - }, - { - "sim":50.0, - "partner":"6vur" - }, - { - "sim":50.0, - "partner":"6vus" - }, - { - "sim":50.0, - "partner":"6vut" - }, { "sim":50.0, "partner":"6vuu" @@ -351702,19 +352896,19 @@ }, { "sim":50.0, - "partner":"5tvj" + "partner":"6vuz" }, { "sim":50.0, - "partner":"6b3t" + "partner":"6vv0" }, { "sim":50.0, - "partner":"6vuz" + "partner":"5tvj" }, { "sim":50.0, - "partner":"6vv0" + "partner":"6b3t" }, { "sim":50.0, @@ -351750,35 +352944,43 @@ }, { "sim":50.0, - "partner":"5akq" + "partner":"6p3v" }, { "sim":50.0, - "partner":"4cqb" + "partner":"6vur" }, { "sim":50.0, - "partner":"4cqc" + "partner":"6vus" }, { "sim":50.0, - "partner":"4cqd" + "partner":"6vut" }, { "sim":50.0, - "partner":"3m89" + "partner":"5akq" }, { "sim":50.0, - "partner":"3ihm" + "partner":"4cqb" }, { "sim":50.0, - "partner":"2ca0" + "partner":"4cqc" }, { "sim":50.0, - "partner":"4b7s" + "partner":"4cqd" + }, + { + "sim":50.0, + "partner":"3m89" + }, + { + "sim":50.0, + "partner":"3ihm" }, { "sim":50.0, @@ -351826,11 +353028,15 @@ }, { "sim":50.0, - "partner":"4doy" + "partner":"2ca0" }, { "sim":50.0, - "partner":"5z8a" + "partner":"4b7s" + }, + { + "sim":50.0, + "partner":"4doy" }, { "sim":50.0, @@ -351846,27 +353052,31 @@ }, { "sim":50.0, - "partner":"6ry0" + "partner":"5z8a" }, { "sim":50.0, - "partner":"6ry1" + "partner":"6ry5" }, { "sim":50.0, - "partner":"6ry2" + "partner":"6ry6" }, { "sim":50.0, - "partner":"6ry5" + "partner":"6ry7" }, { "sim":50.0, - "partner":"6ry6" + "partner":"6ry0" }, { "sim":50.0, - "partner":"6ry7" + "partner":"6ry1" + }, + { + "sim":50.0, + "partner":"6ry2" }, { "sim":50.0, @@ -351898,23 +353108,23 @@ }, { "sim":50.0, - "partner":"6mp7" + "partner":"6moy" }, { "sim":50.0, - "partner":"6mpa" + "partner":"6mpc" }, { "sim":50.0, - "partner":"6moy" + "partner":"6mp2" }, { "sim":50.0, - "partner":"6mpc" + "partner":"6mp7" }, { "sim":50.0, - "partner":"6mp2" + "partner":"6mpa" }, { "sim":50.0, @@ -351960,14 +353170,6 @@ "sim":50.0, "partner":"6qps" }, - { - "sim":50.0, - "partner":"6mlh" - }, - { - "sim":50.0, - "partner":"6mlw" - }, { "sim":50.0, "partner":"6nn1" @@ -351994,19 +353196,23 @@ }, { "sim":50.0, - "partner":"6bia" + "partner":"6mlh" }, { "sim":50.0, - "partner":"5kr3" + "partner":"6mlw" }, { "sim":50.0, - "partner":"3oqc" + "partner":"6bia" }, { "sim":50.0, - "partner":"4cdm" + "partner":"5kr3" + }, + { + "sim":50.0, + "partner":"3oqc" }, { "sim":50.0, @@ -352024,6 +353230,10 @@ "sim":50.0, "partner":"5zcw" }, + { + "sim":50.0, + "partner":"4cdm" + }, { "sim":50.0, "partner":"6rim" @@ -352062,7 +353272,7 @@ }, { "sim":50.0, - "partner":"5m12" + "partner":"6gwg" }, { "sim":50.0, @@ -352070,31 +353280,31 @@ }, { "sim":50.0, - "partner":"6gwf" + "partner":"6gta" }, { "sim":50.0, - "partner":"6gwg" + "partner":"5m16" }, { "sim":50.0, - "partner":"5m16" + "partner":"6gvd" }, { "sim":50.0, - "partner":"6gta" + "partner":"5m0x" }, { "sim":50.0, - "partner":"6gvd" + "partner":"6gx8" }, { "sim":50.0, - "partner":"5m0x" + "partner":"5m12" }, { "sim":50.0, - "partner":"6gx8" + "partner":"6gwf" }, { "sim":50.0, @@ -352132,18 +353342,6 @@ "sim":50.0, "partner":"1ry2" }, - { - "sim":50.0, - "partner":"4b73" - }, - { - "sim":50.0, - "partner":"4b74" - }, - { - "sim":50.0, - "partner":"5fpy" - }, { "sim":50.0, "partner":"4b75" @@ -352184,6 +353382,18 @@ "sim":50.0, "partner":"4b71" }, + { + "sim":50.0, + "partner":"4b73" + }, + { + "sim":50.0, + "partner":"4b74" + }, + { + "sim":50.0, + "partner":"5fpy" + }, { "sim":50.0, "partner":"4b6e" @@ -352355,82 +353565,82 @@ ], "subtitle":"De novo designed rossmann fold protein ros2_36830", "tags":[ - "rossmann fold", - "de novo protein" + "de novo protein", + "rossmann fold" ], "keywords":[ + "geometries", + "designed", + "lucs", + "designing", + "offers", + "naturally", + "design", + "sampling", + "space", + "structural", + "17", "diverse", - "designs", - "mimics", + "encompassing", + "structures", + "well", + "expands", + "families", + "experimentally", + "different", "overall", "tested", - "proteins", - "solved", - "greatly", - "combinatorial", - "families", - "also", - "four", - "elements", - "topologies", - "matched", + "16", + "structure", "fold", - "including", - "method", - "designed", - "geometries", - "well", - "may", - "different", - "expands", - "highly", - "encompassing", - "shapes", - "lucs", - "found", - "optimal", - "vary", + "elements", + "novel", + "new", + "also", + "closely", "precisely", - "two", + "functions", + "matched", + "designable", "nature", - "experimentally", - "closely", - "occurring", - "unit", - "ability", + "biophysical", + "topologies", + "vary", + "function", "folded", - "functions", + "known", + "unit", + "proteins", "38", - "design", - "sampling", - "characterization", - "structures", - "naturally", - "precise", - "surpassing", + "customizable", + "mimics", "generates", - "present", - "45", - "offers", - "paradigm", - "space", - "designing", - "structure", - "function", + "characterization", "showed", - "17", - "16", - "distinct", - "computational", - "designable", + "greatly", + "ability", + "may", + "shapes", + "45", + "combinatorial", + "highly", "tunable", - "known", - "novel", - "structural", + "distinct", + "solved", + "found", + "surpassing", + "two", + "present", + "precise", + "four", "create", - "biophysical", - "new", - "customizable" + "optimal", + "method", + "designs", + "computational", + "including", + "paradigm", + "occurring" ], "release_date":"2020-08-19", "publication":"\"Expanding the space of protein geometries by computational design of de novo fold families\", Science, 369, 1132-1136", @@ -352471,11 +353681,11 @@ }, { "sim":93.0, - "partner":"2kpo" + "partner":"2lv8" }, { "sim":93.0, - "partner":"2lv8" + "partner":"2kpo" }, { "sim":55.0, @@ -352483,27 +353693,27 @@ }, { "sim":54.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":54.0, - "partner":"8w05" + "partner":"8w06" }, { "sim":53.0, - "partner":"8qae" + "partner":"8qad" }, { "sim":53.0, - "partner":"8qad" + "partner":"8qae" }, { "sim":53.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":53.0, - "partner":"8w08" + "partner":"8v0a" }, { "sim":52.0, @@ -352515,18 +353725,14 @@ }, { "sim":51.0, - "partner":"8v2w" + "partner":"8v09" }, { "sim":51.0, - "partner":"8v09" + "partner":"8v2w" } ], "seq_thr_sim_natural":[ - { - "sim":59.0, - "partner":"3c1y" - }, { "sim":59.0, "partner":"3c1z" @@ -352551,6 +353757,10 @@ "sim":59.0, "partner":"4yxm" }, + { + "sim":59.0, + "partner":"3c1y" + }, { "sim":58.0, "partner":"1x9a" @@ -352669,15 +353879,15 @@ }, { "sim":55.0, - "partner":"6q4x" + "partner":"6q4z" }, { "sim":55.0, - "partner":"6q4y" + "partner":"6q4x" }, { "sim":55.0, - "partner":"6q4z" + "partner":"6q4y" }, { "sim":55.0, @@ -352751,17 +353961,13 @@ "sim":54.0, "partner":"4hye" }, - { - "sim":54.0, - "partner":"1wc6" - }, { "sim":54.0, "partner":"1wc1" }, { "sim":54.0, - "partner":"3la7" + "partner":"1wc6" }, { "sim":54.0, @@ -352771,6 +353977,10 @@ "sim":54.0, "partner":"3la3" }, + { + "sim":54.0, + "partner":"3la7" + }, { "sim":54.0, "partner":"2zvw" @@ -352851,10 +354061,6 @@ "sim":54.0, "partner":"4yiw" }, - { - "sim":54.0, - "partner":"4cdm" - }, { "sim":54.0, "partner":"4cdn" @@ -352871,6 +354077,10 @@ "sim":54.0, "partner":"5zcw" }, + { + "sim":54.0, + "partner":"4cdm" + }, { "sim":54.0, "partner":"8rpf" @@ -353025,11 +354235,11 @@ }, { "sim":53.0, - "partner":"6nko" + "partner":"2dch" }, { "sim":53.0, - "partner":"2dch" + "partner":"6nko" }, { "sim":53.0, @@ -353067,10 +354277,6 @@ "sim":53.0, "partner":"2olk" }, - { - "sim":53.0, - "partner":"1z5z" - }, { "sim":53.0, "partner":"6lua" @@ -353091,6 +354297,10 @@ "sim":53.0, "partner":"5umi" }, + { + "sim":53.0, + "partner":"1z5z" + }, { "sim":53.0, "partner":"4y7k" @@ -353139,14 +354349,6 @@ "sim":53.0, "partner":"1tz6" }, - { - "sim":53.0, - "partner":"4h2w" - }, - { - "sim":53.0, - "partner":"3mey" - }, { "sim":53.0, "partner":"4h2x" @@ -353183,6 +354385,14 @@ "sim":53.0, "partner":"4h2v" }, + { + "sim":53.0, + "partner":"4h2w" + }, + { + "sim":53.0, + "partner":"3mey" + }, { "sim":53.0, "partner":"3ren" @@ -353241,27 +354451,27 @@ }, { "sim":53.0, - "partner":"6ry0" + "partner":"6ry5" }, { "sim":53.0, - "partner":"6ry1" + "partner":"6ry6" }, { "sim":53.0, - "partner":"6ry2" + "partner":"6ry7" }, { "sim":53.0, - "partner":"6ry5" + "partner":"6ry0" }, { "sim":53.0, - "partner":"6ry6" + "partner":"6ry1" }, { "sim":53.0, - "partner":"6ry7" + "partner":"6ry2" }, { "sim":53.0, @@ -353375,10 +354585,6 @@ "sim":52.0, "partner":"6v4x" }, - { - "sim":52.0, - "partner":"3rg6" - }, { "sim":52.0, "partner":"2wvw" @@ -353391,6 +354597,10 @@ "sim":52.0, "partner":"2peo" }, + { + "sim":52.0, + "partner":"3rg6" + }, { "sim":52.0, "partner":"4lfk" @@ -353475,10 +354685,6 @@ "sim":52.0, "partner":"3uic" }, - { - "sim":52.0, - "partner":"4j3f" - }, { "sim":52.0, "partner":"4j4t" @@ -353493,16 +354699,20 @@ }, { "sim":52.0, - "partner":"3bd9" + "partner":"4j3f" }, { "sim":52.0, - "partner":"4jqc" + "partner":"3bd9" }, { "sim":52.0, "partner":"4jx8" }, + { + "sim":52.0, + "partner":"4jqc" + }, { "sim":52.0, "partner":"5l3z" @@ -353519,10 +354729,6 @@ "sim":52.0, "partner":"5l4l" }, - { - "sim":52.0, - "partner":"2pzm" - }, { "sim":52.0, "partner":"2qry" @@ -353535,6 +354741,10 @@ "sim":52.0, "partner":"2pzl" }, + { + "sim":52.0, + "partner":"2pzm" + }, { "sim":52.0, "partner":"4ilk" @@ -353551,10 +354761,6 @@ "sim":52.0, "partner":"3wnd" }, - { - "sim":52.0, - "partner":"6put" - }, { "sim":52.0, "partner":"6puw" @@ -353567,13 +354773,17 @@ "sim":52.0, "partner":"6v3k" }, + { + "sim":52.0, + "partner":"6puz" + }, { "sim":52.0, "partner":"5u1c" }, { "sim":52.0, - "partner":"6puz" + "partner":"6put" }, { "sim":52.0, @@ -353643,18 +354853,6 @@ "sim":52.0, "partner":"2hix" }, - { - "sim":52.0, - "partner":"4b73" - }, - { - "sim":52.0, - "partner":"4b74" - }, - { - "sim":52.0, - "partner":"5fpy" - }, { "sim":52.0, "partner":"4b75" @@ -353695,6 +354893,18 @@ "sim":52.0, "partner":"4b71" }, + { + "sim":52.0, + "partner":"4b73" + }, + { + "sim":52.0, + "partner":"4b74" + }, + { + "sim":52.0, + "partner":"5fpy" + }, { "sim":52.0, "partner":"4b6e" @@ -353765,11 +354975,11 @@ }, { "sim":51.0, - "partner":"4oxc" + "partner":"6gjw" }, { "sim":51.0, - "partner":"6gjw" + "partner":"4oxc" }, { "sim":51.0, @@ -353811,10 +355021,6 @@ "sim":51.0, "partner":"3w6v" }, - { - "sim":51.0, - "partner":"3n39" - }, { "sim":51.0, "partner":"3n3a" @@ -353827,6 +355033,10 @@ "sim":51.0, "partner":"3wbg" }, + { + "sim":51.0, + "partner":"3n39" + }, { "sim":51.0, "partner":"4y1u" @@ -353897,7 +355107,7 @@ }, { "sim":51.0, - "partner":"5edd" + "partner":"8p8o" }, { "sim":51.0, @@ -353931,10 +355141,6 @@ "sim":51.0, "partner":"3loj" }, - { - "sim":51.0, - "partner":"8p8o" - }, { "sim":51.0, "partner":"1sm8" @@ -353953,12 +355159,16 @@ }, { "sim":51.0, - "partner":"4hr7" + "partner":"5edd" }, { "sim":51.0, "partner":"3q93" }, + { + "sim":51.0, + "partner":"4hr7" + }, { "sim":51.0, "partner":"4kl9" @@ -353989,11 +355199,11 @@ }, { "sim":51.0, - "partner":"1x24" + "partner":"1zcl" }, { "sim":51.0, - "partner":"1zcl" + "partner":"1x24" }, { "sim":51.0, @@ -354041,11 +355251,11 @@ }, { "sim":51.0, - "partner":"4jr4" + "partner":"4jr6" }, { "sim":51.0, - "partner":"4jr6" + "partner":"4jr4" }, { "sim":51.0, @@ -354085,15 +355295,15 @@ }, { "sim":51.0, - "partner":"5cvd" + "partner":"5cve" }, { "sim":51.0, - "partner":"5cve" + "partner":"6kdq" }, { "sim":51.0, - "partner":"6kdq" + "partner":"5cvd" }, { "sim":51.0, @@ -354101,11 +355311,11 @@ }, { "sim":51.0, - "partner":"2ho1" + "partner":"5lsu" }, { "sim":51.0, - "partner":"5lsu" + "partner":"2ho1" }, { "sim":51.0, @@ -354125,15 +355335,15 @@ }, { "sim":51.0, - "partner":"5h5a" + "partner":"5h54" }, { "sim":51.0, - "partner":"5h54" + "partner":"5owf" }, { "sim":51.0, - "partner":"5owf" + "partner":"5h5a" }, { "sim":51.0, @@ -354197,11 +355407,11 @@ }, { "sim":51.0, - "partner":"6y65" + "partner":"3jyy" }, { "sim":51.0, - "partner":"3jyy" + "partner":"6y65" }, { "sim":51.0, @@ -354221,11 +355431,11 @@ }, { "sim":51.0, - "partner":"4rdh" + "partner":"4rdi" }, { "sim":51.0, - "partner":"4rdi" + "partner":"4rdh" }, { "sim":51.0, @@ -354281,11 +355491,7 @@ }, { "sim":51.0, - "partner":"3h26" - }, - { - "sim":51.0, - "partner":"1twz" + "partner":"1tx0" }, { "sim":51.0, @@ -354295,10 +355501,6 @@ "sim":51.0, "partner":"4d8a" }, - { - "sim":51.0, - "partner":"1tx0" - }, { "sim":51.0, "partner":"1tx2" @@ -354417,15 +355619,19 @@ }, { "sim":51.0, - "partner":"4x9x" + "partner":"3h26" }, { "sim":51.0, - "partner":"3u3j" + "partner":"1twz" }, { "sim":51.0, - "partner":"3u3r" + "partner":"4x9x" + }, + { + "sim":51.0, + "partner":"3u3j" }, { "sim":51.0, @@ -354439,6 +355645,10 @@ "sim":51.0, "partner":"3u3o" }, + { + "sim":51.0, + "partner":"3u3r" + }, { "sim":51.0, "partner":"6kly" @@ -354455,10 +355665,6 @@ "sim":51.0, "partner":"4iwy" }, - { - "sim":51.0, - "partner":"3aio" - }, { "sim":51.0, "partner":"4lrs" @@ -354483,25 +355689,29 @@ "sim":51.0, "partner":"3ain" }, + { + "sim":51.0, + "partner":"3aio" + }, { "sim":51.0, "partner":"5h55" }, { "sim":51.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":51.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":51.0, - "partner":"3tm8" + "partner":"3tmc" }, { "sim":51.0, - "partner":"3tmb" + "partner":"3tmd" }, { "sim":51.0, @@ -354537,15 +355747,15 @@ }, { "sim":51.0, - "partner":"4bf9" + "partner":"5czl" }, { "sim":51.0, - "partner":"4bfa" + "partner":"4bf9" }, { "sim":51.0, - "partner":"5czl" + "partner":"4bfa" }, { "sim":51.0, @@ -354553,31 +355763,31 @@ }, { "sim":51.0, - "partner":"4mfj" + "partner":"4mfl" }, { "sim":51.0, - "partner":"4mfk" + "partner":"4mfp" }, { "sim":51.0, - "partner":"4mfl" + "partner":"6fu4" }, { "sim":51.0, - "partner":"6iix" + "partner":"4mfq" }, { "sim":51.0, - "partner":"4mfp" + "partner":"4mfj" }, { "sim":51.0, - "partner":"4mfq" + "partner":"6iix" }, { "sim":51.0, - "partner":"6fu4" + "partner":"4mfk" }, { "sim":51.0, @@ -354591,10 +355801,6 @@ "sim":51.0, "partner":"6jif" }, - { - "sim":51.0, - "partner":"5akd" - }, { "sim":51.0, "partner":"5akb" @@ -354605,15 +355811,15 @@ }, { "sim":51.0, - "partner":"4myg" + "partner":"5akd" }, { "sim":51.0, - "partner":"6voy" + "partner":"4myg" }, { "sim":51.0, - "partner":"2y6r" + "partner":"6voy" }, { "sim":51.0, @@ -354635,6 +355841,10 @@ "sim":51.0, "partner":"2y6q" }, + { + "sim":51.0, + "partner":"2y6r" + }, { "sim":51.0, "partner":"4mmw" @@ -354717,15 +355927,15 @@ }, { "sim":51.0, - "partner":"5dvi" + "partner":"5dvj" }, { "sim":51.0, - "partner":"5dvj" + "partner":"5dvf" }, { "sim":51.0, - "partner":"5dvf" + "partner":"5dvi" }, { "sim":51.0, @@ -354759,10 +355969,6 @@ "sim":51.0, "partner":"3zlh" }, - { - "sim":51.0, - "partner":"6oi8" - }, { "sim":51.0, "partner":"4mv1" @@ -354819,6 +356025,10 @@ "sim":51.0, "partner":"6ojh" }, + { + "sim":51.0, + "partner":"6oi8" + }, { "sim":51.0, "partner":"3tai" @@ -354851,10 +356061,6 @@ "sim":51.0, "partner":"3oqc" }, - { - "sim":51.0, - "partner":"2cj9" - }, { "sim":51.0, "partner":"2cja" @@ -354869,7 +356075,7 @@ }, { "sim":51.0, - "partner":"5kdn" + "partner":"2cj9" }, { "sim":51.0, @@ -354879,6 +356085,10 @@ "sim":51.0, "partner":"5kdu" }, + { + "sim":51.0, + "partner":"5kdn" + }, { "sim":51.0, "partner":"5n6h" @@ -354959,10 +356169,6 @@ "sim":51.0, "partner":"6j1f" }, - { - "sim":51.0, - "partner":"6j1e" - }, { "sim":51.0, "partner":"6j1h" @@ -354979,6 +356185,10 @@ "sim":51.0, "partner":"6j0p" }, + { + "sim":51.0, + "partner":"6j1e" + }, { "sim":51.0, "partner":"3t0t" @@ -354993,15 +356203,15 @@ }, { "sim":51.0, - "partner":"5lj7" + "partner":"5lil" }, { "sim":51.0, - "partner":"5lil" + "partner":"5lj6" }, { "sim":51.0, - "partner":"5lj6" + "partner":"5lj7" }, { "sim":51.0, @@ -355013,43 +356223,43 @@ }, { "sim":51.0, - "partner":"2yii" + "partner":"4c5u" }, { "sim":51.0, - "partner":"4c5s" + "partner":"4cq5" }, { "sim":51.0, - "partner":"4v2r" + "partner":"4baa" }, { "sim":51.0, - "partner":"4c5u" + "partner":"4c6g" }, { "sim":51.0, - "partner":"4cq5" + "partner":"4bab" }, { "sim":51.0, - "partner":"4baa" + "partner":"4c5r" }, { "sim":51.0, - "partner":"4c6g" + "partner":"2yii" }, { "sim":51.0, - "partner":"4bab" + "partner":"4v2q" }, { "sim":51.0, - "partner":"4c5r" + "partner":"4c5s" }, { "sim":51.0, - "partner":"4v2q" + "partner":"4v2r" }, { "sim":51.0, @@ -355109,11 +356319,11 @@ }, { "sim":50.0, - "partner":"5cvo" + "partner":"6nyo" }, { "sim":50.0, - "partner":"6nyo" + "partner":"5cvo" }, { "sim":50.0, @@ -355145,11 +356355,11 @@ }, { "sim":50.0, - "partner":"3ssq" + "partner":"6aq7" }, { "sim":50.0, - "partner":"6aq7" + "partner":"3ssq" }, { "sim":50.0, @@ -355167,10 +356377,6 @@ "sim":50.0, "partner":"3ctg" }, - { - "sim":50.0, - "partner":"4hmr" - }, { "sim":50.0, "partner":"2wgn" @@ -355185,19 +356391,19 @@ }, { "sim":50.0, - "partner":"3fwt" + "partner":"4hmr" }, { "sim":50.0, - "partner":"3fwu" + "partner":"3fwt" }, { "sim":50.0, - "partner":"2oba" + "partner":"3fwu" }, { "sim":50.0, - "partner":"5zrk" + "partner":"2oba" }, { "sim":50.0, @@ -355227,6 +356433,10 @@ "sim":50.0, "partner":"5zri" }, + { + "sim":50.0, + "partner":"5zrk" + }, { "sim":50.0, "partner":"4pdb" @@ -355255,10 +356465,6 @@ "sim":50.0, "partner":"6buz" }, - { - "sim":50.0, - "partner":"6ebc" - }, { "sim":50.0, "partner":"6ebd" @@ -355271,6 +356477,10 @@ "sim":50.0, "partner":"6eb4" }, + { + "sim":50.0, + "partner":"6ebc" + }, { "sim":50.0, "partner":"6bws" @@ -355309,11 +356519,11 @@ }, { "sim":50.0, - "partner":"4o8t" + "partner":"4o8l" }, { "sim":50.0, - "partner":"4o8l" + "partner":"4o8t" }, { "sim":50.0, @@ -355483,17 +356693,13 @@ "sim":50.0, "partner":"2wis" }, - { - "sim":50.0, - "partner":"3bgi" - }, { "sim":50.0, "partner":"3bgd" }, { "sim":50.0, - "partner":"4yvk" + "partner":"3bgi" }, { "sim":50.0, @@ -355521,16 +356727,20 @@ }, { "sim":50.0, - "partner":"4m7t" + "partner":"4yvk" }, { "sim":50.0, - "partner":"1l2j" + "partner":"4m7t" }, { "sim":50.0, "partner":"6non" }, + { + "sim":50.0, + "partner":"1l2j" + }, { "sim":50.0, "partner":"5t1v" @@ -355605,11 +356815,11 @@ }, { "sim":50.0, - "partner":"1z6k" + "partner":"6cb2" }, { "sim":50.0, - "partner":"6cb2" + "partner":"1z6k" }, { "sim":50.0, @@ -355621,28 +356831,24 @@ }, { "sim":50.0, - "partner":"6mql" + "partner":"6mqb" }, { "sim":50.0, - "partner":"6mq9" + "partner":"6mqk" }, { "sim":50.0, - "partner":"6mqb" + "partner":"6mql" }, { "sim":50.0, - "partner":"6mqk" + "partner":"6mq9" }, { "sim":50.0, "partner":"4biu" }, - { - "sim":50.0, - "partner":"4rtl" - }, { "sim":50.0, "partner":"4rtm" @@ -355711,6 +356917,10 @@ "sim":50.0, "partner":"4rtk" }, + { + "sim":50.0, + "partner":"4rtl" + }, { "sim":50.0, "partner":"6b2v" @@ -355727,10 +356937,6 @@ "sim":50.0, "partner":"4rw5" }, - { - "sim":50.0, - "partner":"3ws7" - }, { "sim":50.0, "partner":"5xvh" @@ -355743,6 +356949,10 @@ "sim":50.0, "partner":"3w6z" }, + { + "sim":50.0, + "partner":"3ws7" + }, { "sim":50.0, "partner":"2zni" @@ -355769,11 +356979,11 @@ }, { "sim":50.0, - "partner":"5zmy" + "partner":"6f1w" }, { "sim":50.0, - "partner":"6f1w" + "partner":"5zmy" }, { "sim":50.0, @@ -355815,14 +357025,6 @@ "sim":50.0, "partner":"2f9y" }, - { - "sim":50.0, - "partner":"5glm" - }, - { - "sim":50.0, - "partner":"5gln" - }, { "sim":50.0, "partner":"5glo" @@ -355849,7 +357051,11 @@ }, { "sim":50.0, - "partner":"5l9l" + "partner":"5glm" + }, + { + "sim":50.0, + "partner":"5gln" }, { "sim":50.0, @@ -355871,6 +357077,10 @@ "sim":50.0, "partner":"5l9i" }, + { + "sim":50.0, + "partner":"5l9l" + }, { "sim":50.0, "partner":"6gpn" @@ -355977,11 +357187,11 @@ }, { "sim":50.0, - "partner":"6s0g" + "partner":"6s23" }, { "sim":50.0, - "partner":"6s23" + "partner":"6s0g" }, { "sim":50.0, @@ -356001,11 +357211,11 @@ }, { "sim":50.0, - "partner":"3wkr" + "partner":"3wks" }, { "sim":50.0, - "partner":"3wks" + "partner":"3wkr" }, { "sim":50.0, @@ -356025,11 +357235,11 @@ }, { "sim":50.0, - "partner":"3amu" + "partner":"3amt" }, { "sim":50.0, - "partner":"3amt" + "partner":"3amu" }, { "sim":50.0, @@ -356063,10 +357273,6 @@ "sim":50.0, "partner":"3hun" }, - { - "sim":50.0, - "partner":"2z67" - }, { "sim":50.0, "partner":"4dcs" @@ -356085,15 +357291,15 @@ }, { "sim":50.0, - "partner":"2yl9" + "partner":"2z67" }, { "sim":50.0, - "partner":"3nmz" + "partner":"2yl9" }, { "sim":50.0, - "partner":"6f47" + "partner":"3nmz" }, { "sim":50.0, @@ -356101,11 +357307,7 @@ }, { "sim":50.0, - "partner":"6mlh" - }, - { - "sim":50.0, - "partner":"6mlw" + "partner":"6f47" }, { "sim":50.0, @@ -356133,12 +357335,20 @@ }, { "sim":50.0, - "partner":"4dqv" + "partner":"6mlh" + }, + { + "sim":50.0, + "partner":"6mlw" }, { "sim":50.0, "partner":"4u5q" }, + { + "sim":50.0, + "partner":"4dqv" + }, { "sim":50.0, "partner":"5j78" @@ -356221,15 +357431,15 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"6edz" }, { "sim":50.0, - "partner":"6edz" + "partner":"6ee1" }, { "sim":50.0, - "partner":"6ee1" + "partner":"6edw" }, { "sim":50.0, @@ -356241,35 +357451,35 @@ }, { "sim":50.0, - "partner":"3ahc" + "partner":"3ahf" }, { "sim":50.0, - "partner":"3ahd" + "partner":"3ahg" }, { "sim":50.0, - "partner":"3ahe" + "partner":"3ahh" }, { "sim":50.0, - "partner":"3ahf" + "partner":"3ahi" }, { "sim":50.0, - "partner":"3ahg" + "partner":"3ahj" }, { "sim":50.0, - "partner":"3ahh" + "partner":"3ahc" }, { "sim":50.0, - "partner":"3ahi" + "partner":"3ahd" }, { "sim":50.0, - "partner":"3ahj" + "partner":"3ahe" }, { "sim":50.0, @@ -356292,7 +357502,7 @@ }, "seq_max_sim_natural":{ "sim":59.0, - "partner":"3c1y" + "partner":"3c1z" }, "struct_max_sim_designed":{ "sim":0.7371000051, @@ -356435,118 +357645,118 @@ ], "subtitle":"Bg505 sosip reconstructed from a designed tetrahedral nanoparticle, bg505 sosip-t33_dn2", "tags":[ - "nanoparticles", - "vaccine design", - "de novo protein", "de novo", + "de novo protein", + "vaccine design", + "nanoparticles", "hiv env" ], "keywords":[ - "rationale", - "many", - "ln", - "hypermutation", - "must", - "complexes", - "imaging", - "suggest", - "administered", - "pattern", "trimer", - "hiv", - "immune", - "proliferate", - "postimmunization", - "envelope", - "immunization", + "persisted", + "responses", + "zone", "show", - "findings", - "enhanced", - "display", - "specialized", - "acquire", - "nascent", - "however", - "develop", - "concentrate", - "availability", - "seven", - "strategies", - "cell", - "process", - "nanoparticles", - "dramatically", - "days", + "complexes", + "single", + "pattern", + "concentrated", + "free", "localization", + "via", + "within", + "new", "follicles", - "draining", + "somatic", "drive", - "centers", - "gcs", - "recombinant", - "rhesus", - "showed", - "revealed", - "concentrated", - "immunodeficiency", - "accumulated", - "form", - "free", "strikingly", - "germinal", - "impact", - "responses", - "lymph", + "protein", + "hiv", "following", - "virus", - "via", - "multivalent", - "antigens", - "whole", - "antigen", - "antibody", + "follicular", "vaccination", - "helper", - "trimers", - "diffuse", - "500", - "lns", - "employing", + "showed", + "accumulate", "collected", - "provides", - "observed", - "zone", - "env", - "soluble", - "using", - "present", - "formation", + "b", + "centers", "cells", - "dendritic", - "macaques", - "important", + "demonstrate", + "tissues", + "two", + "envelope", + "using", + "diffuse", + "rationale", "node", + "however", + "immunogens", + "ln", + "soluble", + "immunodeficiency", + "concentrate", + "nascent", + "lns", + "immunization", + "recombinant", + "trimers", + "rhesus", + "administered", + "postimmunization", + "draining", "sites", - "demonstrate", + "develop", + "process", "lymphoid", - "efficiently", + "multivalent", + "proliferate", + "suggest", "undergo", - "immunogens", - "somatic", - "single", - "human", - "two", - "tissues", - "ics", + "days", + "accumulated", + "enhanced", + "must", + "provides", + "nanoparticles", + "display", + "gcs", + "virus", + "immune", + "cell", "light", - "b", - "protein", - "follicular", - "within", - "accumulate", - "persisted", + "formation", + "employing", + "present", + "whole", + "env", + "form", + "revealed", + "many", + "strategies", + "ics", + "lymph", + "observed", "traditional", - "new" + "acquire", + "imaging", + "efficiently", + "important", + "antigens", + "antigen", + "specialized", + "availability", + "germinal", + "findings", + "impact", + "helper", + "dramatically", + "seven", + "macaques", + "500", + "human", + "hypermutation", + "dendritic", + "antibody" ], "release_date":"2020-08-12", "publication":"\"Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations\", NPJ Vaccines, 5, 72-72", @@ -356557,7 +357767,7 @@ "ISSN":"2059-0105", "ASTM":"" }, - "publication_country":"", + "publication_country":"UK", "abstract":"Following immunization, high-affinity antibody responses develop within germinal centers (GCs), specialized sites within follicles of the lymph node (LN) where B cells proliferate and undergo somatic hypermutation. Antigen availability within GCs is important, as B cells must acquire and present antigen to follicular helper T cells to drive this process. However, recombinant protein immunogens such as soluble human immunodeficiency virus (HIV) envelope (Env) trimers do not efficiently accumulate in follicles following traditional immunization. Here, we demonstrate two strategies to concentrate HIV Env immunogens in follicles, via the formation of immune complexes (ICs) or by employing self-assembling protein nanoparticles for multivalent display of Env antigens. Using rhesus macaques, we show that within a few days following immunization, free trimers were present in a diffuse pattern in draining LNs, while trimer ICs and Env nanoparticles accumulated in B cell follicles. Whole LN imaging strikingly revealed that ICs and trimer nanoparticles concentrated in as many as 500 follicles in a single LN within two days after immunization. Imaging of LNs collected seven days postimmunization showed that Env nanoparticles persisted on follicular dendritic cells in the light zone of nascent GCs. These findings suggest that the form of antigen administered in vaccination can dramatically impact localization in lymphoid tissues and provides a new rationale for the enhanced immune responses observed following immunization with ICs or nanoparticles.", "crystal_structure":{ "length_a":"", @@ -356595,13 +357805,97 @@ } ], "seq_thr_sim_natural":[ + { + "sim":923.0, + "partner":"9ayv" + }, { "sim":1049.0, "partner":"6p6f" }, { - "sim":1038.0, - "partner":"6pw6" + "sim":943.0, + "partner":"6nf5" + }, + { + "sim":975.0, + "partner":"6dfg" + }, + { + "sim":943.0, + "partner":"6nfc" + }, + { + "sim":963.0, + "partner":"6mar" + }, + { + "sim":953.0, + "partner":"6udk" + }, + { + "sim":957.0, + "partner":"5t3s" + }, + { + "sim":953.0, + "partner":"6oro" + }, + { + "sim":953.0, + "partner":"6orp" + }, + { + "sim":953.0, + "partner":"6orn" + }, + { + "sim":735.0, + "partner":"6um6" + }, + { + "sim":735.0, + "partner":"6um7" + }, + { + "sim":967.0, + "partner":"5u1f" + }, + { + "sim":743.0, + "partner":"6vy2" + }, + { + "sim":730.0, + "partner":"6uda" + }, + { + "sim":712.0, + "partner":"6myy" + }, + { + "sim":712.0, + "partner":"6mzj" + }, + { + "sim":1060.0, + "partner":"9axd" + }, + { + "sim":1060.0, + "partner":"9ays" + }, + { + "sim":1060.0, + "partner":"9ay6" + }, + { + "sim":948.0, + "partner":"6dfh" + }, + { + "sim":953.0, + "partner":"6orq" }, { "sim":995.0, @@ -356623,29 +357917,105 @@ "sim":982.0, "partner":"6v0r" }, + { + "sim":1038.0, + "partner":"6pw6" + }, + { + "sim":968.0, + "partner":"6u0n" + }, + { + "sim":972.0, + "partner":"6u0l" + }, { "sim":979.0, "partner":"6vn0" }, { - "sim":975.0, - "partner":"6dfg" + "sim":972.0, + "partner":"5t3z" }, { - "sim":974.0, - "partner":"5c7k" + "sim":972.0, + "partner":"5v8m" + }, + { + "sim":969.0, + "partner":"6mu6" }, { "sim":972.0, - "partner":"6ozc" + "partner":"5u7m" + }, + { + "sim":960.0, + "partner":"6de7" + }, + { + "sim":969.0, + "partner":"6nnj" + }, + { + "sim":966.0, + "partner":"6osy" + }, + { + "sim":959.0, + "partner":"6w03" + }, + { + "sim":971.0, + "partner":"5aco" + }, + { + "sim":968.0, + "partner":"6udj" + }, + { + "sim":969.0, + "partner":"6mtn" + }, + { + "sim":969.0, + "partner":"6mu7" }, { "sim":972.0, - "partner":"4nco" + "partner":"5thr" + }, + { + "sim":958.0, + "partner":"5uty" + }, + { + "sim":967.0, + "partner":"5cez" + }, + { + "sim":967.0, + "partner":"6nf2" + }, + { + "sim":968.0, + "partner":"5cjx" + }, + { + "sim":974.0, + "partner":"5c7k" + }, + { + "sim":934.0, + "partner":"5w6d" + }, + { + "sim":967.0, + "partner":"6crq" }, { "sim":972.0, - "partner":"3j5m" + "partner":"6did" }, { "sim":972.0, @@ -356653,67 +358023,91 @@ }, { "sim":972.0, - "partner":"6cm3" + "partner":"4zmj" }, { - "sim":972.0, - "partner":"4tvp" + "sim":969.0, + "partner":"6mu8" }, { "sim":972.0, - "partner":"5t3x" + "partner":"5u7o" }, { "sim":972.0, - "partner":"5fyl" + "partner":"5v8l" }, { - "sim":972.0, - "partner":"5vj6" + "sim":969.0, + "partner":"6nnf" }, { "sim":972.0, - 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"partner":"4khx" + }, + { + "sim":56.0, + "partner":"3g7a" + }, + { + "sim":56.0, + "partner":"5yb3" + }, + { + "sim":56.0, + "partner":"5z0w" + }, + { + "sim":56.0, + "partner":"5yb4" + }, + { + "sim":56.0, + "partner":"3vie" + }, + { + "sim":56.0, + "partner":"6jqk" + }, + { + "sim":56.0, + "partner":"3f4y" + }, + { + "sim":56.0, + "partner":"3f50" + }, + { + "sim":56.0, + "partner":"3o3z" + }, + { + "sim":56.0, + "partner":"3vtq" + }, + { + "sim":55.0, + "partner":"3aha" + }, + { + "sim":53.0, + "partner":"3u91" + }, + { + "sim":53.0, + "partner":"2z2t" + }, + { + "sim":52.0, + "partner":"4hlr" + }, + { + "sim":52.0, + "partner":"5zpw" + }, + { + "sim":52.0, + "partner":"2ari" + }, + { + "sim":52.0, + "partner":"3p7k" + }, + { + "sim":52.0, + "partner":"5c0r" + }, + { + "sim":51.0, + "partner":"5c0s" + }, + { + "sim":972.0, + "partner":"4nco" + }, + { + "sim":972.0, + "partner":"3j5m" + }, + { + "sim":918.0, + "partner":"3jcb" + }, + { + "sim":918.0, + "partner":"3jcc" + }, + { + "sim":734.0, + "partner":"6met" + }, + { + "sim":734.0, + "partner":"6meo" + }, + { + "sim":722.0, + "partner":"3j70" }, { "sim":616.0, @@ -357137,11 +358739,11 @@ }, { "sim":577.0, - "partner":"6mg7" + "partner":"5w4l" }, { "sim":577.0, - "partner":"5w4l" + "partner":"6mg7" }, { "sim":576.0, @@ -357159,10 +358761,6 @@ "sim":566.0, "partner":"4lss" }, - { - "sim":564.0, - "partner":"6ohy" - }, { "sim":562.0, "partner":"4xvs" @@ -357247,10 +358845,6 @@ "sim":533.0, "partner":"6ofi" }, - { - "sim":533.0, - "partner":"3tgr" - }, { "sim":533.0, "partner":"3tgs" @@ -357263,6 +358857,10 @@ "sim":533.0, "partner":"4lsv" }, + { + "sim":533.0, + "partner":"3tgr" + }, { "sim":533.0, "partner":"3rjq" @@ -357271,14 +358869,6 @@ "sim":531.0, "partner":"5te7" }, - { - "sim":529.0, - "partner":"4rfo" - }, - { - "sim":529.0, - "partner":"6w4m" - }, { "sim":529.0, "partner":"4dko" @@ -357356,20 +358946,12 @@ "partner":"6bck" }, { - "sim":527.0, - "partner":"3se9" - }, - { - "sim":527.0, - "partner":"4ydl" - }, - { - "sim":527.0, - "partner":"4jb9" + "sim":529.0, + "partner":"4rfo" }, { - "sim":527.0, - "partner":"4olx" + "sim":529.0, + "partner":"6w4m" }, { "sim":527.0, @@ -357467,6 +359049,22 @@ "sim":527.0, "partner":"4olw" }, + { + "sim":527.0, + "partner":"3se9" + }, + { + "sim":527.0, + "partner":"4ydl" + }, + { + "sim":527.0, + "partner":"4jb9" + }, + { + "sim":527.0, + "partner":"4olx" + }, { "sim":527.0, "partner":"3u7y" @@ -357529,11 +359127,11 @@ }, { "sim":517.0, - "partner":"4lst" + "partner":"4jan" }, { "sim":517.0, - "partner":"4jan" + "partner":"4lst" }, { "sim":516.0, @@ -357615,14 +359213,6 @@ "sim":474.0, "partner":"2ny1" }, - { - "sim":471.0, - "partner":"1yyl" - }, - { - "sim":471.0, - "partner":"4rqs" - }, { "sim":471.0, "partner":"5a8h" @@ -357641,11 +359231,11 @@ }, { "sim":471.0, - "partner":"1g9n" + "partner":"2i5y" }, { "sim":471.0, - "partner":"2i5y" + "partner":"1g9n" }, { "sim":471.0, @@ -357655,6 +359245,14 @@ "sim":471.0, "partner":"1rzk" }, + { + "sim":471.0, + "partner":"1yyl" + }, + { + "sim":471.0, + "partner":"4rqs" + }, { "sim":471.0, "partner":"2ny3" @@ -357741,11 +359339,11 @@ }, { "sim":153.0, - "partner":"2bf1" + "partner":"3fus" }, { "sim":153.0, - "partner":"3fus" + "partner":"2bf1" }, { "sim":151.0, @@ -357799,6 +359397,10 @@ "sim":70.0, "partner":"5vgj" }, + { + "sim":70.0, + "partner":"8zni" + }, { "sim":68.0, "partner":"1ce4" @@ -357822,366 +359424,6 @@ { "sim":51.0, "partner":"6cbp" - }, - { - "sim":129.0, - "partner":"3p30" - }, - { - "sim":128.0, - "partner":"1env" - }, - { - "sim":106.0, - "partner":"1qbz" - }, - { - "sim":106.0, - "partner":"2ezo" - }, - { - "sim":106.0, - "partner":"2ezp" - }, - { - "sim":106.0, - "partner":"2ezq" - }, - { - "sim":106.0, - "partner":"2ezr" - }, - { - "sim":106.0, - "partner":"2ezs" - }, - { - "sim":106.0, - "partner":"1qce" - }, - { - "sim":102.0, - "partner":"3cp1" - }, - { - "sim":102.0, - "partner":"3mac" - }, - { - "sim":102.0, - "partner":"3ma9" - }, - { - 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"postimmunization", - "envelope", - "immunization", + "persisted", + "responses", + "zone", "show", - "findings", - "enhanced", - "display", - "specialized", - "acquire", - "nascent", - "however", - "develop", - "concentrate", - "availability", - "seven", - "strategies", - "cell", - "process", - "nanoparticles", - "dramatically", - "days", + "complexes", + "single", + "pattern", + "concentrated", + "free", "localization", + "via", + "within", + "new", "follicles", - "draining", + "somatic", "drive", - "centers", - "gcs", - "recombinant", - "rhesus", - "showed", - "revealed", - "concentrated", - "immunodeficiency", - "accumulated", - "form", - "free", "strikingly", - "germinal", - "impact", - "responses", - "lymph", + "protein", + "hiv", "following", - "virus", - "via", - "multivalent", - "antigens", - "whole", - "antigen", - "antibody", + "follicular", "vaccination", - "helper", - "trimers", - "diffuse", - "500", - "lns", - "employing", + "showed", + "accumulate", "collected", - "provides", - "observed", - "zone", - "env", - "soluble", - "using", - "present", - "formation", + "b", + "centers", "cells", - "dendritic", - "macaques", - "important", + "demonstrate", + "tissues", + "two", + "envelope", + "using", + "diffuse", + "rationale", "node", + "however", + "immunogens", + "ln", + "soluble", + "immunodeficiency", + "concentrate", + "nascent", + "lns", + "immunization", + "recombinant", + "trimers", + "rhesus", + "administered", + "postimmunization", + "draining", "sites", - "demonstrate", + "develop", + "process", "lymphoid", - "efficiently", + "multivalent", + "proliferate", + "suggest", "undergo", - "immunogens", - "somatic", - "single", - "human", - "two", - "tissues", - "ics", + "days", + "accumulated", + "enhanced", + "must", + "provides", + "nanoparticles", + "display", + "gcs", + "virus", + "immune", + "cell", "light", - "b", - "protein", - "follicular", - "within", - "accumulate", - "persisted", + "formation", + "employing", + "present", + "whole", + "env", + "form", + "revealed", + "many", + "strategies", + "ics", + "lymph", + "observed", "traditional", - "new" + "acquire", + "imaging", + "efficiently", + "important", + "antigens", + "antigen", + "specialized", + "availability", + "germinal", + "findings", + "impact", + "helper", + "dramatically", + "seven", + "macaques", + "500", + "human", + "hypermutation", + "dendritic", + "antibody" ], "release_date":"2020-08-12", "publication":"\"Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations\", NPJ Vaccines, 5, 72-72", @@ -358511,11 +359753,11 @@ }, { "sim":169.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":169.0, - "partner":"8cqq" + "partner":"8cqp" }, { "sim":169.0, @@ -358523,27 +359765,27 @@ }, { "sim":169.0, - "partner":"8chy" + "partner":"8cmq" }, { "sim":169.0, - "partner":"8cmq" + "partner":"8bu0" }, { "sim":169.0, - "partner":"8ckr" + "partner":"8cp8" }, { "sim":169.0, - "partner":"8cig" + "partner":"8cqq" }, { "sim":169.0, - "partner":"8cqp" + "partner":"8chy" }, { "sim":169.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":168.0, @@ -358551,11 +359793,11 @@ }, { "sim":167.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":167.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":169.0, @@ -358567,15 +359809,15 @@ }, { "sim":79.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":79.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":79.0, - "partner":"8cus" + "partner":"8cwz" } ], "seq_thr_sim_natural":[ @@ -358705,135 +359947,135 @@ ], "subtitle":"Structure of a covalently captured collagen triple helix using lysine-glutamate pairs", "tags":[ - "triple helix", "isopeptide bond", "collagen mimetic peptide", + "triple helix", "biosynthetic protein" ], "keywords":[ - "thermal", - "improve", - "use", - "bonds", - "cmps", - "including", - "allowing", - "triple", - "register", - "enhance", - "cmp", - "crystal", - "assembled", - "interactions", - "conformation", - "enhanced", - "equilibrium", + "relatively", + "demonstrates", + "rate", + "collagen", + "structural", + "number", "therefore", - "structure", "heterotrimeric", - "faster", - "aspect", - "occurs", - "direct", - "biomedical", - "limit", - "without", - "lysine", - "excellent", - "amide", - "proteins", - "solved", + "three", + "isopeptide", + "within", + "canonical", + "folding", + "assembled", "perturbing", - "family", - "yielding", - "number", + "slower", + "reproducing", + "preservation", "mimetic", - "effectively", - "used", - "serve", - "demonstrates", - "covalently", + "helical", + "biomedical", "motif", - "collagen", - "biomaterials", - "preservation", - "complicated", - "aspartate", - "capture", - "three", - "linked", + "equilibrium", + "yielding", + "demonstrate", + "register", + "covalently", "circular", + "two", + "applications", + "crystal", + "helices", + "captured", "either", - "compared", - "first", - "stability", - "covalent", + "supramolecular", + "complex", + "reaction", + "conformation", + "improve", + "problems", + "enhance", + "confirming", + "lysine", + "formed", + "purposes", + "aspartate", + "biological", + "helix", + "family", + "factors", + "capture", + "thermal", "control", - "demonstrated", - "amino", - "additionally", + "stability", + "approach", + "proteins", "large", + "use", + "bond", + "along", + "triple", + "biomaterials", "higher", - "factors", + "stabilize", + "linked", "four", - "acids", - "shown", + "allowing", + "including", "refolding", - "canonical", - "unequivocally", - "rate", - "stabilize", - "observed", - "connectivity", - "helical", - "bond", - "applications", - "competing", - "captured", - "confirming", - "biological", "increase", - "formation", - "structural", - "important", - "range", - "fixing", - "supramolecular", - "capabilities", - "demonstrate", - "poor", - "fundamental", - "reproducing", - "helices", + "direct", + "slow", + "aspect", + "enhanced", + "compared", + "used", + "possible", + "species", + "different", + "amide", + "bonds", "also", - "approach", - "composition", + "covalent", + "fixing", + "amino", "wide", + "shown", + "limit", + "formation", + "complicated", + "poor", "contrast", - "along", - "problems", + "demonstrated", + "solved", "peptides", - "species", - "different", - "reaction", - "two", - "glutamate", + "excellent", + "connectivity", + "effectively", + "capabilities", + "range", + "fundamental", + "observed", + "competing", + "first", + "without", + "important", + "structure", + "serve", "subsequently", - "hierarchy", - "slower", + "additionally", + "occurs", + "interactions", + "unequivocally", "yield", - "purposes", - "complex", - "helix", - "relatively", "understanding", - "within", + "cmps", + "hierarchy", + "faster", "dichroism", - "folding", - "possible", - "slow", - "formed", - "isopeptide" + "cmp", + "acids", + "glutamate", + "composition" ], "release_date":"2020-09-02", "publication":"\"Covalent Capture of Collagen Triple Helices Using Lysine-Aspartate and Lysine-Glutamate Pairs\", Biomacromolecules, 21, 3772-3781", @@ -358957,97 +360199,97 @@ "ntf2" ], "keywords":[ - "repurposing", - "systematically", - "challenge", - "assessment", - "temperatures", - "geometries", - "shapes", - "crystal", + "genes", + "yeast", "limited", - "synthetic", - "precise", - "generates", - "designing", - "structure", - "diversity", - "algorithm", - "5", - "proteins", - "testing", - "challenges", - "remain", - "cell", - "de", - "enzymes", - "outstanding", - "superfamily", + "structural", "number", - "64", - "remains", + "experimental", + "outstanding", + "biosensors", + "new", + "model", + "protein", + "5", + "binding", "site", + "novo", + "encoding", + "two", + "precise", + "crystal", + "total", + "temperatures", + "assessment", + "optimal", + "using", + "enumerative", "occurring", - "sensors", - "folded", - "feedback", - "structures", - "naturally", - "transform", - "assembly", - "exhibit", - "much", - "rounds", - "stability", - "control", - "unlimited", + "creating", + "creation", "involving", - "detailed", - "expect", - "active", - "optimal", + "enabling", + "accessible", "specific", - "biosensors", - "model", - "design", + "control", + "folded", + "stability", + "approach", + "sites", + "proteins", + "rounds", "characterization", - "using", - "scratch", + "enzymes", + "shapes", + "repurposing", + "importance", + "supporting", + "geometries", "surface", - "high", - "genes", - "virtually", - "total", - "structural", - "enabling", - "sites", + "designing", + "pocket", + "exhibit", + "design", + "transform", "diverse", - "designs", - "importance", - "encoding", + "active", + "testing", + "virtually", "tested", - "paramount", - "accessible", - "approach", - "novo", + "assembly", "sizes", - "experimental", - "two", + "diversity", + "cell", + "superfamily", + "generates", + "algorithm", "system", - "creating", - "enumerative", - "creation", - "protein", + "developed", "refined", + "scratch", + "64", + "naturally", + "unlimited", + "structures", + "de", + "feedback", + "detailed", + "remains", + "structure", + "synthetic", + "challenges", + "biophysical", + "expect", + "paramount", + "high", + "much", + "remain", + "sensors", "arbitrary", - "yeast", - "pocket", - "binding", - "developed", "create", - "biophysical", - "supporting", - "new" + "challenge", + "designs", + "systematically" ], "release_date":"2020-04-08", "publication":"\"An enumerative algorithm for de novo design of proteins with diverse pocket structures\", Proc.Natl.Acad.Sci.USA, 117, 22135-22145", @@ -359177,97 +360419,97 @@ "ntf2" ], "keywords":[ - "repurposing", - "systematically", - "challenge", - "assessment", - "temperatures", - "geometries", - "shapes", - "crystal", + "genes", + "yeast", "limited", - "synthetic", - "precise", - "generates", - "designing", - "structure", - "diversity", - "algorithm", - "5", - "proteins", - "testing", - "challenges", - "remain", - "cell", - "de", - "enzymes", - "outstanding", - "superfamily", + "structural", "number", - "64", - "remains", + "experimental", + "outstanding", + "biosensors", + "new", + "model", + "protein", + "5", + "binding", "site", + "novo", + "encoding", + "two", + "precise", + "crystal", + "total", + "temperatures", + "assessment", + "optimal", + "using", + "enumerative", "occurring", - "sensors", - "folded", - "feedback", - "structures", - "naturally", - "transform", - "assembly", - "exhibit", - "much", - "rounds", - "stability", - "control", - "unlimited", + "creating", + "creation", "involving", - "detailed", - "expect", - "active", - "optimal", + "enabling", + "accessible", "specific", - "biosensors", - "model", - "design", + "control", + "folded", + "stability", + "approach", + "sites", + "proteins", + "rounds", "characterization", - "using", - "scratch", + "enzymes", + "shapes", + "repurposing", + "importance", + "supporting", + "geometries", "surface", - "high", - "genes", - "virtually", - "total", - "structural", - "enabling", - "sites", + "designing", + "pocket", + "exhibit", + "design", + "transform", "diverse", - "designs", - "importance", - "encoding", + "active", + "testing", + "virtually", "tested", - "paramount", - "accessible", - "approach", - "novo", + "assembly", "sizes", - "experimental", - "two", + "diversity", + "cell", + "superfamily", + "generates", + "algorithm", "system", - "creating", - "enumerative", - "creation", - "protein", + "developed", "refined", + "scratch", + "64", + "naturally", + "unlimited", + "structures", + "de", + "feedback", + "detailed", + "remains", + "structure", + "synthetic", + "challenges", + "biophysical", + "expect", + "paramount", + "high", + "much", + "remain", + "sensors", "arbitrary", - "yeast", - "pocket", - "binding", - "developed", "create", - "biophysical", - "supporting", - "new" + "challenge", + "designs", + "systematically" ], "release_date":"2020-04-08", "publication":"\"An enumerative algorithm for de novo design of proteins with diverse pocket structures\", Proc.Natl.Acad.Sci.USA, 117, 22135-22145", @@ -359375,101 +360617,101 @@ ], "subtitle":"Valine-containing collagen peptide", "tags":[ - "collagen", - "triple helix", "cmp", + "biosynthetic protein", "structural protein", - "biosynthetic protein" + "collagen", + "triple helix" ], "keywords":[ - "results", - "proximal", - "xaa", - "multiple", + "limited", "delicate", + "collagen", + "accounting", + "modulated", + "multiple", + "varied", "acid", - "including", - "time", - "peptide", - "triple", - "provide", - "crystal", - "limited", - "sequences", - "position", - "interactions", - "repeating", - "structure", - "conjunction", - "primary", + "canonical", + "polypeptide", + "results", + "new", + "residue", + "insight", "network", - "detail", - "although", - "propensities", - "compare", - "balance", - "collagen", - "preserving", - "bonding", - "highlight", - "structures", - "buried", + "study", "positions", - "atomic", + "azgly", + "two", + "crystal", "effects", - "yaa", - "first", + "helices", "rules", + "adjacent", + "using", "stereoelectronic", - "hydrogen", - "solvent", - "impact", + "preserving", + "residues", + "specific", + "helix", + "level", + "although", + "buried", "stability", - "data", - "interfacial", - "amino", + "described", "protecting", - "geometry", - "acids", - "gain", - "specific", - "canonical", - "accounting", - "design", - "polypeptide", - "modulated", + "hydrogen", "bond", - "using", - "present", - "azgly", + "balance", + "triple", + "computational", "importance", + "including", + "peptide", + "set", + "bonding", + "highlight", + "design", "critical", - "fundamental", "subtle", - "helices", - "study", - "described", - "insight", - "peptides", + "atomic", "different", - "residues", - "dispersive", - "adjacent", - "two", - "guidelines", - "varied", + "compare", + "amino", "incorporating", - "set", - "variation", - "residue", + "propensities", + "primary", "backbone", - "helix", - "extend", - "understanding", - "computational", + "interfacial", + "time", + "peptides", + "present", + "yaa", + "fundamental", + "xaa", + "sequences", + "repeating", + "geometry", + "structures", + "first", + "proximal", + "structure", + "provide", + "interactions", + "impact", "biophysical", - "level", - "new" + "guidelines", + "understanding", + "detail", + "conjunction", + "gain", + "extend", + "acids", + "dispersive", + "solvent", + "position", + "data", + "variation" ], "release_date":"2020-08-12", "publication":"\"Rules for the design of aza-glycine stabilized triple-helical collagen peptides\", Chem Sci, 11, 10638-10646", @@ -359571,102 +360813,102 @@ ], "subtitle":"Peptoid-containing collagen peptide", "tags":[ - "peptoid", - "collagen", - "triple helix", "cmp", + "biosynthetic protein", "structural protein", - "biosynthetic protein" + "collagen", + "triple helix", + "peptoid" ], "keywords":[ - "results", - "proximal", - "xaa", - "multiple", + "limited", "delicate", + "collagen", + "accounting", + "modulated", + "multiple", + "varied", "acid", - "including", - "time", - "peptide", - "triple", - "provide", - "crystal", - "limited", - "sequences", - "position", - "interactions", - "repeating", - "structure", - "conjunction", - "primary", + "canonical", + "polypeptide", + "results", + "new", + "residue", + "insight", "network", - "detail", - "although", - "propensities", - "compare", - "balance", - "collagen", - "preserving", - "bonding", - "highlight", - "structures", - "buried", + "study", "positions", - "atomic", + "azgly", + "two", + "crystal", "effects", - "yaa", - "first", + "helices", "rules", + "adjacent", + "using", "stereoelectronic", - "hydrogen", - "solvent", - "impact", + "preserving", + "residues", + "specific", + "helix", + "level", + "although", + "buried", "stability", - "data", - "interfacial", - "amino", + "described", "protecting", - "geometry", - "acids", - "gain", - "specific", - "canonical", - "accounting", - "design", - "polypeptide", - "modulated", + "hydrogen", "bond", - "using", - "present", - "azgly", + "balance", + "triple", + "computational", "importance", + "including", + "peptide", + "set", + "bonding", + "highlight", + "design", "critical", - "fundamental", "subtle", - "helices", - "study", - "described", - "insight", - "peptides", + "atomic", "different", - "residues", - "dispersive", - "adjacent", - "two", - "guidelines", - "varied", + "compare", + "amino", "incorporating", - "set", - "variation", - "residue", + "propensities", + "primary", "backbone", - "helix", - "extend", - "understanding", - "computational", + "interfacial", + "time", + "peptides", + "present", + "yaa", + "fundamental", + "xaa", + "sequences", + "repeating", + "geometry", + "structures", + "first", + "proximal", + "structure", + "provide", + "interactions", + "impact", "biophysical", - "level", - "new" + "guidelines", + "understanding", + "detail", + "conjunction", + "gain", + "extend", + "acids", + "dispersive", + "solvent", + "position", + "data", + "variation" ], "release_date":"2020-08-12", "publication":"\"Rules for the design of aza-glycine stabilized triple-helical collagen peptides\", Chem Sci, 11, 10638-10646", @@ -359757,71 +360999,71 @@ ], "subtitle":"Crystal structure of able apo-protein", "tags":[ - "4-helix bundle", "de novo protein", + "ligand-binding", "de novo", - "ligand-binding" + "4-helix bundle" ], "keywords":[ - "great", - "functional", - "amino", - "proteins", - "represents", - "groups", - "chemical", - "der", - "low", - "de", - "novo", - "challenge", - "acid", - "drug", - "crystallography", - "medicine", - "preferred", + "affinity", "designed", - "enable", - "may", - "statistically", + "complex", + "mutagenesis", + "design", "interacting", - "functionalized", - "small", - "highly", - "confirmed", - "vdms", "binders", - "mer", - "two", + "preferred", + "statistically", + "cavity", + "de", + "functional", + "represents", + "medicine", + "vdm", + "structure", + "great", + "acid", + "groups", "precisely", + "crystallography", + "interactions", + "protein", + "maps", "six", - "unit", - "apixaban", - "cavity", - "design", - "sensing", "bind", - "protein", + "amino", "positions", - "using", + "drug", + "unit", + "proteins", "bound", - "submicromolar", + "low", + "molecules", + "enable", + "mer", "backbone", - "interactions", - "complex", + "vdms", + "confirmed", "van", + "novo", + "may", + "sensing", + "highly", + "small", + "forms", + "der", + "favorable", + "two", + "developed", "applications", - "vdm", - "maps", - "structure", + "chemical", + "challenge", "computational", - "favorable", - "affinity", - "molecules", + "using", "catalysis", - "developed", - "forms", - "mutagenesis" + "functionalized", + "apixaban", + "submicromolar" ], "release_date":"2020-08-26", "publication":"\"A defined structural unit enables de novo design of small-molecule-binding proteins\", Science, 369, 1227-1233", @@ -359922,71 +361164,71 @@ ], "subtitle":"Crystal structure of apixaban-bound able", "tags":[ - "4-helix bundle", "de novo protein", + "ligand-binding", "de novo", - "ligand-binding" + "4-helix bundle" ], "keywords":[ - "great", - "functional", - "amino", - "proteins", - "represents", - "groups", - "chemical", - "der", - "low", - "de", - "novo", - "challenge", - "acid", - "drug", - "crystallography", - "medicine", - "preferred", + "affinity", "designed", - "enable", - "may", - "statistically", + "complex", + "mutagenesis", + "design", "interacting", - "functionalized", - "small", - "highly", - "confirmed", - "vdms", "binders", - "mer", - "two", + "preferred", + "statistically", + "cavity", + "de", + "functional", + "represents", + "medicine", + "vdm", + "structure", + "great", + "acid", + "groups", "precisely", + "crystallography", + "interactions", + "protein", + "maps", "six", - "unit", - "apixaban", - "cavity", - "design", - "sensing", "bind", - "protein", + "amino", "positions", - "using", + "drug", + "unit", + "proteins", "bound", - "submicromolar", + "low", + "molecules", + "enable", + "mer", "backbone", - "interactions", - "complex", + "vdms", + "confirmed", "van", + "novo", + "may", + "sensing", + "highly", + "small", + "forms", + "der", + "favorable", + "two", + "developed", "applications", - "vdm", - "maps", - "structure", + "chemical", + "challenge", "computational", - "favorable", - "affinity", - "molecules", + "using", "catalysis", - "developed", - "forms", - "mutagenesis" + "functionalized", + "apixaban", + "submicromolar" ], "release_date":"2020-08-26", "publication":"\"A defined structural unit enables de novo design of small-molecule-binding proteins\", Science, 369, 1227-1233", @@ -360106,85 +361348,85 @@ ], "subtitle":"De novo designed ntf2 fold protein nt-9", "tags":[ - "geometric sampling", "de novo fold family", - "loop-helix-loop motif", "de novo protein", + "geometric sampling", + "loop-helix-loop motif", "protein design" ], "keywords":[ + "geometries", + "designed", + "lucs", + "designing", + "offers", + "naturally", + "design", + "sampling", + "space", + "structural", + "17", "diverse", - "designs", - "mimics", + "encompassing", + "structures", + "well", + "expands", + "families", + "experimentally", + "different", "overall", "tested", - "proteins", - "solved", - "greatly", - "combinatorial", - "families", - "also", - "four", - "elements", - "topologies", - "matched", + "16", + "structure", "fold", - "including", - "method", - "designed", - "geometries", - "well", - "may", - "different", - "expands", - "highly", - "encompassing", - "shapes", - "lucs", - "found", - "optimal", - "vary", + "elements", + "novel", + "new", + "also", + "closely", "precisely", - "two", + "functions", + "matched", + "designable", "nature", - "experimentally", - "closely", - "occurring", - "unit", - "ability", + "biophysical", + "topologies", + "vary", + "function", "folded", - "functions", + "known", + "unit", + "proteins", "38", - "design", - "sampling", - "characterization", - "structures", - "naturally", - "precise", - "surpassing", + "customizable", + "mimics", "generates", - "present", - "45", - "offers", - "paradigm", - "space", - "designing", - "structure", - "function", + "characterization", "showed", - "17", - "16", - "distinct", - "computational", - "designable", + "greatly", + "ability", + "may", + "shapes", + "45", + "combinatorial", + "highly", "tunable", - "known", - "novel", - "structural", + "distinct", + "solved", + "found", + "surpassing", + "two", + "present", + "precise", + "four", "create", - "biophysical", - "new", - "customizable" + "optimal", + "method", + "designs", + "computational", + "including", + "paradigm", + "occurring" ], "release_date":"2020-08-19", "publication":"\"Expanding the space of protein geometries by computational design of de novo fold families\", Science, 369, 1132-1136", @@ -360370,82 +361612,82 @@ "de novo design" ], "keywords":[ - "built", - "control", - "makes", - "posttranscriptional", + "designed", + "cooperativity", + "normal", "largely", - "logic", - "unlimited", - "sophisticated", - "regulate", - "proteins", - "gene", - "components", - "cell", + "form", "enables", - "approach", + "ready", + "yeast", + "coupled", + "design", "essentially", + "stoichiometric", + "posttranscriptional", + "tim3", + "posttranslational", + "association", + "number", + "extension", + "unlimited", + "built", "de", "ranging", - "enzymes", - "novo", + "biology", "wide", - "challenge", - "insensitive", - "inputs", + "machinery", + "gene", + "biological", + "synthetic", + "level", "elements", - "human", - "disjunctive", - "cooperativity", - "xnor", - "designed", - "modular", - "number", - "enable", - "confirmed", - "exhaustion", - "range", "functions", - "stoichiometric", - "extension", + "imbalances", + "control", + "protein", + "cell", + "makes", + "function", + "xnor", "transcriptional", + "mass", + "approach", + "proteins", "vitro", - "posttranslational", - "ability", + "exhaustion", + "binding", + "inputs", + "disjunctive", + "interaction", + "logic", "modularity", - "design", - "units", - "expression", - "normal", - "protein", - "synthetic", - "gates", + "primary", + "enable", + "modular", "nand", - "spectrometry", + "units", + "enzymes", + "cells", + "confirmed", + "native", + "ability", + "novo", "split", - "association", + "sophisticated", + "components", + "expression", + "related", + "arbitrary", "describe", + "range", "regulating", - "function", - "arbitrary", - "native", - "biology", - "tim3", - "biological", - "form", - "mass", - "yeast", - "machinery", - "primary", - "cells", - "imbalances", - "coupled", - "ready", - "binding", - "related", - "level", - "interaction" + "challenge", + "gates", + "human", + "spectrometry", + "insensitive", + "regulate" ], "release_date":"2020-04-22", "publication":"\"De novo design of protein logic gates\", Science, 368, 78-84", @@ -360569,79 +361811,79 @@ ], "subtitle":"Cryo-em of form 1 related peptide filament, 29-24-3", "tags":[ - "filament", "self-assembly peptide filament", "protein fibril", - "cryo-em" + "cryo-em", + "filament" ], "keywords":[ - "seven", - "interfaces", - "analysis", + "designed", "supramolecular", - "resultant", "robustly", - "challenges", - "architecture", + "analysis", + "symmetry", + "design", + "controlled", + "dimensions", + "however", + "interfaces", + "structural", "filaments", - "assemblies", - "approach", - "similar", - "de", - "novo", - "designability", - "rational", "resolution", - "arginine", - "interaction", - "lateral", - "correlations", - "protofilaments", "length", - "peptide", - "filamentous", - "insight", - "flagella", - "designed", - "controlled", - "residues", - "dimensions", - "provide", - "motif", - "exquisite", - "provides", - "lability", "observed", + "provides", + "de", + "correlations", + "rational", + "clasp", "based", - "design", - "controlling", - "helical", - "significant", - "protein", + "residues", + "structure", "synthetic", + "lability", + "challenges", + "within", + "provide", + "nanotubes", + "quaternary", + "insight", "interactions", + "protein", + "designability", + "controlling", + "approach", + "pili", + "helical", + "motif", + "interaction", + "mediate", "generates", - "present", - "paradigm", - "symmetry", - "describe", "nanomaterials", - "structure", - "unusual", - "clasp", + "pair", + "architecture", + "novo", + "exquisite", + "arginine", "sequence", + "plasticity", + "seven", + "filamentous", + "lateral", "subunits", - "pili", - "within", "cohesive", - "mediate", + "present", + "describe", + "peptide", + "assemblies", + "unusual", "identifies", - "however", - "quaternary", - "structural", - "pair", - "nanotubes", - "plasticity" + "flagella", + "similar", + "resultant", + "paradigm", + "protofilaments", + "significant" ], "release_date":"2020-12-02", "publication":"\"Structural analysis of cross alpha-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials\", Nat Commun, 12, 407-407", @@ -360766,79 +362008,79 @@ ], "subtitle":"Cryo-em of form 1 related peptide filament, 36-31-3-rd", "tags":[ - "filament", "self-assembly peptide filament", "protein fibril", - "cryo-em" + "cryo-em", + "filament" ], "keywords":[ - "seven", - "interfaces", - "analysis", + "designed", "supramolecular", - "resultant", "robustly", - "challenges", - "architecture", + "analysis", + "symmetry", + "design", + "controlled", + "dimensions", + "however", + "interfaces", + "structural", "filaments", - "assemblies", - "approach", - "similar", - "de", - "novo", - "designability", - "rational", "resolution", - "arginine", - "interaction", - "lateral", - "correlations", - "protofilaments", "length", - "peptide", - "filamentous", - "insight", - "flagella", - "designed", - "controlled", - "residues", - "dimensions", - "provide", - "motif", - "exquisite", - "provides", - "lability", "observed", + "provides", + "de", + "correlations", + "rational", + "clasp", "based", - "design", - "controlling", - "helical", - "significant", - "protein", + "residues", + "structure", "synthetic", + "lability", + "challenges", + "within", + "provide", + "nanotubes", + "quaternary", + "insight", "interactions", + "protein", + "designability", + "controlling", + "approach", + "pili", + "helical", + "motif", + "interaction", + "mediate", "generates", - "present", - "paradigm", - "symmetry", - "describe", "nanomaterials", - "structure", - "unusual", - "clasp", + "pair", + "architecture", + "novo", + "exquisite", + "arginine", "sequence", + "plasticity", + "seven", + "filamentous", + "lateral", "subunits", - "pili", - "within", "cohesive", - "mediate", + "present", + "describe", + "peptide", + "assemblies", + "unusual", "identifies", - "however", - "quaternary", - "structural", - "pair", - "nanotubes", - "plasticity" + "flagella", + "similar", + "resultant", + "paradigm", + "protofilaments", + "significant" ], "release_date":"2020-12-02", "publication":"\"Structural analysis of cross alpha-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials\", Nat Commun, 12, 407-407", @@ -360963,79 +362205,79 @@ ], "subtitle":"Cryo-em of form 1 related peptide filament, 36-31-3", "tags":[ - "filament", "self-assembly peptide filament", "protein fibril", - "cryo-em" + "cryo-em", + "filament" ], "keywords":[ - "seven", - "interfaces", - "analysis", + "designed", "supramolecular", - "resultant", "robustly", - "challenges", - "architecture", + "analysis", + "symmetry", + "design", + "controlled", + "dimensions", + "however", + "interfaces", + "structural", "filaments", - "assemblies", - "approach", - "similar", - "de", - "novo", - "designability", - "rational", "resolution", - "arginine", - "interaction", - "lateral", - "correlations", - "protofilaments", "length", - "peptide", - "filamentous", - "insight", - "flagella", - "designed", - "controlled", - "residues", - "dimensions", - "provide", - "motif", - "exquisite", - "provides", - "lability", "observed", + "provides", + "de", + "correlations", + "rational", + "clasp", "based", - "design", - "controlling", - "helical", - "significant", - "protein", + "residues", + "structure", "synthetic", + "lability", + "challenges", + "within", + "provide", + "nanotubes", + "quaternary", + "insight", "interactions", + "protein", + "designability", + "controlling", + "approach", + "pili", + "helical", + "motif", + "interaction", + "mediate", "generates", - "present", - "paradigm", - "symmetry", - "describe", "nanomaterials", - "structure", - "unusual", - "clasp", + "pair", + "architecture", + "novo", + "exquisite", + "arginine", "sequence", + "plasticity", + "seven", + "filamentous", + "lateral", "subunits", - "pili", - "within", "cohesive", - "mediate", + "present", + "describe", + "peptide", + "assemblies", + "unusual", "identifies", - "however", - "quaternary", - "structural", - "pair", - "nanotubes", - "plasticity" + "flagella", + "similar", + "resultant", + "paradigm", + "protofilaments", + "significant" ], "release_date":"2020-12-02", "publication":"\"Structural analysis of cross alpha-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials\", Nat Commun, 12, 407-407", @@ -361186,73 +362428,73 @@ "de novo design" ], "keywords":[ - "linearly", - "exchange", - "interfaces", - "reconfigure", - "general", - "demonstrate", - "designs", - "\u03b2", - "closed", - "undergo", - "models", + "asymmetric", "play", - "reversible", - "approach", - "components", + "central", + "heterodimers", + "designing", + "models", + "design", + "interfaces", + "association", "must", - "complexes", - "also", - "use", "multiprotein", - "behaved", - "stable", - "generate", - "wide", - "asymmetric", - "challenge", - "close", - "route", - "rapidly", - "rings", - "roles", - "enable", + "provides", + "soluble", + "complexes", "well", - "hub", - "isolation", + "biology", + "behaved", + "structures", + "closed", + "reconfigurable", "different", + "roles", "subunit", + "\u03b2", "mixing", - "crystal", - "heterodimers", - "six", + "route", + "rapidly", + "branched", + "also", + "reversible", + "assembled", + "cyclic", + "protein", + "implicit", + "readily", "folded", - "assemble", - "central", - "provides", - "design", + "six", + "reconfigure", + "wide", + "approach", + "linearly", + "enable", + "use", + "close", + "isolation", "arranged", - "structures", - "assembled", - "soluble", + "general", "upon", - "branched", - "present", - "reconfigurable", - "protein", + "demonstrate", "negative", + "exchange", + "components", + "systems", + "contain", + "rings", "variety", - "association", + "present", + "hub", + "crystal", + "stable", + "assemble", "construct", - "designing", - "readily", - "biology", + "challenge", + "designs", "computational", - "implicit", - "systems", - "cyclic", - "contain" + "generate", + "undergo" ], "release_date":"2021-11-10", "publication":"\"Reconfigurable asymmetric protein assemblies through implicit negative design\", Science, 375, eabj7662-eabj7662", @@ -361413,75 +362655,75 @@ ], "subtitle":"Crystal structure of computationally designed protein 3ds18 in complex with the human transferrin receptor ectodomain", "tags":[ - "de novo protein-metal transport complex", + "complex", "beta sheet", - "receptor", "de novo protein", "de novo protein\/metal transport", - "complex" + "de novo protein-metal transport complex", + "receptor" ], "keywords":[ "htfr", - "general", - "geometrically", - "k", - "delivery", - "strands", - "nm", - "groups", - "proteins", - "shuttles", - "approach", - "de", - "novo", - "edge", - "opening", - "transferrin", - "strategy", - "sheet", - "matched", - "thermodynamic", - "human", - "drug", - "barrier", - "crosses", - "challenging", "stripping", - "receptor", + "microfluidic", + "surface", + "designing", + "bbb", + "design", + "challenging", + "beta", "interacting", - "small", - "used", + "opening", + "hyperstable", + "exposed", "binders", - "avenues", - "binds", - "vitro", - "creating", - "microfluidic", "provides", + "used", + "de", + "brain", + "computationally", + "transferrin", + "avenues", + "edge", + "nm", + "targets", "polar", - "bbb", - "design", - "sheets", + "sheet", + "delivery", + "barrier", "complement", + "groups", + "strategy", "model", - "away", + "matched", "interactions", - "bind", - "brain", "protein", - "targets", - "backbone", - "designing", + "crosses", + "bind", + "20", + "approach", + "drug", + "proteins", + "vitro", "across", - "describe", - "water", - "surface", - "hyperstable", - "computationally", - "beta", + "sheets", + "strands", + "thermodynamic", "cost", - "20", - "exposed" + "backbone", + "general", + "novo", + "shuttles", + "small", + "geometrically", + "k", + "describe", + "binds", + "human", + "away", + "receptor", + "creating", + "water" ], "release_date":"2021-04-28", "publication":"\"Transferrin receptor targeting by de novo sheet extension\", Proc.Natl.Acad.Sci.USA, 118", @@ -361638,75 +362880,75 @@ ], "subtitle":"Crystal structure of computationally designed protein 2ds25.1 in complex with the human transferrin receptor ectodomain", "tags":[ - "de novo protein-metal transport complex", + "complex", "beta sheet", - "receptor", "de novo protein", "de novo protein\/metal transport", - "complex" + "de novo protein-metal transport complex", + "receptor" ], "keywords":[ "htfr", - "general", - "geometrically", - "k", - "delivery", - "strands", - "nm", - "groups", - "proteins", - "shuttles", - "approach", - "de", - "novo", - "edge", - "opening", - "transferrin", - "strategy", - "sheet", - "matched", - "thermodynamic", - "human", - "drug", - "barrier", - "crosses", - "challenging", "stripping", - "receptor", + "microfluidic", + "surface", + "designing", + "bbb", + "design", + "challenging", + "beta", "interacting", - "small", - "used", + "opening", + "hyperstable", + "exposed", "binders", - "avenues", - "binds", - "vitro", - "creating", - "microfluidic", "provides", + "used", + "de", + "brain", + "computationally", + "transferrin", + "avenues", + "edge", + "nm", + "targets", "polar", - "bbb", - "design", - "sheets", + "sheet", + "delivery", + "barrier", "complement", + "groups", + "strategy", "model", - "away", + "matched", "interactions", - "bind", - "brain", "protein", - "targets", - "backbone", - "designing", + "crosses", + "bind", + "20", + "approach", + "drug", + "proteins", + "vitro", "across", - "describe", - "water", - "surface", - "hyperstable", - "computationally", - "beta", + "sheets", + "strands", + "thermodynamic", "cost", - "20", - "exposed" + "backbone", + "general", + "novo", + "shuttles", + "small", + "geometrically", + "k", + "describe", + "binds", + "human", + "away", + "receptor", + "creating", + "water" ], "release_date":"2021-04-28", "publication":"\"Transferrin receptor targeting by de novo sheet extension\", Proc.Natl.Acad.Sci.USA, 118", @@ -361834,110 +363076,110 @@ ], "subtitle":"Hyperstable de novo tim barrel variant denovotim15", "tags":[ + "de novo", + "tim barrel", + "de novo protein", "symmetric", "hyperstable", - "de novo protein", - "de novo", - "repeat protein", - "tim barrel" + "repeat protein" ], "keywords":[ - "axes", - "confirm", - "many", - "long", - "thus", - "close", - "ions", - "signaling", - "challenge", - "scaffolds", - "designed", - "installing", - "functionalized", - "cofactors", - "dimeric", - "crystal", - "lanthanide", - "axis", "affinity", - "alternative", - "chambers", - "generating", - "420", - "proteins", - "program", - "de", - "outstanding", + "substrates", + "defined", "luminescence", + "cavities", + "outstanding", "presence", - "top", - "remains", - "serve", - "difficult", - "binds", - "often", - "structures", - "natural", - "ferredoxin", - "pockets", - "cubic", - "form", - "molecules", - "platform", "bottom", - "substrates", - "demonstrated", - "loops", - "making", - "terbium", - "large", - "defined", "extended", + "aligned", + "cofactors", + "lanthanide", + "protein", "globular", - "four", + "pockets", + "binding", + "terbium", + "close", + "site", + "novo", + "two", + "confirm", + "variety", + "succeeded", + "crystal", + "stable", + "binds", "biocatalysts", - "fused", - "challenging", - "aligned", + "construction", + "reaction", + "alternative", + "program", + "420", + "top", "dimer", - "design", "metals", - "\u00e5ngstr\u00f6m", - "symmetry", - "describe", - "high", - "cavities", - "could", - "c2", - "tim", - "consisting", - "designs", - "construction", + "thus", + "residues", + "fused", + "axis", "approach", - "novo", - "stable", - "flexible", - "barrel", - "succeeded", - "fold", - "enzymatic", + "large", + "proteins", + "ions", + "chambers", "modular", - "residues", - "reaction", - "two", - "precisely", - "problem", - "glutamate", "scaffold", - "binding", - "protein", - "variety", + "axes", + "ferredoxin", + "four", + "barrel", + "long", + "c2", "computational", - "chamber", + "symmetry", + "design", + "challenging", + "signaling", "accommodate", - "site", - "create" + "loops", + "natural", + "consisting", + "platform", + "fold", + "\u00e5ngstr\u00f6m", + "precisely", + "chamber", + "demonstrated", + "generating", + "describe", + "could", + "designed", + "form", + "often", + "many", + "structures", + "de", + "remains", + "enzymatic", + "scaffolds", + "flexible", + "serve", + "installing", + "making", + "molecules", + "high", + "difficult", + "tim", + "glutamate", + "cubic", + "problem", + "challenge", + "create", + "designs", + "functionalized", + "dimeric" ], "release_date":"2020-11-25", "publication":"\"Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion\", Proc.Natl.Acad.Sci.USA, 117, 30362-30369", @@ -361998,11 +363240,11 @@ }, { "sim":224.0, - "partner":"7ot7" + "partner":"7osu" }, { "sim":224.0, - "partner":"7osu" + "partner":"7ot7" }, { "sim":216.0, @@ -362118,113 +363360,113 @@ ], "subtitle":"De novo tim barrel-ferredoxin fold fusion homodimer with 2-histidine 2-glutamate centre tfd-he", "tags":[ - "symmetric", "homodimer", - "ferredoxin fold", - "hyperstable", - "de novo protein", "de novo", - "repeat protein", + "tim barrel", + "de novo protein", + "symmetric", + "hyperstable", + "ferredoxin fold", "symmetric fusion", - "tim barrel" + "repeat protein" ], "keywords":[ - "axes", - "confirm", - "many", - "long", - "thus", - "close", - "ions", - "signaling", - "challenge", - "scaffolds", - "designed", - "installing", - "functionalized", - "cofactors", - "dimeric", - "crystal", - "lanthanide", - "axis", "affinity", - "alternative", - "chambers", - "generating", - "420", - "proteins", - "program", - "de", - "outstanding", + "substrates", + "defined", "luminescence", + "cavities", + "outstanding", "presence", - "top", - "remains", - "serve", - "difficult", - "binds", - "often", - "structures", - "natural", - "ferredoxin", - "pockets", - "cubic", - "form", - "molecules", - "platform", "bottom", - "substrates", - "demonstrated", - "loops", - "making", - "terbium", - "large", - "defined", "extended", + "aligned", + "cofactors", + "lanthanide", + "protein", "globular", - "four", + "pockets", + "binding", + "terbium", + "close", + "site", + "novo", + "two", + "confirm", + "variety", + "succeeded", + "crystal", + "stable", + "binds", "biocatalysts", - "fused", - "challenging", - "aligned", + "construction", + "reaction", + "alternative", + "program", + "420", + "top", "dimer", - "design", "metals", - "\u00e5ngstr\u00f6m", - "symmetry", - "describe", - "high", - "cavities", - "could", - "c2", - "tim", - "consisting", - "designs", - "construction", + "thus", + "residues", + "fused", + "axis", "approach", - "novo", - "stable", - "flexible", - "barrel", - "succeeded", - "fold", - "enzymatic", + "large", + "proteins", + "ions", + "chambers", "modular", - "residues", - "reaction", - "two", - "precisely", - "problem", - "glutamate", "scaffold", - "binding", - "protein", - "variety", + "axes", + "ferredoxin", + "four", + "barrel", + "long", + "c2", "computational", - "chamber", + "symmetry", + "design", + "challenging", + "signaling", "accommodate", - "site", - "create" + "loops", + "natural", + "consisting", + "platform", + "fold", + "\u00e5ngstr\u00f6m", + "precisely", + "chamber", + "demonstrated", + "generating", + "describe", + "could", + "designed", + "form", + "often", + "many", + "structures", + "de", + "remains", + "enzymatic", + "scaffolds", + "flexible", + "serve", + "installing", + "making", + "molecules", + "high", + "difficult", + "tim", + "glutamate", + "cubic", + "problem", + "challenge", + "create", + "designs", + "functionalized", + "dimeric" ], "release_date":"2020-11-25", "publication":"\"Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion\", Proc.Natl.Acad.Sci.USA, 117, 30362-30369", @@ -362325,11 +363567,11 @@ }, { "sim":94.0, - "partner":"7ot7" + "partner":"7osu" }, { "sim":94.0, - "partner":"7osu" + "partner":"7ot7" }, { "sim":94.0, @@ -362453,110 +363695,110 @@ ], "subtitle":"De novo tim barrel-ferredoxin fold fusion homodimer with 4-glutamate centre tfd-ee", "tags":[ - "ferredoxin fold", - "homodimeric fusion", + "tim barrel", "de novo protein", - "symmetric fusion protein", "metal binding", - "tim barrel" + "ferredoxin fold", + "symmetric fusion protein", + "homodimeric fusion" ], "keywords":[ - "axes", - "confirm", - "many", - "long", - "thus", - "close", - "ions", - "signaling", - "challenge", - "scaffolds", - "designed", - "installing", - "functionalized", - "cofactors", - "dimeric", - "crystal", - "lanthanide", - "axis", "affinity", - "alternative", - "chambers", - "generating", - "420", - "proteins", - "program", - "de", - "outstanding", + "substrates", + "defined", "luminescence", + "cavities", + "outstanding", "presence", - "top", - "remains", - "serve", - "difficult", - "binds", - "often", - "structures", - "natural", - "ferredoxin", - "pockets", - "cubic", - "form", - "molecules", - "platform", "bottom", - "substrates", - "demonstrated", - "loops", - "making", - "terbium", - "large", - "defined", "extended", + "aligned", + "cofactors", + "lanthanide", + "protein", "globular", - "four", + "pockets", + "binding", + "terbium", + "close", + "site", + "novo", + "two", + "confirm", + "variety", + "succeeded", + "crystal", + "stable", + "binds", "biocatalysts", - "fused", - "challenging", - "aligned", + "construction", + "reaction", + "alternative", + "program", + "420", + "top", "dimer", - "design", "metals", - "\u00e5ngstr\u00f6m", - "symmetry", - "describe", - "high", - "cavities", - "could", - "c2", - "tim", - "consisting", - "designs", - "construction", + "thus", + "residues", + "fused", + "axis", "approach", - "novo", - "stable", - "flexible", - "barrel", - "succeeded", - "fold", - "enzymatic", + "large", + "proteins", + "ions", + "chambers", "modular", - "residues", - "reaction", - "two", - "precisely", - "problem", - "glutamate", "scaffold", - "binding", - "protein", - "variety", + "axes", + "ferredoxin", + "four", + "barrel", + "long", + "c2", "computational", - "chamber", + "symmetry", + "design", + "challenging", + "signaling", "accommodate", - "site", - "create" + "loops", + "natural", + "consisting", + "platform", + "fold", + "\u00e5ngstr\u00f6m", + "precisely", + "chamber", + "demonstrated", + "generating", + "describe", + "could", + "designed", + "form", + "often", + "many", + "structures", + "de", + "remains", + "enzymatic", + "scaffolds", + "flexible", + "serve", + "installing", + "making", + "molecules", + "high", + "difficult", + "tim", + "glutamate", + "cubic", + "problem", + "challenge", + "create", + "designs", + "functionalized", + "dimeric" ], "release_date":"2020-11-25", "publication":"\"Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion\", Proc.Natl.Acad.Sci.USA, 117, 30362-30369", @@ -362657,11 +363899,11 @@ }, { "sim":94.0, - "partner":"7ot7" + "partner":"7osu" }, { "sim":94.0, - "partner":"7osu" + "partner":"7ot7" }, { "sim":94.0, @@ -362821,68 +364063,68 @@ ], "subtitle":"Solution nmr structure of de novo designed tmb2.3", "tags":[ - "beta-barrel", "membrane protein", + "beta-barrel", "de novo design" ], "keywords":[ - "analytical", - "great", - "power", - "homology", - "importance", - "reversibly", - "magnetic", "membranes", - "proteins", - "models", - "repurposing", - "similar", - "leverage", + "form", + "slow", "technologies", - "approach", - "de", - "stable", - "novo", - "wide", - "hypothesis", - "fold", - "test", - "pore", - "enable", - "interest", - "determine", - "custom", - "nuclear", "advances", - "crystal", - "new", + "models", "limited", + "leverage", "design", - "spontaneously", - "lipid", - "synthetic", - "pores", - "structures", + "coupled", + "tmb", + "custom", + "transmembrane", + "principles", "insert", - "tmbs", - "applications", - "negative", + "interest", + "structures", + "de", "natural", + "pore", + "tmbs", "assembly", - "tmb", + "properties", + "synthetic", + "great", + "fold", + "importance", + "new", + "magnetic", + "wide", + "approach", + "known", + "proteins", + "lipid", + "achieved", + "spontaneously", + "enable", + "analytical", + "novo", + "reversibly", + "test", + "notably", + "negative", "resonance", + "power", + "nuclear", + "applications", + "crystal", + "stable", + "range", + "determine", + "hypothesis", + "repurposing", "computational", - "transmembrane", - "form", - "notably", - "principles", - "achieved", - "known", - "coupled", - "slow", - "properties", - "range" + "similar", + "pores", + "homology" ], "release_date":"2021-02-17", "publication":"\"De novo design of transmembrane beta barrels\", Science, 371", @@ -362984,71 +364226,71 @@ ], "subtitle":"Crystal structure of h49a able mutant", "tags":[ - "4-helix bundle", "de novo protein", + "ligand-binding", "de novo", - "ligand-binding" + "4-helix bundle" ], "keywords":[ - "great", - "functional", - "amino", - "proteins", - "represents", - "groups", - "chemical", - "der", - "low", - "de", - "novo", - "challenge", - "acid", - "drug", - "crystallography", - "medicine", - "preferred", + "affinity", "designed", - "enable", - "may", - "statistically", + "complex", + "mutagenesis", + "design", "interacting", - "functionalized", - "small", - "highly", - "confirmed", - "vdms", "binders", - "mer", - "two", + "preferred", + "statistically", + "cavity", + "de", + "functional", + "represents", + "medicine", + "vdm", + "structure", + "great", + "acid", + "groups", "precisely", + "crystallography", + "interactions", + "protein", + "maps", "six", - "unit", - "apixaban", - "cavity", - "design", - "sensing", "bind", - "protein", + "amino", "positions", - "using", + "drug", + "unit", + "proteins", "bound", - "submicromolar", + "low", + "molecules", + "enable", + "mer", "backbone", - "interactions", - "complex", + "vdms", + "confirmed", "van", + "novo", + "may", + "sensing", + "highly", + "small", + "forms", + "der", + "favorable", + "two", + "developed", "applications", - "vdm", - "maps", - "structure", + "chemical", + "challenge", "computational", - "favorable", - "affinity", - "molecules", + "using", "catalysis", - "developed", - "forms", - "mutagenesis" + "functionalized", + "apixaban", + "submicromolar" ], "release_date":"2020-08-26", "publication":"\"A defined structural unit enables de novo design of small-molecule-binding proteins\", Science, 369, 1227-1233", @@ -363081,11 +364323,11 @@ "seq_thr_sim_designed":[ { "sim":235.0, - "partner":"6w70" + "partner":"6w6x" }, { "sim":235.0, - "partner":"6w6x" + "partner":"6w70" } ], "seq_thr_sim_natural":[ @@ -363099,7 +364341,7 @@ ], "seq_max_sim_designed":{ "sim":235.0, - "partner":"6w70" + "partner":"6w6x" }, "seq_max_sim_natural":[ @@ -363222,63 +364464,63 @@ "transmembrane beta-barrels" ], "keywords":[ - "analytical", - "great", - "power", - "homology", - "importance", - "reversibly", - "magnetic", "membranes", - "proteins", - "models", - "repurposing", - "similar", - "leverage", + "form", + "slow", "technologies", - "approach", - "de", - "stable", - "novo", - "wide", - "hypothesis", - "fold", - "test", - "pore", - "enable", - "interest", - "determine", - "custom", - "nuclear", "advances", - "crystal", - "new", + "models", "limited", + "leverage", "design", - "spontaneously", - "lipid", - "synthetic", - "pores", - "structures", + "coupled", + "tmb", + "custom", + "transmembrane", + "principles", "insert", - "tmbs", - "applications", - "negative", + "interest", + "structures", + "de", "natural", + "pore", + "tmbs", "assembly", - "tmb", + "properties", + "synthetic", + "great", + "fold", + "importance", + "new", + "magnetic", + "wide", + "approach", + "known", + "proteins", + "lipid", + "achieved", + "spontaneously", + "enable", + "analytical", + "novo", + "reversibly", + "test", + "notably", + "negative", "resonance", + "power", + "nuclear", + "applications", + "crystal", + "stable", + "range", + "determine", + "hypothesis", + "repurposing", "computational", - "transmembrane", - "form", - "notably", - "principles", - "achieved", - "known", - "coupled", - "slow", - "properties", - "range" + "similar", + "pores", + "homology" ], "release_date":"2021-02-17", "publication":"\"De novo design of transmembrane beta barrels\", Science, 371", @@ -363396,11 +364638,11 @@ ], "subtitle":"Solution nmr structure of de novo designed rossmann 2x3 fold protein r2x3_168, northeast structural genomics consortium (nesg) target or386", "tags":[ - "rosemann 2x3 fold nmr", + "nesg", + "de novo protein", "northeast structural genomics consortium", "structural genomics", - "de novo protein", - "nesg", + "rosemann 2x3 fold nmr", "psi-biology" ], "keywords":[ @@ -363442,11 +364684,11 @@ }, { "sim":56.0, - "partner":"2kpo" + "partner":"2lv8" }, { "sim":56.0, - "partner":"2lv8" + "partner":"2kpo" }, { "sim":54.0, @@ -363590,83 +364832,83 @@ ], "subtitle":"Hierarchical design of multi-scale protein complexes by combinatorial assembly of oligomeric helical bundle and repeat protein building blocks", "tags":[ - "de novo design", "de novo protein", - "helical fusion" + "helical fusion", + "de novo design" ], "keywords":[ - "library", - "guided", + "designed", + "complex", + "fuse", + "designing", + "rigidly", + "design", + "repeat", + "show", + "classes", + "fusion", + "methods", + "de", + "named", + "first", + "oligomers", + "group", "symmetries", - "general", - "generating", + "oligomeric", "hierarchical", - "oligomers", - "rigidly", "nm", - "proteins", - "large", - "architecture", - "dhrs", - "group", - "assemblies", - "approach", - "generate", - "accurately", - "described", - "wide", - "sets", "route", - "de", - "novo", - "named", - "crystallography", - "point", - "including", - "designed", - "modular", - "diameter", - "would", - "worms", - "range", - "broad", - "robust", "rigid", - "icosahedral", - "two", "provide", - "classes", - "methods", - "systematic", + "dihedral", + "new", + "block", + "point", + "library", + "cyclic", + "43", + "crystallography", + "protein", + "wide", + "approach", "blocks", - "bundle", - "show", - "design", + "helical", + "would", + "develop", + "proteins", + "large", + "utility", "software", "characterization", - "helical", - "protein", - "microscopy", - "using", - "complex", - "designing", - "dihedral", + "systematic", "nanomaterials", - "block", - "repeat", - "fuse", - "43", - "fusion", - "computational", - "oligomeric", + "broad", + "guided", + "modular", + "architecture", + "microscopy", + "diameter", + "described", + "including", + "general", + "novo", "building", + "accurately", + "two", + "generating", + "worms", "hbs", - "first", + "dhrs", + "range", + "assemblies", + "icosahedral", "nanocage", - "cyclic", - "utility", - "new", - "develop" + "computational", + "bundle", + "using", + "generate", + "robust", + "sets" ], "release_date":"2021-06-02", "publication":"\"Design of multi-scale protein complexes by hierarchical building block fusion\", Nat Commun, 12, 2294-2294", @@ -363699,11 +364941,11 @@ "seq_thr_sim_designed":[ { "sim":328.0, - "partner":"9dnd" + "partner":"9dne" }, { "sim":328.0, - "partner":"9dne" + "partner":"9dnd" }, { "sim":315.0, @@ -363711,11 +364953,11 @@ }, { "sim":314.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":314.0, - "partner":"8cus" + "partner":"8cut" }, { "sim":310.0, @@ -363844,7 +365086,7 @@ ], "seq_max_sim_designed":{ "sim":328.0, - "partner":"9dnd" + "partner":"9dne" }, "seq_max_sim_natural":{ "sim":353.0, @@ -363967,83 +365209,83 @@ ], "subtitle":"Hierarchical design of multi-scale protein complexes by combinatorial assembly of oligomeric helical bundle and repeat protein building blocks", "tags":[ - "de novo design", "de novo protein", - "helical fusion" + "helical fusion", + "de novo design" ], "keywords":[ - "library", - "guided", + "designed", + "complex", + "fuse", + "designing", + "rigidly", + "design", + "repeat", + "show", + "classes", + "fusion", + "methods", + "de", + "named", + "first", + "oligomers", + "group", "symmetries", - "general", - "generating", + "oligomeric", "hierarchical", - "oligomers", - "rigidly", "nm", - "proteins", - "large", - "architecture", - "dhrs", - "group", - "assemblies", - "approach", - "generate", - "accurately", - "described", - "wide", - "sets", "route", - "de", - "novo", - "named", - "crystallography", - "point", - "including", - "designed", - "modular", - "diameter", - "would", - "worms", - "range", - "broad", - "robust", "rigid", - "icosahedral", - "two", "provide", - "classes", - "methods", - "systematic", + "dihedral", + "new", + "block", + "point", + "library", + "cyclic", + "43", + "crystallography", + "protein", + "wide", + "approach", "blocks", - "bundle", - "show", - "design", + "helical", + "would", + "develop", + "proteins", + "large", + "utility", "software", "characterization", - "helical", - "protein", - "microscopy", - "using", - "complex", - "designing", - "dihedral", + "systematic", "nanomaterials", - "block", - "repeat", - "fuse", - "43", - "fusion", - "computational", - "oligomeric", + "broad", + "guided", + "modular", + "architecture", + "microscopy", + "diameter", + "described", + "including", + "general", + "novo", "building", + "accurately", + "two", + "generating", + "worms", "hbs", - "first", + "dhrs", + "range", + "assemblies", + "icosahedral", "nanocage", - "cyclic", - "utility", - "new", - "develop" + "computational", + "bundle", + "using", + "generate", + "robust", + "sets" ], "release_date":"2021-06-02", "publication":"\"Design of multi-scale protein complexes by hierarchical building block fusion\", Nat Commun, 12, 2294-2294", @@ -364260,82 +365502,82 @@ ], "subtitle":"C3_crown-05", "tags":[ - "helical bundle repeat protein", - "de novo protein" + "de novo protein", + "helical bundle repeat protein" ], "keywords":[ - "library", - "guided", + "designed", + "complex", + "fuse", + "designing", + "rigidly", + "design", + "repeat", + "show", + "classes", + "fusion", + "methods", + "de", + "named", + "first", + "oligomers", + "group", "symmetries", - "general", - "generating", + "oligomeric", "hierarchical", - "oligomers", - "rigidly", "nm", - "proteins", - "large", - "architecture", - "dhrs", - "group", - "assemblies", - "approach", - "generate", - "accurately", - "described", - "wide", - "sets", "route", - "de", - "novo", - "named", - "crystallography", - "point", - "including", - "designed", - "modular", - "diameter", - "would", - "worms", - "range", - "broad", - "robust", "rigid", - "icosahedral", - "two", "provide", - "classes", - "methods", - "systematic", + "dihedral", + "new", + "block", + "point", + "library", + "cyclic", + "43", + "crystallography", + "protein", + "wide", + "approach", "blocks", - "bundle", - "show", - "design", + "helical", + "would", + "develop", + "proteins", + "large", + "utility", "software", "characterization", - "helical", - "protein", - "microscopy", - "using", - "complex", - "designing", - "dihedral", + "systematic", "nanomaterials", - "block", - "repeat", - "fuse", - "43", - "fusion", - "computational", - "oligomeric", + "broad", + "guided", + "modular", + "architecture", + "microscopy", + "diameter", + "described", + "including", + "general", + "novo", "building", + "accurately", + "two", + "generating", + "worms", "hbs", - "first", + "dhrs", + "range", + "assemblies", + "icosahedral", "nanocage", - "cyclic", - "utility", - "new", - "develop" + "computational", + "bundle", + "using", + "generate", + "robust", + "sets" ], "release_date":"2020-12-23", "publication":"\"Design of multi-scale protein complexes by hierarchical building block fusion\", Nat Commun, 12, 2294-2294", @@ -364551,91 +365793,91 @@ ], "subtitle":"Computationally designed right-handed alpha\/alpha single-chain toroid with 9 repeats", "tags":[ - "computationally designed", "toroid", - "helix-turn-helix", + "de novo", "de novo protein", - "de novo" + "helix-turn-helix", + "computationally designed" ], "keywords":[ - "domain", - "constructs", - "studies", - "sh2", - "potent", - "scaffolds", - "designed", - "receptor", - "towards", - "smaller", - "particles", - "hexameric", - "based", - "sequences", - "enhanced", - "vhh", - "display", - "repeat", - "however", - "latter", - "biotechnology", - "interaction", - "array", - "longer", - "proteins", - "viral", - "de", - "inefficient", + "repeats", "finally", - "ctrps", - "trimeric", - "structures", "proved", - "function", + "structural", + "repeat", + "solubility", + "new", + "particles", + "protein", + "study", + "increased", + "significantly", + "binding", + "novo", + "demonstrate", + "domains", "circular", "motifs", - "significantly", - "form", - "functionalization", - "repeated", - "stability", - "neutralization", - "generation", - "demonstrated", + "two", + "applications", + "prior", + "receptor", + "antiparallel", "bundles", - "increased", - "1", - "tandem", + "however", + "closed", + "sh2", + "functionalization", "surfaces", "useful", - "applications", - "describe", - "repeats", + "stability", + "proteins", + "capable", + "2", + "tandem", + "neutralization", + "contain", + "ctrps", "subunits", - "structural", - "range", - "solubility", - "demonstrate", - "closed", - "prior", + "longer", + "1", + "hexameric", + "enhanced", + "display", + "different", + "domain", + "sizes", "also", - "study", - "novo", "wide", - "sizes", - "different", - "capable", - "affinities", - "two", - "antiparallel", + "interaction", + "viral", + "demonstrated", + "repeated", + "range", + "describe", + "designed", + "form", + "trimeric", + "generation", + "sequences", + "array", + "latter", + "structures", + "de", + "constructs", + "based", + "vhh", + "scaffolds", "homotrimeric", - "domains", - "significant", - "protein", - "2", - "binding", - "contain", - "new" + "function", + "inefficient", + "towards", + "smaller", + "studies", + "potent", + "affinities", + "biotechnology", + "significant" ], "release_date":"2021-07-14", "publication":"\"Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces\", Commun Biol, 4, 1240-1240", @@ -364835,91 +366077,91 @@ ], "subtitle":"Computationally designed right-handed alpha\/alpha homotrimeric toroid with 3 repeats per subunit", "tags":[ - "computationally designed", "toroid", - "helix-turn-helix", + "de novo", "de novo protein", - "de novo" + "helix-turn-helix", + "computationally designed" ], "keywords":[ - "domain", - "constructs", - "studies", - "sh2", - "potent", - "scaffolds", - "designed", - "receptor", - "towards", - "smaller", - "particles", - "hexameric", - "based", - "sequences", - "enhanced", - "vhh", - "display", - "repeat", - "however", - "latter", - "biotechnology", - "interaction", - "array", - "longer", - "proteins", - "viral", - "de", - "inefficient", + "repeats", "finally", - "ctrps", - "trimeric", - "structures", "proved", - "function", + "structural", + "repeat", + "solubility", + "new", + "particles", + "protein", + "study", + "increased", + "significantly", + "binding", + "novo", + "demonstrate", + "domains", "circular", "motifs", - "significantly", - "form", - "functionalization", - "repeated", - "stability", - "neutralization", - "generation", - "demonstrated", + "two", + "applications", + "prior", + "receptor", + "antiparallel", "bundles", - "increased", - "1", - "tandem", + "however", + "closed", + "sh2", + "functionalization", "surfaces", "useful", - "applications", - "describe", - "repeats", + "stability", + "proteins", + "capable", + "2", + "tandem", + "neutralization", + "contain", + "ctrps", "subunits", - "structural", - "range", - "solubility", - "demonstrate", - "closed", - "prior", + "longer", + "1", + "hexameric", + "enhanced", + "display", + "different", + "domain", + "sizes", "also", - "study", - "novo", "wide", - "sizes", - "different", - "capable", - "affinities", - "two", - "antiparallel", + "interaction", + "viral", + "demonstrated", + "repeated", + "range", + "describe", + "designed", + "form", + "trimeric", + "generation", + "sequences", + "array", + "latter", + "structures", + "de", + "constructs", + "based", + "vhh", + "scaffolds", "homotrimeric", - "domains", - "significant", - "protein", - "2", - "binding", - "contain", - "new" + "function", + "inefficient", + "towards", + "smaller", + "studies", + "potent", + "affinities", + "biotechnology", + "significant" ], "release_date":"2021-07-14", "publication":"\"Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces\", Commun Biol, 4, 1240-1240", @@ -365152,83 +366394,83 @@ ], "subtitle":"Cryoem structure of designed helical fusion protein c4_nat_hfuse-7900", "tags":[ - "helical repeat", + "helical bundle", "de novo protein", - "helical bundle" + "helical repeat" ], "keywords":[ - "library", - "guided", + "designed", + "complex", + "fuse", + "designing", + "rigidly", + "design", + "repeat", + "show", + "classes", + "fusion", + "methods", + "de", + "named", + "first", + "oligomers", + "group", "symmetries", - "general", - "generating", + "oligomeric", "hierarchical", - "oligomers", - "rigidly", "nm", - "proteins", - "large", - "architecture", - "dhrs", - "group", - "assemblies", - "approach", - "generate", - "accurately", - "described", - "wide", - "sets", "route", - "de", - "novo", - "named", - "crystallography", - "point", - "including", - "designed", - "modular", - "diameter", - "would", - "worms", - "range", - "broad", - "robust", "rigid", - "icosahedral", - "two", "provide", - "classes", - "methods", - "systematic", + "dihedral", + "new", + "block", + "point", + "library", + "cyclic", + "43", + "crystallography", + "protein", + "wide", + "approach", "blocks", - "bundle", - "show", - "design", + "helical", + "would", + "develop", + "proteins", + "large", + "utility", "software", "characterization", - "helical", - "protein", - "microscopy", - "using", - "complex", - "designing", - "dihedral", + "systematic", "nanomaterials", - "block", - "repeat", - "fuse", - "43", - "fusion", - "computational", - "oligomeric", + "broad", + "guided", + "modular", + "architecture", + "microscopy", + "diameter", + "described", + "including", + "general", + "novo", "building", + "accurately", + "two", + "generating", + "worms", "hbs", - "first", + "dhrs", + "range", + "assemblies", + "icosahedral", "nanocage", - "cyclic", - "utility", - "new", - "develop" + "computational", + "bundle", + "using", + "generate", + "robust", + "sets" ], "release_date":"2020-12-23", "publication":"\"Design of multi-scale protein complexes by hierarchical building block fusion\", Nat Commun, 12, 2294-2294", @@ -365281,15 +366523,15 @@ }, { "sim":110.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":110.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":110.0, - "partner":"8cus" + "partner":"8cwz" }, { "sim":109.0, @@ -365305,11 +366547,11 @@ }, { "sim":60.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":60.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":57.0, @@ -365481,82 +366723,82 @@ ], "subtitle":"C3_hd-1069 (1bh-69) - fusion protein of helical bundle and repeat protein", "tags":[ - "helical bundle repeat protein", - "de novo protein" + "de novo protein", + "helical bundle repeat protein" ], "keywords":[ - "library", - "guided", + "designed", + "complex", + "fuse", + "designing", + "rigidly", + "design", + "repeat", + "show", + "classes", + "fusion", + "methods", + "de", + "named", + "first", + "oligomers", + "group", "symmetries", - "general", - "generating", + "oligomeric", "hierarchical", - "oligomers", - "rigidly", "nm", - "proteins", - "large", - "architecture", - "dhrs", - "group", - "assemblies", - "approach", - "generate", - "accurately", - "described", - "wide", - "sets", "route", - "de", - "novo", - "named", - "crystallography", - "point", - "including", - "designed", - "modular", - "diameter", - "would", - "worms", - "range", - "broad", - "robust", "rigid", - "icosahedral", - "two", "provide", - "classes", - "methods", - "systematic", + "dihedral", + "new", + "block", + "point", + "library", + "cyclic", + "43", + "crystallography", + "protein", + "wide", + "approach", "blocks", - "bundle", - "show", - "design", + "helical", + "would", + "develop", + "proteins", + "large", + "utility", "software", "characterization", - "helical", - "protein", - "microscopy", - "using", - "complex", - "designing", - "dihedral", + "systematic", "nanomaterials", - "block", - "repeat", - "fuse", - "43", - "fusion", - "computational", - "oligomeric", + "broad", + "guided", + "modular", + "architecture", + "microscopy", + "diameter", + "described", + "including", + "general", + "novo", "building", + "accurately", + "two", + "generating", + "worms", "hbs", - "first", + "dhrs", + "range", + "assemblies", + "icosahedral", "nanocage", - "cyclic", - "utility", - "new", - "develop" + "computational", + "bundle", + "using", + "generate", + "robust", + "sets" ], "release_date":"2020-12-23", "publication":"\"Design of multi-scale protein complexes by hierarchical building block fusion\", Nat Commun, 12, 2294-2294", @@ -365816,75 +367058,75 @@ ], "subtitle":"Solution nmr structure of the s0_2.126 designed protein", "tags":[ - "de novo protein", - "designed protein" + "designed protein", + "de novo protein" ], "keywords":[ - "responses", - "cornerstone", - "neutralization", - "structural", - "toward", - "opens", - "cocktails", - "called", - "overall", "vaccinology", - "functional", - "proteins", - "syncytial", - "virus", - "immunogens", - "lack", - "neutralizing", - "respiratory", + "complex", "defined", - "approach", - "de", - "novo", - "applicable", - "presenting", - "challenge", - "antibody", - "possibility", - "induction", - "preexisting", + "responses", "engineered", - "remains", - "mice", - "successful", "displaying", - "nonhuman", - "methodological", - "topobuilder", - "primates", - "induced", - "repertoire", - "robust", - "specific", - "furthermore", - "generally", "design", - "protein", - "precise", - "present", - "complex", - "natural", + "methodological", + "however", + "immunogens", + "structural", "development", - "function", - "three", + "opens", + "de", + "natural", + "functional", + "vaccines", + "furthermore", + "overall", "biological", - "motifs", + "remains", + "three", + "respiratory", "epitopes", - "vaccines", - "however", - "major", + "targeting", + "called", + "specific", + "virus", + "successful", + "therapeutic", + "presenting", + "protein", "antibodies", + "function", + "applicable", + "approach", + "syncytial", + "proteins", + "generally", + "algorithm", + "novo", "refocused", - "therapeutic", + "neutralization", + "repertoire", + "neutralizing", + "mice", + "preexisting", + "motifs", + "major", + "induction", "expanding", - "algorithm", - "targeting" + "present", + "precise", + "cornerstone", + "induced", + "toward", + "nonhuman", + "cocktails", + "primates", + "challenge", + "possibility", + "topobuilder", + "robust", + "lack", + "antibody" ], "release_date":"2020-04-15", "publication":"\"De novo protein design enables the precise induction of RSV-neutralizing antibodies\", Science, 368", @@ -366116,77 +367358,77 @@ ], "subtitle":"Crystal structure of a computationally designed immunogen s2_1.2 in complex with its elicited antibody c57", "tags":[ - "immune system", - "immunogen", "epitope scaffold", + "immunogen", + "immune system", "de novo designed protein" ], "keywords":[ - "responses", - "cornerstone", - "neutralization", - "structural", - "toward", - "opens", - "cocktails", - "called", - "overall", "vaccinology", - "functional", - "proteins", - "syncytial", - "virus", - "immunogens", - "lack", - "neutralizing", - "respiratory", + "complex", "defined", - "approach", - "de", - "novo", - "applicable", - "presenting", - "challenge", - "antibody", - "possibility", - "induction", - "preexisting", + "responses", "engineered", - "remains", - "mice", - "successful", "displaying", - "nonhuman", - "methodological", - "topobuilder", - "primates", - "induced", - "repertoire", - "robust", - "specific", - "furthermore", - "generally", "design", - "protein", - "precise", - "present", - "complex", - "natural", + "methodological", + "however", + "immunogens", + "structural", "development", - "function", - "three", + "opens", + "de", + "natural", + "functional", + "vaccines", + "furthermore", + "overall", "biological", - "motifs", + "remains", + "three", + "respiratory", "epitopes", - "vaccines", - "however", - "major", + "targeting", + "called", + "specific", + "virus", + "successful", + "therapeutic", + "presenting", + "protein", "antibodies", + "function", + "applicable", + "approach", + "syncytial", + "proteins", + "generally", + "algorithm", + "novo", "refocused", - "therapeutic", + "neutralization", + "repertoire", + "neutralizing", + "mice", + "preexisting", + "motifs", + "major", + "induction", "expanding", - "algorithm", - "targeting" + "present", + "precise", + "cornerstone", + "induced", + "toward", + "nonhuman", + "cocktails", + "primates", + "challenge", + "possibility", + "topobuilder", + "robust", + "lack", + "antibody" ], "release_date":"2020-04-22", "publication":"\"De novo protein design enables the precise induction of RSV-neutralizing antibodies\", Science, 368", @@ -366280,130 +367522,130 @@ ], "subtitle":"Crystal structure of a de novo designed parallel four-helix coiled coil, 2-ek-4", "tags":[ - "parallel", "de novo protein", "coiled coil", + "parallel", "tetramer" ], "keywords":[ - "tetramer", - "unfolding", - "improve", - "studied", - "herein", - "use", - "metal", "trimer", - "scaffolds", + "structural", + "additional", + "tuned", + "therefore", + "well", + "widespread", "acid", - "crystallography", + "solubility", + "truncation", + "protein", + "homotetramers", + "tetramerization", + "binding", + "changes", + "focus", + "unfolding", + "produced", + "investigations", + "novo", + "general", + "domains", + "systems", + "anticipate", + "applications", "temperatures", - "designed", - "switch", - "affecting", - "requires", - "40", + "cause", "robust", - "provide", - "parallel", + "tertiary", + "introduction", + "improve", + "superficial", + "initial", + "characterized", + "metal", + "predictable", + "starting", + "requiring", + "homotetrameric", + "macromolecular", + "electrostatics", + "studied", + "quaternary", + "behaviors", + "stability", + "proteins", + "sites", "generally", - "features", - "increasingly", - "instead", - "based", - "sequences", + "reliably", + "use", + "may", + "small", + "coils", "robustness", - "synthetic", - "interactions", - "anticipate", - "designing", - "therefore", - "structure", - "widespread", - "turn", - "applied", - "biotechnology", - "quaternary", - "starting", + "features", + "updated", "like", + "set", "direct", - "without", - "coiled", - "general", - "allows", - "proteins", - "cell", - "de", - "characterized", - "variants", - "electrostatics", - "focus", - "small", + "surface", + "designing", + "tetramer", + "design", + "active", "used", - "initial", - "requiring", - "often", - "introduction", - "cause", - "predictable", - "macromolecular", - "coils", - "natural", - "tertiary", - "function", - "behaviors", - "solution", + "instead", "biology", - "homotetrameric", - "coil", - "superficial", - "additional", - "systems", - "reliably", - "previously", + "natural", + "alterations", + "40", + "oligomeric", "properties", - "stability", - "amino", + "fold", "imperative", - "changes", - "call", - "may", - "active", - "anticipated", - "design", - "produced", - "applications", - "surface", + "gross", + "cell", + "amino", + "solution", + "understood", + "allows", + "maintain", + "applied", + "requires", + "parallel", "sequence", - "truncation", - "structural", + "achieving", "incorporate", "range", - "sites", - "solubility", - "maintain", - "alterations", + "affecting", + "reveal", + "designed", + "often", + "anticipated", + "sequences", "one", - "updated", - "novo", - "fold", + "variants", + "de", + "call", "95", - "well", - "reveal", - "understood", + "previously", + "based", + "without", + "structure", + "synthetic", + "scaffolds", + "provide", + "herein", + "crystallography", + "interactions", "state", - "tuned", - "domains", - "set", - "achieving", - "investigations", - "protein", + "function", + "coiled", "attributes", - "tetramerization", - "oligomeric", - "gross", - "homotetramers", - "binding" + "coil", + "turn", + "increasingly", + "switch", + "biotechnology" ], "release_date":"2020-03-18", "publication":"\"RobustDe Novo-Designed Homotetrameric Coiled Coils\", Biochemistry, 59, 1087-1092", @@ -366629,130 +367871,130 @@ ], "subtitle":"Crystal structure of a de novo designed parallel four-helix coiled coil, 3-ek-4", "tags":[ - "parallel", "de novo protein", "coiled coil", + "parallel", "tetramer" ], "keywords":[ - "tetramer", - "unfolding", - "improve", - "studied", - "herein", - "use", - "metal", "trimer", - "scaffolds", + "structural", + "additional", + "tuned", + "therefore", + "well", + "widespread", "acid", - "crystallography", + "solubility", + "truncation", + "protein", + "homotetramers", + "tetramerization", + "binding", + "changes", + "focus", + "unfolding", + "produced", + "investigations", + "novo", + "general", + "domains", + "systems", + "anticipate", + "applications", "temperatures", - "designed", - "switch", - "affecting", - "requires", - "40", + "cause", "robust", - "provide", - "parallel", + "tertiary", + "introduction", + "improve", + "superficial", + "initial", + "characterized", + "metal", + "predictable", + "starting", + "requiring", + "homotetrameric", + "macromolecular", + "electrostatics", + "studied", + "quaternary", + "behaviors", + "stability", + "proteins", + "sites", "generally", - "features", - "increasingly", - "instead", - "based", - "sequences", + "reliably", + "use", + "may", + "small", + "coils", "robustness", - "synthetic", - "interactions", - "anticipate", - "designing", - "therefore", - "structure", - "widespread", - "turn", - "applied", - "biotechnology", - "quaternary", - "starting", + "features", + "updated", "like", + "set", "direct", - "without", - "coiled", - "general", - "allows", - "proteins", - "cell", - "de", - "characterized", - "variants", - "electrostatics", - "focus", - "small", + "surface", + "designing", + "tetramer", + "design", + "active", "used", - "initial", - "requiring", - "often", - "introduction", - "cause", - "predictable", - "macromolecular", - "coils", - "natural", - "tertiary", - "function", - "behaviors", - "solution", + "instead", "biology", - "homotetrameric", - "coil", - "superficial", - "additional", - "systems", - "reliably", - "previously", + "natural", + "alterations", + "40", + "oligomeric", "properties", - "stability", - "amino", + "fold", "imperative", - "changes", - "call", - "may", - "active", - "anticipated", - "design", - "produced", - "applications", - "surface", + "gross", + "cell", + "amino", + "solution", + "understood", + "allows", + "maintain", + "applied", + "requires", + "parallel", "sequence", - "truncation", - "structural", + "achieving", "incorporate", "range", - "sites", - "solubility", - "maintain", - "alterations", + "affecting", + "reveal", + "designed", + "often", + "anticipated", + "sequences", "one", - "updated", - "novo", - "fold", + "variants", + "de", + "call", "95", - "well", - "reveal", - "understood", + "previously", + "based", + "without", + "structure", + "synthetic", + "scaffolds", + "provide", + "herein", + "crystallography", + "interactions", "state", - "tuned", - "domains", - "set", - "achieving", - "investigations", - "protein", + "function", + "coiled", "attributes", - "tetramerization", - "oligomeric", - "gross", - "homotetramers", - "binding" + "coil", + "turn", + "increasingly", + "switch", + "biotechnology" ], "release_date":"2020-03-18", "publication":"\"RobustDe Novo-Designed Homotetrameric Coiled Coils\", Biochemistry, 59, 1087-1092", @@ -366795,11 +368037,11 @@ }, { "sim":1.0, - "partner":"4pna" + "partner":"6xy1" }, { "sim":1.0, - "partner":"6xy1" + "partner":"4pna" }, { "sim":0.9987999797, @@ -366809,6 +368051,10 @@ "sim":1.0, "partner":"7bim" }, + { + "sim":1.0, + "partner":"7nfg" + }, { "sim":1.0, "partner":"5ez8" @@ -366819,7 +368065,7 @@ }, { "sim":1.0, - "partner":"7nfg" + "partner":"7nfi" }, { "sim":1.0, @@ -366833,10 +368079,6 @@ "sim":0.9805999994, "partner":"7nfo" }, - { - "sim":1.0, - "partner":"7nfi" - }, { "sim":1.0, "partner":"6zt1" @@ -366866,28 +368108,32 @@ "partner":"6g6g" }, { - "sim":1.0, - "partner":"7bav" + "sim":0.9986000061, + "partner":"5et3" }, { - "sim":0.980700016, - "partner":"3s0r" + "sim":1.0, + "partner":"5hkn" }, { - "sim":0.9986000061, - "partner":"5et3" + "sim":1.0, + "partner":"7bas" }, { "sim":1.0, - "partner":"5hkn" + "partner":"7bav" + }, + { + "sim":0.980700016, + "partner":"3s0r" }, { "sim":0.992200017, "partner":"5hkr" }, { - "sim":1.0, - "partner":"7bas" + "sim":0.954400003, + "partner":"9gf2" }, { "sim":0.9575999975, @@ -366905,10 +368151,6 @@ "sim":1.0, "partner":"6g6c" }, - { - "sim":0.9789999723, - "partner":"4pnd" - }, { "sim":0.9957000017, "partner":"6g6b" @@ -366917,6 +368159,10 @@ "sim":0.959100008, "partner":"8a09" }, + { + "sim":0.9789999723, + "partner":"4pnd" + }, { "sim":0.96450001, "partner":"7baw" @@ -366949,7 +368195,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"5ez8" + "partner":"6xy1" }, "struct_max_sim_natural":{ "sim":0.897300005, @@ -366995,130 +368241,130 @@ ], "subtitle":"Crystal structure of a de novo designed parallel four-helix coiled coil, 4-ke-4", "tags":[ - "parallel", "de novo protein", "coiled coil", + "parallel", "tetramer" ], "keywords":[ - "tetramer", - "unfolding", - "improve", - "studied", - "herein", - "use", - "metal", "trimer", - "scaffolds", + "structural", + "additional", + "tuned", + "therefore", + "well", + "widespread", "acid", - "crystallography", + "solubility", + "truncation", + "protein", + "homotetramers", + "tetramerization", + "binding", + "changes", + "focus", + "unfolding", + "produced", + "investigations", + "novo", + "general", + "domains", + "systems", + "anticipate", + "applications", "temperatures", - "designed", - "switch", - "affecting", - "requires", - "40", + "cause", "robust", - "provide", - "parallel", + "tertiary", + "introduction", + "improve", + "superficial", + "initial", + "characterized", + "metal", + "predictable", + "starting", + "requiring", + "homotetrameric", + "macromolecular", + "electrostatics", + "studied", + "quaternary", + "behaviors", + "stability", + "proteins", + "sites", "generally", - "features", - "increasingly", - "instead", - "based", - "sequences", + "reliably", + "use", + "may", + "small", + "coils", "robustness", - "synthetic", - "interactions", - "anticipate", - "designing", - "therefore", - "structure", - "widespread", - "turn", - "applied", - "biotechnology", - "quaternary", - "starting", + "features", + "updated", "like", + "set", "direct", - "without", - "coiled", - "general", - "allows", - "proteins", - "cell", - "de", - "characterized", - "variants", - "electrostatics", - "focus", - "small", + "surface", + "designing", + "tetramer", + "design", + "active", "used", - "initial", - "requiring", - "often", - "introduction", - "cause", - "predictable", - "macromolecular", - "coils", - "natural", - "tertiary", - "function", - "behaviors", - "solution", + "instead", "biology", - "homotetrameric", - "coil", - "superficial", - "additional", - "systems", - "reliably", - "previously", + "natural", + "alterations", + "40", + "oligomeric", "properties", - "stability", - "amino", + "fold", "imperative", - "changes", - "call", - "may", - "active", - "anticipated", - "design", - "produced", - "applications", - "surface", + "gross", + "cell", + "amino", + "solution", + "understood", + "allows", + "maintain", + "applied", + "requires", + "parallel", "sequence", - "truncation", - "structural", + "achieving", "incorporate", "range", - "sites", - "solubility", - "maintain", - "alterations", + "affecting", + "reveal", + "designed", + "often", + "anticipated", + "sequences", "one", - "updated", - "novo", - "fold", + "variants", + "de", + "call", "95", - "well", - "reveal", - "understood", + "previously", + "based", + "without", + "structure", + "synthetic", + "scaffolds", + "provide", + "herein", + "crystallography", + "interactions", "state", - "tuned", - "domains", - "set", - "achieving", - "investigations", - "protein", + "function", + "coiled", "attributes", - "tetramerization", - "oligomeric", - "gross", - "homotetramers", - "binding" + "coil", + "turn", + "increasingly", + "switch", + "biotechnology" ], "release_date":"2020-03-18", "publication":"\"RobustDe Novo-Designed Homotetrameric Coiled Coils\", Biochemistry, 59, 1087-1092", @@ -367155,13 +368401,21 @@ ], "struct_thr_sim_designed":[ + { + "sim":1.0, + "partner":"4pn9" + }, + { + "sim":1.0, + "partner":"4pna" + }, { "sim":0.9983999729, "partner":"6eiz" }, { - "sim":0.9933999777, - "partner":"7nfo" + "sim":1.0, + "partner":"7bim" }, { "sim":0.9789000154, @@ -367169,63 +368423,67 @@ }, { "sim":1.0, - "partner":"7nfj" + "partner":"5ez8" }, { "sim":1.0, - "partner":"7nfl" + "partner":"7nff" }, { "sim":1.0, - "partner":"4pn9" - }, - { - "sim":0.9973999858, - "partner":"7nfh" + "partner":"7nfg" }, { "sim":1.0, - "partner":"7bav" + "partner":"7nfi" }, { "sim":1.0, - "partner":"4pna" + "partner":"7nfj" }, { "sim":1.0, - "partner":"7bim" + "partner":"7nfl" }, { - "sim":0.9789000154, - "partner":"7nfk" + "sim":1.0, + "partner":"7nfm" }, { "sim":1.0, "partner":"8b16" }, { - "sim":1.0, - "partner":"5ez8" + "sim":0.9933999777, + "partner":"7nfo" }, { "sim":1.0, - "partner":"7bas" + "partner":"6yb2" }, { - "sim":0.9764999747, - "partner":"8b15" + "sim":0.9984999895, + "partner":"6zt1" }, { "sim":1.0, "partner":"7a1t" }, { - "sim":0.9984999895, - "partner":"6zt1" + "sim":1.0, + "partner":"7bas" + }, + { + "sim":1.0, + "partner":"7bav" }, { "sim":0.9789000154, - "partner":"6eik" + "partner":"7nfk" + }, + { + "sim":0.9764999747, + "partner":"8b15" }, { "sim":1.0, @@ -367233,7 +368491,7 @@ }, { "sim":1.0, - "partner":"7nfn" + "partner":"5eza" }, { "sim":1.0, @@ -367244,84 +368502,88 @@ "partner":"6g6g" }, { - "sim":0.9926000237, - "partner":"7bau" + "sim":1.0, + "partner":"7nfn" }, { - "sim":1.0, - "partner":"5ezc" + "sim":0.9789000154, + "partner":"6eik" }, { "sim":1.0, - "partner":"7nff" + "partner":"5ezc" }, { - "sim":1.0, - "partner":"7nfg" + "sim":0.9973999858, + "partner":"7nfh" }, { "sim":1.0, - "partner":"7nfi" + "partner":"6xxz" }, { "sim":1.0, - "partner":"7nfm" + "partner":"6xy0" }, { "sim":1.0, - "partner":"6yb2" + "partner":"7nfp" }, { - "sim":0.9912999868, - "partner":"6g6b" + "sim":1.0, + "partner":"6g6c" }, { - "sim":1.0, - "partner":"7baw" + "sim":0.9769999981, + "partner":"6yb0" }, { "sim":0.9951000214, "partner":"6g6a" }, + { + "sim":0.9912999868, + "partner":"6g6b" + }, { "sim":1.0, - "partner":"5eza" + "partner":"7baw" }, { - "sim":0.996999979, - "partner":"7bat" + "sim":0.9987000227, + "partner":"6g65" }, { "sim":1.0, - "partner":"6xxz" + "partner":"6g67" }, { - "sim":1.0, - "partner":"6xy0" + "sim":0.9966999888, + "partner":"6g6d" }, { - "sim":1.0, - "partner":"7nfp" + "sim":0.996999979, + "partner":"7bat" }, { "sim":1.0, - "partner":"6g6c" + "partner":"6g66" }, { - "sim":0.9987000227, - "partner":"6g65" + "sim":0.9599000216, + "partner":"6yaz" }, { - "sim":1.0, - "partner":"6g67" + "sim":0.9983999729, + "partner":"7boa" }, { - "sim":0.9966999888, - "partner":"6g6d" + "sim":0.9926000237, + "partner":"7bau" }, { - "sim":0.9769999981, - "partner":"6yb0" + "sim":1.0, + "partner":"4pn8" }, { "sim":0.9789999723, @@ -367331,25 +368593,13 @@ "sim":0.9787999988, "partner":"7bo8" }, - { - "sim":1.0, - "partner":"6g66" - }, { "sim":0.9826999903, "partner":"6g69" }, { - "sim":0.9983999729, - "partner":"7boa" - }, - { - "sim":1.0, - "partner":"4pn8" - }, - { - "sim":0.9599000216, - "partner":"6yaz" + "sim":0.9548000097, + "partner":"9gf2" }, { "sim":0.9894000292, @@ -367448,99 +368698,99 @@ ], "subtitle":"Moevan: a designed granulopoietic protein by topological rescaffolding", "tags":[ - "gcsf mimic", - "receptor modulator", "de novo protein", - "protein design" + "protein design", + "gcsf mimic", + "receptor modulator" ], "keywords":[ - "work", - "monomeric", - "potent", + "granulopoietic", + "purely", + "engineering", + "interestingly", + "methods", + "delayed", + "eliminating", + "rapidly", + "within", + "topological", + "stem", "strategy", - "receptor", - "hematopoietic", + "protein", + "rescaffolding", + "vitro", + "differentiation", + "cells", + "proliferative", + "line", "induced", - "methods", + "stable", + "proliferation", + "mature", + "using", + "receptor", + "goal", + "exhibited", "experimentally", - "determined", - "based", - "similarity", + "streamline", + "optimization", + "folded", "granulocytes", - "leads", - "primary", - "novel", - "therapeutic", - "utility", - "develop", - "proliferative", + "approach", + "bound", "proteins", - "models", - "exhibited", - "greatly", - "cell", - "\u00e5", - "rapidly", - "less", - "goal", + "develop", + "accuracy", + "2", + "factor", "highly", - "mature", + "hematopoietic", + "computational", + "set", + "lack", + "need", + "agents", + "design", "simpler", - "agreed", + "work", + "active", + "natural", + "empirical", + "tested", + "leads", + "also", + "therapeutic", + "cell", + "utility", + "primary", "highlighting", - "vitro", + "sequence", + "laboratory", + "achieving", + "agreed", + "models", + "counterpart", "improving", - "folded", "structures", - "granulopoietic", - "empirical", - "natural", - "differentiation", - "need", + "based", + "\u00e5", + "monomeric", + "determined", "powerful", - "streamline", - "optimization", - "delayed", "4", "would", - "active", - "granulocyte", + "becoming", + "greatly", "activity", - "engineering", - "design", - "interestingly", - "agents", - "using", - "stem", - "proliferation", - "eliminating", - "sequence", - "cells", - "accuracy", - "laboratory", - "factor", - "rescaffolding", - "designs", + "granulocyte", "despite", - "tested", - "line", - "lack", - "also", - "approach", - "stable", - "purely", + "potent", "human", - "topological", - "counterpart", - "set", - "achieving", - "significant", - "protein", - "bound", - "2", - "within", - "computational", - "becoming" + "designs", + "similarity", + "less", + "novel", + "significant" ], "release_date":"2020-03-18", "publication":"\"Design of novel granulopoietic proteins by topological rescaffolding\", Plos Biol., 18, e3000919-e3000919", @@ -367609,19 +368859,19 @@ }, { "sim":50.0, - "partner":"5dns" + "partner":"5dn0" }, { "sim":50.0, - "partner":"5dn0" + "partner":"5dns" }, { "sim":50.0, - "partner":"5dzb" + "partner":"4yfo" }, { "sim":50.0, - "partner":"4yfo" + "partner":"5dzb" }, { "sim":50.0, @@ -367665,10 +368915,6 @@ "sim":56.0, "partner":"6k67" }, - { - "sim":56.0, - "partner":"3rg6" - }, { "sim":56.0, "partner":"2wvw" @@ -367681,6 +368927,10 @@ "sim":56.0, "partner":"2peo" }, + { + "sim":56.0, + "partner":"3rg6" + }, { "sim":56.0, "partner":"1r9g" @@ -367843,23 +369093,15 @@ }, { "sim":54.0, - "partner":"3jq9" - }, - { - "sim":54.0, - "partner":"4cm3" - }, - { - "sim":54.0, - "partner":"4cmb" + "partner":"2yhi" }, { "sim":54.0, - "partner":"5jcj" + "partner":"3bmc" }, { "sim":54.0, - "partner":"6gdp" + "partner":"3jqa" }, { "sim":54.0, @@ -367871,35 +369113,31 @@ }, { "sim":54.0, - "partner":"6gcl" - }, - { - "sim":54.0, - "partner":"2yhi" + "partner":"4cm4" }, { "sim":54.0, - "partner":"3bmc" + "partner":"4cmc" }, { "sim":54.0, - "partner":"4cm4" + "partner":"5jcj" }, { "sim":54.0, - "partner":"4cmc" + "partner":"5k6a" }, { "sim":54.0, - "partner":"5k6a" + "partner":"6gcp" }, { "sim":54.0, - "partner":"3jqa" + "partner":"6gcq" }, { "sim":54.0, - "partner":"6gcp" + "partner":"6gd0" }, { "sim":54.0, @@ -367917,14 +369155,6 @@ "sim":54.0, "partner":"3jqb" }, - { - "sim":54.0, - "partner":"6gcq" - }, - { - "sim":54.0, - "partner":"6gd0" - }, { "sim":54.0, "partner":"4clr" @@ -367945,6 +369175,10 @@ "sim":54.0, "partner":"3jqc" }, + { + "sim":54.0, + "partner":"6gex" + }, { "sim":54.0, "partner":"2x9n" @@ -367965,10 +369199,6 @@ "sim":54.0, "partner":"4cmg" }, - { - "sim":54.0, - "partner":"6gex" - }, { "sim":54.0, "partner":"4cm7" @@ -367983,23 +369213,23 @@ }, { "sim":54.0, - "partner":"5jdi" + "partner":"6gey" }, { "sim":54.0, - "partner":"3gn2" + "partner":"6hnc" }, { "sim":54.0, - "partner":"4cle" + "partner":"5jdi" }, { "sim":54.0, - "partner":"6gey" + "partner":"3gn2" }, { "sim":54.0, - "partner":"6hnc" + "partner":"4cle" }, { "sim":54.0, @@ -368019,19 +369249,19 @@ }, { "sim":54.0, - "partner":"2x9v" + "partner":"6gd4" }, { "sim":54.0, - "partner":"4cmi" + "partner":"2x9v" }, { "sim":54.0, - "partner":"5jcx" + "partner":"4cmi" }, { "sim":54.0, - "partner":"6gd4" + "partner":"5jcx" }, { "sim":54.0, @@ -368049,6 +369279,10 @@ "sim":54.0, "partner":"3jqf" }, + { + "sim":54.0, + "partner":"6hnr" + }, { "sim":54.0, "partner":"4cmj" @@ -368067,7 +369301,7 @@ }, { "sim":54.0, - "partner":"6hnr" + "partner":"6how" }, { "sim":54.0, @@ -368077,6 +369311,10 @@ "sim":54.0, "partner":"5djh" }, + { + "sim":54.0, + "partner":"6gdo" + }, { "sim":54.0, "partner":"2x9g" @@ -368099,23 +369337,35 @@ }, { "sim":54.0, - "partner":"6how" + "partner":"4cmk" }, { "sim":54.0, - "partner":"4cmk" + "partner":"5djj" }, { "sim":54.0, - "partner":"5djj" + "partner":"5djk" }, { "sim":54.0, - "partner":"6gdo" + "partner":"4cm3" }, { "sim":54.0, - "partner":"5djk" + "partner":"4cmb" + }, + { + "sim":54.0, + "partner":"6gdp" + }, + { + "sim":54.0, + "partner":"3jq9" + }, + { + "sim":54.0, + "partner":"6gcl" }, { "sim":54.0, @@ -368127,11 +369377,11 @@ }, { "sim":54.0, - "partner":"6sf5" + "partner":"6sf4" }, { "sim":54.0, - "partner":"6sf4" + "partner":"6sf5" }, { "sim":54.0, @@ -368171,11 +369421,11 @@ }, { "sim":54.0, - "partner":"4gpu" + "partner":"4gps" }, { "sim":54.0, - "partner":"4gps" + "partner":"4gpu" }, { "sim":54.0, @@ -368349,10 +369599,6 @@ "sim":53.0, "partner":"2h34" }, - { - "sim":53.0, - "partner":"3g3d" - }, { "sim":53.0, "partner":"3bvj" @@ -368371,23 +369617,19 @@ }, { "sim":53.0, - "partner":"6oxh" - }, - { - "sim":53.0, - "partner":"4dmz" + "partner":"3g3d" }, { "sim":53.0, - "partner":"4dn0" + "partner":"6oxh" }, { "sim":53.0, - "partner":"3tmc" + "partner":"4dmz" }, { "sim":53.0, - "partner":"3tmd" + "partner":"4dn0" }, { "sim":53.0, @@ -368411,27 +369653,27 @@ }, { "sim":53.0, - "partner":"5y1g" + "partner":"3tmc" }, { "sim":53.0, - "partner":"5lor" + "partner":"5y1g" }, { "sim":53.0, - "partner":"5lou" + "partner":"3tmd" }, { "sim":53.0, - "partner":"6djt" + "partner":"5lor" }, { "sim":53.0, - "partner":"5tyq" + "partner":"5lou" }, { "sim":53.0, - "partner":"5u19" + "partner":"6djt" }, { "sim":53.0, @@ -368451,12 +369693,20 @@ }, { "sim":53.0, - "partner":"3wcf" + "partner":"5tyq" + }, + { + "sim":53.0, + "partner":"5u19" }, { "sim":53.0, "partner":"3wc9" }, + { + "sim":53.0, + "partner":"3wcf" + }, { "sim":53.0, "partner":"3wcl" @@ -368503,15 +369753,15 @@ }, { "sim":53.0, - "partner":"2iua" + "partner":"2iu8" }, { "sim":53.0, - "partner":"2iu8" + "partner":"2iu9" }, { "sim":53.0, - "partner":"2iu9" + "partner":"2iua" }, { "sim":53.0, @@ -368779,31 +370029,31 @@ }, { "sim":52.0, - "partner":"6ihr" + "partner":"6ihv" }, { "sim":52.0, - "partner":"6iht" + "partner":"6ihw" }, { "sim":52.0, - "partner":"6ihu" + "partner":"6ihr" }, { "sim":52.0, - "partner":"6ihv" + "partner":"6iht" }, { "sim":52.0, - "partner":"6ihw" + "partner":"6ihu" }, { "sim":52.0, - "partner":"5tii" + "partner":"5thq" }, { "sim":52.0, - "partner":"5thq" + "partner":"5tii" }, { "sim":52.0, @@ -368871,15 +370121,15 @@ }, { "sim":52.0, - "partner":"5zm4" + "partner":"5zm2" }, { "sim":52.0, - "partner":"5zm2" + "partner":"5zm3" }, { "sim":52.0, - "partner":"5zm3" + "partner":"5zm4" }, { "sim":52.0, @@ -368895,15 +370145,15 @@ }, { "sim":52.0, - "partner":"6l3w" + "partner":"6nok" }, { "sim":52.0, - "partner":"6nok" + "partner":"6dke" }, { "sim":52.0, - "partner":"6dke" + "partner":"6l3w" }, { "sim":52.0, @@ -368931,15 +370181,15 @@ }, { "sim":52.0, - "partner":"5exi" + "partner":"5exk" }, { "sim":52.0, - "partner":"5exj" + "partner":"5exi" }, { "sim":52.0, - "partner":"5exk" + "partner":"5exj" }, { "sim":52.0, @@ -368957,10 +370207,6 @@ "sim":52.0, "partner":"4mfz" }, - { - "sim":52.0, - "partner":"3uzz" - }, { "sim":52.0, "partner":"3g1r" @@ -368989,6 +370235,10 @@ "sim":52.0, "partner":"3uzy" }, + { + "sim":52.0, + "partner":"3uzz" + }, { "sim":52.0, "partner":"2c3f" @@ -369013,21 +370263,17 @@ "sim":52.0, "partner":"3mvj" }, - { - "sim":52.0, - "partner":"5ta7" - }, { "sim":52.0, "partner":"5ta9" }, { "sim":52.0, - "partner":"6p5r" + "partner":"5ta7" }, { "sim":52.0, - "partner":"4euh" + "partner":"6p5r" }, { "sim":52.0, @@ -369039,15 +370285,15 @@ }, { "sim":52.0, - "partner":"6hr5" + "partner":"4euh" }, { "sim":52.0, - "partner":"4qyj" + "partner":"6hr5" }, { "sim":52.0, - "partner":"2cj9" + "partner":"4qyj" }, { "sim":52.0, @@ -369061,6 +370307,10 @@ "sim":52.0, "partner":"2cjb" }, + { + "sim":52.0, + "partner":"2cj9" + }, { "sim":52.0, "partner":"3n6r" @@ -369171,11 +370421,11 @@ }, { "sim":51.0, - "partner":"3m9a" + "partner":"3m8e" }, { "sim":51.0, - "partner":"3m8e" + "partner":"3m9a" }, { "sim":51.0, @@ -369199,15 +370449,15 @@ }, { "sim":51.0, - "partner":"3qna" + "partner":"3qn0" }, { "sim":51.0, - "partner":"3qn0" + "partner":"3qn9" }, { "sim":51.0, - "partner":"3qn9" + "partner":"3qna" }, { "sim":51.0, @@ -369225,10 +370475,6 @@ "sim":51.0, "partner":"4qxz" }, - { - "sim":51.0, - "partner":"1vb6" - }, { "sim":51.0, "partner":"1v9y" @@ -369245,6 +370491,10 @@ "sim":51.0, "partner":"4yr8" }, + { + "sim":51.0, + "partner":"1vb6" + }, { "sim":51.0, "partner":"5x9k" @@ -369259,19 +370509,19 @@ }, { "sim":51.0, - "partner":"1x24" + "partner":"1zcl" }, { "sim":51.0, - "partner":"1zcl" + "partner":"1x24" }, { "sim":51.0, - "partner":"5k24" + "partner":"5k22" }, { "sim":51.0, - "partner":"5k22" + "partner":"5k24" }, { "sim":51.0, @@ -369285,10 +370535,6 @@ "sim":51.0, "partner":"2x7m" }, - { - "sim":51.0, - "partner":"5wg9" - }, { "sim":51.0, "partner":"5wap" @@ -369395,15 +370641,15 @@ }, { "sim":51.0, - "partner":"2j8k" + "partner":"5wg9" }, { "sim":51.0, - "partner":"2gee" + "partner":"2j8k" }, { "sim":51.0, - "partner":"3th5" + "partner":"2gee" }, { "sim":51.0, @@ -369415,15 +370661,15 @@ }, { "sim":51.0, - "partner":"1t57" + "partner":"3th5" }, { "sim":51.0, - "partner":"3vwv" + "partner":"1t57" }, { "sim":51.0, - "partner":"3l1u" + "partner":"3vwv" }, { "sim":51.0, @@ -369441,6 +370687,10 @@ "sim":51.0, "partner":"3esr" }, + { + "sim":51.0, + "partner":"3l1u" + }, { "sim":51.0, "partner":"2l22" @@ -369451,11 +370701,11 @@ }, { "sim":51.0, - "partner":"3oci" + "partner":"3oc3" }, { "sim":51.0, - "partner":"3oc3" + "partner":"3oci" }, { "sim":51.0, @@ -369467,15 +370717,15 @@ }, { "sim":51.0, - "partner":"5n7o" + "partner":"6hry" }, { "sim":51.0, - "partner":"6hry" + "partner":"5n7o" }, { "sim":51.0, - "partner":"1dto" + "partner":"6hrz" }, { "sim":51.0, @@ -369483,15 +370733,15 @@ }, { "sim":51.0, - "partner":"6hrz" + "partner":"6hs0" }, { "sim":51.0, - "partner":"6hs0" + "partner":"6hs1" }, { "sim":51.0, - "partner":"6hs1" + "partner":"1dto" }, { "sim":51.0, @@ -369513,17 +370763,13 @@ "sim":51.0, "partner":"4wqo" }, - { - "sim":51.0, - "partner":"2fz4" - }, { "sim":51.0, "partner":"2qhs" }, { "sim":51.0, - "partner":"5cvd" + "partner":"2fz4" }, { "sim":51.0, @@ -369533,6 +370779,10 @@ "sim":51.0, "partner":"2q7f" }, + { + "sim":51.0, + "partner":"5cvd" + }, { "sim":51.0, "partner":"4v0t" @@ -369553,10 +370803,6 @@ "sim":51.0, "partner":"2wbm" }, - { - "sim":51.0, - "partner":"4be6" - }, { "sim":51.0, "partner":"6azq" @@ -369589,6 +370835,10 @@ "sim":51.0, "partner":"4be5" }, + { + "sim":51.0, + "partner":"4be6" + }, { "sim":51.0, "partner":"1ig3" @@ -369643,19 +370893,15 @@ }, { "sim":51.0, - "partner":"6fcn" - }, - { - "sim":51.0, - "partner":"2wk1" + "partner":"6fcm" }, { "sim":51.0, - "partner":"6fcm" + "partner":"6fcn" }, { "sim":51.0, - "partner":"4bwa" + "partner":"2wk1" }, { "sim":51.0, @@ -369737,6 +370983,10 @@ "sim":51.0, "partner":"4bw9" }, + { + "sim":51.0, + "partner":"4bwa" + }, { "sim":51.0, "partner":"5y7x" @@ -369775,11 +371025,11 @@ }, { "sim":51.0, - "partner":"3ta4" + "partner":"3t9w" }, { "sim":51.0, - "partner":"3t9w" + "partner":"3ta4" }, { "sim":51.0, @@ -369817,10 +371067,6 @@ "sim":51.0, "partner":"6f26" }, - { - "sim":51.0, - "partner":"3u3r" - }, { "sim":51.0, "partner":"6l86" @@ -369837,6 +371083,10 @@ "sim":51.0, "partner":"3u3o" }, + { + "sim":51.0, + "partner":"3u3r" + }, { "sim":51.0, "partner":"5b6i" @@ -369953,14 +371203,6 @@ "sim":51.0, "partner":"3il5" }, - { - "sim":51.0, - "partner":"5glm" - }, - { - "sim":51.0, - "partner":"5gln" - }, { "sim":51.0, "partner":"5glo" @@ -369987,35 +371229,27 @@ }, { "sim":51.0, - "partner":"3a5y" - }, - { - "sim":51.0, - "partner":"5hs4" - }, - { - "sim":51.0, - "partner":"5hto" + "partner":"5glm" }, { "sim":51.0, - "partner":"5hru" + "partner":"5gln" }, { "sim":51.0, - "partner":"1t9s" + "partner":"3a5y" }, { "sim":51.0, - "partner":"3sie" + "partner":"5hs4" }, { "sim":51.0, - "partner":"4g2w" + "partner":"5hto" }, { "sim":51.0, - "partner":"4g2y" + "partner":"5hru" }, { "sim":51.0, @@ -370067,7 +371301,19 @@ }, { "sim":51.0, - "partner":"5zkj" + "partner":"3sie" + }, + { + "sim":51.0, + "partner":"1t9s" + }, + { + "sim":51.0, + "partner":"4g2w" + }, + { + "sim":51.0, + "partner":"4g2y" }, { "sim":51.0, @@ -370079,11 +371325,11 @@ }, { "sim":51.0, - "partner":"3ren" + "partner":"5zkj" }, { "sim":51.0, - "partner":"5l9l" + "partner":"3ren" }, { "sim":51.0, @@ -370105,6 +371351,10 @@ "sim":51.0, "partner":"5l9i" }, + { + "sim":51.0, + "partner":"5l9l" + }, { "sim":51.0, "partner":"2pvh" @@ -370157,10 +371407,6 @@ "sim":51.0, "partner":"5gov" }, - { - "sim":51.0, - "partner":"4m1i" - }, { "sim":51.0, "partner":"4d8f" @@ -370173,6 +371419,10 @@ "sim":51.0, "partner":"4m1h" }, + { + "sim":51.0, + "partner":"4m1i" + }, { "sim":51.0, "partner":"6cdf" @@ -370213,14 +371463,6 @@ "sim":51.0, "partner":"4rzt" }, - { - "sim":51.0, - "partner":"4q3r" - }, - { - "sim":51.0, - "partner":"4q42" - }, { "sim":51.0, "partner":"4q3s" @@ -370255,7 +371497,11 @@ }, { "sim":51.0, - "partner":"5hxu" + "partner":"4q3r" + }, + { + "sim":51.0, + "partner":"4q42" }, { "sim":51.0, @@ -370269,6 +371515,10 @@ "sim":51.0, "partner":"5hwe" }, + { + "sim":51.0, + "partner":"5hxu" + }, { "sim":51.0, "partner":"6a4i" @@ -370323,11 +371573,11 @@ }, { "sim":51.0, - "partner":"3wkr" + "partner":"3wks" }, { "sim":51.0, - "partner":"3wks" + "partner":"3wkr" }, { "sim":51.0, @@ -370369,10 +371619,6 @@ "sim":51.0, "partner":"5kyo" }, - { - "sim":51.0, - "partner":"4q6q" - }, { "sim":51.0, "partner":"4q6m" @@ -370391,15 +371637,15 @@ }, { "sim":51.0, - "partner":"3c48" + "partner":"4q6q" }, { "sim":51.0, - "partner":"4kp2" + "partner":"3c48" }, { "sim":51.0, - "partner":"2imc" + "partner":"4kp2" }, { "sim":51.0, @@ -370427,19 +371673,19 @@ }, { "sim":51.0, - "partner":"5xwb" + "partner":"2imc" }, { "sim":51.0, - "partner":"8vwk" + "partner":"5xwb" }, { "sim":51.0, - "partner":"4ine" + "partner":"8vwk" }, { "sim":51.0, - "partner":"2r98" + "partner":"4ine" }, { "sim":51.0, @@ -370463,11 +371709,11 @@ }, { "sim":51.0, - "partner":"6iyo" + "partner":"2r98" }, { "sim":51.0, - "partner":"6oi8" + "partner":"6iyo" }, { "sim":51.0, @@ -370507,7 +371753,7 @@ }, { "sim":51.0, - "partner":"6ak4" + "partner":"6oi8" }, { "sim":51.0, @@ -370515,11 +371761,11 @@ }, { "sim":51.0, - "partner":"2fwr" + "partner":"6ak4" }, { "sim":51.0, - "partner":"5v59" + "partner":"2fwr" }, { "sim":51.0, @@ -370531,7 +371777,7 @@ }, { "sim":51.0, - "partner":"5uno" + "partner":"5v59" }, { "sim":51.0, @@ -370547,7 +371793,7 @@ }, { "sim":51.0, - "partner":"4ie7" + "partner":"5uno" }, { "sim":51.0, @@ -370589,6 +371835,10 @@ "sim":51.0, "partner":"4qho" }, + { + "sim":51.0, + "partner":"4ie7" + }, { "sim":51.0, "partner":"3mje" @@ -370625,10 +371875,6 @@ "sim":51.0, "partner":"3mjc" }, - { - "sim":51.0, - "partner":"6qu3" - }, { "sim":51.0, "partner":"6qu4" @@ -370643,7 +371889,7 @@ }, { "sim":51.0, - "partner":"1zdl" + "partner":"6qu3" }, { "sim":51.0, @@ -370651,19 +371897,15 @@ }, { "sim":51.0, - "partner":"5y6l" - }, - { - "sim":51.0, - "partner":"4j15" + "partner":"1zdl" }, { "sim":51.0, - "partner":"4ids" + "partner":"5y6l" }, { "sim":51.0, - "partner":"4jdc" + "partner":"4j15" }, { "sim":51.0, @@ -370683,7 +371925,11 @@ }, { "sim":51.0, - "partner":"2q5l" + "partner":"4ids" + }, + { + "sim":51.0, + "partner":"4jdc" }, { "sim":51.0, @@ -370703,15 +371949,15 @@ }, { "sim":51.0, - "partner":"3rde" + "partner":"2q5l" }, { "sim":51.0, - "partner":"4imp" + "partner":"3rde" }, { "sim":51.0, - "partner":"5tsh" + "partner":"4imp" }, { "sim":51.0, @@ -370727,11 +371973,11 @@ }, { "sim":51.0, - "partner":"6gng" + "partner":"5tsh" }, { "sim":51.0, - "partner":"6k8s" + "partner":"6gng" }, { "sim":51.0, @@ -370743,15 +371989,7 @@ }, { "sim":51.0, - "partner":"2yii" - }, - { - "sim":51.0, - "partner":"4c5s" - }, - { - "sim":51.0, - "partner":"4v2r" + "partner":"6k8s" }, { "sim":51.0, @@ -370777,10 +372015,22 @@ "sim":51.0, "partner":"4c5r" }, + { + "sim":51.0, + "partner":"2yii" + }, { "sim":51.0, "partner":"4v2q" }, + { + "sim":51.0, + "partner":"4c5s" + }, + { + "sim":51.0, + "partner":"4v2r" + }, { "sim":51.0, "partner":"5x7g" @@ -370937,10 +372187,6 @@ "sim":50.0, "partner":"3t8y" }, - { - "sim":50.0, - "partner":"2vbq" - }, { "sim":50.0, "partner":"1s3z" @@ -370953,6 +372199,10 @@ "sim":50.0, "partner":"1s60" }, + { + "sim":50.0, + "partner":"2vbq" + }, { "sim":50.0, "partner":"4nex" @@ -370987,7 +372237,7 @@ }, { "sim":50.0, - "partner":"5edd" + "partner":"8p8o" }, { "sim":50.0, @@ -371025,10 +372275,6 @@ "sim":50.0, "partner":"2i7a" }, - { - "sim":50.0, - "partner":"8p8o" - }, { "sim":50.0, "partner":"1sm8" @@ -371043,16 +372289,20 @@ }, { "sim":50.0, - "partner":"3q93" + "partner":"5edd" }, { "sim":50.0, - "partner":"4gzc" + "partner":"3q93" }, { "sim":50.0, "partner":"4gzd" }, + { + "sim":50.0, + "partner":"4gzc" + }, { "sim":50.0, "partner":"6kz6" @@ -371083,11 +372333,11 @@ }, { "sim":50.0, - "partner":"6f3z" + "partner":"6fhm" }, { "sim":50.0, - "partner":"6fhm" + "partner":"6f3z" }, { "sim":50.0, @@ -371097,10 +372347,6 @@ "sim":50.0, "partner":"5j1k" }, - { - "sim":50.0, - "partner":"2fzl" - }, { "sim":50.0, "partner":"2q16" @@ -371113,6 +372359,10 @@ "sim":50.0, "partner":"5f51" }, + { + "sim":50.0, + "partner":"2fzl" + }, { "sim":50.0, "partner":"4mh3" @@ -371173,14 +372423,6 @@ "sim":50.0, "partner":"3r6s" }, - { - "sim":50.0, - "partner":"3ft5" - }, - { - "sim":50.0, - "partner":"2xdx" - }, { "sim":50.0, "partner":"3ft8" @@ -371249,6 +372491,14 @@ "sim":50.0, "partner":"2xhx" }, + { + "sim":50.0, + "partner":"3ft5" + }, + { + "sim":50.0, + "partner":"2xdx" + }, { "sim":50.0, "partner":"1s9q" @@ -371295,11 +372545,11 @@ }, { "sim":50.0, - "partner":"6ey1" + "partner":"6f0w" }, { "sim":50.0, - "partner":"6f0w" + "partner":"6ey1" }, { "sim":50.0, @@ -371317,10 +372567,6 @@ "sim":50.0, "partner":"5du0" }, - { - "sim":50.0, - "partner":"4jyi" - }, { "sim":50.0, "partner":"4dm6" @@ -371345,6 +372591,10 @@ "sim":50.0, "partner":"4jyh" }, + { + "sim":50.0, + "partner":"4jyi" + }, { "sim":50.0, "partner":"4qts" @@ -371451,11 +372701,11 @@ }, { "sim":50.0, - "partner":"6iqs" + "partner":"6iqq" }, { "sim":50.0, - "partner":"6iqq" + "partner":"6iqs" }, { "sim":50.0, @@ -371519,15 +372769,15 @@ }, { "sim":50.0, - "partner":"2oau" + "partner":"6uzh" }, { "sim":50.0, - "partner":"4hwa" + "partner":"2oau" }, { "sim":50.0, - "partner":"6uzh" + "partner":"4hwa" }, { "sim":50.0, @@ -371549,10 +372799,6 @@ "sim":50.0, "partner":"2qj3" }, - { - "sim":50.0, - "partner":"3aio" - }, { "sim":50.0, "partner":"3aik" @@ -371569,6 +372815,10 @@ "sim":50.0, "partner":"3ain" }, + { + "sim":50.0, + "partner":"3aio" + }, { "sim":50.0, "partner":"4xrw" @@ -371617,10 +372867,6 @@ "sim":50.0, "partner":"6fu4" }, - { - "sim":50.0, - "partner":"3mey" - }, { "sim":50.0, "partner":"3pzc" @@ -371635,91 +372881,91 @@ }, { "sim":50.0, - "partner":"1xoq" + "partner":"3mey" }, { "sim":50.0, - "partner":"6ind" + "partner":"1y2b" }, { "sim":50.0, - "partner":"1xor" + "partner":"6imt" }, { "sim":50.0, - "partner":"3iak" + "partner":"1y2c" }, { "sim":50.0, - "partner":"6imr" + "partner":"6ink" }, { "sim":50.0, - "partner":"1y2b" + "partner":"1y2d" }, { "sim":50.0, - "partner":"6im6" + "partner":"1y2e" }, { "sim":50.0, - "partner":"6imt" + "partner":"6inm" }, { "sim":50.0, - "partner":"1y2c" + "partner":"6imb" }, { "sim":50.0, - "partner":"1y2d" + "partner":"6imd" }, { "sim":50.0, - "partner":"6ink" + "partner":"1y2k" }, { "sim":50.0, - "partner":"1y2e" + "partner":"6imi" }, { "sim":50.0, - "partner":"6inm" + "partner":"6imo" }, { "sim":50.0, - "partner":"6imb" + "partner":"1xom" }, { "sim":50.0, - "partner":"6imd" + "partner":"1xon" }, { "sim":50.0, - "partner":"1y2k" + "partner":"3k4s" }, { "sim":50.0, - "partner":"1xom" + "partner":"6ind" }, { "sim":50.0, - "partner":"6imi" + "partner":"1xoq" }, { "sim":50.0, - "partner":"6imo" + "partner":"6imr" }, { "sim":50.0, - "partner":"1xon" + "partner":"1xor" }, { "sim":50.0, - "partner":"3k4s" + "partner":"6im6" }, { "sim":50.0, - "partner":"2ikf" + "partner":"3iak" }, { "sim":50.0, @@ -371739,11 +372985,11 @@ }, { "sim":50.0, - "partner":"2q0e" + "partner":"6gpn" }, { "sim":50.0, - "partner":"6gpn" + "partner":"2q0e" }, { "sim":50.0, @@ -371771,11 +373017,11 @@ }, { "sim":50.0, - "partner":"5kal" + "partner":"6hl8" }, { "sim":50.0, - "partner":"6hl8" + "partner":"5kal" }, { "sim":50.0, @@ -371787,7 +373033,11 @@ }, { "sim":50.0, - "partner":"6pi5" + "partner":"2ikf" + }, + { + "sim":50.0, + "partner":"6pi6" }, { "sim":50.0, @@ -371795,7 +373045,7 @@ }, { "sim":50.0, - "partner":"6pi6" + "partner":"6pi5" }, { "sim":50.0, @@ -371835,19 +373085,19 @@ }, { "sim":50.0, - "partner":"6fm0" + "partner":"6fm3" }, { "sim":50.0, - "partner":"6fko" + "partner":"6flf" }, { "sim":50.0, - "partner":"6fm3" + "partner":"6fm0" }, { "sim":50.0, - "partner":"6flf" + "partner":"6fko" }, { "sim":50.0, @@ -371881,22 +373131,6 @@ "sim":50.0, "partner":"5xnh" }, - { - "sim":50.0, - "partner":"5zzx" - }, - { - "sim":50.0, - "partner":"6a0d" - }, - { - "sim":50.0, - "partner":"5zzy" - }, - { - "sim":50.0, - "partner":"6a0v" - }, { "sim":50.0, "partner":"5zzz" @@ -372039,31 +373273,39 @@ }, { "sim":50.0, - "partner":"1pme" + "partner":"5zzx" }, { "sim":50.0, - "partner":"4gmg" + "partner":"6a0d" }, { "sim":50.0, - "partner":"5kvq" + "partner":"5zzy" }, { "sim":50.0, - "partner":"5kvs" + "partner":"6a0v" }, { "sim":50.0, - "partner":"5a7v" + "partner":"1pme" }, { "sim":50.0, - "partner":"3dyh" + "partner":"4gmg" }, { "sim":50.0, - "partner":"4rxd" + "partner":"5kvq" + }, + { + "sim":50.0, + "partner":"5kvs" + }, + { + "sim":50.0, + "partner":"5a7v" }, { "sim":50.0, @@ -372105,6 +373347,14 @@ "sim":50.0, "partner":"3dyg" }, + { + "sim":50.0, + "partner":"4rxd" + }, + { + "sim":50.0, + "partner":"3dyh" + }, { "sim":50.0, "partner":"2qdh" @@ -372175,15 +373425,15 @@ }, { "sim":50.0, - "partner":"5z8a" + "partner":"5z8k" }, { "sim":50.0, - "partner":"5z8k" + "partner":"5z83" }, { "sim":50.0, - "partner":"5z83" + "partner":"5z8a" }, { "sim":50.0, @@ -372267,11 +373517,11 @@ }, { "sim":50.0, - "partner":"3hzz" + "partner":"6qps" }, { "sim":50.0, - "partner":"6qps" + "partner":"3hzz" }, { "sim":50.0, @@ -372293,10 +373543,6 @@ "sim":50.0, "partner":"6s54" }, - { - "sim":50.0, - "partner":"6rk2" - }, { "sim":50.0, "partner":"6rjo" @@ -372309,6 +373555,10 @@ "sim":50.0, "partner":"6rjm" }, + { + "sim":50.0, + "partner":"6rk2" + }, { "sim":50.0, "partner":"4v1x" @@ -372383,11 +373633,11 @@ }, { "sim":50.0, - "partner":"4gyk" + "partner":"4gyj" }, { "sim":50.0, - "partner":"4gyj" + "partner":"4gyk" }, { "sim":50.0, @@ -372421,10 +373671,6 @@ "sim":50.0, "partner":"6qbf" }, - { - "sim":50.0, - "partner":"5t4a" - }, { "sim":50.0, "partner":"5t4c" @@ -372435,7 +373681,7 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"5t4a" }, { "sim":50.0, @@ -372445,6 +373691,10 @@ "sim":50.0, "partner":"6ee1" }, + { + "sim":50.0, + "partner":"6edw" + }, { "sim":50.0, "partner":"5zi5" @@ -372560,99 +373810,99 @@ ], "subtitle":"Designing a granulopoietic protein by topological rescaffolding 1: sohair", "tags":[ - "gcsf analog", - "receptor modulator", "de novo protein", - "protein design" + "protein design", + "gcsf analog", + "receptor modulator" ], "keywords":[ - "work", - "monomeric", - "potent", + "granulopoietic", + "purely", + "engineering", + "interestingly", + "methods", + "delayed", + "eliminating", + "rapidly", + "within", + "topological", + "stem", "strategy", - "receptor", - "hematopoietic", + "protein", + "rescaffolding", + "vitro", + "differentiation", + "cells", + "proliferative", + "line", "induced", - "methods", + "stable", + "proliferation", + "mature", + "using", + "receptor", + "goal", + "exhibited", "experimentally", - "determined", - "based", - "similarity", + "streamline", + "optimization", + "folded", "granulocytes", - "leads", - "primary", - "novel", - "therapeutic", - "utility", - "develop", - "proliferative", + "approach", + "bound", "proteins", - "models", - "exhibited", - "greatly", - "cell", - "\u00e5", - "rapidly", - "less", - "goal", + "develop", + "accuracy", + "2", + "factor", "highly", - "mature", + "hematopoietic", + "computational", + "set", + "lack", + "need", + "agents", + "design", "simpler", - "agreed", + "work", + "active", + "natural", + "empirical", + "tested", + "leads", + "also", + "therapeutic", + "cell", + "utility", + "primary", "highlighting", - "vitro", + "sequence", + "laboratory", + "achieving", + "agreed", + "models", + "counterpart", "improving", - "folded", "structures", - "granulopoietic", - "empirical", - "natural", - "differentiation", - "need", + "based", + "\u00e5", + "monomeric", + "determined", "powerful", - "streamline", - "optimization", - "delayed", "4", "would", - "active", - "granulocyte", + "becoming", + "greatly", "activity", - "engineering", - "design", - "interestingly", - "agents", - "using", - "stem", - "proliferation", - "eliminating", - "sequence", - "cells", - "accuracy", - "laboratory", - "factor", - "rescaffolding", - "designs", + "granulocyte", "despite", - "tested", - "line", - "lack", - "also", - "approach", - "stable", - "purely", + "potent", "human", - "topological", - "counterpart", - "set", - "achieving", - "significant", - "protein", - "bound", - "2", - "within", - "computational", - "becoming" + "designs", + "similarity", + "less", + "novel", + "significant" ], "release_date":"2020-03-18", "publication":"\"Design of novel granulopoietic proteins by topological rescaffolding\", Plos Biol., 18, e3000919-e3000919", @@ -372737,19 +373987,19 @@ }, { "sim":52.0, - "partner":"5dns" + "partner":"5dn0" }, { "sim":52.0, - "partner":"5dn0" + "partner":"5dns" }, { "sim":52.0, - "partner":"5dzb" + "partner":"4yfo" }, { "sim":52.0, - "partner":"4yfo" + "partner":"5dzb" }, { "sim":51.0, @@ -372789,10 +374039,6 @@ "sim":67.0, "partner":"5xnh" }, - { - "sim":65.0, - "partner":"4d2w" - }, { "sim":65.0, "partner":"4d2p" @@ -372825,6 +374071,10 @@ "sim":65.0, "partner":"4d2v" }, + { + "sim":65.0, + "partner":"4d2w" + }, { "sim":64.0, "partner":"2q5r" @@ -372971,15 +374221,15 @@ }, { "sim":56.0, - "partner":"5kdn" + "partner":"5kds" }, { "sim":56.0, - "partner":"5kds" + "partner":"5kdu" }, { "sim":56.0, - "partner":"5kdu" + "partner":"5kdn" }, { "sim":56.0, @@ -373117,10 +374367,6 @@ "sim":55.0, "partner":"4h3h" }, - { - "sim":55.0, - "partner":"2iua" - }, { "sim":55.0, "partner":"2iu8" @@ -373131,11 +374377,11 @@ }, { "sim":55.0, - "partner":"3o2t" + "partner":"2iua" }, { "sim":55.0, - "partner":"4q6q" + "partner":"3o2t" }, { "sim":55.0, @@ -373153,6 +374399,10 @@ "sim":55.0, "partner":"4q6p" }, + { + "sim":55.0, + "partner":"4q6q" + }, { "sim":55.0, "partner":"2z67" @@ -373243,23 +374493,23 @@ }, { "sim":54.0, - "partner":"1x19" + "partner":"1x1b" }, { "sim":54.0, - "partner":"1x1a" + "partner":"1x1c" }, { "sim":54.0, - "partner":"1x1b" + "partner":"1x1d" }, { "sim":54.0, - "partner":"1x1c" + "partner":"1x19" }, { "sim":54.0, - "partner":"1x1d" + "partner":"1x1a" }, { "sim":54.0, @@ -373305,10 +374555,6 @@ "sim":53.0, "partner":"4pu8" }, - { - "sim":53.0, - "partner":"3qna" - }, { "sim":53.0, "partner":"3qn0" @@ -373325,6 +374571,10 @@ "sim":53.0, "partner":"3qn9" }, + { + "sim":53.0, + "partner":"3qna" + }, { "sim":53.0, "partner":"5wvc" @@ -373371,19 +374621,19 @@ }, { "sim":53.0, - "partner":"5n7o" + "partner":"6hry" }, { "sim":53.0, - "partner":"6hry" + "partner":"5n7o" }, { "sim":53.0, - "partner":"5n1c" + "partner":"6hrz" }, { "sim":53.0, - "partner":"6hrz" + "partner":"5n1c" }, { "sim":53.0, @@ -373445,10 +374695,6 @@ "sim":53.0, "partner":"2nsg" }, - { - "sim":53.0, - "partner":"1zw3" - }, { "sim":53.0, "partner":"1zvz" @@ -373459,15 +374705,11 @@ }, { "sim":53.0, - "partner":"4iv0" - }, - { - "sim":53.0, - "partner":"3quo" + "partner":"1zw3" }, { "sim":53.0, - "partner":"3qvf" + "partner":"4iv0" }, { "sim":53.0, @@ -373491,15 +374733,19 @@ }, { "sim":53.0, - "partner":"3jyy" + "partner":"3quo" }, { "sim":53.0, - "partner":"3jz0" + "partner":"3qvf" }, { "sim":53.0, - "partner":"4rtl" + "partner":"3jyy" + }, + { + "sim":53.0, + "partner":"3jz0" }, { "sim":53.0, @@ -373541,6 +374787,10 @@ "sim":53.0, "partner":"4rtk" }, + { + "sim":53.0, + "partner":"4rtl" + }, { "sim":53.0, "partner":"4txc" @@ -373597,14 +374847,6 @@ "sim":53.0, "partner":"6hm2" }, - { - "sim":53.0, - "partner":"5gg5" - }, - { - "sim":53.0, - "partner":"5xd1" - }, { "sim":53.0, "partner":"5gg6" @@ -373653,6 +374895,14 @@ "sim":53.0, "partner":"5ggd" }, + { + "sim":53.0, + "partner":"5gg5" + }, + { + "sim":53.0, + "partner":"5xd1" + }, { "sim":53.0, "partner":"4ku2" @@ -373711,23 +374961,23 @@ }, { "sim":53.0, - "partner":"6fm0" + "partner":"6fm3" }, { "sim":53.0, - "partner":"6fko" + "partner":"6flf" }, { "sim":53.0, - "partner":"6fm1" + "partner":"6fm0" }, { "sim":53.0, - "partner":"6fm3" + "partner":"6fko" }, { "sim":53.0, - "partner":"6flf" + "partner":"6fm1" }, { "sim":53.0, @@ -373927,11 +375177,11 @@ }, { "sim":53.0, - "partner":"2ix0" + "partner":"1ry2" }, { "sim":53.0, - "partner":"1ry2" + "partner":"2ix0" }, { "sim":53.0, @@ -373947,15 +375197,15 @@ }, { "sim":53.0, - "partner":"6tsh" + "partner":"6tsk" }, { "sim":53.0, - "partner":"6tte" + "partner":"6tsh" }, { "sim":53.0, - "partner":"6tsk" + "partner":"6tte" }, { "sim":53.0, @@ -374055,15 +375305,15 @@ }, { "sim":52.0, - "partner":"3la7" + "partner":"3la2" }, { "sim":52.0, - "partner":"3la2" + "partner":"3la3" }, { "sim":52.0, - "partner":"3la3" + "partner":"3la7" }, { "sim":52.0, @@ -374151,11 +375401,11 @@ }, { "sim":52.0, - "partner":"6fcn" + "partner":"6fcm" }, { "sim":52.0, - "partner":"6fcm" + "partner":"6fcn" }, { "sim":52.0, @@ -374183,15 +375433,19 @@ }, { "sim":52.0, - "partner":"5uj3" + "partner":"8rwq" }, { "sim":52.0, - "partner":"5uj4" + "partner":"6mnp" }, { "sim":52.0, - "partner":"6mnp" + "partner":"8rwr" + }, + { + "sim":52.0, + "partner":"5uj3" }, { "sim":52.0, @@ -374199,7 +375453,11 @@ }, { "sim":52.0, - "partner":"5ul8" + "partner":"8rws" + }, + { + "sim":52.0, + "partner":"5uj4" }, { "sim":52.0, @@ -374213,6 +375471,10 @@ "sim":52.0, "partner":"6d17" }, + { + "sim":52.0, + "partner":"5ul8" + }, { "sim":52.0, "partner":"6d18" @@ -374245,10 +375507,6 @@ "sim":52.0, "partner":"6qwe" }, - { - "sim":52.0, - "partner":"8rwq" - }, { "sim":52.0, "partner":"6mey" @@ -374265,6 +375523,14 @@ "sim":52.0, "partner":"6td1" }, + { + "sim":52.0, + "partner":"8rwo" + }, + { + "sim":52.0, + "partner":"8rwp" + }, { "sim":52.0, "partner":"5y7x" @@ -374287,11 +375553,11 @@ }, { "sim":52.0, - "partner":"6iqs" + "partner":"6iqq" }, { "sim":52.0, - "partner":"6iqq" + "partner":"6iqs" }, { "sim":52.0, @@ -374387,15 +375653,15 @@ }, { "sim":52.0, - "partner":"4hcl" + "partner":"4hcd" }, { "sim":52.0, - "partner":"4hcd" + "partner":"4hch" }, { "sim":52.0, - "partner":"4hch" + "partner":"4hcl" }, { "sim":52.0, @@ -374429,10 +375695,6 @@ "sim":52.0, "partner":"3ods" }, - { - "sim":52.0, - "partner":"5d40" - }, { "sim":52.0, "partner":"6hr7" @@ -374445,6 +375707,10 @@ "sim":52.0, "partner":"5d3u" }, + { + "sim":52.0, + "partner":"5d40" + }, { "sim":52.0, "partner":"3r1k" @@ -374469,10 +375735,6 @@ "sim":52.0, "partner":"2rim" }, - { - "sim":52.0, - "partner":"5v1s" - }, { "sim":52.0, "partner":"5v1t" @@ -374483,7 +375745,7 @@ }, { "sim":52.0, - "partner":"6ak4" + "partner":"5v1s" }, { "sim":52.0, @@ -374491,7 +375753,7 @@ }, { "sim":52.0, - "partner":"4l2h" + "partner":"6ak4" }, { "sim":52.0, @@ -374501,6 +375763,10 @@ "sim":52.0, "partner":"4epq" }, + { + "sim":52.0, + "partner":"4l2h" + }, { "sim":52.0, "partner":"5kqw" @@ -374517,10 +375783,6 @@ "sim":52.0, "partner":"6akw" }, - { - "sim":52.0, - "partner":"4ie7" - }, { "sim":52.0, "partner":"4cxw" @@ -374563,15 +375825,15 @@ }, { "sim":52.0, - "partner":"6dt1" + "partner":"4ie7" }, { "sim":52.0, - "partner":"6a37" + "partner":"6dt1" }, { "sim":52.0, - "partner":"2q5l" + "partner":"6a37" }, { "sim":52.0, @@ -374589,6 +375851,10 @@ "sim":52.0, "partner":"2q5j" }, + { + "sim":52.0, + "partner":"2q5l" + }, { "sim":52.0, "partner":"5ahk" @@ -374801,10 +376067,6 @@ "sim":51.0, "partner":"3i93" }, - { - "sim":51.0, - "partner":"5hso" - }, { "sim":51.0, "partner":"5x7z" @@ -374819,19 +376081,19 @@ }, { "sim":51.0, - "partner":"1ehw" + "partner":"5hso" }, { "sim":51.0, - "partner":"5ect" + "partner":"1ehw" }, { "sim":51.0, - "partner":"6t73" + "partner":"5ect" }, { "sim":51.0, - "partner":"4evc" + "partner":"6t73" }, { "sim":51.0, @@ -374849,6 +376111,10 @@ "sim":51.0, "partner":"4evb" }, + { + "sim":51.0, + "partner":"4evc" + }, { "sim":51.0, "partner":"2mux" @@ -374867,7 +376133,7 @@ }, { "sim":51.0, - "partner":"5edd" + "partner":"8p8o" }, { "sim":51.0, @@ -374901,10 +376167,6 @@ "sim":51.0, "partner":"3loj" }, - { - "sim":51.0, - "partner":"8p8o" - }, { "sim":51.0, "partner":"1sm8" @@ -374921,6 +376183,10 @@ "sim":51.0, "partner":"3hza" }, + { + "sim":51.0, + "partner":"5edd" + }, { "sim":51.0, "partner":"2b6b" @@ -374943,11 +376209,11 @@ }, { "sim":51.0, - "partner":"4o8t" + "partner":"4o8l" }, { "sim":51.0, - "partner":"4o8l" + "partner":"4o8t" }, { "sim":51.0, @@ -375083,11 +376349,11 @@ }, { "sim":51.0, - "partner":"6o98" + "partner":"6bn6" }, { "sim":51.0, - "partner":"6bn6" + "partner":"6o98" }, { "sim":51.0, @@ -375097,10 +376363,6 @@ "sim":51.0, "partner":"3kmr" }, - { - "sim":51.0, - "partner":"4jyi" - }, { "sim":51.0, "partner":"4dm6" @@ -375125,6 +376387,10 @@ "sim":51.0, "partner":"4jyh" }, + { + "sim":51.0, + "partner":"4jyi" + }, { "sim":51.0, "partner":"5t65" @@ -375159,7 +376425,7 @@ }, { "sim":51.0, - "partner":"6hxo" + "partner":"6hxn" }, { "sim":51.0, @@ -375167,7 +376433,7 @@ }, { "sim":51.0, - "partner":"6hxn" + "partner":"6hxo" }, { "sim":51.0, @@ -375283,11 +376549,11 @@ }, { "sim":51.0, - "partner":"5lsg" + "partner":"6t9c" }, { "sim":51.0, - "partner":"6t9c" + "partner":"5lsg" }, { "sim":51.0, @@ -375345,14 +376611,6 @@ "sim":51.0, "partner":"6kd9" }, - { - "sim":51.0, - "partner":"3tmc" - }, - { - "sim":51.0, - "partner":"3tmd" - }, { "sim":51.0, "partner":"3tm8" @@ -375363,11 +376621,11 @@ }, { "sim":51.0, - "partner":"2nq6" + "partner":"3tmc" }, { "sim":51.0, - "partner":"2nq7" + "partner":"3tmd" }, { "sim":51.0, @@ -375407,11 +376665,11 @@ }, { "sim":51.0, - "partner":"5exi" + "partner":"2nq6" }, { "sim":51.0, - "partner":"5exj" + "partner":"2nq7" }, { "sim":51.0, @@ -375419,23 +376677,23 @@ }, { "sim":51.0, - "partner":"3auz" + "partner":"5exi" }, { "sim":51.0, - "partner":"3x27" + "partner":"5exj" }, { "sim":51.0, - "partner":"2f9y" + "partner":"3auz" }, { "sim":51.0, - "partner":"5tyq" + "partner":"3x27" }, { "sim":51.0, - "partner":"5u19" + "partner":"2f9y" }, { "sim":51.0, @@ -375453,6 +376711,14 @@ "sim":51.0, "partner":"5u1i" }, + { + "sim":51.0, + "partner":"5tyq" + }, + { + "sim":51.0, + "partner":"5u19" + }, { "sim":51.0, "partner":"2yhw" @@ -375467,27 +376733,27 @@ }, { "sim":51.0, - "partner":"4mfj" + "partner":"4mfl" }, { "sim":51.0, - "partner":"4mfk" + "partner":"4mfp" }, { "sim":51.0, - "partner":"4mfl" + "partner":"4mfq" }, { "sim":51.0, - "partner":"6iix" + "partner":"4mfj" }, { "sim":51.0, - "partner":"4mfp" + "partner":"6iix" }, { "sim":51.0, - "partner":"4mfq" + "partner":"4mfk" }, { "sim":51.0, @@ -375505,10 +376771,6 @@ "sim":51.0, "partner":"3ren" }, - { - "sim":51.0, - "partner":"2ikf" - }, { "sim":51.0, "partner":"2q0c" @@ -375537,6 +376799,10 @@ "sim":51.0, "partner":"5kal" }, + { + "sim":51.0, + "partner":"2ikf" + }, { "sim":51.0, "partner":"6ef6" @@ -375589,10 +376855,6 @@ "sim":51.0, "partner":"5ve3" }, - { - "sim":51.0, - "partner":"3c1y" - }, { "sim":51.0, "partner":"3c1z" @@ -375639,11 +376901,7 @@ }, { "sim":51.0, - "partner":"4q3r" - }, - { - "sim":51.0, - "partner":"4q42" + "partner":"3c1y" }, { "sim":51.0, @@ -375677,6 +376935,14 @@ "sim":51.0, "partner":"4q41" }, + { + "sim":51.0, + "partner":"4q3r" + }, + { + "sim":51.0, + "partner":"4q42" + }, { "sim":51.0, "partner":"3av0" @@ -375737,10 +377003,6 @@ "sim":51.0, "partner":"6ju1" }, - { - "sim":51.0, - "partner":"4lre" - }, { "sim":51.0, "partner":"4lrf" @@ -375775,12 +377037,16 @@ }, { "sim":51.0, - "partner":"4r33" + "partner":"4lre" }, { "sim":51.0, "partner":"4r34" }, + { + "sim":51.0, + "partner":"4r33" + }, { "sim":51.0, "partner":"3sxn" @@ -375877,10 +377143,6 @@ "sim":51.0, "partner":"5kr5" }, - { - "sim":51.0, - "partner":"6rk2" - }, { "sim":51.0, "partner":"6rjo" @@ -375893,6 +377155,10 @@ "sim":51.0, "partner":"6rjm" }, + { + "sim":51.0, + "partner":"6rk2" + }, { "sim":51.0, "partner":"3mje" @@ -375929,10 +377195,6 @@ "sim":51.0, "partner":"5gl5" }, - { - "sim":51.0, - "partner":"6bzn" - }, { "sim":51.0, "partner":"6bzz" @@ -375953,6 +377215,10 @@ "sim":51.0, "partner":"6bzi" }, + { + "sim":51.0, + "partner":"6bzn" + }, { "sim":51.0, "partner":"5z5e" @@ -376005,10 +377271,6 @@ "sim":51.0, "partner":"5uqn" }, - { - "sim":51.0, - "partner":"5wm2" - }, { "sim":51.0, "partner":"5wm3" @@ -376031,12 +377293,16 @@ }, { "sim":51.0, - "partner":"2vbg" + "partner":"5wm2" }, { "sim":51.0, "partner":"2vbf" }, + { + "sim":51.0, + "partner":"2vbg" + }, { "sim":51.0, "partner":"6dqw" @@ -376065,10 +377331,6 @@ "sim":51.0, "partner":"2odr" }, - { - "sim":51.0, - "partner":"2fw3" - }, { "sim":51.0, "partner":"4ep9" @@ -376091,7 +377353,7 @@ }, { "sim":51.0, - "partner":"5lj7" + "partner":"2fw3" }, { "sim":51.0, @@ -376101,6 +377363,10 @@ "sim":51.0, "partner":"5lj6" }, + { + "sim":51.0, + "partner":"5lj7" + }, { "sim":51.0, "partner":"5uls" @@ -376215,11 +377481,11 @@ }, { "sim":50.0, - "partner":"4oxc" + "partner":"6gjw" }, { "sim":50.0, - "partner":"6gjw" + "partner":"4oxc" }, { "sim":50.0, @@ -376361,10 +377627,6 @@ "sim":50.0, "partner":"4a3z" }, - { - "sim":50.0, - "partner":"3sw1" - }, { "sim":50.0, "partner":"5j3w" @@ -376387,19 +377649,19 @@ }, { "sim":50.0, - "partner":"6ogx" + "partner":"3sw1" }, { "sim":50.0, - "partner":"6okm" + "partner":"6ogx" }, { "sim":50.0, - "partner":"6okn" + "partner":"6okm" }, { "sim":50.0, - "partner":"1vb6" + "partner":"6okn" }, { "sim":50.0, @@ -376421,6 +377683,10 @@ "sim":50.0, "partner":"3ffl" }, + { + "sim":50.0, + "partner":"1vb6" + }, { "sim":50.0, "partner":"2znz" @@ -376517,17 +377783,13 @@ "sim":50.0, "partner":"2i2w" }, - { - "sim":50.0, - "partner":"3kwe" - }, { "sim":50.0, "partner":"3kwd" }, { "sim":50.0, - "partner":"6nko" + "partner":"3kwe" }, { "sim":50.0, @@ -376539,12 +377801,16 @@ }, { "sim":50.0, - "partner":"3oci" + "partner":"6nko" }, { "sim":50.0, "partner":"3oc3" }, + { + "sim":50.0, + "partner":"3oci" + }, { "sim":50.0, "partner":"2fzl" @@ -376591,23 +377857,23 @@ }, { "sim":50.0, - "partner":"4njh" + "partner":"4njj" }, { "sim":50.0, - "partner":"4nji" + "partner":"4njk" }, { "sim":50.0, - "partner":"4njj" + "partner":"4njg" }, { "sim":50.0, - "partner":"4njk" + "partner":"4njh" }, { "sim":50.0, - "partner":"4njg" + "partner":"4nji" }, { "sim":50.0, @@ -376615,23 +377881,23 @@ }, { "sim":50.0, - "partner":"8vip" + "partner":"8vit" }, { "sim":50.0, - "partner":"8viq" + "partner":"3c6a" }, { "sim":50.0, - "partner":"8vir" + "partner":"8vip" }, { "sim":50.0, - "partner":"8vit" + "partner":"8viq" }, { "sim":50.0, - "partner":"3c6a" + "partner":"8vir" }, { "sim":50.0, @@ -376651,15 +377917,15 @@ }, { "sim":50.0, - "partner":"5cvd" + "partner":"5cve" }, { "sim":50.0, - "partner":"5cve" + "partner":"3qc1" }, { "sim":50.0, - "partner":"3qc1" + "partner":"5cvd" }, { "sim":50.0, @@ -376803,15 +378069,15 @@ }, { "sim":50.0, - "partner":"2ovb" + "partner":"2ovf" }, { "sim":50.0, - "partner":"2ovf" + "partner":"2ov8" }, { "sim":50.0, - "partner":"2ov8" + "partner":"2ovb" }, { "sim":50.0, @@ -376887,19 +378153,15 @@ }, { "sim":50.0, - "partner":"3rlg" - }, - { - "sim":50.0, - "partner":"4rw5" + "partner":"8r2x" }, { "sim":50.0, - "partner":"8r2x" + "partner":"3rlg" }, { "sim":50.0, - "partner":"4pgc" + "partner":"4rw5" }, { "sim":50.0, @@ -376919,7 +378181,7 @@ }, { "sim":50.0, - "partner":"3s3h" + "partner":"4pgc" }, { "sim":50.0, @@ -376933,6 +378195,10 @@ "sim":50.0, "partner":"3s3f" }, + { + "sim":50.0, + "partner":"3s3h" + }, { "sim":50.0, "partner":"4r7b" @@ -377015,11 +378281,11 @@ }, { "sim":50.0, - "partner":"5z75" + "partner":"3vxg" }, { "sim":50.0, - "partner":"3vxg" + "partner":"5z75" }, { "sim":50.0, @@ -377171,11 +378437,11 @@ }, { "sim":50.0, - "partner":"6put" + "partner":"6puw" }, { "sim":50.0, - "partner":"6puw" + "partner":"6puy" }, { "sim":50.0, @@ -377183,11 +378449,11 @@ }, { "sim":50.0, - "partner":"6puy" + "partner":"6v3k" }, { "sim":50.0, - "partner":"6v3k" + "partner":"6puz" }, { "sim":50.0, @@ -377195,19 +378461,19 @@ }, { "sim":50.0, - "partner":"6puz" + "partner":"6put" }, { "sim":50.0, - "partner":"2o0h" + "partner":"2o0j" }, { "sim":50.0, - "partner":"2o0j" + "partner":"2o0k" }, { "sim":50.0, - "partner":"2o0k" + "partner":"2o0h" }, { "sim":50.0, @@ -377305,10 +378571,6 @@ "sim":50.0, "partner":"4j2w" }, - { - "sim":50.0, - "partner":"4euh" - }, { "sim":50.0, "partner":"4eue" @@ -377319,11 +378581,11 @@ }, { "sim":50.0, - "partner":"3s8m" + "partner":"4euh" }, { "sim":50.0, - "partner":"5cu7" + "partner":"3s8m" }, { "sim":50.0, @@ -377337,6 +378599,10 @@ "sim":50.0, "partner":"5cx4" }, + { + "sim":50.0, + "partner":"5cu7" + }, { "sim":50.0, "partner":"5y0n" @@ -377443,15 +378709,15 @@ }, { "sim":50.0, - "partner":"2gps" + "partner":"2gpw" }, { "sim":50.0, - "partner":"6oi9" + "partner":"2gps" }, { "sim":50.0, - "partner":"2gpw" + "partner":"6oi9" }, { "sim":50.0, @@ -377575,15 +378841,15 @@ }, { "sim":50.0, - "partner":"4dqw" + "partner":"6gjv" }, { "sim":50.0, - "partner":"6gjv" + "partner":"6gk9" }, { "sim":50.0, - "partner":"6gk9" + "partner":"4dqw" }, { "sim":50.0, @@ -377699,15 +378965,15 @@ }, { "sim":50.0, - "partner":"5tsh" + "partner":"6olj" }, { "sim":50.0, - "partner":"6olj" + "partner":"5tsg" }, { "sim":50.0, - "partner":"5tsg" + "partner":"5tsh" }, { "sim":50.0, @@ -377876,12 +379142,12 @@ ], "subtitle":"The crystal structure of the eight-bladed symmetrical designer protein tako8 in the presence of tellurotungstic anderson-evans (tew)", "tags":[ - "designer protein", + "pom", "de novo protein", + "polyoxometalate", "packing", - "pom", "tew", - "polyoxometalate" + "designer protein" ], "keywords":[ "description", @@ -377918,15 +379184,15 @@ "seq_thr_sim_designed":[ { "sim":649.0, - "partner":"6g6n" + "partner":"6g6m" }, { "sim":649.0, - "partner":"6y7p" + "partner":"6g6n" }, { "sim":649.0, - "partner":"6g6m" + "partner":"6y7p" }, { "sim":646.0, @@ -377994,10 +379260,6 @@ "sim":243.0, "partner":"6wnx" }, - { - "sim":243.0, - "partner":"6m90" - }, { "sim":243.0, "partner":"6m91" @@ -378014,6 +379276,10 @@ "sim":243.0, "partner":"6m94" }, + { + "sim":243.0, + "partner":"6m90" + }, { "sim":243.0, "partner":"1p22" @@ -378056,51 +379322,47 @@ }, { "sim":203.0, - "partner":"6u8l" - }, - { - "sim":203.0, - "partner":"6u5m" + "partner":"6uj4" }, { "sim":203.0, - "partner":"6uhy" + "partner":"6uif" }, { "sim":203.0, - "partner":"6uoz" + "partner":"6u5y" }, { "sim":203.0, - "partner":"6uhz" + "partner":"6uik" }, { "sim":203.0, - "partner":"6uj4" + "partner":"6u8o" }, { "sim":203.0, - "partner":"6uif" + "partner":"6dy7" }, { "sim":203.0, - "partner":"6u5y" + "partner":"6u8l" }, { "sim":203.0, - "partner":"6uik" + "partner":"6u5m" }, { "sim":203.0, - "partner":"6u8o" + "partner":"6uhy" }, { "sim":203.0, - "partner":"6dy7" + "partner":"6uoz" }, { "sim":203.0, - "partner":"6pgf" + "partner":"6uhz" }, { "sim":203.0, @@ -378140,23 +379402,19 @@ }, { "sim":203.0, - "partner":"6iam" - }, - { - "sim":203.0, - "partner":"6byn" + "partner":"6pgf" }, { "sim":203.0, - "partner":"2g99" + "partner":"6iam" }, { "sim":203.0, - "partner":"5vfc" + "partner":"6byn" }, { "sim":203.0, - "partner":"6u6w" + "partner":"2g99" }, { "sim":203.0, @@ -378172,11 +379430,11 @@ }, { "sim":203.0, - "partner":"2h6k" + "partner":"6u6w" }, { "sim":203.0, - "partner":"5eap" + "partner":"5vfc" }, { "sim":203.0, @@ -378256,31 +379514,27 @@ }, { "sim":203.0, - "partner":"2h9n" - }, - { - "sim":203.0, - "partner":"6ofz" + "partner":"2h6k" }, { "sim":203.0, - "partner":"6ujj" + "partner":"5eap" }, { "sim":203.0, - "partner":"6e1y" + "partner":"6dai" }, { "sim":203.0, - "partner":"6ujl" + "partner":"6e1z" }, { "sim":203.0, - "partner":"6e1z" + "partner":"6pwv" }, { "sim":203.0, - "partner":"6dai" + "partner":"6dak" }, { "sim":203.0, @@ -378288,23 +379542,23 @@ }, { "sim":203.0, - "partner":"6pwv" + "partner":"6e22" }, { "sim":203.0, - "partner":"6dak" + "partner":"6e23" }, { "sim":203.0, - "partner":"6e22" + "partner":"6oi0" }, { "sim":203.0, - "partner":"6e23" + "partner":"6oi1" }, { "sim":203.0, - "partner":"6oi0" + "partner":"6oi2" }, { "sim":203.0, @@ -378312,7 +379566,7 @@ }, { "sim":203.0, - "partner":"6oi1" + "partner":"6oi3" }, { "sim":203.0, @@ -378324,15 +379578,15 @@ }, { "sim":203.0, - "partner":"6oi2" + "partner":"6ujh" }, { "sim":203.0, - "partner":"6oi3" + "partner":"6pww" }, { "sim":203.0, - "partner":"6ujh" + "partner":"6dar" }, { "sim":203.0, @@ -378340,31 +379594,43 @@ }, { "sim":203.0, - "partner":"6pww" + "partner":"6das" }, { "sim":203.0, - "partner":"6dar" + "partner":"6ucs" }, { "sim":203.0, - "partner":"6das" + "partner":"2o9k" }, { "sim":203.0, - "partner":"2o9k" + "partner":"6d9x" }, { "sim":203.0, - "partner":"6ucs" + "partner":"2h9m" }, { "sim":203.0, - "partner":"6d9x" + "partner":"6ofz" }, { "sim":203.0, - "partner":"2h9m" + "partner":"6ujj" + }, + { + "sim":203.0, + "partner":"2h9n" + }, + { + "sim":203.0, + "partner":"6e1y" + }, + { + "sim":203.0, + "partner":"6ujl" }, { "sim":203.0, @@ -378442,10 +379708,6 @@ "sim":203.0, "partner":"3uvo" }, - { - "sim":203.0, - "partner":"2xl3" - }, { "sim":203.0, "partner":"6kiw" @@ -378470,6 +379732,10 @@ "sim":203.0, "partner":"6kix" }, + { + "sim":203.0, + "partner":"2xl3" + }, { "sim":203.0, "partner":"2gnq" @@ -378498,6 +379764,10 @@ "sim":191.0, "partner":"5yzv" }, + { + "sim":188.0, + "partner":"8rl2" + }, { "sim":182.0, "partner":"3v7d" @@ -378510,10 +379780,6 @@ "sim":182.0, "partner":"1nex" }, - { - "sim":168.0, - "partner":"7btb" - }, { "sim":168.0, "partner":"4v7f" @@ -378524,35 +379790,39 @@ }, { "sim":168.0, - "partner":"3jct" + "partner":"7bt6" }, { "sim":168.0, - "partner":"5jcs" + "partner":"6ft6" }, { "sim":168.0, - "partner":"7bt6" + "partner":"6ylh" }, { "sim":168.0, - "partner":"6ft6" + "partner":"3jct" }, { "sim":168.0, - "partner":"6ylh" + "partner":"5jcs" }, { "sim":168.0, "partner":"6m62" }, + { + "sim":168.0, + "partner":"6ylg" + }, { "sim":168.0, "partner":"4wju" }, { "sim":168.0, - "partner":"6ylg" + "partner":"7btb" }, { "sim":167.0, @@ -378580,11 +379850,11 @@ }, { "sim":151.0, - "partner":"6ah0" + "partner":"6ff7" }, { "sim":151.0, - "partner":"6ff7" + "partner":"6ah0" }, { "sim":151.0, @@ -378592,15 +379862,15 @@ }, { "sim":151.0, - "partner":"5xjc" + "partner":"6icz" }, { "sim":151.0, - "partner":"5z57" + "partner":"5xjc" }, { "sim":151.0, - "partner":"6icz" + "partner":"5z57" }, { "sim":151.0, @@ -378612,11 +379882,11 @@ }, { "sim":151.0, - "partner":"5z56" + "partner":"6qw6" }, { "sim":151.0, - "partner":"6qw6" + "partner":"5z56" }, { "sim":151.0, @@ -378624,15 +379894,15 @@ }, { "sim":151.0, - "partner":"5o9z" + "partner":"6qx9" }, { "sim":151.0, - "partner":"5yzg" + "partner":"5o9z" }, { "sim":151.0, - "partner":"6qx9" + "partner":"5yzg" }, { "sim":151.0, @@ -378656,15 +379926,7 @@ }, { "sim":149.0, - "partner":"5ukk" - }, - { - "sim":149.0, - "partner":"7k7z" - }, - { - "sim":149.0, - "partner":"7jjo" + "partner":"8wgb" }, { "sim":149.0, @@ -378690,17 +379952,13 @@ "sim":149.0, "partner":"7k7l" }, - { - "sim":149.0, - "partner":"5he2" - }, { "sim":149.0, "partner":"6g79" }, { "sim":149.0, - "partner":"8wgb" + "partner":"5he2" }, { "sim":149.0, @@ -378708,27 +379966,27 @@ }, { "sim":149.0, - "partner":"6wi9" + "partner":"5ukk" }, { "sim":149.0, - "partner":"4kfm" + "partner":"7k7z" }, { "sim":149.0, - "partner":"6x18" + "partner":"7jjo" }, { "sim":149.0, - "partner":"5kdo" + "partner":"7dhr" }, { "sim":149.0, - "partner":"7dhr" + "partner":"8k4s" }, { "sim":149.0, - "partner":"3v5w" + "partner":"5kdo" }, { "sim":149.0, @@ -378742,37 +380000,49 @@ "sim":149.0, "partner":"6x19" }, + { + "sim":149.0, + "partner":"3v5w" + }, + { + "sim":149.0, + "partner":"8p15" + }, { "sim":149.0, "partner":"6niy" }, + { + "sim":149.0, + "partner":"8vve" + }, { "sim":149.0, "partner":"6x1a" }, { "sim":149.0, - "partner":"8k4s" + "partner":"8vvf" }, { "sim":149.0, - "partner":"1gg2" + "partner":"6c2y" }, { "sim":149.0, - "partner":"3pvu" + "partner":"6kpf" }, { "sim":149.0, - "partner":"4pnk" + "partner":"8zjg" }, { "sim":149.0, - "partner":"6c2y" + "partner":"3pvu" }, { "sim":149.0, - "partner":"8p12" + "partner":"4pnk" }, { "sim":149.0, @@ -378784,7 +380054,7 @@ }, { "sim":149.0, - "partner":"6kpf" + "partner":"7dhi" }, { "sim":149.0, @@ -378792,24 +380062,28 @@ }, { "sim":149.0, - "partner":"1gp2" + "partner":"6whc" }, { "sim":149.0, - "partner":"5wg3" + "partner":"8vvg" }, { "sim":149.0, - "partner":"6whc" + "partner":"1gg2" }, { "sim":149.0, - "partner":"7dhi" + "partner":"5wg3" }, { "sim":149.0, "partner":"3psc" }, + { + "sim":149.0, + "partner":"6wzg" + }, { "sim":149.0, "partner":"1omw" @@ -378820,7 +380094,7 @@ }, { "sim":149.0, - "partner":"8p13" + "partner":"1gp2" }, { "sim":149.0, @@ -378832,15 +380106,27 @@ }, { "sim":149.0, - "partner":"6wzg" + "partner":"1xhm" }, { "sim":149.0, - "partner":"1xhm" + "partner":"3pvw" }, { "sim":149.0, - "partner":"3pvw" + "partner":"6qno" + }, + { + "sim":149.0, + "partner":"6rmv" + }, + { + "sim":149.0, + "partner":"8p12" + }, + { + "sim":149.0, + "partner":"8xqe" }, { "sim":149.0, @@ -378852,11 +380138,11 @@ }, { "sim":149.0, - "partner":"6qno" + "partner":"6li3" }, { "sim":149.0, - "partner":"6rmv" + "partner":"8z7j" }, { "sim":149.0, @@ -378864,19 +380150,27 @@ }, { "sim":149.0, - "partner":"6li3" + "partner":"6u7c" }, { "sim":149.0, - "partner":"8p15" + "partner":"6wi9" }, { "sim":149.0, - "partner":"6u7c" + "partner":"6x18" }, { "sim":149.0, - "partner":"6m1h" + "partner":"8p13" + }, + { + "sim":149.0, + "partner":"8xqf" + }, + { + "sim":149.0, + "partner":"4kfm" }, { "sim":149.0, @@ -378884,11 +380178,11 @@ }, { "sim":149.0, - "partner":"5tdh" + "partner":"6m1h" }, { "sim":149.0, - "partner":"6xbk" + "partner":"5tdh" }, { "sim":149.0, @@ -378924,11 +380218,7 @@ }, { "sim":149.0, - "partner":"6nbi" - }, - { - "sim":149.0, - "partner":"6oij" + "partner":"6xbk" }, { "sim":149.0, @@ -378966,6 +380256,14 @@ "sim":149.0, "partner":"6crk" }, + { + "sim":149.0, + "partner":"6nbi" + }, + { + "sim":149.0, + "partner":"6oij" + }, { "sim":149.0, "partner":"6lfm" @@ -378984,59 +380282,59 @@ }, { "sim":149.0, - "partner":"6d9h" + "partner":"6vcb" }, { "sim":149.0, - "partner":"6p9x" + "partner":"6p9y" }, { "sim":149.0, - "partner":"6uva" + "partner":"8xx3" }, { "sim":149.0, - "partner":"6k42" + "partner":"5ukm" }, { "sim":149.0, - "partner":"6xox" + "partner":"6e3y" }, { "sim":149.0, - "partner":"6vcb" + "partner":"6m8s" }, { "sim":149.0, - "partner":"5ukm" + "partner":"6ni3" }, { "sim":149.0, - "partner":"6p9y" + "partner":"7c2e" }, { "sim":149.0, - "partner":"6e3y" + "partner":"8xx7" }, { "sim":149.0, - "partner":"6m8s" + "partner":"8xwv" }, { "sim":149.0, - "partner":"6ni3" + "partner":"8xxh" }, { "sim":149.0, - "partner":"7c2e" + "partner":"6b3j" }, { "sim":149.0, - "partner":"6b3j" + "partner":"6orv" }, { "sim":149.0, - "partner":"6orv" + "partner":"8tyw" }, { "sim":149.0, @@ -379044,12 +380342,44 @@ }, { "sim":149.0, - "partner":"8tyw" + "partner":"8jzp" + }, + { + "sim":149.0, + "partner":"8xxx" }, { "sim":149.0, "partner":"6uun" }, + { + "sim":149.0, + "partner":"8xxr" + }, + { + "sim":149.0, + "partner":"6d9h" + }, + { + "sim":149.0, + "partner":"6p9x" + }, + { + "sim":149.0, + "partner":"6uva" + }, + { + "sim":149.0, + "partner":"8xx6" + }, + { + "sim":149.0, + "partner":"6k42" + }, + { + "sim":149.0, + "partner":"6xox" + }, { "sim":149.0, "partner":"5vai" @@ -379120,12 +380450,24 @@ }, { "sim":149.0, - "partner":"7d68" + "partner":"8zfz" }, { "sim":149.0, "partner":"8vhf" }, + { + "sim":149.0, + "partner":"7d68" + }, + { + "sim":149.0, + "partner":"8wwi" + }, + { + "sim":149.0, + "partner":"8wwj" + }, { "sim":149.0, "partner":"8wwk" @@ -379148,15 +380490,11 @@ }, { "sim":149.0, - "partner":"8wwi" - }, - { - "sim":149.0, - "partner":"8wwj" + "partner":"6vn7" }, { "sim":149.0, - "partner":"6vn7" + "partner":"8jsr" }, { "sim":149.0, @@ -379196,11 +380534,11 @@ }, { "sim":147.0, - "partner":"1got" + "partner":"2trc" }, { "sim":147.0, - "partner":"2trc" + "partner":"1got" }, { "sim":147.0, @@ -379240,11 +380578,11 @@ }, { "sim":147.0, - "partner":"6t9k" + "partner":"6t9i" }, { "sim":147.0, - "partner":"6t9i" + "partner":"6t9k" }, { "sim":145.0, @@ -379256,11 +380594,11 @@ }, { "sim":145.0, - "partner":"5wsg" + "partner":"6j6q" }, { "sim":145.0, - "partner":"6j6q" + "partner":"5wsg" }, { "sim":145.0, @@ -379274,6 +380612,10 @@ "sim":145.0, "partner":"5y88" }, + { + "sim":145.0, + "partner":"6j6g" + }, { "sim":145.0, "partner":"5gm6" @@ -379284,7 +380626,7 @@ }, { "sim":145.0, - "partner":"6j6g" + "partner":"6j6n" }, { "sim":145.0, @@ -379292,11 +380634,11 @@ }, { "sim":145.0, - "partner":"6j6n" + "partner":"5lqw" }, { "sim":145.0, - "partner":"5lqw" + "partner":"6j6h" }, { "sim":145.0, @@ -379306,10 +380648,6 @@ "sim":145.0, "partner":"5ylz" }, - { - "sim":145.0, - "partner":"6j6h" - }, { "sim":142.0, "partner":"5afu" @@ -379568,23 +380906,23 @@ }, { "sim":123.0, - "partner":"5oql" + "partner":"6rxz" }, { "sim":123.0, - "partner":"6rxz" + "partner":"5oql" }, { "sim":122.0, - "partner":"6i7o" + "partner":"4v7h" }, { "sim":122.0, - "partner":"4v7h" + "partner":"6zvi" }, { "sim":122.0, - "partner":"6zvi" + "partner":"6i7o" }, { "sim":122.0, @@ -379610,22 +380948,6 @@ "sim":121.0, "partner":"6wdr" }, - { - "sim":121.0, - "partner":"4u4q" - }, - { - "sim":121.0, - "partner":"5obm" - }, - { - "sim":121.0, - "partner":"4u4r" - }, - { - "sim":121.0, - "partner":"5tgm" - }, { "sim":121.0, "partner":"4u6f" @@ -379640,27 +380962,27 @@ }, { "sim":121.0, - "partner":"6woo" + "partner":"4uer" }, { "sim":121.0, - "partner":"4uer" + "partner":"6gqv" }, { "sim":121.0, - "partner":"4u4u" + "partner":"6q8y" }, { "sim":121.0, - "partner":"5mei" + "partner":"4u4u" }, { "sim":121.0, - "partner":"6gqv" + "partner":"5mei" }, { "sim":121.0, - "partner":"6q8y" + "partner":"5tgm" }, { "sim":121.0, @@ -379682,6 +381004,10 @@ "sim":121.0, "partner":"5ndv" }, + { + "sim":121.0, + "partner":"6gq1" + }, { "sim":121.0, "partner":"5ndw" @@ -379696,7 +381022,7 @@ }, { "sim":121.0, - "partner":"6gq1" + "partner":"6gqb" }, { "sim":121.0, @@ -379710,10 +381036,6 @@ "sim":121.0, "partner":"5dgv" }, - { - "sim":121.0, - "partner":"6gqb" - }, { "sim":121.0, "partner":"4u50" @@ -379724,15 +381046,15 @@ }, { "sim":121.0, - "partner":"5tbw" + "partner":"6s47" }, { "sim":121.0, - "partner":"4u51" + "partner":"5tbw" }, { "sim":121.0, - "partner":"6s47" + "partner":"4u51" }, { "sim":121.0, @@ -379784,23 +381106,19 @@ }, { "sim":121.0, - "partner":"3j6y" - }, - { - "sim":121.0, - "partner":"4v8y" + "partner":"4u4q" }, { "sim":121.0, - "partner":"6zu9" + "partner":"5obm" }, { "sim":121.0, - "partner":"5juo" + "partner":"4u4r" }, { "sim":121.0, - "partner":"8t3f" + "partner":"6woo" }, { "sim":121.0, @@ -379812,11 +381130,11 @@ }, { "sim":121.0, - "partner":"5mc6" + "partner":"8t3f" }, { "sim":121.0, - "partner":"5jus" + "partner":"5mc6" }, { "sim":121.0, @@ -379824,47 +381142,47 @@ }, { "sim":121.0, - "partner":"8p4v" + "partner":"5jus" }, { "sim":121.0, - "partner":"8t2y" + "partner":"6t7i" }, { "sim":121.0, - "partner":"6t7i" + "partner":"6rbe" }, { "sim":121.0, - "partner":"8t3a" + "partner":"6t83" }, { "sim":121.0, - "partner":"6rbe" + "partner":"3j78" }, { "sim":121.0, - "partner":"6t83" + "partner":"8t2y" }, { "sim":121.0, - "partner":"8t30" + "partner":"3rfg" }, { "sim":121.0, - "partner":"3j78" + "partner":"5juu" }, { "sim":121.0, - "partner":"3rfg" + "partner":"6snt" }, { "sim":121.0, - "partner":"5juu" + "partner":"8t3a" }, { "sim":121.0, - "partner":"8t3c" + "partner":"8t30" }, { "sim":121.0, @@ -379876,15 +381194,19 @@ }, { "sim":121.0, - "partner":"6snt" + "partner":"8t3c" }, { "sim":121.0, - "partner":"8t3e" + "partner":"4v88" }, { "sim":121.0, - "partner":"4v88" + "partner":"6xir" + }, + { + "sim":121.0, + "partner":"8p4v" }, { "sim":121.0, @@ -379892,19 +381214,23 @@ }, { "sim":121.0, - "partner":"4v6i" + "partner":"6hhq" }, { "sim":121.0, - "partner":"5jup" + "partner":"8t3e" }, { "sim":121.0, - "partner":"6xir" + "partner":"4v6i" }, { "sim":121.0, - "partner":"6hhq" + "partner":"5jup" + }, + { + "sim":121.0, + "partner":"6sv4" }, { "sim":121.0, @@ -379912,7 +381238,7 @@ }, { "sim":121.0, - "partner":"8p9a" + "partner":"6z6k" }, { "sim":121.0, @@ -379920,7 +381246,7 @@ }, { "sim":121.0, - "partner":"6sv4" + "partner":"3j77" }, { "sim":121.0, @@ -379928,15 +381254,15 @@ }, { "sim":121.0, - "partner":"6z6k" + "partner":"5jut" }, { "sim":121.0, - "partner":"3j77" + "partner":"6fai" }, { "sim":121.0, - "partner":"5jut" + "partner":"6zu9" }, { "sim":121.0, @@ -379944,31 +381270,35 @@ }, { "sim":121.0, - "partner":"6fai" + "partner":"8p9a" }, { "sim":121.0, - "partner":"8t3b" + "partner":"3j6y" }, { "sim":121.0, - "partner":"8t3d" + "partner":"4v8y" }, { "sim":121.0, - "partner":"4j0w" + "partner":"8t3b" }, { "sim":121.0, - "partner":"6nd4" + "partner":"5juo" }, { "sim":121.0, - "partner":"6ke6" + "partner":"8t3d" }, { "sim":121.0, - "partner":"6lqq" + "partner":"4j0w" + }, + { + "sim":121.0, + "partner":"6nd4" }, { "sim":121.0, @@ -380020,19 +381350,23 @@ }, { "sim":121.0, - "partner":"5wlc" + "partner":"6lqt" }, { "sim":121.0, - "partner":"6lqt" + "partner":"5wlc" }, { "sim":121.0, "partner":"6lqp" }, { - "sim":120.0, - "partner":"7a1g" + "sim":121.0, + "partner":"6ke6" + }, + { + "sim":121.0, + "partner":"6lqq" }, { "sim":120.0, @@ -380044,11 +381378,11 @@ }, { "sim":120.0, - "partner":"6t7t" + "partner":"8uti" }, { "sim":120.0, - "partner":"8ut0" + "partner":"6t7t" }, { "sim":120.0, @@ -380056,7 +381390,11 @@ }, { "sim":120.0, - "partner":"8uti" + "partner":"8ut0" + }, + { + "sim":120.0, + "partner":"7a1g" }, { "sim":120.0, @@ -380138,10 +381476,6 @@ "sim":113.0, "partner":"5cvo" }, - { - "sim":112.0, - "partner":"6olz" - }, { "sim":112.0, "partner":"6gz4" @@ -380164,7 +381498,7 @@ }, { "sim":112.0, - "partner":"6zol" + "partner":"6olz" }, { "sim":112.0, @@ -380180,15 +381514,15 @@ }, { "sim":112.0, - "partner":"4aow" + "partner":"6zol" }, { - "sim":111.0, - "partner":"6zvj" + "sim":112.0, + "partner":"4aow" }, { "sim":111.0, - "partner":"6ole" + "partner":"6zvj" }, { "sim":111.0, @@ -380208,28 +381542,12 @@ }, { "sim":111.0, - "partner":"6yam" - }, - { - "sim":111.0, - "partner":"6fec" - }, - { - "sim":111.0, - "partner":"6mtb" - }, - { - "sim":111.0, - "partner":"6zvh" + "partner":"6ole" }, { "sim":111.0, "partner":"3jaj" }, - { - "sim":111.0, - "partner":"8ukb" - }, { "sim":111.0, "partner":"6r6g" @@ -380240,11 +381558,11 @@ }, { "sim":111.0, - "partner":"3jai" + "partner":"6r6p" }, { "sim":111.0, - "partner":"6r6p" + "partner":"3jai" }, { "sim":111.0, @@ -380260,12 +381578,16 @@ }, { "sim":111.0, - "partner":"3jah" + "partner":"8ukb" }, { "sim":111.0, "partner":"6mtc" }, + { + "sim":111.0, + "partner":"3jah" + }, { "sim":111.0, "partner":"6r5q" @@ -380292,87 +381614,87 @@ }, { "sim":111.0, - "partner":"3jan" + "partner":"6yam" }, { "sim":111.0, - "partner":"5lzv" + "partner":"3jan" }, { "sim":111.0, - "partner":"6zmw" + "partner":"6fec" }, { "sim":111.0, - "partner":"7jqc" + "partner":"6mtb" }, { "sim":111.0, - "partner":"4kzx" + "partner":"6zvh" }, { "sim":111.0, - "partner":"6ip6" + "partner":"4ujd" }, { "sim":111.0, - "partner":"6p5n" + "partner":"4uje" }, { "sim":111.0, - "partner":"6w2t" + "partner":"6p5j" }, { "sim":111.0, - "partner":"6zxg" + "partner":"4kzy" }, { "sim":111.0, - "partner":"6zmi" + "partner":"4ug0" }, { "sim":111.0, - "partner":"4ujd" + "partner":"5lzy" }, { "sim":111.0, - "partner":"4uje" + "partner":"6zxh" }, { "sim":111.0, - "partner":"7a09" + "partner":"3j7p" }, { "sim":111.0, - "partner":"7k5i" + "partner":"6hcf" }, { "sim":111.0, - "partner":"4kzy" + "partner":"6z6l" }, { "sim":111.0, - "partner":"4ug0" + "partner":"6zmo" }, { "sim":111.0, - "partner":"5lzy" + "partner":"6p5k" }, { "sim":111.0, - "partner":"3j7p" + "partner":"6zm7" }, { "sim":111.0, - "partner":"6p5j" + "partner":"6zme" }, { "sim":111.0, - "partner":"6zxh" + "partner":"6zon" }, { "sim":111.0, - "partner":"6hcf" + "partner":"6zp4" }, { "sim":111.0, @@ -380384,63 +381706,75 @@ }, { "sim":111.0, - "partner":"6z6l" + "partner":"5vyc" }, { "sim":111.0, - "partner":"6zmo" + "partner":"6hcm" }, { "sim":111.0, - "partner":"5vyc" + "partner":"6sgc" }, { "sim":111.0, - "partner":"6p5k" + "partner":"6y2l" }, { "sim":111.0, - "partner":"6zm7" + "partner":"5lzu" }, { "sim":111.0, - "partner":"6zme" + "partner":"6ip5" }, { "sim":111.0, - "partner":"6zon" + "partner":"5lks" }, { "sim":111.0, - "partner":"6zp4" + "partner":"6g18" }, { "sim":111.0, - "partner":"5lzu" + "partner":"6z6n" }, { "sim":111.0, - "partner":"6hcm" + "partner":"6zlw" }, { "sim":111.0, - "partner":"6sgc" + "partner":"5lzx" }, { "sim":111.0, - "partner":"6y2l" + "partner":"6g51" }, { "sim":111.0, - "partner":"5lks" + "partner":"6zmt" }, { "sim":111.0, - "partner":"5lzx" + "partner":"6hcq" }, { "sim":111.0, - "partner":"6ip5" + "partner":"4ujc" + }, + { + "sim":111.0, + "partner":"4v6x" + }, + { + "sim":111.0, + "partner":"6zxd" + }, + { + "sim":111.0, + "partner":"6p5i" }, { "sim":111.0, @@ -380448,160 +381782,164 @@ }, { "sim":111.0, - "partner":"6g18" + "partner":"5flx" }, { "sim":111.0, - "partner":"6z6n" + "partner":"6d90" }, { "sim":111.0, - "partner":"6zlw" + "partner":"6hcj" }, { "sim":111.0, - "partner":"4ujc" + "partner":"6ip8" }, { "sim":111.0, - "partner":"4v6x" + "partner":"5lzt" }, { "sim":111.0, - "partner":"6g51" + "partner":"6d9j" }, { "sim":111.0, - "partner":"6zmt" + "partner":"6p4g" }, { "sim":111.0, - "partner":"6hcq" + "partner":"6w2s" }, { "sim":111.0, - "partner":"5flx" + "partner":"4d61" }, { "sim":111.0, - "partner":"6zxd" + "partner":"6g5h" }, { "sim":111.0, - "partner":"5lzt" + "partner":"6zxe" }, { "sim":111.0, - "partner":"6p5i" + "partner":"5lzw" }, { "sim":111.0, - "partner":"6d90" + "partner":"5t2c" }, { "sim":111.0, - "partner":"6hcj" + "partner":"6g5i" }, { "sim":111.0, - "partner":"6ip8" + "partner":"6y57" }, { "sim":111.0, - "partner":"4d61" + "partner":"5aj0" }, { "sim":111.0, - "partner":"5lzw" + "partner":"6ybs" }, { "sim":111.0, - "partner":"5t2c" + "partner":"6z6m" }, { "sim":111.0, - "partner":"6d9j" + "partner":"6zxf" }, { "sim":111.0, - "partner":"6p4g" + "partner":"4d5l" }, { "sim":111.0, - "partner":"6w2s" + "partner":"6p4h" }, { "sim":111.0, - "partner":"6g5h" + "partner":"5lzz" }, { "sim":111.0, - "partner":"6zxe" + "partner":"6g53" }, { "sim":111.0, - "partner":"5aj0" + "partner":"6y0g" }, { "sim":111.0, - "partner":"6g5i" + "partner":"7jqb" }, { "sim":111.0, - "partner":"4d5l" + "partner":"4v5z" }, { "sim":111.0, - "partner":"6y57" + "partner":"5lzs" }, { "sim":111.0, - "partner":"5lzz" + "partner":"6zmw" }, { "sim":111.0, - "partner":"6ybs" + "partner":"6ip6" }, { "sim":111.0, - "partner":"6z6m" + "partner":"6p5n" }, { "sim":111.0, - "partner":"6zxf" + "partner":"6w2t" }, { "sim":111.0, - "partner":"6p4h" + "partner":"6zxg" }, { "sim":111.0, - "partner":"4v5z" + "partner":"7jqc" }, { "sim":111.0, - "partner":"5lzs" + "partner":"5lzv" }, { "sim":111.0, - "partner":"6g53" + "partner":"6zmi" }, { "sim":111.0, - "partner":"6y0g" + "partner":"4kzx" }, { "sim":111.0, - "partner":"7jqb" + "partner":"7a09" }, { "sim":111.0, - "partner":"5vh9" + "partner":"7k5i" }, { "sim":111.0, "partner":"5vlj" }, + { + "sim":111.0, + "partner":"5vh9" + }, { "sim":111.0, "partner":"5wve" @@ -380628,11 +381966,11 @@ }, { "sim":106.0, - "partner":"6uh5" + "partner":"6ugm" }, { "sim":106.0, - "partner":"6ugm" + "partner":"6uh5" }, { "sim":105.0, @@ -380700,35 +382038,35 @@ }, { "sim":94.0, - "partner":"3jam" + "partner":"6fyx" }, { "sim":94.0, - "partner":"3jap" + "partner":"6uz7" }, { "sim":94.0, - "partner":"6fyy" + "partner":"3j80" }, { "sim":94.0, - "partner":"3j80" + "partner":"3j81" }, { "sim":94.0, - "partner":"6fyx" + "partner":"8s8k" }, { "sim":94.0, - "partner":"6uz7" + "partner":"3jam" }, { "sim":94.0, - "partner":"3j81" + "partner":"3jap" }, { "sim":94.0, - "partner":"8s8k" + "partner":"6fyy" }, { "sim":94.0, @@ -380756,35 +382094,35 @@ }, { "sim":93.0, - "partner":"6qtv" + "partner":"6qto" }, { "sim":93.0, - "partner":"6qtw" + "partner":"6qtq" }, { "sim":93.0, - "partner":"6qtx" + "partner":"6qtr" }, { "sim":93.0, - "partner":"6qto" + "partner":"6qtt" }, { "sim":93.0, - "partner":"6qtq" + "partner":"6qtu" }, { "sim":93.0, - "partner":"6qtr" + "partner":"6qtv" }, { "sim":93.0, - "partner":"6qtt" + "partner":"6qtw" }, { "sim":93.0, - "partner":"6qtu" + "partner":"6qtx" }, { "sim":93.0, @@ -380796,23 +382134,23 @@ }, { "sim":93.0, - "partner":"2xu7" + "partner":"6g16" }, { "sim":93.0, - "partner":"6g16" + "partner":"7aoa" }, { "sim":93.0, - "partner":"5fxy" + "partner":"8vml" }, { "sim":93.0, - "partner":"7aoa" + "partner":"6c24" }, { "sim":93.0, - "partner":"6c24" + "partner":"5fxy" }, { "sim":93.0, @@ -380822,10 +382160,18 @@ "sim":93.0, "partner":"4pby" }, + { + "sim":93.0, + "partner":"8vmi" + }, { "sim":93.0, "partner":"4pbz" }, + { + "sim":93.0, + "partner":"8vnv" + }, { "sim":93.0, "partner":"4pc0" @@ -380834,13 +382180,21 @@ "sim":93.0, "partner":"6c23" }, + { + "sim":93.0, + "partner":"6zrd" + }, + { + "sim":93.0, + "partner":"8vnz" + }, { "sim":93.0, "partner":"3gfc" }, { "sim":93.0, - "partner":"6zrd" + "partner":"2xu7" }, { "sim":93.0, @@ -380860,15 +382214,15 @@ }, { "sim":93.0, - "partner":"6nq3" + "partner":"5wai" }, { "sim":93.0, - "partner":"5wai" + "partner":"5wak" }, { "sim":93.0, - "partner":"5wak" + "partner":"6nq3" }, { "sim":93.0, @@ -380880,11 +382234,11 @@ }, { "sim":93.0, - "partner":"5xxq" + "partner":"5y1u" }, { "sim":93.0, - "partner":"5y1u" + "partner":"5xxq" }, { "sim":92.0, @@ -380910,21 +382264,13 @@ "sim":91.0, "partner":"6tc0" }, - { - "sim":90.0, - "partner":"4v5o" - }, { "sim":90.0, "partner":"4bts" }, { - "sim":89.0, - "partner":"5flc" - }, - { - "sim":89.0, - "partner":"6sb0" + "sim":90.0, + "partner":"4v5o" }, { "sim":89.0, @@ -380964,11 +382310,11 @@ }, { "sim":89.0, - "partner":"4jt6" + "partner":"6zwo" }, { "sim":89.0, - "partner":"6zwo" + "partner":"4jt6" }, { "sim":89.0, @@ -380980,12 +382326,20 @@ }, { "sim":89.0, - "partner":"5wbu" + "partner":"6sb0" + }, + { + "sim":89.0, + "partner":"5flc" }, { "sim":89.0, "partner":"5wby" }, + { + "sim":89.0, + "partner":"5wbu" + }, { "sim":89.0, "partner":"5igq" @@ -381100,11 +382454,11 @@ }, { "sim":75.0, - "partner":"2aq5" + "partner":"2b4e" }, { "sim":75.0, - "partner":"2b4e" + "partner":"2aq5" }, { "sim":74.0, @@ -381112,11 +382466,11 @@ }, { "sim":74.0, - "partner":"1gxr" + "partner":"2ce8" }, { "sim":74.0, - "partner":"2ce8" + "partner":"1gxr" }, { "sim":74.0, @@ -381140,11 +382494,11 @@ }, { "sim":73.0, - "partner":"5m2n" + "partner":"6qk7" }, { "sim":73.0, - "partner":"6qk7" + "partner":"5m2n" }, { "sim":73.0, @@ -381168,11 +382522,11 @@ }, { "sim":71.0, - "partner":"1pev" + "partner":"1nr0" }, { "sim":71.0, - "partner":"1nr0" + "partner":"1pev" }, { "sim":70.0, @@ -381226,14 +382580,6 @@ "sim":61.0, "partner":"3mmy" }, - { - "sim":60.0, - "partner":"5m5g" - }, - { - "sim":60.0, - "partner":"5wfd" - }, { "sim":60.0, "partner":"5bjs" @@ -381266,6 +382612,14 @@ "sim":60.0, "partner":"5wfc" }, + { + "sim":60.0, + "partner":"5m5g" + }, + { + "sim":60.0, + "partner":"5wfd" + }, { "sim":59.0, "partner":"6v0n" @@ -381296,47 +382650,47 @@ }, { "sim":59.0, - "partner":"4x63" + "partner":"4x60" }, { "sim":59.0, - "partner":"6uxx" + "partner":"4x61" }, { "sim":59.0, - "partner":"6uxy" + "partner":"5c9z" }, { "sim":59.0, - "partner":"4x60" + "partner":"5emj" }, { "sim":59.0, - "partner":"4x61" + "partner":"6k1s" }, { "sim":59.0, - "partner":"5c9z" + "partner":"5emk" }, { "sim":59.0, - "partner":"5emj" + "partner":"5eml" }, { "sim":59.0, - "partner":"5emk" + "partner":"5emm" }, { "sim":59.0, - "partner":"6k1s" + "partner":"6uxx" }, { "sim":59.0, - "partner":"5eml" + "partner":"4x63" }, { "sim":59.0, - "partner":"5emm" + "partner":"6uxy" }, { "sim":59.0, @@ -381390,7 +382744,7 @@ ], "seq_max_sim_designed":{ "sim":649.0, - "partner":"6g6n" + "partner":"6g6m" }, "seq_max_sim_natural":{ "sim":323.0, @@ -381456,13 +382810,13 @@ ], "subtitle":"The complex between the eight-bladed symmetrical designer protein tako8 and the silicotungstic acid keggin (sta)", "tags":[ - "framework", - "hybrid", - "designer protein", - "de novo protein", "pom", + "sta", + "de novo protein", "polyoxometalate", - "sta" + "hybrid", + "framework", + "designer protein" ], "keywords":[ "description", @@ -381499,19 +382853,19 @@ "seq_thr_sim_designed":[ { "sim":645.0, - "partner":"6g6n" + "partner":"6g6m" }, { "sim":645.0, - "partner":"6y7p" + "partner":"6y7n" }, { "sim":645.0, - "partner":"6y7n" + "partner":"6g6n" }, { "sim":645.0, - "partner":"6g6m" + "partner":"6y7p" }, { "sim":441.0, @@ -381575,10 +382929,6 @@ "sim":243.0, "partner":"6wnx" }, - { - "sim":243.0, - "partner":"6m90" - }, { "sim":243.0, "partner":"6m91" @@ -381595,6 +382945,10 @@ "sim":243.0, "partner":"6m94" }, + { + "sim":243.0, + "partner":"6m90" + }, { "sim":243.0, "partner":"1p22" @@ -381637,51 +382991,47 @@ }, { "sim":203.0, - "partner":"6u8l" - }, - { - "sim":203.0, - "partner":"6u5m" + "partner":"6uj4" }, { "sim":203.0, - "partner":"6uhy" + "partner":"6uif" }, { "sim":203.0, - "partner":"6uoz" + "partner":"6u5y" }, { "sim":203.0, - "partner":"6uhz" + "partner":"6uik" }, { "sim":203.0, - "partner":"6uj4" + "partner":"6u8o" }, { "sim":203.0, - "partner":"6uif" + "partner":"6dy7" }, { "sim":203.0, - "partner":"6u5y" + "partner":"6u8l" }, { "sim":203.0, - "partner":"6uik" + "partner":"6u5m" }, { "sim":203.0, - "partner":"6u8o" + "partner":"6uhy" }, { "sim":203.0, - "partner":"6dy7" + "partner":"6uoz" }, { "sim":203.0, - "partner":"6pgf" + "partner":"6uhz" }, { "sim":203.0, @@ -381721,23 +383071,19 @@ }, { "sim":203.0, - "partner":"6iam" - }, - { - "sim":203.0, - "partner":"6byn" + "partner":"6pgf" }, { "sim":203.0, - "partner":"2g99" + "partner":"6iam" }, { "sim":203.0, - "partner":"5vfc" + "partner":"6byn" }, { "sim":203.0, - "partner":"6u6w" + "partner":"2g99" }, { "sim":203.0, @@ -381753,11 +383099,11 @@ }, { "sim":203.0, - "partner":"2h6k" + "partner":"6u6w" }, { "sim":203.0, - "partner":"5eap" + "partner":"5vfc" }, { "sim":203.0, @@ -381837,31 +383183,27 @@ }, { "sim":203.0, - "partner":"2h9n" - }, - { - "sim":203.0, - "partner":"6ofz" + "partner":"2h6k" }, { "sim":203.0, - "partner":"6ujj" + "partner":"5eap" }, { "sim":203.0, - "partner":"6e1y" + "partner":"6dai" }, { "sim":203.0, - "partner":"6ujl" + "partner":"6e1z" }, { "sim":203.0, - "partner":"6e1z" + "partner":"6pwv" }, { "sim":203.0, - "partner":"6dai" + "partner":"6dak" }, { "sim":203.0, @@ -381869,23 +383211,23 @@ }, { "sim":203.0, - "partner":"6pwv" + "partner":"6e22" }, { "sim":203.0, - "partner":"6dak" + "partner":"6e23" }, { "sim":203.0, - "partner":"6e22" + "partner":"6oi0" }, { "sim":203.0, - "partner":"6e23" + "partner":"6oi1" }, { "sim":203.0, - "partner":"6oi0" + "partner":"6oi2" }, { "sim":203.0, @@ -381893,7 +383235,7 @@ }, { "sim":203.0, - "partner":"6oi1" + "partner":"6oi3" }, { "sim":203.0, @@ -381905,15 +383247,15 @@ }, { "sim":203.0, - "partner":"6oi2" + "partner":"6ujh" }, { "sim":203.0, - "partner":"6oi3" + "partner":"6pww" }, { "sim":203.0, - "partner":"6ujh" + "partner":"6dar" }, { "sim":203.0, @@ -381921,31 +383263,43 @@ }, { "sim":203.0, - "partner":"6pww" + "partner":"6das" }, { "sim":203.0, - "partner":"6dar" + "partner":"6ucs" }, { "sim":203.0, - "partner":"6das" + "partner":"2o9k" }, { "sim":203.0, - "partner":"2o9k" + "partner":"6d9x" }, { "sim":203.0, - "partner":"6ucs" + "partner":"2h9m" }, { "sim":203.0, - "partner":"6d9x" + "partner":"6ofz" }, { "sim":203.0, - "partner":"2h9m" + "partner":"6ujj" + }, + { + "sim":203.0, + "partner":"2h9n" + }, + { + "sim":203.0, + "partner":"6e1y" + }, + { + "sim":203.0, + "partner":"6ujl" }, { "sim":203.0, @@ -382023,10 +383377,6 @@ "sim":203.0, "partner":"3uvo" }, - { - "sim":203.0, - "partner":"2xl3" - }, { "sim":203.0, "partner":"6kiw" @@ -382051,6 +383401,10 @@ "sim":203.0, "partner":"6kix" }, + { + "sim":203.0, + "partner":"2xl3" + }, { "sim":203.0, "partner":"2gnq" @@ -382079,6 +383433,10 @@ "sim":191.0, "partner":"5yzv" }, + { + "sim":188.0, + "partner":"8rl2" + }, { "sim":182.0, "partner":"3v7d" @@ -382095,10 +383453,6 @@ "sim":169.0, "partner":"4wjv" }, - { - "sim":169.0, - "partner":"7btb" - }, { "sim":169.0, "partner":"4v7f" @@ -382109,35 +383463,39 @@ }, { "sim":169.0, - "partner":"3jct" + "partner":"7bt6" }, { "sim":169.0, - "partner":"5jcs" + "partner":"6ft6" }, { "sim":169.0, - "partner":"7bt6" + "partner":"6ylh" }, { "sim":169.0, - "partner":"6ft6" + "partner":"3jct" }, { "sim":169.0, - "partner":"6ylh" + "partner":"5jcs" }, { "sim":169.0, "partner":"6m62" }, + { + "sim":169.0, + "partner":"6ylg" + }, { "sim":169.0, "partner":"4wju" }, { "sim":169.0, - "partner":"6ylg" + "partner":"7btb" }, { "sim":159.0, @@ -382161,11 +383519,11 @@ }, { "sim":151.0, - "partner":"6ah0" + "partner":"6ff7" }, { "sim":151.0, - "partner":"6ff7" + "partner":"6ah0" }, { "sim":151.0, @@ -382173,15 +383531,15 @@ }, { "sim":151.0, - "partner":"5xjc" + "partner":"6icz" }, { "sim":151.0, - "partner":"5z57" + "partner":"5xjc" }, { "sim":151.0, - "partner":"6icz" + "partner":"5z57" }, { "sim":151.0, @@ -382193,11 +383551,11 @@ }, { "sim":151.0, - "partner":"5z56" + "partner":"6qw6" }, { "sim":151.0, - "partner":"6qw6" + "partner":"5z56" }, { "sim":151.0, @@ -382205,15 +383563,15 @@ }, { "sim":151.0, - "partner":"5o9z" + "partner":"6qx9" }, { "sim":151.0, - "partner":"5yzg" + "partner":"5o9z" }, { "sim":151.0, - "partner":"6qx9" + "partner":"5yzg" }, { "sim":151.0, @@ -382237,15 +383595,7 @@ }, { "sim":149.0, - "partner":"5ukk" - }, - { - "sim":149.0, - "partner":"7k7z" - }, - { - "sim":149.0, - "partner":"7jjo" + "partner":"8wgb" }, { "sim":149.0, @@ -382271,17 +383621,13 @@ "sim":149.0, "partner":"7k7l" }, - { - "sim":149.0, - "partner":"5he2" - }, { "sim":149.0, "partner":"6g79" }, { "sim":149.0, - "partner":"8wgb" + "partner":"5he2" }, { "sim":149.0, @@ -382289,27 +383635,27 @@ }, { "sim":149.0, - "partner":"6wi9" + "partner":"5ukk" }, { "sim":149.0, - "partner":"4kfm" + "partner":"7k7z" }, { "sim":149.0, - "partner":"6x18" + "partner":"7jjo" }, { "sim":149.0, - "partner":"5kdo" + "partner":"7dhr" }, { "sim":149.0, - "partner":"7dhr" + "partner":"8k4s" }, { "sim":149.0, - "partner":"3v5w" + "partner":"5kdo" }, { "sim":149.0, @@ -382323,37 +383669,49 @@ "sim":149.0, "partner":"6x19" }, + { + "sim":149.0, + "partner":"3v5w" + }, + { + "sim":149.0, + "partner":"8p15" + }, { "sim":149.0, "partner":"6niy" }, + { + "sim":149.0, + "partner":"8vve" + }, { "sim":149.0, "partner":"6x1a" }, { "sim":149.0, - "partner":"8k4s" + "partner":"8vvf" }, { "sim":149.0, - "partner":"1gg2" + "partner":"6c2y" }, { "sim":149.0, - "partner":"3pvu" + "partner":"6kpf" }, { "sim":149.0, - "partner":"4pnk" + "partner":"8zjg" }, { "sim":149.0, - "partner":"6c2y" + "partner":"3pvu" }, { "sim":149.0, - "partner":"8p12" + "partner":"4pnk" }, { "sim":149.0, @@ -382365,7 +383723,7 @@ }, { "sim":149.0, - "partner":"6kpf" + "partner":"7dhi" }, { "sim":149.0, @@ -382373,24 +383731,28 @@ }, { "sim":149.0, - "partner":"1gp2" + "partner":"6whc" }, { "sim":149.0, - "partner":"5wg3" + "partner":"8vvg" }, { "sim":149.0, - "partner":"6whc" + "partner":"1gg2" }, { "sim":149.0, - "partner":"7dhi" + "partner":"5wg3" }, { "sim":149.0, "partner":"3psc" }, + { + "sim":149.0, + "partner":"6wzg" + }, { "sim":149.0, "partner":"1omw" @@ -382401,7 +383763,7 @@ }, { "sim":149.0, - "partner":"8p13" + "partner":"1gp2" }, { "sim":149.0, @@ -382413,15 +383775,27 @@ }, { "sim":149.0, - "partner":"6wzg" + "partner":"1xhm" }, { "sim":149.0, - "partner":"1xhm" + "partner":"3pvw" }, { "sim":149.0, - "partner":"3pvw" + "partner":"6qno" + }, + { + "sim":149.0, + "partner":"6rmv" + }, + { + "sim":149.0, + "partner":"8p12" + }, + { + "sim":149.0, + "partner":"8xqe" }, { "sim":149.0, @@ -382433,11 +383807,11 @@ }, { "sim":149.0, - "partner":"6qno" + "partner":"6li3" }, { "sim":149.0, - "partner":"6rmv" + "partner":"8z7j" }, { "sim":149.0, @@ -382445,19 +383819,27 @@ }, { "sim":149.0, - "partner":"6li3" + "partner":"6u7c" }, { "sim":149.0, - "partner":"8p15" + "partner":"6wi9" }, { "sim":149.0, - "partner":"6u7c" + "partner":"6x18" }, { "sim":149.0, - "partner":"6m1h" + "partner":"8p13" + }, + { + "sim":149.0, + "partner":"8xqf" + }, + { + "sim":149.0, + "partner":"4kfm" }, { "sim":149.0, @@ -382465,11 +383847,11 @@ }, { "sim":149.0, - "partner":"5tdh" + "partner":"6m1h" }, { "sim":149.0, - "partner":"6xbk" + "partner":"5tdh" }, { "sim":149.0, @@ -382505,11 +383887,7 @@ }, { "sim":149.0, - "partner":"6nbi" - }, - { - "sim":149.0, - "partner":"6oij" + "partner":"6xbk" }, { "sim":149.0, @@ -382547,6 +383925,14 @@ "sim":149.0, "partner":"6crk" }, + { + "sim":149.0, + "partner":"6nbi" + }, + { + "sim":149.0, + "partner":"6oij" + }, { "sim":149.0, "partner":"6lfm" @@ -382565,59 +383951,59 @@ }, { "sim":149.0, - "partner":"6d9h" + "partner":"6vcb" }, { "sim":149.0, - "partner":"6p9x" + "partner":"6p9y" }, { "sim":149.0, - "partner":"6uva" + "partner":"8xx3" }, { "sim":149.0, - "partner":"6k42" + "partner":"5ukm" }, { "sim":149.0, - "partner":"6xox" + "partner":"6e3y" }, { "sim":149.0, - "partner":"6vcb" + "partner":"6m8s" }, { "sim":149.0, - "partner":"5ukm" + "partner":"6ni3" }, { "sim":149.0, - "partner":"6p9y" + "partner":"7c2e" }, { "sim":149.0, - "partner":"6e3y" + "partner":"8xx7" }, { "sim":149.0, - "partner":"6m8s" + "partner":"8xwv" }, { "sim":149.0, - "partner":"6ni3" + "partner":"8xxh" }, { "sim":149.0, - "partner":"7c2e" + "partner":"6b3j" }, { "sim":149.0, - "partner":"6b3j" + "partner":"6orv" }, { "sim":149.0, - "partner":"6orv" + "partner":"8tyw" }, { "sim":149.0, @@ -382625,12 +384011,44 @@ }, { "sim":149.0, - "partner":"8tyw" + "partner":"8jzp" + }, + { + "sim":149.0, + "partner":"8xxx" }, { "sim":149.0, "partner":"6uun" }, + { + "sim":149.0, + "partner":"8xxr" + }, + { + "sim":149.0, + "partner":"6d9h" + }, + { + "sim":149.0, + "partner":"6p9x" + }, + { + "sim":149.0, + "partner":"6uva" + }, + { + "sim":149.0, + "partner":"8xx6" + }, + { + "sim":149.0, + "partner":"6k42" + }, + { + "sim":149.0, + "partner":"6xox" + }, { "sim":149.0, "partner":"5vai" @@ -382701,12 +384119,24 @@ }, { "sim":149.0, - "partner":"7d68" + "partner":"8zfz" }, { "sim":149.0, "partner":"8vhf" }, + { + "sim":149.0, + "partner":"7d68" + }, + { + "sim":149.0, + "partner":"8wwi" + }, + { + "sim":149.0, + "partner":"8wwj" + }, { "sim":149.0, "partner":"8wwk" @@ -382729,15 +384159,11 @@ }, { "sim":149.0, - "partner":"8wwi" - }, - { - "sim":149.0, - "partner":"8wwj" + "partner":"6vn7" }, { "sim":149.0, - "partner":"6vn7" + "partner":"8jsr" }, { "sim":149.0, @@ -382777,11 +384203,11 @@ }, { "sim":147.0, - "partner":"1got" + "partner":"2trc" }, { "sim":147.0, - "partner":"2trc" + "partner":"1got" }, { "sim":147.0, @@ -382821,11 +384247,11 @@ }, { "sim":147.0, - "partner":"6t9k" + "partner":"6t9i" }, { "sim":147.0, - "partner":"6t9i" + "partner":"6t9k" }, { "sim":145.0, @@ -382837,11 +384263,11 @@ }, { "sim":145.0, - "partner":"5wsg" + "partner":"6j6q" }, { "sim":145.0, - "partner":"6j6q" + "partner":"5wsg" }, { "sim":145.0, @@ -382855,6 +384281,10 @@ "sim":145.0, "partner":"5y88" }, + { + "sim":145.0, + "partner":"6j6g" + }, { "sim":145.0, "partner":"5gm6" @@ -382865,7 +384295,7 @@ }, { "sim":145.0, - "partner":"6j6g" + "partner":"6j6n" }, { "sim":145.0, @@ -382873,11 +384303,11 @@ }, { "sim":145.0, - "partner":"6j6n" + "partner":"5lqw" }, { "sim":145.0, - "partner":"5lqw" + "partner":"6j6h" }, { "sim":145.0, @@ -382887,10 +384317,6 @@ "sim":145.0, "partner":"5ylz" }, - { - "sim":145.0, - "partner":"6j6h" - }, { "sim":142.0, "partner":"5afu" @@ -383149,23 +384575,23 @@ }, { "sim":123.0, - "partner":"5oql" + "partner":"6rxz" }, { "sim":123.0, - "partner":"6rxz" + "partner":"5oql" }, { "sim":122.0, - "partner":"6i7o" + "partner":"4v7h" }, { "sim":122.0, - "partner":"4v7h" + "partner":"6zvi" }, { "sim":122.0, - "partner":"6zvi" + "partner":"6i7o" }, { "sim":122.0, @@ -383191,22 +384617,6 @@ "sim":121.0, "partner":"6wdr" }, - { - "sim":121.0, - "partner":"4u4q" - }, - { - "sim":121.0, - "partner":"5obm" - }, - { - "sim":121.0, - "partner":"4u4r" - }, - { - "sim":121.0, - "partner":"5tgm" - }, { "sim":121.0, "partner":"4u6f" @@ -383221,27 +384631,27 @@ }, { "sim":121.0, - "partner":"6woo" + "partner":"4uer" }, { "sim":121.0, - "partner":"4uer" + "partner":"6gqv" }, { "sim":121.0, - "partner":"4u4u" + "partner":"6q8y" }, { "sim":121.0, - "partner":"5mei" + "partner":"4u4u" }, { "sim":121.0, - "partner":"6gqv" + "partner":"5mei" }, { "sim":121.0, - "partner":"6q8y" + "partner":"5tgm" }, { "sim":121.0, @@ -383263,6 +384673,10 @@ "sim":121.0, "partner":"5ndv" }, + { + "sim":121.0, + "partner":"6gq1" + }, { "sim":121.0, "partner":"5ndw" @@ -383277,7 +384691,7 @@ }, { "sim":121.0, - "partner":"6gq1" + "partner":"6gqb" }, { "sim":121.0, @@ -383291,10 +384705,6 @@ "sim":121.0, "partner":"5dgv" }, - { - "sim":121.0, - "partner":"6gqb" - }, { "sim":121.0, "partner":"4u50" @@ -383305,15 +384715,15 @@ }, { "sim":121.0, - "partner":"5tbw" + "partner":"6s47" }, { "sim":121.0, - "partner":"4u51" + "partner":"5tbw" }, { "sim":121.0, - "partner":"6s47" + "partner":"4u51" }, { "sim":121.0, @@ -383365,23 +384775,19 @@ }, { "sim":121.0, - "partner":"3j6y" - }, - { - "sim":121.0, - "partner":"4v8y" + "partner":"4u4q" }, { "sim":121.0, - "partner":"6zu9" + "partner":"5obm" }, { "sim":121.0, - "partner":"5juo" + "partner":"4u4r" }, { "sim":121.0, - "partner":"8t3f" + "partner":"6woo" }, { "sim":121.0, @@ -383393,11 +384799,11 @@ }, { "sim":121.0, - "partner":"5mc6" + "partner":"8t3f" }, { "sim":121.0, - "partner":"5jus" + "partner":"5mc6" }, { "sim":121.0, @@ -383405,47 +384811,47 @@ }, { "sim":121.0, - "partner":"8p4v" + "partner":"5jus" }, { "sim":121.0, - "partner":"8t2y" + "partner":"6t7i" }, { "sim":121.0, - "partner":"6t7i" + "partner":"6rbe" }, { "sim":121.0, - "partner":"8t3a" + "partner":"6t83" }, { "sim":121.0, - "partner":"6rbe" + "partner":"3j78" }, { "sim":121.0, - "partner":"6t83" + "partner":"8t2y" }, { "sim":121.0, - "partner":"8t30" + "partner":"3rfg" }, { "sim":121.0, - "partner":"3j78" + "partner":"5juu" }, { "sim":121.0, - "partner":"3rfg" + "partner":"6snt" }, { "sim":121.0, - "partner":"5juu" + "partner":"8t3a" }, { "sim":121.0, - "partner":"8t3c" + "partner":"8t30" }, { "sim":121.0, @@ -383457,15 +384863,19 @@ }, { "sim":121.0, - "partner":"6snt" + "partner":"8t3c" }, { "sim":121.0, - "partner":"8t3e" + "partner":"4v88" }, { "sim":121.0, - "partner":"4v88" + "partner":"6xir" + }, + { + "sim":121.0, + "partner":"8p4v" }, { "sim":121.0, @@ -383473,19 +384883,23 @@ }, { "sim":121.0, - "partner":"4v6i" + "partner":"6hhq" }, { "sim":121.0, - "partner":"5jup" + "partner":"8t3e" }, { "sim":121.0, - "partner":"6xir" + "partner":"4v6i" }, { "sim":121.0, - "partner":"6hhq" + "partner":"5jup" + }, + { + "sim":121.0, + "partner":"6sv4" }, { "sim":121.0, @@ -383493,7 +384907,7 @@ }, { "sim":121.0, - "partner":"8p9a" + "partner":"6z6k" }, { "sim":121.0, @@ -383501,7 +384915,7 @@ }, { "sim":121.0, - "partner":"6sv4" + "partner":"3j77" }, { "sim":121.0, @@ -383509,15 +384923,15 @@ }, { "sim":121.0, - "partner":"6z6k" + "partner":"5jut" }, { "sim":121.0, - "partner":"3j77" + "partner":"6fai" }, { "sim":121.0, - "partner":"5jut" + "partner":"6zu9" }, { "sim":121.0, @@ -383525,31 +384939,35 @@ }, { "sim":121.0, - "partner":"6fai" + "partner":"8p9a" }, { "sim":121.0, - "partner":"8t3b" + "partner":"3j6y" }, { "sim":121.0, - "partner":"8t3d" + "partner":"4v8y" }, { "sim":121.0, - "partner":"4j0w" + "partner":"8t3b" }, { "sim":121.0, - "partner":"6nd4" + "partner":"5juo" }, { "sim":121.0, - "partner":"6ke6" + "partner":"8t3d" }, { "sim":121.0, - "partner":"6lqq" + "partner":"4j0w" + }, + { + "sim":121.0, + "partner":"6nd4" }, { "sim":121.0, @@ -383601,19 +385019,23 @@ }, { "sim":121.0, - "partner":"5wlc" + "partner":"6lqt" }, { "sim":121.0, - "partner":"6lqt" + "partner":"5wlc" }, { "sim":121.0, "partner":"6lqp" }, { - "sim":120.0, - "partner":"7a1g" + "sim":121.0, + "partner":"6ke6" + }, + { + "sim":121.0, + "partner":"6lqq" }, { "sim":120.0, @@ -383625,11 +385047,11 @@ }, { "sim":120.0, - "partner":"6t7t" + "partner":"8uti" }, { "sim":120.0, - "partner":"8ut0" + "partner":"6t7t" }, { "sim":120.0, @@ -383637,7 +385059,11 @@ }, { "sim":120.0, - "partner":"8uti" + "partner":"8ut0" + }, + { + "sim":120.0, + "partner":"7a1g" }, { "sim":120.0, @@ -383683,10 +385109,6 @@ "sim":113.0, "partner":"8oi5" }, - { - "sim":112.0, - "partner":"6olz" - }, { "sim":112.0, "partner":"6gz4" @@ -383709,7 +385131,7 @@ }, { "sim":112.0, - "partner":"6zol" + "partner":"6olz" }, { "sim":112.0, @@ -383723,6 +385145,10 @@ "sim":112.0, "partner":"6zoj" }, + { + "sim":112.0, + "partner":"6zol" + }, { "sim":112.0, "partner":"4aow" @@ -383765,311 +385191,311 @@ }, { "sim":111.0, - "partner":"5lzv" + "partner":"4ujd" }, { "sim":111.0, - "partner":"6zmw" + "partner":"4uje" }, { "sim":111.0, - "partner":"7jqc" + "partner":"6p5j" }, { "sim":111.0, - "partner":"4kzx" + "partner":"4kzy" }, { "sim":111.0, - "partner":"6ip6" + "partner":"4ug0" }, { "sim":111.0, - "partner":"6p5n" + "partner":"5lzy" }, { "sim":111.0, - "partner":"6w2t" + "partner":"6zxh" }, { "sim":111.0, - "partner":"6zxg" + "partner":"3j7p" }, { "sim":111.0, - "partner":"6zmi" + "partner":"6hcf" }, { "sim":111.0, - "partner":"4ujd" + "partner":"6z6l" }, { "sim":111.0, - "partner":"4uje" + "partner":"6zmo" }, { "sim":111.0, - "partner":"7a09" + "partner":"6p5k" }, { "sim":111.0, - "partner":"7k5i" + "partner":"6zm7" }, { "sim":111.0, - "partner":"4kzy" + "partner":"6zme" }, { "sim":111.0, - "partner":"4ug0" + "partner":"6zon" }, { "sim":111.0, - "partner":"5lzy" + "partner":"6zp4" }, { "sim":111.0, - "partner":"3j7p" + "partner":"3j7r" }, { "sim":111.0, - "partner":"6p5j" + "partner":"4kzz" }, { "sim":111.0, - "partner":"6zxh" + "partner":"5vyc" }, { "sim":111.0, - "partner":"6hcf" + "partner":"6hcm" }, { "sim":111.0, - "partner":"3j7r" + "partner":"6sgc" }, { "sim":111.0, - "partner":"4kzz" + "partner":"6y2l" }, { "sim":111.0, - "partner":"6z6l" + "partner":"5lzu" }, { "sim":111.0, - "partner":"6zmo" + "partner":"6ip5" }, { "sim":111.0, - "partner":"5vyc" + "partner":"5lks" }, { "sim":111.0, - "partner":"6p5k" + "partner":"6g18" }, { "sim":111.0, - "partner":"6zm7" + "partner":"6z6n" }, { "sim":111.0, - "partner":"6zme" + "partner":"6zlw" }, { "sim":111.0, - "partner":"6zon" + "partner":"5lzx" }, { "sim":111.0, - "partner":"6zp4" + "partner":"6g51" }, { "sim":111.0, - "partner":"5lzu" + "partner":"6zmt" }, { "sim":111.0, - "partner":"6hcm" + "partner":"6hcq" }, { "sim":111.0, - "partner":"6sgc" + "partner":"4ujc" }, { "sim":111.0, - "partner":"6y2l" + "partner":"4v6x" }, { "sim":111.0, - "partner":"5lks" + "partner":"6zxd" }, { "sim":111.0, - "partner":"5lzx" + "partner":"6p5i" }, { "sim":111.0, - "partner":"6ip5" + "partner":"8vft" }, { "sim":111.0, - "partner":"8vft" + "partner":"5flx" }, { "sim":111.0, - "partner":"6g18" + "partner":"6d90" }, { "sim":111.0, - "partner":"6z6n" + "partner":"6hcj" }, { "sim":111.0, - "partner":"6zlw" + "partner":"6ip8" }, { "sim":111.0, - "partner":"4ujc" + "partner":"5lzt" }, { "sim":111.0, - "partner":"4v6x" + "partner":"6d9j" }, { "sim":111.0, - "partner":"6g51" + "partner":"6p4g" }, { "sim":111.0, - "partner":"6zmt" + "partner":"6w2s" }, { "sim":111.0, - "partner":"6hcq" + "partner":"4d61" }, { "sim":111.0, - "partner":"5flx" + "partner":"6g5h" }, { "sim":111.0, - "partner":"6zxd" + "partner":"6zxe" }, { "sim":111.0, - "partner":"5lzt" + "partner":"5lzw" }, { "sim":111.0, - "partner":"6p5i" + "partner":"5t2c" }, { "sim":111.0, - "partner":"6d90" + "partner":"6g5i" }, { "sim":111.0, - "partner":"6hcj" + "partner":"6y57" }, { "sim":111.0, - "partner":"6ip8" + "partner":"5aj0" }, { "sim":111.0, - "partner":"4d61" + "partner":"6ybs" }, { "sim":111.0, - "partner":"5lzw" + "partner":"6z6m" }, { "sim":111.0, - "partner":"5t2c" + "partner":"6zxf" }, { "sim":111.0, - "partner":"6d9j" + "partner":"4d5l" }, { "sim":111.0, - "partner":"6p4g" + "partner":"6p4h" }, { "sim":111.0, - "partner":"6w2s" + "partner":"5lzz" }, { "sim":111.0, - "partner":"6g5h" + "partner":"6g53" }, { "sim":111.0, - "partner":"6zxe" + "partner":"6y0g" }, { "sim":111.0, - "partner":"5aj0" + "partner":"7jqb" }, { "sim":111.0, - "partner":"6g5i" + "partner":"4v5z" }, { "sim":111.0, - "partner":"4d5l" + "partner":"5lzs" }, { "sim":111.0, - "partner":"6y57" + "partner":"6zmw" }, { "sim":111.0, - "partner":"5lzz" + "partner":"6ip6" }, { "sim":111.0, - "partner":"6ybs" + "partner":"6p5n" }, { "sim":111.0, - "partner":"6z6m" + "partner":"6w2t" }, { "sim":111.0, - "partner":"6zxf" + "partner":"6zxg" }, { "sim":111.0, - "partner":"6p4h" + "partner":"7jqc" }, { "sim":111.0, - "partner":"4v5z" + "partner":"5lzv" }, { "sim":111.0, - "partner":"5lzs" + "partner":"6zmi" }, { "sim":111.0, - "partner":"6g53" + "partner":"4kzx" }, { "sim":111.0, - "partner":"6y0g" + "partner":"7a09" }, { "sim":111.0, - "partner":"7jqb" + "partner":"7k5i" }, { "sim":111.0, - "partner":"5vh9" + "partner":"5vlj" }, { "sim":111.0, - "partner":"5vlj" + "partner":"5vh9" }, { "sim":111.0, @@ -384091,10 +385517,6 @@ "sim":110.0, "partner":"6zvj" }, - { - "sim":110.0, - "partner":"6ole" - }, { "sim":110.0, "partner":"6om7" @@ -384113,28 +385535,12 @@ }, { "sim":110.0, - "partner":"6yam" - }, - { - "sim":110.0, - "partner":"6fec" - }, - { - "sim":110.0, - "partner":"6mtb" - }, - { - "sim":110.0, - "partner":"6zvh" + "partner":"6ole" }, { "sim":110.0, "partner":"3jaj" }, - { - "sim":110.0, - "partner":"8ukb" - }, { "sim":110.0, "partner":"6r6g" @@ -384145,11 +385551,11 @@ }, { "sim":110.0, - "partner":"3jai" + "partner":"6r6p" }, { "sim":110.0, - "partner":"6r6p" + "partner":"3jai" }, { "sim":110.0, @@ -384165,12 +385571,16 @@ }, { "sim":110.0, - "partner":"3jah" + "partner":"8ukb" }, { "sim":110.0, "partner":"6mtc" }, + { + "sim":110.0, + "partner":"3jah" + }, { "sim":110.0, "partner":"6r5q" @@ -384195,10 +385605,26 @@ "sim":110.0, "partner":"3jag" }, + { + "sim":110.0, + "partner":"6yam" + }, { "sim":110.0, "partner":"3jan" }, + { + "sim":110.0, + "partner":"6fec" + }, + { + "sim":110.0, + "partner":"6mtb" + }, + { + "sim":110.0, + "partner":"6zvh" + }, { "sim":109.0, "partner":"4d6v" @@ -384209,11 +385635,11 @@ }, { "sim":106.0, - "partner":"6uh5" + "partner":"6ugm" }, { "sim":106.0, - "partner":"6ugm" + "partner":"6uh5" }, { "sim":105.0, @@ -384281,35 +385707,35 @@ }, { "sim":94.0, - "partner":"3jam" + "partner":"6fyx" }, { "sim":94.0, - "partner":"3jap" + "partner":"6uz7" }, { "sim":94.0, - "partner":"6fyy" + "partner":"3j80" }, { "sim":94.0, - "partner":"3j80" + "partner":"3j81" }, { "sim":94.0, - "partner":"6fyx" + "partner":"8s8k" }, { "sim":94.0, - "partner":"6uz7" + "partner":"3jam" }, { "sim":94.0, - "partner":"3j81" + "partner":"3jap" }, { "sim":94.0, - "partner":"8s8k" + "partner":"6fyy" }, { "sim":94.0, @@ -384337,35 +385763,35 @@ }, { "sim":93.0, - "partner":"6qtv" + "partner":"6qto" }, { "sim":93.0, - "partner":"6qtw" + "partner":"6qtq" }, { "sim":93.0, - "partner":"6qtx" + "partner":"6qtr" }, { "sim":93.0, - "partner":"6qto" + "partner":"6qtt" }, { "sim":93.0, - "partner":"6qtq" + "partner":"6qtu" }, { "sim":93.0, - "partner":"6qtr" + "partner":"6qtv" }, { "sim":93.0, - "partner":"6qtt" + "partner":"6qtw" }, { "sim":93.0, - "partner":"6qtu" + "partner":"6qtx" }, { "sim":93.0, @@ -384377,23 +385803,23 @@ }, { "sim":93.0, - "partner":"2xu7" + "partner":"6g16" }, { "sim":93.0, - "partner":"6g16" + "partner":"7aoa" }, { "sim":93.0, - "partner":"5fxy" + "partner":"8vml" }, { "sim":93.0, - "partner":"7aoa" + "partner":"6c24" }, { "sim":93.0, - "partner":"6c24" + "partner":"5fxy" }, { "sim":93.0, @@ -384403,10 +385829,18 @@ "sim":93.0, "partner":"4pby" }, + { + "sim":93.0, + "partner":"8vmi" + }, { "sim":93.0, "partner":"4pbz" }, + { + "sim":93.0, + "partner":"8vnv" + }, { "sim":93.0, "partner":"4pc0" @@ -384415,13 +385849,21 @@ "sim":93.0, "partner":"6c23" }, + { + "sim":93.0, + "partner":"6zrd" + }, + { + "sim":93.0, + "partner":"8vnz" + }, { "sim":93.0, "partner":"3gfc" }, { "sim":93.0, - "partner":"6zrd" + "partner":"2xu7" }, { "sim":93.0, @@ -384441,15 +385883,15 @@ }, { "sim":93.0, - "partner":"6nq3" + "partner":"5wai" }, { "sim":93.0, - "partner":"5wai" + "partner":"5wak" }, { "sim":93.0, - "partner":"5wak" + "partner":"6nq3" }, { "sim":93.0, @@ -384461,11 +385903,11 @@ }, { "sim":93.0, - "partner":"5xxq" + "partner":"5y1u" }, { "sim":93.0, - "partner":"5y1u" + "partner":"5xxq" }, { "sim":92.0, @@ -384491,21 +385933,13 @@ "sim":91.0, "partner":"6tc0" }, - { - "sim":91.0, - "partner":"4v5o" - }, { "sim":91.0, "partner":"4bts" }, { - "sim":89.0, - "partner":"5flc" - }, - { - "sim":89.0, - "partner":"6sb0" + "sim":91.0, + "partner":"4v5o" }, { "sim":89.0, @@ -384545,11 +385979,11 @@ }, { "sim":89.0, - "partner":"4jt6" + "partner":"6zwo" }, { "sim":89.0, - "partner":"6zwo" + "partner":"4jt6" }, { "sim":89.0, @@ -384561,12 +385995,20 @@ }, { "sim":89.0, - "partner":"5wbu" + "partner":"6sb0" + }, + { + "sim":89.0, + "partner":"5flc" }, { "sim":89.0, "partner":"5wby" }, + { + "sim":89.0, + "partner":"5wbu" + }, { "sim":89.0, "partner":"5igq" @@ -384681,11 +386123,11 @@ }, { "sim":75.0, - "partner":"2aq5" + "partner":"2b4e" }, { "sim":75.0, - "partner":"2b4e" + "partner":"2aq5" }, { "sim":74.0, @@ -384693,11 +386135,11 @@ }, { "sim":74.0, - "partner":"1gxr" + "partner":"2ce8" }, { "sim":74.0, - "partner":"2ce8" + "partner":"1gxr" }, { "sim":74.0, @@ -384721,11 +386163,11 @@ }, { "sim":73.0, - "partner":"5m2n" + "partner":"6qk7" }, { "sim":73.0, - "partner":"6qk7" + "partner":"5m2n" }, { "sim":73.0, @@ -384749,11 +386191,11 @@ }, { "sim":71.0, - "partner":"1pev" + "partner":"1nr0" }, { "sim":71.0, - "partner":"1nr0" + "partner":"1pev" }, { "sim":70.0, @@ -384837,47 +386279,47 @@ }, { "sim":59.0, - "partner":"4x63" + "partner":"4x60" }, { "sim":59.0, - "partner":"6uxx" + "partner":"4x61" }, { "sim":59.0, - "partner":"6uxy" + "partner":"5c9z" }, { "sim":59.0, - "partner":"4x60" + "partner":"5emj" }, { "sim":59.0, - "partner":"4x61" + "partner":"6k1s" }, { "sim":59.0, - "partner":"5c9z" + "partner":"5emk" }, { "sim":59.0, - "partner":"5emj" + "partner":"5eml" }, { "sim":59.0, - "partner":"5emk" + "partner":"5emm" }, { "sim":59.0, - "partner":"6k1s" + "partner":"6uxx" }, { "sim":59.0, - "partner":"5eml" + "partner":"4x63" }, { "sim":59.0, - "partner":"5emm" + "partner":"6uxy" }, { "sim":59.0, @@ -384891,14 +386333,6 @@ "sim":58.0, "partner":"4ycz" }, - { - "sim":57.0, - "partner":"5m5g" - }, - { - "sim":57.0, - "partner":"5wfd" - }, { "sim":57.0, "partner":"5bjs" @@ -384931,6 +386365,14 @@ "sim":57.0, "partner":"5wfc" }, + { + "sim":57.0, + "partner":"5m5g" + }, + { + "sim":57.0, + "partner":"5wfd" + }, { "sim":55.0, "partner":"5gva" @@ -384971,7 +386413,7 @@ ], "seq_max_sim_designed":{ "sim":645.0, - "partner":"6g6n" + "partner":"6g6m" }, "seq_max_sim_natural":{ "sim":323.0, @@ -385037,13 +386479,13 @@ ], "subtitle":"The complex between the eight-bladed symmetrical designer protein tako8 and 1:2 zirconium(iv) wells-dawson (zrwd)", "tags":[ - "framework", - "hybrid", - "designer protein", - "zrwd", - "de novo protein", "pom", - "polyoxometalate" + "de novo protein", + "polyoxometalate", + "zrwd", + "hybrid", + "framework", + "designer protein" ], "keywords":[ "description", @@ -385080,7 +386522,7 @@ "seq_thr_sim_designed":[ { "sim":649.0, - "partner":"6g6n" + "partner":"6g6m" }, { "sim":649.0, @@ -385088,7 +386530,7 @@ }, { "sim":649.0, - "partner":"6g6m" + "partner":"6g6n" }, { "sim":646.0, @@ -385156,10 +386598,6 @@ "sim":243.0, "partner":"6wnx" }, - { - "sim":243.0, - "partner":"6m90" - }, { "sim":243.0, "partner":"6m91" @@ -385176,6 +386614,10 @@ "sim":243.0, "partner":"6m94" }, + { + "sim":243.0, + "partner":"6m90" + }, { "sim":243.0, "partner":"1p22" @@ -385218,51 +386660,47 @@ }, { "sim":203.0, - "partner":"6u8l" - }, - { - "sim":203.0, - "partner":"6u5m" + "partner":"6uj4" }, { "sim":203.0, - "partner":"6uhy" + "partner":"6uif" }, { "sim":203.0, - "partner":"6uoz" + "partner":"6u5y" }, { "sim":203.0, - "partner":"6uhz" + "partner":"6uik" }, { "sim":203.0, - "partner":"6uj4" + "partner":"6u8o" }, { "sim":203.0, - "partner":"6uif" + "partner":"6dy7" }, { "sim":203.0, - "partner":"6u5y" + "partner":"6u8l" }, { "sim":203.0, - "partner":"6uik" + "partner":"6u5m" }, { "sim":203.0, - "partner":"6u8o" + "partner":"6uhy" }, { "sim":203.0, - "partner":"6dy7" + "partner":"6uoz" }, { "sim":203.0, - "partner":"6pgf" + "partner":"6uhz" }, { "sim":203.0, @@ -385302,23 +386740,19 @@ }, { "sim":203.0, - "partner":"6iam" - }, - { - "sim":203.0, - "partner":"6byn" + "partner":"6pgf" }, { "sim":203.0, - "partner":"2g99" + "partner":"6iam" }, { "sim":203.0, - "partner":"5vfc" + "partner":"6byn" }, { "sim":203.0, - "partner":"6u6w" + "partner":"2g99" }, { "sim":203.0, @@ -385334,11 +386768,11 @@ }, { "sim":203.0, - "partner":"2h6k" + "partner":"6u6w" }, { "sim":203.0, - "partner":"5eap" + "partner":"5vfc" }, { "sim":203.0, @@ -385418,31 +386852,27 @@ }, { "sim":203.0, - "partner":"2h9n" - }, - { - "sim":203.0, - "partner":"6ofz" + "partner":"2h6k" }, { "sim":203.0, - "partner":"6ujj" + "partner":"5eap" }, { "sim":203.0, - "partner":"6e1y" + "partner":"6dai" }, { "sim":203.0, - "partner":"6ujl" + "partner":"6e1z" }, { "sim":203.0, - "partner":"6e1z" + "partner":"6pwv" }, { "sim":203.0, - "partner":"6dai" + "partner":"6dak" }, { "sim":203.0, @@ -385450,23 +386880,23 @@ }, { "sim":203.0, - "partner":"6pwv" + "partner":"6e22" }, { "sim":203.0, - "partner":"6dak" + "partner":"6e23" }, { "sim":203.0, - "partner":"6e22" + "partner":"6oi0" }, { "sim":203.0, - "partner":"6e23" + "partner":"6oi1" }, { "sim":203.0, - "partner":"6oi0" + "partner":"6oi2" }, { "sim":203.0, @@ -385474,7 +386904,7 @@ }, { "sim":203.0, - "partner":"6oi1" + "partner":"6oi3" }, { "sim":203.0, @@ -385486,15 +386916,15 @@ }, { "sim":203.0, - "partner":"6oi2" + "partner":"6ujh" }, { "sim":203.0, - "partner":"6oi3" + "partner":"6pww" }, { "sim":203.0, - "partner":"6ujh" + "partner":"6dar" }, { "sim":203.0, @@ -385502,31 +386932,43 @@ }, { "sim":203.0, - "partner":"6pww" + "partner":"6das" }, { "sim":203.0, - "partner":"6dar" + "partner":"6ucs" }, { "sim":203.0, - "partner":"6das" + "partner":"2o9k" }, { "sim":203.0, - "partner":"2o9k" + "partner":"6d9x" }, { "sim":203.0, - "partner":"6ucs" + "partner":"2h9m" }, { "sim":203.0, - "partner":"6d9x" + "partner":"6ofz" }, { "sim":203.0, - "partner":"2h9m" + "partner":"6ujj" + }, + { + "sim":203.0, + "partner":"2h9n" + }, + { + "sim":203.0, + "partner":"6e1y" + }, + { + "sim":203.0, + "partner":"6ujl" }, { "sim":203.0, @@ -385604,10 +387046,6 @@ "sim":203.0, "partner":"3uvo" }, - { - "sim":203.0, - "partner":"2xl3" - }, { "sim":203.0, "partner":"6kiw" @@ -385632,6 +387070,10 @@ "sim":203.0, "partner":"6kix" }, + { + "sim":203.0, + "partner":"2xl3" + }, { "sim":203.0, "partner":"2gnq" @@ -385660,6 +387102,10 @@ "sim":191.0, "partner":"5yzv" }, + { + "sim":188.0, + "partner":"8rl2" + }, { "sim":182.0, "partner":"3v7d" @@ -385672,10 +387118,6 @@ "sim":182.0, "partner":"1nex" }, - { - "sim":168.0, - "partner":"7btb" - }, { "sim":168.0, "partner":"4v7f" @@ -385686,35 +387128,39 @@ }, { "sim":168.0, - "partner":"3jct" + "partner":"7bt6" }, { "sim":168.0, - "partner":"5jcs" + "partner":"6ft6" }, { "sim":168.0, - "partner":"7bt6" + "partner":"6ylh" }, { "sim":168.0, - "partner":"6ft6" + "partner":"3jct" }, { "sim":168.0, - "partner":"6ylh" + "partner":"5jcs" }, { "sim":168.0, "partner":"6m62" }, + { + "sim":168.0, + "partner":"6ylg" + }, { "sim":168.0, "partner":"4wju" }, { "sim":168.0, - "partner":"6ylg" + "partner":"7btb" }, { "sim":167.0, @@ -385742,11 +387188,11 @@ }, { "sim":151.0, - "partner":"6ah0" + "partner":"6ff7" }, { "sim":151.0, - "partner":"6ff7" + "partner":"6ah0" }, { "sim":151.0, @@ -385754,15 +387200,15 @@ }, { "sim":151.0, - "partner":"5xjc" + "partner":"6icz" }, { "sim":151.0, - "partner":"5z57" + "partner":"5xjc" }, { "sim":151.0, - "partner":"6icz" + "partner":"5z57" }, { "sim":151.0, @@ -385774,11 +387220,11 @@ }, { "sim":151.0, - "partner":"5z56" + "partner":"6qw6" }, { "sim":151.0, - "partner":"6qw6" + "partner":"5z56" }, { "sim":151.0, @@ -385786,15 +387232,15 @@ }, { "sim":151.0, - "partner":"5o9z" + "partner":"6qx9" }, { "sim":151.0, - "partner":"5yzg" + "partner":"5o9z" }, { "sim":151.0, - "partner":"6qx9" + "partner":"5yzg" }, { "sim":151.0, @@ -385818,15 +387264,7 @@ }, { "sim":149.0, - "partner":"5ukk" - }, - { - "sim":149.0, - "partner":"7k7z" - }, - { - "sim":149.0, - "partner":"7jjo" + "partner":"8wgb" }, { "sim":149.0, @@ -385852,17 +387290,13 @@ "sim":149.0, "partner":"7k7l" }, - { - "sim":149.0, - "partner":"5he2" - }, { "sim":149.0, "partner":"6g79" }, { "sim":149.0, - "partner":"8wgb" + "partner":"5he2" }, { "sim":149.0, @@ -385870,27 +387304,27 @@ }, { "sim":149.0, - "partner":"6wi9" + "partner":"5ukk" }, { "sim":149.0, - "partner":"4kfm" + "partner":"7k7z" }, { "sim":149.0, - "partner":"6x18" + "partner":"7jjo" }, { "sim":149.0, - "partner":"5kdo" + "partner":"7dhr" }, { "sim":149.0, - "partner":"7dhr" + "partner":"8k4s" }, { "sim":149.0, - "partner":"3v5w" + "partner":"5kdo" }, { "sim":149.0, @@ -385904,37 +387338,49 @@ "sim":149.0, "partner":"6x19" }, + { + "sim":149.0, + "partner":"3v5w" + }, + { + "sim":149.0, + "partner":"8p15" + }, { "sim":149.0, "partner":"6niy" }, + { + "sim":149.0, + "partner":"8vve" + }, { "sim":149.0, "partner":"6x1a" }, { "sim":149.0, - "partner":"8k4s" + "partner":"8vvf" }, { "sim":149.0, - "partner":"1gg2" + "partner":"6c2y" }, { "sim":149.0, - "partner":"3pvu" + "partner":"6kpf" }, { "sim":149.0, - "partner":"4pnk" + "partner":"8zjg" }, { "sim":149.0, - "partner":"6c2y" + "partner":"3pvu" }, { "sim":149.0, - "partner":"8p12" + "partner":"4pnk" }, { "sim":149.0, @@ -385946,7 +387392,7 @@ }, { "sim":149.0, - "partner":"6kpf" + "partner":"7dhi" }, { "sim":149.0, @@ -385954,24 +387400,28 @@ }, { "sim":149.0, - "partner":"1gp2" + "partner":"6whc" }, { "sim":149.0, - "partner":"5wg3" + "partner":"8vvg" }, { "sim":149.0, - "partner":"6whc" + "partner":"1gg2" }, { "sim":149.0, - "partner":"7dhi" + "partner":"5wg3" }, { "sim":149.0, "partner":"3psc" }, + { + "sim":149.0, + "partner":"6wzg" + }, { "sim":149.0, "partner":"1omw" @@ -385982,7 +387432,7 @@ }, { "sim":149.0, - "partner":"8p13" + "partner":"1gp2" }, { "sim":149.0, @@ -385994,15 +387444,27 @@ }, { "sim":149.0, - "partner":"6wzg" + "partner":"1xhm" }, { "sim":149.0, - "partner":"1xhm" + "partner":"3pvw" }, { "sim":149.0, - "partner":"3pvw" + "partner":"6qno" + }, + { + "sim":149.0, + "partner":"6rmv" + }, + { + "sim":149.0, + "partner":"8p12" + }, + { + "sim":149.0, + "partner":"8xqe" }, { "sim":149.0, @@ -386014,11 +387476,11 @@ }, { "sim":149.0, - "partner":"6qno" + "partner":"6li3" }, { "sim":149.0, - "partner":"6rmv" + "partner":"8z7j" }, { "sim":149.0, @@ -386026,19 +387488,27 @@ }, { "sim":149.0, - "partner":"6li3" + "partner":"6u7c" }, { "sim":149.0, - "partner":"8p15" + "partner":"6wi9" }, { "sim":149.0, - "partner":"6u7c" + "partner":"6x18" }, { "sim":149.0, - "partner":"6m1h" + "partner":"8p13" + }, + { + "sim":149.0, + "partner":"8xqf" + }, + { + "sim":149.0, + "partner":"4kfm" }, { "sim":149.0, @@ -386046,11 +387516,11 @@ }, { "sim":149.0, - "partner":"5tdh" + "partner":"6m1h" }, { "sim":149.0, - "partner":"6xbk" + "partner":"5tdh" }, { "sim":149.0, @@ -386086,11 +387556,7 @@ }, { "sim":149.0, - "partner":"6nbi" - }, - { - "sim":149.0, - "partner":"6oij" + "partner":"6xbk" }, { "sim":149.0, @@ -386128,6 +387594,14 @@ "sim":149.0, "partner":"6crk" }, + { + "sim":149.0, + "partner":"6nbi" + }, + { + "sim":149.0, + "partner":"6oij" + }, { "sim":149.0, "partner":"6lfm" @@ -386146,59 +387620,59 @@ }, { "sim":149.0, - "partner":"6d9h" + "partner":"6vcb" }, { "sim":149.0, - "partner":"6p9x" + "partner":"6p9y" }, { "sim":149.0, - "partner":"6uva" + "partner":"8xx3" }, { "sim":149.0, - "partner":"6k42" + "partner":"5ukm" }, { "sim":149.0, - "partner":"6xox" + "partner":"6e3y" }, { "sim":149.0, - "partner":"6vcb" + "partner":"6m8s" }, { "sim":149.0, - "partner":"5ukm" + "partner":"6ni3" }, { "sim":149.0, - "partner":"6p9y" + "partner":"7c2e" }, { "sim":149.0, - "partner":"6e3y" + "partner":"8xx7" }, { "sim":149.0, - "partner":"6m8s" + "partner":"8xwv" }, { "sim":149.0, - "partner":"6ni3" + "partner":"8xxh" }, { "sim":149.0, - "partner":"7c2e" + "partner":"6b3j" }, { "sim":149.0, - "partner":"6b3j" + "partner":"6orv" }, { "sim":149.0, - "partner":"6orv" + "partner":"8tyw" }, { "sim":149.0, @@ -386206,12 +387680,44 @@ }, { "sim":149.0, - "partner":"8tyw" + "partner":"8jzp" + }, + { + "sim":149.0, + "partner":"8xxx" }, { "sim":149.0, "partner":"6uun" }, + { + "sim":149.0, + "partner":"8xxr" + }, + { + "sim":149.0, + "partner":"6d9h" + }, + { + "sim":149.0, + "partner":"6p9x" + }, + { + "sim":149.0, + "partner":"6uva" + }, + { + "sim":149.0, + "partner":"8xx6" + }, + { + "sim":149.0, + "partner":"6k42" + }, + { + "sim":149.0, + "partner":"6xox" + }, { "sim":149.0, "partner":"5vai" @@ -386282,12 +387788,24 @@ }, { "sim":149.0, - "partner":"7d68" + "partner":"8zfz" }, { "sim":149.0, "partner":"8vhf" }, + { + "sim":149.0, + "partner":"7d68" + }, + { + "sim":149.0, + "partner":"8wwi" + }, + { + "sim":149.0, + "partner":"8wwj" + }, { "sim":149.0, "partner":"8wwk" @@ -386310,15 +387828,11 @@ }, { "sim":149.0, - "partner":"8wwi" - }, - { - "sim":149.0, - "partner":"8wwj" + "partner":"6vn7" }, { "sim":149.0, - "partner":"6vn7" + "partner":"8jsr" }, { "sim":149.0, @@ -386358,11 +387872,11 @@ }, { "sim":147.0, - "partner":"1got" + "partner":"2trc" }, { "sim":147.0, - "partner":"2trc" + "partner":"1got" }, { "sim":147.0, @@ -386402,11 +387916,11 @@ }, { "sim":147.0, - "partner":"6t9k" + "partner":"6t9i" }, { "sim":147.0, - "partner":"6t9i" + "partner":"6t9k" }, { "sim":145.0, @@ -386418,11 +387932,11 @@ }, { "sim":145.0, - "partner":"5wsg" + "partner":"6j6q" }, { "sim":145.0, - "partner":"6j6q" + "partner":"5wsg" }, { "sim":145.0, @@ -386436,6 +387950,10 @@ "sim":145.0, "partner":"5y88" }, + { + "sim":145.0, + "partner":"6j6g" + }, { "sim":145.0, "partner":"5gm6" @@ -386446,7 +387964,7 @@ }, { "sim":145.0, - "partner":"6j6g" + "partner":"6j6n" }, { "sim":145.0, @@ -386454,11 +387972,11 @@ }, { "sim":145.0, - "partner":"6j6n" + "partner":"5lqw" }, { "sim":145.0, - "partner":"5lqw" + "partner":"6j6h" }, { "sim":145.0, @@ -386468,10 +387986,6 @@ "sim":145.0, "partner":"5ylz" }, - { - "sim":145.0, - "partner":"6j6h" - }, { "sim":142.0, "partner":"5afu" @@ -386730,23 +388244,23 @@ }, { "sim":123.0, - "partner":"5oql" + "partner":"6rxz" }, { "sim":123.0, - "partner":"6rxz" + "partner":"5oql" }, { "sim":122.0, - "partner":"6i7o" + "partner":"4v7h" }, { "sim":122.0, - "partner":"4v7h" + "partner":"6zvi" }, { "sim":122.0, - "partner":"6zvi" + "partner":"6i7o" }, { "sim":122.0, @@ -386772,22 +388286,6 @@ "sim":121.0, "partner":"6wdr" }, - { - "sim":121.0, - "partner":"4u4q" - }, - { - "sim":121.0, - "partner":"5obm" - }, - { - "sim":121.0, - "partner":"4u4r" - }, - { - "sim":121.0, - "partner":"5tgm" - }, { "sim":121.0, "partner":"4u6f" @@ -386802,27 +388300,27 @@ }, { "sim":121.0, - "partner":"6woo" + "partner":"4uer" }, { "sim":121.0, - "partner":"4uer" + "partner":"6gqv" }, { "sim":121.0, - "partner":"4u4u" + "partner":"6q8y" }, { "sim":121.0, - "partner":"5mei" + "partner":"4u4u" }, { "sim":121.0, - "partner":"6gqv" + "partner":"5mei" }, { "sim":121.0, - "partner":"6q8y" + "partner":"5tgm" }, { "sim":121.0, @@ -386844,6 +388342,10 @@ "sim":121.0, "partner":"5ndv" }, + { + "sim":121.0, + "partner":"6gq1" + }, { "sim":121.0, "partner":"5ndw" @@ -386858,7 +388360,7 @@ }, { "sim":121.0, - "partner":"6gq1" + "partner":"6gqb" }, { "sim":121.0, @@ -386872,10 +388374,6 @@ "sim":121.0, "partner":"5dgv" }, - { - "sim":121.0, - "partner":"6gqb" - }, { "sim":121.0, "partner":"4u50" @@ -386886,15 +388384,15 @@ }, { "sim":121.0, - "partner":"5tbw" + "partner":"6s47" }, { "sim":121.0, - "partner":"4u51" + "partner":"5tbw" }, { "sim":121.0, - "partner":"6s47" + "partner":"4u51" }, { "sim":121.0, @@ -386946,23 +388444,19 @@ }, { "sim":121.0, - "partner":"3j6y" - }, - { - "sim":121.0, - "partner":"4v8y" + "partner":"4u4q" }, { "sim":121.0, - "partner":"6zu9" + "partner":"5obm" }, { "sim":121.0, - "partner":"5juo" + "partner":"4u4r" }, { "sim":121.0, - "partner":"8t3f" + "partner":"6woo" }, { "sim":121.0, @@ -386974,11 +388468,11 @@ }, { "sim":121.0, - "partner":"5mc6" + "partner":"8t3f" }, { "sim":121.0, - "partner":"5jus" + "partner":"5mc6" }, { "sim":121.0, @@ -386986,47 +388480,47 @@ }, { "sim":121.0, - "partner":"8p4v" + "partner":"5jus" }, { "sim":121.0, - "partner":"8t2y" + "partner":"6t7i" }, { "sim":121.0, - "partner":"6t7i" + "partner":"6rbe" }, { "sim":121.0, - "partner":"8t3a" + "partner":"6t83" }, { "sim":121.0, - "partner":"6rbe" + "partner":"3j78" }, { "sim":121.0, - "partner":"6t83" + "partner":"8t2y" }, { "sim":121.0, - "partner":"8t30" + "partner":"3rfg" }, { "sim":121.0, - "partner":"3j78" + "partner":"5juu" }, { "sim":121.0, - "partner":"3rfg" + "partner":"6snt" }, { "sim":121.0, - "partner":"5juu" + "partner":"8t3a" }, { "sim":121.0, - "partner":"8t3c" + "partner":"8t30" }, { "sim":121.0, @@ -387038,15 +388532,19 @@ }, { "sim":121.0, - "partner":"6snt" + "partner":"8t3c" }, { "sim":121.0, - "partner":"8t3e" + "partner":"4v88" }, { "sim":121.0, - "partner":"4v88" + "partner":"6xir" + }, + { + "sim":121.0, + "partner":"8p4v" }, { "sim":121.0, @@ -387054,19 +388552,23 @@ }, { "sim":121.0, - "partner":"4v6i" + "partner":"6hhq" }, { "sim":121.0, - "partner":"5jup" + "partner":"8t3e" }, { "sim":121.0, - "partner":"6xir" + "partner":"4v6i" }, { "sim":121.0, - "partner":"6hhq" + "partner":"5jup" + }, + { + "sim":121.0, + "partner":"6sv4" }, { "sim":121.0, @@ -387074,7 +388576,7 @@ }, { "sim":121.0, - "partner":"8p9a" + "partner":"6z6k" }, { "sim":121.0, @@ -387082,7 +388584,7 @@ }, { "sim":121.0, - "partner":"6sv4" + "partner":"3j77" }, { "sim":121.0, @@ -387090,15 +388592,15 @@ }, { "sim":121.0, - "partner":"6z6k" + "partner":"5jut" }, { "sim":121.0, - "partner":"3j77" + "partner":"6fai" }, { "sim":121.0, - "partner":"5jut" + "partner":"6zu9" }, { "sim":121.0, @@ -387106,31 +388608,35 @@ }, { "sim":121.0, - "partner":"6fai" + "partner":"8p9a" }, { "sim":121.0, - "partner":"8t3b" + "partner":"3j6y" }, { "sim":121.0, - "partner":"8t3d" + "partner":"4v8y" }, { "sim":121.0, - "partner":"4j0w" + "partner":"8t3b" }, { "sim":121.0, - "partner":"6nd4" + "partner":"5juo" }, { "sim":121.0, - "partner":"6ke6" + "partner":"8t3d" }, { "sim":121.0, - "partner":"6lqq" + "partner":"4j0w" + }, + { + "sim":121.0, + "partner":"6nd4" }, { "sim":121.0, @@ -387182,19 +388688,23 @@ }, { "sim":121.0, - "partner":"5wlc" + "partner":"6lqt" }, { "sim":121.0, - "partner":"6lqt" + "partner":"5wlc" }, { "sim":121.0, "partner":"6lqp" }, { - "sim":120.0, - "partner":"7a1g" + "sim":121.0, + "partner":"6ke6" + }, + { + "sim":121.0, + "partner":"6lqq" }, { "sim":120.0, @@ -387206,11 +388716,11 @@ }, { "sim":120.0, - "partner":"6t7t" + "partner":"8uti" }, { "sim":120.0, - "partner":"8ut0" + "partner":"6t7t" }, { "sim":120.0, @@ -387218,7 +388728,11 @@ }, { "sim":120.0, - "partner":"8uti" + "partner":"8ut0" + }, + { + "sim":120.0, + "partner":"7a1g" }, { "sim":120.0, @@ -387300,10 +388814,6 @@ "sim":113.0, "partner":"5cvo" }, - { - "sim":112.0, - "partner":"6olz" - }, { "sim":112.0, "partner":"6gz4" @@ -387326,7 +388836,7 @@ }, { "sim":112.0, - "partner":"6zol" + "partner":"6olz" }, { "sim":112.0, @@ -387342,15 +388852,15 @@ }, { "sim":112.0, - "partner":"4aow" + "partner":"6zol" }, { - "sim":111.0, - "partner":"6zvj" + "sim":112.0, + "partner":"4aow" }, { "sim":111.0, - "partner":"6ole" + "partner":"6zvj" }, { "sim":111.0, @@ -387370,28 +388880,12 @@ }, { "sim":111.0, - "partner":"6yam" - }, - { - "sim":111.0, - "partner":"6fec" - }, - { - "sim":111.0, - "partner":"6mtb" - }, - { - "sim":111.0, - "partner":"6zvh" + "partner":"6ole" }, { "sim":111.0, "partner":"3jaj" }, - { - "sim":111.0, - "partner":"8ukb" - }, { "sim":111.0, "partner":"6r6g" @@ -387402,11 +388896,11 @@ }, { "sim":111.0, - "partner":"3jai" + "partner":"6r6p" }, { "sim":111.0, - "partner":"6r6p" + "partner":"3jai" }, { "sim":111.0, @@ -387422,12 +388916,16 @@ }, { "sim":111.0, - "partner":"3jah" + "partner":"8ukb" }, { "sim":111.0, "partner":"6mtc" }, + { + "sim":111.0, + "partner":"3jah" + }, { "sim":111.0, "partner":"6r5q" @@ -387454,87 +388952,87 @@ }, { "sim":111.0, - "partner":"3jan" + "partner":"6yam" }, { "sim":111.0, - "partner":"5lzv" + "partner":"3jan" }, { "sim":111.0, - "partner":"6zmw" + "partner":"6fec" }, { "sim":111.0, - "partner":"7jqc" + "partner":"6mtb" }, { "sim":111.0, - "partner":"4kzx" + "partner":"6zvh" }, { "sim":111.0, - "partner":"6ip6" + "partner":"4ujd" }, { "sim":111.0, - "partner":"6p5n" + "partner":"4uje" }, { "sim":111.0, - "partner":"6w2t" + "partner":"6p5j" }, { "sim":111.0, - "partner":"6zxg" + "partner":"4kzy" }, { "sim":111.0, - "partner":"6zmi" + "partner":"4ug0" }, { "sim":111.0, - "partner":"4ujd" + "partner":"5lzy" }, { "sim":111.0, - "partner":"4uje" + "partner":"6zxh" }, { "sim":111.0, - "partner":"7a09" + "partner":"3j7p" }, { "sim":111.0, - "partner":"7k5i" + "partner":"6hcf" }, { "sim":111.0, - "partner":"4kzy" + "partner":"6z6l" }, { "sim":111.0, - "partner":"4ug0" + "partner":"6zmo" }, { "sim":111.0, - "partner":"5lzy" + "partner":"6p5k" }, { "sim":111.0, - "partner":"3j7p" + "partner":"6zm7" }, { "sim":111.0, - "partner":"6p5j" + "partner":"6zme" }, { "sim":111.0, - "partner":"6zxh" + "partner":"6zon" }, { "sim":111.0, - "partner":"6hcf" + "partner":"6zp4" }, { "sim":111.0, @@ -387546,63 +389044,75 @@ }, { "sim":111.0, - "partner":"6z6l" + "partner":"5vyc" }, { "sim":111.0, - "partner":"6zmo" + "partner":"6hcm" }, { "sim":111.0, - "partner":"5vyc" + "partner":"6sgc" }, { "sim":111.0, - "partner":"6p5k" + "partner":"6y2l" }, { "sim":111.0, - "partner":"6zm7" + "partner":"5lzu" }, { "sim":111.0, - "partner":"6zme" + "partner":"6ip5" }, { "sim":111.0, - "partner":"6zon" + "partner":"5lks" }, { "sim":111.0, - "partner":"6zp4" + "partner":"6g18" }, { "sim":111.0, - "partner":"5lzu" + "partner":"6z6n" }, { "sim":111.0, - "partner":"6hcm" + "partner":"6zlw" }, { "sim":111.0, - "partner":"6sgc" + "partner":"5lzx" }, { "sim":111.0, - "partner":"6y2l" + "partner":"6g51" }, { "sim":111.0, - "partner":"5lks" + "partner":"6zmt" }, { "sim":111.0, - "partner":"5lzx" + "partner":"6hcq" }, { "sim":111.0, - "partner":"6ip5" + "partner":"4ujc" + }, + { + "sim":111.0, + "partner":"4v6x" + }, + { + "sim":111.0, + "partner":"6zxd" + }, + { + "sim":111.0, + "partner":"6p5i" }, { "sim":111.0, @@ -387610,160 +389120,164 @@ }, { "sim":111.0, - "partner":"6g18" + "partner":"5flx" }, { "sim":111.0, - "partner":"6z6n" + "partner":"6d90" }, { "sim":111.0, - "partner":"6zlw" + "partner":"6hcj" }, { "sim":111.0, - "partner":"4ujc" + "partner":"6ip8" }, { "sim":111.0, - "partner":"4v6x" + "partner":"5lzt" }, { "sim":111.0, - "partner":"6g51" + "partner":"6d9j" }, { "sim":111.0, - "partner":"6zmt" + "partner":"6p4g" }, { "sim":111.0, - "partner":"6hcq" + "partner":"6w2s" }, { "sim":111.0, - "partner":"5flx" + "partner":"4d61" }, { "sim":111.0, - "partner":"6zxd" + "partner":"6g5h" }, { "sim":111.0, - "partner":"5lzt" + "partner":"6zxe" }, { "sim":111.0, - "partner":"6p5i" + "partner":"5lzw" }, { "sim":111.0, - "partner":"6d90" + "partner":"5t2c" }, { "sim":111.0, - "partner":"6hcj" + "partner":"6g5i" }, { "sim":111.0, - "partner":"6ip8" + "partner":"6y57" }, { "sim":111.0, - "partner":"4d61" + "partner":"5aj0" }, { "sim":111.0, - "partner":"5lzw" + "partner":"6ybs" }, { "sim":111.0, - "partner":"5t2c" + "partner":"6z6m" }, { "sim":111.0, - "partner":"6d9j" + "partner":"6zxf" }, { "sim":111.0, - "partner":"6p4g" + "partner":"4d5l" }, { "sim":111.0, - "partner":"6w2s" + "partner":"6p4h" }, { "sim":111.0, - "partner":"6g5h" + "partner":"5lzz" }, { "sim":111.0, - "partner":"6zxe" + "partner":"6g53" }, { "sim":111.0, - "partner":"5aj0" + "partner":"6y0g" }, { "sim":111.0, - "partner":"6g5i" + "partner":"7jqb" }, { "sim":111.0, - "partner":"4d5l" + "partner":"4v5z" }, { "sim":111.0, - "partner":"6y57" + "partner":"5lzs" }, { "sim":111.0, - "partner":"5lzz" + "partner":"6zmw" }, { "sim":111.0, - "partner":"6ybs" + "partner":"6ip6" }, { "sim":111.0, - "partner":"6z6m" + "partner":"6p5n" }, { "sim":111.0, - "partner":"6zxf" + "partner":"6w2t" }, { "sim":111.0, - "partner":"6p4h" + "partner":"6zxg" }, { "sim":111.0, - "partner":"4v5z" + "partner":"7jqc" }, { "sim":111.0, - "partner":"5lzs" + "partner":"5lzv" }, { "sim":111.0, - "partner":"6g53" + "partner":"6zmi" }, { "sim":111.0, - "partner":"6y0g" + "partner":"4kzx" }, { "sim":111.0, - "partner":"7jqb" + "partner":"7a09" }, { "sim":111.0, - "partner":"5vh9" + "partner":"7k5i" }, { "sim":111.0, "partner":"5vlj" }, + { + "sim":111.0, + "partner":"5vh9" + }, { "sim":111.0, "partner":"5wve" @@ -387790,11 +389304,11 @@ }, { "sim":106.0, - "partner":"6uh5" + "partner":"6ugm" }, { "sim":106.0, - "partner":"6ugm" + "partner":"6uh5" }, { "sim":105.0, @@ -387862,35 +389376,35 @@ }, { "sim":94.0, - "partner":"3jam" + "partner":"6fyx" }, { "sim":94.0, - "partner":"3jap" + "partner":"6uz7" }, { "sim":94.0, - "partner":"6fyy" + "partner":"3j80" }, { "sim":94.0, - "partner":"3j80" + "partner":"3j81" }, { "sim":94.0, - "partner":"6fyx" + "partner":"8s8k" }, { "sim":94.0, - "partner":"6uz7" + "partner":"3jam" }, { "sim":94.0, - "partner":"3j81" + "partner":"3jap" }, { "sim":94.0, - "partner":"8s8k" + "partner":"6fyy" }, { "sim":94.0, @@ -387918,35 +389432,35 @@ }, { "sim":93.0, - "partner":"6qtv" + "partner":"6qto" }, { "sim":93.0, - "partner":"6qtw" + "partner":"6qtq" }, { "sim":93.0, - "partner":"6qtx" + "partner":"6qtr" }, { "sim":93.0, - "partner":"6qto" + "partner":"6qtt" }, { "sim":93.0, - "partner":"6qtq" + "partner":"6qtu" }, { "sim":93.0, - "partner":"6qtr" + "partner":"6qtv" }, { "sim":93.0, - "partner":"6qtt" + "partner":"6qtw" }, { "sim":93.0, - "partner":"6qtu" + "partner":"6qtx" }, { "sim":93.0, @@ -387958,23 +389472,23 @@ }, { "sim":93.0, - "partner":"2xu7" + "partner":"6g16" }, { "sim":93.0, - "partner":"6g16" + "partner":"7aoa" }, { "sim":93.0, - "partner":"5fxy" + "partner":"8vml" }, { "sim":93.0, - "partner":"7aoa" + "partner":"6c24" }, { "sim":93.0, - "partner":"6c24" + "partner":"5fxy" }, { "sim":93.0, @@ -387984,10 +389498,18 @@ "sim":93.0, "partner":"4pby" }, + { + "sim":93.0, + "partner":"8vmi" + }, { "sim":93.0, "partner":"4pbz" }, + { + "sim":93.0, + "partner":"8vnv" + }, { "sim":93.0, "partner":"4pc0" @@ -387996,13 +389518,21 @@ "sim":93.0, "partner":"6c23" }, + { + "sim":93.0, + "partner":"6zrd" + }, + { + "sim":93.0, + "partner":"8vnz" + }, { "sim":93.0, "partner":"3gfc" }, { "sim":93.0, - "partner":"6zrd" + "partner":"2xu7" }, { "sim":93.0, @@ -388022,15 +389552,15 @@ }, { "sim":93.0, - "partner":"6nq3" + "partner":"5wai" }, { "sim":93.0, - "partner":"5wai" + "partner":"5wak" }, { "sim":93.0, - "partner":"5wak" + "partner":"6nq3" }, { "sim":93.0, @@ -388042,11 +389572,11 @@ }, { "sim":93.0, - "partner":"5xxq" + "partner":"5y1u" }, { "sim":93.0, - "partner":"5y1u" + "partner":"5xxq" }, { "sim":92.0, @@ -388072,21 +389602,13 @@ "sim":91.0, "partner":"6tc0" }, - { - "sim":90.0, - "partner":"4v5o" - }, { "sim":90.0, "partner":"4bts" }, { - "sim":89.0, - "partner":"5flc" - }, - { - "sim":89.0, - "partner":"6sb0" + "sim":90.0, + "partner":"4v5o" }, { "sim":89.0, @@ -388126,11 +389648,11 @@ }, { "sim":89.0, - "partner":"4jt6" + "partner":"6zwo" }, { "sim":89.0, - "partner":"6zwo" + "partner":"4jt6" }, { "sim":89.0, @@ -388142,12 +389664,20 @@ }, { "sim":89.0, - "partner":"5wbu" + "partner":"6sb0" + }, + { + "sim":89.0, + "partner":"5flc" }, { "sim":89.0, "partner":"5wby" }, + { + "sim":89.0, + "partner":"5wbu" + }, { "sim":89.0, "partner":"5igq" @@ -388262,11 +389792,11 @@ }, { "sim":75.0, - "partner":"2aq5" + "partner":"2b4e" }, { "sim":75.0, - "partner":"2b4e" + "partner":"2aq5" }, { "sim":74.0, @@ -388274,11 +389804,11 @@ }, { "sim":74.0, - "partner":"1gxr" + "partner":"2ce8" }, { "sim":74.0, - "partner":"2ce8" + "partner":"1gxr" }, { "sim":74.0, @@ -388302,11 +389832,11 @@ }, { "sim":73.0, - "partner":"5m2n" + "partner":"6qk7" }, { "sim":73.0, - "partner":"6qk7" + "partner":"5m2n" }, { "sim":73.0, @@ -388330,11 +389860,11 @@ }, { "sim":71.0, - "partner":"1pev" + "partner":"1nr0" }, { "sim":71.0, - "partner":"1nr0" + "partner":"1pev" }, { "sim":70.0, @@ -388388,14 +389918,6 @@ "sim":61.0, "partner":"3mmy" }, - { - "sim":60.0, - "partner":"5m5g" - }, - { - "sim":60.0, - "partner":"5wfd" - }, { "sim":60.0, "partner":"5bjs" @@ -388428,6 +389950,14 @@ "sim":60.0, "partner":"5wfc" }, + { + "sim":60.0, + "partner":"5m5g" + }, + { + "sim":60.0, + "partner":"5wfd" + }, { "sim":59.0, "partner":"6v0n" @@ -388458,47 +389988,47 @@ }, { "sim":59.0, - "partner":"4x63" + "partner":"4x60" }, { "sim":59.0, - "partner":"6uxx" + "partner":"4x61" }, { "sim":59.0, - "partner":"6uxy" + "partner":"5c9z" }, { "sim":59.0, - "partner":"4x60" + "partner":"5emj" }, { "sim":59.0, - "partner":"4x61" + "partner":"6k1s" }, { "sim":59.0, - "partner":"5c9z" + "partner":"5emk" }, { "sim":59.0, - "partner":"5emj" + "partner":"5eml" }, { "sim":59.0, - "partner":"5emk" + "partner":"5emm" }, { "sim":59.0, - "partner":"6k1s" + "partner":"6uxx" }, { "sim":59.0, - "partner":"5eml" + "partner":"4x63" }, { "sim":59.0, - "partner":"5emm" + "partner":"6uxy" }, { "sim":59.0, @@ -388552,7 +390082,7 @@ ], "seq_max_sim_designed":{ "sim":649.0, - "partner":"6g6n" + "partner":"6g6m" }, "seq_max_sim_natural":{ "sim":323.0, @@ -388663,92 +390193,92 @@ ], "subtitle":"Crystal structure of a parallel hexameric coiled coil cc-type2-(taid)5", "tags":[ - "de novo peptide", - "designed peptide", - "de novo protein", "coiled coil", + "de novo protein", "alpha-helical barrel", + "designed peptide", + "de novo peptide", "designed protein" ], "keywords":[ - "confirm", - "channels", - "must", - "use", - "imaging", - "electrical", - "crystallography", - "peptide", - "designed", - "perform", - "towards", + "membranes", + "hydrophobic", "show", + "simultaneously", + "fluorescent", + "lipid", "next", - "sequences", - "interactions", - "packed", + "novo", + "perform", + "confirm", + "channel", + "modify", + "helices", + "using", + "monodisperse", "lumens", - "unitary", - "structure", - "however", "alternative", - "phase", - "like", - "lipidic", - "interfaces", - "interiors", - "solved", - "specifically", - "de", "reconcile", - "compare", - "recordings", - "assemble", - "structures", + "however", "bilayers", + "polar", + "phase", "tightly", - "transmembrane", - "cubic", - "form", - "first", - "simultaneously", + "approach", + "recordings", + "use", + "interiors", + "electrical", + "like", "facilitate", - "properties", - "fluorescent", - "functional", - "reveals", - "generate", + "computational", + "peptide", "surprisingly", - "challenging", + "unitary", "design", - "lipid", - "using", - "states", - "hydrophobic", + "challenging", + "packed", + "must", + "functional", + "possible", + "different", + "compare", + "properties", "insertion", - "ion", - "one", - "membranes", - "conductance", - "observations", + "states", + "channels", + "solved", + "reveals", + "peptides", "analyses", - "helices", - "monodisperse", - "approach", - "barrels", - "novo", + "designed", + "form", + "conductance", + "sequences", + "interfaces", + "one", + "transmembrane", + "structures", + "de", "rational", - "channel", - "peptides", - "different", - "problem", + "take", + "first", + "imaging", + "lipidic", + "specifically", + "structure", + "generate", + "crystallography", + "interactions", + "ion", "state", "constricted", - "modify", - "polar", - "computational", - "take", - "possible" + "towards", + "cubic", + "problem", + "assemble", + "observations", + "barrels" ], "release_date":"2021-04-07", "publication":"\"Constructing ion channels from water-soluble alpha-helical barrels\", Nat.Chem., 13, 643-650", @@ -388907,92 +390437,92 @@ ], "subtitle":"Crystal structure of a parallel hexameric coiled coil cc-type2-(tasd)2", "tags":[ - "de novo peptide", - "designed peptide", - "de novo protein", "coiled coil", + "de novo protein", "alpha-helical barrel", + "designed peptide", + "de novo peptide", "designed protein" ], "keywords":[ - "confirm", - "channels", - "must", - "use", - "imaging", - "electrical", - "crystallography", - "peptide", - "designed", - "perform", - "towards", + "membranes", + "hydrophobic", "show", + "simultaneously", + "fluorescent", + "lipid", "next", - "sequences", - "interactions", - "packed", + "novo", + "perform", + "confirm", + "channel", + "modify", + "helices", + "using", + "monodisperse", "lumens", - "unitary", - "structure", - "however", "alternative", - "phase", - "like", - "lipidic", - "interfaces", - "interiors", - "solved", - "specifically", - "de", "reconcile", - "compare", - "recordings", - "assemble", - "structures", + "however", "bilayers", + "polar", + "phase", "tightly", - "transmembrane", - "cubic", - "form", - "first", - "simultaneously", + "approach", + "recordings", + "use", + "interiors", + "electrical", + "like", "facilitate", - "properties", - "fluorescent", - "functional", - "reveals", - "generate", + "computational", + "peptide", "surprisingly", - "challenging", + "unitary", "design", - "lipid", - "using", - "states", - "hydrophobic", + "challenging", + "packed", + "must", + "functional", + "possible", + "different", + "compare", + "properties", "insertion", - "ion", - "one", - "membranes", - "conductance", - "observations", + "states", + "channels", + "solved", + "reveals", + "peptides", "analyses", - "helices", - "monodisperse", - "approach", - "barrels", - "novo", + "designed", + "form", + "conductance", + "sequences", + "interfaces", + "one", + "transmembrane", + "structures", + "de", "rational", - "channel", - "peptides", - "different", - "problem", + "take", + "first", + "imaging", + "lipidic", + "specifically", + "structure", + "generate", + "crystallography", + "interactions", + "ion", "state", "constricted", - "modify", - "polar", - "computational", - "take", - "possible" + "towards", + "cubic", + "problem", + "assemble", + "observations", + "barrels" ], "release_date":"2021-04-07", "publication":"\"Constructing ion channels from water-soluble alpha-helical barrels\", Nat.Chem., 13, 643-650", @@ -389147,90 +390677,90 @@ ], "subtitle":"Crystal structure of an antiparallel octameric transmembrane coiled coil k2-cctm-vbic", "tags":[ - "de novo membrane protein", "de novo protein", "coiled coil", - "antiparallel coiled coil" + "antiparallel coiled coil", + "de novo membrane protein" ], "keywords":[ - "confirm", - "channels", - "must", - "use", - "imaging", - "electrical", - "crystallography", - "peptide", - "designed", - "perform", - "towards", + "membranes", + "hydrophobic", "show", + "simultaneously", + "fluorescent", + "lipid", "next", - "sequences", - "interactions", - "packed", + "novo", + "perform", + "confirm", + "channel", + "modify", + "helices", + "using", + "monodisperse", "lumens", - "unitary", - "structure", - "however", "alternative", - "phase", - "like", - "lipidic", - "interfaces", - "interiors", - "solved", - "specifically", - "de", "reconcile", - "compare", - "recordings", - "assemble", - "structures", + "however", "bilayers", + "polar", + "phase", "tightly", - "transmembrane", - "cubic", - "form", - "first", - "simultaneously", + "approach", + "recordings", + "use", + "interiors", + "electrical", + "like", "facilitate", - "properties", - "fluorescent", - "functional", - "reveals", - "generate", + "computational", + "peptide", "surprisingly", - "challenging", + "unitary", "design", - "lipid", - "using", - "states", - "hydrophobic", + "challenging", + "packed", + "must", + "functional", + "possible", + "different", + "compare", + "properties", "insertion", - "ion", - "one", - "membranes", - "conductance", - "observations", + "states", + "channels", + "solved", + "reveals", + "peptides", "analyses", - "helices", - "monodisperse", - "approach", - "barrels", - "novo", + "designed", + "form", + "conductance", + "sequences", + "interfaces", + "one", + "transmembrane", + "structures", + "de", "rational", - "channel", - "peptides", - "different", - "problem", + "take", + "first", + "imaging", + "lipidic", + "specifically", + "structure", + "generate", + "crystallography", + "interactions", + "ion", "state", "constricted", - "modify", - "polar", - "computational", - "take", - "possible" + "towards", + "cubic", + "problem", + "assemble", + "observations", + "barrels" ], "release_date":"2021-04-07", "publication":"\"Constructing ion channels from water-soluble alpha-helical barrels\", Nat.Chem., 13, 643-650", @@ -389381,92 +390911,92 @@ ], "subtitle":"Crystal structure of a parallel hexameric coiled coil cc-type2-(taid)2", "tags":[ - "de novo peptide", - "designed peptide", - "de novo protein", "coiled coil", + "de novo protein", "alpha-helical barrel", + "designed peptide", + "de novo peptide", "designed protein" ], "keywords":[ - "confirm", - "channels", - "must", - "use", - "imaging", - "electrical", - "crystallography", - "peptide", - "designed", - "perform", - "towards", + "membranes", + "hydrophobic", "show", + "simultaneously", + "fluorescent", + "lipid", "next", - "sequences", - "interactions", - "packed", + "novo", + "perform", + "confirm", + "channel", + "modify", + "helices", + "using", + "monodisperse", "lumens", - "unitary", - "structure", - "however", "alternative", - "phase", - "like", - "lipidic", - "interfaces", - "interiors", - "solved", - "specifically", - "de", "reconcile", - "compare", - "recordings", - "assemble", - "structures", + "however", "bilayers", + "polar", + "phase", "tightly", - "transmembrane", - "cubic", - "form", - "first", - "simultaneously", + "approach", + "recordings", + "use", + "interiors", + "electrical", + "like", "facilitate", - "properties", - "fluorescent", - "functional", - "reveals", - "generate", + "computational", + "peptide", "surprisingly", - "challenging", + "unitary", "design", - "lipid", - "using", - "states", - "hydrophobic", + "challenging", + "packed", + "must", + "functional", + "possible", + "different", + "compare", + "properties", "insertion", - "ion", - "one", - "membranes", - "conductance", - "observations", + "states", + "channels", + "solved", + "reveals", + "peptides", "analyses", - "helices", - "monodisperse", - "approach", - "barrels", - "novo", + "designed", + "form", + "conductance", + "sequences", + "interfaces", + "one", + "transmembrane", + "structures", + "de", "rational", - "channel", - "peptides", - "different", - "problem", + "take", + "first", + "imaging", + "lipidic", + "specifically", + "structure", + "generate", + "crystallography", + "interactions", + "ion", "state", "constricted", - "modify", - "polar", - "computational", - "take", - "possible" + "towards", + "cubic", + "problem", + "assemble", + "observations", + "barrels" ], "release_date":"2021-04-07", "publication":"\"Constructing ion channels from water-soluble alpha-helical barrels\", Nat.Chem., 13, 643-650", @@ -389780,81 +391310,81 @@ ], "subtitle":"Structure of the engineered metallo-diels-alderase da7 w16g,k58q,l77r,t78r", "tags":[ - "de novo diels-alderase", - "de novo protein" + "de novo protein", + "de novo diels-alderase" ], "keywords":[ - "sites", - "laboratory", - "directions", - "control", - "exciting", - "evolution", - "per", - "capitalize", - "unknown", - "proteins", - "pathway", - "repurposing", - "chemical", - "common", - "approach", - "exerts", - "catalysts", - "strategy", - "de", - "catalytic", - "metal", - "characterized", - "ions", - "novo", - "product", - "displays", - "directed", - "artificial", - "ts", - "enzyme", - "acid", - "properties", - "accelerating", - "4", - "absolute", - "stereochemistry", - "engineered", - "10", - "reactions", - "used", - "highly", - "active", + "turnovers", "reaction", - "may", + "ts", + "effective", + "directed", "propel", - "achieves", - "turnovers", - "abiological", + "engineered", + "design", + "transform", "metalloenzyme", - "nature", - "extension", - "far", - "proficiency", + "characterized", + "catalysis", + "metal", "show", - "design", - "naive", - "previously", - "effective", - "protein", + "extension", + "active", + "reactions", + "used", + "de", "natural", - "transform", - "exceeds", - "lewis", - "usually", - "scaffolds", "functionally", + "field", + "previously", + "properties", + "acid", + "scaffolds", "catalyst", - "catalysis", + "new", + "strategy", + "usually", + "displays", + "control", + "protein", + "nature", + "naive", + "approach", + "product", + "4", + "sites", + "proteins", + "stereochemistry", + "accelerating", + "artificial", + "ions", "site", - "field", - "new" + "proficiency", + "novo", + "may", + "far", + "pathway", + "enzyme", + "highly", + "abiological", + "common", + "absolute", + "laboratory", + "exciting", + "directions", + "catalytic", + "evolution", + "exerts", + "chemical", + "achieves", + "10", + "lewis", + "repurposing", + "capitalize", + "unknown", + "exceeds", + "per", + "catalysts" ], "release_date":"2021-04-28", "publication":"\"Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold\", Nat.Chem., 13, 231-235", @@ -389899,19 +391429,19 @@ }, { "sim":78.0, - "partner":"3v1d" + "partner":"3v1c" }, { "sim":78.0, - "partner":"3v1c" + "partner":"3v1d" }, { "sim":78.0, - "partner":"3v1b" + "partner":"3v1a" }, { "sim":78.0, - "partner":"3v1a" + "partner":"3v1b" }, { "sim":77.0, @@ -390034,109 +391564,109 @@ ], "subtitle":"Crystal structure of denovotim13, a de novo designed tim barrel", "tags":[ - "de novo protein design", - "stability landscape", "epistasis", + "de novo protein design", "de novo protein", - "(beta\/alfa)8 barrel", - "tim barrel" + "tim barrel", + "stability landscape", + "(beta\/alfa)8 barrel" ], "keywords":[ - "work", + "22", + "molecular", + "manipulating", + "hydrophobic", + "information", + "practical", "society", - "analysis", - "epistatic", + "thorough", + "folding", + "degrees", + "protein", + "study", + "relevance", + "novo", + "throughout", + "major", + "applications", + "related", + "region", + "stable", + "effects", + "using", + "goal", + "conformational", + "denovotims", "stabilizing", - "combined", - "scaffolds", - "designed", + "step", + "crucial", "uncharted", - "provide", - "mutations", - "throughout", - "towards", - "improved", - "22", - "based", + "functions", "basis", - "regions", - "8", - "expand", - "structure", - "crucial", - "modulation", + "stability", + "approach", + "combined", "proteins", - "de", + "packing", + "modular", "modulate", - "goal", - "step", - "ability", - "mol", - "kcal", - "natural", - "effects", - "first", - "thorough", - "previously", - "stability", - "per", - "molecular", + "subjected", + "since", + "barrel", + "computational", + "regions", + "design", + "work", "functional", + "natural", + "kcal", + "environment", + "different", + "fold", + "collection", + "mol", + "improved", + "biochemistry", + "validated", + "ability", "common", - "temperature", - "information", - "manipulating", - "stim11", - "functions", + "expand", "landscape", - "region", + "per", + "designed", + "analysis", + "determinants", + "one", + "mutations", + "extension", "observed", - "design", - "biochemistry", + "de", + "first", + "previously", + "epistasis", + "based", + "structure", + "stim11", + "important", + "scaffolds", + "provide", + "modulation", + "temperature", "spanning", - "60", + "understanding", "melting", - "denovotims", - "using", - "applications", - "hydrophobic", - "variations", - "packing", - "relevance", - "collection", - "important", + "navigate", + "epistatic", + "towards", + "appears", + "60", "tim", + "cores", "designs", - "one", - "conformational", - "approach", + "variations", + "8", "barrels", - "study", - "stable", - "novo", - "barrel", - "fold", - "appears", - "modular", - "epistasis", - "navigate", - "different", - "extension", - "validated", - "determinants", - "significant", - "cores", - "protein", - "degrees", - "environment", - "understanding", - "computational", - "subjected", - "practical", - "major", - "folding", - "since", - "related" + "significant" ], "release_date":"2021-07-21", "publication":"\"The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach\", J.Mol.Biol., 433, 167153-167153", @@ -390197,11 +391727,11 @@ }, { "sim":268.0, - "partner":"7ot7" + "partner":"7osu" }, { "sim":268.0, - "partner":"7osu" + "partner":"7ot7" }, { "sim":258.0, @@ -390337,109 +391867,109 @@ ], "subtitle":"Crystal structure of stim11nocys, a de novo designed tim barrel", "tags":[ - "de novo protein design", - "stability landscape", "epistasis", + "de novo protein design", "de novo protein", - "(beta\/alfa)8 barrel", - "tim barrel" + "tim barrel", + "stability landscape", + "(beta\/alfa)8 barrel" ], "keywords":[ - "work", + "22", + "molecular", + "manipulating", + "hydrophobic", + "information", + "practical", "society", - "analysis", - "epistatic", + "thorough", + "folding", + "degrees", + "protein", + "study", + "relevance", + "novo", + "throughout", + "major", + "applications", + "related", + "region", + "stable", + "effects", + "using", + "goal", + "conformational", + "denovotims", "stabilizing", - "combined", - "scaffolds", - "designed", + "step", + "crucial", "uncharted", - "provide", - "mutations", - "throughout", - "towards", - "improved", - "22", - "based", + "functions", "basis", - "regions", - "8", - "expand", - "structure", - "crucial", - "modulation", + "stability", + "approach", + "combined", "proteins", - "de", + "packing", + "modular", "modulate", - "goal", - "step", - "ability", - "mol", - "kcal", - "natural", - "effects", - "first", - "thorough", - "previously", - "stability", - "per", - "molecular", + "subjected", + "since", + "barrel", + "computational", + "regions", + "design", + "work", "functional", + "natural", + "kcal", + "environment", + "different", + "fold", + "collection", + "mol", + "improved", + "biochemistry", + "validated", + "ability", "common", - "temperature", - "information", - "manipulating", - "stim11", - "functions", + "expand", "landscape", - "region", + "per", + "designed", + "analysis", + "determinants", + "one", + "mutations", + "extension", "observed", - "design", - "biochemistry", + "de", + "first", + "previously", + "epistasis", + "based", + "structure", + "stim11", + "important", + "scaffolds", + "provide", + "modulation", + "temperature", "spanning", - "60", + "understanding", "melting", - "denovotims", - "using", - "applications", - "hydrophobic", - "variations", - "packing", - "relevance", - "collection", - "important", + "navigate", + "epistatic", + "towards", + "appears", + "60", "tim", + "cores", "designs", - "one", - "conformational", - "approach", + "variations", + "8", "barrels", - "study", - "stable", - "novo", - "barrel", - "fold", - "appears", - "modular", - "epistasis", - "navigate", - "different", - "extension", - "validated", - "determinants", - "significant", - "cores", - "protein", - "degrees", - "environment", - "understanding", - "computational", - "subjected", - "practical", - "major", - "folding", - "since", - "related" + "significant" ], "release_date":"2021-07-21", "publication":"\"The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach\", J.Mol.Biol., 433, 167153-167153", @@ -390476,11 +392006,11 @@ }, { "sim":402.0, - "partner":"7ot7" + "partner":"7osu" }, { "sim":402.0, - "partner":"7osu" + "partner":"7ot7" }, { "sim":392.0, @@ -390663,80 +392193,80 @@ ], "subtitle":"De novo designed protein 4e1h_95 in complex with 101f antibody", "tags":[ - "de novo designed protein", - "de novo protein" + "de novo protein", + "de novo designed protein" ], "keywords":[ - "accuracy", - "sites", + "difficulty", + "monitor", + "complex", + "demonstrates", + "elaborate", "responses", - "work", - "designs", + "engineered", + "mammalian", + "design", + "challenging", + "proved", + "however", + "signaling", + "structural", "molecular", - "part", - "functional", - "transplanting", - "proteins", - "build", - "available", - "tailored", - "orthogonal", + "recognition", "receptors", - "components", - "endow", - "approach", + "catalysis", + "tailored", + "work", + "accommodate", + "structurally", + "structures", + "creation", "de", - "novo", - "strategy", - "biochemical", - "antibody", - "modulate", - "four", - "bifunctionalized", - "signaling", - "including", - "challenging", - "successfully", - "engineered", - "confirmed", + "functional", + "due", "used", "approaches", - "demonstrates", - "functions", - "recognition", - "two", - "due", - "folds", - "crystal", + "endow", "potential", - "design", + "enabled", "biosensors", - "creation", - "structures", - "protein", "synthetic", - "mammalian", - "complex", - "elaborate", + "ligands", + "new", + "strategy", + "functions", + "protein", + "successfully", + "build", + "orthogonal", + "biochemical", + "approach", + "proteins", + "sites", + "part", + "binding", + "bifunctionalized", + "accuracy", "essential", - "proved", - "structurally", - "monitor", - "difficulty", - "motifs", + "confirmed", + "novo", + "modulate", + "cells", + "applied", "distinct", + "available", + "components", + "motifs", + "two", + "crystal", + "four", + "designs", "computational", - "applied", - "ligands", - "enabled", - "however", - "accommodate", - "cells", - "catalysis", - "binding", - "structural", - "five", - "new" + "folds", + "including", + "transplanting", + "antibody", + "five" ], "release_date":"2020-10-07", "publication":"\"Bottom-up de novo design of functional proteins with complex structural features\", Nat.Chem.Biol., 17, 492-500", @@ -390896,80 +392426,80 @@ ], "subtitle":"De novo designed protein 4h_01 in complex with mota antibody", "tags":[ - "de novo designed protein", - "de novo protein" + "de novo protein", + "de novo designed protein" ], "keywords":[ - "accuracy", - "sites", + "difficulty", + "monitor", + "complex", + "demonstrates", + "elaborate", "responses", - "work", - "designs", + "engineered", + "mammalian", + "design", + "challenging", + "proved", + "however", + "signaling", + "structural", "molecular", - "part", - "functional", - "transplanting", - "proteins", - "build", - "available", - "tailored", - "orthogonal", + "recognition", "receptors", - "components", - "endow", - "approach", + "catalysis", + "tailored", + "work", + "accommodate", + "structurally", + "structures", + "creation", "de", - "novo", - "strategy", - "biochemical", - "antibody", - "modulate", - "four", - "bifunctionalized", - "signaling", - "including", - "challenging", - "successfully", - "engineered", - "confirmed", + "functional", + "due", "used", "approaches", - "demonstrates", - "functions", - "recognition", - "two", - "due", - "folds", - "crystal", + "endow", "potential", - "design", + "enabled", "biosensors", - "creation", - "structures", - "protein", "synthetic", - "mammalian", - "complex", - "elaborate", + "ligands", + "new", + "strategy", + "functions", + "protein", + "successfully", + "build", + "orthogonal", + "biochemical", + "approach", + "proteins", + "sites", + "part", + "binding", + "bifunctionalized", + "accuracy", "essential", - "proved", - "structurally", - "monitor", - "difficulty", - "motifs", + "confirmed", + "novo", + "modulate", + "cells", + "applied", "distinct", + "available", + "components", + "motifs", + "two", + "crystal", + "four", + "designs", "computational", - "applied", - "ligands", - "enabled", - "however", - "accommodate", - "cells", - "catalysis", - "binding", - "structural", - "five", - "new" + "folds", + "including", + "transplanting", + "antibody", + "five" ], "release_date":"2020-10-07", "publication":"\"Bottom-up de novo design of functional proteins with complex structural features\", Nat.Chem.Biol., 17, 492-500", @@ -391099,131 +392629,131 @@ ], "subtitle":"Het-n2 - de novo designed three-helix heterodimer with cysteine at the n2 position of the alpha-helix", "tags":[ - "acyl transfer activity", "de novo protein", + "acyl transfer activity", "oxyanion-binding site", "domain swapped dimer" ], "keywords":[ - "results", - "critically", - "influences", - "catalysts", - "conjugation", - "acid", - "including", - "peptide", - "designed", - "prediction", - "robust", - "contains", - "principal", - "based", - "completion", - "position", - "\u03b1", - "represent", - "minimal", - "recently", - "oxidoreductases", - "applied", - "building", - "catalysis", - "starting", - "develop", - "junction", - "possesses", - "amide", - "proteins", - "unpaired", - "amidation", - "donors", - "de", - "enzymes", - "elements", - "minimalist", "negatively", - "point", - "efficient", - "goal", + "proved", + "stringent", + "structural", + "development", "number", - "small", - "motif", - "step", - "nucleophilic", "cavity", "project", - "charged", - "proved", - "showed", - "intermediates", - "first", - "second", - "thiol", - "outcome", - "reported", - "predefined", - "demonstrated", - "stringent", - "functional", - "amino", - "hydrolysis", + "donors", + "completion", + "rationally", + "hole", "group", + "acid", + "within", + "elements", + "results", + "residue", + "protein", + "restrictions", + "hydrolases", + "motif", + "showed", + "\u03b1", "acyl", - "report", - "others", + "charged", + "novo", + "site", "catalytic", - "artificial", + "oxyanion", + "adjacent", + "using", + "robust", + "chemistry", + "reaction", + "goal", + "conjugation", + "amidation", "reactions", - "restrictions", - "successful", + "starting", + "intermediates", + "step", + "influences", "specific", - "activity", - "transfer", - "concomitant", - "stabilize", - "introduced", - "design", - "nucleophile", - "rationally", - "bond", - "using", - "promising", - "exploited", - "formation", + "possesses", + "thiol", + "thioesters", + "oxidoreductases", "completely", - "structural", - "sites", - "hole", - "ligase", - "cysteine", - "chemistry", "approach", - "composition", - "novo", + "tetrahedral", + "proteins", + "sites", + "develop", + "unpaired", + "capable", + "concomitant", "acting", + "enzymes", + "contains", "labeling", - "sufficient", - "thioesters", + "small", + "bond", "emergence", - "momentum", - "reaction", - "capable", - "adjacent", - "hydrolases", - "gaining", - "set", - "protein", - "tetrahedral", - "residue", - "oxyanion", - "development", + "stabilize", + "introduced", "informatics", - "ligation", + "including", + "peptide", + "set", + "catalysts", + "design", + "critically", + "functional", + "represent", "environment", + "amide", + "ligation", + "cysteine", + "successful", + "prediction", + "point", + "gaining", + "amino", + "momentum", + "formation", + "promising", + "applied", + "building", + "reported", + "demonstrated", + "nucleophile", + "minimal", + "catalysis", + "designed", + "junction", + "ligase", + "efficient", + "others", + "de", + "principal", + "first", + "hydrolysis", + "based", + "predefined", + "report", + "recently", + "nucleophilic", + "artificial", "catalyzed", - "within", - "site" + "minimalist", + "activity", + "outcome", + "sufficient", + "composition", + "position", + "exploited", + "second", + "transfer" ], "release_date":"2021-03-17", "publication":"\"Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of alpha-Helix As Oxyanion-Binding Site\", J.Am.Chem.Soc., 143, 3330-3339", @@ -391359,131 +392889,131 @@ ], "subtitle":"Het-ncap - de novo designed three-helix heterodimer with cysteine at the ncap position of the alpha-helix", "tags":[ - "acyl transfer activity", "de novo protein", + "acyl transfer activity", "oxyanion-binding site", "domain swapped dimer" ], "keywords":[ - "results", - "critically", - "influences", - "catalysts", - "conjugation", - "acid", - "including", - "peptide", - "designed", - "prediction", - "robust", - "contains", - "principal", - "based", - "completion", - "position", - "\u03b1", - "represent", - "minimal", - "recently", - "oxidoreductases", - "applied", - "building", - "catalysis", - "starting", - "develop", - "junction", - "possesses", - "amide", - "proteins", - "unpaired", - "amidation", - "donors", - "de", - "enzymes", - "elements", - "minimalist", "negatively", - "point", - "efficient", - "goal", + "proved", + "stringent", + "structural", + "development", "number", - "small", - "motif", - "step", - "nucleophilic", "cavity", "project", - "charged", - "proved", - "showed", - "intermediates", - "first", - "second", - "thiol", - "outcome", - "reported", - "predefined", - "demonstrated", - "stringent", - "functional", - "amino", - "hydrolysis", + "donors", + "completion", + "rationally", + "hole", "group", + "acid", + "within", + "elements", + "results", + "residue", + "protein", + "restrictions", + "hydrolases", + "motif", + "showed", + "\u03b1", "acyl", - "report", - "others", + "charged", + "novo", + "site", "catalytic", - "artificial", + "oxyanion", + "adjacent", + "using", + "robust", + "chemistry", + "reaction", + "goal", + "conjugation", + "amidation", "reactions", - "restrictions", - "successful", + "starting", + "intermediates", + "step", + "influences", "specific", - "activity", - "transfer", - "concomitant", - "stabilize", - "introduced", - "design", - "nucleophile", - "rationally", - "bond", - "using", - "promising", - "exploited", - "formation", + "possesses", + "thiol", + "thioesters", + "oxidoreductases", "completely", - "structural", - "sites", - "hole", - "ligase", - "cysteine", - "chemistry", "approach", - "composition", - "novo", + "tetrahedral", + "proteins", + "sites", + "develop", + "unpaired", + "capable", + "concomitant", "acting", + "enzymes", + "contains", "labeling", - "sufficient", - "thioesters", + "small", + "bond", "emergence", - "momentum", - "reaction", - "capable", - "adjacent", - "hydrolases", - "gaining", - "set", - "protein", - "tetrahedral", - "residue", - "oxyanion", - "development", + "stabilize", + "introduced", "informatics", - "ligation", + "including", + "peptide", + "set", + "catalysts", + "design", + "critically", + "functional", + "represent", "environment", + "amide", + "ligation", + "cysteine", + "successful", + "prediction", + "point", + "gaining", + "amino", + "momentum", + "formation", + "promising", + "applied", + "building", + "reported", + "demonstrated", + "nucleophile", + "minimal", + "catalysis", + "designed", + "junction", + "ligase", + "efficient", + "others", + "de", + "principal", + "first", + "hydrolysis", + "based", + "predefined", + "report", + "recently", + "nucleophilic", + "artificial", "catalyzed", - "within", - "site" + "minimalist", + "activity", + "outcome", + "sufficient", + "composition", + "position", + "exploited", + "second", + "transfer" ], "release_date":"2021-03-17", "publication":"\"Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of alpha-Helix As Oxyanion-Binding Site\", J.Am.Chem.Soc., 143, 3330-3339", @@ -391516,11 +393046,11 @@ "seq_thr_sim_designed":[ { "sim":87.0, - "partner":"6z0l" + "partner":"7bey" }, { "sim":87.0, - "partner":"7bey" + "partner":"6z0l" } ], "seq_thr_sim_natural":[ @@ -391537,7 +393067,7 @@ ], "seq_max_sim_designed":{ "sim":87.0, - "partner":"6z0l" + "partner":"7bey" }, "seq_max_sim_natural":[ @@ -391627,109 +393157,109 @@ ], "subtitle":"Crystal structure of denovotim6, a de novo designed tim barrel", "tags":[ - "de novo protein design", - "stability landscape", "epistasis", + "de novo protein design", "de novo protein", - "(beta\/alfa)8 barrel", - "tim barrel" + "tim barrel", + "stability landscape", + "(beta\/alfa)8 barrel" ], "keywords":[ - "work", + "22", + "molecular", + "manipulating", + "hydrophobic", + "information", + "practical", "society", - "analysis", - "epistatic", + "thorough", + "folding", + "degrees", + "protein", + "study", + "relevance", + "novo", + "throughout", + "major", + "applications", + "related", + "region", + "stable", + "effects", + "using", + "goal", + "conformational", + "denovotims", "stabilizing", - "combined", - "scaffolds", - "designed", + "step", + "crucial", "uncharted", - "provide", - "mutations", - "throughout", - "towards", - "improved", - "22", - "based", + "functions", "basis", - "regions", - "8", - "expand", - "structure", - "crucial", - "modulation", + "stability", + "approach", + "combined", "proteins", - "de", + "packing", + "modular", "modulate", - "goal", - "step", - "ability", - "mol", - "kcal", - "natural", - "effects", - "first", - "thorough", - "previously", - "stability", - "per", - "molecular", + "subjected", + "since", + "barrel", + "computational", + "regions", + "design", + "work", "functional", + "natural", + "kcal", + "environment", + "different", + "fold", + "collection", + "mol", + "improved", + "biochemistry", + "validated", + "ability", "common", - "temperature", - "information", - "manipulating", - "stim11", - "functions", + "expand", "landscape", - "region", + "per", + "designed", + "analysis", + "determinants", + "one", + "mutations", + "extension", "observed", - "design", - "biochemistry", + "de", + "first", + "previously", + "epistasis", + "based", + "structure", + "stim11", + "important", + "scaffolds", + "provide", + "modulation", + "temperature", "spanning", - "60", + "understanding", "melting", - "denovotims", - "using", - "applications", - "hydrophobic", - "variations", - "packing", - "relevance", - "collection", - "important", + "navigate", + "epistatic", + "towards", + "appears", + "60", "tim", + "cores", "designs", - "one", - "conformational", - "approach", + "variations", + "8", "barrels", - "study", - "stable", - "novo", - "barrel", - "fold", - "appears", - "modular", - "epistasis", - "navigate", - "different", - "extension", - "validated", - "determinants", - "significant", - "cores", - "protein", - "degrees", - "environment", - "understanding", - "computational", - "subjected", - "practical", - "major", - "folding", - "since", - "related" + "significant" ], "release_date":"2021-07-21", "publication":"\"The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach\", J.Mol.Biol., 433, 167153-167153", @@ -391782,11 +393312,11 @@ }, { "sim":334.0, - "partner":"7ot7" + "partner":"7osu" }, { "sim":334.0, - "partner":"7osu" + "partner":"7ot7" }, { "sim":325.0, @@ -391918,81 +393448,81 @@ "protein" ], "keywords":[ - "stability", - "combining", - "harsh", - "unfolding", - "molecular", - "functional", - "build", - "proteins", - "conditions", - "extreme", - "conformational", - "chemical", - "process", + "surface", + "central", "desolvation", - "experiments", - "amphiphilic", - "artificial", "directed", - "point", - "temperatures", + "often", + "molecular", + "surroundings", + "design", + "conformational", + "hydrophobic", + "structural", + "atomic", + "packed", + "show", + "principles", + "mutations", + "soluble", + "shield", + "structures", + "natural", + "resistant", "resolving", - "illustrate", - "gain", - "may", - "residues", - "indispensable", - "landscape", + "functional", "yet", - "universally", - "electrostatically", - "perturbation", + "core", + "combining", + "biological", + "effect", "rearrangements", - "motif", - "towards", + "residues", + "within", + "introduce", "provide", - "mutations", - "often", "polar", - "central", - "surroundings", - "show", + "experiments", + "folding", + "extreme", + "harsh", + "findings", + "point", "drive", + "universally", "explore", - "core", - "design", - "findings", - "alter", - "structures", "protein", - "soluble", "buried", - "packed", - "shield", - "hydrophobic", - "introduce", - "charged", - "natural", - "effect", - "surface", - "validate", - "atomic", + "biophysical", + "build", "function", - "resistant", - "stabilised", + "stability", + "illustrate", + "validate", + "understanding", + "proteins", + "process", + "artificial", + "motif", + "unfolding", + "conditions", + "gain", "networks", - "biological", + "charged", + "towards", + "may", + "stabilised", + "alter", + "electrostatically", + "landscape", + "amphiphilic", + "chemical", + "indispensable", + "effects", "physical", - "within", + "temperatures", + "perturbation", "computational", - "effects", - "understanding", - "principles", - "folding", - "structural", - "biophysical", "compensate" ], "release_date":"2021-04-07", @@ -392121,83 +393651,83 @@ ], "subtitle":"Two states of a de novo hexameric coiled coil assembly cc-type2-(laidge)4", "tags":[ - "de novo peptide", - "multi-state", "de novo protein", - "coiled coil" + "coiled coil", + "multi-state", + "de novo peptide" ], "keywords":[ - "interfaces", - "placing", - "designs", - "advancing", - "amphipathic", - "delivered", - "molecular", - "maintain", + "designed", + "form", + "open", "judiciously", - "accessible", - "multiple", - "conditions", - "helices", + "simulations", + "interconverting", + "molecular", + "design", "steric", - "drives", - "report", + "however", + "hydrophobic", + "functionalisable", + "cavities", + "interfaces", + "indicate", + "indeed", + "glycine", + "structures", "de", - "novo", "single", "rational", - "barrels", - "barrel", - "suggest", - "interconvertible", - "rapidly", - "peptide", - "indeed", - "designed", - "glycine", - "together", - "open", - "switch", - "landscape", - "simulations", - "functionalisable", - "interconverting", + "associate", + "multiple", "experimentally", - "crystal", - "system", - "complete", + "placing", + "effect", + "accessible", + "rapidly", "addition", - "obtain", - "design", - "dynamics", + "report", + "within", + "usually", + "consolidated", "findings", - "helical", - "structures", + "interactions", "protein", + "complete", + "bind", + "helical", + "silico", + "delivered", + "barrels", "\u03b1", - "cores", - "interactions", + "conditions", + "drives", + "together", + "novo", + "dynamics", + "maintain", "states", - "hydrophobic", + "system", + "suggest", + "forms", + "cores", + "landscape", + "switch", + "affects", + "recent", "frustrated", - "effect", + "compact", + "crystal", + "helices", + "designs", + "amphipathic", + "barrel", "collapse", - "bind", - "consolidated", - "recent", - "cavities", - "indicate", - "within", "computational", - "affects", - "form", - "silico", - "usually", - "however", - "forms", - "associate", - "compact" + "interconvertible", + "peptide", + "advancing", + "obtain" ], "release_date":"2021-02-03", "publication":"\"Structural resolution of switchable states of a de novo peptide assembly\", Nat Commun, 12, 1530-1530", @@ -392234,10 +393764,6 @@ ], "struct_thr_sim_designed":[ - { - "sim":1.0, - "partner":"6xy1" - }, { "sim":1.0, "partner":"4pna" @@ -392247,24 +393773,28 @@ "partner":"5ez8" }, { - "sim":1.0, - "partner":"7nff" + "sim":0.9984999895, + "partner":"7nfj" }, { - "sim":0.9972000122, - "partner":"7nfi" + "sim":0.9983999729, + "partner":"7nfk" }, { - "sim":0.9984999895, - "partner":"7nfj" + "sim":0.9986000061, + "partner":"7bas" }, { - "sim":0.9984999895, - "partner":"7nfl" + "sim":1.0, + "partner":"5ez9" }, { "sim":1.0, - "partner":"7nfm" + "partner":"6eik" + }, + { + "sim":0.9984999895, + "partner":"7nfl" }, { "sim":0.993900001, @@ -392272,123 +393802,127 @@ }, { "sim":1.0, - "partner":"7nfg" + "partner":"6g6f" }, { - "sim":0.9987000227, - "partner":"7nfp" + "sim":1.0, + "partner":"7nfn" }, { - "sim":0.9983999729, - "partner":"7nfk" + "sim":1.0, + "partner":"6xy1" + }, + { + "sim":0.9975000024, + "partner":"4pn9" }, { "sim":1.0, - "partner":"6yb2" + "partner":"6eiz" }, { "sim":1.0, - "partner":"5ez9" + "partner":"5ezc" }, { "sim":1.0, "partner":"7bav" }, { - "sim":0.9986000061, - "partner":"7bas" + "sim":0.9954000115, + "partner":"8a09" }, { "sim":1.0, - "partner":"6eik" + "partner":"8b16" }, { - "sim":1.0, - "partner":"5eza" + "sim":0.9901000261, + "partner":"8b15" }, { - "sim":1.0, - "partner":"6g6f" + "sim":0.9926999807, + "partner":"6g6b" }, { - "sim":1.0, - "partner":"6g6g" + "sim":0.9983000159, + "partner":"7nfh" }, { - "sim":1.0, - "partner":"7nfn" + "sim":0.9607999921, + "partner":"5eze" }, { - "sim":0.9975000024, - "partner":"4pn9" + "sim":0.9923999906, + "partner":"6g6a" }, { "sim":1.0, - "partner":"6eiz" + "partner":"6g6g" }, { "sim":1.0, - "partner":"5ezc" + "partner":"7nff" }, { "sim":1.0, - "partner":"6xy0" + "partner":"7nfm" }, { - "sim":0.9983000159, - "partner":"7nfh" + "sim":1.0, + "partner":"7bo9" }, { - "sim":0.9769999981, - "partner":"6yaz" + "sim":1.0, + "partner":"7nfg" }, { - "sim":0.9973999858, - "partner":"6xxz" + "sim":0.9972000122, + "partner":"7nfi" }, { - "sim":1.0, - "partner":"8b16" + "sim":0.9987000227, + "partner":"7nfp" }, { "sim":0.9769999981, - "partner":"6yb0" + "partner":"6yaz" }, { - "sim":0.9954000115, - "partner":"8a09" + "sim":0.9769999981, + "partner":"6yb0" }, { - "sim":0.9901000261, - "partner":"8b15" + "sim":0.9937000275, + "partner":"7bau" }, { "sim":1.0, - "partner":"6g6c" + "partner":"6yb2" }, { "sim":1.0, - "partner":"7boa" + "partner":"5eza" }, { - "sim":1.0, - "partner":"4pn8" + "sim":0.9973999858, + "partner":"6xxz" }, { "sim":1.0, - "partner":"6g65" + "partner":"6xy0" }, { - "sim":0.9983999729, - "partner":"6g67" + "sim":0.9934999943, + "partner":"7a1t" }, { - "sim":0.9926999807, - "partner":"6g6b" + "sim":0.9925000072, + "partner":"7bim" }, { - "sim":0.9923999906, - "partner":"6g6a" + "sim":0.965200007, + "partner":"9gf2" }, { "sim":0.9984999895, @@ -392396,23 +393930,23 @@ }, { "sim":1.0, - "partner":"7bo9" + "partner":"6g6c" }, { - "sim":0.9607999921, - "partner":"5eze" + "sim":1.0, + "partner":"7boa" }, { - "sim":0.9937000275, - "partner":"7bau" + "sim":1.0, + "partner":"6g65" }, { - "sim":0.9934999943, - "partner":"7a1t" + "sim":0.9983999729, + "partner":"6g67" }, { - "sim":0.9925000072, - "partner":"7bim" + "sim":1.0, + "partner":"4pn8" }, { "sim":0.9958000183, @@ -392430,7 +393964,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"5ez8" + "partner":"6eik" }, "struct_max_sim_natural":[ @@ -392500,106 +394034,106 @@ ], "subtitle":"Terbium(iii)-bound de novo tim barrel-ferredoxin fold fusion dimer with 4-glutamate binding site and tryptophan antenna (tfd-ee n6w)", "tags":[ - "lanthanide-binding protein", - "de novo protein" + "de novo protein", + "lanthanide-binding protein" ], "keywords":[ - "axes", - "confirm", - "many", - "long", - "thus", - "close", - "ions", - "signaling", - "challenge", - "scaffolds", - "designed", - "installing", - "functionalized", - "cofactors", - "dimeric", - "crystal", - "lanthanide", - "axis", "affinity", - "alternative", - "chambers", - "generating", - "420", - "proteins", - "program", - "de", - "outstanding", + "substrates", + "defined", "luminescence", + "cavities", + "outstanding", "presence", - "top", - "remains", - "serve", - "difficult", - "binds", - "often", - "structures", - "natural", - "ferredoxin", - "pockets", - "cubic", - "form", - "molecules", - "platform", "bottom", - "substrates", - "demonstrated", - "loops", - "making", - "terbium", - "large", - "defined", "extended", + "aligned", + "cofactors", + "lanthanide", + "protein", "globular", - "four", + "pockets", + "binding", + "terbium", + "close", + "site", + "novo", + "two", + "confirm", + "variety", + "succeeded", + "crystal", + "stable", + "binds", "biocatalysts", - "fused", - "challenging", - "aligned", + "construction", + "reaction", + "alternative", + "program", + "420", + "top", "dimer", - "design", "metals", - "\u00e5ngstr\u00f6m", - "symmetry", - "describe", - "high", - "cavities", - "could", - "c2", - "tim", - "consisting", - "designs", - "construction", + "thus", + "residues", + "fused", + "axis", "approach", - "novo", - "stable", - "flexible", - "barrel", - "succeeded", - "fold", - "enzymatic", + "large", + "proteins", + "ions", + "chambers", "modular", - "residues", - "reaction", - "two", - "precisely", - "problem", - "glutamate", "scaffold", - "binding", - "protein", - "variety", + "axes", + "ferredoxin", + "four", + "barrel", + "long", + "c2", "computational", - "chamber", + "symmetry", + "design", + "challenging", + "signaling", "accommodate", - "site", - "create" + "loops", + "natural", + "consisting", + "platform", + "fold", + "\u00e5ngstr\u00f6m", + "precisely", + "chamber", + "demonstrated", + "generating", + "describe", + "could", + "designed", + "form", + "often", + "many", + "structures", + "de", + "remains", + "enzymatic", + "scaffolds", + "flexible", + "serve", + "installing", + "making", + "molecules", + "high", + "difficult", + "tim", + "glutamate", + "cubic", + "problem", + "challenge", + "create", + "designs", + "functionalized", + "dimeric" ], "release_date":"2020-11-25", "publication":"\"Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion\", Proc.Natl.Acad.Sci.USA, 117, 30362-30369", @@ -392704,11 +394238,11 @@ }, { "sim":93.0, - "partner":"7ot7" + "partner":"7osu" }, { "sim":93.0, - "partner":"7osu" + "partner":"7ot7" }, { "sim":93.0, @@ -392811,98 +394345,98 @@ ], "subtitle":"A collapsed hexameric state of a de novo coiled-coil assembly: cc-type2-(gglaid)4-w19brphe", "tags":[ + "homomeric assembly", "de novo protein", "coiled coil", - "homomeric assembly", "synthetic peptide" ], "keywords":[ - "amphipathic", - "oligomers", - "z", - "pentameric", - "must", - "discriminate", - "pattern", - "controllably", - "accessed", + "made", + "repeats", "allow", - "dimeric", - "smaller", - "crystal", - "target", + "hydrophobic", "show", - "sequences", + "glycine", "closer", - "however", - "alternative", - "expanding", - "contacts", - "direct", - "forces", - "interfaces", - "progressively", - "larger", - "unique", - "de", - "h", - "produce", + "pattern", + "side", + "accessed", + "short", + "residue", + "pentameric", "linear", - "nonetheless", - "point", - "hpphppp", + "helical", + "tetrameric", + "novo", + "controllably", + "hpphhph", + "crystal", + "predictably", + "weak", + "helices", + "chains", + "water", + "alternative", + "however", + "bundles", "decreasing", - "resulting", - "short", - "made", - "assemble", + "p", + "nonameric", + "residues", + "helix", "gives", - "structures", - "assembly", + "polar", + "progressively", + "contacts", + "sites", "size", - "alanine", - "predictably", - "considerable", - "directly", - "serine", - "assemblies", - "bundles", - "four", - "glycine", - "challenging", + "hpphppp", + "larger", + "nominally", + "threonine", "stabilize", + "four", + "serine", + "direct", "design", - "encode", - "avoid", - "helical", - "weak", + "challenging", + "must", + "discriminate", + "produce", + "assembly", + "alanine", + "point", + "forces", + "varying", + "rationalize", "states", - "hydrophobic", - "progress", "sequence", - "repeats", - "rationalize", - "threonine", - "tetrameric", - "sites", - "chains", + "peptides", + "encode", + "expanding", + "nonetheless", + "unique", + "assemblies", + "amphipathic", + "directly", + "h", + "z", + "sequences", "one", - "helices", - "barrels", - "novo", - "nonameric", + "interfaces", + "structures", + "de", "rational", - "peptides", - "nominally", - "residues", - "polar", - "hpphhph", - "residue", - "helix", - "water", - "varying", - "side", - "p" + "progress", + "oligomers", + "resulting", + "target", + "considerable", + "smaller", + "assemble", + "avoid", + "barrels", + "dimeric" ], "release_date":"2021-05-19", "publication":"\"Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states\", Chem Sci, 12, 6923-6928", @@ -392943,21 +394477,25 @@ "sim":1.0, "partner":"7bim" }, - { - "sim":0.9961000085, - "partner":"8a09" - }, { "sim":1.0, "partner":"7baw" }, + { + "sim":0.996900022, + "partner":"7bat" + }, { "sim":1.0, "partner":"7bas" }, { - "sim":0.996900022, - "partner":"7bat" + "sim":1.0, + "partner":"7bav" + }, + { + "sim":0.9961000085, + "partner":"8a09" }, { "sim":1.0, @@ -392967,81 +394505,85 @@ "sim":1.0, "partner":"6eiz" }, + { + "sim":1.0, + "partner":"8b16" + }, { "sim":0.9957000017, "partner":"8b15" }, { "sim":1.0, - "partner":"8b16" + "partner":"6xy1" }, { "sim":1.0, - "partner":"7bav" + "partner":"4pna" }, { "sim":1.0, - "partner":"4pna" + "partner":"7nff" }, { "sim":1.0, - "partner":"5ez8" + "partner":"7nfj" }, { - "sim":0.9980999827, - "partner":"7nfk" + "sim":1.0, + "partner":"5ez8" }, { "sim":1.0, - "partner":"7nfj" + "partner":"7nfg" }, { "sim":1.0, - "partner":"6xy1" + "partner":"7nfi" }, { "sim":1.0, - "partner":"5ez9" + "partner":"7nfl" }, { "sim":1.0, - "partner":"7bau" + "partner":"7nfm" }, { "sim":0.9955000281, "partner":"7nfo" }, { - "sim":0.9965999722, - "partner":"6eik" + "sim":1.0, + "partner":"7nfp" }, { - "sim":1.0, - "partner":"6g6f" + "sim":0.9980999827, + "partner":"7nfk" }, { "sim":1.0, - "partner":"7nfl" + "partner":"6yb2" }, { "sim":1.0, - "partner":"7nfn" + "partner":"5ez9" }, { "sim":1.0, - "partner":"5ezc" + "partner":"7bau" }, { - "sim":1.0, - "partner":"7nfh" + "sim":0.9965999722, + "partner":"6eik" }, { - "sim":0.9941999912, - "partner":"6g6b" + "sim":1.0, + "partner":"5eza" }, { - "sim":0.996900022, - "partner":"6g6a" + "sim":1.0, + "partner":"6g6f" }, { "sim":1.0, @@ -393049,7 +394591,7 @@ }, { "sim":1.0, - "partner":"7bo9" + "partner":"7nfn" }, { "sim":0.9983000159, @@ -393057,11 +394599,19 @@ }, { "sim":1.0, - "partner":"7nff" + "partner":"5ezc" }, { "sim":1.0, - "partner":"7nfm" + "partner":"6xxz" + }, + { + "sim":1.0, + "partner":"6xy0" + }, + { + "sim":1.0, + "partner":"7nfh" }, { "sim":0.9769999981, @@ -393073,35 +394623,27 @@ }, { "sim":1.0, - "partner":"7nfg" - }, - { - "sim":1.0, - "partner":"7nfi" + "partner":"6g6c" }, { "sim":1.0, - "partner":"7nfp" + "partner":"7boa" }, { - "sim":1.0, - "partner":"6yb2" + "sim":0.996900022, + "partner":"6g6a" }, { - "sim":1.0, - "partner":"5eza" + "sim":0.9941999912, + "partner":"6g6b" }, { - "sim":1.0, - "partner":"6xxz" + "sim":0.9987000227, + "partner":"6g65" }, { "sim":1.0, - "partner":"6xy0" - }, - { - "sim":0.9934999943, - "partner":"6zt1" + "partner":"6g67" }, { "sim":1.0, @@ -393109,31 +394651,23 @@ }, { "sim":1.0, - "partner":"7boa" + "partner":"7bo9" }, { - "sim":0.9970999956, - "partner":"6g69" + "sim":0.9952999949, + "partner":"6i1j" }, { - "sim":1.0, - "partner":"6g6c" + "sim":0.9934999943, + "partner":"6zt1" }, { - "sim":0.9987000227, - "partner":"6g65" + "sim":0.9970999956, + "partner":"6g69" }, { "sim":0.9941999912, "partner":"4dzk" - }, - { - "sim":1.0, - "partner":"6g67" - }, - { - "sim":0.9952999949, - "partner":"6i1j" } ], "struct_thr_sim_natural":[ @@ -393147,7 +394681,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"7baw" + "partner":"7bim" }, "struct_max_sim_natural":[ @@ -393193,90 +394727,90 @@ "subtitle":"De novo designed ba8-barrel stim11 with an alpha-helical extension", "tags":[ "de novo protein", - "stim11", "protein design", - "tim-barrel" + "tim-barrel", + "stim11" ], "keywords":[ - "opens", - "many", + "well", + "around", + "short", + "folding", + "model", + "protein", "biochemical", - "robust", - "provide", - "towards", - "potential", - "based", - "harbor", - "structure", - "minimal", - "building", - "novel", - "pipeline", - "like", - "aim", + "binding", + "novo", + "major", + "catalytic", + "recent", "adapt", - "topology", "entire", - "de", - "enzymes", - "compare", - "enzyme", - "less", + "focused", + "initio", + "robust", + "complex", "top", - "ab", - "short", - "diversify", - "symmetric", - "ability", - "attempts", - "construct", - "future", - "popular", - "size", - "solves", - "common", - "catalytic", "reactions", - "successful", - "provides", - "design", - "model", - "characterization", - "adding", - "recent", + "due", "opportunities", - "around", - "tim", - "variant", - "diverse", + "helix", + "pipeline", + "vicinity", + "popular", "sites", - "designs", - "one", - "novo", + "characterization", + "size", + "enzymes", + "scaffold", + "enzyme", + "future", + "construct", "barrel", + "like", + "computational", + "pocket", + "design", + "topology", + "diverse", + "provides", + "compare", + "potential", "fold", - "well", - "focused", - "vicinity", - "initio", - "understood", - "extension", - "due", - "arrangements", - "scaffold", + "variant", + "solves", "considered", + "successful", "explore", - "protein", - "complex", - "helix", + "symmetric", + "ab", + "understood", + "ability", + "building", + "common", + "developed", + "minimal", + "aim", + "many", + "one", + "extension", + "opens", + "de", + "diversify", + "attempts", + "based", + "structure", + "provide", "block", + "adding", + "harbor", + "towards", "extend", - "computational", - "major", - "folding", - "pocket", - "binding", - "developed" + "tim", + "arrangements", + "designs", + "less", + "novel" ], "release_date":"2021-03-24", "publication":"\"Extension of a de novo TIM barrel with a rationally designed secondary structure element\", Protein Sci., 30, 982-989", @@ -393317,11 +394851,11 @@ }, { "sim":387.0, - "partner":"7ot7" + "partner":"7osu" }, { "sim":387.0, - "partner":"7osu" + "partner":"7ot7" }, { "sim":329.0, @@ -393509,84 +395043,84 @@ "maquette" ], "keywords":[ - "nm", - "4d2", - "indicating", - "represents", - "utilized", - "use", - "untapped", - "illustrated", - "monoheme", - "validation", - "robust", - "cofactors", - "potential", - "structure", - "expressible", + "demonstrates", + "engineering", + "molecular", "redesign", - "thermostable", "7", - "detail", - "biomolecular", - "presents", - "de", - "electrostatic", - "kda", - "highly", - "demonstrates", + "continuum", + "thermostable", + "experimental", + "positioning", + "extended", + "heme", + "cofactors", + "protein", + "readily", + "helical", + "electron", + "weight", + "novo", + "exquisite", + "monoheme", + "secondary", "resource", + "robust", + "construction", "life", - "representing", - "future", + "expressible", + "nanoscale", + "diheme", + "represents", + "level", "designable", - "platform", - "created", - "properties", - "wire", - "valuable", - "molecular", + "representing", "remarkable", - "report", - "extended", - "calculations", - "tetraheme", - "artificial", + "valuable", + "characterization", + "use", + "modular", + "illustrated", + "highly", + "created", "maquette", - "circuitry", - "redox", - "exquisite", - "nanoscale", - "engineering", + "future", + "24", + "computational", "bundle", + "untapped", + "redox", "design", - "characterization", - "weight", - "helical", - "secondary", - "cryomicroscopy", - "predicted", + "expanded", + "electrostatic", + "potential", + "nm", + "platform", + "properties", + "indicating", "variant", - "despite", + "wire", + "biomolecular", + "utilized", + "kda", + "predicted", + "validation", "fundamental", - "construction", - "positioning", - "novo", - "experimental", - "heme", - "modular", - "electron", + "tetraheme", + "calculations", + "presents", + "de", + "cryomicroscopy", + "structure", + "report", "subsequently", - "24", - "protein", - "continuum", - "readily", - "computational", - "diheme", - "expanded", - "create", + "circuitry", "biophysical", - "level" + "detail", + "artificial", + "4d2", + "despite", + "create" ], "release_date":"2021-10-06", "publication":"\"An expandable, modular de novo protein platform for precision redox engineering\", Proc.Natl.Acad.Sci.USA, 120, e2306046120-e2306046120", @@ -393699,31 +395233,31 @@ "alpha\/beta-peptide" ], "keywords":[ - "built", + "conformation", + "dimers", + "revealed", "one", - "helices", + "hydrophobic", + "formed", + "built", "pattern", - "unprecedented", - "including", - "surfaces", - "miniprotein", - "dimers", - "crystal", - "new", - "based", "core", - "conformation", - "hydrophobic", - "\u03b1\u03b1\u03b2\u03b1\u03b1\u03b1\u03b2", - "structure", + "based", "three", + "structure", + "new", + "surfaces", + "interaction", + "\u03b1\u03b1\u03b2\u03b1\u03b1\u03b1\u03b2", "sequence", - "stabilized", - "revealed", "developed", - "formed", + "crystal", "compact", - "interaction" + "unprecedented", + "helices", + "miniprotein", + "stabilized", + "including" ], "release_date":"2021-07-14", "publication":"\"A computationally designed beta-amino acid-containing miniprotein\", Chem.Commun.(Camb.), 57, 6015-6018", @@ -393843,31 +395377,31 @@ "alpha\/beta-peptide" ], "keywords":[ - "built", + "conformation", + "dimers", + "revealed", "one", - "helices", + "hydrophobic", + "formed", + "built", "pattern", - "unprecedented", - "including", - "surfaces", - "miniprotein", - "dimers", - "crystal", - "new", - "based", "core", - "conformation", - "hydrophobic", - "\u03b1\u03b1\u03b2\u03b1\u03b1\u03b1\u03b2", - "structure", + "based", "three", + "structure", + "new", + "surfaces", + "interaction", + "\u03b1\u03b1\u03b2\u03b1\u03b1\u03b1\u03b2", "sequence", - "stabilized", - "revealed", "developed", - "formed", + "crystal", "compact", - "interaction" + "unprecedented", + "helices", + "miniprotein", + "stabilized", + "including" ], "release_date":"2021-07-14", "publication":"\"A computationally designed beta-amino acid-containing miniprotein\", Chem.Commun.(Camb.), 57, 6015-6018", @@ -393991,51 +395525,51 @@ "beta-propeller" ], "keywords":[ - "crystallization", + "made", + "designed", + "eightfold", + "conformation", + "design", + "revealed", + "adopt", + "however", "propeller", - "designs", - "years", "one", - "proteins", - "usefulness", - "named", - "crystallography", - "including", + "development", + "ones", "crystallized", - "designed", + "named", + "attempts", + "distorted", + "crystallization", + "structure", + "addition", "seen", - "engineer", - "two", - "eightfold", + "recently", + "crystallography", + "protein", + "proteins", "symmetric", + "cake", "leading", + "molecules", "highlighting", - "made", - "addition", - "design", - "additives", - "protein", "upon", - "attempts", - "using", - "adopt", - "conformation", - "termini", - "polyoxometalate", - "development", - "cake", + "years", + "additives", + "two", + "developed", "recent", - "structure", - "revealed", - "recently", - "increase", + "polyoxometalate", + "termini", + "designs", + "engineer", + "usefulness", "computational", + "using", + "including", "could", - "however", - "molecules", - "developed", - "ones", - "distorted" + "increase" ], "release_date":"2021-01-13", "publication":"\"Crystal structures of Scone: pseudosymmetric folding of a symmetric designer protein\", Acta Crystallogr D Struct Biol, 77, 933-942", @@ -394068,15 +395602,15 @@ "seq_thr_sim_designed":[ { "sim":722.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":722.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":722.0, - "partner":"7ax2" + "partner":"7ax0" }, { "sim":586.0, @@ -394132,15 +395666,15 @@ }, { "sim":100.0, - "partner":"8prr" + "partner":"8prf" }, { "sim":100.0, - "partner":"8pre" + "partner":"8prr" }, { "sim":100.0, - "partner":"8prf" + "partner":"8pre" } ], "seq_thr_sim_natural":[ @@ -394152,10 +395686,6 @@ "sim":59.0, "partner":"3q54" }, - { - "sim":59.0, - "partner":"6soj" - }, { "sim":59.0, "partner":"6sn9" @@ -394168,6 +395698,10 @@ "sim":59.0, "partner":"6sob" }, + { + "sim":59.0, + "partner":"6soj" + }, { "sim":59.0, "partner":"8qpu" @@ -394202,11 +395736,11 @@ }, { "sim":59.0, - "partner":"6v05" + "partner":"5d0o" }, { "sim":59.0, - "partner":"5d0o" + "partner":"6v05" }, { "sim":59.0, @@ -394216,10 +395750,6 @@ "sim":59.0, "partner":"4pk1" }, - { - "sim":58.0, - "partner":"6lyq" - }, { "sim":58.0, "partner":"6lyr" @@ -394231,6 +395761,10 @@ { "sim":58.0, "partner":"6lyu" + }, + { + "sim":58.0, + "partner":"6lyq" } ], "struct_thr_sim_designed":[ @@ -394241,7 +395775,7 @@ ], "seq_max_sim_designed":{ "sim":722.0, - "partner":"7ax0" + "partner":"7awz" }, "seq_max_sim_natural":{ "sim":434.0, @@ -394316,51 +395850,51 @@ "beta-propeller" ], "keywords":[ - "crystallization", + "made", + "designed", + "eightfold", + "conformation", + "design", + "revealed", + "adopt", + "however", "propeller", - "designs", - "years", "one", - "proteins", - "usefulness", - "named", - "crystallography", - "including", + "development", + "ones", "crystallized", - "designed", + "named", + "attempts", + "distorted", + "crystallization", + "structure", + "addition", "seen", - "engineer", - "two", - "eightfold", + "recently", + "crystallography", + "protein", + "proteins", "symmetric", + "cake", "leading", + "molecules", "highlighting", - "made", - "addition", - "design", - "additives", - "protein", "upon", - "attempts", - "using", - "adopt", - "conformation", - "termini", - "polyoxometalate", - "development", - "cake", + "years", + "additives", + "two", + "developed", "recent", - "structure", - "revealed", - "recently", - "increase", + "polyoxometalate", + "termini", + "designs", + "engineer", + "usefulness", "computational", + "using", + "including", "could", - "however", - "molecules", - "developed", - "ones", - "distorted" + "increase" ], "release_date":"2021-01-13", "publication":"\"Crystal structures of Scone: pseudosymmetric folding of a symmetric designer protein\", Acta Crystallogr D Struct Biol, 77, 933-942", @@ -394393,11 +395927,11 @@ "seq_thr_sim_designed":[ { "sim":786.0, - "partner":"7ax0" + "partner":"7ax2" }, { "sim":786.0, - "partner":"7ax2" + "partner":"7ax0" }, { "sim":731.0, @@ -394449,15 +395983,15 @@ }, { "sim":96.0, - "partner":"8prr" + "partner":"8prf" }, { "sim":96.0, - "partner":"8pre" + "partner":"8prr" }, { "sim":96.0, - "partner":"8prf" + "partner":"8pre" }, { "sim":96.0, @@ -394477,10 +396011,6 @@ "sim":58.0, "partner":"3q54" }, - { - "sim":58.0, - "partner":"6soj" - }, { "sim":58.0, "partner":"6sn9" @@ -394493,6 +396023,10 @@ "sim":58.0, "partner":"6sob" }, + { + "sim":58.0, + "partner":"6soj" + }, { "sim":58.0, "partner":"8qpu" @@ -394527,11 +396061,11 @@ }, { "sim":58.0, - "partner":"6v05" + "partner":"5d0o" }, { "sim":58.0, - "partner":"5d0o" + "partner":"6v05" }, { "sim":58.0, @@ -394541,10 +396075,6 @@ "sim":58.0, "partner":"4pk1" }, - { - "sim":57.0, - "partner":"6lyq" - }, { "sim":57.0, "partner":"6lyr" @@ -394557,6 +396087,10 @@ "sim":57.0, "partner":"6lyu" }, + { + "sim":57.0, + "partner":"6lyq" + }, { "sim":51.0, "partner":"2yms" @@ -394570,7 +396104,7 @@ ], "seq_max_sim_designed":{ "sim":786.0, - "partner":"7ax0" + "partner":"7ax2" }, "seq_max_sim_natural":{ "sim":450.0, @@ -394645,51 +396179,51 @@ "beta-propeller" ], "keywords":[ - "crystallization", + "made", + "designed", + "eightfold", + "conformation", + "design", + "revealed", + "adopt", + "however", "propeller", - "designs", - "years", "one", - "proteins", - "usefulness", - "named", - "crystallography", - "including", + "development", + "ones", "crystallized", - "designed", + "named", + "attempts", + "distorted", + "crystallization", + "structure", + "addition", "seen", - "engineer", - "two", - "eightfold", + "recently", + "crystallography", + "protein", + "proteins", "symmetric", + "cake", "leading", + "molecules", "highlighting", - "made", - "addition", - "design", - "additives", - "protein", "upon", - "attempts", - "using", - "adopt", - "conformation", - "termini", - "polyoxometalate", - "development", - "cake", + "years", + "additives", + "two", + "developed", "recent", - "structure", - "revealed", - "recently", - "increase", + "polyoxometalate", + "termini", + "designs", + "engineer", + "usefulness", "computational", + "using", + "including", "could", - "however", - "molecules", - "developed", - "ones", - "distorted" + "increase" ], "release_date":"2021-06-30", "publication":"\"Crystal structures of Scone: pseudosymmetric folding of a symmetric designer protein\", Acta Crystallogr D Struct Biol, 77, 933-942", @@ -394778,15 +396312,15 @@ }, { "sim":96.0, - "partner":"8prr" + "partner":"8prf" }, { "sim":96.0, - "partner":"8pre" + "partner":"8prr" }, { "sim":96.0, - "partner":"8prf" + "partner":"8pre" }, { "sim":96.0, @@ -394806,18 +396340,6 @@ "sim":58.0, "partner":"3q54" }, - { - "sim":58.0, - "partner":"6soj" - }, - { - "sim":58.0, - "partner":"6sn4" - }, - { - "sim":58.0, - "partner":"6soc" - }, { "sim":58.0, "partner":"6smx" @@ -394864,11 +396386,11 @@ }, { "sim":58.0, - "partner":"5ljo" + "partner":"6soh" }, { "sim":58.0, - "partner":"6soh" + "partner":"5ljo" }, { "sim":58.0, @@ -394878,6 +396400,18 @@ "sim":58.0, "partner":"6sob" }, + { + "sim":58.0, + "partner":"6soj" + }, + { + "sim":58.0, + "partner":"6sn4" + }, + { + "sim":58.0, + "partner":"6soc" + }, { "sim":58.0, "partner":"8qpu" @@ -394912,27 +396446,27 @@ }, { "sim":58.0, - "partner":"7nbx" + "partner":"5d0o" }, { "sim":58.0, - "partner":"7ncs" + "partner":"7bnq" }, { "sim":58.0, - "partner":"6v05" + "partner":"7nd0" }, { "sim":58.0, - "partner":"5d0o" + "partner":"7nbx" }, { "sim":58.0, - "partner":"7bnq" + "partner":"7ncs" }, { "sim":58.0, - "partner":"7nd0" + "partner":"6v05" }, { "sim":58.0, @@ -394946,10 +396480,6 @@ "sim":57.0, "partner":"7nri" }, - { - "sim":57.0, - "partner":"6lyq" - }, { "sim":57.0, "partner":"6lyr" @@ -394962,6 +396492,10 @@ "sim":57.0, "partner":"6lyu" }, + { + "sim":57.0, + "partner":"6lyq" + }, { "sim":51.0, "partner":"2yms" @@ -395050,51 +396584,51 @@ "beta-propeller" ], "keywords":[ - "crystallization", + "made", + "designed", + "eightfold", + "conformation", + "design", + "revealed", + "adopt", + "however", "propeller", - "designs", - "years", "one", - "proteins", - "usefulness", - "named", - "crystallography", - "including", + "development", + "ones", "crystallized", - "designed", + "named", + "attempts", + "distorted", + "crystallization", + "structure", + "addition", "seen", - "engineer", - "two", - "eightfold", + "recently", + "crystallography", + "protein", + "proteins", "symmetric", + "cake", "leading", + "molecules", "highlighting", - "made", - "addition", - "design", - "additives", - "protein", "upon", - "attempts", - "using", - "adopt", - "conformation", - "termini", - "polyoxometalate", - "development", - "cake", + "years", + "additives", + "two", + "developed", "recent", - "structure", - "revealed", - "recently", - "increase", + "polyoxometalate", + "termini", + "designs", + "engineer", + "usefulness", "computational", + "using", + "including", "could", - "however", - "molecules", - "developed", - "ones", - "distorted" + "increase" ], "release_date":"2021-01-13", "publication":"\"Crystal structures of Scone: pseudosymmetric folding of a symmetric designer protein\", Acta Crystallogr D Struct Biol, 77, 933-942", @@ -395127,11 +396661,11 @@ "seq_thr_sim_designed":[ { "sim":786.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":786.0, - "partner":"7awz" + "partner":"7ax0" }, { "sim":731.0, @@ -395183,15 +396717,15 @@ }, { "sim":96.0, - "partner":"8prr" + "partner":"8prf" }, { "sim":96.0, - "partner":"8pre" + "partner":"8prr" }, { "sim":96.0, - "partner":"8prf" + "partner":"8pre" }, { "sim":96.0, @@ -395211,10 +396745,6 @@ "sim":58.0, "partner":"3q54" }, - { - "sim":58.0, - "partner":"6soj" - }, { "sim":58.0, "partner":"6sn9" @@ -395227,6 +396757,10 @@ "sim":58.0, "partner":"6sob" }, + { + "sim":58.0, + "partner":"6soj" + }, { "sim":58.0, "partner":"8qpu" @@ -395261,11 +396795,11 @@ }, { "sim":58.0, - "partner":"6v05" + "partner":"5d0o" }, { "sim":58.0, - "partner":"5d0o" + "partner":"6v05" }, { "sim":58.0, @@ -395275,10 +396809,6 @@ "sim":58.0, "partner":"4pk1" }, - { - "sim":57.0, - "partner":"6lyq" - }, { "sim":57.0, "partner":"6lyr" @@ -395291,6 +396821,10 @@ "sim":57.0, "partner":"6lyu" }, + { + "sim":57.0, + "partner":"6lyq" + }, { "sim":51.0, "partner":"2yms" @@ -395304,7 +396838,7 @@ ], "seq_max_sim_designed":{ "sim":786.0, - "partner":"7ax0" + "partner":"7awz" }, "seq_max_sim_natural":{ "sim":450.0, @@ -395398,81 +396932,81 @@ ], "subtitle":"Crystal structure of the computationally designed chemically disruptable heterodimer ld6-mdm2", "tags":[ + "protein switches", "protein-protein interaction", - "gene and cell therapy", - "chemically disruptable heterodimer (cdh)", "protein binding", - "protein switches" + "chemically disruptable heterodimer (cdh)", + "gene and cell therapy" ], "keywords":[ - "cdh", + "designed", + "form", + "heterodimers", + "dissociate", + "mammalian", "responses", - "performance", - "control", - "logic", - "excellent", - "circuits", - "many", "critical", - "architecture", - "components", - "release", - "chemical", - "approach", - "strategy", - "inhibitor", - "spaces", - "translational", - "drug", - "including", - "activities", - "dissociate", - "designed", - "responsive", - "receptor", - "presence", - "effectively", - "small", - "expands", + "design", + "however", + "many", + "space", "binders", - "repertoire", - "heterodimers", - "new", + "living", "provides", - "refer", "repurpose", + "responsive", + "expands", + "rationally", + "combinations", + "presence", + "blueprint", + "properties", + "translational", + "synthetic", + "crucial", + "insufficient", "safety", - "design", - "cdhs", - "living", + "inhibitor", + "new", + "strategy", + "release", "airs", + "switches", + "refer", + "control", "protein", - "synthetic", - "insufficient", "interactions", - "applications", - "switches", - "present", - "converted", + "activities", + "spaces", + "performance", "air", "immunogenicity", - "rationally", - "mammalian", - "space", - "showed", - "blueprint", + "drug", + "cdhs", + "circuits", + "approach", + "develop", + "molecules", "cellular", - "computational", - "form", - "however", - "activation", - "combinations", + "showed", + "logic", + "architecture", "cells", - "molecules", + "activation", + "repertoire", + "small", + "components", + "excellent", + "effectively", + "applications", + "present", + "converted", + "chemical", "incorporate", - "crucial", - "properties", - "develop" + "cdh", + "computational", + "including", + "receptor" ], "release_date":"2021-08-18", "publication":"\"A rational blueprint for the design of chemically-controlled protein switches\", Nat Commun, 12, 5754-5754", @@ -395662,87 +397196,87 @@ ], "subtitle":"Broadly neutralizing darpin bnd.1 in complex with the hiv-1 envelope variable loop 3 crown mimetic peptide v3-if (bg505)", "tags":[ - "neutralization", "hiv", - "v3", + "conformation", + "de novo protein", "darpins", "antibodies", - "de novo protein", - "conformation" + "neutralization", + "v3" ], "keywords":[ - "responses", - "neutralization", - "prefusion", + "designed", + "env", + "open", "largely", - "triggered", + "breadth", + "achieve", + "directed", "analysis", - "k", - "rare", + "responses", "preventive", - "cohort", - "results", + "challenging", + "conclusion", + "prefusion", + "revealed", + "conserved", "one", - "proteins", - "accessible", - "attacked", + "indicate", + "role", "conformational", - "neutralizing", - "n", - "focusing", + "repeat", + "loop", + "show", + "development", + "vigorous", + "engagement", + "v3", "bnab", - "antibody", - "principle", - "response", + "approaches", + "cohort", "elicits", - "conserved", - "directed", - "reactivities", - "designed", - "challenging", - "open", - "ankyrin", + "accessible", "residues", - "highly", - "swiss", - "approaches", - "envelope", - "two", - "activity", - "breadth", - "target", + "preferences", + "n", + "results", "considered", - "show", - "env", + "therapeutic", + "target", + "resembles", "protein", "bind", - "conclusion", - "present", - "view", - "engagement", - "supporting", - "resembles", - "development", + "cd4", + "swiss", + "response", + "proteins", + "binding", + "reactivities", "matching", - "bnds", - "repeat", - "revealed", - "indicate", - "vigorous", - "v3", + "ankyrin", + "rare", + "activity", "broadly", + "highly", + "neutralization", + "view", + "neutralizing", + "bnds", + "focusing", "distinct", - "cd4", - "antibodies", - "role", - "achieve", "conformations", - "binding", - "preferences", - "therapeutic", - "loop", + "two", + "principle", + "present", + "whereas", + "envelope", + "k", "bnabs", - "whereas" + "triggered", + "attacked", + "supporting", + "antibodies", + "antibody" ], "release_date":"2021-11-24", "publication":"\"Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization\", Nat Commun, 12, 6705-6705", @@ -395811,11 +397345,11 @@ }, { "sim":267.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":267.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":266.0, @@ -395823,11 +397357,11 @@ }, { "sim":266.0, - "partner":"8a1a" + "partner":"8a19" }, { "sim":266.0, - "partner":"8a19" + "partner":"8a1a" }, { "sim":265.0, @@ -395855,19 +397389,19 @@ }, { "sim":261.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":261.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":261.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":261.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":261.0, @@ -395875,35 +397409,35 @@ }, { "sim":261.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":261.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":261.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":261.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":261.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":261.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":261.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":261.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":261.0, @@ -395927,11 +397461,11 @@ }, { "sim":258.0, - "partner":"7dnf" + "partner":"5knh" }, { "sim":258.0, - "partner":"5knh" + "partner":"7dnf" }, { "sim":258.0, @@ -395979,11 +397513,11 @@ }, { "sim":244.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":244.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":244.0, @@ -396023,7 +397557,7 @@ }, { "sim":239.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":239.0, @@ -396031,7 +397565,7 @@ }, { "sim":239.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":237.0, @@ -396055,11 +397589,11 @@ }, { "sim":219.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":219.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":212.0, @@ -396105,6 +397639,10 @@ "sim":188.0, "partner":"8aiw" }, + { + "sim":188.0, + "partner":"9glq" + }, { "sim":184.0, "partner":"4gmr" @@ -396185,11 +397723,11 @@ }, { "sim":277.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":277.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":277.0, @@ -396221,15 +397759,15 @@ }, { "sim":271.0, - "partner":"4k5a" + "partner":"6d65" }, { "sim":271.0, - "partner":"4k5b" + "partner":"4k5a" }, { "sim":271.0, - "partner":"6d65" + "partner":"4k5b" }, { "sim":270.0, @@ -396297,31 +397835,27 @@ }, { "sim":261.0, - "partner":"5eno" - }, - { - "sim":261.0, - "partner":"6zob" + "partner":"4dx6" }, { "sim":261.0, - "partner":"6zo5" + "partner":"6mzf" }, { "sim":261.0, - "partner":"6mzf" + "partner":"6sgs" }, { "sim":261.0, - "partner":"4dx6" + "partner":"6zoc" }, { "sim":261.0, - "partner":"6q4n" + "partner":"6mze" }, { "sim":261.0, - "partner":"6zoc" + "partner":"6zo6" }, { "sim":261.0, @@ -396333,27 +397867,27 @@ }, { "sim":261.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":261.0, - "partner":"6mze" + "partner":"7ac5" }, { "sim":261.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":261.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":261.0, - "partner":"5nqu" + "partner":"4dx7" }, { "sim":261.0, - "partner":"6q4o" + "partner":"5nqu" }, { "sim":261.0, @@ -396361,15 +397895,11 @@ }, { "sim":261.0, - "partner":"6zod" - }, - { - "sim":261.0, - "partner":"7ac5" + "partner":"6zo7" }, { "sim":261.0, - "partner":"7b8r" + "partner":"6zoe" }, { "sim":261.0, @@ -396377,19 +397907,15 @@ }, { "sim":261.0, - "partner":"6zo7" - }, - { - "sim":261.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":261.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":261.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":261.0, @@ -396401,19 +397927,19 @@ }, { "sim":261.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":261.0, - "partner":"4lnu" + "partner":"6zof" }, { "sim":261.0, - "partner":"6zo8" + "partner":"4lnu" }, { "sim":261.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":261.0, @@ -396425,23 +397951,23 @@ }, { "sim":261.0, - "partner":"6sgu" + "partner":"7b8t" }, { "sim":261.0, - "partner":"5nc5" + "partner":"6zo9" }, { "sim":261.0, - "partner":"6zo9" + "partner":"6zog" }, { "sim":261.0, - "partner":"6zog" + "partner":"5nc5" }, { "sim":261.0, - "partner":"7b8t" + "partner":"6zwb" }, { "sim":261.0, @@ -396461,27 +397987,27 @@ }, { "sim":261.0, - "partner":"6zwb" + "partner":"5en5" }, { "sim":261.0, - "partner":"5en5" + "partner":"6zoa" }, { "sim":261.0, - "partner":"4u8y" + "partner":"6zoh" }, { "sim":261.0, - "partner":"6zoa" + "partner":"6zwc" }, { "sim":261.0, - "partner":"6zoh" + "partner":"4u8y" }, { "sim":261.0, - "partner":"6zwc" + "partner":"6sgr" }, { "sim":261.0, @@ -396497,12 +398023,24 @@ }, { "sim":261.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":261.0, "partner":"4dx5" }, + { + "sim":261.0, + "partner":"5eno" + }, + { + "sim":261.0, + "partner":"6zo5" + }, + { + "sim":261.0, + "partner":"6q4n" + }, { "sim":261.0, "partner":"7n2b" @@ -396537,11 +398075,11 @@ }, { "sim":257.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":257.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":257.0, @@ -396709,11 +398247,11 @@ }, { "sim":235.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":235.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":234.0, @@ -396737,11 +398275,11 @@ }, { "sim":218.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":218.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":218.0, @@ -396943,10 +398481,6 @@ "sim":111.0, "partner":"5vkq" }, - { - "sim":109.0, - "partner":"5vhj" - }, { "sim":109.0, "partner":"5vhh" @@ -396975,6 +398509,10 @@ "sim":109.0, "partner":"5vho" }, + { + "sim":109.0, + "partner":"5vhj" + }, { "sim":109.0, "partner":"5vhp" @@ -397001,15 +398539,15 @@ }, { "sim":109.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":109.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":109.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":106.0, @@ -397037,15 +398575,15 @@ }, { "sim":103.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":103.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":103.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":102.0, @@ -397141,11 +398679,11 @@ }, { "sim":98.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":98.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":98.0, @@ -397161,11 +398699,11 @@ }, { "sim":95.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":95.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":95.0, @@ -397365,19 +398903,19 @@ }, { "sim":81.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":81.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":81.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":81.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":79.0, @@ -397451,10 +398989,6 @@ "sim":77.0, "partner":"6wj5" }, - { - "sim":77.0, - "partner":"6v9x" - }, { "sim":77.0, "partner":"6v9y" @@ -397467,6 +399001,10 @@ "sim":77.0, "partner":"6v9w" }, + { + "sim":77.0, + "partner":"6v9x" + }, { "sim":77.0, "partner":"6pqo" @@ -397501,15 +399039,15 @@ }, { "sim":75.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":75.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":75.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":74.0, @@ -397517,20 +399055,16 @@ }, { "sim":73.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":73.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":72.0, "partner":"5wo6" }, - { - "sim":72.0, - "partner":"5iwr" - }, { "sim":72.0, "partner":"5iwt" @@ -397585,11 +399119,11 @@ }, { "sim":72.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":72.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":72.0, @@ -397627,6 +399161,10 @@ "sim":72.0, "partner":"6dmw" }, + { + "sim":72.0, + "partner":"6o1p" + }, { "sim":71.0, "partner":"8pef" @@ -397679,10 +399217,6 @@ "sim":67.0, "partner":"3t9k" }, - { - "sim":65.0, - "partner":"7k4a" - }, { "sim":65.0, "partner":"7k4b" @@ -397705,7 +399239,7 @@ }, { "sim":65.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":65.0, @@ -397721,11 +399255,11 @@ }, { "sim":65.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":65.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":65.0, @@ -397743,6 +399277,10 @@ "sim":65.0, "partner":"6bo8" }, + { + "sim":65.0, + "partner":"6bo9" + }, { "sim":64.0, "partner":"5cer" @@ -397842,6 +399380,10 @@ { "sim":50.0, "partner":"6l93" + }, + { + "sim":50.0, + "partner":"8ycp" } ], "struct_thr_sim_designed":[ @@ -398096,87 +399638,87 @@ ], "subtitle":"Broadly neutralizing darpin bnd.2 in complex with the hiv-1 envelope variable loop 3 crown mimetic peptide v3-if (bg505)", "tags":[ - "neutralization", "hiv", - "v3", + "conformation", + "de novo protein", "darpins", "antibodies", - "de novo protein", - "conformation" + "neutralization", + "v3" ], "keywords":[ - "responses", - "neutralization", - "prefusion", + "designed", + "env", + "open", "largely", - "triggered", + "breadth", + "achieve", + "directed", "analysis", - "k", - "rare", + "responses", "preventive", - "cohort", - "results", + "challenging", + "conclusion", + "prefusion", + "revealed", + "conserved", "one", - "proteins", - "accessible", - "attacked", + "indicate", + "role", "conformational", - "neutralizing", - "n", - "focusing", + "repeat", + "loop", + "show", + "development", + "vigorous", + "engagement", + "v3", "bnab", - "antibody", - "principle", - "response", + "approaches", + "cohort", "elicits", - "conserved", - "directed", - "reactivities", - "designed", - "challenging", - "open", - "ankyrin", + "accessible", "residues", - "highly", - "swiss", - "approaches", - "envelope", - "two", - "activity", - "breadth", - "target", + "preferences", + "n", + "results", "considered", - "show", - "env", + "therapeutic", + "target", + "resembles", "protein", "bind", - "conclusion", - "present", - "view", - "engagement", - "supporting", - "resembles", - "development", + "cd4", + "swiss", + "response", + "proteins", + "binding", + "reactivities", "matching", - "bnds", - "repeat", - "revealed", - "indicate", - "vigorous", - "v3", + "ankyrin", + "rare", + "activity", "broadly", + "highly", + "neutralization", + "view", + "neutralizing", + "bnds", + "focusing", "distinct", - "cd4", - "antibodies", - "role", - "achieve", "conformations", - "binding", - "preferences", - "therapeutic", - "loop", + "two", + "principle", + "present", + "whereas", + "envelope", + "k", "bnabs", - "whereas" + "triggered", + "attacked", + "supporting", + "antibodies", + "antibody" ], "release_date":"2021-11-24", "publication":"\"Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization\", Nat Commun, 12, 6705-6705", @@ -398273,19 +399815,19 @@ }, { "sim":206.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":206.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":206.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":206.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":206.0, @@ -398293,35 +399835,35 @@ }, { "sim":206.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":206.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":206.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":206.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":206.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":206.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":206.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":206.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":205.0, @@ -398355,6 +399897,10 @@ "sim":198.0, "partner":"5knh" }, + { + "sim":197.0, + "partner":"9glq" + }, { "sim":197.0, "partner":"8aed" @@ -398369,11 +399915,11 @@ }, { "sim":196.0, - "partner":"5oos" + "partner":"5op3" }, { "sim":196.0, - "partner":"5op3" + "partner":"5oos" }, { "sim":195.0, @@ -398393,11 +399939,11 @@ }, { "sim":194.0, - "partner":"4j7w" + "partner":"7dnf" }, { "sim":194.0, - "partner":"7dnf" + "partner":"4j7w" }, { "sim":194.0, @@ -398481,7 +400027,7 @@ }, { "sim":179.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":179.0, @@ -398489,7 +400035,7 @@ }, { "sim":179.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":177.0, @@ -398501,11 +400047,11 @@ }, { "sim":177.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":177.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":177.0, @@ -398529,11 +400075,11 @@ }, { "sim":156.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":156.0, - "partner":"4qfv" + "partner":"4o60" }, { "sim":144.0, @@ -398549,11 +400095,11 @@ }, { "sim":136.0, - "partner":"4gpm" + "partner":"5hry" }, { "sim":136.0, - "partner":"5hry" + "partner":"4gpm" }, { "sim":134.0, @@ -398599,11 +400145,11 @@ }, { "sim":216.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":216.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":216.0, @@ -398685,13 +400231,17 @@ "sim":206.0, "partner":"6mzf" }, + { + "sim":206.0, + "partner":"6mze" + }, { "sim":206.0, "partner":"5nqt" }, { "sim":206.0, - "partner":"6mze" + "partner":"7ac5" }, { "sim":206.0, @@ -398699,11 +400249,11 @@ }, { "sim":206.0, - "partner":"7ac5" + "partner":"4lnu" }, { "sim":206.0, - "partner":"4lnu" + "partner":"6zwb" }, { "sim":206.0, @@ -398717,10 +400267,6 @@ "sim":206.0, "partner":"5nm5" }, - { - "sim":206.0, - "partner":"6zwb" - }, { "sim":206.0, "partner":"6zwc" @@ -398755,11 +400301,11 @@ }, { "sim":201.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":201.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":201.0, @@ -398853,10 +400399,6 @@ "sim":195.0, "partner":"6moe" }, - { - "sim":195.0, - "partner":"5oyj" - }, { "sim":195.0, "partner":"2p2c" @@ -398869,6 +400411,10 @@ "sim":195.0, "partner":"6d65" }, + { + "sim":195.0, + "partner":"5oyj" + }, { "sim":194.0, "partner":"6h46" @@ -398893,45 +400439,25 @@ "sim":194.0, "partner":"4k5c" }, - { - "sim":192.0, - "partner":"5eno" - }, - { - "sim":192.0, - "partner":"6zob" - }, - { - "sim":192.0, - "partner":"6zo5" - }, { "sim":192.0, "partner":"4dx6" }, { "sim":192.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":192.0, "partner":"6zoc" }, - { - "sim":192.0, - "partner":"5enp" - }, - { - "sim":192.0, - "partner":"6sgs" - }, { "sim":192.0, "partner":"6zo6" }, { "sim":192.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":192.0, @@ -398939,7 +400465,7 @@ }, { "sim":192.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":192.0, @@ -398947,11 +400473,11 @@ }, { "sim":192.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":192.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":192.0, @@ -398961,6 +400487,10 @@ "sim":192.0, "partner":"6zoe" }, + { + "sim":192.0, + "partner":"5enq" + }, { "sim":192.0, "partner":"6q4p" @@ -398971,15 +400501,15 @@ }, { "sim":192.0, - "partner":"2j8s" + "partner":"7b8s" }, { "sim":192.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":192.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":192.0, @@ -398991,35 +400521,35 @@ }, { "sim":192.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":192.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":192.0, - "partner":"6sgu" + "partner":"4u8v" }, { "sim":192.0, - "partner":"2y1l" + "partner":"7b8t" }, { "sim":192.0, - "partner":"5nc5" + "partner":"6zo9" }, { "sim":192.0, - "partner":"6zo9" + "partner":"6zog" }, { "sim":192.0, - "partner":"6zog" + "partner":"2y1l" }, { "sim":192.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":192.0, @@ -399031,15 +400561,19 @@ }, { "sim":192.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":192.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":192.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":192.0, + "partner":"6sgr" }, { "sim":192.0, @@ -399055,12 +400589,24 @@ }, { "sim":192.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":192.0, "partner":"4dx5" }, + { + "sim":192.0, + "partner":"5eno" + }, + { + "sim":192.0, + "partner":"6zo5" + }, + { + "sim":192.0, + "partner":"6q4n" + }, { "sim":192.0, "partner":"5mla" @@ -399211,11 +400757,11 @@ }, { "sim":172.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":172.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":172.0, @@ -399239,11 +400785,11 @@ }, { "sim":168.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":168.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":165.0, @@ -399325,10 +400871,6 @@ "sim":83.0, "partner":"6if3" }, - { - "sim":83.0, - "partner":"5vhj" - }, { "sim":83.0, "partner":"5vhh" @@ -399357,6 +400899,10 @@ "sim":83.0, "partner":"5vho" }, + { + "sim":83.0, + "partner":"5vhj" + }, { "sim":83.0, "partner":"5vhp" @@ -399391,19 +400937,19 @@ }, { "sim":82.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":82.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":82.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":82.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":82.0, @@ -399519,11 +401065,11 @@ }, { "sim":77.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":77.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":77.0, @@ -399563,15 +401109,15 @@ }, { "sim":76.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":76.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":76.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":76.0, @@ -399643,11 +401189,11 @@ }, { "sim":69.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":69.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":69.0, @@ -399757,10 +401303,6 @@ "sim":59.0, "partner":"3ehr" }, - { - "sim":59.0, - "partner":"6v9x" - }, { "sim":59.0, "partner":"6v9y" @@ -399773,6 +401315,10 @@ "sim":59.0, "partner":"6v9w" }, + { + "sim":59.0, + "partner":"6v9x" + }, { "sim":59.0, "partner":"6pqo" @@ -400050,87 +401596,87 @@ ], "subtitle":"Broadly neutralizing darpin bnd.2 in complex with the hiv-1 envelope variable loop 3 crown mimetic peptide v3-if (bg505)", "tags":[ - "neutralization", "hiv", - "v3", + "conformation", + "de novo protein", "darpins", "antibodies", - "de novo protein", - "conformation" + "neutralization", + "v3" ], "keywords":[ - "responses", - "neutralization", - "prefusion", + "designed", + "env", + "open", "largely", - "triggered", + "breadth", + "achieve", + "directed", "analysis", - "k", - "rare", + "responses", "preventive", - "cohort", - "results", + "challenging", + "conclusion", + "prefusion", + "revealed", + "conserved", "one", - "proteins", - "accessible", - "attacked", + "indicate", + "role", "conformational", - "neutralizing", - "n", - "focusing", + "repeat", + "loop", + "show", + "development", + "vigorous", + "engagement", + "v3", "bnab", - "antibody", - "principle", - "response", + "approaches", + "cohort", "elicits", - "conserved", - "directed", - "reactivities", - "designed", - "challenging", - "open", - "ankyrin", + "accessible", "residues", - "highly", - "swiss", - "approaches", - "envelope", - "two", - "activity", - "breadth", - "target", + "preferences", + "n", + "results", "considered", - "show", - "env", + "therapeutic", + "target", + "resembles", "protein", "bind", - "conclusion", - "present", - "view", - "engagement", - "supporting", - "resembles", - "development", + "cd4", + "swiss", + "response", + "proteins", + "binding", + "reactivities", "matching", - "bnds", - "repeat", - "revealed", - "indicate", - "vigorous", - "v3", + "ankyrin", + "rare", + "activity", "broadly", + "highly", + "neutralization", + "view", + "neutralizing", + "bnds", + "focusing", "distinct", - "cd4", - "antibodies", - "role", - "achieve", "conformations", - "binding", - "preferences", - "therapeutic", - "loop", + "two", + "principle", + "present", + "whereas", + "envelope", + "k", "bnabs", - "whereas" + "triggered", + "attacked", + "supporting", + "antibodies", + "antibody" ], "release_date":"2021-11-24", "publication":"\"Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization\", Nat Commun, 12, 6705-6705", @@ -400227,19 +401773,19 @@ }, { "sim":206.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":206.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":206.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":206.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":206.0, @@ -400247,35 +401793,35 @@ }, { "sim":206.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":206.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":206.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":206.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":206.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":206.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":206.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":206.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":205.0, @@ -400309,6 +401855,10 @@ "sim":198.0, "partner":"5knh" }, + { + "sim":197.0, + "partner":"9glq" + }, { "sim":197.0, "partner":"8aed" @@ -400323,11 +401873,11 @@ }, { "sim":196.0, - "partner":"5oos" + "partner":"5op3" }, { "sim":196.0, - "partner":"5op3" + "partner":"5oos" }, { "sim":195.0, @@ -400347,11 +401897,11 @@ }, { "sim":194.0, - "partner":"4j7w" + "partner":"7dnf" }, { "sim":194.0, - "partner":"7dnf" + "partner":"4j7w" }, { "sim":194.0, @@ -400435,7 +401985,7 @@ }, { "sim":179.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":179.0, @@ -400443,7 +401993,7 @@ }, { "sim":179.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":177.0, @@ -400455,11 +402005,11 @@ }, { "sim":177.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":177.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":177.0, @@ -400483,11 +402033,11 @@ }, { "sim":156.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":156.0, - "partner":"4qfv" + "partner":"4o60" }, { "sim":144.0, @@ -400503,11 +402053,11 @@ }, { "sim":136.0, - "partner":"4gpm" + "partner":"5hry" }, { "sim":136.0, - "partner":"5hry" + "partner":"4gpm" }, { "sim":134.0, @@ -400553,11 +402103,11 @@ }, { "sim":216.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":216.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":216.0, @@ -400639,13 +402189,17 @@ "sim":206.0, "partner":"6mzf" }, + { + "sim":206.0, + "partner":"6mze" + }, { "sim":206.0, "partner":"5nqt" }, { "sim":206.0, - "partner":"6mze" + "partner":"7ac5" }, { "sim":206.0, @@ -400653,11 +402207,11 @@ }, { "sim":206.0, - "partner":"7ac5" + "partner":"4lnu" }, { "sim":206.0, - "partner":"4lnu" + "partner":"6zwb" }, { "sim":206.0, @@ -400671,10 +402225,6 @@ "sim":206.0, "partner":"5nm5" }, - { - "sim":206.0, - "partner":"6zwb" - }, { "sim":206.0, "partner":"6zwc" @@ -400709,11 +402259,11 @@ }, { "sim":201.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":201.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":201.0, @@ -400807,10 +402357,6 @@ "sim":195.0, "partner":"6moe" }, - { - "sim":195.0, - "partner":"5oyj" - }, { "sim":195.0, "partner":"2p2c" @@ -400823,6 +402369,10 @@ "sim":195.0, "partner":"6d65" }, + { + "sim":195.0, + "partner":"5oyj" + }, { "sim":194.0, "partner":"6h46" @@ -400847,45 +402397,25 @@ "sim":194.0, "partner":"4k5c" }, - { - "sim":192.0, - "partner":"5eno" - }, - { - "sim":192.0, - "partner":"6zob" - }, - { - "sim":192.0, - "partner":"6zo5" - }, { "sim":192.0, "partner":"4dx6" }, { "sim":192.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":192.0, "partner":"6zoc" }, - { - "sim":192.0, - "partner":"5enp" - }, - { - "sim":192.0, - "partner":"6sgs" - }, { "sim":192.0, "partner":"6zo6" }, { "sim":192.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":192.0, @@ -400893,7 +402423,7 @@ }, { "sim":192.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":192.0, @@ -400901,11 +402431,11 @@ }, { "sim":192.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":192.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":192.0, @@ -400915,6 +402445,10 @@ "sim":192.0, "partner":"6zoe" }, + { + "sim":192.0, + "partner":"5enq" + }, { "sim":192.0, "partner":"6q4p" @@ -400925,15 +402459,15 @@ }, { "sim":192.0, - "partner":"2j8s" + "partner":"7b8s" }, { "sim":192.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":192.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":192.0, @@ -400945,35 +402479,35 @@ }, { "sim":192.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":192.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":192.0, - "partner":"6sgu" + "partner":"4u8v" }, { "sim":192.0, - "partner":"2y1l" + "partner":"7b8t" }, { "sim":192.0, - "partner":"5nc5" + "partner":"6zo9" }, { "sim":192.0, - "partner":"6zo9" + "partner":"6zog" }, { "sim":192.0, - "partner":"6zog" + "partner":"2y1l" }, { "sim":192.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":192.0, @@ -400985,15 +402519,19 @@ }, { "sim":192.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":192.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":192.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":192.0, + "partner":"6sgr" }, { "sim":192.0, @@ -401009,12 +402547,24 @@ }, { "sim":192.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":192.0, "partner":"4dx5" }, + { + "sim":192.0, + "partner":"5eno" + }, + { + "sim":192.0, + "partner":"6zo5" + }, + { + "sim":192.0, + "partner":"6q4n" + }, { "sim":192.0, "partner":"5mla" @@ -401165,11 +402715,11 @@ }, { "sim":172.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":172.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":172.0, @@ -401193,11 +402743,11 @@ }, { "sim":168.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":168.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":165.0, @@ -401279,10 +402829,6 @@ "sim":83.0, "partner":"6if3" }, - { - "sim":83.0, - "partner":"5vhj" - }, { "sim":83.0, "partner":"5vhh" @@ -401311,6 +402857,10 @@ "sim":83.0, "partner":"5vho" }, + { + "sim":83.0, + "partner":"5vhj" + }, { "sim":83.0, "partner":"5vhp" @@ -401345,19 +402895,19 @@ }, { "sim":82.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":82.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":82.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":82.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":82.0, @@ -401473,11 +403023,11 @@ }, { "sim":77.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":77.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":77.0, @@ -401517,15 +403067,15 @@ }, { "sim":76.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":76.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":76.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":76.0, @@ -401597,11 +403147,11 @@ }, { "sim":69.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":69.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":69.0, @@ -401711,10 +403261,6 @@ "sim":59.0, "partner":"3ehr" }, - { - "sim":59.0, - "partner":"6v9x" - }, { "sim":59.0, "partner":"6v9y" @@ -401727,6 +403273,10 @@ "sim":59.0, "partner":"6v9w" }, + { + "sim":59.0, + "partner":"6v9x" + }, { "sim":59.0, "partner":"6pqo" @@ -402004,87 +403554,87 @@ ], "subtitle":"Broadly neutralizing darpin bnd.3 in complex with the hiv-1 envelope variable loop 3 crown mimetic peptide v3-if (bg505)", "tags":[ - "neutralization", "hiv", - "v3", + "conformation", + "de novo protein", "darpins", "antibodies", - "de novo protein", - "conformation" + "neutralization", + "v3" ], "keywords":[ - "responses", - "neutralization", - "prefusion", + "designed", + "env", + "open", "largely", - "triggered", + "breadth", + "achieve", + "directed", "analysis", - "k", - "rare", + "responses", "preventive", - "cohort", - "results", + "challenging", + "conclusion", + "prefusion", + "revealed", + "conserved", "one", - "proteins", - "accessible", - "attacked", + "indicate", + "role", "conformational", - "neutralizing", - "n", - "focusing", + "repeat", + "loop", + "show", + "development", + "vigorous", + "engagement", + "v3", "bnab", - "antibody", - "principle", - "response", + "approaches", + "cohort", "elicits", - "conserved", - "directed", - "reactivities", - "designed", - "challenging", - "open", - "ankyrin", + "accessible", "residues", - "highly", - "swiss", - "approaches", - "envelope", - "two", - "activity", - "breadth", - "target", + "preferences", + "n", + "results", "considered", - "show", - "env", + "therapeutic", + "target", + "resembles", "protein", "bind", - "conclusion", - "present", - "view", - "engagement", - "supporting", - "resembles", - "development", + "cd4", + "swiss", + "response", + "proteins", + "binding", + "reactivities", "matching", - "bnds", - "repeat", - "revealed", - "indicate", - "vigorous", - "v3", + "ankyrin", + "rare", + "activity", "broadly", + "highly", + "neutralization", + "view", + "neutralizing", + "bnds", + "focusing", "distinct", - "cd4", - "antibodies", - "role", - "achieve", "conformations", - "binding", - "preferences", - "therapeutic", - "loop", + "two", + "principle", + "present", + "whereas", + "envelope", + "k", "bnabs", - "whereas" + "triggered", + "attacked", + "supporting", + "antibodies", + "antibody" ], "release_date":"2021-11-24", "publication":"\"Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization\", Nat Commun, 12, 6705-6705", @@ -402215,33 +403765,29 @@ "sim":258.0, "partner":"2bkg" }, - { - "sim":258.0, - "partner":"4j8y" - }, { "sim":258.0, "partner":"4j7w" }, { - "sim":256.0, - "partner":"4ydw" + "sim":258.0, + "partner":"4j8y" }, { "sim":256.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":256.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":256.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":256.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":256.0, @@ -402249,27 +403795,27 @@ }, { "sim":256.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":256.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":256.0, - "partner":"7dnf" + "partner":"8qlb" }, { "sim":256.0, - "partner":"8ql6" + "partner":"4ydw" }, { "sim":256.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":256.0, - "partner":"8ql4" + "partner":"7dnf" }, { "sim":256.0, @@ -402277,16 +403823,20 @@ }, { "sim":256.0, - "partner":"8qlb" + "partner":"7dng" }, { "sim":256.0, - "partner":"7dng" + "partner":"8ql4" }, { "sim":256.0, "partner":"8ql2" }, + { + "sim":256.0, + "partner":"8ql5" + }, { "sim":254.0, "partner":"9f22" @@ -402337,7 +403887,7 @@ }, { "sim":242.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":242.0, @@ -402345,7 +403895,7 @@ }, { "sim":242.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":241.0, @@ -402377,11 +403927,11 @@ }, { "sim":235.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":235.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":235.0, @@ -402401,11 +403951,11 @@ }, { "sim":219.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":219.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":210.0, @@ -402447,6 +403997,10 @@ "sim":188.0, "partner":"8aiw" }, + { + "sim":184.0, + "partner":"9glq" + }, { "sim":184.0, "partner":"4gmr" @@ -402527,11 +404081,11 @@ }, { "sim":272.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":272.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":272.0, @@ -402675,15 +404229,11 @@ }, { "sim":256.0, - "partner":"5eno" - }, - { - "sim":256.0, - "partner":"6zob" + "partner":"4dx6" }, { "sim":256.0, - "partner":"6zo5" + "partner":"4ydy" }, { "sim":256.0, @@ -402691,19 +404241,19 @@ }, { "sim":256.0, - "partner":"4dx6" + "partner":"6sgs" }, { "sim":256.0, - "partner":"4ydy" + "partner":"6zoc" }, { "sim":256.0, - "partner":"6q4n" + "partner":"6mze" }, { "sim":256.0, - "partner":"6zoc" + "partner":"6zo6" }, { "sim":256.0, @@ -402715,27 +404265,27 @@ }, { "sim":256.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":256.0, - "partner":"6mze" + "partner":"7ac5" }, { "sim":256.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":256.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":256.0, - "partner":"5nqu" + "partner":"4dx7" }, { "sim":256.0, - "partner":"6q4o" + "partner":"5nqu" }, { "sim":256.0, @@ -402743,15 +404293,11 @@ }, { "sim":256.0, - "partner":"6zod" - }, - { - "sim":256.0, - "partner":"7ac5" + "partner":"6zo7" }, { "sim":256.0, - "partner":"7b8r" + "partner":"6zoe" }, { "sim":256.0, @@ -402759,19 +404305,15 @@ }, { "sim":256.0, - "partner":"6zo7" - }, - { - "sim":256.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":256.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":256.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":256.0, @@ -402783,19 +404325,19 @@ }, { "sim":256.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":256.0, - "partner":"4lnu" + "partner":"6zof" }, { "sim":256.0, - "partner":"6zo8" + "partner":"4lnu" }, { "sim":256.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":256.0, @@ -402807,23 +404349,23 @@ }, { "sim":256.0, - "partner":"6sgu" + "partner":"7b8t" }, { "sim":256.0, - "partner":"5nc5" + "partner":"6zo9" }, { "sim":256.0, - "partner":"6zo9" + "partner":"6zog" }, { "sim":256.0, - "partner":"6zog" + "partner":"5nc5" }, { "sim":256.0, - "partner":"7b8t" + "partner":"6zwb" }, { "sim":256.0, @@ -402843,27 +404385,27 @@ }, { "sim":256.0, - "partner":"6zwb" + "partner":"5en5" }, { "sim":256.0, - "partner":"5en5" + "partner":"6zoa" }, { "sim":256.0, - "partner":"4u8y" + "partner":"6zoh" }, { "sim":256.0, - "partner":"6zoa" + "partner":"6zwc" }, { "sim":256.0, - "partner":"6zoh" + "partner":"4u8y" }, { "sim":256.0, - "partner":"6zwc" + "partner":"6sgr" }, { "sim":256.0, @@ -402879,12 +404421,24 @@ }, { "sim":256.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":256.0, "partner":"4dx5" }, + { + "sim":256.0, + "partner":"5eno" + }, + { + "sim":256.0, + "partner":"6zo5" + }, + { + "sim":256.0, + "partner":"6q4n" + }, { "sim":255.0, "partner":"7alr" @@ -402903,11 +404457,11 @@ }, { "sim":254.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":254.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":254.0, @@ -403051,11 +404605,11 @@ }, { "sim":232.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":232.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":232.0, @@ -403079,11 +404633,11 @@ }, { "sim":222.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":222.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":220.0, @@ -403273,10 +404827,6 @@ "sim":112.0, "partner":"5gp7" }, - { - "sim":112.0, - "partner":"5vhj" - }, { "sim":112.0, "partner":"5vhh" @@ -403305,6 +404855,10 @@ "sim":112.0, "partner":"5vho" }, + { + "sim":112.0, + "partner":"5vhj" + }, { "sim":112.0, "partner":"5vhp" @@ -403335,15 +404889,15 @@ }, { "sim":111.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":111.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":111.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":111.0, @@ -403391,11 +404945,11 @@ }, { "sim":100.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":100.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":100.0, @@ -403411,15 +404965,15 @@ }, { "sim":98.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":98.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":98.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":96.0, @@ -403499,11 +405053,11 @@ }, { "sim":93.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":93.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":93.0, @@ -403655,19 +405209,19 @@ }, { "sim":83.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":83.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":83.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":83.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":83.0, @@ -403697,10 +405251,6 @@ "sim":83.0, "partner":"4oav" }, - { - "sim":82.0, - "partner":"6v9x" - }, { "sim":82.0, "partner":"6v9y" @@ -403713,6 +405263,10 @@ "sim":82.0, "partner":"6v9w" }, + { + "sim":82.0, + "partner":"6v9x" + }, { "sim":82.0, "partner":"6pqo" @@ -403745,14 +405299,6 @@ "sim":79.0, "partner":"1wg0" }, - { - "sim":79.0, - "partner":"6m11" - }, - { - "sim":79.0, - "partner":"6m12" - }, { "sim":79.0, "partner":"6m13" @@ -403777,6 +405323,14 @@ "sim":79.0, "partner":"4o1p" }, + { + "sim":79.0, + "partner":"6m11" + }, + { + "sim":79.0, + "partner":"6m12" + }, { "sim":77.0, "partner":"6if3" @@ -403799,11 +405353,11 @@ }, { "sim":76.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":76.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":75.0, @@ -403819,11 +405373,11 @@ }, { "sim":74.0, - "partner":"5z2n" + "partner":"1d9s" }, { "sim":74.0, - "partner":"1d9s" + "partner":"5z2n" }, { "sim":74.0, @@ -403869,10 +405423,6 @@ "sim":72.0, "partner":"2rfa" }, - { - "sim":72.0, - "partner":"6o1p" - }, { "sim":72.0, "partner":"6b5v" @@ -403910,8 +405460,8 @@ "partner":"6dmw" }, { - "sim":71.0, - "partner":"2a5e" + "sim":72.0, + "partner":"6o1p" }, { "sim":71.0, @@ -403921,6 +405471,10 @@ "sim":71.0, "partner":"1a5e" }, + { + "sim":71.0, + "partner":"2a5e" + }, { "sim":71.0, "partner":"4f1p" @@ -403937,10 +405491,6 @@ "sim":71.0, "partner":"5wo6" }, - { - "sim":71.0, - "partner":"5iwr" - }, { "sim":71.0, "partner":"5iwt" @@ -403993,6 +405543,10 @@ "sim":71.0, "partner":"5iwp" }, + { + "sim":71.0, + "partner":"5iwr" + }, { "sim":71.0, "partner":"5wo7" @@ -404065,10 +405619,6 @@ "sim":63.0, "partner":"6emk" }, - { - "sim":63.0, - "partner":"7k4a" - }, { "sim":63.0, "partner":"7k4b" @@ -404091,7 +405641,7 @@ }, { "sim":63.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":63.0, @@ -404107,11 +405657,11 @@ }, { "sim":63.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":63.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":63.0, @@ -404129,6 +405679,10 @@ "sim":63.0, "partner":"6bo8" }, + { + "sim":63.0, + "partner":"6bo9" + }, { "sim":61.0, "partner":"2fo1" @@ -404221,10 +405775,6 @@ "sim":51.0, "partner":"5is0" }, - { - "sim":51.0, - "partner":"7mzc" - }, { "sim":51.0, "partner":"7l2v" @@ -404285,6 +405835,10 @@ "sim":51.0, "partner":"7mzb" }, + { + "sim":51.0, + "partner":"7mzc" + }, { "sim":51.0, "partner":"6bwj" @@ -404309,10 +405863,6 @@ "sim":51.0, "partner":"6oo7" }, - { - "sim":51.0, - "partner":"7l2n" - }, { "sim":51.0, "partner":"7l2o" @@ -404347,19 +405897,19 @@ }, { "sim":51.0, - "partner":"7lqy" + "partner":"7l2n" }, { "sim":51.0, - "partner":"7lqz" + "partner":"7lqy" }, { "sim":51.0, - "partner":"7lr0" + "partner":"7lqz" }, { "sim":51.0, - "partner":"7lpd" + "partner":"7lr0" }, { "sim":51.0, @@ -404381,6 +405931,10 @@ "sim":51.0, "partner":"7lpc" }, + { + "sim":51.0, + "partner":"7lpd" + }, { "sim":50.0, "partner":"4n5q" @@ -404650,99 +406204,99 @@ ], "subtitle":"A de novo pentameric coiled-coil assembly: cc-type2-(tglaid)4-w19brphe", "tags":[ - "barrel", - "alpha", + "pentamer", "helical", "de novo protein", - "pentamer" + "alpha", + "barrel" ], "keywords":[ - "amphipathic", - "oligomers", - "z", - "pentameric", - "must", - "discriminate", - "pattern", - "controllably", - "accessed", + "made", + "repeats", "allow", - "dimeric", - "smaller", - "crystal", - "target", + "hydrophobic", "show", - "sequences", + "glycine", "closer", - "however", - "alternative", - "expanding", - "contacts", - "direct", - "forces", - "interfaces", - "progressively", - "larger", - "unique", - "de", - "h", - "produce", + "pattern", + "side", + "accessed", + "short", + "residue", + "pentameric", "linear", - "nonetheless", - "point", - "hpphppp", + "helical", + "tetrameric", + "novo", + "controllably", + "hpphhph", + "crystal", + "predictably", + "weak", + "helices", + "chains", + "water", + "alternative", + "however", + "bundles", "decreasing", - "resulting", - "short", - "made", - "assemble", + "p", + "nonameric", + "residues", + "helix", "gives", - "structures", - "assembly", + "polar", + "progressively", + "contacts", + "sites", "size", - "alanine", - "predictably", - "considerable", - "directly", - "serine", - "assemblies", - "bundles", - "four", - "glycine", - "challenging", + "hpphppp", + "larger", + "nominally", + "threonine", "stabilize", + "four", + "serine", + "direct", "design", - "encode", - "avoid", - "helical", - "weak", + "challenging", + "must", + "discriminate", + "produce", + "assembly", + "alanine", + "point", + "forces", + "varying", + "rationalize", "states", - "hydrophobic", - "progress", "sequence", - "repeats", - "rationalize", - "threonine", - "tetrameric", - "sites", - "chains", + "peptides", + "encode", + "expanding", + "nonetheless", + "unique", + "assemblies", + "amphipathic", + "directly", + "h", + "z", + "sequences", "one", - "helices", - "barrels", - "novo", - "nonameric", + "interfaces", + "structures", + "de", "rational", - "peptides", - "nominally", - "residues", - "polar", - "hpphhph", - "residue", - "helix", - "water", - "varying", - "side", - "p" + "progress", + "oligomers", + "resulting", + "target", + "considerable", + "smaller", + "assemble", + "avoid", + "barrels", + "dimeric" ], "release_date":"2021-04-28", "publication":"\"Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states\", Chem Sci, 12, 6923-6928", @@ -404869,11 +406423,11 @@ }, { "sim":1.0, - "partner":"7nfk" + "partner":"6zt1" }, { "sim":1.0, - "partner":"6zt1" + "partner":"7nfk" }, { "sim":1.0, @@ -404959,6 +406513,10 @@ "sim":1.0, "partner":"6g69" }, + { + "sim":0.9901000261, + "partner":"6i1j" + }, { "sim":1.0, "partner":"7bo8" @@ -404967,10 +406525,6 @@ "sim":1.0, "partner":"7bo9" }, - { - "sim":0.9901000261, - "partner":"6i1j" - }, { "sim":0.9592000246, "partner":"5eze" @@ -405048,99 +406602,99 @@ ], "subtitle":"A hexameric barrel state of a de novo coiled-coil assembly: cc-type2-(ggiaid)4", "tags":[ - "barrel", - "alpha", "helical", "de novo protein", + "alpha", + "barrel", "hexamer" ], "keywords":[ - "amphipathic", - "oligomers", - "z", - "pentameric", - "must", - "discriminate", - "pattern", - "controllably", - "accessed", + "made", + "repeats", "allow", - "dimeric", - "smaller", - "crystal", - "target", + "hydrophobic", "show", - "sequences", + "glycine", "closer", - "however", - "alternative", - "expanding", - "contacts", - "direct", - "forces", - "interfaces", - "progressively", - "larger", - "unique", - "de", - "h", - "produce", + "pattern", + "side", + "accessed", + "short", + "residue", + "pentameric", "linear", - "nonetheless", - "point", - "hpphppp", + "helical", + "tetrameric", + "novo", + "controllably", + "hpphhph", + "crystal", + "predictably", + "weak", + "helices", + "chains", + "water", + "alternative", + "however", + "bundles", "decreasing", - "resulting", - "short", - "made", - "assemble", + "p", + "nonameric", + "residues", + "helix", "gives", - "structures", - "assembly", + "polar", + "progressively", + "contacts", + "sites", "size", - "alanine", - "predictably", - "considerable", - "directly", - "serine", - "assemblies", - "bundles", - "four", - "glycine", - "challenging", + "hpphppp", + "larger", + "nominally", + "threonine", "stabilize", + "four", + "serine", + "direct", "design", - "encode", - "avoid", - "helical", - "weak", + "challenging", + "must", + "discriminate", + "produce", + "assembly", + "alanine", + "point", + "forces", + "varying", + "rationalize", "states", - "hydrophobic", - "progress", "sequence", - "repeats", - "rationalize", - "threonine", - "tetrameric", - "sites", - "chains", + "peptides", + "encode", + "expanding", + "nonetheless", + "unique", + "assemblies", + "amphipathic", + "directly", + "h", + "z", + "sequences", "one", - "helices", - "barrels", - "novo", - "nonameric", + "interfaces", + "structures", + "de", "rational", - "peptides", - "nominally", - "residues", - "polar", - "hpphhph", - "residue", - "helix", - "water", - "varying", - "side", - "p" + "progress", + "oligomers", + "resulting", + "target", + "considerable", + "smaller", + "assemble", + "avoid", + "barrels", + "dimeric" ], "release_date":"2021-04-28", "publication":"\"Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states\", Chem Sci, 12, 6923-6928", @@ -405190,8 +406744,8 @@ "partner":"7a1t" }, { - "sim":0.9832999706, - "partner":"8b15" + "sim":1.0, + "partner":"8a09" }, { "sim":1.0, @@ -405199,19 +406753,15 @@ }, { "sim":1.0, - "partner":"8a09" + "partner":"8b16" }, { "sim":1.0, "partner":"4pn9" }, { - "sim":1.0, - "partner":"8b16" - }, - { - "sim":1.0, - "partner":"7bau" + "sim":0.9832999706, + "partner":"8b15" }, { "sim":0.9983000159, @@ -405219,23 +406769,11 @@ }, { "sim":1.0, - "partner":"6g69" - }, - { - "sim":0.994599998, - "partner":"7nfh" - }, - { - "sim":1.0, - "partner":"6xy1" - }, - { - "sim":0.9947999716, - "partner":"7nfo" + "partner":"7bau" }, { "sim":1.0, - "partner":"7nfj" + "partner":"6g6f" }, { "sim":0.9983000159, @@ -405246,8 +406784,8 @@ "partner":"6g6b" }, { - "sim":1.0, - "partner":"6g6f" + "sim":0.9983000159, + "partner":"7bav" }, { "sim":1.0, @@ -405257,6 +406795,10 @@ "sim":1.0, "partner":"5ez8" }, + { + "sim":1.0, + "partner":"7nfj" + }, { "sim":0.9947999716, "partner":"7nfk" @@ -405266,20 +406808,28 @@ "partner":"6g6d" }, { - "sim":0.9983000159, - "partner":"7bav" + "sim":1.0, + "partner":"6g69" + }, + { + "sim":0.994599998, + "partner":"7nfh" + }, + { + "sim":1.0, + "partner":"6xy1" }, { "sim":1.0, "partner":"5ezc" }, { - "sim":0.9987000227, - "partner":"7nfn" + "sim":0.9973999858, + "partner":"7bo9" }, { - "sim":0.996999979, - "partner":"6g68" + "sim":0.9947999716, + "partner":"7nfo" }, { "sim":1.0, @@ -405290,44 +406840,48 @@ "partner":"6eik" }, { - "sim":0.9563999772, - "partner":"5eze" + "sim":0.9987000227, + "partner":"7nfn" + }, + { + "sim":0.9983000159, + "partner":"7nfl" + }, + { + "sim":0.996999979, + "partner":"6g68" }, { "sim":0.9983999729, "partner":"6g6g" }, { - "sim":0.9983000159, - "partner":"7nfl" + "sim":0.9563999772, + "partner":"5eze" }, { - "sim":0.9973999858, - "partner":"7bo9" + "sim":0.9750000238, + "partner":"6yaz" }, { - "sim":1.0, - "partner":"6yb2" + "sim":0.9745000005, + "partner":"6yb0" }, { - "sim":0.9983000159, - "partner":"7nfg" + "sim":1.0, + "partner":"7bo8" }, { "sim":1.0, "partner":"6g6c" }, { - "sim":0.9973999858, - "partner":"7nff" - }, - { - "sim":0.9972000122, - "partner":"7nfm" + "sim":1.0, + "partner":"6yb2" }, { - "sim":0.9986000061, - "partner":"5eza" + "sim":0.9983000159, + "partner":"7nfg" }, { "sim":0.9848999977, @@ -405337,6 +406891,14 @@ "sim":1.0, "partner":"6g66" }, + { + "sim":0.9973999858, + "partner":"7nff" + }, + { + "sim":0.9972000122, + "partner":"7nfm" + }, { "sim":0.9933000207, "partner":"6g67" @@ -405346,40 +406908,36 @@ "partner":"7nfi" }, { - "sim":1.0, - "partner":"7bo8" + "sim":0.9986000061, + "partner":"5eza" + }, + { + "sim":0.9671999812, + "partner":"9gf2" }, { "sim":0.9983999729, "partner":"7boa" }, { - "sim":0.9697999954, - "partner":"8qae" + "sim":0.993900001, + "partner":"4dzk" }, { "sim":0.9764999747, "partner":"6xxz" }, { - "sim":0.9757000208, - "partner":"7nfp" - }, - { - "sim":0.9750000238, - "partner":"6yaz" - }, - { - "sim":0.9745000005, - "partner":"6yb0" + "sim":0.9624999762, + "partner":"6xy0" }, { - "sim":0.993900001, - "partner":"4dzk" + "sim":0.9697999954, + "partner":"8qae" }, { - "sim":0.9624999762, - "partner":"6xy0" + "sim":0.9757000208, + "partner":"7nfp" } ], "struct_thr_sim_natural":[ @@ -405451,99 +407009,99 @@ ], "subtitle":"A de novo pentameric coiled-coil assembly: cc-type2-(tgiaid)4-w19brphe", "tags":[ - "barrel", - "alpha", + "pentamer", "helical", "de novo protein", - "pentamer" + "alpha", + "barrel" ], "keywords":[ - "amphipathic", - "oligomers", - "z", - "pentameric", - "must", - "discriminate", - "pattern", - "controllably", - "accessed", + "made", + "repeats", "allow", - "dimeric", - "smaller", - "crystal", - "target", + "hydrophobic", "show", - "sequences", + "glycine", "closer", - "however", - "alternative", - "expanding", - "contacts", - "direct", - "forces", - "interfaces", - "progressively", - "larger", - "unique", - "de", - "h", - "produce", + "pattern", + "side", + "accessed", + "short", + "residue", + "pentameric", "linear", - "nonetheless", - "point", - "hpphppp", + "helical", + "tetrameric", + "novo", + "controllably", + "hpphhph", + "crystal", + "predictably", + "weak", + "helices", + "chains", + "water", + "alternative", + "however", + "bundles", "decreasing", - "resulting", - "short", - "made", - "assemble", + "p", + "nonameric", + "residues", + "helix", "gives", - "structures", - "assembly", + "polar", + "progressively", + "contacts", + "sites", "size", - "alanine", - "predictably", - "considerable", - "directly", - "serine", - "assemblies", - "bundles", - "four", - "glycine", - "challenging", + "hpphppp", + "larger", + "nominally", + "threonine", "stabilize", + "four", + "serine", + "direct", "design", - "encode", - "avoid", - "helical", - "weak", + "challenging", + "must", + "discriminate", + "produce", + "assembly", + "alanine", + "point", + "forces", + "varying", + "rationalize", "states", - "hydrophobic", - "progress", "sequence", - "repeats", - "rationalize", - "threonine", - "tetrameric", - "sites", - "chains", + "peptides", + "encode", + "expanding", + "nonetheless", + "unique", + "assemblies", + "amphipathic", + "directly", + "h", + "z", + "sequences", "one", - "helices", - "barrels", - "novo", - "nonameric", + "interfaces", + "structures", + "de", "rational", - "peptides", - "nominally", - "residues", - "polar", - "hpphhph", - "residue", - "helix", - "water", - "varying", - "side", - "p" + "progress", + "oligomers", + "resulting", + "target", + "considerable", + "smaller", + "assemble", + "avoid", + "barrels", + "dimeric" ], "release_date":"2021-04-28", "publication":"\"Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states\", Chem Sci, 12, 6923-6928", @@ -405580,141 +407138,125 @@ ], "struct_thr_sim_designed":[ - { - "sim":1.0, - "partner":"7bas" - }, { "sim":0.9943000078, "partner":"8b15" }, - { - "sim":0.9983000159, - "partner":"8b16" - }, { "sim":0.9983000159, "partner":"7bav" }, { - "sim":0.9983000159, - "partner":"8a09" + "sim":1.0, + "partner":"7bas" }, { - "sim":0.9954000115, - "partner":"4pn9" + "sim":0.9983000159, + "partner":"8b16" }, { "sim":0.9937000275, "partner":"6eiz" }, { - "sim":0.9952999949, - "partner":"7a1t" + "sim":0.9983000159, + "partner":"6g69" }, { - "sim":0.9984999895, - "partner":"7baw" + "sim":0.9954000115, + "partner":"4pn9" }, { - "sim":0.9937000275, - "partner":"7bat" + "sim":0.9983000159, + "partner":"6g68" }, { - "sim":1.0, - "partner":"7bim" + "sim":0.9951999784, + "partner":"6g6d" + }, + { + "sim":0.9952999949, + "partner":"7a1t" }, { "sim":0.9983000159, - "partner":"6g69" + "partner":"8a09" }, { - "sim":0.996999979, - "partner":"7bo9" + "sim":1.0, + "partner":"7nfh" }, { - "sim":0.9933999777, - "partner":"6g6a" + "sim":1.0, + "partner":"7nfo" }, { - "sim":0.9865999818, - "partner":"6g6b" + "sim":0.9965999722, + "partner":"6xy1" }, { - "sim":0.9983000159, - "partner":"6g6f" + "sim":0.9937000275, + "partner":"7bat" }, { - "sim":0.9951999784, - "partner":"6g6d" + "sim":0.9984999895, + "partner":"7baw" }, { - "sim":0.996900022, - "partner":"4pna" + "sim":1.0, + "partner":"7bim" }, { - "sim":0.9968000054, - "partner":"5ez8" + "sim":1.0, + "partner":"7bo8" }, { - "sim":0.9951999784, - "partner":"7nfj" + "sim":0.996999979, + "partner":"7bo9" }, { - "sim":0.9927999973, - "partner":"7nfk" + "sim":1.0, + "partner":"7boa" }, { - "sim":0.9965999722, - "partner":"6xy1" + "sim":0.9983000159, + "partner":"6g6f" }, { "sim":1.0, - "partner":"7nfh" + "partner":"6g6g" }, { "sim":1.0, - "partner":"7nfo" + "partner":"7nfg" }, { - "sim":0.9983000159, - "partner":"5ez9" + "sim":0.9933999777, + "partner":"6g6a" }, { - "sim":0.9937000275, - "partner":"5ezc" + "sim":0.9865999818, + "partner":"6g6b" }, { - "sim":0.9954000115, - "partner":"7nfn" + "sim":0.9984999895, + "partner":"6g6c" }, { "sim":0.9983000159, - "partner":"6g68" - }, - { - "sim":0.9937000275, - "partner":"6eik" + "partner":"6yb2" }, { - "sim":0.9905999899, - "partner":"6zt1" + "sim":0.9951999784, + "partner":"7nfj" }, { "sim":0.9968000054, "partner":"7nfl" }, { - "sim":1.0, - "partner":"7bo8" - }, - { - "sim":0.9509000182, - "partner":"5eze" - }, - { - "sim":1.0, - "partner":"6g6g" + "sim":0.9732000232, + "partner":"9gf2" }, { "sim":0.9835000038, @@ -405725,20 +407267,12 @@ "partner":"6yb0" }, { - "sim":1.0, - "partner":"7boa" - }, - { - "sim":0.9984999895, - "partner":"6g6c" - }, - { - "sim":0.9983000159, - "partner":"6yb2" + "sim":0.996900022, + "partner":"4pna" }, { - "sim":1.0, - "partner":"7nfg" + "sim":0.9968000054, + "partner":"5ez8" }, { "sim":0.9911999702, @@ -405765,21 +407299,49 @@ "partner":"7nfm" }, { - "sim":0.9950000048, - "partner":"4dzk" + "sim":0.9927999973, + "partner":"7nfk" }, { - "sim":0.9761999846, - "partner":"7nfp" + "sim":0.9983000159, + "partner":"5ez9" + }, + { + "sim":0.9937000275, + "partner":"5ezc" + }, + { + "sim":0.9954000115, + "partner":"7nfn" }, { "sim":0.9923999906, "partner":"4dzl" }, + { + "sim":0.9937000275, + "partner":"6eik" + }, + { + "sim":0.9905999899, + "partner":"6zt1" + }, + { + "sim":0.9761999846, + "partner":"7nfp" + }, { "sim":0.980700016, "partner":"7qdk" }, + { + "sim":0.9950000048, + "partner":"4dzk" + }, + { + "sim":0.9509000182, + "partner":"5eze" + }, { "sim":0.9674000144, "partner":"4dzn" @@ -405808,7 +407370,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"7bas" + "partner":"7nfh" }, "struct_max_sim_natural":[ @@ -405865,99 +407427,99 @@ ], "subtitle":"A de novo pentameric coiled-coil assembly: cc-type2-(tglaid)4-w19brphe", "tags":[ - "barrel", - "alpha", + "pentamer", "helical", "de novo protein", - "pentamer" + "alpha", + "barrel" ], "keywords":[ - "amphipathic", - "oligomers", - "z", - "pentameric", - "must", - "discriminate", - "pattern", - "controllably", - "accessed", + "made", + "repeats", "allow", - "dimeric", - "smaller", - "crystal", - "target", + "hydrophobic", "show", - "sequences", + "glycine", "closer", - "however", - "alternative", - "expanding", - "contacts", - "direct", - "forces", - "interfaces", - "progressively", - "larger", - "unique", - "de", - "h", - "produce", + "pattern", + "side", + "accessed", + "short", + "residue", + "pentameric", "linear", - "nonetheless", - "point", - "hpphppp", + "helical", + "tetrameric", + "novo", + "controllably", + "hpphhph", + "crystal", + "predictably", + "weak", + "helices", + "chains", + "water", + "alternative", + "however", + "bundles", "decreasing", - "resulting", - "short", - "made", - "assemble", + "p", + "nonameric", + "residues", + "helix", "gives", - "structures", - "assembly", + "polar", + "progressively", + "contacts", + "sites", "size", - "alanine", - "predictably", - "considerable", - "directly", - "serine", - "assemblies", - "bundles", - "four", - "glycine", - "challenging", + "hpphppp", + "larger", + "nominally", + "threonine", "stabilize", + "four", + "serine", + "direct", "design", - "encode", - "avoid", - "helical", - "weak", + "challenging", + "must", + "discriminate", + "produce", + "assembly", + "alanine", + "point", + "forces", + "varying", + "rationalize", "states", - "hydrophobic", - "progress", "sequence", - "repeats", - "rationalize", - "threonine", - "tetrameric", - "sites", - "chains", + "peptides", + "encode", + "expanding", + "nonetheless", + "unique", + "assemblies", + "amphipathic", + "directly", + "h", + "z", + "sequences", "one", - "helices", - "barrels", - "novo", - "nonameric", + "interfaces", + "structures", + "de", "rational", - "peptides", - "nominally", - "residues", - "polar", - "hpphhph", - "residue", - "helix", - "water", - "varying", - "side", - "p" + "progress", + "oligomers", + "resulting", + "target", + "considerable", + "smaller", + "assemble", + "avoid", + "barrels", + "dimeric" ], "release_date":"2021-04-28", "publication":"\"Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states\", Chem Sci, 12, 6923-6928", @@ -406042,18 +407604,10 @@ "sim":1.0, "partner":"7nfg" }, - { - "sim":1.0, - "partner":"7nff" - }, { "sim":1.0, "partner":"7nfj" }, - { - "sim":0.9758999944, - "partner":"7nfo" - }, { "sim":1.0, "partner":"5ez8" @@ -406066,6 +407620,10 @@ "sim":1.0, "partner":"6yb2" }, + { + "sim":1.0, + "partner":"7nff" + }, { "sim":1.0, "partner":"7nfi" @@ -406078,6 +407636,10 @@ "sim":1.0, "partner":"7nfm" }, + { + "sim":0.9758999944, + "partner":"7nfo" + }, { "sim":1.0, "partner":"7nfp" @@ -406102,6 +407664,10 @@ "sim":1.0, "partner":"6g6g" }, + { + "sim":0.996999979, + "partner":"7bat" + }, { "sim":1.0, "partner":"7baw" @@ -406114,10 +407680,6 @@ "sim":1.0, "partner":"5eza" }, - { - "sim":0.996999979, - "partner":"7bat" - }, { "sim":0.9743999839, "partner":"7nfh" @@ -406132,11 +407694,11 @@ }, { "sim":1.0, - "partner":"5ezc" + "partner":"6xxz" }, { "sim":1.0, - "partner":"6xxz" + "partner":"5ezc" }, { "sim":0.9769999981, @@ -406174,10 +407736,6 @@ "sim":1.0, "partner":"6g69" }, - { - "sim":0.9952999949, - "partner":"6i1j" - }, { "sim":1.0, "partner":"7bo8" @@ -406186,6 +407744,10 @@ "sim":1.0, "partner":"7bo9" }, + { + "sim":0.9952999949, + "partner":"6i1j" + }, { "sim":0.9805999994, "partner":"4dzl" @@ -406264,96 +407826,96 @@ "subtitle":"A heptameric barrel state of a de novo coiled-coil assembly: cc-type2-(ggiaid)4", "tags":[ "de novo protein", - "alpha-helical", - "barrel" + "barrel", + "alpha-helical" ], "keywords":[ - "amphipathic", - "oligomers", - "z", - "pentameric", - "must", - "discriminate", - "pattern", - "controllably", - "accessed", + "made", + "repeats", "allow", - "dimeric", - "smaller", - "crystal", - "target", + "hydrophobic", "show", - "sequences", + "glycine", "closer", - "however", - "alternative", - "expanding", - "contacts", - "direct", - "forces", - "interfaces", - "progressively", - "larger", - "unique", - "de", - "h", - "produce", + "pattern", + "side", + "accessed", + "short", + "residue", + "pentameric", "linear", - "nonetheless", - "point", - "hpphppp", + "helical", + "tetrameric", + "novo", + "controllably", + "hpphhph", + "crystal", + "predictably", + "weak", + "helices", + "chains", + "water", + "alternative", + "however", + "bundles", "decreasing", - "resulting", - "short", - "made", - "assemble", + "p", + "nonameric", + "residues", + "helix", "gives", - "structures", - "assembly", + "polar", + "progressively", + "contacts", + "sites", "size", - "alanine", - "predictably", - "considerable", - "directly", - "serine", - "assemblies", - "bundles", - "four", - "glycine", - "challenging", + "hpphppp", + "larger", + "nominally", + "threonine", "stabilize", + "four", + "serine", + "direct", "design", - "encode", - "avoid", - "helical", - "weak", + "challenging", + "must", + "discriminate", + "produce", + "assembly", + "alanine", + "point", + "forces", + "varying", + "rationalize", "states", - "hydrophobic", - "progress", "sequence", - "repeats", - "rationalize", - "threonine", - "tetrameric", - "sites", - "chains", + "peptides", + "encode", + "expanding", + "nonetheless", + "unique", + "assemblies", + "amphipathic", + "directly", + "h", + "z", + "sequences", "one", - "helices", - "barrels", - "novo", - "nonameric", + "interfaces", + "structures", + "de", "rational", - "peptides", - "nominally", - "residues", - "polar", - "hpphhph", - "residue", - "helix", - "water", - "varying", - "side", - "p" + "progress", + "oligomers", + "resulting", + "target", + "considerable", + "smaller", + "assemble", + "avoid", + "barrels", + "dimeric" ], "release_date":"2021-04-28", "publication":"\"Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states\", Chem Sci, 12, 6923-6928", @@ -406408,32 +407970,28 @@ }, { "sim":1.0, - "partner":"4pn9" + "partner":"6g68" }, { "sim":1.0, - "partner":"6eiz" + "partner":"6g69" }, { "sim":1.0, - "partner":"6g68" + "partner":"8b16" }, { "sim":1.0, - "partner":"6g69" + "partner":"4pn9" }, { "sim":1.0, - "partner":"8b16" + "partner":"6eiz" }, { "sim":1.0, "partner":"6g6d" }, - { - "sim":0.9947000146, - "partner":"8b15" - }, { "sim":1.0, "partner":"7bas" @@ -406450,6 +408008,10 @@ "sim":1.0, "partner":"4pna" }, + { + "sim":1.0, + "partner":"5ez8" + }, { "sim":0.9987000227, "partner":"6g65" @@ -406462,10 +408024,6 @@ "sim":0.9988999963, "partner":"6g6a" }, - { - "sim":0.9941999912, - "partner":"6g6b" - }, { "sim":1.0, "partner":"6g6c" @@ -406492,11 +408050,11 @@ }, { "sim":1.0, - "partner":"7nfg" + "partner":"7nfj" }, { "sim":1.0, - "partner":"7nfj" + "partner":"7nfl" }, { "sim":1.0, @@ -406504,23 +408062,23 @@ }, { "sim":1.0, - "partner":"5ez8" + "partner":"6g67" }, { - "sim":1.0, - "partner":"6g67" + "sim":0.9941999912, + "partner":"6g6b" }, { "sim":1.0, - "partner":"7nfh" + "partner":"7nfg" }, { "sim":1.0, - "partner":"7nfi" + "partner":"7nfh" }, { "sim":1.0, - "partner":"7nfl" + "partner":"7nfi" }, { "sim":1.0, @@ -406570,10 +408128,18 @@ "sim":0.9769999981, "partner":"6yb0" }, + { + "sim":0.9947000146, + "partner":"8b15" + }, { "sim":0.9607999921, "partner":"5eze" }, + { + "sim":0.9718000293, + "partner":"9gf2" + }, { "sim":1.0, "partner":"4dzk" @@ -406672,131 +408238,131 @@ ], "subtitle":"Het-n2-so3- - de novo designed three-helix heterodimer with cysteine s-sulfate at the n2 position of the alpha-helix", "tags":[ - "acyl transfer activity", "de novo protein", + "acyl transfer activity", "oxyanion-binding site", "domain swapped dimer" ], "keywords":[ - "results", - "critically", - "influences", - "catalysts", - "conjugation", - "acid", - "including", - "peptide", - "designed", - "prediction", - "robust", - "contains", - "principal", - "based", - "completion", - "position", - "\u03b1", - "represent", - "minimal", - "recently", - "oxidoreductases", - "applied", - "building", - "catalysis", - "starting", - "develop", - "junction", - "possesses", - "amide", - "proteins", - "unpaired", - "amidation", - "donors", - "de", - "enzymes", - "elements", - "minimalist", "negatively", - "point", - "efficient", - "goal", + "proved", + "stringent", + "structural", + "development", "number", - "small", - "motif", - "step", - "nucleophilic", "cavity", "project", - "charged", - "proved", - "showed", - "intermediates", - "first", - "second", - "thiol", - "outcome", - "reported", - "predefined", - "demonstrated", - "stringent", - "functional", - "amino", - "hydrolysis", + "donors", + "completion", + "rationally", + "hole", "group", + "acid", + "within", + "elements", + "results", + "residue", + "protein", + "restrictions", + "hydrolases", + "motif", + "showed", + "\u03b1", "acyl", - "report", - "others", + "charged", + "novo", + "site", "catalytic", - "artificial", + "oxyanion", + "adjacent", + "using", + "robust", + "chemistry", + "reaction", + "goal", + "conjugation", + "amidation", "reactions", - "restrictions", - "successful", + "starting", + "intermediates", + "step", + "influences", "specific", - "activity", - "transfer", - "concomitant", - "stabilize", - "introduced", - "design", - "nucleophile", - "rationally", - "bond", - "using", - "promising", - "exploited", - "formation", + "possesses", + "thiol", + "thioesters", + "oxidoreductases", "completely", - "structural", - "sites", - "hole", - "ligase", - "cysteine", - "chemistry", "approach", - "composition", - "novo", + "tetrahedral", + "proteins", + "sites", + "develop", + "unpaired", + "capable", + "concomitant", "acting", + "enzymes", + "contains", "labeling", - "sufficient", - "thioesters", + "small", + "bond", "emergence", - "momentum", - "reaction", - "capable", - "adjacent", - "hydrolases", - "gaining", - "set", - "protein", - "tetrahedral", - "residue", - "oxyanion", - "development", + "stabilize", + "introduced", "informatics", - "ligation", + "including", + "peptide", + "set", + "catalysts", + "design", + "critically", + "functional", + "represent", "environment", + "amide", + "ligation", + "cysteine", + "successful", + "prediction", + "point", + "gaining", + "amino", + "momentum", + "formation", + "promising", + "applied", + "building", + "reported", + "demonstrated", + "nucleophile", + "minimal", + "catalysis", + "designed", + "junction", + "ligase", + "efficient", + "others", + "de", + "principal", + "first", + "hydrolysis", + "based", + "predefined", + "report", + "recently", + "nucleophilic", + "artificial", "catalyzed", - "within", - "site" + "minimalist", + "activity", + "outcome", + "sufficient", + "composition", + "position", + "exploited", + "second", + "transfer" ], "release_date":"2021-03-17", "publication":"\"Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of alpha-Helix As Oxyanion-Binding Site\", J.Am.Chem.Soc., 143, 3330-3339", @@ -406915,67 +408481,67 @@ "synthetic construct" ], "keywords":[ - "stability", - "diverse", + "templates", + "repeats", "analysis", - "evolution", - "consisting", - "constraints", - "functional", - "proteins", - "large", - "reveals", - "architecture", - "multiple", - "unique", - "common", - "showing", - "study", - "formula", - "characterized", - "template", - "tools", - "artificial", - "fold", - "test", - "see", + "engineering", "engineered", + "design", + "characterized", + "perfectly", + "diverse", + "help", + "geometrical", "used", - "highly", - "approaches", - "useful", "suggests", + "functional", + "natural", + "multiple", + "approaches", + "based", + "permutation", + "consisting", + "discovered", + "fold", + "text", + "symmetrical", + "template", + "protein", "nature", + "useful", + "study", + "stability", + "showing", + "proteins", + "large", + "sequential", "symmetric", - "help", - "engineering", - "geometrical", + "artificial", + "tools", "systematic", + "architecture", + "see", + "constraints", "far", - "based", - "design", - "symmetrical", - "variation", - "protein", - "using", - "templates", - "natural", - "perfectly", - "discovered", - "describe", - "sequence", - "repeats", + "test", + "highly", "constraint", - "text", + "sequence", + "common", + "reveals", "circular", + "contain", + "created", + "evolution", + "formula", "monomer", - "computational", + "describe", "effects", - "could", - "permutation", - "sequential", - "contain", - "created" + "unique", + "variation", + "computational", + "using", + "could" ], "release_date":"2021-09-22", "publication":"\"Structure and stability of the designer protein WRAP-T and its permutants\", Sci Rep, 11, 18867-18867", @@ -407024,19 +408590,19 @@ }, { "sim":244.0, - "partner":"6g6n" + "partner":"6g6m" }, { "sim":244.0, - "partner":"6y7p" + "partner":"6y7n" }, { "sim":244.0, - "partner":"6y7n" + "partner":"6g6n" }, { "sim":244.0, - "partner":"6g6m" + "partner":"6y7p" }, { "sim":241.0, @@ -407074,15 +408640,15 @@ }, { "sim":193.0, - "partner":"2h9n" + "partner":"2o9k" }, { "sim":193.0, - "partner":"2o9k" + "partner":"2h9m" }, { "sim":193.0, - "partner":"2h9m" + "partner":"2h9n" }, { "sim":193.0, @@ -407102,51 +408668,47 @@ }, { "sim":192.0, - "partner":"6u8l" - }, - { - "sim":192.0, - "partner":"6u5m" + "partner":"6uj4" }, { "sim":192.0, - "partner":"6uhy" + "partner":"6uif" }, { "sim":192.0, - "partner":"6uoz" + "partner":"6u5y" }, { "sim":192.0, - "partner":"6uhz" + "partner":"6uik" }, { "sim":192.0, - "partner":"6uj4" + "partner":"6u8o" }, { "sim":192.0, - "partner":"6uif" + "partner":"6dy7" }, { "sim":192.0, - "partner":"6u5y" + "partner":"6u8l" }, { "sim":192.0, - "partner":"6uik" + "partner":"6u5m" }, { "sim":192.0, - "partner":"6u8o" + "partner":"6uhy" }, { "sim":192.0, - "partner":"6dy7" + "partner":"6uoz" }, { "sim":192.0, - "partner":"6pgf" + "partner":"6uhz" }, { "sim":192.0, @@ -407186,23 +408748,19 @@ }, { "sim":192.0, - "partner":"6iam" - }, - { - "sim":192.0, - "partner":"6byn" + "partner":"6pgf" }, { "sim":192.0, - "partner":"2g99" + "partner":"6iam" }, { "sim":192.0, - "partner":"5vfc" + "partner":"6byn" }, { "sim":192.0, - "partner":"6u6w" + "partner":"2g99" }, { "sim":192.0, @@ -407218,11 +408776,11 @@ }, { "sim":192.0, - "partner":"2h6k" + "partner":"6u6w" }, { "sim":192.0, - "partner":"5eap" + "partner":"5vfc" }, { "sim":192.0, @@ -407302,19 +408860,15 @@ }, { "sim":192.0, - "partner":"6ofz" - }, - { - "sim":192.0, - "partner":"6ujj" + "partner":"2h6k" }, { "sim":192.0, - "partner":"6e1y" + "partner":"5eap" }, { "sim":192.0, - "partner":"6ujl" + "partner":"6dai" }, { "sim":192.0, @@ -407322,11 +408876,11 @@ }, { "sim":192.0, - "partner":"6w5n" + "partner":"6pwv" }, { "sim":192.0, - "partner":"6dai" + "partner":"6dak" }, { "sim":192.0, @@ -407334,27 +408888,27 @@ }, { "sim":192.0, - "partner":"6pwv" + "partner":"6e22" }, { "sim":192.0, - "partner":"6dak" + "partner":"6wjq" }, { "sim":192.0, - "partner":"6e22" + "partner":"6e23" }, { "sim":192.0, - "partner":"6wjq" + "partner":"6oi0" }, { "sim":192.0, - "partner":"6e23" + "partner":"6oi1" }, { "sim":192.0, - "partner":"6oi0" + "partner":"6oi2" }, { "sim":192.0, @@ -407362,7 +408916,7 @@ }, { "sim":192.0, - "partner":"6oi1" + "partner":"6oi3" }, { "sim":192.0, @@ -407374,15 +408928,15 @@ }, { "sim":192.0, - "partner":"6oi2" + "partner":"6ujh" }, { "sim":192.0, - "partner":"6oi3" + "partner":"6pww" }, { "sim":192.0, - "partner":"6ujh" + "partner":"6dar" }, { "sim":192.0, @@ -407390,35 +408944,47 @@ }, { "sim":192.0, - "partner":"6pww" + "partner":"6das" }, { "sim":192.0, - "partner":"6dar" + "partner":"7dno" }, { "sim":192.0, - "partner":"6das" + "partner":"6w5m" }, { "sim":192.0, - "partner":"6w5m" + "partner":"6ucs" }, { "sim":192.0, - "partner":"7dno" + "partner":"6d9x" }, { "sim":192.0, - "partner":"6ucs" + "partner":"6w5i" }, { "sim":192.0, - "partner":"6d9x" + "partner":"6ofz" }, { "sim":192.0, - "partner":"6w5i" + "partner":"6ujj" + }, + { + "sim":192.0, + "partner":"6e1y" + }, + { + "sim":192.0, + "partner":"6ujl" + }, + { + "sim":192.0, + "partner":"6w5n" }, { "sim":192.0, @@ -407512,14 +409078,6 @@ "sim":192.0, "partner":"2h9l" }, - { - "sim":192.0, - "partner":"2xl3" - }, - { - "sim":192.0, - "partner":"7cfp" - }, { "sim":192.0, "partner":"6kiw" @@ -407548,6 +409106,14 @@ "sim":192.0, "partner":"6kix" }, + { + "sim":192.0, + "partner":"2xl3" + }, + { + "sim":192.0, + "partner":"7cfp" + }, { "sim":192.0, "partner":"2gnq" @@ -407564,6 +409130,10 @@ "sim":191.0, "partner":"3mxx" }, + { + "sim":185.0, + "partner":"8rl2" + }, { "sim":184.0, "partner":"7mt1" @@ -407576,10 +409146,6 @@ "sim":176.0, "partner":"4wjv" }, - { - "sim":176.0, - "partner":"7btb" - }, { "sim":176.0, "partner":"4v7f" @@ -407590,35 +409156,39 @@ }, { "sim":176.0, - "partner":"3jct" + "partner":"7bt6" }, { "sim":176.0, - "partner":"5jcs" + "partner":"6ft6" }, { "sim":176.0, - "partner":"7bt6" + "partner":"6ylh" }, { "sim":176.0, - "partner":"6ft6" + "partner":"3jct" }, { "sim":176.0, - "partner":"6ylh" + "partner":"5jcs" }, { "sim":176.0, "partner":"6m62" }, + { + "sim":176.0, + "partner":"6ylg" + }, { "sim":176.0, "partner":"4wju" }, { "sim":176.0, - "partner":"6ylg" + "partner":"7btb" }, { "sim":174.0, @@ -407634,35 +409204,31 @@ }, { "sim":162.0, - "partner":"7abi" + "partner":"6ff7" }, { "sim":162.0, "partner":"6ah0" }, - { - "sim":162.0, - "partner":"6ff7" - }, { "sim":162.0, "partner":"6ahd" }, { "sim":162.0, - "partner":"5xjc" + "partner":"6icz" }, { "sim":162.0, - "partner":"5z57" + "partner":"5xjc" }, { "sim":162.0, - "partner":"6icz" + "partner":"7abg" }, { "sim":162.0, - "partner":"7abg" + "partner":"5z57" }, { "sim":162.0, @@ -407674,19 +409240,23 @@ }, { "sim":162.0, - "partner":"5z56" + "partner":"7dvq" }, { "sim":162.0, "partner":"6qw6" }, + { + "sim":162.0, + "partner":"5z56" + }, { "sim":162.0, "partner":"5mqf" }, { "sim":162.0, - "partner":"7dvq" + "partner":"6qx9" }, { "sim":162.0, @@ -407698,15 +409268,15 @@ }, { "sim":162.0, - "partner":"6qx9" + "partner":"5z58" }, { "sim":162.0, - "partner":"5z58" + "partner":"6id1" }, { "sim":162.0, - "partner":"6id1" + "partner":"7abi" }, { "sim":161.0, @@ -407772,10 +409342,6 @@ "sim":147.0, "partner":"6gmh" }, - { - "sim":147.0, - "partner":"6olz" - }, { "sim":147.0, "partner":"6gz4" @@ -407798,7 +409364,7 @@ }, { "sim":147.0, - "partner":"6zol" + "partner":"6olz" }, { "sim":147.0, @@ -407812,6 +409378,10 @@ "sim":147.0, "partner":"6zoj" }, + { + "sim":147.0, + "partner":"6zol" + }, { "sim":147.0, "partner":"3ow8" @@ -407850,20 +409420,16 @@ }, { "sim":147.0, - "partner":"6t9k" + "partner":"6t9i" }, { "sim":147.0, - "partner":"6t9i" + "partner":"6t9k" }, { "sim":146.0, "partner":"6zvj" }, - { - "sim":146.0, - "partner":"6ole" - }, { "sim":146.0, "partner":"6om7" @@ -407882,28 +409448,12 @@ }, { "sim":146.0, - "partner":"6yam" - }, - { - "sim":146.0, - "partner":"6fec" - }, - { - "sim":146.0, - "partner":"6mtb" - }, - { - "sim":146.0, - "partner":"6zvh" + "partner":"6ole" }, { "sim":146.0, "partner":"3jaj" }, - { - "sim":146.0, - "partner":"8ukb" - }, { "sim":146.0, "partner":"6r6g" @@ -407918,11 +409468,11 @@ }, { "sim":146.0, - "partner":"3jai" + "partner":"6r6p" }, { "sim":146.0, - "partner":"6r6p" + "partner":"3jai" }, { "sim":146.0, @@ -407938,7 +409488,7 @@ }, { "sim":146.0, - "partner":"3jah" + "partner":"8ukb" }, { "sim":146.0, @@ -407948,6 +409498,10 @@ "sim":146.0, "partner":"6zvk" }, + { + "sim":146.0, + "partner":"3jah" + }, { "sim":146.0, "partner":"6r5q" @@ -407968,61 +409522,41 @@ "sim":146.0, "partner":"6mte" }, - { - "sim":146.0, - "partner":"3jag" - }, { "sim":146.0, "partner":"7a01" }, { "sim":146.0, - "partner":"3jan" - }, - { - "sim":146.0, - "partner":"7nwi" - }, - { - "sim":146.0, - "partner":"7nwh" - }, - { - "sim":146.0, - "partner":"5lzv" - }, - { - "sim":146.0, - "partner":"6zmw" + "partner":"3jag" }, { "sim":146.0, - "partner":"7jqc" + "partner":"6yam" }, { "sim":146.0, - "partner":"4kzx" + "partner":"7nwi" }, { "sim":146.0, - "partner":"6ip6" + "partner":"3jan" }, { "sim":146.0, - "partner":"6p5n" + "partner":"6fec" }, { "sim":146.0, - "partner":"6w2t" + "partner":"6mtb" }, { "sim":146.0, - "partner":"6zxg" + "partner":"6zvh" }, { "sim":146.0, - "partner":"6zmi" + "partner":"7nwh" }, { "sim":146.0, @@ -408034,11 +409568,7 @@ }, { "sim":146.0, - "partner":"7a09" - }, - { - "sim":146.0, - "partner":"7k5i" + "partner":"6p5j" }, { "sim":146.0, @@ -408052,29 +409582,17 @@ "sim":146.0, "partner":"5lzy" }, - { - "sim":146.0, - "partner":"3j7p" - }, - { - "sim":146.0, - "partner":"6p5j" - }, { "sim":146.0, "partner":"6zxh" }, { "sim":146.0, - "partner":"6hcf" - }, - { - "sim":146.0, - "partner":"3j7r" + "partner":"3j7p" }, { "sim":146.0, - "partner":"4kzz" + "partner":"6hcf" }, { "sim":146.0, @@ -408084,10 +409602,6 @@ "sim":146.0, "partner":"6zmo" }, - { - "sim":146.0, - "partner":"5vyc" - }, { "sim":146.0, "partner":"6p5k" @@ -408108,13 +409622,21 @@ "sim":146.0, "partner":"6zp4" }, + { + "sim":146.0, + "partner":"3j7r" + }, + { + "sim":146.0, + "partner":"4kzz" + }, { "sim":146.0, "partner":"7o7z" }, { "sim":146.0, - "partner":"5lzu" + "partner":"5vyc" }, { "sim":146.0, @@ -408130,11 +409652,7 @@ }, { "sim":146.0, - "partner":"5lks" - }, - { - "sim":146.0, - "partner":"5lzx" + "partner":"5lzu" }, { "sim":146.0, @@ -408142,7 +409660,7 @@ }, { "sim":146.0, - "partner":"8vft" + "partner":"5lks" }, { "sim":146.0, @@ -408158,11 +409676,7 @@ }, { "sim":146.0, - "partner":"4ujc" - }, - { - "sim":146.0, - "partner":"4v6x" + "partner":"5lzx" }, { "sim":146.0, @@ -408178,55 +409692,55 @@ }, { "sim":146.0, - "partner":"6zuo" + "partner":"4ujc" }, { "sim":146.0, - "partner":"5flx" + "partner":"4v6x" }, { "sim":146.0, - "partner":"6zv6" + "partner":"6zuo" }, { "sim":146.0, - "partner":"6zxd" + "partner":"6zv6" }, { "sim":146.0, - "partner":"7o7y" + "partner":"6zxd" }, { "sim":146.0, - "partner":"5lzt" + "partner":"6p5i" }, { "sim":146.0, - "partner":"6p5i" + "partner":"7o7y" }, { "sim":146.0, - "partner":"6d90" + "partner":"8vft" }, { "sim":146.0, - "partner":"6hcj" + "partner":"5flx" }, { "sim":146.0, - "partner":"6ip8" + "partner":"6d90" }, { "sim":146.0, - "partner":"4d61" + "partner":"6hcj" }, { "sim":146.0, - "partner":"5lzw" + "partner":"6ip8" }, { "sim":146.0, - "partner":"5t2c" + "partner":"5lzt" }, { "sim":146.0, @@ -408242,7 +409756,7 @@ }, { "sim":146.0, - "partner":"7o81" + "partner":"4d61" }, { "sim":146.0, @@ -408254,15 +409768,19 @@ }, { "sim":146.0, - "partner":"5aj0" + "partner":"7o81" }, { "sim":146.0, - "partner":"6g5i" + "partner":"5lzw" }, { "sim":146.0, - "partner":"4d5l" + "partner":"5t2c" + }, + { + "sim":146.0, + "partner":"6g5i" }, { "sim":146.0, @@ -408270,7 +409788,7 @@ }, { "sim":146.0, - "partner":"5lzz" + "partner":"5aj0" }, { "sim":146.0, @@ -408286,15 +409804,15 @@ }, { "sim":146.0, - "partner":"6p4h" + "partner":"4d5l" }, { "sim":146.0, - "partner":"4v5z" + "partner":"6p4h" }, { "sim":146.0, - "partner":"5lzs" + "partner":"5lzz" }, { "sim":146.0, @@ -408312,53 +409830,89 @@ "sim":146.0, "partner":"7mdz" }, + { + "sim":146.0, + "partner":"4v5z" + }, + { + "sim":146.0, + "partner":"5lzs" + }, + { + "sim":146.0, + "partner":"6zmw" + }, { "sim":146.0, "partner":"7o80" }, { "sim":146.0, - "partner":"4aow" + "partner":"6ip6" }, { "sim":146.0, - "partner":"1erj" + "partner":"6p5n" }, { - "sim":145.0, - "partner":"6xu7" + "sim":146.0, + "partner":"6w2t" }, { - "sim":145.0, - "partner":"6xu6" + "sim":146.0, + "partner":"6zxg" }, { - "sim":145.0, - "partner":"4v6w" + "sim":146.0, + "partner":"7jqc" }, { - "sim":145.0, - "partner":"6xu8" + "sim":146.0, + "partner":"5lzv" + }, + { + "sim":146.0, + "partner":"6zmi" + }, + { + "sim":146.0, + "partner":"4kzx" + }, + { + "sim":146.0, + "partner":"7a09" + }, + { + "sim":146.0, + "partner":"7k5i" + }, + { + "sim":146.0, + "partner":"4aow" + }, + { + "sim":146.0, + "partner":"1erj" }, { "sim":145.0, - "partner":"6f3t" + "partner":"6xu7" }, { "sim":145.0, - "partner":"7eg9" + "partner":"6xu6" }, { "sim":145.0, - "partner":"7enc" + "partner":"6xu8" }, { "sim":145.0, - "partner":"7egj" + "partner":"4v6w" }, { "sim":145.0, - "partner":"7ena" + "partner":"6f3t" }, { "sim":145.0, @@ -408405,84 +409959,84 @@ "partner":"7ege" }, { - "sim":144.0, - "partner":"7a1g" + "sim":145.0, + "partner":"7eg9" }, { - "sim":144.0, - "partner":"7b7d" + "sim":145.0, + "partner":"7enc" }, { - "sim":144.0, - "partner":"6tnu" + "sim":145.0, + "partner":"7egj" }, { - "sim":144.0, - "partner":"6t4q" + "sim":145.0, + "partner":"7ena" }, { "sim":144.0, - "partner":"6t7t" + "partner":"6tnu" }, { "sim":144.0, - "partner":"8ut0" + "partner":"6t4q" }, { "sim":144.0, - "partner":"6tb3" + "partner":"8uti" }, { "sim":144.0, - "partner":"7nrc" + "partner":"6t7t" }, { "sim":144.0, - "partner":"8uti" + "partner":"6tb3" }, { "sim":144.0, - "partner":"6i7o" + "partner":"7nrc" }, { "sim":144.0, - "partner":"4v7h" + "partner":"8ut0" }, { "sim":144.0, - "partner":"6zvi" + "partner":"7a1g" }, { "sim":144.0, - "partner":"7nrd" + "partner":"7b7d" }, { "sim":144.0, - "partner":"1trj" + "partner":"4v7h" }, { "sim":144.0, - "partner":"4v92" + "partner":"6zvi" }, { "sim":144.0, - "partner":"6wdr" + "partner":"7nrd" }, { "sim":144.0, - "partner":"4u4q" + "partner":"6i7o" }, { "sim":144.0, - "partner":"5obm" + "partner":"1trj" }, { "sim":144.0, - "partner":"4u4r" + "partner":"4v92" }, { "sim":144.0, - "partner":"5tgm" + "partner":"6wdr" }, { "sim":144.0, @@ -408498,27 +410052,27 @@ }, { "sim":144.0, - "partner":"6woo" + "partner":"4uer" }, { "sim":144.0, - "partner":"4uer" + "partner":"6gqv" }, { "sim":144.0, - "partner":"4u4u" + "partner":"6q8y" }, { "sim":144.0, - "partner":"5mei" + "partner":"4u4u" }, { "sim":144.0, - "partner":"6gqv" + "partner":"5mei" }, { "sim":144.0, - "partner":"6q8y" + "partner":"5tgm" }, { "sim":144.0, @@ -408540,6 +410094,10 @@ "sim":144.0, "partner":"5ndv" }, + { + "sim":144.0, + "partner":"6gq1" + }, { "sim":144.0, "partner":"5ndw" @@ -408554,7 +410112,7 @@ }, { "sim":144.0, - "partner":"6gq1" + "partner":"6gqb" }, { "sim":144.0, @@ -408568,10 +410126,6 @@ "sim":144.0, "partner":"5dgv" }, - { - "sim":144.0, - "partner":"6gqb" - }, { "sim":144.0, "partner":"4u50" @@ -408582,15 +410136,15 @@ }, { "sim":144.0, - "partner":"5tbw" + "partner":"6s47" }, { "sim":144.0, - "partner":"4u51" + "partner":"5tbw" }, { "sim":144.0, - "partner":"6s47" + "partner":"4u51" }, { "sim":144.0, @@ -408642,23 +410196,19 @@ }, { "sim":144.0, - "partner":"3j6y" - }, - { - "sim":144.0, - "partner":"4v8y" + "partner":"4u4q" }, { "sim":144.0, - "partner":"6zu9" + "partner":"5obm" }, { "sim":144.0, - "partner":"5juo" + "partner":"4u4r" }, { "sim":144.0, - "partner":"8t3f" + "partner":"6woo" }, { "sim":144.0, @@ -408670,11 +410220,11 @@ }, { "sim":144.0, - "partner":"5mc6" + "partner":"8t3f" }, { "sim":144.0, - "partner":"5jus" + "partner":"5mc6" }, { "sim":144.0, @@ -408682,47 +410232,47 @@ }, { "sim":144.0, - "partner":"8p4v" + "partner":"5jus" }, { "sim":144.0, - "partner":"8t2y" + "partner":"6t7i" }, { "sim":144.0, - "partner":"6t7i" + "partner":"6rbe" }, { "sim":144.0, - "partner":"8t3a" + "partner":"6t83" }, { "sim":144.0, - "partner":"6rbe" + "partner":"3j78" }, { "sim":144.0, - "partner":"6t83" + "partner":"8t2y" }, { "sim":144.0, - "partner":"8t30" + "partner":"3rfg" }, { "sim":144.0, - "partner":"3j78" + "partner":"5juu" }, { "sim":144.0, - "partner":"3rfg" + "partner":"6snt" }, { "sim":144.0, - "partner":"5juu" + "partner":"8t3a" }, { "sim":144.0, - "partner":"8t3c" + "partner":"8t30" }, { "sim":144.0, @@ -408734,15 +410284,19 @@ }, { "sim":144.0, - "partner":"6snt" + "partner":"8t3c" }, { "sim":144.0, - "partner":"8t3e" + "partner":"4v88" }, { "sim":144.0, - "partner":"4v88" + "partner":"6xir" + }, + { + "sim":144.0, + "partner":"8p4v" }, { "sim":144.0, @@ -408750,19 +410304,23 @@ }, { "sim":144.0, - "partner":"4v6i" + "partner":"6hhq" }, { "sim":144.0, - "partner":"5jup" + "partner":"8t3e" }, { "sim":144.0, - "partner":"6xir" + "partner":"4v6i" }, { "sim":144.0, - "partner":"6hhq" + "partner":"5jup" + }, + { + "sim":144.0, + "partner":"6sv4" }, { "sim":144.0, @@ -408770,7 +410328,7 @@ }, { "sim":144.0, - "partner":"8p9a" + "partner":"6z6k" }, { "sim":144.0, @@ -408778,7 +410336,7 @@ }, { "sim":144.0, - "partner":"6sv4" + "partner":"3j77" }, { "sim":144.0, @@ -408786,15 +410344,15 @@ }, { "sim":144.0, - "partner":"6z6k" + "partner":"5jut" }, { "sim":144.0, - "partner":"3j77" + "partner":"6fai" }, { "sim":144.0, - "partner":"5jut" + "partner":"6zu9" }, { "sim":144.0, @@ -408802,12 +410360,24 @@ }, { "sim":144.0, - "partner":"6fai" + "partner":"8p9a" + }, + { + "sim":144.0, + "partner":"3j6y" + }, + { + "sim":144.0, + "partner":"4v8y" }, { "sim":144.0, "partner":"8t3b" }, + { + "sim":144.0, + "partner":"5juo" + }, { "sim":144.0, "partner":"8t3d" @@ -408934,47 +410504,59 @@ }, { "sim":133.0, - "partner":"7f4h" + "partner":"8zfz" }, { "sim":133.0, - "partner":"7f9y" + "partner":"7f4d" }, { "sim":133.0, - "partner":"7f16" + "partner":"8vhf" }, { "sim":133.0, - "partner":"7dw9" + "partner":"7f9z" }, { "sim":133.0, - "partner":"7f4d" + "partner":"7f4i" }, { "sim":133.0, - "partner":"7f9z" + "partner":"7f4f" }, { "sim":133.0, - "partner":"7f4i" + "partner":"7d68" }, { "sim":133.0, - "partner":"7d68" + "partner":"7dty" }, { "sim":133.0, - "partner":"7f4f" + "partner":"7f4h" }, { "sim":133.0, - "partner":"8vhf" + "partner":"7f9y" }, { "sim":133.0, - "partner":"7dty" + "partner":"7f16" + }, + { + "sim":133.0, + "partner":"7dw9" + }, + { + "sim":133.0, + "partner":"8wwi" + }, + { + "sim":133.0, + "partner":"8wwj" }, { "sim":133.0, @@ -408998,15 +410580,11 @@ }, { "sim":133.0, - "partner":"8wwi" - }, - { - "sim":133.0, - "partner":"8wwj" + "partner":"6vn7" }, { "sim":133.0, - "partner":"6vn7" + "partner":"8jsr" }, { "sim":133.0, @@ -409038,19 +410616,7 @@ }, { "sim":132.0, - "partner":"5ukk" - }, - { - "sim":132.0, - "partner":"7dfl" - }, - { - "sim":132.0, - "partner":"7k7z" - }, - { - "sim":132.0, - "partner":"7jjo" + "partner":"8wgb" }, { "sim":132.0, @@ -409078,39 +410644,39 @@ }, { "sim":132.0, - "partner":"5he2" + "partner":"6g79" }, { "sim":132.0, - "partner":"6g79" + "partner":"5he2" }, { "sim":132.0, - "partner":"8wgb" + "partner":"5he3" }, { "sim":132.0, - "partner":"5he3" + "partner":"7dfl" }, { "sim":132.0, - "partner":"6wi9" + "partner":"5ukk" }, { "sim":132.0, - "partner":"7o7f" + "partner":"7k7z" }, { "sim":132.0, - "partner":"4kfm" + "partner":"7jjo" }, { "sim":132.0, - "partner":"6x18" + "partner":"7dhr" }, { "sim":132.0, - "partner":"1got" + "partner":"8k4s" }, { "sim":132.0, @@ -409122,23 +410688,23 @@ }, { "sim":132.0, - "partner":"7dhr" + "partner":"6pcv" }, { "sim":132.0, - "partner":"3v5w" + "partner":"6vms" }, { "sim":132.0, - "partner":"6pcv" + "partner":"6x19" }, { "sim":132.0, - "partner":"6vms" + "partner":"1got" }, { "sim":132.0, - "partner":"6x19" + "partner":"3v5w" }, { "sim":132.0, @@ -409146,11 +410712,11 @@ }, { "sim":132.0, - "partner":"6niy" + "partner":"8p15" }, { "sim":132.0, - "partner":"6x1a" + "partner":"6niy" }, { "sim":132.0, @@ -409158,11 +410724,11 @@ }, { "sim":132.0, - "partner":"7lci" + "partner":"8vve" }, { "sim":132.0, - "partner":"8k4s" + "partner":"6x1a" }, { "sim":132.0, @@ -409170,63 +410736,63 @@ }, { "sim":132.0, - "partner":"7ki0" + "partner":"7lci" }, { "sim":132.0, - "partner":"1gg2" + "partner":"7f1r" }, { "sim":132.0, - "partner":"3pvu" + "partner":"8vvf" }, { "sim":132.0, - "partner":"4pnk" + "partner":"6c2y" }, { "sim":132.0, - "partner":"6c2y" + "partner":"7ki0" }, { "sim":132.0, - "partner":"7f1r" + "partner":"6kpf" }, { "sim":132.0, - "partner":"8p12" + "partner":"8zjg" }, { "sim":132.0, - "partner":"3ah8" + "partner":"3pvu" }, { "sim":132.0, - "partner":"3uzs" + "partner":"4pnk" }, { "sim":132.0, - "partner":"6kpf" + "partner":"7bz2" }, { "sim":132.0, - "partner":"1b9x" + "partner":"7f1s" }, { "sim":132.0, - "partner":"2bcj" + "partner":"3ah8" }, { "sim":132.0, - "partner":"7bz2" + "partner":"3uzs" }, { "sim":132.0, - "partner":"1gp2" + "partner":"7dhi" }, { "sim":132.0, - "partner":"5wg3" + "partner":"2bcj" }, { "sim":132.0, @@ -409234,27 +410800,35 @@ }, { "sim":132.0, - "partner":"7dhi" + "partner":"8vvg" }, { "sim":132.0, - "partner":"7f1s" + "partner":"1gg2" }, { "sim":132.0, - "partner":"1b9y" + "partner":"5wg3" }, { "sim":132.0, - "partner":"3psc" + "partner":"7ki1" }, { "sim":132.0, - "partner":"7ki1" + "partner":"7mbx" }, { "sim":132.0, - "partner":"7mbx" + "partner":"1b9x" + }, + { + "sim":132.0, + "partner":"3psc" + }, + { + "sim":132.0, + "partner":"6wzg" }, { "sim":132.0, @@ -409266,7 +410840,7 @@ }, { "sim":132.0, - "partner":"8p13" + "partner":"1gp2" }, { "sim":132.0, @@ -409278,11 +410852,7 @@ }, { "sim":132.0, - "partner":"6wzg" - }, - { - "sim":132.0, - "partner":"1a0r" + "partner":"1b9y" }, { "sim":132.0, @@ -409294,11 +410864,11 @@ }, { "sim":132.0, - "partner":"3krw" + "partner":"6qno" }, { "sim":132.0, - "partner":"5wg5" + "partner":"6rmv" }, { "sim":132.0, @@ -409310,15 +410880,23 @@ }, { "sim":132.0, - "partner":"6qno" + "partner":"8p12" }, { "sim":132.0, - "partner":"6rmv" + "partner":"8xqe" }, { "sim":132.0, - "partner":"3krx" + "partner":"3krw" + }, + { + "sim":132.0, + "partner":"5wg5" + }, + { + "sim":132.0, + "partner":"1a0r" }, { "sim":132.0, @@ -409326,7 +410904,11 @@ }, { "sim":132.0, - "partner":"8p15" + "partner":"8z7j" + }, + { + "sim":132.0, + "partner":"3krx" }, { "sim":132.0, @@ -409334,7 +410916,27 @@ }, { "sim":132.0, - "partner":"6m1h" + "partner":"6wi9" + }, + { + "sim":132.0, + "partner":"6x18" + }, + { + "sim":132.0, + "partner":"7o7f" + }, + { + "sim":132.0, + "partner":"8p13" + }, + { + "sim":132.0, + "partner":"8xqf" + }, + { + "sim":132.0, + "partner":"4kfm" }, { "sim":132.0, @@ -409342,11 +410944,11 @@ }, { "sim":132.0, - "partner":"5tdh" + "partner":"6m1h" }, { "sim":132.0, - "partner":"6xbk" + "partner":"5tdh" }, { "sim":132.0, @@ -409370,11 +410972,11 @@ }, { "sim":132.0, - "partner":"6dde" + "partner":"7db6" }, { "sim":132.0, - "partner":"7db6" + "partner":"6dde" }, { "sim":132.0, @@ -409386,28 +410988,16 @@ }, { "sim":132.0, - "partner":"6nbi" - }, - { - "sim":132.0, - "partner":"6oij" - }, - { - "sim":132.0, - "partner":"7duq" + "partner":"6xbk" }, { "sim":132.0, - "partner":"7e32" + "partner":"7dur" }, { "sim":132.0, "partner":"6oik" }, - { - "sim":132.0, - "partner":"7dur" - }, { "sim":132.0, "partner":"7e33" @@ -409420,6 +411010,10 @@ "sim":132.0, "partner":"7evm" }, + { + "sim":132.0, + "partner":"7e2x" + }, { "sim":132.0, "partner":"7jhj" @@ -409434,15 +411028,15 @@ }, { "sim":132.0, - "partner":"7e2x" + "partner":"7cmu" }, { "sim":132.0, - "partner":"6pb0" + "partner":"7e2y" }, { "sim":132.0, - "partner":"7cmu" + "partner":"6pb0" }, { "sim":132.0, @@ -409450,11 +411044,11 @@ }, { "sim":132.0, - "partner":"7e2y" + "partner":"7exd" }, { "sim":132.0, - "partner":"7exd" + "partner":"7e14" }, { "sim":132.0, @@ -409462,7 +411056,7 @@ }, { "sim":132.0, - "partner":"7e14" + "partner":"7e2z" }, { "sim":132.0, @@ -409470,15 +411064,27 @@ }, { "sim":132.0, - "partner":"7e2z" + "partner":"6pb1" }, { "sim":132.0, - "partner":"6pb1" + "partner":"6crk" }, { "sim":132.0, - "partner":"6crk" + "partner":"6nbi" + }, + { + "sim":132.0, + "partner":"7duq" + }, + { + "sim":132.0, + "partner":"7e32" + }, + { + "sim":132.0, + "partner":"6oij" }, { "sim":132.0, @@ -409514,47 +411120,43 @@ }, { "sim":132.0, - "partner":"6d9h" - }, - { - "sim":132.0, - "partner":"6p9x" + "partner":"6vcb" }, { "sim":132.0, - "partner":"6uva" + "partner":"7joz" }, { "sim":132.0, - "partner":"6k42" + "partner":"6p9y" }, { "sim":132.0, - "partner":"6xox" + "partner":"8xx3" }, { "sim":132.0, - "partner":"6vcb" + "partner":"5ukm" }, { "sim":132.0, - "partner":"7joz" + "partner":"6e3y" }, { "sim":132.0, - "partner":"5ukm" + "partner":"7ld3" }, { "sim":132.0, - "partner":"6p9y" + "partner":"6m8s" }, { "sim":132.0, - "partner":"7ld3" + "partner":"6ni3" }, { "sim":132.0, - "partner":"6e3y" + "partner":"7c2e" }, { "sim":132.0, @@ -409562,15 +411164,15 @@ }, { "sim":132.0, - "partner":"6m8s" + "partner":"8xx7" }, { "sim":132.0, - "partner":"6ni3" + "partner":"8xwv" }, { "sim":132.0, - "partner":"7c2e" + "partner":"8xxh" }, { "sim":132.0, @@ -409584,13 +411186,21 @@ "sim":132.0, "partner":"6orv" }, + { + "sim":132.0, + "partner":"8tyw" + }, { "sim":132.0, "partner":"6uus" }, { "sim":132.0, - "partner":"8tyw" + "partner":"8jzp" + }, + { + "sim":132.0, + "partner":"8xxx" }, { "sim":132.0, @@ -409598,7 +411208,31 @@ }, { "sim":132.0, - "partner":"7e9h" + "partner":"8xxr" + }, + { + "sim":132.0, + "partner":"6d9h" + }, + { + "sim":132.0, + "partner":"6p9x" + }, + { + "sim":132.0, + "partner":"6uva" + }, + { + "sim":132.0, + "partner":"8xx6" + }, + { + "sim":132.0, + "partner":"6k42" + }, + { + "sim":132.0, + "partner":"6xox" }, { "sim":132.0, @@ -409638,15 +411272,15 @@ }, { "sim":132.0, - "partner":"3sn6" + "partner":"7e9g" }, { "sim":132.0, - "partner":"7e9g" + "partner":"7ezm" }, { "sim":132.0, - "partner":"7ezm" + "partner":"3sn6" }, { "sim":132.0, @@ -409656,6 +411290,10 @@ "sim":132.0, "partner":"6ot0" }, + { + "sim":132.0, + "partner":"7e9h" + }, { "sim":132.0, "partner":"7ljc" @@ -409674,15 +411312,15 @@ }, { "sim":132.0, - "partner":"7ckx" + "partner":"8x3l" }, { "sim":132.0, - "partner":"7crh" + "partner":"7ckx" }, { "sim":132.0, - "partner":"8x3l" + "partner":"7crh" }, { "sim":132.0, @@ -409692,21 +411330,17 @@ "sim":132.0, "partner":"7aue" }, - { - "sim":132.0, - "partner":"7cx2" - }, { "sim":132.0, "partner":"6wpw" }, { "sim":132.0, - "partner":"8rql" + "partner":"7cx3" }, { "sim":132.0, - "partner":"7cx3" + "partner":"8rql" }, { "sim":132.0, @@ -409730,7 +411364,7 @@ }, { "sim":132.0, - "partner":"7l0r" + "partner":"7cx2" }, { "sim":132.0, @@ -409746,15 +411380,15 @@ }, { "sim":132.0, - "partner":"7bb6" + "partner":"7l0r" }, { "sim":132.0, - "partner":"7bb7" + "partner":"7bb6" }, { - "sim":129.0, - "partner":"4v5o" + "sim":132.0, + "partner":"7bb7" }, { "sim":129.0, @@ -409762,7 +411396,7 @@ }, { "sim":129.0, - "partner":"6m90" + "partner":"4v5o" }, { "sim":129.0, @@ -409780,6 +411414,10 @@ "sim":129.0, "partner":"6m94" }, + { + "sim":129.0, + "partner":"6m90" + }, { "sim":129.0, "partner":"1p22" @@ -409830,35 +411468,35 @@ }, { "sim":128.0, - "partner":"3jam" + "partner":"6fyx" }, { "sim":128.0, - "partner":"3jap" + "partner":"6uz7" }, { "sim":128.0, - "partner":"6fyy" + "partner":"3j80" }, { "sim":128.0, - "partner":"3j80" + "partner":"3j81" }, { "sim":128.0, - "partner":"6fyx" + "partner":"8s8k" }, { "sim":128.0, - "partner":"6uz7" + "partner":"3jam" }, { "sim":128.0, - "partner":"3j81" + "partner":"3jap" }, { "sim":128.0, - "partner":"8s8k" + "partner":"6fyy" }, { "sim":128.0, @@ -409868,10 +411506,6 @@ "sim":128.0, "partner":"3jb9" }, - { - "sim":126.0, - "partner":"6rxy" - }, { "sim":126.0, "partner":"5oql" @@ -409897,16 +411531,8 @@ "partner":"6rxt" }, { - "sim":125.0, - "partner":"6ke6" - }, - { - "sim":125.0, - "partner":"6lqq" - }, - { - "sim":125.0, - "partner":"7ajt" + "sim":126.0, + "partner":"6rxy" }, { "sim":125.0, @@ -409968,6 +411594,18 @@ "sim":125.0, "partner":"6lqp" }, + { + "sim":125.0, + "partner":"6ke6" + }, + { + "sim":125.0, + "partner":"6lqq" + }, + { + "sim":125.0, + "partner":"7ajt" + }, { "sim":124.0, "partner":"8r8b" @@ -410088,10 +411726,6 @@ "sim":120.0, "partner":"7dco" }, - { - "sim":120.0, - "partner":"7b9v" - }, { "sim":120.0, "partner":"6bk8" @@ -410102,11 +411736,11 @@ }, { "sim":120.0, - "partner":"5wsg" + "partner":"6j6q" }, { "sim":120.0, - "partner":"6j6q" + "partner":"5wsg" }, { "sim":120.0, @@ -410120,6 +411754,10 @@ "sim":120.0, "partner":"5y88" }, + { + "sim":120.0, + "partner":"6j6g" + }, { "sim":120.0, "partner":"5gm6" @@ -410130,7 +411768,7 @@ }, { "sim":120.0, - "partner":"6j6g" + "partner":"6j6n" }, { "sim":120.0, @@ -410138,23 +411776,23 @@ }, { "sim":120.0, - "partner":"6j6n" + "partner":"5lqw" }, { "sim":120.0, - "partner":"5lqw" + "partner":"6j6h" }, { "sim":120.0, - "partner":"5mps" + "partner":"7b9v" }, { "sim":120.0, - "partner":"5ylz" + "partner":"5mps" }, { "sim":120.0, - "partner":"6j6h" + "partner":"5ylz" }, { "sim":117.0, @@ -410250,15 +411888,15 @@ }, { "sim":101.0, - "partner":"7ay2" + "partner":"5k1c" }, { "sim":101.0, - "partner":"5k1c" + "partner":"7ay0" }, { "sim":101.0, - "partner":"7ay0" + "partner":"7ay2" }, { "sim":101.0, @@ -410318,11 +411956,11 @@ }, { "sim":96.0, - "partner":"1pev" + "partner":"1nr0" }, { "sim":96.0, - "partner":"1nr0" + "partner":"1pev" }, { "sim":94.0, @@ -410350,43 +411988,43 @@ }, { "sim":92.0, - "partner":"3mzk" + "partner":"3mzl" }, { "sim":92.0, - "partner":"6zg5" + "partner":"6zg6" }, { "sim":92.0, - "partner":"4xmm" + "partner":"3iko" }, { "sim":92.0, - "partner":"3mzl" + "partner":"4xmn" }, { "sim":92.0, - "partner":"3iko" + "partner":"2pm6" }, { "sim":92.0, - "partner":"6zg6" + "partner":"6zl0" }, { "sim":92.0, - "partner":"4xmn" + "partner":"4bzk" }, { "sim":92.0, - "partner":"2pm6" + "partner":"6zg5" }, { "sim":92.0, - "partner":"6zl0" + "partner":"3mzk" }, { "sim":92.0, - "partner":"4bzk" + "partner":"4xmm" }, { "sim":92.0, @@ -410410,11 +412048,11 @@ }, { "sim":90.0, - "partner":"6uh5" + "partner":"6ugm" }, { "sim":90.0, - "partner":"6ugm" + "partner":"6uh5" }, { "sim":89.0, @@ -410470,27 +412108,23 @@ }, { "sim":84.0, - "partner":"2xu7" - }, - { - "sim":84.0, - "partner":"7ktp" + "partner":"6g16" }, { "sim":84.0, - "partner":"6g16" + "partner":"7aoa" }, { "sim":84.0, - "partner":"5fxy" + "partner":"8vml" }, { "sim":84.0, - "partner":"7aoa" + "partner":"6c24" }, { "sim":84.0, - "partner":"6c24" + "partner":"5fxy" }, { "sim":84.0, @@ -410504,18 +412138,26 @@ "sim":84.0, "partner":"4pby" }, + { + "sim":84.0, + "partner":"8vmi" + }, { "sim":84.0, "partner":"4pbz" }, { "sim":84.0, - "partner":"4pc0" + "partner":"8vnv" }, { "sim":84.0, "partner":"7ksr" }, + { + "sim":84.0, + "partner":"4pc0" + }, { "sim":84.0, "partner":"6c23" @@ -410524,13 +412166,25 @@ "sim":84.0, "partner":"7kso" }, + { + "sim":84.0, + "partner":"6zrd" + }, + { + "sim":84.0, + "partner":"8vnz" + }, { "sim":84.0, "partner":"3gfc" }, { "sim":84.0, - "partner":"6zrd" + "partner":"2xu7" + }, + { + "sim":84.0, + "partner":"7ktp" }, { "sim":84.0, @@ -410548,10 +412202,6 @@ "sim":84.0, "partner":"5vtb" }, - { - "sim":84.0, - "partner":"6nq3" - }, { "sim":84.0, "partner":"5wai" @@ -410562,7 +412212,7 @@ }, { "sim":84.0, - "partner":"5xwr" + "partner":"6nq3" }, { "sim":84.0, @@ -410570,16 +412220,20 @@ }, { "sim":84.0, - "partner":"8tx8" + "partner":"5xwr" }, { "sim":84.0, - "partner":"5xxq" + "partner":"8tx8" }, { "sim":84.0, "partner":"5y1u" }, + { + "sim":84.0, + "partner":"5xxq" + }, { "sim":80.0, "partner":"6lk8" @@ -410606,11 +412260,11 @@ }, { "sim":75.0, - "partner":"5vh9" + "partner":"5vlj" }, { "sim":75.0, - "partner":"5vlj" + "partner":"5vh9" }, { "sim":74.0, @@ -410646,11 +412300,11 @@ }, { "sim":70.0, - "partner":"5m2n" + "partner":"6qk7" }, { "sim":70.0, - "partner":"6qk7" + "partner":"5m2n" }, { "sim":70.0, @@ -410742,15 +412396,15 @@ }, { "sim":67.0, - "partner":"3f3g" + "partner":"3f3p" }, { "sim":67.0, - "partner":"3f3p" + "partner":"3f3f" }, { "sim":67.0, - "partner":"3f3f" + "partner":"3f3g" }, { "sim":67.0, @@ -410792,14 +412446,6 @@ "sim":66.0, "partner":"6r92" }, - { - "sim":66.0, - "partner":"5m5g" - }, - { - "sim":66.0, - "partner":"5wfd" - }, { "sim":66.0, "partner":"5bjs" @@ -410832,6 +412478,14 @@ "sim":66.0, "partner":"5wfc" }, + { + "sim":66.0, + "partner":"5m5g" + }, + { + "sim":66.0, + "partner":"5wfd" + }, { "sim":64.0, "partner":"5cyk" @@ -410850,35 +412504,35 @@ }, { "sim":62.0, - "partner":"6qtv" + "partner":"6qto" }, { "sim":62.0, - "partner":"6qtw" + "partner":"6qtq" }, { "sim":62.0, - "partner":"6qtx" + "partner":"6qtr" }, { "sim":62.0, - "partner":"6qto" + "partner":"6qtt" }, { "sim":62.0, - "partner":"6qtq" + "partner":"6qtu" }, { "sim":62.0, - "partner":"6qtr" + "partner":"6qtv" }, { "sim":62.0, - "partner":"6qtt" + "partner":"6qtw" }, { "sim":62.0, - "partner":"6qtu" + "partner":"6qtx" }, { "sim":62.0, @@ -410926,19 +412580,19 @@ }, { "sim":57.0, - "partner":"2aq5" + "partner":"2b4e" }, { "sim":57.0, - "partner":"2b4e" + "partner":"2aq5" }, { "sim":56.0, - "partner":"7m05" + "partner":"6v0n" }, { "sim":56.0, - "partner":"6v0n" + "partner":"7m05" }, { "sim":56.0, @@ -410966,63 +412620,63 @@ }, { "sim":56.0, - "partner":"4x63" + "partner":"4x60" }, { "sim":56.0, - "partner":"7kid" + "partner":"4x61" }, { "sim":56.0, - "partner":"6uxx" + "partner":"5c9z" }, { "sim":56.0, - "partner":"6uxy" + "partner":"5emj" }, { "sim":56.0, - "partner":"4x60" + "partner":"6k1s" }, { "sim":56.0, - "partner":"4x61" + "partner":"7l1g" }, { "sim":56.0, - "partner":"5c9z" + "partner":"5emk" }, { "sim":56.0, - "partner":"5emj" + "partner":"5eml" }, { "sim":56.0, - "partner":"5emk" + "partner":"7kib" }, { "sim":56.0, - "partner":"6k1s" + "partner":"5emm" }, { "sim":56.0, - "partner":"7l1g" + "partner":"7kic" }, { "sim":56.0, - "partner":"5eml" + "partner":"6uxx" }, { "sim":56.0, - "partner":"7kib" + "partner":"7kid" }, { "sim":56.0, - "partner":"5emm" + "partner":"4x63" }, { "sim":56.0, - "partner":"7kic" + "partner":"6uxy" }, { "sim":56.0, @@ -411130,67 +412784,67 @@ "synthetic construct" ], "keywords":[ - "stability", - "diverse", + "templates", + "repeats", "analysis", - "evolution", - "consisting", - "constraints", - "functional", - "proteins", - "large", - "reveals", - "architecture", - "multiple", - "unique", - "common", - "showing", - "study", - "formula", - "characterized", - "template", - "tools", - "artificial", - "fold", - "test", - "see", + "engineering", "engineered", + "design", + "characterized", + "perfectly", + "diverse", + "help", + "geometrical", "used", - "highly", - "approaches", - "useful", "suggests", + "functional", + "natural", + "multiple", + "approaches", + "based", + "permutation", + "consisting", + "discovered", + "fold", + "text", + "symmetrical", + "template", + "protein", "nature", + "useful", + "study", + "stability", + "showing", + "proteins", + "large", + "sequential", "symmetric", - "help", - "engineering", - "geometrical", + "artificial", + "tools", "systematic", + "architecture", + "see", + "constraints", "far", - "based", - "design", - "symmetrical", - "variation", - "protein", - "using", - "templates", - "natural", - "perfectly", - "discovered", - "describe", - "sequence", - "repeats", + "test", + "highly", "constraint", - "text", + "sequence", + "common", + "reveals", "circular", + "contain", + "created", + "evolution", + "formula", "monomer", - "computational", + "describe", "effects", - "could", - "permutation", - "sequential", - "contain", - "created" + "unique", + "variation", + "computational", + "using", + "could" ], "release_date":"2021-09-22", "publication":"\"Structure and stability of the designer protein WRAP-T and its permutants\", Sci Rep, 11, 18867-18867", @@ -411235,19 +412889,19 @@ }, { "sim":266.0, - "partner":"6g6n" + "partner":"6g6m" }, { "sim":266.0, - "partner":"6y7p" + "partner":"6y7n" }, { "sim":266.0, - "partner":"6y7n" + "partner":"6g6n" }, { "sim":266.0, - "partner":"6g6m" + "partner":"6y7p" }, { "sim":265.0, @@ -411279,6 +412933,10 @@ "sim":229.0, "partner":"5yzv" }, + { + "sim":221.0, + "partner":"8rl2" + }, { "sim":219.0, "partner":"5nnz" @@ -411291,14 +412949,6 @@ "sim":209.0, "partner":"6dya" }, - { - "sim":209.0, - "partner":"5vfc" - }, - { - "sim":209.0, - "partner":"6u6w" - }, { "sim":209.0, "partner":"6u8b" @@ -411309,11 +412959,11 @@ }, { "sim":209.0, - "partner":"2h6k" + "partner":"6u6w" }, { "sim":209.0, - "partner":"5eap" + "partner":"5vfc" }, { "sim":209.0, @@ -411393,23 +413043,15 @@ }, { "sim":209.0, - "partner":"2h9n" - }, - { - "sim":209.0, - "partner":"6ofz" - }, - { - "sim":209.0, - "partner":"6ujj" + "partner":"2h6k" }, { "sim":209.0, - "partner":"6e1y" + "partner":"5eap" }, { "sim":209.0, - "partner":"6ujl" + "partner":"6dai" }, { "sim":209.0, @@ -411417,11 +413059,11 @@ }, { "sim":209.0, - "partner":"6w5n" + "partner":"6pwv" }, { "sim":209.0, - "partner":"6dai" + "partner":"6dak" }, { "sim":209.0, @@ -411429,27 +413071,27 @@ }, { "sim":209.0, - "partner":"6pwv" + "partner":"6e22" }, { "sim":209.0, - "partner":"6dak" + "partner":"6wjq" }, { "sim":209.0, - "partner":"6e22" + "partner":"6e23" }, { "sim":209.0, - "partner":"6wjq" + "partner":"6oi0" }, { "sim":209.0, - "partner":"6e23" + "partner":"6oi1" }, { "sim":209.0, - "partner":"6oi0" + "partner":"6oi2" }, { "sim":209.0, @@ -411457,7 +413099,7 @@ }, { "sim":209.0, - "partner":"6oi1" + "partner":"6oi3" }, { "sim":209.0, @@ -411469,15 +413111,15 @@ }, { "sim":209.0, - "partner":"6oi2" + "partner":"6ujh" }, { "sim":209.0, - "partner":"6oi3" + "partner":"6pww" }, { "sim":209.0, - "partner":"6ujh" + "partner":"6dar" }, { "sim":209.0, @@ -411485,15 +413127,15 @@ }, { "sim":209.0, - "partner":"6pww" + "partner":"6das" }, { "sim":209.0, - "partner":"6dar" + "partner":"6w5m" }, { "sim":209.0, - "partner":"6das" + "partner":"6ucs" }, { "sim":209.0, @@ -411501,23 +413143,39 @@ }, { "sim":209.0, - "partner":"6w5m" + "partner":"6d9x" }, { "sim":209.0, - "partner":"6ucs" + "partner":"2h9m" }, { "sim":209.0, - "partner":"6d9x" + "partner":"6w5i" }, { "sim":209.0, - "partner":"2h9m" + "partner":"6ofz" }, { "sim":209.0, - "partner":"6w5i" + "partner":"6ujj" + }, + { + "sim":209.0, + "partner":"2h9n" + }, + { + "sim":209.0, + "partner":"6e1y" + }, + { + "sim":209.0, + "partner":"6ujl" + }, + { + "sim":209.0, + "partner":"6w5n" }, { "sim":209.0, @@ -411555,14 +413213,6 @@ "sim":209.0, "partner":"3emh" }, - { - "sim":209.0, - "partner":"2xl3" - }, - { - "sim":209.0, - "partner":"7cfp" - }, { "sim":209.0, "partner":"6kiw" @@ -411591,6 +413241,14 @@ "sim":209.0, "partner":"6kix" }, + { + "sim":209.0, + "partner":"2xl3" + }, + { + "sim":209.0, + "partner":"7cfp" + }, { "sim":209.0, "partner":"2gnq" @@ -411609,51 +413267,47 @@ }, { "sim":208.0, - "partner":"6u8l" - }, - { - "sim":208.0, - "partner":"6u5m" + "partner":"6uj4" }, { "sim":208.0, - "partner":"6uhy" + "partner":"6uif" }, { "sim":208.0, - "partner":"6uoz" + "partner":"6u5y" }, { "sim":208.0, - "partner":"6uhz" + "partner":"6uik" }, { "sim":208.0, - "partner":"6uj4" + "partner":"6u8o" }, { "sim":208.0, - "partner":"6uif" + "partner":"6dy7" }, { "sim":208.0, - "partner":"6u5y" + "partner":"6u8l" }, { "sim":208.0, - "partner":"6uik" + "partner":"6u5m" }, { "sim":208.0, - "partner":"6u8o" + "partner":"6uhy" }, { "sim":208.0, - "partner":"6dy7" + "partner":"6uoz" }, { "sim":208.0, - "partner":"6pgf" + "partner":"6uhz" }, { "sim":208.0, @@ -411687,6 +413341,10 @@ "sim":208.0, "partner":"6pge" }, + { + "sim":208.0, + "partner":"6pgf" + }, { "sim":208.0, "partner":"6iam" @@ -411783,10 +413441,6 @@ "sim":197.0, "partner":"4wjv" }, - { - "sim":197.0, - "partner":"7btb" - }, { "sim":197.0, "partner":"4v7f" @@ -411797,35 +413451,39 @@ }, { "sim":197.0, - "partner":"3jct" + "partner":"7bt6" }, { "sim":197.0, - "partner":"5jcs" + "partner":"6ft6" }, { "sim":197.0, - "partner":"7bt6" + "partner":"6ylh" }, { "sim":197.0, - "partner":"6ft6" + "partner":"3jct" }, { "sim":197.0, - "partner":"6ylh" + "partner":"5jcs" }, { "sim":197.0, "partner":"6m62" }, + { + "sim":197.0, + "partner":"6ylg" + }, { "sim":197.0, "partner":"4wju" }, { "sim":197.0, - "partner":"6ylg" + "partner":"7btb" }, { "sim":196.0, @@ -411849,35 +413507,31 @@ }, { "sim":171.0, - "partner":"7abi" + "partner":"6ff7" }, { "sim":171.0, "partner":"6ah0" }, - { - "sim":171.0, - "partner":"6ff7" - }, { "sim":171.0, "partner":"6ahd" }, { "sim":171.0, - "partner":"5xjc" + "partner":"6icz" }, { "sim":171.0, - "partner":"5z57" + "partner":"5xjc" }, { "sim":171.0, - "partner":"6icz" + "partner":"7abg" }, { "sim":171.0, - "partner":"7abg" + "partner":"5z57" }, { "sim":171.0, @@ -411889,19 +413543,23 @@ }, { "sim":171.0, - "partner":"5z56" + "partner":"7dvq" }, { "sim":171.0, "partner":"6qw6" }, + { + "sim":171.0, + "partner":"5z56" + }, { "sim":171.0, "partner":"5mqf" }, { "sim":171.0, - "partner":"7dvq" + "partner":"6qx9" }, { "sim":171.0, @@ -411913,15 +413571,15 @@ }, { "sim":171.0, - "partner":"6qx9" + "partner":"5z58" }, { "sim":171.0, - "partner":"5z58" + "partner":"6id1" }, { "sim":171.0, - "partner":"6id1" + "partner":"7abi" }, { "sim":166.0, @@ -411977,11 +413635,11 @@ }, { "sim":158.0, - "partner":"4v6w" + "partner":"6xu8" }, { "sim":158.0, - "partner":"6xu8" + "partner":"4v6w" }, { "sim":157.0, @@ -412007,10 +413665,6 @@ "sim":156.0, "partner":"6zvj" }, - { - "sim":156.0, - "partner":"6ole" - }, { "sim":156.0, "partner":"6om7" @@ -412029,28 +413683,12 @@ }, { "sim":156.0, - "partner":"6yam" - }, - { - "sim":156.0, - "partner":"6fec" - }, - { - "sim":156.0, - "partner":"6mtb" - }, - { - "sim":156.0, - "partner":"6zvh" + "partner":"6ole" }, { "sim":156.0, "partner":"3jaj" }, - { - "sim":156.0, - "partner":"8ukb" - }, { "sim":156.0, "partner":"6r6g" @@ -412065,11 +413703,11 @@ }, { "sim":156.0, - "partner":"3jai" + "partner":"6r6p" }, { "sim":156.0, - "partner":"6r6p" + "partner":"3jai" }, { "sim":156.0, @@ -412085,7 +413723,7 @@ }, { "sim":156.0, - "partner":"3jah" + "partner":"8ukb" }, { "sim":156.0, @@ -412095,6 +413733,10 @@ "sim":156.0, "partner":"6zvk" }, + { + "sim":156.0, + "partner":"3jah" + }, { "sim":156.0, "partner":"6r5q" @@ -412115,13 +413757,21 @@ "sim":156.0, "partner":"6mte" }, + { + "sim":156.0, + "partner":"7a01" + }, { "sim":156.0, "partner":"3jag" }, { "sim":156.0, - "partner":"7a01" + "partner":"6yam" + }, + { + "sim":156.0, + "partner":"7nwi" }, { "sim":156.0, @@ -412129,24 +413779,28 @@ }, { "sim":156.0, - "partner":"7nwi" + "partner":"6fec" }, { "sim":156.0, - "partner":"6olz" + "partner":"6mtb" }, { "sim":156.0, - "partner":"6gz4" + "partner":"6zvh" }, { "sim":156.0, - "partner":"7nwh" + "partner":"6gz4" }, { "sim":156.0, "partner":"6olg" }, + { + "sim":156.0, + "partner":"7nwh" + }, { "sim":156.0, "partner":"6gz3" @@ -412161,7 +413815,7 @@ }, { "sim":156.0, - "partner":"6zol" + "partner":"6olz" }, { "sim":156.0, @@ -412177,331 +413831,335 @@ }, { "sim":156.0, - "partner":"5lzv" + "partner":"6zol" }, { "sim":156.0, - "partner":"6zmw" + "partner":"4ujd" }, { "sim":156.0, - "partner":"7jqc" + "partner":"4uje" }, { "sim":156.0, - "partner":"4kzx" + "partner":"6p5j" }, { "sim":156.0, - "partner":"6ip6" + "partner":"4kzy" }, { "sim":156.0, - "partner":"6p5n" + "partner":"4ug0" }, { "sim":156.0, - "partner":"6w2t" + "partner":"5lzy" }, { "sim":156.0, - "partner":"6zxg" + "partner":"6zxh" }, { "sim":156.0, - "partner":"6zmi" + "partner":"3j7p" }, { "sim":156.0, - "partner":"4ujd" + "partner":"6hcf" }, { "sim":156.0, - "partner":"4uje" + "partner":"6z6l" }, { "sim":156.0, - "partner":"7a09" + "partner":"6zmo" }, { "sim":156.0, - "partner":"7k5i" + "partner":"6p5k" }, { "sim":156.0, - "partner":"4kzy" + "partner":"6zm7" }, { "sim":156.0, - "partner":"4ug0" + "partner":"6zme" }, { "sim":156.0, - "partner":"5lzy" + "partner":"6zon" }, { "sim":156.0, - "partner":"3j7p" + "partner":"6zp4" }, { "sim":156.0, - "partner":"6p5j" + "partner":"3j7r" }, { "sim":156.0, - "partner":"6zxh" + "partner":"4kzz" }, { "sim":156.0, - "partner":"6hcf" + "partner":"7o7z" }, { "sim":156.0, - "partner":"3j7r" + "partner":"5vyc" }, { "sim":156.0, - "partner":"4kzz" + "partner":"6hcm" }, { "sim":156.0, - "partner":"6z6l" + "partner":"6sgc" }, { "sim":156.0, - "partner":"6zmo" + "partner":"6y2l" }, { "sim":156.0, - "partner":"5vyc" + "partner":"5lzu" }, { "sim":156.0, - "partner":"6p5k" + "partner":"6ip5" }, { "sim":156.0, - "partner":"6zm7" + "partner":"5lks" }, { "sim":156.0, - "partner":"6zme" + "partner":"6g18" }, { "sim":156.0, - "partner":"6zon" + "partner":"6z6n" }, { "sim":156.0, - "partner":"6zp4" + "partner":"6zlw" }, { "sim":156.0, - "partner":"7o7z" + "partner":"5lzx" }, { "sim":156.0, - "partner":"5lzu" + "partner":"6g51" }, { "sim":156.0, - "partner":"6hcm" + "partner":"6zmt" }, { "sim":156.0, - "partner":"6sgc" + "partner":"6hcq" }, { "sim":156.0, - "partner":"6y2l" + "partner":"4ujc" }, { "sim":156.0, - "partner":"5lks" + "partner":"4v6x" }, { "sim":156.0, - "partner":"5lzx" + "partner":"6zuo" }, { "sim":156.0, - "partner":"6ip5" + "partner":"6zv6" }, { "sim":156.0, - "partner":"8vft" + "partner":"6zxd" }, { "sim":156.0, - "partner":"6g18" + "partner":"6p5i" }, { "sim":156.0, - "partner":"6z6n" + "partner":"7o7y" }, { "sim":156.0, - "partner":"6zlw" + "partner":"8vft" }, { "sim":156.0, - "partner":"4ujc" + "partner":"5flx" }, { "sim":156.0, - "partner":"4v6x" + "partner":"6d90" }, { "sim":156.0, - "partner":"6g51" + "partner":"6hcj" }, { "sim":156.0, - "partner":"6zmt" + "partner":"6ip8" }, { "sim":156.0, - "partner":"6hcq" + "partner":"5lzt" }, { "sim":156.0, - "partner":"6zuo" + "partner":"6d9j" }, { "sim":156.0, - "partner":"5flx" + "partner":"6p4g" }, { "sim":156.0, - "partner":"6zv6" + "partner":"6w2s" }, { "sim":156.0, - "partner":"6zxd" + "partner":"4d61" }, { "sim":156.0, - "partner":"7o7y" + "partner":"6g5h" }, { "sim":156.0, - "partner":"5lzt" + "partner":"6zxe" }, { "sim":156.0, - "partner":"6p5i" + "partner":"7o81" }, { "sim":156.0, - "partner":"6d90" + "partner":"5lzw" }, { "sim":156.0, - "partner":"6hcj" + "partner":"5t2c" }, { "sim":156.0, - "partner":"6ip8" + "partner":"6g5i" }, { "sim":156.0, - "partner":"4d61" + "partner":"6y57" }, { "sim":156.0, - "partner":"5lzw" + "partner":"5aj0" }, { "sim":156.0, - "partner":"5t2c" + "partner":"6ybs" }, { "sim":156.0, - "partner":"6d9j" + "partner":"6z6m" }, { "sim":156.0, - "partner":"6p4g" + "partner":"6zxf" }, { "sim":156.0, - "partner":"6w2s" + "partner":"4d5l" }, { "sim":156.0, - "partner":"7o81" + "partner":"6p4h" }, { "sim":156.0, - "partner":"6g5h" + "partner":"5lzz" }, { "sim":156.0, - "partner":"6zxe" + "partner":"6g53" }, { "sim":156.0, - "partner":"5aj0" + "partner":"6y0g" }, { "sim":156.0, - "partner":"6g5i" + "partner":"7jqb" }, { "sim":156.0, - "partner":"4d5l" + "partner":"7mdz" }, { "sim":156.0, - "partner":"6y57" + "partner":"4v5z" }, { "sim":156.0, - "partner":"5lzz" + "partner":"5lzs" }, { "sim":156.0, - "partner":"6ybs" + "partner":"6zmw" }, { "sim":156.0, - "partner":"6z6m" + "partner":"7o80" }, { "sim":156.0, - "partner":"6zxf" + "partner":"6ip6" }, { "sim":156.0, - "partner":"6p4h" + "partner":"6p5n" }, { "sim":156.0, - "partner":"4v5z" + "partner":"6w2t" }, { "sim":156.0, - "partner":"5lzs" + "partner":"6zxg" }, { "sim":156.0, - "partner":"6g53" + "partner":"7jqc" }, { "sim":156.0, - "partner":"6y0g" + "partner":"5lzv" }, { "sim":156.0, - "partner":"7jqb" + "partner":"6zmi" }, { "sim":156.0, - "partner":"7mdz" + "partner":"4kzx" }, { "sim":156.0, - "partner":"7o80" + "partner":"7a09" + }, + { + "sim":156.0, + "partner":"7k5i" }, { "sim":156.0, @@ -412539,14 +414197,6 @@ "sim":153.0, "partner":"6gmh" }, - { - "sim":153.0, - "partner":"7a1g" - }, - { - "sim":153.0, - "partner":"7b7d" - }, { "sim":153.0, "partner":"6tnu" @@ -412557,11 +414207,11 @@ }, { "sim":153.0, - "partner":"6t7t" + "partner":"8uti" }, { "sim":153.0, - "partner":"8ut0" + "partner":"6t7t" }, { "sim":153.0, @@ -412573,51 +414223,43 @@ }, { "sim":153.0, - "partner":"8uti" - }, - { - "sim":153.0, - "partner":"6i7o" - }, - { - "sim":153.0, - "partner":"4v7h" + "partner":"8ut0" }, { "sim":153.0, - "partner":"6zvi" + "partner":"7a1g" }, { "sim":153.0, - "partner":"7nrd" + "partner":"7b7d" }, { "sim":153.0, - "partner":"1trj" + "partner":"4v7h" }, { "sim":153.0, - "partner":"4v92" + "partner":"6zvi" }, { "sim":153.0, - "partner":"6wdr" + "partner":"7nrd" }, { "sim":153.0, - "partner":"4u4q" + "partner":"6i7o" }, { "sim":153.0, - "partner":"5obm" + "partner":"1trj" }, { "sim":153.0, - "partner":"4u4r" + "partner":"4v92" }, { "sim":153.0, - "partner":"5tgm" + "partner":"6wdr" }, { "sim":153.0, @@ -412633,27 +414275,27 @@ }, { "sim":153.0, - "partner":"6woo" + "partner":"4uer" }, { "sim":153.0, - "partner":"4uer" + "partner":"6gqv" }, { "sim":153.0, - "partner":"4u4u" + "partner":"6q8y" }, { "sim":153.0, - "partner":"5mei" + "partner":"4u4u" }, { "sim":153.0, - "partner":"6gqv" + "partner":"5mei" }, { "sim":153.0, - "partner":"6q8y" + "partner":"5tgm" }, { "sim":153.0, @@ -412675,6 +414317,10 @@ "sim":153.0, "partner":"5ndv" }, + { + "sim":153.0, + "partner":"6gq1" + }, { "sim":153.0, "partner":"5ndw" @@ -412689,7 +414335,7 @@ }, { "sim":153.0, - "partner":"6gq1" + "partner":"6gqb" }, { "sim":153.0, @@ -412703,10 +414349,6 @@ "sim":153.0, "partner":"5dgv" }, - { - "sim":153.0, - "partner":"6gqb" - }, { "sim":153.0, "partner":"4u50" @@ -412717,15 +414359,15 @@ }, { "sim":153.0, - "partner":"5tbw" + "partner":"6s47" }, { "sim":153.0, - "partner":"4u51" + "partner":"5tbw" }, { "sim":153.0, - "partner":"6s47" + "partner":"4u51" }, { "sim":153.0, @@ -412777,79 +414419,83 @@ }, { "sim":153.0, - "partner":"3j6y" + "partner":"4u4q" }, { "sim":153.0, - "partner":"4v8y" + "partner":"5obm" }, { "sim":153.0, - "partner":"6zu9" + "partner":"4u4r" }, { "sim":153.0, - "partner":"5juo" + "partner":"6woo" }, { "sim":153.0, - "partner":"8t3f" + "partner":"6xiq" }, { "sim":153.0, - "partner":"6xiq" + "partner":"6zce" }, { "sim":153.0, - "partner":"6zce" + "partner":"8t3f" }, { "sim":153.0, "partner":"5mc6" }, + { + "sim":153.0, + "partner":"6z6j" + }, { "sim":153.0, "partner":"5jus" }, { "sim":153.0, - "partner":"6z6j" + "partner":"6t7i" }, { "sim":153.0, - "partner":"8p4v" + "partner":"6rbe" }, { "sim":153.0, - "partner":"8t2y" + "partner":"6t83" }, { "sim":153.0, - "partner":"6t7i" + "partner":"3j78" }, { "sim":153.0, - "partner":"8t3a" + "partner":"8t2y" }, { "sim":153.0, - "partner":"6rbe" + "partner":"5juu" }, { "sim":153.0, - "partner":"6t83" + "partner":"6snt" }, { "sim":153.0, - "partner":"8t30" + "partner":"8t3a" }, { "sim":153.0, - "partner":"3j78" + "partner":"8t30" }, { "sim":153.0, - "partner":"5juu" + "partner":"3j6x" }, { "sim":153.0, @@ -412857,39 +414503,39 @@ }, { "sim":153.0, - "partner":"3j6x" + "partner":"4v88" }, { "sim":153.0, - "partner":"6snt" + "partner":"6xir" }, { "sim":153.0, - "partner":"8t3e" + "partner":"8p4v" }, { "sim":153.0, - "partner":"4v88" + "partner":"4v7r" }, { "sim":153.0, - "partner":"4v7r" + "partner":"6hhq" }, { "sim":153.0, - "partner":"4v6i" + "partner":"8t3e" }, { "sim":153.0, - "partner":"5jup" + "partner":"4v6i" }, { "sim":153.0, - "partner":"6xir" + "partner":"5jup" }, { "sim":153.0, - "partner":"6hhq" + "partner":"6sv4" }, { "sim":153.0, @@ -412897,7 +414543,7 @@ }, { "sim":153.0, - "partner":"8p9a" + "partner":"6z6k" }, { "sim":153.0, @@ -412905,7 +414551,7 @@ }, { "sim":153.0, - "partner":"6sv4" + "partner":"3j77" }, { "sim":153.0, @@ -412913,15 +414559,15 @@ }, { "sim":153.0, - "partner":"6z6k" + "partner":"5jut" }, { "sim":153.0, - "partner":"3j77" + "partner":"6fai" }, { "sim":153.0, - "partner":"5jut" + "partner":"6zu9" }, { "sim":153.0, @@ -412929,12 +414575,24 @@ }, { "sim":153.0, - "partner":"6fai" + "partner":"8p9a" + }, + { + "sim":153.0, + "partner":"3j6y" + }, + { + "sim":153.0, + "partner":"4v8y" }, { "sim":153.0, "partner":"8t3b" }, + { + "sim":153.0, + "partner":"5juo" + }, { "sim":153.0, "partner":"8t3d" @@ -412969,63 +414627,63 @@ }, { "sim":150.0, - "partner":"7eg9" + "partner":"7egd" }, { "sim":150.0, - "partner":"7enc" + "partner":"7ega" }, { "sim":150.0, - "partner":"7egj" + "partner":"7egf" }, { "sim":150.0, - "partner":"7ena" + "partner":"7egi" }, { "sim":150.0, - "partner":"7egd" + "partner":"7egc" }, { "sim":150.0, - "partner":"7ega" + "partner":"7edx" }, { "sim":150.0, - "partner":"7egf" + "partner":"7eg7" }, { "sim":150.0, - "partner":"7egi" + "partner":"7egg" }, { "sim":150.0, - "partner":"7egc" + "partner":"7eg8" }, { "sim":150.0, - "partner":"7edx" + "partner":"7egb" }, { "sim":150.0, - "partner":"7eg7" + "partner":"7ege" }, { "sim":150.0, - "partner":"7egg" + "partner":"7eg9" }, { "sim":150.0, - "partner":"7eg8" + "partner":"7enc" }, { "sim":150.0, - "partner":"7egb" + "partner":"7egj" }, { "sim":150.0, - "partner":"7ege" + "partner":"7ena" }, { "sim":149.0, @@ -413049,11 +414707,11 @@ }, { "sim":148.0, - "partner":"6t9k" + "partner":"6t9i" }, { "sim":148.0, - "partner":"6t9i" + "partner":"6t9k" }, { "sim":144.0, @@ -413129,83 +414787,83 @@ }, { "sim":141.0, - "partner":"5ukk" + "partner":"8wgb" }, { "sim":141.0, - "partner":"7dfl" + "partner":"5ukl" }, { "sim":141.0, - "partner":"7k7z" + "partner":"6gdg" }, { "sim":141.0, - "partner":"7jjo" + "partner":"4mk0" }, { "sim":141.0, - "partner":"5ukl" + "partner":"5he0" }, { "sim":141.0, - "partner":"6gdg" + "partner":"5he1" }, { "sim":141.0, - "partner":"4mk0" + "partner":"7k7l" }, { "sim":141.0, - "partner":"5he0" + "partner":"6g79" }, { "sim":141.0, - "partner":"5he1" + "partner":"5he2" }, { "sim":141.0, - "partner":"7k7l" + "partner":"5he3" }, { "sim":141.0, - "partner":"5he2" + "partner":"7dfl" }, { "sim":141.0, - "partner":"6g79" + "partner":"5ukk" }, { "sim":141.0, - "partner":"8wgb" + "partner":"7k7z" }, { "sim":141.0, - "partner":"5he3" + "partner":"7jjo" }, { "sim":141.0, - "partner":"6wi9" + "partner":"7dhr" }, { "sim":141.0, - "partner":"7o7f" + "partner":"8k4s" }, { "sim":141.0, - "partner":"4kfm" + "partner":"5kdo" }, { "sim":141.0, - "partner":"6x18" + "partner":"6pcv" }, { "sim":141.0, - "partner":"5kdo" + "partner":"6vms" }, { "sim":141.0, - "partner":"7dhr" + "partner":"6x19" }, { "sim":141.0, @@ -413213,19 +414871,19 @@ }, { "sim":141.0, - "partner":"6pcv" + "partner":"8p15" }, { "sim":141.0, - "partner":"6vms" + "partner":"6niy" }, { "sim":141.0, - "partner":"6x19" + "partner":"7f1q" }, { "sim":141.0, - "partner":"6niy" + "partner":"8vve" }, { "sim":141.0, @@ -413233,15 +414891,19 @@ }, { "sim":141.0, - "partner":"7f1q" + "partner":"7lci" }, { "sim":141.0, - "partner":"7lci" + "partner":"7f1r" }, { "sim":141.0, - "partner":"8k4s" + "partner":"8vvf" + }, + { + "sim":141.0, + "partner":"6c2y" }, { "sim":141.0, @@ -413249,27 +414911,27 @@ }, { "sim":141.0, - "partner":"1gg2" + "partner":"6kpf" }, { "sim":141.0, - "partner":"3pvu" + "partner":"8zjg" }, { "sim":141.0, - "partner":"4pnk" + "partner":"3pvu" }, { "sim":141.0, - "partner":"6c2y" + "partner":"4pnk" }, { "sim":141.0, - "partner":"7f1r" + "partner":"7bz2" }, { "sim":141.0, - "partner":"8p12" + "partner":"7f1s" }, { "sim":141.0, @@ -413281,7 +414943,7 @@ }, { "sim":141.0, - "partner":"6kpf" + "partner":"7dhi" }, { "sim":141.0, @@ -413289,27 +414951,27 @@ }, { "sim":141.0, - "partner":"7bz2" + "partner":"6whc" }, { "sim":141.0, - "partner":"1gp2" + "partner":"8vvg" }, { "sim":141.0, - "partner":"5wg3" + "partner":"1gg2" }, { "sim":141.0, - "partner":"6whc" + "partner":"5wg3" }, { "sim":141.0, - "partner":"7dhi" + "partner":"7ki1" }, { "sim":141.0, - "partner":"7f1s" + "partner":"7mbx" }, { "sim":141.0, @@ -413317,11 +414979,7 @@ }, { "sim":141.0, - "partner":"7ki1" - }, - { - "sim":141.0, - "partner":"7mbx" + "partner":"6wzg" }, { "sim":141.0, @@ -413333,7 +414991,7 @@ }, { "sim":141.0, - "partner":"8p13" + "partner":"1gp2" }, { "sim":141.0, @@ -413343,10 +415001,6 @@ "sim":141.0, "partner":"5wg4" }, - { - "sim":141.0, - "partner":"6wzg" - }, { "sim":141.0, "partner":"1xhm" @@ -413357,11 +415011,11 @@ }, { "sim":141.0, - "partner":"3krw" + "partner":"6qno" }, { "sim":141.0, - "partner":"5wg5" + "partner":"6rmv" }, { "sim":141.0, @@ -413373,15 +415027,19 @@ }, { "sim":141.0, - "partner":"6qno" + "partner":"8p12" }, { "sim":141.0, - "partner":"6rmv" + "partner":"8xqe" }, { "sim":141.0, - "partner":"3krx" + "partner":"3krw" + }, + { + "sim":141.0, + "partner":"5wg5" }, { "sim":141.0, @@ -413389,7 +415047,11 @@ }, { "sim":141.0, - "partner":"8p15" + "partner":"8z7j" + }, + { + "sim":141.0, + "partner":"3krx" }, { "sim":141.0, @@ -413397,7 +415059,27 @@ }, { "sim":141.0, - "partner":"6m1h" + "partner":"6wi9" + }, + { + "sim":141.0, + "partner":"6x18" + }, + { + "sim":141.0, + "partner":"7o7f" + }, + { + "sim":141.0, + "partner":"8p13" + }, + { + "sim":141.0, + "partner":"8xqf" + }, + { + "sim":141.0, + "partner":"4kfm" }, { "sim":141.0, @@ -413405,11 +415087,11 @@ }, { "sim":141.0, - "partner":"5tdh" + "partner":"6m1h" }, { "sim":141.0, - "partner":"6xbk" + "partner":"5tdh" }, { "sim":141.0, @@ -413433,11 +415115,11 @@ }, { "sim":141.0, - "partner":"6dde" + "partner":"7db6" }, { "sim":141.0, - "partner":"7db6" + "partner":"6dde" }, { "sim":141.0, @@ -413449,28 +415131,16 @@ }, { "sim":141.0, - "partner":"6nbi" - }, - { - "sim":141.0, - "partner":"6oij" - }, - { - "sim":141.0, - "partner":"7duq" + "partner":"6xbk" }, { "sim":141.0, - "partner":"7e32" + "partner":"7dur" }, { "sim":141.0, "partner":"6oik" }, - { - "sim":141.0, - "partner":"7dur" - }, { "sim":141.0, "partner":"7e33" @@ -413483,6 +415153,10 @@ "sim":141.0, "partner":"7evm" }, + { + "sim":141.0, + "partner":"7e2x" + }, { "sim":141.0, "partner":"7jhj" @@ -413497,15 +415171,15 @@ }, { "sim":141.0, - "partner":"7e2x" + "partner":"7cmu" }, { "sim":141.0, - "partner":"6pb0" + "partner":"7e2y" }, { "sim":141.0, - "partner":"7cmu" + "partner":"6pb0" }, { "sim":141.0, @@ -413513,11 +415187,11 @@ }, { "sim":141.0, - "partner":"7e2y" + "partner":"7exd" }, { "sim":141.0, - "partner":"7exd" + "partner":"7e14" }, { "sim":141.0, @@ -413525,7 +415199,7 @@ }, { "sim":141.0, - "partner":"7e14" + "partner":"7e2z" }, { "sim":141.0, @@ -413533,15 +415207,27 @@ }, { "sim":141.0, - "partner":"7e2z" + "partner":"6pb1" }, { "sim":141.0, - "partner":"6pb1" + "partner":"6crk" }, { "sim":141.0, - "partner":"6crk" + "partner":"6nbi" + }, + { + "sim":141.0, + "partner":"7duq" + }, + { + "sim":141.0, + "partner":"7e32" + }, + { + "sim":141.0, + "partner":"6oij" }, { "sim":141.0, @@ -413561,11 +415247,11 @@ }, { "sim":141.0, - "partner":"7jvr" + "partner":"7ckz" }, { "sim":141.0, - "partner":"7ckz" + "partner":"7jvr" }, { "sim":141.0, @@ -413581,47 +415267,43 @@ }, { "sim":141.0, - "partner":"6d9h" - }, - { - "sim":141.0, - "partner":"6p9x" + "partner":"6vcb" }, { "sim":141.0, - "partner":"6uva" + "partner":"7joz" }, { "sim":141.0, - "partner":"6k42" + "partner":"6p9y" }, { "sim":141.0, - "partner":"6xox" + "partner":"8xx3" }, { "sim":141.0, - "partner":"6vcb" + "partner":"5ukm" }, { "sim":141.0, - "partner":"7joz" + "partner":"6e3y" }, { "sim":141.0, - "partner":"5ukm" + "partner":"7ld3" }, { "sim":141.0, - "partner":"6p9y" + "partner":"6m8s" }, { "sim":141.0, - "partner":"7ld3" + "partner":"6ni3" }, { "sim":141.0, - "partner":"6e3y" + "partner":"7c2e" }, { "sim":141.0, @@ -413629,15 +415311,15 @@ }, { "sim":141.0, - "partner":"6m8s" + "partner":"8xx7" }, { "sim":141.0, - "partner":"6ni3" + "partner":"8xwv" }, { "sim":141.0, - "partner":"7c2e" + "partner":"8xxh" }, { "sim":141.0, @@ -413651,13 +415333,21 @@ "sim":141.0, "partner":"6orv" }, + { + "sim":141.0, + "partner":"8tyw" + }, { "sim":141.0, "partner":"6uus" }, { "sim":141.0, - "partner":"8tyw" + "partner":"8jzp" + }, + { + "sim":141.0, + "partner":"8xxx" }, { "sim":141.0, @@ -413665,7 +415355,31 @@ }, { "sim":141.0, - "partner":"7e9h" + "partner":"8xxr" + }, + { + "sim":141.0, + "partner":"6d9h" + }, + { + "sim":141.0, + "partner":"6p9x" + }, + { + "sim":141.0, + "partner":"6uva" + }, + { + "sim":141.0, + "partner":"8xx6" + }, + { + "sim":141.0, + "partner":"6k42" + }, + { + "sim":141.0, + "partner":"6xox" }, { "sim":141.0, @@ -413705,15 +415419,15 @@ }, { "sim":141.0, - "partner":"3sn6" + "partner":"7e9g" }, { "sim":141.0, - "partner":"7e9g" + "partner":"7ezm" }, { "sim":141.0, - "partner":"7ezm" + "partner":"3sn6" }, { "sim":141.0, @@ -413723,6 +415437,10 @@ "sim":141.0, "partner":"6ot0" }, + { + "sim":141.0, + "partner":"7e9h" + }, { "sim":141.0, "partner":"7ljc" @@ -413753,15 +415471,15 @@ }, { "sim":141.0, - "partner":"7ckx" + "partner":"8x3l" }, { "sim":141.0, - "partner":"7crh" + "partner":"7ckx" }, { "sim":141.0, - "partner":"8x3l" + "partner":"7crh" }, { "sim":141.0, @@ -413771,21 +415489,17 @@ "sim":141.0, "partner":"7aue" }, - { - "sim":141.0, - "partner":"7cx2" - }, { "sim":141.0, "partner":"6wpw" }, { "sim":141.0, - "partner":"8rql" + "partner":"7cx3" }, { "sim":141.0, - "partner":"7cx3" + "partner":"8rql" }, { "sim":141.0, @@ -413809,7 +415523,7 @@ }, { "sim":141.0, - "partner":"7l0r" + "partner":"7cx2" }, { "sim":141.0, @@ -413825,31 +415539,31 @@ }, { "sim":141.0, - "partner":"7f4h" + "partner":"7l0r" }, { "sim":141.0, - "partner":"7f9y" + "partner":"8zfz" }, { "sim":141.0, - "partner":"7f16" + "partner":"7f4d" }, { "sim":141.0, - "partner":"7dw9" + "partner":"8vhf" }, { "sim":141.0, - "partner":"7f4d" + "partner":"7f9z" }, { "sim":141.0, - "partner":"7f9z" + "partner":"7f4i" }, { "sim":141.0, - "partner":"7f4i" + "partner":"7f4f" }, { "sim":141.0, @@ -413857,23 +415571,39 @@ }, { "sim":141.0, - "partner":"7f4f" + "partner":"7bb6" }, { "sim":141.0, - "partner":"7bb6" + "partner":"7bb7" }, { "sim":141.0, - "partner":"8vhf" + "partner":"7dty" }, { "sim":141.0, - "partner":"7bb7" + "partner":"7f4h" }, { "sim":141.0, - "partner":"7dty" + "partner":"7f9y" + }, + { + "sim":141.0, + "partner":"7f16" + }, + { + "sim":141.0, + "partner":"7dw9" + }, + { + "sim":141.0, + "partner":"8wwi" + }, + { + "sim":141.0, + "partner":"8wwj" }, { "sim":141.0, @@ -413897,15 +415627,11 @@ }, { "sim":141.0, - "partner":"8wwi" - }, - { - "sim":141.0, - "partner":"8wwj" + "partner":"6vn7" }, { "sim":141.0, - "partner":"6vn7" + "partner":"8jsr" }, { "sim":141.0, @@ -413917,11 +415643,11 @@ }, { "sim":140.0, - "partner":"1got" + "partner":"2trc" }, { "sim":140.0, - "partner":"2trc" + "partner":"1got" }, { "sim":140.0, @@ -413943,10 +415669,6 @@ "sim":140.0, "partner":"1a0r" }, - { - "sim":140.0, - "partner":"6rxy" - }, { "sim":140.0, "partner":"5oql" @@ -413971,6 +415693,10 @@ "sim":140.0, "partner":"6rxt" }, + { + "sim":140.0, + "partner":"6rxy" + }, { "sim":138.0, "partner":"6az1" @@ -414003,14 +415729,6 @@ "sim":137.0, "partner":"6lqs" }, - { - "sim":137.0, - "partner":"7ajt" - }, - { - "sim":137.0, - "partner":"6zqb" - }, { "sim":137.0, "partner":"6lqr" @@ -414079,6 +415797,14 @@ "sim":137.0, "partner":"6lqq" }, + { + "sim":137.0, + "partner":"7ajt" + }, + { + "sim":137.0, + "partner":"6zqb" + }, { "sim":136.0, "partner":"3jb9" @@ -414101,15 +415827,11 @@ }, { "sim":135.0, - "partner":"3jam" - }, - { - "sim":135.0, - "partner":"3jap" + "partner":"6fyx" }, { "sim":135.0, - "partner":"6fyy" + "partner":"6uz7" }, { "sim":135.0, @@ -414117,27 +415839,27 @@ }, { "sim":135.0, - "partner":"6fyx" + "partner":"3j81" }, { "sim":135.0, - "partner":"6uz7" + "partner":"8s8k" }, { "sim":135.0, - "partner":"3j81" + "partner":"3jam" }, { "sim":135.0, - "partner":"8s8k" + "partner":"3jap" }, { "sim":135.0, - "partner":"6wnx" + "partner":"6fyy" }, { "sim":135.0, - "partner":"6m90" + "partner":"6wnx" }, { "sim":135.0, @@ -414155,6 +415877,10 @@ "sim":135.0, "partner":"6m94" }, + { + "sim":135.0, + "partner":"6m90" + }, { "sim":135.0, "partner":"1p22" @@ -414251,17 +415977,13 @@ "sim":129.0, "partner":"7dco" }, - { - "sim":129.0, - "partner":"4v5o" - }, { "sim":129.0, "partner":"4bts" }, { "sim":129.0, - "partner":"7b9v" + "partner":"4v5o" }, { "sim":129.0, @@ -414273,11 +415995,11 @@ }, { "sim":129.0, - "partner":"5wsg" + "partner":"6j6q" }, { "sim":129.0, - "partner":"6j6q" + "partner":"5wsg" }, { "sim":129.0, @@ -414291,6 +416013,10 @@ "sim":129.0, "partner":"5y88" }, + { + "sim":129.0, + "partner":"6j6g" + }, { "sim":129.0, "partner":"5gm6" @@ -414301,7 +416027,7 @@ }, { "sim":129.0, - "partner":"6j6g" + "partner":"6j6n" }, { "sim":129.0, @@ -414309,23 +416035,23 @@ }, { "sim":129.0, - "partner":"6j6n" + "partner":"5lqw" }, { "sim":129.0, - "partner":"5lqw" + "partner":"6j6h" }, { "sim":129.0, - "partner":"5mps" + "partner":"7b9v" }, { "sim":129.0, - "partner":"5ylz" + "partner":"5mps" }, { "sim":129.0, - "partner":"6j6h" + "partner":"5ylz" }, { "sim":126.0, @@ -414437,11 +416163,11 @@ }, { "sim":111.0, - "partner":"1pev" + "partner":"1nr0" }, { "sim":111.0, - "partner":"1nr0" + "partner":"1pev" }, { "sim":109.0, @@ -414485,27 +416211,27 @@ }, { "sim":104.0, - "partner":"5khr" + "partner":"6q6h" }, { "sim":104.0, - "partner":"6f0x" + "partner":"6q6g" }, { "sim":104.0, - "partner":"6q6h" + "partner":"5khu" }, { "sim":104.0, - "partner":"5khu" + "partner":"5g04" }, { "sim":104.0, - "partner":"6q6g" + "partner":"6f0x" }, { "sim":104.0, - "partner":"5g04" + "partner":"5khr" }, { "sim":102.0, @@ -414529,15 +416255,15 @@ }, { "sim":101.0, - "partner":"7ay2" + "partner":"5k1c" }, { "sim":101.0, - "partner":"5k1c" + "partner":"7ay0" }, { "sim":101.0, - "partner":"7ay0" + "partner":"7ay2" }, { "sim":101.0, @@ -414591,25 +416317,17 @@ "sim":99.0, "partner":"1nex" }, - { - "sim":97.0, - "partner":"5flc" - }, - { - "sim":97.0, - "partner":"6sb0" - }, { "sim":97.0, "partner":"4jsv" }, { "sim":97.0, - "partner":"5h64" + "partner":"7pea" }, { "sim":97.0, - "partner":"7pea" + "partner":"5h64" }, { "sim":97.0, @@ -414657,11 +416375,11 @@ }, { "sim":97.0, - "partner":"4jt6" + "partner":"6zwo" }, { "sim":97.0, - "partner":"6zwo" + "partner":"4jt6" }, { "sim":97.0, @@ -414681,12 +416399,20 @@ }, { "sim":97.0, - "partner":"5wbu" + "partner":"6sb0" + }, + { + "sim":97.0, + "partner":"5flc" }, { "sim":97.0, "partner":"5wby" }, + { + "sim":97.0, + "partner":"5wbu" + }, { "sim":96.0, "partner":"6rm3" @@ -414721,43 +416447,43 @@ }, { "sim":92.0, - "partner":"3mzk" + "partner":"3mzl" }, { "sim":92.0, - "partner":"6zg5" + "partner":"6zg6" }, { "sim":92.0, - "partner":"4xmm" + "partner":"3iko" }, { "sim":92.0, - "partner":"3mzl" + "partner":"4xmn" }, { "sim":92.0, - "partner":"3iko" + "partner":"2pm6" }, { "sim":92.0, - "partner":"6zg6" + "partner":"6zl0" }, { "sim":92.0, - "partner":"4xmn" + "partner":"4bzk" }, { "sim":92.0, - "partner":"2pm6" + "partner":"6zg5" }, { "sim":92.0, - "partner":"6zl0" + "partner":"3mzk" }, { "sim":92.0, - "partner":"4bzk" + "partner":"4xmm" }, { "sim":92.0, @@ -414785,11 +416511,11 @@ }, { "sim":90.0, - "partner":"6uh5" + "partner":"6ugm" }, { "sim":90.0, - "partner":"6ugm" + "partner":"6uh5" }, { "sim":87.0, @@ -414841,27 +416567,23 @@ }, { "sim":84.0, - "partner":"2xu7" - }, - { - "sim":84.0, - "partner":"7ktp" + "partner":"6g16" }, { "sim":84.0, - "partner":"6g16" + "partner":"7aoa" }, { "sim":84.0, - "partner":"5fxy" + "partner":"8vml" }, { "sim":84.0, - "partner":"7aoa" + "partner":"6c24" }, { "sim":84.0, - "partner":"6c24" + "partner":"5fxy" }, { "sim":84.0, @@ -414875,18 +416597,26 @@ "sim":84.0, "partner":"4pby" }, + { + "sim":84.0, + "partner":"8vmi" + }, { "sim":84.0, "partner":"4pbz" }, { "sim":84.0, - "partner":"4pc0" + "partner":"8vnv" }, { "sim":84.0, "partner":"7ksr" }, + { + "sim":84.0, + "partner":"4pc0" + }, { "sim":84.0, "partner":"6c23" @@ -414895,13 +416625,25 @@ "sim":84.0, "partner":"7kso" }, + { + "sim":84.0, + "partner":"6zrd" + }, + { + "sim":84.0, + "partner":"8vnz" + }, { "sim":84.0, "partner":"3gfc" }, { "sim":84.0, - "partner":"6zrd" + "partner":"2xu7" + }, + { + "sim":84.0, + "partner":"7ktp" }, { "sim":84.0, @@ -414919,10 +416661,6 @@ "sim":84.0, "partner":"5vtb" }, - { - "sim":84.0, - "partner":"6nq3" - }, { "sim":84.0, "partner":"5wai" @@ -414933,7 +416671,7 @@ }, { "sim":84.0, - "partner":"5xwr" + "partner":"6nq3" }, { "sim":84.0, @@ -414941,16 +416679,20 @@ }, { "sim":84.0, - "partner":"8tx8" + "partner":"5xwr" }, { "sim":84.0, - "partner":"5xxq" + "partner":"8tx8" }, { "sim":84.0, "partner":"5y1u" }, + { + "sim":84.0, + "partner":"5xxq" + }, { "sim":82.0, "partner":"7klj" @@ -415033,11 +416775,11 @@ }, { "sim":75.0, - "partner":"5vh9" + "partner":"5vlj" }, { "sim":75.0, - "partner":"5vlj" + "partner":"5vh9" }, { "sim":74.0, @@ -415053,11 +416795,11 @@ }, { "sim":74.0, - "partner":"5m2n" + "partner":"6qk7" }, { "sim":74.0, - "partner":"6qk7" + "partner":"5m2n" }, { "sim":74.0, @@ -415065,15 +416807,15 @@ }, { "sim":73.0, - "partner":"3f3g" + "partner":"3f3p" }, { "sim":73.0, - "partner":"3f3p" + "partner":"3f3f" }, { "sim":73.0, - "partner":"3f3f" + "partner":"3f3g" }, { "sim":73.0, @@ -415179,14 +416921,6 @@ "sim":67.0, "partner":"6r92" }, - { - "sim":66.0, - "partner":"5m5g" - }, - { - "sim":66.0, - "partner":"5wfd" - }, { "sim":66.0, "partner":"5bjs" @@ -415220,16 +416954,12 @@ "partner":"5wfc" }, { - "sim":63.0, - "partner":"6qtv" - }, - { - "sim":63.0, - "partner":"6qtw" + "sim":66.0, + "partner":"5m5g" }, { - "sim":63.0, - "partner":"6qtx" + "sim":66.0, + "partner":"5wfd" }, { "sim":63.0, @@ -415251,6 +416981,18 @@ "sim":63.0, "partner":"6qtu" }, + { + "sim":63.0, + "partner":"6qtv" + }, + { + "sim":63.0, + "partner":"6qtw" + }, + { + "sim":63.0, + "partner":"6qtx" + }, { "sim":63.0, "partner":"5kwn" @@ -415285,19 +417027,19 @@ }, { "sim":57.0, - "partner":"2aq5" + "partner":"2b4e" }, { "sim":57.0, - "partner":"2b4e" + "partner":"2aq5" }, { "sim":56.0, - "partner":"7m05" + "partner":"6v0n" }, { "sim":56.0, - "partner":"6v0n" + "partner":"7m05" }, { "sim":56.0, @@ -415325,63 +417067,63 @@ }, { "sim":56.0, - "partner":"4x63" + "partner":"4x60" }, { "sim":56.0, - "partner":"7kid" + "partner":"4x61" }, { "sim":56.0, - "partner":"6uxx" + "partner":"5c9z" }, { "sim":56.0, - "partner":"6uxy" + "partner":"5emj" }, { "sim":56.0, - "partner":"4x60" + "partner":"6k1s" }, { "sim":56.0, - "partner":"4x61" + "partner":"7l1g" }, { "sim":56.0, - "partner":"5c9z" + "partner":"5emk" }, { "sim":56.0, - "partner":"5emj" + "partner":"5eml" }, { "sim":56.0, - "partner":"5emk" + "partner":"7kib" }, { "sim":56.0, - "partner":"6k1s" + "partner":"5emm" }, { "sim":56.0, - "partner":"7l1g" + "partner":"7kic" }, { "sim":56.0, - "partner":"5eml" + "partner":"6uxx" }, { "sim":56.0, - "partner":"7kib" + "partner":"7kid" }, { "sim":56.0, - "partner":"5emm" + "partner":"4x63" }, { "sim":56.0, - "partner":"7kic" + "partner":"6uxy" }, { "sim":56.0, @@ -415513,67 +417255,67 @@ "synthetic construct" ], "keywords":[ - "stability", - "diverse", + "templates", + "repeats", "analysis", - "evolution", - "consisting", - "constraints", - "functional", - "proteins", - "large", - "reveals", - "architecture", - "multiple", - "unique", - "common", - "showing", - "study", - "formula", - "characterized", - "template", - "tools", - "artificial", - "fold", - "test", - "see", + "engineering", "engineered", + "design", + "characterized", + "perfectly", + "diverse", + "help", + "geometrical", "used", - "highly", - "approaches", - "useful", "suggests", + "functional", + "natural", + "multiple", + "approaches", + "based", + "permutation", + "consisting", + "discovered", + "fold", + "text", + "symmetrical", + "template", + "protein", "nature", + "useful", + "study", + "stability", + "showing", + "proteins", + "large", + "sequential", "symmetric", - "help", - "engineering", - "geometrical", + "artificial", + "tools", "systematic", + "architecture", + "see", + "constraints", "far", - "based", - "design", - "symmetrical", - "variation", - "protein", - "using", - "templates", - "natural", - "perfectly", - "discovered", - "describe", - "sequence", - "repeats", + "test", + "highly", "constraint", - "text", + "sequence", + "common", + "reveals", "circular", + "contain", + "created", + "evolution", + "formula", "monomer", - "computational", + "describe", "effects", - "could", - "permutation", - "sequential", - "contain", - "created" + "unique", + "variation", + "computational", + "using", + "could" ], "release_date":"2021-09-22", "publication":"\"Structure and stability of the designer protein WRAP-T and its permutants\", Sci Rep, 11, 18867-18867", @@ -415626,19 +417368,19 @@ }, { "sim":238.0, - "partner":"6g6n" + "partner":"6g6m" }, { "sim":238.0, - "partner":"6y7p" + "partner":"6y7n" }, { "sim":238.0, - "partner":"6y7n" + "partner":"6g6n" }, { "sim":238.0, - "partner":"6g6m" + "partner":"6y7p" }, { "sim":178.0, @@ -415670,10 +417412,6 @@ "sim":199.0, "partner":"5mzh" }, - { - "sim":198.0, - "partner":"5eap" - }, { "sim":198.0, "partner":"3ur4" @@ -415712,7 +417450,7 @@ }, { "sim":198.0, - "partner":"2h9n" + "partner":"5eap" }, { "sim":198.0, @@ -415722,6 +417460,10 @@ "sim":198.0, "partner":"2h9m" }, + { + "sim":198.0, + "partner":"2h9n" + }, { "sim":198.0, "partner":"6pg3" @@ -415758,14 +417500,6 @@ "sim":198.0, "partner":"3n0e" }, - { - "sim":198.0, - "partner":"2xl3" - }, - { - "sim":198.0, - "partner":"7cfp" - }, { "sim":198.0, "partner":"6kiw" @@ -415794,6 +417528,14 @@ "sim":198.0, "partner":"6kix" }, + { + "sim":198.0, + "partner":"2xl3" + }, + { + "sim":198.0, + "partner":"7cfp" + }, { "sim":198.0, "partner":"2gnq" @@ -415812,51 +417554,47 @@ }, { "sim":197.0, - "partner":"6u8l" - }, - { - "sim":197.0, - "partner":"6u5m" + "partner":"6uj4" }, { "sim":197.0, - "partner":"6uhy" + "partner":"6uif" }, { "sim":197.0, - "partner":"6uoz" + "partner":"6u5y" }, { "sim":197.0, - "partner":"6uhz" + "partner":"6uik" }, { "sim":197.0, - "partner":"6uj4" + "partner":"6u8o" }, { "sim":197.0, - "partner":"6uif" + "partner":"6dy7" }, { "sim":197.0, - "partner":"6u5y" + "partner":"6u8l" }, { "sim":197.0, - "partner":"6uik" + "partner":"6u5m" }, { "sim":197.0, - "partner":"6u8o" + "partner":"6uhy" }, { "sim":197.0, - "partner":"6dy7" + "partner":"6uoz" }, { "sim":197.0, - "partner":"6pgf" + "partner":"6uhz" }, { "sim":197.0, @@ -415896,23 +417634,19 @@ }, { "sim":197.0, - "partner":"6iam" - }, - { - "sim":197.0, - "partner":"6byn" + "partner":"6pgf" }, { "sim":197.0, - "partner":"2g99" + "partner":"6iam" }, { "sim":197.0, - "partner":"5vfc" + "partner":"6byn" }, { "sim":197.0, - "partner":"6u6w" + "partner":"2g99" }, { "sim":197.0, @@ -415928,7 +417662,11 @@ }, { "sim":197.0, - "partner":"2h6k" + "partner":"6u6w" + }, + { + "sim":197.0, + "partner":"5vfc" }, { "sim":197.0, @@ -415972,19 +417710,11 @@ }, { "sim":197.0, - "partner":"6ofz" - }, - { - "sim":197.0, - "partner":"6ujj" - }, - { - "sim":197.0, - "partner":"6e1y" + "partner":"2h6k" }, { "sim":197.0, - "partner":"6ujl" + "partner":"6dai" }, { "sim":197.0, @@ -415992,11 +417722,11 @@ }, { "sim":197.0, - "partner":"6w5n" + "partner":"6pwv" }, { "sim":197.0, - "partner":"6dai" + "partner":"6dak" }, { "sim":197.0, @@ -416004,27 +417734,27 @@ }, { "sim":197.0, - "partner":"6pwv" + "partner":"6e22" }, { "sim":197.0, - "partner":"6dak" + "partner":"6wjq" }, { "sim":197.0, - "partner":"6e22" + "partner":"6e23" }, { "sim":197.0, - "partner":"6wjq" + "partner":"6oi0" }, { "sim":197.0, - "partner":"6e23" + "partner":"6oi1" }, { "sim":197.0, - "partner":"6oi0" + "partner":"6oi2" }, { "sim":197.0, @@ -416032,7 +417762,7 @@ }, { "sim":197.0, - "partner":"6oi1" + "partner":"6oi3" }, { "sim":197.0, @@ -416044,15 +417774,15 @@ }, { "sim":197.0, - "partner":"6oi2" + "partner":"6ujh" }, { "sim":197.0, - "partner":"6oi3" + "partner":"6pww" }, { "sim":197.0, - "partner":"6ujh" + "partner":"6dar" }, { "sim":197.0, @@ -416060,35 +417790,47 @@ }, { "sim":197.0, - "partner":"6pww" + "partner":"6das" }, { "sim":197.0, - "partner":"6dar" + "partner":"7dno" }, { "sim":197.0, - "partner":"6das" + "partner":"6w5m" }, { "sim":197.0, - "partner":"6w5m" + "partner":"6ucs" }, { "sim":197.0, - "partner":"7dno" + "partner":"6d9x" }, { "sim":197.0, - "partner":"6ucs" + "partner":"6w5i" }, { "sim":197.0, - "partner":"6d9x" + "partner":"6ofz" }, { "sim":197.0, - "partner":"6w5i" + "partner":"6ujj" + }, + { + "sim":197.0, + "partner":"6e1y" + }, + { + "sim":197.0, + "partner":"6ujl" + }, + { + "sim":197.0, + "partner":"6w5n" }, { "sim":197.0, @@ -416162,6 +417904,10 @@ "sim":196.0, "partner":"3mxx" }, + { + "sim":186.0, + "partner":"8rl2" + }, { "sim":184.0, "partner":"7mt1" @@ -416174,10 +417920,6 @@ "sim":177.0, "partner":"4wjv" }, - { - "sim":177.0, - "partner":"7btb" - }, { "sim":177.0, "partner":"4v7f" @@ -416188,35 +417930,39 @@ }, { "sim":177.0, - "partner":"3jct" + "partner":"7bt6" }, { "sim":177.0, - "partner":"5jcs" + "partner":"6ft6" }, { "sim":177.0, - "partner":"7bt6" + "partner":"6ylh" }, { "sim":177.0, - "partner":"6ft6" + "partner":"3jct" }, { "sim":177.0, - "partner":"6ylh" + "partner":"5jcs" }, { "sim":177.0, "partner":"6m62" }, + { + "sim":177.0, + "partner":"6ylg" + }, { "sim":177.0, "partner":"4wju" }, { "sim":177.0, - "partner":"6ylg" + "partner":"7btb" }, { "sim":175.0, @@ -416232,35 +417978,31 @@ }, { "sim":167.0, - "partner":"7abi" + "partner":"6ff7" }, { "sim":167.0, "partner":"6ah0" }, - { - "sim":167.0, - "partner":"6ff7" - }, { "sim":167.0, "partner":"6ahd" }, { "sim":167.0, - "partner":"5xjc" + "partner":"6icz" }, { "sim":167.0, - "partner":"5z57" + "partner":"5xjc" }, { "sim":167.0, - "partner":"6icz" + "partner":"7abg" }, { "sim":167.0, - "partner":"7abg" + "partner":"5z57" }, { "sim":167.0, @@ -416272,19 +418014,23 @@ }, { "sim":167.0, - "partner":"5z56" + "partner":"7dvq" }, { "sim":167.0, "partner":"6qw6" }, + { + "sim":167.0, + "partner":"5z56" + }, { "sim":167.0, "partner":"5mqf" }, { "sim":167.0, - "partner":"7dvq" + "partner":"6qx9" }, { "sim":167.0, @@ -416296,15 +418042,15 @@ }, { "sim":167.0, - "partner":"6qx9" + "partner":"5z58" }, { "sim":167.0, - "partner":"5z58" + "partner":"6id1" }, { "sim":167.0, - "partner":"6id1" + "partner":"7abi" }, { "sim":161.0, @@ -416354,10 +418100,6 @@ "sim":149.0, "partner":"6zvj" }, - { - "sim":149.0, - "partner":"6ole" - }, { "sim":149.0, "partner":"6om7" @@ -416376,28 +418118,12 @@ }, { "sim":149.0, - "partner":"6yam" - }, - { - "sim":149.0, - "partner":"6fec" - }, - { - "sim":149.0, - "partner":"6mtb" - }, - { - "sim":149.0, - "partner":"6zvh" + "partner":"6ole" }, { "sim":149.0, "partner":"3jaj" }, - { - "sim":149.0, - "partner":"8ukb" - }, { "sim":149.0, "partner":"6r6g" @@ -416412,11 +418138,11 @@ }, { "sim":149.0, - "partner":"3jai" + "partner":"6r6p" }, { "sim":149.0, - "partner":"6r6p" + "partner":"3jai" }, { "sim":149.0, @@ -416432,7 +418158,7 @@ }, { "sim":149.0, - "partner":"3jah" + "partner":"8ukb" }, { "sim":149.0, @@ -416442,6 +418168,10 @@ "sim":149.0, "partner":"6zvk" }, + { + "sim":149.0, + "partner":"3jah" + }, { "sim":149.0, "partner":"6r5q" @@ -416462,13 +418192,21 @@ "sim":149.0, "partner":"6mte" }, + { + "sim":149.0, + "partner":"7a01" + }, { "sim":149.0, "partner":"3jag" }, { "sim":149.0, - "partner":"7a01" + "partner":"6yam" + }, + { + "sim":149.0, + "partner":"7nwi" }, { "sim":149.0, @@ -416476,24 +418214,28 @@ }, { "sim":149.0, - "partner":"7nwi" + "partner":"6fec" }, { "sim":149.0, - "partner":"6olz" + "partner":"6mtb" }, { "sim":149.0, - "partner":"6gz4" + "partner":"6zvh" }, { "sim":149.0, - "partner":"7nwh" + "partner":"6gz4" }, { "sim":149.0, "partner":"6olg" }, + { + "sim":149.0, + "partner":"7nwh" + }, { "sim":149.0, "partner":"6gz3" @@ -416508,7 +418250,7 @@ }, { "sim":149.0, - "partner":"6zol" + "partner":"6olz" }, { "sim":149.0, @@ -416524,331 +418266,335 @@ }, { "sim":149.0, - "partner":"5lzv" + "partner":"6zol" }, { "sim":149.0, - "partner":"6zmw" + "partner":"4ujd" }, { "sim":149.0, - "partner":"7jqc" + "partner":"4uje" }, { "sim":149.0, - "partner":"4kzx" + "partner":"6p5j" }, { "sim":149.0, - "partner":"6ip6" + "partner":"4kzy" }, { "sim":149.0, - "partner":"6p5n" + "partner":"4ug0" }, { "sim":149.0, - "partner":"6w2t" + "partner":"5lzy" }, { "sim":149.0, - "partner":"6zxg" + "partner":"6zxh" }, { "sim":149.0, - "partner":"6zmi" + "partner":"3j7p" }, { "sim":149.0, - "partner":"4ujd" + "partner":"6hcf" }, { "sim":149.0, - "partner":"4uje" + "partner":"6z6l" }, { "sim":149.0, - "partner":"7a09" + "partner":"6zmo" }, { "sim":149.0, - "partner":"7k5i" + "partner":"6p5k" }, { "sim":149.0, - "partner":"4kzy" + "partner":"6zm7" }, { "sim":149.0, - "partner":"4ug0" + "partner":"6zme" }, { "sim":149.0, - "partner":"5lzy" + "partner":"6zon" }, { "sim":149.0, - "partner":"3j7p" + "partner":"6zp4" }, { "sim":149.0, - "partner":"6p5j" + "partner":"3j7r" }, { "sim":149.0, - "partner":"6zxh" + "partner":"4kzz" }, { "sim":149.0, - "partner":"6hcf" + "partner":"7o7z" }, { "sim":149.0, - "partner":"3j7r" + "partner":"5vyc" }, { "sim":149.0, - "partner":"4kzz" + "partner":"6hcm" }, { "sim":149.0, - "partner":"6z6l" + "partner":"6sgc" }, { "sim":149.0, - "partner":"6zmo" + "partner":"6y2l" }, { "sim":149.0, - "partner":"5vyc" + "partner":"5lzu" }, { "sim":149.0, - "partner":"6p5k" + "partner":"6ip5" }, { "sim":149.0, - "partner":"6zm7" + "partner":"5lks" }, { "sim":149.0, - "partner":"6zme" + "partner":"6g18" }, { "sim":149.0, - "partner":"6zon" + "partner":"6z6n" }, { "sim":149.0, - "partner":"6zp4" + "partner":"6zlw" }, { "sim":149.0, - "partner":"7o7z" + "partner":"5lzx" }, { "sim":149.0, - "partner":"5lzu" + "partner":"6g51" }, { "sim":149.0, - "partner":"6hcm" + "partner":"6zmt" }, { "sim":149.0, - "partner":"6sgc" + "partner":"6hcq" }, { "sim":149.0, - "partner":"6y2l" + "partner":"4ujc" }, { "sim":149.0, - "partner":"5lks" + "partner":"4v6x" }, { "sim":149.0, - "partner":"5lzx" + "partner":"6zuo" }, { "sim":149.0, - "partner":"6ip5" + "partner":"6zv6" }, { "sim":149.0, - "partner":"8vft" + "partner":"6zxd" }, { "sim":149.0, - "partner":"6g18" + "partner":"6p5i" }, { "sim":149.0, - "partner":"6z6n" + "partner":"7o7y" }, { "sim":149.0, - "partner":"6zlw" + "partner":"8vft" }, { "sim":149.0, - "partner":"4ujc" + "partner":"5flx" }, { "sim":149.0, - "partner":"4v6x" + "partner":"6d90" }, { "sim":149.0, - "partner":"6g51" + "partner":"6hcj" }, { "sim":149.0, - "partner":"6zmt" + "partner":"6ip8" }, { "sim":149.0, - "partner":"6hcq" + "partner":"5lzt" }, { "sim":149.0, - "partner":"6zuo" + "partner":"6d9j" }, { "sim":149.0, - "partner":"5flx" + "partner":"6p4g" }, { "sim":149.0, - "partner":"6zv6" + "partner":"6w2s" }, { "sim":149.0, - "partner":"6zxd" + "partner":"4d61" }, { "sim":149.0, - "partner":"7o7y" + "partner":"6g5h" }, { "sim":149.0, - "partner":"5lzt" + "partner":"6zxe" }, { "sim":149.0, - "partner":"6p5i" + "partner":"7o81" }, { "sim":149.0, - "partner":"6d90" + "partner":"5lzw" }, { "sim":149.0, - "partner":"6hcj" + "partner":"5t2c" }, { "sim":149.0, - "partner":"6ip8" + "partner":"6g5i" }, { "sim":149.0, - "partner":"4d61" + "partner":"6y57" }, { "sim":149.0, - "partner":"5lzw" + "partner":"5aj0" }, { "sim":149.0, - "partner":"5t2c" + "partner":"6ybs" }, { "sim":149.0, - "partner":"6d9j" + "partner":"6z6m" }, { "sim":149.0, - "partner":"6p4g" + "partner":"6zxf" }, { "sim":149.0, - "partner":"6w2s" + "partner":"4d5l" }, { "sim":149.0, - "partner":"7o81" + "partner":"6p4h" }, { "sim":149.0, - "partner":"6g5h" + "partner":"5lzz" }, { "sim":149.0, - "partner":"6zxe" + "partner":"6g53" }, { "sim":149.0, - "partner":"5aj0" + "partner":"6y0g" }, { "sim":149.0, - "partner":"6g5i" + "partner":"7jqb" }, { "sim":149.0, - "partner":"4d5l" + "partner":"7mdz" }, { "sim":149.0, - "partner":"6y57" + "partner":"4v5z" }, { "sim":149.0, - "partner":"5lzz" + "partner":"5lzs" }, { "sim":149.0, - "partner":"6ybs" + "partner":"6zmw" }, { "sim":149.0, - "partner":"6z6m" + "partner":"7o80" }, { "sim":149.0, - "partner":"6zxf" + "partner":"6ip6" }, { "sim":149.0, - "partner":"6p4h" + "partner":"6p5n" }, { "sim":149.0, - "partner":"4v5z" + "partner":"6w2t" }, { "sim":149.0, - "partner":"5lzs" + "partner":"6zxg" }, { "sim":149.0, - "partner":"6g53" + "partner":"7jqc" }, { "sim":149.0, - "partner":"6y0g" + "partner":"5lzv" }, { "sim":149.0, - "partner":"7jqb" + "partner":"6zmi" }, { "sim":149.0, - "partner":"7mdz" + "partner":"4kzx" }, { "sim":149.0, - "partner":"7o80" + "partner":"7a09" + }, + { + "sim":149.0, + "partner":"7k5i" }, { "sim":149.0, @@ -416872,11 +418618,11 @@ }, { "sim":148.0, - "partner":"4v6w" + "partner":"6xu8" }, { "sim":148.0, - "partner":"6xu8" + "partner":"4v6w" }, { "sim":148.0, @@ -416922,17 +418668,13 @@ "sim":147.0, "partner":"5naf" }, - { - "sim":147.0, - "partner":"6t9k" - }, { "sim":147.0, "partner":"6t9i" }, { - "sim":146.0, - "partner":"6i7o" + "sim":147.0, + "partner":"6t9k" }, { "sim":146.0, @@ -416948,19 +418690,15 @@ }, { "sim":146.0, - "partner":"1erj" + "partner":"6i7o" }, { "sim":146.0, - "partner":"4lg9" - }, - { - "sim":145.0, - "partner":"7a1g" + "partner":"1erj" }, { - "sim":145.0, - "partner":"7b7d" + "sim":146.0, + "partner":"4lg9" }, { "sim":145.0, @@ -416972,11 +418710,11 @@ }, { "sim":145.0, - "partner":"6t7t" + "partner":"8uti" }, { "sim":145.0, - "partner":"8ut0" + "partner":"6t7t" }, { "sim":145.0, @@ -416988,35 +418726,27 @@ }, { "sim":145.0, - "partner":"8uti" - }, - { - "sim":145.0, - "partner":"1trj" - }, - { - "sim":145.0, - "partner":"4v92" + "partner":"8ut0" }, { "sim":145.0, - "partner":"6wdr" + "partner":"7a1g" }, { "sim":145.0, - "partner":"4u4q" + "partner":"7b7d" }, { "sim":145.0, - "partner":"5obm" + "partner":"1trj" }, { "sim":145.0, - "partner":"4u4r" + "partner":"4v92" }, { "sim":145.0, - "partner":"5tgm" + "partner":"6wdr" }, { "sim":145.0, @@ -417032,27 +418762,27 @@ }, { "sim":145.0, - "partner":"6woo" + "partner":"4uer" }, { "sim":145.0, - "partner":"4uer" + "partner":"6gqv" }, { "sim":145.0, - "partner":"4u4u" + "partner":"6q8y" }, { "sim":145.0, - "partner":"5mei" + "partner":"4u4u" }, { "sim":145.0, - "partner":"6gqv" + "partner":"5mei" }, { "sim":145.0, - "partner":"6q8y" + "partner":"5tgm" }, { "sim":145.0, @@ -417074,6 +418804,10 @@ "sim":145.0, "partner":"5ndv" }, + { + "sim":145.0, + "partner":"6gq1" + }, { "sim":145.0, "partner":"5ndw" @@ -417088,7 +418822,7 @@ }, { "sim":145.0, - "partner":"6gq1" + "partner":"6gqb" }, { "sim":145.0, @@ -417102,10 +418836,6 @@ "sim":145.0, "partner":"5dgv" }, - { - "sim":145.0, - "partner":"6gqb" - }, { "sim":145.0, "partner":"4u50" @@ -417116,15 +418846,15 @@ }, { "sim":145.0, - "partner":"5tbw" + "partner":"6s47" }, { "sim":145.0, - "partner":"4u51" + "partner":"5tbw" }, { "sim":145.0, - "partner":"6s47" + "partner":"4u51" }, { "sim":145.0, @@ -417176,23 +418906,19 @@ }, { "sim":145.0, - "partner":"3j6y" - }, - { - "sim":145.0, - "partner":"4v8y" + "partner":"4u4q" }, { "sim":145.0, - "partner":"6zu9" + "partner":"5obm" }, { "sim":145.0, - "partner":"5juo" + "partner":"4u4r" }, { "sim":145.0, - "partner":"8t3f" + "partner":"6woo" }, { "sim":145.0, @@ -417204,11 +418930,11 @@ }, { "sim":145.0, - "partner":"5mc6" + "partner":"8t3f" }, { "sim":145.0, - "partner":"5jus" + "partner":"5mc6" }, { "sim":145.0, @@ -417216,47 +418942,47 @@ }, { "sim":145.0, - "partner":"8p4v" + "partner":"5jus" }, { "sim":145.0, - "partner":"8t2y" + "partner":"6t7i" }, { "sim":145.0, - "partner":"6t7i" + "partner":"6rbe" }, { "sim":145.0, - "partner":"8t3a" + "partner":"6t83" }, { "sim":145.0, - "partner":"6rbe" + "partner":"3j78" }, { "sim":145.0, - "partner":"6t83" + "partner":"8t2y" }, { "sim":145.0, - "partner":"8t30" + "partner":"3rfg" }, { "sim":145.0, - "partner":"3j78" + "partner":"5juu" }, { "sim":145.0, - "partner":"3rfg" + "partner":"6snt" }, { "sim":145.0, - "partner":"5juu" + "partner":"8t3a" }, { "sim":145.0, - "partner":"8t3c" + "partner":"8t30" }, { "sim":145.0, @@ -417268,15 +418994,19 @@ }, { "sim":145.0, - "partner":"6snt" + "partner":"8t3c" }, { "sim":145.0, - "partner":"8t3e" + "partner":"4v88" }, { "sim":145.0, - "partner":"4v88" + "partner":"6xir" + }, + { + "sim":145.0, + "partner":"8p4v" }, { "sim":145.0, @@ -417284,19 +419014,23 @@ }, { "sim":145.0, - "partner":"4v6i" + "partner":"6hhq" }, { "sim":145.0, - "partner":"5jup" + "partner":"8t3e" }, { "sim":145.0, - "partner":"6xir" + "partner":"4v6i" }, { "sim":145.0, - "partner":"6hhq" + "partner":"5jup" + }, + { + "sim":145.0, + "partner":"6sv4" }, { "sim":145.0, @@ -417304,7 +419038,7 @@ }, { "sim":145.0, - "partner":"8p9a" + "partner":"6z6k" }, { "sim":145.0, @@ -417312,7 +419046,7 @@ }, { "sim":145.0, - "partner":"6sv4" + "partner":"3j77" }, { "sim":145.0, @@ -417320,15 +419054,15 @@ }, { "sim":145.0, - "partner":"6z6k" + "partner":"5jut" }, { "sim":145.0, - "partner":"3j77" + "partner":"6fai" }, { "sim":145.0, - "partner":"5jut" + "partner":"6zu9" }, { "sim":145.0, @@ -417336,35 +419070,31 @@ }, { "sim":145.0, - "partner":"6fai" + "partner":"8p9a" }, { "sim":145.0, - "partner":"8t3b" + "partner":"3j6y" }, { "sim":145.0, - "partner":"8t3d" - }, - { - "sim":143.0, - "partner":"6f3t" + "partner":"4v8y" }, { - "sim":143.0, - "partner":"7eg9" + "sim":145.0, + "partner":"8t3b" }, { - "sim":143.0, - "partner":"7enc" + "sim":145.0, + "partner":"5juo" }, { - "sim":143.0, - "partner":"7egj" + "sim":145.0, + "partner":"8t3d" }, { "sim":143.0, - "partner":"7ena" + "partner":"6f3t" }, { "sim":143.0, @@ -417410,6 +419140,22 @@ "sim":143.0, "partner":"7ege" }, + { + "sim":143.0, + "partner":"7eg9" + }, + { + "sim":143.0, + "partner":"7enc" + }, + { + "sim":143.0, + "partner":"7egj" + }, + { + "sim":143.0, + "partner":"7ena" + }, { "sim":143.0, "partner":"3sfz" @@ -417528,83 +419274,83 @@ }, { "sim":131.0, - "partner":"5ukk" + "partner":"8wgb" }, { "sim":131.0, - "partner":"7dfl" + "partner":"5ukl" }, { "sim":131.0, - "partner":"7k7z" + "partner":"6gdg" }, { "sim":131.0, - "partner":"7jjo" + "partner":"4mk0" }, { "sim":131.0, - "partner":"5ukl" + "partner":"5he0" }, { "sim":131.0, - "partner":"6gdg" + "partner":"5he1" }, { "sim":131.0, - "partner":"4mk0" + "partner":"7k7l" }, { "sim":131.0, - "partner":"5he0" + "partner":"6g79" }, { "sim":131.0, - "partner":"5he1" + "partner":"5he2" }, { "sim":131.0, - "partner":"7k7l" + "partner":"5he3" }, { "sim":131.0, - "partner":"5he2" + "partner":"7dfl" }, { "sim":131.0, - "partner":"6g79" + "partner":"5ukk" }, { "sim":131.0, - "partner":"8wgb" + "partner":"7k7z" }, { "sim":131.0, - "partner":"5he3" + "partner":"7jjo" }, { "sim":131.0, - "partner":"6wi9" + "partner":"7dhr" }, { "sim":131.0, - "partner":"7o7f" + "partner":"8k4s" }, { "sim":131.0, - "partner":"4kfm" + "partner":"5kdo" }, { "sim":131.0, - "partner":"6x18" + "partner":"6pcv" }, { "sim":131.0, - "partner":"5kdo" + "partner":"6vms" }, { "sim":131.0, - "partner":"7dhr" + "partner":"6x19" }, { "sim":131.0, @@ -417612,19 +419358,19 @@ }, { "sim":131.0, - "partner":"6pcv" + "partner":"8p15" }, { "sim":131.0, - "partner":"6vms" + "partner":"6niy" }, { "sim":131.0, - "partner":"6x19" + "partner":"7f1q" }, { "sim":131.0, - "partner":"6niy" + "partner":"8vve" }, { "sim":131.0, @@ -417632,15 +419378,19 @@ }, { "sim":131.0, - "partner":"7f1q" + "partner":"7lci" }, { "sim":131.0, - "partner":"7lci" + "partner":"7f1r" }, { "sim":131.0, - "partner":"8k4s" + "partner":"8vvf" + }, + { + "sim":131.0, + "partner":"6c2y" }, { "sim":131.0, @@ -417648,27 +419398,27 @@ }, { "sim":131.0, - "partner":"1gg2" + "partner":"6kpf" }, { "sim":131.0, - "partner":"3pvu" + "partner":"8zjg" }, { "sim":131.0, - "partner":"4pnk" + "partner":"3pvu" }, { "sim":131.0, - "partner":"6c2y" + "partner":"4pnk" }, { "sim":131.0, - "partner":"7f1r" + "partner":"7bz2" }, { "sim":131.0, - "partner":"8p12" + "partner":"7f1s" }, { "sim":131.0, @@ -417680,7 +419430,7 @@ }, { "sim":131.0, - "partner":"6kpf" + "partner":"7dhi" }, { "sim":131.0, @@ -417688,27 +419438,27 @@ }, { "sim":131.0, - "partner":"7bz2" + "partner":"6whc" }, { "sim":131.0, - "partner":"1gp2" + "partner":"8vvg" }, { "sim":131.0, - "partner":"5wg3" + "partner":"1gg2" }, { "sim":131.0, - "partner":"6whc" + "partner":"5wg3" }, { "sim":131.0, - "partner":"7dhi" + "partner":"7ki1" }, { "sim":131.0, - "partner":"7f1s" + "partner":"7mbx" }, { "sim":131.0, @@ -417716,11 +419466,7 @@ }, { "sim":131.0, - "partner":"7ki1" - }, - { - "sim":131.0, - "partner":"7mbx" + "partner":"6wzg" }, { "sim":131.0, @@ -417732,7 +419478,7 @@ }, { "sim":131.0, - "partner":"8p13" + "partner":"1gp2" }, { "sim":131.0, @@ -417742,10 +419488,6 @@ "sim":131.0, "partner":"5wg4" }, - { - "sim":131.0, - "partner":"6wzg" - }, { "sim":131.0, "partner":"1xhm" @@ -417756,11 +419498,11 @@ }, { "sim":131.0, - "partner":"3krw" + "partner":"6qno" }, { "sim":131.0, - "partner":"5wg5" + "partner":"6rmv" }, { "sim":131.0, @@ -417772,15 +419514,19 @@ }, { "sim":131.0, - "partner":"6qno" + "partner":"8p12" }, { "sim":131.0, - "partner":"6rmv" + "partner":"8xqe" }, { "sim":131.0, - "partner":"3krx" + "partner":"3krw" + }, + { + "sim":131.0, + "partner":"5wg5" }, { "sim":131.0, @@ -417788,7 +419534,11 @@ }, { "sim":131.0, - "partner":"8p15" + "partner":"8z7j" + }, + { + "sim":131.0, + "partner":"3krx" }, { "sim":131.0, @@ -417796,7 +419546,27 @@ }, { "sim":131.0, - "partner":"6m1h" + "partner":"6wi9" + }, + { + "sim":131.0, + "partner":"6x18" + }, + { + "sim":131.0, + "partner":"7o7f" + }, + { + "sim":131.0, + "partner":"8p13" + }, + { + "sim":131.0, + "partner":"8xqf" + }, + { + "sim":131.0, + "partner":"4kfm" }, { "sim":131.0, @@ -417804,11 +419574,11 @@ }, { "sim":131.0, - "partner":"5tdh" + "partner":"6m1h" }, { "sim":131.0, - "partner":"6xbk" + "partner":"5tdh" }, { "sim":131.0, @@ -417832,11 +419602,11 @@ }, { "sim":131.0, - "partner":"6dde" + "partner":"7db6" }, { "sim":131.0, - "partner":"7db6" + "partner":"6dde" }, { "sim":131.0, @@ -417848,28 +419618,16 @@ }, { "sim":131.0, - "partner":"6nbi" - }, - { - "sim":131.0, - "partner":"6oij" - }, - { - "sim":131.0, - "partner":"7duq" + "partner":"6xbk" }, { "sim":131.0, - "partner":"7e32" + "partner":"7dur" }, { "sim":131.0, "partner":"6oik" }, - { - "sim":131.0, - "partner":"7dur" - }, { "sim":131.0, "partner":"7e33" @@ -417882,6 +419640,10 @@ "sim":131.0, "partner":"7evm" }, + { + "sim":131.0, + "partner":"7e2x" + }, { "sim":131.0, "partner":"7jhj" @@ -417896,15 +419658,15 @@ }, { "sim":131.0, - "partner":"7e2x" + "partner":"7cmu" }, { "sim":131.0, - "partner":"6pb0" + "partner":"7e2y" }, { "sim":131.0, - "partner":"7cmu" + "partner":"6pb0" }, { "sim":131.0, @@ -417912,11 +419674,11 @@ }, { "sim":131.0, - "partner":"7e2y" + "partner":"7exd" }, { "sim":131.0, - "partner":"7exd" + "partner":"7e14" }, { "sim":131.0, @@ -417924,7 +419686,7 @@ }, { "sim":131.0, - "partner":"7e14" + "partner":"7e2z" }, { "sim":131.0, @@ -417932,15 +419694,27 @@ }, { "sim":131.0, - "partner":"7e2z" + "partner":"6pb1" }, { "sim":131.0, - "partner":"6pb1" + "partner":"6crk" }, { "sim":131.0, - "partner":"6crk" + "partner":"6nbi" + }, + { + "sim":131.0, + "partner":"7duq" + }, + { + "sim":131.0, + "partner":"7e32" + }, + { + "sim":131.0, + "partner":"6oij" }, { "sim":131.0, @@ -417960,11 +419734,11 @@ }, { "sim":131.0, - "partner":"7jvr" + "partner":"7ckz" }, { "sim":131.0, - "partner":"7ckz" + "partner":"7jvr" }, { "sim":131.0, @@ -417980,47 +419754,43 @@ }, { "sim":131.0, - "partner":"6d9h" - }, - { - "sim":131.0, - "partner":"6p9x" + "partner":"6vcb" }, { "sim":131.0, - "partner":"6uva" + "partner":"7joz" }, { "sim":131.0, - "partner":"6k42" + "partner":"6p9y" }, { "sim":131.0, - "partner":"6xox" + "partner":"8xx3" }, { "sim":131.0, - "partner":"6vcb" + "partner":"5ukm" }, { "sim":131.0, - "partner":"7joz" + "partner":"6e3y" }, { "sim":131.0, - "partner":"5ukm" + "partner":"7ld3" }, { "sim":131.0, - "partner":"6p9y" + "partner":"6m8s" }, { "sim":131.0, - "partner":"7ld3" + "partner":"6ni3" }, { "sim":131.0, - "partner":"6e3y" + "partner":"7c2e" }, { "sim":131.0, @@ -418028,15 +419798,15 @@ }, { "sim":131.0, - "partner":"6m8s" + "partner":"8xx7" }, { "sim":131.0, - "partner":"6ni3" + "partner":"8xwv" }, { "sim":131.0, - "partner":"7c2e" + "partner":"8xxh" }, { "sim":131.0, @@ -418050,13 +419820,21 @@ "sim":131.0, "partner":"6orv" }, + { + "sim":131.0, + "partner":"8tyw" + }, { "sim":131.0, "partner":"6uus" }, { "sim":131.0, - "partner":"8tyw" + "partner":"8jzp" + }, + { + "sim":131.0, + "partner":"8xxx" }, { "sim":131.0, @@ -418064,7 +419842,31 @@ }, { "sim":131.0, - "partner":"7e9h" + "partner":"8xxr" + }, + { + "sim":131.0, + "partner":"6d9h" + }, + { + "sim":131.0, + "partner":"6p9x" + }, + { + "sim":131.0, + "partner":"6uva" + }, + { + "sim":131.0, + "partner":"8xx6" + }, + { + "sim":131.0, + "partner":"6k42" + }, + { + "sim":131.0, + "partner":"6xox" }, { "sim":131.0, @@ -418104,15 +419906,15 @@ }, { "sim":131.0, - "partner":"3sn6" + "partner":"7e9g" }, { "sim":131.0, - "partner":"7e9g" + "partner":"7ezm" }, { "sim":131.0, - "partner":"7ezm" + "partner":"3sn6" }, { "sim":131.0, @@ -418122,6 +419924,10 @@ "sim":131.0, "partner":"6ot0" }, + { + "sim":131.0, + "partner":"7e9h" + }, { "sim":131.0, "partner":"7ljc" @@ -418152,15 +419958,15 @@ }, { "sim":131.0, - "partner":"7ckx" + "partner":"8x3l" }, { "sim":131.0, - "partner":"7crh" + "partner":"7ckx" }, { "sim":131.0, - "partner":"8x3l" + "partner":"7crh" }, { "sim":131.0, @@ -418170,21 +419976,17 @@ "sim":131.0, "partner":"7aue" }, - { - "sim":131.0, - "partner":"7cx2" - }, { "sim":131.0, "partner":"6wpw" }, { "sim":131.0, - "partner":"8rql" + "partner":"7cx3" }, { "sim":131.0, - "partner":"7cx3" + "partner":"8rql" }, { "sim":131.0, @@ -418208,7 +420010,7 @@ }, { "sim":131.0, - "partner":"7l0r" + "partner":"7cx2" }, { "sim":131.0, @@ -418222,6 +420024,10 @@ "sim":131.0, "partner":"7l0q" }, + { + "sim":131.0, + "partner":"7l0r" + }, { "sim":131.0, "partner":"7bb6" @@ -418248,11 +420054,11 @@ }, { "sim":130.0, - "partner":"1got" + "partner":"2trc" }, { "sim":130.0, - "partner":"2trc" + "partner":"1got" }, { "sim":130.0, @@ -418276,47 +420082,59 @@ }, { "sim":130.0, - "partner":"7f4h" + "partner":"8zfz" }, { "sim":130.0, - "partner":"7f9y" + "partner":"7f4d" }, { "sim":130.0, - "partner":"7f16" + "partner":"8vhf" }, { "sim":130.0, - "partner":"7dw9" + "partner":"7f9z" }, { "sim":130.0, - "partner":"7f4d" + "partner":"7f4i" }, { "sim":130.0, - "partner":"7f9z" + "partner":"7f4f" }, { "sim":130.0, - "partner":"7f4i" + "partner":"7d68" }, { "sim":130.0, - "partner":"7d68" + "partner":"7dty" }, { "sim":130.0, - "partner":"7f4f" + "partner":"7f4h" }, { "sim":130.0, - "partner":"8vhf" + "partner":"7f9y" }, { "sim":130.0, - "partner":"7dty" + "partner":"7f16" + }, + { + "sim":130.0, + "partner":"7dw9" + }, + { + "sim":130.0, + "partner":"8wwi" + }, + { + "sim":130.0, + "partner":"8wwj" }, { "sim":130.0, @@ -418340,15 +420158,11 @@ }, { "sim":130.0, - "partner":"8wwi" - }, - { - "sim":130.0, - "partner":"8wwj" + "partner":"6vn7" }, { "sim":130.0, - "partner":"6vn7" + "partner":"8jsr" }, { "sim":130.0, @@ -418356,11 +420170,11 @@ }, { "sim":129.0, - "partner":"4v5o" + "partner":"4bts" }, { "sim":129.0, - "partner":"4bts" + "partner":"4v5o" }, { "sim":129.0, @@ -418408,35 +420222,35 @@ }, { "sim":128.0, - "partner":"3jam" + "partner":"6fyx" }, { "sim":128.0, - "partner":"3jap" + "partner":"6uz7" }, { "sim":128.0, - "partner":"6fyy" + "partner":"3j80" }, { "sim":128.0, - "partner":"3j80" + "partner":"3j81" }, { "sim":128.0, - "partner":"6fyx" + "partner":"8s8k" }, { "sim":128.0, - "partner":"6uz7" + "partner":"3jam" }, { "sim":128.0, - "partner":"3j81" + "partner":"3jap" }, { "sim":128.0, - "partner":"8s8k" + "partner":"6fyy" }, { "sim":128.0, @@ -418458,18 +420272,6 @@ "sim":125.0, "partner":"2ynp" }, - { - "sim":125.0, - "partner":"6ke6" - }, - { - "sim":125.0, - "partner":"6lqq" - }, - { - "sim":125.0, - "partner":"7ajt" - }, { "sim":125.0, "partner":"6lqr" @@ -418532,7 +420334,15 @@ }, { "sim":125.0, - "partner":"6rxy" + "partner":"6ke6" + }, + { + "sim":125.0, + "partner":"6lqq" + }, + { + "sim":125.0, + "partner":"7ajt" }, { "sim":125.0, @@ -418558,6 +420368,10 @@ "sim":125.0, "partner":"6rxt" }, + { + "sim":125.0, + "partner":"6rxy" + }, { "sim":124.0, "partner":"4j86" @@ -418622,10 +420436,6 @@ "sim":120.0, "partner":"7dco" }, - { - "sim":120.0, - "partner":"7b9v" - }, { "sim":120.0, "partner":"6bk8" @@ -418636,11 +420446,11 @@ }, { "sim":120.0, - "partner":"5wsg" + "partner":"6j6q" }, { "sim":120.0, - "partner":"6j6q" + "partner":"5wsg" }, { "sim":120.0, @@ -418654,6 +420464,10 @@ "sim":120.0, "partner":"5y88" }, + { + "sim":120.0, + "partner":"6j6g" + }, { "sim":120.0, "partner":"5gm6" @@ -418664,7 +420478,7 @@ }, { "sim":120.0, - "partner":"6j6g" + "partner":"6j6n" }, { "sim":120.0, @@ -418672,23 +420486,23 @@ }, { "sim":120.0, - "partner":"6j6n" + "partner":"5lqw" }, { "sim":120.0, - "partner":"5lqw" + "partner":"6j6h" }, { "sim":120.0, - "partner":"5mps" + "partner":"7b9v" }, { "sim":120.0, - "partner":"5ylz" + "partner":"5mps" }, { "sim":120.0, - "partner":"6j6h" + "partner":"5ylz" }, { "sim":116.0, @@ -418702,10 +420516,6 @@ "sim":114.0, "partner":"2pbi" }, - { - "sim":113.0, - "partner":"5nzv" - }, { "sim":113.0, "partner":"5nzt" @@ -418742,6 +420552,10 @@ "sim":113.0, "partner":"5a1w" }, + { + "sim":113.0, + "partner":"5nzv" + }, { "sim":112.0, "partner":"4v7e" @@ -418792,27 +420606,27 @@ }, { "sim":104.0, - "partner":"5khr" + "partner":"6q6h" }, { "sim":104.0, - "partner":"6f0x" + "partner":"6q6g" }, { "sim":104.0, - "partner":"6q6h" + "partner":"5khu" }, { "sim":104.0, - "partner":"5khu" + "partner":"5g04" }, { "sim":104.0, - "partner":"6q6g" + "partner":"6f0x" }, { "sim":104.0, - "partner":"5g04" + "partner":"5khr" }, { "sim":102.0, @@ -418844,11 +420658,11 @@ }, { "sim":99.0, - "partner":"1pev" + "partner":"1nr0" }, { "sim":99.0, - "partner":"1nr0" + "partner":"1pev" }, { "sim":96.0, @@ -418862,25 +420676,17 @@ "sim":94.0, "partner":"5n4a" }, - { - "sim":93.0, - "partner":"5flc" - }, - { - "sim":93.0, - "partner":"6sb0" - }, { "sim":93.0, "partner":"4jsv" }, { "sim":93.0, - "partner":"5h64" + "partner":"7pea" }, { "sim":93.0, - "partner":"7pea" + "partner":"5h64" }, { "sim":93.0, @@ -418928,11 +420734,11 @@ }, { "sim":93.0, - "partner":"4jt6" + "partner":"6zwo" }, { "sim":93.0, - "partner":"6zwo" + "partner":"4jt6" }, { "sim":93.0, @@ -418952,55 +420758,63 @@ }, { "sim":93.0, - "partner":"5wbu" + "partner":"6sb0" + }, + { + "sim":93.0, + "partner":"5flc" }, { "sim":93.0, "partner":"5wby" }, + { + "sim":93.0, + "partner":"5wbu" + }, { "sim":92.0, "partner":"4bzj" }, { "sim":92.0, - "partner":"3mzk" + "partner":"3mzl" }, { "sim":92.0, - "partner":"6zg5" + "partner":"6zg6" }, { "sim":92.0, - "partner":"4xmm" + "partner":"3iko" }, { "sim":92.0, - "partner":"3mzl" + "partner":"4xmn" }, { "sim":92.0, - "partner":"3iko" + "partner":"2pm6" }, { "sim":92.0, - "partner":"6zg6" + "partner":"6zl0" }, { "sim":92.0, - "partner":"4xmn" + "partner":"4bzk" }, { "sim":92.0, - "partner":"2pm6" + "partner":"6zg5" }, { "sim":92.0, - "partner":"6zl0" + "partner":"3mzk" }, { "sim":92.0, - "partner":"4bzk" + "partner":"4xmm" }, { "sim":92.0, @@ -419028,11 +420842,11 @@ }, { "sim":90.0, - "partner":"6uh5" + "partner":"6ugm" }, { "sim":90.0, - "partner":"6ugm" + "partner":"6uh5" }, { "sim":90.0, @@ -419096,11 +420910,11 @@ }, { "sim":69.0, - "partner":"5m2n" + "partner":"6qk7" }, { "sim":69.0, - "partner":"6qk7" + "partner":"5m2n" }, { "sim":69.0, @@ -419208,11 +421022,11 @@ }, { "sim":56.0, - "partner":"7m05" + "partner":"6v0n" }, { "sim":56.0, - "partner":"6v0n" + "partner":"7m05" }, { "sim":56.0, @@ -419240,63 +421054,63 @@ }, { "sim":56.0, - "partner":"4x63" + "partner":"4x60" }, { "sim":56.0, - "partner":"7kid" + "partner":"4x61" }, { "sim":56.0, - "partner":"6uxx" + "partner":"5c9z" }, { "sim":56.0, - "partner":"6uxy" + "partner":"5emj" }, { "sim":56.0, - "partner":"4x60" + "partner":"6k1s" }, { "sim":56.0, - "partner":"4x61" + "partner":"7l1g" }, { "sim":56.0, - "partner":"5c9z" + "partner":"5emk" }, { "sim":56.0, - "partner":"5emj" + "partner":"5eml" }, { "sim":56.0, - "partner":"5emk" + "partner":"7kib" }, { "sim":56.0, - "partner":"6k1s" + "partner":"5emm" }, { "sim":56.0, - "partner":"7l1g" + "partner":"7kic" }, { "sim":56.0, - "partner":"5eml" + "partner":"6uxx" }, { "sim":56.0, - "partner":"7kib" + "partner":"7kid" }, { "sim":56.0, - "partner":"5emm" + "partner":"4x63" }, { "sim":56.0, - "partner":"7kic" + "partner":"6uxy" }, { "sim":56.0, @@ -419400,67 +421214,67 @@ "synthetic construct" ], "keywords":[ - "stability", - "diverse", + "templates", + "repeats", "analysis", - "evolution", - "consisting", - "constraints", - "functional", - "proteins", - "large", - "reveals", - "architecture", - "multiple", - "unique", - "common", - "showing", - "study", - "formula", - "characterized", - "template", - "tools", - "artificial", - "fold", - "test", - "see", + "engineering", "engineered", + "design", + "characterized", + "perfectly", + "diverse", + "help", + "geometrical", "used", - "highly", - "approaches", - "useful", "suggests", + "functional", + "natural", + "multiple", + "approaches", + "based", + "permutation", + "consisting", + "discovered", + "fold", + "text", + "symmetrical", + "template", + "protein", "nature", + "useful", + "study", + "stability", + "showing", + "proteins", + "large", + "sequential", "symmetric", - "help", - "engineering", - "geometrical", + "artificial", + "tools", "systematic", + "architecture", + "see", + "constraints", "far", - "based", - "design", - "symmetrical", - "variation", - "protein", - "using", - "templates", - "natural", - "perfectly", - "discovered", - "describe", - "sequence", - "repeats", + "test", + "highly", "constraint", - "text", + "sequence", + "common", + "reveals", "circular", + "contain", + "created", + "evolution", + "formula", "monomer", - "computational", + "describe", "effects", - "could", - "permutation", - "sequential", - "contain", - "created" + "unique", + "variation", + "computational", + "using", + "could" ], "release_date":"2021-09-22", "publication":"\"Structure and stability of the designer protein WRAP-T and its permutants\", Sci Rep, 11, 18867-18867", @@ -419509,19 +421323,19 @@ }, { "sim":243.0, - "partner":"6g6n" + "partner":"6g6m" }, { "sim":243.0, - "partner":"6y7p" + "partner":"6y7n" }, { "sim":243.0, - "partner":"6y7n" + "partner":"6g6n" }, { "sim":243.0, - "partner":"6g6m" + "partner":"6y7p" }, { "sim":241.0, @@ -419551,15 +421365,15 @@ }, { "sim":209.0, - "partner":"2h9n" + "partner":"2o9k" }, { "sim":209.0, - "partner":"2o9k" + "partner":"2h9m" }, { "sim":209.0, - "partner":"2h9m" + "partner":"2h9n" }, { "sim":209.0, @@ -419579,51 +421393,47 @@ }, { "sim":208.0, - "partner":"6u8l" - }, - { - "sim":208.0, - "partner":"6u5m" + "partner":"6uj4" }, { "sim":208.0, - "partner":"6uhy" + "partner":"6uif" }, { "sim":208.0, - "partner":"6uoz" + "partner":"6u5y" }, { "sim":208.0, - "partner":"6uhz" + "partner":"6uik" }, { "sim":208.0, - "partner":"6uj4" + "partner":"6u8o" }, { "sim":208.0, - "partner":"6uif" + "partner":"6dy7" }, { "sim":208.0, - "partner":"6u5y" + "partner":"6u8l" }, { "sim":208.0, - "partner":"6uik" + "partner":"6u5m" }, { "sim":208.0, - "partner":"6u8o" + "partner":"6uhy" }, { "sim":208.0, - "partner":"6dy7" + "partner":"6uoz" }, { "sim":208.0, - "partner":"6pgf" + "partner":"6uhz" }, { "sim":208.0, @@ -419663,23 +421473,19 @@ }, { "sim":208.0, - "partner":"6iam" - }, - { - "sim":208.0, - "partner":"6byn" + "partner":"6pgf" }, { "sim":208.0, - "partner":"2g99" + "partner":"6iam" }, { "sim":208.0, - "partner":"5vfc" + "partner":"6byn" }, { "sim":208.0, - "partner":"6u6w" + "partner":"2g99" }, { "sim":208.0, @@ -419695,11 +421501,11 @@ }, { "sim":208.0, - "partner":"2h6k" + "partner":"6u6w" }, { "sim":208.0, - "partner":"5eap" + "partner":"5vfc" }, { "sim":208.0, @@ -419779,19 +421585,15 @@ }, { "sim":208.0, - "partner":"6ofz" - }, - { - "sim":208.0, - "partner":"6ujj" + "partner":"2h6k" }, { "sim":208.0, - "partner":"6e1y" + "partner":"5eap" }, { "sim":208.0, - "partner":"6ujl" + "partner":"6dai" }, { "sim":208.0, @@ -419799,11 +421601,11 @@ }, { "sim":208.0, - "partner":"6w5n" + "partner":"6pwv" }, { "sim":208.0, - "partner":"6dai" + "partner":"6dak" }, { "sim":208.0, @@ -419811,27 +421613,27 @@ }, { "sim":208.0, - "partner":"6pwv" + "partner":"6e22" }, { "sim":208.0, - "partner":"6dak" + "partner":"6wjq" }, { "sim":208.0, - "partner":"6e22" + "partner":"6e23" }, { "sim":208.0, - "partner":"6wjq" + "partner":"6oi0" }, { "sim":208.0, - "partner":"6e23" + "partner":"6oi1" }, { "sim":208.0, - "partner":"6oi0" + "partner":"6oi2" }, { "sim":208.0, @@ -419839,7 +421641,7 @@ }, { "sim":208.0, - "partner":"6oi1" + "partner":"6oi3" }, { "sim":208.0, @@ -419851,15 +421653,15 @@ }, { "sim":208.0, - "partner":"6oi2" + "partner":"6ujh" }, { "sim":208.0, - "partner":"6oi3" + "partner":"6pww" }, { "sim":208.0, - "partner":"6ujh" + "partner":"6dar" }, { "sim":208.0, @@ -419867,35 +421669,47 @@ }, { "sim":208.0, - "partner":"6pww" + "partner":"6das" }, { "sim":208.0, - "partner":"6dar" + "partner":"7dno" }, { "sim":208.0, - "partner":"6das" + "partner":"6w5m" }, { "sim":208.0, - "partner":"6w5m" + "partner":"6ucs" }, { "sim":208.0, - "partner":"7dno" + "partner":"6d9x" }, { "sim":208.0, - "partner":"6ucs" + "partner":"6w5i" }, { "sim":208.0, - "partner":"6d9x" + "partner":"6ofz" }, { "sim":208.0, - "partner":"6w5i" + "partner":"6ujj" + }, + { + "sim":208.0, + "partner":"6e1y" + }, + { + "sim":208.0, + "partner":"6ujl" + }, + { + "sim":208.0, + "partner":"6w5n" }, { "sim":208.0, @@ -419981,14 +421795,6 @@ "sim":208.0, "partner":"2h9l" }, - { - "sim":208.0, - "partner":"2xl3" - }, - { - "sim":208.0, - "partner":"7cfp" - }, { "sim":208.0, "partner":"6kiw" @@ -420017,6 +421823,14 @@ "sim":208.0, "partner":"6kix" }, + { + "sim":208.0, + "partner":"2xl3" + }, + { + "sim":208.0, + "partner":"7cfp" + }, { "sim":208.0, "partner":"2gnq" @@ -420058,12 +421872,12 @@ "partner":"1vyh" }, { - "sim":183.0, - "partner":"4wjv" + "sim":192.0, + "partner":"8rl2" }, { "sim":183.0, - "partner":"7btb" + "partner":"4wjv" }, { "sim":183.0, @@ -420075,35 +421889,39 @@ }, { "sim":183.0, - "partner":"3jct" + "partner":"7bt6" }, { "sim":183.0, - "partner":"5jcs" + "partner":"6ft6" }, { "sim":183.0, - "partner":"7bt6" + "partner":"6ylh" }, { "sim":183.0, - "partner":"6ft6" + "partner":"3jct" }, { "sim":183.0, - "partner":"6ylh" + "partner":"5jcs" }, { "sim":183.0, "partner":"6m62" }, + { + "sim":183.0, + "partner":"6ylg" + }, { "sim":183.0, "partner":"4wju" }, { "sim":183.0, - "partner":"6ylg" + "partner":"7btb" }, { "sim":181.0, @@ -420119,35 +421937,31 @@ }, { "sim":171.0, - "partner":"7abi" + "partner":"6ff7" }, { "sim":171.0, "partner":"6ah0" }, - { - "sim":171.0, - "partner":"6ff7" - }, { "sim":171.0, "partner":"6ahd" }, { "sim":171.0, - "partner":"5xjc" + "partner":"6icz" }, { "sim":171.0, - "partner":"5z57" + "partner":"5xjc" }, { "sim":171.0, - "partner":"6icz" + "partner":"7abg" }, { "sim":171.0, - "partner":"7abg" + "partner":"5z57" }, { "sim":171.0, @@ -420159,19 +421973,23 @@ }, { "sim":171.0, - "partner":"5z56" + "partner":"7dvq" }, { "sim":171.0, "partner":"6qw6" }, + { + "sim":171.0, + "partner":"5z56" + }, { "sim":171.0, "partner":"5mqf" }, { "sim":171.0, - "partner":"7dvq" + "partner":"6qx9" }, { "sim":171.0, @@ -420183,15 +422001,15 @@ }, { "sim":171.0, - "partner":"6qx9" + "partner":"5z58" }, { "sim":171.0, - "partner":"5z58" + "partner":"6id1" }, { "sim":171.0, - "partner":"6id1" + "partner":"7abi" }, { "sim":165.0, @@ -420239,11 +422057,11 @@ }, { "sim":158.0, - "partner":"4v6w" + "partner":"6xu8" }, { "sim":158.0, - "partner":"6xu8" + "partner":"4v6w" }, { "sim":157.0, @@ -420261,10 +422079,6 @@ "sim":156.0, "partner":"6zvj" }, - { - "sim":156.0, - "partner":"6ole" - }, { "sim":156.0, "partner":"6om7" @@ -420283,28 +422097,12 @@ }, { "sim":156.0, - "partner":"6yam" - }, - { - "sim":156.0, - "partner":"6fec" - }, - { - "sim":156.0, - "partner":"6mtb" - }, - { - "sim":156.0, - "partner":"6zvh" + "partner":"6ole" }, { "sim":156.0, "partner":"3jaj" }, - { - "sim":156.0, - "partner":"8ukb" - }, { "sim":156.0, "partner":"6r6g" @@ -420319,11 +422117,11 @@ }, { "sim":156.0, - "partner":"3jai" + "partner":"6r6p" }, { "sim":156.0, - "partner":"6r6p" + "partner":"3jai" }, { "sim":156.0, @@ -420339,7 +422137,7 @@ }, { "sim":156.0, - "partner":"3jah" + "partner":"8ukb" }, { "sim":156.0, @@ -420349,6 +422147,10 @@ "sim":156.0, "partner":"6zvk" }, + { + "sim":156.0, + "partner":"3jah" + }, { "sim":156.0, "partner":"6r5q" @@ -420369,13 +422171,21 @@ "sim":156.0, "partner":"6mte" }, + { + "sim":156.0, + "partner":"7a01" + }, { "sim":156.0, "partner":"3jag" }, { "sim":156.0, - "partner":"7a01" + "partner":"6yam" + }, + { + "sim":156.0, + "partner":"7nwi" }, { "sim":156.0, @@ -420383,24 +422193,28 @@ }, { "sim":156.0, - "partner":"7nwi" + "partner":"6fec" }, { "sim":156.0, - "partner":"6olz" + "partner":"6mtb" }, { "sim":156.0, - "partner":"6gz4" + "partner":"6zvh" }, { "sim":156.0, - "partner":"7nwh" + "partner":"6gz4" }, { "sim":156.0, "partner":"6olg" }, + { + "sim":156.0, + "partner":"7nwh" + }, { "sim":156.0, "partner":"6gz3" @@ -420415,7 +422229,7 @@ }, { "sim":156.0, - "partner":"6zol" + "partner":"6olz" }, { "sim":156.0, @@ -420431,331 +422245,335 @@ }, { "sim":156.0, - "partner":"5lzv" + "partner":"6zol" }, { "sim":156.0, - "partner":"6zmw" + "partner":"4ujd" }, { "sim":156.0, - "partner":"7jqc" + "partner":"4uje" }, { "sim":156.0, - "partner":"4kzx" + "partner":"6p5j" }, { "sim":156.0, - "partner":"6ip6" + "partner":"4kzy" }, { "sim":156.0, - "partner":"6p5n" + "partner":"4ug0" }, { "sim":156.0, - "partner":"6w2t" + "partner":"5lzy" }, { "sim":156.0, - "partner":"6zxg" + "partner":"6zxh" }, { "sim":156.0, - "partner":"6zmi" + "partner":"3j7p" }, { "sim":156.0, - "partner":"4ujd" + "partner":"6hcf" }, { "sim":156.0, - "partner":"4uje" + "partner":"6z6l" }, { "sim":156.0, - "partner":"7a09" + "partner":"6zmo" }, { "sim":156.0, - "partner":"7k5i" + "partner":"6p5k" }, { "sim":156.0, - "partner":"4kzy" + "partner":"6zm7" }, { "sim":156.0, - "partner":"4ug0" + "partner":"6zme" }, { "sim":156.0, - "partner":"5lzy" + "partner":"6zon" }, { "sim":156.0, - "partner":"3j7p" + "partner":"6zp4" }, { "sim":156.0, - "partner":"6p5j" + "partner":"3j7r" }, { "sim":156.0, - "partner":"6zxh" + "partner":"4kzz" }, { "sim":156.0, - "partner":"6hcf" + "partner":"7o7z" }, { "sim":156.0, - "partner":"3j7r" + "partner":"5vyc" }, { "sim":156.0, - "partner":"4kzz" + "partner":"6hcm" }, { "sim":156.0, - "partner":"6z6l" + "partner":"6sgc" }, { "sim":156.0, - "partner":"6zmo" + "partner":"6y2l" }, { "sim":156.0, - "partner":"5vyc" + "partner":"5lzu" }, { "sim":156.0, - "partner":"6p5k" + "partner":"6ip5" }, { "sim":156.0, - "partner":"6zm7" + "partner":"5lks" }, { "sim":156.0, - "partner":"6zme" + "partner":"6g18" }, { "sim":156.0, - "partner":"6zon" + "partner":"6z6n" }, { "sim":156.0, - "partner":"6zp4" + "partner":"6zlw" }, { "sim":156.0, - "partner":"7o7z" + "partner":"5lzx" }, { "sim":156.0, - "partner":"5lzu" + "partner":"6g51" }, { "sim":156.0, - "partner":"6hcm" + "partner":"6zmt" }, { "sim":156.0, - "partner":"6sgc" + "partner":"6hcq" }, { "sim":156.0, - "partner":"6y2l" + "partner":"4ujc" }, { "sim":156.0, - "partner":"5lks" + "partner":"4v6x" }, { "sim":156.0, - "partner":"5lzx" + "partner":"6zuo" }, { "sim":156.0, - "partner":"6ip5" + "partner":"6zv6" }, { "sim":156.0, - "partner":"8vft" + "partner":"6zxd" }, { "sim":156.0, - "partner":"6g18" + "partner":"6p5i" }, { "sim":156.0, - "partner":"6z6n" + "partner":"7o7y" }, { "sim":156.0, - "partner":"6zlw" + "partner":"8vft" }, { "sim":156.0, - "partner":"4ujc" + "partner":"5flx" }, { "sim":156.0, - "partner":"4v6x" + "partner":"6d90" }, { "sim":156.0, - "partner":"6g51" + "partner":"6hcj" }, { "sim":156.0, - "partner":"6zmt" + "partner":"6ip8" }, { "sim":156.0, - "partner":"6hcq" + "partner":"5lzt" }, { "sim":156.0, - "partner":"6zuo" + "partner":"6d9j" }, { "sim":156.0, - "partner":"5flx" + "partner":"6p4g" }, { "sim":156.0, - "partner":"6zv6" + "partner":"6w2s" }, { "sim":156.0, - "partner":"6zxd" + "partner":"4d61" }, { "sim":156.0, - "partner":"7o7y" + "partner":"6g5h" }, { "sim":156.0, - "partner":"5lzt" + "partner":"6zxe" }, { "sim":156.0, - "partner":"6p5i" + "partner":"7o81" }, { "sim":156.0, - "partner":"6d90" + "partner":"5lzw" }, { "sim":156.0, - "partner":"6hcj" + "partner":"5t2c" }, { "sim":156.0, - "partner":"6ip8" + "partner":"6g5i" }, { "sim":156.0, - "partner":"4d61" + "partner":"6y57" }, { "sim":156.0, - "partner":"5lzw" + "partner":"5aj0" }, { "sim":156.0, - "partner":"5t2c" + "partner":"6ybs" }, { "sim":156.0, - "partner":"6d9j" + "partner":"6z6m" }, { "sim":156.0, - "partner":"6p4g" + "partner":"6zxf" }, { "sim":156.0, - "partner":"6w2s" + "partner":"4d5l" }, { "sim":156.0, - "partner":"7o81" + "partner":"6p4h" }, { "sim":156.0, - "partner":"6g5h" + "partner":"5lzz" }, { "sim":156.0, - "partner":"6zxe" + "partner":"6g53" }, { "sim":156.0, - "partner":"5aj0" + "partner":"6y0g" }, { "sim":156.0, - "partner":"6g5i" + "partner":"7jqb" }, { "sim":156.0, - "partner":"4d5l" + "partner":"7mdz" }, { "sim":156.0, - "partner":"6y57" + "partner":"4v5z" }, { "sim":156.0, - "partner":"5lzz" + "partner":"5lzs" }, { "sim":156.0, - "partner":"6ybs" + "partner":"6zmw" }, { "sim":156.0, - "partner":"6z6m" + "partner":"7o80" }, { "sim":156.0, - "partner":"6zxf" + "partner":"6ip6" }, { "sim":156.0, - "partner":"6p4h" + "partner":"6p5n" }, { "sim":156.0, - "partner":"4v5z" + "partner":"6w2t" }, { "sim":156.0, - "partner":"5lzs" + "partner":"6zxg" }, { "sim":156.0, - "partner":"6g53" + "partner":"7jqc" }, { "sim":156.0, - "partner":"6y0g" + "partner":"5lzv" }, { "sim":156.0, - "partner":"7jqb" + "partner":"6zmi" }, { "sim":156.0, - "partner":"7mdz" + "partner":"4kzx" }, { "sim":156.0, - "partner":"7o80" + "partner":"7a09" + }, + { + "sim":156.0, + "partner":"7k5i" }, { "sim":156.0, @@ -420797,14 +422615,6 @@ "sim":154.0, "partner":"3fm0" }, - { - "sim":153.0, - "partner":"7a1g" - }, - { - "sim":153.0, - "partner":"7b7d" - }, { "sim":153.0, "partner":"6tnu" @@ -420815,11 +422625,11 @@ }, { "sim":153.0, - "partner":"6t7t" + "partner":"8uti" }, { "sim":153.0, - "partner":"8ut0" + "partner":"6t7t" }, { "sim":153.0, @@ -420831,51 +422641,43 @@ }, { "sim":153.0, - "partner":"8uti" - }, - { - "sim":153.0, - "partner":"6i7o" - }, - { - "sim":153.0, - "partner":"4v7h" + "partner":"8ut0" }, { "sim":153.0, - "partner":"6zvi" + "partner":"7a1g" }, { "sim":153.0, - "partner":"7nrd" + "partner":"7b7d" }, { "sim":153.0, - "partner":"1trj" + "partner":"4v7h" }, { "sim":153.0, - "partner":"4v92" + "partner":"6zvi" }, { "sim":153.0, - "partner":"6wdr" + "partner":"7nrd" }, { "sim":153.0, - "partner":"4u4q" + "partner":"6i7o" }, { "sim":153.0, - "partner":"5obm" + "partner":"1trj" }, { "sim":153.0, - "partner":"4u4r" + "partner":"4v92" }, { "sim":153.0, - "partner":"5tgm" + "partner":"6wdr" }, { "sim":153.0, @@ -420891,27 +422693,27 @@ }, { "sim":153.0, - "partner":"6woo" + "partner":"4uer" }, { "sim":153.0, - "partner":"4uer" + "partner":"6gqv" }, { "sim":153.0, - "partner":"4u4u" + "partner":"6q8y" }, { "sim":153.0, - "partner":"5mei" + "partner":"4u4u" }, { "sim":153.0, - "partner":"6gqv" + "partner":"5mei" }, { "sim":153.0, - "partner":"6q8y" + "partner":"5tgm" }, { "sim":153.0, @@ -420933,6 +422735,10 @@ "sim":153.0, "partner":"5ndv" }, + { + "sim":153.0, + "partner":"6gq1" + }, { "sim":153.0, "partner":"5ndw" @@ -420947,7 +422753,7 @@ }, { "sim":153.0, - "partner":"6gq1" + "partner":"6gqb" }, { "sim":153.0, @@ -420961,10 +422767,6 @@ "sim":153.0, "partner":"5dgv" }, - { - "sim":153.0, - "partner":"6gqb" - }, { "sim":153.0, "partner":"4u50" @@ -420975,15 +422777,15 @@ }, { "sim":153.0, - "partner":"5tbw" + "partner":"6s47" }, { "sim":153.0, - "partner":"4u51" + "partner":"5tbw" }, { "sim":153.0, - "partner":"6s47" + "partner":"4u51" }, { "sim":153.0, @@ -421035,79 +422837,83 @@ }, { "sim":153.0, - "partner":"3j6y" + "partner":"4u4q" }, { "sim":153.0, - "partner":"4v8y" + "partner":"5obm" }, { "sim":153.0, - "partner":"6zu9" + "partner":"4u4r" }, { "sim":153.0, - "partner":"5juo" + "partner":"6woo" }, { "sim":153.0, - "partner":"8t3f" + "partner":"6xiq" }, { "sim":153.0, - "partner":"6xiq" + "partner":"6zce" }, { "sim":153.0, - "partner":"6zce" + "partner":"8t3f" }, { "sim":153.0, "partner":"5mc6" }, + { + "sim":153.0, + "partner":"6z6j" + }, { "sim":153.0, "partner":"5jus" }, { "sim":153.0, - "partner":"6z6j" + "partner":"6t7i" }, { "sim":153.0, - "partner":"8p4v" + "partner":"6rbe" }, { "sim":153.0, - "partner":"8t2y" + "partner":"6t83" }, { "sim":153.0, - "partner":"6t7i" + "partner":"3j78" }, { "sim":153.0, - "partner":"8t3a" + "partner":"8t2y" }, { "sim":153.0, - "partner":"6rbe" + "partner":"5juu" }, { "sim":153.0, - "partner":"6t83" + "partner":"6snt" }, { "sim":153.0, - "partner":"8t30" + "partner":"8t3a" }, { "sim":153.0, - "partner":"3j78" + "partner":"8t30" }, { "sim":153.0, - "partner":"5juu" + "partner":"3j6x" }, { "sim":153.0, @@ -421115,39 +422921,39 @@ }, { "sim":153.0, - "partner":"3j6x" + "partner":"4v88" }, { "sim":153.0, - "partner":"6snt" + "partner":"6xir" }, { "sim":153.0, - "partner":"8t3e" + "partner":"8p4v" }, { "sim":153.0, - "partner":"4v88" + "partner":"4v7r" }, { "sim":153.0, - "partner":"4v7r" + "partner":"6hhq" }, { "sim":153.0, - "partner":"4v6i" + "partner":"8t3e" }, { "sim":153.0, - "partner":"5jup" + "partner":"4v6i" }, { "sim":153.0, - "partner":"6xir" + "partner":"5jup" }, { "sim":153.0, - "partner":"6hhq" + "partner":"6sv4" }, { "sim":153.0, @@ -421155,7 +422961,7 @@ }, { "sim":153.0, - "partner":"8p9a" + "partner":"6z6k" }, { "sim":153.0, @@ -421163,7 +422969,7 @@ }, { "sim":153.0, - "partner":"6sv4" + "partner":"3j77" }, { "sim":153.0, @@ -421171,15 +422977,15 @@ }, { "sim":153.0, - "partner":"6z6k" + "partner":"5jut" }, { "sim":153.0, - "partner":"3j77" + "partner":"6fai" }, { "sim":153.0, - "partner":"5jut" + "partner":"6zu9" }, { "sim":153.0, @@ -421187,12 +422993,24 @@ }, { "sim":153.0, - "partner":"6fai" + "partner":"8p9a" + }, + { + "sim":153.0, + "partner":"3j6y" + }, + { + "sim":153.0, + "partner":"4v8y" }, { "sim":153.0, "partner":"8t3b" }, + { + "sim":153.0, + "partner":"5juo" + }, { "sim":153.0, "partner":"8t3d" @@ -421231,63 +423049,63 @@ }, { "sim":150.0, - "partner":"7eg9" + "partner":"7egd" }, { "sim":150.0, - "partner":"7enc" + "partner":"7ega" }, { "sim":150.0, - "partner":"7egj" + "partner":"7egf" }, { "sim":150.0, - "partner":"7ena" + "partner":"7egi" }, { "sim":150.0, - "partner":"7egd" + "partner":"7egc" }, { "sim":150.0, - "partner":"7ega" + "partner":"7edx" }, { "sim":150.0, - "partner":"7egf" + "partner":"7eg7" }, { "sim":150.0, - "partner":"7egi" + "partner":"7egg" }, { "sim":150.0, - "partner":"7egc" + "partner":"7eg8" }, { "sim":150.0, - "partner":"7edx" + "partner":"7egb" }, { "sim":150.0, - "partner":"7eg7" + "partner":"7ege" }, { "sim":150.0, - "partner":"7egg" + "partner":"7eg9" }, { "sim":150.0, - "partner":"7eg8" + "partner":"7enc" }, { "sim":150.0, - "partner":"7egb" + "partner":"7egj" }, { "sim":150.0, - "partner":"7ege" + "partner":"7ena" }, { "sim":148.0, @@ -421295,11 +423113,11 @@ }, { "sim":147.0, - "partner":"6t9k" + "partner":"6t9i" }, { "sim":147.0, - "partner":"6t9i" + "partner":"6t9k" }, { "sim":147.0, @@ -421387,83 +423205,83 @@ }, { "sim":141.0, - "partner":"5ukk" + "partner":"8wgb" }, { "sim":141.0, - "partner":"7dfl" + "partner":"5ukl" }, { "sim":141.0, - "partner":"7k7z" + "partner":"6gdg" }, { "sim":141.0, - "partner":"7jjo" + "partner":"4mk0" }, { "sim":141.0, - "partner":"5ukl" + "partner":"5he0" }, { "sim":141.0, - "partner":"6gdg" + "partner":"5he1" }, { "sim":141.0, - "partner":"4mk0" + "partner":"7k7l" }, { "sim":141.0, - "partner":"5he0" + "partner":"6g79" }, { "sim":141.0, - "partner":"5he1" + "partner":"5he2" }, { "sim":141.0, - "partner":"7k7l" + "partner":"5he3" }, { "sim":141.0, - "partner":"5he2" + "partner":"7dfl" }, { "sim":141.0, - "partner":"6g79" + "partner":"5ukk" }, { "sim":141.0, - "partner":"8wgb" + "partner":"7k7z" }, { "sim":141.0, - "partner":"5he3" + "partner":"7jjo" }, { "sim":141.0, - "partner":"6wi9" + "partner":"7dhr" }, { "sim":141.0, - "partner":"7o7f" + "partner":"8k4s" }, { "sim":141.0, - "partner":"4kfm" + "partner":"5kdo" }, { "sim":141.0, - "partner":"6x18" + "partner":"6pcv" }, { "sim":141.0, - "partner":"5kdo" + "partner":"6vms" }, { "sim":141.0, - "partner":"7dhr" + "partner":"6x19" }, { "sim":141.0, @@ -421471,19 +423289,19 @@ }, { "sim":141.0, - "partner":"6pcv" + "partner":"8p15" }, { "sim":141.0, - "partner":"6vms" + "partner":"6niy" }, { "sim":141.0, - "partner":"6x19" + "partner":"7f1q" }, { "sim":141.0, - "partner":"6niy" + "partner":"8vve" }, { "sim":141.0, @@ -421491,15 +423309,19 @@ }, { "sim":141.0, - "partner":"7f1q" + "partner":"7lci" }, { "sim":141.0, - "partner":"7lci" + "partner":"7f1r" }, { "sim":141.0, - "partner":"8k4s" + "partner":"8vvf" + }, + { + "sim":141.0, + "partner":"6c2y" }, { "sim":141.0, @@ -421507,27 +423329,27 @@ }, { "sim":141.0, - "partner":"1gg2" + "partner":"6kpf" }, { "sim":141.0, - "partner":"3pvu" + "partner":"8zjg" }, { "sim":141.0, - "partner":"4pnk" + "partner":"3pvu" }, { "sim":141.0, - "partner":"6c2y" + "partner":"4pnk" }, { "sim":141.0, - "partner":"7f1r" + "partner":"7bz2" }, { "sim":141.0, - "partner":"8p12" + "partner":"7f1s" }, { "sim":141.0, @@ -421539,7 +423361,7 @@ }, { "sim":141.0, - "partner":"6kpf" + "partner":"7dhi" }, { "sim":141.0, @@ -421547,27 +423369,27 @@ }, { "sim":141.0, - "partner":"7bz2" + "partner":"6whc" }, { "sim":141.0, - "partner":"1gp2" + "partner":"8vvg" }, { "sim":141.0, - "partner":"5wg3" + "partner":"1gg2" }, { "sim":141.0, - "partner":"6whc" + "partner":"5wg3" }, { "sim":141.0, - "partner":"7dhi" + "partner":"7ki1" }, { "sim":141.0, - "partner":"7f1s" + "partner":"7mbx" }, { "sim":141.0, @@ -421575,11 +423397,7 @@ }, { "sim":141.0, - "partner":"7ki1" - }, - { - "sim":141.0, - "partner":"7mbx" + "partner":"6wzg" }, { "sim":141.0, @@ -421591,7 +423409,7 @@ }, { "sim":141.0, - "partner":"8p13" + "partner":"1gp2" }, { "sim":141.0, @@ -421601,10 +423419,6 @@ "sim":141.0, "partner":"5wg4" }, - { - "sim":141.0, - "partner":"6wzg" - }, { "sim":141.0, "partner":"1xhm" @@ -421615,11 +423429,11 @@ }, { "sim":141.0, - "partner":"3krw" + "partner":"6qno" }, { "sim":141.0, - "partner":"5wg5" + "partner":"6rmv" }, { "sim":141.0, @@ -421631,15 +423445,19 @@ }, { "sim":141.0, - "partner":"6qno" + "partner":"8p12" }, { "sim":141.0, - "partner":"6rmv" + "partner":"8xqe" }, { "sim":141.0, - "partner":"3krx" + "partner":"3krw" + }, + { + "sim":141.0, + "partner":"5wg5" }, { "sim":141.0, @@ -421647,7 +423465,11 @@ }, { "sim":141.0, - "partner":"8p15" + "partner":"8z7j" + }, + { + "sim":141.0, + "partner":"3krx" }, { "sim":141.0, @@ -421655,7 +423477,27 @@ }, { "sim":141.0, - "partner":"6m1h" + "partner":"6wi9" + }, + { + "sim":141.0, + "partner":"6x18" + }, + { + "sim":141.0, + "partner":"7o7f" + }, + { + "sim":141.0, + "partner":"8p13" + }, + { + "sim":141.0, + "partner":"8xqf" + }, + { + "sim":141.0, + "partner":"4kfm" }, { "sim":141.0, @@ -421663,11 +423505,11 @@ }, { "sim":141.0, - "partner":"5tdh" + "partner":"6m1h" }, { "sim":141.0, - "partner":"6xbk" + "partner":"5tdh" }, { "sim":141.0, @@ -421691,11 +423533,11 @@ }, { "sim":141.0, - "partner":"6dde" + "partner":"7db6" }, { "sim":141.0, - "partner":"7db6" + "partner":"6dde" }, { "sim":141.0, @@ -421707,28 +423549,16 @@ }, { "sim":141.0, - "partner":"6nbi" - }, - { - "sim":141.0, - "partner":"6oij" - }, - { - "sim":141.0, - "partner":"7duq" + "partner":"6xbk" }, { "sim":141.0, - "partner":"7e32" + "partner":"7dur" }, { "sim":141.0, "partner":"6oik" }, - { - "sim":141.0, - "partner":"7dur" - }, { "sim":141.0, "partner":"7e33" @@ -421741,6 +423571,10 @@ "sim":141.0, "partner":"7evm" }, + { + "sim":141.0, + "partner":"7e2x" + }, { "sim":141.0, "partner":"7jhj" @@ -421755,15 +423589,15 @@ }, { "sim":141.0, - "partner":"7e2x" + "partner":"7cmu" }, { "sim":141.0, - "partner":"6pb0" + "partner":"7e2y" }, { "sim":141.0, - "partner":"7cmu" + "partner":"6pb0" }, { "sim":141.0, @@ -421771,11 +423605,11 @@ }, { "sim":141.0, - "partner":"7e2y" + "partner":"7exd" }, { "sim":141.0, - "partner":"7exd" + "partner":"7e14" }, { "sim":141.0, @@ -421783,7 +423617,7 @@ }, { "sim":141.0, - "partner":"7e14" + "partner":"7e2z" }, { "sim":141.0, @@ -421791,15 +423625,27 @@ }, { "sim":141.0, - "partner":"7e2z" + "partner":"6pb1" }, { "sim":141.0, - "partner":"6pb1" + "partner":"6crk" }, { "sim":141.0, - "partner":"6crk" + "partner":"6nbi" + }, + { + "sim":141.0, + "partner":"7duq" + }, + { + "sim":141.0, + "partner":"7e32" + }, + { + "sim":141.0, + "partner":"6oij" }, { "sim":141.0, @@ -421819,11 +423665,11 @@ }, { "sim":141.0, - "partner":"7jvr" + "partner":"7ckz" }, { "sim":141.0, - "partner":"7ckz" + "partner":"7jvr" }, { "sim":141.0, @@ -421839,47 +423685,43 @@ }, { "sim":141.0, - "partner":"6d9h" - }, - { - "sim":141.0, - "partner":"6p9x" + "partner":"6vcb" }, { "sim":141.0, - "partner":"6uva" + "partner":"7joz" }, { "sim":141.0, - "partner":"6k42" + "partner":"6p9y" }, { "sim":141.0, - "partner":"6xox" + "partner":"8xx3" }, { "sim":141.0, - "partner":"6vcb" + "partner":"5ukm" }, { "sim":141.0, - "partner":"7joz" + "partner":"6e3y" }, { "sim":141.0, - "partner":"5ukm" + "partner":"7ld3" }, { "sim":141.0, - "partner":"6p9y" + "partner":"6m8s" }, { "sim":141.0, - "partner":"7ld3" + "partner":"6ni3" }, { "sim":141.0, - "partner":"6e3y" + "partner":"7c2e" }, { "sim":141.0, @@ -421887,15 +423729,15 @@ }, { "sim":141.0, - "partner":"6m8s" + "partner":"8xx7" }, { "sim":141.0, - "partner":"6ni3" + "partner":"8xwv" }, { "sim":141.0, - "partner":"7c2e" + "partner":"8xxh" }, { "sim":141.0, @@ -421909,13 +423751,21 @@ "sim":141.0, "partner":"6orv" }, + { + "sim":141.0, + "partner":"8tyw" + }, { "sim":141.0, "partner":"6uus" }, { "sim":141.0, - "partner":"8tyw" + "partner":"8jzp" + }, + { + "sim":141.0, + "partner":"8xxx" }, { "sim":141.0, @@ -421923,7 +423773,31 @@ }, { "sim":141.0, - "partner":"7e9h" + "partner":"8xxr" + }, + { + "sim":141.0, + "partner":"6d9h" + }, + { + "sim":141.0, + "partner":"6p9x" + }, + { + "sim":141.0, + "partner":"6uva" + }, + { + "sim":141.0, + "partner":"8xx6" + }, + { + "sim":141.0, + "partner":"6k42" + }, + { + "sim":141.0, + "partner":"6xox" }, { "sim":141.0, @@ -421963,15 +423837,15 @@ }, { "sim":141.0, - "partner":"3sn6" + "partner":"7e9g" }, { "sim":141.0, - "partner":"7e9g" + "partner":"7ezm" }, { "sim":141.0, - "partner":"7ezm" + "partner":"3sn6" }, { "sim":141.0, @@ -421981,6 +423855,10 @@ "sim":141.0, "partner":"6ot0" }, + { + "sim":141.0, + "partner":"7e9h" + }, { "sim":141.0, "partner":"7ljc" @@ -422011,15 +423889,15 @@ }, { "sim":141.0, - "partner":"7ckx" + "partner":"8x3l" }, { "sim":141.0, - "partner":"7crh" + "partner":"7ckx" }, { "sim":141.0, - "partner":"8x3l" + "partner":"7crh" }, { "sim":141.0, @@ -422029,21 +423907,17 @@ "sim":141.0, "partner":"7aue" }, - { - "sim":141.0, - "partner":"7cx2" - }, { "sim":141.0, "partner":"6wpw" }, { "sim":141.0, - "partner":"8rql" + "partner":"7cx3" }, { "sim":141.0, - "partner":"7cx3" + "partner":"8rql" }, { "sim":141.0, @@ -422067,7 +423941,7 @@ }, { "sim":141.0, - "partner":"7l0r" + "partner":"7cx2" }, { "sim":141.0, @@ -422083,31 +423957,31 @@ }, { "sim":141.0, - "partner":"7f4h" + "partner":"7l0r" }, { "sim":141.0, - "partner":"7f9y" + "partner":"8zfz" }, { "sim":141.0, - "partner":"7f16" + "partner":"7f4d" }, { "sim":141.0, - "partner":"7dw9" + "partner":"8vhf" }, { "sim":141.0, - "partner":"7f4d" + "partner":"7f9z" }, { "sim":141.0, - "partner":"7f9z" + "partner":"7f4i" }, { "sim":141.0, - "partner":"7f4i" + "partner":"7f4f" }, { "sim":141.0, @@ -422115,23 +423989,39 @@ }, { "sim":141.0, - "partner":"7f4f" + "partner":"7bb6" }, { "sim":141.0, - "partner":"7bb6" + "partner":"7bb7" }, { "sim":141.0, - "partner":"8vhf" + "partner":"7dty" }, { "sim":141.0, - "partner":"7bb7" + "partner":"7f4h" }, { "sim":141.0, - "partner":"7dty" + "partner":"7f9y" + }, + { + "sim":141.0, + "partner":"7f16" + }, + { + "sim":141.0, + "partner":"7dw9" + }, + { + "sim":141.0, + "partner":"8wwi" + }, + { + "sim":141.0, + "partner":"8wwj" }, { "sim":141.0, @@ -422155,15 +424045,11 @@ }, { "sim":141.0, - "partner":"8wwi" - }, - { - "sim":141.0, - "partner":"8wwj" + "partner":"6vn7" }, { "sim":141.0, - "partner":"6vn7" + "partner":"8jsr" }, { "sim":141.0, @@ -422175,11 +424061,11 @@ }, { "sim":140.0, - "partner":"1got" + "partner":"2trc" }, { "sim":140.0, - "partner":"2trc" + "partner":"1got" }, { "sim":140.0, @@ -422255,35 +424141,35 @@ }, { "sim":135.0, - "partner":"3jam" + "partner":"6fyx" }, { "sim":135.0, - "partner":"3jap" + "partner":"6uz7" }, { "sim":135.0, - "partner":"6fyy" + "partner":"3j80" }, { "sim":135.0, - "partner":"3j80" + "partner":"3j81" }, { "sim":135.0, - "partner":"6fyx" + "partner":"8s8k" }, { "sim":135.0, - "partner":"6uz7" + "partner":"3jam" }, { "sim":135.0, - "partner":"3j81" + "partner":"3jap" }, { "sim":135.0, - "partner":"8s8k" + "partner":"6fyy" }, { "sim":134.0, @@ -422297,10 +424183,6 @@ "sim":133.0, "partner":"6wnx" }, - { - "sim":133.0, - "partner":"6m90" - }, { "sim":133.0, "partner":"6m91" @@ -422317,6 +424199,10 @@ "sim":133.0, "partner":"6m94" }, + { + "sim":133.0, + "partner":"6m90" + }, { "sim":133.0, "partner":"1p22" @@ -422347,11 +424233,11 @@ }, { "sim":133.0, - "partner":"5oql" + "partner":"6rxz" }, { "sim":133.0, - "partner":"6rxz" + "partner":"5oql" }, { "sim":132.0, @@ -422435,11 +424321,11 @@ }, { "sim":129.0, - "partner":"4v5o" + "partner":"4bts" }, { "sim":129.0, - "partner":"4bts" + "partner":"4v5o" }, { "sim":126.0, @@ -422453,10 +424339,6 @@ "sim":126.0, "partner":"7dco" }, - { - "sim":126.0, - "partner":"7b9v" - }, { "sim":126.0, "partner":"6bk8" @@ -422467,11 +424349,11 @@ }, { "sim":126.0, - "partner":"5wsg" + "partner":"6j6q" }, { "sim":126.0, - "partner":"6j6q" + "partner":"5wsg" }, { "sim":126.0, @@ -422485,6 +424367,10 @@ "sim":126.0, "partner":"5y88" }, + { + "sim":126.0, + "partner":"6j6g" + }, { "sim":126.0, "partner":"5gm6" @@ -422495,7 +424381,7 @@ }, { "sim":126.0, - "partner":"6j6g" + "partner":"6j6n" }, { "sim":126.0, @@ -422503,23 +424389,23 @@ }, { "sim":126.0, - "partner":"6j6n" + "partner":"5lqw" }, { "sim":126.0, - "partner":"5lqw" + "partner":"6j6h" }, { "sim":126.0, - "partner":"5mps" + "partner":"7b9v" }, { "sim":126.0, - "partner":"5ylz" + "partner":"5mps" }, { "sim":126.0, - "partner":"6j6h" + "partner":"5ylz" }, { "sim":126.0, @@ -422533,18 +424419,6 @@ "sim":125.0, "partner":"3mkq" }, - { - "sim":125.0, - "partner":"6ke6" - }, - { - "sim":125.0, - "partner":"6lqq" - }, - { - "sim":125.0, - "partner":"7ajt" - }, { "sim":125.0, "partner":"6lqr" @@ -422605,6 +424479,18 @@ "sim":125.0, "partner":"6lqp" }, + { + "sim":125.0, + "partner":"6ke6" + }, + { + "sim":125.0, + "partner":"6lqq" + }, + { + "sim":125.0, + "partner":"7ajt" + }, { "sim":124.0, "partner":"4j86" @@ -422755,35 +424641,35 @@ }, { "sim":104.0, - "partner":"5khr" + "partner":"6q6h" }, { "sim":104.0, - "partner":"6f0x" + "partner":"6q6g" }, { "sim":104.0, - "partner":"6q6h" + "partner":"5khu" }, { "sim":104.0, - "partner":"5khu" + "partner":"5g04" }, { "sim":104.0, - "partner":"6q6g" + "partner":"6f0x" }, { "sim":104.0, - "partner":"5g04" + "partner":"5khr" }, { "sim":103.0, - "partner":"1pev" + "partner":"1nr0" }, { "sim":103.0, - "partner":"1nr0" + "partner":"1pev" }, { "sim":102.0, @@ -422807,15 +424693,15 @@ }, { "sim":101.0, - "partner":"7ay2" + "partner":"5k1c" }, { "sim":101.0, - "partner":"5k1c" + "partner":"7ay0" }, { "sim":101.0, - "partner":"7ay0" + "partner":"7ay2" }, { "sim":101.0, @@ -422903,43 +424789,43 @@ }, { "sim":92.0, - "partner":"3mzk" + "partner":"3mzl" }, { "sim":92.0, - "partner":"6zg5" + "partner":"6zg6" }, { "sim":92.0, - "partner":"4xmm" + "partner":"3iko" }, { "sim":92.0, - "partner":"3mzl" + "partner":"4xmn" }, { "sim":92.0, - "partner":"3iko" + "partner":"2pm6" }, { "sim":92.0, - "partner":"6zg6" + "partner":"6zl0" }, { "sim":92.0, - "partner":"4xmn" + "partner":"4bzk" }, { "sim":92.0, - "partner":"2pm6" + "partner":"6zg5" }, { "sim":92.0, - "partner":"6zl0" + "partner":"3mzk" }, { "sim":92.0, - "partner":"4bzk" + "partner":"4xmm" }, { "sim":92.0, @@ -422961,25 +424847,17 @@ "sim":90.0, "partner":"6chg" }, - { - "sim":90.0, - "partner":"5flc" - }, - { - "sim":90.0, - "partner":"6sb0" - }, { "sim":90.0, "partner":"4jsv" }, { "sim":90.0, - "partner":"5h64" + "partner":"7pea" }, { "sim":90.0, - "partner":"7pea" + "partner":"5h64" }, { "sim":90.0, @@ -423027,11 +424905,11 @@ }, { "sim":90.0, - "partner":"4jt6" + "partner":"6zwo" }, { "sim":90.0, - "partner":"6zwo" + "partner":"4jt6" }, { "sim":90.0, @@ -423051,7 +424929,11 @@ }, { "sim":90.0, - "partner":"6uh5" + "partner":"6sb0" + }, + { + "sim":90.0, + "partner":"5flc" }, { "sim":90.0, @@ -423059,12 +424941,16 @@ }, { "sim":90.0, - "partner":"5wbu" + "partner":"6uh5" }, { "sim":90.0, "partner":"5wby" }, + { + "sim":90.0, + "partner":"5wbu" + }, { "sim":87.0, "partner":"5wjc" @@ -423115,27 +425001,23 @@ }, { "sim":84.0, - "partner":"2xu7" - }, - { - "sim":84.0, - "partner":"7ktp" + "partner":"6g16" }, { "sim":84.0, - "partner":"6g16" + "partner":"7aoa" }, { "sim":84.0, - "partner":"5fxy" + "partner":"8vml" }, { "sim":84.0, - "partner":"7aoa" + "partner":"6c24" }, { "sim":84.0, - "partner":"6c24" + "partner":"5fxy" }, { "sim":84.0, @@ -423149,18 +425031,26 @@ "sim":84.0, "partner":"4pby" }, + { + "sim":84.0, + "partner":"8vmi" + }, { "sim":84.0, "partner":"4pbz" }, { "sim":84.0, - "partner":"4pc0" + "partner":"8vnv" }, { "sim":84.0, "partner":"7ksr" }, + { + "sim":84.0, + "partner":"4pc0" + }, { "sim":84.0, "partner":"6c23" @@ -423169,13 +425059,25 @@ "sim":84.0, "partner":"7kso" }, + { + "sim":84.0, + "partner":"6zrd" + }, + { + "sim":84.0, + "partner":"8vnz" + }, { "sim":84.0, "partner":"3gfc" }, { "sim":84.0, - "partner":"6zrd" + "partner":"2xu7" + }, + { + "sim":84.0, + "partner":"7ktp" }, { "sim":84.0, @@ -423193,10 +425095,6 @@ "sim":84.0, "partner":"5vtb" }, - { - "sim":84.0, - "partner":"6nq3" - }, { "sim":84.0, "partner":"5wai" @@ -423207,7 +425105,7 @@ }, { "sim":84.0, - "partner":"5xwr" + "partner":"6nq3" }, { "sim":84.0, @@ -423215,16 +425113,20 @@ }, { "sim":84.0, - "partner":"8tx8" + "partner":"5xwr" }, { "sim":84.0, - "partner":"5xxq" + "partner":"8tx8" }, { "sim":84.0, "partner":"5y1u" }, + { + "sim":84.0, + "partner":"5xxq" + }, { "sim":81.0, "partner":"6b3x" @@ -423259,11 +425161,11 @@ }, { "sim":75.0, - "partner":"5vh9" + "partner":"5vlj" }, { "sim":75.0, - "partner":"5vlj" + "partner":"5vh9" }, { "sim":74.0, @@ -423279,15 +425181,15 @@ }, { "sim":73.0, - "partner":"3f3g" + "partner":"3f3p" }, { "sim":73.0, - "partner":"3f3p" + "partner":"3f3f" }, { "sim":73.0, - "partner":"3f3f" + "partner":"3f3g" }, { "sim":73.0, @@ -423375,11 +425277,11 @@ }, { "sim":69.0, - "partner":"5m2n" + "partner":"6qk7" }, { "sim":69.0, - "partner":"6qk7" + "partner":"5m2n" }, { "sim":69.0, @@ -423453,14 +425355,6 @@ "sim":67.0, "partner":"6elz" }, - { - "sim":66.0, - "partner":"5m5g" - }, - { - "sim":66.0, - "partner":"5wfd" - }, { "sim":66.0, "partner":"5bjs" @@ -423493,41 +425387,49 @@ "sim":66.0, "partner":"5wfc" }, + { + "sim":66.0, + "partner":"5m5g" + }, + { + "sim":66.0, + "partner":"5wfd" + }, { "sim":66.0, "partner":"4ci8" }, { "sim":63.0, - "partner":"6qtv" + "partner":"6qto" }, { "sim":63.0, - "partner":"6qtw" + "partner":"6qtq" }, { "sim":63.0, - "partner":"6qtx" + "partner":"6qtr" }, { "sim":63.0, - "partner":"6qto" + "partner":"6qtt" }, { "sim":63.0, - "partner":"6qtq" + "partner":"6qtu" }, { "sim":63.0, - "partner":"6qtr" + "partner":"6qtv" }, { "sim":63.0, - "partner":"6qtt" + "partner":"6qtw" }, { "sim":63.0, - "partner":"6qtu" + "partner":"6qtx" }, { "sim":63.0, @@ -423571,19 +425473,19 @@ }, { "sim":57.0, - "partner":"2aq5" + "partner":"2b4e" }, { "sim":57.0, - "partner":"2b4e" + "partner":"2aq5" }, { "sim":56.0, - "partner":"7m05" + "partner":"6v0n" }, { "sim":56.0, - "partner":"6v0n" + "partner":"7m05" }, { "sim":56.0, @@ -423611,63 +425513,63 @@ }, { "sim":56.0, - "partner":"4x63" + "partner":"4x60" }, { "sim":56.0, - "partner":"7kid" + "partner":"4x61" }, { "sim":56.0, - "partner":"6uxx" + "partner":"5c9z" }, { "sim":56.0, - "partner":"6uxy" + "partner":"5emj" }, { "sim":56.0, - "partner":"4x60" + "partner":"6k1s" }, { "sim":56.0, - "partner":"4x61" + "partner":"7l1g" }, { "sim":56.0, - "partner":"5c9z" + "partner":"5emk" }, { "sim":56.0, - "partner":"5emj" + "partner":"5eml" }, { "sim":56.0, - "partner":"5emk" + "partner":"7kib" }, { "sim":56.0, - "partner":"6k1s" + "partner":"5emm" }, { "sim":56.0, - "partner":"7l1g" + "partner":"7kic" }, { "sim":56.0, - "partner":"5eml" + "partner":"6uxx" }, { "sim":56.0, - "partner":"7kib" + "partner":"7kid" }, { "sim":56.0, - "partner":"5emm" + "partner":"4x63" }, { "sim":56.0, - "partner":"7kic" + "partner":"6uxy" }, { "sim":56.0, @@ -423796,99 +425698,99 @@ ], "subtitle":"A de novo designed nonameric coiled coil, cc-type2-(gglaid)4", "tags":[ + "coiled coil", "nonamer", "de novo protein", - "coiled coil", - "alpha-helical barrel", - "synthetic" + "synthetic", + "alpha-helical barrel" ], "keywords":[ - "amphipathic", - "oligomers", - "z", - "pentameric", - "must", - "discriminate", - "pattern", - "controllably", - "accessed", + "made", + "repeats", "allow", - "dimeric", - "smaller", - "crystal", - "target", + "hydrophobic", "show", - "sequences", + "glycine", "closer", - "however", - "alternative", - "expanding", - "contacts", - "direct", - "forces", - "interfaces", - "progressively", - "larger", - "unique", - "de", - "h", - "produce", + "pattern", + "side", + "accessed", + "short", + "residue", + "pentameric", "linear", - "nonetheless", - "point", - "hpphppp", + "helical", + "tetrameric", + "novo", + "controllably", + "hpphhph", + "crystal", + "predictably", + "weak", + "helices", + "chains", + "water", + "alternative", + "however", + "bundles", "decreasing", - "resulting", - "short", - "made", - "assemble", + "p", + "nonameric", + "residues", + "helix", "gives", - "structures", - "assembly", + "polar", + "progressively", + "contacts", + "sites", "size", - "alanine", - "predictably", - "considerable", - "directly", - "serine", - "assemblies", - "bundles", - "four", - "glycine", - "challenging", + "hpphppp", + "larger", + "nominally", + "threonine", "stabilize", + "four", + "serine", + "direct", "design", - "encode", - "avoid", - "helical", - "weak", + "challenging", + "must", + "discriminate", + "produce", + "assembly", + "alanine", + "point", + "forces", + "varying", + "rationalize", "states", - "hydrophobic", - "progress", "sequence", - "repeats", - "rationalize", - "threonine", - "tetrameric", - "sites", - "chains", + "peptides", + "encode", + "expanding", + "nonetheless", + "unique", + "assemblies", + "amphipathic", + "directly", + "h", + "z", + "sequences", "one", - "helices", - "barrels", - "novo", - "nonameric", + "interfaces", + "structures", + "de", "rational", - "peptides", - "nominally", - "residues", - "polar", - "hpphhph", - "residue", - "helix", - "water", - "varying", - "side", - "p" + "progress", + "oligomers", + "resulting", + "target", + "considerable", + "smaller", + "assemble", + "avoid", + "barrels", + "dimeric" ], "release_date":"2021-04-21", "publication":"\"Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states\", Chem Sci, 12, 6923-6928", @@ -423933,121 +425835,105 @@ "sim":1.0, "partner":"7baw" }, - { - "sim":1.0, - "partner":"8a09" - }, { "sim":0.9973999858, "partner":"7bat" }, - { - "sim":0.9959999919, - "partner":"8b15" - }, { "sim":1.0, - "partner":"8b16" + "partner":"8a09" }, { "sim":1.0, "partner":"4pn9" }, - { - "sim":1.0, - "partner":"4pna" - }, { "sim":0.9984999895, "partner":"6eiz" }, { "sim":1.0, - "partner":"5ez8" + "partner":"8b16" }, { "sim":1.0, - "partner":"7bas" + "partner":"4pna" }, { - "sim":1.0, - "partner":"7nfj" + "sim":0.9959999919, + "partner":"8b15" }, { "sim":1.0, - "partner":"7nfk" + "partner":"6xy1" }, { "sim":1.0, - "partner":"7bav" + "partner":"7bas" }, { "sim":1.0, - "partner":"6eik" + "partner":"7bav" }, { "sim":1.0, - "partner":"6xy1" + "partner":"5ez8" }, { "sim":1.0, - "partner":"7nfl" + "partner":"7nff" }, { "sim":1.0, - "partner":"5ez9" + "partner":"7nfi" }, { "sim":1.0, - "partner":"7nfn" + "partner":"7nfj" }, { "sim":1.0, - "partner":"7nfo" + "partner":"7nfl" }, { "sim":1.0, - "partner":"5ezc" + "partner":"7nfm" }, { "sim":1.0, - "partner":"6g6f" + "partner":"7nfk" }, { "sim":1.0, - "partner":"7bau" + "partner":"7nfg" }, { "sim":1.0, - "partner":"7nfh" - }, - { - "sim":0.9930999875, - "partner":"6g6b" + "partner":"7nfo" }, { - "sim":0.9592000246, - "partner":"5eze" + "sim":1.0, + "partner":"5ez9" }, { - "sim":0.9954000115, - "partner":"6g6a" + "sim":1.0, + "partner":"6eik" }, { "sim":1.0, - "partner":"7nff" + "partner":"5eza" }, { "sim":1.0, - "partner":"7nfi" + "partner":"6yb2" }, { "sim":1.0, - "partner":"7nfm" + "partner":"7nfn" }, { "sim":1.0, - "partner":"6g6d" + "partner":"5ezc" }, { "sim":1.0, @@ -424055,23 +425941,19 @@ }, { "sim":1.0, - "partner":"7nfg" - }, - { - "sim":0.9769999981, - "partner":"6yb0" + "partner":"6g6d" }, { "sim":1.0, - "partner":"6yb2" + "partner":"6g6f" }, { - "sim":0.9732000232, - "partner":"6yaz" + "sim":1.0, + "partner":"7nfh" }, { "sim":1.0, - "partner":"5eza" + "partner":"7nfp" }, { "sim":1.0, @@ -424082,12 +425964,8 @@ "partner":"6xy0" }, { - "sim":1.0, - "partner":"7nfp" - }, - { - "sim":0.9918000102, - "partner":"7bo9" + "sim":0.9732000232, + "partner":"6yaz" }, { "sim":1.0, @@ -424102,24 +425980,28 @@ "partner":"6g67" }, { - "sim":1.0, - "partner":"6g69" + "sim":0.9769999981, + "partner":"6yb0" }, { - "sim":0.9925000072, - "partner":"6zt1" + "sim":0.9930999875, + "partner":"6g6b" }, { "sim":1.0, - "partner":"6g66" + "partner":"7bau" + }, + { + "sim":0.9954000115, + "partner":"6g6a" }, { "sim":1.0, - "partner":"7bo8" + "partner":"6g66" }, { "sim":1.0, - "partner":"4dzk" + "partner":"6g69" }, { "sim":1.0, @@ -424132,6 +426014,26 @@ { "sim":0.997699976, "partner":"6i1j" + }, + { + "sim":0.9592000246, + "partner":"5eze" + }, + { + "sim":0.9918000102, + "partner":"7bo9" + }, + { + "sim":0.9925000072, + "partner":"6zt1" + }, + { + "sim":1.0, + "partner":"7bo8" + }, + { + "sim":1.0, + "partner":"4dzk" } ], "struct_thr_sim_natural":[ @@ -424145,7 +426047,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"7baw" + "partner":"7a1t" }, "struct_max_sim_natural":{ "sim":0.855799973, @@ -424209,102 +426111,102 @@ ], "subtitle":"A hexameric de novo coiled-coil assembly: cc-type2-(vayd)4-y3f-w19(brphe)-y24f", "tags":[ + "coiled coil", "synthetic peptide", "de novo protein", - "coiled coil", - "tyrosine-tyrosine interactions", - "homomeric assembly" + "homomeric assembly", + "tyrosine-tyrosine interactions" ], "keywords":[ - "containing", - "tetramer", - "amphipathic", - "many", + "allow", + "hydrophobic", + "structural", "background", - "use", + "core", + "lead", + "extended", "acid", - "including", - "designed", - "consequences", - "allow", - "requires", - "current", - "generally", - "sequences", + "tyrosine", + "new", + "make", + "folding", + "drive", + "protein", + "network", + "probes", + "binding", + "cc", "\u03b1", - "structure", "networks", - "resolve", - "pack", - "rich", - "however", - "aromatic", - "interfaces", + "novo", "general", - "coiled", - "network", - "cc", - "de", - "advanced", + "catalytic", + "helices", + "rules", + "using", + "complex", + "knowledge", + "antiparallel", + "however", "aliphatic", - "interface", - "targeted", - "drive", - "lead", - "structures", + "accessible", + "residues", + "specific", + "polar", + "ccs", + "subset", "buried", + "useful", + "generally", + "use", + "entirely", "center", + "interface", "coils", - "assembly", - "form", - "rules", - "solvent", - "another", - "amino", "sufficiently", - "assemblies", - "extended", - "ccs", - "catalytic", - "namely", - "would", - "subset", - "useful", - "specific", + "including", + "surface", + "tetramer", "design", - "tyrosine", - "core", + "another", + "current", + "assembly", + "rich", + "fold", + "consequences", + "explore", + "resolve", + "namely", + "amino", + "understood", + "requires", "predominantly", - "using", - "hydrophobic", - "surface", + "assemblies", + "amphipathic", + "folds", + "designed", + "form", "introducing", - "known", - "structural", - "make", + "pack", + "sequences", + "aromatic", + "many", + "interfaces", "one", - "entirely", - "helices", - "accessible", - "novo", + "targeted", + "structures", + "de", "rational", - "fold", - "residues", - "understood", - "folds", - "antiparallel", - "polar", - "explore", + "structure", + "understanding", + "known", + "would", "examples", - "protein", - "complex", - "knowledge", + "coiled", + "solvent", "contribution", - "understanding", - "folding", - "binding", - "probes", - "new" + "containing", + "advanced" ], "release_date":"2021-05-19", "publication":"\"How Coiled-Coil Assemblies Accommodate Multiple Aromatic Residues\", Biomacromolecules, 22, 2010-2019", @@ -424556,102 +426458,102 @@ ], "subtitle":"A hexameric de novo coiled-coil assembly: cc-type2-(vayd)4-y3f-w19(brphe)", "tags":[ + "coiled coil", "synthetic peptide", "de novo protein", - "coiled coil", - "tyrosine-tyrosine interactions", - "homomeric assembly" + "homomeric assembly", + "tyrosine-tyrosine interactions" ], "keywords":[ - "containing", - "tetramer", - "amphipathic", - "many", + "allow", + "hydrophobic", + "structural", "background", - "use", + "core", + "lead", + "extended", "acid", - "including", - "designed", - "consequences", - "allow", - "requires", - "current", - "generally", - "sequences", + "tyrosine", + "new", + "make", + "folding", + "drive", + "protein", + "network", + "probes", + "binding", + "cc", "\u03b1", - "structure", "networks", - "resolve", - "pack", - "rich", - "however", - "aromatic", - "interfaces", + "novo", "general", - "coiled", - "network", - "cc", - "de", - "advanced", + "catalytic", + "helices", + "rules", + "using", + "complex", + "knowledge", + "antiparallel", + "however", "aliphatic", - "interface", - "targeted", - "drive", - "lead", - "structures", + "accessible", + "residues", + "specific", + "polar", + "ccs", + "subset", "buried", + "useful", + "generally", + "use", + "entirely", "center", + "interface", "coils", - "assembly", - "form", - "rules", - "solvent", - "another", - "amino", "sufficiently", - "assemblies", - "extended", - "ccs", - "catalytic", - "namely", - "would", - "subset", - "useful", - "specific", + "including", + "surface", + "tetramer", "design", - "tyrosine", - "core", + "another", + "current", + "assembly", + "rich", + "fold", + "consequences", + "explore", + "resolve", + "namely", + "amino", + "understood", + "requires", "predominantly", - "using", - "hydrophobic", - "surface", + "assemblies", + "amphipathic", + "folds", + "designed", + "form", "introducing", - "known", - "structural", - "make", + "pack", + "sequences", + "aromatic", + "many", + "interfaces", "one", - "entirely", - "helices", - "accessible", - "novo", + "targeted", + "structures", + "de", "rational", - "fold", - "residues", - "understood", - "folds", - "antiparallel", - "polar", - "explore", + "structure", + "understanding", + "known", + "would", "examples", - "protein", - "complex", - "knowledge", + "coiled", + "solvent", "contribution", - "understanding", - "folding", - "binding", - "probes", - "new" + "containing", + "advanced" ], "release_date":"2021-05-19", "publication":"\"How Coiled-Coil Assemblies Accommodate Multiple Aromatic Residues\", Biomacromolecules, 22, 2010-2019", @@ -424696,61 +426598,29 @@ "sim":1.0, "partner":"6g6f" }, - { - "sim":1.0, - "partner":"6g69" - }, - { - "sim":1.0, - "partner":"6g68" - }, { "sim":0.9986000061, "partner":"6g6b" }, - { - "sim":1.0, - "partner":"6g6c" - }, { "sim":0.9952999949, "partner":"7bau" }, - { - "sim":0.9927999973, - "partner":"6g6a" - }, - { - "sim":0.9983000159, - "partner":"6g6d" - }, { "sim":0.9921000004, "partner":"7bat" }, - { - "sim":1.0, - "partner":"7baw" - }, { "sim":1.0, "partner":"8b16" }, { - "sim":0.9980000257, - "partner":"6g65" - }, - { - "sim":0.9975000024, - "partner":"6g67" + "sim":0.9927999973, + "partner":"6g6a" }, { "sim":1.0, - "partner":"7nfl" - }, - { - "sim":0.9775999784, - "partner":"6yb0" + "partner":"7baw" }, { "sim":0.9860000014, @@ -424758,59 +426628,47 @@ }, { "sim":1.0, - "partner":"6zt1" - }, - { - "sim":1.0, - "partner":"7a1t" + "partner":"7bas" }, { - "sim":1.0, - "partner":"7bas" + "sim":0.9907000065, + "partner":"4pn9" }, { - "sim":1.0, - "partner":"7bav" + "sim":0.989199996, + "partner":"6eiz" }, { "sim":1.0, - "partner":"7nfp" + "partner":"6zt1" }, { "sim":1.0, - "partner":"7nff" + "partner":"7a1t" }, { - "sim":0.989199996, - "partner":"7nfo" + "sim":0.9983000159, + "partner":"8a09" }, { "sim":0.9882000089, "partner":"7nfk" }, { - "sim":0.9862999916, - "partner":"6xy1" - }, - { - "sim":0.9907000065, - "partner":"4pn9" + "sim":1.0, + "partner":"6g69" }, { "sim":0.99150002, "partner":"4pna" }, - { - "sim":0.989199996, - "partner":"6eiz" - }, { "sim":0.9918000102, "partner":"7bim" }, { - "sim":0.9983000159, - "partner":"8a09" + "sim":1.0, + "partner":"7bav" }, { "sim":0.9887999892, @@ -424820,6 +426678,14 @@ "sim":0.9886000156, "partner":"6eik" }, + { + "sim":1.0, + "partner":"7nfl" + }, + { + "sim":0.989199996, + "partner":"7nfo" + }, { "sim":0.9862999916, "partner":"5ezc" @@ -424828,6 +426694,14 @@ "sim":0.9896000028, "partner":"7nfn" }, + { + "sim":0.9862999916, + "partner":"6xy1" + }, + { + "sim":0.9775999784, + "partner":"6yb0" + }, { "sim":0.9527000189, "partner":"5eze" @@ -424836,10 +426710,22 @@ "sim":0.9929000139, "partner":"7nfj" }, + { + "sim":0.9983000159, + "partner":"6g6d" + }, { "sim":0.9940000176, "partner":"7nfh" }, + { + "sim":1.0, + "partner":"6g68" + }, + { + "sim":1.0, + "partner":"6g6c" + }, { "sim":0.9929000139, "partner":"5ez9" @@ -424847,6 +426733,26 @@ { "sim":0.9635999799, "partner":"6yaz" + }, + { + "sim":0.9980000257, + "partner":"6g65" + }, + { + "sim":0.9975000024, + "partner":"6g67" + }, + { + "sim":1.0, + "partner":"7nfp" + }, + { + "sim":0.9656999707, + "partner":"9gf2" + }, + { + "sim":1.0, + "partner":"7nff" } ], "struct_thr_sim_natural":[ @@ -424860,7 +426766,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"6g69" + "partner":"7bo8" }, "struct_max_sim_natural":[ @@ -424923,102 +426829,102 @@ ], "subtitle":"A hexameric de novo coiled-coil assembly: cc-type2-(yafd)4-w19(brphe)", "tags":[ + "coiled coil", "synthetic peptide", "de novo protein", - "coiled coil", - "tyrosine-tyrosine interactions", - "homomeric assembly" + "homomeric assembly", + "tyrosine-tyrosine interactions" ], "keywords":[ - "containing", - "tetramer", - "amphipathic", - "many", + "allow", + "hydrophobic", + "structural", "background", - "use", + "core", + "lead", + "extended", "acid", - "including", - "designed", - "consequences", - "allow", - "requires", - "current", - "generally", - "sequences", + "tyrosine", + "new", + "make", + "folding", + "drive", + "protein", + "network", + "probes", + "binding", + "cc", "\u03b1", - "structure", "networks", - "resolve", - "pack", - "rich", - "however", - "aromatic", - "interfaces", + "novo", "general", - "coiled", - "network", - "cc", - "de", - "advanced", + "catalytic", + "helices", + "rules", + "using", + "complex", + "knowledge", + "antiparallel", + "however", "aliphatic", - "interface", - "targeted", - "drive", - "lead", - "structures", + "accessible", + "residues", + "specific", + "polar", + "ccs", + "subset", "buried", + "useful", + "generally", + "use", + "entirely", "center", + "interface", "coils", - "assembly", - "form", - "rules", - "solvent", - "another", - "amino", "sufficiently", - "assemblies", - "extended", - "ccs", - "catalytic", - "namely", - "would", - "subset", - "useful", - "specific", + "including", + "surface", + "tetramer", "design", - "tyrosine", - "core", + "another", + "current", + "assembly", + "rich", + "fold", + "consequences", + "explore", + "resolve", + "namely", + "amino", + "understood", + "requires", "predominantly", - "using", - "hydrophobic", - "surface", + "assemblies", + "amphipathic", + "folds", + "designed", + "form", "introducing", - "known", - "structural", - "make", + "pack", + "sequences", + "aromatic", + "many", + "interfaces", "one", - "entirely", - "helices", - "accessible", - "novo", + "targeted", + "structures", + "de", "rational", - "fold", - "residues", - "understood", - "folds", - "antiparallel", - "polar", - "explore", + "structure", + "understanding", + "known", + "would", "examples", - "protein", - "complex", - "knowledge", + "coiled", + "solvent", "contribution", - "understanding", - "folding", - "binding", - "probes", - "new" + "containing", + "advanced" ], "release_date":"2021-05-19", "publication":"\"How Coiled-Coil Assemblies Accommodate Multiple Aromatic Residues\", Biomacromolecules, 22, 2010-2019", @@ -425067,10 +426973,6 @@ "sim":1.0, "partner":"6yb2" }, - { - "sim":1.0, - "partner":"6zt1" - }, { "sim":1.0, "partner":"7a1t" @@ -425092,21 +426994,17 @@ "partner":"7nfi" }, { - "sim":0.9775000215, - "partner":"7bau" + "sim":1.0, + "partner":"6zt1" }, { - "sim":0.9986000061, - "partner":"7nfm" + "sim":0.9775000215, + "partner":"7bau" }, { "sim":0.9986000061, "partner":"4pn9" }, - { - "sim":1.0, - "partner":"5ez8" - }, { "sim":0.9855999947, "partner":"6eiz" @@ -425139,33 +427037,33 @@ "sim":1.0, "partner":"7bo8" }, + { + "sim":0.9986000061, + "partner":"7nfm" + }, { "sim":1.0, - "partner":"4pna" + "partner":"5ez8" }, { "sim":0.9940999746, "partner":"6g65" }, - { - "sim":0.9955000281, - "partner":"6g67" - }, - { - "sim":0.9958000183, - "partner":"7bim" - }, { "sim":0.969900012, "partner":"7nfh" }, { "sim":1.0, - "partner":"5ez9" + "partner":"4pna" }, { "sim":1.0, - "partner":"5eza" + "partner":"5ez9" + }, + { + "sim":0.9955000281, + "partner":"6g67" }, { "sim":1.0, @@ -425179,6 +427077,10 @@ "sim":1.0, "partner":"6g6c" }, + { + "sim":0.9958000183, + "partner":"7bim" + }, { "sim":0.9775999784, "partner":"7nfo" @@ -425191,6 +427093,10 @@ "sim":0.975399971, "partner":"6yb0" }, + { + "sim":1.0, + "partner":"5eza" + }, { "sim":0.9940000176, "partner":"7nff" @@ -425211,7 +427117,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"6yb2" + "partner":"7nfj" }, "struct_max_sim_natural":[ @@ -425400,8 +427306,8 @@ ], "subtitle":"Solution nmr structure of nf2; de novo designed protein with a novel fold", "tags":[ - "de novo designed protein", - "de novo protein" + "de novo protein", + "de novo designed protein" ], "keywords":[ "description", @@ -425522,8 +427428,8 @@ ], "subtitle":"Solution nmr structure of nf7; de novo designed protein with a novel fold", "tags":[ - "de novo designed protein", - "de novo protein" + "de novo protein", + "de novo designed protein" ], "keywords":[ "description", @@ -425644,8 +427550,8 @@ ], "subtitle":"Solution nmr structure of nf5; de novo designed protein with a novel fold", "tags":[ - "de novo designed protein", - "de novo protein" + "de novo protein", + "de novo designed protein" ], "keywords":[ "description", @@ -425769,8 +427675,8 @@ ], "subtitle":"Solution nmr structure of nf6; de novo designed protein with a novel fold", "tags":[ - "de novo designed protein", - "de novo protein" + "de novo protein", + "de novo designed protein" ], "keywords":[ "description", @@ -425894,8 +427800,8 @@ ], "subtitle":"Solution nmr structure of nf4; de novo designed protein with a novel fold", "tags":[ - "de novo designed protein", - "de novo protein" + "de novo protein", + "de novo designed protein" ], "keywords":[ "description", @@ -426016,8 +427922,8 @@ ], "subtitle":"Solution nmr structure of nf8 (knot fold); de novo designed protein with a novel fold", "tags":[ - "de novo designed protein", - "de novo protein" + "de novo protein", + "de novo designed protein" ], "keywords":[ "description", @@ -426138,8 +428044,8 @@ ], "subtitle":"Solution nmr structure of nf3; de novo designed protein with a novel fold", "tags":[ - "de novo designed protein", - "de novo protein" + "de novo protein", + "de novo designed protein" ], "keywords":[ "description", @@ -426279,8 +428185,8 @@ ], "subtitle":"Solution nmr structure of fold-0 chantal; de novo designed protein with an asymmetric all-alpha topology", "tags":[ - "de novo designed protein", - "de novo protein" + "de novo protein", + "de novo designed protein" ], "keywords":[ "description", @@ -426416,8 +428322,8 @@ ], "subtitle":"Solution nmr structure of fold-c rei; de novo designed protein with an asymmetric all-alpha topology", "tags":[ - "de novo designed protein", - "de novo protein" + "de novo protein", + "de novo designed protein" ], "keywords":[ "description", @@ -426548,281 +428454,281 @@ ], "subtitle":"Solution nmr structure of fold-z gogy; de novo designed protein with an asymmetric all-alpha topology", - "tags":[ - "de novo designed protein", - "de novo protein" - ], - "keywords":[ - "description", - "found" - ], - "release_date":"2021-04-07", - "publication":"\"Design of complicated all-alpha protein structures\", Nat.Struct.Mol.Biol.", - "publication_ref":{ - "DOI":"10.1038\/s41594-023-01147-9", - "PubMed":"", - "CSD":"", - "ISSN":"1545-9985", - 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"forename":"R.", + "surname":"Koga" + }, + { + "forename":"N.", + "surname":"Koga" + } + ], + "classification":"unknown", + "classification_suggested":[ + + ], + "classification_suggested_reason":[ + + ], + "subtitle":"Solution nmr structure of fold-k mussoc; de novo designed protein with an asymmetric all-alpha topology", + "tags":[ + "de novo protein", + "de novo designed protein" + ], + "keywords":[ + "description", + "found" + ], + "release_date":"2021-04-07", + "publication":"\"Design of complicated all-alpha protein structures\", Nat.Struct.Mol.Biol.", + "publication_ref":{ + "DOI":"10.1038\/s41594-023-01147-9", + "PubMed":"", + "CSD":"", + "ISSN":"1545-9985", + "ASTM":"" + }, + "publication_country":"US", + "abstract":"No description found.", + "crystal_structure":{ + "length_a":"", + "length_b":"", + "length_c":"", + "angle_a":"", + "angle_b":"", + "angle_g":"" + }, + "symmetry":"", + "exptl_method":[ + "SOLUTION NMR" + ], + "formula_weight":15536.427, + "synthesis_comment":"", + "review":true, + "previous_design":"7bqq", + "next_design":"7bqs", + "seq_thr_sim_designed":[ + { + "sim":56.0, + "partner":"5cwb" + } + ], + "seq_thr_sim_natural":[ + + ], + "struct_thr_sim_designed":[ + + ], + "struct_thr_sim_natural":[ + + ], + "seq_max_sim_designed":{ + "sim":56.0, + "partner":"5cwb" + }, + "seq_max_sim_natural":{ + "sim":47.0, + "partner":"6w2q" + }, + "struct_max_sim_designed":{ + "sim":0.461499989, + "partner":"7uqa" + }, + "struct_max_sim_natural":{ + "sim":0.4512000084, + "partner":"3dbj" + }, + "review_comment":[ + "" + ] + }, + { + "pdb":"7bqs", + "picture_path":"https:\/\/cdn.rcsb.org\/images\/structures\/7bqs_assembly-1.jpeg", + "chains":[ + { + "chain_id":"A", + "chain_source":"synthetic construct", + "chain_type":"D", + "chain_seq_unnat":"GETKAKAAQEALRAAREQATTPEAQKALEELEKVLKTASPEQWRQAAEKIFEAFREASNGNTEKAKKLLEEAARTAGASPEIIKKLASALERLAEEGAAKEAARQAEEVRKRGSLEHHHHHH", + "chain_seq_nat":"GETKAKAAQEALRAAREQATTPEAQKALEELEKVLKTASPEQWRQAAEKIFEAFREASNGNTEKAKKLLEEAARTAGASPEIIKKLASALERLAEEGAAKEAARQAEEVRKRGSLEHHHHHH", + "chain_length":123 + } + ], + "authors":[ + { + "forename":"K.", + "surname":"Sakuma" + }, + { + "forename":"N.", + "surname":"Kobayashi" + }, + { + "forename":"T.", + "surname":"Sugiki" + }, + { + "forename":"T.", + "surname":"Nagashima" + }, + { + "forename":"T.", + "surname":"Fujiwara" + }, + { + "forename":"K.", + "surname":"Suzuki" + }, + { + "forename":"N.", + "surname":"Kobayashi" + }, + { + "forename":"T.", + "surname":"Murata" + }, + { + "forename":"T.", + "surname":"Kosugi" + }, + { + "forename":"R.", + "surname":"Koga" + }, + { + "forename":"N.", + "surname":"Koga" + } + ], + "classification":"unknown", + "classification_suggested":[ + + ], + "classification_suggested_reason":[ + + ], + "subtitle":"Solution nmr structure of fold-u nomur; de novo designed protein with an asymmetric all-alpha topology", + "tags":[ + "de novo protein", + "de novo designed proteins" ], "keywords":[ "description", @@ -426955,81 +428861,81 @@ ], "subtitle":"Structure of the engineered metallo-diels-alderase da7 w16s", "tags":[ - "de novo diels-alderase", - "de novo protein" + "de novo protein", + "de novo diels-alderase" ], "keywords":[ - "sites", - "laboratory", - "directions", - "control", - "exciting", - "evolution", - "per", - "capitalize", - "unknown", - "proteins", - "pathway", - "repurposing", - "chemical", - "common", - "approach", - "exerts", - "catalysts", - "strategy", - "de", - "catalytic", - "metal", - "characterized", - "ions", - "novo", - "product", - "displays", - "directed", - "artificial", - "ts", - "enzyme", - "acid", - "properties", - "accelerating", - "4", - "absolute", - "stereochemistry", - "engineered", - "10", - "reactions", - "used", - "highly", - "active", + "turnovers", "reaction", - "may", + "ts", + "effective", + "directed", "propel", - "achieves", - "turnovers", - "abiological", + "engineered", + "design", + "transform", "metalloenzyme", - "nature", - "extension", - "far", - "proficiency", + "characterized", + "catalysis", + "metal", "show", - "design", - "naive", - "previously", - "effective", - "protein", + "extension", + "active", + "reactions", + "used", + "de", "natural", - "transform", - "exceeds", - "lewis", - "usually", - "scaffolds", "functionally", + "field", + "previously", + "properties", + "acid", + "scaffolds", "catalyst", - "catalysis", + "new", + "strategy", + "usually", + "displays", + "control", + "protein", + "nature", + "naive", + "approach", + "product", + "4", + "sites", + "proteins", + "stereochemistry", + "accelerating", + "artificial", + "ions", "site", - "field", - "new" + "proficiency", + "novo", + "may", + "far", + "pathway", + "enzyme", + "highly", + "abiological", + "common", + "absolute", + "laboratory", + "exciting", + "directions", + "catalytic", + "evolution", + "exerts", + "chemical", + "achieves", + "10", + "lewis", + "repurposing", + "capitalize", + "unknown", + "exceeds", + "per", + "catalysts" ], "release_date":"2021-04-21", "publication":"\"Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold\", Nat.Chem., 13, 231-235", @@ -427074,19 +428980,19 @@ }, { "sim":79.0, - "partner":"3v1d" + "partner":"3v1c" }, { "sim":79.0, - "partner":"3v1c" + "partner":"3v1d" }, { "sim":79.0, - "partner":"3v1b" + "partner":"3v1a" }, { "sim":79.0, - "partner":"3v1a" + "partner":"3v1b" }, { "sim":78.0, @@ -427192,98 +429098,98 @@ ], "subtitle":"Crystal structure of a self-assembling galactosylated peptide homodimer", "tags":[ - "self-assembling glycopeptide", + "tyrosine-rich peptide", "de novo protein", "o-glycan modification", - "tyrosine-rich peptide" + "self-assembling glycopeptide" ], "keywords":[ - "evidence", + "glycopeptides", + "role", + "scale", + "hydrogelating", + "hydrogel", "results", - "utilized", - "thus", - "established", - "impacts", - "bonds", - "scaffolds", - "provide", - "dimeric", - "supramolecules", - "potential", - "versatile", - "applicability", - "findings", - "18", - "microscopic", - "structure", - "unusual", - "unconventional", "probing", - "however", - "building", - "monosaccharides", - "glycan", + "impacts", + "stabilization", "biomedical", - "spectroscopic", - "angstrom", - "hydroxyl", - "rheological", + "axial", + "corresponding", + "bearing", + "either", "play", - "process", + "illuminate", + "shows", + "however", + "mechanistic", + "comparison", "influence", - "remains", - "often", + "thus", "particularly", - "biomaterials", - "bonding", - "glycosylations", - "mechanistic", - "scale", - "hydrophilicity", - "corresponding", + "rheological", + "contrary", "tyr", - "either", - "exhibit", - "research", - "shows", - "exemplified", - "role", - "hydrogen", - "obtained", - "stereospecific", - "stereochemistry", - "4", + "exploiting", + "process", + "evidence", + "18", "may", - "glycopeptide", "carbohydrates", - "promotes", - "behavior", - "comparison", - "crystallographic", - "indicate", - "abilities", + "hydrogen", + "established", + "contain", + "microscopic", + "along", + "biomaterials", + "glycan", + "moieties", "unclear", - "stabilization", "gelator", + "obtained", + "applicability", + "promotes", + "bonding", + "spectroscopic", + "behavior", + "exhibit", + "angstrom", + "research", + "potential", + "gelating", + "bonds", + "experiments", + "stereospecific", "groups", - "hydrogelating", + "exemplified", + "utilized", "wide", - "along", - "experiments", - "axial", - "exploiting", + "stereochemistry", + "unconventional", + "supramolecules", + "building", "system", - "illuminate", - "affording", - "hydrogel", - "contrary", - "gelating", - "glycopeptides", - "bearing", - "moieties", - "glycoforms", + "versatile", "developed", - "contain" + "abilities", + "unusual", + "crystallographic", + "glycosylations", + "often", + "glycoforms", + "monosaccharides", + "indicate", + "hydroxyl", + "remains", + "hydrophilicity", + "structure", + "scaffolds", + "provide", + "findings", + "4", + "affording", + "glycopeptide", + "dimeric" ], "release_date":"2020-10-07", "publication":"\"Glycopeptide Self-Assembly Modulated by Glycan Stereochemistry through Glycan-Aromatic Interactions\", J.Am.Chem.Soc., 142, 17015-17023", @@ -427426,138 +429332,138 @@ ], "subtitle":"Crystal structure of a de novo designed switch protein caging a hemagglutinin binder", "tags":[ - "artificial biosensor", "de novo protein", + "artificial biosensor", "six-helical bundle" ], "keywords":[ - "domain", - "background", - "pm", - "clinical", - "luminescent", - "troponin", - "drives", - "respiratory", - "coupling", - "analytes", - "peptide", - "designed", - "receptor", - "switch", - "syndrome", + "open", "limited", - "target", - "show", - "based", - "her2", - "sensor", - "however", - "direct", - "limit", - "power", - "general", - "readout", - "allows", - "acute", - "membrane", - "proteins", - "de", - "clinically", - "binder", - "analyte", - "detection", - "tools", + "molecular", "luminescence", + "development", "number", - "open", - "used", - "detect", - "sensitivity", - "3", - "occurring", - "sensors", - "modularity", - "repurposed", - "naturally", - "simplifies", - "solution", + "show", + "key", + "background", + "well", + "information", + "sensor", + "biosensors", + "new", + "cardiac", + "protein", + "given", + "binding", + "syndrome", + "inverting", + "incorporates", "cellular", - "signal", + "rapid", + "drives", + "thermodynamic", + "general", + "novo", + "b", + "her2", + "coronavirus", + "systems", + "power", + "flow", + "applications", "igg1", - "fc", + "receptor", + "occurring", + "construction", "botulinum", - "molecules", - "systems", - "platform", - "cardiac", + "nucleocapsid", + "however", + "rbd", + "interest", + "closed", + "triggers", + "biological", + "dark", + "level", "reporters", + "functions", + "useful", + "analytes", + "track", + "approach", + "proteins", + "2", + "modular", + "coupling", + "binder", + "activation", + "former", "created", - "need", - "rapid", - "highlights", - "reengineering", - "devices", - "molecular", - "virus", + "spike", + "15", "higher", - "inverting", - "antibody", - "class", - "thermodynamic", + "tools", + "required", + "switches", "1", - "information", + "peptide", + "detection", + "direct", + "need", "challenging", - "4", - "interest", - "useful", - "functions", - "spike", - "nucleocapsid", - "rbd", - "biosensors", "design", - "incorporates", - "applications", - "switches", - "required", - "high", - "neurotoxin", - "severe", - "biological", + "pm", + "used", + "readout", + "highlights", + "acute", + "domain", + "simplifies", "sensitively", - "key", - "dark", + "platform", + "clinical", + "virus", + "wide", + "luminescent", + "solution", + "limit", + "detect", + "modularity", + "allows", + "outputs", + "fc", + "devices", "range", + "repurposed", + "clinically", + "designed", + "naturally", "one", - "coronavirus", - "closed", - "construction", - "former", - "track", - "approach", - "novo", - "wide", - "enable", - "modular", - "well", - "flow", + "reengineering", + "de", + "neurotoxin", + "3", + "based", + "severe", + "respiratory", + "sensitivity", + "target", "state", - "b", - "protein", - "15", - "2", - "given", - "development", - "triggers", + "troponin", + "signal", + "membrane", + "class", + "4", + "analyte", + "molecules", + "enable", + "high", "diagnostic", - "activation", - "antibodies", - "binding", - "outputs", + "sensors", + "switch", "create", - "level", - "new" + "antibodies", + "antibody" ], "release_date":"2020-12-23", "publication":"\"De novo design of modular and tunable protein biosensors\", Nature, 591, 482-487", @@ -427693,105 +429599,105 @@ ], "subtitle":"De novo design protein xm2h", "tags":[ - "monomer", + "ferredoxin-like", "de novo protein", - "ferredoxin-like" + "monomer" ], "keywords":[ - "indicating", - "thus", - "established", - "use", - "comprehensive", - "selection", - "acid", - "designed", - "uses", - "crystal", - "eschewing", - "exist", - "based", + "molecular", + "whose", + "novelty", + "number", "show", - "sampling", - "sequences", - "interactions", + "amenable", + "side", + "precision", + "acid", + "new", + "model", + "protein", + "autonomously", + "network", + "neural", + "continuous", + "novo", "precise", - "suggested", - "scuba", - "designing", - "represent", - "structure", - "diversity", + "crystal", + "using", + "learned", + "goal", + "terms", "however", "backbones", + "purpose", + "overall", + "thus", + "comprises", + "comprehensive", "novel", - "amenable", - "statistical", - "architectures", - "chain", - "network", - "proteins", - "training", - "de", - "designability", - "correlations", - "goal", - "number", - "yet", - "whose", - "autonomously", - "kernel", - "structures", - "facilitates", - "function", - "governed", - "learned", "designable", - "estimation", - "molecular", - "amino", + "optimization", + "approach", + "proteins", + "use", + "established", + "density", + "eschewing", + "analytically", + "four", "sufficiently", "substantial", - "report", - "continuous", - "four", - "exploration", - "optimization", - "fragments", + "surface", + "designing", "mainly", "design", - "model", - "followed", - "using", - "existing", - "surface", - "neural", - "high", + "sampling", "energy", - "known", - "ready", - "novelty", - "analytically", - "density", - "overall", - "arrangement", - "purpose", - "approach", - "novo", + "governed", + "chain", + "selection", + "correlations", "named", - "fold", - "precision", + "represent", + "yet", "multidimensional", - "terms", - "comprises", - "protein", - "backbone", + "fold", + "indicating", + "diversity", + "designability", + "amino", + "architectures", "met", + "backbone", + "arrangement", + "uses", + "suggested", + "exist", + "designed", + "extending", + "ready", + "sequences", "space", + "structures", + "de", + "fragments", + "training", + "based", + "structure", "nine", - "extending", - "side", - "new" + "report", + "estimation", + "interactions", + "exploration", + "followed", + "function", + "known", + "facilitates", + "high", + "existing", + "scuba", + "kernel", + "statistical" ], "release_date":"2021-12-08", "publication":"\"A backbone-centred energy function of neural networks for protein design\", Nature, 602, 523-528", @@ -427919,105 +429825,105 @@ ], "subtitle":"De novo design protein am2m", "tags":[ - "monomer", + "ferredoxin-like", "de novo protein", - "ferredoxin-like" + "monomer" ], "keywords":[ - "indicating", - "thus", - "established", - "use", - "comprehensive", - "selection", - "acid", - "designed", - "uses", - "crystal", - "eschewing", - "exist", - "based", + "molecular", + "whose", + "novelty", + "number", "show", - "sampling", - "sequences", - "interactions", + "amenable", + "side", + "precision", + "acid", + "new", + "model", + "protein", + "autonomously", + "network", + "neural", + "continuous", + "novo", "precise", - "suggested", - "scuba", - "designing", - "represent", - "structure", - "diversity", + "crystal", + "using", + "learned", + "goal", + "terms", "however", "backbones", + "purpose", + "overall", + "thus", + "comprises", + "comprehensive", "novel", - "amenable", - "statistical", - "architectures", - "chain", - "network", - "proteins", - "training", - "de", - "designability", - "correlations", - "goal", - "number", - "yet", - "whose", - "autonomously", - "kernel", - "structures", - "facilitates", - "function", - "governed", - "learned", "designable", - "estimation", - "molecular", - "amino", + "optimization", + "approach", + "proteins", + "use", + "established", + "density", + "eschewing", + "analytically", + "four", "sufficiently", "substantial", - "report", - "continuous", - "four", - "exploration", - "optimization", - "fragments", + "surface", + "designing", "mainly", "design", - "model", - "followed", - "using", - "existing", - "surface", - "neural", - "high", + "sampling", "energy", - "known", - "ready", - "novelty", - "analytically", - "density", - "overall", - "arrangement", - "purpose", - "approach", - "novo", + "governed", + "chain", + "selection", + "correlations", "named", - "fold", - "precision", + "represent", + "yet", "multidimensional", - "terms", - "comprises", - "protein", - "backbone", + "fold", + "indicating", + "diversity", + "designability", + "amino", + "architectures", "met", + "backbone", + "arrangement", + "uses", + "suggested", + "exist", + "designed", + "extending", + "ready", + "sequences", "space", + "structures", + "de", + "fragments", + "training", + "based", + "structure", "nine", - "extending", - "side", - "new" + "report", + "estimation", + "interactions", + "exploration", + "followed", + "function", + "known", + "facilitates", + "high", + "existing", + "scuba", + "kernel", + "statistical" ], "release_date":"2021-12-08", "publication":"\"A backbone-centred energy function of neural networks for protein design\", Nature, 602, 523-528", @@ -428142,104 +430048,104 @@ ], "subtitle":"A de novo protein that rigidly extends the structure of tvhs-like domain in tepsin with a new designed domain", "tags":[ - "all helix", - "de novo protein" + "de novo protein", + "all helix" ], "keywords":[ - "indicating", - "thus", - "established", - "use", - "comprehensive", - "selection", - "acid", - "designed", - "uses", - "crystal", - "eschewing", - "exist", - "based", + "molecular", + "whose", + "novelty", + "number", "show", - "sampling", - "sequences", - "interactions", + "amenable", + "side", + "precision", + "acid", + "new", + "model", + "protein", + "autonomously", + "network", + "neural", + "continuous", + "novo", "precise", - "suggested", - "scuba", - "designing", - "represent", - "structure", - "diversity", + "crystal", + "using", + "learned", + "goal", + "terms", "however", "backbones", + "purpose", + "overall", + "thus", + "comprises", + "comprehensive", "novel", - "amenable", - "statistical", - "architectures", - "chain", - "network", - "proteins", - "training", - "de", - "designability", - "correlations", - "goal", - "number", - "yet", - "whose", - "autonomously", - "kernel", - "structures", - "facilitates", - "function", - "governed", - "learned", "designable", - "estimation", - "molecular", - "amino", + "optimization", + "approach", + "proteins", + "use", + "established", + "density", + "eschewing", + "analytically", + "four", "sufficiently", "substantial", - "report", - "continuous", - "four", - "exploration", - "optimization", - "fragments", + "surface", + "designing", "mainly", "design", - "model", - "followed", - "using", - "existing", - "surface", - "neural", - "high", + "sampling", "energy", - "known", - "ready", - "novelty", - "analytically", - "density", - "overall", - "arrangement", - "purpose", - "approach", - "novo", + "governed", + "chain", + "selection", + "correlations", "named", - "fold", - "precision", + "represent", + "yet", "multidimensional", - "terms", - "comprises", - "protein", - "backbone", + "fold", + "indicating", + "diversity", + "designability", + "amino", + "architectures", "met", + "backbone", + "arrangement", + "uses", + "suggested", + "exist", + "designed", + "extending", + "ready", + "sequences", "space", + "structures", + "de", + "fragments", + "training", + "based", + "structure", "nine", - "extending", - "side", - "new" + "report", + "estimation", + "interactions", + "exploration", + "followed", + "function", + "known", + "facilitates", + "high", + "existing", + "scuba", + "kernel", + "statistical" ], "release_date":"2021-12-08", "publication":"\"A backbone-centred energy function of neural networks for protein design\", Nature, 602, 523-528", @@ -428439,85 +430345,85 @@ ], "subtitle":"Darpin 5m3_d12 in complex with v3-iy (mn) crown mimetic", "tags":[ - "anti-hiv", "designed ankyrin repeat proteins", - "protein engineering", "de novo protein", - "protein design" + "protein engineering", + "protein design", + "anti-hiv" ], "keywords":[ - "responses", - "neutralization", - "prefusion", + "designed", + "env", + "open", "largely", - "triggered", + "breadth", + "achieve", + "directed", "analysis", - "k", - "rare", + "responses", "preventive", - "cohort", - "results", + "challenging", + "conclusion", + "prefusion", + "revealed", + "conserved", "one", - "proteins", - "accessible", - "attacked", + "indicate", + "role", "conformational", - "neutralizing", - "n", - "focusing", + "repeat", + "loop", + "show", + "development", + "vigorous", + "engagement", + "v3", "bnab", - "antibody", - "principle", - "response", + "approaches", + "cohort", "elicits", - "conserved", - "directed", - "reactivities", - "designed", - "challenging", - "open", - "ankyrin", + "accessible", "residues", - "highly", - "swiss", - "approaches", - "envelope", - "two", - "activity", - "breadth", - "target", + "preferences", + "n", + "results", "considered", - "show", - "env", + "therapeutic", + "target", + "resembles", "protein", "bind", - "conclusion", - "present", - "view", - "engagement", - "supporting", - "resembles", - "development", + "cd4", + "swiss", + "response", + "proteins", + "binding", + "reactivities", "matching", - "bnds", - "repeat", - "revealed", - "indicate", - "vigorous", - "v3", + "ankyrin", + "rare", + "activity", "broadly", + "highly", + "neutralization", + "view", + "neutralizing", + "bnds", + "focusing", "distinct", - "cd4", - "antibodies", - "role", - "achieve", "conformations", - "binding", - "preferences", - "therapeutic", - "loop", + "two", + "principle", + "present", + "whereas", + "envelope", + "k", "bnabs", - "whereas" + "triggered", + "attacked", + "supporting", + "antibodies", + "antibody" ], "release_date":"2021-12-22", "publication":"\"Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization\", Nat Commun, 12, 6705-6705", @@ -428578,7 +430484,7 @@ }, { "sim":290.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":290.0, @@ -428586,7 +430492,7 @@ }, { "sim":290.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":288.0, @@ -428626,47 +430532,47 @@ }, { "sim":254.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":254.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":254.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":254.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":254.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":254.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":254.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":254.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":254.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":254.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":254.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":254.0, @@ -428674,15 +430580,15 @@ }, { "sim":254.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":254.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":254.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":252.0, @@ -428710,15 +430616,15 @@ }, { "sim":246.0, - "partner":"7b4t" + "partner":"6fpb" }, { "sim":246.0, - "partner":"6fpb" + "partner":"6fpa" }, { "sim":246.0, - "partner":"6fpa" + "partner":"7b4t" }, { "sim":246.0, @@ -428806,11 +430712,11 @@ }, { "sim":223.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":223.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":223.0, @@ -428846,11 +430752,11 @@ }, { "sim":186.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":186.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":183.0, @@ -428876,6 +430782,10 @@ "sim":170.0, "partner":"8ak1" }, + { + "sim":168.0, + "partner":"9glq" + }, { "sim":167.0, "partner":"8aiw" @@ -429044,31 +430954,27 @@ }, { "sim":254.0, - "partner":"5eno" - }, - { - "sim":254.0, - "partner":"6zob" + "partner":"4dx6" }, { "sim":254.0, - "partner":"6zo5" + "partner":"6mzf" }, { "sim":254.0, - "partner":"6mzf" + "partner":"6sgs" }, { "sim":254.0, - "partner":"4dx6" + "partner":"6zoc" }, { "sim":254.0, - "partner":"6q4n" + "partner":"6mze" }, { "sim":254.0, - "partner":"6zoc" + "partner":"6zo6" }, { "sim":254.0, @@ -429080,27 +430986,27 @@ }, { "sim":254.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":254.0, - "partner":"6mze" + "partner":"7ac5" }, { "sim":254.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":254.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":254.0, - "partner":"5nqu" + "partner":"4dx7" }, { "sim":254.0, - "partner":"6q4o" + "partner":"5nqu" }, { "sim":254.0, @@ -429108,15 +431014,11 @@ }, { "sim":254.0, - "partner":"6zod" - }, - { - "sim":254.0, - "partner":"7ac5" + "partner":"6zo7" }, { "sim":254.0, - "partner":"7b8r" + "partner":"6zoe" }, { "sim":254.0, @@ -429124,19 +431026,15 @@ }, { "sim":254.0, - "partner":"6zo7" - }, - { - "sim":254.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":254.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":254.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":254.0, @@ -429148,19 +431046,19 @@ }, { "sim":254.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":254.0, - "partner":"4lnu" + "partner":"6zof" }, { "sim":254.0, - "partner":"6zo8" + "partner":"4lnu" }, { "sim":254.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":254.0, @@ -429172,23 +431070,23 @@ }, { "sim":254.0, - "partner":"6sgu" + "partner":"7b8t" }, { "sim":254.0, - "partner":"5nc5" + "partner":"6zo9" }, { "sim":254.0, - "partner":"6zo9" + "partner":"6zog" }, { "sim":254.0, - "partner":"6zog" + "partner":"5nc5" }, { "sim":254.0, - "partner":"7b8t" + "partner":"6zwb" }, { "sim":254.0, @@ -429208,27 +431106,27 @@ }, { "sim":254.0, - "partner":"6zwb" + "partner":"5en5" }, { "sim":254.0, - "partner":"5en5" + "partner":"6zoa" }, { "sim":254.0, - "partner":"4u8y" + "partner":"6zoh" }, { "sim":254.0, - "partner":"6zoa" + "partner":"6zwc" }, { "sim":254.0, - "partner":"6zoh" + "partner":"4u8y" }, { "sim":254.0, - "partner":"6zwc" + "partner":"6sgr" }, { "sim":254.0, @@ -429244,12 +431142,24 @@ }, { "sim":254.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":254.0, "partner":"4dx5" }, + { + "sim":254.0, + "partner":"5eno" + }, + { + "sim":254.0, + "partner":"6zo5" + }, + { + "sim":254.0, + "partner":"6q4n" + }, { "sim":254.0, "partner":"5mla" @@ -429264,11 +431174,11 @@ }, { "sim":252.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":252.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":252.0, @@ -429332,11 +431242,11 @@ }, { "sim":247.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":247.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":247.0, @@ -429464,11 +431374,11 @@ }, { "sim":229.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":229.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":227.0, @@ -429500,11 +431410,11 @@ }, { "sim":212.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":212.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":212.0, @@ -429572,15 +431482,15 @@ }, { "sim":187.0, - "partner":"6d66" + "partner":"2y0b" }, { "sim":187.0, - "partner":"6d67" + "partner":"6d66" }, { "sim":187.0, - "partner":"2y0b" + "partner":"6d67" }, { "sim":185.0, @@ -429742,10 +431652,6 @@ "sim":102.0, "partner":"6by9" }, - { - "sim":101.0, - "partner":"5vhj" - }, { "sim":101.0, "partner":"5vhh" @@ -429774,6 +431680,10 @@ "sim":101.0, "partner":"5vho" }, + { + "sim":101.0, + "partner":"5vhj" + }, { "sim":101.0, "partner":"5vhp" @@ -429804,15 +431714,15 @@ }, { "sim":100.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":100.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":100.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":99.0, @@ -429824,11 +431734,11 @@ }, { "sim":98.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":98.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":93.0, @@ -429840,11 +431750,11 @@ }, { "sim":93.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":93.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":93.0, @@ -430030,14 +431940,6 @@ "sim":83.0, "partner":"6py8" }, - { - "sim":82.0, - "partner":"6m11" - }, - { - "sim":82.0, - "partner":"6m12" - }, { "sim":82.0, "partner":"6m13" @@ -430062,6 +431964,14 @@ "sim":82.0, "partner":"4o1p" }, + { + "sim":82.0, + "partner":"6m11" + }, + { + "sim":82.0, + "partner":"6m12" + }, { "sim":81.0, "partner":"2rfm" @@ -430160,19 +432070,19 @@ }, { "sim":76.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":76.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":76.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":76.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":76.0, @@ -430186,10 +432096,6 @@ "sim":76.0, "partner":"3uxg" }, - { - "sim":75.0, - "partner":"6v9x" - }, { "sim":75.0, "partner":"6v9y" @@ -430202,6 +432108,10 @@ "sim":75.0, "partner":"6v9w" }, + { + "sim":75.0, + "partner":"6v9x" + }, { "sim":75.0, "partner":"6pqo" @@ -430308,11 +432218,11 @@ }, { "sim":66.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":66.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":66.0, @@ -430368,15 +432278,15 @@ }, { "sim":59.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":59.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":59.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":59.0, @@ -430454,6 +432364,10 @@ "sim":51.0, "partner":"1oy3" }, + { + "sim":51.0, + "partner":"8ycp" + }, { "sim":51.0, "partner":"7lqy" @@ -430959,85 +432873,85 @@ ], "subtitle":"Darpin 63_b7 in complex with v3-iy (mn) crown mimetic", "tags":[ - "anti-hiv", "designed ankyrin repeat proteins", - "protein engineering", "de novo protein", - "protein design" + "protein engineering", + "protein design", + "anti-hiv" ], "keywords":[ - "responses", - "neutralization", - "prefusion", + "designed", + "env", + "open", "largely", - "triggered", + "breadth", + "achieve", + "directed", "analysis", - "k", - "rare", + "responses", "preventive", - "cohort", - "results", + "challenging", + "conclusion", + "prefusion", + "revealed", + "conserved", "one", - "proteins", - "accessible", - "attacked", + "indicate", + "role", "conformational", - "neutralizing", - "n", - "focusing", + "repeat", + "loop", + "show", + "development", + "vigorous", + "engagement", + "v3", "bnab", - "antibody", - "principle", - "response", + "approaches", + "cohort", "elicits", - "conserved", - "directed", - "reactivities", - "designed", - "challenging", - "open", - "ankyrin", + "accessible", "residues", - "highly", - "swiss", - "approaches", - "envelope", - "two", - "activity", - "breadth", - "target", + "preferences", + "n", + "results", "considered", - "show", - "env", + "therapeutic", + "target", + "resembles", "protein", "bind", - "conclusion", - "present", - "view", - "engagement", - "supporting", - "resembles", - "development", + "cd4", + "swiss", + "response", + "proteins", + "binding", + "reactivities", "matching", - "bnds", - "repeat", - "revealed", - "indicate", - "vigorous", - "v3", + "ankyrin", + "rare", + "activity", "broadly", + "highly", + "neutralization", + "view", + "neutralizing", + "bnds", + "focusing", "distinct", - "cd4", - "antibodies", - "role", - "achieve", "conformations", - "binding", - "preferences", - "therapeutic", - "loop", + "two", + "principle", + "present", + "whereas", + "envelope", + "k", "bnabs", - "whereas" + "triggered", + "attacked", + "supporting", + "antibodies", + "antibody" ], "release_date":"2021-12-15", "publication":"\"Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization\", Nat Commun, 12, 6705-6705", @@ -431074,19 +432988,19 @@ }, { "sim":299.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":299.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":299.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":299.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":299.0, @@ -431094,35 +433008,35 @@ }, { "sim":299.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":299.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":299.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":299.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":299.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":299.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":299.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":299.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":294.0, @@ -431146,11 +433060,11 @@ }, { "sim":283.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":283.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":282.0, @@ -431210,11 +433124,11 @@ }, { "sim":257.0, - "partner":"7z72" + "partner":"7z71" }, { "sim":257.0, - "partner":"7z71" + "partner":"7z72" }, { "sim":257.0, @@ -431266,7 +433180,7 @@ }, { "sim":250.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":250.0, @@ -431274,15 +433188,15 @@ }, { "sim":250.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":249.0, - "partner":"7dne" + "partner":"2xee" }, { "sim":249.0, - "partner":"2xee" + "partner":"7dne" }, { "sim":247.0, @@ -431294,11 +433208,11 @@ }, { "sim":244.0, - "partner":"8a1a" + "partner":"8a19" }, { "sim":244.0, - "partner":"8a19" + "partner":"8a1a" }, { "sim":243.0, @@ -431342,11 +433256,11 @@ }, { "sim":218.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":218.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":218.0, @@ -431370,11 +433284,11 @@ }, { "sim":196.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":196.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":194.0, @@ -431392,6 +433306,10 @@ "sim":192.0, "partner":"4qfv" }, + { + "sim":183.0, + "partner":"9glq" + }, { "sim":178.0, "partner":"4hqd" @@ -431442,13 +433360,17 @@ "sim":299.0, "partner":"6mzf" }, + { + "sim":299.0, + "partner":"6mze" + }, { "sim":299.0, "partner":"5nqt" }, { "sim":299.0, - "partner":"6mze" + "partner":"7ac5" }, { "sim":299.0, @@ -431460,11 +433382,11 @@ }, { "sim":299.0, - "partner":"7ac5" + "partner":"4lnu" }, { "sim":299.0, - "partner":"4lnu" + "partner":"6zwb" }, { "sim":299.0, @@ -431474,10 +433396,6 @@ "sim":299.0, "partner":"5nm5" }, - { - "sim":299.0, - "partner":"6zwb" - }, { "sim":299.0, "partner":"6zwc" @@ -431510,45 +433428,25 @@ "sim":294.0, "partner":"5eib" }, - { - "sim":293.0, - "partner":"5eno" - }, - { - "sim":293.0, - "partner":"6zob" - }, - { - "sim":293.0, - "partner":"6zo5" - }, { "sim":293.0, "partner":"4dx6" }, { "sim":293.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":293.0, "partner":"6zoc" }, - { - "sim":293.0, - "partner":"5enp" - }, - { - "sim":293.0, - "partner":"6sgs" - }, { "sim":293.0, "partner":"6zo6" }, { "sim":293.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":293.0, @@ -431556,7 +433454,7 @@ }, { "sim":293.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":293.0, @@ -431564,11 +433462,11 @@ }, { "sim":293.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":293.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":293.0, @@ -431578,6 +433476,10 @@ "sim":293.0, "partner":"6zoe" }, + { + "sim":293.0, + "partner":"5enq" + }, { "sim":293.0, "partner":"6q4p" @@ -431588,15 +433490,15 @@ }, { "sim":293.0, - "partner":"2j8s" + "partner":"7b8s" }, { "sim":293.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":293.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":293.0, @@ -431608,19 +433510,19 @@ }, { "sim":293.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":293.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":293.0, - "partner":"6sgu" + "partner":"4u8v" }, { "sim":293.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":293.0, @@ -431632,7 +433534,7 @@ }, { "sim":293.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":293.0, @@ -431644,15 +433546,19 @@ }, { "sim":293.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":293.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":293.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":293.0, + "partner":"6sgr" }, { "sim":293.0, @@ -431668,12 +433574,24 @@ }, { "sim":293.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":293.0, "partner":"4dx5" }, + { + "sim":293.0, + "partner":"5eno" + }, + { + "sim":293.0, + "partner":"6zo5" + }, + { + "sim":293.0, + "partner":"6q4n" + }, { "sim":292.0, "partner":"5eyl" @@ -431686,10 +433604,6 @@ "sim":292.0, "partner":"6gvn" }, - { - "sim":291.0, - "partner":"5oyj" - }, { "sim":291.0, "partner":"2bkk" @@ -431702,6 +433616,10 @@ "sim":291.0, "partner":"3nog" }, + { + "sim":291.0, + "partner":"5oyj" + }, { "sim":290.0, "partner":"3noc" @@ -431780,11 +433698,11 @@ }, { "sim":271.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":271.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":270.0, @@ -431816,11 +433734,11 @@ }, { "sim":264.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":264.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":264.0, @@ -431972,11 +433890,11 @@ }, { "sim":237.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":237.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":237.0, @@ -431984,11 +433902,11 @@ }, { "sim":235.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":235.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":234.0, @@ -432044,15 +433962,15 @@ }, { "sim":228.0, - "partner":"6d66" + "partner":"2y0b" }, { "sim":228.0, - "partner":"6d67" + "partner":"6d66" }, { "sim":228.0, - "partner":"2y0b" + "partner":"6d67" }, { "sim":228.0, @@ -432234,10 +434152,6 @@ "sim":105.0, "partner":"4b93" }, - { - "sim":103.0, - "partner":"5vhj" - }, { "sim":103.0, "partner":"5vhh" @@ -432266,6 +434180,10 @@ "sim":103.0, "partner":"5vho" }, + { + "sim":103.0, + "partner":"5vhj" + }, { "sim":103.0, "partner":"5vhp" @@ -432296,15 +434214,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":100.0, @@ -432348,11 +434266,11 @@ }, { "sim":98.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":98.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":97.0, @@ -432404,11 +434322,11 @@ }, { "sim":95.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":95.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":95.0, @@ -432456,15 +434374,15 @@ }, { "sim":90.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":90.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":90.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":90.0, @@ -432618,14 +434536,6 @@ "sim":80.0, "partner":"1s70" }, - { - "sim":80.0, - "partner":"6m11" - }, - { - "sim":80.0, - "partner":"6m12" - }, { "sim":80.0, "partner":"6m13" @@ -432651,8 +434561,12 @@ "partner":"4o1p" }, { - "sim":79.0, - "partner":"6v9x" + "sim":80.0, + "partner":"6m11" + }, + { + "sim":80.0, + "partner":"6m12" }, { "sim":79.0, @@ -432666,6 +434580,10 @@ "sim":79.0, "partner":"6v9w" }, + { + "sim":79.0, + "partner":"6v9x" + }, { "sim":79.0, "partner":"6pqo" @@ -432684,19 +434602,19 @@ }, { "sim":78.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":78.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":78.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":78.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":78.0, @@ -432748,11 +434666,11 @@ }, { "sim":74.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":74.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":74.0, @@ -432826,10 +434744,6 @@ "sim":71.0, "partner":"5dne" }, - { - "sim":70.0, - "partner":"2a5e" - }, { "sim":70.0, "partner":"1dc2" @@ -432840,15 +434754,15 @@ }, { "sim":70.0, - "partner":"6mca" + "partner":"2a5e" }, { "sim":70.0, - "partner":"5wo6" + "partner":"6mca" }, { "sim":70.0, - "partner":"5iwr" + "partner":"5wo6" }, { "sim":70.0, @@ -432904,15 +434818,15 @@ }, { "sim":70.0, - "partner":"5wo7" + "partner":"5iwr" }, { - "sim":69.0, - "partner":"6if3" + "sim":70.0, + "partner":"5wo7" }, { "sim":69.0, - "partner":"6o1p" + "partner":"6if3" }, { "sim":69.0, @@ -432950,6 +434864,10 @@ "sim":69.0, "partner":"6dmw" }, + { + "sim":69.0, + "partner":"6o1p" + }, { "sim":68.0, "partner":"5cer" @@ -432970,10 +434888,6 @@ "sim":63.0, "partner":"8pef" }, - { - "sim":63.0, - "partner":"7k4a" - }, { "sim":63.0, "partner":"7k4b" @@ -432996,7 +434910,7 @@ }, { "sim":63.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":63.0, @@ -433012,11 +434926,11 @@ }, { "sim":63.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":63.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":63.0, @@ -433034,6 +434948,10 @@ "sim":63.0, "partner":"6bo8" }, + { + "sim":63.0, + "partner":"6bo9" + }, { "sim":62.0, "partner":"6ghm" @@ -433138,10 +435056,6 @@ "sim":51.0, "partner":"6uw4" }, - { - "sim":51.0, - "partner":"6mhw" - }, { "sim":51.0, "partner":"6mhx" @@ -433157,6 +435071,10 @@ { "sim":51.0, "partner":"6mhv" + }, + { + "sim":51.0, + "partner":"6mhw" } ], "struct_thr_sim_designed":[ @@ -433174,10 +435092,6 @@ } ], "struct_thr_sim_natural":[ - { - "sim":0.9508000016, - "partner":"5oov" - }, { "sim":0.9562000036, "partner":"6gvm" @@ -433186,14 +435100,6 @@ "sim":0.9581999779, "partner":"4hna" }, - { - "sim":0.9689000249, - "partner":"4hll" - }, - { - "sim":0.9724000096, - "partner":"5gik" - }, { "sim":0.9569000006, "partner":"5ma8" @@ -433202,6 +435108,14 @@ "sim":0.9502999783, "partner":"5ma6" }, + { + "sim":0.9689000249, + "partner":"4hll" + }, + { + "sim":0.9724000096, + "partner":"5gik" + }, { "sim":0.9514999986, "partner":"5ooy" @@ -433213,6 +435127,10 @@ { "sim":0.9524999857, "partner":"4jb8" + }, + { + "sim":0.9508000016, + "partner":"5oov" } ], "seq_max_sim_designed":{ @@ -433367,85 +435285,85 @@ ], "subtitle":"Darpin 63_b7 in complex with linear v3-crown (mn) peptide", "tags":[ - "anti-hiv", "designed ankyrin repeat proteins", - "protein engineering", "de novo protein", - "protein design" + "protein engineering", + "protein design", + "anti-hiv" ], "keywords":[ - "responses", - "neutralization", - "prefusion", + "designed", + "env", + "open", "largely", - "triggered", + "breadth", + "achieve", + "directed", "analysis", - "k", - "rare", + "responses", "preventive", - "cohort", - "results", + "challenging", + "conclusion", + "prefusion", + "revealed", + "conserved", "one", - "proteins", - "accessible", - "attacked", + "indicate", + "role", "conformational", - "neutralizing", - "n", - "focusing", + "repeat", + "loop", + "show", + "development", + "vigorous", + "engagement", + "v3", "bnab", - "antibody", - "principle", - "response", + "approaches", + "cohort", "elicits", - "conserved", - "directed", - "reactivities", - "designed", - "challenging", - "open", - "ankyrin", + "accessible", "residues", - "highly", - "swiss", - "approaches", - "envelope", - "two", - "activity", - "breadth", - "target", + "preferences", + "n", + "results", "considered", - "show", - "env", + "therapeutic", + "target", + "resembles", "protein", "bind", - "conclusion", - "present", - "view", - "engagement", - "supporting", - "resembles", - "development", + "cd4", + "swiss", + "response", + "proteins", + "binding", + "reactivities", "matching", - "bnds", - "repeat", - "revealed", - "indicate", - "vigorous", - "v3", + "ankyrin", + "rare", + "activity", "broadly", + "highly", + "neutralization", + "view", + "neutralizing", + "bnds", + "focusing", "distinct", - "cd4", - "antibodies", - "role", - "achieve", "conformations", - "binding", - "preferences", - "therapeutic", - "loop", + "two", + "principle", + "present", + "whereas", + "envelope", + "k", "bnabs", - "whereas" + "triggered", + "attacked", + "supporting", + "antibodies", + "antibody" ], "release_date":"2021-12-15", "publication":"\"Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization\", Nat Commun, 12, 6705-6705", @@ -433482,19 +435400,19 @@ }, { "sim":299.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":299.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":299.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":299.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":299.0, @@ -433502,35 +435420,35 @@ }, { "sim":299.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":299.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":299.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":299.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":299.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":299.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":299.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":299.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":294.0, @@ -433554,11 +435472,11 @@ }, { "sim":283.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":283.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":282.0, @@ -433618,11 +435536,11 @@ }, { "sim":257.0, - "partner":"7z72" + "partner":"7z71" }, { "sim":257.0, - "partner":"7z71" + "partner":"7z72" }, { "sim":257.0, @@ -433674,7 +435592,7 @@ }, { "sim":250.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":250.0, @@ -433682,15 +435600,15 @@ }, { "sim":250.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":249.0, - "partner":"7dne" + "partner":"2xee" }, { "sim":249.0, - "partner":"2xee" + "partner":"7dne" }, { "sim":247.0, @@ -433702,11 +435620,11 @@ }, { "sim":244.0, - "partner":"8a1a" + "partner":"8a19" }, { "sim":244.0, - "partner":"8a19" + "partner":"8a1a" }, { "sim":243.0, @@ -433750,11 +435668,11 @@ }, { "sim":218.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":218.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":218.0, @@ -433778,11 +435696,11 @@ }, { "sim":196.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":196.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":194.0, @@ -433800,6 +435718,10 @@ "sim":192.0, "partner":"4qfv" }, + { + "sim":183.0, + "partner":"9glq" + }, { "sim":178.0, "partner":"4hqd" @@ -433850,13 +435772,17 @@ "sim":299.0, "partner":"6mzf" }, + { + "sim":299.0, + "partner":"6mze" + }, { "sim":299.0, "partner":"5nqt" }, { "sim":299.0, - "partner":"6mze" + "partner":"7ac5" }, { "sim":299.0, @@ -433868,11 +435794,11 @@ }, { "sim":299.0, - "partner":"7ac5" + "partner":"4lnu" }, { "sim":299.0, - "partner":"4lnu" + "partner":"6zwb" }, { "sim":299.0, @@ -433882,10 +435808,6 @@ "sim":299.0, "partner":"5nm5" }, - { - "sim":299.0, - "partner":"6zwb" - }, { "sim":299.0, "partner":"6zwc" @@ -433918,45 +435840,25 @@ "sim":294.0, "partner":"5eib" }, - { - "sim":293.0, - "partner":"5eno" - }, - { - "sim":293.0, - "partner":"6zob" - }, - { - "sim":293.0, - "partner":"6zo5" - }, { "sim":293.0, "partner":"4dx6" }, { "sim":293.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":293.0, "partner":"6zoc" }, - { - "sim":293.0, - "partner":"5enp" - }, - { - "sim":293.0, - "partner":"6sgs" - }, { "sim":293.0, "partner":"6zo6" }, { "sim":293.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":293.0, @@ -433964,7 +435866,7 @@ }, { "sim":293.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":293.0, @@ -433972,11 +435874,11 @@ }, { "sim":293.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":293.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":293.0, @@ -433986,6 +435888,10 @@ "sim":293.0, "partner":"6zoe" }, + { + "sim":293.0, + "partner":"5enq" + }, { "sim":293.0, "partner":"6q4p" @@ -433996,15 +435902,15 @@ }, { "sim":293.0, - "partner":"2j8s" + "partner":"7b8s" }, { "sim":293.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":293.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":293.0, @@ -434016,19 +435922,19 @@ }, { "sim":293.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":293.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":293.0, - "partner":"6sgu" + "partner":"4u8v" }, { "sim":293.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":293.0, @@ -434040,7 +435946,7 @@ }, { "sim":293.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":293.0, @@ -434052,15 +435958,19 @@ }, { "sim":293.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":293.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":293.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":293.0, + "partner":"6sgr" }, { "sim":293.0, @@ -434076,12 +435986,24 @@ }, { "sim":293.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":293.0, "partner":"4dx5" }, + { + "sim":293.0, + "partner":"5eno" + }, + { + "sim":293.0, + "partner":"6zo5" + }, + { + "sim":293.0, + "partner":"6q4n" + }, { "sim":292.0, "partner":"5eyl" @@ -434094,10 +436016,6 @@ "sim":292.0, "partner":"6gvn" }, - { - "sim":291.0, - "partner":"5oyj" - }, { "sim":291.0, "partner":"2bkk" @@ -434110,6 +436028,10 @@ "sim":291.0, "partner":"3nog" }, + { + "sim":291.0, + "partner":"5oyj" + }, { "sim":290.0, "partner":"3noc" @@ -434188,11 +436110,11 @@ }, { "sim":271.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":271.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":270.0, @@ -434224,11 +436146,11 @@ }, { "sim":264.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":264.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":264.0, @@ -434380,11 +436302,11 @@ }, { "sim":237.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":237.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":237.0, @@ -434392,11 +436314,11 @@ }, { "sim":235.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":235.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":234.0, @@ -434452,15 +436374,15 @@ }, { "sim":228.0, - "partner":"6d66" + "partner":"2y0b" }, { "sim":228.0, - "partner":"6d67" + "partner":"6d66" }, { "sim":228.0, - "partner":"2y0b" + "partner":"6d67" }, { "sim":228.0, @@ -434642,10 +436564,6 @@ "sim":105.0, "partner":"4b93" }, - { - "sim":103.0, - "partner":"5vhj" - }, { "sim":103.0, "partner":"5vhh" @@ -434674,6 +436592,10 @@ "sim":103.0, "partner":"5vho" }, + { + "sim":103.0, + "partner":"5vhj" + }, { "sim":103.0, "partner":"5vhp" @@ -434704,15 +436626,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":100.0, @@ -434756,11 +436678,11 @@ }, { "sim":98.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":98.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":97.0, @@ -434812,11 +436734,11 @@ }, { "sim":95.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":95.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":95.0, @@ -434864,15 +436786,15 @@ }, { "sim":90.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":90.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":90.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":90.0, @@ -435026,14 +436948,6 @@ "sim":80.0, "partner":"1s70" }, - { - "sim":80.0, - "partner":"6m11" - }, - { - "sim":80.0, - "partner":"6m12" - }, { "sim":80.0, "partner":"6m13" @@ -435059,8 +436973,12 @@ "partner":"4o1p" }, { - "sim":79.0, - "partner":"6v9x" + "sim":80.0, + "partner":"6m11" + }, + { + "sim":80.0, + "partner":"6m12" }, { "sim":79.0, @@ -435074,6 +436992,10 @@ "sim":79.0, "partner":"6v9w" }, + { + "sim":79.0, + "partner":"6v9x" + }, { "sim":79.0, "partner":"6pqo" @@ -435092,19 +437014,19 @@ }, { "sim":78.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":78.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":78.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":78.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":78.0, @@ -435156,11 +437078,11 @@ }, { "sim":74.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":74.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":74.0, @@ -435234,10 +437156,6 @@ "sim":71.0, "partner":"5dne" }, - { - "sim":70.0, - "partner":"2a5e" - }, { "sim":70.0, "partner":"1dc2" @@ -435248,15 +437166,15 @@ }, { "sim":70.0, - "partner":"6mca" + "partner":"2a5e" }, { "sim":70.0, - "partner":"5wo6" + "partner":"6mca" }, { "sim":70.0, - "partner":"5iwr" + "partner":"5wo6" }, { "sim":70.0, @@ -435312,15 +437230,15 @@ }, { "sim":70.0, - "partner":"5wo7" + "partner":"5iwr" }, { - "sim":69.0, - "partner":"6if3" + "sim":70.0, + "partner":"5wo7" }, { "sim":69.0, - "partner":"6o1p" + "partner":"6if3" }, { "sim":69.0, @@ -435358,6 +437276,10 @@ "sim":69.0, "partner":"6dmw" }, + { + "sim":69.0, + "partner":"6o1p" + }, { "sim":68.0, "partner":"5cer" @@ -435378,10 +437300,6 @@ "sim":63.0, "partner":"8pef" }, - { - "sim":63.0, - "partner":"7k4a" - }, { "sim":63.0, "partner":"7k4b" @@ -435404,7 +437322,7 @@ }, { "sim":63.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":63.0, @@ -435420,11 +437338,11 @@ }, { "sim":63.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":63.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":63.0, @@ -435442,6 +437360,10 @@ "sim":63.0, "partner":"6bo8" }, + { + "sim":63.0, + "partner":"6bo9" + }, { "sim":62.0, "partner":"6ghm" @@ -435546,10 +437468,6 @@ "sim":51.0, "partner":"6uw4" }, - { - "sim":51.0, - "partner":"6mhw" - }, { "sim":51.0, "partner":"6mhx" @@ -435565,6 +437483,10 @@ { "sim":51.0, "partner":"6mhv" + }, + { + "sim":51.0, + "partner":"6mhw" } ], "struct_thr_sim_designed":[ @@ -435790,55 +437712,55 @@ ], "subtitle":"Cryo-em structure of designed protein nanoparticle tip60 (truncated icosahedral protein composed of 60-mer fusion proteins)", "tags":[ - "virus like particle", "de novo protein", - "artificial designed protein complex" + "artificial designed protein complex", + "virus like particle" ], "keywords":[ - "nanocages", - "sites", - "domain", "supramolecular", + "surface", + "interestingly", + "revealed", "many", - "pentameric", - "proteins", - "herein", - "solved", - "architecture", - "report", - "biochemical", + "development", + "nanoparticle", + "fusion", "nanoparticles", - "exterior", + "interior", + "domain", + "potential", + "structure", + "nanocages", + "report", + "herein", + "tip60", + "uniform", + "pentameric", + "recently", "surfaces", + "protein", + "modifiable", "useful", + "biochemical", + "20", + "proteins", + "sites", + "mutants", + "biomedical", "broad", - "icosahedral", - "dimeric", - "modifiable", - "potential", - "interestingly", - "nanoparticle", - "protein", - "uniform", - "using", "microscopy", + "architecture", + "exterior", + "solved", + "developed", "applications", - "pores", - "surface", "symmmetrically", - "structure", - "interior", - "development", - "tip60", - "revealed", - "biomedical", + "range", "future", - "fusion", - "recently", - "mutants", - "20", - "developed", - "range" + "icosahedral", + "using", + "pores", + "dimeric" ], "release_date":"2021-09-15", "publication":"\"Icosahedral 60-meric porous structure of designed supramolecular protein nanoparticle TIP60\", Chem.Commun.(Camb.), 57, 10226-10229", @@ -435985,52 +437907,52 @@ ], "subtitle":"Designed enzyme ra61 m48k\/i72d mutant: form i", "tags":[ - "mutation", - "retro-aldol reaction", + "aldol reaction", "de novo protein", + "mutation", "reaction direction", - "aldol reaction" + "retro-aldol reaction" ], "keywords":[ - "depending", - "reported", - "created", - "reversibly", - "results", + "reaction", + "often", + "efficient", "one", + "indicate", + "concentrations", + "reactions", + "natural", + "altered", + "previously", "efficiently", - "amino", - "report", - "catalysts", - "enzymes", - "aldol", "acid", - "efficient", - "less", - "reactions", - "generated", - "reaction", - "often", - "reactants", - "scaffold", + "report", + "aldolase", "replacing", - "catalyze", - "altered", + "catalyst", + "results", + "usually", + "directionality", "protein", - "levels", - "catalyzing", "derived", - "natural", - "directionality", + "depending", + "amino", + "products", "catalyzed", - "indicate", "varying", - "usually", - "catalyst", - "products", - "aldolase", - "previously", - "concentrations" + "enzymes", + "reversibly", + "scaffold", + "reported", + "levels", + "generated", + "created", + "aldol", + "less", + "catalyzing", + "reactants", + "catalysts", + "catalyze" ], "release_date":"2021-11-24", "publication":"\"Varying the Directionality of Protein Catalysts for Aldol and Retro-Aldol Reactions\", Chembiochem, 23, e202100435-e202100435", @@ -436063,19 +437985,19 @@ "seq_thr_sim_designed":[ { "sim":432.0, - "partner":"7f1j" + "partner":"7f1l" }, { "sim":432.0, - "partner":"7f1i" + "partner":"7f1j" }, { "sim":432.0, - "partner":"7f1k" + "partner":"7f1i" }, { "sim":432.0, - "partner":"7f1l" + "partner":"7f1k" } ], "seq_thr_sim_natural":[ @@ -436217,20 +438139,12 @@ }, { "sim":218.0, - "partner":"2b42" - }, - { - "sim":218.0, - "partner":"3hd8" + "partner":"5k9y" }, { "sim":218.0, "partner":"1c5i" }, - { - "sim":218.0, - "partner":"5k9y" - }, { "sim":218.0, "partner":"2z79" @@ -436259,6 +438173,14 @@ "sim":218.0, "partner":"1xnb" }, + { + "sim":218.0, + "partner":"3hd8" + }, + { + "sim":218.0, + "partner":"2b42" + }, { "sim":218.0, "partner":"1bvv" @@ -436307,10 +438229,6 @@ "sim":209.0, "partner":"6kwc" }, - { - "sim":208.0, - "partner":"6k9w" - }, { "sim":208.0, "partner":"2d97" @@ -436333,19 +438251,19 @@ }, { "sim":208.0, - "partner":"4xq4" + "partner":"6jwb" }, { "sim":208.0, - "partner":"6jwb" + "partner":"4xq4" }, { "sim":208.0, - "partner":"5zo0" + "partner":"6jxl" }, { "sim":208.0, - "partner":"6jxl" + "partner":"5zo0" }, { "sim":208.0, @@ -436357,23 +438275,23 @@ }, { "sim":208.0, - "partner":"5zh0" + "partner":"6k9r" }, { "sim":208.0, - "partner":"4hk8" + "partner":"5zh0" }, { "sim":208.0, - "partner":"6k9r" + "partner":"4hk8" }, { "sim":208.0, - "partner":"4xpv" + "partner":"6jug" }, { "sim":208.0, - "partner":"6jug" + "partner":"4xpv" }, { "sim":208.0, @@ -436385,11 +438303,7 @@ }, { "sim":208.0, - "partner":"6kw9" - }, - { - "sim":208.0, - "partner":"3lgr" + "partner":"6k9w" }, { "sim":208.0, @@ -436401,15 +438315,15 @@ }, { "sim":208.0, - "partner":"2dfc" + "partner":"6kwf" }, { "sim":208.0, - "partner":"3akp" + "partner":"2dfc" }, { "sim":208.0, - "partner":"6kwf" + "partner":"3akp" }, { "sim":208.0, @@ -436461,11 +438375,11 @@ }, { "sim":208.0, - "partner":"1enx" + "partner":"2jic" }, { "sim":208.0, - "partner":"2jic" + "partner":"1enx" }, { "sim":208.0, @@ -436475,25 +438389,29 @@ "sim":208.0, "partner":"1xyo" }, + { + "sim":208.0, + "partner":"6kvv" + }, { "sim":208.0, "partner":"1xyp" }, { "sim":208.0, - "partner":"6kvv" + "partner":"6kw9" }, { - "sim":207.0, - "partner":"6k9x" + "sim":208.0, + "partner":"3lgr" }, { "sim":207.0, - "partner":"5zkz" + "partner":"6kwe" }, { "sim":207.0, - "partner":"6kwe" + "partner":"5zkz" }, { "sim":207.0, @@ -436507,6 +438425,10 @@ "sim":207.0, "partner":"6jzp" }, + { + "sim":207.0, + "partner":"6k9x" + }, { "sim":207.0, "partner":"1igo" @@ -436609,11 +438531,11 @@ }, { "sim":132.0, - "partner":"1t6g" + "partner":"1bk1" }, { "sim":132.0, - "partner":"1bk1" + "partner":"1t6g" }, { "sim":132.0, @@ -436677,11 +438599,11 @@ }, { "sim":99.0, - "partner":"5gy8" + "partner":"5gye" }, { "sim":99.0, - "partner":"5gye" + "partner":"5gy8" }, { "sim":98.0, @@ -436766,7 +438688,7 @@ ], "seq_max_sim_designed":{ "sim":432.0, - "partner":"7f1j" + "partner":"7f1l" }, "seq_max_sim_natural":{ "sim":423.0, @@ -436853,52 +438775,52 @@ ], "subtitle":"Designed enzyme ra61 m48k\/i72d mutant: form ii", "tags":[ - "mutation", - "retro-aldol reaction", + "aldol reaction", "de novo protein", + "mutation", "reaction direction", - "aldol reaction" + "retro-aldol reaction" ], "keywords":[ - "depending", - "reported", - "created", - "reversibly", - "results", + "reaction", + "often", + "efficient", "one", + "indicate", + "concentrations", + "reactions", + "natural", + "altered", + "previously", "efficiently", - "amino", - "report", - "catalysts", - "enzymes", - "aldol", "acid", - "efficient", - "less", - "reactions", - "generated", - "reaction", - "often", - "reactants", - "scaffold", + "report", + "aldolase", "replacing", - "catalyze", - "altered", + "catalyst", + "results", + "usually", + "directionality", "protein", - "levels", - "catalyzing", "derived", - "natural", - "directionality", + "depending", + "amino", + "products", "catalyzed", - "indicate", "varying", - "usually", - "catalyst", - "products", - "aldolase", - "previously", - "concentrations" + "enzymes", + "reversibly", + "scaffold", + "reported", + "levels", + "generated", + "created", + "aldol", + "less", + "catalyzing", + "reactants", + "catalysts", + "catalyze" ], "release_date":"2021-11-24", "publication":"\"Varying the Directionality of Protein Catalysts for Aldol and Retro-Aldol Reactions\", Chembiochem, 23, e202100435-e202100435", @@ -436931,19 +438853,19 @@ "seq_thr_sim_designed":[ { "sim":432.0, - "partner":"7f1j" + "partner":"7f1l" }, { "sim":432.0, - "partner":"7f1h" + "partner":"7f1j" }, { "sim":432.0, - "partner":"7f1k" + "partner":"7f1h" }, { "sim":432.0, - "partner":"7f1l" + "partner":"7f1k" } ], "seq_thr_sim_natural":[ @@ -437085,20 +439007,12 @@ }, { "sim":218.0, - "partner":"2b42" - }, - { - "sim":218.0, - "partner":"3hd8" + "partner":"5k9y" }, { "sim":218.0, "partner":"1c5i" }, - { - "sim":218.0, - "partner":"5k9y" - }, { "sim":218.0, "partner":"2z79" @@ -437127,6 +439041,14 @@ "sim":218.0, "partner":"1xnb" }, + { + "sim":218.0, + "partner":"3hd8" + }, + { + "sim":218.0, + "partner":"2b42" + }, { "sim":218.0, "partner":"1bvv" @@ -437175,10 +439097,6 @@ "sim":209.0, "partner":"6kwc" }, - { - "sim":208.0, - "partner":"6k9w" - }, { "sim":208.0, "partner":"2d97" @@ -437201,19 +439119,19 @@ }, { "sim":208.0, - "partner":"4xq4" + "partner":"6jwb" }, { "sim":208.0, - "partner":"6jwb" + "partner":"4xq4" }, { "sim":208.0, - "partner":"5zo0" + "partner":"6jxl" }, { "sim":208.0, - "partner":"6jxl" + "partner":"5zo0" }, { "sim":208.0, @@ -437225,23 +439143,23 @@ }, { "sim":208.0, - "partner":"5zh0" + "partner":"6k9r" }, { "sim":208.0, - "partner":"4hk8" + "partner":"5zh0" }, { "sim":208.0, - "partner":"6k9r" + "partner":"4hk8" }, { "sim":208.0, - "partner":"4xpv" + "partner":"6jug" }, { "sim":208.0, - "partner":"6jug" + "partner":"4xpv" }, { "sim":208.0, @@ -437253,11 +439171,7 @@ }, { "sim":208.0, - "partner":"6kw9" - }, - { - "sim":208.0, - "partner":"3lgr" + "partner":"6k9w" }, { "sim":208.0, @@ -437269,15 +439183,15 @@ }, { "sim":208.0, - "partner":"2dfc" + "partner":"6kwf" }, { "sim":208.0, - "partner":"3akp" + "partner":"2dfc" }, { "sim":208.0, - "partner":"6kwf" + "partner":"3akp" }, { "sim":208.0, @@ -437329,11 +439243,11 @@ }, { "sim":208.0, - "partner":"1enx" + "partner":"2jic" }, { "sim":208.0, - "partner":"2jic" + "partner":"1enx" }, { "sim":208.0, @@ -437343,25 +439257,29 @@ "sim":208.0, "partner":"1xyo" }, + { + "sim":208.0, + "partner":"6kvv" + }, { "sim":208.0, "partner":"1xyp" }, { "sim":208.0, - "partner":"6kvv" + "partner":"6kw9" }, { - "sim":207.0, - "partner":"6k9x" + "sim":208.0, + "partner":"3lgr" }, { "sim":207.0, - "partner":"5zkz" + "partner":"6kwe" }, { "sim":207.0, - "partner":"6kwe" + "partner":"5zkz" }, { "sim":207.0, @@ -437375,6 +439293,10 @@ "sim":207.0, "partner":"6jzp" }, + { + "sim":207.0, + "partner":"6k9x" + }, { "sim":207.0, "partner":"1igo" @@ -437477,11 +439399,11 @@ }, { "sim":132.0, - "partner":"1t6g" + "partner":"1bk1" }, { "sim":132.0, - "partner":"1bk1" + "partner":"1t6g" }, { "sim":132.0, @@ -437545,11 +439467,11 @@ }, { "sim":99.0, - "partner":"5gy8" + "partner":"5gye" }, { "sim":99.0, - "partner":"5gye" + "partner":"5gy8" }, { "sim":98.0, @@ -437630,7 +439552,7 @@ ], "seq_max_sim_designed":{ "sim":432.0, - "partner":"7f1j" + "partner":"7f1l" }, "seq_max_sim_natural":{ "sim":423.0, @@ -437717,52 +439639,52 @@ ], "subtitle":"Designed enzyme ra61 m48k\/i72d mutant: form iii", "tags":[ - "mutation", - "retro-aldol reaction", + "aldol reaction", "de novo protein", + "mutation", "reaction direction", - "aldol reaction" + "retro-aldol reaction" ], "keywords":[ - "depending", - "reported", - "created", - "reversibly", - "results", + "reaction", + "often", + "efficient", "one", + "indicate", + "concentrations", + "reactions", + "natural", + "altered", + "previously", "efficiently", - "amino", - "report", - "catalysts", - "enzymes", - "aldol", "acid", - "efficient", - "less", - "reactions", - "generated", - "reaction", - "often", - "reactants", - "scaffold", + "report", + "aldolase", "replacing", - "catalyze", - "altered", + "catalyst", + "results", + "usually", + "directionality", "protein", - "levels", - "catalyzing", "derived", - "natural", - "directionality", + "depending", + "amino", + "products", "catalyzed", - "indicate", "varying", - "usually", - "catalyst", - "products", - "aldolase", - "previously", - "concentrations" + "enzymes", + "reversibly", + "scaffold", + "reported", + "levels", + "generated", + "created", + "aldol", + "less", + "catalyzing", + "reactants", + "catalysts", + "catalyze" ], "release_date":"2021-11-24", "publication":"\"Varying the Directionality of Protein Catalysts for Aldol and Retro-Aldol Reactions\", Chembiochem, 23, e202100435-e202100435", @@ -437795,7 +439717,7 @@ "seq_thr_sim_designed":[ { "sim":432.0, - "partner":"7f1i" + "partner":"7f1l" }, { "sim":432.0, @@ -437803,11 +439725,11 @@ }, { "sim":432.0, - "partner":"7f1k" + "partner":"7f1i" }, { "sim":432.0, - "partner":"7f1l" + "partner":"7f1k" } ], "seq_thr_sim_natural":[ @@ -437949,20 +439871,12 @@ }, { "sim":218.0, - "partner":"2b42" - }, - { - "sim":218.0, - "partner":"3hd8" + "partner":"5k9y" }, { "sim":218.0, "partner":"1c5i" }, - { - "sim":218.0, - "partner":"5k9y" - }, { "sim":218.0, "partner":"2z79" @@ -437991,6 +439905,14 @@ "sim":218.0, "partner":"1xnb" }, + { + "sim":218.0, + "partner":"3hd8" + }, + { + "sim":218.0, + "partner":"2b42" + }, { "sim":218.0, "partner":"1bvv" @@ -438039,10 +439961,6 @@ "sim":209.0, "partner":"6kwc" }, - { - "sim":208.0, - "partner":"6k9w" - }, { "sim":208.0, "partner":"2d97" @@ -438065,19 +439983,19 @@ }, { "sim":208.0, - "partner":"4xq4" + "partner":"6jwb" }, { "sim":208.0, - "partner":"6jwb" + "partner":"4xq4" }, { "sim":208.0, - "partner":"5zo0" + "partner":"6jxl" }, { "sim":208.0, - "partner":"6jxl" + "partner":"5zo0" }, { "sim":208.0, @@ -438089,23 +440007,23 @@ }, { "sim":208.0, - "partner":"5zh0" + "partner":"6k9r" }, { "sim":208.0, - "partner":"4hk8" + "partner":"5zh0" }, { "sim":208.0, - "partner":"6k9r" + "partner":"4hk8" }, { "sim":208.0, - "partner":"4xpv" + "partner":"6jug" }, { "sim":208.0, - "partner":"6jug" + "partner":"4xpv" }, { "sim":208.0, @@ -438117,11 +440035,7 @@ }, { "sim":208.0, - "partner":"6kw9" - }, - { - "sim":208.0, - "partner":"3lgr" + "partner":"6k9w" }, { "sim":208.0, @@ -438133,15 +440047,15 @@ }, { "sim":208.0, - "partner":"2dfc" + "partner":"6kwf" }, { "sim":208.0, - "partner":"3akp" + "partner":"2dfc" }, { "sim":208.0, - "partner":"6kwf" + "partner":"3akp" }, { "sim":208.0, @@ -438193,11 +440107,11 @@ }, { "sim":208.0, - "partner":"1enx" + "partner":"2jic" }, { "sim":208.0, - "partner":"2jic" + "partner":"1enx" }, { "sim":208.0, @@ -438207,25 +440121,29 @@ "sim":208.0, "partner":"1xyo" }, + { + "sim":208.0, + "partner":"6kvv" + }, { "sim":208.0, "partner":"1xyp" }, { "sim":208.0, - "partner":"6kvv" + "partner":"6kw9" }, { - "sim":207.0, - "partner":"6k9x" + "sim":208.0, + "partner":"3lgr" }, { "sim":207.0, - "partner":"5zkz" + "partner":"6kwe" }, { "sim":207.0, - "partner":"6kwe" + "partner":"5zkz" }, { "sim":207.0, @@ -438239,6 +440157,10 @@ "sim":207.0, "partner":"6jzp" }, + { + "sim":207.0, + "partner":"6k9x" + }, { "sim":207.0, "partner":"1igo" @@ -438341,11 +440263,11 @@ }, { "sim":132.0, - "partner":"1t6g" + "partner":"1bk1" }, { "sim":132.0, - "partner":"1bk1" + "partner":"1t6g" }, { "sim":132.0, @@ -438409,11 +440331,11 @@ }, { "sim":99.0, - "partner":"5gy8" + "partner":"5gye" }, { "sim":99.0, - "partner":"5gye" + "partner":"5gy8" }, { "sim":98.0, @@ -438498,7 +440420,7 @@ ], "seq_max_sim_designed":{ "sim":432.0, - "partner":"7f1i" + "partner":"7f1l" }, "seq_max_sim_natural":{ "sim":423.0, @@ -438585,52 +440507,52 @@ ], "subtitle":"Designed enzyme ra61 m48k\/i72d mutant: form iv", "tags":[ - "mutation", - "retro-aldol reaction", + "aldol reaction", "de novo protein", + "mutation", "reaction direction", - "aldol reaction" + "retro-aldol reaction" ], "keywords":[ - "depending", - "reported", - "created", - "reversibly", - "results", + "reaction", + "often", + "efficient", "one", + "indicate", + "concentrations", + "reactions", + "natural", + "altered", + "previously", "efficiently", - "amino", - "report", - "catalysts", - "enzymes", - "aldol", "acid", - "efficient", - "less", - "reactions", - "generated", - "reaction", - "often", - "reactants", - "scaffold", + "report", + "aldolase", "replacing", - "catalyze", - "altered", + "catalyst", + "results", + "usually", + "directionality", "protein", - "levels", - "catalyzing", "derived", - "natural", - "directionality", + "depending", + "amino", + "products", "catalyzed", - "indicate", "varying", - "usually", - "catalyst", - "products", - "aldolase", - "previously", - "concentrations" + "enzymes", + "reversibly", + "scaffold", + "reported", + "levels", + "generated", + "created", + "aldol", + "less", + "catalyzing", + "reactants", + "catalysts", + "catalyze" ], "release_date":"2021-11-24", "publication":"\"Varying the Directionality of Protein Catalysts for Aldol and Retro-Aldol Reactions\", Chembiochem, 23, e202100435-e202100435", @@ -438663,11 +440585,11 @@ "seq_thr_sim_designed":[ { "sim":432.0, - "partner":"7f1j" + "partner":"7f1l" }, { "sim":432.0, - "partner":"7f1i" + "partner":"7f1j" }, { "sim":432.0, @@ -438675,7 +440597,7 @@ }, { "sim":432.0, - "partner":"7f1l" + "partner":"7f1i" } ], "seq_thr_sim_natural":[ @@ -438817,20 +440739,12 @@ }, { "sim":218.0, - "partner":"2b42" - }, - { - "sim":218.0, - "partner":"3hd8" + "partner":"5k9y" }, { "sim":218.0, "partner":"1c5i" }, - { - "sim":218.0, - "partner":"5k9y" - }, { "sim":218.0, "partner":"2z79" @@ -438859,6 +440773,14 @@ "sim":218.0, "partner":"1xnb" }, + { + "sim":218.0, + "partner":"3hd8" + }, + { + "sim":218.0, + "partner":"2b42" + }, { "sim":218.0, "partner":"1bvv" @@ -438907,10 +440829,6 @@ "sim":209.0, "partner":"6kwc" }, - { - "sim":208.0, - "partner":"6k9w" - }, { "sim":208.0, "partner":"2d97" @@ -438933,19 +440851,19 @@ }, { "sim":208.0, - "partner":"4xq4" + "partner":"6jwb" }, { "sim":208.0, - "partner":"6jwb" + "partner":"4xq4" }, { "sim":208.0, - "partner":"5zo0" + "partner":"6jxl" }, { "sim":208.0, - "partner":"6jxl" + "partner":"5zo0" }, { "sim":208.0, @@ -438957,23 +440875,23 @@ }, { "sim":208.0, - "partner":"5zh0" + "partner":"6k9r" }, { "sim":208.0, - "partner":"4hk8" + "partner":"5zh0" }, { "sim":208.0, - "partner":"6k9r" + "partner":"4hk8" }, { "sim":208.0, - "partner":"4xpv" + "partner":"6jug" }, { "sim":208.0, - "partner":"6jug" + "partner":"4xpv" }, { "sim":208.0, @@ -438985,11 +440903,7 @@ }, { "sim":208.0, - "partner":"6kw9" - }, - { - "sim":208.0, - "partner":"3lgr" + "partner":"6k9w" }, { "sim":208.0, @@ -439001,15 +440915,15 @@ }, { "sim":208.0, - "partner":"2dfc" + "partner":"6kwf" }, { "sim":208.0, - "partner":"3akp" + "partner":"2dfc" }, { "sim":208.0, - "partner":"6kwf" + "partner":"3akp" }, { "sim":208.0, @@ -439061,11 +440975,11 @@ }, { "sim":208.0, - "partner":"1enx" + "partner":"2jic" }, { "sim":208.0, - "partner":"2jic" + "partner":"1enx" }, { "sim":208.0, @@ -439075,25 +440989,29 @@ "sim":208.0, "partner":"1xyo" }, + { + "sim":208.0, + "partner":"6kvv" + }, { "sim":208.0, "partner":"1xyp" }, { "sim":208.0, - "partner":"6kvv" + "partner":"6kw9" }, { - "sim":207.0, - "partner":"6k9x" + "sim":208.0, + "partner":"3lgr" }, { "sim":207.0, - "partner":"5zkz" + "partner":"6kwe" }, { "sim":207.0, - "partner":"6kwe" + "partner":"5zkz" }, { "sim":207.0, @@ -439107,6 +441025,10 @@ "sim":207.0, "partner":"6jzp" }, + { + "sim":207.0, + "partner":"6k9x" + }, { "sim":207.0, "partner":"1igo" @@ -439209,11 +441131,11 @@ }, { "sim":132.0, - "partner":"1t6g" + "partner":"1bk1" }, { "sim":132.0, - "partner":"1bk1" + "partner":"1t6g" }, { "sim":132.0, @@ -439277,11 +441199,11 @@ }, { "sim":99.0, - "partner":"5gy8" + "partner":"5gye" }, { "sim":99.0, - "partner":"5gye" + "partner":"5gy8" }, { "sim":98.0, @@ -439358,7 +441280,7 @@ ], "seq_max_sim_designed":{ "sim":432.0, - "partner":"7f1j" + "partner":"7f1l" }, "seq_max_sim_natural":{ "sim":423.0, @@ -439445,52 +441367,52 @@ ], "subtitle":"Designed enzyme ra61 m48k\/i72d mutant: form v", "tags":[ - "mutation", - "retro-aldol reaction", + "aldol reaction", "de novo protein", + "mutation", "reaction direction", - "aldol reaction" + "retro-aldol reaction" ], "keywords":[ - "depending", - "reported", - "created", - "reversibly", - "results", + "reaction", + "often", + "efficient", "one", + "indicate", + "concentrations", + "reactions", + "natural", + "altered", + "previously", "efficiently", - "amino", - "report", - "catalysts", - "enzymes", - "aldol", "acid", - "efficient", - "less", - "reactions", - "generated", - "reaction", - "often", - "reactants", - "scaffold", + "report", + "aldolase", "replacing", - "catalyze", - "altered", + "catalyst", + "results", + "usually", + "directionality", "protein", - "levels", - "catalyzing", "derived", - "natural", - "directionality", + "depending", + "amino", + "products", "catalyzed", - "indicate", "varying", - "usually", - "catalyst", - "products", - "aldolase", - "previously", - "concentrations" + "enzymes", + "reversibly", + "scaffold", + "reported", + "levels", + "generated", + "created", + "aldol", + "less", + "catalyzing", + "reactants", + "catalysts", + "catalyze" ], "release_date":"2021-11-24", "publication":"\"Varying the Directionality of Protein Catalysts for Aldol and Retro-Aldol Reactions\", Chembiochem, 23, e202100435-e202100435", @@ -439527,11 +441449,11 @@ }, { "sim":432.0, - "partner":"7f1i" + "partner":"7f1h" }, { "sim":432.0, - "partner":"7f1h" + "partner":"7f1i" }, { "sim":432.0, @@ -439677,20 +441599,12 @@ }, { "sim":218.0, - "partner":"2b42" - }, - { - "sim":218.0, - "partner":"3hd8" + "partner":"5k9y" }, { "sim":218.0, "partner":"1c5i" }, - { - "sim":218.0, - "partner":"5k9y" - }, { "sim":218.0, "partner":"2z79" @@ -439719,6 +441633,14 @@ "sim":218.0, "partner":"1xnb" }, + { + "sim":218.0, + "partner":"3hd8" + }, + { + "sim":218.0, + "partner":"2b42" + }, { "sim":218.0, "partner":"1bvv" @@ -439767,10 +441689,6 @@ "sim":209.0, "partner":"6kwc" }, - { - "sim":208.0, - "partner":"6k9w" - }, { "sim":208.0, "partner":"2d97" @@ -439793,19 +441711,19 @@ }, { "sim":208.0, - "partner":"4xq4" + "partner":"6jwb" }, { "sim":208.0, - "partner":"6jwb" + "partner":"4xq4" }, { "sim":208.0, - "partner":"5zo0" + "partner":"6jxl" }, { "sim":208.0, - "partner":"6jxl" + "partner":"5zo0" }, { "sim":208.0, @@ -439817,23 +441735,23 @@ }, { "sim":208.0, - "partner":"5zh0" + "partner":"6k9r" }, { "sim":208.0, - "partner":"4hk8" + "partner":"5zh0" }, { "sim":208.0, - "partner":"6k9r" + "partner":"4hk8" }, { "sim":208.0, - "partner":"4xpv" + "partner":"6jug" }, { "sim":208.0, - "partner":"6jug" + "partner":"4xpv" }, { "sim":208.0, @@ -439845,11 +441763,7 @@ }, { "sim":208.0, - "partner":"6kw9" - }, - { - "sim":208.0, - "partner":"3lgr" + "partner":"6k9w" }, { "sim":208.0, @@ -439861,15 +441775,15 @@ }, { "sim":208.0, - "partner":"2dfc" + "partner":"6kwf" }, { "sim":208.0, - "partner":"3akp" + "partner":"2dfc" }, { "sim":208.0, - "partner":"6kwf" + "partner":"3akp" }, { "sim":208.0, @@ -439921,11 +441835,11 @@ }, { "sim":208.0, - "partner":"1enx" + "partner":"2jic" }, { "sim":208.0, - "partner":"2jic" + "partner":"1enx" }, { "sim":208.0, @@ -439935,25 +441849,29 @@ "sim":208.0, "partner":"1xyo" }, + { + "sim":208.0, + "partner":"6kvv" + }, { "sim":208.0, "partner":"1xyp" }, { "sim":208.0, - "partner":"6kvv" + "partner":"6kw9" }, { - "sim":207.0, - "partner":"6k9x" + "sim":208.0, + "partner":"3lgr" }, { "sim":207.0, - "partner":"5zkz" + "partner":"6kwe" }, { "sim":207.0, - "partner":"6kwe" + "partner":"5zkz" }, { "sim":207.0, @@ -439967,6 +441885,10 @@ "sim":207.0, "partner":"6jzp" }, + { + "sim":207.0, + "partner":"6k9x" + }, { "sim":207.0, "partner":"1igo" @@ -440069,11 +441991,11 @@ }, { "sim":132.0, - "partner":"1t6g" + "partner":"1bk1" }, { "sim":132.0, - "partner":"1bk1" + "partner":"1t6g" }, { "sim":132.0, @@ -440137,11 +442059,11 @@ }, { "sim":99.0, - "partner":"5gy8" + "partner":"5gye" }, { "sim":99.0, - "partner":"5gye" + "partner":"5gy8" }, { "sim":98.0, @@ -440285,102 +442207,102 @@ "subtitle":"Top7 surface mutant k42a q43a k46a k57s k58s, and i68r", "tags":[ "de novo protein", - "surface mutant", - "top7" + "top7", + "surface mutant" ], "keywords":[ - "diffracted", - "finalize", - "consecutive", - "initially", - "thus", - "architecture", + "pure", + "engineering", + "whose", + "resolution", + "direction", + "around", "intermolecular", - "use", + "free", "acid", - "determination", - "designed", - "mutations", + "new", + "residue", + "finalize", + "aligned", + "finalized", + "model", + "protein", + "terminal", + "showed", + "novo", "top7", - "improved", + "applications", "crystal", - "disrupt", - "shared", - "interactions", - "diffraction", - "structure", - "intended", - "attempted", - "de", - "although", + "weak", + "mutated", + "initially", "tag", - "\u00e5", - "crystallized", + "formed", + "determination", + "hexahistidine", + "due", + "r", + "thus", + "although", "decided", - "resulting", + "intended", + "makes", + "useful", + "mutants", + "packing", + "use", + "architecture", + "scaffold", "interface", - "easily", - "nature", - "lacked", - "direction", - "whose", - "structures", - "r", + "found", + "mutant", "construct", - "showed", - "suitable", - "mutants", - "form", - "contributed", - "free", + "studying", "facilitate", - "makes", - "data", - "amino", - "trace", - "common", - "resolution", - "identify", - "mutant", - "aligned", - "useful", "top7sm2", - "engineering", - "model", - "weak", - "introduce", - "applications", - "finalized", - "surface", - "high", - "sequence", + "values", "property", + "surface", + "expecting", + "convenient", + "crystallized", + "diffracted", + "easily", + "amino", + "improved", "origin", - "could", "formation", - "around", - "packing", - "hexahistidine", - "despite", + "sequence", + "common", + "crystals", + "top7sm1", + "lacked", + "shared", + "could", + "designed", + "form", + "consecutive", + "diffraction", "one", - "values", - "novo", - "convenient", + "mutations", + "structures", + "de", + "suitable", + "attempted", + "\u00e5", + "structure", + "introduce", + "resulting", "evolutional", - "found", - "due", - "studying", - "expecting", - "scaffold", - "protein", - "residue", - "mutated", - "terminal", - "pure", - "top7sm1", - "formed", - "crystals", - "new" + "interactions", + "nature", + "identify", + "contributed", + "high", + "trace", + "disrupt", + "despite", + "data" ], "release_date":"2022-05-18", "publication":"\"Surface Engineering of Top7 to Facilitate Structure Determination\", Int J Mol Sci, 23", @@ -440535,78 +442457,78 @@ ], "subtitle":"Co-lockr: de novo designed protein switch", "tags":[ - "de novo protein", "helical bundle", + "de novo protein", "protein switch" ], "keywords":[ - "rapid", + "designed", + "surface", + "complex", + "operations", + "activate", + "mammalian", "responses", - "generating", - "computations", - "logic", - "change", - "proteins", - "conditions", - "thus", + "recognition", + "challenging", + "design", "conformational", "specificity", - "cell", - "lack", - "antigens", + "resolution", "avoiding", - "study", + "marker", "de", - "antigen", "single", - "resolution", - "novo", - "populations", - "designed", + "include", "multiple", - "challenging", - "perform", - "would", - "boolean", - "surfaces", - "integrating", - "redirect", - "recognition", - "two", + "combinations", + "thus", + "targeting", + "distinguishes", "specific", + "within", + "antigens", "add", + "antigen", + "third", + "expressing", + "surfaces", "target", - "include", - "marker", - "design", - "avoid", - "protein", - "precise", - "mammalian", - "using", - "present", - "switches", - "met", - "complex", - "gates", + "computations", "interactions", - "surface", + "protein", + "cell", + "study", + "populations", + "proteins", + "would", + "binding", "solution", - "tumor", - "third", + "rapid", + "integrating", + "met", + "logic", + "conditions", "output", - "types", - "within", - "distinct", - "distinguishes", - "operations", + "change", + "novo", + "tumor", "cells", - "combinations", - "binding", + "redirect", + "types", + "boolean", "implement", - "expressing", - "targeting", - "activate" + "distinct", + "perform", + "two", + "generating", + "present", + "precise", + "avoid", + "gates", + "using", + "switches", + "lack" ], "release_date":"2020-09-02", "publication":"\"Designed protein logic to target cells with precise combinations of surface antigens\", Science, 369, 1637-1643", @@ -440747,116 +442669,116 @@ ], "subtitle":"De novo designed two-domain di-zn(ii) and porphyrin-binding protein", "tags":[ - "de novo protein design", "metalloprotein", - "inter-domain coupling and cooperation", - "de novo protein", + "synthetic porphyrin", "allostery", - "synthetic porphyrin" + "de novo protein design", + "de novo protein", + "inter-domain coupling and cooperation" ], "keywords":[ - "domain", - "tighter", - "studies", - "coupling", - "reconstituted", - "appropriately", - "porphyrin", - "catalyzes", + "rate", + "fourfold", + "acts", + "modulated", "regulated", - "cat", - "dfp1", - "allosterically", + "parameters", "cofactors", - "crystal", - "based", - "next", - "acts", - "discover", - "synthetic", - "df", - "affected", - "designing", - "structure", - "establish", + "protein", + "helical", "italian", - "achieve", - "k", - "architectures", - "original", - "excellent", - "znp", - "proteins", - "de", - "family", - "\u00e5", - "connections", - "manner", - "strongly", - "influence", - "resulting", - "feasibility", - "binds", + "binding", + "changes", + "dfp1", "fully", - "fourfold", - "ferri", - "dynamics", - "center", + "next", + "phenol", "showed", - "tightly", - "dimetal", + "novo", + "manner", + "domains", + "expected", + "original", + "catalytic", + "two", + "crystal", + "k", + "establish", "english", - "phenol", - "designable", - "coupled", - "second", - "ps1", + "binds", + "connections", + "using", + "achieve", + "reaction", + "cat", + "bundles", + "due", + "agreement", + "cleft", + "allosterically", "oxidase", - "expected", + "influence", + "comprises", + "family", + "fused", "connected", - "linkers", - "bundles", - "changes", - "catalytic", + "designable", + "strongly", + "tightly", + "bound", + "proteins", + "capable", + "coupling", + "center", + "entirely", + "tight", "four", - "method", - "fused", - "agreement", - "diiron", - "induces", - "rate", + "introduced", + "computational", "bundle", + "tighter", + "ps1", "12", - "introduced", + "designing", "design", - "spanning", - "helical", - "modulated", - "using", - "scratch", - "describe", - "sequence", - "parameters", - "decrease", - "one", - "entirely", + "domain", "also", - "novo", - "cofactor", - "tight", - "cleft", - "reaction", - "capable", - "two", - "due", - "comprises", + "architectures", "leading", - "domains", - "protein", - "bound", + "feasibility", + "sequence", + "znp", + "reconstituted", + "excellent", + "df", + "describe", + "cofactor", + "method", + "scratch", + "dynamics", + "catalyzes", + "diiron", + "coupled", + "one", + "de", + "based", + "\u00e5", + "structure", + "synthetic", + "discover", + "resulting", + "affected", + "spanning", + "linkers", + "ferri", + "dimetal", "distinct", - "computational", - "binding" + "studies", + "appropriately", + "porphyrin", + "decrease", + "second", + "induces" ], "release_date":"2020-12-09", "publication":"\"Allosteric cooperation in a de novo-designed two-domain protein\", Proc.Natl.Acad.Sci.USA, 117, 33246-33253", @@ -440893,7 +442815,7 @@ }, { "sim":79.0, - "partner":"8d9o" + "partner":"5vjs" }, { "sim":79.0, @@ -440901,11 +442823,11 @@ }, { "sim":79.0, - "partner":"8d9p" + "partner":"8d9o" }, { "sim":79.0, - "partner":"5vjs" + "partner":"8d9p" }, { "sim":74.0, @@ -441049,107 +442971,107 @@ ], "subtitle":"Sars-cov-2 spike in complex with lcb1 (2rbds open)", "tags":[ - "covid-19", - "spike glycoprotein", - "seattle structural genomics center for infectious disease", - "inhibitor", - "viral protein", - "structural genomics", "neutralizing antibodies", + "seattle structural genomics center for infectious disease", "fusion protein", + "spike glycoprotein", + "viral protein", + "covid-19", + "ssgcid", "sars-cov-2", - "ssgcid" + "inhibitor", + "structural genomics" ], "keywords":[ - "domain", - "respiratory", - "modes", - "concentration", - "potent", - "strategy", "trimer", - "scaffolds", + "ic", + "hyperstable", + "ace2", + "minibinders", + "around", + "three", + "points", "acid", - "interacts", - "designed", - "receptor", + "new", + "strategy", + "folding", + "protein", + "milliliter", + "binding", "syndrome", - "provide", - "target", - "sequences", - "ic", - "optimize", - "inhibitors", - "therapeutic", + "microscopy", + "rbds", + "novo", + "cells", + "coronavirus", + "two", + "10", + "100", + "using", + "receptor", + "either", + "complex", + "rbd", + "nearly", "starting", - "interaction", - "built", - "acute", + "modes", + "infection", + "50", + "helix", + "stability", + "bound", "proteins", - "models", - "ace2", - "de", + "blocked", + "concentration", + "2", "enzyme", - "e6", - "picomolar", + "spike", + "nanograms", "nanomolar", - "structures", + "24", + "computational", + "35", + "values", + "inhibitory", + "median", + "design", + "ten", "therapeutics", - "three", - "either", - "nearly", + "acute", + "domain", "targeting", - "stability", - "35", - "100", - "per", - "minibinders", + "therapeutic", "amino", - "blocked", - "ranging", - "rbds", + "interaction", + "promising", + "interacts", + "identical", + "docked", + "e6", + "ectodomain", + "per", + "optimize", + "designed", "vero", - "identify", - "10", + "models", + "sequences", + "built", + "de", + "ranging", + "structures", "approaches", - "median", - "infection", - "spike", - "rbd", - "points", - "design", - "nanograms", - "using", - "promising", "severe", - "cells", - "inhibitory", - "around", - "designs", - "coronavirus", - "ectodomain", - "values", - "novo", + "respiratory", + "scaffolds", + "provide", + "target", + "inhibitors", + "identify", + "picomolar", + "potent", "human", - "affinities", - "two", - "50", - "milliliter", - "new", - "24", - "protein", - "bound", - "microscopy", - "2", - "complex", - "identical", - "helix", - "docked", - "hyperstable", - "computational", - "folding", - "binding", - "ten" + "designs", + "affinities" ], "release_date":"2020-09-23", "publication":"\"De novo design of picomolar SARS-CoV-2 miniprotein inhibitors\", Science, 370, 426-431", @@ -441186,6 +443108,50 @@ { "sim":110.0, "partner":"7jzu" + }, + { + "sim":74.0, + "partner":"8ydp" + }, + { + "sim":73.0, + "partner":"8ydt" + }, + { + "sim":72.0, + "partner":"8yds" + }, + { + "sim":72.0, + "partner":"8ydr" + }, + { + "sim":64.0, + "partner":"8ydu" + }, + { + "sim":64.0, + "partner":"8ydv" + }, + { + "sim":64.0, + "partner":"8ydw" + }, + { + "sim":64.0, + "partner":"8ydx" + }, + { + "sim":64.0, + "partner":"8ydy" + }, + { + "sim":64.0, + "partner":"8ydq" + }, + { + "sim":64.0, + "partner":"8ydz" } ], "struct_thr_sim_designed":[ @@ -441298,112 +443264,112 @@ ], "subtitle":"Crystal structure of deep network hallucinated protein 0217", "tags":[ - "de novo protein", "helical bundle", + "de novo protein", "machine learning" ], "keywords":[ - "alongside", - "background", - "distributions", - "129", - "thus", - "hallucinated", + "whether", "divergence", - "acid", - "crystallography", - "expressed", - "prediction", - "purified", - "methods", - "determined", - "sampling", - "sequences", - "synthetic", - "structure", + "genes", "escherichia", - "networks", - "trrosetta", - "predict", - "rich", - "novel", - "starting", - "consistent", + "unrelated", + "distance", + "methods", + "background", + "quite", + "inverted", + "information", + "three", + "points", + "acid", + "new", + "spectra", + "protein", "network", - "proteins", - "models", - "random", - "training", - "de", - "whether", - "carlo", + "maps", + "monte", + "neural", + "networks", + "novo", + "encoding", + "circular", "trained", - "yielded", - "used", + "expected", "27", + "two", + "purified", + "recent", + "using", + "captured", "occurring", + "deep", + "monodisperse", + "distributions", + "starting", + "thus", + "consistent", + "functions", + "input", + "matched", + "optimization", "folded", - "structures", - "naturally", - "three", - "native", - "circular", - "contribute", + "proteins", + "129", + "alongside", + "predict", + "sufficiently", "investigate", "obtained", - "considerable", - "expected", + "design", + "sampling", + "used", + "different", + "species", + "rich", + "prediction", + "carry", "amino", - "spectra", - "sufficiently", - "coli", - "generate", + "wide", + "trrosetta", "resulted", - "optimization", - "information", - "monte", - "functions", - "closely", - "points", - "spanning", - "design", - "distance", - "quite", - "using", - "progress", - "nmr", - "captured", - "recent", - "neural", - "maps", + "contrast", + "coli", + "predicted", "sequence", - "genes", - "featureless", - "input", - "optimizing", "range", - "predicted", - "averaged", - "encoding", + "hallucinated", + "models", + "naturally", + "sequences", + "space", "one", - "monodisperse", - "wide", - "novo", - "contrast", - "matched", - "carry", - "species", - "different", - "unrelated", - "two", - "inverted", - "protein", "distances", - "space", - "deep", - "dichroism", + "structures", "traditional", - "new" + "de", + "progress", + "training", + "expressed", + "contribute", + "structure", + "optimizing", + "synthetic", + "determined", + "closely", + "crystallography", + "nmr", + "spanning", + "random", + "yielded", + "considerable", + "native", + "dichroism", + "averaged", + "featureless", + "generate", + "novel", + "carlo" ], "release_date":"2021-12-22", "publication":"\"De novo protein design by deep network hallucination\", Nature, 600, 547-552", @@ -441476,14 +443442,6 @@ "sim":58.0, "partner":"6cl4" }, - { - "sim":58.0, - "partner":"5gg5" - }, - { - "sim":58.0, - "partner":"5xd1" - }, { "sim":58.0, "partner":"5gg6" @@ -441498,27 +443456,27 @@ }, { "sim":58.0, - "partner":"5gg7" + "partner":"6m6y" }, { "sim":58.0, - "partner":"5xd4" + "partner":"5gg7" }, { "sim":58.0, - "partner":"5xd5" + "partner":"5xd4" }, { "sim":58.0, - "partner":"6m6y" + "partner":"6m65" }, { "sim":58.0, - "partner":"5gg8" + "partner":"5xd5" }, { "sim":58.0, - "partner":"6m65" + "partner":"5gg8" }, { "sim":58.0, @@ -441548,6 +443506,14 @@ "sim":58.0, "partner":"6m69" }, + { + "sim":58.0, + "partner":"5gg5" + }, + { + "sim":58.0, + "partner":"5xd1" + }, { "sim":58.0, "partner":"6gnf" @@ -441584,17 +443550,13 @@ "sim":56.0, "partner":"6vsx" }, - { - "sim":56.0, - "partner":"5h5a" - }, { "sim":56.0, "partner":"5h54" }, { "sim":56.0, - "partner":"5zm4" + "partner":"5h5a" }, { "sim":56.0, @@ -441604,6 +443566,10 @@ "sim":56.0, "partner":"5zm3" }, + { + "sim":56.0, + "partner":"5zm4" + }, { "sim":56.0, "partner":"5h55" @@ -441614,11 +443580,11 @@ }, { "sim":55.0, - "partner":"5ho3" + "partner":"5ho1" }, { "sim":55.0, - "partner":"5ho1" + "partner":"5ho3" }, { "sim":55.0, @@ -441652,10 +443618,6 @@ "sim":55.0, "partner":"4nje" }, - { - "sim":55.0, - "partner":"5wqi" - }, { "sim":55.0, "partner":"5wqf" @@ -441670,28 +443632,12 @@ }, { "sim":55.0, - "partner":"6vll" - }, - { - "sim":55.0, - "partner":"5wg9" - }, - { - "sim":55.0, - "partner":"6v53" - }, - { - "sim":55.0, - "partner":"6wij" + "partner":"5wqi" }, { "sim":55.0, "partner":"5wap" }, - { - "sim":55.0, - "partner":"5web" - }, { "sim":55.0, "partner":"6v56" @@ -441706,7 +443652,7 @@ }, { "sim":55.0, - "partner":"5w7u" + "partner":"5web" }, { "sim":55.0, @@ -441720,6 +443666,10 @@ "sim":55.0, "partner":"6vg9" }, + { + "sim":55.0, + "partner":"5w7u" + }, { "sim":55.0, "partner":"5d8u" @@ -441734,39 +443684,39 @@ }, { "sim":55.0, - "partner":"5dbs" + "partner":"7kbc" }, { "sim":55.0, - "partner":"7kbc" + "partner":"5dbs" }, { "sim":55.0, - "partner":"5w9g" + "partner":"6v6x" }, { "sim":55.0, - "partner":"5vqn" + "partner":"6vjh" }, { "sim":55.0, - "partner":"5wdw" + "partner":"5w9g" }, { "sim":55.0, - "partner":"5wfz" + "partner":"7kny" }, { "sim":55.0, - "partner":"6v6x" + "partner":"5vqn" }, { "sim":55.0, - "partner":"6vjh" + "partner":"5wdw" }, { "sim":55.0, - "partner":"7kny" + "partner":"5wfz" }, { "sim":55.0, @@ -441782,7 +443732,11 @@ }, { "sim":55.0, - "partner":"5vpt" + "partner":"6vl3" + }, + { + "sim":55.0, + "partner":"6w7a" }, { "sim":55.0, @@ -441790,11 +443744,11 @@ }, { "sim":55.0, - "partner":"6vl3" + "partner":"5vpt" }, { "sim":55.0, - "partner":"6w7a" + "partner":"7k87" }, { "sim":55.0, @@ -441808,10 +443762,6 @@ "sim":55.0, "partner":"5wa6" }, - { - "sim":55.0, - "partner":"7k87" - }, { "sim":55.0, "partner":"5wa7" @@ -441826,7 +443776,7 @@ }, { "sim":55.0, - "partner":"5vrj" + "partner":"6wj4" }, { "sim":55.0, @@ -441834,7 +443784,7 @@ }, { "sim":55.0, - "partner":"6wj4" + "partner":"5vrj" }, { "sim":55.0, @@ -441842,19 +443792,19 @@ }, { "sim":55.0, - "partner":"7knr" + "partner":"6viv" }, { "sim":55.0, - "partner":"5w73" + "partner":"7knr" }, { "sim":55.0, - "partner":"6viv" + "partner":"7k77" }, { "sim":55.0, - "partner":"7k77" + "partner":"5w73" }, { "sim":55.0, @@ -441872,10 +443822,26 @@ "sim":55.0, "partner":"7lw6" }, + { + "sim":55.0, + "partner":"6vll" + }, { "sim":55.0, "partner":"7k0w" }, + { + "sim":55.0, + "partner":"6v53" + }, + { + "sim":55.0, + "partner":"6wij" + }, + { + "sim":55.0, + "partner":"5wg9" + }, { "sim":55.0, "partner":"7csz" @@ -441976,10 +443942,6 @@ "sim":54.0, "partner":"2q5z" }, - { - "sim":54.0, - "partner":"2vbq" - }, { "sim":54.0, "partner":"1s3z" @@ -441992,6 +443954,10 @@ "sim":54.0, "partner":"1s60" }, + { + "sim":54.0, + "partner":"2vbq" + }, { "sim":54.0, "partner":"5g4y" @@ -442064,10 +444030,6 @@ "sim":54.0, "partner":"3taz" }, - { - "sim":54.0, - "partner":"4cdm" - }, { "sim":54.0, "partner":"4cdn" @@ -442086,11 +444048,11 @@ }, { "sim":54.0, - "partner":"6rim" + "partner":"4cdm" }, { "sim":54.0, - "partner":"4dqw" + "partner":"6rim" }, { "sim":54.0, @@ -442100,6 +444062,10 @@ "sim":54.0, "partner":"6gk9" }, + { + "sim":54.0, + "partner":"4dqw" + }, { "sim":54.0, "partner":"5n6m" @@ -442120,10 +444086,6 @@ "sim":53.0, "partner":"6izs" }, - { - "sim":53.0, - "partner":"7p4y" - }, { "sim":53.0, "partner":"7p50" @@ -442136,6 +444098,10 @@ "sim":53.0, "partner":"7p4v" }, + { + "sim":53.0, + "partner":"7p4y" + }, { "sim":53.0, "partner":"7l99" @@ -442224,10 +444190,6 @@ "sim":53.0, "partner":"2va1" }, - { - "sim":53.0, - "partner":"3vms" - }, { "sim":53.0, "partner":"3vmt" @@ -442242,11 +444204,7 @@ }, { "sim":53.0, - "partner":"5ds3" - }, - { - "sim":53.0, - "partner":"6bhv" + "partner":"3vms" }, { "sim":53.0, @@ -442272,6 +444230,14 @@ "sim":53.0, "partner":"6nrj" }, + { + "sim":53.0, + "partner":"6bhv" + }, + { + "sim":53.0, + "partner":"5ds3" + }, { "sim":53.0, "partner":"4x7u" @@ -442318,11 +444284,11 @@ }, { "sim":53.0, - "partner":"6fcn" + "partner":"6fcm" }, { "sim":53.0, - "partner":"6fcm" + "partner":"6fcn" }, { "sim":53.0, @@ -442342,24 +444308,12 @@ }, { "sim":53.0, - "partner":"5coq" - }, - { - "sim":53.0, - "partner":"5cpb" - }, - { - "sim":53.0, - "partner":"5mtr" + "partner":"4oxk" }, { "sim":53.0, "partner":"5ugt" }, - { - "sim":53.0, - "partner":"4oxk" - }, { "sim":53.0, "partner":"5ugu" @@ -442370,15 +444324,15 @@ }, { "sim":53.0, - "partner":"4oxn" + "partner":"6yuu" }, { "sim":53.0, - "partner":"4oyr" + "partner":"4oxn" }, { "sim":53.0, - "partner":"6yuu" + "partner":"4oyr" }, { "sim":53.0, @@ -442404,25 +444358,33 @@ "sim":53.0, "partner":"5cp8" }, + { + "sim":53.0, + "partner":"5mtr" + }, { "sim":53.0, "partner":"5ugs" }, { "sim":53.0, - "partner":"5yc9" + "partner":"5cpb" }, { "sim":53.0, - "partner":"5xql" + "partner":"5coq" }, { "sim":53.0, - "partner":"3u3j" + "partner":"5yc9" }, { "sim":53.0, - "partner":"3u3r" + "partner":"5xql" + }, + { + "sim":53.0, + "partner":"3u3j" }, { "sim":53.0, @@ -442436,6 +444398,10 @@ "sim":53.0, "partner":"3u3o" }, + { + "sim":53.0, + "partner":"3u3r" + }, { "sim":53.0, "partner":"6zxm" @@ -442456,14 +444422,6 @@ "sim":53.0, "partner":"2qry" }, - { - "sim":53.0, - "partner":"5glm" - }, - { - "sim":53.0, - "partner":"5gln" - }, { "sim":53.0, "partner":"5glo" @@ -442488,6 +444446,14 @@ "sim":53.0, "partner":"5gll" }, + { + "sim":53.0, + "partner":"5glm" + }, + { + "sim":53.0, + "partner":"5gln" + }, { "sim":53.0, "partner":"2pvh" @@ -442520,22 +444486,6 @@ "sim":53.0, "partner":"4myg" }, - { - "sim":53.0, - "partner":"5zzx" - }, - { - "sim":53.0, - "partner":"6a0d" - }, - { - "sim":53.0, - "partner":"5zzy" - }, - { - "sim":53.0, - "partner":"6a0v" - }, { "sim":53.0, "partner":"5zzz" @@ -442676,6 +444626,22 @@ "sim":53.0, "partner":"6a21" }, + { + "sim":53.0, + "partner":"5zzx" + }, + { + "sim":53.0, + "partner":"6a0d" + }, + { + "sim":53.0, + "partner":"5zzy" + }, + { + "sim":53.0, + "partner":"6a0v" + }, { "sim":53.0, "partner":"4xau" @@ -442722,15 +444688,15 @@ }, { "sim":53.0, - "partner":"6v99" + "partner":"6v96" }, { "sim":53.0, - "partner":"6v9a" + "partner":"6v99" }, { "sim":53.0, - "partner":"6v96" + "partner":"6v9a" }, { "sim":53.0, @@ -442756,14 +444722,6 @@ "sim":53.0, "partner":"3s7y" }, - { - "sim":53.0, - "partner":"6mlh" - }, - { - "sim":53.0, - "partner":"6mlw" - }, { "sim":53.0, "partner":"6nn1" @@ -442788,6 +444746,14 @@ "sim":53.0, "partner":"6mlf" }, + { + "sim":53.0, + "partner":"6mlh" + }, + { + "sim":53.0, + "partner":"6mlw" + }, { "sim":53.0, "partner":"5bwf" @@ -442810,11 +444776,11 @@ }, { "sim":53.0, - "partner":"5ess" + "partner":"5esd" }, { "sim":53.0, - "partner":"5esd" + "partner":"5ess" }, { "sim":53.0, @@ -442870,35 +444836,35 @@ }, { "sim":53.0, - "partner":"3ahc" + "partner":"3ahf" }, { "sim":53.0, - "partner":"3ahd" + "partner":"3ahg" }, { "sim":53.0, - "partner":"3ahe" + "partner":"3ahh" }, { "sim":53.0, - "partner":"3ahf" + "partner":"3ahi" }, { "sim":53.0, - "partner":"3ahg" + "partner":"3ahj" }, { "sim":53.0, - "partner":"3ahh" + "partner":"3ahc" }, { "sim":53.0, - "partner":"3ahi" + "partner":"3ahd" }, { "sim":53.0, - "partner":"3ahj" + "partner":"3ahe" }, { "sim":52.0, @@ -442978,11 +444944,11 @@ }, { "sim":52.0, - "partner":"4gzc" + "partner":"4gzd" }, { "sim":52.0, - "partner":"4gzd" + "partner":"4gzc" }, { "sim":52.0, @@ -443002,11 +444968,11 @@ }, { "sim":52.0, - "partner":"6z0x" + "partner":"6z0y" }, { "sim":52.0, - "partner":"6z0y" + "partner":"6z0x" }, { "sim":52.0, @@ -443090,15 +445056,15 @@ }, { "sim":52.0, - "partner":"1zw3" + "partner":"1zvz" }, { "sim":52.0, - "partner":"1zvz" + "partner":"1zw2" }, { "sim":52.0, - "partner":"1zw2" + "partner":"1zw3" }, { "sim":52.0, @@ -443106,11 +445072,11 @@ }, { "sim":52.0, - "partner":"4rdh" + "partner":"4rdi" }, { "sim":52.0, - "partner":"4rdi" + "partner":"4rdh" }, { "sim":52.0, @@ -443164,10 +445130,6 @@ "sim":52.0, "partner":"3a99" }, - { - "sim":52.0, - "partner":"3aio" - }, { "sim":52.0, "partner":"3aik" @@ -443184,21 +445146,25 @@ "sim":52.0, "partner":"3ain" }, + { + "sim":52.0, + "partner":"3aio" + }, { "sim":52.0, "partner":"3rlh" }, { "sim":52.0, - "partner":"6q4x" + "partner":"6q4z" }, { "sim":52.0, - "partner":"6q4y" + "partner":"6q4x" }, { "sim":52.0, - "partner":"6q4z" + "partner":"6q4y" }, { "sim":52.0, @@ -443238,23 +445204,23 @@ }, { "sim":52.0, - "partner":"6zgp" + "partner":"6y9d" }, { "sim":52.0, - "partner":"6y8j" + "partner":"6zgp" }, { "sim":52.0, - "partner":"6y9c" + "partner":"6y8s" }, { "sim":52.0, - "partner":"6y9d" + "partner":"6y8j" }, { "sim":52.0, - "partner":"6y8s" + "partner":"6y9c" }, { "sim":52.0, @@ -443310,15 +445276,15 @@ }, { "sim":52.0, - "partner":"7cl7" + "partner":"6l69" }, { "sim":52.0, - "partner":"7cl8" + "partner":"7cl7" }, { "sim":52.0, - "partner":"6l69" + "partner":"7cl8" }, { "sim":52.0, @@ -443344,21 +445310,17 @@ "sim":52.0, "partner":"6j0u" }, - { - "sim":52.0, - "partner":"6ak4" - }, { "sim":52.0, "partner":"6aej" }, { "sim":52.0, - "partner":"5kr5" + "partner":"6ak4" }, { "sim":52.0, - "partner":"7f79" + "partner":"5kr5" }, { "sim":52.0, @@ -443366,11 +445328,11 @@ }, { "sim":52.0, - "partner":"6akw" + "partner":"7f79" }, { "sim":52.0, - "partner":"4ie7" + "partner":"6akw" }, { "sim":52.0, @@ -443390,15 +445352,15 @@ }, { "sim":52.0, - "partner":"4idz" + "partner":"7e8z" }, { "sim":52.0, - "partner":"4ie0" + "partner":"4idz" }, { "sim":52.0, - "partner":"7e8z" + "partner":"4ie0" }, { "sim":52.0, @@ -443416,6 +445378,10 @@ "sim":52.0, "partner":"4qho" }, + { + "sim":52.0, + "partner":"4ie7" + }, { "sim":52.0, "partner":"4pxg" @@ -443580,21 +445546,17 @@ "sim":51.0, "partner":"4tns" }, - { - "sim":51.0, - "partner":"3faj" - }, { "sim":51.0, "partner":"7dvi" }, { "sim":51.0, - "partner":"2xga" + "partner":"3faj" }, { "sim":51.0, - "partner":"3rg6" + "partner":"2xga" }, { "sim":51.0, @@ -443610,7 +445572,7 @@ }, { "sim":51.0, - "partner":"5hso" + "partner":"3rg6" }, { "sim":51.0, @@ -443628,6 +445590,10 @@ "sim":51.0, "partner":"5hsm" }, + { + "sim":51.0, + "partner":"5hso" + }, { "sim":51.0, "partner":"6bws" @@ -443678,15 +445644,15 @@ }, { "sim":51.0, - "partner":"1x24" + "partner":"1zcl" }, { "sim":51.0, - "partner":"1zcl" + "partner":"7ckv" }, { "sim":51.0, - "partner":"7ckv" + "partner":"1x24" }, { "sim":51.0, @@ -443722,15 +445688,11 @@ }, { "sim":51.0, - "partner":"6pj9" - }, - { - "sim":51.0, - "partner":"6pja" + "partner":"6pjp" }, { "sim":51.0, - "partner":"6pjp" + "partner":"6pjq" }, { "sim":51.0, @@ -443738,11 +445700,11 @@ }, { "sim":51.0, - "partner":"6pjq" + "partner":"6pjr" }, { "sim":51.0, - "partner":"6pjr" + "partner":"6pju" }, { "sim":51.0, @@ -443752,10 +445714,6 @@ "sim":51.0, "partner":"5f5d" }, - { - "sim":51.0, - "partner":"6pju" - }, { "sim":51.0, "partner":"4njp" @@ -443782,15 +445740,19 @@ }, { "sim":51.0, - "partner":"5f5j" + "partner":"6pj5" }, { "sim":51.0, - "partner":"6pj5" + "partner":"6pj7" }, { "sim":51.0, - "partner":"6pj7" + "partner":"5f5j" + }, + { + "sim":51.0, + "partner":"6pj8" }, { "sim":51.0, @@ -443798,11 +445760,11 @@ }, { "sim":51.0, - "partner":"6pj8" + "partner":"6pj9" }, { "sim":51.0, - "partner":"2fzl" + "partner":"6pja" }, { "sim":51.0, @@ -443826,11 +445788,11 @@ }, { "sim":51.0, - "partner":"3l4c" + "partner":"2fzl" }, { "sim":51.0, - "partner":"6j0l" + "partner":"3l4c" }, { "sim":51.0, @@ -443842,7 +445804,7 @@ }, { "sim":51.0, - "partner":"6wae" + "partner":"6j0l" }, { "sim":51.0, @@ -443856,6 +445818,10 @@ "sim":51.0, "partner":"6wai" }, + { + "sim":51.0, + "partner":"6wae" + }, { "sim":51.0, "partner":"3tjn" @@ -443882,35 +445848,35 @@ }, { "sim":51.0, - "partner":"2fz4" + "partner":"3x22" }, { "sim":51.0, - "partner":"3x22" + "partner":"2fz4" }, { "sim":51.0, - "partner":"3la7" + "partner":"5cve" }, { "sim":51.0, - "partner":"5cvd" + "partner":"3la2" }, { "sim":51.0, - "partner":"5cve" + "partner":"6kdq" }, { "sim":51.0, - "partner":"3la2" + "partner":"3la3" }, { "sim":51.0, - "partner":"3la3" + "partner":"5cvd" }, { "sim":51.0, - "partner":"6kdq" + "partner":"3la7" }, { "sim":51.0, @@ -443928,10 +445894,6 @@ "sim":51.0, "partner":"3r6s" }, - { - "sim":51.0, - "partner":"4da6" - }, { "sim":51.0, "partner":"4da7" @@ -443988,6 +445950,10 @@ "sim":51.0, "partner":"4d8v" }, + { + "sim":51.0, + "partner":"4da6" + }, { "sim":51.0, "partner":"5t38" @@ -444022,11 +445988,11 @@ }, { "sim":51.0, - "partner":"6hxo" + "partner":"6hxn" }, { "sim":51.0, - "partner":"6hxn" + "partner":"6hxo" }, { "sim":51.0, @@ -444034,39 +446000,39 @@ }, { "sim":51.0, - "partner":"3quo" + "partner":"3qur" }, { "sim":51.0, - "partner":"3qvf" + "partner":"4rnj" }, { "sim":51.0, - "partner":"4rni" + "partner":"3qvh" }, { "sim":51.0, - "partner":"4rnj" + "partner":"3d40" }, { "sim":51.0, - "partner":"3qur" + "partner":"3d41" }, { "sim":51.0, - "partner":"3qvh" + "partner":"3qun" }, { "sim":51.0, - "partner":"3d40" + "partner":"3quo" }, { "sim":51.0, - "partner":"3d41" + "partner":"3qvf" }, { "sim":51.0, - "partner":"3qun" + "partner":"4rni" }, { "sim":51.0, @@ -444122,19 +446088,19 @@ }, { "sim":51.0, - "partner":"3nha" + "partner":"3nh6" }, { "sim":51.0, - "partner":"3nhb" + "partner":"3nh9" }, { "sim":51.0, - "partner":"3nh6" + "partner":"3nha" }, { "sim":51.0, - "partner":"3nh9" + "partner":"3nhb" }, { "sim":51.0, @@ -444144,25 +446110,13 @@ "sim":51.0, "partner":"3zgc" }, - { - "sim":51.0, - "partner":"3zgd" - }, { "sim":51.0, "partner":"7dt2" }, { "sim":51.0, - "partner":"3nc2" - }, - { - "sim":51.0, - "partner":"3q92" - }, - { - "sim":51.0, - "partner":"3ro4" + "partner":"3zgd" }, { "sim":51.0, @@ -444196,6 +446150,10 @@ "sim":51.0, "partner":"5wbq" }, + { + "sim":51.0, + "partner":"6w0w" + }, { "sim":51.0, "partner":"5wbr" @@ -444206,7 +446164,7 @@ }, { "sim":51.0, - "partner":"6w0w" + "partner":"6w0x" }, { "sim":51.0, @@ -444214,19 +446172,19 @@ }, { "sim":51.0, - "partner":"6w0x" + "partner":"6w0n" }, { "sim":51.0, - "partner":"3qai" + "partner":"6w0y" }, { "sim":51.0, - "partner":"6w0n" + "partner":"3qai" }, { "sim":51.0, - "partner":"6w0y" + "partner":"6w0z" }, { "sim":51.0, @@ -444234,11 +446192,15 @@ }, { "sim":51.0, - "partner":"6w0z" + "partner":"3nc2" }, { "sim":51.0, - "partner":"5ybr" + "partner":"3q92" + }, + { + "sim":51.0, + "partner":"3ro4" }, { "sim":51.0, @@ -444268,6 +446230,10 @@ "sim":51.0, "partner":"5ybq" }, + { + "sim":51.0, + "partner":"5ybr" + }, { "sim":51.0, "partner":"1l9x" @@ -444324,10 +446290,6 @@ "sim":51.0, "partner":"3pdc" }, - { - "sim":51.0, - "partner":"1t9s" - }, { "sim":51.0, "partner":"1mx3" @@ -444348,6 +446310,10 @@ "sim":51.0, "partner":"1tbf" }, + { + "sim":51.0, + "partner":"1t9s" + }, { "sim":51.0, "partner":"1qyu" @@ -444414,15 +446380,15 @@ }, { "sim":51.0, - "partner":"6vkk" + "partner":"6vko" }, { "sim":51.0, - "partner":"6vkq" + "partner":"6vkk" }, { "sim":51.0, - "partner":"6vko" + "partner":"6vkq" }, { "sim":51.0, @@ -444504,10 +446470,6 @@ "sim":51.0, "partner":"4ihe" }, - { - "sim":51.0, - "partner":"2imc" - }, { "sim":51.0, "partner":"2ilp" @@ -444532,6 +446494,10 @@ "sim":51.0, "partner":"2imb" }, + { + "sim":51.0, + "partner":"2imc" + }, { "sim":51.0, "partner":"4kuf" @@ -444578,15 +446544,15 @@ }, { "sim":51.0, - "partner":"5v1s" + "partner":"5v1t" }, { "sim":51.0, - "partner":"5v1t" + "partner":"5v1q" }, { "sim":51.0, - "partner":"5v1q" + "partner":"5v1s" }, { "sim":51.0, @@ -444600,10 +446566,6 @@ "sim":51.0, "partner":"7d4n" }, - { - "sim":51.0, - "partner":"4acg" - }, { "sim":51.0, "partner":"4ach" @@ -444616,6 +446578,10 @@ "sim":51.0, "partner":"4acd" }, + { + "sim":51.0, + "partner":"4acg" + }, { "sim":51.0, "partner":"6ec3" @@ -444672,10 +446638,6 @@ "sim":51.0, "partner":"5n6l" }, - { - "sim":51.0, - "partner":"6vgs" - }, { "sim":51.0, "partner":"6spn" @@ -444696,6 +446658,10 @@ "sim":51.0, "partner":"6spr" }, + { + "sim":51.0, + "partner":"6vgs" + }, { "sim":51.0, "partner":"6ojk" @@ -444732,22 +446698,6 @@ "sim":51.0, "partner":"6dcr" }, - { - "sim":51.0, - "partner":"5xrv" - }, - { - "sim":51.0, - "partner":"5xtv" - }, - { - "sim":51.0, - "partner":"5i4i" - }, - { - "sim":51.0, - "partner":"5xt4" - }, { "sim":51.0, "partner":"5xtl" @@ -444832,6 +446782,22 @@ "sim":51.0, "partner":"5hyv" }, + { + "sim":51.0, + "partner":"5xrv" + }, + { + "sim":51.0, + "partner":"5xtv" + }, + { + "sim":51.0, + "partner":"5i4i" + }, + { + "sim":51.0, + "partner":"5xt4" + }, { "sim":51.0, "partner":"4put" @@ -444862,15 +446828,15 @@ }, { "sim":51.0, - "partner":"6tsh" + "partner":"6tsk" }, { "sim":51.0, - "partner":"6tte" + "partner":"6tsh" }, { "sim":51.0, - "partner":"6tsk" + "partner":"6tte" }, { "sim":50.0, @@ -444954,15 +446920,15 @@ }, { "sim":50.0, - "partner":"4hmr" + "partner":"4hls" }, { "sim":50.0, - "partner":"4hls" + "partner":"4hmm" }, { "sim":50.0, - "partner":"4hmm" + "partner":"4hmr" }, { "sim":50.0, @@ -445024,10 +446990,6 @@ "sim":50.0, "partner":"4elz" }, - { - "sim":50.0, - "partner":"4y26" - }, { "sim":50.0, "partner":"4y1u" @@ -445056,6 +447018,10 @@ "sim":50.0, "partner":"4y24" }, + { + "sim":50.0, + "partner":"4y26" + }, { "sim":50.0, "partner":"3i93" @@ -445114,7 +447080,7 @@ }, { "sim":50.0, - "partner":"5edd" + "partner":"8p8o" }, { "sim":50.0, @@ -445132,33 +447098,29 @@ "sim":50.0, "partner":"3h6d" }, - { - "sim":50.0, - "partner":"1snf" - }, { "sim":50.0, "partner":"7kzg" }, { "sim":50.0, - "partner":"1six" + "partner":"1snf" }, { "sim":50.0, - "partner":"1slh" + "partner":"1six" }, { "sim":50.0, - "partner":"3loj" + "partner":"7kz0" }, { "sim":50.0, - "partner":"7kz0" + "partner":"1slh" }, { "sim":50.0, - "partner":"8p8o" + "partner":"3loj" }, { "sim":50.0, @@ -445176,6 +447138,10 @@ "sim":50.0, "partner":"3hza" }, + { + "sim":50.0, + "partner":"5edd" + }, { "sim":50.0, "partner":"7cbs" @@ -445202,11 +447168,11 @@ }, { "sim":50.0, - "partner":"6uv7" + "partner":"6uvi" }, { "sim":50.0, - "partner":"6uvi" + "partner":"6uv7" }, { "sim":50.0, @@ -445386,15 +447352,15 @@ }, { "sim":50.0, - "partner":"6wye" + "partner":"5e0n" }, { "sim":50.0, - "partner":"5e0n" + "partner":"7ra4" }, { "sim":50.0, - "partner":"7ra4" + "partner":"6wye" }, { "sim":50.0, @@ -445418,11 +447384,11 @@ }, { "sim":50.0, - "partner":"3ta4" + "partner":"3t9w" }, { "sim":50.0, - "partner":"3t9w" + "partner":"3ta4" }, { "sim":50.0, @@ -445458,23 +447424,23 @@ }, { "sim":50.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":50.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":50.0, - "partner":"3tm8" + "partner":"6unx" }, { "sim":50.0, - "partner":"3tmb" + "partner":"3tmc" }, { "sim":50.0, - "partner":"6unx" + "partner":"3tmd" }, { "sim":50.0, @@ -445508,21 +447474,17 @@ "sim":50.0, "partner":"3il5" }, - { - "sim":50.0, - "partner":"6cwo" - }, { "sim":50.0, "partner":"4xq6" }, { "sim":50.0, - "partner":"7js3" + "partner":"6cwo" }, { "sim":50.0, - "partner":"2ikf" + "partner":"7js3" }, { "sim":50.0, @@ -445552,6 +447514,10 @@ "sim":50.0, "partner":"5kal" }, + { + "sim":50.0, + "partner":"2ikf" + }, { "sim":50.0, "partner":"1m1m" @@ -445584,10 +447550,6 @@ "sim":50.0, "partner":"4ocv" }, - { - "sim":50.0, - "partner":"6put" - }, { "sim":50.0, "partner":"6puw" @@ -445602,15 +447564,15 @@ }, { "sim":50.0, - "partner":"5u1c" + "partner":"6puz" }, { "sim":50.0, - "partner":"6puz" + "partner":"5u1c" }, { "sim":50.0, - "partner":"5hxu" + "partner":"6put" }, { "sim":50.0, @@ -445626,15 +447588,11 @@ }, { "sim":50.0, - "partner":"2qdh" - }, - { - "sim":50.0, - "partner":"6kjh" + "partner":"5hxu" }, { "sim":50.0, - "partner":"6kjj" + "partner":"2qdh" }, { "sim":50.0, @@ -445660,6 +447618,14 @@ "sim":50.0, "partner":"2qdg" }, + { + "sim":50.0, + "partner":"6kjh" + }, + { + "sim":50.0, + "partner":"6kjj" + }, { "sim":50.0, "partner":"6c8v" @@ -445718,11 +447684,11 @@ }, { "sim":50.0, - "partner":"5xw2" + "partner":"4e2p" }, { "sim":50.0, - "partner":"4e2p" + "partner":"5xw2" }, { "sim":50.0, @@ -445752,10 +447718,6 @@ "sim":50.0, "partner":"2zvi" }, - { - "sim":50.0, - "partner":"5cu7" - }, { "sim":50.0, "partner":"4fdt" @@ -445768,6 +447730,10 @@ "sim":50.0, "partner":"5cx4" }, + { + "sim":50.0, + "partner":"5cu7" + }, { "sim":50.0, "partner":"6n67" @@ -445862,11 +447828,11 @@ }, { "sim":50.0, - "partner":"4dqv" + "partner":"4u5q" }, { "sim":50.0, - "partner":"4u5q" + "partner":"4dqv" }, { "sim":50.0, @@ -445880,14 +447846,6 @@ "sim":50.0, "partner":"5hat" }, - { - "sim":50.0, - "partner":"5hjx" - }, - { - "sim":50.0, - "partner":"5koz" - }, { "sim":50.0, "partner":"5hjy" @@ -445908,6 +447866,10 @@ "sim":50.0, "partner":"3oqc" }, + { + "sim":50.0, + "partner":"5koz" + }, { "sim":50.0, "partner":"4lf2" @@ -445916,6 +447878,10 @@ "sim":50.0, "partner":"5hk4" }, + { + "sim":50.0, + "partner":"5hjx" + }, { "sim":50.0, "partner":"5hqm" @@ -445932,21 +447898,17 @@ "sim":50.0, "partner":"6pnu" }, - { - "sim":50.0, - "partner":"4mdo" - }, { "sim":50.0, "partner":"4mdp" }, { "sim":50.0, - "partner":"6m5w" + "partner":"4mdo" }, { "sim":50.0, - "partner":"5klk" + "partner":"6m5w" }, { "sim":50.0, @@ -445968,6 +447930,10 @@ "sim":50.0, "partner":"5kj5" }, + { + "sim":50.0, + "partner":"5klk" + }, { "sim":50.0, "partner":"5o3m" @@ -445990,11 +447956,11 @@ }, { "sim":50.0, - "partner":"6crm" + "partner":"4tmu" }, { "sim":50.0, - "partner":"4tmu" + "partner":"6crm" }, { "sim":50.0, @@ -446002,27 +447968,27 @@ }, { "sim":50.0, - "partner":"4ids" + "partner":"4lem" }, { "sim":50.0, - "partner":"4jdc" + "partner":"4idm" }, { "sim":50.0, - "partner":"4lem" + "partner":"4ns3" }, { "sim":50.0, - "partner":"4idm" + "partner":"4ihi" }, { "sim":50.0, - "partner":"4ns3" + "partner":"4ids" }, { "sim":50.0, - "partner":"4ihi" + "partner":"4jdc" }, { "sim":50.0, @@ -446106,15 +448072,15 @@ }, { "sim":50.0, - "partner":"5lj7" + "partner":"5lil" }, { "sim":50.0, - "partner":"5lil" + "partner":"5lj6" }, { "sim":50.0, - "partner":"5lj6" + "partner":"5lj7" }, { "sim":50.0, @@ -446241,10 +448207,10 @@ "subtitle":"Solution nmr structure of de novo designed rossmann 3x3 fold protein r3x3_bp3, northeast structural genomics consortium (nesg) target or689", "tags":[ "rossmann 3x3 fold", + "nesg", + "de novo protein", "northeast structural genomics consortium", "structural genomics", - "de novo protein", - "nesg", "psi-biology" ], "keywords":[ @@ -446435,90 +448401,90 @@ ], "subtitle":"High-throughput design and refinement of stable proteins using sequence-only models", "tags":[ - "evaluator model", - "de novo designed", + "de novo protein", "deep network hallucination", + "evaluator model", "neural network", - "de novo protein" + "de novo designed" ], "keywords":[ - "work", - "many", - "predictive", + "finally", + "show", "noisy", - "providing", - "must", - "use", + "within", "acid", - "time", - "including", - "substantially", - "designed", - "experimentally", - "generally", - "find", - "show", - "order", - "sequences", - "structure", - "computationally", - "able", - "however", - "novel", - "achieve", + "model", "network", + "perturbations", + "protein", + "given", + "neural", + "rare", + "predictive", + "stable", + "secondary", + "achieve", + "terms", + "engineered", + "however", + "ones", + "able", + "include", + "computationally", + "predicts", + "experimentally", + "consequence", + "stability", "proteins", "expensive", - "assay", - "compare", - "finally", - "used", - "include", + "generally", + "use", "future", - "assayed", - "function", + "including", + "values", + "increase", + "resources", "requested", - "consequence", + "another", + "work", + "must", + "astronomically", + "used", + "possible", "field", - "stability", + "compare", + "tested", + "approximately", + "also", "performance", - "data", - "another", + "build", "amino", - "generate", - "report", - "acids", - "model", - "secondary", - "neural", + "wide", + "evaluate", + "time", "sequence", - "resources", - "increase", - "predicts", - "ones", + "substantially", "range", - "designs", - "rare", - "tested", - "build", - "values", - "also", - "evaluate", - "stable", - "wide", - "engineered", - "terms", - "approximately", - "weaknesses", - "possess", - "protein", - "given", + "designed", + "assay", + "order", + "sequences", + "many", "space", + "providing", + "structure", + "possess", + "report", + "function", + "assayed", "baseline", - "within", - "possible", - "perturbations", - "astronomically" + "find", + "weaknesses", + "acids", + "data", + "designs", + "generate", + "novel" ], "release_date":"2021-12-15", "publication":"\"Large-scale design and refinement of stable proteins using sequence-only models\", Plos One, 17, e0265020-e0265020", @@ -446642,10 +448608,10 @@ ], "subtitle":"X-ray structure of a cu-bound de novo designed peptide trimer", "tags":[ - "metallopeptide", - "de novo protein", "coiled coil", + "metallopeptide", "copper", + "de novo protein", "artificial enzymes" ], "keywords":[ @@ -446770,92 +448736,92 @@ "de novo designed" ], "keywords":[ - "hence", - "compromising", - "including", - "designed", - "shapes", - "provide", + "engineering", + "molecular", + "recognition", + "structural", + "learning", "methods", + "serving", + "single", + "dataset", + "new", + "machine", + "folding", + "protein", + "accurate", + "massive", + "novo", + "variety", + "stable", + "rules", + "resource", "experimentally", - "features", - "sampling", + "furthermore", + "define", + "identified", + "functions", + "control", + "thioredoxin", "basis", - "designing", - "diversity", - "predict", - "novel", - "dataset", - "without", + "stability", "proteins", - "training", - "de", + "eight", + "shapes", "small", - "necessary", - "recognition", - "beyond", - "nature", + "predict", "sometimes", - "resource", - "furthermore", - "massive", - "function", - "revealed", - "rules", - "platform", - "stability", - "fraction", - "control", - "data", + "features", + "computational", + "including", "obtained", - "molecular", - "loops", - "amino", - "classifier", - "serving", - "accurate", - "among", - "acids", - "define", - "shape", - "functions", - "engineering", - "provides", + "designing", "design", - "sequence", - "variations", - "minimalized", - "functionalities", - "learning", - "structural", - "machine", - "predicted", - "range", - "sample", + "sampling", + "classifier", "diverse", - "designs", - "eight", + "provides", + "loops", + "hence", + "different", + "platform", + "samples", + "fold", + "diversity", + "beyond", "also", - "stable", - "single", + "explore", + "amino", "wide", - "novo", - "thioredoxin", - "fold", - "samples", - "different", - "identified", "validated", + "functionalities", + "predicted", + "sequence", + "developed", + "evaluated", + "range", "folds", - "explore", - "protein", + "designed", + "revealed", "space", - "variety", - "evaluated", - "computational", - "folding", - "developed", - "new" + "de", + "training", + "without", + "among", + "shape", + "provide", + "nature", + "necessary", + "function", + "compromising", + "fraction", + "sample", + "acids", + "data", + "designs", + "minimalized", + "variations", + "novel" ], "release_date":"2022-07-13", "publication":"\"Sampling of structure and sequence space of small protein folds\", Nat Commun, 13, 7151-7151", @@ -446964,64 +448930,64 @@ "beta-2-microglobulin" ], "keywords":[ - "studies", - "proteins", - "use", - "inducing", - "begins", + "conformation", + "regardless", + "orn", + "allow", + "adopt", + "affords", + "show", + "spectroscopy", + "provides", + "\u03b4", + "suitable", + "macrocyclic", + "r", + "previously", + "widespread", + "comparable", + "structure", + "synthesis", "n", "report", + "tool", "although", - "\u03b3", - "ornithine", + "block", + "folding", + "cd", "template", "crystallography", - "peptide", - "substantially", - "peptides", - "cd", - "spectroscopy", - "allow", - "small", - "synthesis", - "meorn", - "improved", - "regardless", + "nmr", "quantities", - "unit", + "meorn", + "popular", "folded", - "provides", - "confirms", - "better", - "affords", - "comparison", - "introduced", - "show", - "comparable", + "unit", + "proteins", + "improved", + "protected", "\u03b1", - "conformation", - "adopt", - "\u03b4", + "confirms", + "use", + "ornithine", "adopts", - "r", - "nmr", - "structure", - "popular", + "coax", "sequence", - "block", - "widespread", - "suitable", - "macrocyclic", - "turn", - "orn", "building", + "small", + "substantially", + "peptides", + "turn", "gram", - "protected", - "folding", - "coax", "developed", - "tool", - "previously" + "studies", + "inducing", + "introduced", + "better", + "peptide", + "\u03b3", + "begins", + "comparison" ], "release_date":"2021-08-11", "publication":"\"An Improved Turn Structure for Inducing beta-Hairpin Formation in Peptides\", Angew.Chem.Int.Ed.Engl., 60, 22776-22782", @@ -447274,89 +449240,89 @@ ], "subtitle":"Specific inhibitor of integrin alpha-v beta-6", "tags":[ - "inhibitor", - "integrin", - "fibrosis", + "de novo design", "de novo protein", - "de novo design" + "fibrosis", + "inhibitor", + "integrin" ], "keywords":[ - "stability", - "thermal", - "hence", - "\u03b1v\u03b28", - "considerable", - "importance", - "overall", - "fibrotic", + "molecule", + "affinity", + "designed", + "potently", + "designing", + "homologous", "models", - "proteins", + "fibrosis", + "miniproteins", "conformational", + "design", + "hyperstable", + "show", + "structures", "complexes", - "close", - "de", "discriminate", - "clinically", - "antibody", "single", - "inhibitor", - "novo", - "miniproteins", - "method", - "homologous", - "designed", - "lung", + "de", "generalized", - "demonstrating", - "small", + "hence", "approaches", - "needed", - "selectivity", + "computationally", + "fibrotic", + "overall", + "mechanics", + "potential", + "properties", + "rgd", "specific", - "improved", - "validated", + "selective", "heterodimer", + "lung", + "targets", + "inhibitor", "new", - "state", + "therapeutic", "burden", - "\u03b1v\u03b26", - "stabilize", - "picomolar", - "integrins", - "design", - "selective", - "show", - "mouse", - "fibrosis", + "integrin", "model", - "structures", - "rgd", + "thermal", + "cryoem", + "state", + "\u03b1v\u03b28", + "inhibitors", "bind", + "selectivity", + "stability", "reduced", + "improved", + "proteins", + "binding", + "utility", + "close", + "validated", + "considerable", + "high", + "novo", + "compounds", "states", - "targets", + "small", + "picomolar", + "\u03b1v\u03b26", "existing", - "designing", + "integrins", + "stabilize", "describe", - "high", - "mechanics", - "cryoem", - "hyperstable", - "compounds", - "computationally", - "potently", - "could", - "inhibitors", - "integrin", + "mouse", + "demonstrating", + "method", + "clinically", "computational", - "potential", - "affinity", "cancer", - "therapeutic", - "binding", - "molecule", - "utility", - "properties" + "importance", + "could", + "antibody", + "needed" ], "release_date":"2022-08-10", "publication":"\"De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8\", Nat Commun, 14, 5660-5660", @@ -447613,89 +449579,89 @@ ], "subtitle":"A highly specific inhibitor of integrin alpha-v beta-6 with a disulfide", "tags":[ - "inhibitor", - "integrin", - "fibrosis", + "de novo design", "de novo protein", - "de novo design" + "fibrosis", + "inhibitor", + "integrin" ], "keywords":[ - "stability", - "thermal", - "hence", - "\u03b1v\u03b28", - "considerable", - "importance", - "overall", - "fibrotic", + "molecule", + "affinity", + "designed", + "potently", + "designing", + "homologous", "models", - "proteins", + "fibrosis", + "miniproteins", "conformational", + "design", + "hyperstable", + "show", + "structures", "complexes", - "close", - "de", "discriminate", - "clinically", - "antibody", "single", - "inhibitor", - "novo", - "miniproteins", - "method", - "homologous", - "designed", - "lung", + "de", "generalized", - "demonstrating", - "small", + "hence", "approaches", - "needed", - "selectivity", + "computationally", + "fibrotic", + "overall", + "mechanics", + "potential", + "properties", + "rgd", "specific", - "improved", - "validated", + "selective", "heterodimer", + "lung", + "targets", + "inhibitor", "new", - "state", + "therapeutic", "burden", - "\u03b1v\u03b26", - "stabilize", - "picomolar", - "integrins", - "design", - "selective", - "show", - "mouse", - "fibrosis", + "integrin", "model", - "structures", - "rgd", + "thermal", + "cryoem", + "state", + "\u03b1v\u03b28", + "inhibitors", "bind", + "selectivity", + "stability", "reduced", + "improved", + "proteins", + "binding", + "utility", + "close", + "validated", + "considerable", + "high", + "novo", + "compounds", "states", - "targets", + "small", + "picomolar", + "\u03b1v\u03b26", "existing", - "designing", + "integrins", + "stabilize", "describe", - "high", - "mechanics", - "cryoem", - "hyperstable", - "compounds", - "computationally", - "potently", - "could", - "inhibitors", - "integrin", + "mouse", + "demonstrating", + "method", + "clinically", "computational", - "potential", - "affinity", "cancer", - "therapeutic", - "binding", - "molecule", - "utility", - "properties" + "importance", + "could", + "antibody", + "needed" ], "release_date":"2022-08-10", "publication":"\"De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8\", Nat Commun, 14, 5660-5660", @@ -447807,9 +449773,9 @@ ], "subtitle":"Collagen mimetic peptide with an xaa-position aza-proline", "tags":[ - "collagen", "aza-amino acid", - "biosynthetic protein" + "biosynthetic protein", + "collagen" ], "keywords":[ "description", @@ -447911,10 +449877,10 @@ ], "subtitle":"Collagen mimetic peptide with a yaa-position aza-proline", "tags":[ - "collagen", "aza-amino acid", + "structural protein", "biosynthetic protein", - "structural protein" + "collagen" ], "keywords":[ "description", @@ -448048,88 +450014,88 @@ ], "subtitle":"Computational design of constitutively active cgas", "tags":[ - "constitutive mutant", - "cgas", "de novo protein", - "de novo designed" + "constitutive mutant", + "de novo designed", + "cgas" ], "keywords":[ + "designed", + "conformation", + "activate", + "tumorigenesis", + "recognition", + "critical", + "design", + "conformational", + "intracellular", + "constitutively", + "vivo", "work", - "framework", + "variants", + "cgamp", + "active", + "provides", "ifn", - "general", - "inflammatory", - "directly", - "critical", - "proteins", "stabilizing", - "adoption", - "conformational", - "regression", - "dna", - "damage", - "potent", - "resulted", - "changes", - "tumorigenesis", "pattern", "produce", - "combined", - "synthase", - "response", - "therapeutically", - "intracellular", - "senescence", + "adjuvants", + "dna", + "biological", + "identified", + "framework", + "regression", + "could", + "cyclic", + "damage", "crystallography", - "enzymes", - "variants", - "enzyme", - "pathogens", - "designed", - "tools", - "receptor", - "dsdna", - "confirmed", - "demonstrating", "immune", - "constitutively", - "active", + "adoption", "relevant", "useful", - "recognition", - "activity", - "identified", - "induces", + "dsdna", + "understanding", + "combined", + "response", + "pathogens", + "binding", + "changes", + "mutants", + "resulted", + "proteins", "innate", - "provides", - "messenger", - "adjuvants", - "design", - "expression", - "cgas", - "conformation", "genetically", - "cgamp", + "approaching", "initiates", - "tumor", "interferon", - "biological", - "encoded", - "understanding", - "computational", - "vivo", - "mutants", - "could", - "diseases", "sting", + "confirmed", + "therapeutically", + "tumor", + "senescence", + "activity", "cells", - "second", + "general", + "enzyme", + "enzymes", + "diseases", + "inflammatory", + "expression", "conformations", - "binding", - "cyclic", + "potent", + "encoded", + "synthase", + "second", "create", - "approaching", - "activate" + "demonstrating", + "messenger", + "computational", + "tools", + "receptor", + "induces", + "cgas", + "directly" ], "release_date":"2022-03-16", "publication":"\"Computational design of constitutively active cGAS\", Nat.Struct.Mol.Biol., 30, 72-80", @@ -448167,10 +450133,6 @@ "sim":736.0, "partner":"7kxs" }, - { - "sim":719.0, - "partner":"4k97" - }, { "sim":719.0, "partner":"4k98" @@ -448203,17 +450165,21 @@ "sim":719.0, "partner":"4k96" }, + { + "sim":719.0, + "partner":"4k97" + }, { "sim":718.0, "partner":"7buj" }, { "sim":718.0, - "partner":"7bum" + "partner":"7buq" }, { "sim":718.0, - "partner":"7buq" + "partner":"7bum" }, { "sim":717.0, @@ -448245,15 +450211,15 @@ }, { "sim":717.0, - "partner":"6x59" + "partner":"6x5a" }, { "sim":717.0, - "partner":"6x5a" + "partner":"6xjd" }, { "sim":717.0, - "partner":"6xjd" + "partner":"6x59" }, { "sim":708.0, @@ -448283,10 +450249,6 @@ "sim":487.0, "partner":"6edc" }, - { - "sim":486.0, - "partner":"6nfo" - }, { "sim":486.0, "partner":"6nfg" @@ -448301,7 +450263,7 @@ }, { "sim":486.0, - "partner":"4o67" + "partner":"6nfo" }, { "sim":486.0, @@ -448343,6 +450305,10 @@ "sim":486.0, "partner":"5vdw" }, + { + "sim":486.0, + "partner":"4o67" + }, { "sim":486.0, "partner":"6edb" @@ -448357,11 +450323,11 @@ }, { "sim":485.0, - "partner":"6lre" + "partner":"7ccr" }, { "sim":485.0, - "partner":"7ccr" + "partner":"6lre" }, { "sim":485.0, @@ -448389,11 +450355,11 @@ }, { "sim":485.0, - "partner":"4km5" + "partner":"4lev" }, { "sim":485.0, - "partner":"4lev" + "partner":"4km5" }, { "sim":485.0, @@ -448421,19 +450387,19 @@ }, { "sim":484.0, - "partner":"6y5d" + "partner":"6y5e" }, { "sim":484.0, - "partner":"6y5e" + "partner":"6y5d" }, { "sim":89.0, - "partner":"5eog" + "partner":"5eom" }, { "sim":89.0, - "partner":"5eom" + "partner":"5eog" }, { "sim":63.0, @@ -448551,111 +450517,111 @@ "subtitle":"Crystal structure of deep network hallucinated protein 0738_mod", "tags":[ "de novo protein", - "alpha-beta fold", - "machine learning" + "machine learning", + "alpha-beta fold" ], "keywords":[ - "alongside", - "background", - "distributions", - "129", - "thus", - "hallucinated", + "whether", "divergence", - "acid", - "crystallography", - "expressed", - "prediction", - "purified", - "methods", - "determined", - "sampling", - "sequences", - "synthetic", - "structure", + "genes", "escherichia", - "networks", - "trrosetta", - "predict", - "rich", - "novel", - "starting", - "consistent", + "unrelated", + "distance", + "methods", + "background", + "quite", + "inverted", + "information", + "three", + "points", + "acid", + "new", + "spectra", + "protein", "network", - "proteins", - "models", - "random", - "training", - "de", - "whether", - "carlo", + "maps", + "monte", + "neural", + "networks", + "novo", + "encoding", + "circular", "trained", - "yielded", - "used", + "expected", "27", + "two", + "purified", + "recent", + "using", + "captured", "occurring", + "deep", + "monodisperse", + "distributions", + "starting", + "thus", + "consistent", + "functions", + "input", + "matched", + "optimization", "folded", - "structures", - "naturally", - "three", - "native", - "circular", - "contribute", + "proteins", + "129", + "alongside", + "predict", + "sufficiently", "investigate", "obtained", - "considerable", - "expected", + "design", + "sampling", + "used", + "different", + "species", + "rich", + "prediction", + "carry", "amino", - "spectra", - "sufficiently", - "coli", - "generate", + "wide", + "trrosetta", "resulted", - "optimization", - "information", - "monte", - "functions", - "closely", - "points", - "spanning", - "design", - "distance", - "quite", - "using", - "progress", - "nmr", - "captured", - "recent", - "neural", - "maps", + "contrast", + "coli", + "predicted", "sequence", - "genes", - "featureless", - "input", - "optimizing", "range", - "predicted", - "averaged", - "encoding", + "hallucinated", + "models", + "naturally", + "sequences", + "space", "one", - "monodisperse", - "wide", - "novo", - "contrast", - "matched", - "carry", - "species", - "different", - "unrelated", - "two", - "inverted", - "protein", "distances", - "space", - "deep", - "dichroism", + "structures", "traditional", - "new" + "de", + "progress", + "training", + "expressed", + "contribute", + "structure", + "optimizing", + "synthetic", + "determined", + "closely", + "crystallography", + "nmr", + "spanning", + "random", + "yielded", + "considerable", + "native", + "dichroism", + "averaged", + "featureless", + "generate", + "novel", + "carlo" ], "release_date":"2021-12-29", "publication":"\"De novo protein design by deep network hallucination\", Nature, 600, 547-552", @@ -448720,19 +450686,19 @@ }, { "sim":51.0, - "partner":"5dns" + "partner":"5dn0" }, { "sim":51.0, - "partner":"5dn0" + "partner":"5dns" }, { "sim":51.0, - "partner":"5dzb" + "partner":"4yfo" }, { "sim":51.0, - "partner":"4yfo" + "partner":"5dzb" }, { "sim":51.0, @@ -448774,15 +450740,15 @@ }, { "sim":58.0, - "partner":"5bnq" + "partner":"3me2" }, { "sim":58.0, - "partner":"3me2" + "partner":"3me4" }, { "sim":58.0, - "partner":"3me4" + "partner":"5bnq" }, { "sim":58.0, @@ -448804,10 +450770,6 @@ "sim":57.0, "partner":"1t57" }, - { - "sim":57.0, - "partner":"3aio" - }, { "sim":57.0, "partner":"3aik" @@ -448824,6 +450786,10 @@ "sim":57.0, "partner":"3ain" }, + { + "sim":57.0, + "partner":"3aio" + }, { "sim":57.0, "partner":"3fvm" @@ -448936,10 +450902,6 @@ "sim":55.0, "partner":"2gee" }, - { - "sim":55.0, - "partner":"3l1u" - }, { "sim":55.0, "partner":"3l1v" @@ -448956,6 +450918,10 @@ "sim":55.0, "partner":"3esr" }, + { + "sim":55.0, + "partner":"3l1u" + }, { "sim":55.0, "partner":"6azq" @@ -448978,11 +450944,11 @@ }, { "sim":55.0, - "partner":"4rdh" + "partner":"4rdi" }, { "sim":55.0, - "partner":"4rdi" + "partner":"4rdh" }, { "sim":55.0, @@ -449020,10 +450986,6 @@ "sim":55.0, "partner":"5c2h" }, - { - "sim":55.0, - "partner":"3c1y" - }, { "sim":55.0, "partner":"3c1z" @@ -449048,6 +451010,10 @@ "sim":55.0, "partner":"4yxm" }, + { + "sim":55.0, + "partner":"3c1y" + }, { "sim":55.0, "partner":"6j38" @@ -449068,17 +451034,13 @@ "sim":55.0, "partner":"7lji" }, - { - "sim":55.0, - "partner":"3amu" - }, { "sim":55.0, "partner":"3amt" }, { "sim":55.0, - "partner":"2imc" + "partner":"3amu" }, { "sim":55.0, @@ -449104,6 +451066,10 @@ "sim":55.0, "partner":"2imb" }, + { + "sim":55.0, + "partner":"2imc" + }, { "sim":55.0, "partner":"4kuf" @@ -449128,10 +451094,6 @@ "sim":55.0, "partner":"4elc" }, - { - "sim":55.0, - "partner":"2cj9" - }, { "sim":55.0, "partner":"2cja" @@ -449144,6 +451106,10 @@ "sim":55.0, "partner":"2cjb" }, + { + "sim":55.0, + "partner":"2cj9" + }, { "sim":55.0, "partner":"5apn" @@ -449180,10 +451146,6 @@ "sim":54.0, "partner":"3zmd" }, - { - "sim":54.0, - "partner":"6a98" - }, { "sim":54.0, "partner":"6a99" @@ -449194,11 +451156,11 @@ }, { "sim":54.0, - "partner":"3x21" + "partner":"6a98" }, { "sim":54.0, - "partner":"4be6" + "partner":"3x21" }, { "sim":54.0, @@ -449214,11 +451176,11 @@ }, { "sim":54.0, - "partner":"3h26" + "partner":"4be6" }, { "sim":54.0, - "partner":"1twz" + "partner":"1tx0" }, { "sim":54.0, @@ -449228,10 +451190,6 @@ "sim":54.0, "partner":"4d8a" }, - { - "sim":54.0, - "partner":"1tx0" - }, { "sim":54.0, "partner":"1tx2" @@ -449346,15 +451304,15 @@ }, { "sim":54.0, - "partner":"6l1g" + "partner":"3h26" }, { "sim":54.0, - "partner":"4h2w" + "partner":"1twz" }, { "sim":54.0, - "partner":"3mey" + "partner":"6l1g" }, { "sim":54.0, @@ -449394,39 +451352,27 @@ }, { "sim":54.0, - "partner":"7ajm" - }, - { - "sim":54.0, - "partner":"7a4r" - }, - { - "sim":54.0, - "partner":"7ajs" - }, - { - "sim":54.0, - "partner":"7a52" + "partner":"4h2w" }, { "sim":54.0, - "partner":"7a53" + "partner":"3mey" }, { "sim":54.0, - "partner":"7ajw" + "partner":"7a4r" }, { "sim":54.0, - "partner":"7akb" + "partner":"7ajs" }, { "sim":54.0, - "partner":"7ajy" + "partner":"7a52" }, { "sim":54.0, - "partner":"7a5l" + "partner":"7ajm" }, { "sim":54.0, @@ -449488,17 +451434,33 @@ "sim":54.0, "partner":"7aka" }, + { + "sim":54.0, + "partner":"7a53" + }, { "sim":54.0, "partner":"7akl" }, { "sim":54.0, - "partner":"2o1t" + "partner":"7ajw" }, { "sim":54.0, - "partner":"6f47" + "partner":"7akb" + }, + { + "sim":54.0, + "partner":"7ajy" + }, + { + "sim":54.0, + "partner":"7a5l" + }, + { + "sim":54.0, + "partner":"2o1t" }, { "sim":54.0, @@ -449506,7 +451468,7 @@ }, { "sim":54.0, - "partner":"5kdn" + "partner":"6f47" }, { "sim":54.0, @@ -449516,6 +451478,10 @@ "sim":54.0, "partner":"5kdu" }, + { + "sim":54.0, + "partner":"5kdn" + }, { "sim":54.0, "partner":"4p2b" @@ -449540,10 +451506,6 @@ "sim":53.0, "partner":"6v4x" }, - { - "sim":53.0, - "partner":"5zrk" - }, { "sim":53.0, "partner":"5zrl" @@ -449572,6 +451534,10 @@ "sim":53.0, "partner":"5zri" }, + { + "sim":53.0, + "partner":"5zrk" + }, { "sim":53.0, "partner":"4yx2" @@ -449628,10 +451594,6 @@ "sim":53.0, "partner":"3sbc" }, - { - "sim":53.0, - "partner":"5wps" - }, { "sim":53.0, "partner":"5wpu" @@ -449664,6 +451626,10 @@ "sim":53.0, "partner":"5wpr" }, + { + "sim":53.0, + "partner":"5wps" + }, { "sim":53.0, "partner":"3c6h" @@ -449680,10 +451646,6 @@ "sim":53.0, "partner":"6kds" }, - { - "sim":53.0, - "partner":"4da6" - }, { "sim":53.0, "partner":"4da7" @@ -449738,7 +451700,7 @@ }, { "sim":53.0, - "partner":"5h5a" + "partner":"4da6" }, { "sim":53.0, @@ -449746,12 +451708,16 @@ }, { "sim":53.0, - "partner":"5tii" + "partner":"5h5a" }, { "sim":53.0, "partner":"5thq" }, + { + "sim":53.0, + "partner":"5tii" + }, { "sim":53.0, "partner":"2ihy" @@ -449778,19 +451744,19 @@ }, { "sim":53.0, - "partner":"6mql" + "partner":"6mqb" }, { "sim":53.0, - "partner":"6mq9" + "partner":"6mqk" }, { "sim":53.0, - "partner":"6mqb" + "partner":"6mql" }, { "sim":53.0, - "partner":"6mqk" + "partner":"6mq9" }, { "sim":53.0, @@ -449812,14 +451778,6 @@ "sim":53.0, "partner":"4xbz" }, - { - "sim":53.0, - "partner":"5glm" - }, - { - "sim":53.0, - "partner":"5gln" - }, { "sim":53.0, "partner":"5glo" @@ -449848,6 +451806,14 @@ "sim":53.0, "partner":"5gll" }, + { + "sim":53.0, + "partner":"5glm" + }, + { + "sim":53.0, + "partner":"5gln" + }, { "sim":53.0, "partner":"3rny" @@ -449888,10 +451854,6 @@ "sim":53.0, "partner":"3gxo" }, - { - "sim":53.0, - "partner":"5akd" - }, { "sim":53.0, "partner":"3gwz" @@ -449906,7 +451868,7 @@ }, { "sim":53.0, - "partner":"5hxu" + "partner":"5akd" }, { "sim":53.0, @@ -449920,6 +451882,10 @@ "sim":53.0, "partner":"5hwe" }, + { + "sim":53.0, + "partner":"5hxu" + }, { "sim":53.0, "partner":"4bko" @@ -450012,10 +451978,6 @@ "sim":53.0, "partner":"5m1e" }, - { - "sim":53.0, - "partner":"5klk" - }, { "sim":53.0, "partner":"5kll" @@ -450036,6 +451998,10 @@ "sim":53.0, "partner":"5kj5" }, + { + "sim":53.0, + "partner":"5klk" + }, { "sim":53.0, "partner":"3n6r" @@ -450104,10 +452070,6 @@ "sim":53.0, "partner":"5xrc" }, - { - "sim":53.0, - "partner":"7rpw" - }, { "sim":53.0, "partner":"2hiv" @@ -450124,6 +452086,10 @@ "sim":53.0, "partner":"7rpo" }, + { + "sim":53.0, + "partner":"7rpw" + }, { "sim":53.0, "partner":"5nz7" @@ -450140,10 +452106,6 @@ "sim":53.0, "partner":"5n0c" }, - { - "sim":53.0, - "partner":"6yt0" - }, { "sim":53.0, "partner":"4zhj" @@ -450160,6 +452122,10 @@ "sim":53.0, "partner":"6ytj" }, + { + "sim":53.0, + "partner":"6yt0" + }, { "sim":52.0, "partner":"2khj" @@ -450196,10 +452162,6 @@ "sim":52.0, "partner":"2vq9" }, - { - "sim":52.0, - "partner":"3rg6" - }, { "sim":52.0, "partner":"2wvw" @@ -450214,7 +452176,7 @@ }, { "sim":52.0, - "partner":"6suj" + "partner":"3rg6" }, { "sim":52.0, @@ -450222,11 +452184,11 @@ }, { "sim":52.0, - "partner":"3i93" + "partner":"6suj" }, { "sim":52.0, - "partner":"6ebc" + "partner":"3i93" }, { "sim":52.0, @@ -450240,6 +452202,10 @@ "sim":52.0, "partner":"6eb4" }, + { + "sim":52.0, + "partner":"6ebc" + }, { "sim":52.0, "partner":"5ect" @@ -450250,7 +452216,7 @@ }, { "sim":52.0, - "partner":"5edd" + "partner":"8p8o" }, { "sim":52.0, @@ -450284,10 +452250,6 @@ "sim":52.0, "partner":"3loj" }, - { - "sim":52.0, - "partner":"8p8o" - }, { "sim":52.0, "partner":"1sm8" @@ -450300,6 +452262,10 @@ "sim":52.0, "partner":"3hza" }, + { + "sim":52.0, + "partner":"5edd" + }, { "sim":52.0, "partner":"2b6b" @@ -450326,19 +452292,19 @@ }, { "sim":52.0, - "partner":"3th5" + "partner":"4gzl" }, { "sim":52.0, - "partner":"4c76" + "partner":"4gzm" }, { "sim":52.0, - "partner":"4gzl" + "partner":"3th5" }, { "sim":52.0, - "partner":"4gzm" + "partner":"4c76" }, { "sim":52.0, @@ -450370,15 +452336,15 @@ }, { "sim":52.0, - "partner":"5cvd" + "partner":"5cve" }, { "sim":52.0, - "partner":"5cve" + "partner":"6kdq" }, { "sim":52.0, - "partner":"6kdq" + "partner":"5cvd" }, { "sim":52.0, @@ -450418,15 +452384,15 @@ }, { "sim":52.0, - "partner":"2pzm" + "partner":"2pzk" }, { "sim":52.0, - "partner":"2pzk" + "partner":"2pzl" }, { "sim":52.0, - "partner":"2pzl" + "partner":"2pzm" }, { "sim":52.0, @@ -450478,23 +452444,19 @@ }, { "sim":52.0, - "partner":"6pi5" + "partner":"6pi6" }, { "sim":52.0, "partner":"6pii" }, - { - "sim":52.0, - "partner":"6pi6" - }, { "sim":52.0, "partner":"5v8y" }, { "sim":52.0, - "partner":"5jyf" + "partner":"6pi5" }, { "sim":52.0, @@ -450524,6 +452486,10 @@ "sim":52.0, "partner":"5jye" }, + { + "sim":52.0, + "partner":"5jyf" + }, { "sim":52.0, "partner":"4ilk" @@ -450580,17 +452546,13 @@ "sim":52.0, "partner":"6n85" }, - { - "sim":52.0, - "partner":"3wkr" - }, { "sim":52.0, "partner":"3wks" }, { "sim":52.0, - "partner":"4euh" + "partner":"3wkr" }, { "sim":52.0, @@ -450606,19 +452568,7 @@ }, { "sim":52.0, - "partner":"6p3v" - }, - { - "sim":52.0, - "partner":"6vur" - }, - { - "sim":52.0, - "partner":"6vus" - }, - { - "sim":52.0, - "partner":"6vut" + "partner":"4euh" }, { "sim":52.0, @@ -450642,19 +452592,19 @@ }, { "sim":52.0, - "partner":"5tvj" + "partner":"6vuz" }, { "sim":52.0, - "partner":"6b3t" + "partner":"6vv0" }, { "sim":52.0, - "partner":"6vuz" + "partner":"5tvj" }, { "sim":52.0, - "partner":"6vv0" + "partner":"6b3t" }, { "sim":52.0, @@ -450702,11 +452652,23 @@ }, { "sim":52.0, - "partner":"3zdr" + "partner":"6p3v" }, { "sim":52.0, - "partner":"5z8a" + "partner":"6vur" + }, + { + "sim":52.0, + "partner":"6vus" + }, + { + "sim":52.0, + "partner":"6vut" + }, + { + "sim":52.0, + "partner":"3zdr" }, { "sim":52.0, @@ -450716,6 +452678,10 @@ "sim":52.0, "partner":"5z83" }, + { + "sim":52.0, + "partner":"5z8a" + }, { "sim":52.0, "partner":"3deb" @@ -450730,15 +452696,15 @@ }, { "sim":52.0, - "partner":"5uno" + "partner":"5uoh" }, { "sim":52.0, - "partner":"5uoh" + "partner":"5ugq" }, { "sim":52.0, - "partner":"5ugq" + "partner":"5uno" }, { "sim":52.0, @@ -450762,15 +452728,15 @@ }, { "sim":52.0, - "partner":"5lj7" + "partner":"5lil" }, { "sim":52.0, - "partner":"5lil" + "partner":"5lj6" }, { "sim":52.0, - "partner":"5lj6" + "partner":"5lj7" }, { "sim":52.0, @@ -450874,15 +452840,15 @@ }, { "sim":52.0, - "partner":"6tsh" + "partner":"6tsk" }, { "sim":52.0, - "partner":"6tte" + "partner":"6tsh" }, { "sim":52.0, - "partner":"6tsk" + "partner":"6tte" }, { "sim":51.0, @@ -451002,11 +452968,11 @@ }, { "sim":51.0, - "partner":"5x3t" + "partner":"6cky" }, { "sim":51.0, - "partner":"6cky" + "partner":"5x3t" }, { "sim":51.0, @@ -451040,10 +453006,6 @@ "sim":51.0, "partner":"6c0z" }, - { - "sim":51.0, - "partner":"2vbq" - }, { "sim":51.0, "partner":"1s3z" @@ -451056,6 +453018,10 @@ "sim":51.0, "partner":"1s60" }, + { + "sim":51.0, + "partner":"2vbq" + }, { "sim":51.0, "partner":"2mux" @@ -451138,11 +453104,11 @@ }, { "sim":51.0, - "partner":"5k24" + "partner":"5k22" }, { "sim":51.0, - "partner":"5k22" + "partner":"5k24" }, { "sim":51.0, @@ -451150,11 +453116,11 @@ }, { "sim":51.0, - "partner":"4o8t" + "partner":"4o8l" }, { "sim":51.0, - "partner":"4o8l" + "partner":"4o8t" }, { "sim":51.0, @@ -451206,11 +453172,11 @@ }, { "sim":51.0, - "partner":"1wc6" + "partner":"1wc1" }, { "sim":51.0, - "partner":"1wc1" + "partner":"1wc6" }, { "sim":51.0, @@ -451218,23 +453184,23 @@ }, { "sim":51.0, - "partner":"4njh" + "partner":"4njj" }, { "sim":51.0, - "partner":"4nji" + "partner":"4njk" }, { "sim":51.0, - "partner":"4njj" + "partner":"4njg" }, { "sim":51.0, - "partner":"4njk" + "partner":"4njh" }, { "sim":51.0, - "partner":"4njg" + "partner":"4nji" }, { "sim":51.0, @@ -451250,11 +453216,11 @@ }, { "sim":51.0, - "partner":"2fz4" + "partner":"3x22" }, { "sim":51.0, - "partner":"3x22" + "partner":"2fz4" }, { "sim":51.0, @@ -451394,19 +453360,19 @@ }, { "sim":51.0, - "partner":"3nha" + "partner":"3nh6" }, { "sim":51.0, - "partner":"3nhb" + "partner":"3nh9" }, { "sim":51.0, - "partner":"3nh6" + "partner":"3nha" }, { "sim":51.0, - "partner":"3nh9" + "partner":"3nhb" }, { "sim":51.0, @@ -451460,14 +453426,6 @@ "sim":51.0, "partner":"3jrq" }, - { - "sim":51.0, - "partner":"2nq6" - }, - { - "sim":51.0, - "partner":"2nq7" - }, { "sim":51.0, "partner":"2b3k" @@ -451508,6 +453466,14 @@ "sim":51.0, "partner":"2gz5" }, + { + "sim":51.0, + "partner":"2nq6" + }, + { + "sim":51.0, + "partner":"2nq7" + }, { "sim":51.0, "partner":"5lor" @@ -451556,21 +453522,17 @@ "sim":51.0, "partner":"4u6s" }, - { - "sim":51.0, - "partner":"6sf5" - }, { "sim":51.0, "partner":"6sf4" }, { "sim":51.0, - "partner":"7kwm" + "partner":"6sf5" }, { "sim":51.0, - "partner":"5l9l" + "partner":"7kwm" }, { "sim":51.0, @@ -451592,6 +453554,10 @@ "sim":51.0, "partner":"5l9i" }, + { + "sim":51.0, + "partner":"5l9l" + }, { "sim":51.0, "partner":"6gpn" @@ -451702,27 +453668,27 @@ }, { "sim":51.0, - "partner":"6fm0" + "partner":"6fm3" }, { "sim":51.0, - "partner":"6rm2" + "partner":"6flf" }, { "sim":51.0, - "partner":"6fko" + "partner":"6fm0" }, { "sim":51.0, - "partner":"6fm1" + "partner":"6rm2" }, { "sim":51.0, - "partner":"6fm3" + "partner":"6fko" }, { "sim":51.0, - "partner":"6flf" + "partner":"6fm1" }, { "sim":51.0, @@ -451760,10 +453726,6 @@ "sim":51.0, "partner":"5kbz" }, - { - "sim":51.0, - "partner":"7azd" - }, { "sim":51.0, "partner":"7az5" @@ -451802,11 +453764,11 @@ }, { "sim":51.0, - "partner":"6c8v" + "partner":"7azd" }, { "sim":51.0, - "partner":"2y6r" + "partner":"6c8v" }, { "sim":51.0, @@ -451828,6 +453790,10 @@ "sim":51.0, "partner":"2y6q" }, + { + "sim":51.0, + "partner":"2y6r" + }, { "sim":51.0, "partner":"7jyb" @@ -451874,15 +453840,15 @@ }, { "sim":51.0, - "partner":"7cl7" + "partner":"6l69" }, { "sim":51.0, - "partner":"7cl8" + "partner":"7cl7" }, { "sim":51.0, - "partner":"6l69" + "partner":"7cl8" }, { "sim":51.0, @@ -451892,10 +453858,6 @@ "sim":51.0, "partner":"4doy" }, - { - "sim":51.0, - "partner":"4q6q" - }, { "sim":51.0, "partner":"4q6m" @@ -451914,7 +453876,7 @@ }, { "sim":51.0, - "partner":"7lr2" + "partner":"4q6q" }, { "sim":51.0, @@ -451928,6 +453890,10 @@ "sim":51.0, "partner":"5xwb" }, + { + "sim":51.0, + "partner":"7lr2" + }, { "sim":51.0, "partner":"6p7k" @@ -452108,10 +454074,6 @@ "sim":51.0, "partner":"2wys" }, - { - "sim":51.0, - "partner":"2r0p" - }, { "sim":51.0, "partner":"2r0c" @@ -452132,6 +454094,10 @@ "sim":51.0, "partner":"3ept" }, + { + "sim":51.0, + "partner":"2r0p" + }, { "sim":51.0, "partner":"5jjq" @@ -452154,11 +454120,11 @@ }, { "sim":51.0, - "partner":"5ess" + "partner":"5esd" }, { "sim":51.0, - "partner":"5esd" + "partner":"5ess" }, { "sim":51.0, @@ -452230,11 +454196,11 @@ }, { "sim":51.0, - "partner":"5faw" + "partner":"6vue" }, { "sim":51.0, - "partner":"6vue" + "partner":"5faw" }, { "sim":51.0, @@ -452248,10 +454214,6 @@ "sim":51.0, "partner":"6nd3" }, - { - "sim":51.0, - "partner":"5y1h" - }, { "sim":51.0, "partner":"5y1k" @@ -452296,6 +454258,10 @@ "sim":51.0, "partner":"5y3i" }, + { + "sim":51.0, + "partner":"5y1h" + }, { "sim":50.0, "partner":"4u39" @@ -452362,11 +454328,11 @@ }, { "sim":50.0, - "partner":"5ho3" + "partner":"5ho1" }, { "sim":50.0, - "partner":"5ho1" + "partner":"5ho3" }, { "sim":50.0, @@ -452486,15 +454452,15 @@ }, { "sim":50.0, - "partner":"2o4d" + "partner":"6vpe" }, { "sim":50.0, - "partner":"6vpe" + "partner":"6vli" }, { "sim":50.0, - "partner":"6vli" + "partner":"2o4d" }, { "sim":50.0, @@ -452516,10 +454482,6 @@ "sim":50.0, "partner":"2wh7" }, - { - "sim":50.0, - "partner":"4gzc" - }, { "sim":50.0, "partner":"4gzd" @@ -452538,31 +454500,11 @@ }, { "sim":50.0, - "partner":"4cec" - }, - { - "sim":50.0, - "partner":"4cgf" - }, - { - "sim":50.0, - "partner":"4chp" - }, - { - "sim":50.0, - "partner":"4cjt" - }, - { - "sim":50.0, - "partner":"3avi" - }, - { - "sim":50.0, - "partner":"4chq" + "partner":"4gzc" }, { "sim":50.0, - "partner":"4ovl" + "partner":"3av9" }, { "sim":50.0, @@ -452580,10 +454522,6 @@ "sim":50.0, "partner":"4cju" }, - { - "sim":50.0, - "partner":"3av9" - }, { "sim":50.0, "partner":"4cee" @@ -452848,6 +454786,34 @@ "sim":50.0, "partner":"4cjs" }, + { + "sim":50.0, + "partner":"4chp" + }, + { + "sim":50.0, + "partner":"4cec" + }, + { + "sim":50.0, + "partner":"4cgf" + }, + { + "sim":50.0, + "partner":"4cjt" + }, + { + "sim":50.0, + "partner":"3avi" + }, + { + "sim":50.0, + "partner":"4chq" + }, + { + "sim":50.0, + "partner":"4ovl" + }, { "sim":50.0, "partner":"3kx0" @@ -452910,11 +454876,11 @@ }, { "sim":50.0, - "partner":"3kwe" + "partner":"3kwd" }, { "sim":50.0, - "partner":"3kwd" + "partner":"3kwe" }, { "sim":50.0, @@ -452942,15 +454908,15 @@ }, { "sim":50.0, - "partner":"5n7o" + "partner":"6hry" }, { "sim":50.0, - "partner":"6hry" + "partner":"5n7o" }, { "sim":50.0, - "partner":"1dto" + "partner":"6hrz" }, { "sim":50.0, @@ -452958,15 +454924,15 @@ }, { "sim":50.0, - "partner":"6hrz" + "partner":"6hs0" }, { "sim":50.0, - "partner":"6hs0" + "partner":"6hs1" }, { "sim":50.0, - "partner":"6hs1" + "partner":"1dto" }, { "sim":50.0, @@ -452996,14 +454962,6 @@ "sim":50.0, "partner":"3uc9" }, - { - "sim":50.0, - "partner":"3nh1" - }, - { - "sim":50.0, - "partner":"3v9z" - }, { "sim":50.0, "partner":"3v9u" @@ -453056,6 +455014,14 @@ "sim":50.0, "partner":"3v9s" }, + { + "sim":50.0, + "partner":"3nh1" + }, + { + "sim":50.0, + "partner":"3v9z" + }, { "sim":50.0, "partner":"2qhs" @@ -453118,51 +455084,51 @@ }, { "sim":50.0, - "partner":"4yvk" + "partner":"6ihv" }, { "sim":50.0, - "partner":"6ihr" + "partner":"6ihw" }, { "sim":50.0, - "partner":"6iht" + "partner":"4yqd" }, { "sim":50.0, - "partner":"6ihu" + "partner":"3axz" }, { "sim":50.0, - "partner":"6ihv" + "partner":"4yvg" }, { "sim":50.0, - "partner":"6ihw" + "partner":"4yvh" }, { "sim":50.0, - "partner":"4yqd" + "partner":"4yvi" }, { "sim":50.0, - "partner":"3axz" + "partner":"4yvj" }, { "sim":50.0, - "partner":"4yvg" + "partner":"6ihr" }, { "sim":50.0, - "partner":"4yvh" + "partner":"4yvk" }, { "sim":50.0, - "partner":"4yvi" + "partner":"6iht" }, { "sim":50.0, - "partner":"4yvj" + "partner":"6ihu" }, { "sim":50.0, @@ -453176,10 +455142,6 @@ "sim":50.0, "partner":"5lom" }, - { - "sim":50.0, - "partner":"4m7t" - }, { "sim":50.0, "partner":"5t65" @@ -453192,6 +455154,10 @@ "sim":50.0, "partner":"5t7m" }, + { + "sim":50.0, + "partner":"4m7t" + }, { "sim":50.0, "partner":"5ltv" @@ -453226,15 +455192,15 @@ }, { "sim":50.0, - "partner":"6fcn" + "partner":"6ypa" }, { "sim":50.0, - "partner":"6ypa" + "partner":"6fcm" }, { "sim":50.0, - "partner":"6fcm" + "partner":"6fcn" }, { "sim":50.0, @@ -453336,17 +455302,13 @@ "sim":50.0, "partner":"4ats" }, - { - "sim":50.0, - "partner":"6iqs" - }, { "sim":50.0, "partner":"6iqq" }, { "sim":50.0, - "partner":"4rtl" + "partner":"6iqs" }, { "sim":50.0, @@ -453390,12 +455352,16 @@ }, { "sim":50.0, - "partner":"3ta4" + "partner":"4rtl" }, { "sim":50.0, "partner":"3t9w" }, + { + "sim":50.0, + "partner":"3ta4" + }, { "sim":50.0, "partner":"3h85" @@ -453416,10 +455382,6 @@ "sim":50.0, "partner":"5xgf" }, - { - "sim":50.0, - "partner":"3ws7" - }, { "sim":50.0, "partner":"5xvh" @@ -453434,7 +455396,7 @@ }, { "sim":50.0, - "partner":"5uto" + "partner":"3ws7" }, { "sim":50.0, @@ -453442,11 +455404,11 @@ }, { "sim":50.0, - "partner":"2vf2" + "partner":"5uto" }, { "sim":50.0, - "partner":"7ag7" + "partner":"2vf2" }, { "sim":50.0, @@ -453454,11 +455416,11 @@ }, { "sim":50.0, - "partner":"3u3j" + "partner":"7ag7" }, { "sim":50.0, - "partner":"3u3r" + "partner":"3u3j" }, { "sim":50.0, @@ -453476,6 +455438,10 @@ "sim":50.0, "partner":"3u3o" }, + { + "sim":50.0, + "partner":"3u3r" + }, { "sim":50.0, "partner":"7c0q" @@ -453570,23 +455536,23 @@ }, { "sim":50.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":50.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":50.0, - "partner":"3tm8" + "partner":"6unx" }, { "sim":50.0, - "partner":"3tmb" + "partner":"3tmc" }, { "sim":50.0, - "partner":"6unx" + "partner":"3tmd" }, { "sim":50.0, @@ -453600,10 +455566,6 @@ "sim":50.0, "partner":"2jgv" }, - { - "sim":50.0, - "partner":"6lcn" - }, { "sim":50.0, "partner":"1w2n" @@ -453620,6 +455582,10 @@ "sim":50.0, "partner":"1w2a" }, + { + "sim":50.0, + "partner":"6lcn" + }, { "sim":50.0, "partner":"5um2" @@ -453648,25 +455614,17 @@ "sim":50.0, "partner":"5czl" }, - { - "sim":50.0, - "partner":"6q4x" - }, - { - "sim":50.0, - "partner":"6q4y" - }, { "sim":50.0, "partner":"6q4z" }, { "sim":50.0, - "partner":"5gg5" + "partner":"6q4x" }, { "sim":50.0, - "partner":"5xd1" + "partner":"6q4y" }, { "sim":50.0, @@ -453682,27 +455640,27 @@ }, { "sim":50.0, - "partner":"5gg7" + "partner":"6m6y" }, { "sim":50.0, - "partner":"5xd4" + "partner":"5gg7" }, { "sim":50.0, - "partner":"5xd5" + "partner":"5xd4" }, { "sim":50.0, - "partner":"6m6y" + "partner":"6m65" }, { "sim":50.0, - "partner":"5gg8" + "partner":"5xd5" }, { "sim":50.0, - "partner":"6m65" + "partner":"5gg8" }, { "sim":50.0, @@ -453734,12 +455692,20 @@ }, { "sim":50.0, - "partner":"6vwr" + "partner":"5gg5" + }, + { + "sim":50.0, + "partner":"5xd1" }, { "sim":50.0, "partner":"6vwq" }, + { + "sim":50.0, + "partner":"6vwr" + }, { "sim":50.0, "partner":"6jtz" @@ -453830,7 +455796,7 @@ }, { "sim":50.0, - "partner":"6kjh" + "partner":"6y9d" }, { "sim":50.0, @@ -453838,47 +455804,47 @@ }, { "sim":50.0, - "partner":"6y8j" + "partner":"2qap" }, { "sim":50.0, - "partner":"6y9c" + "partner":"6kjp" }, { "sim":50.0, - "partner":"6y9d" + "partner":"6kjq" }, { "sim":50.0, - "partner":"6kjj" + "partner":"6kjr" }, { "sim":50.0, - "partner":"2qap" + "partner":"6kjt" }, { "sim":50.0, - "partner":"6kjp" + "partner":"6y8s" }, { "sim":50.0, - "partner":"6kjq" + "partner":"2qdg" }, { "sim":50.0, - "partner":"6kjr" + "partner":"6kjh" }, { "sim":50.0, - "partner":"6kjt" + "partner":"6y8j" }, { "sim":50.0, - "partner":"6y8s" + "partner":"6y9c" }, { "sim":50.0, - "partner":"2qdg" + "partner":"6kjj" }, { "sim":50.0, @@ -453948,10 +455914,6 @@ "sim":50.0, "partner":"4k8g" }, - { - "sim":50.0, - "partner":"5cu7" - }, { "sim":50.0, "partner":"4fdt" @@ -453964,6 +455926,10 @@ "sim":50.0, "partner":"5cx4" }, + { + "sim":50.0, + "partner":"5cu7" + }, { "sim":50.0, "partner":"2alm" @@ -453986,23 +455952,23 @@ }, { "sim":50.0, - "partner":"6mp7" + "partner":"6moy" }, { "sim":50.0, - "partner":"6mpa" + "partner":"6mpc" }, { "sim":50.0, - "partner":"6moy" + "partner":"6mp2" }, { "sim":50.0, - "partner":"6mpc" + "partner":"6mp7" }, { "sim":50.0, - "partner":"6mp2" + "partner":"6mpa" }, { "sim":50.0, @@ -454028,10 +455994,6 @@ "sim":50.0, "partner":"3zlh" }, - { - "sim":50.0, - "partner":"2r98" - }, { "sim":50.0, "partner":"2r8v" @@ -454054,15 +456016,15 @@ }, { "sim":50.0, - "partner":"3nmz" + "partner":"2r98" }, { "sim":50.0, - "partner":"4il0" + "partner":"3nmz" }, { "sim":50.0, - "partner":"3hzz" + "partner":"4il0" }, { "sim":50.0, @@ -454070,11 +456032,7 @@ }, { "sim":50.0, - "partner":"6mlh" - }, - { - "sim":50.0, - "partner":"6mlw" + "partner":"3hzz" }, { "sim":50.0, @@ -454100,6 +456058,14 @@ "sim":50.0, "partner":"6mlf" }, + { + "sim":50.0, + "partner":"6mlh" + }, + { + "sim":50.0, + "partner":"6mlw" + }, { "sim":50.0, "partner":"7cys" @@ -454172,10 +456138,6 @@ "sim":50.0, "partner":"3qfb" }, - { - "sim":50.0, - "partner":"6bzn" - }, { "sim":50.0, "partner":"6bzz" @@ -454196,6 +456158,10 @@ "sim":50.0, "partner":"6bzi" }, + { + "sim":50.0, + "partner":"6bzn" + }, { "sim":50.0, "partner":"4k2x" @@ -454228,10 +456194,6 @@ "sim":50.0, "partner":"5kd5" }, - { - "sim":50.0, - "partner":"2q5l" - }, { "sim":50.0, "partner":"2q5o" @@ -454250,15 +456212,15 @@ }, { "sim":50.0, - "partner":"3bdl" + "partner":"2q5l" }, { "sim":50.0, - "partner":"6j1f" + "partner":"3bdl" }, { "sim":50.0, - "partner":"6j1e" + "partner":"6j1f" }, { "sim":50.0, @@ -454280,6 +456242,10 @@ "sim":50.0, "partner":"6j0p" }, + { + "sim":50.0, + "partner":"6j1e" + }, { "sim":50.0, "partner":"6dqw" @@ -454314,15 +456280,15 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"6edz" }, { "sim":50.0, - "partner":"6edz" + "partner":"6ee1" }, { "sim":50.0, - "partner":"6ee1" + "partner":"6edw" }, { "sim":50.0, @@ -454334,35 +456300,35 @@ }, { "sim":50.0, - "partner":"3ahc" + "partner":"3ahf" }, { "sim":50.0, - "partner":"3ahd" + "partner":"3ahg" }, { "sim":50.0, - "partner":"3ahe" + "partner":"3ahh" }, { "sim":50.0, - "partner":"3ahf" + "partner":"3ahi" }, { "sim":50.0, - "partner":"3ahg" + "partner":"3ahj" }, { "sim":50.0, - "partner":"3ahh" + "partner":"3ahc" }, { "sim":50.0, - "partner":"3ahi" + "partner":"3ahd" }, { "sim":50.0, - "partner":"3ahj" + "partner":"3ahe" }, { "sim":50.0, @@ -454496,107 +456462,107 @@ "de novo protein" ], "keywords":[ - "alongside", - "background", - "distributions", - "129", - "thus", - "hallucinated", + "whether", "divergence", - "acid", - "crystallography", - "expressed", - "prediction", - "purified", - "methods", - "determined", - "sampling", - "sequences", - "synthetic", - "structure", + "genes", "escherichia", - "networks", - "trrosetta", - "predict", - "rich", - "novel", - "starting", - "consistent", + "unrelated", + "distance", + "methods", + "background", + "quite", + "inverted", + "information", + "three", + "points", + "acid", + "new", + "spectra", + "protein", "network", - "proteins", - "models", - "random", - "training", - "de", - "whether", - "carlo", + "maps", + "monte", + "neural", + "networks", + "novo", + "encoding", + "circular", "trained", - "yielded", - "used", + "expected", "27", + "two", + "purified", + "recent", + "using", + "captured", "occurring", + "deep", + "monodisperse", + "distributions", + "starting", + "thus", + "consistent", + "functions", + "input", + "matched", + "optimization", "folded", - "structures", - "naturally", - "three", - "native", - "circular", - "contribute", + "proteins", + "129", + "alongside", + "predict", + "sufficiently", "investigate", "obtained", - "considerable", - "expected", + "design", + "sampling", + "used", + "different", + "species", + "rich", + "prediction", + "carry", "amino", - "spectra", - "sufficiently", - "coli", - "generate", + "wide", + "trrosetta", "resulted", - "optimization", - "information", - "monte", - "functions", - "closely", - "points", - "spanning", - "design", - "distance", - "quite", - "using", - "progress", - "nmr", - "captured", - "recent", - "neural", - "maps", + "contrast", + "coli", + "predicted", "sequence", - "genes", - "featureless", - "input", - "optimizing", "range", - "predicted", - "averaged", - "encoding", + "hallucinated", + "models", + "naturally", + "sequences", + "space", "one", - "monodisperse", - "wide", - "novo", - "contrast", - "matched", - "carry", - "species", - "different", - "unrelated", - "two", - "inverted", - "protein", "distances", - "space", - "deep", - "dichroism", + "structures", "traditional", - "new" + "de", + "progress", + "training", + "expressed", + "contribute", + "structure", + "optimizing", + "synthetic", + "determined", + "closely", + "crystallography", + "nmr", + "spanning", + "random", + "yielded", + "considerable", + "native", + "dichroism", + "averaged", + "featureless", + "generate", + "novel", + "carlo" ], "release_date":"2021-12-15", "publication":"\"De novo protein design by deep network hallucination\", Nature, 600, 547-552", @@ -454712,67 +456678,67 @@ "tim-barrel" ], "keywords":[ - "priors", - "without", - "data", - "demonstrate", - "produces", - "designs", - "excellent", - "directly", - "network", - "guide", - "models", - "entirely", - "generalizability", - "training", - "evaluate", - "stable", - "de", - "rational", - "novo", - "topologies", - "problems", - "method", - "tractability", - "seen", - "enormous", - "functions", - "agreement", + "learned", + "task", + "central", "producing", - "two", - "experimentally", - "crystal", "engineering", - "central", - "effort", - "scaffold", - "show", + "models", "design", - "task", - "model", "sequences", + "problems", + "energy", + "capability", "onto", - "gone", + "development", + "backbones", + "show", + "nearly", "structures", - "protein", + "de", + "effort", + "rational", + "agreement", + "training", + "experimentally", + "without", + "structure", + "novel", + "gone", + "generalizability", + "functions", + "model", + "seen", "findings", - "development", + "protein", + "network", + "topologies", + "automate", "neural", - "learned", - "sequence", - "structure", + "produces", + "silico", + "enormous", + "evaluate", + "priors", + "entirely", + "novo", + "demonstrate", "native", - "energy", + "scaffold", + "sequence", + "guide", "generalizes", - "automate", - "silico", - "nearly", + "excellent", + "two", + "data", + "crystal", + "stable", + "tractability", + "designs", + "method", + "investigate", "deep", - "backbones", - "novel", - "capability", - "investigate" + "directly" ], "release_date":"2022-01-19", "publication":"\"Protein sequence design with a learned potential\", Nat Commun, 13, 746-746", @@ -454829,11 +456795,11 @@ }, { "sim":142.0, - "partner":"7ot7" + "partner":"7osu" }, { "sim":142.0, - "partner":"7osu" + "partner":"7ot7" }, { "sim":142.0, @@ -454952,67 +456918,67 @@ "tim-barrel" ], "keywords":[ - "priors", - "without", - "data", - "demonstrate", - "produces", - "designs", - "excellent", - "directly", - "network", - "guide", - "models", - "entirely", - "generalizability", - "training", - "evaluate", - "stable", - "de", - "rational", - "novo", - "topologies", - "problems", - "method", - "tractability", - "seen", - "enormous", - "functions", - "agreement", + "learned", + "task", + "central", "producing", - "two", - "experimentally", - "crystal", "engineering", - "central", - "effort", - "scaffold", - "show", + "models", "design", - "task", - "model", "sequences", + "problems", + "energy", + "capability", "onto", - "gone", + "development", + "backbones", + "show", + "nearly", "structures", - "protein", + "de", + "effort", + "rational", + "agreement", + "training", + "experimentally", + "without", + "structure", + "novel", + "gone", + "generalizability", + "functions", + "model", + "seen", "findings", - "development", + "protein", + "network", + "topologies", + "automate", "neural", - "learned", - "sequence", - "structure", + "produces", + "silico", + "enormous", + "evaluate", + "priors", + "entirely", + "novo", + "demonstrate", "native", - "energy", + "scaffold", + "sequence", + "guide", "generalizes", - "automate", - "silico", - "nearly", + "excellent", + "two", + "data", + "crystal", + "stable", + "tractability", + "designs", + "method", + "investigate", "deep", - "backbones", - "novel", - "capability", - "investigate" + "directly" ], "release_date":"2022-01-19", "publication":"\"Protein sequence design with a learned potential\", Nat Commun, 13, 746-746", @@ -455057,19 +457023,19 @@ }, { "sim":130.0, - "partner":"7ot7" + "partner":"7osu" }, { "sim":130.0, - "partner":"6yqy" + "partner":"7ot7" }, { "sim":130.0, - "partner":"7osu" + "partner":"5bvl" }, { "sim":130.0, - "partner":"5bvl" + "partner":"6yqy" }, { "sim":122.0, @@ -455221,79 +457187,79 @@ ], "subtitle":"Structure of de novo designed beta sheet heterodimer lhd29a53\/b53", "tags":[ - "beta-sheet", "de novo protein", - "heterodimer", - "de novo design" + "beta-sheet", + "de novo design", + "heterodimer" ], "keywords":[ - "linearly", - "exchange", - "interfaces", - "reconfigure", - "general", - "demonstrate", - "designs", - "\u03b2", - "closed", - "undergo", - "models", + "asymmetric", "play", - "reversible", - "approach", - "components", + "central", + "heterodimers", + "designing", + "models", + "design", + "interfaces", + "association", "must", - "complexes", - "also", - "use", "multiprotein", - "behaved", - "stable", - "generate", - "wide", - "asymmetric", - "challenge", - "close", - "route", - "rapidly", - "rings", - "roles", - "enable", + "provides", + "soluble", + "complexes", "well", - "hub", - "isolation", + "biology", + "behaved", + "structures", + "closed", + "reconfigurable", "different", + "roles", "subunit", + "\u03b2", "mixing", - "crystal", - "heterodimers", - "six", + "route", + "rapidly", + "branched", + "also", + "reversible", + "assembled", + "cyclic", + "protein", + "implicit", + "readily", "folded", - "assemble", - "central", - "provides", - "design", + "six", + "reconfigure", + "wide", + "approach", + "linearly", + "enable", + "use", + "close", + "isolation", "arranged", - "structures", - "assembled", - "soluble", + "general", "upon", - "branched", - "present", - "reconfigurable", - "protein", + "demonstrate", "negative", + "exchange", + "components", + "systems", + "contain", + "rings", "variety", - "association", + "present", + "hub", + "crystal", + "stable", + "assemble", "construct", - "designing", - "readily", - "biology", + "challenge", + "designs", "computational", - "implicit", - "systems", - "cyclic", - "contain" + "generate", + "undergo" ], "release_date":"2022-01-19", "publication":"\"Reconfigurable asymmetric protein assemblies through implicit negative design\", Science, 375, eabj7662-eabj7662", @@ -455470,79 +457436,79 @@ ], "subtitle":"Structure of de novo designed beta sheet heterodimer lhd101a53\/b4", "tags":[ - "beta-sheet", "de novo protein", - "heterodimer", - "de novo design" + "beta-sheet", + "de novo design", + "heterodimer" ], "keywords":[ - "linearly", - "exchange", - "interfaces", - "reconfigure", - "general", - "demonstrate", - "designs", - "\u03b2", - "closed", - "undergo", - "models", + "asymmetric", "play", - "reversible", - "approach", - "components", + "central", + "heterodimers", + "designing", + "models", + "design", + "interfaces", + "association", "must", - "complexes", - "also", - "use", "multiprotein", - "behaved", - "stable", - "generate", - "wide", - "asymmetric", - "challenge", - "close", - "route", - "rapidly", - "rings", - "roles", - "enable", + "provides", + "soluble", + "complexes", "well", - "hub", - "isolation", + "biology", + "behaved", + "structures", + "closed", + "reconfigurable", "different", + "roles", "subunit", + "\u03b2", "mixing", - "crystal", - "heterodimers", - "six", + "route", + "rapidly", + "branched", + "also", + "reversible", + "assembled", + "cyclic", + "protein", + "implicit", + "readily", "folded", - "assemble", - "central", - "provides", - "design", + "six", + "reconfigure", + "wide", + "approach", + "linearly", + "enable", + "use", + "close", + "isolation", "arranged", - "structures", - "assembled", - "soluble", + "general", "upon", - "branched", - "present", - "reconfigurable", - "protein", + "demonstrate", "negative", + "exchange", + "components", + "systems", + "contain", + "rings", "variety", - "association", + "present", + "hub", + "crystal", + "stable", + "assemble", "construct", - "designing", - "readily", - "biology", + "challenge", + "designs", "computational", - "implicit", - "systems", - "cyclic", - "contain" + "generate", + "undergo" ], "release_date":"2022-01-19", "publication":"\"Reconfigurable asymmetric protein assemblies through implicit negative design\", Science, 375, eabj7662-eabj7662", @@ -455607,11 +457573,11 @@ }, { "sim":54.0, - "partner":"7udm" + "partner":"7udn" }, { "sim":54.0, - "partner":"7udn" + "partner":"7udm" }, { "sim":210.0, @@ -455827,106 +457793,106 @@ ], "subtitle":"Crystal structure of a de novo-designed mini-protein targeting fgfr", "tags":[ - "binder", - "de novo protein" + "de novo protein", + "binder" ], "keywords":[ + "hyperstable", + "half", + "experimental", "complexes", - "modes", - "challenge", - "search", - "broad", - "shapes", - "provide", - "current", - "smaller", - "crystal", - "target", - "applicability", - "bind", - "interactions", - "structure", - "therapeutic", - "general", - "proteins", - "models", - "enables", - "hundreds", - "thousands", - "de", - "point", - "remains", - "targeted", - "binders", + "information", + "intensifies", + "million", + "protein", + "binding", + "following", "site", - "picomolar", + "general", + "novo", + "demonstrate", "match", - "feedback", - "nanomolar", - "structures", - "improvements", - "solution", + "vast", + "variety", + "succeeded", + "applications", + "region", + "crystal", "corresponding", - "65", - "mutants", + "using", + "enables", "shows", "nearly", - "properties", - "data", - "following", - "amino", - "guide", - "detailed", - "exploration", - "optimization", - "acids", - "information", - "method", - "limitations", "interest", - "closely", - "region", + "modes", + "selected", "specific", - "12", - "design", + "targets", + "vicinity", + "optimization", + "bind", + "approach", + "proteins", + "sites", + "mutants", "characterization", - "using", - "applications", + "broad", + "improvements", + "shapes", + "nanomolar", + "computational", + "applicability", "surface", - "describe", - "promising", - "selected", - "sites", + "12", + "design", "diverse", - "demonstrate", - "designs", - "approach", - "novo", - "wide", - "succeeded", - "experimental", - "half", - "vicinity", + "binders", + "65", + "current", + "thousands", + "possible", "different", - "intensifies", - "strengths", - "affinities", - "problem", - "protein", - "targets", - "vast", + "properties", + "therapeutic", + "point", + "amino", + "wide", + "solution", + "promising", + "hundreds", + "describe", + "method", + "search", + "models", "space", - "variety", + "strengths", + "targeted", + "structures", + "de", + "feedback", "solving", - "hyperstable", - "understanding", - "computational", - "diagnostic", - "million", + "detailed", + "remains", + "structure", + "provide", + "closely", + "target", "starts", - "possible", - "binding", + "exploration", "biophysical", + "interactions", + "understanding", + "smaller", + "guide", + "acids", + "picomolar", + "diagnostic", + "data", + "problem", + "limitations", + "challenge", + "affinities", + "designs", "five" ], "release_date":"2022-04-06", @@ -456043,79 +458009,79 @@ "biosynthetic protein" ], "keywords":[ - "impact", - "retrotransposition", - "sites", - "domain", - "modification", - "demonstrate", - "evolution", - "overall", - "relating", - "one", - "directly", - "long", - "proteins", - "genetic", - "play", - "solved", - "thus", - "similar", - "metal", - "human", - "pb", - "peptide", - "1", - "crystallized", "designed", - "line1", + "play", "open", - "presence", - "influence", + "relating", + "grcs", + "shows", + "retrotransposition", + "role", + "metal", + "one", + "structural", + "modification", "reading", - "two", + "crystallized", "implicated", - "nuclear", - "binds", - "cys", - "mobile", - "3", - "preorganized", - "frequency", - "ii", - "comparison", - "model", "metals", - "grcs", - "mimic", - "significant", - "lead", - "numerous", - "protein", - "suggested", - "frame", - "orf1p", - "interspersed", - "l16cl23c", - "propose", - "exposure", "interior", - "essential", + "3", + "domain", + "presence", + "heavy", + "exposure", + "influence", + "directly", + "thus", + "overall", "structure", - "showed", - "function", - "encoded", + "lead", + "mimic", + "frame", "parameters", + "pb", + "model", "recently", - "could", + "mobile", + "impact", + "protein", + "propose", + "function", "diseases", + "proteins", "layers", - "shows", - "role", - "heavy", - "element", + "line1", + "orf1p", "binding", - "structural" + "sites", + "l16cl23c", + "showed", + "cys", + "essential", + "frequency", + "demonstrate", + "interspersed", + "solved", + "genetic", + "suggested", + "preorganized", + "numerous", + "two", + "evolution", + "nuclear", + "ii", + "binds", + "peptide", + "human", + "long", + "element", + "similar", + "1", + "encoded", + "could", + "comparison", + "significant" ], "release_date":"2022-06-01", "publication":"\"Open Reading Frame 1 Protein of the Human Long Interspersed Nuclear Element 1 Retrotransposon Binds Multiple Equivalents of Lead\", J.Am.Chem.Soc., 143, 15271-15278", @@ -456168,11 +458134,11 @@ }, { "sim":65.0, - "partner":"6egp" + "partner":"5kb2" }, { "sim":65.0, - "partner":"5kb2" + "partner":"6egp" }, { "sim":64.0, @@ -456188,7 +458154,7 @@ }, { "sim":51.0, - "partner":"5u9u" + "partner":"5u9t" }, { "sim":51.0, @@ -456196,7 +458162,7 @@ }, { "sim":51.0, - "partner":"5u9t" + "partner":"5u9u" } ], "seq_thr_sim_natural":[ @@ -456321,88 +458287,88 @@ ], "subtitle":"Crystal structure of a de novo three-stranded coiled coil peptide containing trigonal pyrmidal pb(ii) complexes in the dual tris-thiolate site", "tags":[ - "trigonal pyramidal lead complexes", "3scc", - "desinged protein", + "trigonal pyramidal lead complexes", + "biosynthetic protein", "de novo protein", - "three-stranded coiled coil", + "desinged protein", "heavy metal sites in protein", - "biosynthetic protein" + "three-stranded coiled coil" ], "keywords":[ - "impact", - "retrotransposition", - "sites", - "domain", - "modification", - "demonstrate", - "evolution", - "overall", - "relating", - "one", - "directly", - "long", - "proteins", - "genetic", - "play", - "solved", - "thus", - "similar", - "metal", - "human", - "pb", - "peptide", - "1", - "crystallized", "designed", - "line1", + "play", "open", - "presence", - "influence", + "relating", + "grcs", + "shows", + "retrotransposition", + "role", + "metal", + "one", + "structural", + "modification", "reading", - "two", + "crystallized", "implicated", - "nuclear", - "binds", - "cys", - "mobile", - "3", - "preorganized", - "frequency", - "ii", - "comparison", - "model", "metals", - "grcs", - "mimic", - "significant", - "lead", - "numerous", - "protein", - "suggested", - "frame", - "orf1p", - "interspersed", - "l16cl23c", - "propose", - "exposure", "interior", - "essential", + "3", + "domain", + "presence", + "heavy", + "exposure", + "influence", + "directly", + "thus", + "overall", "structure", - "showed", - "function", - "encoded", + "lead", + "mimic", + "frame", "parameters", + "pb", + "model", "recently", - "could", + "mobile", + "impact", + "protein", + "propose", + "function", "diseases", + "proteins", "layers", - "shows", - "role", - "heavy", - "element", + "line1", + "orf1p", "binding", - "structural" + "sites", + "l16cl23c", + "showed", + "cys", + "essential", + "frequency", + "demonstrate", + "interspersed", + "solved", + "genetic", + "suggested", + "preorganized", + "numerous", + "two", + "evolution", + "nuclear", + "ii", + "binds", + "peptide", + "human", + "long", + "element", + "similar", + "1", + "encoded", + "could", + "comparison", + "significant" ], "release_date":"2022-06-01", "publication":"\"Open Reading Frame 1 Protein of the Human Long Interspersed Nuclear Element 1 Retrotransposon Binds Multiple Equivalents of Lead\", J.Am.Chem.Soc., 143, 15271-15278", @@ -456455,11 +458421,11 @@ }, { "sim":65.0, - "partner":"6egp" + "partner":"5kb2" }, { "sim":65.0, - "partner":"5kb2" + "partner":"6egp" }, { "sim":64.0, @@ -456475,7 +458441,7 @@ }, { "sim":51.0, - "partner":"5u9u" + "partner":"5u9t" }, { "sim":51.0, @@ -456483,7 +458449,7 @@ }, { "sim":51.0, - "partner":"5u9t" + "partner":"5u9u" } ], "seq_thr_sim_natural":[ @@ -456733,106 +458699,106 @@ ], "subtitle":"Trka ecd complex with designed miniprotein ligand", "tags":[ - "complex", - "de novo protein" + "de novo protein", + "complex" ], "keywords":[ + "hyperstable", + "half", + "experimental", "complexes", - "modes", - "challenge", - "search", - "broad", - "shapes", - "provide", - "current", - "smaller", - "crystal", - "target", - "applicability", - "bind", - "interactions", - "structure", - "therapeutic", - "general", - "proteins", - "models", - "enables", - "hundreds", - "thousands", - "de", - "point", - "remains", - "targeted", - "binders", + "information", + "intensifies", + "million", + "protein", + "binding", + "following", "site", - "picomolar", + "general", + "novo", + "demonstrate", "match", - "feedback", - "nanomolar", - "structures", - "improvements", - "solution", + "vast", + "variety", + "succeeded", + "applications", + "region", + "crystal", "corresponding", - "65", - "mutants", + "using", + "enables", "shows", "nearly", - "properties", - "data", - "following", - "amino", - "guide", - "detailed", - "exploration", - "optimization", - "acids", - "information", - "method", - "limitations", "interest", - "closely", - "region", + "modes", + "selected", "specific", - "12", - "design", + "targets", + "vicinity", + "optimization", + "bind", + "approach", + "proteins", + "sites", + "mutants", "characterization", - "using", - "applications", + "broad", + "improvements", + "shapes", + "nanomolar", + "computational", + "applicability", "surface", - "describe", - "promising", - "selected", - "sites", + "12", + "design", "diverse", - "demonstrate", - "designs", - "approach", - "novo", - "wide", - "succeeded", - "experimental", - "half", - "vicinity", + "binders", + "65", + "current", + "thousands", + "possible", "different", - "intensifies", - "strengths", - "affinities", - "problem", - "protein", - "targets", - "vast", + "properties", + "therapeutic", + "point", + "amino", + "wide", + "solution", + "promising", + "hundreds", + "describe", + "method", + "search", + "models", "space", - "variety", + "strengths", + "targeted", + "structures", + "de", + "feedback", "solving", - "hyperstable", - "understanding", - "computational", - "diagnostic", - "million", + "detailed", + "remains", + "structure", + "provide", + "closely", + "target", "starts", - "possible", - "binding", + "exploration", "biophysical", + "interactions", + "understanding", + "smaller", + "guide", + "acids", + "picomolar", + "diagnostic", + "data", + "problem", + "limitations", + "challenge", + "affinities", + "designs", "five" ], "release_date":"2022-04-20", @@ -456881,7 +458847,7 @@ }, "seq_max_sim_natural":{ "sim":46.0, - "partner":"7jzm" + "partner":"7jzn" }, "struct_max_sim_designed":{ "sim":0.8147000074, @@ -456989,87 +458955,87 @@ ], "subtitle":"An octameric barrel state of a de novo coiled-coil assembly: cc-type2-(laid)4-i24a", "tags":[ + "homomeric assembly", "de novo protein", "coiled coil", - "homomeric assembly", "synthetic peptide" ], "keywords":[ - "diverse", - "fluorimetric", - "displacement", - "drink", - "many", - "causes", - "channels", - "differential", - "chemistries", - "models", + "designed", "diagnostically", + "complex", + "alternative", + "central", + "mammalian", + "models", + "taste", + "coupled", + "challenging", + "fingerprints", + "many", + "drink", + "displacement", "receptors", - "use", - "patterns", - "hundreds", - "barrels", + "show", + "smell", + "diverse", + "accommodate", + "used", "de", - "novo", - "analytes", - "relate", - "sizes", - "identify", - "place", - "peptides", - "designed", - "senses", + "discriminates", + "computationally", "\u03b1hbs", - "challenging", + "attempts", + "altered", + "mixtures", + "biological", + "differential", + "potential", + "sizes", + "sense", + "fluorimetric", + "synthetic", + "mimic", + "causes", "samples", + "provide", + "dyes", "resulting", - "small", - "employ", - "used", - "taste", + "relate", + "place", + "various", "relevant", - "shapes", - "provide", - "robust", + "analytes", "vary", - "biomolecules", - "smell", - "system", - "fluorophore", - "sensors", - "potential", - "central", + "patterns", "chemically", - "show", + "binding", + "biomolecules", + "train", + "molecules", + "use", + "identify", "sensing", - "sense", - "mimic", - "altered", - "synthetic", "arrays", - "mammalian", - "attempts", - "dyes", - "complex", - "fluoresce", + "senses", + "novo", + "shapes", "upon", - "train", + "hundreds", "settings", - "mixtures", - "fingerprints", - "various", - "biological", - "computationally", - "discriminates", - "accommodate", - "coupled", - "molecules", - "alternative", - "binding", + "system", + "small", + "channels", + "fluoresce", + "peptides", + "sensors", + "fluorophore", "predictably", - "range" + "range", + "employ", + "chemistries", + "robust", + "barrels" ], "release_date":"2022-03-02", "publication":"\"Differential sensing with arrays of de novo designed peptide assemblies\", Nat Commun, 14, 383-383", @@ -457162,6 +459128,10 @@ "sim":1.0, "partner":"7nfi" }, + { + "sim":1.0, + "partner":"8b16" + }, { "sim":1.0, "partner":"5ezc" @@ -457176,11 +459146,15 @@ }, { "sim":1.0, - "partner":"8b16" + "partner":"6zt1" }, { "sim":1.0, - "partner":"6zt1" + "partner":"7a1t" + }, + { + "sim":0.9549999833, + "partner":"8b15" }, { "sim":0.9955999851, @@ -457192,11 +459166,7 @@ }, { "sim":1.0, - "partner":"7a1t" - }, - { - "sim":0.9549999833, - "partner":"8b15" + "partner":"7bav" }, { "sim":1.0, @@ -457210,10 +459180,6 @@ "sim":1.0, "partner":"7bas" }, - { - "sim":1.0, - "partner":"7bav" - }, { "sim":1.0, "partner":"6g6g" @@ -457246,14 +459212,14 @@ "sim":0.9986000061, "partner":"6g67" }, - { - "sim":0.9933000207, - "partner":"6g6b" - }, { "sim":1.0, "partner":"7baw" }, + { + "sim":0.9933000207, + "partner":"6g6b" + }, { "sim":0.9769999981, "partner":"6yb0" @@ -457310,7 +459276,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"4pna" + "partner":"7nfl" }, "struct_max_sim_natural":[ @@ -457413,87 +459379,87 @@ ], "subtitle":"A hexameric barrel state of a de novo coiled-coil assembly: cc-type2-(laid)4-l14a", "tags":[ + "homomeric assembly", "de novo protein", "coiled coil", - "homomeric assembly", "synthetic peptide" ], "keywords":[ - "diverse", - "fluorimetric", - "displacement", - "drink", - "many", - "causes", - "channels", - "differential", - "chemistries", - "models", + "designed", "diagnostically", + "complex", + "alternative", + "central", + "mammalian", + "models", + "taste", + "coupled", + "challenging", + "fingerprints", + "many", + "drink", + "displacement", "receptors", - "use", - "patterns", - "hundreds", - "barrels", + "show", + "smell", + "diverse", + "accommodate", + "used", "de", - "novo", - "analytes", - "relate", - "sizes", - "identify", - "place", - "peptides", - "designed", - "senses", + "discriminates", + "computationally", "\u03b1hbs", - "challenging", + "attempts", + "altered", + "mixtures", + "biological", + "differential", + "potential", + "sizes", + "sense", + "fluorimetric", + "synthetic", + "mimic", + "causes", "samples", + "provide", + "dyes", "resulting", - "small", - "employ", - "used", - "taste", + "relate", + "place", + "various", "relevant", - "shapes", - "provide", - "robust", + "analytes", "vary", - "biomolecules", - "smell", - "system", - "fluorophore", - "sensors", - "potential", - "central", + "patterns", "chemically", - "show", + "binding", + "biomolecules", + "train", + "molecules", + "use", + "identify", "sensing", - "sense", - "mimic", - "altered", - "synthetic", "arrays", - "mammalian", - "attempts", - "dyes", - "complex", - "fluoresce", + "senses", + "novo", + "shapes", "upon", - "train", + "hundreds", "settings", - "mixtures", - "fingerprints", - "various", - "biological", - "computationally", - "discriminates", - "accommodate", - "coupled", - "molecules", - "alternative", - "binding", + "system", + "small", + "channels", + "fluoresce", + "peptides", + "sensors", + "fluorophore", "predictably", - "range" + "range", + "employ", + "chemistries", + "robust", + "barrels" ], "release_date":"2022-03-02", "publication":"\"Differential sensing with arrays of de novo designed peptide assemblies\", Nat Commun, 14, 383-383", @@ -457610,18 +459576,10 @@ "sim":1.0, "partner":"7nfm" }, - { - "sim":1.0, - "partner":"6zt1" - }, { "sim":0.9728000164, "partner":"7nfh" }, - { - "sim":0.9758999944, - "partner":"7nfo" - }, { "sim":0.9575999975, "partner":"7nfk" @@ -457630,6 +459588,14 @@ "sim":1.0, "partner":"6g6f" }, + { + "sim":1.0, + "partner":"6zt1" + }, + { + "sim":0.9758999944, + "partner":"7nfo" + }, { "sim":0.9980999827, "partner":"5ez9" @@ -457644,11 +459610,11 @@ }, { "sim":1.0, - "partner":"6xy0" + "partner":"6xxz" }, { "sim":1.0, - "partner":"6xxz" + "partner":"6xy0" }, { "sim":0.9769999981, @@ -457666,6 +459632,10 @@ "sim":0.996900022, "partner":"6g6d" }, + { + "sim":0.9943000078, + "partner":"7bat" + }, { "sim":1.0, "partner":"7baw" @@ -457674,10 +459644,6 @@ "sim":1.0, "partner":"5ezc" }, - { - "sim":0.9943000078, - "partner":"7bat" - }, { "sim":0.997600019, "partner":"6g65" @@ -457825,87 +459791,87 @@ ], "subtitle":"A heptameric barrel state of a de novo coiled-coil assembly: cc-type2-(maid)4", "tags":[ + "homomeric assembly", "de novo protein", "coiled coil", - "homomeric assembly", "synthetic peptide" ], "keywords":[ - "diverse", - "fluorimetric", - "displacement", - "drink", - "many", - "causes", - "channels", - "differential", - "chemistries", - "models", + "designed", "diagnostically", + "complex", + "alternative", + "central", + "mammalian", + "models", + "taste", + "coupled", + "challenging", + "fingerprints", + "many", + "drink", + "displacement", "receptors", - "use", - "patterns", - "hundreds", - "barrels", + "show", + "smell", + "diverse", + "accommodate", + "used", "de", - "novo", - "analytes", - "relate", - "sizes", - "identify", - "place", - "peptides", - "designed", - "senses", + "discriminates", + "computationally", "\u03b1hbs", - "challenging", + "attempts", + "altered", + "mixtures", + "biological", + "differential", + "potential", + "sizes", + "sense", + "fluorimetric", + "synthetic", + "mimic", + "causes", "samples", + "provide", + "dyes", "resulting", - "small", - "employ", - "used", - "taste", + "relate", + "place", + "various", "relevant", - "shapes", - "provide", - "robust", + "analytes", "vary", - "biomolecules", - "smell", - "system", - "fluorophore", - "sensors", - "potential", - "central", + "patterns", "chemically", - "show", + "binding", + "biomolecules", + "train", + "molecules", + "use", + "identify", "sensing", - "sense", - "mimic", - "altered", - "synthetic", "arrays", - "mammalian", - "attempts", - "dyes", - "complex", - "fluoresce", + "senses", + "novo", + "shapes", "upon", - "train", + "hundreds", "settings", - "mixtures", - "fingerprints", - "various", - "biological", - "computationally", - "discriminates", - "accommodate", - "coupled", - "molecules", - "alternative", - "binding", + "system", + "small", + "channels", + "fluoresce", + "peptides", + "sensors", + "fluorophore", "predictably", - "range" + "range", + "employ", + "chemistries", + "robust", + "barrels" ], "release_date":"2022-03-02", "publication":"\"Differential sensing with arrays of de novo designed peptide assemblies\", Nat Commun, 14, 383-383", @@ -457946,6 +459912,10 @@ "sim":0.9851999879, "partner":"6eiz" }, + { + "sim":0.9779999852, + "partner":"6g6g" + }, { "sim":0.9973999858, "partner":"6xy1" @@ -457966,6 +459936,14 @@ "sim":0.9789000154, "partner":"7nfj" }, + { + "sim":0.9738000035, + "partner":"6yb2" + }, + { + "sim":0.9648000002, + "partner":"6yaz" + }, { "sim":0.9789000154, "partner":"4pna" @@ -457978,6 +459956,10 @@ "sim":0.9789000154, "partner":"7bim" }, + { + "sim":0.9738000035, + "partner":"7nfl" + }, { "sim":0.9789000154, "partner":"8b15" @@ -457986,22 +459968,26 @@ "sim":0.9789000154, "partner":"8b16" }, - { - "sim":0.9779999852, - "partner":"6g6g" - }, { "sim":0.975399971, "partner":"7bav" }, { "sim":0.9738000035, - "partner":"7nfl" + "partner":"7nfg" }, { "sim":0.9789000154, "partner":"7bas" }, + { + "sim":0.9933000207, + "partner":"6g6d" + }, + { + "sim":0.9804000258, + "partner":"6g6f" + }, { "sim":0.9789000154, "partner":"5ez9" @@ -458011,12 +459997,8 @@ "partner":"7nfk" }, { - "sim":0.9703000188, - "partner":"6g6a" - }, - { - "sim":0.9804000258, - "partner":"6g6f" + "sim":0.9721000195, + "partner":"7nfm" }, { "sim":0.9774000049, @@ -458026,6 +460008,10 @@ "sim":0.9789000154, "partner":"7a1t" }, + { + "sim":0.9703000188, + "partner":"6g6a" + }, { "sim":0.9735999703, "partner":"7bat" @@ -458036,23 +460022,15 @@ }, { "sim":0.9738000035, - "partner":"6yb2" + "partner":"7nfi" }, { "sim":0.9789000154, "partner":"7nfn" }, { - "sim":1.0, - "partner":"7bau" - }, - { - "sim":0.9738000035, - "partner":"7nfg" - }, - { - "sim":0.9648000002, - "partner":"6yaz" + "sim":0.9768000245, + "partner":"7nff" }, { "sim":0.9789000154, @@ -458067,24 +460045,12 @@ "partner":"6g6b" }, { - "sim":0.9933000207, - "partner":"6g6d" - }, - { - "sim":0.9721000195, - "partner":"7nfm" - }, - { - "sim":0.9738000035, - "partner":"7nfi" - }, - { - "sim":0.9768000245, - "partner":"7nff" + "sim":1.0, + "partner":"7bau" }, { - "sim":0.954400003, - "partner":"6yb0" + "sim":0.9636999965, + "partner":"9gf2" }, { "sim":0.9738000035, @@ -458119,12 +460085,12 @@ "partner":"6xy0" }, { - "sim":0.9733999968, - "partner":"7bo9" + "sim":0.954400003, + "partner":"6yb0" }, { - "sim":0.9756000042, - "partner":"7bo8" + "sim":0.9987000227, + "partner":"4dzl" }, { "sim":0.970600009, @@ -458135,8 +460101,8 @@ "partner":"7nfp" }, { - "sim":0.9987000227, - "partner":"4dzl" + "sim":0.9756000042, + "partner":"7bo8" }, { "sim":0.9772999883, @@ -458146,6 +460112,10 @@ "sim":0.9738000035, "partner":"4dzn" }, + { + "sim":0.9733999968, + "partner":"7bo9" + }, { "sim":0.9743999839, "partner":"4dzk" @@ -458162,7 +460132,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"7nfo" + "partner":"7bau" }, "struct_max_sim_natural":[ @@ -458265,87 +460235,87 @@ ], "subtitle":"An octameric barrel state of a de novo coiled-coil assembly: cc-type2-(laid)4-l7y", "tags":[ + "homomeric assembly", "de novo protein", "coiled coil", - "homomeric assembly", "synthetic peptide" ], "keywords":[ - "diverse", - "fluorimetric", - "displacement", - "drink", - "many", - "causes", - "channels", - "differential", - "chemistries", - "models", + "designed", "diagnostically", + "complex", + "alternative", + "central", + "mammalian", + "models", + "taste", + "coupled", + "challenging", + "fingerprints", + "many", + "drink", + "displacement", "receptors", - "use", - "patterns", - "hundreds", - "barrels", + "show", + "smell", + "diverse", + "accommodate", + "used", "de", - "novo", - "analytes", - "relate", - "sizes", - "identify", - "place", - "peptides", - "designed", - "senses", + "discriminates", + "computationally", "\u03b1hbs", - "challenging", + "attempts", + "altered", + "mixtures", + "biological", + "differential", + "potential", + "sizes", + "sense", + "fluorimetric", + "synthetic", + "mimic", + "causes", "samples", + "provide", + "dyes", "resulting", - "small", - "employ", - "used", - "taste", + "relate", + "place", + "various", "relevant", - "shapes", - "provide", - "robust", + "analytes", "vary", - "biomolecules", - "smell", - "system", - "fluorophore", - "sensors", - "potential", - "central", + "patterns", "chemically", - "show", + "binding", + "biomolecules", + "train", + "molecules", + "use", + "identify", "sensing", - "sense", - "mimic", - "altered", - "synthetic", "arrays", - "mammalian", - "attempts", - "dyes", - "complex", - "fluoresce", + "senses", + "novo", + "shapes", "upon", - "train", + "hundreds", "settings", - "mixtures", - "fingerprints", - "various", - "biological", - "computationally", - "discriminates", - "accommodate", - "coupled", - "molecules", - "alternative", - "binding", + "system", + "small", + "channels", + "fluoresce", + "peptides", + "sensors", + "fluorophore", "predictably", - "range" + "range", + "employ", + "chemistries", + "robust", + "barrels" ], "release_date":"2022-03-02", "publication":"\"Differential sensing with arrays of de novo designed peptide assemblies\", Nat Commun, 14, 383-383", @@ -458406,14 +460376,14 @@ "sim":1.0, "partner":"7nfm" }, - { - "sim":0.9575999975, - "partner":"8a09" - }, { "sim":0.9979000092, "partner":"4pn9" }, + { + "sim":0.9575999975, + "partner":"8a09" + }, { "sim":0.9987999797, "partner":"6eiz" @@ -458438,6 +460408,10 @@ "sim":1.0, "partner":"8b16" }, + { + "sim":0.9972000122, + "partner":"6zt1" + }, { "sim":1.0, "partner":"7nfg" @@ -458447,8 +460421,8 @@ "partner":"5ez9" }, { - "sim":0.9972000122, - "partner":"6zt1" + "sim":1.0, + "partner":"6yb2" }, { "sim":1.0, @@ -458466,10 +460440,6 @@ "sim":1.0, "partner":"5eza" }, - { - "sim":1.0, - "partner":"6yb2" - }, { "sim":1.0, "partner":"7bas" @@ -458526,10 +460496,18 @@ "sim":1.0, "partner":"6g6f" }, + { + "sim":0.9933000207, + "partner":"6g6b" + }, { "sim":1.0, "partner":"7baw" }, + { + "sim":0.9569000006, + "partner":"9gf2" + }, { "sim":0.9769999981, "partner":"6yb0" @@ -458538,10 +460516,6 @@ "sim":0.9951999784, "partner":"6g6a" }, - { - "sim":0.9933000207, - "partner":"6g6b" - }, { "sim":0.9966999888, "partner":"6g6d" @@ -458677,87 +460651,87 @@ ], "subtitle":"A heptameric barrel state of a de novo coiled-coil assembly: cc-type2-(laid)4-l28y", "tags":[ + "homomeric assembly", "de novo protein", "coiled coil", - "homomeric assembly", "synthetic peptide" ], "keywords":[ - "diverse", - "fluorimetric", - "displacement", - "drink", - "many", - "causes", - "channels", - "differential", - "chemistries", - "models", + "designed", "diagnostically", + "complex", + "alternative", + "central", + "mammalian", + "models", + "taste", + "coupled", + "challenging", + "fingerprints", + "many", + "drink", + "displacement", "receptors", - "use", - "patterns", - "hundreds", - "barrels", + "show", + "smell", + "diverse", + "accommodate", + "used", "de", - "novo", - "analytes", - "relate", - "sizes", - "identify", - "place", - "peptides", - "designed", - "senses", + "discriminates", + "computationally", "\u03b1hbs", - "challenging", + "attempts", + "altered", + "mixtures", + "biological", + "differential", + "potential", + "sizes", + "sense", + "fluorimetric", + "synthetic", + "mimic", + "causes", "samples", + "provide", + "dyes", "resulting", - "small", - "employ", - "used", - "taste", + "relate", + "place", + "various", "relevant", - "shapes", - "provide", - "robust", + "analytes", "vary", - "biomolecules", - "smell", - "system", - "fluorophore", - "sensors", - "potential", - "central", + "patterns", "chemically", - "show", + "binding", + "biomolecules", + "train", + "molecules", + "use", + "identify", "sensing", - "sense", - "mimic", - "altered", - "synthetic", "arrays", - "mammalian", - "attempts", - "dyes", - "complex", - "fluoresce", + "senses", + "novo", + "shapes", "upon", - "train", + "hundreds", "settings", - "mixtures", - "fingerprints", - "various", - "biological", - "computationally", - "discriminates", - "accommodate", - "coupled", - "molecules", - "alternative", - "binding", + "system", + "small", + "channels", + "fluoresce", + "peptides", + "sensors", + "fluorophore", "predictably", - "range" + "range", + "employ", + "chemistries", + "robust", + "barrels" ], "release_date":"2022-03-02", "publication":"\"Differential sensing with arrays of de novo designed peptide assemblies\", Nat Commun, 14, 383-383", @@ -458796,63 +460770,55 @@ "struct_thr_sim_designed":[ { "sim":1.0, - "partner":"4pna" + "partner":"7nfl" }, { "sim":1.0, - "partner":"6xy1" + "partner":"4pna" }, { "sim":1.0, "partner":"7bim" }, - { - "sim":0.9987999797, - "partner":"4pn9" - }, { "sim":1.0, - "partner":"5ez8" + "partner":"6xy1" }, { - "sim":1.0, - "partner":"7nff" + "sim":0.9987999797, + "partner":"6eiz" }, { "sim":1.0, - "partner":"7nfi" + "partner":"5ez8" }, { "sim":1.0, - "partner":"7nfl" + "partner":"7nfk" }, { "sim":1.0, - "partner":"7nfm" - }, - { - "sim":0.9987999797, - "partner":"6eiz" + "partner":"8a09" }, { "sim":1.0, - "partner":"6g6g" + "partner":"7nfo" }, { - "sim":1.0, - "partner":"8b16" + "sim":0.9987999797, + "partner":"4pn9" }, { "sim":1.0, - "partner":"7nfg" + "partner":"7bav" }, { - "sim":1.0, - "partner":"7nfo" + "sim":0.9973000288, + "partner":"8b15" }, { "sim":1.0, - "partner":"6yb2" + "partner":"8b16" }, { "sim":0.9984999895, @@ -458860,23 +460826,23 @@ }, { "sim":1.0, - "partner":"7a1t" + "partner":"5ez9" }, { "sim":1.0, - "partner":"5ez9" + "partner":"6eik" }, { "sim":1.0, - "partner":"7bas" + "partner":"7nfh" }, { "sim":1.0, - "partner":"7bav" + "partner":"7a1t" }, { "sim":1.0, - "partner":"5eza" + "partner":"7bas" }, { "sim":1.0, @@ -458884,11 +460850,7 @@ }, { "sim":1.0, - "partner":"7nfh" - }, - { - "sim":0.9761999846, - "partner":"6yaz" + "partner":"6g6g" }, { "sim":1.0, @@ -458896,19 +460858,19 @@ }, { "sim":1.0, - "partner":"6xxz" + "partner":"7nff" }, { "sim":1.0, - "partner":"6xy0" + "partner":"7nfi" }, { "sim":1.0, - "partner":"7nfp" + "partner":"7nfm" }, { - "sim":1.0, - "partner":"6g6c" + "sim":0.9955999851, + "partner":"6g6b" }, { "sim":1.0, @@ -458916,87 +460878,103 @@ }, { "sim":1.0, - "partner":"6g65" + "partner":"7baw" }, { "sim":1.0, - "partner":"6g67" + "partner":"7nfg" }, { - "sim":0.9955999851, - "partner":"6g6b" + "sim":0.9947000146, + "partner":"6g6a" }, { "sim":1.0, - "partner":"7baw" + "partner":"6yb2" }, { - "sim":0.9947000146, - "partner":"6g6a" + "sim":0.996999979, + "partner":"7bat" }, { - "sim":0.9769999981, - "partner":"6yb0" + "sim":1.0, + "partner":"5eza" + }, + { + "sim":1.0, + "partner":"7bau" + }, + { + "sim":0.9761999846, + "partner":"6yaz" }, { "sim":0.9987000227, "partner":"6g6d" }, { - "sim":0.996999979, - "partner":"7bat" + "sim":1.0, + "partner":"6xy0" }, { "sim":1.0, - "partner":"7boa" + "partner":"6xxz" }, { "sim":1.0, - "partner":"6g66" + "partner":"7nfp" }, { "sim":1.0, - "partner":"7bau" + "partner":"6g6c" }, { "sim":1.0, - "partner":"4dzn" + "partner":"6g65" }, { "sim":1.0, - "partner":"7nfk" + "partner":"6g67" }, { - "sim":1.0, - "partner":"8a09" + "sim":0.9769999981, + "partner":"6yb0" }, { - "sim":0.9973000288, - "partner":"8b15" + "sim":1.0, + "partner":"7boa" }, { "sim":1.0, - "partner":"6eik" + "partner":"6g66" }, { - "sim":0.9592999816, - "partner":"5eze" + "sim":1.0, + "partner":"6g69" }, { "sim":0.9929000139, "partner":"7bo9" }, { - "sim":1.0, - "partner":"6g69" + "sim":0.9782000184, + "partner":"4dzl" }, { "sim":0.9983000159, "partner":"7bo8" }, { - "sim":0.9782000184, - "partner":"4dzl" + "sim":1.0, + "partner":"4dzn" + }, + { + "sim":0.9592999816, + "partner":"5eze" + }, + { + "sim":0.9642999768, + "partner":"9gf2" } ], "struct_thr_sim_natural":[ @@ -459010,7 +460988,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"4pna" + "partner":"7nfl" }, "struct_max_sim_natural":[ @@ -459113,87 +461091,87 @@ ], "subtitle":"An octameric barrel state of a de novo coiled-coil assembly: cc-type2-(laid)4-i24s", "tags":[ + "homomeric assembly", "de novo protein", "coiled coil", - "homomeric assembly", "synthetic peptide" ], "keywords":[ - "diverse", - "fluorimetric", - "displacement", - "drink", - "many", - "causes", - "channels", - "differential", - "chemistries", - "models", + "designed", "diagnostically", + "complex", + "alternative", + "central", + "mammalian", + "models", + "taste", + "coupled", + "challenging", + "fingerprints", + "many", + "drink", + "displacement", "receptors", - "use", - "patterns", - "hundreds", - "barrels", + "show", + "smell", + "diverse", + "accommodate", + "used", "de", - "novo", - "analytes", - "relate", - "sizes", - "identify", - "place", - "peptides", - "designed", - "senses", + "discriminates", + "computationally", "\u03b1hbs", - "challenging", + "attempts", + "altered", + "mixtures", + "biological", + "differential", + "potential", + "sizes", + "sense", + "fluorimetric", + "synthetic", + "mimic", + "causes", "samples", + "provide", + "dyes", "resulting", - "small", - "employ", - "used", - "taste", + "relate", + "place", + "various", "relevant", - "shapes", - "provide", - "robust", + "analytes", "vary", - "biomolecules", - "smell", - "system", - "fluorophore", - "sensors", - "potential", - "central", + "patterns", "chemically", - "show", + "binding", + "biomolecules", + "train", + "molecules", + "use", + "identify", "sensing", - "sense", - "mimic", - "altered", - "synthetic", "arrays", - "mammalian", - "attempts", - "dyes", - "complex", - "fluoresce", + "senses", + "novo", + "shapes", "upon", - "train", + "hundreds", "settings", - "mixtures", - "fingerprints", - "various", - "biological", - "computationally", - "discriminates", - "accommodate", - "coupled", - "molecules", - "alternative", - "binding", + "system", + "small", + "channels", + "fluoresce", + "peptides", + "sensors", + "fluorophore", "predictably", - "range" + "range", + "employ", + "chemistries", + "robust", + "barrels" ], "release_date":"2022-03-02", "publication":"\"Differential sensing with arrays of de novo designed peptide assemblies\", Nat Commun, 14, 383-383", @@ -459278,10 +461256,6 @@ "sim":0.9970999956, "partner":"8b15" }, - { - "sim":1.0, - "partner":"8b16" - }, { "sim":1.0, "partner":"5ez9" @@ -459292,12 +461266,16 @@ }, { "sim":1.0, - "partner":"6g6f" + "partner":"8b16" }, { "sim":1.0, "partner":"7a1t" }, + { + "sim":1.0, + "partner":"6g6f" + }, { "sim":1.0, "partner":"7bas" @@ -459316,11 +461294,11 @@ }, { "sim":1.0, - "partner":"7bav" + "partner":"7nff" }, { "sim":1.0, - "partner":"7nff" + "partner":"7bav" }, { "sim":0.9954000115, @@ -459334,14 +461312,14 @@ "sim":0.9916999936, "partner":"6g6a" }, - { - "sim":0.994599998, - "partner":"7bat" - }, { "sim":1.0, "partner":"7nfh" }, + { + "sim":0.994599998, + "partner":"7bat" + }, { "sim":1.0, "partner":"7nfm" @@ -459352,15 +461330,15 @@ }, { "sim":1.0, - "partner":"6g6g" + "partner":"7nfi" }, { "sim":1.0, - "partner":"7nfg" + "partner":"6g6g" }, { "sim":1.0, - "partner":"7nfi" + "partner":"7nfg" }, { "sim":1.0, @@ -459382,10 +461360,6 @@ "sim":0.9988999963, "partner":"6g6d" }, - { - "sim":0.9761999846, - "partner":"6yaz" - }, { "sim":1.0, "partner":"6xy0" @@ -459394,6 +461368,10 @@ "sim":0.9761999846, "partner":"7nfp" }, + { + "sim":0.9761999846, + "partner":"6yaz" + }, { "sim":1.0, "partner":"6g6c" @@ -459407,13 +461385,17 @@ "partner":"6g67" }, { - "sim":0.9761999846, - "partner":"6xxz" + "sim":0.9670000076, + "partner":"9gf2" }, { "sim":1.0, "partner":"6g66" }, + { + "sim":0.9761999846, + "partner":"6xxz" + }, { "sim":1.0, "partner":"7bo8" @@ -459545,87 +461527,87 @@ ], "subtitle":"An octameric barrel state of a de novo coiled-coil assembly: cc-type2-(laid)4-i24n", "tags":[ + "homomeric assembly", "de novo protein", "coiled coil", - "homomeric assembly", "synthetic peptide" ], "keywords":[ - "diverse", - "fluorimetric", - "displacement", - "drink", - "many", - "causes", - "channels", - "differential", - "chemistries", - "models", + "designed", "diagnostically", + "complex", + "alternative", + "central", + "mammalian", + "models", + "taste", + "coupled", + "challenging", + "fingerprints", + "many", + "drink", + "displacement", "receptors", - "use", - "patterns", - "hundreds", - "barrels", + "show", + "smell", + "diverse", + "accommodate", + "used", "de", - "novo", - "analytes", - "relate", - "sizes", - "identify", - "place", - "peptides", - "designed", - "senses", + "discriminates", + "computationally", "\u03b1hbs", - "challenging", + "attempts", + "altered", + "mixtures", + "biological", + "differential", + "potential", + "sizes", + "sense", + "fluorimetric", + "synthetic", + "mimic", + "causes", "samples", + "provide", + "dyes", "resulting", - "small", - "employ", - "used", - "taste", + "relate", + "place", + "various", "relevant", - "shapes", - "provide", - "robust", + "analytes", "vary", - "biomolecules", - "smell", - "system", - "fluorophore", - "sensors", - "potential", - "central", + "patterns", "chemically", - "show", + "binding", + "biomolecules", + "train", + "molecules", + "use", + "identify", "sensing", - "sense", - "mimic", - "altered", - "synthetic", "arrays", - "mammalian", - "attempts", - "dyes", - "complex", - "fluoresce", + "senses", + "novo", + "shapes", "upon", - "train", + "hundreds", "settings", - "mixtures", - "fingerprints", - "various", - "biological", - "computationally", - "discriminates", - "accommodate", - "coupled", - "molecules", - "alternative", - "binding", + "system", + "small", + "channels", + "fluoresce", + "peptides", + "sensors", + "fluorophore", "predictably", - "range" + "range", + "employ", + "chemistries", + "robust", + "barrels" ], "release_date":"2022-03-02", "publication":"\"Differential sensing with arrays of de novo designed peptide assemblies\", Nat Commun, 14, 383-383", @@ -459969,87 +461951,87 @@ ], "subtitle":"An octameric barrel state of a de novo coiled-coil assembly: cc-type2-(laid)4-l21k", "tags":[ + "homomeric assembly", "de novo protein", "coiled coil", - "homomeric assembly", "synthetic peptide" ], "keywords":[ - "diverse", - "fluorimetric", - "displacement", - "drink", - "many", - "causes", - "channels", - "differential", - "chemistries", - "models", + "designed", "diagnostically", + "complex", + "alternative", + "central", + "mammalian", + "models", + "taste", + "coupled", + "challenging", + "fingerprints", + "many", + "drink", + "displacement", "receptors", - "use", - "patterns", - "hundreds", - "barrels", + "show", + "smell", + "diverse", + "accommodate", + "used", "de", - "novo", - "analytes", - "relate", - "sizes", - "identify", - "place", - "peptides", - "designed", - "senses", + "discriminates", + "computationally", "\u03b1hbs", - "challenging", + "attempts", + "altered", + "mixtures", + "biological", + "differential", + "potential", + "sizes", + "sense", + "fluorimetric", + "synthetic", + "mimic", + "causes", "samples", + "provide", + "dyes", "resulting", - "small", - "employ", - "used", - "taste", + "relate", + "place", + "various", "relevant", - "shapes", - "provide", - "robust", + "analytes", "vary", - "biomolecules", - "smell", - "system", - "fluorophore", - "sensors", - "potential", - "central", + "patterns", "chemically", - "show", + "binding", + "biomolecules", + "train", + "molecules", + "use", + "identify", "sensing", - "sense", - "mimic", - "altered", - "synthetic", "arrays", - "mammalian", - "attempts", - "dyes", - "complex", - "fluoresce", + "senses", + "novo", + "shapes", "upon", - "train", + "hundreds", "settings", - "mixtures", - "fingerprints", - "various", - "biological", - "computationally", - "discriminates", - "accommodate", - "coupled", - "molecules", - "alternative", - "binding", + "system", + "small", + "channels", + "fluoresce", + "peptides", + "sensors", + "fluorophore", "predictably", - "range" + "range", + "employ", + "chemistries", + "robust", + "barrels" ], "release_date":"2022-03-02", "publication":"\"Differential sensing with arrays of de novo designed peptide assemblies\", Nat Commun, 14, 383-383", @@ -460108,15 +462090,15 @@ }, { "sim":1.0, - "partner":"7nfn" + "partner":"6yb2" }, { "sim":1.0, - "partner":"5eza" + "partner":"7nfn" }, { "sim":1.0, - "partner":"6yb2" + "partner":"5eza" }, { "sim":1.0, @@ -460389,87 +462371,87 @@ ], "subtitle":"A heptameric barrel state of a de novo coiled-coil assembly: cc-type2-(laid)4-l21n-i24n", "tags":[ + "homomeric assembly", "de novo protein", "coiled coil", - "homomeric assembly", "synthetic peptide" ], "keywords":[ - "diverse", - "fluorimetric", - "displacement", - "drink", - "many", - "causes", - "channels", - "differential", - "chemistries", - "models", + "designed", "diagnostically", + "complex", + "alternative", + "central", + "mammalian", + "models", + "taste", + "coupled", + "challenging", + "fingerprints", + "many", + "drink", + "displacement", "receptors", - "use", - "patterns", - "hundreds", - "barrels", + "show", + "smell", + "diverse", + "accommodate", + "used", "de", - "novo", - "analytes", - "relate", - "sizes", - "identify", - "place", - "peptides", - "designed", - "senses", + "discriminates", + "computationally", "\u03b1hbs", - "challenging", + "attempts", + "altered", + "mixtures", + "biological", + "differential", + "potential", + "sizes", + "sense", + "fluorimetric", + "synthetic", + "mimic", + "causes", "samples", + "provide", + "dyes", "resulting", - "small", - "employ", - "used", - "taste", + "relate", + "place", + "various", "relevant", - "shapes", - "provide", - "robust", + "analytes", "vary", - "biomolecules", - "smell", - "system", - "fluorophore", - "sensors", - "potential", - "central", + "patterns", "chemically", - "show", + "binding", + "biomolecules", + "train", + "molecules", + "use", + "identify", "sensing", - "sense", - "mimic", - "altered", - "synthetic", "arrays", - "mammalian", - "attempts", - "dyes", - "complex", - "fluoresce", + "senses", + "novo", + "shapes", "upon", - "train", + "hundreds", "settings", - "mixtures", - "fingerprints", - "various", - "biological", - "computationally", - "discriminates", - "accommodate", - "coupled", - "molecules", - "alternative", - "binding", + "system", + "small", + "channels", + "fluoresce", + "peptides", + "sensors", + "fluorophore", "predictably", - "range" + "range", + "employ", + "chemistries", + "robust", + "barrels" ], "release_date":"2022-03-02", "publication":"\"Differential sensing with arrays of de novo designed peptide assemblies\", Nat Commun, 14, 383-383", @@ -460512,15 +462494,15 @@ }, { "sim":1.0, - "partner":"5ez9" + "partner":"6eik" }, { "sim":1.0, - "partner":"5eza" + "partner":"5ez9" }, { "sim":1.0, - "partner":"6eik" + "partner":"7nfk" }, { "sim":1.0, @@ -460528,59 +462510,55 @@ }, { "sim":1.0, - "partner":"7nfp" - }, - { - "sim":1.0, - "partner":"7nfm" + "partner":"5ez8" }, { "sim":1.0, - "partner":"7nfk" + "partner":"5eza" }, { "sim":1.0, - "partner":"7nff" + "partner":"4pna" }, { "sim":1.0, - "partner":"5ez8" + "partner":"7bim" }, { "sim":1.0, - "partner":"4pna" + "partner":"7nfj" }, { "sim":1.0, - "partner":"7bim" + "partner":"8a09" }, { "sim":1.0, - "partner":"8a09" + "partner":"4pn9" }, { "sim":1.0, - "partner":"6xy1" + "partner":"6eiz" }, { "sim":1.0, - "partner":"6yb2" + "partner":"6zt1" }, { "sim":1.0, - "partner":"4pn9" + "partner":"7a1t" }, { "sim":1.0, - "partner":"7nfj" + "partner":"7bas" }, { "sim":1.0, - "partner":"6eiz" + "partner":"6g6f" }, { - "sim":1.0, - "partner":"7nfo" + "sim":0.9930999875, + "partner":"8b15" }, { "sim":1.0, @@ -460588,103 +462566,107 @@ }, { "sim":1.0, - "partner":"7nfg" + "partner":"7nfo" }, { "sim":1.0, - "partner":"7nfi" + "partner":"6xy1" }, { "sim":1.0, - "partner":"6zt1" + "partner":"7nfp" }, { "sim":1.0, - "partner":"7a1t" + "partner":"7nfm" }, { "sim":1.0, - "partner":"7bas" + "partner":"7bav" }, { - "sim":1.0, - "partner":"6g6g" + "sim":0.9951999784, + "partner":"6g6b" }, { "sim":1.0, - "partner":"7bav" + "partner":"7baw" }, { "sim":1.0, - "partner":"6g6f" - }, - { - "sim":0.9930999875, - "partner":"8b15" + "partner":"7nff" }, { - "sim":1.0, - "partner":"6xxz" + "sim":0.99150002, + "partner":"6g6a" }, { "sim":1.0, "partner":"7nfh" }, { - "sim":0.9769999981, - "partner":"6yb0" + "sim":0.9987000227, + "partner":"7bat" }, { "sim":1.0, - "partner":"6g6c" + "partner":"6yb2" }, { - "sim":0.9951999784, - "partner":"6g6b" + "sim":1.0, + "partner":"7bau" }, { "sim":1.0, - "partner":"6g65" + "partner":"6g6g" }, { "sim":1.0, - "partner":"6g67" + "partner":"7nfg" }, { "sim":1.0, - "partner":"7baw" + "partner":"7nfi" + }, + { + "sim":0.9769999981, + "partner":"6yb0" }, { "sim":0.9761999846, "partner":"6yaz" }, { - "sim":0.99150002, - "partner":"6g6a" + "sim":0.9896000028, + "partner":"7bo9" + }, + { + "sim":0.9973000288, + "partner":"6g6d" }, { "sim":1.0, - "partner":"4pn8" + "partner":"6g6c" }, { - "sim":0.9987000227, - "partner":"7bat" + "sim":1.0, + "partner":"6g65" }, { - "sim":0.9973000288, - "partner":"6g6d" + "sim":1.0, + "partner":"6g67" }, { "sim":1.0, - "partner":"6g66" + "partner":"4pn8" }, { "sim":1.0, - "partner":"7bau" + "partner":"6g66" }, { - "sim":0.9896000028, - "partner":"7bo9" + "sim":1.0, + "partner":"6xxz" }, { "sim":0.9951999784, @@ -460809,87 +462791,87 @@ ], "subtitle":"A hexameric barrel state of a de novo coiled-coil assembly: cc-type2-(laid)4-i17c", "tags":[ + "homomeric assembly", "de novo protein", "coiled coil", - "homomeric assembly", "synthetic peptide" ], "keywords":[ - "diverse", - "fluorimetric", - "displacement", - "drink", - "many", - "causes", - "channels", - "differential", - "chemistries", - "models", + "designed", "diagnostically", + "complex", + "alternative", + "central", + "mammalian", + "models", + "taste", + "coupled", + "challenging", + "fingerprints", + "many", + "drink", + "displacement", "receptors", - "use", - "patterns", - "hundreds", - "barrels", + "show", + "smell", + "diverse", + "accommodate", + "used", "de", - "novo", - "analytes", - "relate", - "sizes", - "identify", - "place", - "peptides", - "designed", - "senses", + "discriminates", + "computationally", "\u03b1hbs", - "challenging", + "attempts", + "altered", + "mixtures", + "biological", + "differential", + "potential", + "sizes", + "sense", + "fluorimetric", + "synthetic", + "mimic", + "causes", "samples", + "provide", + "dyes", "resulting", - "small", - "employ", - "used", - "taste", + "relate", + "place", + "various", "relevant", - "shapes", - "provide", - "robust", + "analytes", "vary", - "biomolecules", - "smell", - "system", - "fluorophore", - "sensors", - "potential", - "central", + "patterns", "chemically", - "show", + "binding", + "biomolecules", + "train", + "molecules", + "use", + "identify", "sensing", - "sense", - "mimic", - "altered", - "synthetic", "arrays", - "mammalian", - "attempts", - "dyes", - "complex", - "fluoresce", + "senses", + "novo", + "shapes", "upon", - "train", + "hundreds", "settings", - "mixtures", - "fingerprints", - "various", - "biological", - "computationally", - "discriminates", - "accommodate", - "coupled", - "molecules", - "alternative", - "binding", + "system", + "small", + "channels", + "fluoresce", + "peptides", + "sensors", + "fluorophore", "predictably", - "range" + "range", + "employ", + "chemistries", + "robust", + "barrels" ], "release_date":"2022-03-02", "publication":"\"Differential sensing with arrays of de novo designed peptide assemblies\", Nat Commun, 14, 383-383", @@ -460930,6 +462912,10 @@ "sim":0.9933999777, "partner":"6xy1" }, + { + "sim":0.9821000099, + "partner":"6eiz" + }, { "sim":0.9789000154, "partner":"8a09" @@ -460939,8 +462925,8 @@ "partner":"8b16" }, { - "sim":0.9821000099, - "partner":"6eiz" + "sim":1.0, + "partner":"7nfh" }, { "sim":0.9789000154, @@ -460958,10 +462944,6 @@ "sim":0.9789000154, "partner":"7bim" }, - { - "sim":0.9768000245, - "partner":"5eza" - }, { "sim":0.9789000154, "partner":"7nfj" @@ -460986,10 +462968,6 @@ "sim":0.9724000096, "partner":"7bav" }, - { - "sim":0.9747999907, - "partner":"6g6f" - }, { "sim":0.9789000154, "partner":"7bas" @@ -460998,6 +462976,10 @@ "sim":0.9789000154, "partner":"5ez9" }, + { + "sim":0.9747999907, + "partner":"6g6f" + }, { "sim":0.9779000282, "partner":"6zt1" @@ -461007,21 +462989,37 @@ "partner":"7a1t" }, { - "sim":0.975399971, - "partner":"6g6g" + "sim":0.9789000154, + "partner":"6eik" + }, + { + "sim":0.9768000245, + "partner":"5eza" }, { "sim":1.0, - "partner":"7nfh" + "partner":"7bau" }, { "sim":0.9789000154, - "partner":"6eik" + "partner":"7nfn" + }, + { + "sim":0.9692000151, + "partner":"6g6b" + }, + { + "sim":0.975399971, + "partner":"6g6g" }, { "sim":0.9767000079, "partner":"7nff" }, + { + "sim":0.9789000154, + "partner":"7baw" + }, { "sim":0.9720000029, "partner":"7nfi" @@ -461031,45 +463029,29 @@ "partner":"7nfm" }, { - "sim":0.9789000154, - "partner":"7nfn" - }, - { - "sim":0.9768000245, - "partner":"6xy0" + "sim":0.9686999917, + "partner":"6g6a" }, { - "sim":0.9739000201, - "partner":"6yb2" + "sim":0.9750999808, + "partner":"7bat" }, { "sim":0.9725999832, "partner":"7nfg" }, { - "sim":0.9692000151, - "partner":"6g6b" + "sim":0.954400003, + "partner":"6yb0" }, { - "sim":0.9869999886, - "partner":"6g6d" + "sim":0.9739000201, + "partner":"6yb2" }, { "sim":0.975300014, "partner":"7nfp" }, - { - "sim":0.9789000154, - "partner":"7baw" - }, - { - "sim":0.9686999917, - "partner":"6g6a" - }, - { - "sim":0.9750999808, - "partner":"7bat" - }, { "sim":0.9811999798, "partner":"6g6c" @@ -461079,8 +463061,16 @@ "partner":"6xxz" }, { - "sim":1.0, - "partner":"7bau" + "sim":0.9768000245, + "partner":"6xy0" + }, + { + "sim":0.9613999724, + "partner":"6yaz" + }, + { + "sim":0.9720000029, + "partner":"7bo9" }, { "sim":0.9695000052, @@ -461091,40 +463081,36 @@ "partner":"6g67" }, { - "sim":0.9747999907, - "partner":"7bo8" + "sim":0.9869999886, + "partner":"6g6d" }, { - "sim":0.9758999944, - "partner":"6g66" + "sim":1.0, + "partner":"4dzl" + }, + { + "sim":0.9747999907, + "partner":"7bo8" }, { "sim":0.9901000261, "partner":"6g69" }, { - "sim":0.9720000029, - "partner":"7bo9" + "sim":0.9758999944, + "partner":"6g66" }, { "sim":0.9750999808, "partner":"7boa" }, { - "sim":1.0, - "partner":"4dzl" + "sim":0.9501000047, + "partner":"9gf2" }, { "sim":0.9739999771, "partner":"4pn8" - }, - { - "sim":0.954400003, - "partner":"6yb0" - }, - { - "sim":0.9613999724, - "partner":"6yaz" } ], "struct_thr_sim_natural":[ @@ -461241,87 +463227,87 @@ ], "subtitle":"A heptameric barrel state of a de novo coiled-coil assembly: cc-type2-(laid)4-i17k", "tags":[ + "homomeric assembly", "de novo protein", "coiled coil", - "homomeric assembly", "synthetic peptide" ], "keywords":[ - "diverse", - "fluorimetric", - "displacement", - "drink", - "many", - "causes", - "channels", - "differential", - "chemistries", - "models", + "designed", "diagnostically", + "complex", + "alternative", + "central", + "mammalian", + "models", + "taste", + "coupled", + "challenging", + "fingerprints", + "many", + "drink", + "displacement", "receptors", - "use", - "patterns", - "hundreds", - "barrels", + "show", + "smell", + "diverse", + "accommodate", + "used", "de", - "novo", - "analytes", - "relate", - "sizes", - "identify", - "place", - "peptides", - "designed", - "senses", + "discriminates", + "computationally", "\u03b1hbs", - "challenging", + "attempts", + "altered", + "mixtures", + "biological", + "differential", + "potential", + "sizes", + "sense", + "fluorimetric", + "synthetic", + "mimic", + "causes", "samples", + "provide", + "dyes", "resulting", - "small", - "employ", - "used", - "taste", + "relate", + "place", + "various", "relevant", - "shapes", - "provide", - "robust", + "analytes", "vary", - "biomolecules", - "smell", - "system", - "fluorophore", - "sensors", - "potential", - "central", + "patterns", "chemically", - "show", + "binding", + "biomolecules", + "train", + "molecules", + "use", + "identify", "sensing", - "sense", - "mimic", - "altered", - "synthetic", "arrays", - "mammalian", - "attempts", - "dyes", - "complex", - "fluoresce", + "senses", + "novo", + "shapes", "upon", - "train", + "hundreds", "settings", - "mixtures", - "fingerprints", - "various", - "biological", - "computationally", - "discriminates", - "accommodate", - "coupled", - "molecules", - "alternative", - "binding", + "system", + "small", + "channels", + "fluoresce", + "peptides", + "sensors", + "fluorophore", "predictably", - "range" + "range", + "employ", + "chemistries", + "robust", + "barrels" ], "release_date":"2022-03-02", "publication":"\"Differential sensing with arrays of de novo designed peptide assemblies\", Nat Commun, 14, 383-383", @@ -461623,90 +463609,90 @@ ], "subtitle":"Solution structure of boskar4; a de novo designed g-csf agonist", "tags":[ - "g-csf agonist", "de novo protein", "protein design", - "four-helix bundle" + "four-helix bundle", + "g-csf agonist" ], "keywords":[ + "granulopoietic", "largely", - "independent", - "aggregation", - "matches", - "change", - "frequently", - "strategy", - "including", - "designed", - "towards", - "obtain", + "structural", "show", + "thermostable", "therefore", - "structure", - "instability", - "primary", - "novel", + "solubility", + "topological", + "stem", + "new", + "strategy", + "protein", + "readily", + "novo", + "demonstrate", + "cells", + "major", + "two", + "face", + "mature", "starting", - "thermostable", - "utility", - "challenges", + "aggregation", + "specific", + "targets", + "matches", + "address", + "approach", "proteins", - "testing", - "face", - "de", + "accuracy", + "factor", "highly", - "mature", - "starkly", - "production", - "nanomolar", - "therapeutics", - "granulopoietic", - "complicated", - "haematopoietic", - "atomic", - "native", "stimulating", "four", - "address", - "active", - "activity", - "specific", + "nanomolar", + "including", "design", + "starkly", "context", - "stem", - "sequence", - "cells", - "structural", - "neutrophils", - "range", - "accuracy", - "solubility", - "demonstrate", - "factor", - "optimising", - "designs", - "poor", - "applicable", - "differentiating", + "atomic", + "active", + "therapeutics", + "testing", + "different", + "fold", + "instability", "also", - "approach", - "novo", + "independent", + "applicable", "wide", - "human", - "fold", - "different", - "topological", - "two", - "rearranging", - "significant", - "protein", - "possess", - "targets", - "readily", + "utility", + "complicated", + "primary", + "poor", + "differentiating", + "sequence", + "range", + "production", + "obtain", + "designed", "vivo", - "major", + "de", + "neutrophils", + "structure", + "possess", + "challenges", + "rearranging", + "frequently", + "haematopoietic", "refactoring", - "new" + "change", + "towards", + "activity", + "native", + "human", + "designs", + "optimising", + "novel", + "significant" ], "release_date":"2021-10-06", "publication":"\"A topological refactoring design strategy yields highly stable granulopoietic proteins\", Nat Commun, 13, 2948-2948", @@ -461753,11 +463739,11 @@ }, { "sim":83.0, - "partner":"1cd9" + "partner":"1pgr" }, { "sim":83.0, - "partner":"1pgr" + "partner":"1cd9" }, { "sim":83.0, @@ -461850,9 +463836,9 @@ ], "subtitle":"Azacoelenterazine-bound renilla-type engineered ancestral luciferase variant (ancft7)", "tags":[ - "azacoelenterazine-bound enzyme", "luminescent protein", - "bioluminscence" + "bioluminscence", + "azacoelenterazine-bound enzyme" ], "keywords":[ "description", @@ -462031,11 +464017,11 @@ }, { "sim":286.0, - "partner":"1iz8" + "partner":"1k63" }, { "sim":286.0, - "partner":"1k63" + "partner":"1iz8" }, { "sim":286.0, @@ -462095,11 +464081,11 @@ }, { "sim":263.0, - "partner":"3rk4" + "partner":"4f5z" }, { "sim":263.0, - "partner":"4f5z" + "partner":"3rk4" }, { "sim":262.0, @@ -462123,11 +464109,11 @@ }, { "sim":259.0, - "partner":"3fwh" + "partner":"3g9x" }, { "sim":259.0, - "partner":"3g9x" + "partner":"3fwh" }, { "sim":254.0, @@ -462207,19 +464193,19 @@ }, { "sim":241.0, - "partner":"7pcw" + "partner":"6y7b" }, { "sim":241.0, - "partner":"6y7a" + "partner":"6zvw" }, { "sim":241.0, - "partner":"6y7b" + "partner":"7pcw" }, { "sim":241.0, - "partner":"6zvw" + "partner":"6y7a" }, { "sim":241.0, @@ -462261,10 +464247,6 @@ "sim":238.0, "partner":"2v9z" }, - { - "sim":237.0, - "partner":"6zvu" - }, { "sim":237.0, "partner":"6zvv" @@ -462277,6 +464259,10 @@ "sim":237.0, "partner":"6zvy" }, + { + "sim":237.0, + "partner":"6zvu" + }, { "sim":236.0, "partner":"6y9e" @@ -462367,11 +464353,11 @@ }, { "sim":74.0, - "partner":"5y6y" + "partner":"5yb5" }, { "sim":74.0, - "partner":"5yb5" + "partner":"5y6y" }, { "sim":74.0, @@ -462397,18 +464383,6 @@ "sim":70.0, "partner":"1bee" }, - { - "sim":69.0, - "partner":"2dhc" - }, - { - "sim":69.0, - "partner":"2dhd" - }, - { - "sim":69.0, - "partner":"2dhe" - }, { "sim":69.0, "partner":"2had" @@ -462427,11 +464401,11 @@ }, { "sim":69.0, - "partner":"1cij" + "partner":"2yxp" }, { "sim":69.0, - "partner":"2yxp" + "partner":"1cij" }, { "sim":69.0, @@ -462449,10 +464423,22 @@ "sim":69.0, "partner":"1ede" }, + { + "sim":69.0, + "partner":"2dhc" + }, { "sim":69.0, "partner":"1be0" }, + { + "sim":69.0, + "partner":"2dhd" + }, + { + "sim":69.0, + "partner":"2dhe" + }, { "sim":68.0, "partner":"7ac0" @@ -462497,21 +464483,13 @@ "sim":59.0, "partner":"6yl4" }, - { - "sim":59.0, - "partner":"6fr2" - }, { "sim":59.0, "partner":"7a7g" }, { "sim":59.0, - "partner":"4y2x" - }, - { - "sim":59.0, - "partner":"4y2y" + "partner":"6fr2" }, { "sim":59.0, @@ -462589,6 +464567,14 @@ "sim":59.0, "partner":"4y2v" }, + { + "sim":59.0, + "partner":"4y2x" + }, + { + "sim":59.0, + "partner":"4y2y" + }, { "sim":55.0, "partner":"7dq9" @@ -462609,18 +464595,6 @@ "sim":53.0, "partner":"3pdc" }, - { - "sim":53.0, - "partner":"5ald" - }, - { - "sim":53.0, - "partner":"5ale" - }, - { - "sim":53.0, - "partner":"5alf" - }, { "sim":53.0, "partner":"5ake" @@ -462825,6 +464799,18 @@ "sim":53.0, "partner":"5ai6" }, + { + "sim":53.0, + "partner":"5ald" + }, + { + "sim":53.0, + "partner":"5ale" + }, + { + "sim":53.0, + "partner":"5alf" + }, { "sim":52.0, "partner":"4mea" @@ -462917,10 +464903,6 @@ "sim":51.0, "partner":"5xmd" }, - { - "sim":51.0, - "partner":"6aum" - }, { "sim":51.0, "partner":"3i28" @@ -462977,6 +464959,10 @@ "sim":51.0, "partner":"1zd5" }, + { + "sim":51.0, + "partner":"6aum" + }, { "sim":50.0, "partner":"4meb" @@ -463059,12 +465045,12 @@ ], "subtitle":"Crystal structure of the computationally designed sake6ae protein", "tags":[ - "layer", - "beta propeller", + "self-assembly", + "designer", "synthetic", "unknown function", - "designer", - "self-assembly" + "beta propeller", + "layer" ], "keywords":[ "description", @@ -463157,11 +465143,11 @@ }, { "sim":451.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":451.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":451.0, @@ -463215,19 +465201,19 @@ }, { "sim":303.0, - "partner":"7xm3" + "partner":"7xm2" }, { "sim":303.0, - "partner":"7xm4" + "partner":"7xm3" }, { "sim":303.0, - "partner":"7xm5" + "partner":"7xm4" }, { "sim":303.0, - "partner":"7xm2" + "partner":"7xm5" }, { "sim":303.0, @@ -463257,14 +465243,6 @@ "sim":302.0, "partner":"6hws" }, - { - "sim":302.0, - "partner":"5x54" - }, - { - "sim":302.0, - "partner":"6rog" - }, { "sim":302.0, "partner":"4ifj" @@ -463279,7 +465257,11 @@ }, { "sim":302.0, - "partner":"4l7d" + "partner":"5x54" + }, + { + "sim":302.0, + "partner":"6rog" }, { "sim":302.0, @@ -463293,6 +465275,10 @@ "sim":302.0, "partner":"4n1b" }, + { + "sim":302.0, + "partner":"4l7d" + }, { "sim":302.0, "partner":"7k2h" @@ -463393,10 +465379,6 @@ "sim":298.0, "partner":"5wfl" }, - { - "sim":297.0, - "partner":"7k2r" - }, { "sim":297.0, "partner":"7k28" @@ -463423,7 +465405,7 @@ }, { "sim":297.0, - "partner":"7q5h" + "partner":"7k2r" }, { "sim":297.0, @@ -463447,7 +465429,7 @@ }, { "sim":297.0, - "partner":"7k2g" + "partner":"7q5h" }, { "sim":297.0, @@ -463473,6 +465455,10 @@ "sim":297.0, "partner":"7k2e" }, + { + "sim":297.0, + "partner":"7k2g" + }, { "sim":296.0, "partner":"7k2l" @@ -463529,25 +465515,17 @@ "sim":294.0, "partner":"6zez" }, - { - "sim":294.0, - "partner":"5fnq" - }, { "sim":294.0, "partner":"6zf0" }, - { - "sim":294.0, - "partner":"5fnr" - }, { "sim":294.0, "partner":"6zf1" }, { "sim":294.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":294.0, @@ -463555,7 +465533,7 @@ }, { "sim":294.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":294.0, @@ -463563,19 +465541,23 @@ }, { "sim":294.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":294.0, "partner":"6zf4" }, + { + "sim":294.0, + "partner":"5fnt" + }, { "sim":294.0, "partner":"6zf5" }, { "sim":294.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":294.0, @@ -463585,6 +465567,10 @@ "sim":294.0, "partner":"6zf7" }, + { + "sim":294.0, + "partner":"5fzj" + }, { "sim":294.0, "partner":"6zf8" @@ -463595,11 +465581,11 @@ }, { "sim":294.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":294.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":294.0, @@ -463627,15 +465613,15 @@ }, { "sim":293.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":293.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":293.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":293.0, @@ -463705,10 +465691,6 @@ "sim":252.0, "partner":"5nkp" }, - { - "sim":244.0, - "partner":"8rbh" - }, { "sim":244.0, "partner":"6v7o" @@ -463722,13 +465704,17 @@ "partner":"6ttk" }, { - "sim":238.0, - "partner":"2xn4" + "sim":244.0, + "partner":"8rbh" }, { "sim":238.0, "partner":"4chb" }, + { + "sim":238.0, + "partner":"2xn4" + }, { "sim":225.0, "partner":"5yy8" @@ -463739,11 +465725,11 @@ }, { "sim":154.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":154.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":129.0, @@ -463863,12 +465849,12 @@ ], "subtitle":"Crystal structure of the computationally designed sake6be-l2 protein", "tags":[ - "layer", - "beta propeller", + "self-assembly", + "designer", "synthetic", "unknown function", - "designer", - "self-assembly" + "beta propeller", + "layer" ], "keywords":[ "description", @@ -463921,11 +465907,11 @@ }, { "sim":522.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":522.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":522.0, @@ -464039,19 +466025,19 @@ }, { "sim":284.0, - "partner":"7xm3" + "partner":"7xm2" }, { "sim":284.0, - "partner":"7xm4" + "partner":"7xm3" }, { "sim":284.0, - "partner":"7xm5" + "partner":"7xm4" }, { "sim":284.0, - "partner":"7xm2" + "partner":"7xm5" }, { "sim":284.0, @@ -464077,10 +466063,6 @@ "sim":283.0, "partner":"6hws" }, - { - "sim":283.0, - "partner":"6rog" - }, { "sim":283.0, "partner":"4ifj" @@ -464095,7 +466077,7 @@ }, { "sim":283.0, - "partner":"4l7d" + "partner":"6rog" }, { "sim":283.0, @@ -464109,6 +466091,10 @@ "sim":283.0, "partner":"4n1b" }, + { + "sim":283.0, + "partner":"4l7d" + }, { "sim":283.0, "partner":"7k2h" @@ -464205,25 +466191,17 @@ "sim":281.0, "partner":"6zez" }, - { - "sim":281.0, - "partner":"5fnq" - }, { "sim":281.0, "partner":"6zf0" }, - { - "sim":281.0, - "partner":"5fnr" - }, { "sim":281.0, "partner":"6zf1" }, { "sim":281.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":281.0, @@ -464231,7 +466209,7 @@ }, { "sim":281.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":281.0, @@ -464239,19 +466217,23 @@ }, { "sim":281.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":281.0, "partner":"6zf4" }, + { + "sim":281.0, + "partner":"5fnt" + }, { "sim":281.0, "partner":"6zf5" }, { "sim":281.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":281.0, @@ -464261,6 +466243,10 @@ "sim":281.0, "partner":"6zf7" }, + { + "sim":281.0, + "partner":"5fzj" + }, { "sim":281.0, "partner":"6zf8" @@ -464347,11 +466333,11 @@ }, { "sim":280.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":280.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":280.0, @@ -464375,15 +466361,15 @@ }, { "sim":279.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":279.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":279.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":279.0, @@ -464409,10 +466395,6 @@ "sim":279.0, "partner":"5wfl" }, - { - "sim":278.0, - "partner":"7k2r" - }, { "sim":278.0, "partner":"7k28" @@ -464439,7 +466421,7 @@ }, { "sim":278.0, - "partner":"7q5h" + "partner":"7k2r" }, { "sim":278.0, @@ -464463,7 +466445,7 @@ }, { "sim":278.0, - "partner":"7k2g" + "partner":"7q5h" }, { "sim":278.0, @@ -464489,6 +466471,10 @@ "sim":278.0, "partner":"7k2e" }, + { + "sim":278.0, + "partner":"7k2g" + }, { "sim":277.0, "partner":"7k2l" @@ -464503,11 +466489,11 @@ }, { "sim":252.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":252.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":247.0, @@ -464517,10 +466503,6 @@ "sim":247.0, "partner":"5nkp" }, - { - "sim":228.0, - "partner":"8rbh" - }, { "sim":228.0, "partner":"6v7o" @@ -464533,6 +466515,10 @@ "sim":228.0, "partner":"6ttk" }, + { + "sim":228.0, + "partner":"8rbh" + }, { "sim":216.0, "partner":"5yy8" @@ -464543,11 +466529,11 @@ }, { "sim":158.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":158.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":118.0, @@ -464727,12 +466713,12 @@ ], "subtitle":"Crystal structure of the computationally designed sake6ar protein", "tags":[ - "layer", - "beta propeller", + "self-assembly", + "designer", "synthetic", "unknown function", - "designer", - "self-assembly" + "beta propeller", + "layer" ], "keywords":[ "description", @@ -464813,11 +466799,11 @@ }, { "sim":472.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":472.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":472.0, @@ -464845,11 +466831,11 @@ }, { "sim":384.0, - "partner":"8pjx" + "partner":"8pjw" }, { "sim":384.0, - "partner":"8pjw" + "partner":"8pjx" }, { "sim":169.0, @@ -464883,19 +466869,19 @@ }, { "sim":309.0, - "partner":"7xm3" + "partner":"7xm2" }, { "sim":309.0, - "partner":"7xm4" + "partner":"7xm3" }, { "sim":309.0, - "partner":"7xm5" + "partner":"7xm4" }, { "sim":309.0, - "partner":"7xm2" + "partner":"7xm5" }, { "sim":309.0, @@ -464925,14 +466911,6 @@ "sim":307.0, "partner":"6hws" }, - { - "sim":307.0, - "partner":"5x54" - }, - { - "sim":307.0, - "partner":"6rog" - }, { "sim":307.0, "partner":"4ifj" @@ -464947,7 +466925,11 @@ }, { "sim":307.0, - "partner":"4l7d" + "partner":"5x54" + }, + { + "sim":307.0, + "partner":"6rog" }, { "sim":307.0, @@ -464961,6 +466943,10 @@ "sim":307.0, "partner":"4n1b" }, + { + "sim":307.0, + "partner":"4l7d" + }, { "sim":307.0, "partner":"7k2h" @@ -465085,25 +467071,17 @@ "sim":304.0, "partner":"6zez" }, - { - "sim":304.0, - "partner":"5fnq" - }, { "sim":304.0, "partner":"6zf0" }, - { - "sim":304.0, - "partner":"5fnr" - }, { "sim":304.0, "partner":"6zf1" }, { "sim":304.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":304.0, @@ -465111,7 +467089,7 @@ }, { "sim":304.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":304.0, @@ -465119,19 +467097,23 @@ }, { "sim":304.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":304.0, "partner":"6zf4" }, + { + "sim":304.0, + "partner":"5fnt" + }, { "sim":304.0, "partner":"6zf5" }, { "sim":304.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":304.0, @@ -465141,6 +467123,10 @@ "sim":304.0, "partner":"6zf7" }, + { + "sim":304.0, + "partner":"5fzj" + }, { "sim":304.0, "partner":"6zf8" @@ -465199,11 +467185,11 @@ }, { "sim":303.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":303.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":303.0, @@ -465249,10 +467235,6 @@ "sim":303.0, "partner":"5wfl" }, - { - "sim":302.0, - "partner":"7k2r" - }, { "sim":302.0, "partner":"7k28" @@ -465279,11 +467261,11 @@ }, { "sim":302.0, - "partner":"7ofe" + "partner":"7k2r" }, { "sim":302.0, - "partner":"7q5h" + "partner":"7ofe" }, { "sim":302.0, @@ -465307,7 +467289,7 @@ }, { "sim":302.0, - "partner":"7k2g" + "partner":"7q5h" }, { "sim":302.0, @@ -465335,7 +467317,7 @@ }, { "sim":302.0, - "partner":"4zy3" + "partner":"7k2g" }, { "sim":302.0, @@ -465345,6 +467327,10 @@ "sim":302.0, "partner":"3wn7" }, + { + "sim":302.0, + "partner":"4zy3" + }, { "sim":301.0, "partner":"7k2l" @@ -465363,11 +467349,11 @@ }, { "sim":264.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":264.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":262.0, @@ -465381,10 +467367,6 @@ "sim":256.0, "partner":"5nkp" }, - { - "sim":242.0, - "partner":"8rbh" - }, { "sim":242.0, "partner":"6v7o" @@ -465397,6 +467379,10 @@ "sim":242.0, "partner":"6ttk" }, + { + "sim":242.0, + "partner":"8rbh" + }, { "sim":226.0, "partner":"5yy8" @@ -465407,11 +467393,11 @@ }, { "sim":156.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":156.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":120.0, @@ -465523,12 +467509,12 @@ ], "subtitle":"Crystal structure of the computationally designed sake6ac protein", "tags":[ - "layer", - "beta propeller", + "self-assembly", + "designer", "synthetic", "unknown function", - "designer", - "self-assembly" + "beta propeller", + "layer" ], "keywords":[ "description", @@ -465621,11 +467607,11 @@ }, { "sim":453.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":453.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":453.0, @@ -465687,23 +467673,19 @@ }, { "sim":304.0, - "partner":"7xm3" - }, - { - "sim":304.0, - "partner":"7xm4" + "partner":"7xm2" }, { "sim":304.0, - "partner":"7xm5" + "partner":"7xm3" }, { "sim":304.0, - "partner":"7xm2" + "partner":"7xm4" }, { "sim":304.0, - "partner":"4l7d" + "partner":"7xm5" }, { "sim":304.0, @@ -465717,6 +467699,10 @@ "sim":304.0, "partner":"4n1b" }, + { + "sim":304.0, + "partner":"4l7d" + }, { "sim":304.0, "partner":"1zgk" @@ -465751,23 +467737,23 @@ }, { "sim":303.0, - "partner":"5x54" + "partner":"4ifj" }, { "sim":303.0, - "partner":"6rog" + "partner":"4ifl" }, { "sim":303.0, - "partner":"4ifj" + "partner":"4ifn" }, { "sim":303.0, - "partner":"4ifl" + "partner":"5x54" }, { "sim":303.0, - "partner":"4ifn" + "partner":"6rog" }, { "sim":303.0, @@ -465873,25 +467859,17 @@ "sim":300.0, "partner":"6zez" }, - { - "sim":300.0, - "partner":"5fnq" - }, { "sim":300.0, "partner":"6zf0" }, - { - "sim":300.0, - "partner":"5fnr" - }, { "sim":300.0, "partner":"6zf1" }, { "sim":300.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":300.0, @@ -465899,7 +467877,7 @@ }, { "sim":300.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":300.0, @@ -465907,19 +467885,23 @@ }, { "sim":300.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":300.0, "partner":"6zf4" }, + { + "sim":300.0, + "partner":"5fnt" + }, { "sim":300.0, "partner":"6zf5" }, { "sim":300.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":300.0, @@ -465929,6 +467911,10 @@ "sim":300.0, "partner":"6zf7" }, + { + "sim":300.0, + "partner":"5fzj" + }, { "sim":300.0, "partner":"6zf8" @@ -465947,11 +467933,11 @@ }, { "sim":300.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":300.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":300.0, @@ -466027,15 +468013,15 @@ }, { "sim":299.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":299.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":299.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":299.0, @@ -466061,10 +468047,6 @@ "sim":299.0, "partner":"5wfl" }, - { - "sim":298.0, - "partner":"7k2r" - }, { "sim":298.0, "partner":"7k28" @@ -466091,7 +468073,7 @@ }, { "sim":298.0, - "partner":"7k2g" + "partner":"7k2r" }, { "sim":298.0, @@ -466118,16 +468100,16 @@ "partner":"7k2e" }, { - "sim":297.0, - "partner":"7k2l" + "sim":298.0, + "partner":"7k2g" }, { "sim":297.0, - "partner":"7k2m" + "partner":"7k2l" }, { "sim":297.0, - "partner":"7q5h" + "partner":"7k2m" }, { "sim":297.0, @@ -466149,6 +468131,10 @@ "sim":297.0, "partner":"7q6s" }, + { + "sim":297.0, + "partner":"7q5h" + }, { "sim":274.0, "partner":"5yq4" @@ -466157,10 +468143,6 @@ "sim":274.0, "partner":"6gy5" }, - { - "sim":256.0, - "partner":"8rbh" - }, { "sim":256.0, "partner":"6v7o" @@ -466173,6 +468155,10 @@ "sim":256.0, "partner":"6ttk" }, + { + "sim":256.0, + "partner":"8rbh" + }, { "sim":252.0, "partner":"6hrl" @@ -466187,11 +468173,11 @@ }, { "sim":240.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":240.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":239.0, @@ -466203,11 +468189,11 @@ }, { "sim":162.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":162.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":128.0, @@ -466399,12 +468385,12 @@ ], "subtitle":"Crystal structure of the computationally designed sake6be protein", "tags":[ - "layer", - "beta propeller", + "self-assembly", + "designer", "synthetic", "unknown function", - "designer", - "self-assembly" + "beta propeller", + "layer" ], "keywords":[ "description", @@ -466445,11 +468431,11 @@ }, { "sim":571.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":571.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":571.0, @@ -466575,19 +468561,19 @@ }, { "sim":311.0, - "partner":"7xm3" + "partner":"7xm2" }, { "sim":311.0, - "partner":"7xm4" + "partner":"7xm3" }, { "sim":311.0, - "partner":"7xm5" + "partner":"7xm4" }, { "sim":311.0, - "partner":"7xm2" + "partner":"7xm5" }, { "sim":311.0, @@ -466613,14 +468599,6 @@ "sim":310.0, "partner":"6hws" }, - { - "sim":310.0, - "partner":"5x54" - }, - { - "sim":310.0, - "partner":"6rog" - }, { "sim":310.0, "partner":"4ifj" @@ -466635,7 +468613,11 @@ }, { "sim":310.0, - "partner":"4l7d" + "partner":"5x54" + }, + { + "sim":310.0, + "partner":"6rog" }, { "sim":310.0, @@ -466649,6 +468631,10 @@ "sim":310.0, "partner":"4n1b" }, + { + "sim":310.0, + "partner":"4l7d" + }, { "sim":310.0, "partner":"7k2h" @@ -466741,25 +468727,17 @@ "sim":308.0, "partner":"6zez" }, - { - "sim":308.0, - "partner":"5fnq" - }, { "sim":308.0, "partner":"6zf0" }, - { - "sim":308.0, - "partner":"5fnr" - }, { "sim":308.0, "partner":"6zf1" }, { "sim":308.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":308.0, @@ -466767,7 +468745,7 @@ }, { "sim":308.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":308.0, @@ -466775,19 +468753,23 @@ }, { "sim":308.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":308.0, "partner":"6zf4" }, + { + "sim":308.0, + "partner":"5fnt" + }, { "sim":308.0, "partner":"6zf5" }, { "sim":308.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":308.0, @@ -466797,6 +468779,10 @@ "sim":308.0, "partner":"6zf7" }, + { + "sim":308.0, + "partner":"5fzj" + }, { "sim":308.0, "partner":"6zf8" @@ -466807,11 +468793,11 @@ }, { "sim":308.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":308.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":308.0, @@ -466911,15 +468897,15 @@ }, { "sim":306.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":306.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":306.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":306.0, @@ -466945,10 +468931,6 @@ "sim":306.0, "partner":"5wfl" }, - { - "sim":305.0, - "partner":"7k2r" - }, { "sim":305.0, "partner":"7k28" @@ -466975,7 +468957,7 @@ }, { "sim":305.0, - "partner":"7q5h" + "partner":"7k2r" }, { "sim":305.0, @@ -466999,7 +468981,7 @@ }, { "sim":305.0, - "partner":"7k2g" + "partner":"7q5h" }, { "sim":305.0, @@ -467025,6 +469007,10 @@ "sim":305.0, "partner":"7k2e" }, + { + "sim":305.0, + "partner":"7k2g" + }, { "sim":304.0, "partner":"7k2l" @@ -467039,11 +469025,11 @@ }, { "sim":276.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":276.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":271.0, @@ -467053,10 +469039,6 @@ "sim":271.0, "partner":"5nkp" }, - { - "sim":260.0, - "partner":"8rbh" - }, { "sim":260.0, "partner":"6v7o" @@ -467069,6 +469051,10 @@ "sim":260.0, "partner":"6ttk" }, + { + "sim":260.0, + "partner":"8rbh" + }, { "sim":245.0, "partner":"5yy8" @@ -467079,11 +469065,11 @@ }, { "sim":178.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":178.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":128.0, @@ -467258,12 +469244,12 @@ ], "subtitle":"Crystal structure of the self-assembled sake6be designer protein", "tags":[ - "layer", - "beta propeller", + "self-assembly", + "designer", "synthetic", "unknown function", - "designer", - "self-assembly" + "beta propeller", + "layer" ], "keywords":[ "description", @@ -467304,11 +469290,11 @@ }, { "sim":571.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":571.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":571.0, @@ -467434,19 +469420,19 @@ }, { "sim":311.0, - "partner":"7xm3" + "partner":"7xm2" }, { "sim":311.0, - "partner":"7xm4" + "partner":"7xm3" }, { "sim":311.0, - "partner":"7xm5" + "partner":"7xm4" }, { "sim":311.0, - "partner":"7xm2" + "partner":"7xm5" }, { "sim":311.0, @@ -467472,14 +469458,6 @@ "sim":310.0, "partner":"6hws" }, - { - "sim":310.0, - "partner":"5x54" - }, - { - "sim":310.0, - "partner":"6rog" - }, { "sim":310.0, "partner":"4ifj" @@ -467494,7 +469472,11 @@ }, { "sim":310.0, - "partner":"4l7d" + "partner":"5x54" + }, + { + "sim":310.0, + "partner":"6rog" }, { "sim":310.0, @@ -467508,6 +469490,10 @@ "sim":310.0, "partner":"4n1b" }, + { + "sim":310.0, + "partner":"4l7d" + }, { "sim":310.0, "partner":"7k2h" @@ -467600,25 +469586,17 @@ "sim":308.0, "partner":"6zez" }, - { - "sim":308.0, - "partner":"5fnq" - }, { "sim":308.0, "partner":"6zf0" }, - { - "sim":308.0, - "partner":"5fnr" - }, { "sim":308.0, "partner":"6zf1" }, { "sim":308.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":308.0, @@ -467626,7 +469604,7 @@ }, { "sim":308.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":308.0, @@ -467634,19 +469612,23 @@ }, { "sim":308.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":308.0, "partner":"6zf4" }, + { + "sim":308.0, + "partner":"5fnt" + }, { "sim":308.0, "partner":"6zf5" }, { "sim":308.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":308.0, @@ -467656,6 +469638,10 @@ "sim":308.0, "partner":"6zf7" }, + { + "sim":308.0, + "partner":"5fzj" + }, { "sim":308.0, "partner":"6zf8" @@ -467666,11 +469652,11 @@ }, { "sim":308.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":308.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":308.0, @@ -467770,15 +469756,15 @@ }, { "sim":306.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":306.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":306.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":306.0, @@ -467804,10 +469790,6 @@ "sim":306.0, "partner":"5wfl" }, - { - "sim":305.0, - "partner":"7k2r" - }, { "sim":305.0, "partner":"7k28" @@ -467834,7 +469816,7 @@ }, { "sim":305.0, - "partner":"7q5h" + "partner":"7k2r" }, { "sim":305.0, @@ -467858,7 +469840,7 @@ }, { "sim":305.0, - "partner":"7k2g" + "partner":"7q5h" }, { "sim":305.0, @@ -467884,6 +469866,10 @@ "sim":305.0, "partner":"7k2e" }, + { + "sim":305.0, + "partner":"7k2g" + }, { "sim":304.0, "partner":"7k2l" @@ -467898,11 +469884,11 @@ }, { "sim":276.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":276.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":271.0, @@ -467912,10 +469898,6 @@ "sim":271.0, "partner":"5nkp" }, - { - "sim":260.0, - "partner":"8rbh" - }, { "sim":260.0, "partner":"6v7o" @@ -467928,6 +469910,10 @@ "sim":260.0, "partner":"6ttk" }, + { + "sim":260.0, + "partner":"8rbh" + }, { "sim":245.0, "partner":"5yy8" @@ -467938,11 +469924,11 @@ }, { "sim":178.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":178.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":128.0, @@ -468117,12 +470103,12 @@ ], "subtitle":"Crystal structure of the computationally designed sake6be-l1 protein", "tags":[ - "layer", - "beta propeller", + "self-assembly", + "designer", "synthetic", "unknown function", - "designer", - "self-assembly" + "beta propeller", + "layer" ], "keywords":[ "description", @@ -468167,11 +470153,11 @@ }, { "sim":541.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":541.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":541.0, @@ -468293,19 +470279,19 @@ }, { "sim":289.0, - "partner":"7xm3" + "partner":"7xm2" }, { "sim":289.0, - "partner":"7xm4" + "partner":"7xm3" }, { "sim":289.0, - "partner":"7xm5" + "partner":"7xm4" }, { "sim":289.0, - "partner":"7xm2" + "partner":"7xm5" }, { "sim":289.0, @@ -468335,14 +470321,6 @@ "sim":288.0, "partner":"6hws" }, - { - "sim":288.0, - "partner":"5x54" - }, - { - "sim":288.0, - "partner":"6rog" - }, { "sim":288.0, "partner":"4ifj" @@ -468357,7 +470335,11 @@ }, { "sim":288.0, - "partner":"4l7d" + "partner":"5x54" + }, + { + "sim":288.0, + "partner":"6rog" }, { "sim":288.0, @@ -468371,6 +470353,10 @@ "sim":288.0, "partner":"4n1b" }, + { + "sim":288.0, + "partner":"4l7d" + }, { "sim":288.0, "partner":"7k2h" @@ -468475,25 +470461,17 @@ "sim":286.0, "partner":"6zez" }, - { - "sim":286.0, - "partner":"5fnq" - }, { "sim":286.0, "partner":"6zf0" }, - { - "sim":286.0, - "partner":"5fnr" - }, { "sim":286.0, "partner":"6zf1" }, { "sim":286.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":286.0, @@ -468501,7 +470479,7 @@ }, { "sim":286.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":286.0, @@ -468509,19 +470487,23 @@ }, { "sim":286.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":286.0, "partner":"6zf4" }, + { + "sim":286.0, + "partner":"5fnt" + }, { "sim":286.0, "partner":"6zf5" }, { "sim":286.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":286.0, @@ -468531,6 +470513,10 @@ "sim":286.0, "partner":"6zf7" }, + { + "sim":286.0, + "partner":"5fzj" + }, { "sim":286.0, "partner":"6zf8" @@ -468549,11 +470535,11 @@ }, { "sim":286.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":286.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":286.0, @@ -468627,10 +470613,6 @@ "sim":285.0, "partner":"7ofe" }, - { - "sim":284.0, - "partner":"7k2r" - }, { "sim":284.0, "partner":"7k28" @@ -468657,7 +470639,7 @@ }, { "sim":284.0, - "partner":"7k2g" + "partner":"7k2r" }, { "sim":284.0, @@ -468685,7 +470667,7 @@ }, { "sim":284.0, - "partner":"4zy3" + "partner":"7k2g" }, { "sim":284.0, @@ -468695,6 +470677,10 @@ "sim":284.0, "partner":"3wn7" }, + { + "sim":284.0, + "partner":"4zy3" + }, { "sim":284.0, "partner":"5wfv" @@ -468727,10 +470713,6 @@ "sim":283.0, "partner":"7k2m" }, - { - "sim":283.0, - "partner":"7q5h" - }, { "sim":283.0, "partner":"6z6a" @@ -468751,17 +470733,21 @@ "sim":283.0, "partner":"7q6s" }, + { + "sim":283.0, + "partner":"7q5h" + }, { "sim":263.0, "partner":"6hrl" }, { "sim":254.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":254.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":250.0, @@ -468771,10 +470757,6 @@ "sim":250.0, "partner":"5nkp" }, - { - "sim":239.0, - "partner":"8rbh" - }, { "sim":239.0, "partner":"6v7o" @@ -468787,6 +470769,10 @@ "sim":239.0, "partner":"6ttk" }, + { + "sim":239.0, + "partner":"8rbh" + }, { "sim":225.0, "partner":"5yy8" @@ -468797,11 +470783,11 @@ }, { "sim":164.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":164.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":121.0, @@ -468913,12 +470899,12 @@ ], "subtitle":"Crystal structure of the computationally designed sake6be-l3 protein", "tags":[ - "layer", - "beta propeller", + "self-assembly", + "designer", "synthetic", "unknown function", - "designer", - "self-assembly" + "beta propeller", + "layer" ], "keywords":[ "description", @@ -468975,11 +470961,11 @@ }, { "sim":486.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":486.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":486.0, @@ -469069,19 +471055,19 @@ }, { "sim":276.0, - "partner":"7xm3" + "partner":"7xm2" }, { "sim":276.0, - "partner":"7xm4" + "partner":"7xm3" }, { "sim":276.0, - "partner":"7xm5" + "partner":"7xm4" }, { "sim":276.0, - "partner":"7xm2" + "partner":"7xm5" }, { "sim":276.0, @@ -469131,14 +471117,6 @@ "sim":274.0, "partner":"6hws" }, - { - "sim":274.0, - "partner":"5x54" - }, - { - "sim":274.0, - "partner":"6rog" - }, { "sim":274.0, "partner":"4ifj" @@ -469153,7 +471131,11 @@ }, { "sim":274.0, - "partner":"4l7d" + "partner":"5x54" + }, + { + "sim":274.0, + "partner":"6rog" }, { "sim":274.0, @@ -469167,6 +471149,10 @@ "sim":274.0, "partner":"4n1b" }, + { + "sim":274.0, + "partner":"4l7d" + }, { "sim":274.0, "partner":"7k2h" @@ -469255,25 +471241,17 @@ "sim":273.0, "partner":"6zez" }, - { - "sim":273.0, - "partner":"5fnq" - }, { "sim":273.0, "partner":"6zf0" }, - { - "sim":273.0, - "partner":"5fnr" - }, { "sim":273.0, "partner":"6zf1" }, { "sim":273.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":273.0, @@ -469281,7 +471259,7 @@ }, { "sim":273.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":273.0, @@ -469289,19 +471267,23 @@ }, { "sim":273.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":273.0, "partner":"6zf4" }, + { + "sim":273.0, + "partner":"5fnt" + }, { "sim":273.0, "partner":"6zf5" }, { "sim":273.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":273.0, @@ -469311,6 +471293,10 @@ "sim":273.0, "partner":"6zf7" }, + { + "sim":273.0, + "partner":"5fzj" + }, { "sim":273.0, "partner":"6zf8" @@ -469321,11 +471307,11 @@ }, { "sim":273.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":273.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":273.0, @@ -469425,15 +471411,15 @@ }, { "sim":271.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":271.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":271.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":271.0, @@ -469459,10 +471445,6 @@ "sim":271.0, "partner":"5wfl" }, - { - "sim":270.0, - "partner":"7k2r" - }, { "sim":270.0, "partner":"7k28" @@ -469489,7 +471471,7 @@ }, { "sim":270.0, - "partner":"7k2g" + "partner":"7k2r" }, { "sim":270.0, @@ -469516,16 +471498,16 @@ "partner":"7k2e" }, { - "sim":269.0, - "partner":"7k2l" + "sim":270.0, + "partner":"7k2g" }, { "sim":269.0, - "partner":"7k2m" + "partner":"7k2l" }, { "sim":269.0, - "partner":"7q5h" + "partner":"7k2m" }, { "sim":269.0, @@ -469548,13 +471530,17 @@ "partner":"7q6s" }, { - "sim":245.0, - "partner":"2xn4" + "sim":269.0, + "partner":"7q5h" }, { "sim":245.0, "partner":"4chb" }, + { + "sim":245.0, + "partner":"2xn4" + }, { "sim":242.0, "partner":"4ch9" @@ -469567,10 +471553,6 @@ "sim":240.0, "partner":"6hrl" }, - { - "sim":213.0, - "partner":"8rbh" - }, { "sim":213.0, "partner":"6v7o" @@ -469583,6 +471565,10 @@ "sim":213.0, "partner":"6ttk" }, + { + "sim":213.0, + "partner":"8rbh" + }, { "sim":206.0, "partner":"5yy8" @@ -469593,11 +471579,11 @@ }, { "sim":143.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":143.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":137.0, @@ -469702,12 +471688,12 @@ ], "subtitle":"Crystal structure of the computationally designed sake6be-3hh protein", "tags":[ - "layer", - "beta propeller", + "self-assembly", + "designer", "synthetic", "unknown function", - "designer", - "self-assembly" + "beta propeller", + "layer" ], "keywords":[ "description", @@ -469744,11 +471730,11 @@ "seq_thr_sim_designed":[ { "sim":590.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":590.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":571.0, @@ -469878,19 +471864,19 @@ }, { "sim":305.0, - "partner":"7xm3" + "partner":"7xm2" }, { "sim":305.0, - "partner":"7xm4" + "partner":"7xm3" }, { "sim":305.0, - "partner":"7xm5" + "partner":"7xm4" }, { "sim":305.0, - "partner":"7xm2" + "partner":"7xm5" }, { "sim":305.0, @@ -469916,14 +471902,6 @@ "sim":304.0, "partner":"6hws" }, - { - "sim":304.0, - "partner":"5x54" - }, - { - "sim":304.0, - "partner":"6rog" - }, { "sim":304.0, "partner":"4ifj" @@ -469938,7 +471916,11 @@ }, { "sim":304.0, - "partner":"4l7d" + "partner":"5x54" + }, + { + "sim":304.0, + "partner":"6rog" }, { "sim":304.0, @@ -469952,6 +471934,10 @@ "sim":304.0, "partner":"4n1b" }, + { + "sim":304.0, + "partner":"4l7d" + }, { "sim":304.0, "partner":"7k2h" @@ -470044,25 +472030,17 @@ "sim":302.0, "partner":"6zez" }, - { - "sim":302.0, - "partner":"5fnq" - }, { "sim":302.0, "partner":"6zf0" }, - { - "sim":302.0, - "partner":"5fnr" - }, { "sim":302.0, "partner":"6zf1" }, { "sim":302.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":302.0, @@ -470070,7 +472048,7 @@ }, { "sim":302.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":302.0, @@ -470078,19 +472056,23 @@ }, { "sim":302.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":302.0, "partner":"6zf4" }, + { + "sim":302.0, + "partner":"5fnt" + }, { "sim":302.0, "partner":"6zf5" }, { "sim":302.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":302.0, @@ -470100,6 +472082,10 @@ "sim":302.0, "partner":"6zf7" }, + { + "sim":302.0, + "partner":"5fzj" + }, { "sim":302.0, "partner":"6zf8" @@ -470110,11 +472096,11 @@ }, { "sim":302.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":302.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":302.0, @@ -470214,15 +472200,15 @@ }, { "sim":301.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":301.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":301.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":300.0, @@ -470256,10 +472242,6 @@ "sim":299.0, "partner":"7k2m" }, - { - "sim":299.0, - "partner":"7k2r" - }, { "sim":299.0, "partner":"7k28" @@ -470286,7 +472268,7 @@ }, { "sim":299.0, - "partner":"7q5h" + "partner":"7k2r" }, { "sim":299.0, @@ -470310,7 +472292,7 @@ }, { "sim":299.0, - "partner":"7k2g" + "partner":"7q5h" }, { "sim":299.0, @@ -470336,17 +472318,21 @@ "sim":299.0, "partner":"7k2e" }, + { + "sim":299.0, + "partner":"7k2g" + }, { "sim":281.0, "partner":"6hrl" }, { "sim":273.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":273.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":268.0, @@ -470356,10 +472342,6 @@ "sim":268.0, "partner":"5nkp" }, - { - "sim":262.0, - "partner":"8rbh" - }, { "sim":262.0, "partner":"6v7o" @@ -470372,6 +472354,10 @@ "sim":262.0, "partner":"6ttk" }, + { + "sim":262.0, + "partner":"8rbh" + }, { "sim":242.0, "partner":"5yy8" @@ -470382,11 +472368,11 @@ }, { "sim":173.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":173.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":123.0, @@ -470495,7 +472481,7 @@ ], "seq_max_sim_designed":{ "sim":590.0, - "partner":"7opu" + "partner":"7opv" }, "seq_max_sim_natural":{ "sim":325.0, @@ -470561,12 +472547,12 @@ ], "subtitle":"Self-assembled crystal structure of the computationally designed sake6be-3hh protein", "tags":[ - "layer", - "beta propeller", + "self-assembly", + "designer", "synthetic", "unknown function", - "designer", - "self-assembly" + "beta propeller", + "layer" ], "keywords":[ "description", @@ -470737,19 +472723,19 @@ }, { "sim":305.0, - "partner":"7xm3" + "partner":"7xm2" }, { "sim":305.0, - "partner":"7xm4" + "partner":"7xm3" }, { "sim":305.0, - "partner":"7xm5" + "partner":"7xm4" }, { "sim":305.0, - "partner":"7xm2" + "partner":"7xm5" }, { "sim":305.0, @@ -470775,14 +472761,6 @@ "sim":304.0, "partner":"6hws" }, - { - "sim":304.0, - "partner":"5x54" - }, - { - "sim":304.0, - "partner":"6rog" - }, { "sim":304.0, "partner":"4ifj" @@ -470797,7 +472775,11 @@ }, { "sim":304.0, - "partner":"4l7d" + "partner":"5x54" + }, + { + "sim":304.0, + "partner":"6rog" }, { "sim":304.0, @@ -470811,6 +472793,10 @@ "sim":304.0, "partner":"4n1b" }, + { + "sim":304.0, + "partner":"4l7d" + }, { "sim":304.0, "partner":"7k2h" @@ -470903,25 +472889,17 @@ "sim":302.0, "partner":"6zez" }, - { - "sim":302.0, - "partner":"5fnq" - }, { "sim":302.0, "partner":"6zf0" }, - { - "sim":302.0, - "partner":"5fnr" - }, { "sim":302.0, "partner":"6zf1" }, { "sim":302.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":302.0, @@ -470929,7 +472907,7 @@ }, { "sim":302.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":302.0, @@ -470937,19 +472915,23 @@ }, { "sim":302.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":302.0, "partner":"6zf4" }, + { + "sim":302.0, + "partner":"5fnt" + }, { "sim":302.0, "partner":"6zf5" }, { "sim":302.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":302.0, @@ -470959,6 +472941,10 @@ "sim":302.0, "partner":"6zf7" }, + { + "sim":302.0, + "partner":"5fzj" + }, { "sim":302.0, "partner":"6zf8" @@ -470969,11 +472955,11 @@ }, { "sim":302.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":302.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":302.0, @@ -471073,15 +473059,15 @@ }, { "sim":301.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":301.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":301.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":300.0, @@ -471115,10 +473101,6 @@ "sim":299.0, "partner":"7k2m" }, - { - "sim":299.0, - "partner":"7k2r" - }, { "sim":299.0, "partner":"7k28" @@ -471145,7 +473127,7 @@ }, { "sim":299.0, - "partner":"7q5h" + "partner":"7k2r" }, { "sim":299.0, @@ -471169,7 +473151,7 @@ }, { "sim":299.0, - "partner":"7k2g" + "partner":"7q5h" }, { "sim":299.0, @@ -471195,17 +473177,21 @@ "sim":299.0, "partner":"7k2e" }, + { + "sim":299.0, + "partner":"7k2g" + }, { "sim":281.0, "partner":"6hrl" }, { "sim":273.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":273.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":268.0, @@ -471215,10 +473201,6 @@ "sim":268.0, "partner":"5nkp" }, - { - "sim":262.0, - "partner":"8rbh" - }, { "sim":262.0, "partner":"6v7o" @@ -471231,6 +473213,10 @@ "sim":262.0, "partner":"6ttk" }, + { + "sim":262.0, + "partner":"8rbh" + }, { "sim":242.0, "partner":"5yy8" @@ -471241,11 +473227,11 @@ }, { "sim":173.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":173.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":123.0, @@ -471420,12 +473406,12 @@ ], "subtitle":"Crystal structure of the computationally designed sake6be-3hh protein, alternative packing", "tags":[ - "layer", - "beta propeller", + "self-assembly", + "designer", "synthetic", "unknown function", - "designer", - "self-assembly" + "beta propeller", + "layer" ], "keywords":[ "description", @@ -471596,19 +473582,19 @@ }, { "sim":305.0, - "partner":"7xm3" + "partner":"7xm2" }, { "sim":305.0, - "partner":"7xm4" + "partner":"7xm3" }, { "sim":305.0, - "partner":"7xm5" + "partner":"7xm4" }, { "sim":305.0, - "partner":"7xm2" + "partner":"7xm5" }, { "sim":305.0, @@ -471634,14 +473620,6 @@ "sim":304.0, "partner":"6hws" }, - { - "sim":304.0, - "partner":"5x54" - }, - { - "sim":304.0, - "partner":"6rog" - }, { "sim":304.0, "partner":"4ifj" @@ -471656,7 +473634,11 @@ }, { "sim":304.0, - "partner":"4l7d" + "partner":"5x54" + }, + { + "sim":304.0, + "partner":"6rog" }, { "sim":304.0, @@ -471670,6 +473652,10 @@ "sim":304.0, "partner":"4n1b" }, + { + "sim":304.0, + "partner":"4l7d" + }, { "sim":304.0, "partner":"7k2h" @@ -471762,25 +473748,17 @@ "sim":302.0, "partner":"6zez" }, - { - "sim":302.0, - "partner":"5fnq" - }, { "sim":302.0, "partner":"6zf0" }, - { - "sim":302.0, - "partner":"5fnr" - }, { "sim":302.0, "partner":"6zf1" }, { "sim":302.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":302.0, @@ -471788,7 +473766,7 @@ }, { "sim":302.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":302.0, @@ -471796,19 +473774,23 @@ }, { "sim":302.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":302.0, "partner":"6zf4" }, + { + "sim":302.0, + "partner":"5fnt" + }, { "sim":302.0, "partner":"6zf5" }, { "sim":302.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":302.0, @@ -471818,6 +473800,10 @@ "sim":302.0, "partner":"6zf7" }, + { + "sim":302.0, + "partner":"5fzj" + }, { "sim":302.0, "partner":"6zf8" @@ -471828,11 +473814,11 @@ }, { "sim":302.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":302.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":302.0, @@ -471932,15 +473918,15 @@ }, { "sim":301.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":301.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":301.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":300.0, @@ -471974,10 +473960,6 @@ "sim":299.0, "partner":"7k2m" }, - { - "sim":299.0, - "partner":"7k2r" - }, { "sim":299.0, "partner":"7k28" @@ -472004,7 +473986,7 @@ }, { "sim":299.0, - "partner":"7q5h" + "partner":"7k2r" }, { "sim":299.0, @@ -472028,7 +474010,7 @@ }, { "sim":299.0, - "partner":"7k2g" + "partner":"7q5h" }, { "sim":299.0, @@ -472054,17 +474036,21 @@ "sim":299.0, "partner":"7k2e" }, + { + "sim":299.0, + "partner":"7k2g" + }, { "sim":281.0, "partner":"6hrl" }, { "sim":273.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":273.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":268.0, @@ -472074,10 +474060,6 @@ "sim":268.0, "partner":"5nkp" }, - { - "sim":262.0, - "partner":"8rbh" - }, { "sim":262.0, "partner":"6v7o" @@ -472090,6 +474072,10 @@ "sim":262.0, "partner":"6ttk" }, + { + "sim":262.0, + "partner":"8rbh" + }, { "sim":242.0, "partner":"5yy8" @@ -472100,11 +474086,11 @@ }, { "sim":173.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":173.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":123.0, @@ -472271,94 +474257,94 @@ ], "subtitle":"Stim11nocys-sb, a de novo designed tim barrel with a salt-bridge cluster (crystal form 1)", "tags":[ - "salt bridge cluster", + "tim barrel", "de novo protein", - "tim barrel" + "salt bridge cluster" ], "keywords":[ - "work", - "analysis", - "ordered", - "results", - "background", - "bridge", - "stabilizing", - "thermostability", - "challenge", - "cluster", - "geometries", - "prediction", - "crystal", - "modeling", - "features", + "engineering", + "hydrophobic", + "structural", "show", "therefore", - "structure", + "background", + "single", + "differences", + "three", + "results", + "bridge", + "model", + "protein", + "salt", + "tendency", + "changes", + "stabilization", "networks", - "predict", - "formed", + "novo", + "major", + "two", + "crystal", + "effects", + "similarities", "parental", - "proteins", "similar", - "de", - "similarities", - "variants", - "dependence", - "clusters", - "influence", - "highly", - "difficult", - "destabilizing", - "differently", - "structures", - "modifying", - "three", "either", - "exhibit", - "effects", - "properties", - "stability", - "salt", - "changes", + "conformational", + "formed", + "stabilizing", + "influence", + "effect", "bridges", - "among", - "engineering", - "observed", + "disulfide", + "depending", + "stability", + "destabilizing", + "proteins", + "highly", + "predict", + "since", + "features", "introduced", + "barrel", + "geometries", + "exhibit", "design", - "model", - "comparison", - "hydrophobic", "context", - "effect", - "high", + "work", + "different", + "environment", + "clusters", + "properties", + "rosetta", + "fold", "good", - "disulfide", - "structural", + "third", + "prediction", + "explore", + "modifying", + "modeling", + "dependence", + "analysis", + "differently", + "variants", + "observed", + "structures", + "de", + "structure", + "thermostability", "important", + "among", + "cluster", + "high", + "difficult", + "cores", "tim", - "stabilization", - "depending", - "designs", "despite", - "conformational", - "tendency", + "challenge", + "designs", + "ordered", "barrels", - "novo", - "single", - "barrel", - "rosetta", - "fold", - "different", - "two", - "explore", - "cores", - "protein", - "differences", - "third", - "environment", - "major", - "since" + "comparison" ], "release_date":"2021-12-15", "publication":"\"A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels\", Protein Sci., 31, 513-527", @@ -472522,94 +474508,94 @@ ], "subtitle":"Denovotim6-sb, a de novo designed tim barrel with a salt-bridge cluster (crystal form 1)", "tags":[ - "salt bridge cluster", + "tim barrel", "de novo protein", - "tim barrel" + "salt bridge cluster" ], "keywords":[ - "work", - "analysis", - "ordered", - "results", - "background", - "bridge", - "stabilizing", - "thermostability", - "challenge", - "cluster", - "geometries", - "prediction", - "crystal", - "modeling", - "features", + "engineering", + "hydrophobic", + "structural", "show", "therefore", - "structure", + "background", + "single", + "differences", + "three", + "results", + "bridge", + "model", + "protein", + "salt", + "tendency", + "changes", + "stabilization", "networks", - "predict", - "formed", + "novo", + "major", + "two", + "crystal", + "effects", + "similarities", "parental", - "proteins", "similar", - "de", - "similarities", - "variants", - "dependence", - "clusters", - "influence", - "highly", - "difficult", - "destabilizing", - "differently", - "structures", - "modifying", - "three", "either", - "exhibit", - "effects", - "properties", - "stability", - "salt", - "changes", + "conformational", + "formed", + "stabilizing", + "influence", + "effect", "bridges", - "among", - "engineering", - "observed", + "disulfide", + "depending", + "stability", + "destabilizing", + "proteins", + "highly", + "predict", + "since", + "features", "introduced", + "barrel", + "geometries", + "exhibit", "design", - "model", - "comparison", - "hydrophobic", "context", - "effect", - "high", + "work", + "different", + "environment", + "clusters", + "properties", + "rosetta", + "fold", "good", - "disulfide", - "structural", + "third", + "prediction", + "explore", + "modifying", + "modeling", + "dependence", + "analysis", + "differently", + "variants", + "observed", + "structures", + "de", + "structure", + "thermostability", "important", + "among", + "cluster", + "high", + "difficult", + "cores", "tim", - "stabilization", - "depending", - "designs", "despite", - "conformational", - "tendency", + "challenge", + "designs", + "ordered", "barrels", - "novo", - "single", - "barrel", - "rosetta", - "fold", - "different", - "two", - "explore", - "cores", - "protein", - "differences", - "third", - "environment", - "major", - "since" + "comparison" ], "release_date":"2021-12-15", "publication":"\"A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels\", Protein Sci., 31, 513-527", @@ -472650,11 +474636,11 @@ }, { "sim":346.0, - "partner":"7ot7" + "partner":"7osu" }, { "sim":346.0, - "partner":"7osu" + "partner":"7ot7" }, { "sim":341.0, @@ -472778,94 +474764,94 @@ ], "subtitle":"Stim11nocys-sb, a de novo designed tim barrel with a salt-bridge cluster (crystal form 2)", "tags":[ - "salt bridge cluster", + "tim barrel", "de novo protein", - "tim barrel" + "salt bridge cluster" ], "keywords":[ - "work", - "analysis", - "ordered", - "results", - "background", - "bridge", - "stabilizing", - "thermostability", - "challenge", - "cluster", - "geometries", - "prediction", - "crystal", - "modeling", - "features", + "engineering", + "hydrophobic", + "structural", "show", "therefore", - "structure", + "background", + "single", + "differences", + "three", + "results", + "bridge", + "model", + "protein", + "salt", + "tendency", + "changes", + "stabilization", "networks", - "predict", - "formed", + "novo", + "major", + "two", + "crystal", + "effects", + "similarities", "parental", - "proteins", "similar", - "de", - "similarities", - "variants", - "dependence", - "clusters", - "influence", - "highly", - "difficult", - "destabilizing", - "differently", - "structures", - "modifying", - "three", "either", - "exhibit", - "effects", - "properties", - "stability", - "salt", - "changes", + "conformational", + "formed", + "stabilizing", + "influence", + "effect", "bridges", - "among", - "engineering", - "observed", + "disulfide", + "depending", + "stability", + "destabilizing", + "proteins", + "highly", + "predict", + "since", + "features", "introduced", + "barrel", + "geometries", + "exhibit", "design", - "model", - "comparison", - "hydrophobic", "context", - "effect", - "high", + "work", + "different", + "environment", + "clusters", + "properties", + "rosetta", + "fold", "good", - "disulfide", - "structural", + "third", + "prediction", + "explore", + "modifying", + "modeling", + "dependence", + "analysis", + "differently", + "variants", + "observed", + "structures", + "de", + "structure", + "thermostability", "important", + "among", + "cluster", + "high", + "difficult", + "cores", "tim", - "stabilization", - "depending", - "designs", "despite", - "conformational", - "tendency", + "challenge", + "designs", + "ordered", "barrels", - "novo", - "single", - "barrel", - "rosetta", - "fold", - "different", - "two", - "explore", - "cores", - "protein", - "differences", - "third", - "environment", - "major", - "since" + "comparison" ], "release_date":"2021-12-15", "publication":"\"A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels\", Protein Sci., 31, 513-527", @@ -473029,94 +475015,94 @@ ], "subtitle":"Denovotim6-sb, a de novo designed tim barrel with a salt-bridge cluster (crystal form 2)", "tags":[ - "salt bridge cluster", + "tim barrel", "de novo protein", - "tim barrel" + "salt bridge cluster" ], "keywords":[ - "work", - "analysis", - "ordered", - "results", - "background", - "bridge", - "stabilizing", - "thermostability", - "challenge", - "cluster", - "geometries", - "prediction", - "crystal", - "modeling", - "features", + "engineering", + "hydrophobic", + "structural", "show", "therefore", - "structure", + "background", + "single", + "differences", + "three", + "results", + "bridge", + "model", + "protein", + "salt", + "tendency", + "changes", + "stabilization", "networks", - "predict", - "formed", + "novo", + "major", + "two", + "crystal", + "effects", + "similarities", "parental", - "proteins", "similar", - "de", - "similarities", - "variants", - "dependence", - "clusters", - "influence", - "highly", - "difficult", - "destabilizing", - "differently", - "structures", - "modifying", - "three", "either", - "exhibit", - "effects", - "properties", - "stability", - "salt", - "changes", + "conformational", + "formed", + "stabilizing", + "influence", + "effect", "bridges", - "among", - "engineering", - "observed", + "disulfide", + "depending", + "stability", + "destabilizing", + "proteins", + "highly", + "predict", + "since", + "features", "introduced", + "barrel", + "geometries", + "exhibit", "design", - "model", - "comparison", - "hydrophobic", "context", - "effect", - "high", + "work", + "different", + "environment", + "clusters", + "properties", + "rosetta", + "fold", "good", - "disulfide", - "structural", + "third", + "prediction", + "explore", + "modifying", + "modeling", + "dependence", + "analysis", + "differently", + "variants", + "observed", + "structures", + "de", + "structure", + "thermostability", "important", + "among", + "cluster", + "high", + "difficult", + "cores", "tim", - "stabilization", - "depending", - "designs", "despite", - "conformational", - "tendency", + "challenge", + "designs", + "ordered", "barrels", - "novo", - "single", - "barrel", - "rosetta", - "fold", - "different", - "two", - "explore", - "cores", - "protein", - "differences", - "third", - "environment", - "major", - "since" + "comparison" ], "release_date":"2021-12-15", "publication":"\"A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels\", Protein Sci., 31, 513-527", @@ -473157,11 +475143,11 @@ }, { "sim":346.0, - "partner":"7ot7" + "partner":"7osu" }, { "sim":346.0, - "partner":"7osu" + "partner":"7ot7" }, { "sim":341.0, @@ -473293,15 +475279,15 @@ ], "subtitle":"The hybrid cage formed between pizza6-s and cu(ii)-substituted trilacunary keggin", "tags":[ + "pom", + "biosynthetic protein", + "polyoxometalate", + "cu", "hybrid", "designer protein", - "keggin", - "biosynthetic protein", "protein design", - "cage", - "pom", - "polyoxometalate", - "cu" + "keggin", + "cage" ], "keywords":[ "description", @@ -473338,23 +475324,23 @@ "seq_thr_sim_designed":[ { "sim":503.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":503.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":503.0, - "partner":"6rei" + "partner":"6qse" }, { "sim":503.0, - "partner":"6qsf" + "partner":"6reg" }, { "sim":503.0, - "partner":"6reh" + "partner":"6qsf" }, { "sim":503.0, @@ -473362,11 +475348,11 @@ }, { "sim":503.0, - "partner":"6qsd" + "partner":"6qsh" }, { "sim":503.0, - "partner":"6qse" + "partner":"6qsd" }, { "sim":498.0, @@ -473374,15 +475360,15 @@ }, { "sim":498.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":498.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":498.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":498.0, @@ -473426,11 +475412,11 @@ }, { "sim":473.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":473.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":473.0, @@ -473438,7 +475424,7 @@ }, { "sim":473.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":467.0, @@ -473466,11 +475452,11 @@ }, { "sim":166.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":166.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":165.0, @@ -473484,11 +475470,11 @@ "seq_thr_sim_natural":[ { "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":340.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":94.0, @@ -473608,11 +475594,11 @@ }, { "sim":51.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":51.0, - "partner":"3sov" + "partner":"3soq" }, { "sim":51.0, @@ -473625,37 +475611,65 @@ ], "struct_thr_sim_designed":[ { - "sim":0.9854000211, - "partner":"7zpw" + "sim":0.9768000245, + "partner":"6qse" + }, + { + "sim":0.9811000228, + "partner":"6reh" + }, + { + "sim":0.970600009, + "partner":"6reo" }, { "sim":0.983099997, "partner":"6rei" }, { - "sim":0.9824000001, - "partner":"6reg" + "sim":0.9810000062, + "partner":"6rli" }, { - "sim":0.9811000228, - "partner":"6reh" + "sim":0.9824000001, + "partner":"6reg" }, { - "sim":0.9677000046, - "partner":"6rel" + "sim":0.9854000211, + "partner":"7zpw" }, { "sim":0.9854999781, "partner":"6qsg" }, { - "sim":0.9642999768, - "partner":"6qsd" + "sim":0.950699985, + "partner":"6f0s" + }, + { + "sim":0.956799984, + "partner":"6qsf" + }, + { + "sim":0.9661999941, + "partner":"7zpz" + }, + { + "sim":0.9677000046, + "partner":"6rel" }, { "sim":0.9587000012, "partner":"6rem" }, + { + "sim":0.969900012, + "partner":"6rlh" + }, + { + "sim":0.9642999768, + "partner":"6qsd" + }, { "sim":0.9569000006, "partner":"6f0t" @@ -473668,41 +475682,13 @@ "sim":0.9584000111, "partner":"3wwa" }, - { - "sim":0.9768000245, - "partner":"6qse" - }, { "sim":0.9587000012, "partner":"3ww9" }, - { - "sim":0.970600009, - "partner":"6reo" - }, - { - "sim":0.9661999941, - "partner":"7zpz" - }, - { - "sim":0.9810000062, - "partner":"6rli" - }, { "sim":0.9624000192, "partner":"7zqg" - }, - { - "sim":0.969900012, - "partner":"6rlh" - }, - { - "sim":0.950699985, - "partner":"6f0s" - }, - { - "sim":0.956799984, - "partner":"6qsf" } ], "struct_thr_sim_natural":[ @@ -473710,11 +475696,11 @@ ], "seq_max_sim_designed":{ "sim":503.0, - "partner":"6qsh" + "partner":"6rei" }, "seq_max_sim_natural":{ "sim":340.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9854999781, @@ -473768,94 +475754,94 @@ ], "subtitle":"Denovotim13-sb, a de novo designed tim barrel with a salt-bridge cluster", "tags":[ - "salt bridge cluster", + "tim barrel", "de novo protein", - "tim barrel" + "salt bridge cluster" ], "keywords":[ - "work", - "analysis", - "ordered", - "results", - "background", - "bridge", - "stabilizing", - "thermostability", - "challenge", - "cluster", - "geometries", - "prediction", - "crystal", - "modeling", - "features", + "engineering", + "hydrophobic", + "structural", "show", "therefore", - "structure", + "background", + "single", + "differences", + "three", + "results", + "bridge", + "model", + "protein", + "salt", + "tendency", + "changes", + "stabilization", "networks", - "predict", - "formed", + "novo", + "major", + "two", + "crystal", + "effects", + "similarities", "parental", - "proteins", "similar", - "de", - "similarities", - "variants", - "dependence", - "clusters", - "influence", - "highly", - "difficult", - "destabilizing", - "differently", - "structures", - "modifying", - "three", "either", - "exhibit", - "effects", - "properties", - "stability", - "salt", - "changes", + "conformational", + "formed", + "stabilizing", + "influence", + "effect", "bridges", - "among", - "engineering", - "observed", + "disulfide", + "depending", + "stability", + "destabilizing", + "proteins", + "highly", + "predict", + "since", + "features", "introduced", + "barrel", + "geometries", + "exhibit", "design", - "model", - "comparison", - "hydrophobic", "context", - "effect", - "high", + "work", + "different", + "environment", + "clusters", + "properties", + "rosetta", + "fold", "good", - "disulfide", - "structural", + "third", + "prediction", + "explore", + "modifying", + "modeling", + "dependence", + "analysis", + "differently", + "variants", + "observed", + "structures", + "de", + "structure", + "thermostability", "important", + "among", + "cluster", + "high", + "difficult", + "cores", "tim", - "stabilization", - "depending", - "designs", "despite", - "conformational", - "tendency", + "challenge", + "designs", + "ordered", "barrels", - "novo", - "single", - "barrel", - "rosetta", - "fold", - "different", - "two", - "explore", - "cores", - "protein", - "differences", - "third", - "environment", - "major", - "since" + "comparison" ], "release_date":"2021-12-15", "publication":"\"A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels\", Protein Sci., 31, 513-527", @@ -473908,11 +475894,11 @@ }, { "sim":267.0, - "partner":"7ot7" + "partner":"7osu" }, { "sim":267.0, - "partner":"7osu" + "partner":"7ot7" }, { "sim":262.0, @@ -473968,10 +475954,9 @@ "sim":374.0, "partner":"6yqx" }, - "seq_max_sim_natural":{ - "sim":44.0, - "partner":"2w6r" - }, + "seq_max_sim_natural":[ + + ], "struct_max_sim_designed":{ "sim":0.9108999968, "partner":"6yqx" @@ -474032,12 +476017,12 @@ ], "subtitle":"Crystal structure of the sake6bc designer protein", "tags":[ - "layer", - "beta propeller", + "self-assembly", + "designer", "synthetic", "unknown function", - "designer", - "self-assembly" + "beta propeller", + "layer" ], "keywords":[ "description", @@ -474098,11 +476083,11 @@ }, { "sim":479.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":479.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":479.0, @@ -474214,10 +476199,6 @@ "sim":307.0, "partner":"6hws" }, - { - "sim":307.0, - "partner":"6rog" - }, { "sim":307.0, "partner":"4ifj" @@ -474232,23 +476213,23 @@ }, { "sim":307.0, - "partner":"7xm3" + "partner":"6rog" }, { "sim":307.0, - "partner":"7xm4" + "partner":"7xm2" }, { "sim":307.0, - "partner":"7xm5" + "partner":"7xm3" }, { "sim":307.0, - "partner":"7xm2" + "partner":"7xm4" }, { "sim":307.0, - "partner":"4l7d" + "partner":"7xm5" }, { "sim":307.0, @@ -474262,6 +476243,10 @@ "sim":307.0, "partner":"4n1b" }, + { + "sim":307.0, + "partner":"4l7d" + }, { "sim":307.0, "partner":"7k2h" @@ -474366,25 +476351,17 @@ "sim":304.0, "partner":"6zez" }, - { - "sim":304.0, - "partner":"5fnq" - }, { "sim":304.0, "partner":"6zf0" }, - { - "sim":304.0, - "partner":"5fnr" - }, { "sim":304.0, "partner":"6zf1" }, { "sim":304.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":304.0, @@ -474392,7 +476369,7 @@ }, { "sim":304.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":304.0, @@ -474400,19 +476377,23 @@ }, { "sim":304.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":304.0, "partner":"6zf4" }, + { + "sim":304.0, + "partner":"5fnt" + }, { "sim":304.0, "partner":"6zf5" }, { "sim":304.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":304.0, @@ -474422,6 +476403,10 @@ "sim":304.0, "partner":"6zf7" }, + { + "sim":304.0, + "partner":"5fzj" + }, { "sim":304.0, "partner":"6zf8" @@ -474432,11 +476417,11 @@ }, { "sim":304.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":304.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":304.0, @@ -474512,15 +476497,15 @@ }, { "sim":303.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":303.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":303.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":302.0, @@ -474578,10 +476563,6 @@ "sim":301.0, "partner":"7k2m" }, - { - "sim":301.0, - "partner":"7k2r" - }, { "sim":301.0, "partner":"7k28" @@ -474608,7 +476589,7 @@ }, { "sim":301.0, - "partner":"7q5h" + "partner":"7k2r" }, { "sim":301.0, @@ -474632,7 +476613,7 @@ }, { "sim":301.0, - "partner":"7k2g" + "partner":"7q5h" }, { "sim":301.0, @@ -474658,6 +476639,10 @@ "sim":301.0, "partner":"7k2e" }, + { + "sim":301.0, + "partner":"7k2g" + }, { "sim":294.0, "partner":"5yq4" @@ -474666,10 +476651,6 @@ "sim":294.0, "partner":"6gy5" }, - { - "sim":263.0, - "partner":"8rbh" - }, { "sim":263.0, "partner":"6v7o" @@ -474682,6 +476663,10 @@ "sim":263.0, "partner":"6ttk" }, + { + "sim":263.0, + "partner":"8rbh" + }, { "sim":260.0, "partner":"6hrl" @@ -474704,19 +476689,19 @@ }, { "sim":246.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":246.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":181.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":181.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":129.0, @@ -474888,81 +476873,81 @@ ], "subtitle":"De novo designed homo-dimeric antiparallel helices homomer-s", "tags":[ + "de novo", + "de novo protein", "associating peptides", "antiparallel homo-dimeric coiled-coil", - "protein design", - "de novo protein", - "de novo" + "protein design" ], "keywords":[ - "work", - "sites", - "biophysical", - "engaging", - "designs", - "delivery", - "demonstrated", - "efficiently", - "acidic", - "functional", - "proteins", - "cell", - "assemblies", - "approach", - "dna", - "complexes", - "de", - "novo", - "challenge", - "intracellular", - "crystallography", + "organelles", "actively", - "peptide", - "including", - "fused", - "programmed", + "mammalian", + "design", "basic", - "localisation", + "subcellular", + "intracellular", + "principles", + "work", + "characterised", + "provides", "interest", - "complementary", - "comprises", + "de", + "therefore", + "functional", + "action", "methods", - "characterisation", - "vitro", - "system", - "provides", + "complexes", + "computationally", + "first", + "possible", + "dna", + "comprises", + "efficiently", + "targeting", + "synthetic", + "within", + "acidic", + "fused", + "delivery", + "new", "target", - "increasingly", - "design", - "action", - "introduced", - "binding", + "crystallography", "protein", - "synthetic", + "cell", + "biophysical", "bind", - "using", - "mammalian", - "characterised", - "therefore", + "approach", + "proteins", + "vitro", + "sites", + "characterisation", + "localisation", + "programmed", + "binding", + "utility", "routes", - "describe", - "deliver", - "computationally", - "penetration", - "within", - "organelles", - "principles", + "novo", + "much", "cells", - "first", "polypeptides", - "possible", - "much", + "engaging", + "system", + "demonstrated", + "increasingly", + "penetration", "developed", - "subcellular", + "deliver", + "describe", + "assemblies", + "designs", + "challenge", + "introduced", + "complementary", "marking", - "utility", - "targeting", - "new" + "using", + "including", + "peptide" ], "release_date":"2022-07-20", "publication":"\"De novo designed peptides for cellular delivery and subcellular localisation\", Nat.Chem.Biol., 18, 999-1004", @@ -475006,13 +476991,13 @@ "sim":0.9986000061, "partner":"7q1r" }, - { - "sim":0.9983999729, - "partner":"7q1s" - }, { "sim":0.9988999963, "partner":"7q1t" + }, + { + "sim":0.9983999729, + "partner":"7q1s" } ], "struct_thr_sim_natural":[ @@ -475096,83 +477081,83 @@ ], "subtitle":"A de novo designed homo-dimeric antiparallel coiled coil apcc-di", "tags":[ - "associating peptides", + "homo-dimeric", + "de novo", "antiparallel", - "coiled-coil", "de novo protein", - "protein design", - "de novo", - "homo-dimeric" + "associating peptides", + "coiled-coil", + "protein design" ], "keywords":[ - "work", - "sites", - "biophysical", - "engaging", - "designs", - "delivery", - "demonstrated", - "efficiently", - "acidic", - "functional", - "proteins", - "cell", - "assemblies", - "approach", - "dna", - "complexes", - "de", - "novo", - "challenge", - "intracellular", - "crystallography", + "organelles", "actively", - "peptide", - "including", - "fused", - "programmed", + "mammalian", + "design", "basic", - "localisation", + "subcellular", + "intracellular", + "principles", + "work", + "characterised", + "provides", "interest", - "complementary", - "comprises", + "de", + "therefore", + "functional", + "action", "methods", - "characterisation", - "vitro", - "system", - "provides", + "complexes", + "computationally", + "first", + "possible", + "dna", + "comprises", + "efficiently", + "targeting", + "synthetic", + "within", + "acidic", + "fused", + "delivery", + "new", "target", - "increasingly", - "design", - "action", - "introduced", - "binding", + "crystallography", "protein", - "synthetic", + "cell", + "biophysical", "bind", - "using", - "mammalian", - "characterised", - "therefore", + "approach", + "proteins", + "vitro", + "sites", + "characterisation", + "localisation", + "programmed", + "binding", + "utility", "routes", - "describe", - "deliver", - "computationally", - "penetration", - "within", - "organelles", - "principles", + "novo", + "much", "cells", - "first", "polypeptides", - "possible", - "much", + "engaging", + "system", + "demonstrated", + "increasingly", + "penetration", "developed", - "subcellular", + "deliver", + "describe", + "assemblies", + "designs", + "challenge", + "introduced", + "complementary", "marking", - "utility", - "targeting", - "new" + "using", + "including", + "peptide" ], "release_date":"2022-07-20", "publication":"\"De novo designed peptides for cellular delivery and subcellular localisation\", Nat.Chem.Biol., 18, 999-1004", @@ -475318,83 +477303,83 @@ ], "subtitle":"A de novo designed hetero-dimeric antiparallel coiled coil apcc-di-ab_var", "tags":[ - "associating peptides", + "de novo", "antiparallel", - "coiled-coil", "de novo protein", - "protein design", - "de novo", - "hetero-dimeric" + "hetero-dimeric", + "associating peptides", + "coiled-coil", + "protein design" ], "keywords":[ - "work", - "sites", - "biophysical", - "engaging", - "designs", - "delivery", - "demonstrated", - "efficiently", - "acidic", - "functional", - "proteins", - "cell", - "assemblies", - "approach", - "dna", - "complexes", - "de", - "novo", - "challenge", - "intracellular", - "crystallography", + "organelles", "actively", - "peptide", - "including", - "fused", - "programmed", + "mammalian", + "design", "basic", - "localisation", + "subcellular", + "intracellular", + "principles", + "work", + "characterised", + "provides", "interest", - "complementary", - "comprises", + "de", + "therefore", + "functional", + "action", "methods", - "characterisation", - "vitro", - "system", - "provides", + "complexes", + "computationally", + "first", + "possible", + "dna", + "comprises", + "efficiently", + "targeting", + "synthetic", + "within", + "acidic", + "fused", + "delivery", + "new", "target", - "increasingly", - "design", - "action", - "introduced", - "binding", + "crystallography", "protein", - "synthetic", + "cell", + "biophysical", "bind", - "using", - "mammalian", - "characterised", - "therefore", + "approach", + "proteins", + "vitro", + "sites", + "characterisation", + "localisation", + "programmed", + "binding", + "utility", "routes", - "describe", - "deliver", - "computationally", - "penetration", - "within", - "organelles", - "principles", + "novo", + "much", "cells", - "first", "polypeptides", - "possible", - "much", + "engaging", + "system", + "demonstrated", + "increasingly", + "penetration", "developed", - "subcellular", + "deliver", + "describe", + "assemblies", + "designs", + "challenge", + "introduced", + "complementary", "marking", - "utility", - "targeting", - "new" + "using", + "including", + "peptide" ], "release_date":"2022-07-20", "publication":"\"De novo designed peptides for cellular delivery and subcellular localisation\", Nat.Chem.Biol., 18, 999-1004", @@ -475436,11 +477421,11 @@ "struct_thr_sim_designed":[ { "sim":1.0, - "partner":"7q1r" + "partner":"7q1t" }, { "sim":1.0, - "partner":"7q1t" + "partner":"7q1r" }, { "sim":0.9983999729, @@ -475536,83 +477521,83 @@ ], "subtitle":"A de novo designed hetero-dimeric antiparallel coiled coil apcc-di-ab", "tags":[ - "associating peptides", + "de novo", "antiparallel", - "coiled-coil", "de novo protein", - "protein design", - "de novo", - "hetero-dimeric" + "hetero-dimeric", + "associating peptides", + "coiled-coil", + "protein design" ], "keywords":[ - "work", - "sites", - "biophysical", - "engaging", - "designs", - "delivery", - "demonstrated", - "efficiently", - "acidic", - "functional", - "proteins", - "cell", - "assemblies", - "approach", - "dna", - "complexes", - "de", - "novo", - "challenge", - "intracellular", - "crystallography", + "organelles", "actively", - "peptide", - "including", - "fused", - "programmed", + "mammalian", + "design", "basic", - "localisation", + "subcellular", + "intracellular", + "principles", + "work", + "characterised", + "provides", "interest", - "complementary", - "comprises", + "de", + "therefore", + "functional", + "action", "methods", - "characterisation", - "vitro", - "system", - "provides", + "complexes", + "computationally", + "first", + "possible", + "dna", + "comprises", + "efficiently", + "targeting", + "synthetic", + "within", + "acidic", + "fused", + "delivery", + "new", "target", - "increasingly", - "design", - "action", - "introduced", - "binding", + "crystallography", "protein", - "synthetic", + "cell", + "biophysical", "bind", - "using", - "mammalian", - "characterised", - "therefore", + "approach", + "proteins", + "vitro", + "sites", + "characterisation", + "localisation", + "programmed", + "binding", + "utility", "routes", - "describe", - "deliver", - "computationally", - "penetration", - "within", - "organelles", - "principles", + "novo", + "much", "cells", - "first", "polypeptides", - "possible", - "much", + "engaging", + "system", + "demonstrated", + "increasingly", + "penetration", "developed", - "subcellular", + "deliver", + "describe", + "assemblies", + "designs", + "challenge", + "introduced", + "complementary", "marking", - "utility", - "targeting", - "new" + "using", + "including", + "peptide" ], "release_date":"2022-07-20", "publication":"\"De novo designed peptides for cellular delivery and subcellular localisation\", Nat.Chem.Biol., 18, 999-1004", @@ -475651,11 +477636,11 @@ "struct_thr_sim_designed":[ { "sim":1.0, - "partner":"7q1r" + "partner":"7q1s" }, { "sim":1.0, - "partner":"7q1s" + "partner":"7q1r" }, { "sim":0.9988999963, @@ -475730,94 +477715,94 @@ ], "subtitle":"Computationally designed thioredoxin subjected to stability optimizing mutations", "tags":[ - "stability", - "screening", "deep mutational scanning", + "stability", + "de novo protein", "de-novo protein design", - "de novo protein" + "screening" ], "keywords":[ - "analysis", - "unfolding", - "gene", - "genetic", - "selection", - "acid", - "randomly", - "determine", - "substitutions", - "mutations", - "mutation", - "crystal", - "gmma", + "engineering", + "redesign", + "capability", + "single", "closer", - "structure", "sensor", - "redesign", - "computationally", - "screen", - "illustrates", - "even", - "limit", + "substitutions", "combining", - "proteins", - "redesigned", - "reached", - "variants", - "374", + "illustrates", + "randomly", + "acid", + "folding", + "model", + "protein", + "perturbations", + "study", + "increased", + "unfolding", + "showed", + "912", + "systems", + "crystal", + "stable", + "global", + "effects", + "mutated", + "helices", + "using", + "screened", "top", - "small", - "highly", - "rendered", + "computationally", "step", - "structures", + "gene", + "effect", "inform", - "showed", - "function", - "47", - "demonstration", - "effects", - "systems", - "capability", + "library", + "case", "stability", - "amino", - "template", - "increased", - "1", - "method", + "proteins", + "2", + "highly", + "small", + "conventional", + "reached", "mutant", - "9", - "screened", - "engineering", - "model", - "assigned", - "using", - "effect", - "high", - "stabilized", - "energy", + "computational", + "1", "increase", - "912", - "conventional", - "library", - "helices", - "applicable", - "study", - "stable", - "single", + "energy", + "374", + "redesigned", + "selection", + "even", + "possible", "apply", - "frequency", - "protein", - "mutated", - "2", + "template", + "amino", + "applicable", + "9", + "limit", "69", - "computational", + "frequency", + "determine", + "method", + "mutation", + "rendered", + "analysis", "vivo", - "global", - "folding", - "possible", - "case", - "perturbations" + "mutations", + "variants", + "structures", + "screen", + "structure", + "demonstration", + "function", + "assigned", + "gmma", + "high", + "genetic", + "47", + "stabilized" ], "release_date":"2022-11-16", "publication":"\"Increasing protein stability by inferring substitution effects from high-throughput experiments\", Cell Rep Methods, 2, 100333-100333", @@ -475888,11 +477873,11 @@ }, { "sim":63.0, - "partner":"2yj7" + "partner":"4ba7" }, { "sim":63.0, - "partner":"4ba7" + "partner":"2yj7" }, { "sim":61.0, @@ -475978,10 +477963,6 @@ "sim":56.0, "partner":"6h7m" }, - { - "sim":55.0, - "partner":"1tk5" - }, { "sim":55.0, "partner":"1sl0" @@ -476064,15 +478045,15 @@ }, { "sim":55.0, - "partner":"1f6m" + "partner":"1keb" }, { "sim":55.0, - "partner":"1keb" + "partner":"1tkd" }, { "sim":55.0, - "partner":"1tkd" + "partner":"1f6m" }, { "sim":55.0, @@ -476088,7 +478069,7 @@ }, { "sim":55.0, - "partner":"6yev" + "partner":"1tk5" }, { "sim":55.0, @@ -476100,16 +478081,20 @@ }, { "sim":55.0, - "partner":"5hr1" + "partner":"6n7w" }, { "sim":55.0, - "partner":"6n7w" + "partner":"5hr1" }, { "sim":55.0, "partner":"5hr3" }, + { + "sim":55.0, + "partner":"6yev" + }, { "sim":55.0, "partner":"8s2n" @@ -476124,11 +478109,11 @@ }, { "sim":55.0, - "partner":"7scd" + "partner":"7sce" }, { "sim":55.0, - "partner":"7sce" + "partner":"7scd" }, { "sim":55.0, @@ -476180,11 +478165,11 @@ }, { "sim":54.0, - "partner":"6nup" + "partner":"6mza" }, { "sim":54.0, - "partner":"6mza" + "partner":"6nup" }, { "sim":54.0, @@ -476204,15 +478189,15 @@ }, { "sim":54.0, - "partner":"6y4y" + "partner":"6y4z" }, { "sim":54.0, - "partner":"6y4z" + "partner":"6y73" }, { "sim":54.0, - "partner":"6y73" + "partner":"6y4y" }, { "sim":54.0, @@ -476345,94 +478330,94 @@ ], "subtitle":"Computationally designed thioredoxin subjected to stability optimizing mutations", "tags":[ - "stability", - "screening", "deep mutational scanning", + "stability", + "de novo protein", "de-novo protein design", - "de novo protein" + "screening" ], "keywords":[ - "analysis", - "unfolding", - "gene", - "genetic", - "selection", - "acid", - "randomly", - "determine", - "substitutions", - "mutations", - "mutation", - "crystal", - "gmma", + "engineering", + "redesign", + "capability", + "single", "closer", - "structure", "sensor", - "redesign", - "computationally", - "screen", - "illustrates", - "even", - "limit", + "substitutions", "combining", - "proteins", - "redesigned", - "reached", - "variants", - "374", + "illustrates", + "randomly", + "acid", + "folding", + "model", + "protein", + "perturbations", + "study", + "increased", + "unfolding", + "showed", + "912", + "systems", + "crystal", + "stable", + "global", + "effects", + "mutated", + "helices", + "using", + "screened", "top", - "small", - "highly", - "rendered", + "computationally", "step", - "structures", + "gene", + "effect", "inform", - "showed", - "function", - "47", - "demonstration", - "effects", - "systems", - "capability", + "library", + "case", "stability", - "amino", - "template", - "increased", - "1", - "method", + "proteins", + "2", + "highly", + "small", + "conventional", + "reached", "mutant", - "9", - "screened", - "engineering", - "model", - "assigned", - "using", - "effect", - "high", - "stabilized", - "energy", + "computational", + "1", "increase", - "912", - "conventional", - "library", - "helices", - "applicable", - "study", - "stable", - "single", + "energy", + "374", + "redesigned", + "selection", + "even", + "possible", "apply", - "frequency", - "protein", - "mutated", - "2", + "template", + "amino", + "applicable", + "9", + "limit", "69", - "computational", + "frequency", + "determine", + "method", + "mutation", + "rendered", + "analysis", "vivo", - "global", - "folding", - "possible", - "case", - "perturbations" + "mutations", + "variants", + "structures", + "screen", + "structure", + "demonstration", + "function", + "assigned", + "gmma", + "high", + "genetic", + "47", + "stabilized" ], "release_date":"2022-11-16", "publication":"\"Increasing protein stability by inferring substitution effects from high-throughput experiments\", Cell Rep Methods, 2, 100333-100333", @@ -476553,10 +478538,6 @@ "sim":59.0, "partner":"5ikn" }, - { - "sim":59.0, - "partner":"1tk5" - }, { "sim":59.0, "partner":"1sl0" @@ -476671,7 +478652,7 @@ }, { "sim":59.0, - "partner":"6yev" + "partner":"1tk5" }, { "sim":59.0, @@ -476681,13 +478662,17 @@ "sim":59.0, "partner":"6p7e" }, + { + "sim":59.0, + "partner":"6h7o" + }, { "sim":59.0, "partner":"5e4w" }, { "sim":59.0, - "partner":"6h7o" + "partner":"6n7w" }, { "sim":59.0, @@ -476695,11 +478680,11 @@ }, { "sim":59.0, - "partner":"6n7w" + "partner":"6h7j" }, { "sim":59.0, - "partner":"6h7j" + "partner":"6h7l" }, { "sim":59.0, @@ -476707,11 +478692,11 @@ }, { "sim":59.0, - "partner":"6h7l" + "partner":"6h7m" }, { "sim":59.0, - "partner":"6h7m" + "partner":"6yev" }, { "sim":59.0, @@ -476719,11 +478704,11 @@ }, { "sim":59.0, - "partner":"7scd" + "partner":"7sce" }, { "sim":59.0, - "partner":"7sce" + "partner":"7scd" }, { "sim":59.0, @@ -476739,11 +478724,11 @@ }, { "sim":58.0, - "partner":"1f6m" + "partner":"2eir" }, { "sim":58.0, - "partner":"2eir" + "partner":"1f6m" }, { "sim":58.0, @@ -476751,11 +478736,11 @@ }, { "sim":58.0, - "partner":"6nup" + "partner":"6mza" }, { "sim":58.0, - "partner":"6mza" + "partner":"6nup" }, { "sim":58.0, @@ -476779,15 +478764,15 @@ }, { "sim":58.0, - "partner":"6y4y" + "partner":"6y4z" }, { "sim":58.0, - "partner":"6y4z" + "partner":"6y73" }, { "sim":58.0, - "partner":"6y73" + "partner":"6y4y" }, { "sim":58.0, @@ -476984,12 +478969,12 @@ ], "subtitle":"Crystal structure of the sake6br designer protein", "tags":[ - "layer", - "beta propeller", + "self-assembly", + "designer", "synthetic", "unknown function", - "designer", - "self-assembly" + "beta propeller", + "layer" ], "keywords":[ "description", @@ -477042,11 +479027,11 @@ }, { "sim":467.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":467.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":467.0, @@ -477116,19 +479101,19 @@ "seq_thr_sim_natural":[ { "sim":316.0, - "partner":"7xm3" + "partner":"7xm2" }, { "sim":316.0, - "partner":"7xm4" + "partner":"7xm3" }, { "sim":316.0, - "partner":"7xm5" + "partner":"7xm4" }, { "sim":316.0, - "partner":"7xm2" + "partner":"7xm5" }, { "sim":316.0, @@ -477162,10 +479147,6 @@ "sim":316.0, "partner":"3vnh" }, - { - "sim":315.0, - "partner":"4l7d" - }, { "sim":315.0, "partner":"4l7b" @@ -477178,6 +479159,10 @@ "sim":315.0, "partner":"4n1b" }, + { + "sim":315.0, + "partner":"4l7d" + }, { "sim":315.0, "partner":"7k2f" @@ -477196,23 +479181,23 @@ }, { "sim":314.0, - "partner":"5x54" + "partner":"4ifj" }, { "sim":314.0, - "partner":"6rog" + "partner":"4ifl" }, { "sim":314.0, - "partner":"4ifj" + "partner":"4ifn" }, { "sim":314.0, - "partner":"4ifl" + "partner":"5x54" }, { "sim":314.0, - "partner":"4ifn" + "partner":"6rog" }, { "sim":314.0, @@ -477334,25 +479319,17 @@ "sim":312.0, "partner":"6zez" }, - { - "sim":312.0, - "partner":"5fnq" - }, { "sim":312.0, "partner":"6zf0" }, - { - "sim":312.0, - "partner":"5fnr" - }, { "sim":312.0, "partner":"6zf1" }, { "sim":312.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":312.0, @@ -477360,7 +479337,7 @@ }, { "sim":312.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":312.0, @@ -477368,19 +479345,23 @@ }, { "sim":312.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":312.0, "partner":"6zf4" }, + { + "sim":312.0, + "partner":"5fnt" + }, { "sim":312.0, "partner":"6zf5" }, { "sim":312.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":312.0, @@ -477390,6 +479371,10 @@ "sim":312.0, "partner":"6zf7" }, + { + "sim":312.0, + "partner":"5fzj" + }, { "sim":312.0, "partner":"6zf8" @@ -477408,11 +479393,11 @@ }, { "sim":312.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":312.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":312.0, @@ -477488,15 +479473,15 @@ }, { "sim":310.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":310.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":310.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":310.0, @@ -477522,10 +479507,6 @@ "sim":310.0, "partner":"5wfl" }, - { - "sim":309.0, - "partner":"7k2r" - }, { "sim":309.0, "partner":"7k28" @@ -477552,7 +479533,7 @@ }, { "sim":309.0, - "partner":"7q5h" + "partner":"7k2r" }, { "sim":309.0, @@ -477576,7 +479557,7 @@ }, { "sim":309.0, - "partner":"7k2g" + "partner":"7q5h" }, { "sim":309.0, @@ -477602,6 +479583,10 @@ "sim":309.0, "partner":"7k2e" }, + { + "sim":309.0, + "partner":"7k2g" + }, { "sim":306.0, "partner":"7k2l" @@ -477624,11 +479609,11 @@ }, { "sim":258.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":258.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":248.0, @@ -477646,10 +479631,6 @@ "sim":245.0, "partner":"5nkp" }, - { - "sim":239.0, - "partner":"8rbh" - }, { "sim":239.0, "partner":"6v7o" @@ -477663,13 +479644,17 @@ "partner":"6ttk" }, { - "sim":154.0, - "partner":"4yy8" + "sim":239.0, + "partner":"8rbh" }, { "sim":154.0, "partner":"4zgc" }, + { + "sim":154.0, + "partner":"4yy8" + }, { "sim":128.0, "partner":"3ii7" @@ -477742,7 +479727,7 @@ }, "seq_max_sim_natural":{ "sim":316.0, - "partner":"7xm3" + "partner":"7xm2" }, "struct_max_sim_designed":{ "sim":0.9690999985, @@ -477802,95 +479787,95 @@ "octamer" ], "keywords":[ - "work", - "stabilizing", - "frequently", - "acid", - "peptide", - "near", - "uses", - "crystal", - "exist", + "repeats", + "open", + "engineering", + "hydrophobic", + "structural", + "iterations", "show", - "features", - "rarely", - "interactions", - "synthetic", - "designing", - "consolidated", - "structure", - "unexplored", - "pack", - "principles", - "quaternary", - "tendencies", - "conformations", - "tend", - "built", + "acid", + "mean", + "folding", + "protein", + "six", "5", - "proteins", - "although", - "point", - "less", - "open", - "nature", - "3", - "structures", + "helical", + "incorporates", + "informed", + "region", "exceed", - "widely", - "natural", - "tertiary", - "biology", - "form", + "crystal", "rules", - "much", - "iterations", - "assemblies", - "report", - "bundles", - "energies", - "analysing", - "identify", - "1", - "4", "10", - "region", + "tertiary", + "conformational", + "bundles", + "supersecondary", + "stabilizing", + "opportunities", + "residues", + "hitherto", + "although", + "widely", + "quaternary", + "occur", + "favourable", "tipping", - "engineering", - "six", - "informed", - "provides", - "design", + "proteins", "characterization", - "incorporates", - "reduced", - "helical", - "occur", - "hydrophobic", + "2", + "energies", + "features", "required", - "favourable", - "repeats", - "exploited", - "hitherto", - "known", - "structural", - "despite", - "conformational", - "rational", + "1", + "peptide", + "normal", + "tend", + "designing", + "design", + "unexplored", "length", - "residues", - "reveal", - "supersecondary", + "work", + "principles", + "provides", + "biology", + "natural", "absence", - "normal", - "cores", - "protein", - "2", + "consolidated", + "point", + "reduced", + "uses", + "near", + "assemblies", + "exist", + "reveal", + "form", + "pack", + "analysing", "space", - "mean", - "folding", + "structures", + "built", + "rational", + "3", + "structure", + "synthetic", + "report", + "frequently", + "interactions", + "nature", + "known", + "4", "internal", - "opportunities" + "rarely", + "tendencies", + "identify", + "much", + "cores", + "conformations", + "despite", + "exploited", + "less" ], "release_date":"2022-04-27", "publication":"\"De novo design of discrete, stable 3 10 -helix peptide assemblies\", Nature, 607, 387-392", @@ -477993,95 +479978,95 @@ "alpha-helical" ], "keywords":[ - "work", - "stabilizing", - "frequently", - "acid", - "peptide", - "near", - "uses", - "crystal", - "exist", + "repeats", + "open", + "engineering", + "hydrophobic", + "structural", + "iterations", "show", - "features", - "rarely", - "interactions", - "synthetic", - "designing", - "consolidated", - "structure", - "unexplored", - "pack", - "principles", - "quaternary", - "tendencies", - "conformations", - "tend", - "built", + "acid", + "mean", + "folding", + "protein", + "six", "5", - "proteins", - "although", - "point", - "less", - "open", - "nature", - "3", - "structures", + "helical", + "incorporates", + "informed", + "region", "exceed", - "widely", - "natural", - "tertiary", - "biology", - "form", + "crystal", "rules", - "much", - "iterations", - "assemblies", - "report", - "bundles", - "energies", - "analysing", - "identify", - "1", - "4", "10", - "region", + "tertiary", + "conformational", + "bundles", + "supersecondary", + "stabilizing", + "opportunities", + "residues", + "hitherto", + "although", + "widely", + "quaternary", + "occur", + "favourable", "tipping", - "engineering", - "six", - "informed", - "provides", - "design", + "proteins", "characterization", - "incorporates", - "reduced", - "helical", - "occur", - "hydrophobic", + "2", + "energies", + "features", "required", - "favourable", - "repeats", - "exploited", - "hitherto", - "known", - "structural", - "despite", - "conformational", - "rational", + "1", + "peptide", + "normal", + "tend", + "designing", + "design", + "unexplored", "length", - "residues", - "reveal", - "supersecondary", + "work", + "principles", + "provides", + "biology", + "natural", "absence", - "normal", - "cores", - "protein", - "2", + "consolidated", + "point", + "reduced", + "uses", + "near", + "assemblies", + "exist", + "reveal", + "form", + "pack", + "analysing", "space", - "mean", - "folding", + "structures", + "built", + "rational", + "3", + "structure", + "synthetic", + "report", + "frequently", + "interactions", + "nature", + "known", + "4", "internal", - "opportunities" + "rarely", + "tendencies", + "identify", + "much", + "cores", + "conformations", + "despite", + "exploited", + "less" ], "release_date":"2022-04-27", "publication":"\"De novo design of discrete, stable 3 10 -helix peptide assemblies\", Nature, 607, 387-392", @@ -478182,99 +480167,99 @@ "subtitle":"A trimeric de novo coiled-coil assembly: cc-typen-lald", "tags":[ "de novo protein", - "alpha-helical", - "ll core" + "ll core", + "alpha-helical" ], "keywords":[ - "work", - "stabilizing", - "frequently", - "acid", - "peptide", - "near", - "uses", - "crystal", - "exist", + "repeats", + "open", + "engineering", + "hydrophobic", + "structural", + "iterations", "show", - "features", - "rarely", - "interactions", - "synthetic", - "designing", - "consolidated", - "structure", - "unexplored", - "pack", - "principles", - "quaternary", - "tendencies", - "conformations", - "tend", - "built", + "acid", + "mean", + "folding", + "protein", + "six", "5", - "proteins", - "although", - "point", - "less", - "open", - "nature", - "3", - "structures", + "helical", + "incorporates", + "informed", + "region", "exceed", - "widely", - "natural", - "tertiary", - "biology", - "form", + "crystal", "rules", - "much", - "iterations", - "assemblies", - "report", - "bundles", - "energies", - "analysing", - "identify", - "1", - "4", "10", - "region", + "tertiary", + "conformational", + "bundles", + "supersecondary", + "stabilizing", + "opportunities", + "residues", + "hitherto", + "although", + "widely", + "quaternary", + "occur", + "favourable", "tipping", - "engineering", - "six", - "informed", - "provides", - "design", + "proteins", "characterization", - "incorporates", - "reduced", - "helical", - "occur", - "hydrophobic", + "2", + "energies", + "features", "required", - "favourable", - "repeats", - "exploited", - "hitherto", - "known", - "structural", - "despite", - "conformational", - "rational", + "1", + "peptide", + "normal", + "tend", + "designing", + "design", + "unexplored", "length", - "residues", - "reveal", - "supersecondary", + "work", + "principles", + "provides", + "biology", + "natural", "absence", - "normal", - "cores", - "protein", - "2", + "consolidated", + "point", + "reduced", + "uses", + "near", + "assemblies", + "exist", + "reveal", + "form", + "pack", + "analysing", "space", - "mean", - "folding", + "structures", + "built", + "rational", + "3", + "structure", + "synthetic", + "report", + "frequently", + "interactions", + "nature", + "known", + "4", "internal", - "opportunities" + "rarely", + "tendencies", + "identify", + "much", + "cores", + "conformations", + "despite", + "exploited", + "less" ], "release_date":"2022-04-27", "publication":"\"De novo design of discrete, stable 3 10 -helix peptide assemblies\", Nature, 607, 387-392", @@ -478436,10 +480421,10 @@ ], "subtitle":"Lov2-darpin fusion - d4_deltalov", "tags":[ - "darpin", - "light switching", + "lov2 domain", "de novo protein", - "lov2 domain" + "light switching", + "darpin" ], "keywords":[ "description", @@ -478540,7 +480525,7 @@ }, { "sim":243.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":243.0, @@ -478548,7 +480533,7 @@ }, { "sim":243.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":242.0, @@ -478596,11 +480581,11 @@ }, { "sim":225.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":225.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":225.0, @@ -478612,11 +480597,11 @@ }, { "sim":221.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":221.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":220.0, @@ -478624,7 +480609,7 @@ }, { "sim":220.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":220.0, @@ -478632,15 +480617,15 @@ }, { "sim":220.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":220.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":220.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":220.0, @@ -478648,15 +480633,15 @@ }, { "sim":220.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":220.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":220.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":220.0, @@ -478664,23 +480649,23 @@ }, { "sim":220.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":220.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":220.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":220.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":220.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":220.0, @@ -478688,11 +480673,11 @@ }, { "sim":219.0, - "partner":"7dne" + "partner":"2xeh" }, { "sim":219.0, - "partner":"2xeh" + "partner":"7dne" }, { "sim":219.0, @@ -478776,11 +480761,11 @@ }, { "sim":174.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":174.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":171.0, @@ -478804,11 +480789,11 @@ }, { "sim":163.0, - "partner":"4gpm" + "partner":"4hb5" }, { "sim":163.0, - "partner":"4hb5" + "partner":"4gpm" }, { "sim":162.0, @@ -478834,6 +480819,10 @@ "sim":155.0, "partner":"5kba" }, + { + "sim":153.0, + "partner":"9glq" + }, { "sim":123.0, "partner":"2xen" @@ -478890,11 +480879,11 @@ }, { "sim":254.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":254.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":252.0, @@ -479036,45 +481025,25 @@ "sim":223.0, "partner":"4k5c" }, - { - "sim":222.0, - "partner":"5eno" - }, - { - "sim":222.0, - "partner":"6zob" - }, - { - "sim":222.0, - "partner":"6zo5" - }, { "sim":222.0, "partner":"4dx6" }, { "sim":222.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":222.0, "partner":"6zoc" }, - { - "sim":222.0, - "partner":"5enp" - }, - { - "sim":222.0, - "partner":"6sgs" - }, { "sim":222.0, "partner":"6zo6" }, { "sim":222.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":222.0, @@ -479082,7 +481051,7 @@ }, { "sim":222.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":222.0, @@ -479090,11 +481059,11 @@ }, { "sim":222.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":222.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":222.0, @@ -479106,31 +481075,31 @@ }, { "sim":222.0, - "partner":"6q4p" + "partner":"5enq" }, { "sim":222.0, - "partner":"6sgt" + "partner":"6q4p" }, { "sim":222.0, - "partner":"7ouk" + "partner":"6sgt" }, { "sim":222.0, - "partner":"2j8s" + "partner":"7b8s" }, { "sim":222.0, - "partner":"4u96" + "partner":"7ouk" }, { "sim":222.0, - "partner":"7b8s" + "partner":"2j8s" }, { "sim":222.0, - "partner":"3noc" + "partner":"4u96" }, { "sim":222.0, @@ -479142,15 +481111,15 @@ }, { "sim":222.0, - "partner":"5enr" + "partner":"3noc" }, { "sim":222.0, - "partner":"4u8v" + "partner":"6sgu" }, { "sim":222.0, - "partner":"6sgu" + "partner":"5enr" }, { "sim":222.0, @@ -479158,7 +481127,11 @@ }, { "sim":222.0, - "partner":"5nc5" + "partner":"4u8v" + }, + { + "sim":222.0, + "partner":"7b8t" }, { "sim":222.0, @@ -479170,15 +481143,15 @@ }, { "sim":222.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":222.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":222.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":222.0, @@ -479190,20 +481163,24 @@ }, { "sim":222.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":222.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":222.0, - "partner":"6zoh" + "partner":"4u8y" }, { "sim":222.0, "partner":"4hna" }, + { + "sim":222.0, + "partner":"6sgr" + }, { "sim":222.0, "partner":"4c48" @@ -479218,12 +481195,24 @@ }, { "sim":222.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":222.0, "partner":"4dx5" }, + { + "sim":222.0, + "partner":"5eno" + }, + { + "sim":222.0, + "partner":"6zo5" + }, + { + "sim":222.0, + "partner":"6q4n" + }, { "sim":222.0, "partner":"5mla" @@ -479246,11 +481235,11 @@ }, { "sim":220.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":220.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":220.0, @@ -479260,30 +481249,18 @@ "sim":220.0, "partner":"6bbn" }, - { - "sim":220.0, - "partner":"7yz0" - }, { "sim":220.0, "partner":"6mzf" }, { "sim":220.0, - "partner":"7yz1" - }, - { - "sim":220.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":220.0, "partner":"5nqt" }, - { - "sim":220.0, - "partner":"6mze" - }, { "sim":220.0, "partner":"7yz2" @@ -479294,11 +481271,11 @@ }, { "sim":220.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":220.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":220.0, @@ -479308,13 +481285,17 @@ "sim":220.0, "partner":"7yz5" }, + { + "sim":220.0, + "partner":"7yz6" + }, { "sim":220.0, "partner":"4lnu" }, { "sim":220.0, - "partner":"7yz6" + "partner":"6zwb" }, { "sim":220.0, @@ -479328,10 +481309,6 @@ "sim":220.0, "partner":"5nm5" }, - { - "sim":220.0, - "partner":"6zwb" - }, { "sim":220.0, "partner":"6zwc" @@ -479344,6 +481321,18 @@ "sim":220.0, "partner":"7yyz" }, + { + "sim":220.0, + "partner":"7yz0" + }, + { + "sim":220.0, + "partner":"7yz1" + }, + { + "sim":220.0, + "partner":"7z01" + }, { "sim":219.0, "partner":"6h46" @@ -479402,11 +481391,11 @@ }, { "sim":216.0, - "partner":"2y1l" + "partner":"6gvm" }, { "sim":216.0, - "partner":"6gvm" + "partner":"2y1l" }, { "sim":216.0, @@ -479428,10 +481417,6 @@ "sim":214.0, "partner":"5oov" }, - { - "sim":214.0, - "partner":"5oyj" - }, { "sim":214.0, "partner":"4ydy" @@ -479444,6 +481429,10 @@ "sim":214.0, "partner":"6gvn" }, + { + "sim":214.0, + "partner":"5oyj" + }, { "sim":213.0, "partner":"8dw2" @@ -479526,11 +481515,11 @@ }, { "sim":200.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":200.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":199.0, @@ -479542,11 +481531,11 @@ }, { "sim":188.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":188.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":188.0, @@ -479556,10 +481545,6 @@ "sim":187.0, "partner":"6ne4" }, - { - "sim":180.0, - "partner":"7pd8" - }, { "sim":180.0, "partner":"7pdd" @@ -479572,6 +481557,10 @@ "sim":180.0, "partner":"7pdh" }, + { + "sim":180.0, + "partner":"7pd8" + }, { "sim":180.0, "partner":"6ne1" @@ -479650,23 +481639,23 @@ }, { "sim":155.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":155.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":155.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":155.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":155.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":155.0, @@ -479674,11 +481663,11 @@ }, { "sim":155.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":155.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":155.0, @@ -479756,17 +481745,13 @@ "sim":128.0, "partner":"5aar" }, - { - "sim":125.0, - "partner":"4cym" - }, { "sim":125.0, "partner":"4cz2" }, { "sim":125.0, - "partner":"5vhj" + "partner":"4cym" }, { "sim":125.0, @@ -479798,15 +481783,15 @@ }, { "sim":125.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":125.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":125.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":125.0, @@ -479816,6 +481801,10 @@ "sim":125.0, "partner":"7vxw" }, + { + "sim":125.0, + "partner":"1uoh" + }, { "sim":125.0, "partner":"7vy4" @@ -479826,11 +481815,11 @@ }, { "sim":125.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":125.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":125.0, @@ -479950,11 +481939,11 @@ }, { "sim":108.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":108.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":108.0, @@ -480032,14 +482021,6 @@ "sim":102.0, "partner":"1ap7" }, - { - "sim":102.0, - "partner":"6m11" - }, - { - "sim":102.0, - "partner":"6m12" - }, { "sim":102.0, "partner":"6m13" @@ -480064,6 +482045,14 @@ "sim":102.0, "partner":"4o1p" }, + { + "sim":102.0, + "partner":"6m11" + }, + { + "sim":102.0, + "partner":"6m12" + }, { "sim":101.0, "partner":"3d9h" @@ -480108,10 +482097,6 @@ "sim":96.0, "partner":"6jd6" }, - { - "sim":96.0, - "partner":"6v9x" - }, { "sim":96.0, "partner":"6v9y" @@ -480124,6 +482109,10 @@ "sim":96.0, "partner":"6v9w" }, + { + "sim":96.0, + "partner":"6v9x" + }, { "sim":96.0, "partner":"7or0" @@ -480226,11 +482215,11 @@ }, { "sim":87.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":87.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":85.0, @@ -480262,31 +482251,31 @@ }, { "sim":77.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":77.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":77.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":77.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":76.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":76.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":76.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":76.0, @@ -480316,10 +482305,6 @@ "sim":73.0, "partner":"5wo6" }, - { - "sim":73.0, - "partner":"5iwr" - }, { "sim":73.0, "partner":"5iwt" @@ -480372,6 +482357,10 @@ "sim":73.0, "partner":"5iwp" }, + { + "sim":73.0, + "partner":"5iwr" + }, { "sim":73.0, "partner":"5wo7" @@ -480388,10 +482377,6 @@ "sim":72.0, "partner":"6iyb" }, - { - "sim":71.0, - "partner":"6o1p" - }, { "sim":71.0, "partner":"6b5v" @@ -480430,7 +482415,7 @@ }, { "sim":71.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":71.0, @@ -480464,6 +482449,10 @@ "sim":71.0, "partner":"7t6l" }, + { + "sim":71.0, + "partner":"7t6m" + }, { "sim":67.0, "partner":"8pef" @@ -480496,10 +482485,6 @@ "sim":66.0, "partner":"3ljn" }, - { - "sim":66.0, - "partner":"7k4a" - }, { "sim":66.0, "partner":"7k4b" @@ -480522,7 +482507,7 @@ }, { "sim":66.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":66.0, @@ -480538,7 +482523,7 @@ }, { "sim":66.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":66.0, @@ -480550,7 +482535,7 @@ }, { "sim":66.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":66.0, @@ -480568,6 +482553,10 @@ "sim":66.0, "partner":"6bo8" }, + { + "sim":66.0, + "partner":"6bo9" + }, { "sim":65.0, "partner":"4a63" @@ -480624,10 +482613,6 @@ "sim":59.0, "partner":"5is0" }, - { - "sim":59.0, - "partner":"7mzc" - }, { "sim":59.0, "partner":"7l2v" @@ -480690,7 +482675,7 @@ }, { "sim":59.0, - "partner":"7l2n" + "partner":"7mzc" }, { "sim":59.0, @@ -480726,20 +482711,16 @@ }, { "sim":59.0, - "partner":"7lpd" + "partner":"7l2n" }, { "sim":59.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":59.0, "partner":"7rqv" }, - { - "sim":59.0, - "partner":"7lpe" - }, { "sim":59.0, "partner":"7rqw" @@ -480772,17 +482753,25 @@ "sim":59.0, "partner":"7lpc" }, + { + "sim":59.0, + "partner":"7rqu" + }, + { + "sim":59.0, + "partner":"7lpd" + }, { "sim":58.0, "partner":"7us2" }, { "sim":58.0, - "partner":"7ttr" + "partner":"7tts" }, { "sim":58.0, - "partner":"7tts" + "partner":"7ttr" }, { "sim":57.0, @@ -480812,6 +482801,10 @@ "sim":53.0, "partner":"5h2c" }, + { + "sim":53.0, + "partner":"8ycp" + }, { "sim":53.0, "partner":"8gf8" @@ -480902,119 +482895,119 @@ "subtitle":"Designed armadillo repeat protein n(a4)m4c(aii) co-crystallized with hen egg white lysozyme", "tags":[ "armadillo", + "capping repeat", "hydrolase", "protein engineering", - "capping repeat", "repeat protein" ], "keywords":[ - "exchange", - "containing", - "remarkably", - "unfolding", - "aggregation", + "superior", + "repeats", + "recognition", + "optimized", + "hydrophobic", + "repeat", + "overcome", + "show", "orders", - "protect", + "core", + "new", + "protein", + "partially", + "increased", "biochemical", - "time", - "designed", - "basic", - "local", - "improved", - "experimentally", + "linear", + "flanked", + "binding", + "unfolding", + "subsequent", + "armrps", + "resonance", + "circular", + "composed", + "original", + "nuclear", "crystal", - "determined", - "correlates", - "show", - "software", - "overcome", - "enhanced", + "using", + "remarkably", "conformation", - "structure", - "repeat", + "starting", "computationally", + "experimentally", + "armadillo", + "overall", + "epitopes", + "aggregation", + "proteolysis", "weakened", - "instability", - "novel", - "starting", - "armrps", - "darmrp", - "composed", - "original", - "partially", + "level", + "magnetic", + "stability", "proteins", - "employed", - "models", - "impeded", - "linear", - "feature", - "resulting", + "packing", + "several", + "consensus", + "modular", + "hydrogen", "small", - "used", - "recognition", - "darmrps", - "nuclear", + "four", + "correlates", + "local", + "design", + "enhanced", "onto", + "spectroscopy", "therapeutics", - "assumes", - "flanked", - "capping", - "solution", - "resonance", - "armadillo", - "revealed", - "circular", + "used", + "feature", "research", - "magnitude", - "first", - "solvent", - "hydrogen", - "consensus", - "previously", - "stability", - "fraction", - "verified", - "subsequent", - "vulnerable", - "four", - "increased", - "mode", - "engineer", "application", - "several", - "design", - "core", + "rosetta", + "experiments", + "instability", + "vulnerable", "reduced", - "exposure", - "using", "resistance", - "hydrophobic", - "proteolysis", - "high", - "repeats", - "epitopes", - "packing", - "important", - "overall", - "magnetic", - "optimized", + "mode", + "improved", + "solution", "renders", - "experiments", - "rosetta", - "modular", - "spectroscopy", + "time", + "exchange", + "magnitude", "unfolded", - "problem", - "binding", - "protein", + "assumes", + "engineer", "refined", - "superior", - "diagnostics", - "dichroism", - "internal", + "designed", + "verified", + "employed", + "models", + "basic", + "revealed", + "first", + "previously", + "exposure", + "important", + "structure", + "determined", + "resulting", "biophysical", - "level", - "new" + "capping", + "impeded", + "darmrps", + "internal", + "software", + "high", + "fraction", + "dichroism", + "solvent", + "darmrp", + "protect", + "problem", + "containing", + "diagnostics", + "novel" ], "release_date":"2022-06-08", "publication":"\"Improved Repeat Protein Stability by Combined Consensus and Computational Protein Design\", Biochemistry, 62, 318-329", @@ -481051,11 +483044,11 @@ }, { "sim":426.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":426.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":426.0, @@ -481067,11 +483060,11 @@ }, { "sim":426.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":426.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":426.0, @@ -481087,11 +483080,11 @@ }, { "sim":416.0, - "partner":"6s9n" + "partner":"6s9m" }, { "sim":416.0, - "partner":"6s9m" + "partner":"6s9n" }, { "sim":413.0, @@ -481155,11 +483148,11 @@ }, { "sim":276.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":276.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":234.0, @@ -481213,11 +483206,11 @@ }, { "sim":178.0, - "partner":"4uad" + "partner":"7rht" }, { "sim":178.0, - "partner":"7rht" + "partner":"4uad" }, { "sim":177.0, @@ -481237,15 +483230,15 @@ }, { "sim":174.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":174.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":174.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":174.0, @@ -481269,11 +483262,11 @@ }, { "sim":172.0, - "partner":"4pvz" + "partner":"1bk5" }, { "sim":172.0, - "partner":"1bk5" + "partner":"4pvz" }, { "sim":172.0, @@ -481317,11 +483310,11 @@ }, { "sim":168.0, - "partner":"4u5o" + "partner":"3ve6" }, { "sim":168.0, - "partner":"3ve6" + "partner":"6mjl" }, { "sim":168.0, @@ -481331,10 +483324,6 @@ "sim":168.0, "partner":"4u5s" }, - { - "sim":168.0, - "partner":"6mjl" - }, { "sim":168.0, "partner":"4u5u" @@ -481353,7 +483342,7 @@ }, { "sim":168.0, - "partner":"3l3q" + "partner":"4u5o" }, { "sim":168.0, @@ -481361,11 +483350,11 @@ }, { "sim":168.0, - "partner":"5hhg" + "partner":"3l3q" }, { "sim":168.0, - "partner":"3btr" + "partner":"5hhg" }, { "sim":168.0, @@ -481373,7 +483362,7 @@ }, { "sim":168.0, - "partner":"1y2a" + "partner":"3btr" }, { "sim":168.0, @@ -481395,6 +483384,10 @@ "sim":168.0, "partner":"7leu" }, + { + "sim":168.0, + "partner":"1y2a" + }, { "sim":168.0, "partner":"6iw8" @@ -481427,10 +483420,6 @@ "sim":168.0, "partner":"1ial" }, - { - "sim":168.0, - "partner":"3zir" - }, { "sim":168.0, "partner":"2ynr" @@ -481451,6 +483440,10 @@ "sim":168.0, "partner":"3ziq" }, + { + "sim":168.0, + "partner":"3zir" + }, { "sim":168.0, "partner":"6wx9" @@ -481465,35 +483458,35 @@ }, { "sim":167.0, - "partner":"6bwa" + "partner":"7rfy" }, { "sim":167.0, - "partner":"6bvz" + "partner":"6wx8" }, { "sim":167.0, - "partner":"6bwb" + "partner":"7rg5" }, { "sim":167.0, - "partner":"7rfy" + "partner":"6bvv" }, { "sim":167.0, - "partner":"7rg5" + "partner":"6bw9" }, { "sim":167.0, - "partner":"6wx8" + "partner":"6bwa" }, { "sim":167.0, - "partner":"6bvv" + "partner":"6bvz" }, { "sim":167.0, - "partner":"6bw9" + "partner":"6bwb" }, { "sim":167.0, @@ -481505,11 +483498,11 @@ }, { "sim":167.0, - "partner":"7lf4" + "partner":"7lfc" }, { "sim":167.0, - "partner":"7lfc" + "partner":"7lf4" }, { "sim":166.0, @@ -481517,19 +483510,19 @@ }, { "sim":166.0, - "partner":"3q5u" + "partner":"5wun" }, { "sim":166.0, - "partner":"5wum" + "partner":"6p6a" }, { "sim":166.0, - "partner":"6wba" + "partner":"6wbb" }, { "sim":166.0, - "partner":"5wun" + "partner":"7m60" }, { "sim":166.0, @@ -481537,59 +483530,59 @@ }, { "sim":166.0, - "partner":"6p6a" + "partner":"6wbc" }, { "sim":166.0, - "partner":"6wbb" + "partner":"5x8n" }, { "sim":166.0, - "partner":"7m60" + "partner":"6p6e" }, { "sim":166.0, - "partner":"5x8n" + "partner":"4yi0" }, { "sim":166.0, - "partner":"6wbc" + "partner":"3knd" }, { "sim":166.0, - "partner":"6p6e" + "partner":"1ejl" }, { "sim":166.0, - "partner":"1ejl" + "partner":"1ejy" }, { "sim":166.0, - "partner":"4yi0" + "partner":"5b56" }, { "sim":166.0, - "partner":"3knd" + "partner":"1pjm" }, { "sim":166.0, - "partner":"1ejy" + "partner":"1iq1" }, { "sim":166.0, - "partner":"5b56" + "partner":"1pjn" }, { "sim":166.0, - "partner":"1iq1" + "partner":"3q5u" }, { "sim":166.0, - "partner":"1pjm" + "partner":"5wum" }, { "sim":166.0, - "partner":"1pjn" + "partner":"6wba" }, { "sim":166.0, @@ -481619,10 +483612,6 @@ "sim":166.0, "partner":"4ba3" }, - { - "sim":166.0, - "partner":"4htv" - }, { "sim":166.0, "partner":"5umz" @@ -481637,155 +483626,159 @@ }, { "sim":166.0, - "partner":"3rzx" + "partner":"4htv" }, { "sim":166.0, - "partner":"5e6q" + "partner":"5fc8" }, { "sim":166.0, - "partner":"3oqs" + "partner":"6bw1" }, { "sim":166.0, - "partner":"5w4f" + "partner":"5w4g" }, { "sim":166.0, - "partner":"6d7m" + "partner":"7rfz" }, { "sim":166.0, - "partner":"7rfx" + "partner":"7l04" }, { "sim":166.0, - "partner":"5fc8" + "partner":"3ukw" }, { "sim":166.0, - "partner":"6bw0" + "partner":"7rg0" }, { "sim":166.0, - "partner":"5w4g" + "partner":"3ukx" }, { "sim":166.0, - "partner":"6bw1" + "partner":"7rg1" }, { "sim":166.0, - "partner":"7rfz" + "partner":"7jvo" }, { "sim":166.0, - "partner":"3ukw" + "partner":"3uky" }, { "sim":166.0, - "partner":"7l04" + "partner":"5ekf" }, { "sim":166.0, - "partner":"7rg0" + "partner":"7rg2" }, { "sim":166.0, - "partner":"3ukx" + "partner":"3ukz" }, { "sim":166.0, - "partner":"7rg1" + "partner":"5u5p" }, { "sim":166.0, - "partner":"3uky" + "partner":"7rg3" }, { "sim":166.0, - "partner":"5ekf" + "partner":"5ekg" }, { "sim":166.0, - "partner":"7jvo" + "partner":"5svz" }, { "sim":166.0, - "partner":"7rg2" + "partner":"3ul0" }, { "sim":166.0, - "partner":"3ukz" + "partner":"6wx7" }, { "sim":166.0, - "partner":"5u5p" + "partner":"7rg4" }, { "sim":166.0, - "partner":"5ekg" + "partner":"3ul1" }, { "sim":166.0, - "partner":"5svz" + "partner":"3rz9" }, { "sim":166.0, - "partner":"7rg3" + "partner":"7rg6" }, { "sim":166.0, - "partner":"3ul0" + "partner":"5klr" }, { "sim":166.0, - "partner":"3ul1" + "partner":"6bvt" }, { "sim":166.0, - "partner":"7rg4" + "partner":"3uvu" }, { "sim":166.0, - "partner":"3rz9" + "partner":"5u5r" }, { "sim":166.0, - "partner":"6wx7" + "partner":"5w41" }, { "sim":166.0, - "partner":"7rg6" + "partner":"5klt" }, { "sim":166.0, - "partner":"5klr" + "partner":"5w4e" }, { "sim":166.0, - "partner":"3uvu" + "partner":"3rzx" }, { "sim":166.0, - "partner":"5u5r" + "partner":"5e6q" }, { "sim":166.0, - "partner":"6bvt" + "partner":"6d7m" }, { "sim":166.0, - "partner":"5w41" + "partner":"3oqs" }, { "sim":166.0, - "partner":"5klt" + "partner":"5w4f" }, { "sim":166.0, - "partner":"5w4e" + "partner":"6bw0" + }, + { + "sim":166.0, + "partner":"7rfx" }, { "sim":166.0, @@ -481936,72 +483929,72 @@ ], "subtitle":"L8-complex forming rubisco derived from ancestral sequence reconstruction of the last common ancestor of form i'' and form i rubiscos", "tags":[ - "ribulose 1", - "5-bisphosphate carboxylase\/oxydase", "rubisco", - "lyase" + "lyase", + "5-bisphosphate carboxylase\/oxydase", + "ribulose 1" ], "keywords":[ - "work", - "evolution", - "oxygen", - "remained", - "adapting", - "recapitulate", "rising", - "specificity", + "determinants", "carbon", - "use", - "ambient", + "specificity", + "structural", + "show", + "work", + "provides", + "recapitulate", "discriminate", - "biochemical", - "undesired", - "template", "photosynthetic", - "increased", - "strongly", - "emergence", + "carboxylation", "substrate", - "gain", - "illuminates", - "rubiscos", + "reconstruction", "approaches", - "became", + "side", + "environment", "subunit", - "ancestral", - "rubisco", - "oxygenated", - "determinants", - "carboxylation", - "provides", + "sheds", + "important", + "atmospheric", "retrace", - "light", - "show", - "elusive", - "reconstruction", - "essentiality", - "efficiency", + "dioxygen", "investigating", - "atmospheric", + "template", "interactions", - "using", - "levels", - "present", - "sheds", - "essential", - "function", - "sequence", + "ambient", + "undesired", + "strongly", + "increased", "adaptation", - "environment", + "event", + "biochemical", + "function", + "became", + "light", "dioxide", + "essentiality", + "remained", + "use", + "ancestral", + "gain", + "essential", + "rubiscos", + "sequence", + "oxygen", + "levels", + "oxygenated", + "emergence", + "evolution", + "rubisco", + "efficiency", + "present", + "adapting", + "elusive", "organisms", - "accessory", "gained", - "side", - "structural", - "event", - "important", - "dioxygen" + "accessory", + "using", + "illuminates" ], "release_date":"2022-10-12", "publication":"\"Evolution of increased complexity and specificity at the dawn of form I Rubiscos\", Science, 378, 155-160", @@ -482034,23 +484027,23 @@ "seq_thr_sim_designed":[ { "sim":930.0, - "partner":"7qsy" + "partner":"7qsx" }, { "sim":930.0, - "partner":"7qsx" + "partner":"7qsy" }, { "sim":929.0, - "partner":"7qt1" + "partner":"7qsz" }, { "sim":929.0, - "partner":"7qsz" + "partner":"7qvi" }, { "sim":929.0, - "partner":"7qvi" + "partner":"7qt1" }, { "sim":923.0, @@ -482088,7 +484081,7 @@ }, { "sim":651.0, - "partner":"2wvw" + "partner":"6hbc" }, { "sim":651.0, @@ -482096,7 +484089,7 @@ }, { "sim":651.0, - "partner":"6hbc" + "partner":"2wvw" }, { "sim":651.0, @@ -482106,10 +484099,6 @@ "sim":651.0, "partner":"6lrs" }, - { - "sim":651.0, - "partner":"6z1f" - }, { "sim":651.0, "partner":"6z1g" @@ -482122,6 +484111,10 @@ "sim":651.0, "partner":"7xsd" }, + { + "sim":651.0, + "partner":"6z1f" + }, { "sim":651.0, "partner":"6kkm" @@ -482196,16 +484189,12 @@ }, { "sim":626.0, - "partner":"7jn4" + "partner":"2v69" }, { "sim":626.0, "partner":"7jsx" }, - { - "sim":626.0, - "partner":"2v69" - }, { "sim":626.0, "partner":"1ir2" @@ -482216,11 +484205,11 @@ }, { "sim":626.0, - "partner":"1gk8" + "partner":"7jfo" }, { "sim":626.0, - "partner":"7jfo" + "partner":"1gk8" }, { "sim":626.0, @@ -482230,21 +484219,25 @@ "sim":626.0, "partner":"1uzd" }, + { + "sim":626.0, + "partner":"7jn4" + }, { "sim":625.0, "partner":"1upm" }, { "sim":625.0, - "partner":"1uwa" + "partner":"8ruc" }, { "sim":625.0, - "partner":"1upp" + "partner":"1uwa" }, { "sim":625.0, - "partner":"8ruc" + "partner":"1upp" }, { "sim":625.0, @@ -482324,15 +484317,15 @@ }, { "sim":530.0, - "partner":"4f0k" + "partner":"4f0m" }, { "sim":530.0, - "partner":"4f0m" + "partner":"4f0h" }, { "sim":530.0, - "partner":"4f0h" + "partner":"4f0k" }, { "sim":505.0, @@ -482372,11 +484365,11 @@ }, { "sim":320.0, - "partner":"3kdn" + "partner":"3a13" }, { "sim":320.0, - "partner":"3a13" + "partner":"3kdn" }, { "sim":319.0, @@ -482448,11 +484441,11 @@ }, { "sim":186.0, - "partner":"7vwx" + "partner":"9rub" }, { "sim":186.0, - "partner":"9rub" + "partner":"7vwx" }, { "sim":186.0, @@ -482484,11 +484477,11 @@ }, { "sim":152.0, - "partner":"1ykw" + "partner":"1tel" }, { "sim":152.0, - "partner":"1tel" + "partner":"1ykw" }, { "sim":150.0, @@ -482504,15 +484497,15 @@ }, { "sim":142.0, - "partner":"2oel" + "partner":"2oek" }, { "sim":142.0, - "partner":"2oem" + "partner":"2oel" }, { "sim":142.0, - "partner":"2oek" + "partner":"2oem" }, { "sim":137.0, @@ -482536,10 +484529,6 @@ "sim":0.9926999807, "partner":"7qsy" }, - { - "sim":0.9947000146, - "partner":"7qsx" - }, { "sim":0.9944999814, "partner":"7qsz" @@ -482548,6 +484537,10 @@ "sim":0.9916999936, "partner":"8qmv" }, + { + "sim":0.9947000146, + "partner":"7qsx" + }, { "sim":0.9921000004, "partner":"7qt1" @@ -482577,7 +484570,7 @@ ], "seq_max_sim_designed":{ "sim":930.0, - "partner":"7qsy" + "partner":"7qsx" }, "seq_max_sim_natural":{ "sim":667.0, @@ -482667,72 +484660,72 @@ ], "subtitle":"L8s8-complex forming rubisco derived from ancestral sequence reconstruction of the last common ancestor of ssu-bearing form i rubiscos", "tags":[ - "ribulose 1", - "5-bisphosphate carboxylase\/oxydase", "rubisco", - "lyase" + "lyase", + "5-bisphosphate carboxylase\/oxydase", + "ribulose 1" ], "keywords":[ - "work", - "evolution", - "oxygen", - "remained", - "adapting", - "recapitulate", "rising", - "specificity", + "determinants", "carbon", - "use", - "ambient", + "specificity", + "structural", + "show", + "work", + "provides", + "recapitulate", "discriminate", - "biochemical", - "undesired", - "template", "photosynthetic", - "increased", - "strongly", - "emergence", + "carboxylation", "substrate", - "gain", - "illuminates", - "rubiscos", + "reconstruction", "approaches", - "became", + "side", + "environment", "subunit", - "ancestral", - "rubisco", - "oxygenated", - "determinants", - "carboxylation", - "provides", + "sheds", + "important", + "atmospheric", "retrace", - "light", - "show", - "elusive", - "reconstruction", - "essentiality", - "efficiency", + "dioxygen", "investigating", - "atmospheric", + "template", "interactions", - "using", - "levels", - "present", - "sheds", - "essential", - "function", - "sequence", + "ambient", + "undesired", + "strongly", + "increased", "adaptation", - "environment", + "event", + "biochemical", + "function", + "became", + "light", "dioxide", + "essentiality", + "remained", + "use", + "ancestral", + "gain", + "essential", + "rubiscos", + "sequence", + "oxygen", + "levels", + "oxygenated", + "emergence", + "evolution", + "rubisco", + "efficiency", + "present", + "adapting", + "elusive", "organisms", - "accessory", "gained", - "side", - "structural", - "event", - "important", - "dioxygen" + "accessory", + "using", + "illuminates" ], "release_date":"2022-10-12", "publication":"\"Evolution of increased complexity and specificity at the dawn of form I Rubiscos\", Science, 378, 155-160", @@ -482763,21 +484756,13 @@ "previous_design":"7qsv", "next_design":"7qsx", "seq_thr_sim_designed":[ - { - "sim":774.0, - "partner":"7qt1" - }, { "sim":784.0, - "partner":"8qmw" - }, - { - "sim":772.0, - "partner":"7qsy" + "partner":"8qmv" }, { "sim":784.0, - "partner":"8qmv" + "partner":"8qmw" }, { "sim":779.0, @@ -482787,10 +484772,18 @@ "sim":774.0, "partner":"7qsz" }, + { + "sim":774.0, + "partner":"7qt1" + }, { "sim":772.0, "partner":"7qsx" }, + { + "sim":772.0, + "partner":"7qsy" + }, { "sim":754.0, "partner":"7qsv" @@ -482857,10 +484850,6 @@ "sim":786.0, "partner":"1uzd" }, - { - "sim":791.0, - "partner":"7zbt" - }, { "sim":792.0, "partner":"6uew" @@ -482870,17 +484859,21 @@ "partner":"1svd" }, { - "sim":782.0, - "partner":"6kyj" + "sim":791.0, + "partner":"7zbt" }, { - "sim":780.0, - "partner":"1ej7" + "sim":782.0, + "partner":"6kyj" }, { "sim":781.0, "partner":"1rlc" }, + { + "sim":780.0, + "partner":"1ej7" + }, { "sim":756.0, "partner":"1rld" @@ -482901,14 +484894,6 @@ "sim":785.0, "partner":"1uw9" }, - { - "sim":782.0, - "partner":"2v68" - }, - { - "sim":781.0, - "partner":"2v6a" - }, { "sim":781.0, "partner":"2vdh" @@ -482929,13 +484914,21 @@ "sim":784.0, "partner":"1uwa" }, + { + "sim":782.0, + "partner":"2vdi" + }, { "sim":786.0, "partner":"1gk8" }, { "sim":782.0, - "partner":"2vdi" + "partner":"2v68" + }, + { + "sim":781.0, + "partner":"2v6a" }, { "sim":788.0, @@ -482945,10 +484938,6 @@ "sim":777.0, "partner":"1aa1" }, - { - "sim":777.0, - "partner":"1rco" - }, { "sim":777.0, "partner":"1rcx" @@ -482959,11 +484948,11 @@ }, { "sim":777.0, - "partner":"1aus" + "partner":"1upm" }, { "sim":777.0, - "partner":"1upm" + "partner":"1aus" }, { "sim":777.0, @@ -482973,6 +484962,10 @@ "sim":777.0, "partner":"1rbo" }, + { + "sim":777.0, + "partner":"1rco" + }, { "sim":777.0, "partner":"1upp" @@ -482983,15 +484976,15 @@ }, { "sim":786.0, - "partner":"7jfo" + "partner":"7jn4" }, { "sim":786.0, - "partner":"7jn4" + "partner":"7jsx" }, { "sim":786.0, - "partner":"7jsx" + "partner":"7jfo" }, { "sim":781.0, @@ -483091,11 +485084,11 @@ }, { "sim":316.0, - "partner":"3kdn" + "partner":"3a13" }, { "sim":316.0, - "partner":"3a13" + "partner":"3kdn" }, { "sim":315.0, @@ -483167,11 +485160,11 @@ }, { "sim":169.0, - "partner":"7vwx" + "partner":"9rub" }, { "sim":169.0, - "partner":"9rub" + "partner":"7vwx" }, { "sim":169.0, @@ -483219,11 +485212,11 @@ }, { "sim":125.0, - "partner":"1ykw" + "partner":"1tel" }, { "sim":125.0, - "partner":"1tel" + "partner":"1ykw" }, { "sim":124.0, @@ -483235,19 +485228,19 @@ }, { "sim":115.0, - "partner":"2oel" + "partner":"2oej" }, { "sim":115.0, - "partner":"2oem" + "partner":"2oek" }, { "sim":115.0, - "partner":"2oej" + "partner":"2oel" }, { "sim":115.0, - "partner":"2oek" + "partner":"2oem" }, { "sim":114.0, @@ -483271,13 +485264,13 @@ "sim":0.992299974, "partner":"7qt1" }, - { - "sim":0.9732000232, - "partner":"7qsy" - }, { "sim":0.9553999901, "partner":"8qmv" + }, + { + "sim":0.9732000232, + "partner":"7qsy" } ], "struct_thr_sim_natural":[ @@ -483297,14 +485290,14 @@ "sim":0.9787999988, "partner":"1wdd" }, - { - "sim":0.9733999968, - "partner":"2v67" - }, { "sim":0.9743000269, "partner":"2vdh" }, + { + "sim":0.9733999968, + "partner":"2v67" + }, { "sim":0.9728000164, "partner":"1gk8" @@ -483313,6 +485306,10 @@ "sim":0.9738000035, "partner":"2v63" }, + { + "sim":0.9736999869, + "partner":"2v68" + }, { "sim":0.9771999717, "partner":"1rbo" @@ -483321,25 +485318,21 @@ "sim":0.9743999839, "partner":"1uwa" }, - { - "sim":0.9736999869, - "partner":"2v68" - }, { "sim":0.9757999778, "partner":"2vdi" }, { - "sim":0.9775999784, - "partner":"1upm" + "sim":0.9764999747, + "partner":"1uw9" }, { "sim":0.9634000063, "partner":"2v6a" }, { - "sim":0.9764999747, - "partner":"1uw9" + "sim":0.9775999784, + "partner":"1upm" }, { "sim":0.961499989, @@ -483434,72 +485427,72 @@ ], "subtitle":"Non-obligately l8s8-complex forming rubisco derived from ancestral sequence reconstruction and rational engineering in l8 complex", "tags":[ - "ribulose 1", - "5-bisphosphate carboxylase\/oxydase", "rubisco", - "lyase" + "lyase", + "5-bisphosphate carboxylase\/oxydase", + "ribulose 1" ], "keywords":[ - "work", - "evolution", - "oxygen", - "remained", - "adapting", - "recapitulate", "rising", - "specificity", + "determinants", "carbon", - "use", - "ambient", + "specificity", + "structural", + "show", + "work", + "provides", + "recapitulate", "discriminate", - "biochemical", - "undesired", - "template", "photosynthetic", - "increased", - "strongly", - "emergence", + "carboxylation", "substrate", - "gain", - "illuminates", - "rubiscos", + "reconstruction", "approaches", - "became", + "side", + "environment", "subunit", - "ancestral", - "rubisco", - "oxygenated", - "determinants", - "carboxylation", - "provides", + "sheds", + "important", + "atmospheric", "retrace", - "light", - "show", - "elusive", - "reconstruction", - "essentiality", - "efficiency", + "dioxygen", "investigating", - "atmospheric", + "template", "interactions", - "using", - "levels", - "present", - "sheds", - "essential", - "function", - "sequence", + "ambient", + "undesired", + "strongly", + "increased", "adaptation", - "environment", + "event", + "biochemical", + "function", + "became", + "light", "dioxide", + "essentiality", + "remained", + "use", + "ancestral", + "gain", + "essential", + "rubiscos", + "sequence", + "oxygen", + "levels", + "oxygenated", + "emergence", + "evolution", + "rubisco", + "efficiency", + "present", + "adapting", + "elusive", "organisms", - "accessory", "gained", - "side", - "structural", - "event", - "important", - "dioxygen" + "accessory", + "using", + "illuminates" ], "release_date":"2022-10-12", "publication":"\"Evolution of increased complexity and specificity at the dawn of form I Rubiscos\", Science, 378, 155-160", @@ -483540,11 +485533,11 @@ }, { "sim":943.0, - "partner":"7qt1" + "partner":"7qsz" }, { "sim":943.0, - "partner":"7qsz" + "partner":"7qt1" }, { "sim":938.0, @@ -483578,7 +485571,7 @@ }, { "sim":666.0, - "partner":"2wvw" + "partner":"6hbc" }, { "sim":666.0, @@ -483586,7 +485579,7 @@ }, { "sim":666.0, - "partner":"6hbc" + "partner":"2wvw" }, { "sim":666.0, @@ -483596,10 +485589,6 @@ "sim":666.0, "partner":"6lrs" }, - { - "sim":666.0, - "partner":"6z1f" - }, { "sim":666.0, "partner":"6z1g" @@ -483612,6 +485601,10 @@ "sim":666.0, "partner":"7xsd" }, + { + "sim":666.0, + "partner":"6z1f" + }, { "sim":666.0, "partner":"6kkm" @@ -483690,11 +485683,11 @@ }, { "sim":636.0, - "partner":"2vdh" + "partner":"1upm" }, { "sim":636.0, - "partner":"7jn4" + "partner":"2v69" }, { "sim":636.0, @@ -483702,11 +485695,7 @@ }, { "sim":636.0, - "partner":"1upm" - }, - { - "sim":636.0, - "partner":"2v69" + "partner":"8ruc" }, { "sim":636.0, @@ -483718,11 +485707,11 @@ }, { "sim":636.0, - "partner":"1gk8" + "partner":"7jfo" }, { "sim":636.0, - "partner":"7jfo" + "partner":"1gk8" }, { "sim":636.0, @@ -483738,7 +485727,11 @@ }, { "sim":636.0, - "partner":"8ruc" + "partner":"7jn4" + }, + { + "sim":636.0, + "partner":"2vdh" }, { "sim":636.0, @@ -483746,11 +485739,11 @@ }, { "sim":635.0, - "partner":"1aus" + "partner":"1uwa" }, { "sim":635.0, - "partner":"1uwa" + "partner":"1aus" }, { "sim":635.0, @@ -483822,15 +485815,15 @@ }, { "sim":539.0, - "partner":"4f0k" + "partner":"4f0m" }, { "sim":539.0, - "partner":"4f0m" + "partner":"4f0h" }, { "sim":539.0, - "partner":"4f0h" + "partner":"4f0k" }, { "sim":515.0, @@ -483870,11 +485863,11 @@ }, { "sim":318.0, - "partner":"3kdn" + "partner":"3a13" }, { "sim":318.0, - "partner":"3a13" + "partner":"3kdn" }, { "sim":317.0, @@ -483910,15 +485903,15 @@ }, { "sim":190.0, - "partner":"5hjx" + "partner":"4lf1" }, { "sim":190.0, - "partner":"4lf1" + "partner":"4lf2" }, { "sim":190.0, - "partner":"4lf2" + "partner":"5hjx" }, { "sim":190.0, @@ -483946,11 +485939,11 @@ }, { "sim":183.0, - "partner":"7vwx" + "partner":"9rub" }, { "sim":183.0, - "partner":"9rub" + "partner":"7vwx" }, { "sim":183.0, @@ -484006,15 +485999,15 @@ }, { "sim":135.0, - "partner":"2oel" + "partner":"2oek" }, { "sim":135.0, - "partner":"2oem" + "partner":"2oel" }, { "sim":135.0, - "partner":"2oek" + "partner":"2oem" }, { "sim":122.0, @@ -484030,14 +486023,14 @@ } ], "struct_thr_sim_designed":[ - { - "sim":0.9994000196, - "partner":"7qsy" - }, { "sim":0.9998999834, "partner":"7qsz" }, + { + "sim":0.9994000196, + "partner":"7qsy" + }, { "sim":0.9980000257, "partner":"7qt1" @@ -484068,6 +486061,10 @@ "sim":0.9552999735, "partner":"1rbl" }, + { + "sim":0.9509000182, + "partner":"3zxw" + }, { "sim":0.9589999914, "partner":"6ura" @@ -484080,10 +486077,6 @@ "sim":0.9527000189, "partner":"1rbo" }, - { - "sim":0.9509000182, - "partner":"3zxw" - }, { "sim":0.950699985, "partner":"1upm" @@ -484181,72 +486174,72 @@ ], "subtitle":"Non-obligately l8s8-complex forming rubisco derived from ancestral sequence reconstruction and rational engineering in l8s8 complex", "tags":[ - "ribulose 1", - "5-bisphosphate carboxylase\/oxydase", "rubisco", - "lyase" + "lyase", + "5-bisphosphate carboxylase\/oxydase", + "ribulose 1" ], "keywords":[ - "work", - "evolution", - "oxygen", - "remained", - "adapting", - "recapitulate", "rising", - "specificity", + "determinants", "carbon", - "use", - "ambient", + "specificity", + "structural", + "show", + "work", + "provides", + "recapitulate", "discriminate", - "biochemical", - "undesired", - "template", "photosynthetic", - "increased", - "strongly", - "emergence", + "carboxylation", "substrate", - "gain", - "illuminates", - "rubiscos", + "reconstruction", "approaches", - "became", + "side", + "environment", "subunit", - "ancestral", - "rubisco", - "oxygenated", - "determinants", - "carboxylation", - "provides", + "sheds", + "important", + "atmospheric", "retrace", - "light", - "show", - "elusive", - "reconstruction", - "essentiality", - "efficiency", + "dioxygen", "investigating", - "atmospheric", + "template", "interactions", - "using", - "levels", - "present", - "sheds", - "essential", - "function", - "sequence", + "ambient", + "undesired", + "strongly", + "increased", "adaptation", - "environment", + "event", + "biochemical", + "function", + "became", + "light", "dioxide", + "essentiality", + "remained", + "use", + "ancestral", + "gain", + "essential", + "rubiscos", + "sequence", + "oxygen", + "levels", + "oxygenated", + "emergence", + "evolution", + "rubisco", + "efficiency", + "present", + "adapting", + "elusive", "organisms", - "accessory", "gained", - "side", - "structural", - "event", - "important", - "dioxygen" + "accessory", + "using", + "illuminates" ], "release_date":"2022-10-12", "publication":"\"Evolution of increased complexity and specificity at the dawn of form I Rubiscos\", Science, 378, 155-160", @@ -484277,18 +486270,6 @@ "previous_design":"7qsx", "next_design":"7qsz", "seq_thr_sim_designed":[ - { - "sim":943.0, - "partner":"7qt1" - }, - { - "sim":771.0, - "partner":"7qsw" - }, - { - "sim":938.0, - "partner":"8qmw" - }, { "sim":945.0, "partner":"7qsx" @@ -484301,13 +486282,25 @@ "sim":943.0, "partner":"7qsz" }, + { + "sim":943.0, + "partner":"7qt1" + }, { "sim":938.0, "partner":"8qmv" }, + { + "sim":938.0, + "partner":"8qmw" + }, { "sim":927.0, "partner":"7qsv" + }, + { + "sim":771.0, + "partner":"7qsw" } ], "seq_thr_sim_natural":[ @@ -484325,7 +486318,7 @@ }, { "sim":666.0, - "partner":"2wvw" + "partner":"6hbc" }, { "sim":666.0, @@ -484333,7 +486326,7 @@ }, { "sim":666.0, - "partner":"6hbc" + "partner":"2wvw" }, { "sim":666.0, @@ -484343,10 +486336,6 @@ "sim":666.0, "partner":"6lrs" }, - { - "sim":666.0, - "partner":"6z1f" - }, { "sim":666.0, "partner":"6z1g" @@ -484359,6 +486348,10 @@ "sim":666.0, "partner":"7xsd" }, + { + "sim":666.0, + "partner":"6z1f" + }, { "sim":666.0, "partner":"6kkm" @@ -484437,11 +486430,11 @@ }, { "sim":636.0, - "partner":"2vdh" + "partner":"1upm" }, { "sim":636.0, - "partner":"7jn4" + "partner":"2v69" }, { "sim":636.0, @@ -484449,11 +486442,7 @@ }, { "sim":636.0, - "partner":"1upm" - }, - { - "sim":636.0, - "partner":"2v69" + "partner":"8ruc" }, { "sim":636.0, @@ -484465,11 +486454,11 @@ }, { "sim":636.0, - "partner":"1gk8" + "partner":"7jfo" }, { "sim":636.0, - "partner":"7jfo" + "partner":"1gk8" }, { "sim":636.0, @@ -484485,7 +486474,11 @@ }, { "sim":636.0, - "partner":"8ruc" + "partner":"7jn4" + }, + { + "sim":636.0, + "partner":"2vdh" }, { "sim":636.0, @@ -484493,11 +486486,11 @@ }, { "sim":635.0, - "partner":"1aus" + "partner":"1uwa" }, { "sim":635.0, - "partner":"1uwa" + "partner":"1aus" }, { "sim":635.0, @@ -484569,15 +486562,15 @@ }, { "sim":539.0, - "partner":"4f0k" + "partner":"4f0m" }, { "sim":539.0, - "partner":"4f0m" + "partner":"4f0h" }, { "sim":539.0, - "partner":"4f0h" + "partner":"4f0k" }, { "sim":515.0, @@ -484617,11 +486610,11 @@ }, { "sim":318.0, - "partner":"3kdn" + "partner":"3a13" }, { "sim":318.0, - "partner":"3a13" + "partner":"3kdn" }, { "sim":317.0, @@ -484657,15 +486650,15 @@ }, { "sim":190.0, - "partner":"5hjx" + "partner":"4lf1" }, { "sim":190.0, - "partner":"4lf1" + "partner":"4lf2" }, { "sim":190.0, - "partner":"4lf2" + "partner":"5hjx" }, { "sim":190.0, @@ -484693,11 +486686,11 @@ }, { "sim":183.0, - "partner":"7vwx" + "partner":"9rub" }, { "sim":183.0, - "partner":"9rub" + "partner":"7vwx" }, { "sim":183.0, @@ -484753,15 +486746,15 @@ }, { "sim":135.0, - "partner":"2oel" + "partner":"2oek" }, { "sim":135.0, - "partner":"2oem" + "partner":"2oel" }, { "sim":135.0, - "partner":"2oek" + "partner":"2oem" }, { "sim":122.0, @@ -484797,55 +486790,59 @@ "sim":0.9991999865, "partner":"7qsx" }, - { - "sim":0.9929999709, - "partner":"8qmv" - }, { "sim":0.9951000214, "partner":"7qsv" }, + { + "sim":0.9929999709, + "partner":"8qmv" + }, { "sim":0.9801999927, "partner":"7qvi" } ], "struct_thr_sim_natural":[ - { - "sim":0.9571999907, - "partner":"1rbl" - }, - { - "sim":0.9524999857, - "partner":"3zxw" - }, { "sim":0.9542999864, "partner":"1wdd" }, { - "sim":0.9570999742, - "partner":"6ura" + "sim":0.9569000006, + "partner":"1rbo" }, { - "sim":0.9563000202, - "partner":"5iu0" + "sim":0.9520999789, + "partner":"1uwa" }, { "sim":0.9534999728, "partner":"2v67" }, { - "sim":0.9569000006, - "partner":"1rbo" + "sim":0.9564999938, + "partner":"2v68" }, { - "sim":0.9520999789, - "partner":"1uwa" + "sim":0.9552999735, + "partner":"1uw9" }, { - "sim":0.9564999938, - "partner":"2v68" + "sim":0.9571999907, + "partner":"1rbl" + }, + { + "sim":0.9524999857, + "partner":"3zxw" + }, + { + "sim":0.9570999742, + "partner":"6ura" + }, + { + "sim":0.9563000202, + "partner":"5iu0" }, { "sim":0.9534000158, @@ -484854,10 +486851,6 @@ { "sim":0.9526000023, "partner":"1upm" - }, - { - "sim":0.9552999735, - "partner":"1uw9" } ], "seq_max_sim_designed":{ @@ -484944,72 +486937,72 @@ ], "subtitle":"Non-obligately l8s8-complex forming rubisco derived from ancestral sequence reconstruction and rational engineering in l8 complex with substitution e170n", "tags":[ - "ribulose 1", - "5-bisphosphate carboxylase\/oxydase", "rubisco", - "lyase" + "lyase", + "5-bisphosphate carboxylase\/oxydase", + "ribulose 1" ], "keywords":[ - "work", - "evolution", - "oxygen", - "remained", - "adapting", - "recapitulate", "rising", - "specificity", + "determinants", "carbon", - "use", - "ambient", + "specificity", + "structural", + "show", + "work", + "provides", + "recapitulate", "discriminate", - "biochemical", - "undesired", - "template", "photosynthetic", - "increased", - "strongly", - "emergence", + "carboxylation", "substrate", - "gain", - "illuminates", - "rubiscos", + "reconstruction", "approaches", - "became", + "side", + "environment", "subunit", - "ancestral", - "rubisco", - "oxygenated", - "determinants", - "carboxylation", - "provides", + "sheds", + "important", + "atmospheric", "retrace", - "light", - "show", - "elusive", - "reconstruction", - "essentiality", - "efficiency", + "dioxygen", "investigating", - "atmospheric", + "template", "interactions", - "using", - "levels", - "present", - "sheds", - "essential", - "function", - "sequence", + "ambient", + "undesired", + "strongly", + "increased", "adaptation", - "environment", + "event", + "biochemical", + "function", + "became", + "light", "dioxide", + "essentiality", + "remained", + "use", + "ancestral", + "gain", + "essential", + "rubiscos", + "sequence", + "oxygen", + "levels", + "oxygenated", + "emergence", + "evolution", + "rubisco", + "efficiency", + "present", + "adapting", + "elusive", "organisms", - "accessory", "gained", - "side", - "structural", - "event", - "important", - "dioxygen" + "accessory", + "using", + "illuminates" ], "release_date":"2022-10-12", "publication":"\"Evolution of increased complexity and specificity at the dawn of form I Rubiscos\", Science, 378, 155-160", @@ -485046,11 +487039,11 @@ }, { "sim":943.0, - "partner":"7qsy" + "partner":"7qsx" }, { "sim":943.0, - "partner":"7qsx" + "partner":"7qsy" }, { "sim":942.0, @@ -485092,7 +487085,7 @@ }, { "sim":668.0, - "partner":"2wvw" + "partner":"6hbc" }, { "sim":668.0, @@ -485100,7 +487093,7 @@ }, { "sim":668.0, - "partner":"6hbc" + "partner":"2wvw" }, { "sim":668.0, @@ -485110,10 +487103,6 @@ "sim":668.0, "partner":"6lrs" }, - { - "sim":668.0, - "partner":"6z1f" - }, { "sim":668.0, "partner":"6z1g" @@ -485126,6 +487115,10 @@ "sim":668.0, "partner":"7xsd" }, + { + "sim":668.0, + "partner":"6z1f" + }, { "sim":668.0, "partner":"6kkm" @@ -485200,11 +487193,11 @@ }, { "sim":639.0, - "partner":"2vdh" + "partner":"1upm" }, { "sim":639.0, - "partner":"1upm" + "partner":"8ruc" }, { "sim":639.0, @@ -485212,7 +487205,7 @@ }, { "sim":639.0, - "partner":"8ruc" + "partner":"2vdh" }, { "sim":639.0, @@ -485220,7 +487213,7 @@ }, { "sim":638.0, - "partner":"7jn4" + "partner":"2v69" }, { "sim":638.0, @@ -485228,7 +487221,7 @@ }, { "sim":638.0, - "partner":"2v69" + "partner":"1uwa" }, { "sim":638.0, @@ -485238,29 +487231,25 @@ "sim":638.0, "partner":"1ir2" }, - { - "sim":638.0, - "partner":"1uwa" - }, { "sim":638.0, "partner":"1uzh" }, { "sim":638.0, - "partner":"1gk8" + "partner":"1rxo" }, { "sim":638.0, - "partner":"1rxo" + "partner":"7jfo" }, { "sim":638.0, - "partner":"1rco" + "partner":"1gk8" }, { "sim":638.0, - "partner":"7jfo" + "partner":"1rco" }, { "sim":638.0, @@ -485278,6 +487267,10 @@ "sim":638.0, "partner":"1uzd" }, + { + "sim":638.0, + "partner":"7jn4" + }, { "sim":638.0, "partner":"1aa1" @@ -485328,15 +487321,15 @@ }, { "sim":542.0, - "partner":"4f0k" + "partner":"4f0m" }, { "sim":542.0, - "partner":"4f0m" + "partner":"4f0h" }, { "sim":542.0, - "partner":"4f0h" + "partner":"4f0k" }, { "sim":541.0, @@ -485380,15 +487373,15 @@ }, { "sim":316.0, - "partner":"3kdn" + "partner":"3wqp" }, { "sim":316.0, - "partner":"3wqp" + "partner":"3a13" }, { "sim":316.0, - "partner":"3a13" + "partner":"3kdn" }, { "sim":313.0, @@ -485420,15 +487413,15 @@ }, { "sim":190.0, - "partner":"5hjx" + "partner":"4lf1" }, { "sim":190.0, - "partner":"4lf1" + "partner":"4lf2" }, { "sim":190.0, - "partner":"4lf2" + "partner":"5hjx" }, { "sim":190.0, @@ -485456,11 +487449,11 @@ }, { "sim":183.0, - "partner":"7vwx" + "partner":"9rub" }, { "sim":183.0, - "partner":"9rub" + "partner":"7vwx" }, { "sim":183.0, @@ -485516,15 +487509,15 @@ }, { "sim":135.0, - "partner":"2oel" + "partner":"2oek" }, { "sim":135.0, - "partner":"2oem" + "partner":"2oel" }, { "sim":135.0, - "partner":"2oek" + "partner":"2oem" }, { "sim":122.0, @@ -485574,6 +487567,10 @@ } ], "struct_thr_sim_natural":[ + { + "sim":0.9524000287, + "partner":"3zxw" + }, { "sim":0.9559000134, "partner":"1rbl" @@ -485583,20 +487580,16 @@ "partner":"6ura" }, { - "sim":0.9546999931, - "partner":"1rbo" + "sim":0.9524999857, + "partner":"5iu0" }, { - "sim":0.9524000287, - "partner":"3zxw" + "sim":0.9546999931, + "partner":"1rbo" }, { "sim":0.9527000189, "partner":"1upm" - }, - { - "sim":0.9524999857, - "partner":"5iu0" } ], "seq_max_sim_designed":{ @@ -485691,72 +487684,72 @@ ], "subtitle":"Non-obligately l8s8-complex forming rubisco derived from ancestral sequence reconstruction and rational engineering in l8s8 complex with substitution e170n", "tags":[ - "ribulose 1", - "5-bisphosphate carboxylase\/oxydase", "rubisco", - "lyase" + "lyase", + "5-bisphosphate carboxylase\/oxydase", + "ribulose 1" ], "keywords":[ - "work", - "evolution", - "oxygen", - "remained", - "adapting", - "recapitulate", "rising", - "specificity", + "determinants", "carbon", - "use", - "ambient", + "specificity", + "structural", + "show", + "work", + "provides", + "recapitulate", "discriminate", - "biochemical", - "undesired", - "template", "photosynthetic", - "increased", - "strongly", - "emergence", + "carboxylation", "substrate", - "gain", - "illuminates", - "rubiscos", + "reconstruction", "approaches", - "became", + "side", + "environment", "subunit", - "ancestral", - "rubisco", - "oxygenated", - "determinants", - "carboxylation", - "provides", + "sheds", + "important", + "atmospheric", "retrace", - "light", - "show", - "elusive", - "reconstruction", - "essentiality", - "efficiency", + "dioxygen", "investigating", - "atmospheric", + "template", "interactions", - "using", - "levels", - "present", - "sheds", - "essential", - "function", - "sequence", + "ambient", + "undesired", + "strongly", + "increased", "adaptation", - "environment", + "event", + "biochemical", + "function", + "became", + "light", "dioxide", + "essentiality", + "remained", + "use", + "ancestral", + "gain", + "essential", + "rubiscos", + "sequence", + "oxygen", + "levels", + "oxygenated", + "emergence", + "evolution", + "rubisco", + "efficiency", + "present", + "adapting", + "elusive", "organisms", - "accessory", "gained", - "side", - "structural", - "event", - "important", - "dioxygen" + "accessory", + "using", + "illuminates" ], "release_date":"2022-10-12", "publication":"\"Evolution of increased complexity and specificity at the dawn of form I Rubiscos\", Science, 378, 155-160", @@ -485787,14 +487780,14 @@ "previous_design":"7qsz", "next_design":"7qvi", "seq_thr_sim_designed":[ - { - "sim":774.0, - "partner":"7qsw" - }, { "sim":936.0, "partner":"8qmw" }, + { + "sim":774.0, + "partner":"7qsw" + }, { "sim":943.0, "partner":"7qsy" @@ -485839,7 +487832,7 @@ }, { "sim":668.0, - "partner":"2wvw" + "partner":"6hbc" }, { "sim":668.0, @@ -485847,7 +487840,7 @@ }, { "sim":668.0, - "partner":"6hbc" + "partner":"2wvw" }, { "sim":668.0, @@ -485857,10 +487850,6 @@ "sim":668.0, "partner":"6lrs" }, - { - "sim":668.0, - "partner":"6z1f" - }, { "sim":668.0, "partner":"6z1g" @@ -485873,6 +487862,10 @@ "sim":668.0, "partner":"7xsd" }, + { + "sim":668.0, + "partner":"6z1f" + }, { "sim":668.0, "partner":"6kkm" @@ -485947,11 +487940,11 @@ }, { "sim":639.0, - "partner":"2vdh" + "partner":"1upm" }, { "sim":639.0, - "partner":"1upm" + "partner":"8ruc" }, { "sim":639.0, @@ -485959,7 +487952,7 @@ }, { "sim":639.0, - "partner":"8ruc" + "partner":"2vdh" }, { "sim":639.0, @@ -485967,7 +487960,7 @@ }, { "sim":638.0, - "partner":"7jn4" + "partner":"2v69" }, { "sim":638.0, @@ -485975,7 +487968,7 @@ }, { "sim":638.0, - "partner":"2v69" + "partner":"1uwa" }, { "sim":638.0, @@ -485985,29 +487978,25 @@ "sim":638.0, "partner":"1ir2" }, - { - "sim":638.0, - "partner":"1uwa" - }, { "sim":638.0, "partner":"1uzh" }, { "sim":638.0, - "partner":"1gk8" + "partner":"1rxo" }, { "sim":638.0, - "partner":"1rxo" + "partner":"7jfo" }, { "sim":638.0, - "partner":"1rco" + "partner":"1gk8" }, { "sim":638.0, - "partner":"7jfo" + "partner":"1rco" }, { "sim":638.0, @@ -486025,6 +488014,10 @@ "sim":638.0, "partner":"1uzd" }, + { + "sim":638.0, + "partner":"7jn4" + }, { "sim":638.0, "partner":"1aa1" @@ -486075,15 +488068,15 @@ }, { "sim":542.0, - "partner":"4f0k" + "partner":"4f0m" }, { "sim":542.0, - "partner":"4f0m" + "partner":"4f0h" }, { "sim":542.0, - "partner":"4f0h" + "partner":"4f0k" }, { "sim":541.0, @@ -486127,15 +488120,15 @@ }, { "sim":316.0, - "partner":"3kdn" + "partner":"3wqp" }, { "sim":316.0, - "partner":"3wqp" + "partner":"3a13" }, { "sim":316.0, - "partner":"3a13" + "partner":"3kdn" }, { "sim":313.0, @@ -486167,15 +488160,15 @@ }, { "sim":190.0, - "partner":"5hjx" + "partner":"4lf1" }, { "sim":190.0, - "partner":"4lf1" + "partner":"4lf2" }, { "sim":190.0, - "partner":"4lf2" + "partner":"5hjx" }, { "sim":190.0, @@ -486203,11 +488196,11 @@ }, { "sim":183.0, - "partner":"7vwx" + "partner":"9rub" }, { "sim":183.0, - "partner":"9rub" + "partner":"7vwx" }, { "sim":183.0, @@ -486263,15 +488256,15 @@ }, { "sim":135.0, - "partner":"2oel" + "partner":"2oek" }, { "sim":135.0, - "partner":"2oem" + "partner":"2oel" }, { "sim":135.0, - "partner":"2oek" + "partner":"2oem" }, { "sim":122.0, @@ -486288,16 +488281,16 @@ ], "struct_thr_sim_designed":[ { - "sim":0.9991999865, - "partner":"7qsy" + "sim":0.9998000264, + "partner":"8qmw" }, { "sim":0.9980000257, "partner":"7qsw" }, { - "sim":0.9998000264, - "partner":"8qmw" + "sim":0.9991999865, + "partner":"7qsy" }, { "sim":0.9983000159, @@ -486307,31 +488300,27 @@ "sim":0.9941999912, "partner":"7qsv" }, - { - "sim":0.9958999753, - "partner":"8qmv" - }, { "sim":0.9986000061, "partner":"7qsx" }, + { + "sim":0.9958999753, + "partner":"8qmv" + }, { "sim":0.9779000282, "partner":"7qvi" } ], "struct_thr_sim_natural":[ - { - "sim":0.9592999816, - "partner":"1wdd" - }, { "sim":0.9599000216, "partner":"5iu0" }, { - "sim":0.9599999785, - "partner":"1rbl" + "sim":0.9592999816, + "partner":"1wdd" }, { "sim":0.9550999999, @@ -486341,6 +488330,18 @@ "sim":0.9631999731, "partner":"1rbo" }, + { + "sim":0.9617000222, + "partner":"2v68" + }, + { + "sim":0.9617000222, + "partner":"1uw9" + }, + { + "sim":0.9599999785, + "partner":"1rbl" + }, { "sim":0.9596999884, "partner":"2v67" @@ -486349,18 +488350,10 @@ "sim":0.9595000148, "partner":"1uwa" }, - { - "sim":0.9617000222, - "partner":"2v68" - }, { "sim":0.9588000178, "partner":"1gk8" }, - { - "sim":0.9617000222, - "partner":"1uw9" - }, { "sim":0.9566000104, "partner":"3zxw" @@ -486466,72 +488459,72 @@ ], "subtitle":"Fiber-forming rubisco derived from ancestral sequence reconstruction and rational engineering", "tags":[ - "ribulose 1", - "5-bisphosphate carboxylase\/oxydase", "rubisco", - "lyase" + "lyase", + "5-bisphosphate carboxylase\/oxydase", + "ribulose 1" ], "keywords":[ - "work", - "evolution", - "oxygen", - "remained", - "adapting", - "recapitulate", "rising", - "specificity", + "determinants", "carbon", - "use", - "ambient", + "specificity", + "structural", + "show", + "work", + "provides", + "recapitulate", "discriminate", - "biochemical", - "undesired", - "template", "photosynthetic", - "increased", - "strongly", - "emergence", + "carboxylation", "substrate", - "gain", - "illuminates", - "rubiscos", + "reconstruction", "approaches", - "became", + "side", + "environment", "subunit", - "ancestral", - "rubisco", - "oxygenated", - "determinants", - "carboxylation", - "provides", + "sheds", + "important", + "atmospheric", "retrace", - "light", - "show", - "elusive", - "reconstruction", - "essentiality", - "efficiency", + "dioxygen", "investigating", - "atmospheric", + "template", "interactions", - "using", - "levels", - "present", - "sheds", - "essential", - "function", - "sequence", + "ambient", + "undesired", + "strongly", + "increased", "adaptation", - "environment", + "event", + "biochemical", + "function", + "became", + "light", "dioxide", + "essentiality", + "remained", + "use", + "ancestral", + "gain", + "essential", + "rubiscos", + "sequence", + "oxygen", + "levels", + "oxygenated", + "emergence", + "evolution", + "rubisco", + "efficiency", + "present", + "adapting", + "elusive", "organisms", - "accessory", "gained", - "side", - "structural", - "event", - "important", - "dioxygen" + "accessory", + "using", + "illuminates" ], "release_date":"2022-10-12", "publication":"\"Evolution of increased complexity and specificity at the dawn of form I Rubiscos\", Science, 378, 155-160", @@ -486564,19 +488557,19 @@ "seq_thr_sim_designed":[ { "sim":942.0, - "partner":"7qsy" + "partner":"7qsx" }, { "sim":942.0, - "partner":"7qsx" + "partner":"7qsy" }, { "sim":940.0, - "partner":"7qt1" + "partner":"7qsz" }, { "sim":940.0, - "partner":"7qsz" + "partner":"7qt1" }, { "sim":935.0, @@ -486618,7 +488611,7 @@ }, { "sim":671.0, - "partner":"2wvw" + "partner":"6hbc" }, { "sim":671.0, @@ -486626,7 +488619,7 @@ }, { "sim":671.0, - "partner":"6hbc" + "partner":"2wvw" }, { "sim":671.0, @@ -486636,10 +488629,6 @@ "sim":671.0, "partner":"6lrs" }, - { - "sim":671.0, - "partner":"6z1f" - }, { "sim":671.0, "partner":"6z1g" @@ -486652,6 +488641,10 @@ "sim":671.0, "partner":"7xsd" }, + { + "sim":671.0, + "partner":"6z1f" + }, { "sim":653.0, "partner":"4hhh" @@ -486722,11 +488715,11 @@ }, { "sim":642.0, - "partner":"2vdh" + "partner":"1upm" }, { "sim":642.0, - "partner":"1upm" + "partner":"8ruc" }, { "sim":642.0, @@ -486734,7 +488727,7 @@ }, { "sim":642.0, - "partner":"8ruc" + "partner":"2vdh" }, { "sim":642.0, @@ -486742,7 +488735,7 @@ }, { "sim":641.0, - "partner":"7jn4" + "partner":"2v69" }, { "sim":641.0, @@ -486750,7 +488743,7 @@ }, { "sim":641.0, - "partner":"2v69" + "partner":"1uwa" }, { "sim":641.0, @@ -486760,29 +488753,25 @@ "sim":641.0, "partner":"1ir2" }, - { - "sim":641.0, - "partner":"1uwa" - }, { "sim":641.0, "partner":"1uzh" }, { "sim":641.0, - "partner":"1gk8" + "partner":"1rxo" }, { "sim":641.0, - "partner":"1rxo" + "partner":"7jfo" }, { "sim":641.0, - "partner":"1rco" + "partner":"1gk8" }, { "sim":641.0, - "partner":"7jfo" + "partner":"1rco" }, { "sim":641.0, @@ -486800,6 +488789,10 @@ "sim":641.0, "partner":"1uzd" }, + { + "sim":641.0, + "partner":"7jn4" + }, { "sim":641.0, "partner":"1aa1" @@ -486854,15 +488847,15 @@ }, { "sim":537.0, - "partner":"4f0k" + "partner":"4f0m" }, { "sim":537.0, - "partner":"4f0m" + "partner":"4f0h" }, { "sim":537.0, - "partner":"4f0h" + "partner":"4f0k" }, { "sim":514.0, @@ -486902,11 +488895,11 @@ }, { "sim":317.0, - "partner":"3kdn" + "partner":"3a13" }, { "sim":317.0, - "partner":"3a13" + "partner":"3kdn" }, { "sim":316.0, @@ -486942,15 +488935,15 @@ }, { "sim":190.0, - "partner":"5hjx" + "partner":"4lf1" }, { "sim":190.0, - "partner":"4lf1" + "partner":"4lf2" }, { "sim":190.0, - "partner":"4lf2" + "partner":"5hjx" }, { "sim":190.0, @@ -486978,11 +488971,11 @@ }, { "sim":183.0, - "partner":"7vwx" + "partner":"9rub" }, { "sim":183.0, - "partner":"9rub" + "partner":"7vwx" }, { "sim":183.0, @@ -487038,15 +489031,15 @@ }, { "sim":134.0, - "partner":"2oel" + "partner":"2oek" }, { "sim":134.0, - "partner":"2oem" + "partner":"2oel" }, { "sim":134.0, - "partner":"2oek" + "partner":"2oem" }, { "sim":122.0, @@ -487062,25 +489055,25 @@ } ], "struct_thr_sim_designed":[ - { - "sim":0.9887999892, - "partner":"7qsz" - }, { "sim":0.9880999923, "partner":"7qsx" }, { - "sim":0.9844999909, - "partner":"7qsv" + "sim":0.9887999892, + "partner":"7qsz" + }, + { + "sim":0.9840999842, + "partner":"8qmv" }, { "sim":0.9860000014, "partner":"7qsy" }, { - "sim":0.9840999842, - "partner":"8qmv" + "sim":0.9844999909, + "partner":"7qsv" }, { "sim":0.9825000167, @@ -487100,7 +489093,7 @@ ], "seq_max_sim_designed":{ "sim":942.0, - "partner":"7qsy" + "partner":"7qsx" }, "seq_max_sim_natural":{ "sim":687.0, @@ -487158,10 +489151,10 @@ ], "subtitle":"Cc-type2-(ugue)4", "tags":[ - "aib", - "de novo protein", "coiled coil", "2-aminoisobutyric acid", + "aib", + "de novo protein", "hexamer" ], "keywords":[ @@ -487272,11 +489265,11 @@ ], "subtitle":"Cc-type2-(ue)4", "tags":[ - "antiparallel", - "aib", - "de novo protein", "coiled coil", "2-aminoisobutyric acid", + "aib", + "de novo protein", + "antiparallel", "hexamer" ], "keywords":[ @@ -487326,6 +489319,26 @@ "sim":1.0, "partner":"4pna" }, + { + "sim":1.0, + "partner":"7nfg" + }, + { + "sim":1.0, + "partner":"6yb2" + }, + { + "sim":1.0, + "partner":"7bas" + }, + { + "sim":1.0, + "partner":"7bav" + }, + { + "sim":1.0, + "partner":"7bau" + }, { "sim":1.0, "partner":"5ez8" @@ -487354,18 +489367,10 @@ "sim":1.0, "partner":"4pn9" }, - { - "sim":1.0, - "partner":"7bas" - }, { "sim":1.0, "partner":"6eiz" }, - { - "sim":1.0, - "partner":"7bav" - }, { "sim":1.0, "partner":"7nfh" @@ -487402,10 +489407,6 @@ "sim":0.966899991, "partner":"7nff" }, - { - "sim":1.0, - "partner":"7nfg" - }, { "sim":1.0, "partner":"8a09" @@ -487418,18 +489419,10 @@ "sim":0.966899991, "partner":"8b16" }, - { - "sim":1.0, - "partner":"6yb2" - }, { "sim":1.0, "partner":"7bat" }, - { - "sim":1.0, - "partner":"7bau" - }, { "sim":1.0, "partner":"7baw" @@ -487516,10 +489509,10 @@ "subtitle":"Cc-type1-(ubuc)4", "tags":[ "trimer", - "aib", - "de novo protein", "coiled coil", - "2-aminoisobutyric acid" + "2-aminoisobutyric acid", + "aib", + "de novo protein" ], "keywords":[ "description", @@ -487629,11 +489622,11 @@ ], "subtitle":"Cc-type2-(ug)4", "tags":[ - "aib", - "de novo protein", "coiled coil", "2-aminoisobutyric acid", - "pentamer" + "pentamer", + "aib", + "de novo protein" ], "keywords":[ "description", @@ -487712,7 +489705,7 @@ }, { "sim":1.0, - "partner":"7nfg" + "partner":"7baw" }, { "sim":1.0, @@ -487724,12 +489717,16 @@ }, { "sim":1.0, - "partner":"7baw" + "partner":"7nfg" }, { "sim":1.0, "partner":"7nfi" }, + { + "sim":1.0, + "partner":"8b16" + }, { "sim":1.0, "partner":"5ez8" @@ -487743,20 +489740,28 @@ "partner":"7nff" }, { - "sim":1.0, - "partner":"8b16" + "sim":0.9703999758, + "partner":"7nfo" }, { "sim":1.0, "partner":"6yb2" }, { - "sim":0.9703999758, - "partner":"7nfo" + "sim":1.0, + "partner":"6zt1" + }, + { + "sim":0.9642999768, + "partner":"7nfm" }, { "sim":1.0, - "partner":"6zt1" + "partner":"6g6f" + }, + { + "sim":1.0, + "partner":"6g6g" }, { "sim":0.9684000015, @@ -487767,16 +489772,12 @@ "partner":"7nfl" }, { - "sim":0.9642999768, - "partner":"7nfm" - }, - { - "sim":1.0, - "partner":"6g6f" + "sim":0.9642000198, + "partner":"6eik" }, { - "sim":1.0, - "partner":"6g6g" + "sim":0.9624000192, + "partner":"5ez9" }, { "sim":0.9977999926, @@ -487814,17 +489815,9 @@ "sim":0.953700006, "partner":"7nfk" }, - { - "sim":0.9642000198, - "partner":"6eik" - }, { "sim":0.953700006, "partner":"7bo9" - }, - { - "sim":0.9624000192, - "partner":"5ez9" } ], "struct_thr_sim_natural":[ @@ -487838,7 +489831,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"7bas" + "partner":"7qwe" }, "struct_max_sim_natural":[ @@ -487887,11 +489880,11 @@ ], "subtitle":"Cc-type2-(ug)4", "tags":[ - "aib", - "de novo protein", "coiled coil", "2-aminoisobutyric acid", - "pentamer" + "pentamer", + "aib", + "de novo protein" ], "keywords":[ "description", @@ -487936,21 +489929,17 @@ "sim":1.0, "partner":"7qwd" }, - { - "sim":1.0, - "partner":"7a1t" - }, { "sim":1.0, "partner":"7bas" }, { "sim":1.0, - "partner":"7bav" + "partner":"7a1t" }, { - "sim":1.0, - "partner":"7bim" + "sim":0.9660000205, + "partner":"8b15" }, { "sim":1.0, @@ -487960,82 +489949,74 @@ "sim":0.9825000167, "partner":"6eiz" }, - { - "sim":0.9660000205, - "partner":"8b15" - }, { "sim":1.0, - "partner":"4pna" - }, - { - "sim":0.993900001, - "partner":"7bat" + "partner":"7bim" }, { "sim":1.0, - "partner":"7baw" + "partner":"7bav" }, { "sim":0.9703999758, "partner":"7bau" }, { - "sim":1.0, - "partner":"7nfg" + "sim":0.993900001, + "partner":"7bat" }, { "sim":1.0, - "partner":"7nfj" + "partner":"4pna" }, { "sim":1.0, - "partner":"6g6f" + "partner":"8b16" }, { "sim":1.0, - "partner":"7nfi" + "partner":"7nfj" }, { "sim":1.0, - "partner":"8b16" + "partner":"7baw" + }, + { + "sim":0.9764000177, + "partner":"7nfo" }, { "sim":1.0, "partner":"5ez8" }, { - "sim":0.9980999827, - "partner":"6g6d" + "sim":1.0, + "partner":"6g6f" }, { - "sim":0.9764000177, - "partner":"7nfo" + "sim":0.9711999893, + "partner":"7nfh" }, { - "sim":0.9959999919, - "partner":"7nff" + "sim":0.953700006, + "partner":"7nfk" }, { "sim":1.0, - "partner":"6yb2" + "partner":"6zt1" }, { "sim":1.0, - "partner":"6zt1" + "partner":"7nfg" }, { - "sim":0.9602000117, - "partner":"7nfm" + "sim":0.9980999827, + "partner":"6g6d" }, { "sim":1.0, "partner":"6g6g" }, - { - "sim":0.9711999893, - "partner":"7nfh" - }, { "sim":1.0, "partner":"7nfl" @@ -488045,16 +490026,16 @@ "partner":"6eik" }, { - "sim":0.962100029, - "partner":"5ez9" + "sim":0.953700006, + "partner":"7bo9" }, { - "sim":0.9937999845, - "partner":"6g6a" + "sim":1.0, + "partner":"6yb2" }, { - "sim":1.0, - "partner":"7nfp" + "sim":0.9959999919, + "partner":"7nff" }, { "sim":0.9970999956, @@ -488064,6 +490045,26 @@ "sim":1.0, "partner":"6g67" }, + { + "sim":1.0, + "partner":"7nfp" + }, + { + "sim":1.0, + "partner":"7nfi" + }, + { + "sim":0.9602000117, + "partner":"7nfm" + }, + { + "sim":0.962100029, + "partner":"5ez9" + }, + { + "sim":0.9937999845, + "partner":"6g6a" + }, { "sim":0.9642999768, "partner":"5eza" @@ -488075,14 +490076,6 @@ { "sim":1.0, "partner":"6g6c" - }, - { - "sim":0.953700006, - "partner":"7nfk" - }, - { - "sim":0.953700006, - "partner":"7bo9" } ], "struct_thr_sim_natural":[ @@ -488173,100 +490166,100 @@ ], "subtitle":"Solution structure of tk-hefu-11", "tags":[ - "protein", "toxin", - "kv1.6 blocker", - "tk-hefu-11" + "tk-hefu-11", + "protein", + "kv1.6 blocker" ], "keywords":[ - "simplistic", - "significance", - "part", + "affinity", "v", - "nm", - "channels", - "studies", - "low", - "acid", - "peptide", - "expressed", - "enhance", - "proposed", - "substitutions", - "nervous", + "molecular", "show", - "based", - "interactions", - "structure", - "turns", - "widespread", - "able", - "however", - "affinity", - "even", - "blockage", - "k", - "solved", - "produce", "number", - "used", - "highly", - "little", - "furthermore", - "dynamics", - "concerning", - "potassium", + "quite", + "widespread", + "substitutions", + "explain", + "acid", "ligands", - "shows", - "designer", - "previously", - "investigate", - "data", - "obtained", - "molecular", - "demonstrated", - "amino", - "higher", "presenting", - "artificial", - "surprisingly", - "among", - "useful", - "functions", + "hope", + "little", "physiological", + "channel", + "k", + "submicromolar", + "shows", + "however", + "enhance", + "able", + "due", + "furthermore", "specific", - "activity", - "result", - "scarcity", - "conversely", - "quite", - "present", - "high", - "increase", - "known", - "hope", - "range", - "one", - "lack", + "50", + "functions", + "useful", "showing", - "channel", - "peptides", "constructed", - "ec", + "part", + "low", + "turns", + "scaffold", + "highly", + "higher", + "since", + "peptide", + "investigate", + "obtained", + "lack", + "surprisingly", + "increase", + "even", + "used", + "nervous", + "produce", + "nm", + "blockage", + "selective", + "potency", + "simplistic", "selectivity", - "due", + "amino", + "designer", "system", - "50", + "demonstrated", + "solved", + "channels", + "peptides", + "potassium", + "scarcity", + "present", + "range", + "proposed", + "dynamics", "determinants", + "one", + "significance", + "conversely", + "expressed", + "concerning", + "previously", + "based", + "structure", + "among", "isoforms", - "scaffold", - "selective", - "explain", - "submicromolar", - "potency", "block", + "interactions", + "known", "dramatic", - "since" + "artificial", + "high", + "activity", + "result", + "studies", + "data", + "ec" ], "release_date":"2022-09-21", "publication":"\"Artificial pore blocker acts specifically on voltage-gated potassium channel isoform K V 1.6\", J.Biol.Chem., 298, 102467-102467", @@ -488378,118 +490371,118 @@ ], "subtitle":"Solution structure of the designed armadillo repeat protein n(a4)m4c(aii) refined by pseudocontact shifts", "tags":[ - "designed armadillo repeat protein", "peptide binding protein", - "repeat protein" + "repeat protein", + "designed armadillo repeat protein" ], "keywords":[ - "exchange", - "containing", - "remarkably", - "unfolding", - "aggregation", + "superior", + "repeats", + "recognition", + "optimized", + "hydrophobic", + "repeat", + "overcome", + "show", "orders", - "protect", + "core", + "new", + "protein", + "partially", + "increased", "biochemical", - "time", - "designed", - "basic", - "local", - "improved", - "experimentally", + "linear", + "flanked", + "binding", + "unfolding", + "subsequent", + "armrps", + "resonance", + "circular", + "composed", + "original", + "nuclear", "crystal", - "determined", - "correlates", - "show", - "software", - "overcome", - "enhanced", + "using", + "remarkably", "conformation", - "structure", - "repeat", + "starting", "computationally", + "experimentally", + "armadillo", + "overall", + "epitopes", + "aggregation", + "proteolysis", "weakened", - "instability", - "novel", - "starting", - "armrps", - "darmrp", - "composed", - "original", - "partially", + "level", + "magnetic", + "stability", "proteins", - "employed", - "models", - "impeded", - "linear", - "feature", - "resulting", + "packing", + "several", + "consensus", + "modular", + "hydrogen", "small", - "used", - "recognition", - "darmrps", - "nuclear", + "four", + "correlates", + "local", + "design", + "enhanced", "onto", + "spectroscopy", "therapeutics", - "assumes", - "flanked", - "capping", - "solution", - "resonance", - "armadillo", - "revealed", - "circular", + "used", + "feature", "research", - "magnitude", - "first", - "solvent", - "hydrogen", - "consensus", - "previously", - "stability", - "fraction", - "verified", - "subsequent", - "vulnerable", - "four", - "increased", - "mode", - "engineer", "application", - "several", - "design", - "core", + "rosetta", + "experiments", + "instability", + "vulnerable", "reduced", - "exposure", - "using", "resistance", - "hydrophobic", - "proteolysis", - "high", - "repeats", - "epitopes", - "packing", - "important", - "overall", - "magnetic", - "optimized", + "mode", + "improved", + "solution", "renders", - "experiments", - "rosetta", - "modular", - "spectroscopy", + "time", + "exchange", + "magnitude", "unfolded", - "problem", - "binding", - "protein", + "assumes", + "engineer", "refined", - "superior", - "diagnostics", - "dichroism", - "internal", + "designed", + "verified", + "employed", + "models", + "basic", + "revealed", + "first", + "previously", + "exposure", + "important", + "structure", + "determined", + "resulting", "biophysical", - "level", - "new" + "capping", + "impeded", + "darmrps", + "internal", + "software", + "high", + "fraction", + "dichroism", + "solvent", + "darmrp", + "protect", + "problem", + "containing", + "diagnostics", + "novel" ], "release_date":"2022-06-22", "publication":"\"Improved Repeat Protein Stability by Combined Consensus and Computational Protein Design\", Biochemistry, 62, 318-329", @@ -488534,11 +490527,11 @@ }, { "sim":434.0, - "partner":"5mfh" + "partner":"5aei" }, { "sim":434.0, - "partner":"5mfn" + "partner":"5mfe" }, { "sim":434.0, @@ -488550,11 +490543,11 @@ }, { "sim":434.0, - "partner":"5aei" + "partner":"5mfh" }, { "sim":434.0, - "partner":"5mfe" + "partner":"5mfn" }, { "sim":431.0, @@ -488634,11 +490627,11 @@ }, { "sim":278.0, - "partner":"5mfi" + "partner":"5mfj" }, { "sim":278.0, - "partner":"5mfj" + "partner":"5mfi" }, { "sim":236.0, @@ -488714,10 +490707,6 @@ "sim":524.0, "partner":"6vam" }, - { - "sim":518.0, - "partner":"6uz3" - }, { "sim":518.0, "partner":"7k18" @@ -488730,6 +490719,10 @@ "sim":518.0, "partner":"6uz0" }, + { + "sim":518.0, + "partner":"6uz3" + }, { "sim":515.0, "partner":"7wji" @@ -488742,10 +490735,6 @@ "sim":514.0, "partner":"4xvp" }, - { - "sim":513.0, - "partner":"7bym" - }, { "sim":513.0, "partner":"7byn" @@ -488755,8 +490744,8 @@ "partner":"7byl" }, { - "sim":509.0, - "partner":"5ma4" + "sim":513.0, + "partner":"7bym" }, { "sim":509.0, @@ -488786,6 +490775,10 @@ "sim":509.0, "partner":"5ma3" }, + { + "sim":509.0, + "partner":"5ma4" + }, { "sim":509.0, "partner":"6val" @@ -488972,11 +490965,11 @@ }, { "sim":499.0, - "partner":"1rmo" + "partner":"4kex" }, { "sim":499.0, - "partner":"4kex" + "partner":"1rmo" }, { "sim":498.0, @@ -488992,15 +490985,15 @@ }, { "sim":497.0, - "partner":"2q6p" + "partner":"2okw" }, { "sim":497.0, - "partner":"2okw" + "partner":"2oky" }, { "sim":497.0, - "partner":"2oky" + "partner":"2q6p" }, { "sim":497.0, @@ -489150,18 +491143,6 @@ "sim":495.0, "partner":"2wsn" }, - { - "sim":495.0, - "partner":"3dqc" - }, - { - "sim":495.0, - "partner":"3dqd" - }, - { - "sim":495.0, - "partner":"3dqe" - }, { "sim":495.0, "partner":"3dqf" @@ -489256,11 +491237,19 @@ }, { "sim":495.0, - "partner":"7amu" + "partner":"3dqc" }, { "sim":495.0, - "partner":"3sv5" + "partner":"3dqd" + }, + { + "sim":495.0, + "partner":"3dqe" + }, + { + "sim":495.0, + "partner":"7amu" }, { "sim":495.0, @@ -489278,6 +491267,10 @@ "sim":495.0, "partner":"3st0" }, + { + "sim":495.0, + "partner":"3sv5" + }, { "sim":495.0, "partner":"7sun" @@ -489296,27 +491289,27 @@ }, { "sim":494.0, - "partner":"1q4c" + "partner":"1z1p" }, { "sim":494.0, - "partner":"1q4d" + "partner":"1w7s" }, { "sim":494.0, - "partner":"1z1p" + "partner":"1z1q" }, { "sim":494.0, - "partner":"1w7s" + "partner":"1s6z" }, { "sim":494.0, - "partner":"1z1q" + "partner":"1q4c" }, { "sim":494.0, - "partner":"1s6z" + "partner":"1q4d" }, { "sim":494.0, @@ -489346,10 +491339,6 @@ "sim":493.0, "partner":"6vio" }, - { - "sim":492.0, - "partner":"1q4e" - }, { "sim":492.0, "partner":"2qle" @@ -489372,16 +491361,20 @@ }, { "sim":492.0, - "partner":"1hcj" + "partner":"2dug" }, { "sim":492.0, - "partner":"2dug" + "partner":"1hcj" }, { "sim":492.0, "partner":"2duh" }, + { + "sim":492.0, + "partner":"1q4e" + }, { "sim":492.0, "partner":"1emc" @@ -489402,6 +491395,10 @@ "sim":492.0, "partner":"1huy" }, + { + "sim":492.0, + "partner":"6gqg" + }, { "sim":492.0, "partner":"6gqh" @@ -489418,10 +491415,6 @@ "sim":492.0, "partner":"6go9" }, - { - "sim":492.0, - "partner":"6gqg" - }, { "sim":492.0, "partner":"5hge" @@ -489448,11 +491441,11 @@ }, { "sim":491.0, - "partner":"1bfp" + "partner":"2wur" }, { "sim":491.0, - "partner":"2wur" + "partner":"1bfp" }, { "sim":491.0, @@ -489540,11 +491533,11 @@ }, { "sim":488.0, - "partner":"5ox9" + "partner":"8iz0" }, { "sim":488.0, - "partner":"8iz0" + "partner":"5ox9" }, { "sim":488.0, @@ -489576,15 +491569,15 @@ }, { "sim":487.0, - "partner":"2ye0" + "partner":"6yln" }, { "sim":487.0, - "partner":"6yln" + "partner":"3ztf" }, { "sim":487.0, - "partner":"3ztf" + "partner":"2ye0" }, { "sim":487.0, @@ -489606,10 +491599,6 @@ "sim":486.0, "partner":"2hgd" }, - { - "sim":486.0, - "partner":"2ye1" - }, { "sim":486.0, "partner":"8iyz" @@ -489619,12 +491608,8 @@ "partner":"4b5y" }, { - "sim":485.0, - "partner":"7cd7" - }, - { - "sim":485.0, - "partner":"7cd8" + "sim":486.0, + "partner":"2ye1" }, { "sim":485.0, @@ -489632,23 +491617,23 @@ }, { "sim":485.0, - "partner":"1f09" + "partner":"8jl2" }, { "sim":485.0, - "partner":"8jl2" + "partner":"8jkc" }, { "sim":485.0, - "partner":"1f0b" + "partner":"8jkg" }, { "sim":485.0, - "partner":"8jkc" + "partner":"1f09" }, { "sim":485.0, - "partner":"8jkg" + "partner":"1f0b" }, { "sim":485.0, @@ -489660,7 +491645,11 @@ }, { "sim":485.0, - "partner":"2g6e" + "partner":"7cd7" + }, + { + "sim":485.0, + "partner":"7cd8" }, { "sim":485.0, @@ -489692,15 +491681,15 @@ }, { "sim":485.0, - "partner":"6ylo" + "partner":"2g6e" }, { "sim":485.0, - "partner":"4ar7" + "partner":"6ylo" }, { - "sim":484.0, - "partner":"2hrs" + "sim":485.0, + "partner":"4ar7" }, { "sim":484.0, @@ -489716,7 +491705,7 @@ }, { "sim":484.0, - "partner":"1kyp" + "partner":"2hrs" }, { "sim":484.0, @@ -489742,6 +491731,10 @@ "sim":484.0, "partner":"1yjf" }, + { + "sim":484.0, + "partner":"1kyp" + }, { "sim":484.0, "partner":"6lr7" @@ -489784,11 +491777,11 @@ }, { "sim":482.0, - "partner":"1qyq" + "partner":"6ir7" }, { "sim":482.0, - "partner":"6ir7" + "partner":"1qyq" }, { "sim":482.0, @@ -489840,19 +491833,19 @@ }, { "sim":482.0, - "partner":"7a7o" + "partner":"7a8l" }, { "sim":482.0, - "partner":"7a7p" + "partner":"7a8m" }, { "sim":482.0, - "partner":"7a8l" + "partner":"7a7o" }, { "sim":482.0, - "partner":"7a8m" + "partner":"7a7p" }, { "sim":482.0, @@ -489916,27 +491909,27 @@ }, { "sim":481.0, - "partner":"7a7m" + "partner":"7a83" }, { "sim":481.0, - "partner":"7a8d" + "partner":"7a84" }, { "sim":481.0, - "partner":"7a7n" + "partner":"7a7m" }, { "sim":481.0, - "partner":"7a8e" + "partner":"7a8d" }, { "sim":481.0, - "partner":"7a83" + "partner":"7a7n" }, { "sim":481.0, - "partner":"7a84" + "partner":"7a8e" }, { "sim":481.0, @@ -489944,19 +491937,15 @@ }, { "sim":481.0, - "partner":"7v80" - }, - { - "sim":481.0, - "partner":"7v87" + "partner":"7v81" }, { "sim":481.0, - "partner":"7v81" + "partner":"7v88" }, { "sim":481.0, - "partner":"7v88" + "partner":"8xal" }, { "sim":481.0, @@ -489968,15 +491957,15 @@ }, { "sim":481.0, - "partner":"7v83" + "partner":"7edj" }, { "sim":481.0, - "partner":"7v8a" + "partner":"7v83" }, { "sim":481.0, - "partner":"7edj" + "partner":"7v8a" }, { "sim":481.0, @@ -489998,6 +491987,14 @@ "sim":481.0, "partner":"7v86" }, + { + "sim":481.0, + "partner":"7v80" + }, + { + "sim":481.0, + "partner":"7v87" + }, { "sim":481.0, "partner":"4rh7" @@ -490028,19 +492025,19 @@ }, { "sim":480.0, - "partner":"4xov" + "partner":"7a7z" }, { "sim":480.0, - "partner":"4xow" + "partner":"7a80" }, { "sim":480.0, - "partner":"7a7z" + "partner":"4xov" }, { "sim":480.0, - "partner":"7a80" + "partner":"4xow" }, { "sim":480.0, @@ -490078,10 +492075,6 @@ "sim":479.0, "partner":"6mb2" }, - { - "sim":479.0, - "partner":"7a8f" - }, { "sim":479.0, "partner":"7a81" @@ -490098,6 +492091,10 @@ "sim":479.0, "partner":"7a8c" }, + { + "sim":479.0, + "partner":"7a8f" + }, { "sim":479.0, "partner":"7bwn" @@ -490116,11 +492113,11 @@ }, { "sim":478.0, - "partner":"1rmp" + "partner":"1rmm" }, { "sim":478.0, - "partner":"1rmm" + "partner":"1rmp" }, { "sim":478.0, @@ -490130,10 +492127,6 @@ "sim":478.0, "partner":"2b3p" }, - { - "sim":478.0, - "partner":"7a8g" - }, { "sim":478.0, "partner":"7a8h" @@ -490154,14 +492147,34 @@ "sim":478.0, "partner":"7a7y" }, + { + "sim":478.0, + "partner":"7a8g" + }, { "sim":477.0, - "partner":"5dph" + "partner":"8rlb" + }, + { + "sim":477.0, + "partner":"8rlc" + }, + { + "sim":477.0, + "partner":"8rle" + }, + { + "sim":477.0, + "partner":"8rl9" }, { "sim":477.0, "partner":"6dq1" }, + { + "sim":477.0, + "partner":"5dph" + }, { "sim":477.0, "partner":"8qwj" @@ -490448,11 +492461,11 @@ }, { "sim":468.0, - "partner":"4p1q" + "partner":"6jgh" }, { "sim":468.0, - "partner":"6jgh" + "partner":"4p1q" }, { "sim":468.0, @@ -490504,11 +492517,11 @@ }, { "sim":466.0, - "partner":"3lva" + "partner":"7pca" }, { "sim":466.0, - "partner":"7pca" + "partner":"3lva" }, { "sim":465.0, @@ -490552,11 +492565,11 @@ }, { "sim":458.0, - "partner":"5btt" + "partner":"5nhn" }, { "sim":458.0, - "partner":"5nhn" + "partner":"5btt" }, { "sim":456.0, @@ -490666,10 +492679,6 @@ "sim":435.0, "partner":"4w7e" }, - { - "sim":433.0, - "partner":"4w6m" - }, { "sim":433.0, "partner":"4w6n" @@ -490698,6 +492707,10 @@ "sim":433.0, "partner":"4w6l" }, + { + "sim":433.0, + "partner":"4w6m" + }, { "sim":432.0, "partner":"5z6y" @@ -490794,10 +492807,6 @@ "sim":414.0, "partner":"6b7r" }, - { - "sim":411.0, - "partner":"6wvi" - }, { "sim":411.0, "partner":"6wv8" @@ -490814,6 +492823,10 @@ "sim":411.0, "partner":"6wvb" }, + { + "sim":411.0, + "partner":"6wvi" + }, { "sim":405.0, "partner":"4pls" @@ -490986,14 +492999,6 @@ "sim":316.0, "partner":"4ik5" }, - { - "sim":316.0, - "partner":"3sg5" - }, - { - "sim":316.0, - "partner":"3sg7" - }, { "sim":316.0, "partner":"4ik8" @@ -491026,6 +493031,14 @@ "sim":316.0, "partner":"4ik4" }, + { + "sim":316.0, + "partner":"3sg5" + }, + { + "sim":316.0, + "partner":"3sg7" + }, { "sim":316.0, "partner":"3ek7" @@ -491072,15 +493085,15 @@ }, { "sim":311.0, - "partner":"6ya9" + "partner":"6zsm" }, { "sim":311.0, - "partner":"6zsm" + "partner":"6zsn" }, { "sim":311.0, - "partner":"6zsn" + "partner":"6ya9" }, { "sim":311.0, @@ -491164,11 +493177,11 @@ }, { "sim":179.0, - "partner":"4uad" + "partner":"7rht" }, { "sim":179.0, - "partner":"7rht" + "partner":"4uad" }, { "sim":177.0, @@ -491188,15 +493201,15 @@ }, { "sim":174.0, - "partner":"4b8p" + "partner":"2yns" }, { "sim":174.0, - "partner":"2yns" + "partner":"4b8o" }, { "sim":174.0, - "partner":"4b8o" + "partner":"4b8p" }, { "sim":174.0, @@ -491220,11 +493233,11 @@ }, { "sim":172.0, - "partner":"4pvz" + "partner":"1bk5" }, { "sim":172.0, - "partner":"1bk5" + "partner":"4pvz" }, { "sim":172.0, @@ -491284,11 +493297,11 @@ }, { "sim":168.0, - "partner":"4u5o" + "partner":"3ve6" }, { "sim":168.0, - "partner":"3ve6" + "partner":"6mjl" }, { "sim":168.0, @@ -491298,10 +493311,6 @@ "sim":168.0, "partner":"4u5s" }, - { - "sim":168.0, - "partner":"6mjl" - }, { "sim":168.0, "partner":"4u5u" @@ -491320,7 +493329,7 @@ }, { "sim":168.0, - "partner":"3l3q" + "partner":"4u5o" }, { "sim":168.0, @@ -491328,11 +493337,11 @@ }, { "sim":168.0, - "partner":"5hhg" + "partner":"3l3q" }, { "sim":168.0, - "partner":"3btr" + "partner":"5hhg" }, { "sim":168.0, @@ -491340,7 +493349,7 @@ }, { "sim":168.0, - "partner":"1y2a" + "partner":"3btr" }, { "sim":168.0, @@ -491366,6 +493375,10 @@ "sim":168.0, "partner":"7n9h" }, + { + "sim":168.0, + "partner":"1y2a" + }, { "sim":168.0, "partner":"6iw8" @@ -491386,10 +493399,6 @@ "sim":168.0, "partner":"1ial" }, - { - "sim":168.0, - "partner":"3zir" - }, { "sim":168.0, "partner":"2ynr" @@ -491410,6 +493419,10 @@ "sim":168.0, "partner":"3ziq" }, + { + "sim":168.0, + "partner":"3zir" + }, { "sim":167.0, "partner":"5xzx" @@ -491420,35 +493433,35 @@ }, { "sim":167.0, - "partner":"6bwa" + "partner":"7rfy" }, { "sim":167.0, - "partner":"6bvz" + "partner":"6wx8" }, { "sim":167.0, - "partner":"6bwb" + "partner":"7rg5" }, { "sim":167.0, - "partner":"7rfy" + "partner":"6bvv" }, { "sim":167.0, - "partner":"7rg5" + "partner":"6bw9" }, { "sim":167.0, - "partner":"6wx8" + "partner":"6bwa" }, { "sim":167.0, - "partner":"6bvv" + "partner":"6bvz" }, { "sim":167.0, - "partner":"6bw9" + "partner":"6bwb" }, { "sim":167.0, @@ -491460,11 +493473,11 @@ }, { "sim":167.0, - "partner":"7lf4" + "partner":"7lfc" }, { "sim":167.0, - "partner":"7lfc" + "partner":"7lf4" }, { "sim":166.0, @@ -491472,19 +493485,19 @@ }, { "sim":166.0, - "partner":"3q5u" + "partner":"5wun" }, { "sim":166.0, - "partner":"5wum" + "partner":"6p6a" }, { "sim":166.0, - "partner":"6wba" + "partner":"6wbb" }, { "sim":166.0, - "partner":"5wun" + "partner":"7m60" }, { "sim":166.0, @@ -491492,59 +493505,59 @@ }, { "sim":166.0, - "partner":"6p6a" + "partner":"6wbc" }, { "sim":166.0, - "partner":"6wbb" + "partner":"5x8n" }, { "sim":166.0, - "partner":"7m60" + "partner":"6p6e" }, { "sim":166.0, - "partner":"5x8n" + "partner":"4yi0" }, { "sim":166.0, - "partner":"6wbc" + "partner":"3knd" }, { "sim":166.0, - "partner":"6p6e" + "partner":"1ejl" }, { "sim":166.0, - "partner":"1ejl" + "partner":"1ejy" }, { "sim":166.0, - "partner":"4yi0" + "partner":"5b56" }, { "sim":166.0, - "partner":"3knd" + "partner":"1pjm" }, { "sim":166.0, - "partner":"1ejy" + "partner":"1iq1" }, { "sim":166.0, - "partner":"5b56" + "partner":"1pjn" }, { "sim":166.0, - "partner":"1iq1" + "partner":"3q5u" }, { "sim":166.0, - "partner":"1pjm" + "partner":"5wum" }, { "sim":166.0, - "partner":"1pjn" + "partner":"6wba" }, { "sim":166.0, @@ -491574,10 +493587,6 @@ "sim":166.0, "partner":"4ba3" }, - { - "sim":166.0, - "partner":"4htv" - }, { "sim":166.0, "partner":"5umz" @@ -491592,155 +493601,159 @@ }, { "sim":166.0, - "partner":"3rzx" + "partner":"4htv" }, { "sim":166.0, - "partner":"5e6q" + "partner":"5fc8" }, { "sim":166.0, - "partner":"3oqs" + "partner":"6bw1" }, { "sim":166.0, - "partner":"5w4f" + "partner":"5w4g" }, { "sim":166.0, - "partner":"6d7m" + "partner":"7rfz" }, { "sim":166.0, - "partner":"7rfx" + "partner":"7l04" }, { "sim":166.0, - "partner":"5fc8" + "partner":"3ukw" }, { "sim":166.0, - "partner":"6bw0" + "partner":"7rg0" }, { "sim":166.0, - "partner":"5w4g" + "partner":"3ukx" }, { "sim":166.0, - "partner":"6bw1" + "partner":"7rg1" }, { "sim":166.0, - "partner":"7rfz" + "partner":"7jvo" }, { "sim":166.0, - "partner":"3ukw" + "partner":"3uky" }, { "sim":166.0, - "partner":"7l04" + "partner":"5ekf" }, { "sim":166.0, - "partner":"7rg0" + "partner":"7rg2" }, { "sim":166.0, - "partner":"3ukx" + "partner":"3ukz" }, { "sim":166.0, - "partner":"7rg1" + "partner":"5u5p" }, { "sim":166.0, - "partner":"3uky" + "partner":"7rg3" }, { "sim":166.0, - "partner":"5ekf" + "partner":"5ekg" }, { "sim":166.0, - "partner":"7jvo" + "partner":"5svz" }, { "sim":166.0, - "partner":"7rg2" + "partner":"3ul0" }, { "sim":166.0, - "partner":"3ukz" + "partner":"6wx7" }, { "sim":166.0, - "partner":"5u5p" + "partner":"7rg4" }, { "sim":166.0, - "partner":"5ekg" + "partner":"3ul1" }, { "sim":166.0, - "partner":"5svz" + "partner":"3rz9" }, { "sim":166.0, - "partner":"7rg3" + "partner":"7rg6" }, { "sim":166.0, - "partner":"3ul0" + "partner":"5klr" }, { "sim":166.0, - "partner":"3ul1" + "partner":"6bvt" }, { "sim":166.0, - "partner":"7rg4" + "partner":"3uvu" }, { "sim":166.0, - "partner":"3rz9" + "partner":"5u5r" }, { "sim":166.0, - "partner":"6wx7" + "partner":"5w41" }, { "sim":166.0, - "partner":"7rg6" + "partner":"5klt" }, { "sim":166.0, - "partner":"5klr" + "partner":"5w4e" }, { "sim":166.0, - "partner":"3uvu" + "partner":"3rzx" }, { "sim":166.0, - "partner":"5u5r" + "partner":"5e6q" }, { "sim":166.0, - "partner":"6bvt" + "partner":"6d7m" }, { "sim":166.0, - "partner":"5w41" + "partner":"3oqs" }, { "sim":166.0, - "partner":"5klt" + "partner":"5w4f" }, { "sim":166.0, - "partner":"5w4e" + "partner":"6bw0" + }, + { + "sim":166.0, + "partner":"7rfx" }, { "sim":166.0, @@ -491808,11 +493821,11 @@ }, { "sim":134.0, - "partner":"6j1a" + "partner":"6jxf" }, { "sim":134.0, - "partner":"6jxf" + "partner":"6j1a" }, { "sim":131.0, @@ -491868,11 +493881,11 @@ }, { "sim":116.0, - "partner":"2i38" + "partner":"2i2y" }, { "sim":116.0, - "partner":"2i2y" + "partner":"2i38" }, { "sim":116.0, @@ -491914,18 +493927,6 @@ "sim":113.0, "partner":"7cxr" }, - { - "sim":112.0, - "partner":"2ju6" - }, - { - "sim":112.0, - "partner":"2kwd" - }, - { - "sim":112.0, - "partner":"6cte" - }, { "sim":112.0, "partner":"2k0p" @@ -491944,11 +493945,11 @@ }, { "sim":112.0, - "partner":"2lgi" + "partner":"6cne" }, { "sim":112.0, - "partner":"6cne" + "partner":"2lgi" }, { "sim":112.0, @@ -491972,15 +493973,19 @@ }, { "sim":112.0, - "partner":"6hka" + "partner":"2kwd" }, { - "sim":111.0, - "partner":"2klk" + "sim":112.0, + "partner":"6cte" }, { - "sim":111.0, - "partner":"1gb1" + "sim":112.0, + "partner":"2ju6" + }, + { + "sim":112.0, + "partner":"6hka" }, { "sim":111.0, @@ -491992,23 +493997,31 @@ }, { "sim":111.0, - "partner":"2rmm" + "partner":"1gb1" }, { "sim":111.0, "partner":"6cpz" }, + { + "sim":111.0, + "partner":"2rmm" + }, { "sim":111.0, "partner":"3gb1" }, + { + "sim":111.0, + "partner":"6che" + }, { "sim":111.0, "partner":"2gb1" }, { "sim":111.0, - "partner":"6che" + "partner":"2klk" }, { "sim":111.0, @@ -492280,7 +494293,7 @@ }, { "sim":102.0, - "partner":"2igh" + "partner":"6uyg" }, { "sim":102.0, @@ -492292,11 +494305,11 @@ }, { "sim":102.0, - "partner":"6uyg" + "partner":"2igd" }, { "sim":102.0, - "partner":"2igd" + "partner":"2igh" }, { "sim":102.0, @@ -492414,6 +494427,10 @@ "sim":99.0, "partner":"2zw1" }, + { + "sim":99.0, + "partner":"8ul1" + }, { "sim":99.0, "partner":"8ul2" @@ -492430,10 +494447,6 @@ "sim":99.0, "partner":"8ul5" }, - { - "sim":99.0, - "partner":"8ul1" - }, { "sim":99.0, "partner":"5fvf" @@ -492448,11 +494461,11 @@ }, { "sim":99.0, - "partner":"2vvi" + "partner":"2vvh" }, { "sim":99.0, - "partner":"2vvh" + "partner":"2vvi" }, { "sim":99.0, @@ -492584,15 +494597,15 @@ }, { "sim":96.0, - "partner":"7rrj" + "partner":"7rrh" }, { "sim":96.0, - "partner":"7rrh" + "partner":"7rri" }, { "sim":96.0, - "partner":"7rri" + "partner":"7rrj" }, { "sim":95.0, @@ -492668,15 +494681,15 @@ }, { "sim":93.0, - "partner":"4q9w" + "partner":"8ul0" }, { "sim":93.0, - "partner":"4q9x" + "partner":"4q9w" }, { "sim":93.0, - "partner":"8ul0" + "partner":"4q9x" }, { "sim":93.0, @@ -492752,11 +494765,11 @@ }, { "sim":91.0, - "partner":"3nf0" + "partner":"4h3n" }, { "sim":91.0, - "partner":"4h3n" + "partner":"3nf0" }, { "sim":91.0, @@ -492782,14 +494795,6 @@ "sim":90.0, "partner":"6ir2" }, - { - "sim":90.0, - "partner":"6nqn" - }, - { - "sim":90.0, - "partner":"6nqr" - }, { "sim":90.0, "partner":"6nqo" @@ -492818,6 +494823,14 @@ "sim":90.0, "partner":"6nqq" }, + { + "sim":90.0, + "partner":"6nqn" + }, + { + "sim":90.0, + "partner":"6nqr" + }, { "sim":90.0, "partner":"4i2y" @@ -492924,15 +494937,15 @@ }, { "sim":85.0, - "partner":"5hzt" + "partner":"5hzu" }, { "sim":85.0, - "partner":"5hzu" + "partner":"5hzs" }, { "sim":85.0, - "partner":"5hzs" + "partner":"5hzt" }, { "sim":85.0, @@ -493036,11 +495049,11 @@ }, { "sim":83.0, - "partner":"3mgf" + "partner":"6xwy" }, { "sim":83.0, - "partner":"6xwy" + "partner":"3mgf" }, { "sim":83.0, @@ -493140,11 +495153,11 @@ }, { "sim":79.0, - "partner":"5hhc" + "partner":"5hhd" }, { "sim":79.0, - "partner":"5hhd" + "partner":"5hhc" }, { "sim":79.0, @@ -493156,11 +495169,11 @@ }, { "sim":79.0, - "partner":"1mou" + "partner":"2p4m" }, { "sim":79.0, - "partner":"2p4m" + "partner":"1mou" }, { "sim":79.0, @@ -493224,11 +495237,11 @@ }, { "sim":77.0, - "partner":"1ggx" + "partner":"1zgo" }, { "sim":77.0, - "partner":"1zgo" + "partner":"1ggx" }, { "sim":77.0, @@ -493260,11 +495273,11 @@ }, { "sim":76.0, - "partner":"6mxw" + "partner":"1xss" }, { "sim":76.0, - "partner":"1xss" + "partner":"6mxw" }, { "sim":76.0, @@ -493318,10 +495331,6 @@ "sim":74.0, "partner":"2rh7" }, - { - "sim":74.0, - "partner":"3bxc" - }, { "sim":74.0, "partner":"3bx9" @@ -493334,6 +495343,10 @@ "sim":74.0, "partner":"3bxb" }, + { + "sim":74.0, + "partner":"3bxc" + }, { "sim":73.0, "partner":"4eds" @@ -493406,21 +495419,17 @@ "sim":70.0, "partner":"3pj7" }, - { - "sim":70.0, - "partner":"3h1o" - }, { "sim":70.0, "partner":"3h1r" }, { "sim":70.0, - "partner":"2ib6" + "partner":"3h1o" }, { "sim":70.0, - "partner":"4nws" + "partner":"2ib6" }, { "sim":70.0, @@ -493434,6 +495443,10 @@ "sim":70.0, "partner":"3u8c" }, + { + "sim":70.0, + "partner":"4nws" + }, { "sim":70.0, "partner":"5mwc" @@ -493554,10 +495567,6 @@ "sim":53.0, "partner":"7sf9" }, - { - "sim":52.0, - "partner":"2a53" - }, { "sim":52.0, "partner":"2a54" @@ -493578,17 +495587,21 @@ "sim":52.0, "partner":"2a52" }, + { + "sim":52.0, + "partner":"2a53" + }, { "sim":51.0, "partner":"3u0k" }, { "sim":50.0, - "partner":"2g6x" + "partner":"2g6y" }, { "sim":50.0, - "partner":"2g6y" + "partner":"2g6x" }, { "sim":50.0, @@ -493681,11 +495694,11 @@ ], "subtitle":"Ancestral protein ancthen of phosphomethylpyrimidine kinases family", "tags":[ + "transferase", + "ancestral protein reconstruction", "phosphomethylpyrimidine kinases family", - "enzyme evolution", "5-phosphohydroxymethyl-2-methylpyrimidine kinase", - "transferase", - "ancestral protein reconstruction" + "enzyme evolution" ], "keywords":[ "description", @@ -493766,10 +495779,6 @@ "sim":169.0, "partner":"3rm5" }, - { - "sim":167.0, - "partner":"4c5l" - }, { "sim":167.0, "partner":"4c5m" @@ -493786,6 +495795,10 @@ "sim":167.0, "partner":"4c5k" }, + { + "sim":167.0, + "partner":"4c5l" + }, { "sim":153.0, "partner":"4ywr" @@ -493820,15 +495833,15 @@ }, { "sim":62.0, - "partner":"6yjz" + "partner":"6yk0" }, { "sim":62.0, - "partner":"6yk0" + "partner":"6yk1" }, { "sim":62.0, - "partner":"6yk1" + "partner":"6yjz" }, { "sim":61.0, @@ -493852,43 +495865,43 @@ }, { "sim":59.0, - "partner":"2yxt" + "partner":"4eoh" }, { "sim":59.0, - "partner":"2yxu" + "partner":"3fhx" }, { "sim":59.0, - "partner":"4eoh" + "partner":"3keu" }, { "sim":59.0, - "partner":"3fhx" + "partner":"3fhy" }, { "sim":59.0, - "partner":"3keu" + "partner":"4en4" }, { "sim":59.0, - "partner":"3fhy" + "partner":"2yxt" }, { "sim":59.0, - "partner":"4en4" + "partner":"2yxu" }, { "sim":57.0, - "partner":"5zw9" + "partner":"5zwb" }, { "sim":57.0, - "partner":"5zwa" + "partner":"5zw9" }, { "sim":57.0, - "partner":"5zwb" + "partner":"5zwa" }, { "sim":57.0, @@ -494036,15 +496049,15 @@ }, { "sim":51.0, - "partner":"7e15" + "partner":"5ghr" }, { "sim":51.0, - "partner":"5ghr" + "partner":"5ghs" }, { "sim":51.0, - "partner":"5ghs" + "partner":"7e15" }, { "sim":51.0, @@ -494072,11 +496085,11 @@ }, { "sim":51.0, - "partner":"7ed6" + "partner":"7ed9" }, { "sim":51.0, - "partner":"7ed9" + "partner":"7ed6" }, { "sim":51.0, @@ -494120,23 +496133,23 @@ }, { "sim":51.0, - "partner":"2v8z" + "partner":"4ptn" }, { "sim":51.0, - "partner":"2v9d" + "partner":"4onv" }, { "sim":51.0, - "partner":"4ptn" + "partner":"4oe7" }, { "sim":51.0, - "partner":"4onv" + "partner":"2v9d" }, { "sim":51.0, - "partner":"4oe7" + "partner":"2v8z" }, { "sim":51.0, @@ -494174,14 +496187,6 @@ "sim":51.0, "partner":"2jlc" }, - { - "sim":51.0, - "partner":"4q4e" - }, - { - "sim":51.0, - "partner":"3b34" - }, { "sim":51.0, "partner":"3ked" @@ -494242,6 +496247,14 @@ "sim":51.0, "partner":"3qjx" }, + { + "sim":51.0, + "partner":"4q4e" + }, + { + "sim":51.0, + "partner":"3b34" + }, { "sim":50.0, "partner":"4hcn" @@ -494292,11 +496305,11 @@ }, { "sim":50.0, - "partner":"3zpc" + "partner":"3zpg" }, { "sim":50.0, - "partner":"3zpg" + "partner":"3zpc" }, { "sim":50.0, @@ -494409,11 +496422,11 @@ ], "subtitle":"Ancestral protein ancen of phosphomethylpyrimidine kinases family", "tags":[ + "transferase", + "ancestral protein reconstruction", "phosphomethylpyrimidine kinases family", - "enzyme evolution", "5-phosphohydroxymethyl-2-methylpyrimidine kinase", - "transferase", - "ancestral protein reconstruction" + "enzyme evolution" ], "keywords":[ "description", @@ -494494,10 +496507,6 @@ "sim":130.0, "partner":"3rm5" }, - { - "sim":119.0, - "partner":"4c5l" - }, { "sim":119.0, "partner":"4c5m" @@ -494514,6 +496523,10 @@ "sim":119.0, "partner":"4c5k" }, + { + "sim":119.0, + "partner":"4c5l" + }, { "sim":116.0, "partner":"4ywr" @@ -494528,15 +496541,15 @@ }, { "sim":55.0, - "partner":"3ibq" + "partner":"3hyo" }, { "sim":55.0, - "partner":"3hyo" + "partner":"3h74" }, { "sim":55.0, - "partner":"3h74" + "partner":"3ibq" }, { "sim":55.0, @@ -494592,15 +496605,15 @@ }, { "sim":52.0, - "partner":"7e15" + "partner":"5ghr" }, { "sim":52.0, - "partner":"5ghr" + "partner":"5ghs" }, { "sim":52.0, - "partner":"5ghs" + "partner":"7e15" }, { "sim":52.0, @@ -494700,11 +496713,11 @@ }, { "sim":51.0, - "partner":"7ed6" + "partner":"7ed9" }, { "sim":51.0, - "partner":"7ed9" + "partner":"7ed6" }, { "sim":51.0, @@ -494764,11 +496777,11 @@ }, { "sim":51.0, - "partner":"3zpc" + "partner":"3zpg" }, { "sim":51.0, - "partner":"3zpg" + "partner":"3zpc" }, { "sim":51.0, @@ -494800,11 +496813,11 @@ }, { "sim":51.0, - "partner":"4b31" + "partner":"4aul" }, { "sim":51.0, - "partner":"4aul" + "partner":"4b31" }, { "sim":51.0, @@ -494834,14 +496847,6 @@ "sim":51.0, "partner":"4b2y" }, - { - "sim":51.0, - "partner":"4q4e" - }, - { - "sim":51.0, - "partner":"3b34" - }, { "sim":51.0, "partner":"3ked" @@ -494902,6 +496907,14 @@ "sim":51.0, "partner":"3qjx" }, + { + "sim":51.0, + "partner":"4q4e" + }, + { + "sim":51.0, + "partner":"3b34" + }, { "sim":50.0, "partner":"2grg" @@ -494920,15 +496933,15 @@ }, { "sim":50.0, - "partner":"3lvy" + "partner":"2i6h" }, { "sim":50.0, - "partner":"2i6h" + "partner":"2evv" }, { "sim":50.0, - "partner":"2evv" + "partner":"3lvy" }, { "sim":50.0, @@ -495065,88 +497078,88 @@ ], "subtitle":"Circular tandem repeat protein with novel repeat topology and enhanced subunit contact surfaces", "tags":[ - "protein display particles", - "peptide binding protein" + "peptide binding protein", + "protein display particles" ], "keywords":[ - "domain", - "constructs", - "studies", - "sh2", - "potent", - "scaffolds", - "designed", - "receptor", - "towards", - "smaller", - "particles", - "hexameric", - "based", - "sequences", - "enhanced", - "vhh", - "display", - "repeat", - "however", - "latter", - "biotechnology", - "interaction", - "array", - "longer", - "proteins", - "viral", - "de", - "inefficient", + "repeats", "finally", - "ctrps", - "trimeric", - "structures", "proved", - "function", + "structural", + "repeat", + "solubility", + "new", + "particles", + "protein", + "study", + "increased", + "significantly", + "binding", + "novo", + "demonstrate", + "domains", "circular", "motifs", - "significantly", - "form", - "functionalization", - "repeated", - "stability", - "neutralization", - "generation", - "demonstrated", + "two", + "applications", + "prior", + "receptor", + "antiparallel", "bundles", - "increased", - "1", - "tandem", + "however", + "closed", + "sh2", + "functionalization", "surfaces", "useful", - "applications", - "describe", - "repeats", + "stability", + "proteins", + "capable", + "2", + "tandem", + "neutralization", + "contain", + "ctrps", "subunits", - "structural", - "range", - "solubility", - "demonstrate", - "closed", - "prior", + "longer", + "1", + "hexameric", + "enhanced", + "display", + "different", + "domain", + "sizes", "also", - "study", - "novo", "wide", - "sizes", - "different", - "capable", - "affinities", - "two", - "antiparallel", + "interaction", + "viral", + "demonstrated", + "repeated", + "range", + "describe", + "designed", + "form", + "trimeric", + "generation", + "sequences", + "array", + "latter", + "structures", + "de", + "constructs", + "based", + "vhh", + "scaffolds", "homotrimeric", - "domains", - "significant", - "protein", - "2", - "binding", - "contain", - "new" + "function", + "inefficient", + "towards", + "smaller", + "studies", + "potent", + "affinities", + "biotechnology", + "significant" ], "release_date":"2021-09-01", "publication":"\"Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces\", Commun Biol, 4, 1240-1240", @@ -495273,89 +497286,89 @@ ], "subtitle":"Computationally designed tunable c2 symmetric tandem repeat homodimer, d_3_633", "tags":[ - "torroid", - "computationally designed", "homodimer", - "derroid", + "de novo", + "de novo protein", + "torroid", "tandem repeat", "c2 symmetric", - "de novo protein", - "de novo" + "derroid", + "computationally designed" ], "keywords":[ - "diverse", - "sample", - "general", - "make", - "angle", - "advantageous", - "follows", - "ligand", - "31", - "proteins", - "analyses", - "rise", + "designed", + "form", + "designing", "models", - "approach", - "low", - "generate", - "thousands", - "geometry", - "scattering", - "close", - "wide", + "symmetry", + "design", "characterized", - "scaffolds", - "shape", - "designed", - "confirmed", - "small", - "requires", + "cavities", + "101", + "continuum", + "hyperstable", + "follows", + "geometry", + "repeat", + "diverse", "used", - "subunit", + "starting", + "biology", + "thousands", "agreement", - "shown", - "provide", - "symmetric", + "wide", + "first", "experimentally", - "set", + "ligand", + "subunit", "points", - "match", - "design", - "crystallographic", - "helical", - "101", - "protein", + "rich", + "scaffolds", + "shape", + "ligands", + "generate", + "make", + "provide", "interactions", + "protein", + "curvatures", + "31", + "function", + "pockets", + "approach", + "shown", "homodimers", + "proteins", + "helical", + "binding", + "symmetric", + "low", + "molecules", + "size", + "close", + "scattering", + "matching", + "extensive", + "confirmed", + "general", "2", + "compounds", + "requires", + "match", + "small", + "angle", + "sample", "identical", - "pockets", - "designing", - "symmetry", - "describe", - "continuum", - "function", - "matching", - "repeat", "docked", - "cavities", - "biology", - "hyperstable", - "size", - "compounds", - "ligands", - "computational", - "rich", - "form", + "describe", + "range", + "analyses", + "crystallographic", "c2", - "extensive", - "first", - "molecules", - "curvatures", - "binding", - "starting", - "range" + "computational", + "advantageous", + "rise", + "set" ], "release_date":"2022-05-18", "publication":"\"De novo design of protein homodimers containing tunable symmetric protein pockets\", Proc.Natl.Acad.Sci.USA, 119, e2113400119-e2113400119", @@ -495524,86 +497537,86 @@ ], "subtitle":"Structure of de novo designed tunable symmetric protein pockets", "tags":[ - "symmetric protein", - "tunable", - "de novo protein", "pockets", - "de novo design" + "de novo design", + "de novo protein", + "symmetric protein", + "tunable" ], "keywords":[ - "diverse", - "sample", - "general", - "make", - "angle", - "advantageous", - "follows", - "ligand", - "31", - "proteins", - "analyses", - "rise", + "designed", + "form", + "designing", "models", - "approach", - "low", - "generate", - "thousands", - "geometry", - "scattering", - "close", - "wide", + "symmetry", + "design", "characterized", - "scaffolds", - "shape", - "designed", - "confirmed", - "small", - "requires", + "cavities", + "101", + "continuum", + "hyperstable", + "follows", + "geometry", + "repeat", + "diverse", "used", - "subunit", + "starting", + "biology", + "thousands", "agreement", - "shown", - "provide", - "symmetric", + "wide", + "first", "experimentally", - "set", + "ligand", + "subunit", "points", - "match", - "design", - "crystallographic", - "helical", - "101", - "protein", + "rich", + "scaffolds", + "shape", + "ligands", + "generate", + "make", + "provide", "interactions", + "protein", + "curvatures", + "31", + "function", + "pockets", + "approach", + "shown", "homodimers", + "proteins", + "helical", + "binding", + "symmetric", + "low", + "molecules", + "size", + "close", + "scattering", + "matching", + "extensive", + "confirmed", + "general", "2", + "compounds", + "requires", + "match", + "small", + "angle", + "sample", "identical", - "pockets", - "designing", - "symmetry", - "describe", - "continuum", - "function", - "matching", - "repeat", "docked", - "cavities", - "biology", - "hyperstable", - "size", - "compounds", - "ligands", - "computational", - "rich", - "form", + "describe", + "range", + "analyses", + "crystallographic", "c2", - "extensive", - "first", - "molecules", - "curvatures", - "binding", - "starting", - "range" + "computational", + "advantageous", + "rise", + "set" ], "release_date":"2022-08-03", "publication":"\"De novo design of protein homodimers containing tunable symmetric protein pockets\", Proc.Natl.Acad.Sci.USA, 119, e2113400119-e2113400119", @@ -495642,6 +497655,10 @@ "sim":84.0, "partner":"8e1e" }, + { + "sim":74.0, + "partner":"8vea" + }, { "sim":62.0, "partner":"7rkc" @@ -495656,11 +497673,11 @@ }, { "sim":57.0, - "partner":"7udm" + "partner":"7udn" }, { "sim":57.0, - "partner":"7udn" + "partner":"7udm" }, { "sim":56.0, @@ -495769,85 +497786,85 @@ "subtitle":"De novo designed tunable protein pockets, d_3-337", "tags":[ "homodimer", - "de novo protein", - "repeat protein", "tunable pocket", - "de novo design" + "de novo design", + "de novo protein", + "repeat protein" ], "keywords":[ - "diverse", - "sample", - "general", - "make", - "angle", - "advantageous", - "follows", - "ligand", - "31", - "proteins", - "analyses", - "rise", + "designed", + "form", + "designing", "models", - "approach", - "low", - "generate", - "thousands", - "geometry", - "scattering", - "close", - "wide", + "symmetry", + "design", "characterized", - "scaffolds", - "shape", - "designed", - "confirmed", - "small", - "requires", + "cavities", + "101", + "continuum", + "hyperstable", + "follows", + "geometry", + "repeat", + "diverse", "used", - "subunit", + "starting", + "biology", + "thousands", "agreement", - "shown", - "provide", - "symmetric", + "wide", + "first", "experimentally", - "set", + "ligand", + "subunit", "points", - "match", - "design", - "crystallographic", - "helical", - "101", - "protein", + "rich", + "scaffolds", + "shape", + "ligands", + "generate", + "make", + "provide", "interactions", + "protein", + "curvatures", + "31", + "function", + "pockets", + "approach", + "shown", "homodimers", + "proteins", + "helical", + "binding", + "symmetric", + "low", + "molecules", + "size", + "close", + "scattering", + "matching", + "extensive", + "confirmed", + "general", "2", + "compounds", + "requires", + "match", + "small", + "angle", + "sample", "identical", - "pockets", - "designing", - "symmetry", - "describe", - "continuum", - "function", - "matching", - "repeat", "docked", - "cavities", - "biology", - "hyperstable", - "size", - "compounds", - "ligands", - "computational", - "rich", - "form", + "describe", + "range", + "analyses", + "crystallographic", "c2", - "extensive", - "first", - "molecules", - "curvatures", - "binding", - "starting", - "range" + "computational", + "advantageous", + "rise", + "set" ], "release_date":"2022-08-03", "publication":"\"De novo design of protein homodimers containing tunable symmetric protein pockets\", Proc.Natl.Acad.Sci.USA, 119, e2113400119-e2113400119", @@ -495904,11 +497921,15 @@ }, { "sim":67.0, - "partner":"7udm" + "partner":"7udn" }, { "sim":67.0, - "partner":"7udn" + "partner":"7udm" + }, + { + "sim":57.0, + "partner":"8vea" }, { "sim":54.0, @@ -495996,82 +498017,82 @@ "subtitle":"Cryo-em reconstruction of form1-n2 nanotube (form i like)", "tags":[ "de novo protein", - "helical symmetry", "self-assembly", - "peptide nanotube" + "peptide nanotube", + "helical symmetry" ], "keywords":[ - "structural", - "analysis", - "nevertheless", - "demonstrated", - "viruses", - "noncovalent", + "choice", + "relatively", "chemistry", - "long", - "soft", - "familiarity", - "solved", + "analysis", + "behavior", + "limited", + "mainly", + "revealed", + "structural", "filaments", - "developed", - "use", - "assemblies", - "lack", - "also", - "study", - "scattering", "resolution", - "contrast", - "peptide", - "eukaryotes", - "method", "number", - "electron", - "something", - "may", "spectroscopy", - "mainly", - "choice", - "enormous", - "science", - "communities", + "able", + "archaea", + "structures", + "chaotic", + "biology", "due", - "matter", - "materials", - "huge", "fact", - "currently", - "behavior", - "limited", - "bacteria", + "matter", + "macromolecular", + "biological", + "potential", "application", - "polymers", + "cryogenic", + "communities", + "synthetic", + "obscured", "addition", - "potential", + "structure", + "something", + "nanotubes", + "also", + "viruses", + "soft", + "eukaryotes", + "technique", + "study", "polymorphism", - "far", + "electron", "helical", - "structures", - "synthetic", "microscopy", - "macromolecular", - "technique", - "archaea", - "structure", - "relatively", - "chaotic", - "revealed", - "biology", - "biological", - "techniques", - "predict", - "obscured", - "able", + "use", + "enormous", + "familiarity", + "contrast", + "noncovalent", "ribbons", "much", - "cryogenic", + "may", + "scattering", + "far", + "demonstrated", + "solved", + "predict", "history", - "nanotubes" + "developed", + "polymers", + "techniques", + "currently", + "nevertheless", + "assemblies", + "materials", + "long", + "method", + "bacteria", + "peptide", + "huge", + "lack", + "science" ], "release_date":"2021-09-08", "publication":"\"Cryo-EM of Helical Polymers\", Chem.Rev., 122, 14055-14065", @@ -496308,102 +498329,102 @@ "minibinder protein inhibitor cytokine receptor interleukin-7" ], "keywords":[ + "hyperstable", + "half", + "experimental", "complexes", - "modes", - "challenge", - "search", - "broad", - "shapes", - "provide", - "current", - "smaller", - "crystal", - "target", - "applicability", - "bind", - "interactions", - "structure", - "therapeutic", - "general", - "proteins", - "models", - "enables", - "hundreds", - "thousands", - "de", - "point", - "remains", - "targeted", - "binders", + "information", + "intensifies", + "million", + "protein", + "binding", + "following", "site", - "picomolar", + "general", + "novo", + "demonstrate", "match", - "feedback", - "nanomolar", - "structures", - "improvements", - "solution", + "vast", + "variety", + "succeeded", + "applications", + "region", + "crystal", "corresponding", - "65", - "mutants", + "using", + "enables", "shows", "nearly", - "properties", - "data", - "following", - "amino", - "guide", - "detailed", - "exploration", - "optimization", - "acids", - "information", - "method", - "limitations", "interest", - "closely", - "region", + "modes", + "selected", "specific", - "12", - "design", + "targets", + "vicinity", + "optimization", + "bind", + "approach", + "proteins", + "sites", + "mutants", "characterization", - "using", - "applications", + "broad", + "improvements", + "shapes", + "nanomolar", + "computational", + "applicability", "surface", - "describe", - "promising", - "selected", - "sites", + "12", + "design", "diverse", - "demonstrate", - "designs", - "approach", - "novo", - "wide", - "succeeded", - "experimental", - "half", - "vicinity", + "binders", + "65", + "current", + "thousands", + "possible", "different", - "intensifies", - "strengths", - "affinities", - "problem", - "protein", - "targets", - "vast", + "properties", + "therapeutic", + "point", + "amino", + "wide", + "solution", + "promising", + "hundreds", + "describe", + "method", + "search", + "models", "space", - "variety", + "strengths", + "targeted", + "structures", + "de", + "feedback", "solving", - "hyperstable", - "understanding", - "computational", - "diagnostic", - "million", + "detailed", + "remains", + "structure", + "provide", + "closely", + "target", "starts", - "possible", - "binding", + "exploration", "biophysical", + "interactions", + "understanding", + "smaller", + "guide", + "acids", + "picomolar", + "diagnostic", + "data", + "problem", + "limitations", + "challenge", + "affinities", + "designs", "five" ], "release_date":"2022-05-11", @@ -496916,11 +498937,11 @@ }, { "sim":51.0, - "partner":"7skn" + "partner":"7sko" }, { "sim":51.0, - "partner":"7sko" + "partner":"7skn" } ], "seq_thr_sim_natural":[ @@ -497010,67 +499031,67 @@ "tim-barrel" ], "keywords":[ - "priors", - "without", - "data", - "demonstrate", - "produces", - "designs", - "excellent", - "directly", - "network", - "guide", - "models", - "entirely", - "generalizability", - "training", - "evaluate", - "stable", - "de", - "rational", - "novo", - "topologies", - "problems", - "method", - "tractability", - "seen", - "enormous", - "functions", - "agreement", + "learned", + "task", + "central", "producing", - "two", - "experimentally", - "crystal", "engineering", - "central", - "effort", - "scaffold", - "show", + "models", "design", - "task", - "model", "sequences", + "problems", + "energy", + "capability", "onto", - "gone", + "development", + "backbones", + "show", + "nearly", "structures", - "protein", + "de", + "effort", + "rational", + "agreement", + "training", + "experimentally", + "without", + "structure", + "novel", + "gone", + "generalizability", + "functions", + "model", + "seen", "findings", - "development", + "protein", + "network", + "topologies", + "automate", "neural", - "learned", - "sequence", - "structure", + "produces", + "silico", + "enormous", + "evaluate", + "priors", + "entirely", + "novo", + "demonstrate", "native", - "energy", + "scaffold", + "sequence", + "guide", "generalizes", - "automate", - "silico", - "nearly", + "excellent", + "two", + "data", + "crystal", + "stable", + "tractability", + "designs", + "method", + "investigate", "deep", - "backbones", - "novel", - "capability", - "investigate" + "directly" ], "release_date":"2022-03-16", "publication":"\"Protein sequence design with a learned potential\", Nat Commun, 13, 746-746", @@ -497127,11 +499148,11 @@ }, { "sim":136.0, - "partner":"7ot7" + "partner":"7osu" }, { "sim":136.0, - "partner":"7osu" + "partner":"7ot7" }, { "sim":136.0, @@ -497255,95 +499276,95 @@ "subtitle":"Designed trefoil knot protein, variant 1", "tags":[ "tandem repeat protein", + "de novo protein", "trefoil", "knot", - "trp", - "de novo protein" + "trp" ], "keywords":[ - "compatibility", + "repeats", "largely", + "ray", + "whose", + "insights", + "interesting", + "repeat", + "methods", + "knotted", + "extended", "results", - "thus", - "misfolded", - "crystallography", + "folding", + "protein", + "topologies", + "5", + "focus", + "x", + "confirmed", + "novo", "test", - "designed", - "provide", - "local", - "pathways", - "methods", - "order", - "sequences", + "two", + "misfolded", + "asymmetric", "conformation", - "represent", - "structure", - "repeat", - "insights", - "intended", "backbones", + "algorithms", + "thus", + "pentafoil", + "matched", + "intended", + "case", "contacts", - "without", - "5", - "topology", + "stability", "proteins", - "de", - "focus", - "knotted", - "seen", - "yet", - "consideration", - "nature", - "symmetric", - "3", - "pentafoil", + "described", + "tandem", + "may", "units", - "whose", - "attempts", + "compatibility", + "diverged", "construct", - "matching", - "trefoil", - "form", - "previously", - "stability", - "substantial", - "report", - "extended", - "asymmetric", "four", - "topologies", + "pathways", + "substantial", "1", - "may", - "tandem", - "interesting", - "diverged", + "local", "design", - "rather", - "introduce", - "explicit", - "sequence", - "repeats", - "ray", - "optimizing", - "despite", - "also", - "n", - "described", - "novo", + "topology", + "represent", + "yet", "behaviour", - "matched", - "confirmed", - "two", - "folds", - "barriers", + "n", + "also", + "seen", + "consideration", + "symmetric", "leading", - "protein", + "matching", "backbone", - "algorithms", + "sequence", + "folds", + "explicit", "deeply", - "x", - "case", - "folding", + "designed", + "form", + "order", + "sequences", + "rather", + "trefoil", + "de", + "3", + "attempts", + "previously", + "without", + "optimizing", + "structure", + "introduce", + "report", + "provide", + "crystallography", + "nature", + "barriers", + "despite", "create" ], "release_date":"2022-06-29", @@ -497473,95 +499494,95 @@ "subtitle":"Designed trefoil knot protein, variant 2", "tags":[ "tandem repeat protein", + "de novo protein", "trefoil", "knot", - "trp", - "de novo protein" + "trp" ], "keywords":[ - "compatibility", + "repeats", "largely", + "ray", + "whose", + "insights", + "interesting", + "repeat", + "methods", + "knotted", + "extended", "results", - "thus", - "misfolded", - "crystallography", + "folding", + "protein", + "topologies", + "5", + "focus", + "x", + "confirmed", + "novo", "test", - "designed", - "provide", - "local", - "pathways", - "methods", - "order", - "sequences", + "two", + "misfolded", + "asymmetric", "conformation", - "represent", - "structure", - "repeat", - "insights", - "intended", "backbones", + "algorithms", + "thus", + "pentafoil", + "matched", + "intended", + "case", "contacts", - "without", - "5", - "topology", + "stability", "proteins", - "de", - "focus", - "knotted", - "seen", - "yet", - "consideration", - "nature", - "symmetric", - "3", - "pentafoil", + "described", + "tandem", + "may", "units", - "whose", - "attempts", + "compatibility", + "diverged", "construct", - "matching", - "trefoil", - "form", - "previously", - "stability", - "substantial", - "report", - "extended", - "asymmetric", "four", - "topologies", + "pathways", + "substantial", "1", - "may", - "tandem", - "interesting", - "diverged", + "local", "design", - "rather", - "introduce", - "explicit", - "sequence", - "repeats", - "ray", - "optimizing", - "despite", - "also", - "n", - "described", - "novo", + "topology", + "represent", + "yet", "behaviour", - "matched", - "confirmed", - "two", - "folds", - "barriers", + "n", + "also", + "seen", + "consideration", + "symmetric", "leading", - "protein", + "matching", "backbone", - "algorithms", + "sequence", + "folds", + "explicit", "deeply", - "x", - "case", - "folding", + "designed", + "form", + "order", + "sequences", + "rather", + "trefoil", + "de", + "3", + "attempts", + "previously", + "without", + "optimizing", + "structure", + "introduce", + "report", + "provide", + "crystallography", + "nature", + "barriers", + "despite", "create" ], "release_date":"2022-06-29", @@ -497698,95 +499719,95 @@ "subtitle":"Designed trefoil knot protein, variant 3", "tags":[ "tandem repeat protein", + "de novo protein", "trefoil", "knot", - "trp", - "de novo protein" + "trp" ], "keywords":[ - "compatibility", + "repeats", "largely", + "ray", + "whose", + "insights", + "interesting", + "repeat", + "methods", + "knotted", + "extended", "results", - "thus", - "misfolded", - "crystallography", + "folding", + "protein", + "topologies", + "5", + "focus", + "x", + "confirmed", + "novo", "test", - "designed", - "provide", - "local", - "pathways", - "methods", - "order", - "sequences", + "two", + "misfolded", + "asymmetric", "conformation", - "represent", - "structure", - "repeat", - "insights", - "intended", "backbones", + "algorithms", + "thus", + "pentafoil", + "matched", + "intended", + "case", "contacts", - "without", - "5", - "topology", + "stability", "proteins", - "de", - "focus", - "knotted", - "seen", - "yet", - "consideration", - "nature", - "symmetric", - "3", - "pentafoil", + "described", + "tandem", + "may", "units", - "whose", - "attempts", + "compatibility", + "diverged", "construct", - "matching", - "trefoil", - "form", - "previously", - "stability", - "substantial", - "report", - "extended", - "asymmetric", "four", - "topologies", + "pathways", + "substantial", "1", - "may", - "tandem", - "interesting", - "diverged", + "local", "design", - "rather", - "introduce", - "explicit", - "sequence", - "repeats", - "ray", - "optimizing", - "despite", - "also", - "n", - "described", - "novo", + "topology", + "represent", + "yet", "behaviour", - "matched", - "confirmed", - "two", - "folds", - "barriers", + "n", + "also", + "seen", + "consideration", + "symmetric", "leading", - "protein", + "matching", "backbone", - "algorithms", + "sequence", + "folds", + "explicit", "deeply", - "x", - "case", - "folding", + "designed", + "form", + "order", + "sequences", + "rather", + "trefoil", + "de", + "3", + "attempts", + "previously", + "without", + "optimizing", + "structure", + "introduce", + "report", + "provide", + "crystallography", + "nature", + "barriers", + "despite", "create" ], "release_date":"2022-11-09", @@ -497935,108 +499956,108 @@ ], "keywords":[ "largely", - "unfolding", - "results", - "suggest", - "featuring", - "test", + "hydrophobic", + "structural", + "additional", + "number", + "tuned", + "well", + "core", "roles", - "designed", - "retained", - "features", - "ii", - "order", - "interactions", - "structure", - "intrusion", - "networks", - "hydrophilic", - "crucial", - "relates", + "featuring", + "results", + "folding", + "protein", "network", - "play", - "similar", - "random", - "de", - "sciences", - "spaces", + "study", + "helical", + "across", + "unfolding", + "thermodynamic", + "extensive", + "networks", + "novo", "manner", - "number", - "onset", - "seen", - "resulting", - "highly", - "landscapes", - "furthermore", - "content", - "dynamics", + "test", + "two", + "related", + "heat", + "similar", + "water", + "play", + "complex", + "conformational", "dynamic", - "versus", - "transitions", - "function", "thermodynamically", - "coil", - "heat", - "extensive", - "additional", - "hardly", - "hydrogen", - "created", - "associated", "dcub1", - "resulted", - "thermodynamic", - "landscape", - "dimer", "decoupled", - "bundle", - "design", - "core", + "dimer", + "furthermore", + "relative", + "helix", + "crucial", + "hydrophilic", "characterization", - "helical", - "cooperative", + "hydrogen", + "highly", + "suggest", + "created", "bond", + "compact", + "features", + "hardly", "initiated", - "explored", - "states", - "hydrophobic", - "across", - "bipartite", + "bundle", + "importance", + "theories", + "robustly", + "design", "energy", + "transitions", + "content", + "seen", + "explore", + "explored", + "extends", + "resulted", "formation", - "known", - "structural", - "important", + "varying", + "retained", + "states", + "landscape", + "unfolded", + "versus", + "associated", + "landscapes", "invaluable", - "compact", - "importance", - "robustly", - "disintegrates", - "conformational", - "study", - "novo", - "theories", + "cooperative", + "dynamics", + "sciences", "cooperativity", - "discovery", - "well", - "unfolded", - "proven", - "two", + "designed", + "order", + "relates", + "intrusion", + "de", + "onset", + "structure", + "important", + "resulting", + "interactions", "state", - "tuned", - "explore", - "protein", - "complex", - "helix", - "water", - "varying", + "spaces", + "function", "understanding", - "extends", + "known", + "disintegrates", + "random", + "bipartite", "cold", - "folding", - "relative", "internal", - "related" + "coil", + "proven", + "discovery", + "ii" ], "release_date":"2022-03-02", "publication":"\"From Protein Design to the Energy Landscape of a Cold Unfolding Protein\", J.Phys.Chem.B, 126, 1212-1231", @@ -498079,11 +500100,11 @@ "seq_thr_sim_natural":[ { "sim":171.0, - "partner":"2lch" + "partner":"3u3b" }, { "sim":171.0, - "partner":"3u3b" + "partner":"2lch" }, { "sim":120.0, @@ -498106,7 +500127,7 @@ }, "seq_max_sim_natural":{ "sim":171.0, - "partner":"2lch" + "partner":"3u3b" }, "struct_max_sim_designed":{ "sim":0.8561999798, @@ -498196,115 +500217,115 @@ ], "subtitle":"X-ray structure of a designed cold unfolding four helix bundle", "tags":[ + "alpha helix", "de novo protein", "cold denaturation", - "alpha helix", "hydrophobic core" ], "keywords":[ "largely", - "unfolding", - "results", - "suggest", - "featuring", - "test", + "hydrophobic", + "structural", + "additional", + "number", + "tuned", + "well", + "core", "roles", - "designed", - "retained", - "features", - "ii", - "order", - "interactions", - "structure", - "intrusion", - "networks", - "hydrophilic", - "crucial", - "relates", + "featuring", + "results", + "folding", + "protein", "network", - "play", - "similar", - "random", - "de", - "sciences", - "spaces", + "study", + "helical", + "across", + "unfolding", + "thermodynamic", + "extensive", + "networks", + "novo", "manner", - "number", - "onset", - "seen", - "resulting", - "highly", - "landscapes", - "furthermore", - "content", - "dynamics", + "test", + "two", + "related", + "heat", + "similar", + "water", + "play", + "complex", + "conformational", "dynamic", - "versus", - "transitions", - "function", "thermodynamically", - "coil", - "heat", - "extensive", - "additional", - "hardly", - "hydrogen", - "created", - "associated", "dcub1", - "resulted", - "thermodynamic", - "landscape", - "dimer", "decoupled", - "bundle", - "design", - "core", + "dimer", + "furthermore", + "relative", + "helix", + "crucial", + "hydrophilic", "characterization", - "helical", - "cooperative", + "hydrogen", + "highly", + "suggest", + "created", "bond", + "compact", + "features", + "hardly", "initiated", - "explored", - "states", - "hydrophobic", - "across", - "bipartite", + "bundle", + "importance", + "theories", + "robustly", + "design", "energy", + "transitions", + "content", + "seen", + "explore", + "explored", + "extends", + "resulted", "formation", - "known", - "structural", - "important", + "varying", + "retained", + "states", + "landscape", + "unfolded", + "versus", + "associated", + "landscapes", "invaluable", - "compact", - "importance", - "robustly", - "disintegrates", - "conformational", - "study", - "novo", - "theories", + "cooperative", + "dynamics", + "sciences", "cooperativity", - "discovery", - "well", - "unfolded", - "proven", - "two", + "designed", + "order", + "relates", + "intrusion", + "de", + "onset", + "structure", + "important", + "resulting", + "interactions", "state", - "tuned", - "explore", - "protein", - "complex", - "helix", - "water", - "varying", + "spaces", + "function", "understanding", - "extends", + "known", + "disintegrates", + "random", + "bipartite", "cold", - "folding", - "relative", "internal", - "related" + "coil", + "proven", + "discovery", + "ii" ], "release_date":"2022-03-02", "publication":"\"From Protein Design to the Energy Landscape of a Cold Unfolding Protein\", J.Phys.Chem.B, 126, 1212-1231", @@ -498347,11 +500368,11 @@ "seq_thr_sim_natural":[ { "sim":171.0, - "partner":"2lch" + "partner":"3u3b" }, { "sim":171.0, - "partner":"3u3b" + "partner":"2lch" }, { "sim":120.0, @@ -498374,7 +500395,7 @@ }, "seq_max_sim_natural":{ "sim":171.0, - "partner":"2lch" + "partner":"3u3b" }, "struct_max_sim_designed":{ "sim":0.8748999834, @@ -498444,89 +500465,89 @@ ], "subtitle":"Cryo-em of nbd-ffsy filaments (class 1)", "tags":[ + "peptides", + "hydrogel", + "self-assembly peptide filament", + "protein fibril", "transcytosis", "spheroids", - "self-assembly peptide filament", - "hydrogel", - "peptides", - "nanofibers", - "protein fibril" + "nanofibers" ], "keywords":[ - "transcytosis", - "without", - "poorly", - "nanofibres", - "gels", - "animal", + "protease", "induce", - "tissue", - "bridge", - "facilitate", - "models", + "form", + "surface", "undergo", - "cell", - "inducing", - "use", + "models", + "engineering", + "poorly", + "however", + "vivo", + "atomic", + "show", + "switching", + "phosphate", + "resistant", + "fibronectins", + "triggers", + "artificial", + "medicine", "imaging", - "process", + "intercellular", + "secretion", + "remains", + "potential", "specifically", - "generate", - "assemblies", - "approach", + "cryogenic", + "structure", + "without", + "fluorescent", + "shape", + "bridge", + "gels", + "occurs", + "transformation", + "fibrillogenesis", "fibronectin", - "act", - "medicine", - "artificial", + "cell", + "exocytosis", "inefficient", - "peptide", - "shape", - "enable", - "electron", - "morphological", - "remains", - "determine", - "spheroid", - "protease", - "understood", - "phosphate", - "potentially", - "endocytosis", - "switching", + "endosomal", + "approach", "interact", - "matrices", - "fibronectins", + "electron", "vitro", - "induces", - "transformation", - "potential", - "engineering", - "show", "helical", - "secretion", + "process", + "nanofibres", + "animal", + "formation", + "endocytosis", + "understood", "microscopy", - "exocytosis", - "surface", - "atomic", "nanomaterials", - "structure", - "resistant", - "dephosphorylation", - "spheroids", - "fibrillogenesis", - "vivo", - "intercellular", - "endosomal", - "formation", - "form", - "triggers", - "however", + "use", + "enable", + "act", + "spheroid", + "matrices", + "morphological", "regenerative", "systems", - "occurs", - "cryogenic", + "dephosphorylation", + "potentially", + "tissue", "discontinuity", - "fluorescent" + "determine", + "assemblies", + "inducing", + "spheroids", + "facilitate", + "generate", + "peptide", + "induces", + "transcytosis" ], "release_date":"2023-01-25", "publication":"\"Cell spheroid creation by transcytotic intercellular gelation\", Nat Nanotechnol, 18, 1094-1104", @@ -498612,8 +500633,8 @@ ], "subtitle":"Lov2-darpin fusion : d4_deltadarp", "tags":[ - "light switching", - "de novo protein" + "de novo protein", + "light switching" ], "keywords":[ "description", @@ -498680,15 +500701,15 @@ }, { "sim":275.0, - "partner":"5dju" + "partner":"5efw" }, { "sim":275.0, - "partner":"5efw" + "partner":"5djt" }, { "sim":275.0, - "partner":"5djt" + "partner":"5dju" }, { "sim":275.0, @@ -498710,10 +500731,6 @@ "sim":274.0, "partner":"2v1b" }, - { - "sim":274.0, - "partner":"2v0u" - }, { "sim":274.0, "partner":"2v0w" @@ -498726,6 +500743,10 @@ "sim":274.0, "partner":"7pgy" }, + { + "sim":274.0, + "partner":"2v0u" + }, { "sim":274.0, "partner":"2wkr" @@ -498792,43 +500813,43 @@ }, { "sim":200.0, - "partner":"6qqh" + "partner":"6qqk" }, { "sim":200.0, - "partner":"6qqi" + "partner":"6s45" }, { "sim":200.0, - "partner":"6qqj" + "partner":"8a4e" }, { "sim":200.0, - "partner":"6qqk" + "partner":"6s46" }, { "sim":200.0, - "partner":"8a4e" + "partner":"8a2v" }, { "sim":200.0, - "partner":"6s45" + "partner":"8a2w" }, { "sim":200.0, - "partner":"6s46" + "partner":"6qsa" }, { "sim":200.0, - "partner":"8a2v" + "partner":"6qqh" }, { "sim":200.0, - "partner":"8a2w" + "partner":"6qqi" }, { "sim":200.0, - "partner":"6qsa" + "partner":"6qqj" }, { "sim":195.0, @@ -498898,17 +500919,13 @@ "sim":124.0, "partner":"6i23" }, - { - "sim":123.0, - "partner":"6i22" - }, { "sim":123.0, "partner":"6i20" }, { "sim":123.0, - "partner":"6i24" + "partner":"6i22" }, { "sim":123.0, @@ -498918,6 +500935,10 @@ "sim":123.0, "partner":"6i21" }, + { + "sim":123.0, + "partner":"6i24" + }, { "sim":119.0, "partner":"4gcz" @@ -498984,19 +501005,19 @@ }, { "sim":105.0, - "partner":"4kuo" + "partner":"4kuk" }, { "sim":105.0, - "partner":"4kuk" + "partner":"4kuo" }, { "sim":104.0, - "partner":"8pm1" + "partner":"6rhf" }, { "sim":104.0, - "partner":"6rhf" + "partner":"8pm1" }, { "sim":104.0, @@ -499028,35 +501049,35 @@ }, { "sim":102.0, - "partner":"6yxb" + "partner":"6yx6" }, { "sim":102.0, - "partner":"6yx4" + "partner":"7oo9" }, { "sim":102.0, - "partner":"6yxc" + "partner":"6ywg" }, { "sim":102.0, - "partner":"6yx6" + "partner":"6ywh" }, { "sim":102.0, - "partner":"7oo9" + "partner":"7ab7" }, { "sim":102.0, - "partner":"6ywg" + "partner":"6yxb" }, { "sim":102.0, - "partner":"6ywh" + "partner":"6yx4" }, { "sim":102.0, - "partner":"7ab7" + "partner":"6yxc" }, { "sim":102.0, @@ -499090,10 +501111,6 @@ "sim":92.0, "partner":"3rh8" }, - { - "sim":91.0, - "partner":"2pd8" - }, { "sim":91.0, "partner":"3d72" @@ -499108,11 +501125,11 @@ }, { "sim":91.0, - "partner":"6cny" + "partner":"2pd8" }, { "sim":91.0, - "partner":"3hjk" + "partner":"6cny" }, { "sim":91.0, @@ -499122,6 +501139,10 @@ "sim":91.0, "partner":"3hji" }, + { + "sim":91.0, + "partner":"3hjk" + }, { "sim":86.0, "partner":"8a5r" @@ -499196,15 +501217,15 @@ }, { "sim":68.0, - "partner":"3sw1" + "partner":"5j3w" }, { "sim":68.0, - "partner":"5j3w" + "partner":"5j4e" }, { "sim":68.0, - "partner":"5j4e" + "partner":"3sw1" }, { "sim":68.0, @@ -499286,10 +501307,6 @@ "sim":62.0, "partner":"6pby" }, - { - "sim":61.0, - "partner":"7yij" - }, { "sim":61.0, "partner":"7yid" @@ -499310,6 +501327,10 @@ "sim":61.0, "partner":"7yih" }, + { + "sim":61.0, + "partner":"7yij" + }, { "sim":50.0, "partner":"3ewk" @@ -499369,8 +501390,8 @@ ], "subtitle":"Lov2-darpin fusion : d11", "tags":[ - "light switching", - "de novo protein" + "de novo protein", + "light switching" ], "keywords":[ "description", @@ -499475,7 +501496,7 @@ }, { "sim":240.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":240.0, @@ -499483,7 +501504,7 @@ }, { "sim":240.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":239.0, @@ -499531,11 +501552,11 @@ }, { "sim":226.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":226.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":225.0, @@ -499547,11 +501568,11 @@ }, { "sim":222.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":222.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":222.0, @@ -499563,7 +501584,7 @@ }, { "sim":220.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":220.0, @@ -499571,19 +501592,15 @@ }, { "sim":220.0, - "partner":"5lw2" - }, - { - "sim":220.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":220.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":220.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":220.0, @@ -499591,15 +501608,15 @@ }, { "sim":220.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":220.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":220.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":220.0, @@ -499607,11 +501624,11 @@ }, { "sim":220.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":220.0, - "partner":"8ql4" + "partner":"5lw2" }, { "sim":220.0, @@ -499619,23 +501636,27 @@ }, { "sim":220.0, - "partner":"8qlb" + "partner":"8ql4" }, { "sim":220.0, "partner":"8ql2" }, + { + "sim":220.0, + "partner":"8ql5" + }, { "sim":220.0, "partner":"8v9o" }, { "sim":219.0, - "partner":"7dne" + "partner":"2xeh" }, { "sim":219.0, - "partner":"2xeh" + "partner":"7dne" }, { "sim":219.0, @@ -499711,11 +501732,11 @@ }, { "sim":174.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":174.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":171.0, @@ -499769,6 +501790,10 @@ "sim":155.0, "partner":"5kba" }, + { + "sim":153.0, + "partner":"9glq" + }, { "sim":123.0, "partner":"2xen" @@ -499821,11 +501846,11 @@ }, { "sim":252.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":252.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":250.0, @@ -499871,10 +501896,6 @@ "sim":241.0, "partner":"5hzk" }, - { - "sim":240.0, - "partner":"5dju" - }, { "sim":240.0, "partner":"5efw" @@ -499885,7 +501906,7 @@ }, { "sim":240.0, - "partner":"2v0u" + "partner":"5dju" }, { "sim":240.0, @@ -499899,6 +501920,10 @@ "sim":240.0, "partner":"7pgy" }, + { + "sim":240.0, + "partner":"2v0u" + }, { "sim":240.0, "partner":"6mok" @@ -500059,45 +502084,25 @@ "sim":223.0, "partner":"4hna" }, - { - "sim":222.0, - "partner":"5eno" - }, - { - "sim":222.0, - "partner":"6zob" - }, - { - "sim":222.0, - "partner":"6zo5" - }, { "sim":222.0, "partner":"4dx6" }, { "sim":222.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":222.0, "partner":"6zoc" }, - { - "sim":222.0, - "partner":"5enp" - }, - { - "sim":222.0, - "partner":"6sgs" - }, { "sim":222.0, "partner":"6zo6" }, { "sim":222.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":222.0, @@ -500105,7 +502110,7 @@ }, { "sim":222.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":222.0, @@ -500113,11 +502118,11 @@ }, { "sim":222.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":222.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":222.0, @@ -500127,6 +502132,10 @@ "sim":222.0, "partner":"6zoe" }, + { + "sim":222.0, + "partner":"5enq" + }, { "sim":222.0, "partner":"6q4p" @@ -500137,19 +502146,19 @@ }, { "sim":222.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":222.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":222.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":222.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":222.0, @@ -500161,23 +502170,23 @@ }, { "sim":222.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":222.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":222.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":222.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":222.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":222.0, @@ -500189,15 +502198,15 @@ }, { "sim":222.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":222.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":222.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":222.0, @@ -500205,15 +502214,19 @@ }, { "sim":222.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":222.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":222.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":222.0, + "partner":"6sgr" }, { "sim":222.0, @@ -500229,12 +502242,24 @@ }, { "sim":222.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":222.0, "partner":"4dx5" }, + { + "sim":222.0, + "partner":"5eno" + }, + { + "sim":222.0, + "partner":"6zo5" + }, + { + "sim":222.0, + "partner":"6q4n" + }, { "sim":222.0, "partner":"4hrl" @@ -500269,11 +502294,11 @@ }, { "sim":220.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":220.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":220.0, @@ -500283,30 +502308,18 @@ "sim":220.0, "partner":"6bbn" }, - { - "sim":220.0, - "partner":"7yz0" - }, { "sim":220.0, "partner":"6mzf" }, { "sim":220.0, - "partner":"7yz1" - }, - { - "sim":220.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":220.0, "partner":"5nqt" }, - { - "sim":220.0, - "partner":"6mze" - }, { "sim":220.0, "partner":"7yz2" @@ -500317,11 +502330,11 @@ }, { "sim":220.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":220.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":220.0, @@ -500335,13 +502348,17 @@ "sim":220.0, "partner":"7yz5" }, + { + "sim":220.0, + "partner":"7yz6" + }, { "sim":220.0, "partner":"4lnu" }, { "sim":220.0, - "partner":"7yz6" + "partner":"6zwb" }, { "sim":220.0, @@ -500355,10 +502372,6 @@ "sim":220.0, "partner":"5nm5" }, - { - "sim":220.0, - "partner":"6zwb" - }, { "sim":220.0, "partner":"6zwc" @@ -500371,6 +502384,18 @@ "sim":220.0, "partner":"7yyz" }, + { + "sim":220.0, + "partner":"7yz0" + }, + { + "sim":220.0, + "partner":"7yz1" + }, + { + "sim":220.0, + "partner":"7z01" + }, { "sim":220.0, "partner":"4k5c" @@ -500417,11 +502442,11 @@ }, { "sim":216.0, - "partner":"2y1l" + "partner":"6gvm" }, { "sim":216.0, - "partner":"6gvm" + "partner":"2y1l" }, { "sim":216.0, @@ -500443,10 +502468,6 @@ "sim":215.0, "partner":"6qfo" }, - { - "sim":214.0, - "partner":"5oyj" - }, { "sim":214.0, "partner":"4ydy" @@ -500459,6 +502480,10 @@ "sim":214.0, "partner":"6gvn" }, + { + "sim":214.0, + "partner":"5oyj" + }, { "sim":214.0, "partner":"6moj" @@ -500557,11 +502582,11 @@ }, { "sim":200.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":200.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":199.0, @@ -500585,43 +502610,43 @@ }, { "sim":198.0, - "partner":"6qqh" + "partner":"6qqk" }, { "sim":198.0, - "partner":"6qqi" + "partner":"6s45" }, { "sim":198.0, - "partner":"6qqj" + "partner":"8a4e" }, { "sim":198.0, - "partner":"6qqk" + "partner":"6s46" }, { "sim":198.0, - "partner":"8a4e" + "partner":"8a2v" }, { "sim":198.0, - "partner":"6s45" + "partner":"8a2w" }, { "sim":198.0, - "partner":"6s46" + "partner":"6qsa" }, { "sim":198.0, - "partner":"8a2v" + "partner":"6qqh" }, { "sim":198.0, - "partner":"8a2w" + "partner":"6qqi" }, { "sim":198.0, - "partner":"6qsa" + "partner":"6qqj" }, { "sim":198.0, @@ -500657,11 +502682,11 @@ }, { "sim":188.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":188.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":187.0, @@ -500671,10 +502696,6 @@ "sim":181.0, "partner":"6ne2" }, - { - "sim":180.0, - "partner":"7pd8" - }, { "sim":180.0, "partner":"7pdd" @@ -500687,6 +502708,10 @@ "sim":180.0, "partner":"7pdh" }, + { + "sim":180.0, + "partner":"7pd8" + }, { "sim":180.0, "partner":"6ne4" @@ -500761,23 +502786,23 @@ }, { "sim":157.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":157.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":157.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":157.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":157.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":157.0, @@ -500785,11 +502810,11 @@ }, { "sim":157.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":157.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":157.0, @@ -500879,10 +502904,6 @@ "sim":128.0, "partner":"3ulf" }, - { - "sim":127.0, - "partner":"5vhj" - }, { "sim":127.0, "partner":"5vhh" @@ -500913,15 +502934,15 @@ }, { "sim":127.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":127.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":127.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":127.0, @@ -500931,6 +502952,10 @@ "sim":127.0, "partner":"7vxw" }, + { + "sim":127.0, + "partner":"1uoh" + }, { "sim":127.0, "partner":"7vy4" @@ -500941,11 +502966,11 @@ }, { "sim":127.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":127.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":127.0, @@ -500999,17 +503024,13 @@ "sim":125.0, "partner":"6i23" }, - { - "sim":125.0, - "partner":"6i22" - }, { "sim":125.0, "partner":"6i20" }, { "sim":125.0, - "partner":"6i24" + "partner":"6i22" }, { "sim":125.0, @@ -501021,16 +503042,20 @@ }, { "sim":125.0, - "partner":"5aar" + "partner":"6i24" }, { "sim":125.0, - "partner":"4cym" + "partner":"5aar" }, { "sim":125.0, "partner":"4cz2" }, + { + "sim":125.0, + "partner":"4cym" + }, { "sim":125.0, "partner":"3aji" @@ -501209,11 +503234,11 @@ }, { "sim":108.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":108.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":108.0, @@ -501269,11 +503294,11 @@ }, { "sim":105.0, - "partner":"4kuo" + "partner":"4kuk" }, { "sim":105.0, - "partner":"4kuk" + "partner":"4kuo" }, { "sim":105.0, @@ -501293,11 +503318,11 @@ }, { "sim":104.0, - "partner":"8pm1" + "partner":"6rhf" }, { "sim":104.0, - "partner":"6rhf" + "partner":"8pm1" }, { "sim":104.0, @@ -501339,18 +503364,6 @@ "sim":103.0, "partner":"2z6c" }, - { - "sim":102.0, - "partner":"6yxb" - }, - { - "sim":102.0, - "partner":"6yx4" - }, - { - "sim":102.0, - "partner":"6yxc" - }, { "sim":102.0, "partner":"6yx6" @@ -501373,19 +503386,23 @@ }, { "sim":102.0, - "partner":"1bd8" + "partner":"6yxb" }, { "sim":102.0, - "partner":"1bi8" + "partner":"6yx4" }, { "sim":102.0, - "partner":"6m11" + "partner":"6yxc" }, { "sim":102.0, - "partner":"6m12" + "partner":"1bd8" + }, + { + "sim":102.0, + "partner":"1bi8" }, { "sim":102.0, @@ -501411,6 +503428,14 @@ "sim":102.0, "partner":"4o1p" }, + { + "sim":102.0, + "partner":"6m11" + }, + { + "sim":102.0, + "partner":"6m12" + }, { "sim":101.0, "partner":"6ywq" @@ -501463,10 +503488,6 @@ "sim":97.0, "partner":"3f6q" }, - { - "sim":97.0, - "partner":"6v9x" - }, { "sim":97.0, "partner":"6v9y" @@ -501479,6 +503500,10 @@ "sim":97.0, "partner":"6v9w" }, + { + "sim":97.0, + "partner":"6v9x" + }, { "sim":97.0, "partner":"7or0" @@ -501575,10 +503600,6 @@ "sim":92.0, "partner":"1g3n" }, - { - "sim":91.0, - "partner":"2pd8" - }, { "sim":91.0, "partner":"3d72" @@ -501593,11 +503614,11 @@ }, { "sim":91.0, - "partner":"6cny" + "partner":"2pd8" }, { "sim":91.0, - "partner":"3hjk" + "partner":"6cny" }, { "sim":91.0, @@ -501607,6 +503628,10 @@ "sim":91.0, "partner":"3hji" }, + { + "sim":91.0, + "partner":"3hjk" + }, { "sim":91.0, "partner":"2rfm" @@ -501673,11 +503698,11 @@ }, { "sim":87.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":87.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":83.0, @@ -501697,19 +503722,19 @@ }, { "sim":81.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":81.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":81.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":81.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":80.0, @@ -501741,15 +503766,15 @@ }, { "sim":76.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":76.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":76.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":76.0, @@ -501787,10 +503812,6 @@ "sim":74.0, "partner":"5wo6" }, - { - "sim":74.0, - "partner":"5iwr" - }, { "sim":74.0, "partner":"5iwt" @@ -501843,6 +503864,10 @@ "sim":74.0, "partner":"5iwp" }, + { + "sim":74.0, + "partner":"5iwr" + }, { "sim":74.0, "partner":"5wo7" @@ -501883,10 +503908,6 @@ "sim":71.0, "partner":"5luv" }, - { - "sim":71.0, - "partner":"6o1p" - }, { "sim":71.0, "partner":"6b5v" @@ -501925,7 +503946,7 @@ }, { "sim":71.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":71.0, @@ -501959,6 +503980,10 @@ "sim":71.0, "partner":"7t6l" }, + { + "sim":71.0, + "partner":"7t6m" + }, { "sim":70.0, "partner":"7yx0" @@ -501969,15 +503994,15 @@ }, { "sim":69.0, - "partner":"3sw1" + "partner":"5j3w" }, { "sim":69.0, - "partner":"5j3w" + "partner":"5j4e" }, { "sim":69.0, - "partner":"5j4e" + "partner":"3sw1" }, { "sim":68.0, @@ -502039,10 +504064,6 @@ "sim":66.0, "partner":"4hj6" }, - { - "sim":66.0, - "partner":"7k4a" - }, { "sim":66.0, "partner":"7k4b" @@ -502065,7 +504086,7 @@ }, { "sim":66.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":66.0, @@ -502081,7 +504102,7 @@ }, { "sim":66.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":66.0, @@ -502093,7 +504114,7 @@ }, { "sim":66.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":66.0, @@ -502111,6 +504132,10 @@ "sim":66.0, "partner":"6bo8" }, + { + "sim":66.0, + "partner":"6bo9" + }, { "sim":65.0, "partner":"6y7q" @@ -502171,10 +504196,6 @@ "sim":63.0, "partner":"6pby" }, - { - "sim":63.0, - "partner":"7yij" - }, { "sim":63.0, "partner":"7yid" @@ -502195,6 +504216,10 @@ "sim":63.0, "partner":"7yih" }, + { + "sim":63.0, + "partner":"7yij" + }, { "sim":62.0, "partner":"4hoi" @@ -502205,11 +504230,11 @@ }, { "sim":58.0, - "partner":"7ttr" + "partner":"7tts" }, { "sim":58.0, - "partner":"7tts" + "partner":"7ttr" }, { "sim":57.0, @@ -502251,10 +504276,6 @@ "sim":56.0, "partner":"5is0" }, - { - "sim":56.0, - "partner":"7mzc" - }, { "sim":56.0, "partner":"7l2v" @@ -502317,7 +504338,7 @@ }, { "sim":56.0, - "partner":"7l2n" + "partner":"7mzc" }, { "sim":56.0, @@ -502353,20 +504374,16 @@ }, { "sim":56.0, - "partner":"7lpd" + "partner":"7l2n" }, { "sim":56.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":56.0, "partner":"7rqv" }, - { - "sim":56.0, - "partner":"7lpe" - }, { "sim":56.0, "partner":"7rqw" @@ -502399,10 +504416,22 @@ "sim":56.0, "partner":"7lpc" }, + { + "sim":56.0, + "partner":"7rqu" + }, + { + "sim":56.0, + "partner":"7lpd" + }, { "sim":54.0, "partner":"6l93" }, + { + "sim":54.0, + "partner":"8ycp" + }, { "sim":54.0, "partner":"8gf8" @@ -502494,8 +504523,8 @@ ], "subtitle":"Lov2-darpin fusion : d12", "tags":[ - "light switching", - "de novo protein" + "de novo protein", + "light switching" ], "keywords":[ "description", @@ -502576,7 +504605,7 @@ }, { "sim":244.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":244.0, @@ -502584,7 +504613,7 @@ }, { "sim":244.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":243.0, @@ -502652,11 +504681,11 @@ }, { "sim":229.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":229.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":227.0, @@ -502664,15 +504693,15 @@ }, { "sim":226.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":226.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":226.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":226.0, @@ -502680,15 +504709,15 @@ }, { "sim":226.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":226.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":226.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":226.0, @@ -502696,15 +504725,15 @@ }, { "sim":226.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":226.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":226.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":226.0, @@ -502712,23 +504741,23 @@ }, { "sim":226.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":226.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":226.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":226.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":226.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":225.0, @@ -502740,11 +504769,11 @@ }, { "sim":224.0, - "partner":"7dne" + "partner":"2xeh" }, { "sim":224.0, - "partner":"2xeh" + "partner":"7dne" }, { "sim":223.0, @@ -502840,11 +504869,11 @@ }, { "sim":174.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":174.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":171.0, @@ -502852,11 +504881,11 @@ }, { "sim":168.0, - "partner":"4gpm" + "partner":"4hb5" }, { "sim":168.0, - "partner":"4hb5" + "partner":"4gpm" }, { "sim":166.0, @@ -502880,11 +504909,11 @@ }, { "sim":160.0, - "partner":"5kba" + "partner":"5hry" }, { "sim":160.0, - "partner":"5hry" + "partner":"5kba" }, { "sim":159.0, @@ -502894,6 +504923,10 @@ "sim":159.0, "partner":"5hs0" }, + { + "sim":153.0, + "partner":"9glq" + }, { "sim":123.0, "partner":"2xen" @@ -502966,15 +504999,15 @@ }, { "sim":260.0, - "partner":"5dju" + "partner":"5efw" }, { "sim":260.0, - "partner":"5efw" + "partner":"5djt" }, { "sim":260.0, - "partner":"5djt" + "partner":"5dju" }, { "sim":260.0, @@ -502992,10 +505025,6 @@ "sim":257.0, "partner":"2v1b" }, - { - "sim":257.0, - "partner":"2v0u" - }, { "sim":257.0, "partner":"2v0w" @@ -503008,6 +505037,10 @@ "sim":257.0, "partner":"7pgy" }, + { + "sim":257.0, + "partner":"2v0u" + }, { "sim":254.0, "partner":"7pgz" @@ -503094,11 +505127,11 @@ }, { "sim":236.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":236.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":236.0, @@ -503148,45 +505181,25 @@ "sim":228.0, "partner":"2v5q" }, - { - "sim":228.0, - "partner":"5eno" - }, - { - "sim":228.0, - "partner":"6zob" - }, - { - "sim":228.0, - "partner":"6zo5" - }, { "sim":228.0, "partner":"4dx6" }, { "sim":228.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":228.0, "partner":"6zoc" }, - { - "sim":228.0, - "partner":"5enp" - }, - { - "sim":228.0, - "partner":"6sgs" - }, { "sim":228.0, "partner":"6zo6" }, { "sim":228.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":228.0, @@ -503194,7 +505207,7 @@ }, { "sim":228.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":228.0, @@ -503202,11 +505215,11 @@ }, { "sim":228.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":228.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":228.0, @@ -503218,31 +505231,31 @@ }, { "sim":228.0, - "partner":"6q4p" + "partner":"5enq" }, { "sim":228.0, - "partner":"6sgt" + "partner":"6q4p" }, { "sim":228.0, - "partner":"7ouk" + "partner":"6sgt" }, { "sim":228.0, - "partner":"2j8s" + "partner":"7b8s" }, { "sim":228.0, - "partner":"4u96" + "partner":"7ouk" }, { "sim":228.0, - "partner":"7b8s" + "partner":"2j8s" }, { "sim":228.0, - "partner":"3noc" + "partner":"4u96" }, { "sim":228.0, @@ -503254,15 +505267,15 @@ }, { "sim":228.0, - "partner":"5enr" + "partner":"3noc" }, { "sim":228.0, - "partner":"4u8v" + "partner":"6sgu" }, { "sim":228.0, - "partner":"6sgu" + "partner":"5enr" }, { "sim":228.0, @@ -503270,7 +505283,11 @@ }, { "sim":228.0, - "partner":"5nc5" + "partner":"4u8v" + }, + { + "sim":228.0, + "partner":"7b8t" }, { "sim":228.0, @@ -503282,15 +505299,15 @@ }, { "sim":228.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":228.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":228.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":228.0, @@ -503302,15 +505319,15 @@ }, { "sim":228.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":228.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":228.0, - "partner":"6zoh" + "partner":"4u8y" }, { "sim":228.0, @@ -503320,6 +505337,10 @@ "sim":228.0, "partner":"4hna" }, + { + "sim":228.0, + "partner":"6sgr" + }, { "sim":228.0, "partner":"4c48" @@ -503334,12 +505355,24 @@ }, { "sim":228.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":228.0, "partner":"4dx5" }, + { + "sim":228.0, + "partner":"5eno" + }, + { + "sim":228.0, + "partner":"6zo5" + }, + { + "sim":228.0, + "partner":"6q4n" + }, { "sim":228.0, "partner":"5mla" @@ -503364,21 +505397,17 @@ "sim":226.0, "partner":"6s8k" }, - { - "sim":226.0, - "partner":"7pjf" - }, { "sim":226.0, "partner":"6s8l" }, { "sim":226.0, - "partner":"6bbn" + "partner":"7pjf" }, { "sim":226.0, - "partner":"7yz0" + "partner":"6bbn" }, { "sim":226.0, @@ -503386,20 +505415,12 @@ }, { "sim":226.0, - "partner":"7yz1" - }, - { - "sim":226.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":226.0, "partner":"5nqt" }, - { - "sim":226.0, - "partner":"6mze" - }, { "sim":226.0, "partner":"7yz2" @@ -503410,11 +505431,11 @@ }, { "sim":226.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":226.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":226.0, @@ -503424,13 +505445,17 @@ "sim":226.0, "partner":"7yz5" }, + { + "sim":226.0, + "partner":"7yz6" + }, { "sim":226.0, "partner":"4lnu" }, { "sim":226.0, - "partner":"7yz6" + "partner":"6zwb" }, { "sim":226.0, @@ -503444,10 +505469,6 @@ "sim":226.0, "partner":"5nm5" }, - { - "sim":226.0, - "partner":"6zwb" - }, { "sim":226.0, "partner":"6zwc" @@ -503460,6 +505481,18 @@ "sim":226.0, "partner":"7yyz" }, + { + "sim":226.0, + "partner":"7yz0" + }, + { + "sim":226.0, + "partner":"7yz1" + }, + { + "sim":226.0, + "partner":"7z01" + }, { "sim":226.0, "partner":"7n2b" @@ -503562,15 +505595,15 @@ }, { "sim":219.0, - "partner":"5oyj" + "partner":"4ydy" }, { "sim":219.0, - "partner":"4ydy" + "partner":"2p2c" }, { "sim":219.0, - "partner":"2p2c" + "partner":"5oyj" }, { "sim":218.0, @@ -503674,11 +505707,11 @@ }, { "sim":203.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":203.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":201.0, @@ -503698,43 +505731,43 @@ }, { "sim":200.0, - "partner":"6qqh" + "partner":"6qqk" }, { "sim":200.0, - "partner":"6qqi" + "partner":"6s45" }, { "sim":200.0, - "partner":"6qqj" + "partner":"8a4e" }, { "sim":200.0, - "partner":"6qqk" + "partner":"6s46" }, { "sim":200.0, - "partner":"8a4e" + "partner":"8a2v" }, { "sim":200.0, - "partner":"6s45" + "partner":"8a2w" }, { "sim":200.0, - "partner":"6s46" + "partner":"6qsa" }, { "sim":200.0, - "partner":"8a2v" + "partner":"6qqh" }, { "sim":200.0, - "partner":"8a2w" + "partner":"6qqi" }, { "sim":200.0, - "partner":"6qsa" + "partner":"6qqj" }, { "sim":200.0, @@ -503778,20 +505811,16 @@ }, { "sim":190.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":190.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":185.0, "partner":"6moi" }, - { - "sim":180.0, - "partner":"7pd8" - }, { "sim":180.0, "partner":"7pdd" @@ -503804,6 +505833,10 @@ "sim":180.0, "partner":"7pdh" }, + { + "sim":180.0, + "partner":"7pd8" + }, { "sim":179.0, "partner":"6d66" @@ -503906,23 +505939,23 @@ }, { "sim":129.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":129.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":129.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":129.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":129.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":129.0, @@ -503930,11 +505963,11 @@ }, { "sim":129.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":129.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":129.0, @@ -504028,17 +506061,13 @@ "sim":122.0, "partner":"6i23" }, - { - "sim":122.0, - "partner":"6i22" - }, { "sim":122.0, "partner":"6i20" }, { "sim":122.0, - "partner":"6i24" + "partner":"6i22" }, { "sim":122.0, @@ -504048,6 +506077,10 @@ "sim":122.0, "partner":"6i21" }, + { + "sim":122.0, + "partner":"6i24" + }, { "sim":117.0, "partner":"2z6d" @@ -504158,11 +506191,11 @@ }, { "sim":105.0, - "partner":"4kuo" + "partner":"4kuk" }, { "sim":105.0, - "partner":"4kuk" + "partner":"4kuo" }, { "sim":105.0, @@ -504170,11 +506203,11 @@ }, { "sim":104.0, - "partner":"8pm1" + "partner":"6rhf" }, { "sim":104.0, - "partner":"6rhf" + "partner":"8pm1" }, { "sim":104.0, @@ -504192,10 +506225,6 @@ "sim":104.0, "partner":"6gbv" }, - { - "sim":104.0, - "partner":"5vhj" - }, { "sim":104.0, "partner":"5vhh" @@ -504226,15 +506255,15 @@ }, { "sim":104.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":104.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":104.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":104.0, @@ -504244,6 +506273,10 @@ "sim":104.0, "partner":"7vxw" }, + { + "sim":104.0, + "partner":"1uoh" + }, { "sim":104.0, "partner":"7vy4" @@ -504254,11 +506287,11 @@ }, { "sim":104.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":104.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":104.0, @@ -504270,15 +506303,15 @@ }, { "sim":104.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":104.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":104.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":104.0, @@ -504338,35 +506371,35 @@ }, { "sim":102.0, - "partner":"6yxb" + "partner":"6yx6" }, { "sim":102.0, - "partner":"6yx4" + "partner":"7oo9" }, { "sim":102.0, - "partner":"6yxc" + "partner":"6ywg" }, { "sim":102.0, - "partner":"6yx6" + "partner":"6ywh" }, { "sim":102.0, - "partner":"7oo9" + "partner":"7ab7" }, { "sim":102.0, - "partner":"6ywg" + "partner":"6yxb" }, { "sim":102.0, - "partner":"6ywh" + "partner":"6yx4" }, { "sim":102.0, - "partner":"7ab7" + "partner":"6yxc" }, { "sim":102.0, @@ -504414,11 +506447,11 @@ }, { "sim":101.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":101.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":101.0, @@ -504486,11 +506519,11 @@ }, { "sim":95.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":95.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":95.0, @@ -504536,10 +506569,6 @@ "sim":92.0, "partner":"7lyc" }, - { - "sim":91.0, - "partner":"2pd8" - }, { "sim":91.0, "partner":"3d72" @@ -504554,11 +506583,11 @@ }, { "sim":91.0, - "partner":"6cny" + "partner":"2pd8" }, { "sim":91.0, - "partner":"3hjk" + "partner":"6cny" }, { "sim":91.0, @@ -504568,6 +506597,10 @@ "sim":91.0, "partner":"3hji" }, + { + "sim":91.0, + "partner":"3hjk" + }, { "sim":91.0, "partner":"5d66" @@ -504656,14 +506689,6 @@ "sim":86.0, "partner":"6py8" }, - { - "sim":86.0, - "partner":"6m11" - }, - { - "sim":86.0, - "partner":"6m12" - }, { "sim":86.0, "partner":"6m13" @@ -504688,6 +506713,14 @@ "sim":86.0, "partner":"4o1p" }, + { + "sim":86.0, + "partner":"6m11" + }, + { + "sim":86.0, + "partner":"6m12" + }, { "sim":85.0, "partner":"3v30" @@ -504716,10 +506749,6 @@ "sim":85.0, "partner":"6wj5" }, - { - "sim":85.0, - "partner":"6v9x" - }, { "sim":85.0, "partner":"6v9y" @@ -504732,6 +506761,10 @@ "sim":85.0, "partner":"6v9w" }, + { + "sim":85.0, + "partner":"6v9x" + }, { "sim":85.0, "partner":"7or0" @@ -504878,15 +506911,15 @@ }, { "sim":74.0, - "partner":"5svu" + "partner":"5svv" }, { "sim":74.0, - "partner":"5svv" + "partner":"5svw" }, { "sim":74.0, - "partner":"5svw" + "partner":"5svu" }, { "sim":74.0, @@ -504896,21 +506929,17 @@ "sim":73.0, "partner":"6wle" }, - { - "sim":73.0, - "partner":"1k1a" - }, { "sim":73.0, "partner":"1k1b" }, { "sim":73.0, - "partner":"5wo6" + "partner":"1k1a" }, { "sim":73.0, - "partner":"5iwr" + "partner":"5wo6" }, { "sim":73.0, @@ -504964,6 +506993,10 @@ "sim":73.0, "partner":"5iwp" }, + { + "sim":73.0, + "partner":"5iwr" + }, { "sim":73.0, "partner":"5wo7" @@ -504974,15 +507007,15 @@ }, { "sim":72.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":72.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":72.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":72.0, @@ -505032,10 +507065,6 @@ "sim":69.0, "partner":"7obz" }, - { - "sim":68.0, - "partner":"3sw1" - }, { "sim":68.0, "partner":"5j3w" @@ -505046,7 +507075,7 @@ }, { "sim":68.0, - "partner":"6o1p" + "partner":"3sw1" }, { "sim":68.0, @@ -505086,7 +507115,7 @@ }, { "sim":68.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":68.0, @@ -505120,6 +507149,10 @@ "sim":68.0, "partner":"7t6l" }, + { + "sim":68.0, + "partner":"7t6m" + }, { "sim":67.0, "partner":"8pef" @@ -505212,10 +507245,6 @@ "sim":64.0, "partner":"3ljn" }, - { - "sim":64.0, - "partner":"7k4a" - }, { "sim":64.0, "partner":"7k4b" @@ -505238,7 +507267,7 @@ }, { "sim":64.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":64.0, @@ -505254,7 +507283,7 @@ }, { "sim":64.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":64.0, @@ -505266,7 +507295,7 @@ }, { "sim":64.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":64.0, @@ -505284,6 +507313,10 @@ "sim":64.0, "partner":"6bo8" }, + { + "sim":64.0, + "partner":"6bo9" + }, { "sim":63.0, "partner":"5j7e" @@ -505320,10 +507353,6 @@ "sim":62.0, "partner":"6pby" }, - { - "sim":61.0, - "partner":"7yij" - }, { "sim":61.0, "partner":"7yid" @@ -505344,6 +507373,10 @@ "sim":61.0, "partner":"7yih" }, + { + "sim":61.0, + "partner":"7yij" + }, { "sim":60.0, "partner":"1k3z" @@ -505358,11 +507391,11 @@ }, { "sim":57.0, - "partner":"7ttr" + "partner":"7tts" }, { "sim":57.0, - "partner":"7tts" + "partner":"7ttr" }, { "sim":56.0, @@ -505376,6 +507409,10 @@ "sim":54.0, "partner":"6l93" }, + { + "sim":53.0, + "partner":"8ycp" + }, { "sim":53.0, "partner":"8gf8" @@ -505432,10 +507469,6 @@ "sim":51.0, "partner":"5is0" }, - { - "sim":51.0, - "partner":"7mzc" - }, { "sim":51.0, "partner":"7l2v" @@ -505498,7 +507531,7 @@ }, { "sim":51.0, - "partner":"7l2n" + "partner":"7mzc" }, { "sim":51.0, @@ -505534,32 +507567,28 @@ }, { "sim":51.0, - "partner":"7lqy" + "partner":"7l2n" }, { "sim":51.0, - "partner":"7lqz" + "partner":"7lqy" }, { "sim":51.0, - "partner":"7lr0" + "partner":"7lqz" }, { "sim":51.0, - "partner":"7lpd" + "partner":"7lr0" }, { "sim":51.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":51.0, "partner":"7rqv" }, - { - "sim":51.0, - "partner":"7lpe" - }, { "sim":51.0, "partner":"7rqw" @@ -505591,6 +507620,14 @@ { "sim":51.0, "partner":"7lpc" + }, + { + "sim":51.0, + "partner":"7rqu" + }, + { + "sim":51.0, + "partner":"7lpd" } ], "struct_thr_sim_designed":[ @@ -505647,8 +507684,8 @@ ], "subtitle":"Lov2-darpin fusion : d7", "tags":[ - "light switching", - "de novo protein" + "de novo protein", + "light switching" ], "keywords":[ "description", @@ -505749,7 +507786,7 @@ }, { "sim":244.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":244.0, @@ -505757,7 +507794,7 @@ }, { "sim":244.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":243.0, @@ -505809,11 +507846,11 @@ }, { "sim":226.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":226.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":225.0, @@ -505825,11 +507862,11 @@ }, { "sim":222.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":222.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":220.0, @@ -505837,7 +507874,7 @@ }, { "sim":220.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":220.0, @@ -505845,19 +507882,15 @@ }, { "sim":220.0, - "partner":"5lw2" - }, - { - "sim":220.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":220.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":220.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":220.0, @@ -505865,15 +507898,15 @@ }, { "sim":220.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":220.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":220.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":220.0, @@ -505881,11 +507914,11 @@ }, { "sim":220.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":220.0, - "partner":"8ql4" + "partner":"5lw2" }, { "sim":220.0, @@ -505893,23 +507926,27 @@ }, { "sim":220.0, - "partner":"8qlb" + "partner":"8ql4" }, { "sim":220.0, "partner":"8ql2" }, + { + "sim":220.0, + "partner":"8ql5" + }, { "sim":220.0, "partner":"8v9o" }, { "sim":219.0, - "partner":"7dne" + "partner":"2xeh" }, { "sim":219.0, - "partner":"2xeh" + "partner":"7dne" }, { "sim":219.0, @@ -505989,11 +508026,11 @@ }, { "sim":174.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":174.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":171.0, @@ -506047,6 +508084,10 @@ "sim":155.0, "partner":"5kba" }, + { + "sim":153.0, + "partner":"9glq" + }, { "sim":123.0, "partner":"2xen" @@ -506105,10 +508146,6 @@ "sim":273.0, "partner":"2v1b" }, - { - "sim":273.0, - "partner":"5dju" - }, { "sim":273.0, "partner":"5efw" @@ -506119,7 +508156,7 @@ }, { "sim":273.0, - "partner":"2v0u" + "partner":"5dju" }, { "sim":273.0, @@ -506133,6 +508170,10 @@ "sim":273.0, "partner":"7pgy" }, + { + "sim":273.0, + "partner":"2v0u" + }, { "sim":273.0, "partner":"2wkp" @@ -506179,11 +508220,11 @@ }, { "sim":255.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":255.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":254.0, @@ -506337,45 +508378,25 @@ "sim":223.0, "partner":"4hna" }, - { - "sim":222.0, - "partner":"5eno" - }, - { - "sim":222.0, - "partner":"6zob" - }, - { - "sim":222.0, - "partner":"6zo5" - }, { "sim":222.0, "partner":"4dx6" }, { "sim":222.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":222.0, "partner":"6zoc" }, - { - "sim":222.0, - "partner":"5enp" - }, - { - "sim":222.0, - "partner":"6sgs" - }, { "sim":222.0, "partner":"6zo6" }, { "sim":222.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":222.0, @@ -506383,7 +508404,7 @@ }, { "sim":222.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":222.0, @@ -506391,11 +508412,11 @@ }, { "sim":222.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":222.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":222.0, @@ -506405,6 +508426,10 @@ "sim":222.0, "partner":"6zoe" }, + { + "sim":222.0, + "partner":"5enq" + }, { "sim":222.0, "partner":"6q4p" @@ -506415,19 +508440,19 @@ }, { "sim":222.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":222.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":222.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":222.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":222.0, @@ -506439,23 +508464,23 @@ }, { "sim":222.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":222.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":222.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":222.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":222.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":222.0, @@ -506467,15 +508492,15 @@ }, { "sim":222.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":222.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":222.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":222.0, @@ -506483,15 +508508,19 @@ }, { "sim":222.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":222.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":222.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":222.0, + "partner":"6sgr" }, { "sim":222.0, @@ -506507,12 +508536,24 @@ }, { "sim":222.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":222.0, "partner":"4dx5" }, + { + "sim":222.0, + "partner":"5eno" + }, + { + "sim":222.0, + "partner":"6zo5" + }, + { + "sim":222.0, + "partner":"6q4n" + }, { "sim":222.0, "partner":"4hrl" @@ -506535,11 +508576,11 @@ }, { "sim":220.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":220.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":220.0, @@ -506549,30 +508590,18 @@ "sim":220.0, "partner":"6bbn" }, - { - "sim":220.0, - "partner":"7yz0" - }, { "sim":220.0, "partner":"6mzf" }, { "sim":220.0, - "partner":"7yz1" - }, - { - "sim":220.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":220.0, "partner":"5nqt" }, - { - "sim":220.0, - "partner":"6mze" - }, { "sim":220.0, "partner":"7yz2" @@ -506583,11 +508612,11 @@ }, { "sim":220.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":220.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":220.0, @@ -506601,13 +508630,17 @@ "sim":220.0, "partner":"7yz5" }, + { + "sim":220.0, + "partner":"7yz6" + }, { "sim":220.0, "partner":"4lnu" }, { "sim":220.0, - "partner":"7yz6" + "partner":"6zwb" }, { "sim":220.0, @@ -506621,10 +508654,6 @@ "sim":220.0, "partner":"5nm5" }, - { - "sim":220.0, - "partner":"6zwb" - }, { "sim":220.0, "partner":"6zwc" @@ -506637,6 +508666,18 @@ "sim":220.0, "partner":"7yyz" }, + { + "sim":220.0, + "partner":"7yz0" + }, + { + "sim":220.0, + "partner":"7yz1" + }, + { + "sim":220.0, + "partner":"7z01" + }, { "sim":220.0, "partner":"7alr" @@ -506699,11 +508740,11 @@ }, { "sim":216.0, - "partner":"2y1l" + "partner":"6gvm" }, { "sim":216.0, - "partner":"6gvm" + "partner":"2y1l" }, { "sim":216.0, @@ -506721,10 +508762,6 @@ "sim":215.0, "partner":"6qep" }, - { - "sim":214.0, - "partner":"5oyj" - }, { "sim":214.0, "partner":"4ydy" @@ -506737,6 +508774,10 @@ "sim":214.0, "partner":"6gvn" }, + { + "sim":214.0, + "partner":"5oyj" + }, { "sim":213.0, "partner":"8dw2" @@ -506855,51 +508896,51 @@ }, { "sim":200.0, - "partner":"6qqh" + "partner":"6qqk" }, { "sim":200.0, - "partner":"6qqi" + "partner":"6s45" }, { "sim":200.0, - "partner":"6qqj" + "partner":"8a4e" }, { "sim":200.0, - "partner":"6qqk" + "partner":"6s46" }, { "sim":200.0, - "partner":"8a4e" + "partner":"8a2v" }, { "sim":200.0, - "partner":"6s45" + "partner":"8a2w" }, { "sim":200.0, - "partner":"6s46" + "partner":"6qsa" }, { "sim":200.0, - "partner":"8a2v" + "partner":"6qqh" }, { "sim":200.0, - "partner":"8a2w" + "partner":"6qqi" }, { "sim":200.0, - "partner":"6qsa" + "partner":"6qqj" }, { "sim":200.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":200.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":199.0, @@ -506937,17 +508978,13 @@ "sim":190.0, "partner":"6gpv" }, - { - "sim":188.0, - "partner":"6mog" - }, { "sim":188.0, "partner":"6moh" }, { - "sim":180.0, - "partner":"7pd8" + "sim":188.0, + "partner":"6mog" }, { "sim":180.0, @@ -506961,6 +508998,10 @@ "sim":180.0, "partner":"7pdh" }, + { + "sim":180.0, + "partner":"7pd8" + }, { "sim":179.0, "partner":"6d66" @@ -507031,23 +509072,23 @@ }, { "sim":157.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":157.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":157.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":157.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":157.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":157.0, @@ -507055,11 +509096,11 @@ }, { "sim":157.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":157.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":157.0, @@ -507191,11 +509232,11 @@ }, { "sim":125.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":125.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":124.0, @@ -507209,17 +509250,13 @@ "sim":124.0, "partner":"4rly" }, - { - "sim":123.0, - "partner":"6i22" - }, { "sim":123.0, "partner":"6i20" }, { "sim":123.0, - "partner":"6i24" + "partner":"6i22" }, { "sim":123.0, @@ -507229,6 +509266,10 @@ "sim":123.0, "partner":"6i21" }, + { + "sim":123.0, + "partner":"6i24" + }, { "sim":122.0, "partner":"6xkc" @@ -507339,11 +509380,11 @@ }, { "sim":109.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":109.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":109.0, @@ -507395,11 +509436,11 @@ }, { "sim":105.0, - "partner":"4kuo" + "partner":"4kuk" }, { "sim":105.0, - "partner":"4kuk" + "partner":"4kuo" }, { "sim":105.0, @@ -507411,11 +509452,11 @@ }, { "sim":104.0, - "partner":"8pm1" + "partner":"6rhf" }, { "sim":104.0, - "partner":"6rhf" + "partner":"8pm1" }, { "sim":104.0, @@ -507447,35 +509488,35 @@ }, { "sim":102.0, - "partner":"6yxb" + "partner":"6yx6" }, { "sim":102.0, - "partner":"6yx4" + "partner":"7oo9" }, { "sim":102.0, - "partner":"6yxc" + "partner":"6ywg" }, { "sim":102.0, - "partner":"6yx6" + "partner":"6ywh" }, { "sim":102.0, - "partner":"7oo9" + "partner":"7ab7" }, { "sim":102.0, - "partner":"6ywg" + "partner":"6yxb" }, { "sim":102.0, - "partner":"6ywh" + "partner":"6yx4" }, { "sim":102.0, - "partner":"7ab7" + "partner":"6yxc" }, { "sim":102.0, @@ -507501,14 +509542,6 @@ "sim":101.0, "partner":"8pky" }, - { - "sim":100.0, - "partner":"6m11" - }, - { - "sim":100.0, - "partner":"6m12" - }, { "sim":100.0, "partner":"6m13" @@ -507533,6 +509566,14 @@ "sim":100.0, "partner":"4o1p" }, + { + "sim":100.0, + "partner":"6m11" + }, + { + "sim":100.0, + "partner":"6m12" + }, { "sim":99.0, "partner":"1blx" @@ -507609,10 +509650,6 @@ "sim":92.0, "partner":"7ddx" }, - { - "sim":91.0, - "partner":"2pd8" - }, { "sim":91.0, "partner":"3d72" @@ -507627,11 +509664,11 @@ }, { "sim":91.0, - "partner":"6cny" + "partner":"2pd8" }, { "sim":91.0, - "partner":"3hjk" + "partner":"6cny" }, { "sim":91.0, @@ -507641,6 +509678,10 @@ "sim":91.0, "partner":"3hji" }, + { + "sim":91.0, + "partner":"3hjk" + }, { "sim":89.0, "partner":"3v30" @@ -507655,11 +509696,11 @@ }, { "sim":87.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":87.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":86.0, @@ -507695,19 +509736,19 @@ }, { "sim":80.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":80.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":80.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":80.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":80.0, @@ -507731,15 +509772,15 @@ }, { "sim":76.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":76.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":76.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":76.0, @@ -507765,10 +509806,6 @@ "sim":74.0, "partner":"5wo6" }, - { - "sim":74.0, - "partner":"5iwr" - }, { "sim":74.0, "partner":"5iwt" @@ -507821,6 +509858,10 @@ "sim":74.0, "partner":"5iwp" }, + { + "sim":74.0, + "partner":"5iwr" + }, { "sim":74.0, "partner":"5wo7" @@ -507869,10 +509910,6 @@ "sim":71.0, "partner":"7a6p" }, - { - "sim":71.0, - "partner":"6o1p" - }, { "sim":71.0, "partner":"6b5v" @@ -507911,7 +509948,7 @@ }, { "sim":71.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":71.0, @@ -507945,6 +509982,10 @@ "sim":71.0, "partner":"7t6l" }, + { + "sim":71.0, + "partner":"7t6m" + }, { "sim":70.0, "partner":"5luv" @@ -507955,15 +509996,15 @@ }, { "sim":68.0, - "partner":"3sw1" + "partner":"5j3w" }, { "sim":68.0, - "partner":"5j3w" + "partner":"5j4e" }, { "sim":68.0, - "partner":"5j4e" + "partner":"3sw1" }, { "sim":68.0, @@ -508001,10 +510042,6 @@ "sim":67.0, "partner":"1oy3" }, - { - "sim":67.0, - "partner":"7k4a" - }, { "sim":67.0, "partner":"7k4b" @@ -508027,7 +510064,7 @@ }, { "sim":67.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":67.0, @@ -508043,7 +510080,7 @@ }, { "sim":67.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":67.0, @@ -508055,7 +510092,7 @@ }, { "sim":67.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":67.0, @@ -508073,6 +510110,10 @@ "sim":67.0, "partner":"6bo8" }, + { + "sim":67.0, + "partner":"6bo9" + }, { "sim":66.0, "partner":"8a36" @@ -508157,10 +510198,6 @@ "sim":61.0, "partner":"7xbk" }, - { - "sim":61.0, - "partner":"7yij" - }, { "sim":61.0, "partner":"7yid" @@ -508181,6 +510218,10 @@ "sim":61.0, "partner":"7yih" }, + { + "sim":61.0, + "partner":"7yij" + }, { "sim":57.0, "partner":"2pnn" @@ -508217,10 +510258,6 @@ "sim":57.0, "partner":"5is0" }, - { - "sim":57.0, - "partner":"7mzc" - }, { "sim":57.0, "partner":"7l2v" @@ -508283,7 +510320,7 @@ }, { "sim":57.0, - "partner":"7l2n" + "partner":"7mzc" }, { "sim":57.0, @@ -508319,20 +510356,16 @@ }, { "sim":57.0, - "partner":"7lpd" + "partner":"7l2n" }, { "sim":57.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":57.0, "partner":"7rqv" }, - { - "sim":57.0, - "partner":"7lpe" - }, { "sim":57.0, "partner":"7rqw" @@ -508365,17 +510398,25 @@ "sim":57.0, "partner":"7lpc" }, + { + "sim":57.0, + "partner":"7rqu" + }, + { + "sim":57.0, + "partner":"7lpd" + }, { "sim":55.0, "partner":"7us2" }, { "sim":55.0, - "partner":"7ttr" + "partner":"7tts" }, { "sim":55.0, - "partner":"7tts" + "partner":"7ttr" }, { "sim":54.0, @@ -508385,6 +510426,10 @@ "sim":53.0, "partner":"6l93" }, + { + "sim":53.0, + "partner":"8ycp" + }, { "sim":53.0, "partner":"7lqy" @@ -508492,8 +510537,8 @@ ], "subtitle":"Lov2-darpin fusion: d13", "tags":[ - "light-switching", - "de novo protein" + "de novo protein", + "light-switching" ], "keywords":[ "description", @@ -508594,7 +510639,7 @@ }, { "sim":240.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":240.0, @@ -508602,7 +510647,7 @@ }, { "sim":240.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":239.0, @@ -508654,11 +510699,11 @@ }, { "sim":226.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":226.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":225.0, @@ -508670,11 +510715,11 @@ }, { "sim":222.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":222.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":220.0, @@ -508682,7 +510727,7 @@ }, { "sim":220.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":220.0, @@ -508690,19 +510735,15 @@ }, { "sim":220.0, - "partner":"5lw2" - }, - { - "sim":220.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":220.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":220.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":220.0, @@ -508710,15 +510751,15 @@ }, { "sim":220.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":220.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":220.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":220.0, @@ -508726,11 +510767,11 @@ }, { "sim":220.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":220.0, - "partner":"8ql4" + "partner":"5lw2" }, { "sim":220.0, @@ -508738,23 +510779,27 @@ }, { "sim":220.0, - "partner":"8qlb" + "partner":"8ql4" }, { "sim":220.0, "partner":"8ql2" }, + { + "sim":220.0, + "partner":"8ql5" + }, { "sim":220.0, "partner":"8v9o" }, { "sim":219.0, - "partner":"7dne" + "partner":"2xeh" }, { "sim":219.0, - "partner":"2xeh" + "partner":"7dne" }, { "sim":219.0, @@ -508834,11 +510879,11 @@ }, { "sim":174.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":174.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":171.0, @@ -508892,6 +510937,10 @@ "sim":155.0, "partner":"5kba" }, + { + "sim":153.0, + "partner":"9glq" + }, { "sim":139.0, "partner":"5cwo" @@ -508954,10 +511003,6 @@ "sim":267.0, "partner":"5hzi" }, - { - "sim":265.0, - "partner":"5dju" - }, { "sim":265.0, "partner":"5efw" @@ -508968,7 +511013,7 @@ }, { "sim":265.0, - "partner":"2v0u" + "partner":"5dju" }, { "sim":265.0, @@ -508982,6 +511027,10 @@ "sim":265.0, "partner":"7pgy" }, + { + "sim":265.0, + "partner":"2v0u" + }, { "sim":265.0, "partner":"5h76" @@ -509032,11 +511081,11 @@ }, { "sim":254.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":254.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":253.0, @@ -509190,45 +511239,25 @@ "sim":223.0, "partner":"4hna" }, - { - "sim":222.0, - "partner":"5eno" - }, - { - "sim":222.0, - "partner":"6zob" - }, - { - "sim":222.0, - "partner":"6zo5" - }, { "sim":222.0, "partner":"4dx6" }, { "sim":222.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":222.0, "partner":"6zoc" }, - { - "sim":222.0, - "partner":"5enp" - }, - { - "sim":222.0, - "partner":"6sgs" - }, { "sim":222.0, "partner":"6zo6" }, { "sim":222.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":222.0, @@ -509236,7 +511265,7 @@ }, { "sim":222.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":222.0, @@ -509244,11 +511273,11 @@ }, { "sim":222.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":222.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":222.0, @@ -509258,6 +511287,10 @@ "sim":222.0, "partner":"6zoe" }, + { + "sim":222.0, + "partner":"5enq" + }, { "sim":222.0, "partner":"6q4p" @@ -509268,19 +511301,19 @@ }, { "sim":222.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":222.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":222.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":222.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":222.0, @@ -509292,23 +511325,23 @@ }, { "sim":222.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":222.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":222.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":222.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":222.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":222.0, @@ -509320,15 +511353,15 @@ }, { "sim":222.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":222.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":222.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":222.0, @@ -509336,15 +511369,19 @@ }, { "sim":222.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":222.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":222.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":222.0, + "partner":"6sgr" }, { "sim":222.0, @@ -509360,12 +511397,24 @@ }, { "sim":222.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":222.0, "partner":"4dx5" }, + { + "sim":222.0, + "partner":"5eno" + }, + { + "sim":222.0, + "partner":"6zo5" + }, + { + "sim":222.0, + "partner":"6q4n" + }, { "sim":222.0, "partner":"4hrl" @@ -509400,11 +511449,11 @@ }, { "sim":220.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":220.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":220.0, @@ -509414,30 +511463,18 @@ "sim":220.0, "partner":"6bbn" }, - { - "sim":220.0, - "partner":"7yz0" - }, { "sim":220.0, "partner":"6mzf" }, { "sim":220.0, - "partner":"7yz1" - }, - { - "sim":220.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":220.0, "partner":"5nqt" }, - { - "sim":220.0, - "partner":"6mze" - }, { "sim":220.0, "partner":"7yz2" @@ -509448,11 +511485,11 @@ }, { "sim":220.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":220.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":220.0, @@ -509466,13 +511503,17 @@ "sim":220.0, "partner":"7yz5" }, + { + "sim":220.0, + "partner":"7yz6" + }, { "sim":220.0, "partner":"4lnu" }, { "sim":220.0, - "partner":"7yz6" + "partner":"6zwb" }, { "sim":220.0, @@ -509486,10 +511527,6 @@ "sim":220.0, "partner":"5nm5" }, - { - "sim":220.0, - "partner":"6zwb" - }, { "sim":220.0, "partner":"6zwc" @@ -509502,6 +511539,18 @@ "sim":220.0, "partner":"7yyz" }, + { + "sim":220.0, + "partner":"7yz0" + }, + { + "sim":220.0, + "partner":"7yz1" + }, + { + "sim":220.0, + "partner":"7z01" + }, { "sim":220.0, "partner":"6sh9" @@ -509548,11 +511597,11 @@ }, { "sim":216.0, - "partner":"2y1l" + "partner":"6gvm" }, { "sim":216.0, - "partner":"6gvm" + "partner":"2y1l" }, { "sim":216.0, @@ -509574,10 +511623,6 @@ "sim":215.0, "partner":"6moe" }, - { - "sim":214.0, - "partner":"5oyj" - }, { "sim":214.0, "partner":"4ydy" @@ -509590,6 +511635,10 @@ "sim":214.0, "partner":"6gvn" }, + { + "sim":214.0, + "partner":"5oyj" + }, { "sim":213.0, "partner":"8dw2" @@ -509680,11 +511729,11 @@ }, { "sim":200.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":200.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":199.0, @@ -509700,43 +511749,43 @@ }, { "sim":196.0, - "partner":"6qqh" + "partner":"6qqk" }, { "sim":196.0, - "partner":"6qqi" + "partner":"6s45" }, { "sim":196.0, - "partner":"6qqj" + "partner":"8a4e" }, { "sim":196.0, - "partner":"6qqk" + "partner":"6s46" }, { "sim":196.0, - "partner":"8a4e" + "partner":"8a2v" }, { "sim":196.0, - "partner":"6s45" + "partner":"8a2w" }, { "sim":196.0, - "partner":"6s46" + "partner":"6qsa" }, { "sim":196.0, - "partner":"8a2v" + "partner":"6qqh" }, { "sim":196.0, - "partner":"8a2w" + "partner":"6qqi" }, { "sim":196.0, - "partner":"6qsa" + "partner":"6qqj" }, { "sim":196.0, @@ -509784,11 +511833,11 @@ }, { "sim":188.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":188.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":186.0, @@ -509806,10 +511855,6 @@ "sim":181.0, "partner":"6ne4" }, - { - "sim":180.0, - "partner":"7pd8" - }, { "sim":180.0, "partner":"7pdd" @@ -509822,6 +511867,10 @@ "sim":180.0, "partner":"7pdh" }, + { + "sim":180.0, + "partner":"7pd8" + }, { "sim":179.0, "partner":"6d66" @@ -509892,23 +511941,23 @@ }, { "sim":157.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":157.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":157.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":157.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":157.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":157.0, @@ -509916,11 +511965,11 @@ }, { "sim":157.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":157.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":157.0, @@ -509978,10 +512027,6 @@ "sim":135.0, "partner":"8hae" }, - { - "sim":133.0, - "partner":"5vhj" - }, { "sim":133.0, "partner":"5vhh" @@ -510012,15 +512057,15 @@ }, { "sim":133.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":133.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":133.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":133.0, @@ -510030,6 +512075,10 @@ "sim":133.0, "partner":"7vxw" }, + { + "sim":133.0, + "partner":"1uoh" + }, { "sim":133.0, "partner":"7vy4" @@ -510040,11 +512089,11 @@ }, { "sim":133.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":133.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":133.0, @@ -510120,11 +512169,11 @@ }, { "sim":125.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":125.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":124.0, @@ -510162,17 +512211,13 @@ "sim":122.0, "partner":"6i23" }, - { - "sim":122.0, - "partner":"6i22" - }, { "sim":122.0, "partner":"6i20" }, { "sim":122.0, - "partner":"6i24" + "partner":"6i22" }, { "sim":122.0, @@ -510182,6 +512227,10 @@ "sim":122.0, "partner":"6i21" }, + { + "sim":122.0, + "partner":"6i24" + }, { "sim":122.0, "partner":"4z68" @@ -510348,11 +512397,11 @@ }, { "sim":108.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":108.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":108.0, @@ -510396,11 +512445,11 @@ }, { "sim":102.0, - "partner":"4kuo" + "partner":"4kuk" }, { "sim":102.0, - "partner":"4kuk" + "partner":"4kuo" }, { "sim":102.0, @@ -510414,14 +512463,6 @@ "sim":102.0, "partner":"1ot8" }, - { - "sim":102.0, - "partner":"6m11" - }, - { - "sim":102.0, - "partner":"6m12" - }, { "sim":102.0, "partner":"6m13" @@ -510446,6 +512487,14 @@ "sim":102.0, "partner":"4o1p" }, + { + "sim":102.0, + "partner":"6m11" + }, + { + "sim":102.0, + "partner":"6m12" + }, { "sim":101.0, "partner":"6gba" @@ -510460,11 +512509,11 @@ }, { "sim":100.0, - "partner":"8pm1" + "partner":"6rhf" }, { "sim":100.0, - "partner":"6rhf" + "partner":"8pm1" }, { "sim":100.0, @@ -510492,43 +512541,43 @@ }, { "sim":98.0, - "partner":"6yxb" + "partner":"6yx6" }, { "sim":98.0, - "partner":"6yx4" + "partner":"7oo9" }, { "sim":98.0, - "partner":"6yxc" + "partner":"6ywg" }, { "sim":98.0, - "partner":"6yx6" + "partner":"6ywq" }, { "sim":98.0, - "partner":"7oo9" + "partner":"6ywh" }, { "sim":98.0, - "partner":"6ywg" + "partner":"6ywr" }, { "sim":98.0, - "partner":"6ywq" + "partner":"7ab7" }, { "sim":98.0, - "partner":"6ywh" + "partner":"6yxb" }, { "sim":98.0, - "partner":"6ywr" + "partner":"6yx4" }, { "sim":98.0, - "partner":"7ab7" + "partner":"6yxc" }, { "sim":98.0, @@ -510562,10 +512611,6 @@ "sim":97.0, "partner":"3f6q" }, - { - "sim":97.0, - "partner":"6v9x" - }, { "sim":97.0, "partner":"6v9y" @@ -510578,6 +512623,10 @@ "sim":97.0, "partner":"6v9w" }, + { + "sim":97.0, + "partner":"6v9x" + }, { "sim":97.0, "partner":"7or0" @@ -510702,10 +512751,6 @@ "sim":90.0, "partner":"1mx2" }, - { - "sim":89.0, - "partner":"2pd8" - }, { "sim":89.0, "partner":"3d72" @@ -510720,11 +512765,11 @@ }, { "sim":89.0, - "partner":"6cny" + "partner":"2pd8" }, { "sim":89.0, - "partner":"3hjk" + "partner":"6cny" }, { "sim":89.0, @@ -510734,6 +512779,10 @@ "sim":89.0, "partner":"3hji" }, + { + "sim":89.0, + "partner":"3hjk" + }, { "sim":89.0, "partner":"3v30" @@ -510772,11 +512821,11 @@ }, { "sim":87.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":87.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":86.0, @@ -510804,19 +512853,19 @@ }, { "sim":82.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":82.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":82.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":82.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":81.0, @@ -510848,15 +512897,15 @@ }, { "sim":76.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":76.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":76.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":76.0, @@ -510878,10 +512927,6 @@ "sim":74.0, "partner":"5wo6" }, - { - "sim":74.0, - "partner":"5iwr" - }, { "sim":74.0, "partner":"5iwt" @@ -510934,6 +512979,10 @@ "sim":74.0, "partner":"5iwp" }, + { + "sim":74.0, + "partner":"5iwr" + }, { "sim":74.0, "partner":"5wo7" @@ -510952,15 +513001,15 @@ }, { "sim":72.0, - "partner":"5svu" + "partner":"5svv" }, { "sim":72.0, - "partner":"5svv" + "partner":"5svw" }, { "sim":72.0, - "partner":"5svw" + "partner":"5svu" }, { "sim":72.0, @@ -510974,10 +513023,6 @@ "sim":71.0, "partner":"6wle" }, - { - "sim":71.0, - "partner":"6o1p" - }, { "sim":71.0, "partner":"6b5v" @@ -511016,7 +513061,7 @@ }, { "sim":71.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":71.0, @@ -511050,6 +513095,10 @@ "sim":71.0, "partner":"7t6l" }, + { + "sim":71.0, + "partner":"7t6m" + }, { "sim":70.0, "partner":"6gg9" @@ -511080,15 +513129,15 @@ }, { "sim":67.0, - "partner":"3sw1" + "partner":"5j3w" }, { "sim":67.0, - "partner":"5j3w" + "partner":"5j4e" }, { "sim":67.0, - "partner":"5j4e" + "partner":"3sw1" }, { "sim":67.0, @@ -511106,10 +513155,6 @@ "sim":66.0, "partner":"7obz" }, - { - "sim":66.0, - "partner":"7k4a" - }, { "sim":66.0, "partner":"7k4b" @@ -511132,7 +513177,7 @@ }, { "sim":66.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":66.0, @@ -511148,7 +513193,7 @@ }, { "sim":66.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":66.0, @@ -511160,7 +513205,7 @@ }, { "sim":66.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":66.0, @@ -511178,6 +513223,10 @@ "sim":66.0, "partner":"6bo8" }, + { + "sim":66.0, + "partner":"6bo9" + }, { "sim":65.0, "partner":"6y7q" @@ -511258,10 +513307,6 @@ "sim":61.0, "partner":"5k7l" }, - { - "sim":61.0, - "partner":"7yij" - }, { "sim":61.0, "partner":"7yid" @@ -511282,6 +513327,10 @@ "sim":61.0, "partner":"7yih" }, + { + "sim":61.0, + "partner":"7yij" + }, { "sim":60.0, "partner":"4hoi" @@ -511312,11 +513361,11 @@ }, { "sim":58.0, - "partner":"7ttr" + "partner":"7tts" }, { "sim":58.0, - "partner":"7tts" + "partner":"7ttr" }, { "sim":57.0, @@ -511358,10 +513407,6 @@ "sim":57.0, "partner":"5is0" }, - { - "sim":57.0, - "partner":"7mzc" - }, { "sim":57.0, "partner":"7l2v" @@ -511424,7 +513469,7 @@ }, { "sim":57.0, - "partner":"7l2n" + "partner":"7mzc" }, { "sim":57.0, @@ -511460,20 +513505,16 @@ }, { "sim":57.0, - "partner":"7lpd" + "partner":"7l2n" }, { "sim":57.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":57.0, "partner":"7rqv" }, - { - "sim":57.0, - "partner":"7lpe" - }, { "sim":57.0, "partner":"7rqw" @@ -511506,6 +513547,14 @@ "sim":57.0, "partner":"7lpc" }, + { + "sim":57.0, + "partner":"7rqu" + }, + { + "sim":57.0, + "partner":"7lpd" + }, { "sim":56.0, "partner":"8deh" @@ -511522,6 +513571,10 @@ "sim":53.0, "partner":"5h2c" }, + { + "sim":53.0, + "partner":"8ycp" + }, { "sim":53.0, "partner":"7lqy" @@ -511625,9 +513678,9 @@ ], "subtitle":"Crystal structure of de novo designed protein, sewn0.1", "tags":[ - "g protein", + "de novo protein", "binder", - "de novo protein" + "g protein" ], "keywords":[ "description", @@ -511751,96 +513804,96 @@ ], "subtitle":"Porous framework formed by assembly of a bipyridyl-conjugated helical peptide", "tags":[ + "uic-1", + "de novo protein", + "alpha", + "porous", "assembly", + "helix", "framework", - "alpha", "bipyridine", - "de novo protein", - "porous", - "310", - "uic-1", - "helix" + "310" ], "keywords":[ - "facile", - "evolution", - "acidic", - "restricted", - "herein", + "affinity", + "allow", + "organic", + "development", + "pore", + "featuring", + "framework", + "provided", + "short", "strategy", + "significantly", + "sophisticated", + "demonstrate", + "hindered", + "promise", + "induced", + "using", + "choice", + "complex", + "however", "metal", + "due", + "residues", + "proteomimetic", + "great", + "level", + "frameworks", + "behaviors", + "incompatible", + "optimization", + "proteins", "ions", - "featuring", - "substantially", - "allow", - "basic", - "choice", - "induced", + "units", + "evolution", + "unprecedented", + "longer", + "restricted", + "increase", "variable", - "sequences", - "synthetic", - "validate", - "however", - "affinity", "molecule", - "even", - "longer", - "proteins", - "variants", - "pore", - "short", + "exhibit", "simpler", - "materials", - "assemble", + "design", + "multimetallic", "hallmark", - "units", - "structures", + "fit", + "provides", + "even", "assembly", - "behaviors", - "significantly", - "exhibit", - "incompatible", - "much", - "provided", - "previously", - "framework", - "toward", - "powerful", - "guide", - "frameworks", - "optimization", - "tolerate", "shown", - "organic", - "provides", - "compatible", - "design", - "promise", - "multimetallic", - "using", - "blueprint", - "variations", - "increase", + "validate", "functionalities", - "hindered", - "great", - "sophisticated", - "demonstrate", - "capabilities", "noncovalent", - "unprecedented", - "rational", + "substantially", "peptides", - "residues", - "due", - "bipyridyl", - "complex", - "development", - "proteomimetic", - "fit", - "crystalline", "developed", - "level" + "toward", + "capabilities", + "materials", + "crystalline", + "basic", + "sequences", + "variants", + "structures", + "rational", + "previously", + "blueprint", + "bipyridyl", + "synthetic", + "acidic", + "tolerate", + "herein", + "powerful", + "compatible", + "much", + "guide", + "assemble", + "variations", + "facile" ], "release_date":"2022-04-20", "publication":"\"Assembly of pi-Stacking Helical Peptides into a Porous and Multivariable Proteomimetic Framework\", J.Am.Chem.Soc., 144, 7001-7009", @@ -511958,96 +514011,96 @@ ], "subtitle":"Porous framework formed by assembly of a bipyridyl-conjugated helical peptide", "tags":[ + "uic-1", + "de novo protein", + "alpha", + "porous", "assembly", + "helix", "framework", - "alpha", "bipyridine", - "de novo protein", - "porous", - "310", - "uic-1", - "helix" + "310" ], "keywords":[ - "facile", - "evolution", - "acidic", - "restricted", - "herein", + "affinity", + "allow", + "organic", + "development", + "pore", + "featuring", + "framework", + "provided", + "short", "strategy", + "significantly", + "sophisticated", + "demonstrate", + "hindered", + "promise", + "induced", + "using", + "choice", + "complex", + "however", "metal", + "due", + "residues", + "proteomimetic", + "great", + "level", + "frameworks", + "behaviors", + "incompatible", + "optimization", + "proteins", "ions", - "featuring", - "substantially", - "allow", - "basic", - "choice", - "induced", + "units", + "evolution", + "unprecedented", + "longer", + "restricted", + "increase", "variable", - "sequences", - "synthetic", - "validate", - "however", - "affinity", "molecule", - "even", - "longer", - "proteins", - "variants", - "pore", - "short", + "exhibit", "simpler", - "materials", - "assemble", + "design", + "multimetallic", "hallmark", - "units", - "structures", + "fit", + "provides", + "even", "assembly", - "behaviors", - "significantly", - "exhibit", - "incompatible", - "much", - "provided", - "previously", - "framework", - "toward", - "powerful", - "guide", - "frameworks", - "optimization", - "tolerate", "shown", - "organic", - "provides", - "compatible", - "design", - "promise", - "multimetallic", - "using", - "blueprint", - "variations", - "increase", + "validate", "functionalities", - "hindered", - "great", - "sophisticated", - "demonstrate", - "capabilities", "noncovalent", - "unprecedented", - "rational", + "substantially", "peptides", - "residues", - "due", - "bipyridyl", - "complex", - "development", - "proteomimetic", - "fit", - "crystalline", "developed", - "level" + "toward", + "capabilities", + "materials", + "crystalline", + "basic", + "sequences", + "variants", + "structures", + "rational", + "previously", + "blueprint", + "bipyridyl", + "synthetic", + "acidic", + "tolerate", + "herein", + "powerful", + "compatible", + "much", + "guide", + "assemble", + "variations", + "facile" ], "release_date":"2022-04-20", "publication":"\"Assembly of pi-Stacking Helical Peptides into a Porous and Multivariable Proteomimetic Framework\", J.Am.Chem.Soc., 144, 7001-7009", @@ -512165,96 +514218,96 @@ ], "subtitle":"Porous framework formed by assembly of a bipyridyl-conjugated helical peptide", "tags":[ + "uic-1", + "de novo protein", + "alpha", + "porous", "assembly", + "helix", "framework", - "alpha", "bipyridine", - "de novo protein", - "porous", - "310", - "uic-1", - "helix" + "310" ], "keywords":[ - "facile", - "evolution", - "acidic", - "restricted", - "herein", + "affinity", + "allow", + "organic", + "development", + "pore", + "featuring", + "framework", + "provided", + "short", "strategy", + "significantly", + "sophisticated", + "demonstrate", + "hindered", + "promise", + "induced", + "using", + "choice", + "complex", + "however", "metal", + "due", + "residues", + "proteomimetic", + "great", + "level", + "frameworks", + "behaviors", + "incompatible", + "optimization", + "proteins", "ions", - "featuring", - "substantially", - "allow", - "basic", - "choice", - "induced", + "units", + "evolution", + "unprecedented", + "longer", + "restricted", + "increase", "variable", - "sequences", - "synthetic", - "validate", - "however", - "affinity", "molecule", - "even", - "longer", - "proteins", - "variants", - "pore", - "short", + "exhibit", "simpler", - "materials", - "assemble", + "design", + "multimetallic", "hallmark", - "units", 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"compatible", + "much", + "guide", + "assemble", + "variations", + "facile" ], "release_date":"2022-04-20", "publication":"\"Assembly of pi-Stacking Helical Peptides into a Porous and Multivariable Proteomimetic Framework\", J.Am.Chem.Soc., 144, 7001-7009", @@ -512372,96 +514425,96 @@ ], "subtitle":"Porous framework formed by assembly of a bipyridyl-conjugated helical peptide", "tags":[ + "uic-1", + "de novo protein", + "alpha", + "porous", "assembly", + "helix", "framework", - "alpha", "bipyridine", - "de novo protein", - "porous", - "310", - "uic-1", - "helix" + "310" ], "keywords":[ - "facile", - "evolution", - "acidic", - "restricted", - "herein", + "affinity", + "allow", + "organic", + "development", + "pore", + "featuring", + "framework", + "provided", + "short", "strategy", + "significantly", + "sophisticated", + "demonstrate", + "hindered", + "promise", + "induced", + "using", + "choice", + "complex", + "however", "metal", + "due", + "residues", + "proteomimetic", + "great", + 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"helix", "framework", - "alpha", "bipyridine", - "de novo protein", - "porous", - "310", - "uic-1", - "helix" + "310" ], "keywords":[ - "facile", - "evolution", - "acidic", - "restricted", - "herein", + "affinity", + "allow", + "organic", + "development", + "pore", + "featuring", + "framework", + "provided", + "short", "strategy", + "significantly", + "sophisticated", + "demonstrate", + "hindered", + "promise", + "induced", + "using", + "choice", + "complex", + "however", "metal", + "due", + "residues", + "proteomimetic", + "great", + "level", + "frameworks", + "behaviors", + "incompatible", + "optimization", + "proteins", "ions", - "featuring", - "substantially", - "allow", - "basic", - "choice", - "induced", + "units", + "evolution", + "unprecedented", + "longer", + "restricted", + "increase", "variable", - "sequences", - "synthetic", - "validate", - "however", - "affinity", "molecule", - "even", - "longer", - "proteins", - "variants", - "pore", - "short", + "exhibit", "simpler", - 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- "blueprint", - "variations", - "increase", + "validate", "functionalities", - "hindered", - "great", - "sophisticated", - "demonstrate", - "capabilities", "noncovalent", - "unprecedented", - "rational", + "substantially", "peptides", - "residues", - "due", - "bipyridyl", - "complex", - "development", - "proteomimetic", - "fit", - "crystalline", "developed", - "level" + "toward", + "capabilities", + "materials", + "crystalline", + "basic", + "sequences", + "variants", + "structures", + "rational", + "previously", + "blueprint", + "bipyridyl", + "synthetic", + "acidic", + "tolerate", + "herein", + "powerful", + "compatible", + "much", + "guide", + "assemble", + "variations", + "facile" ], "release_date":"2023-01-25", "publication":"\"Assembly of pi-Stacking Helical Peptides into a Porous and Multivariable Proteomimetic Framework\", J.Am.Chem.Soc., 144, 7001-7009", @@ -512993,96 +515046,96 @@ ], "subtitle":"Porous framework formed by assembly of a bipyridyl-conjugated helical peptide", "tags":[ + "uic-1", + "de novo protein", + "alpha", + "porous", "assembly", + "helix", "framework", - "alpha", "bipyridine", - "de novo protein", - "porous", - "310", - "uic-1", - "helix" + "310" ], "keywords":[ - "facile", - "evolution", - "acidic", - "restricted", - "herein", + "affinity", + "allow", + "organic", + "development", + "pore", + "featuring", + "framework", + "provided", + "short", "strategy", + "significantly", + "sophisticated", + "demonstrate", + "hindered", + "promise", + "induced", + "using", + "choice", + "complex", + "however", "metal", + "due", + "residues", + "proteomimetic", + "great", + "level", + "frameworks", + "behaviors", + "incompatible", + "optimization", + "proteins", "ions", - "featuring", - "substantially", - "allow", - "basic", - "choice", - "induced", + "units", + "evolution", + "unprecedented", + "longer", + "restricted", + "increase", "variable", - "sequences", - "synthetic", - "validate", - "however", - "affinity", "molecule", - "even", - 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"provides", - "compatible", - "design", - "promise", - "multimetallic", - "using", - "blueprint", - "variations", - "increase", + "validate", "functionalities", - "hindered", - "great", - "sophisticated", - "demonstrate", - "capabilities", "noncovalent", - "unprecedented", - "rational", + "substantially", "peptides", - "residues", - "due", - "bipyridyl", - "complex", - "development", - "proteomimetic", - "fit", - "crystalline", "developed", - "level" + "toward", + "capabilities", + "materials", + "crystalline", + "basic", + "sequences", + "variants", + "structures", + "rational", + "previously", + "blueprint", + "bipyridyl", + "synthetic", + "acidic", + "tolerate", + "herein", + "powerful", + "compatible", + "much", + "guide", + "assemble", + "variations", + "facile" ], "release_date":"2022-04-20", "publication":"\"Assembly of pi-Stacking Helical Peptides into a Porous and Multivariable Proteomimetic Framework\", J.Am.Chem.Soc., 144, 7001-7009", @@ -513407,96 +515460,96 @@ ], "subtitle":"Porous framework formed by assembly of a bipyridyl-conjugated helical peptide", "tags":[ + "uic-1", + "de novo protein", + "alpha", + "porous", "assembly", + "helix", "framework", - "alpha", "bipyridine", - "de novo protein", - "porous", - "310", - "uic-1", - "helix" + "310" ], "keywords":[ - "facile", - "evolution", - "acidic", - "restricted", - "herein", + "affinity", + "allow", + "organic", + "development", + "pore", + "featuring", + "framework", + "provided", + "short", "strategy", + "significantly", + "sophisticated", + "demonstrate", + "hindered", + "promise", + "induced", + "using", + "choice", + "complex", + "however", "metal", + "due", + "residues", + "proteomimetic", + "great", + "level", + "frameworks", + "behaviors", + "incompatible", + "optimization", + "proteins", "ions", - "featuring", - "substantially", - "allow", - "basic", - "choice", - "induced", + "units", + "evolution", + "unprecedented", + "longer", + "restricted", + "increase", "variable", - 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Proteomimetic Framework\", J.Am.Chem.Soc., 144, 7001-7009", @@ -513829,96 +515882,96 @@ ], "subtitle":"Porous framework formed by assembly of a bipyridyl-conjugated helical peptide", "tags":[ + "uic-1", + "de novo protein", + "alpha", + "porous", "assembly", + "helix", "framework", - "alpha", "bipyridine", - "de novo protein", - "porous", - "310", - "uic-1", - "helix" + "310" ], "keywords":[ - "facile", - "evolution", - "acidic", - "restricted", - "herein", + "affinity", + "allow", + "organic", + "development", + "pore", + "featuring", + "framework", + "provided", + "short", "strategy", + "significantly", + "sophisticated", + "demonstrate", + "hindered", + "promise", + "induced", + "using", + "choice", + "complex", + "however", "metal", + "due", + "residues", + "proteomimetic", + "great", + "level", + "frameworks", + "behaviors", + "incompatible", + "optimization", + "proteins", "ions", - "featuring", - "substantially", - "allow", - "basic", - "choice", - "induced", + "units", + 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"complex", - "development", - "proteomimetic", - "fit", - "crystalline", "developed", - "level" + "toward", + "capabilities", + "materials", + "crystalline", + "basic", + "sequences", + "variants", + "structures", + "rational", + "previously", + "blueprint", + "bipyridyl", + "synthetic", + "acidic", + "tolerate", + "herein", + "powerful", + "compatible", + "much", + "guide", + "assemble", + "variations", + "facile" ], "release_date":"2022-04-20", "publication":"\"Assembly of pi-Stacking Helical Peptides into a Porous and Multivariable Proteomimetic Framework\", J.Am.Chem.Soc., 144, 7001-7009", @@ -514105,89 +516158,89 @@ ], "subtitle":"Solution nmr structure of 9-residue rosetta-designed cyclic peptide d9.16 in d6-dmso with cis\/trans switching", "tags":[ - "switch peptides", - "cis\/trans", + "de novo design", "non natural amino acids", "de novo protein", - "cyclic peptide", - "de novo design", - "membrane permeability" + "switch peptides", + "membrane permeability", + "cis\/trans", + "cyclic peptide" ], "keywords":[ - "predicted", - "35", - "accuracy", - "containing", - "control", - "structural", - "generation", - "designs", + "membranes", + "designed", + "made", + "permeable", + "alternative", "robustly", - "amide", - "engaged", - "membrane", + "orally", "models", + "generation", + "coupled", + "design", + "structural", + "exposed", + "show", + "principles", + "experimental", + "structures", + "therapeutics", + "cross", + "experimentally", + "amide", + "contribute", + "apparent", + "determined", + "residue", "groups", - "membranes", - "use", - "systematically", - "close", - "wide", "noncanonical", - "experimental", - "nh", - "1", - "permeable", - "designed", - "29", - "orally", - "bioavailability", - "peptides", - "macrocycle", - "84", - "10", "bioavailable", - "range", - "fully", - "experimentally", - "modifications", + "control", + "interactions", "state", - "determined", - "cross", - "made", - "ability", - "hydrogen", - "show", - "design", - "bonding", - "apparent", - "characterization", "macrocycles", - "next", - "structures", - "interactions", - "residue", + "membrane", + "wide", + "modifications", + "macrocycle", "lipid", - "therapeutics", + "achieved", + "internal", + "fully", + "accuracy", + "characterization", + "size", + "next", + "close", + "use", "backbone", - "ensuring", + "permeability", + "29", + "1", + "ability", "high", + "bioavailability", + "hydrogen", + "predicted", "favored", - "size", - "184", - "computational", - "permeability", - "principles", - "achieved", "greater", - "coupled", + "engaged", + "peptides", + "range", + "designs", + "10", "oral", - "alternative", - "internal", - "exposed", - "contribute", + "containing", + "computational", + "ensuring", + "35", + "nh", + "systematically", "isoenergetic", - "investigate" + "investigate", + "184", + "84", + "bonding" ], "release_date":"2022-09-14", "publication":"\"Accurate de novo design of membrane-traversing macrocycles\", Cell, 185, 3520-3532.e26", @@ -514375,89 +516428,89 @@ ], "subtitle":"Solution nmr structure of 8-residue rosetta-designed cyclic peptide d8.31 in d6-dmso with cis\/trans switching (a-cc conformation)", "tags":[ - "switch peptides", - "cis\/trans", + "de novo design", "non natural amino acids", "de novo protein", - "cyclic peptide", - "de novo design", - "membrane permeability" + "switch peptides", + "membrane permeability", + "cis\/trans", + "cyclic peptide" ], "keywords":[ - "predicted", - "35", - "accuracy", - "containing", - "control", - "structural", - "generation", - "designs", + "membranes", + "designed", + "made", + "permeable", + "alternative", "robustly", - "amide", - "engaged", - "membrane", + "orally", "models", + "generation", + "coupled", + "design", + "structural", + "exposed", + "show", + "principles", + "experimental", + "structures", + "therapeutics", + "cross", + "experimentally", + "amide", + "contribute", + "apparent", + "determined", + "residue", "groups", - "membranes", - "use", - "systematically", - "close", - "wide", "noncanonical", - "experimental", - "nh", - "1", - "permeable", - "designed", - "29", - "orally", - "bioavailability", - "peptides", - "macrocycle", - "84", - "10", "bioavailable", - "range", - "fully", - "experimentally", - "modifications", + "control", + "interactions", "state", - "determined", - "cross", - "made", - "ability", - "hydrogen", - "show", - "design", - "bonding", - "apparent", - "characterization", "macrocycles", - "next", - "structures", - "interactions", - "residue", + "membrane", + "wide", + "modifications", + "macrocycle", "lipid", - "therapeutics", + "achieved", + "internal", + "fully", + "accuracy", + "characterization", + "size", + "next", + "close", + "use", "backbone", - "ensuring", + "permeability", + "29", + "1", + "ability", "high", + "bioavailability", + "hydrogen", + "predicted", "favored", - "size", - "184", - "computational", - "permeability", - "principles", - "achieved", "greater", - "coupled", + "engaged", + "peptides", + "range", + "designs", + "10", "oral", - "alternative", - "internal", - "exposed", - "contribute", + "containing", + "computational", + "ensuring", + "35", + "nh", + "systematically", "isoenergetic", - "investigate" + "investigate", + "184", + "84", + "bonding" ], "release_date":"2022-09-14", "publication":"\"Accurate de novo design of membrane-traversing macrocycles\", Cell, 185, 3520-3532.e26", @@ -514644,89 +516697,89 @@ ], "subtitle":"Solution nmr structure of 8-residue rosetta-designed cyclic peptide d8.21 in d6-dmso with cis\/trans switching", "tags":[ - "switch peptides", - "cis\/trans", + "de novo design", "non natural amino acids", "de novo protein", - "cyclic peptide", - "de novo design", - "membrane permeability" + "switch peptides", + "membrane permeability", + "cis\/trans", + "cyclic peptide" ], "keywords":[ - "predicted", - "35", - "accuracy", - "containing", - "control", - "structural", - "generation", - "designs", + "membranes", + "designed", + "made", + "permeable", + "alternative", "robustly", - "amide", - "engaged", - "membrane", + "orally", "models", + "generation", + "coupled", + "design", + "structural", + "exposed", + "show", + "principles", + "experimental", + "structures", + "therapeutics", + "cross", + "experimentally", + "amide", + "contribute", + "apparent", + "determined", + "residue", "groups", - "membranes", - "use", - "systematically", - "close", - "wide", "noncanonical", - "experimental", - "nh", - "1", - "permeable", - "designed", - "29", - "orally", - "bioavailability", - "peptides", - "macrocycle", - "84", - "10", "bioavailable", - "range", - "fully", - "experimentally", - "modifications", + "control", + "interactions", "state", - "determined", - "cross", - "made", - "ability", - "hydrogen", - "show", - "design", - "bonding", - "apparent", - "characterization", "macrocycles", - "next", - "structures", - "interactions", - "residue", + "membrane", + "wide", + "modifications", + "macrocycle", "lipid", - "therapeutics", + "achieved", + "internal", + "fully", + "accuracy", + "characterization", + "size", + "next", + "close", + "use", "backbone", - "ensuring", + "permeability", + "29", + "1", + "ability", "high", + "bioavailability", + "hydrogen", + "predicted", "favored", - "size", - "184", - "computational", - "permeability", - "principles", - "achieved", "greater", - "coupled", + "engaged", + "peptides", + "range", + "designs", + "10", "oral", - "alternative", - "internal", - "exposed", - "contribute", + "containing", + "computational", + "ensuring", + "35", + "nh", + "systematically", "isoenergetic", - "investigate" + "investigate", + "184", + "84", + "bonding" ], "release_date":"2022-09-14", "publication":"\"Accurate de novo design of membrane-traversing macrocycles\", Cell, 185, 3520-3532.e26", @@ -514913,89 +516966,89 @@ ], "subtitle":"Solution nmr structure of 8-residue rosetta-designed cyclic peptide d8.21 in 50% d6-dmso and 50% water with cis\/trans switching (cc conformation, 50%)", "tags":[ - "switch peptides", - "cis\/trans", + "de novo design", "non natural amino acids", "de novo protein", - "cyclic peptide", - "de novo design", - "membrane permeability" + "switch peptides", + "membrane permeability", + "cis\/trans", + "cyclic peptide" ], "keywords":[ - "predicted", - "35", - "accuracy", - "containing", - "control", - "structural", - "generation", - "designs", + "membranes", + "designed", + "made", + "permeable", + "alternative", "robustly", - "amide", - "engaged", - "membrane", + "orally", "models", + "generation", + "coupled", + "design", + "structural", + "exposed", + "show", + "principles", + "experimental", + "structures", + "therapeutics", + "cross", + "experimentally", + "amide", + "contribute", + "apparent", + "determined", + "residue", "groups", - "membranes", - "use", - "systematically", - "close", - "wide", "noncanonical", - "experimental", - "nh", - "1", - "permeable", - "designed", - "29", - "orally", - "bioavailability", - "peptides", - "macrocycle", - "84", - "10", "bioavailable", - "range", - "fully", - "experimentally", - "modifications", + "control", + "interactions", "state", - "determined", - "cross", - "made", - "ability", - "hydrogen", - "show", - "design", - "bonding", - "apparent", - "characterization", "macrocycles", - "next", - "structures", - "interactions", - "residue", + "membrane", + "wide", + "modifications", + "macrocycle", "lipid", - "therapeutics", + "achieved", + "internal", + "fully", + "accuracy", + "characterization", + "size", + "next", + "close", + "use", "backbone", - "ensuring", + "permeability", + "29", + "1", + "ability", "high", + "bioavailability", + "hydrogen", + "predicted", "favored", - "size", - "184", - "computational", - "permeability", - "principles", - "achieved", "greater", - "coupled", + "engaged", + "peptides", + "range", + "designs", + "10", "oral", - "alternative", - "internal", - "exposed", - "contribute", + "containing", + "computational", + "ensuring", + "35", + "nh", + "systematically", "isoenergetic", - "investigate" + "investigate", + "184", + "84", + "bonding" ], "release_date":"2022-09-14", "publication":"\"Accurate de novo design of membrane-traversing macrocycles\", Cell, 185, 3520-3532.e26", @@ -515182,89 +517235,89 @@ ], "subtitle":"Solution nmr structure of 9-residue rosetta-designed cyclic peptide d9.16 in cdcl3 with cis\/trans switching (a-tt conformation)", "tags":[ - "switch peptides", - "cis\/trans", + "de novo design", "non natural amino acids", "de novo protein", - "cyclic peptide", - "de novo design", - "membrane permeability" + "switch peptides", + "membrane permeability", + "cis\/trans", + "cyclic peptide" ], "keywords":[ - "predicted", - "35", - "accuracy", - "containing", - "control", - "structural", - "generation", - "designs", + "membranes", + "designed", + "made", + "permeable", + "alternative", "robustly", - "amide", - "engaged", - "membrane", + "orally", "models", + "generation", + "coupled", + "design", + "structural", + "exposed", + "show", + "principles", + "experimental", + "structures", + "therapeutics", + "cross", + "experimentally", + "amide", + "contribute", + "apparent", + "determined", + "residue", "groups", - "membranes", - "use", - "systematically", - "close", - "wide", "noncanonical", - "experimental", - "nh", - "1", - "permeable", - "designed", - "29", - "orally", - "bioavailability", - "peptides", - "macrocycle", - "84", - "10", "bioavailable", - "range", - "fully", - "experimentally", - "modifications", + "control", + "interactions", "state", - "determined", - "cross", - "made", - "ability", - "hydrogen", - "show", - "design", - "bonding", - "apparent", - "characterization", "macrocycles", - "next", - "structures", - "interactions", - "residue", + "membrane", + "wide", + "modifications", + "macrocycle", "lipid", - "therapeutics", + "achieved", + "internal", + "fully", + "accuracy", + "characterization", + "size", + "next", + "close", + "use", "backbone", - "ensuring", + "permeability", + "29", + "1", + "ability", "high", + "bioavailability", + "hydrogen", + "predicted", "favored", - "size", - "184", - "computational", - "permeability", - "principles", - "achieved", "greater", - "coupled", + "engaged", + "peptides", + "range", + "designs", + "10", "oral", - "alternative", - "internal", - "exposed", - "contribute", + "containing", + "computational", + "ensuring", + "35", + "nh", + "systematically", "isoenergetic", - "investigate" + "investigate", + "184", + "84", + "bonding" ], "release_date":"2022-09-14", "publication":"\"Accurate de novo design of membrane-traversing macrocycles\", Cell, 185, 3520-3532.e26", @@ -515452,89 +517505,89 @@ ], "subtitle":"Solution nmr structure of 8-residue rosetta-designed cyclic peptide d8.31 in cdcl3 with cis\/trans switching", "tags":[ - "switch peptides", - "cis\/trans", + "de novo design", "non natural amino acids", "de novo protein", - "cyclic peptide", - "de novo design", - "membrane permeability" + "switch peptides", + "membrane permeability", + "cis\/trans", + "cyclic peptide" ], "keywords":[ - "predicted", - "35", - "accuracy", - "containing", - "control", - "structural", - "generation", - "designs", + "membranes", + "designed", + "made", + "permeable", + "alternative", "robustly", - "amide", - "engaged", - "membrane", + "orally", "models", + "generation", + "coupled", + "design", + "structural", + "exposed", + "show", + "principles", + "experimental", + "structures", + "therapeutics", + "cross", + "experimentally", + "amide", + "contribute", + "apparent", + "determined", + "residue", "groups", - "membranes", - "use", - "systematically", - "close", - "wide", "noncanonical", - "experimental", - "nh", - "1", - "permeable", - "designed", - "29", - "orally", - "bioavailability", - "peptides", - "macrocycle", - "84", - "10", "bioavailable", - "range", - "fully", - "experimentally", - "modifications", + "control", + "interactions", "state", - "determined", - "cross", - "made", - "ability", - "hydrogen", - "show", - "design", - "bonding", - "apparent", - "characterization", "macrocycles", - "next", - "structures", - "interactions", - "residue", + "membrane", + "wide", + "modifications", + "macrocycle", "lipid", - "therapeutics", + "achieved", + "internal", + "fully", + "accuracy", + "characterization", + "size", + "next", + "close", + "use", "backbone", - "ensuring", + "permeability", + "29", + "1", + "ability", "high", + "bioavailability", + "hydrogen", + "predicted", "favored", - "size", - "184", - "computational", - "permeability", - "principles", - "achieved", "greater", - "coupled", + "engaged", + "peptides", + "range", + "designs", + "10", "oral", - "alternative", - "internal", - "exposed", - "contribute", + "containing", + "computational", + "ensuring", + "35", + "nh", + "systematically", "isoenergetic", - "investigate" + "investigate", + "184", + "84", + "bonding" ], "release_date":"2022-09-14", "publication":"\"Accurate de novo design of membrane-traversing macrocycles\", Cell, 185, 3520-3532.e26", @@ -515721,89 +517774,89 @@ ], "subtitle":"Solution nmr structure of 8-residue rosetta-designed cyclic peptide d8.21 in cdcl3 with cis\/trans switching (tt conformation, 47%)", "tags":[ - "switch peptides", - "cis\/trans", + "de novo design", "non natural amino acids", "de novo protein", - "cyclic peptide", - "de novo design", - "membrane permeability" + "switch peptides", + "membrane permeability", + "cis\/trans", + "cyclic peptide" ], "keywords":[ - "predicted", - "35", - "accuracy", - "containing", - "control", - "structural", - "generation", - "designs", + "membranes", + "designed", + "made", + "permeable", + "alternative", "robustly", - "amide", - "engaged", - "membrane", + "orally", "models", + "generation", + "coupled", + "design", + "structural", + "exposed", + "show", + "principles", + "experimental", + "structures", + "therapeutics", + "cross", + "experimentally", + "amide", + "contribute", + "apparent", + "determined", + "residue", "groups", - "membranes", - "use", - "systematically", - "close", - "wide", "noncanonical", - "experimental", - "nh", - "1", - "permeable", - "designed", - "29", - "orally", - "bioavailability", - "peptides", - "macrocycle", - "84", - "10", "bioavailable", - "range", - "fully", - "experimentally", - "modifications", + "control", + "interactions", "state", - "determined", - "cross", - "made", - "ability", - "hydrogen", - "show", - "design", - "bonding", - "apparent", - "characterization", "macrocycles", - "next", - "structures", - "interactions", - "residue", + "membrane", + "wide", + "modifications", + "macrocycle", "lipid", - "therapeutics", + "achieved", + "internal", + "fully", + "accuracy", + "characterization", + "size", + "next", + "close", + "use", "backbone", - "ensuring", + "permeability", + "29", + "1", + "ability", "high", + "bioavailability", + "hydrogen", + "predicted", "favored", - "size", - "184", - "computational", - "permeability", - "principles", - "achieved", "greater", - "coupled", + "engaged", + "peptides", + "range", + "designs", + "10", "oral", - "alternative", - "internal", - "exposed", - "contribute", + "containing", + "computational", + "ensuring", + "35", + "nh", + "systematically", "isoenergetic", - "investigate" + "investigate", + "184", + "84", + "bonding" ], "release_date":"2022-09-14", "publication":"\"Accurate de novo design of membrane-traversing macrocycles\", Cell, 185, 3520-3532.e26", @@ -515990,85 +518043,85 @@ ], "subtitle":"Computationally designed macrocycle", "tags":[ - "cyclic peptide", "de novo protein", - "d8.3.p2" + "d8.3.p2", + "cyclic peptide" ], "keywords":[ - "predicted", - "35", - "accuracy", - "containing", - "control", - "structural", - "generation", - "designs", + "membranes", + "designed", + "made", + "permeable", + "alternative", "robustly", - "amide", - "engaged", - "membrane", + "orally", "models", + "generation", + "coupled", + "design", + "structural", + "exposed", + "show", + "principles", + "experimental", + "structures", + "therapeutics", + "cross", + "experimentally", + "amide", + "contribute", + "apparent", + "determined", + "residue", "groups", - "membranes", - "use", - "systematically", - "close", - "wide", "noncanonical", - "experimental", - "nh", - "1", - "permeable", - "designed", - "29", - "orally", - "bioavailability", - "peptides", - "macrocycle", - "84", - "10", "bioavailable", - "range", - "fully", - "experimentally", - "modifications", + "control", + "interactions", "state", - "determined", - "cross", - "made", - "ability", - "hydrogen", - "show", - "design", - "bonding", - "apparent", - "characterization", "macrocycles", - "next", - "structures", - "interactions", - "residue", + "membrane", + "wide", + "modifications", + "macrocycle", "lipid", - "therapeutics", + "achieved", + "internal", + "fully", + "accuracy", + "characterization", + "size", + "next", + "close", + "use", "backbone", - "ensuring", + "permeability", + "29", + "1", + "ability", "high", + "bioavailability", + "hydrogen", + "predicted", "favored", - "size", - "184", - "computational", - "permeability", - "principles", - "achieved", "greater", - "coupled", + "engaged", + "peptides", + "range", + "designs", + "10", "oral", - "alternative", - "internal", - "exposed", - "contribute", + "containing", + "computational", + "ensuring", + "35", + "nh", + "systematically", "isoenergetic", - "investigate" + "investigate", + "184", + "84", + "bonding" ], "release_date":"2022-09-14", "publication":"\"Accurate de novo design of membrane-traversing macrocycles\", Cell, 185, 3520-3532.e26", @@ -516243,96 +518296,96 @@ ], "subtitle":"Crystal structure of designed helical repeat protein rpb_pew3_r4 bound to pawx4 peptide", "tags":[ - "designed helical repeat protein", - "synthetic protein", "de novo protein", - "peptide binder" + "peptide binder", + "designed helical repeat protein", + "synthetic protein" ], "keywords":[ - "specificity", - "must", - "use", - "bonds", + "made", + "polyproline", + "repeats", + "defined", + "individual", + "optimized", + "hyperstable", + "repeat", + "proteomics", + "side", + "folding", + "protein", + "six", + "correspondence", + "binding", + "vitro", + "general", "tripeptide", - "peptide", - "including", - "designed", + "cells", + "systems", "crystal", + "chains", + "ladders", "geometric", - "ii", - "sequences", - "regions", - "synthetic", - "bind", - "interactions", - "designing", - "repeating", - "repeat", + "remainder", "however", "backbones", - "conformations", - "utility", - "interfaces", - "general", - "ladders", - "proteins", - "hashing", - "proteomics", - "vitro", - "made", - "picomolar", - "units", - "living", - "nanomolar", - "structures", - "individual", + "specificity", + "inspired", + "bidentate", + "targets", + "polar", "buried", - "remainder", - "natural", - "disordered", - "native", - "biology", + "bind", + "proteins", "achieved", - "polyproline", - "systems", + "use", + "units", + "tandem", "hydrogen", - "defined", "four", - "identify", - "challenging", - "would", - "tandem", - "isolation", - "redesigning", - "approaches", - "six", - "compatible", + "nanomolar", + "regions", + "including", + "peptide", + "set", "12", + "designing", + "challenging", "design", - "sequence", - "repeats", - "cells", - "correspondence", - "chains", + "must", + "living", + "hashing", + "biology", + "natural", + "different", + "bonds", "groups", - "optimized", + "disordered", "wide", + "utility", + "backbone", + "sequence", "peptides", - "different", "reveal", - "affinities", - "bidentate", + "designed", + "sequences", + "interfaces", + "repeating", + "structures", + "approaches", + "synthetic", + "interactions", + "compatible", + "redesigning", + "would", + "identify", + "isolation", + "native", + "picomolar", + "conformations", "arrangements", - "polar", - "set", - "protein", - "targets", - "backbone", - "hyperstable", - "inspired", - "side", - "folding", - "binding" + "affinities", + "ii" ], "release_date":"2023-03-22", "publication":"\"De novo design of modular peptide-binding proteins by superhelical matching\", Nature, 616, 581-589", @@ -516369,11 +518422,11 @@ }, { "sim":113.0, - "partner":"7udm" + "partner":"7udn" }, { "sim":113.0, - "partner":"7udn" + "partner":"7udm" }, { "sim":97.0, @@ -516538,95 +518591,95 @@ ], "subtitle":"Crystal structure of designed helical repeat protein rpb_lrp2_r4 bound to lrpx4 peptide", "tags":[ - "peptide binding", "de novo protein", + "peptide binding", "designed helical repeat (dhr)" ], "keywords":[ - "specificity", - "must", - "use", - "bonds", + "made", + "polyproline", + "repeats", + "defined", + "individual", + "optimized", + "hyperstable", + "repeat", + "proteomics", + "side", + "folding", + "protein", + "six", + "correspondence", + "binding", + "vitro", + "general", "tripeptide", - "peptide", - "including", - "designed", + "cells", + "systems", "crystal", + "chains", + "ladders", "geometric", - "ii", - "sequences", - "regions", - "synthetic", - "bind", - "interactions", - "designing", - "repeating", - "repeat", + "remainder", "however", "backbones", - "conformations", - "utility", - "interfaces", - "general", - "ladders", - "proteins", - "hashing", - "proteomics", - "vitro", - "made", - "picomolar", - "units", - "living", - "nanomolar", - "structures", - "individual", + "specificity", + "inspired", + "bidentate", + "targets", + "polar", "buried", - "remainder", - "natural", - "disordered", - "native", - "biology", + "bind", + "proteins", "achieved", - "polyproline", - "systems", + "use", + "units", + "tandem", "hydrogen", - "defined", "four", - "identify", - "challenging", - "would", - "tandem", - "isolation", - "redesigning", - "approaches", - "six", - "compatible", + "nanomolar", + "regions", + "including", + "peptide", + "set", "12", + "designing", + "challenging", "design", - "sequence", - "repeats", - "cells", - "correspondence", - "chains", + "must", + "living", + "hashing", + "biology", + "natural", + "different", + "bonds", "groups", - "optimized", + "disordered", "wide", + "utility", + "backbone", + "sequence", "peptides", - "different", "reveal", - "affinities", - "bidentate", + "designed", + "sequences", + "interfaces", + "repeating", + "structures", + "approaches", + "synthetic", + "interactions", + "compatible", + "redesigning", + "would", + "identify", + "isolation", + "native", + "picomolar", + "conformations", "arrangements", - "polar", - "set", - "protein", - "targets", - "backbone", - "hyperstable", - "inspired", - "side", - "folding", - "binding" + "affinities", + "ii" ], "release_date":"2023-03-22", "publication":"\"De novo design of modular peptide-binding proteins by superhelical matching\", Nature, 616, 581-589", @@ -516810,95 +518863,95 @@ ], "subtitle":"Crystal structure of designed helical repeat protein rpb_plp1_r6 bound to plpx6 peptide", "tags":[ - "peptide binding", "de novo protein", + "peptide binding", "designed helical repeat (dhr)" ], "keywords":[ - "specificity", - "must", - "use", - "bonds", + "made", + "polyproline", + "repeats", + "defined", + "individual", + "optimized", + "hyperstable", + "repeat", + "proteomics", + "side", + "folding", + "protein", + "six", + "correspondence", + "binding", + "vitro", + "general", "tripeptide", - "peptide", - "including", - "designed", + "cells", + "systems", "crystal", + "chains", + "ladders", "geometric", - "ii", - "sequences", - "regions", - "synthetic", - "bind", - "interactions", - "designing", - "repeating", - "repeat", + "remainder", "however", "backbones", - "conformations", - "utility", - "interfaces", - "general", - "ladders", - "proteins", - "hashing", - "proteomics", - "vitro", - "made", - "picomolar", - "units", - "living", - "nanomolar", - "structures", - "individual", + "specificity", + "inspired", + "bidentate", + "targets", + "polar", "buried", - "remainder", - "natural", - "disordered", - "native", - "biology", + "bind", + "proteins", "achieved", - "polyproline", - "systems", + "use", + "units", + "tandem", "hydrogen", - "defined", "four", - "identify", - "challenging", - "would", - "tandem", - "isolation", - "redesigning", - "approaches", - "six", - "compatible", + "nanomolar", + "regions", + "including", + "peptide", + "set", "12", + "designing", + "challenging", "design", - "sequence", - "repeats", - "cells", - "correspondence", - "chains", + "must", + "living", + "hashing", + "biology", + "natural", + "different", + "bonds", "groups", - "optimized", + "disordered", "wide", + "utility", + "backbone", + "sequence", "peptides", - "different", "reveal", - "affinities", - "bidentate", + "designed", + "sequences", + "interfaces", + "repeating", + "structures", + "approaches", + "synthetic", + "interactions", + "compatible", + "redesigning", + "would", + "identify", + "isolation", + "native", + "picomolar", + "conformations", "arrangements", - "polar", - "set", - "protein", - "targets", - "backbone", - "hyperstable", - "inspired", - "side", - "folding", - "binding" + "affinities", + "ii" ], "release_date":"2023-03-22", "publication":"\"De novo design of modular peptide-binding proteins by superhelical matching\", Nature, 616, 581-589", @@ -516931,11 +518984,11 @@ "seq_thr_sim_designed":[ { "sim":514.0, - "partner":"7udm" + "partner":"7udn" }, { "sim":514.0, - "partner":"7udn" + "partner":"7udm" }, { "sim":106.0, @@ -516957,7 +519010,7 @@ ], "seq_max_sim_designed":{ "sim":514.0, - "partner":"7udm" + "partner":"7udn" }, "seq_max_sim_natural":[ @@ -517091,95 +519144,95 @@ ], "subtitle":"Crystal structure of designed helical repeat protein rpb_plp1_r6 in alternative conformation 1 (with peptide)", "tags":[ - "peptide binding", "de novo protein", + "peptide binding", "designed helical repeat (dhr)" ], "keywords":[ - "specificity", - "must", - "use", - "bonds", + "made", + "polyproline", + "repeats", + "defined", + "individual", + "optimized", + "hyperstable", + "repeat", + "proteomics", + "side", + "folding", + "protein", + "six", + "correspondence", + "binding", + "vitro", + "general", "tripeptide", - "peptide", - "including", - "designed", + "cells", + "systems", "crystal", + "chains", + "ladders", "geometric", - "ii", - "sequences", - "regions", - "synthetic", - "bind", - "interactions", - "designing", - "repeating", - "repeat", + "remainder", "however", "backbones", - "conformations", - "utility", - "interfaces", - "general", - "ladders", - "proteins", - "hashing", - "proteomics", - "vitro", - "made", - "picomolar", - "units", - "living", - "nanomolar", - "structures", - "individual", + "specificity", + "inspired", + "bidentate", + "targets", + "polar", "buried", - "remainder", - "natural", - "disordered", - "native", - "biology", + "bind", + "proteins", "achieved", - "polyproline", - "systems", + "use", + "units", + "tandem", "hydrogen", - "defined", "four", - "identify", - "challenging", - "would", - "tandem", - "isolation", - "redesigning", - "approaches", - "six", - "compatible", + "nanomolar", + "regions", + "including", + "peptide", + "set", "12", + "designing", + "challenging", "design", - "sequence", - "repeats", - "cells", - "correspondence", - "chains", + "must", + "living", + "hashing", + "biology", + "natural", + "different", + "bonds", "groups", - "optimized", + "disordered", "wide", + "utility", + "backbone", + "sequence", "peptides", - "different", "reveal", - "affinities", - "bidentate", + "designed", + "sequences", + "interfaces", + "repeating", + "structures", + "approaches", + "synthetic", + "interactions", + "compatible", + "redesigning", + "would", + "identify", + "isolation", + "native", + "picomolar", + "conformations", "arrangements", - "polar", - "set", - "protein", - "targets", - "backbone", - "hyperstable", - "inspired", - "side", - "folding", - "binding" + "affinities", + "ii" ], "release_date":"2023-03-22", "publication":"\"De novo design of modular peptide-binding proteins by superhelical matching\", Nature, 616, 581-589", @@ -517367,95 +519420,95 @@ ], "subtitle":"Crystal structure of designed helical repeat protein rpb_plp1_r6 in alternative conformation 2", "tags":[ - "peptide binding", "de novo protein", + "peptide binding", "designed helical repeat (dhr)" ], "keywords":[ - "specificity", - "must", - "use", - "bonds", + "made", + "polyproline", + "repeats", + "defined", + "individual", + "optimized", + "hyperstable", + "repeat", + "proteomics", + "side", + "folding", + "protein", + "six", + "correspondence", + "binding", + "vitro", + "general", "tripeptide", - "peptide", - "including", - "designed", + "cells", + "systems", "crystal", + "chains", + "ladders", "geometric", - "ii", - "sequences", - "regions", - "synthetic", - "bind", - "interactions", - "designing", - "repeating", - "repeat", + "remainder", "however", "backbones", - "conformations", - "utility", - "interfaces", - "general", - "ladders", - "proteins", - "hashing", - "proteomics", - "vitro", - "made", - "picomolar", - "units", - "living", - "nanomolar", - "structures", - "individual", + "specificity", + "inspired", + "bidentate", + "targets", + "polar", "buried", - "remainder", - "natural", - "disordered", - "native", - "biology", + "bind", + "proteins", "achieved", - "polyproline", - "systems", + "use", + "units", + "tandem", "hydrogen", - "defined", "four", - "identify", - "challenging", - "would", - "tandem", - "isolation", - "redesigning", - "approaches", - "six", - "compatible", + "nanomolar", + "regions", + "including", + "peptide", + "set", "12", + "designing", + "challenging", "design", - "sequence", - "repeats", - "cells", - "correspondence", - "chains", + "must", + "living", + "hashing", + "biology", + "natural", + "different", + "bonds", "groups", - "optimized", + "disordered", "wide", + "utility", + "backbone", + "sequence", "peptides", - "different", "reveal", - "affinities", - "bidentate", + "designed", + "sequences", + "interfaces", + "repeating", + "structures", + "approaches", + "synthetic", + "interactions", + "compatible", + "redesigning", + "would", + "identify", + "isolation", + "native", + "picomolar", + "conformations", "arrangements", - "polar", - "set", - "protein", - "targets", - "backbone", - "hyperstable", - "inspired", - "side", - "folding", - "binding" + "affinities", + "ii" ], "release_date":"2023-03-22", "publication":"\"De novo design of modular peptide-binding proteins by superhelical matching\", Nature, 616, 581-589", @@ -517640,95 +519693,95 @@ ], "subtitle":"Crystal structure of designed helical repeat protein rpb_lrp2_r4 (proteolysis fragment?), forming pseudopolymeric filaments", "tags":[ - "peptide binding", "de novo protein", + "peptide binding", "designed helical repeat (dhr)" ], "keywords":[ - "specificity", - "must", - "use", - "bonds", + "made", + "polyproline", + "repeats", + "defined", + "individual", + "optimized", + "hyperstable", + "repeat", + "proteomics", + "side", + "folding", + "protein", + "six", + "correspondence", + "binding", + "vitro", + "general", "tripeptide", - "peptide", - "including", - "designed", + "cells", + "systems", "crystal", + "chains", + "ladders", "geometric", - "ii", - "sequences", - "regions", - "synthetic", - "bind", - "interactions", - "designing", - "repeating", - "repeat", + "remainder", "however", "backbones", - "conformations", - "utility", - "interfaces", - "general", - "ladders", - "proteins", - "hashing", - "proteomics", - "vitro", - "made", - "picomolar", - "units", - "living", - "nanomolar", - "structures", - "individual", + "specificity", + "inspired", + "bidentate", + "targets", + "polar", "buried", - "remainder", - "natural", - "disordered", - "native", - "biology", + "bind", + "proteins", "achieved", - "polyproline", - "systems", + "use", + "units", + "tandem", "hydrogen", - "defined", "four", - "identify", - "challenging", - "would", - "tandem", - "isolation", - "redesigning", - "approaches", - "six", - "compatible", + "nanomolar", + "regions", + "including", + "peptide", + "set", "12", + "designing", + "challenging", "design", - "sequence", - "repeats", - "cells", - "correspondence", - "chains", + "must", + "living", + "hashing", + "biology", + "natural", + "different", + "bonds", "groups", - "optimized", + "disordered", "wide", + "utility", + "backbone", + "sequence", "peptides", - "different", "reveal", - "affinities", - "bidentate", + "designed", + "sequences", + "interfaces", + "repeating", + "structures", + "approaches", + "synthetic", + "interactions", + "compatible", + "redesigning", + "would", + "identify", + "isolation", + "native", + "picomolar", + "conformations", "arrangements", - "polar", - "set", - "protein", - "targets", - "backbone", - "hyperstable", - "inspired", - "side", - "folding", - "binding" + "affinities", + "ii" ], "release_date":"2023-03-22", "publication":"\"De novo design of modular peptide-binding proteins by superhelical matching\", Nature, 616, 581-589", @@ -517860,84 +519913,84 @@ ], "subtitle":"Designed pentameric proton channel llql", "tags":[ - "proton transport", "membrane protein", + "proton transport", "de novo designed", "pentameric" ], "keywords":[ - "conduction", - "least", - "wire", - "conduct", - "chains", - "molecular", - "channels", - "hypothesize", - "proteins", - "viral", - "somewhat", - "studies", - "similar", - "stable", - "h", - "interrupted", - "apolar", - "along", - "hypothesis", - "minimalist", - "surprisingly", - "6", - "test", - "inferred", + "flickering", "designed", - "presence", - "10", - "highly", - "rates", - "capable", - "static", - "stretches", + "correlated", "simulations", - "pathways", - "spots", - "materials", "engineering", - "gradients", "often", - "polar", + "molecular", "wires", - "proton", - "selective", - "dynamics", - "forming", - "transient", "design", - "structures", - "protein", - "flickering", - "using", - "inform", - "interspersed", - "transport", + "h", "mechanisms", - "pockets", - "segments", - "essential", "water", - "na", - "conducted", - "biological", - "protons", - "dry", + "spots", + "transport", + "6", + "interrupted", "transmembrane", + "inferred", + "rates", + "principles", + "structures", "excess", - "cells", + "static", + "conducted", + "apolar", "side", - "correlated", - "principles", + "presence", + "performed", + "biological", + "selective", + "inform", + "wire", + "polar", + "conduction", + "transient", + "na", + "hypothesize", + "least", + "protein", + "gradients", + "pockets", + "proteins", + "stretches", + "capable", "molecules", - "performed" + "proton", + "viral", + "conduct", + "essential", + "segments", + "minimalist", + "cells", + "test", + "interspersed", + "highly", + "dry", + "channels", + "along", + "studies", + "stable", + "somewhat", + "chains", + "pathways", + "10", + "materials", + "hypothesis", + "using", + "protons", + "similar", + "forming", + "dynamics", + "surprisingly" ], "release_date":"2022-04-06", "publication":"\"Transient water wires mediate selective proton transport in designed channel proteins\", Nat.Chem., 15, 1012-1021", @@ -517974,6 +520027,10 @@ ], "struct_thr_sim_designed":[ + { + "sim":1.0, + "partner":"7udz" + }, { "sim":1.0, "partner":"7udx" @@ -517988,7 +520045,7 @@ }, { "sim":1.0, - "partner":"7udz" + "partner":"6mct" }, { "sim":1.0, @@ -517998,10 +520055,6 @@ "sim":1.0, "partner":"7udw" }, - { - "sim":1.0, - "partner":"6mct" - }, { "sim":0.970600009, "partner":"6mqu" @@ -518019,7 +520072,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"7udx" + "partner":"7udz" }, "struct_max_sim_natural":[ @@ -518093,84 +520146,84 @@ ], "subtitle":"Designed pentameric proton channel qqll", "tags":[ - "proton transport", "membrane protein", + "proton transport", "de novo designed", "pentameric" ], "keywords":[ - "conduction", - "least", - "wire", - "conduct", - "chains", - "molecular", - "channels", - "hypothesize", - "proteins", - "viral", - "somewhat", - "studies", - "similar", - "stable", - "h", - "interrupted", - "apolar", - "along", - "hypothesis", - "minimalist", - "surprisingly", - "6", - "test", - "inferred", + "flickering", "designed", - "presence", - "10", - "highly", - "rates", - "capable", - "static", - "stretches", + "correlated", "simulations", - "pathways", - "spots", - "materials", "engineering", - "gradients", "often", - "polar", + "molecular", "wires", - "proton", - "selective", - "dynamics", - "forming", - "transient", "design", - "structures", - "protein", - "flickering", - "using", - "inform", - "interspersed", - "transport", + "h", "mechanisms", - "pockets", - "segments", - "essential", "water", - "na", - "conducted", - "biological", - "protons", - "dry", + "spots", + "transport", + "6", + "interrupted", "transmembrane", + "inferred", + "rates", + "principles", + "structures", "excess", - "cells", + "static", + "conducted", + "apolar", "side", - "correlated", - "principles", + "presence", + "performed", + "biological", + "selective", + "inform", + "wire", + "polar", + "conduction", + "transient", + "na", + "hypothesize", + "least", + "protein", + "gradients", + "pockets", + "proteins", + "stretches", + "capable", "molecules", - "performed" + "proton", + "viral", + "conduct", + "essential", + "segments", + "minimalist", + "cells", + "test", + "interspersed", + "highly", + "dry", + "channels", + "along", + "studies", + "stable", + "somewhat", + "chains", + "pathways", + "10", + "materials", + "hypothesis", + "using", + "protons", + "similar", + "forming", + "dynamics", + "surprisingly" ], "release_date":"2022-04-06", "publication":"\"Transient water wires mediate selective proton transport in designed channel proteins\", Nat.Chem., 15, 1012-1021", @@ -518245,7 +520298,7 @@ ], "seq_max_sim_designed":{ "sim":42.0, - "partner":"7udz" + "partner":"7udx" }, "seq_max_sim_natural":[ @@ -518326,84 +520379,84 @@ ], "subtitle":"Designed pentameric proton channel qlql", "tags":[ - "proton transport", "membrane protein", + "proton transport", "de novo designed", "pentameric" ], "keywords":[ - "conduction", - "least", - "wire", - "conduct", - "chains", - "molecular", - "channels", - "hypothesize", - "proteins", - "viral", - "somewhat", - "studies", - "similar", - "stable", - "h", - "interrupted", - "apolar", - "along", - "hypothesis", - "minimalist", - "surprisingly", - "6", - "test", - "inferred", + "flickering", "designed", - "presence", - "10", - "highly", - "rates", - "capable", - "static", - "stretches", + "correlated", "simulations", - "pathways", - "spots", - "materials", "engineering", - "gradients", "often", - "polar", + "molecular", "wires", - "proton", - "selective", - "dynamics", - "forming", - "transient", "design", - "structures", - "protein", - "flickering", - "using", - "inform", - "interspersed", - "transport", + "h", "mechanisms", - "pockets", - "segments", - "essential", "water", - "na", - "conducted", - "biological", - "protons", - "dry", + "spots", + "transport", + "6", + "interrupted", "transmembrane", + "inferred", + "rates", + "principles", + "structures", "excess", - "cells", + "static", + "conducted", + "apolar", "side", - "correlated", - "principles", + "presence", + "performed", + "biological", + "selective", + "inform", + "wire", + "polar", + "conduction", + "transient", + "na", + "hypothesize", + "least", + "protein", + "gradients", + "pockets", + "proteins", + "stretches", + "capable", "molecules", - "performed" + "proton", + "viral", + "conduct", + "essential", + "segments", + "minimalist", + "cells", + "test", + "interspersed", + "highly", + "dry", + "channels", + "along", + "studies", + "stable", + "somewhat", + "chains", + "pathways", + "10", + "materials", + "hypothesis", + "using", + "protons", + "similar", + "forming", + "dynamics", + "surprisingly" ], "release_date":"2022-04-06", "publication":"\"Transient water wires mediate selective proton transport in designed channel proteins\", Nat.Chem., 15, 1012-1021", @@ -518446,7 +520499,7 @@ }, { "sim":1.0, - "partner":"6mpw" + "partner":"7udw" }, { "sim":1.0, @@ -518454,11 +520507,11 @@ }, { "sim":1.0, - "partner":"6mq2" + "partner":"6mpw" }, { "sim":1.0, - "partner":"7udw" + "partner":"6mq2" }, { "sim":1.0, @@ -518478,7 +520531,7 @@ ], "seq_max_sim_designed":{ "sim":42.0, - "partner":"7udw" + "partner":"7udv" }, "seq_max_sim_natural":[ @@ -518559,84 +520612,84 @@ ], "subtitle":"Designed pentameric channel qlll", "tags":[ - "proton transport", "membrane protein", + "proton transport", "de novo designed", "pentameric" ], "keywords":[ - "conduction", - "least", - "wire", - "conduct", - "chains", - "molecular", - "channels", - "hypothesize", - "proteins", - "viral", - "somewhat", - "studies", - "similar", - "stable", - "h", - "interrupted", - "apolar", - "along", - "hypothesis", - "minimalist", - "surprisingly", - "6", - "test", - "inferred", + "flickering", "designed", - "presence", - "10", - "highly", - "rates", - "capable", - "static", - "stretches", + "correlated", "simulations", - "pathways", - "spots", - "materials", "engineering", - "gradients", "often", - "polar", + "molecular", "wires", - "proton", - "selective", - "dynamics", - "forming", - "transient", "design", - "structures", - "protein", - "flickering", - "using", - "inform", - "interspersed", - "transport", + "h", "mechanisms", - "pockets", - "segments", - "essential", "water", - "na", - "conducted", - "biological", - "protons", - "dry", + "spots", + "transport", + "6", + "interrupted", "transmembrane", + "inferred", + "rates", + "principles", + "structures", "excess", - "cells", + "static", + "conducted", + "apolar", "side", - "correlated", - "principles", + "presence", + "performed", + "biological", + "selective", + "inform", + "wire", + "polar", + "conduction", + "transient", + "na", + "hypothesize", + "least", + "protein", + "gradients", + "pockets", + "proteins", + "stretches", + "capable", "molecules", - "performed" + "proton", + "viral", + "conduct", + "essential", + "segments", + "minimalist", + "cells", + "test", + "interspersed", + "highly", + "dry", + "channels", + "along", + "studies", + "stable", + "somewhat", + "chains", + "pathways", + "10", + "materials", + "hypothesis", + "using", + "protons", + "similar", + "forming", + "dynamics", + "surprisingly" ], "release_date":"2022-04-06", "publication":"\"Transient water wires mediate selective proton transport in designed channel proteins\", Nat.Chem., 15, 1012-1021", @@ -518675,15 +520728,15 @@ "struct_thr_sim_designed":[ { "sim":1.0, - "partner":"7udz" + "partner":"6mq2" }, { "sim":1.0, - "partner":"7udx" + "partner":"7udw" }, { "sim":1.0, - "partner":"7udw" + "partner":"6mct" }, { "sim":1.0, @@ -518691,19 +520744,19 @@ }, { "sim":1.0, - "partner":"6mq2" + "partner":"7udv" }, { - "sim":1.0, - "partner":"7udv" + "sim":0.9690999985, + "partner":"6mqu" }, { "sim":1.0, - "partner":"6mct" + "partner":"7udx" }, { - "sim":0.9690999985, - "partner":"6mqu" + "sim":1.0, + "partner":"7udz" } ], "struct_thr_sim_natural":[ @@ -518711,14 +520764,14 @@ ], "seq_max_sim_designed":{ "sim":44.0, - "partner":"7udw" + "partner":"7udx" }, "seq_max_sim_natural":[ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"7udz" + "partner":"6mq2" }, "struct_max_sim_natural":[ @@ -518792,84 +520845,84 @@ ], "subtitle":"Designed pentameric proton channel lqll", "tags":[ - "proton transport", "membrane protein", + "proton transport", "de novo designed", "pentameric" ], "keywords":[ - "conduction", - "least", - "wire", - "conduct", - "chains", - "molecular", - "channels", - "hypothesize", - "proteins", - "viral", - "somewhat", - "studies", - "similar", - "stable", - "h", - "interrupted", - "apolar", - "along", - "hypothesis", - "minimalist", - "surprisingly", - "6", - "test", - "inferred", + "flickering", "designed", - "presence", - "10", - "highly", - "rates", - "capable", - "static", - "stretches", + "correlated", "simulations", - "pathways", - "spots", - "materials", "engineering", - "gradients", "often", - "polar", + "molecular", "wires", - "proton", - "selective", - "dynamics", - "forming", - "transient", "design", - "structures", - "protein", - "flickering", - "using", - "inform", - "interspersed", - "transport", + "h", "mechanisms", - "pockets", - "segments", - "essential", "water", - "na", - "conducted", - "biological", - "protons", - "dry", + "spots", + "transport", + "6", + "interrupted", "transmembrane", + "inferred", + "rates", + "principles", + "structures", "excess", - "cells", + "static", + "conducted", + "apolar", "side", - "correlated", - "principles", + "presence", + "performed", + "biological", + "selective", + "inform", + "wire", + "polar", + "conduction", + "transient", + "na", + "hypothesize", + "least", + "protein", + "gradients", + "pockets", + "proteins", + "stretches", + "capable", "molecules", - "performed" + "proton", + "viral", + "conduct", + "essential", + "segments", + "minimalist", + "cells", + "test", + "interspersed", + "highly", + "dry", + "channels", + "along", + "studies", + "stable", + "somewhat", + "chains", + "pathways", + "10", + "materials", + "hypothesis", + "using", + "protons", + "similar", + "forming", + "dynamics", + "surprisingly" ], "release_date":"2022-04-06", "publication":"\"Transient water wires mediate selective proton transport in designed channel proteins\", Nat.Chem., 15, 1012-1021", @@ -518906,6 +520959,10 @@ ], "struct_thr_sim_designed":[ + { + "sim":1.0, + "partner":"7udv" + }, { "sim":1.0, "partner":"7udw" @@ -518920,7 +520977,7 @@ }, { "sim":1.0, - "partner":"7udv" + "partner":"6mct" }, { "sim":1.0, @@ -518930,10 +520987,6 @@ "sim":1.0, "partner":"7udx" }, - { - "sim":1.0, - "partner":"6mct" - }, { "sim":0.9690999985, "partner":"6mqu" @@ -518951,7 +521004,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"6mpw" + "partner":"7udv" }, "struct_max_sim_natural":[ @@ -519077,94 +521130,94 @@ ], "subtitle":"Crystal structure of designed helical repeat protein rpb_plp3_r6 bound to plpx6 peptide", "tags":[ - "peptide binding", - "de novo protein" + "de novo protein", + "peptide binding" ], "keywords":[ - "specificity", - "must", - "use", - "bonds", + "made", + "polyproline", + "repeats", + "defined", + "individual", + "optimized", + "hyperstable", + "repeat", + "proteomics", + "side", + "folding", + "protein", + "six", + "correspondence", + "binding", + "vitro", + "general", "tripeptide", - "peptide", - "including", - "designed", + "cells", + "systems", "crystal", + "chains", + "ladders", "geometric", - "ii", - "sequences", - "regions", - "synthetic", - "bind", - "interactions", - "designing", - "repeating", - "repeat", + "remainder", "however", "backbones", - "conformations", - "utility", - "interfaces", - "general", - "ladders", - "proteins", - "hashing", - "proteomics", - "vitro", - "made", - "picomolar", - "units", - "living", - "nanomolar", - "structures", - "individual", + "specificity", + "inspired", + "bidentate", + "targets", + "polar", "buried", - "remainder", - "natural", - "disordered", - "native", - "biology", + "bind", + "proteins", "achieved", - "polyproline", - "systems", + "use", + "units", + "tandem", "hydrogen", - "defined", "four", - "identify", - "challenging", - "would", - "tandem", - "isolation", - "redesigning", - "approaches", - "six", - "compatible", + "nanomolar", + "regions", + "including", + "peptide", + "set", "12", + "designing", + "challenging", "design", - "sequence", - "repeats", - "cells", - "correspondence", - "chains", + "must", + "living", + "hashing", + "biology", + "natural", + "different", + "bonds", "groups", - "optimized", + "disordered", "wide", + "utility", + "backbone", + "sequence", "peptides", - "different", "reveal", - "affinities", - "bidentate", + "designed", + "sequences", + "interfaces", + "repeating", + "structures", + "approaches", + "synthetic", + "interactions", + "compatible", + "redesigning", + "would", + "identify", + "isolation", + "native", + "picomolar", + "conformations", "arrangements", - "polar", - "set", - "protein", - "targets", - "backbone", - "hyperstable", - "inspired", - "side", - "folding", - "binding" + "affinities", + "ii" ], "release_date":"2023-03-29", "publication":"\"De novo design of modular peptide-binding proteins by superhelical matching\", Nature, 616, 581-589", @@ -519197,11 +521250,11 @@ "seq_thr_sim_designed":[ { "sim":77.0, - "partner":"7udm" + "partner":"7udn" }, { "sim":77.0, - "partner":"7udn" + "partner":"7udm" }, { "sim":69.0, @@ -519271,7 +521324,7 @@ ], "seq_max_sim_designed":{ "sim":77.0, - "partner":"7udm" + "partner":"7udn" }, "seq_max_sim_natural":[ @@ -519332,112 +521385,112 @@ ], "subtitle":"Crystal structure of a de novo designed ovoid tim barrel ot3", "tags":[ - "oval curvature", + "tim barrel", "de novo protein", - "de novo", - "tim barrel" + "oval curvature", + "de novo" ], "keywords":[ - "hosting", - "represents", - "architecture", + "hydrophobic", + "resolution", + "show", "multiple", - "ablated", - "use", + "core", "strategy", - "temperatures", - "designed", - "mutations", - "towards", - "crystal", - "twofold", - "determined", - "target", - "obtain", - "show", - "enriched", - "sampling", - "sequences", - "robustness", - "structure", + "folding", + "protein", + "finely", + "successfully", + "installation", + "pockets", + "binding", + "proportion", "networks", - "limiting", + "charged", + "novo", "implement", - "ovoid", - "even", - "utility", - "enrichment", - "drawing", - "de", - "prerequisite", - "installation", + "greater", + "major", + "crystal", + "stable", + "temperatures", + "efforts", + "represents", + "overall", + "step", + "twofold", + "residues", + "protocol", "although", - "\u00e5", - "successfully", - "remains", - "highly", + "functions", + "control", "elongated", - "nature", - "step", - "ability", - "bonding", - "alter", - "proportion", "buried", - "charged", - "natural", - "pockets", - "hydrogen", - "alanine", - "drastic", - "control", - "functional", - "report", - "resolution", - "hypothesis", + "sites", "autoregressive", - "active", - "functions", - "protocol", - "finely", - "melting", - "design", + "use", + "architecture", + "hydrogen", + "scaffold", + "highly", + "enrichment", "elusive", - "followed", + "robustness", + "barrel", "iterative", - "core", - "hydrophobic", + "hypothesis", + "ovoid", + "bonding", + "curvature", "symmetry", - "high", - "sequence", - "retaining", - "greater", - "important", - "tim", - "sites", + "design", + "beta", + "sampling", "diverse", - "designs", - "overall", - "barrels", - "novo", - "stable", - "efforts", - "barrel", + "active", + "even", + "functional", + "natural", "fold", - "residues", + "alanine", + "hosting", + "utility", + "backbone", + "ability", + "sequence", + "retaining", + "ablated", + "capacity", "folds", + "enriched", + "obtain", + "designed", "central", - "scaffold", - "protein", - "yield", - "backbone", - "beta", - "curvature", - "major", - "folding", - "binding", + "drastic", + "sequences", + "limiting", "inspiration", - "capacity" + "mutations", + "de", + "drawing", + "remains", + "\u00e5", + "structure", + "important", + "report", + "determined", + "target", + "nature", + "followed", + "yield", + "melting", + "towards", + "high", + "alter", + "prerequisite", + "tim", + "designs", + "barrels" ], "release_date":"2023-01-18", "publication":"\"De Novo Design of a Highly Stable Ovoid TIM Barrel: Unlocking Pocket Shape towards Functional Design\", Biodes Res, 2022, 9842315-9842315", @@ -519550,9 +521603,9 @@ "subtitle":"Cryo-em of ph-controlled and self-assembled fibers, peptide 2", "tags":[ "ph-dependent assembly", - "structural protein", + "peptide nanotube", "self-assemble", - "peptide nanotube" + "structural protein" ], "keywords":[ "description", @@ -519690,129 +521743,129 @@ ], "subtitle":"Stx2a and darpin complex", "tags":[ - "darpin", + "shiga toxin", "antitoxin", - "shiga toxin" + "darpin" ], "keywords":[ - "evolution", - "monomeric", - "nm", - "change", - "represents", - "causing", - "potent", - "concentration", - "stx2a", - "challenge", - "recommended", - "designed", + "finally", + "engineering", + "hemolytic", + "development", + "repeat", + "half", + "subunit", + "via", + "new", + "derives", + "damage", + "model", + "study", + "gut", + "vitro", "syndrome", + "b", + "cells", + "neutralizes", + "kidney", + "major", + "catalytic", + "two", + "uremic", "induced", - "dimeric", - "potential", - "target", - "based", - "gut", - "best", - "supportive", - "interferes", - "repeat", - "novel", - "therapeutic", "subtype", - "proteins", - "maximal", - "neutralizing", - "finally", - "resulting", "binds", - "currently", - "vitro", - "3", - "absorbed", - "stec", - "effective", - "trimeric", + "care", + "presumably", "cause", - "kidney", - "future", - "bloody", - "exhibit", - "attachment", - "created", - "protects", + "stx2", + "conformational", + "action", + "stx2a", + "represents", + "infection", + "50", + "targets", + "fused", + "proteins", + "concentration", + "2", + "ankyrin", + "constituents", "neutralization", + "mice", + "created", + "evolution", + "sd5", + "unprecedented", + "stec", + "future", + "complementary", "inhibits", + "combination", + "1", + "systemically", + "effective", + "distorts", + "best", + "exhibit", + "design", "stx1", - "sd5", - "associated", - "via", + "symmetry", + "potential", + "nm", + "therapeutic", + "attachment", + "recommended", + "mode", + "leading", + "shiga", + "coli", + "common", + "neutralizing", "reveals", + "associated", "pointing", + "causing", + "designed", "hus", - "coli", - "common", - "damage", - "uremic", - "report", - "presumably", - "catalytic", - "derives", - "1", - "fused", - "mode", - "mice", - "infection", - "activity", - "constituents", - "engineering", - "induces", - "design", - "stx2", - "model", - "action", - "symmetry", - "high", - "severe", - "hemolytic", - "cells", - "treatment", + "trimeric", + "directed", + "protects", + "diarrhea", "panel", + "rational", + "maximal", + "3", + "based", + "darpin", + "toxin", + "severe", + "enzymatic", + "interferes", "efficiently", + "monomeric", + "absorbed", + "report", + "resulting", "pathology", - "conformational", - "study", - "neutralizes", - "rational", - "unprecedented", - "systemically", + "target", + "toxicity", "drug", - "directed", - "half", - "enzymatic", - "care", - "ankyrin", + "supportive", + "change", + "high", + "activity", + "potent", + "currently", "ec", - "darpin", + "bloody", + "challenge", "secreted", - "subunit", - "two", - "complementary", - "distorts", - "leading", - "50", - "b", - "toxicity", - "2", - "targets", - "development", - "combination", - "shiga", - "diarrhea", - "major", - "toxin", - "new" + "treatment", + "induces", + "novel", + "dimeric" ], "release_date":"2023-04-12", "publication":"\"A Multi-Specific DARPin Potently Neutralizes Shiga Toxin 2 via Simultaneous Modulation of Both Toxin Subunits\", Bioengineering (Basel), 9", @@ -519869,11 +521922,11 @@ }, { "sim":248.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":248.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":248.0, @@ -519897,19 +521950,19 @@ }, { "sim":243.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":243.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":243.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":243.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":243.0, @@ -519917,35 +521970,35 @@ }, { "sim":243.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":243.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":243.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":243.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":243.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":243.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":243.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":243.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":243.0, @@ -520065,7 +522118,7 @@ }, { "sim":227.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":227.0, @@ -520073,7 +522126,7 @@ }, { "sim":227.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":226.0, @@ -520161,11 +522214,15 @@ }, { "sim":172.0, - "partner":"9f24" + "partner":"8aiw" }, { "sim":172.0, - "partner":"8aiw" + "partner":"9f24" + }, + { + "sim":171.0, + "partner":"9glq" }, { "sim":171.0, @@ -520177,19 +522234,19 @@ }, { "sim":170.0, - "partner":"8rci" + "partner":"7z73" }, { "sim":170.0, - "partner":"7z73" + "partner":"8rci" }, { "sim":170.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":170.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":170.0, @@ -520231,11 +522288,11 @@ }, { "sim":257.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":257.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":256.0, @@ -520331,271 +522388,271 @@ }, { "sim":243.0, - "partner":"5eno" + "partner":"4dx6" }, { "sim":243.0, - "partner":"6zob" + "partner":"6mzf" }, { "sim":243.0, - "partner":"7yz0" + "partner":"6sgs" }, { "sim":243.0, - "partner":"6zo5" + "partner":"6zoc" }, { "sim":243.0, - "partner":"6mzf" + "partner":"6mze" }, { "sim":243.0, - "partner":"4dx6" + "partner":"6zo6" }, { "sim":243.0, - "partner":"6q4n" + "partner":"5enp" }, { "sim":243.0, - "partner":"7yz1" + "partner":"5nqt" }, { "sim":243.0, - "partner":"7z01" + "partner":"7yz2" }, { "sim":243.0, - "partner":"6zoc" + "partner":"7z02" }, { "sim":243.0, - "partner":"5enp" + "partner":"6q4o" }, { "sim":243.0, - "partner":"5nqt" + "partner":"7ac5" }, { "sim":243.0, - "partner":"6sgs" + "partner":"7b8r" }, { "sim":243.0, - "partner":"6mze" + "partner":"6zod" }, { "sim":243.0, - "partner":"6zo6" + "partner":"4dx7" }, { "sim":243.0, - "partner":"7yz2" + "partner":"5nqu" }, { "sim":243.0, - "partner":"7z02" + "partner":"7yz3" }, { "sim":243.0, - "partner":"4dx7" + "partner":"4u95" }, { "sim":243.0, - "partner":"5nqu" + "partner":"6zo7" }, { "sim":243.0, - "partner":"6q4o" + "partner":"6zoe" }, { "sim":243.0, - "partner":"4u95" + "partner":"5enq" }, { "sim":243.0, - "partner":"6zod" + "partner":"6q4p" }, { "sim":243.0, - "partner":"7ac5" + "partner":"6sgt" }, { "sim":243.0, - "partner":"7b8r" + "partner":"7b8s" }, { "sim":243.0, - "partner":"7yz3" + "partner":"7ouk" }, { "sim":243.0, - "partner":"5enq" + "partner":"7yz5" }, { "sim":243.0, - "partner":"6zo7" + "partner":"2j8s" }, { "sim":243.0, - "partner":"6zoe" + "partner":"4u96" }, { "sim":243.0, - "partner":"6q4p" + "partner":"6zo8" }, { "sim":243.0, - "partner":"6sgt" + "partner":"6zof" }, { "sim":243.0, - "partner":"7ouk" + "partner":"7yz6" }, { "sim":243.0, - "partner":"7yz5" + "partner":"4lnu" }, { "sim":243.0, - "partner":"2j8s" + "partner":"6sgu" }, { "sim":243.0, - "partner":"4u96" + "partner":"5enr" }, { "sim":243.0, - "partner":"7b8s" + "partner":"7oul" }, { "sim":243.0, - "partner":"4lnu" + "partner":"4u8v" }, { "sim":243.0, - "partner":"6zo8" + "partner":"7b8t" }, { "sim":243.0, - "partner":"6zof" + "partner":"6zo9" }, { "sim":243.0, - "partner":"7yz6" + "partner":"6zog" }, { "sim":243.0, - "partner":"5enr" + "partner":"5nc5" }, { "sim":243.0, - "partner":"4u8v" + "partner":"6zwb" }, { "sim":243.0, - "partner":"6sgu" + "partner":"4drx" }, { "sim":243.0, - "partner":"7oul" + "partner":"5eib" }, { "sim":243.0, - "partner":"5nc5" + "partner":"5nm5" }, { "sim":243.0, - "partner":"6zo9" + "partner":"7oum" }, { "sim":243.0, - "partner":"6zog" + "partner":"5ens" }, { "sim":243.0, - "partner":"7b8t" + "partner":"4f6r" }, { "sim":243.0, - "partner":"4drx" + "partner":"5en5" }, { "sim":243.0, - "partner":"5eib" + "partner":"6zoa" }, { "sim":243.0, - "partner":"5nm5" + "partner":"6zoh" }, { "sim":243.0, - "partner":"5ens" + "partner":"6zwc" }, { "sim":243.0, - "partner":"6zwb" + "partner":"4u8y" }, { "sim":243.0, - "partner":"7oum" + "partner":"7yyy" }, { "sim":243.0, - "partner":"4f6r" + "partner":"4hna" }, { "sim":243.0, - "partner":"5en5" + "partner":"6sgr" }, { "sim":243.0, - "partner":"4u8y" + "partner":"4c48" }, { "sim":243.0, - "partner":"6zoa" + "partner":"7yyz" }, { "sim":243.0, - "partner":"6zoh" + "partner":"5ent" }, { "sim":243.0, - "partner":"6zwc" + "partner":"5jmn" }, { "sim":243.0, - "partner":"7yyy" + "partner":"6zob" }, { "sim":243.0, - "partner":"4hna" + "partner":"4dx5" }, { "sim":243.0, - "partner":"4c48" + "partner":"5eno" }, { "sim":243.0, - "partner":"5ent" + "partner":"6zo5" }, { "sim":243.0, - "partner":"5jmn" + "partner":"7yz0" }, { "sim":243.0, - "partner":"6sgr" + "partner":"6q4n" }, { "sim":243.0, - "partner":"7yyz" + "partner":"7yz1" }, { "sim":243.0, - "partner":"4dx5" + "partner":"7z01" }, { "sim":243.0, @@ -520607,11 +522664,11 @@ }, { "sim":242.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":242.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":242.0, @@ -520671,11 +522728,11 @@ }, { "sim":238.0, - "partner":"5oyj" + "partner":"3zu7" }, { "sim":238.0, - "partner":"3zu7" + "partner":"5oyj" }, { "sim":238.0, @@ -520791,11 +522848,11 @@ }, { "sim":226.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":226.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":226.0, @@ -520891,11 +522948,11 @@ }, { "sim":209.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":209.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":204.0, @@ -520961,10 +523018,6 @@ "sim":175.0, "partner":"2v4h" }, - { - "sim":175.0, - "partner":"7pd8" - }, { "sim":175.0, "partner":"7pdd" @@ -520977,6 +523030,10 @@ "sim":175.0, "partner":"7pdh" }, + { + "sim":175.0, + "partner":"7pd8" + }, { "sim":173.0, "partner":"7bhe" @@ -521019,23 +523076,23 @@ }, { "sim":141.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":141.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":141.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":141.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":141.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":141.0, @@ -521043,11 +523100,11 @@ }, { "sim":141.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":141.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":141.0, @@ -521093,10 +523150,6 @@ "sim":126.0, "partner":"5y4f" }, - { - "sim":124.0, - "partner":"3aji" - }, { "sim":124.0, "partner":"2dvw" @@ -521107,11 +523160,11 @@ }, { "sim":124.0, - "partner":"5y4e" + "partner":"3aji" }, { - "sim":123.0, - "partner":"5vhj" + "sim":124.0, + "partner":"5y4e" }, { "sim":123.0, @@ -521143,15 +523196,15 @@ }, { "sim":123.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":123.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":123.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":123.0, @@ -521161,6 +523214,10 @@ "sim":123.0, "partner":"7vxw" }, + { + "sim":123.0, + "partner":"1uoh" + }, { "sim":123.0, "partner":"7vy4" @@ -521171,11 +523228,11 @@ }, { "sim":123.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":123.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":123.0, @@ -521347,11 +523404,11 @@ }, { "sim":109.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":109.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":108.0, @@ -521399,24 +523456,16 @@ }, { "sim":104.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":104.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":104.0, "partner":"7roy" }, - { - "sim":103.0, - "partner":"6m11" - }, - { - "sim":103.0, - "partner":"6m12" - }, { "sim":103.0, "partner":"6m13" @@ -521441,6 +523490,14 @@ "sim":103.0, "partner":"4o1p" }, + { + "sim":103.0, + "partner":"6m11" + }, + { + "sim":103.0, + "partner":"6m12" + }, { "sim":103.0, "partner":"7pty" @@ -521485,10 +523542,6 @@ "sim":98.0, "partner":"6jd6" }, - { - "sim":98.0, - "partner":"6v9x" - }, { "sim":98.0, "partner":"6v9y" @@ -521501,6 +523554,10 @@ "sim":98.0, "partner":"6v9w" }, + { + "sim":98.0, + "partner":"6v9x" + }, { "sim":98.0, "partner":"7or0" @@ -521539,15 +523596,15 @@ }, { "sim":95.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":95.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":95.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":95.0, @@ -521683,11 +523740,11 @@ }, { "sim":90.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":90.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":90.0, @@ -521805,10 +523862,6 @@ "sim":78.0, "partner":"5wo6" }, - { - "sim":78.0, - "partner":"5iwr" - }, { "sim":78.0, "partner":"5iwt" @@ -521861,6 +523914,10 @@ "sim":78.0, "partner":"5iwp" }, + { + "sim":78.0, + "partner":"5iwr" + }, { "sim":78.0, "partner":"5wo7" @@ -521883,19 +523940,19 @@ }, { "sim":76.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":76.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":76.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":76.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":75.0, @@ -521913,10 +523970,6 @@ "sim":74.0, "partner":"1d9s" }, - { - "sim":74.0, - "partner":"6o1p" - }, { "sim":74.0, "partner":"6b5v" @@ -521955,7 +524008,7 @@ }, { "sim":74.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":74.0, @@ -521989,6 +524042,10 @@ "sim":74.0, "partner":"7t6l" }, + { + "sim":74.0, + "partner":"7t6m" + }, { "sim":73.0, "partner":"6if3" @@ -522027,15 +524084,15 @@ }, { "sim":67.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":67.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":67.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":67.0, @@ -522069,10 +524126,6 @@ "sim":66.0, "partner":"6emk" }, - { - "sim":65.0, - "partner":"7k4a" - }, { "sim":65.0, "partner":"7k4b" @@ -522095,7 +524148,7 @@ }, { "sim":65.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":65.0, @@ -522111,11 +524164,11 @@ }, { "sim":65.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":65.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":65.0, @@ -522133,6 +524186,10 @@ "sim":65.0, "partner":"6bo8" }, + { + "sim":65.0, + "partner":"6bo9" + }, { "sim":64.0, "partner":"8pef" @@ -522193,10 +524250,6 @@ "sim":60.0, "partner":"5is0" }, - { - "sim":60.0, - "partner":"7mzc" - }, { "sim":60.0, "partner":"7l2v" @@ -522259,7 +524312,7 @@ }, { "sim":60.0, - "partner":"7l2n" + "partner":"7mzc" }, { "sim":60.0, @@ -522295,20 +524348,16 @@ }, { "sim":60.0, - "partner":"7lpd" + "partner":"7l2n" }, { "sim":60.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":60.0, "partner":"7rqv" }, - { - "sim":60.0, - "partner":"7lpe" - }, { "sim":60.0, "partner":"7rqw" @@ -522341,6 +524390,14 @@ "sim":60.0, "partner":"7lpc" }, + { + "sim":60.0, + "partner":"7rqu" + }, + { + "sim":60.0, + "partner":"7lpd" + }, { "sim":59.0, "partner":"6l93" @@ -522349,6 +524406,10 @@ "sim":59.0, "partner":"3ljn" }, + { + "sim":58.0, + "partner":"8ycp" + }, { "sim":58.0, "partner":"7lqy" @@ -522403,11 +524464,11 @@ }, { "sim":53.0, - "partner":"2eta" + "partner":"2etb" }, { "sim":53.0, - "partner":"2etb" + "partner":"2eta" }, { "sim":53.0, @@ -522421,10 +524482,6 @@ "sim":53.0, "partner":"6bo4" }, - { - "sim":53.0, - "partner":"6u86" - }, { "sim":53.0, "partner":"6u88" @@ -522459,11 +524516,11 @@ }, { "sim":53.0, - "partner":"5hi9" + "partner":"6u86" }, { "sim":53.0, - "partner":"7zji" + "partner":"5hi9" }, { "sim":53.0, @@ -522481,6 +524538,10 @@ "sim":53.0, "partner":"7zjh" }, + { + "sim":53.0, + "partner":"7zji" + }, { "sim":52.0, "partner":"2etc" @@ -522590,8 +524651,8 @@ ], "subtitle":"Ancestral reconstruction of a plant alpha\/beta-hydrolase", "tags":[ - "ancestral reconstruction", - "hydrolase" + "hydrolase", + "ancestral reconstruction" ], "keywords":[ "description", @@ -522667,11 +524728,11 @@ }, { "sim":408.0, - "partner":"3w05" + "partner":"3w04" }, { "sim":408.0, - "partner":"3w04" + "partner":"3w05" }, { "sim":408.0, @@ -522747,11 +524808,11 @@ }, { "sim":340.0, - "partner":"7k38" + "partner":"7k2z" }, { "sim":340.0, - "partner":"7k2z" + "partner":"7k38" }, { "sim":335.0, @@ -522775,15 +524836,15 @@ }, { "sim":335.0, - "partner":"4hry" + "partner":"4hrx" }, { "sim":335.0, - "partner":"4hta" + "partner":"4hry" }, { "sim":335.0, - "partner":"4hrx" + "partner":"4hta" }, { "sim":332.0, @@ -522909,10 +524970,6 @@ "sim":54.0, "partner":"4lxg" }, - { - "sim":51.0, - "partner":"4lyd" - }, { "sim":51.0, "partner":"4lye" @@ -522925,6 +524982,10 @@ "sim":51.0, "partner":"4lxi" }, + { + "sim":51.0, + "partner":"4lyd" + }, { "sim":50.0, "partner":"6k5e" @@ -523111,101 +525172,101 @@ ], "subtitle":"De novo designed chlorophyll dimer protein in apo state, sp2", "tags":[ - "symmetric", - "apo", "homodimer", - "rosetta", - "design", "designed", - "chlorophyll", + "apo", "de novo protein", + "symmetric", + "design", + "rosetta", "circular tandem repeat protein", - "ctrp" + "ctrp", + "chlorophyll" ], "keywords":[ - "results", "accepts", - "imaging", - "suggest", - "independently", - "crystallography", - "designed", - "current", - "couple", + "technologies", "methods", + "separation", + "within", + "results", + "new", + "model", "chlorophyll", - "complexities", - "synthetic", - "c", - "structure", - "fluorescence", - "harvesting", + "protein", + "positions", + "microscopy", + "pair", + "initiates", + "confirmed", + "novo", "photophysics", - "proteins", - "reach", - "technologies", - "de", - "edge", - "conversion", - "orientation", + "systems", + "two", "binds", - "separation", + "special", + "using", + "creating", + "independently", + "reach", + "cascade", "step", - "excitation", - "positions", - "natural", - "pairs", - "excitonically", - "native", - "revealed", - "first", - "second", - "molecules", - "coupled", + "charge", + "matched", + "complexities", + "proteins", "unseen", + "2", + "conversion", "octahedral", - "systems", - "previously", - "investigate", - "special", - "toward", - "demonstrated", - "geometry", + "harvesting", + "suggest", "antenna", - "photosynthetic", - "artificial", - "closely", - "transfer", - "photosystems", + "computational", + "pairs", + "investigate", + "c", "design", - "model", - "using", - "initiates", "energy", - "juxtaposed", - "one", - "novo", - "chlorophylls", - "lifetime", - "hold", - "matched", - "charge", "spectroscopy", - "confirmed", - "two", - "arrangements", - "creating", + "current", + "hold", + "natural", + "edge", + "orientation", + "excitonically", + "chlorophylls", "light", - "protein", - "microscopy", - "2", - "within", - "computational", + "demonstrated", + "toward", + "whereas", + "couple", + "lifetime", "nanocage", - "cascade", - "pair", - "new", - "whereas" + "designed", + "fluorescence", + "photosystems", + "revealed", + "juxtaposed", + "coupled", + "one", + "geometry", + "de", + "photosynthetic", + "first", + "previously", + "imaging", + "structure", + "synthetic", + "closely", + "crystallography", + "excitation", + "molecules", + "artificial", + "native", + "arrangements", + "second", + "transfer" ], "release_date":"2023-04-19", "publication":"\"De novo design of proteins housing excitonically coupled chlorophyll special pairs\", Nat.Chem.Biol.", @@ -523438,102 +525499,102 @@ ], "subtitle":"De novo designed chlorophyll dimer protein with zn pheophorbide a methyl ester, sp2-znppam", "tags":[ - "symmetric", - "zn", "homodimer", - "rosetta", - "design", "designed", - "chlorophyll", "de novo protein", - "zn pheophorbide a methyl ester", + "symmetric", + "design", + "rosetta", "circular tandem repeat protein", - "ctrp" + "zn pheophorbide a methyl ester", + "ctrp", + "zn", + "chlorophyll" ], "keywords":[ - "results", "accepts", - "imaging", - "suggest", - "independently", - "crystallography", - "designed", - "current", - "couple", + "technologies", "methods", + "separation", + "within", + "results", + "new", + "model", "chlorophyll", - "complexities", - "synthetic", - "c", - "structure", - "fluorescence", - "harvesting", + "protein", + "positions", + "microscopy", + "pair", + "initiates", + "confirmed", + "novo", "photophysics", - "proteins", - "reach", - "technologies", - "de", - "edge", - "conversion", - "orientation", + "systems", + "two", "binds", - "separation", + "special", + "using", + "creating", + "independently", + "reach", + "cascade", "step", - "excitation", - "positions", - "natural", - "pairs", - "excitonically", - "native", - "revealed", - "first", - "second", - "molecules", - "coupled", + "charge", + "matched", + "complexities", + "proteins", "unseen", + "2", + "conversion", "octahedral", - "systems", - "previously", - "investigate", - "special", - "toward", - "demonstrated", - "geometry", + "harvesting", + "suggest", "antenna", - "photosynthetic", - "artificial", - "closely", - "transfer", - "photosystems", + "computational", + "pairs", + "investigate", + "c", "design", - "model", - "using", - "initiates", "energy", - "juxtaposed", - "one", - "novo", - "chlorophylls", - "lifetime", - "hold", - "matched", - "charge", "spectroscopy", - "confirmed", - "two", - "arrangements", - "creating", + "current", + "hold", + "natural", + "edge", + "orientation", + "excitonically", + "chlorophylls", "light", - "protein", - "microscopy", - "2", - "within", - "computational", + "demonstrated", + "toward", + "whereas", + "couple", + "lifetime", "nanocage", - "cascade", - "pair", - "new", - "whereas" + "designed", + "fluorescence", + "photosystems", + "revealed", + "juxtaposed", + "coupled", + "one", + "geometry", + "de", + "photosynthetic", + "first", + "previously", + "imaging", + "structure", + "synthetic", + "closely", + "crystallography", + "excitation", + "molecules", + "artificial", + "native", + "arrangements", + "second", + "transfer" ], "release_date":"2023-04-19", "publication":"\"De novo design of proteins housing excitonically coupled chlorophyll special pairs\", Nat.Chem.Biol.", @@ -523773,101 +525834,101 @@ ], "subtitle":"De novo designed chlorophyll dimer protein with zn pheophorbide a methyl ester matching geometry of purple bacterial special pair, sp1-znppam", "tags":[ - "symmetric", - "apo", "homodimer", - "rosetta", - "design", "designed", - "chlorophyll", + "apo", "de novo protein", + "symmetric", + "design", + "rosetta", "circular tandem repeat protein", - "ctrp" + "ctrp", + "chlorophyll" ], "keywords":[ - "results", "accepts", - "imaging", - "suggest", - "independently", - "crystallography", - "designed", - "current", - "couple", + "technologies", "methods", + "separation", + "within", + "results", + "new", + "model", "chlorophyll", - "complexities", - "synthetic", - "c", - "structure", - "fluorescence", - "harvesting", + "protein", + "positions", + "microscopy", + "pair", + "initiates", + "confirmed", + "novo", "photophysics", - "proteins", - "reach", - "technologies", - "de", - "edge", - "conversion", - "orientation", + "systems", + "two", "binds", - "separation", + "special", + "using", + "creating", + "independently", + "reach", + "cascade", "step", - "excitation", - "positions", - "natural", - "pairs", - "excitonically", - "native", - "revealed", - "first", - "second", - "molecules", - "coupled", + "charge", + "matched", + "complexities", + "proteins", "unseen", + "2", + "conversion", "octahedral", - "systems", - "previously", - "investigate", - "special", - "toward", - "demonstrated", - "geometry", + "harvesting", + "suggest", "antenna", - "photosynthetic", - "artificial", - "closely", - "transfer", - "photosystems", + "computational", + "pairs", + "investigate", + "c", "design", - "model", - "using", - "initiates", "energy", - "juxtaposed", - "one", - "novo", - "chlorophylls", - "lifetime", - "hold", - "matched", - "charge", "spectroscopy", - "confirmed", - "two", - "arrangements", - "creating", + "current", + "hold", + "natural", + "edge", + "orientation", + "excitonically", + "chlorophylls", "light", - "protein", - "microscopy", - "2", - "within", - "computational", + "demonstrated", + "toward", + "whereas", + "couple", + "lifetime", "nanocage", - "cascade", - "pair", - "new", - "whereas" + "designed", + "fluorescence", + "photosystems", + "revealed", + "juxtaposed", + "coupled", + "one", + "geometry", + "de", + "photosynthetic", + "first", + "previously", + "imaging", + "structure", + "synthetic", + "closely", + "crystallography", + "excitation", + "molecules", + "artificial", + "native", + "arrangements", + "second", + "transfer" ], "release_date":"2023-04-19", "publication":"\"De novo design of proteins housing excitonically coupled chlorophyll special pairs\", Nat.Chem.Biol.", @@ -524068,86 +526129,86 @@ ], "subtitle":"Crystal structure of designed heterotrimeric assembly dht03", "tags":[ - "de novo designed protein", - "de novo protein" + "de novo protein", + "de novo designed protein" ], "keywords":[ - "versions", - "modulation", - "obtained", - "designs", - "oligomers", - "chains", - "cyclic", + "designed", + "form", + "heterodimers", + "branching", + "complex", + "nanostructures", + "individual", "junction", - "proteins", - "large", - "larger", + "design", + "cooperatively", + "aromatic", + "ten", + "signaling", "specificity", - "cell", - "extended", + "conferred", + "enhance", + "repeat", + "structurally", + "structures", "de", - "novo", - "challenge", - "signaling", + "used", + "associate", "heterotrimers", - "shape", - "designed", - "enhance", + "possible", + "oligomers", "species", - "fused", - "electron", - "enable", - "scaffolding", - "aromatic", + "three", + "assembly", "residues", - "used", + "important", + "extended", + "shape", + "fused", "orientation", - "assembling", "provide", - "complementary", - "validated", - "crystal", - "heterodimers", - "nanostructures", "new", - "blocks", - "bundle", - "design", + "ligands", + "modulation", + "assembled", + "cyclic", "drive", - "heterotrimer", - "helical", - "structures", "protein", - "assembled", "buried", - "bond", - "present", - "individual", - "microscopy", - "complex", - "construct", - "branching", - "three", - "assembly", - "repeat", - "subunits", + "cell", + "assembling", + "heterotrimer", + "blocks", + "helical", + "large", + "packing", + "proteins", + "electron", "showed", - "networks", - "structurally", + "microscopy", + "enable", "routes", - "distinct", - "ligands", - "form", - "building", - "possible", - "packing", + "validated", + "networks", + "novo", "hydrogen", - "cooperatively", - "important", - "associate", - "conferred", - "ten" + "building", + "distinct", + "larger", + "scaffolding", + "bond", + "subunits", + "present", + "crystal", + "chains", + "construct", + "challenge", + "designs", + "complementary", + "bundle", + "versions", + "obtained" ], "release_date":"2022-12-14", "publication":"\"De novo design of obligate ABC-type heterotrimeric proteins\", Nat.Struct.Mol.Biol., 29, 1266-1276", @@ -524315,86 +526376,86 @@ ], "subtitle":"Crystal structure of designed heterotrimeric assembly dht03_2arm_a21\/b21\/c long", "tags":[ - "de novo designed protein", - "de novo protein" + "de novo protein", + "de novo designed protein" ], "keywords":[ - "versions", - "modulation", - "obtained", - "designs", - "oligomers", - "chains", - "cyclic", + "designed", + "form", + "heterodimers", + "branching", + "complex", + "nanostructures", + "individual", "junction", - "proteins", - "large", - "larger", + "design", + "cooperatively", + "aromatic", + "ten", + "signaling", "specificity", - "cell", - "extended", + "conferred", + "enhance", + "repeat", + "structurally", + "structures", "de", - "novo", - "challenge", - "signaling", + "used", + "associate", "heterotrimers", - "shape", - "designed", - "enhance", + "possible", + "oligomers", "species", - "fused", - "electron", - "enable", - "scaffolding", - "aromatic", + "three", + "assembly", "residues", - "used", + "important", + "extended", + "shape", + "fused", "orientation", - "assembling", "provide", - "complementary", - "validated", - "crystal", - "heterodimers", - "nanostructures", "new", - "blocks", - "bundle", - "design", + "ligands", + "modulation", + "assembled", + "cyclic", "drive", - "heterotrimer", - "helical", - "structures", "protein", - "assembled", "buried", - "bond", - "present", - "individual", - "microscopy", - "complex", - "construct", - "branching", - "three", - "assembly", - "repeat", - "subunits", + "cell", + "assembling", + "heterotrimer", + "blocks", + "helical", + "large", + "packing", + "proteins", + "electron", "showed", - "networks", - "structurally", + "microscopy", + "enable", "routes", - "distinct", - "ligands", - "form", - "building", - "possible", - "packing", + "validated", + "networks", + "novo", "hydrogen", - "cooperatively", - "important", - "associate", - "conferred", - "ten" + "building", + "distinct", + "larger", + "scaffolding", + "bond", + "subunits", + "present", + "crystal", + "chains", + "construct", + "challenge", + "designs", + "complementary", + "bundle", + "versions", + "obtained" ], "release_date":"2022-12-14", "publication":"\"De novo design of obligate ABC-type heterotrimeric proteins\", Nat.Struct.Mol.Biol., 29, 1266-1276", @@ -524425,13 +526486,13 @@ "previous_design":"7upo", "next_design":"7upq", "seq_thr_sim_designed":[ - { - "sim":131.0, - "partner":"7upo" - }, { "sim":315.0, "partner":"7upq" + }, + { + "sim":131.0, + "partner":"7upo" } ], "seq_thr_sim_natural":[ @@ -524562,86 +526623,86 @@ ], "subtitle":"Crystal structure of designed heterotrimeric assembly dht03_1arm_a21\/b\/c", "tags":[ - "de novo designed protein", - "de novo protein" + "de novo protein", + "de novo designed protein" ], "keywords":[ - "versions", - "modulation", - "obtained", - "designs", - "oligomers", - "chains", - "cyclic", + "designed", + "form", + "heterodimers", + "branching", + "complex", + "nanostructures", + "individual", "junction", - "proteins", - "large", - "larger", + "design", + "cooperatively", + "aromatic", + "ten", + "signaling", "specificity", - "cell", - "extended", + "conferred", + "enhance", + "repeat", + "structurally", + "structures", "de", - "novo", - "challenge", - "signaling", + "used", + "associate", "heterotrimers", - "shape", - "designed", - "enhance", + "possible", + "oligomers", "species", - "fused", - "electron", - "enable", - "scaffolding", - "aromatic", + "three", + "assembly", "residues", - "used", + "important", + "extended", + "shape", + "fused", "orientation", - "assembling", "provide", - "complementary", - "validated", - "crystal", - "heterodimers", - "nanostructures", "new", - "blocks", - "bundle", - "design", + "ligands", + "modulation", + "assembled", + "cyclic", "drive", - "heterotrimer", - "helical", - "structures", "protein", - "assembled", "buried", - "bond", - "present", - "individual", - "microscopy", - "complex", - "construct", - "branching", - "three", - "assembly", - "repeat", - "subunits", + "cell", + "assembling", + "heterotrimer", + "blocks", + "helical", + "large", + "packing", + "proteins", + "electron", "showed", - "networks", - "structurally", + "microscopy", + "enable", "routes", - "distinct", - "ligands", - "form", - "building", - "possible", - "packing", + "validated", + "networks", + "novo", "hydrogen", - "cooperatively", - "important", - "associate", - "conferred", - "ten" + "building", + "distinct", + "larger", + "scaffolding", + "bond", + "subunits", + "present", + "crystal", + "chains", + "construct", + "challenge", + "designs", + "complementary", + "bundle", + "versions", + "obtained" ], "release_date":"2022-12-14", "publication":"\"De novo design of obligate ABC-type heterotrimeric proteins\", Nat.Struct.Mol.Biol., 29, 1266-1276", @@ -524804,82 +526865,82 @@ ], "subtitle":"Crystal structure of the small ultra-red fluorescent protein (smurfp)", "tags":[ - "far-red", + "optoacoustic", "smurfp", "fluorescent protein", "phycobiliprotein", - "optoacoustic" + "far-red" ], "keywords":[ + "fluorescence", + "fps", "brightness", - "largest", - "toward", - "evolution", - "produces", + "directed", + "engineering", "molecular", - "monomeric", - "altogether", - "studies", - "represents", - "observe", - "whole", - "use", - "approach", - "imaging", - "report", - "study", - "lifetime", - "class", - "compare", + "phycocyanobilin", + "photostability", + "organic", + "structural", "origins", - "measure", - "directed", "variants", - "identify", - "understand", - "properties", - "enable", - "advanced", - "small", + "observe", + "structures", "expands", - "relevant", - "photophysical", - "necessary", - "optimal", - "develop", - "organism", - "photostability", - "improved", - "crystal", - "engineering", + "understand", + "represents", "smurfp", "furthermore", - "allophycocyanin", - "organic", - "better", - "compatible", - "modalities", - "measured", - "fps", - "structures", - "protein", + "compare", + "imaging", + "properties", + "structure", + "monomeric", + "photons", + "inform", + "fluorescent", + "report", + "new", "exceptional", "dyes", - "fluoresce", - "inform", + "largest", + "relevant", + "measure", + "protein", + "necessary", + "modalities", "derived", - "previous", - "future", - "structure", - "phycocyanobilin", + "altogether", + "study", "understanding", + "approach", + "compatible", + "class", + "improved", + "develop", "mutants", - "fluorescence", + "produces", + "organism", + "measured", + "enable", + "use", + "identify", "biliverdin", - "photons", - "structural", - "new", - "fluorescent" + "small", + "fluoresce", + "evolution", + "allophycocyanin", + "toward", + "photophysical", + "crystal", + "whole", + "studies", + "future", + "lifetime", + "optimal", + "better", + "previous", + "advanced" ], "release_date":"2023-07-19", "publication":"\"Structural and photophysical characterization of the small ultra-red fluorescent protein\", Nat Commun, 14, 4155-4155", @@ -524920,11 +526981,11 @@ }, { "sim":233.0, - "partner":"8j1x" + "partner":"8j98" }, { "sim":233.0, - "partner":"8j98" + "partner":"8j1x" } ], "seq_thr_sim_natural":[ @@ -524950,43 +527011,43 @@ }, { "sim":166.0, - "partner":"7sc9" + "partner":"7sc7" }, { "sim":166.0, - "partner":"7sc7" + "partner":"7scb" }, { "sim":166.0, - "partner":"7scb" + "partner":"7sc9" }, { "sim":158.0, - "partner":"6kgx" + "partner":"7ezx" }, { "sim":158.0, - "partner":"7y7a" + "partner":"7y4l" }, { "sim":158.0, - "partner":"7ext" + "partner":"5y6p" }, { "sim":158.0, - "partner":"7ezx" + "partner":"7y5e" }, { "sim":158.0, - "partner":"7y4l" + "partner":"7ext" }, { "sim":158.0, - "partner":"5y6p" + "partner":"6kgx" }, { "sim":158.0, - "partner":"7y5e" + "partner":"7y7a" }, { "sim":141.0, @@ -525054,15 +527115,15 @@ }, { "sim":83.0, - "partner":"2c7j" + "partner":"2c7k" }, { "sim":83.0, - "partner":"2c7k" + "partner":"2c7l" }, { "sim":83.0, - "partner":"2c7l" + "partner":"2c7j" }, { "sim":80.0, @@ -525082,20 +527143,12 @@ }, { "sim":77.0, - "partner":"6ypq" + "partner":"7eh7" }, { "sim":77.0, "partner":"7veb" }, - { - "sim":77.0, - "partner":"4gy3" - }, - { - "sim":77.0, - "partner":"4n6s" - }, { "sim":77.0, "partner":"3l0f" @@ -525106,11 +527159,7 @@ }, { "sim":77.0, - "partner":"1i7y" - }, - { - "sim":77.0, - "partner":"7eh7" + "partner":"7efv" }, { "sim":77.0, @@ -525118,15 +527167,15 @@ }, { "sim":77.0, - "partner":"1jbo" + "partner":"1i7y" }, { "sim":77.0, - "partner":"4gxe" + "partner":"8fwa" }, { "sim":77.0, - "partner":"7efv" + "partner":"4gxe" }, { "sim":77.0, @@ -525134,7 +527183,7 @@ }, { "sim":77.0, - "partner":"8fwa" + "partner":"1jbo" }, { "sim":77.0, @@ -525146,23 +527195,23 @@ }, { "sim":77.0, - "partner":"4ziz" + "partner":"7efw" }, { "sim":77.0, - "partner":"1on7" + "partner":"4ziz" }, { "sim":77.0, - "partner":"7efw" + "partner":"7eh8" }, { "sim":77.0, - "partner":"4z8k" + "partner":"1on7" }, { "sim":77.0, - "partner":"7eh8" + "partner":"4z8k" }, { "sim":77.0, @@ -525174,11 +527223,11 @@ }, { "sim":77.0, - "partner":"3o18" + "partner":"6yyj" }, { "sim":77.0, - "partner":"6yyj" + "partner":"3o18" }, { "sim":77.0, @@ -525188,13 +527237,25 @@ "sim":77.0, "partner":"5mjq" }, + { + "sim":77.0, + "partner":"6yq8" + }, { "sim":77.0, "partner":"5o7m" }, { "sim":77.0, - "partner":"6yq8" + "partner":"6ypq" + }, + { + "sim":77.0, + "partner":"4gy3" + }, + { + "sim":77.0, + "partner":"4n6s" }, { "sim":76.0, @@ -525202,19 +527263,19 @@ }, { "sim":76.0, - "partner":"7d6w" + "partner":"4yjj" }, { "sim":76.0, - "partner":"2uul" + "partner":"1ha7" }, { "sim":76.0, - "partner":"4yjj" + "partner":"7d6w" }, { "sim":76.0, - "partner":"1ha7" + "partner":"2uul" }, { "sim":76.0, @@ -525284,10 +527345,6 @@ "sim":66.0, "partner":"1lia" }, - { - "sim":64.0, - "partner":"3v57" - }, { "sim":64.0, "partner":"7y1a" @@ -525300,6 +527357,10 @@ "sim":64.0, "partner":"8b4n" }, + { + "sim":64.0, + "partner":"3v57" + }, { "sim":64.0, "partner":"5tou" @@ -525322,15 +527383,15 @@ }, { "sim":63.0, - "partner":"7tja" + "partner":"7tlf" }, { "sim":63.0, - "partner":"7tlf" + "partner":"7t89" }, { "sim":63.0, - "partner":"7t89" + "partner":"7tja" }, { "sim":61.0, @@ -525366,11 +527427,11 @@ }, { "sim":59.0, - "partner":"4lm6" + "partner":"4lmx" }, { "sim":59.0, - "partner":"4lmx" + "partner":"4lm6" }, { "sim":58.0, @@ -525402,11 +527463,11 @@ }, { "sim":53.0, - "partner":"5nb4" + "partner":"5nb3" }, { "sim":53.0, - "partner":"5nb3" + "partner":"5nb4" }, { "sim":53.0, @@ -525532,114 +527593,114 @@ ], "subtitle":"17_bp_sh3, a small beta-barrel de novo designed protein", "tags":[ - "beta-barrel", "protein binder", "de novo protein", + "beta-barrel", "de novo design" ], "keywords":[ - "thermal", - "aggregation", - "stabilizing", - "available", - "thus", - "intermolecular", - "designed", + "ob", + "hydrophobic", + "learning", + "structural", "methods", - "experimentally", - "determined", - "compete", - "rarely", + "intermolecular", + "core", + "free", + "folding", + "protein", + "topologies", + "six", + "increased", + "little", + "novo", "necessarily", - "designing", - "structurally", - "diversity", - "monomer", + "attractive", + "using", + "deep", + "conformational", "however", - "rates", + "interest", + "stabilizing", + "experimentally", + "thus", + "aggregation", "increases", - "proteins", - "challenges", - "models", - "greatly", - "src", - "de", - "\u00e5", - "strain", - "less", - "yielded", - "seen", - "small", - "binders", - "little", - "nature", - "3", - "ability", - "far", - "structures", - "edges", - "ever", - "size", - "free", + "oppose", + "targets", + "thermal", "stability", - "generation", - "considerable", - "homology", - "alone", - "functional", - "amino", - "strand", + "proteins", "large", - "ob", + "size", + "success", + "far", + "small", + "available", + "found", + "sh3", "higher", - "proper", + "monomer", "four", - "topologies", - "70", - "sh3", - "increased", - "acids", - "shape", - "interest", - "oppose", - "approaches", - "successful", - "six", - "closure", + "barrel", + "computational", + "rates", + "alone", + "set", + "designing", "design", - "core", - "using", - "hydrophobic", - "high", - "sequence", - "learning", - "structural", + "beta", + "strain", "diverse", - "designs", - "despite", - "conformational", - "also", - "barrels", - "novo", - "success", - "barrel", - "attractive", + "binders", + "functional", + "proper", + "ever", "rosetta", "fold", - "found", - "folds", - "set", + "diversity", + "also", + "successful", + "seen", "explore", - "protein", - "targets", + "amino", + "compete", + "src", + "closure", "backbone", + "ability", + "sequence", + "folds", + "designed", + "rmsd", + "models", + "generation", "space", - "beta", - "computational", - "deep", - "folding", - "five", - "rmsd" + "structurally", + "structures", + "de", + "approaches", + "3", + "70", + "\u00e5", + "challenges", + "shape", + "determined", + "nature", + "rarely", + "greatly", + "yielded", + "considerable", + "strand", + "high", + "homology", + "acids", + "despite", + "designs", + "edges", + "less", + "barrels", + "five" ], "release_date":"2023-03-22", "publication":"\"De novo design of small beta barrel proteins\", Proc.Natl.Acad.Sci.USA, 120, e2207974120-e2207974120", @@ -525789,114 +527850,114 @@ ], "subtitle":"170_h_ob, a small beta-barrel de novo designed protein", "tags":[ - "beta-barrel", "protein binder", "de novo protein", + "beta-barrel", "de novo design" ], "keywords":[ - "thermal", - "aggregation", - "stabilizing", - "available", - "thus", - "intermolecular", - "designed", + "ob", + "hydrophobic", + "learning", + "structural", "methods", - "experimentally", - "determined", - "compete", - "rarely", + "intermolecular", + "core", + "free", + "folding", + "protein", + "topologies", + "six", + "increased", + "little", + "novo", "necessarily", - "designing", - "structurally", - "diversity", - "monomer", + "attractive", + "using", + "deep", + "conformational", "however", - "rates", + "interest", + "stabilizing", + "experimentally", + "thus", + "aggregation", "increases", - "proteins", - "challenges", - "models", - "greatly", - "src", - "de", - "\u00e5", - "strain", - "less", - "yielded", - "seen", - "small", - "binders", - "little", - "nature", - "3", - "ability", - "far", - "structures", - "edges", - "ever", - "size", - "free", + "oppose", + "targets", + "thermal", "stability", - "generation", - "considerable", - "homology", - "alone", - "functional", - "amino", - "strand", + "proteins", "large", - "ob", + "size", + "success", + "far", + "small", + "available", + "found", + "sh3", "higher", - "proper", + "monomer", "four", - "topologies", - "70", - "sh3", - "increased", - "acids", - "shape", - "interest", - "oppose", - "approaches", - "successful", - "six", - "closure", + "barrel", + "computational", + "rates", + "alone", + "set", + "designing", "design", - "core", - "using", - "hydrophobic", - "high", - "sequence", - "learning", - "structural", + "beta", + "strain", "diverse", - "designs", - "despite", - "conformational", - "also", - "barrels", - "novo", - "success", - "barrel", - "attractive", + "binders", + "functional", + "proper", + "ever", "rosetta", "fold", - "found", - "folds", - "set", + "diversity", + "also", + "successful", + "seen", "explore", - "protein", - "targets", + "amino", + "compete", + "src", + "closure", "backbone", + "ability", + "sequence", + "folds", + "designed", + "rmsd", + "models", + "generation", "space", - "beta", - "computational", - "deep", - "folding", - "five", - "rmsd" + "structurally", + "structures", + "de", + "approaches", + "3", + "70", + "\u00e5", + "challenges", + "shape", + "determined", + "nature", + "rarely", + "greatly", + "yielded", + "considerable", + "strand", + "high", + "homology", + "acids", + "despite", + "designs", + "edges", + "less", + "barrels", + "five" ], "release_date":"2023-03-22", "publication":"\"De novo design of small beta barrel proteins\", Proc.Natl.Acad.Sci.USA, 120, e2207974120-e2207974120", @@ -526024,80 +528085,80 @@ ], "subtitle":"Cryo-em of self-assembling pyrene idp", "tags":[ + "peptides", "self-assembly peptide filament", - "nanofibers", "protein fibril", - "peptides" + "nanofibers" ], "keywords":[ - "work", - "containing", - "5", - "molecular", - "noncovalent", "chemistry", - "amino", - "lack", - "assemblies", - "report", - "bundles", - "ions", - "metal", - "nanoparticles", - "phosphorylation", - "protonating", - "flexible", - "driven", - "peptide", - "fibrils", - "understand", - "peptides", - "acids", - "enhance", - "controlled", - "nanofibers", - "analogs", - "transit", - "remains", - "short", - "lowering", - "phosphate", + "form", "periphery", - "interact", - "due", - "site", - "disorder", - "limited", - "atomistic", "order", - "core", + "limited", "individual", + "controlled", + "aromatic", + "metal", + "assembles", + "bundles", + "hydrophobic", + "calcium", "sequences", + "indicate", + "enhance", + "work", + "insights", "structures", - "upon", + "phosphate", + "disorder", + "nanoparticles", + "due", + "intrinsically", + "analogs", + "phosphorylation", + "understand", + "core", "idp", + "remains", + "transitions", + "structure", + "report", + "short", + "flexible", + "driven", + "disordered", "interactions", - "idps", - "2", + "illustrating", + "ph", + "understanding", "adding", + "5", + "amino", + "interact", + "fibrils", + "ions", + "2", "filament", - "hydrophobic", - "illustrating", - "offers", - "disordered", - "structure", - "transitions", + "site", + "noncovalent", + "upon", + "protonating", "interfibrillar", - "indicate", - "insights", - "understanding", - "calcium", - "form", - "ph", + "nanofibers", + "idps", "comprised", - "assembles", - "intrinsically", - "aromatic" + "peptides", + "acids", + "assemblies", + "transit", + "atomistic", + "containing", + "offers", + "peptide", + "lack", + "molecular", + "lowering" ], "release_date":"2023-05-10", "publication":"\"Hierarchical Assembly of Intrinsically Disordered Short Peptides\", Chem, 9, 2530-2546", @@ -526244,115 +528305,115 @@ ], "subtitle":"Nmr solution structure of the de novo designed small beta-barrel protein 29_bp_sh3", "tags":[ - "high-throughput screening", + "machine learning", "de novo protein", "small beta barrels", "protein design", - "machine learning" + "high-throughput screening" ], "keywords":[ - "thermal", - "aggregation", - "stabilizing", - "available", - "thus", - "intermolecular", - "designed", + "ob", + "hydrophobic", + "learning", + "structural", "methods", - "experimentally", - "determined", - "compete", - "rarely", + "intermolecular", + "core", + "free", + "folding", + "protein", + "topologies", + "six", + "increased", + "little", + "novo", "necessarily", - "designing", - "structurally", - "diversity", - "monomer", + "attractive", + "using", + "deep", + "conformational", "however", - "rates", + "interest", + "stabilizing", + "experimentally", + "thus", + "aggregation", "increases", - "proteins", - "challenges", - "models", - "greatly", - "src", - "de", - "\u00e5", - "strain", - "less", - "yielded", - "seen", - "small", - "binders", - "little", - "nature", - "3", - "ability", - "far", - "structures", - "edges", - "ever", - "size", - "free", + "oppose", + "targets", + "thermal", "stability", - "generation", - "considerable", - "homology", - "alone", - "functional", - "amino", - "strand", + "proteins", "large", - "ob", + "size", + "success", + "far", + "small", + "available", + "found", + "sh3", "higher", - "proper", + "monomer", "four", - "topologies", - "70", - "sh3", - "increased", - "acids", - "shape", - "interest", - "oppose", - "approaches", - "successful", - "six", - "closure", + "barrel", + "computational", + "rates", + "alone", + "set", + "designing", "design", - "core", - "using", - "hydrophobic", - "high", - "sequence", - "learning", - "structural", + "beta", + "strain", "diverse", - "designs", - "despite", - "conformational", - "also", - "barrels", - "novo", - "success", - "barrel", - "attractive", + "binders", + "functional", + "proper", + "ever", "rosetta", "fold", - "found", - "folds", - "set", + "diversity", + "also", + "successful", + "seen", "explore", - "protein", - "targets", + "amino", + "compete", + "src", + "closure", "backbone", + "ability", + "sequence", + "folds", + "designed", + "rmsd", + "models", + "generation", "space", - "beta", - "computational", - "deep", - "folding", - "five", - "rmsd" + "structurally", + "structures", + "de", + "approaches", + "3", + "70", + "\u00e5", + "challenges", + "shape", + "determined", + "nature", + "rarely", + "greatly", + "yielded", + "considerable", + "strand", + "high", + "homology", + "acids", + "despite", + "designs", + "edges", + "less", + "barrels", + "five" ], "release_date":"2023-03-22", "publication":"\"De novo design of small beta barrel proteins\", Proc.Natl.Acad.Sci.USA, 120, e2207974120-e2207974120", @@ -526502,115 +528563,115 @@ ], "subtitle":"Nmr solution structure of the de novo designed small beta-barrel protein 33_bp_sh3", "tags":[ - "high-throughput screening", + "machine learning", "de novo protein", "small beta barrels", "protein design", - "machine learning" + "high-throughput screening" ], "keywords":[ - "thermal", - "aggregation", - "stabilizing", - "available", - "thus", - "intermolecular", - "designed", + "ob", + "hydrophobic", + "learning", + "structural", "methods", - "experimentally", - "determined", - "compete", - "rarely", + "intermolecular", + "core", + "free", + "folding", + "protein", + "topologies", + "six", + "increased", + "little", + "novo", "necessarily", - "designing", - "structurally", - "diversity", - "monomer", + "attractive", + "using", + "deep", + "conformational", "however", - "rates", + "interest", + "stabilizing", + "experimentally", + "thus", + "aggregation", "increases", - "proteins", - "challenges", - "models", - "greatly", - "src", - "de", - "\u00e5", - "strain", - "less", - "yielded", - "seen", - "small", - "binders", - "little", - "nature", - "3", - "ability", - "far", - "structures", - "edges", - "ever", - "size", - "free", + "oppose", + "targets", + "thermal", "stability", - "generation", - "considerable", - "homology", - "alone", - "functional", - "amino", - "strand", + "proteins", "large", - "ob", + "size", + "success", + "far", + "small", + "available", + "found", + "sh3", "higher", - "proper", + "monomer", "four", - "topologies", - "70", - "sh3", - "increased", - "acids", - "shape", - "interest", - "oppose", - "approaches", - "successful", - "six", - "closure", + "barrel", + "computational", + "rates", + "alone", + "set", + "designing", "design", - "core", - "using", - "hydrophobic", - "high", - "sequence", - "learning", - "structural", + "beta", + "strain", "diverse", - "designs", - "despite", - "conformational", - "also", - "barrels", - "novo", - "success", - "barrel", - "attractive", + "binders", + "functional", + "proper", + "ever", "rosetta", "fold", - "found", - "folds", - "set", + "diversity", + "also", + "successful", + "seen", "explore", - "protein", - "targets", + "amino", + "compete", + "src", + "closure", "backbone", + "ability", + "sequence", + "folds", + "designed", + "rmsd", + "models", + "generation", "space", - "beta", - "computational", - "deep", - "folding", - "five", - "rmsd" + "structurally", + "structures", + "de", + "approaches", + "3", + "70", + "\u00e5", + "challenges", + "shape", + "determined", + "nature", + "rarely", + "greatly", + "yielded", + "considerable", + "strand", + "high", + "homology", + "acids", + "despite", + "designs", + "edges", + "less", + "barrels", + "five" ], "release_date":"2023-03-22", "publication":"\"De novo design of small beta barrel proteins\", Proc.Natl.Acad.Sci.USA, 120, e2207974120-e2207974120", @@ -526800,89 +528861,89 @@ ], "subtitle":"Solution nmr structure of 9-residue rosetta-designed cyclic peptide d9.16 in cdcl3 with cis\/trans switching (b-tc conformation)", "tags":[ - "switch peptides", - "cis\/trans", + "de novo design", "non natural amino acids", "de novo protein", - "cyclic peptide", - "de novo design", - "membrane permeability" + "switch peptides", + "membrane permeability", + "cis\/trans", + "cyclic peptide" ], "keywords":[ - "predicted", - "35", - "accuracy", - "containing", - "control", - "structural", - "generation", - "designs", + "membranes", + "designed", + "made", + "permeable", + "alternative", "robustly", - "amide", - "engaged", - "membrane", + "orally", "models", + "generation", + "coupled", + "design", + "structural", + "exposed", + "show", + "principles", + "experimental", + "structures", + "therapeutics", + "cross", + "experimentally", + "amide", + "contribute", + "apparent", + "determined", + "residue", "groups", - "membranes", - "use", - "systematically", - "close", - "wide", "noncanonical", - "experimental", - "nh", - "1", - "permeable", - "designed", - "29", - "orally", - "bioavailability", - "peptides", - "macrocycle", - "84", - "10", "bioavailable", - "range", - "fully", - "experimentally", - "modifications", + "control", + "interactions", "state", - "determined", - "cross", - "made", - "ability", - "hydrogen", - "show", - "design", - "bonding", - "apparent", - "characterization", "macrocycles", - "next", - "structures", - "interactions", - "residue", + "membrane", + "wide", + "modifications", + "macrocycle", "lipid", - "therapeutics", + "achieved", + "internal", + "fully", + "accuracy", + "characterization", + "size", + "next", + "close", + "use", "backbone", - "ensuring", + "permeability", + "29", + "1", + "ability", "high", + "bioavailability", + "hydrogen", + "predicted", "favored", - "size", - "184", - "computational", - "permeability", - "principles", - "achieved", "greater", - "coupled", + "engaged", + "peptides", + "range", + "designs", + "10", "oral", - "alternative", - "internal", - "exposed", - "contribute", + "containing", + "computational", + "ensuring", + "35", + "nh", + "systematically", "isoenergetic", - "investigate" + "investigate", + "184", + "84", + "bonding" ], "release_date":"2022-09-14", "publication":"\"Accurate de novo design of membrane-traversing macrocycles\", Cell, 185, 3520-3532.e26", @@ -526968,8 +529029,8 @@ ], "subtitle":"De novo designed based on 1r26", "tags":[ - "de nove design protein", - "de novo protein" + "de novo protein", + "de nove design protein" ], "keywords":[ "description", @@ -527324,11 +529385,11 @@ }, { "sim":59.0, - "partner":"4puf" + "partner":"4pob" }, { "sim":59.0, - "partner":"4pob" + "partner":"4puf" }, { "sim":59.0, @@ -527450,10 +529511,6 @@ "sim":57.0, "partner":"2puk" }, - { - "sim":57.0, - "partner":"1tk5" - }, { "sim":57.0, "partner":"1sl0" @@ -527562,6 +529619,10 @@ "sim":57.0, "partner":"1t8e" }, + { + "sim":57.0, + "partner":"1tk5" + }, { "sim":57.0, "partner":"6p7e" @@ -527580,11 +529641,11 @@ }, { "sim":57.0, - "partner":"5hr1" + "partner":"6n7w" }, { "sim":57.0, - "partner":"6n7w" + "partner":"5hr1" }, { "sim":57.0, @@ -527634,10 +529695,6 @@ "sim":57.0, "partner":"6lur" }, - { - "sim":57.0, - "partner":"6y4y" - }, { "sim":57.0, "partner":"6y4z" @@ -527648,12 +529705,16 @@ }, { "sim":57.0, - "partner":"7scd" + "partner":"6y4y" }, { "sim":57.0, "partner":"7sce" }, + { + "sim":57.0, + "partner":"7scd" + }, { "sim":57.0, "partner":"6yt3" @@ -527670,10 +529731,6 @@ "sim":57.0, "partner":"8qsz" }, - { - "sim":56.0, - "partner":"1nw2" - }, { "sim":56.0, "partner":"1rqm" @@ -527702,6 +529759,10 @@ "sim":56.0, "partner":"3trx" }, + { + "sim":56.0, + "partner":"1nw2" + }, { "sim":56.0, "partner":"2o87" @@ -527724,11 +529785,11 @@ }, { "sim":56.0, - "partner":"3qfb" + "partner":"3qfa" }, { "sim":56.0, - "partner":"3qfa" + "partner":"3qfb" }, { "sim":56.0, @@ -527760,11 +529821,11 @@ }, { "sim":55.0, - "partner":"6gnd" + "partner":"2tir" }, { "sim":55.0, - "partner":"2tir" + "partner":"6gnd" }, { "sim":55.0, @@ -527792,27 +529853,27 @@ }, { "sim":54.0, - "partner":"4ll4" + "partner":"4ll1" }, { "sim":54.0, - "partner":"4ll1" + "partner":"4i8b" }, { "sim":54.0, - "partner":"4i8b" + "partner":"4ll4" }, { "sim":54.0, - "partner":"1xwb" + "partner":"1xw9" }, { "sim":54.0, - "partner":"1xwc" + "partner":"1xwb" }, { "sim":54.0, - "partner":"1xw9" + "partner":"1xwc" }, { "sim":54.0, @@ -527844,11 +529905,11 @@ }, { "sim":54.0, - "partner":"6nup" + "partner":"6mza" }, { "sim":54.0, - "partner":"6mza" + "partner":"6nup" }, { "sim":53.0, @@ -527868,11 +529929,11 @@ }, { "sim":53.0, - "partner":"6yev" + "partner":"7ool" }, { "sim":53.0, - "partner":"7ool" + "partner":"6yev" }, { "sim":53.0, @@ -527900,23 +529961,23 @@ }, { "sim":52.0, - "partner":"1mdj" + "partner":"1cqg" }, { "sim":52.0, - "partner":"1mdk" + "partner":"1cqh" }, { "sim":52.0, - "partner":"1cqg" + "partner":"1mdi" }, { "sim":52.0, - "partner":"1cqh" + "partner":"1mdj" }, { "sim":52.0, - "partner":"1mdi" + "partner":"1mdk" }, { "sim":52.0, @@ -527964,11 +530025,11 @@ }, { "sim":50.0, - "partner":"7moq" + "partner":"6zyw" }, { "sim":50.0, - "partner":"6zyw" + "partner":"7moq" }, { "sim":50.0, @@ -528048,7 +530109,7 @@ "ISSN":"2662-8457", "ASTM":"" }, - "publication_country":"", + "publication_country":"US", "abstract":"No description found.", "crystal_structure":{ "length_a":"41.516", @@ -528398,10 +530459,6 @@ "sim":60.0, "partner":"3die" }, - { - "sim":60.0, - "partner":"1tk5" - }, { "sim":60.0, "partner":"1sl0" @@ -528472,11 +530529,11 @@ }, { "sim":60.0, - "partner":"1t7p" + "partner":"6gn9" }, { "sim":60.0, - "partner":"6gn9" + "partner":"1t7p" }, { "sim":60.0, @@ -528510,6 +530567,10 @@ "sim":60.0, "partner":"1t8e" }, + { + "sim":60.0, + "partner":"1tk5" + }, { "sim":60.0, "partner":"6p7e" @@ -528524,11 +530585,11 @@ }, { "sim":60.0, - "partner":"5hr1" + "partner":"6n7w" }, { "sim":60.0, - "partner":"6n7w" + "partner":"5hr1" }, { "sim":60.0, @@ -528562,10 +530623,6 @@ "sim":60.0, "partner":"6lur" }, - { - "sim":60.0, - "partner":"6y4y" - }, { "sim":60.0, "partner":"6y4z" @@ -528576,12 +530633,16 @@ }, { "sim":60.0, - "partner":"7scd" + "partner":"6y4y" }, { "sim":60.0, "partner":"7sce" }, + { + "sim":60.0, + "partner":"7scd" + }, { "sim":60.0, "partner":"6yt3" @@ -528666,10 +530727,6 @@ "sim":58.0, "partner":"1eru" }, - { - "sim":58.0, - "partner":"1nw2" - }, { "sim":58.0, "partner":"5dqy" @@ -528688,11 +530745,11 @@ }, { "sim":58.0, - "partner":"1auc" + "partner":"4aj7" }, { "sim":58.0, - "partner":"4aj7" + "partner":"1auc" }, { "sim":58.0, @@ -528738,6 +530795,10 @@ "sim":58.0, "partner":"3m9k" }, + { + "sim":58.0, + "partner":"1nw2" + }, { "sim":58.0, "partner":"1ert" @@ -528808,11 +530869,11 @@ }, { "sim":57.0, - "partner":"3qfb" + "partner":"3qfa" }, { "sim":57.0, - "partner":"3qfa" + "partner":"3qfb" }, { "sim":57.0, @@ -528856,11 +530917,11 @@ }, { "sim":56.0, - "partner":"6yev" + "partner":"7ool" }, { "sim":56.0, - "partner":"7ool" + "partner":"6yev" }, { "sim":56.0, @@ -528868,23 +530929,23 @@ }, { "sim":55.0, - "partner":"4ll4" + "partner":"4ll1" }, { "sim":55.0, - "partner":"4ll1" + "partner":"4ll4" }, { "sim":55.0, - "partner":"1xwb" + "partner":"1xw9" }, { "sim":55.0, - "partner":"1xwc" + "partner":"1xwb" }, { "sim":55.0, - "partner":"1xw9" + "partner":"1xwc" }, { "sim":55.0, @@ -528944,11 +531005,11 @@ }, { "sim":55.0, - "partner":"6nup" + "partner":"6mza" }, { "sim":55.0, - "partner":"6mza" + "partner":"6nup" }, { "sim":55.0, @@ -528988,35 +531049,35 @@ }, { "sim":53.0, - "partner":"1mdj" + "partner":"1cqg" }, { "sim":53.0, - "partner":"1mdk" + "partner":"1cqh" }, { "sim":53.0, - "partner":"1cqg" + "partner":"4i8b" }, { "sim":53.0, - "partner":"1cqh" + "partner":"1mdi" }, { "sim":53.0, - "partner":"4i8b" + "partner":"1mdj" }, { "sim":53.0, - "partner":"1mdi" + "partner":"1mdk" }, { "sim":53.0, - "partner":"7moq" + "partner":"6zyw" }, { "sim":53.0, - "partner":"6zyw" + "partner":"7moq" }, { "sim":53.0, @@ -529472,11 +531533,11 @@ }, { "sim":59.0, - "partner":"2pu9" + "partner":"2pvo" }, { "sim":59.0, - "partner":"2pvo" + "partner":"2pu9" }, { "sim":59.0, @@ -529504,11 +531565,11 @@ }, { "sim":58.0, - "partner":"1nw2" + "partner":"1rqm" }, { "sim":58.0, - "partner":"1rqm" + "partner":"1nw2" }, { "sim":58.0, @@ -529590,10 +531651,6 @@ "sim":57.0, "partner":"1dby" }, - { - "sim":57.0, - "partner":"1tk5" - }, { "sim":57.0, "partner":"1sl0" @@ -529710,6 +531767,10 @@ "sim":57.0, "partner":"1t8e" }, + { + "sim":57.0, + "partner":"1tk5" + }, { "sim":57.0, "partner":"6p7e" @@ -529724,11 +531785,11 @@ }, { "sim":57.0, - "partner":"5hr1" + "partner":"6n7w" }, { "sim":57.0, - "partner":"6n7w" + "partner":"5hr1" }, { "sim":57.0, @@ -529782,10 +531843,6 @@ "sim":57.0, "partner":"6lur" }, - { - "sim":57.0, - "partner":"6y4y" - }, { "sim":57.0, "partner":"6y4z" @@ -529796,12 +531853,16 @@ }, { "sim":57.0, - "partner":"7scd" + "partner":"6y4y" }, { "sim":57.0, "partner":"7sce" }, + { + "sim":57.0, + "partner":"7scd" + }, { "sim":57.0, "partner":"6yt3" @@ -529860,15 +531921,15 @@ }, { "sim":56.0, - "partner":"1xwb" + "partner":"1xw9" }, { "sim":56.0, - "partner":"1xwc" + "partner":"1xwb" }, { "sim":56.0, - "partner":"1xw9" + "partner":"1xwc" }, { "sim":56.0, @@ -529880,11 +531941,11 @@ }, { "sim":56.0, - "partner":"7moq" + "partner":"6zyw" }, { "sim":56.0, - "partner":"6zyw" + "partner":"7moq" }, { "sim":56.0, @@ -529956,11 +532017,11 @@ }, { "sim":55.0, - "partner":"6nup" + "partner":"6mza" }, { "sim":55.0, - "partner":"6mza" + "partner":"6nup" }, { "sim":55.0, @@ -530000,11 +532061,11 @@ }, { "sim":54.0, - "partner":"3qfb" + "partner":"3qfa" }, { "sim":54.0, - "partner":"3qfa" + "partner":"3qfb" }, { "sim":54.0, @@ -530052,15 +532113,15 @@ }, { "sim":52.0, - "partner":"4ll4" + "partner":"4ll1" }, { "sim":52.0, - "partner":"4ll1" + "partner":"4i8b" }, { "sim":52.0, - "partner":"4i8b" + "partner":"4ll4" }, { "sim":52.0, @@ -530080,31 +532141,31 @@ }, { "sim":51.0, - "partner":"1mdj" + "partner":"3e3e" }, { "sim":51.0, - "partner":"1mdk" + "partner":"1cqg" }, { "sim":51.0, - "partner":"3e3e" + "partner":"3kd0" }, { "sim":51.0, - "partner":"1cqg" + "partner":"1cqh" }, { "sim":51.0, - "partner":"1cqh" + "partner":"1mdi" }, { "sim":51.0, - "partner":"3kd0" + "partner":"1mdj" }, { "sim":51.0, - "partner":"1mdi" + "partner":"1mdk" }, { "sim":51.0, @@ -530118,10 +532179,6 @@ "sim":51.0, "partner":"3hyp" }, - { - "sim":50.0, - "partner":"6gnd" - }, { "sim":50.0, "partner":"4hu9" @@ -530134,6 +532191,10 @@ "sim":50.0, "partner":"4hu7" }, + { + "sim":50.0, + "partner":"6gnd" + }, { "sim":50.0, "partner":"6zmu" @@ -530773,15 +532834,15 @@ }, { "sim":57.0, - "partner":"1xwb" + "partner":"1xw9" }, { "sim":57.0, - "partner":"1xwc" + "partner":"1xwb" }, { "sim":57.0, - "partner":"1xw9" + "partner":"1xwc" }, { "sim":57.0, @@ -530797,11 +532858,11 @@ }, { "sim":57.0, - "partner":"7moq" + "partner":"6zyw" }, { "sim":57.0, - "partner":"6zyw" + "partner":"7moq" }, { "sim":57.0, @@ -530873,11 +532934,11 @@ }, { "sim":55.0, - "partner":"2pu9" + "partner":"2pvo" }, { "sim":55.0, - "partner":"2pvo" + "partner":"2pu9" }, { "sim":55.0, @@ -530999,10 +533060,6 @@ "sim":53.0, "partner":"6zom" }, - { - "sim":53.0, - "partner":"3qfb" - }, { "sim":53.0, "partner":"2l59" @@ -531017,15 +533074,15 @@ }, { "sim":53.0, - "partner":"2i1u" + "partner":"3qfb" }, { "sim":53.0, - "partner":"4wxt" + "partner":"2i1u" }, { "sim":53.0, - "partner":"6y4y" + "partner":"4wxt" }, { "sim":53.0, @@ -531036,12 +533093,12 @@ "partner":"6y73" }, { - "sim":52.0, - "partner":"5ikn" + "sim":53.0, + "partner":"6y4y" }, { "sim":52.0, - "partner":"1tk5" + "partner":"5ikn" }, { "sim":52.0, @@ -531159,6 +533216,10 @@ "sim":52.0, "partner":"1t8e" }, + { + "sim":52.0, + "partner":"1tk5" + }, { "sim":52.0, "partner":"6p7e" @@ -531173,11 +533234,11 @@ }, { "sim":52.0, - "partner":"5hr1" + "partner":"6n7w" }, { "sim":52.0, - "partner":"6n7w" + "partner":"5hr1" }, { "sim":52.0, @@ -531217,11 +533278,11 @@ }, { "sim":52.0, - "partner":"7scd" + "partner":"7sce" }, { "sim":52.0, - "partner":"7sce" + "partner":"7scd" }, { "sim":52.0, @@ -531239,10 +533300,6 @@ "sim":52.0, "partner":"8qsz" }, - { - "sim":51.0, - "partner":"4ll4" - }, { "sim":51.0, "partner":"3e3e" @@ -531255,6 +533312,10 @@ "sim":51.0, "partner":"3kd0" }, + { + "sim":51.0, + "partner":"4ll4" + }, { "sim":51.0, "partner":"2h6z" @@ -531281,23 +533342,23 @@ }, { "sim":50.0, - "partner":"1mdj" + "partner":"1cqg" }, { "sim":50.0, - "partner":"1mdk" + "partner":"1cqh" }, { "sim":50.0, - "partner":"1cqg" + "partner":"1mdi" }, { "sim":50.0, - "partner":"1cqh" + "partner":"1mdj" }, { "sim":50.0, - "partner":"1mdi" + "partner":"1mdk" }, { "sim":50.0, @@ -531398,8 +533459,8 @@ ], "subtitle":"Ancestral l-lys oxidase (ancllyso-2) ligand free form", "tags":[ - "ancestral sequence reconstruction", "ligand free form", + "ancestral sequence reconstruction", "oxidoreductase" ], "keywords":[ @@ -531437,11 +533498,11 @@ "seq_thr_sim_designed":[ { "sim":1257.0, - "partner":"7x7j" + "partner":"7x7k" }, { "sim":1257.0, - "partner":"7x7k" + "partner":"7x7j" }, { "sim":173.0, @@ -531467,19 +533528,19 @@ }, { "sim":79.0, - "partner":"7c4k" + "partner":"7c4m" }, { "sim":79.0, - "partner":"7c4l" + "partner":"7c4n" }, { "sim":79.0, - "partner":"7c4m" + "partner":"7c4k" }, { "sim":79.0, - "partner":"7c4n" + "partner":"7c4l" } ], "struct_thr_sim_designed":[ @@ -531497,7 +533558,7 @@ ], "seq_max_sim_designed":{ "sim":1257.0, - "partner":"7x7j" + "partner":"7x7k" }, "seq_max_sim_natural":{ "sim":205.0, @@ -531571,9 +533632,9 @@ ], "subtitle":"Ancestral l-lys oxidase (ancllyso-2) l-lys binding form", "tags":[ - "l-lys oxidase", - "ancestral sequence reconstruction", "l-lys binding form", + "ancestral sequence reconstruction", + "l-lys oxidase", "oxidoreductase" ], "keywords":[ @@ -531611,11 +533672,11 @@ "seq_thr_sim_designed":[ { "sim":1257.0, - "partner":"7x7i" + "partner":"7x7k" }, { "sim":1257.0, - "partner":"7x7k" + "partner":"7x7i" }, { "sim":173.0, @@ -531641,19 +533702,19 @@ }, { "sim":79.0, - "partner":"7c4k" + "partner":"7c4m" }, { "sim":79.0, - "partner":"7c4l" + "partner":"7c4n" }, { "sim":79.0, - "partner":"7c4m" + "partner":"7c4k" }, { "sim":79.0, - "partner":"7c4n" + "partner":"7c4l" } ], "struct_thr_sim_designed":[ @@ -531671,7 +533732,7 @@ ], "seq_max_sim_designed":{ "sim":1257.0, - "partner":"7x7i" + "partner":"7x7k" }, "seq_max_sim_natural":{ "sim":205.0, @@ -531745,10 +533806,10 @@ ], "subtitle":"Ancestral l-lys oxidase (ancllyso-2) l-arg binding form", "tags":[ - "l-lys oxidase", "ancestral sequence reconstruction", - "l-arg binding form", - "oxidoreductase" + "l-lys oxidase", + "oxidoreductase", + "l-arg binding form" ], "keywords":[ "description", @@ -531785,11 +533846,11 @@ "seq_thr_sim_designed":[ { "sim":1257.0, - "partner":"7x7i" + "partner":"7x7j" }, { "sim":1257.0, - "partner":"7x7j" + "partner":"7x7i" }, { "sim":173.0, @@ -531815,19 +533876,19 @@ }, { "sim":79.0, - "partner":"7c4k" + "partner":"7c4m" }, { "sim":79.0, - "partner":"7c4l" + "partner":"7c4n" }, { "sim":79.0, - "partner":"7c4m" + "partner":"7c4k" }, { "sim":79.0, - "partner":"7c4n" + "partner":"7c4l" } ], "struct_thr_sim_designed":[ @@ -531845,7 +533906,7 @@ ], "seq_max_sim_designed":{ "sim":1257.0, - "partner":"7x7i" + "partner":"7x7j" }, "seq_max_sim_natural":{ "sim":205.0, @@ -531915,106 +533976,106 @@ ], "subtitle":"Cryo-em structure of mtip60-ba (metal-ion induced tip60 (k67e) complex with barium ions", "tags":[ - "protein nanoparticle", - "artificial designed protein complex", "metal-induced protein assembly", - "protein metal complex", + "de novo protein", + "artificial designed protein complex", "protein cage", - "de novo protein" + "protein nanoparticle", + "protein metal complex" ], "keywords":[ - "analysis", - "require", - "alkaline", - "results", - "prevented", - "available", - "ae", - "use", - "metal", - "challenge", - "ions", - "increasing", - "designed", - "bases", - "ba", - "borderline", - "provide", - "favor", - "mutation", + "insights", "show", - "sr", - "interactions", - "associating", - "connecting", - "structure", - "zn", "hard", - "insights", - "recently", - "however", - "base", - "composed", - "proteins", + "presence", + "borderline", + "results", "soft", - "reversible", - "coordination", - "dna", - "au", + "drive", + "classified", + "protein", "indicated", - "restricting", - "capsules", + "electron", + "dissociation", + "microscopy", + "coordination", + "composed", + "expected", + "zn", + "using", + "associating", + "introduction", "typically", - "presence", - "interface", + "however", + "metal", + "mechanisms", + "formed", + "interest", + "connecting", "furthermore", - "k67e", + "dna", + "residues", + "release", "times", - "drive", - "concept", - "introduction", - "tip60", + "approach", + "proteins", + "ions", + "use", + "cage", + "interface", + "available", + "restricting", + "subunits", + "mutant", + "favor", + "base", + "bases", "ca", - "appropriate", + "surface", + "design", "fusion", - "molecules", + "cryogenic", "nanocages", + "appropriate", + "reversible", + "addressing", + "earth", "glu", - "expected", + "formation", + "promising", + "types", "demonstrated", - "cage", - "release", - "addressing", - "artificial", - "acids", - "mutant", - "interest", - "design", - "classified", - "using", + "system", + "ae", + "increasing", + "mutation", + "nanocage", + "designed", + "analysis", + "require", + "alkaline", + "one", "association", - "surface", - "promising", "encapsulation", - "subunits", - "formation", + "concept", + "structure", + "provide", + "au", + "tip60", + "recently", + "interactions", "ion", - "dissociation", - "one", - "approach", + "prevented", "drug", - "electron", - "residues", + "k67e", + "molecules", + "artificial", "cys", - "system", - "protein", - "microscopy", - "mechanisms", - "types", - "earth", - "nanocage", - "cryogenic", - "formed" + "sr", + "acids", + "ba", + "challenge", + "capsules" ], "release_date":"2023-01-04", "publication":"\"Reversible Assembly of an Artificial Protein Nanocage Using Alkaline Earth Metal Ions\", J.Am.Chem.Soc., 145, 216-223", @@ -532244,105 +534305,105 @@ ], "subtitle":"Crystal strucutre of pd-l1 and the computationally designed dbl1_03 protein binder", "tags":[ - "immune system", - "pd-l1" + "pd-l1", + "immune system" ], "keywords":[ - "engage", - "use", - "comprehensive", - "captures", - "designed", - "generated", - "experimentally", + "affinity", + "purely", + "molecular", + "fingerprints", + "recognition", + "optimized", + "structural", + "key", + "predictions", + "framework", + "new", + "drive", + "protein", + "accurate", + "cellular", + "essential", + "networks", + "novo", + "major", + "principle", + "applications", + "10", + "paradigm", "geometric", + "life", + "knowledge", + "however", "obstacle", - "features", - "interactions", - "synthetic", - "generates", - "represent", - "networks", + "governing", + "genomic", "computationally", - "broadly", - "proof", - "however", - "affinity", - "novel", + "enabling", + "experimentally", + "overall", + "biological", + "comprehensive", "crucial", - "even", - "interaction", - "reaching", + "capture", + "targets", + "surfaces", + "approach", + "showing", "proteins", - "hypothesized", - "de", - "translational", - "processes", + "characterization", + "several", + "use", "highly", - "binders", - "recognition", - "drive", - "nanomolar", - "life", - "capture", - "essential", - "function", - "cellular", - "physical", - "biology", - "framework", - "data", - "molecular", + "proof", + "spike", + "aspects", "chemical", - "predictions", - "others", + "physical", + "features", "four", - "genomic", - "accurate", - "artificial", + "nanomolar", + "computational", "1", + "increase", "challenging", - "10", - "surfaces", - "spike", - "several", "design", - "characterization", - "applications", - "describe", - "fingerprints", - "biological", - "increase", - "key", - "structural", - "enabling", - "operating", - "governing", - "designs", - "overall", "critical", - "optimized", - "aspects", - "showing", - "mutational", - "approach", - "gap", - "novo", - "principle", - "purely", - "understand", + "binders", + "even", + "biology", + "represent", + "processes", + "engage", + "captures", + "generates", + "interaction", + "broadly", + "whereas", "proteomic", + "describe", + "reaching", + "designed", "determinants", - "protein", - "targets", - "paradigm", - "knowledge", + "others", + "mutational", + "de", + "understand", + "translational", + "synthetic", + "interactions", + "function", "understanding", - "computational", "silico", - "major", - "new", - "whereas" + "artificial", + "operating", + "generated", + "gap", + "data", + "designs", + "hypothesized", + "novel" ], "release_date":"2023-04-12", "publication":"\"De novo design of protein interactions with learned surface fingerprints\", Nature, 617, 176-184", @@ -532376,10 +534437,6 @@ ], "seq_thr_sim_natural":[ - { - "sim":201.0, - "partner":"3s0f" - }, { "sim":201.0, "partner":"3rzs" @@ -532400,6 +534457,10 @@ "sim":201.0, "partner":"3s0e" }, + { + "sim":201.0, + "partner":"3s0f" + }, { "sim":194.0, "partner":"3s0g" @@ -532416,7 +534477,7 @@ ], "seq_max_sim_natural":{ "sim":201.0, - "partner":"3s0f" + "partner":"3rzs" }, "struct_max_sim_designed":{ "sim":0.4101999998, @@ -532506,10 +534567,10 @@ ], "subtitle":"Crystal structure of mettl9 in complex with slc39a5 peptide and sah", "tags":[ + "transferase", "slc39a5", "mettl9", - "histidine methyltransferase", - "transferase" + "histidine methyltransferase" ], "keywords":[ "description", @@ -532677,14 +534738,14 @@ "subtitle":"Crystal structure of a heterochiral protein complex", "tags":[ "heterochiral", - "d-peptide", "d-protein", + "de novo", "de novo protein", + "miniprotein", "alpha helix", - "de novo", + "mirror-image", "designer", - "miniprotein", - "mirror-image" + "d-peptide" ], "keywords":[ "description", @@ -532828,119 +534889,119 @@ ], "subtitle":"Crystal structure of p63 dbd in complex with darpin c14", "tags":[ - "tp63", + "sgc", "darpin", - "structural genomics", "structural genomics consortium", + "p63", + "structural genomics", "dna binding protein", - "sgc", - "p63" + "tp63" ], "keywords":[ - "domain", - "evidence", - "genetic", - "providing", - "thus", - "roles", - "regulated", - "designed", + "isoform", + "individual", "allow", - "determine", - "reactivated", + "organic", + "structural", + "repeat", "show", - "versatile", - "bind", - "conformation", + "incompetent", + "well", + "regulated", + "roles", + "within", + "protein", + "pockets", "members", + "tissue", + "binding", "identifying", - "repeat", - "inhibitors", - "inhibiting", - "primary", - "modulation", - "\u03b4np63\u03b1", - "proteins", + "domains", + "transcription", + "special", + "deep", + "conformation", + "p53", + "furthermore", + "overall", + "selected", "dna", - "cell", - "specifically", + "thus", "family", - "isoform", + "factors", + "folded", + "bind", + "transcriptional", + "proteins", + "sites", + "evidence", + "characterization", + "several", + "factor", + "ankyrin", "small", - "used", - "tap63\u03b1", - "difficult", - "targeted", - "easily", + "contain", + "tight", + "studying", + "investigate", + "lack", + "inhibiting", + "p73", + "intracellular", "binders", - "promoter", + "used", "suggests", + "research", + "reactivated", + "domain", + "addition", + "tool", + "stabilizes", + "also", + "easily", + "p63", + "cell", + "oligomerization", + "constitute", + "sterile", "detect", + "primary", "ability", - "folded", - "furthermore", - "stabilizes", + "selectively", + "plasticity", + "versatile", "competes", + "developed", + "inhibition", + "describe", + "determine", + "darpins", + "culture", + "designed", + "dependent", + "one", + "targeted", + "specificities", + "providing", + "loop", "feedback", - "individual", - "pockets", + "tap63\u03b1", + "\u03b4np63\u03b1", + "specifically", + "powerful", + "modulation", + "inhibitors", "function", - "research", + "procedures", "molecules", - "investigate", - "special", - "powerful", - "tissue", - "factors", - "oligomerization", - "incompetent", - "darpins", - "specificities", "transcriptionally", - "p63", + "high", "activity", - "p73", - "organic", - "several", - "characterization", - "selectively", "negative", - "describe", - "high", - "sterile", - "structural", - "selected", - "sites", - "factor", - "procedures", - "overall", - "one", - "lack", - "also", - "p53", - "tight", - "intracellular", - "well", - "ankyrin", - "affinities", - "culture", - "transcriptional", - "studying", - "constitute", - "addition", - "domains", - "inhibition", - "transcription", - "protein", - "dependent", - "within", - "deep", - "binding", - "developed", - "loop", - "contain", - "tool", - "plasticity" + "genetic", + "difficult", + "promoter", + "affinities" ], "release_date":"2022-07-06", "publication":"\"Designed Ankyrin Repeat Proteins as a tool box for analyzing p63\", Cell Death Differ., 29, 2445-2458", @@ -533033,19 +535094,19 @@ }, { "sim":256.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":256.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":256.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":256.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":256.0, @@ -533053,35 +535114,35 @@ }, { "sim":256.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":256.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":256.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":256.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":256.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":256.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":256.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":256.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":255.0, @@ -533089,7 +535150,7 @@ }, { "sim":255.0, - "partner":"4j8y" + "partner":"7dnf" }, { "sim":255.0, @@ -533097,11 +535158,11 @@ }, { "sim":255.0, - "partner":"7dnf" + "partner":"7dng" }, { "sim":255.0, - "partner":"7dng" + "partner":"4j8y" }, { "sim":254.0, @@ -533201,7 +535262,7 @@ }, { "sim":231.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":231.0, @@ -533209,7 +535270,7 @@ }, { "sim":231.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":230.0, @@ -533217,11 +535278,11 @@ }, { "sim":230.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":230.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":230.0, @@ -533257,11 +535318,11 @@ }, { "sim":207.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":207.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":204.0, @@ -533303,6 +535364,10 @@ "sim":188.0, "partner":"4gmr" }, + { + "sim":187.0, + "partner":"9glq" + }, { "sim":186.0, "partner":"4gpm" @@ -533367,11 +535432,11 @@ }, { "sim":269.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":269.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":269.0, @@ -533431,7 +535496,7 @@ }, { "sim":256.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":256.0, @@ -533439,11 +535504,11 @@ }, { "sim":256.0, - "partner":"6mze" + "partner":"7z02" }, { "sim":256.0, - "partner":"7z02" + "partner":"7ac5" }, { "sim":256.0, @@ -533451,11 +535516,11 @@ }, { "sim":256.0, - "partner":"7ac5" + "partner":"4lnu" }, { "sim":256.0, - "partner":"4lnu" + "partner":"6zwb" }, { "sim":256.0, @@ -533469,10 +535534,6 @@ "sim":256.0, "partner":"5nm5" }, - { - "sim":256.0, - "partner":"6zwb" - }, { "sim":256.0, "partner":"4f6r" @@ -533485,6 +535546,10 @@ "sim":256.0, "partner":"4hna" }, + { + "sim":256.0, + "partner":"7z01" + }, { "sim":256.0, "partner":"4hrl" @@ -533543,11 +535608,11 @@ }, { "sim":252.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":252.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":252.0, @@ -533645,45 +535710,25 @@ "sim":244.0, "partner":"6ob5" }, - { - "sim":244.0, - "partner":"5eno" - }, - { - "sim":244.0, - "partner":"6zob" - }, - { - "sim":244.0, - "partner":"6zo5" - }, { "sim":244.0, "partner":"4dx6" }, { "sim":244.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":244.0, "partner":"6zoc" }, - { - "sim":244.0, - "partner":"5enp" - }, - { - "sim":244.0, - "partner":"6sgs" - }, { "sim":244.0, "partner":"6zo6" }, { "sim":244.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":244.0, @@ -533691,7 +535736,7 @@ }, { "sim":244.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":244.0, @@ -533699,11 +535744,11 @@ }, { "sim":244.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":244.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":244.0, @@ -533713,6 +535758,10 @@ "sim":244.0, "partner":"6zoe" }, + { + "sim":244.0, + "partner":"5enq" + }, { "sim":244.0, "partner":"6q4p" @@ -533723,19 +535772,19 @@ }, { "sim":244.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":244.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":244.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":244.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":244.0, @@ -533747,23 +535796,23 @@ }, { "sim":244.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":244.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":244.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":244.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":244.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":244.0, @@ -533775,15 +535824,15 @@ }, { "sim":244.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":244.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":244.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":244.0, @@ -533791,15 +535840,19 @@ }, { "sim":244.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":244.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":244.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":244.0, + "partner":"6sgr" }, { "sim":244.0, @@ -533815,12 +535868,24 @@ }, { "sim":244.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":244.0, "partner":"4dx5" }, + { + "sim":244.0, + "partner":"5eno" + }, + { + "sim":244.0, + "partner":"6zo5" + }, + { + "sim":244.0, + "partner":"6q4n" + }, { "sim":244.0, "partner":"7mxi" @@ -533915,11 +535980,11 @@ }, { "sim":234.0, - "partner":"4jb8" + "partner":"5mbl" }, { "sim":234.0, - "partner":"5mbl" + "partner":"4jb8" }, { "sim":233.0, @@ -533927,11 +535992,11 @@ }, { "sim":230.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":230.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":230.0, @@ -533959,11 +536024,11 @@ }, { "sim":218.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":218.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":216.0, @@ -533977,10 +536042,6 @@ "sim":212.0, "partner":"6moi" }, - { - "sim":208.0, - "partner":"7pd8" - }, { "sim":208.0, "partner":"7pdd" @@ -533993,6 +536054,10 @@ "sim":208.0, "partner":"7pdh" }, + { + "sim":208.0, + "partner":"7pd8" + }, { "sim":204.0, "partner":"6mzg" @@ -534197,10 +536262,6 @@ "sim":109.0, "partner":"5y4f" }, - { - "sim":108.0, - "partner":"5vhj" - }, { "sim":108.0, "partner":"5vhh" @@ -534231,16 +536292,20 @@ }, { "sim":108.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":108.0, - "partner":"1uoh" + "partner":"5vhp" }, { "sim":108.0, "partner":"7vo6" }, + { + "sim":108.0, + "partner":"1uoh" + }, { "sim":108.0, "partner":"5vhi" @@ -534259,15 +536324,15 @@ }, { "sim":108.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":108.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":108.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":108.0, @@ -534327,11 +536392,11 @@ }, { "sim":99.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":99.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":98.0, @@ -534391,11 +536456,11 @@ }, { "sim":97.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":97.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":97.0, @@ -534485,10 +536550,6 @@ "sim":85.0, "partner":"4ot9" }, - { - "sim":85.0, - "partner":"6v9x" - }, { "sim":85.0, "partner":"6v9y" @@ -534501,6 +536562,10 @@ "sim":85.0, "partner":"6v9w" }, + { + "sim":85.0, + "partner":"6v9x" + }, { "sim":85.0, "partner":"7or0" @@ -534527,19 +536592,19 @@ }, { "sim":84.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":84.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":84.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":84.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":84.0, @@ -534651,11 +536716,11 @@ }, { "sim":80.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":80.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":80.0, @@ -534689,14 +536754,6 @@ "sim":78.0, "partner":"1wg0" }, - { - "sim":78.0, - "partner":"6m11" - }, - { - "sim":78.0, - "partner":"6m12" - }, { "sim":78.0, "partner":"6m13" @@ -534721,6 +536778,14 @@ "sim":78.0, "partner":"4o1p" }, + { + "sim":78.0, + "partner":"6m11" + }, + { + "sim":78.0, + "partner":"6m12" + }, { "sim":77.0, "partner":"1d9s" @@ -534769,10 +536834,6 @@ "sim":73.0, "partner":"2rfa" }, - { - "sim":73.0, - "partner":"6o1p" - }, { "sim":73.0, "partner":"6b5v" @@ -534811,7 +536872,7 @@ }, { "sim":73.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":73.0, @@ -534846,12 +536907,12 @@ "partner":"7t6l" }, { - "sim":72.0, - "partner":"5wo6" + "sim":73.0, + "partner":"7t6m" }, { "sim":72.0, - "partner":"5iwr" + "partner":"5wo6" }, { "sim":72.0, @@ -534905,6 +536966,10 @@ "sim":72.0, "partner":"5iwp" }, + { + "sim":72.0, + "partner":"5iwr" + }, { "sim":72.0, "partner":"5wo7" @@ -534953,10 +537018,6 @@ "sim":63.0, "partner":"4hbd" }, - { - "sim":63.0, - "partner":"7k4a" - }, { "sim":63.0, "partner":"7k4b" @@ -534979,7 +537040,7 @@ }, { "sim":63.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":63.0, @@ -534995,11 +537056,11 @@ }, { "sim":63.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":63.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":63.0, @@ -535017,6 +537078,10 @@ "sim":63.0, "partner":"6bo8" }, + { + "sim":63.0, + "partner":"6bo9" + }, { "sim":61.0, "partner":"6sku" @@ -535089,10 +537154,6 @@ "sim":57.0, "partner":"5is0" }, - { - "sim":57.0, - "partner":"7mzc" - }, { "sim":57.0, "partner":"7l2v" @@ -535155,7 +537216,7 @@ }, { "sim":57.0, - "partner":"7l2n" + "partner":"7mzc" }, { "sim":57.0, @@ -535191,32 +537252,28 @@ }, { "sim":57.0, - "partner":"7lqy" + "partner":"7l2n" }, { "sim":57.0, - "partner":"7lqz" + "partner":"7lqy" }, { "sim":57.0, - "partner":"7lr0" + "partner":"7lqz" }, { "sim":57.0, - "partner":"7lpd" + "partner":"7lr0" }, { "sim":57.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":57.0, "partner":"7rqv" }, - { - "sim":57.0, - "partner":"7lpe" - }, { "sim":57.0, "partner":"7rqw" @@ -535249,6 +537306,14 @@ "sim":57.0, "partner":"7lpc" }, + { + "sim":57.0, + "partner":"7rqu" + }, + { + "sim":57.0, + "partner":"7lpd" + }, { "sim":56.0, "partner":"4ber" @@ -535273,10 +537338,6 @@ "sim":50.0, "partner":"6lgp" }, - { - "sim":50.0, - "partner":"6dvz" - }, { "sim":50.0, "partner":"6dvw" @@ -535287,19 +537348,11 @@ }, { "sim":50.0, - "partner":"6pvo" - }, - { - "sim":50.0, - "partner":"7mij" - }, - { - "sim":50.0, - "partner":"6pvp" + "partner":"6dvz" }, { "sim":50.0, - "partner":"7ras" + "partner":"6pvq" }, { "sim":50.0, @@ -535307,7 +537360,7 @@ }, { "sim":50.0, - "partner":"6pvq" + "partner":"7ras" }, { "sim":50.0, @@ -535321,13 +537374,17 @@ "sim":50.0, "partner":"7mim" }, + { + "sim":50.0, + "partner":"6pvl" + }, { "sim":50.0, "partner":"7min" }, { "sim":50.0, - "partner":"6pvl" + "partner":"6pvm" }, { "sim":50.0, @@ -535339,11 +537396,19 @@ }, { "sim":50.0, - "partner":"6pvm" + "partner":"6pvn" }, { "sim":50.0, - "partner":"6pvn" + "partner":"6pvo" + }, + { + "sim":50.0, + "partner":"6pvp" + }, + { + "sim":50.0, + "partner":"7mij" } ], "struct_thr_sim_designed":[ @@ -535738,119 +537803,119 @@ ], "subtitle":"Crystal structure of p63 sam in complex with darpin a5", "tags":[ - "tp63", + "sgc", "darpin", - "structural genomics", "structural genomics consortium", + "p63", + "structural genomics", "dna binding protein", - "sgc", - "p63" + "tp63" ], "keywords":[ - "domain", - "evidence", - "genetic", - "providing", - "thus", - "roles", - "regulated", - "designed", + "isoform", + "individual", "allow", - "determine", - "reactivated", + "organic", + "structural", + "repeat", "show", - "versatile", - "bind", - "conformation", + "incompetent", + "well", + "regulated", + "roles", + "within", + "protein", + "pockets", "members", + "tissue", + "binding", "identifying", - "repeat", - "inhibitors", - "inhibiting", - "primary", - "modulation", - "\u03b4np63\u03b1", - "proteins", + "domains", + "transcription", + "special", + "deep", + "conformation", + "p53", + "furthermore", + "overall", + "selected", "dna", - "cell", - "specifically", + "thus", "family", - "isoform", + "factors", + "folded", + "bind", + "transcriptional", + "proteins", + "sites", + "evidence", + "characterization", + "several", + "factor", + "ankyrin", "small", - "used", - "tap63\u03b1", - "difficult", - "targeted", - "easily", + "contain", + "tight", + "studying", + "investigate", + "lack", + "inhibiting", + "p73", + "intracellular", "binders", - "promoter", + "used", "suggests", + "research", + "reactivated", + "domain", + "addition", + "tool", + "stabilizes", + "also", + "easily", + "p63", + "cell", + "oligomerization", + "constitute", + "sterile", "detect", + "primary", "ability", - "folded", - "furthermore", - "stabilizes", + "selectively", + "plasticity", + "versatile", "competes", + "developed", + "inhibition", + "describe", + "determine", + "darpins", + "culture", + "designed", + "dependent", + "one", + "targeted", + "specificities", + "providing", + "loop", "feedback", - "individual", - "pockets", + "tap63\u03b1", + "\u03b4np63\u03b1", + "specifically", + "powerful", + "modulation", + "inhibitors", "function", - "research", + "procedures", "molecules", - "investigate", - "special", - "powerful", - "tissue", - "factors", - "oligomerization", - "incompetent", - "darpins", - "specificities", "transcriptionally", - "p63", + "high", "activity", - "p73", - "organic", - "several", - "characterization", - "selectively", "negative", - "describe", - "high", - "sterile", - "structural", - "selected", - "sites", - "factor", - "procedures", - "overall", - "one", - "lack", - "also", - "p53", - "tight", - "intracellular", - "well", - "ankyrin", - "affinities", - "culture", - "transcriptional", - "studying", - "constitute", - "addition", - "domains", - "inhibition", - "transcription", - "protein", - "dependent", - "within", - "deep", - "binding", - "developed", - "loop", - "contain", - "tool", - "plasticity" + "genetic", + "difficult", + "promoter", + "affinities" ], "release_date":"2022-07-06", "publication":"\"Designed Ankyrin Repeat Proteins as a tool box for analyzing p63\", Cell Death Differ., 29, 2445-2458", @@ -535931,19 +537996,19 @@ }, { "sim":261.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":261.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":261.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":261.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":261.0, @@ -535951,35 +538016,35 @@ }, { "sim":261.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":261.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":261.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":261.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":261.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":261.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":261.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":261.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":260.0, @@ -536007,11 +538072,11 @@ }, { "sim":258.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":258.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":257.0, @@ -536031,11 +538096,11 @@ }, { "sim":254.0, - "partner":"8a1a" + "partner":"8a19" }, { "sim":254.0, - "partner":"8a19" + "partner":"8a1a" }, { "sim":251.0, @@ -536099,7 +538164,7 @@ }, { "sim":237.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":237.0, @@ -536107,7 +538172,7 @@ }, { "sim":237.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":236.0, @@ -536147,11 +538212,11 @@ }, { "sim":219.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":219.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":219.0, @@ -536183,11 +538248,11 @@ }, { "sim":197.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":197.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":194.0, @@ -536201,6 +538266,10 @@ "sim":192.0, "partner":"4o60" }, + { + "sim":185.0, + "partner":"9glq" + }, { "sim":185.0, "partner":"8ak1" @@ -536293,11 +538362,11 @@ }, { "sim":263.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":263.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":263.0, @@ -536335,17 +538404,13 @@ "sim":261.0, "partner":"6bbn" }, - { - "sim":261.0, - "partner":"5oyj" - }, { "sim":261.0, "partner":"6mzf" }, { "sim":261.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":261.0, @@ -536353,11 +538418,11 @@ }, { "sim":261.0, - "partner":"6mze" + "partner":"7z02" }, { "sim":261.0, - "partner":"7z02" + "partner":"7ac5" }, { "sim":261.0, @@ -536365,11 +538430,11 @@ }, { "sim":261.0, - "partner":"7ac5" + "partner":"4lnu" }, { "sim":261.0, - "partner":"4lnu" + "partner":"6zwb" }, { "sim":261.0, @@ -536385,11 +538450,15 @@ }, { "sim":261.0, - "partner":"6zwb" + "partner":"6zwc" }, { "sim":261.0, - "partner":"6zwc" + "partner":"5oyj" + }, + { + "sim":261.0, + "partner":"7z01" }, { "sim":261.0, @@ -536459,25 +538528,13 @@ "sim":258.0, "partner":"4hrl" }, - { - "sim":257.0, - "partner":"7pjf" - }, { "sim":257.0, "partner":"6s8l" }, { "sim":257.0, - "partner":"5eno" - }, - { - "sim":257.0, - "partner":"6zob" - }, - { - "sim":257.0, - "partner":"6zo5" + "partner":"7pjf" }, { "sim":257.0, @@ -536485,27 +538542,19 @@ }, { "sim":257.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":257.0, "partner":"6zoc" }, - { - "sim":257.0, - "partner":"5enp" - }, - { - "sim":257.0, - "partner":"6sgs" - }, { "sim":257.0, "partner":"6zo6" }, { "sim":257.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":257.0, @@ -536513,7 +538562,7 @@ }, { "sim":257.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":257.0, @@ -536521,11 +538570,11 @@ }, { "sim":257.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":257.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":257.0, @@ -536535,6 +538584,10 @@ "sim":257.0, "partner":"6zoe" }, + { + "sim":257.0, + "partner":"5enq" + }, { "sim":257.0, "partner":"6q4p" @@ -536545,19 +538598,19 @@ }, { "sim":257.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":257.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":257.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":257.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":257.0, @@ -536569,23 +538622,23 @@ }, { "sim":257.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":257.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":257.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":257.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":257.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":257.0, @@ -536597,15 +538650,15 @@ }, { "sim":257.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":257.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":257.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":257.0, @@ -536613,15 +538666,19 @@ }, { "sim":257.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":257.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":257.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":257.0, + "partner":"6sgr" }, { "sim":257.0, @@ -536637,12 +538694,24 @@ }, { "sim":257.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":257.0, "partner":"4dx5" }, + { + "sim":257.0, + "partner":"5eno" + }, + { + "sim":257.0, + "partner":"6zo5" + }, + { + "sim":257.0, + "partner":"6q4n" + }, { "sim":256.0, "partner":"3zu7" @@ -536833,11 +538902,11 @@ }, { "sim":231.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":231.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":230.0, @@ -536869,11 +538938,11 @@ }, { "sim":218.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":218.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":218.0, @@ -536891,10 +538960,6 @@ "sim":206.0, "partner":"5itz" }, - { - "sim":204.0, - "partner":"7pd8" - }, { "sim":204.0, "partner":"7pdd" @@ -536907,6 +538972,10 @@ "sim":204.0, "partner":"7pdh" }, + { + "sim":204.0, + "partner":"7pd8" + }, { "sim":202.0, "partner":"6mzg" @@ -537079,10 +539148,6 @@ "sim":114.0, "partner":"3twq" }, - { - "sim":112.0, - "partner":"5vhj" - }, { "sim":112.0, "partner":"5vhh" @@ -537113,16 +539178,20 @@ }, { "sim":112.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":112.0, - "partner":"1uoh" + "partner":"5vhp" }, { "sim":112.0, "partner":"7vo6" }, + { + "sim":112.0, + "partner":"1uoh" + }, { "sim":112.0, "partner":"5vhi" @@ -537141,15 +539210,15 @@ }, { "sim":112.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":112.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":112.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":112.0, @@ -537213,11 +539282,11 @@ }, { "sim":101.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":101.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":99.0, @@ -537265,11 +539334,11 @@ }, { "sim":94.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":94.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":94.0, @@ -537479,14 +539548,6 @@ "sim":84.0, "partner":"6jd6" }, - { - "sim":84.0, - "partner":"6m11" - }, - { - "sim":84.0, - "partner":"6m12" - }, { "sim":84.0, "partner":"6m13" @@ -537512,12 +539573,12 @@ "partner":"4o1p" }, { - "sim":83.0, - "partner":"3aaa" + "sim":84.0, + "partner":"6m11" }, { - "sim":83.0, - "partner":"7dsb" + "sim":84.0, + "partner":"6m12" }, { "sim":83.0, @@ -537527,6 +539588,14 @@ "sim":83.0, "partner":"7dsa" }, + { + "sim":83.0, + "partner":"7dsb" + }, + { + "sim":83.0, + "partner":"3aaa" + }, { "sim":83.0, "partner":"5ja4" @@ -537615,10 +539684,6 @@ "sim":76.0, "partner":"6kyk" }, - { - "sim":76.0, - "partner":"6v9x" - }, { "sim":76.0, "partner":"6v9y" @@ -537631,6 +539696,10 @@ "sim":76.0, "partner":"6v9w" }, + { + "sim":76.0, + "partner":"6v9x" + }, { "sim":76.0, "partner":"7or0" @@ -537733,11 +539802,11 @@ }, { "sim":72.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":72.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":71.0, @@ -537771,10 +539840,6 @@ "sim":69.0, "partner":"4hbd" }, - { - "sim":68.0, - "partner":"2a5e" - }, { "sim":68.0, "partner":"1dc2" @@ -537784,12 +539849,12 @@ "partner":"1a5e" }, { - "sim":67.0, - "partner":"5wo6" + "sim":68.0, + "partner":"2a5e" }, { "sim":67.0, - "partner":"5iwr" + "partner":"5wo6" }, { "sim":67.0, @@ -537843,6 +539908,10 @@ "sim":67.0, "partner":"5iwp" }, + { + "sim":67.0, + "partner":"5iwr" + }, { "sim":67.0, "partner":"5wo7" @@ -537859,10 +539928,6 @@ "sim":66.0, "partner":"3ui2" }, - { - "sim":65.0, - "partner":"6o1p" - }, { "sim":65.0, "partner":"6b5v" @@ -537901,7 +539966,7 @@ }, { "sim":65.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":65.0, @@ -537935,6 +540000,10 @@ "sim":65.0, "partner":"7t6l" }, + { + "sim":65.0, + "partner":"7t6m" + }, { "sim":63.0, "partner":"1k3z" @@ -537955,10 +540024,6 @@ "sim":61.0, "partner":"6mca" }, - { - "sim":61.0, - "partner":"7k4a" - }, { "sim":61.0, "partner":"7k4b" @@ -537981,7 +540046,7 @@ }, { "sim":61.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":61.0, @@ -537997,11 +540062,11 @@ }, { "sim":61.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":61.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":61.0, @@ -538019,6 +540084,10 @@ "sim":61.0, "partner":"6bo8" }, + { + "sim":61.0, + "partner":"6bo9" + }, { "sim":60.0, "partner":"6sku" @@ -538111,10 +540180,6 @@ "sim":54.0, "partner":"5is0" }, - { - "sim":54.0, - "partner":"7mzc" - }, { "sim":54.0, "partner":"7l2v" @@ -538177,7 +540242,7 @@ }, { "sim":54.0, - "partner":"7l2n" + "partner":"7mzc" }, { "sim":54.0, @@ -538213,32 +540278,28 @@ }, { "sim":54.0, - "partner":"7lqy" + "partner":"7l2n" }, { "sim":54.0, - "partner":"7lqz" + "partner":"7lqy" }, { "sim":54.0, - "partner":"7lr0" + "partner":"7lqz" }, { "sim":54.0, - "partner":"7lpd" + "partner":"7lr0" }, { "sim":54.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":54.0, "partner":"7rqv" }, - { - "sim":54.0, - "partner":"7lpe" - }, { "sim":54.0, "partner":"7rqw" @@ -538272,40 +540333,36 @@ "partner":"7lpc" }, { - "sim":53.0, - "partner":"4n5q" - }, - { - "sim":53.0, - "partner":"6lgp" + "sim":54.0, + "partner":"7rqu" }, { - "sim":53.0, - "partner":"6dvz" + "sim":54.0, + "partner":"7lpd" }, { "sim":53.0, - "partner":"6dvw" + "partner":"4n5q" }, { "sim":53.0, - "partner":"6dvy" + "partner":"6lgp" }, { "sim":53.0, - "partner":"6pvo" + "partner":"6dvw" }, { "sim":53.0, - "partner":"7mij" + "partner":"6dvy" }, { "sim":53.0, - "partner":"6pvp" + "partner":"6dvz" }, { "sim":53.0, - "partner":"7ras" + "partner":"6pvq" }, { "sim":53.0, @@ -538313,7 +540370,7 @@ }, { "sim":53.0, - "partner":"6pvq" + "partner":"7ras" }, { "sim":53.0, @@ -538327,13 +540384,17 @@ "sim":53.0, "partner":"7mim" }, + { + "sim":53.0, + "partner":"6pvl" + }, { "sim":53.0, "partner":"7min" }, { "sim":53.0, - "partner":"6pvl" + "partner":"6pvm" }, { "sim":53.0, @@ -538345,11 +540406,19 @@ }, { "sim":53.0, - "partner":"6pvm" + "partner":"6pvn" }, { "sim":53.0, - "partner":"6pvn" + "partner":"6pvo" + }, + { + "sim":53.0, + "partner":"6pvp" + }, + { + "sim":53.0, + "partner":"7mij" }, { "sim":50.0, @@ -538632,119 +540701,119 @@ ], "subtitle":"Crystal structure of p63 tetramerization domain in complex with darpin 8f1", "tags":[ - "tp63", + "sgc", "darpin", - "structural genomics", "structural genomics consortium", + "p63", + "structural genomics", "dna binding protein", - "sgc", - "p63" + "tp63" ], "keywords":[ - "domain", - "evidence", - "genetic", - "providing", - "thus", - "roles", - "regulated", - "designed", + "isoform", + "individual", "allow", - "determine", - "reactivated", + "organic", + "structural", + "repeat", "show", - "versatile", - "bind", - "conformation", + "incompetent", + "well", + "regulated", + "roles", + "within", + "protein", + "pockets", "members", + "tissue", + "binding", "identifying", - "repeat", - "inhibitors", - "inhibiting", - "primary", - "modulation", - "\u03b4np63\u03b1", - "proteins", + "domains", + "transcription", + "special", + "deep", + "conformation", + "p53", + "furthermore", + "overall", + "selected", "dna", - "cell", - "specifically", + "thus", "family", - "isoform", + "factors", + "folded", + "bind", + "transcriptional", + "proteins", + "sites", + "evidence", + "characterization", + "several", + "factor", + "ankyrin", "small", - "used", - "tap63\u03b1", - "difficult", - "targeted", - "easily", + "contain", + "tight", + "studying", + "investigate", + "lack", + "inhibiting", + "p73", + "intracellular", "binders", - "promoter", + "used", "suggests", + "research", + "reactivated", + "domain", + "addition", + "tool", + "stabilizes", + "also", + "easily", + "p63", + "cell", + "oligomerization", + "constitute", + "sterile", "detect", + "primary", "ability", - "folded", - "furthermore", - "stabilizes", + "selectively", + "plasticity", + "versatile", "competes", + "developed", + "inhibition", + "describe", + "determine", + "darpins", + "culture", + "designed", + "dependent", + "one", + "targeted", + "specificities", + "providing", + "loop", "feedback", - "individual", - "pockets", + "tap63\u03b1", + "\u03b4np63\u03b1", + "specifically", + "powerful", + "modulation", + "inhibitors", "function", - "research", + "procedures", "molecules", - "investigate", - "special", - "powerful", - "tissue", - "factors", - "oligomerization", - "incompetent", - "darpins", - "specificities", "transcriptionally", - "p63", + "high", "activity", - "p73", - "organic", - "several", - "characterization", - "selectively", "negative", - "describe", - "high", - "sterile", - "structural", - "selected", - "sites", - "factor", - "procedures", - "overall", - "one", - "lack", - "also", - "p53", - "tight", - "intracellular", - "well", - "ankyrin", - "affinities", - "culture", - "transcriptional", - "studying", - "constitute", - "addition", - "domains", - "inhibition", - "transcription", - "protein", - "dependent", - "within", - "deep", - "binding", - "developed", - "loop", - "contain", - "tool", - "plasticity" + "genetic", + "difficult", + "promoter", + "affinities" ], "release_date":"2022-07-06", "publication":"\"Designed Ankyrin Repeat Proteins as a tool box for analyzing p63\", Cell Death Differ., 29, 2445-2458", @@ -538781,11 +540850,11 @@ }, { "sim":227.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":227.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":219.0, @@ -538859,6 +540928,10 @@ "sim":201.0, "partner":"8aiw" }, + { + "sim":199.0, + "partner":"9glq" + }, { "sim":199.0, "partner":"2xee" @@ -538889,43 +540962,43 @@ }, { "sim":197.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":197.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":197.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":197.0, - "partner":"4dui" + "partner":"8qla" }, { "sim":197.0, - "partner":"8ql9" + "partner":"8ql8" }, { "sim":197.0, - "partner":"8ql8" + "partner":"4dui" }, { "sim":197.0, - "partner":"8ql3" + "partner":"8qea" }, { "sim":197.0, - "partner":"9f8g" + "partner":"8qlb" }, { "sim":197.0, - "partner":"8ql6" + "partner":"8ql9" }, { "sim":197.0, - "partner":"8ql5" + "partner":"8ql7" }, { "sim":197.0, @@ -538933,15 +541006,15 @@ }, { "sim":197.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":197.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":197.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":196.0, @@ -538953,11 +541026,11 @@ }, { "sim":196.0, - "partner":"5lw2" + "partner":"5knh" }, { "sim":196.0, - "partner":"5knh" + "partner":"5lw2" }, { "sim":196.0, @@ -538985,11 +541058,11 @@ }, { "sim":191.0, - "partner":"7dne" + "partner":"2xeh" }, { "sim":191.0, - "partner":"2xeh" + "partner":"7dne" }, { "sim":191.0, @@ -539037,11 +541110,11 @@ }, { "sim":187.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":187.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":187.0, @@ -539049,7 +541122,7 @@ }, { "sim":187.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":187.0, @@ -539057,7 +541130,7 @@ }, { "sim":187.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":186.0, @@ -539145,10 +541218,6 @@ } ], "seq_thr_sim_natural":[ - { - "sim":230.0, - "partner":"7pd8" - }, { "sim":230.0, "partner":"7pdd" @@ -539161,6 +541230,10 @@ "sim":230.0, "partner":"7pdh" }, + { + "sim":230.0, + "partner":"7pd8" + }, { "sim":228.0, "partner":"6fp7" @@ -539187,15 +541260,15 @@ }, { "sim":210.0, - "partner":"4hrm" + "partner":"5fin" }, { "sim":210.0, - "partner":"5fin" + "partner":"5fio" }, { "sim":210.0, - "partner":"5fio" + "partner":"4hrm" }, { "sim":210.0, @@ -539231,11 +541304,11 @@ }, { "sim":208.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":208.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":208.0, @@ -539271,15 +541344,15 @@ }, { "sim":204.0, - "partner":"6d66" + "partner":"2xzd" }, { "sim":204.0, - "partner":"6d67" + "partner":"6d66" }, { "sim":204.0, - "partner":"2xzd" + "partner":"6d67" }, { "sim":204.0, @@ -539291,15 +541364,15 @@ }, { "sim":203.0, - "partner":"5oyj" + "partner":"3nog" }, { "sim":203.0, - "partner":"3nog" + "partner":"4k5a" }, { "sim":203.0, - "partner":"4k5a" + "partner":"5oyj" }, { "sim":203.0, @@ -539353,45 +541426,25 @@ "sim":199.0, "partner":"6ob5" }, - { - "sim":199.0, - "partner":"5eno" - }, - { - "sim":199.0, - "partner":"6zob" - }, - { - "sim":199.0, - "partner":"6zo5" - }, { "sim":199.0, "partner":"4dx6" }, { "sim":199.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":199.0, "partner":"6zoc" }, - { - "sim":199.0, - "partner":"5enp" - }, - { - "sim":199.0, - "partner":"6sgs" - }, { "sim":199.0, "partner":"6zo6" }, { "sim":199.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":199.0, @@ -539399,7 +541452,7 @@ }, { "sim":199.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":199.0, @@ -539407,11 +541460,11 @@ }, { "sim":199.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":199.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":199.0, @@ -539421,6 +541474,10 @@ "sim":199.0, "partner":"6zoe" }, + { + "sim":199.0, + "partner":"5enq" + }, { "sim":199.0, "partner":"6q4p" @@ -539429,6 +541486,10 @@ "sim":199.0, "partner":"6sgt" }, + { + "sim":199.0, + "partner":"7b8s" + }, { "sim":199.0, "partner":"7ouk" @@ -539443,19 +541504,19 @@ }, { "sim":199.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":199.0, - "partner":"3noc" + "partner":"6zof" }, { "sim":199.0, - "partner":"6zo8" + "partner":"3noc" }, { "sim":199.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":199.0, @@ -539463,31 +541524,31 @@ }, { "sim":199.0, - "partner":"4u8v" + "partner":"7oul" }, { "sim":199.0, - "partner":"6sgu" + "partner":"4u8v" }, { "sim":199.0, - "partner":"7oul" + "partner":"7b8t" }, { "sim":199.0, - "partner":"5nc5" + "partner":"6zo9" }, { "sim":199.0, - "partner":"6zo9" + "partner":"6zog" }, { "sim":199.0, - "partner":"6zog" + "partner":"5nc5" }, { "sim":199.0, - "partner":"7b8t" + "partner":"7oum" }, { "sim":199.0, @@ -539495,23 +541556,23 @@ }, { "sim":199.0, - "partner":"7oum" + "partner":"5en5" }, { "sim":199.0, - "partner":"5en5" + "partner":"6zoa" }, { "sim":199.0, - "partner":"4u8y" + "partner":"6zoh" }, { "sim":199.0, - "partner":"6zoa" + "partner":"4u8y" }, { "sim":199.0, - "partner":"6zoh" + "partner":"6sgr" }, { "sim":199.0, @@ -539527,12 +541588,24 @@ }, { "sim":199.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":199.0, "partner":"4dx5" }, + { + "sim":199.0, + "partner":"5eno" + }, + { + "sim":199.0, + "partner":"6zo5" + }, + { + "sim":199.0, + "partner":"6q4n" + }, { "sim":199.0, "partner":"5cbn" @@ -539563,7 +541636,7 @@ }, { "sim":197.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":197.0, @@ -539571,11 +541644,11 @@ }, { "sim":197.0, - "partner":"6mze" + "partner":"7z02" }, { "sim":197.0, - "partner":"7z02" + "partner":"7ac5" }, { "sim":197.0, @@ -539587,11 +541660,11 @@ }, { "sim":197.0, - "partner":"7ac5" + "partner":"4lnu" }, { "sim":197.0, - "partner":"4lnu" + "partner":"6zwb" }, { "sim":197.0, @@ -539607,11 +541680,11 @@ }, { "sim":197.0, - "partner":"6zwb" + "partner":"6zwc" }, { "sim":197.0, - "partner":"6zwc" + "partner":"7z01" }, { "sim":197.0, @@ -539635,11 +541708,11 @@ }, { "sim":196.0, - "partner":"2y1l" + "partner":"6gvm" }, { "sim":196.0, - "partner":"6gvm" + "partner":"2y1l" }, { "sim":196.0, @@ -539715,11 +541788,11 @@ }, { "sim":192.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":192.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":192.0, @@ -539823,11 +541896,11 @@ }, { "sim":178.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":178.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":176.0, @@ -539859,11 +541932,11 @@ }, { "sim":165.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":165.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":163.0, @@ -539999,28 +542072,24 @@ }, { "sim":87.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":87.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":87.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":87.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":87.0, "partner":"5ja4" }, - { - "sim":87.0, - "partner":"5vhj" - }, { "sim":87.0, "partner":"5vhh" @@ -540051,16 +542120,20 @@ }, { "sim":87.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":87.0, - "partner":"1uoh" + "partner":"5vhp" }, { "sim":87.0, "partner":"7vo6" }, + { + "sim":87.0, + "partner":"1uoh" + }, { "sim":87.0, "partner":"5vhi" @@ -540183,15 +542256,15 @@ }, { "sim":79.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":79.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":79.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":79.0, @@ -540223,11 +542296,11 @@ }, { "sim":77.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":77.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":76.0, @@ -540247,11 +542320,11 @@ }, { "sim":76.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":76.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":76.0, @@ -540359,15 +542432,15 @@ }, { "sim":69.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":69.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":69.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":69.0, @@ -540533,14 +542606,6 @@ "sim":62.0, "partner":"4uuc" }, - { - "sim":61.0, - "partner":"6m11" - }, - { - "sim":61.0, - "partner":"6m12" - }, { "sim":61.0, "partner":"6m13" @@ -540567,7 +542632,11 @@ }, { "sim":61.0, - "partner":"6o1p" + "partner":"6m11" + }, + { + "sim":61.0, + "partner":"6m12" }, { "sim":61.0, @@ -540607,7 +542676,7 @@ }, { "sim":61.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":61.0, @@ -540643,7 +542712,7 @@ }, { "sim":61.0, - "partner":"6v9x" + "partner":"7t6m" }, { "sim":61.0, @@ -540657,6 +542726,10 @@ "sim":61.0, "partner":"6v9w" }, + { + "sim":61.0, + "partner":"6v9x" + }, { "sim":61.0, "partner":"7or0" @@ -540713,10 +542786,6 @@ "sim":60.0, "partner":"5wo6" }, - { - "sim":60.0, - "partner":"5iwr" - }, { "sim":60.0, "partner":"5iwt" @@ -540769,6 +542838,10 @@ "sim":60.0, "partner":"5iwp" }, + { + "sim":60.0, + "partner":"5iwr" + }, { "sim":60.0, "partner":"5wo7" @@ -540869,10 +542942,6 @@ "sim":52.0, "partner":"4bet" }, - { - "sim":52.0, - "partner":"7k4a" - }, { "sim":52.0, "partner":"7k4b" @@ -540895,7 +542964,7 @@ }, { "sim":52.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":52.0, @@ -540911,11 +542980,11 @@ }, { "sim":52.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":52.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":52.0, @@ -540933,6 +543002,10 @@ "sim":52.0, "partner":"6bo8" }, + { + "sim":52.0, + "partner":"6bo9" + }, { "sim":51.0, "partner":"6dcx" @@ -540947,6 +543020,10 @@ } ], "struct_thr_sim_designed":[ + { + "sim":0.9805999994, + "partner":"9glq" + }, { "sim":0.977699995, "partner":"7b4u" @@ -541156,11 +543233,11 @@ }, "seq_max_sim_natural":{ "sim":230.0, - "partner":"7pd8" + "partner":"7pdd" }, "struct_max_sim_designed":{ - "sim":0.977699995, - "partner":"7b4u" + "sim":0.9805999994, + "partner":"9glq" }, "struct_max_sim_natural":{ "sim":0.9794999957, @@ -541298,93 +543375,93 @@ ], "subtitle":"Broadly neutralizing darpin bnd.8 in complex with the hiv-1 envelope variable loop 3 peptide v3 (bf520)", "tags":[ - "darpin", "de novo protein", - "hiv" + "hiv", + "darpin" ], "keywords":[ - "amphipathic", - "glycoprotein", "trimer", - "conserved", - "abundant", - "designed", - "indispensable", - "envelope", - "variable", - "mutation", - "masking", - "potential", - "target", - "generally", - "based", - "technology", - "access", + "open", + "molecular", + "prefusion", + "crown", "repeat", - "broadly", - "recognized", - "inhibitors", + "key", + "half", + "masking", + "via", + "within", + "protein", "solely", - "cd4", + "binding", "postattachment", - "allows", - "cell", - "neutralizing", - "escape", - "efficient", - "open", "entry", - "highlighting", - "breadth", - "reinstitute", - "dynamics", - "\u03b1v3c", - "bnds", - "v3", - "immunodeficiency", - "attachment", - "targeting", - "neutralization", - "molecular", - "functional", - "amino", - "virus", - "via", - "report", + "relevance", + "rare", + "site", "contact", - "darpins", - "1", - "acids", + "envelope", + "conformational", + "immunodeficiency", + "closed", "underscored", + "access", "trimers", + "termed", + "bound", + "generally", + "ankyrin", + "neutralization", + "bnds", "category", + "1", + "variable", "bnd", "surface", - "key", - "relevance", - "prefusion", - "rare", - "closed", - "analyses", - "conformational", - "termed", + "glycoprotein", + "functional", + "potential", + "targeting", + "third", + "virus", + "attachment", + "cell", + "cd4", + "amino", + "allows", + "highlighting", + "broadly", "90", - "human", - "half", - "ankyrin", + "technology", + "neutralizing", + "inhibition", + "indispensable", + "analyses", + "amphipathic", + "darpins", + "mutation", + "dynamics", + "recognized", + "designed", + "breadth", + "efficient", + "\u03b1v3c", + "conserved", + "loop", + "v3", + "based", "darpin", + "report", + "target", + "escape", "state", - "inhibition", - "binding", - "protein", - "bound", - "crown", - "third", - "within", + "inhibitors", + "reinstitute", + "abundant", "distinct", - "antibodies", - "site", - "loop" + "acids", + "human", + "antibodies" ], "release_date":"2023-03-29", "publication":"\"Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization\", Nat.Struct.Mol.Biol., 30, 1323-1336", @@ -541477,19 +543554,19 @@ }, { "sim":259.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":259.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":259.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":259.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":259.0, @@ -541497,35 +543574,35 @@ }, { "sim":259.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":259.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":259.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":259.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":259.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":259.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":259.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":259.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":258.0, @@ -541537,11 +543614,11 @@ }, { "sim":256.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":256.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":254.0, @@ -541637,7 +543714,7 @@ }, { "sim":240.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":240.0, @@ -541645,7 +543722,7 @@ }, { "sim":240.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":237.0, @@ -541677,11 +543754,11 @@ }, { "sim":229.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":229.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":229.0, @@ -541705,11 +543782,11 @@ }, { "sim":208.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":208.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":204.0, @@ -541735,6 +543812,10 @@ "sim":191.0, "partner":"4hqd" }, + { + "sim":190.0, + "partner":"9glq" + }, { "sim":187.0, "partner":"2jab" @@ -541831,11 +543912,11 @@ }, { "sim":265.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":265.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":265.0, @@ -541869,30 +543950,18 @@ "sim":259.0, "partner":"6bbn" }, - { - "sim":259.0, - "partner":"7yz0" - }, { "sim":259.0, "partner":"6mzf" }, { "sim":259.0, - "partner":"7yz1" - }, - { - "sim":259.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":259.0, "partner":"5nqt" }, - { - "sim":259.0, - "partner":"6mze" - }, { "sim":259.0, "partner":"7yz2" @@ -541903,11 +543972,11 @@ }, { "sim":259.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":259.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":259.0, @@ -541917,13 +543986,17 @@ "sim":259.0, "partner":"7yz5" }, + { + "sim":259.0, + "partner":"7yz6" + }, { "sim":259.0, "partner":"4lnu" }, { "sim":259.0, - "partner":"7yz6" + "partner":"6zwb" }, { "sim":259.0, @@ -541937,10 +544010,6 @@ "sim":259.0, "partner":"5nm5" }, - { - "sim":259.0, - "partner":"6zwb" - }, { "sim":259.0, "partner":"6zwc" @@ -541957,6 +544026,18 @@ "sim":259.0, "partner":"7yyz" }, + { + "sim":259.0, + "partner":"7yz0" + }, + { + "sim":259.0, + "partner":"7yz1" + }, + { + "sim":259.0, + "partner":"7z01" + }, { "sim":258.0, "partner":"5oov" @@ -541987,11 +544068,11 @@ }, { "sim":256.0, - "partner":"5oyj" + "partner":"2bkk" }, { "sim":256.0, - "partner":"2bkk" + "partner":"5oyj" }, { "sim":255.0, @@ -542023,11 +544104,11 @@ }, { "sim":254.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":254.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":254.0, @@ -542077,45 +544158,25 @@ "sim":252.0, "partner":"6h47" }, - { - "sim":251.0, - "partner":"5eno" - }, - { - "sim":251.0, - "partner":"6zob" - }, - { - "sim":251.0, - "partner":"6zo5" - }, { "sim":251.0, "partner":"4dx6" }, { "sim":251.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":251.0, "partner":"6zoc" }, - { - "sim":251.0, - "partner":"5enp" - }, - { - "sim":251.0, - "partner":"6sgs" - }, { "sim":251.0, "partner":"6zo6" }, { "sim":251.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":251.0, @@ -542123,7 +544184,7 @@ }, { "sim":251.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":251.0, @@ -542131,11 +544192,11 @@ }, { "sim":251.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":251.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":251.0, @@ -542145,6 +544206,10 @@ "sim":251.0, "partner":"6zoe" }, + { + "sim":251.0, + "partner":"5enq" + }, { "sim":251.0, "partner":"6q4p" @@ -542155,19 +544220,19 @@ }, { "sim":251.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":251.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":251.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":251.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":251.0, @@ -542179,23 +544244,23 @@ }, { "sim":251.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":251.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":251.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":251.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":251.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":251.0, @@ -542207,15 +544272,15 @@ }, { "sim":251.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":251.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":251.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":251.0, @@ -542223,15 +544288,19 @@ }, { "sim":251.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":251.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":251.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":251.0, + "partner":"6sgr" }, { "sim":251.0, @@ -542247,12 +544316,24 @@ }, { "sim":251.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":251.0, "partner":"4dx5" }, + { + "sim":251.0, + "partner":"5eno" + }, + { + "sim":251.0, + "partner":"6zo5" + }, + { + "sim":251.0, + "partner":"6q4n" + }, { "sim":251.0, "partner":"5lel" @@ -542263,11 +544344,11 @@ }, { "sim":250.0, - "partner":"6mof" + "partner":"5ooy" }, { "sim":250.0, - "partner":"5ooy" + "partner":"6mof" }, { "sim":250.0, @@ -542407,11 +544488,11 @@ }, { "sim":235.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":235.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":235.0, @@ -542463,20 +544544,16 @@ }, { "sim":221.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":221.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":220.0, "partner":"6moi" }, - { - "sim":216.0, - "partner":"7pd8" - }, { "sim":216.0, "partner":"7pdd" @@ -542489,6 +544566,10 @@ "sim":216.0, "partner":"7pdh" }, + { + "sim":216.0, + "partner":"7pd8" + }, { "sim":206.0, "partner":"5itz" @@ -542535,19 +544616,19 @@ }, { "sim":187.0, - "partner":"6d66" + "partner":"4hrn" }, { "sim":187.0, - "partner":"4hrn" + "partner":"2xzt" }, { "sim":187.0, - "partner":"6d67" + "partner":"6d66" }, { "sim":187.0, - "partner":"2xzt" + "partner":"6d67" }, { "sim":186.0, @@ -542567,11 +544648,11 @@ }, { "sim":159.0, - "partner":"6ndz" + "partner":"6ne2" }, { "sim":159.0, - "partner":"6ne2" + "partner":"6ndz" }, { "sim":158.0, @@ -542587,23 +544668,23 @@ }, { "sim":124.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":124.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":124.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":124.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":124.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":124.0, @@ -542611,11 +544692,11 @@ }, { "sim":124.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":124.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":124.0, @@ -542729,17 +544810,13 @@ "sim":113.0, "partner":"5vkq" }, - { - "sim":108.0, - "partner":"4cym" - }, { "sim":108.0, "partner":"4cz2" }, { "sim":108.0, - "partner":"5vhj" + "partner":"4cym" }, { "sim":108.0, @@ -542771,15 +544848,15 @@ }, { "sim":108.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":108.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":108.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":108.0, @@ -542789,6 +544866,10 @@ "sim":108.0, "partner":"7vxw" }, + { + "sim":108.0, + "partner":"1uoh" + }, { "sim":108.0, "partner":"7vy4" @@ -542799,11 +544880,11 @@ }, { "sim":108.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":108.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":108.0, @@ -542815,15 +544896,15 @@ }, { "sim":108.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":108.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":108.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":108.0, @@ -542863,15 +544944,15 @@ }, { "sim":98.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":98.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":98.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":98.0, @@ -543023,11 +545104,11 @@ }, { "sim":91.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":91.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":91.0, @@ -543093,10 +545174,6 @@ "sim":86.0, "partner":"6wj5" }, - { - "sim":86.0, - "partner":"6v9x" - }, { "sim":86.0, "partner":"6v9y" @@ -543109,6 +545186,10 @@ "sim":86.0, "partner":"6v9w" }, + { + "sim":86.0, + "partner":"6v9x" + }, { "sim":86.0, "partner":"7or0" @@ -543203,19 +545284,19 @@ }, { "sim":81.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":81.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":81.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":81.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":81.0, @@ -543233,14 +545314,6 @@ "sim":81.0, "partner":"5ybe" }, - { - "sim":81.0, - "partner":"6m11" - }, - { - "sim":81.0, - "partner":"6m12" - }, { "sim":81.0, "partner":"6m13" @@ -543265,6 +545338,14 @@ "sim":81.0, "partner":"4o1p" }, + { + "sim":81.0, + "partner":"6m11" + }, + { + "sim":81.0, + "partner":"6m12" + }, { "sim":80.0, "partner":"1myo" @@ -543317,10 +545398,6 @@ "sim":76.0, "partner":"5wo6" }, - { - "sim":76.0, - "partner":"5iwr" - }, { "sim":76.0, "partner":"5iwt" @@ -543373,6 +545450,10 @@ "sim":76.0, "partner":"5iwp" }, + { + "sim":76.0, + "partner":"5iwr" + }, { "sim":76.0, "partner":"5wo7" @@ -543383,19 +545464,19 @@ }, { "sim":75.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":75.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":73.0, - "partner":"5z2n" + "partner":"1d9s" }, { "sim":73.0, - "partner":"1d9s" + "partner":"5z2n" }, { "sim":73.0, @@ -543415,15 +545496,15 @@ }, { "sim":72.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":72.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":72.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":72.0, @@ -543453,10 +545534,6 @@ "sim":72.0, "partner":"3t9k" }, - { - "sim":72.0, - "partner":"6o1p" - }, { "sim":72.0, "partner":"6b5v" @@ -543495,7 +545572,7 @@ }, { "sim":72.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":72.0, @@ -543529,6 +545606,10 @@ "sim":72.0, "partner":"7t6l" }, + { + "sim":72.0, + "partner":"7t6m" + }, { "sim":70.0, "partner":"4uuc" @@ -543545,10 +545626,6 @@ "sim":68.0, "partner":"1oy3" }, - { - "sim":68.0, - "partner":"7k4a" - }, { "sim":68.0, "partner":"7k4b" @@ -543571,7 +545648,7 @@ }, { "sim":68.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":68.0, @@ -543587,11 +545664,11 @@ }, { "sim":68.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":68.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":68.0, @@ -543609,6 +545686,10 @@ "sim":68.0, "partner":"6bo8" }, + { + "sim":68.0, + "partner":"6bo9" + }, { "sim":66.0, "partner":"8pef" @@ -544090,116 +546171,116 @@ ], "subtitle":"Crystal structure of p63 dna binding domain in complex with inhibitory darpin g4", "tags":[ - "darpin", - "p63 dbd", + "inhibitor", "transcription", - "inhibitor" + "p63 dbd", + "darpin" ], "keywords":[ - "domain", - "evidence", - "genetic", - "providing", - "thus", - "roles", - "regulated", - "designed", + "isoform", + "individual", "allow", - "determine", - "reactivated", + "organic", + "structural", + "repeat", "show", - "versatile", - "bind", - "conformation", + "incompetent", + "well", + "regulated", + "roles", + "within", + "protein", + "pockets", "members", + "tissue", + "binding", "identifying", - "repeat", - "inhibitors", - "inhibiting", - "primary", - "modulation", - "\u03b4np63\u03b1", - "proteins", + "domains", + "transcription", + "special", + "deep", + "conformation", + "p53", + "furthermore", + "overall", + "selected", "dna", - "cell", - "specifically", + "thus", "family", - "isoform", + "factors", + "folded", + "bind", + "transcriptional", + "proteins", + "sites", + "evidence", + "characterization", + "several", + "factor", + "ankyrin", "small", - "used", - "tap63\u03b1", - "difficult", - "targeted", - "easily", + "contain", + "tight", + "studying", + "investigate", + "lack", + "inhibiting", + "p73", + "intracellular", "binders", - "promoter", + "used", "suggests", + "research", + "reactivated", + "domain", + "addition", + "tool", + "stabilizes", + "also", + "easily", + "p63", + "cell", + "oligomerization", + "constitute", + "sterile", "detect", + "primary", "ability", - "folded", - "furthermore", - "stabilizes", + "selectively", + "plasticity", + "versatile", "competes", + "developed", + "inhibition", + "describe", + "determine", + "darpins", + "culture", + "designed", + "dependent", + "one", + "targeted", + "specificities", + "providing", + "loop", "feedback", - "individual", - "pockets", + "tap63\u03b1", + "\u03b4np63\u03b1", + "specifically", + "powerful", + "modulation", + "inhibitors", "function", - "research", + "procedures", "molecules", - "investigate", - "special", - "powerful", - "tissue", - "factors", - "oligomerization", - "incompetent", - "darpins", - "specificities", "transcriptionally", - "p63", + "high", "activity", - "p73", - "organic", - "several", - "characterization", - "selectively", "negative", - "describe", - "high", - "sterile", - "structural", - "selected", - "sites", - "factor", - "procedures", - "overall", - "one", - "lack", - "also", - "p53", - "tight", - "intracellular", - "well", - "ankyrin", - "affinities", - "culture", - "transcriptional", - "studying", - "constitute", - "addition", - "domains", - "inhibition", - "transcription", - "protein", - "dependent", - "within", - "deep", - "binding", - "developed", - "loop", - "contain", - "tool", - "plasticity" + "genetic", + "difficult", + "promoter", + "affinities" ], "release_date":"2022-06-29", "publication":"\"Designed Ankyrin Repeat Proteins as a tool box for analyzing p63\", Cell Death Differ., 29, 2445-2458", @@ -544296,11 +546377,11 @@ }, { "sim":262.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":262.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":261.0, @@ -544312,7 +546393,7 @@ }, { "sim":261.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":261.0, @@ -544320,15 +546401,15 @@ }, { "sim":261.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":261.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":261.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":261.0, @@ -544336,15 +546417,15 @@ }, { "sim":261.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":261.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":261.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":261.0, @@ -544352,23 +546433,23 @@ }, { "sim":261.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":261.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":261.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":261.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":261.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":258.0, @@ -544452,7 +546533,7 @@ }, { "sim":246.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":246.0, @@ -544460,7 +546541,7 @@ }, { "sim":246.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":243.0, @@ -544492,11 +546573,11 @@ }, { "sim":239.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":239.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":239.0, @@ -544516,11 +546597,11 @@ }, { "sim":211.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":211.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":211.0, @@ -544546,6 +546627,10 @@ "sim":198.0, "partner":"8ak1" }, + { + "sim":194.0, + "partner":"9glq" + }, { "sim":193.0, "partner":"2jab" @@ -544646,11 +546731,11 @@ }, { "sim":272.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":272.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":272.0, @@ -544742,7 +546827,7 @@ }, { "sim":261.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":261.0, @@ -544750,11 +546835,11 @@ }, { "sim":261.0, - "partner":"6mze" + "partner":"7z02" }, { "sim":261.0, - "partner":"7z02" + "partner":"7ac5" }, { "sim":261.0, @@ -544762,11 +546847,11 @@ }, { "sim":261.0, - "partner":"7ac5" + "partner":"4lnu" }, { "sim":261.0, - "partner":"4lnu" + "partner":"6zwb" }, { "sim":261.0, @@ -544782,15 +546867,15 @@ }, { "sim":261.0, - "partner":"6zwb" + "partner":"6zwc" }, { "sim":261.0, - "partner":"6zwc" + "partner":"3nog" }, { "sim":261.0, - "partner":"3nog" + "partner":"7z01" }, { "sim":260.0, @@ -544840,17 +546925,13 @@ "sim":257.0, "partner":"6s8k" }, - { - "sim":257.0, - "partner":"5oyj" - }, { "sim":257.0, "partner":"2bkk" }, { - "sim":256.0, - "partner":"7pjf" + "sim":257.0, + "partner":"5oyj" }, { "sim":256.0, @@ -544858,27 +546939,23 @@ }, { "sim":256.0, - "partner":"5eno" - }, - { - "sim":256.0, - "partner":"6zob" + "partner":"7pjf" }, { "sim":256.0, - "partner":"6zo5" + "partner":"4dx6" }, { "sim":256.0, - "partner":"4dx6" + "partner":"6sgs" }, { "sim":256.0, - "partner":"6q4n" + "partner":"6zoc" }, { "sim":256.0, - "partner":"6zoc" + "partner":"6zo6" }, { "sim":256.0, @@ -544886,11 +546963,11 @@ }, { "sim":256.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":256.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":256.0, @@ -544898,11 +546975,11 @@ }, { "sim":256.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":256.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":256.0, @@ -544910,11 +546987,11 @@ }, { "sim":256.0, - "partner":"6zod" + "partner":"6zo7" }, { "sim":256.0, - "partner":"7b8r" + "partner":"6zoe" }, { "sim":256.0, @@ -544922,19 +546999,15 @@ }, { "sim":256.0, - "partner":"6zo7" - }, - { - "sim":256.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":256.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":256.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":256.0, @@ -544948,10 +547021,6 @@ "sim":256.0, "partner":"4u96" }, - { - "sim":256.0, - "partner":"7b8s" - }, { "sim":256.0, "partner":"6zo8" @@ -544962,15 +547031,11 @@ }, { "sim":256.0, - "partner":"5enr" - }, - { - "sim":256.0, - "partner":"4u8v" + "partner":"6sgu" }, { "sim":256.0, - "partner":"6sgu" + "partner":"5enr" }, { "sim":256.0, @@ -544978,11 +547043,11 @@ }, { "sim":256.0, - "partner":"2y1l" + "partner":"4u8v" }, { "sim":256.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":256.0, @@ -544994,11 +547059,11 @@ }, { "sim":256.0, - "partner":"7b8t" + "partner":"2y1l" }, { "sim":256.0, - "partner":"5ens" + "partner":"5nc5" }, { "sim":256.0, @@ -545006,11 +547071,11 @@ }, { "sim":256.0, - "partner":"5en5" + "partner":"5ens" }, { "sim":256.0, - "partner":"4u8y" + "partner":"5en5" }, { "sim":256.0, @@ -545020,6 +547085,14 @@ "sim":256.0, "partner":"6zoh" }, + { + "sim":256.0, + "partner":"4u8y" + }, + { + "sim":256.0, + "partner":"6sgr" + }, { "sim":256.0, "partner":"4c48" @@ -545034,12 +547107,24 @@ }, { "sim":256.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":256.0, "partner":"4dx5" }, + { + "sim":256.0, + "partner":"5eno" + }, + { + "sim":256.0, + "partner":"6zo5" + }, + { + "sim":256.0, + "partner":"6q4n" + }, { "sim":255.0, "partner":"6h46" @@ -545178,11 +547263,11 @@ }, { "sim":240.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":240.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":238.0, @@ -545226,20 +547311,16 @@ }, { "sim":220.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":220.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":218.0, "partner":"6moi" }, - { - "sim":210.0, - "partner":"7pd8" - }, { "sim":210.0, "partner":"7pdd" @@ -545252,6 +547333,10 @@ "sim":210.0, "partner":"7pdh" }, + { + "sim":210.0, + "partner":"7pd8" + }, { "sim":208.0, "partner":"5itz" @@ -545460,10 +547545,6 @@ "sim":110.0, "partner":"2l6b" }, - { - "sim":109.0, - "partner":"5vhj" - }, { "sim":109.0, "partner":"5vhh" @@ -545494,16 +547575,20 @@ }, { "sim":109.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":109.0, - "partner":"1uoh" + "partner":"5vhp" }, { "sim":109.0, "partner":"7vo6" }, + { + "sim":109.0, + "partner":"1uoh" + }, { "sim":109.0, "partner":"5vhi" @@ -545522,15 +547607,15 @@ }, { "sim":108.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":108.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":108.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":106.0, @@ -545586,11 +547671,11 @@ }, { "sim":99.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":99.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":98.0, @@ -545642,11 +547727,11 @@ }, { "sim":95.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":95.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":95.0, @@ -545878,19 +547963,19 @@ }, { "sim":81.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":81.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":81.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":81.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":81.0, @@ -545924,10 +548009,6 @@ "sim":79.0, "partner":"5wo6" }, - { - "sim":79.0, - "partner":"5iwr" - }, { "sim":79.0, "partner":"5iwt" @@ -545982,15 +548063,11 @@ }, { "sim":79.0, - "partner":"5wo7" - }, - { - "sim":79.0, - "partner":"6m11" + "partner":"5iwr" }, { "sim":79.0, - "partner":"6m12" + "partner":"5wo7" }, { "sim":79.0, @@ -546018,7 +548095,11 @@ }, { "sim":79.0, - "partner":"6v9x" + "partner":"6m11" + }, + { + "sim":79.0, + "partner":"6m12" }, { "sim":79.0, @@ -546032,6 +548113,10 @@ "sim":79.0, "partner":"6v9w" }, + { + "sim":79.0, + "partner":"6v9x" + }, { "sim":79.0, "partner":"7or0" @@ -546100,10 +548185,6 @@ "sim":76.0, "partner":"6wj5" }, - { - "sim":75.0, - "partner":"6o1p" - }, { "sim":75.0, "partner":"6b5v" @@ -546142,7 +548223,7 @@ }, { "sim":75.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":75.0, @@ -546176,6 +548257,10 @@ "sim":75.0, "partner":"7t6l" }, + { + "sim":75.0, + "partner":"7t6m" + }, { "sim":74.0, "partner":"1ymp" @@ -546222,11 +548307,11 @@ }, { "sim":71.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":71.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":70.0, @@ -546248,10 +548333,6 @@ "sim":70.0, "partner":"4ot9" }, - { - "sim":70.0, - "partner":"7k4a" - }, { "sim":70.0, "partner":"7k4b" @@ -546274,7 +548355,7 @@ }, { "sim":70.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":70.0, @@ -546290,11 +548371,11 @@ }, { "sim":70.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":70.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":70.0, @@ -546312,21 +548393,25 @@ "sim":70.0, "partner":"6bo8" }, + { + "sim":70.0, + "partner":"6bo9" + }, { "sim":69.0, "partner":"8pef" }, { "sim":68.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":68.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":68.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":68.0, @@ -546853,11 +548938,11 @@ ], "subtitle":"Solution nmr structure of the hth_8cm consensus miniprotein in 30% tfe at 278k", "tags":[ - "tfe", "graph theory", "de novo protein", - "consensus", - "miniprotein" + "tfe", + "miniprotein", + "consensus" ], "keywords":[ "description", @@ -546973,13 +549058,13 @@ "subtitle":"Crystal structure of pizza6-tnh-tsh with silicotungstic acid (sta) polyoxometalate", "tags":[ "silicotungstic acid", - "beta propeller", - "synthetic", + "sta", "co-crystal", - "unknown function", - "designer", "polyoxometalate", - "sta" + "synthetic", + "unknown function", + "beta propeller", + "designer" ], "keywords":[ "description", @@ -547028,23 +549113,23 @@ }, { "sim":494.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":494.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":494.0, - "partner":"7zpz" + "partner":"6qse" }, { "sim":494.0, - "partner":"7ov7" + "partner":"7zph" }, { "sim":494.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":494.0, @@ -547052,23 +549137,23 @@ }, { "sim":494.0, - "partner":"7zph" + "partner":"6qsg" }, { "sim":494.0, - "partner":"6reh" + "partner":"6qsh" }, { "sim":494.0, - "partner":"6qsg" + "partner":"6qsd" }, { "sim":494.0, - "partner":"6qsd" + "partner":"7zpz" }, { "sim":494.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":493.0, @@ -547084,15 +549169,15 @@ }, { "sim":488.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":488.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":488.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":488.0, @@ -547116,11 +549201,11 @@ }, { "sim":464.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":464.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":464.0, @@ -547128,7 +549213,7 @@ }, { "sim":464.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":447.0, @@ -547136,11 +549221,11 @@ }, { "sim":165.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":165.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":164.0, @@ -547158,11 +549243,11 @@ "seq_thr_sim_natural":[ { "sim":333.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":333.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":94.0, @@ -547246,15 +549331,15 @@ }, { "sim":59.0, - "partner":"8dvn" + "partner":"8dvl" }, { "sim":59.0, - "partner":"8dvl" + "partner":"8dvm" }, { "sim":59.0, - "partner":"8dvm" + "partner":"8dvn" }, { "sim":57.0, @@ -547372,7 +549457,7 @@ }, "seq_max_sim_natural":{ "sim":333.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9844999909, @@ -547446,126 +549531,126 @@ ], "subtitle":"Crystal structure of designed photoenzyme ent1.0", "tags":[ - "genetic code expansion", - "[2+2]-cyclase", "engineered enzyme", - "designed photoenzyme", - "biosynthetic protein" + "biosynthetic protein", + "[2+2]-cyclase", + "genetic code expansion", + "designed photoenzyme" ], "keywords":[ - "work", - "opens", - "evolution", - "genetic", + "performs", + "turnovers", + "allow", + "organic", + "proved", + "development", + "establishes", + "excess", "multiple", - "developing", - "modes", - "photocatalysts", - "catalysts", + "families", + "13", + "side", "acid", - "intramolecular", - "including", - "temperatures", - "cycloadditions", - "allow", + "framework", + "elements", + "new", + "developing", + "ambient", + "study", + "protein", + "installation", + "novo", + "subsequent", + "promise", "crystal", - "photoenzyme", - "holds", - "versatile", - "300", - "structure", - "bimolecular", + "expansion", + "chains", + "temperatures", + "methodology", + "encoded", + "introduction", "achieve", - "catalysis", - "photosensitizer", - "develop", + "complex", + "chemistry", + "reactivity", + "program", + "shows", + "photocatalysis", + "modes", + "accessible", + "enantiomeric", "wealth", - "expansion", - "allows", + "ref", + "functions", "proteins", + "develop", + "sites", + "end", + "holds", "triplet", - "program", - "installation", - "de", - "elements", - "efficient", - "reactivity", + "intramolecular", + "300", + "scaffold", "enzyme", - "effectively", + "components", + "found", + "exploit", + "evolution", + "including", + "operate", + "catalysts", + "aerobic", + "challenging", + "energy", + "photosensitizer", + "expanded", + "work", + "active", + "cycloadditions", + "functional", + "platform", + "synthesis", + "selective", "beyond", - "nature", + "code", + "amino", + "mode", + "biocatalysis", + "conditions", + "allows", "ability", - "genetically", - "introduction", - "performs", - "enantiomeric", + "contrast", + "photoenzyme", + "selectively", + "versatile", + "effectively", + "present", + "implementation", + "catalysis", "99", "particular", - "proved", - "operate", - "synergy", - "shows", - "platform", - "framework", "generation", - "transformations", - "functional", - "amino", - "subsequent", - "conditions", - "components", - "families", - "ambient", - "noncanonical", + "efficient", + "photocatalysts", + "afforded", "enantioselective", - "challenging", - "would", - "code", - "mode", - "biocatalysis", - "active", - "functions", - "synthesis", - "transfer", - "organic", - "ref", + "opens", + "bimolecular", + "de", + "synergy", + "structure", "converts", - "promise", - "exploit", - "present", - "selectively", - "encoded", - "energy", - "promote", - "13", - "sites", - "chains", - "chemistry", - "accessible", "operates", - "study", - "novo", - "contrast", - "afforded", + "noncanonical", "means", - "establishes", - "implementation", - "found", - "turnovers", - "scaffold", - "selective", - "protein", - "complex", - "photocatalysis", - "development", - "end", + "nature", "ent", - "methodology", - "excess", - "side", - "expanded", - "aerobic", - "new" + "would", + "genetically", + "promote", + "transformations", + "genetic", + "transfer" ], "release_date":"2022-09-28", "publication":"\"A designed photoenzyme for enantioselective [2+2] cycloadditions\", Nature, 611, 709-714", @@ -547883,126 +549968,126 @@ ], "subtitle":"Crystal structure of evolved photoenzyme ent1.3", "tags":[ - "genetic code expansion", - "[2+2]-cyclase", "engineered enzyme", - "designed photoenzyme", - "biosynthetic protein" + "biosynthetic protein", + "[2+2]-cyclase", + "genetic code expansion", + "designed photoenzyme" ], "keywords":[ - "work", - "opens", - "evolution", - "genetic", + "performs", + "turnovers", + "allow", + "organic", + "proved", + "development", + "establishes", + "excess", "multiple", - "developing", - "modes", - "photocatalysts", - "catalysts", + "families", + "13", + "side", "acid", - "intramolecular", - "including", - "temperatures", - "cycloadditions", - "allow", + "framework", + "elements", + "new", + "developing", + "ambient", + "study", + "protein", + "installation", + "novo", + "subsequent", + "promise", "crystal", - "photoenzyme", - "holds", - "versatile", - "300", - "structure", - "bimolecular", + "expansion", + "chains", + "temperatures", + "methodology", + "encoded", + "introduction", "achieve", - "catalysis", - "photosensitizer", - "develop", + "complex", + "chemistry", + "reactivity", + "program", + "shows", + "photocatalysis", + "modes", + "accessible", + "enantiomeric", "wealth", - "expansion", - "allows", + "ref", + "functions", "proteins", + "develop", + "sites", + "end", + "holds", "triplet", - "program", - "installation", - "de", - "elements", - "efficient", - "reactivity", + "intramolecular", + "300", + "scaffold", "enzyme", - "effectively", + "components", + "found", + "exploit", + "evolution", + "including", + "operate", + "catalysts", + "aerobic", + "challenging", + "energy", + "photosensitizer", + "expanded", + "work", + "active", + "cycloadditions", + "functional", + "platform", + "synthesis", + "selective", "beyond", - "nature", + "code", + "amino", + "mode", + "biocatalysis", + "conditions", + "allows", "ability", - "genetically", - "introduction", - "performs", - "enantiomeric", + "contrast", + "photoenzyme", + "selectively", + "versatile", + "effectively", + "present", + "implementation", + "catalysis", "99", "particular", - "proved", - "operate", - "synergy", - "shows", - "platform", - "framework", "generation", - "transformations", - "functional", - "amino", - "subsequent", - "conditions", - "components", - "families", - "ambient", - "noncanonical", + "efficient", + "photocatalysts", + "afforded", "enantioselective", - "challenging", - "would", - "code", - "mode", - "biocatalysis", - "active", - "functions", - "synthesis", - "transfer", - "organic", - "ref", + "opens", + "bimolecular", + "de", + "synergy", + "structure", "converts", - "promise", - "exploit", - "present", - "selectively", - "encoded", - "energy", - "promote", - "13", - "sites", - "chains", - "chemistry", - "accessible", "operates", - "study", - "novo", - "contrast", - "afforded", + "noncanonical", "means", - "establishes", - "implementation", - "found", - "turnovers", - "scaffold", - "selective", - "protein", - "complex", - "photocatalysis", - "development", - "end", + "nature", "ent", - "methodology", - "excess", - "side", - "expanded", - "aerobic", - "new" + "would", + "genetically", + "promote", + "transformations", + "genetic", + "transfer" ], "release_date":"2022-09-28", "publication":"\"A designed photoenzyme for enantioselective [2+2] cycloadditions\", Nature, 611, 709-714", @@ -548244,126 +550329,126 @@ ], "subtitle":"Crystal structure of evolved photoenzyme ent1.3 (truncated) with bound product", "tags":[ - "genetic code expansion", - "[2+2]-cyclase", "engineered enzyme", - "designed photoenzyme", - "biosynthetic protein" + "biosynthetic protein", + "[2+2]-cyclase", + "genetic code expansion", + "designed photoenzyme" ], "keywords":[ - "work", - "opens", - "evolution", - "genetic", + "performs", + "turnovers", + "allow", + "organic", + "proved", + "development", + "establishes", + "excess", "multiple", - "developing", - "modes", - "photocatalysts", - "catalysts", + "families", + "13", + "side", "acid", - "intramolecular", - "including", - "temperatures", - "cycloadditions", - "allow", + "framework", + "elements", + "new", + "developing", + "ambient", + "study", + "protein", + "installation", + "novo", + "subsequent", + "promise", "crystal", - "photoenzyme", - "holds", - "versatile", - "300", - "structure", - "bimolecular", + "expansion", + "chains", + "temperatures", + "methodology", + "encoded", + "introduction", "achieve", - "catalysis", - "photosensitizer", - "develop", + "complex", + "chemistry", + "reactivity", + "program", + "shows", + "photocatalysis", + "modes", + "accessible", + "enantiomeric", "wealth", - "expansion", - "allows", + "ref", + "functions", "proteins", + "develop", + "sites", + "end", + "holds", "triplet", - "program", - "installation", - "de", - "elements", - "efficient", - "reactivity", + "intramolecular", + "300", + "scaffold", "enzyme", - "effectively", + "components", + "found", + "exploit", + "evolution", + "including", + "operate", + "catalysts", + "aerobic", + "challenging", + "energy", + "photosensitizer", + "expanded", + "work", + "active", + "cycloadditions", + "functional", + "platform", + "synthesis", + "selective", "beyond", - "nature", + "code", + "amino", + "mode", + "biocatalysis", + "conditions", + "allows", "ability", - "genetically", - "introduction", - "performs", - "enantiomeric", + "contrast", + "photoenzyme", + "selectively", + "versatile", + "effectively", + "present", + "implementation", + "catalysis", "99", "particular", - "proved", - "operate", - "synergy", - "shows", - "platform", - "framework", "generation", - "transformations", - "functional", - "amino", - "subsequent", - "conditions", - "components", - "families", - "ambient", - "noncanonical", + "efficient", + "photocatalysts", + "afforded", "enantioselective", - "challenging", - "would", - "code", - "mode", - "biocatalysis", - "active", - "functions", - "synthesis", - "transfer", - "organic", - "ref", + "opens", + "bimolecular", + "de", + "synergy", + "structure", "converts", - "promise", - "exploit", - "present", - "selectively", - "encoded", - "energy", - "promote", - "13", - "sites", - "chains", - "chemistry", - "accessible", "operates", - "study", - "novo", - "contrast", - "afforded", + "noncanonical", "means", - "establishes", - "implementation", - "found", - "turnovers", - "scaffold", - "selective", - "protein", - "complex", - "photocatalysis", - "development", - "end", + "nature", "ent", - "methodology", - "excess", - "side", - "expanded", - "aerobic", - "new" + "would", + "genetically", + "promote", + "transformations", + "genetic", + "transfer" ], "release_date":"2022-09-28", "publication":"\"A designed photoenzyme for enantioselective [2+2] cycloadditions\", Nature, 611, 709-714", @@ -548546,19 +550631,19 @@ }, { "sim":58.0, - "partner":"3nha" + "partner":"3nh6" }, { "sim":58.0, - "partner":"3nhb" + "partner":"3nh9" }, { "sim":58.0, - "partner":"3nh6" + "partner":"3nha" }, { "sim":58.0, - "partner":"3nh9" + "partner":"3nhb" }, { "sim":58.0, @@ -548586,27 +550671,15 @@ }, { "sim":57.0, - "partner":"3jq9" - }, - { - "sim":57.0, - "partner":"4cm3" - }, - { - "sim":57.0, - "partner":"4cmb" - }, - { - "sim":57.0, - "partner":"5jcj" + "partner":"2yhi" }, { "sim":57.0, - "partner":"6gdp" + "partner":"3bmc" }, { "sim":57.0, - "partner":"6rx0" + "partner":"3jqa" }, { "sim":57.0, @@ -548618,35 +550691,31 @@ }, { "sim":57.0, - "partner":"6gcl" - }, - { - "sim":57.0, - "partner":"2yhi" + "partner":"4cm4" }, { "sim":57.0, - "partner":"3bmc" + "partner":"4cmc" }, { "sim":57.0, - "partner":"4cm4" + "partner":"5jcj" }, { "sim":57.0, - "partner":"4cmc" + "partner":"5k6a" }, { "sim":57.0, - "partner":"5k6a" + "partner":"6gcp" }, { "sim":57.0, - "partner":"3jqa" + "partner":"6gcq" }, { "sim":57.0, - "partner":"6gcp" + "partner":"6gd0" }, { "sim":57.0, @@ -548666,31 +550735,31 @@ }, { "sim":57.0, - "partner":"6gcq" + "partner":"4clr" }, { "sim":57.0, - "partner":"6gd0" + "partner":"4cme" }, { "sim":57.0, - "partner":"4clr" + "partner":"3bmo" }, { "sim":57.0, - "partner":"4cme" + "partner":"4cm6" }, { "sim":57.0, - "partner":"3bmo" + "partner":"3jqc" }, { "sim":57.0, - "partner":"4cm6" + "partner":"6gex" }, { "sim":57.0, - "partner":"3jqc" + "partner":"6tbx" }, { "sim":57.0, @@ -548714,11 +550783,7 @@ }, { "sim":57.0, - "partner":"6gex" - }, - { - "sim":57.0, - "partner":"6tbx" + "partner":"6rx6" }, { "sim":57.0, @@ -548734,35 +550799,35 @@ }, { "sim":57.0, - "partner":"6rx6" + "partner":"6gey" }, { "sim":57.0, - "partner":"5jdi" + "partner":"6hnc" }, { "sim":57.0, - "partner":"3gn2" + "partner":"5jdi" }, { "sim":57.0, - "partner":"4cle" + "partner":"3gn2" }, { "sim":57.0, - "partner":"6gey" + "partner":"4cle" }, { "sim":57.0, - "partner":"6hnc" + "partner":"4clx" }, { "sim":57.0, - "partner":"4clx" + "partner":"4cm8" }, { "sim":57.0, - "partner":"4cm8" + "partner":"7opj" }, { "sim":57.0, @@ -548774,7 +550839,7 @@ }, { "sim":57.0, - "partner":"7opj" + "partner":"6gd4" }, { "sim":57.0, @@ -548788,10 +550853,6 @@ "sim":57.0, "partner":"5jcx" }, - { - "sim":57.0, - "partner":"6gd4" - }, { "sim":57.0, "partner":"4clh" @@ -548808,6 +550869,10 @@ "sim":57.0, "partner":"3jqf" }, + { + "sim":57.0, + "partner":"6hnr" + }, { "sim":57.0, "partner":"4cmj" @@ -548818,12 +550883,16 @@ }, { "sim":57.0, - "partner":"6hnr" + "partner":"6how" }, { "sim":57.0, "partner":"4cma" }, + { + "sim":57.0, + "partner":"6gdo" + }, { "sim":57.0, "partner":"2x9g" @@ -548842,7 +550911,7 @@ }, { "sim":57.0, - "partner":"6how" + "partner":"6rx0" }, { "sim":57.0, @@ -548850,31 +550919,51 @@ }, { "sim":57.0, - "partner":"6gdo" + "partner":"4cm3" }, { "sim":57.0, - "partner":"7a61" + "partner":"4cmb" }, { "sim":57.0, - "partner":"5uj3" + "partner":"6gdp" }, { "sim":57.0, - "partner":"5uj4" + "partner":"3jq9" + }, + { + "sim":57.0, + "partner":"6gcl" + }, + { + "sim":57.0, + "partner":"8rwq" }, { "sim":57.0, "partner":"6mnp" }, + { + "sim":57.0, + "partner":"8rwr" + }, + { + "sim":57.0, + "partner":"5uj3" + }, { "sim":57.0, "partner":"6d15" }, { "sim":57.0, - "partner":"5ul8" + "partner":"8rws" + }, + { + "sim":57.0, + "partner":"5uj4" }, { "sim":57.0, @@ -548888,6 +550977,10 @@ "sim":57.0, "partner":"6d17" }, + { + "sim":57.0, + "partner":"5ul8" + }, { "sim":57.0, "partner":"6d18" @@ -548940,10 +551033,6 @@ "sim":57.0, "partner":"6qwe" }, - { - "sim":57.0, - "partner":"8rwq" - }, { "sim":57.0, "partner":"6mey" @@ -548970,15 +551059,19 @@ }, { "sim":57.0, - "partner":"1l9x" + "partner":"7a61" }, { "sim":57.0, - "partner":"7v52" + "partner":"8rwo" }, { "sim":57.0, - "partner":"7v54" + "partner":"8rwp" + }, + { + "sim":57.0, + "partner":"1l9x" }, { "sim":57.0, @@ -548998,7 +551091,11 @@ }, { "sim":57.0, - "partner":"7rpw" + "partner":"7v52" + }, + { + "sim":57.0, + "partner":"7v54" }, { "sim":57.0, @@ -549016,6 +551113,10 @@ "sim":57.0, "partner":"7rpo" }, + { + "sim":57.0, + "partner":"7rpw" + }, { "sim":56.0, "partner":"5u0i" @@ -549060,10 +551161,6 @@ "sim":56.0, "partner":"7aic" }, - { - "sim":56.0, - "partner":"5akd" - }, { "sim":56.0, "partner":"5akb" @@ -549074,12 +551171,16 @@ }, { "sim":56.0, - "partner":"7f79" + "partner":"5akd" }, { "sim":56.0, "partner":"7f77" }, + { + "sim":56.0, + "partner":"7f79" + }, { "sim":55.0, "partner":"6zdx" @@ -549112,10 +551213,6 @@ "sim":55.0, "partner":"6jxn" }, - { - "sim":55.0, - "partner":"4be6" - }, { "sim":55.0, "partner":"4bei" @@ -549130,19 +551227,19 @@ }, { "sim":55.0, - "partner":"4lbd" + "partner":"4be6" }, { "sim":55.0, - "partner":"3lbd" + "partner":"4lbd" }, { "sim":55.0, - "partner":"2lbd" + "partner":"3lbd" }, { "sim":55.0, - "partner":"6hxo" + "partner":"2lbd" }, { "sim":55.0, @@ -549150,15 +551247,11 @@ }, { "sim":55.0, - "partner":"3cu0" - }, - { - "sim":55.0, - "partner":"1u1v" + "partner":"6hxo" }, { "sim":55.0, - "partner":"1u1w" + "partner":"3cu0" }, { "sim":55.0, @@ -549178,15 +551271,15 @@ }, { "sim":55.0, - "partner":"6mhp" + "partner":"1u1v" }, { "sim":55.0, - "partner":"5glm" + "partner":"1u1w" }, { "sim":55.0, - "partner":"5gln" + "partner":"6mhp" }, { "sim":55.0, @@ -549212,6 +551305,14 @@ "sim":55.0, "partner":"5gll" }, + { + "sim":55.0, + "partner":"5glm" + }, + { + "sim":55.0, + "partner":"5gln" + }, { "sim":55.0, "partner":"3wxy" @@ -549226,11 +551327,11 @@ }, { "sim":55.0, - "partner":"6e9b" + "partner":"6e57" }, { "sim":55.0, - "partner":"6e57" + "partner":"6e9b" }, { "sim":55.0, @@ -549246,35 +551347,35 @@ }, { "sim":55.0, - "partner":"3ahc" + "partner":"3ahf" }, { "sim":55.0, - "partner":"3ahd" + "partner":"3ahg" }, { "sim":55.0, - "partner":"3ahe" + "partner":"3ahh" }, { "sim":55.0, - "partner":"3ahf" + "partner":"3ahi" }, { "sim":55.0, - "partner":"3ahg" + "partner":"3ahj" }, { "sim":55.0, - "partner":"3ahh" + "partner":"3ahc" }, { "sim":55.0, - "partner":"3ahi" + "partner":"3ahd" }, { "sim":55.0, - "partner":"3ahj" + "partner":"3ahe" }, { "sim":55.0, @@ -549328,10 +551429,6 @@ "sim":54.0, "partner":"5owf" }, - { - "sim":54.0, - "partner":"4yvk" - }, { "sim":54.0, "partner":"4yqd" @@ -549356,6 +551453,10 @@ "sim":54.0, "partner":"4yvj" }, + { + "sim":54.0, + "partner":"4yvk" + }, { "sim":54.0, "partner":"4ke9" @@ -549484,10 +551585,6 @@ "sim":54.0, "partner":"7f6d" }, - { - "sim":54.0, - "partner":"7azd" - }, { "sim":54.0, "partner":"7az5" @@ -549518,11 +551615,11 @@ }, { "sim":54.0, - "partner":"5x06" + "partner":"7azg" }, { "sim":54.0, - "partner":"7azg" + "partner":"5x06" }, { "sim":54.0, @@ -549530,12 +551627,16 @@ }, { "sim":54.0, - "partner":"6wa9" + "partner":"7azd" }, { "sim":54.0, "partner":"6wa6" }, + { + "sim":54.0, + "partner":"6wa9" + }, { "sim":54.0, "partner":"2gej" @@ -549602,15 +551703,15 @@ }, { "sim":53.0, - "partner":"5wg9" + "partner":"5wap" }, { "sim":53.0, - "partner":"8dvo" + "partner":"6v56" }, { "sim":53.0, - "partner":"5wap" + "partner":"6whm" }, { "sim":53.0, @@ -549618,27 +551719,23 @@ }, { "sim":53.0, - "partner":"6v56" - }, - { - "sim":53.0, - "partner":"6whm" + "partner":"6v9e" }, { "sim":53.0, - "partner":"5w7u" + "partner":"6vbr" }, { "sim":53.0, - "partner":"6v9e" + "partner":"7mty" }, { "sim":53.0, - "partner":"7mty" + "partner":"8e21" }, { "sim":53.0, - "partner":"6vbr" + "partner":"5w7u" }, { "sim":53.0, @@ -549650,11 +551747,11 @@ }, { "sim":53.0, - "partner":"8e21" + "partner":"5wfw" }, { "sim":53.0, - "partner":"5wfw" + "partner":"8dqs" }, { "sim":53.0, @@ -549662,15 +551759,15 @@ }, { "sim":53.0, - "partner":"5dbs" + "partner":"7kbc" }, { "sim":53.0, - "partner":"7kbc" + "partner":"5dbs" }, { "sim":53.0, - "partner":"5w9g" + "partner":"6vjh" }, { "sim":53.0, @@ -549678,32 +551775,28 @@ }, { "sim":53.0, - "partner":"8dqs" + "partner":"8dpj" }, { "sim":53.0, - "partner":"5vqn" + "partner":"5w9g" }, { "sim":53.0, - "partner":"5wdw" + "partner":"5vqn" }, { "sim":53.0, - "partner":"5wfz" + "partner":"5wdw" }, { "sim":53.0, - "partner":"6vjh" + "partner":"5wfz" }, { "sim":53.0, "partner":"7n68" }, - { - "sim":53.0, - "partner":"8dpj" - }, { "sim":53.0, "partner":"5czn" @@ -549718,23 +551811,23 @@ }, { "sim":53.0, - "partner":"5vpt" + "partner":"6w7a" }, { "sim":53.0, - "partner":"6w7a" + "partner":"5vpt" }, { "sim":53.0, - "partner":"5w92" + "partner":"7n47" }, { "sim":53.0, - "partner":"5wa6" + "partner":"5w92" }, { "sim":53.0, - "partner":"7n47" + "partner":"5wa6" }, { "sim":53.0, @@ -549750,19 +551843,19 @@ }, { "sim":53.0, - "partner":"5vrj" + "partner":"6wj4" }, { "sim":53.0, - "partner":"6wj4" + "partner":"5vrj" }, { "sim":53.0, - "partner":"7mx0" + "partner":"6ws3" }, { "sim":53.0, - "partner":"6ws3" + "partner":"7mx0" }, { "sim":53.0, @@ -549786,27 +551879,27 @@ }, { "sim":53.0, - "partner":"2cdn" + "partner":"8dvo" }, { "sim":53.0, - "partner":"2iss" + "partner":"5wg9" }, { "sim":53.0, - "partner":"7drj" + "partner":"2cdn" }, { "sim":53.0, - "partner":"7drk" + "partner":"2iss" }, { "sim":53.0, - "partner":"4njh" + "partner":"7drj" }, { "sim":53.0, - "partner":"4nji" + "partner":"7drk" }, { "sim":53.0, @@ -549822,11 +551915,15 @@ }, { "sim":53.0, - "partner":"2xdu" + "partner":"4njh" }, { "sim":53.0, - "partner":"3la7" + "partner":"4nji" + }, + { + "sim":53.0, + "partner":"2xdu" }, { "sim":53.0, @@ -549836,6 +551933,10 @@ "sim":53.0, "partner":"3la3" }, + { + "sim":53.0, + "partner":"3la7" + }, { "sim":53.0, "partner":"4cnf" @@ -549894,59 +551995,59 @@ }, { "sim":53.0, - "partner":"5uto" + "partner":"7scl" }, { "sim":53.0, - "partner":"7scl" + "partner":"5uto" }, { "sim":53.0, - "partner":"7q2b" + "partner":"7q2f" }, { "sim":53.0, - "partner":"3ha3" + "partner":"7q2g" }, { "sim":53.0, - "partner":"7q2c" + "partner":"7q2h" }, { "sim":53.0, - "partner":"7q2d" + "partner":"3ha5" }, { "sim":53.0, - "partner":"7q2e" + "partner":"2fk7" }, { "sim":53.0, - "partner":"7q2f" + "partner":"2fk8" }, { "sim":53.0, - "partner":"7q2g" + "partner":"3ha7" }, { "sim":53.0, - "partner":"7q2h" + "partner":"7q2b" }, { "sim":53.0, - "partner":"3ha5" + "partner":"7q2c" }, { "sim":53.0, - "partner":"2fk7" + "partner":"3ha3" }, { "sim":53.0, - "partner":"2fk8" + "partner":"7q2d" }, { "sim":53.0, - "partner":"3ha7" + "partner":"7q2e" }, { "sim":53.0, @@ -550024,14 +552125,6 @@ "sim":53.0, "partner":"6l1g" }, - { - "sim":53.0, - "partner":"4h2w" - }, - { - "sim":53.0, - "partner":"3mey" - }, { "sim":53.0, "partner":"4h2x" @@ -550068,6 +552161,14 @@ "sim":53.0, "partner":"4h2v" }, + { + "sim":53.0, + "partner":"4h2w" + }, + { + "sim":53.0, + "partner":"3mey" + }, { "sim":53.0, "partner":"2whd" @@ -550116,29 +552217,13 @@ "sim":53.0, "partner":"6p5r" }, - { - "sim":53.0, - "partner":"3wkr" - }, { "sim":53.0, "partner":"3wks" }, { "sim":53.0, - "partner":"6p3v" - }, - { - "sim":53.0, - "partner":"6vur" - }, - { - "sim":53.0, - "partner":"6vus" - }, - { - "sim":53.0, - "partner":"6vut" + "partner":"3wkr" }, { "sim":53.0, @@ -550162,19 +552247,19 @@ }, { "sim":53.0, - "partner":"5tvj" + "partner":"6vuz" }, { "sim":53.0, - "partner":"6b3t" + "partner":"6vv0" }, { "sim":53.0, - "partner":"6vuz" + "partner":"5tvj" }, { "sim":53.0, - "partner":"6vv0" + "partner":"6b3t" }, { "sim":53.0, @@ -550194,15 +552279,15 @@ }, { "sim":53.0, - "partner":"5ec4" + "partner":"8d23" }, { "sim":53.0, - "partner":"8d23" + "partner":"8d1r" }, { "sim":53.0, - "partner":"8d1r" + "partner":"5ec4" }, { "sim":53.0, @@ -550232,6 +552317,22 @@ "sim":53.0, "partner":"6p3u" }, + { + "sim":53.0, + "partner":"6p3v" + }, + { + "sim":53.0, + "partner":"6vur" + }, + { + "sim":53.0, + "partner":"6vus" + }, + { + "sim":53.0, + "partner":"6vut" + }, { "sim":53.0, "partner":"7v4y" @@ -550272,14 +552373,6 @@ "sim":53.0, "partner":"3tkt" }, - { - "sim":53.0, - "partner":"6mlh" - }, - { - "sim":53.0, - "partner":"6mlw" - }, { "sim":53.0, "partner":"6nn1" @@ -550304,6 +552397,14 @@ "sim":53.0, "partner":"6mlf" }, + { + "sim":53.0, + "partner":"6mlh" + }, + { + "sim":53.0, + "partner":"6mlw" + }, { "sim":53.0, "partner":"3v6a" @@ -550418,15 +552519,15 @@ }, { "sim":52.0, - "partner":"2ese" + "partner":"2jne" }, { "sim":52.0, - "partner":"2jne" + "partner":"2es6" }, { "sim":52.0, - "partner":"2es6" + "partner":"2ese" }, { "sim":52.0, @@ -550468,10 +552569,6 @@ "sim":52.0, "partner":"4e7p" }, - { - "sim":52.0, - "partner":"3sw1" - }, { "sim":52.0, "partner":"5j3w" @@ -550488,6 +552585,10 @@ "sim":52.0, "partner":"5j4e" }, + { + "sim":52.0, + "partner":"3sw1" + }, { "sim":52.0, "partner":"7f0y" @@ -550520,18 +552621,6 @@ "sim":52.0, "partner":"4nsq" }, - { - "sim":52.0, - "partner":"6vll" - }, - { - "sim":52.0, - "partner":"6v53" - }, - { - "sim":52.0, - "partner":"6wij" - }, { "sim":52.0, "partner":"7kop" @@ -550548,6 +552637,10 @@ "sim":52.0, "partner":"6v6x" }, + { + "sim":52.0, + "partner":"8dtw" + }, { "sim":52.0, "partner":"7kny" @@ -550558,7 +552651,7 @@ }, { "sim":52.0, - "partner":"8dtw" + "partner":"8e1q" }, { "sim":52.0, @@ -550566,7 +552659,7 @@ }, { "sim":52.0, - "partner":"8e1q" + "partner":"6vl3" }, { "sim":52.0, @@ -550574,23 +552667,19 @@ }, { "sim":52.0, - "partner":"6vl3" + "partner":"8e4s" }, { "sim":52.0, "partner":"7n8f" }, - { - "sim":52.0, - "partner":"5vp8" - }, { "sim":52.0, "partner":"7k87" }, { "sim":52.0, - "partner":"8e4s" + "partner":"5vp8" }, { "sim":52.0, @@ -550598,11 +552687,11 @@ }, { "sim":52.0, - "partner":"7knr" + "partner":"6viv" }, { "sim":52.0, - "partner":"6viv" + "partner":"7knr" }, { "sim":52.0, @@ -550616,10 +552705,22 @@ "sim":52.0, "partner":"7lw6" }, + { + "sim":52.0, + "partner":"6vll" + }, { "sim":52.0, "partner":"7n55" }, + { + "sim":52.0, + "partner":"6v53" + }, + { + "sim":52.0, + "partner":"6wij" + }, { "sim":52.0, "partner":"3vco" @@ -550634,15 +552735,15 @@ }, { "sim":52.0, - "partner":"3oci" + "partner":"1y7o" }, { "sim":52.0, - "partner":"1y7o" + "partner":"3oc3" }, { "sim":52.0, - "partner":"3oc3" + "partner":"3oci" }, { "sim":52.0, @@ -550658,19 +552759,19 @@ }, { "sim":52.0, - "partner":"5n7o" + "partner":"6hry" }, { "sim":52.0, - "partner":"6hry" + "partner":"5n7o" }, { "sim":52.0, - "partner":"5n1c" + "partner":"6hrz" }, { "sim":52.0, - "partner":"6hrz" + "partner":"5n1c" }, { "sim":52.0, @@ -550722,15 +552823,15 @@ }, { "sim":52.0, - "partner":"4bmx" + "partner":"4bmz" }, { "sim":52.0, - "partner":"4bmy" + "partner":"4bmx" }, { "sim":52.0, - "partner":"4bmz" + "partner":"4bmy" }, { "sim":52.0, @@ -550744,10 +552845,6 @@ "sim":52.0, "partner":"2zvv" }, - { - "sim":52.0, - "partner":"1zw3" - }, { "sim":52.0, "partner":"1zvz" @@ -550760,6 +552857,10 @@ "sim":52.0, "partner":"1zw2" }, + { + "sim":52.0, + "partner":"1zw3" + }, { "sim":52.0, "partner":"3p8k" @@ -550804,10 +552905,6 @@ "sim":52.0, "partner":"2znj" }, - { - "sim":52.0, - "partner":"7xif" - }, { "sim":52.0, "partner":"7xig" @@ -550820,6 +552917,10 @@ "sim":52.0, "partner":"7xii" }, + { + "sim":52.0, + "partner":"7xif" + }, { "sim":52.0, "partner":"3el6" @@ -550852,10 +552953,6 @@ "sim":52.0, "partner":"6f26" }, - { - "sim":52.0, - "partner":"3u3r" - }, { "sim":52.0, "partner":"6bnt" @@ -550874,11 +552971,11 @@ }, { "sim":52.0, - "partner":"5wri" + "partner":"3u3r" }, { "sim":52.0, - "partner":"3aio" + "partner":"5wri" }, { "sim":52.0, @@ -550896,6 +552993,10 @@ "sim":52.0, "partner":"3ain" }, + { + "sim":52.0, + "partner":"3aio" + }, { "sim":52.0, "partner":"3h7r" @@ -550906,11 +553007,11 @@ }, { "sim":52.0, - "partner":"6vwr" + "partner":"6vwq" }, { "sim":52.0, - "partner":"6vwq" + "partner":"6vwr" }, { "sim":52.0, @@ -550918,7 +553019,7 @@ }, { "sim":52.0, - "partner":"6pi5" + "partner":"6pi6" }, { "sim":52.0, @@ -550926,16 +553027,12 @@ }, { "sim":52.0, - "partner":"6pi6" + "partner":"6pi5" }, { "sim":52.0, "partner":"7utf" }, - { - "sim":52.0, - "partner":"4m1i" - }, { "sim":52.0, "partner":"4d8f" @@ -550950,28 +553047,12 @@ }, { "sim":52.0, - "partner":"3c1y" - }, - { - "sim":52.0, - "partner":"5zzx" - }, - { - "sim":52.0, - "partner":"6a0d" + "partner":"4m1i" }, { "sim":52.0, "partner":"3c1z" }, - { - "sim":52.0, - "partner":"5zzy" - }, - { - "sim":52.0, - "partner":"6a0v" - }, { "sim":52.0, "partner":"5zzz" @@ -551134,7 +553215,23 @@ }, { "sim":52.0, - "partner":"2o0h" + "partner":"3c1y" + }, + { + "sim":52.0, + "partner":"5zzx" + }, + { + "sim":52.0, + "partner":"6a0d" + }, + { + "sim":52.0, + "partner":"5zzy" + }, + { + "sim":52.0, + "partner":"6a0v" }, { "sim":52.0, @@ -551144,6 +553241,10 @@ "sim":52.0, "partner":"2o0k" }, + { + "sim":52.0, + "partner":"2o0h" + }, { "sim":52.0, "partner":"3fvm" @@ -551166,27 +553267,27 @@ }, { "sim":52.0, - "partner":"6kjh" + "partner":"6kjp" }, { "sim":52.0, - "partner":"6kjj" + "partner":"6kjq" }, { "sim":52.0, - "partner":"6kjp" + "partner":"6kjr" }, { "sim":52.0, - "partner":"6kjq" + "partner":"6kjt" }, { "sim":52.0, - "partner":"6kjr" + "partner":"6kjh" }, { "sim":52.0, - "partner":"6kjt" + "partner":"6kjj" }, { "sim":52.0, @@ -551204,10 +553305,6 @@ "sim":52.0, "partner":"5tuk" }, - { - "sim":52.0, - "partner":"4lre" - }, { "sim":52.0, "partner":"4lrf" @@ -551240,6 +553337,10 @@ "sim":52.0, "partner":"4lrd" }, + { + "sim":52.0, + "partner":"4lre" + }, { "sim":52.0, "partner":"4w4t" @@ -551250,15 +553351,15 @@ }, { "sim":52.0, - "partner":"6v99" + "partner":"6v96" }, { "sim":52.0, - "partner":"6v9a" + "partner":"6v99" }, { "sim":52.0, - "partner":"6v96" + "partner":"6v9a" }, { "sim":52.0, @@ -551282,11 +553383,11 @@ }, { "sim":52.0, - "partner":"6vy9" + "partner":"6vya" }, { "sim":52.0, - "partner":"6vya" + "partner":"6vy9" }, { "sim":52.0, @@ -551302,11 +553403,11 @@ }, { "sim":52.0, - "partner":"1nj5" + "partner":"6p4o" }, { "sim":52.0, - "partner":"6p4o" + "partner":"1nj5" }, { "sim":52.0, @@ -551322,23 +553423,23 @@ }, { "sim":52.0, - "partner":"2cj9" + "partner":"2cja" }, { "sim":52.0, - "partner":"5o3m" + "partner":"2cim" }, { "sim":52.0, - "partner":"2cja" + "partner":"2cjb" }, { "sim":52.0, - "partner":"2cim" + "partner":"5o3m" }, { "sim":52.0, - "partner":"2cjb" + "partner":"2cj9" }, { "sim":52.0, @@ -551366,27 +553467,27 @@ }, { "sim":52.0, - "partner":"5lj7" + "partner":"5lil" }, { "sim":52.0, - "partner":"5lil" + "partner":"5lj6" }, { "sim":52.0, - "partner":"5lj6" + "partner":"5lj7" }, { "sim":52.0, - "partner":"6tsh" + "partner":"6tsk" }, { "sim":52.0, - "partner":"6tte" + "partner":"6tsh" }, { "sim":52.0, - "partner":"6tsk" + "partner":"6tte" }, { "sim":52.0, @@ -551442,11 +553543,11 @@ }, { "sim":51.0, - "partner":"5cvo" + "partner":"6nyo" }, { "sim":51.0, - "partner":"6nyo" + "partner":"5cvo" }, { "sim":51.0, @@ -551500,10 +553601,6 @@ "sim":51.0, "partner":"4gx7" }, - { - "sim":51.0, - "partner":"6ebc" - }, { "sim":51.0, "partner":"6ebd" @@ -551516,6 +553613,10 @@ "sim":51.0, "partner":"6eb4" }, + { + "sim":51.0, + "partner":"6ebc" + }, { "sim":51.0, "partner":"4lfk" @@ -551540,10 +553641,6 @@ "sim":51.0, "partner":"6c0z" }, - { - "sim":51.0, - "partner":"2vbq" - }, { "sim":51.0, "partner":"1s3z" @@ -551558,15 +553655,15 @@ }, { "sim":51.0, - "partner":"4yr8" + "partner":"2vbq" }, { "sim":51.0, - "partner":"5x9k" + "partner":"4yr8" }, { "sim":51.0, - "partner":"5aoz" + "partner":"5x9k" }, { "sim":51.0, @@ -551576,6 +553673,10 @@ "sim":51.0, "partner":"3ph4" }, + { + "sim":51.0, + "partner":"5aoz" + }, { "sim":51.0, "partner":"3u30" @@ -551652,10 +553753,6 @@ "sim":51.0, "partner":"5e1l" }, - { - "sim":51.0, - "partner":"3th5" - }, { "sim":51.0, "partner":"4gzl" @@ -551666,7 +553763,7 @@ }, { "sim":51.0, - "partner":"1t57" + "partner":"3th5" }, { "sim":51.0, @@ -551676,6 +553773,10 @@ "sim":51.0, "partner":"6fhm" }, + { + "sim":51.0, + "partner":"1t57" + }, { "sim":51.0, "partner":"3vwv" @@ -551734,15 +553835,15 @@ }, { "sim":51.0, - "partner":"5cvd" + "partner":"5cve" }, { "sim":51.0, - "partner":"5cve" + "partner":"6kdq" }, { "sim":51.0, - "partner":"6kdq" + "partner":"5cvd" }, { "sim":51.0, @@ -551756,14 +553857,6 @@ "sim":51.0, "partner":"3rpu" }, - { - "sim":51.0, - "partner":"3ft5" - }, - { - "sim":51.0, - "partner":"2xdx" - }, { "sim":51.0, "partner":"3ft8" @@ -551832,6 +553925,14 @@ "sim":51.0, "partner":"2xhx" }, + { + "sim":51.0, + "partner":"3ft5" + }, + { + "sim":51.0, + "partner":"2xdx" + }, { "sim":51.0, "partner":"4bn0" @@ -551858,11 +553959,11 @@ }, { "sim":51.0, - "partner":"5h5a" + "partner":"5h54" }, { "sim":51.0, - "partner":"5h54" + "partner":"5h5a" }, { "sim":51.0, @@ -551870,23 +553971,23 @@ }, { "sim":51.0, - "partner":"5tgs" + "partner":"1ig3" }, { "sim":51.0, - "partner":"1ig3" + "partner":"2f17" }, { "sim":51.0, - "partner":"7e16" + "partner":"5th5" }, { "sim":51.0, - "partner":"2f17" + "partner":"5tgs" }, { "sim":51.0, - "partner":"5th5" + "partner":"7e16" }, { "sim":51.0, @@ -551896,10 +553997,6 @@ "sim":51.0, "partner":"4qts" }, - { - "sim":51.0, - "partner":"4ke6" - }, { "sim":51.0, "partner":"4ke7" @@ -551922,11 +554019,7 @@ }, { "sim":51.0, - "partner":"5ds3" - }, - { - "sim":51.0, - "partner":"6bhv" + "partner":"4ke6" }, { "sim":51.0, @@ -551954,7 +554047,11 @@ }, { "sim":51.0, - "partner":"5tii" + "partner":"6bhv" + }, + { + "sim":51.0, + "partner":"5ds3" }, { "sim":51.0, @@ -551962,15 +554059,15 @@ }, { "sim":51.0, - "partner":"2zvw" + "partner":"5tii" }, { "sim":51.0, - "partner":"5w1q" + "partner":"2zvw" }, { "sim":51.0, - "partner":"3dbp" + "partner":"5w1q" }, { "sim":51.0, @@ -551988,6 +554085,10 @@ "sim":51.0, "partner":"3g3m" }, + { + "sim":51.0, + "partner":"3dbp" + }, { "sim":51.0, "partner":"1y0x" @@ -552082,11 +554183,11 @@ }, { "sim":51.0, - "partner":"4rdh" + "partner":"4rdi" }, { "sim":51.0, - "partner":"4rdi" + "partner":"4rdh" }, { "sim":51.0, @@ -552114,11 +554215,11 @@ }, { "sim":51.0, - "partner":"3ta4" + "partner":"3t9w" }, { "sim":51.0, - "partner":"3t9w" + "partner":"3ta4" }, { "sim":51.0, @@ -552136,10 +554237,6 @@ "sim":51.0, "partner":"5l4l" }, - { - "sim":51.0, - "partner":"3g3d" - }, { "sim":51.0, "partner":"3bvj" @@ -552156,6 +554253,10 @@ "sim":51.0, "partner":"4hkp" }, + { + "sim":51.0, + "partner":"3g3d" + }, { "sim":51.0, "partner":"6oxh" @@ -552212,10 +554313,6 @@ "sim":51.0, "partner":"4xrt" }, - { - "sim":51.0, - "partner":"2pzm" - }, { "sim":51.0, "partner":"2pzk" @@ -552226,7 +554323,7 @@ }, { "sim":51.0, - "partner":"7btm" + "partner":"2pzm" }, { "sim":51.0, @@ -552234,15 +554331,19 @@ }, { "sim":51.0, - "partner":"1w2n" + "partner":"7btm" }, { "sim":51.0, - "partner":"1w2o" + "partner":"6djt" }, { "sim":51.0, - "partner":"6djt" + "partner":"1w2n" + }, + { + "sim":51.0, + "partner":"1w2o" }, { "sim":51.0, @@ -552288,25 +554389,17 @@ "sim":51.0, "partner":"2fg7" }, - { - "sim":51.0, - "partner":"6q4x" - }, - { - "sim":51.0, - "partner":"6q4y" - }, { "sim":51.0, "partner":"6q4z" }, { "sim":51.0, - "partner":"5gg5" + "partner":"6q4x" }, { "sim":51.0, - "partner":"5xd1" + "partner":"6q4y" }, { "sim":51.0, @@ -552322,27 +554415,27 @@ }, { "sim":51.0, - "partner":"5gg7" + "partner":"6m6y" }, { "sim":51.0, - "partner":"5xd4" + "partner":"5gg7" }, { "sim":51.0, - "partner":"5xd5" + "partner":"5xd4" }, { "sim":51.0, - "partner":"6m6y" + "partner":"6m65" }, { "sim":51.0, - "partner":"5gg8" + "partner":"5xd5" }, { "sim":51.0, - "partner":"6m65" + "partner":"5gg8" }, { "sim":51.0, @@ -552374,19 +554467,23 @@ }, { "sim":51.0, - "partner":"5hs4" + "partner":"5gg5" }, { "sim":51.0, - "partner":"5hto" + "partner":"5xd1" }, { "sim":51.0, - "partner":"5hru" + "partner":"5hs4" }, { "sim":51.0, - "partner":"5l9l" + "partner":"5hto" + }, + { + "sim":51.0, + "partner":"5hru" }, { "sim":51.0, @@ -552410,11 +554507,11 @@ }, { "sim":51.0, - "partner":"5v8y" + "partner":"5l9l" }, { "sim":51.0, - "partner":"5jyf" + "partner":"5v8y" }, { "sim":51.0, @@ -552444,6 +554541,10 @@ "sim":51.0, "partner":"5jye" }, + { + "sim":51.0, + "partner":"5jyf" + }, { "sim":51.0, "partner":"4ilk" @@ -552454,23 +554555,23 @@ }, { "sim":51.0, - "partner":"6fm0" + "partner":"6fm3" }, { "sim":51.0, - "partner":"6rm2" + "partner":"6flf" }, { "sim":51.0, - "partner":"6fko" + "partner":"6fm0" }, { "sim":51.0, - "partner":"6fm3" + "partner":"6rm2" }, { "sim":51.0, - "partner":"6flf" + "partner":"6fko" }, { "sim":51.0, @@ -552566,19 +554667,19 @@ }, { "sim":51.0, - "partner":"4bvq" + "partner":"4bvs" }, { "sim":51.0, - "partner":"4bvr" + "partner":"4bvt" }, { "sim":51.0, - "partner":"4bvs" + "partner":"4bvq" }, { "sim":51.0, - "partner":"4bvt" + "partner":"4bvr" }, { "sim":51.0, @@ -552590,11 +554691,11 @@ }, { "sim":51.0, - "partner":"2elb" + "partner":"7dib" }, { "sim":51.0, - "partner":"7dib" + "partner":"2elb" }, { "sim":51.0, @@ -552608,10 +554709,6 @@ "sim":51.0, "partner":"6eqz" }, - { - "sim":51.0, - "partner":"6s0g" - }, { "sim":51.0, "partner":"7bn6" @@ -552622,7 +554719,7 @@ }, { "sim":51.0, - "partner":"4hcl" + "partner":"6s0g" }, { "sim":51.0, @@ -552644,6 +554741,10 @@ "sim":51.0, "partner":"4hch" }, + { + "sim":51.0, + "partner":"4hcl" + }, { "sim":51.0, "partner":"6m7l" @@ -552704,10 +554805,6 @@ "sim":51.0, "partner":"4bko" }, - { - "sim":51.0, - "partner":"4euh" - }, { "sim":51.0, "partner":"4ggv" @@ -552720,6 +554817,10 @@ "sim":51.0, "partner":"4euf" }, + { + "sim":51.0, + "partner":"4euh" + }, { "sim":51.0, "partner":"1pie" @@ -552758,39 +554859,39 @@ }, { "sim":51.0, - "partner":"5z8a" + "partner":"5z8k" }, { "sim":51.0, - "partner":"5z8k" + "partner":"5z83" }, { "sim":51.0, - "partner":"5z83" + "partner":"5z8a" }, { "sim":51.0, - "partner":"6ry0" + "partner":"6ry5" }, { "sim":51.0, - "partner":"6ry1" + "partner":"6ry6" }, { "sim":51.0, - "partner":"6ry2" + "partner":"6ry7" }, { "sim":51.0, - "partner":"6ry5" + "partner":"6ry0" }, { "sim":51.0, - "partner":"6ry6" + "partner":"6ry1" }, { "sim":51.0, - "partner":"6ry7" + "partner":"6ry2" }, { "sim":51.0, @@ -552824,10 +554925,6 @@ "sim":51.0, "partner":"4buc" }, - { - "sim":51.0, - "partner":"2z67" - }, { "sim":51.0, "partner":"4dcs" @@ -552844,6 +554941,10 @@ "sim":51.0, "partner":"4dcv" }, + { + "sim":51.0, + "partner":"2z67" + }, { "sim":51.0, "partner":"2yl9" @@ -552854,11 +554955,11 @@ }, { "sim":51.0, - "partner":"6f47" + "partner":"6f4e" }, { "sim":51.0, - "partner":"6f4e" + "partner":"6f47" }, { "sim":51.0, @@ -552894,11 +554995,11 @@ }, { "sim":51.0, - "partner":"4dqv" + "partner":"4u5q" }, { "sim":51.0, - "partner":"4u5q" + "partner":"4dqv" }, { "sim":51.0, @@ -552940,10 +555041,6 @@ "sim":51.0, "partner":"7tom" }, - { - "sim":51.0, - "partner":"5kdn" - }, { "sim":51.0, "partner":"5kds" @@ -552954,11 +555051,11 @@ }, { "sim":51.0, - "partner":"2w5f" + "partner":"5kdn" }, { "sim":51.0, - "partner":"2r0p" + "partner":"2w5f" }, { "sim":51.0, @@ -552974,7 +555071,7 @@ }, { "sim":51.0, - "partner":"2q5l" + "partner":"2r0p" }, { "sim":51.0, @@ -552994,19 +555091,19 @@ }, { "sim":51.0, - "partner":"6dqx" + "partner":"2q5l" }, { "sim":51.0, - "partner":"6j1f" + "partner":"6dqx" }, { "sim":51.0, - "partner":"7z7h" + "partner":"6j1f" }, { "sim":51.0, - "partner":"6j1e" + "partner":"7z7h" }, { "sim":51.0, @@ -553028,6 +555125,10 @@ "sim":51.0, "partner":"6j0p" }, + { + "sim":51.0, + "partner":"6j1e" + }, { "sim":51.0, "partner":"6xxw" @@ -553066,16 +555167,12 @@ }, { "sim":51.0, - "partner":"5uw0" + "partner":"5uw1" }, { "sim":51.0, "partner":"5vnc" }, - { - "sim":51.0, - "partner":"5uw1" - }, { "sim":51.0, "partner":"5uw4" @@ -553086,7 +555183,7 @@ }, { "sim":51.0, - "partner":"3rsz" + "partner":"5uw0" }, { "sim":51.0, @@ -553116,6 +555213,10 @@ "sim":51.0, "partner":"3nch" }, + { + "sim":51.0, + "partner":"3rsz" + }, { "sim":51.0, "partner":"2d73" @@ -553178,11 +555279,11 @@ }, { "sim":51.0, - "partner":"5faw" + "partner":"6vue" }, { "sim":51.0, - "partner":"6vue" + "partner":"5faw" }, { "sim":51.0, @@ -553348,17 +555449,13 @@ "sim":50.0, "partner":"3oq0" }, - { - "sim":50.0, - "partner":"3faj" - }, { "sim":50.0, "partner":"7dvi" }, { "sim":50.0, - "partner":"3rg6" + "partner":"3faj" }, { "sim":50.0, @@ -553372,6 +555469,10 @@ "sim":50.0, "partner":"2peo" }, + { + "sim":50.0, + "partner":"3rg6" + }, { "sim":50.0, "partner":"4zwt" @@ -553406,11 +555507,11 @@ }, { "sim":50.0, - "partner":"5uh7" + "partner":"6srt" }, { "sim":50.0, - "partner":"6srt" + "partner":"5uh7" }, { "sim":50.0, @@ -553444,14 +555545,6 @@ "sim":50.0, "partner":"3kh9" }, - { - "sim":50.0, - "partner":"5scp" - }, - { - "sim":50.0, - "partner":"5scq" - }, { "sim":50.0, "partner":"5scr" @@ -553554,12 +555647,20 @@ }, { "sim":50.0, - "partner":"5k24" + "partner":"5scp" + }, + { + "sim":50.0, + "partner":"5scq" }, { "sim":50.0, "partner":"5k22" }, + { + "sim":50.0, + "partner":"5k24" + }, { "sim":50.0, "partner":"5gqo" @@ -553592,10 +555693,6 @@ "sim":50.0, "partner":"2i2w" }, - { - "sim":50.0, - "partner":"5bnq" - }, { "sim":50.0, "partner":"3me2" @@ -553606,11 +555703,11 @@ }, { "sim":50.0, - "partner":"3umf" + "partner":"5bnq" }, { "sim":50.0, - "partner":"2fzl" + "partner":"3umf" }, { "sim":50.0, @@ -553632,6 +555729,10 @@ "sim":50.0, "partner":"1wc5" }, + { + "sim":50.0, + "partner":"2fzl" + }, { "sim":50.0, "partner":"3l4c" @@ -553674,15 +555775,15 @@ }, { "sim":50.0, - "partner":"6z0x" + "partner":"6z0y" }, { "sim":50.0, - "partner":"6z0y" + "partner":"6z0e" }, { "sim":50.0, - "partner":"6z0e" + "partner":"6z0x" }, { "sim":50.0, @@ -553726,11 +555827,11 @@ }, { "sim":50.0, - "partner":"6ey1" + "partner":"6f0w" }, { "sim":50.0, - "partner":"6f0w" + "partner":"6ey1" }, { "sim":50.0, @@ -553756,10 +555857,6 @@ "sim":50.0, "partner":"6azo" }, - { - "sim":50.0, - "partner":"3vms" - }, { "sim":50.0, "partner":"3vmt" @@ -553774,7 +555871,7 @@ }, { "sim":50.0, - "partner":"3k8e" + "partner":"3vms" }, { "sim":50.0, @@ -553782,27 +555879,31 @@ }, { "sim":50.0, - "partner":"6ihr" + "partner":"3k8e" }, { "sim":50.0, - "partner":"6iht" + "partner":"6ihv" }, { "sim":50.0, - "partner":"6ihu" + "partner":"6ihw" }, { "sim":50.0, - "partner":"6ihv" + "partner":"5du0" }, { "sim":50.0, - "partner":"6ihw" + "partner":"6ihr" }, { "sim":50.0, - "partner":"5du0" + "partner":"6iht" + }, + { + "sim":50.0, + "partner":"6ihu" }, { "sim":50.0, @@ -553830,35 +555931,35 @@ }, { "sim":50.0, - "partner":"6ub4" + "partner":"5b1y" }, { "sim":50.0, - "partner":"4m7t" + "partner":"6ub2" }, { "sim":50.0, - "partner":"6ub5" + "partner":"6ub3" }, { "sim":50.0, - "partner":"6ub6" + "partner":"6ub4" }, { "sim":50.0, - "partner":"5b1y" + "partner":"6ub5" }, { "sim":50.0, - "partner":"6ub2" + "partner":"6ub6" }, { "sim":50.0, - "partner":"6ub3" + "partner":"4m7t" }, { "sim":50.0, - "partner":"1z5z" + "partner":"6non" }, { "sim":50.0, @@ -553866,15 +555967,15 @@ }, { "sim":50.0, - "partner":"6non" + "partner":"2f9w" }, { "sim":50.0, - "partner":"2f9w" + "partner":"5umi" }, { "sim":50.0, - "partner":"5umi" + "partner":"1z5z" }, { "sim":50.0, @@ -554058,11 +556159,11 @@ }, { "sim":50.0, - "partner":"3ws7" + "partner":"6pwn" }, { "sim":50.0, - "partner":"6pwn" + "partner":"6uzh" }, { "sim":50.0, @@ -554082,11 +556183,11 @@ }, { "sim":50.0, - "partner":"6uzh" + "partner":"3w6z" }, { "sim":50.0, - "partner":"3w6z" + "partner":"3ws7" }, { "sim":50.0, @@ -554094,15 +556195,15 @@ }, { "sim":50.0, - "partner":"1g8o" + "partner":"3zgd" }, { "sim":50.0, - "partner":"1fg5" + "partner":"1g8o" }, { "sim":50.0, - "partner":"3zgd" + "partner":"1fg5" }, { "sim":50.0, @@ -554126,27 +556227,27 @@ }, { "sim":50.0, - "partner":"3tmc" + "partner":"2qhx" }, { "sim":50.0, - "partner":"3tmd" + "partner":"3tm8" }, { "sim":50.0, - "partner":"2qhx" + "partner":"3tmb" }, { "sim":50.0, - "partner":"3tm8" + "partner":"6unx" }, { "sim":50.0, - "partner":"3tmb" + "partner":"3tmc" }, { "sim":50.0, - "partner":"6unx" + "partner":"3tmd" }, { "sim":50.0, @@ -554202,11 +556303,11 @@ }, { "sim":50.0, - "partner":"7epr" + "partner":"7eps" }, { "sim":50.0, - "partner":"7eps" + "partner":"7epr" }, { "sim":50.0, @@ -554228,33 +556329,17 @@ "sim":50.0, "partner":"2wt2" }, - { - "sim":50.0, - "partner":"6cwo" - }, { "sim":50.0, "partner":"5m8e" }, { "sim":50.0, - "partner":"3rny" - }, - { - "sim":50.0, - "partner":"1t9s" - }, - { - "sim":50.0, - "partner":"3sie" - }, - { - "sim":50.0, - "partner":"4g2w" + "partner":"6cwo" }, { "sim":50.0, - "partner":"4g2y" + "partner":"3rny" }, { "sim":50.0, @@ -554306,51 +556391,51 @@ }, { "sim":50.0, - "partner":"7kwm" + "partner":"3sie" }, { "sim":50.0, - "partner":"7cxs" + "partner":"1t9s" }, { "sim":50.0, - "partner":"7cxu" + "partner":"4g2w" }, { "sim":50.0, - "partner":"7cxv" + "partner":"4g2y" }, { "sim":50.0, - "partner":"7ajm" + "partner":"7kwm" }, { "sim":50.0, - "partner":"7a4r" + "partner":"7cxs" }, { "sim":50.0, - "partner":"7ajs" + "partner":"7cxu" }, { "sim":50.0, - "partner":"7a52" + "partner":"7cxv" }, { "sim":50.0, - "partner":"6nxc" + "partner":"7a4r" }, { "sim":50.0, - "partner":"8wpo" + "partner":"7ajs" }, { "sim":50.0, - "partner":"8wph" + "partner":"7a52" }, { "sim":50.0, - "partner":"8wpi" + "partner":"7ajm" }, { "sim":50.0, @@ -554366,51 +556451,47 @@ }, { "sim":50.0, - "partner":"8wps" - }, - { - "sim":50.0, - "partner":"2p2n" + "partner":"6nxc" }, { "sim":50.0, - "partner":"6nxd" + "partner":"8wps" }, { "sim":50.0, - "partner":"2p2d" + "partner":"8wpo" }, { "sim":50.0, - "partner":"2him" + "partner":"8wph" }, { "sim":50.0, - "partner":"3wmw" + "partner":"8wpi" }, { "sim":50.0, - "partner":"3wmx" + "partner":"2p2n" }, { "sim":50.0, - "partner":"7a53" + "partner":"6nxd" }, { "sim":50.0, - "partner":"7ajw" + "partner":"2p2d" }, { "sim":50.0, - "partner":"7akb" + "partner":"2him" }, { "sim":50.0, - "partner":"7ajy" + "partner":"3wmw" }, { "sim":50.0, - "partner":"7a5l" + "partner":"3wmx" }, { "sim":50.0, @@ -554472,10 +556553,30 @@ "sim":50.0, "partner":"7aka" }, + { + "sim":50.0, + "partner":"7a53" + }, { "sim":50.0, "partner":"7akl" }, + { + "sim":50.0, + "partner":"7ajw" + }, + { + "sim":50.0, + "partner":"7akb" + }, + { + "sim":50.0, + "partner":"7ajy" + }, + { + "sim":50.0, + "partner":"7a5l" + }, { "sim":50.0, "partner":"1xoz" @@ -554508,14 +556609,6 @@ "sim":50.0, "partner":"6j28" }, - { - "sim":50.0, - "partner":"4q3r" - }, - { - "sim":50.0, - "partner":"4q42" - }, { "sim":50.0, "partner":"4q3s" @@ -554548,6 +556641,14 @@ "sim":50.0, "partner":"4q41" }, + { + "sim":50.0, + "partner":"4q3r" + }, + { + "sim":50.0, + "partner":"4q42" + }, { "sim":50.0, "partner":"4wwv" @@ -554622,11 +556723,11 @@ }, { "sim":50.0, - "partner":"5xw2" + "partner":"4e2p" }, { "sim":50.0, - "partner":"4e2p" + "partner":"5xw2" }, { "sim":50.0, @@ -554644,10 +556745,6 @@ "sim":50.0, "partner":"5hxk" }, - { - "sim":50.0, - "partner":"5cu7" - }, { "sim":50.0, "partner":"4fdt" @@ -554662,19 +556759,19 @@ }, { "sim":50.0, - "partner":"5kyo" + "partner":"5cu7" }, { "sim":50.0, - "partner":"2alm" + "partner":"5kyo" }, { "sim":50.0, - "partner":"4lcl" + "partner":"2alm" }, { "sim":50.0, - "partner":"3amu" + "partner":"4lcl" }, { "sim":50.0, @@ -554682,11 +556779,11 @@ }, { "sim":50.0, - "partner":"4kp2" + "partner":"3amu" }, { "sim":50.0, - "partner":"2imc" + "partner":"4kp2" }, { "sim":50.0, @@ -554714,11 +556811,11 @@ }, { "sim":50.0, - "partner":"4kp1" + "partner":"2imc" }, { "sim":50.0, - "partner":"7lr2" + "partner":"4kp1" }, { "sim":50.0, @@ -554730,11 +556827,7 @@ }, { "sim":50.0, - "partner":"6mp7" - }, - { - "sim":50.0, - "partner":"6mpa" + "partner":"7lr2" }, { "sim":50.0, @@ -554752,6 +556845,14 @@ "sim":50.0, "partner":"7c7r" }, + { + "sim":50.0, + "partner":"6mp7" + }, + { + "sim":50.0, + "partner":"6mpa" + }, { "sim":50.0, "partner":"4yiw" @@ -554768,10 +556869,6 @@ "sim":50.0, "partner":"5upl" }, - { - "sim":50.0, - "partner":"2r98" - }, { "sim":50.0, "partner":"2r8v" @@ -554792,6 +556889,10 @@ "sim":50.0, "partner":"4i49" }, + { + "sim":50.0, + "partner":"2r98" + }, { "sim":50.0, "partner":"3qfs" @@ -554892,14 +556993,6 @@ "sim":50.0, "partner":"2v6e" }, - { - "sim":50.0, - "partner":"4ids" - }, - { - "sim":50.0, - "partner":"4jdc" - }, { "sim":50.0, "partner":"4lem" @@ -554918,7 +557011,11 @@ }, { "sim":50.0, - "partner":"5wm2" + "partner":"4ids" + }, + { + "sim":50.0, + "partner":"4jdc" }, { "sim":50.0, @@ -554940,6 +557037,10 @@ "sim":50.0, "partner":"5wm7" }, + { + "sim":50.0, + "partner":"5wm2" + }, { "sim":50.0, "partner":"3bdl" @@ -554974,15 +557075,15 @@ }, { "sim":50.0, - "partner":"7w1c" + "partner":"7w1d" }, { "sim":50.0, - "partner":"7w1d" + "partner":"7w1e" }, { "sim":50.0, - "partner":"7w1e" + "partner":"7w1c" }, { "sim":50.0, @@ -555018,15 +557119,15 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"6edz" }, { "sim":50.0, - "partner":"6edz" + "partner":"6ee1" }, { "sim":50.0, - "partner":"6ee1" + "partner":"6edw" }, { "sim":50.0, @@ -555218,13 +557319,13 @@ "subtitle":"Crystal structure of pizza6-tnk-rsh with silicotungstic acid (sta) polyoxometalate", "tags":[ "silicotungstic acid", - "beta propeller", - "synthetic", + "sta", "co-crystal", - "unknown function", - "designer", "polyoxometalate", - "sta" + "synthetic", + "unknown function", + "beta propeller", + "designer" ], "keywords":[ "description", @@ -555285,19 +557386,19 @@ }, { "sim":476.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":476.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":476.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":476.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":476.0, @@ -555305,11 +557406,11 @@ }, { "sim":476.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":476.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":476.0, @@ -555317,7 +557418,7 @@ }, { "sim":476.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":471.0, @@ -555325,15 +557426,15 @@ }, { "sim":471.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":471.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":471.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":471.0, @@ -555353,19 +557454,19 @@ }, { "sim":451.0, - "partner":"6i3a" + "partner":"6i38" }, { "sim":451.0, - "partner":"6i38" + "partner":"6i3a" }, { "sim":446.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":446.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":446.0, @@ -555373,7 +557474,7 @@ }, { "sim":446.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":430.0, @@ -555381,11 +557482,11 @@ }, { "sim":159.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":159.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":158.0, @@ -555403,11 +557504,11 @@ "seq_thr_sim_natural":[ { "sim":329.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":329.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":99.0, @@ -555491,15 +557592,15 @@ }, { "sim":60.0, - "partner":"8dvn" + "partner":"8dvl" }, { "sim":60.0, - "partner":"8dvl" + "partner":"8dvm" }, { "sim":60.0, - "partner":"8dvm" + "partner":"8dvn" }, { "sim":55.0, @@ -555551,11 +557652,11 @@ }, { "sim":50.0, - "partner":"3soq" + "partner":"3sov" }, { "sim":50.0, - "partner":"3sov" + "partner":"3soq" } ], "struct_thr_sim_designed":[ @@ -555649,7 +557750,7 @@ }, "seq_max_sim_natural":{ "sim":329.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9815000296, @@ -555716,13 +557817,13 @@ "subtitle":"Crystal structure of pizza6-tsk-tsh with silicotungstic acid (sta) polyoxometalate", "tags":[ "silicotungstic acid", - "beta propeller", - "synthetic", + "sta", "co-crystal", - "unknown function", - "designer", "polyoxometalate", - "sta" + "synthetic", + "unknown function", + "beta propeller", + "designer" ], "keywords":[ "description", @@ -555783,19 +557884,19 @@ }, { "sim":487.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":487.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":487.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":487.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":487.0, @@ -555803,11 +557904,11 @@ }, { "sim":487.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":487.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":487.0, @@ -555815,7 +557916,7 @@ }, { "sim":487.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":482.0, @@ -555827,15 +557928,15 @@ }, { "sim":481.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":481.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":481.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":481.0, @@ -555859,11 +557960,11 @@ }, { "sim":456.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":456.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":456.0, @@ -555871,7 +557972,7 @@ }, { "sim":456.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":440.0, @@ -555887,11 +557988,11 @@ }, { "sim":160.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":160.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":159.0, @@ -555901,11 +558002,11 @@ "seq_thr_sim_natural":[ { "sim":332.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":332.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":94.0, @@ -555989,15 +558090,15 @@ }, { "sim":58.0, - "partner":"8dvn" + "partner":"8dvl" }, { "sim":58.0, - "partner":"8dvl" + "partner":"8dvm" }, { "sim":58.0, - "partner":"8dvm" + "partner":"8dvn" }, { "sim":58.0, @@ -556147,7 +558248,7 @@ }, "seq_max_sim_natural":{ "sim":332.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.996999979, @@ -556214,13 +558315,13 @@ "subtitle":"Crystal structure of pizza6-tsr-tsh with silicotungstic acid (sta) polyoxometalate", "tags":[ "silicotungstic acid", - "beta propeller", - "synthetic", + "sta", "co-crystal", - "unknown function", - "designer", "polyoxometalate", - "sta" + "synthetic", + "unknown function", + "beta propeller", + "designer" ], "keywords":[ "description", @@ -556281,19 +558382,19 @@ }, { "sim":488.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":488.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":488.0, - "partner":"7ov7" + "partner":"6qse" }, { "sim":488.0, - "partner":"6rei" + "partner":"6reg" }, { "sim":488.0, @@ -556301,11 +558402,11 @@ }, { "sim":488.0, - "partner":"6reh" + "partner":"6qsg" }, { "sim":488.0, - "partner":"6qsg" + "partner":"6qsh" }, { "sim":488.0, @@ -556313,7 +558414,7 @@ }, { "sim":488.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":483.0, @@ -556325,15 +558426,15 @@ }, { "sim":482.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":482.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":482.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":482.0, @@ -556357,11 +558458,11 @@ }, { "sim":458.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":458.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":458.0, @@ -556369,7 +558470,7 @@ }, { "sim":458.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":441.0, @@ -556385,11 +558486,11 @@ }, { "sim":161.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":161.0, - "partner":"5i1z" + "partner":"5i1y" }, { "sim":160.0, @@ -556399,11 +558500,11 @@ "seq_thr_sim_natural":[ { "sim":333.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":333.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":94.0, @@ -556487,15 +558588,15 @@ }, { "sim":58.0, - "partner":"8dvn" + "partner":"8dvl" }, { "sim":58.0, - "partner":"8dvl" + "partner":"8dvm" }, { "sim":58.0, - "partner":"8dvm" + "partner":"8dvn" }, { "sim":58.0, @@ -556633,7 +558734,7 @@ }, "seq_max_sim_natural":{ "sim":333.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9896000028, @@ -556700,13 +558801,13 @@ "subtitle":"Crystal structure of pizza6-rsh-tsh with silicotungstic acid (sta) polyoxometalate", "tags":[ "silicotungstic acid", - "beta propeller", - "synthetic", + "sta", "co-crystal", - "unknown function", - "designer", "polyoxometalate", - "sta" + "synthetic", + "unknown function", + "beta propeller", + "designer" ], "keywords":[ "description", @@ -556755,43 +558856,43 @@ }, { "sim":490.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":490.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":490.0, - "partner":"7zpz" + "partner":"6qse" }, { "sim":490.0, - "partner":"7ov7" + "partner":"6reg" }, { "sim":490.0, - "partner":"6rei" + "partner":"6qsf" }, { "sim":490.0, - "partner":"6qsf" + "partner":"6qsg" }, { "sim":490.0, - "partner":"6reh" + "partner":"6qsh" }, { "sim":490.0, - "partner":"6qsg" + "partner":"6qsd" }, { "sim":490.0, - "partner":"6qsd" + "partner":"7zpz" }, { "sim":490.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":489.0, @@ -556803,15 +558904,15 @@ }, { "sim":485.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":485.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":485.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":485.0, @@ -556843,11 +558944,11 @@ }, { "sim":460.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":460.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":460.0, @@ -556855,7 +558956,7 @@ }, { "sim":460.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":444.0, @@ -556863,19 +558964,19 @@ }, { "sim":162.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":162.0, - "partner":"5f53" + "partner":"5i1y" }, { "sim":162.0, - "partner":"4zcn" + "partner":"5f53" }, { "sim":162.0, - "partner":"5i1z" + "partner":"4zcn" }, { "sim":160.0, @@ -556885,11 +558986,11 @@ "seq_thr_sim_natural":[ { "sim":333.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":333.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":96.0, @@ -556965,15 +559066,15 @@ }, { "sim":60.0, - "partner":"8dvn" + "partner":"8dvl" }, { "sim":60.0, - "partner":"8dvl" + "partner":"8dvm" }, { "sim":60.0, - "partner":"8dvm" + "partner":"8dvn" }, { "sim":59.0, @@ -557087,7 +559188,7 @@ }, "seq_max_sim_natural":{ "sim":333.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9731000066, @@ -557205,123 +559306,123 @@ ], "subtitle":"Velcrovax tandem hbcag with sumo-affimer inserted at mir (t=4 vlp)", "tags":[ - "virus like particle", - "velcrovax", + "recombinant", + "hepatitis b virus", "vaccine", - "antigen display", + "velcrovax", "affimer", "vlp", - "hepatitis b virus", - "hepatitis b core antigen", - "recombinant" + "virus like particle", + "antigen display", + "hepatitis b core antigen" ], "keywords":[ - "immunogenic", - "utilize", - "junv", - "use", - "glycoprotein", + "superior", + "papillomavirus", + "responses", "noninfectious", - "manufacture", - "allowing", - "immune", - "vlp", - "particles", - "target", - "expression", - "basis", + "unrelated", + "structural", "therefore", - "needs", - "vaccine", - "able", - "molecule", - "adapted", - "strategies", - "proteins", - "viral", + "varied", + "vaccines", + "sumo", + "core", + "newly", + "hbcag", + "rapidly", + "noncomplexed", + "particles", + "candidates", + "hepatitis", + "model", + "protein", + "propose", + "binding", + "vaccination", + "produced", + "b", "forms", - "solved", - "hbc", - "papillomavirus", - "arenavirus", + "two", + "vlp", + "using", + "utilize", + "junv", + "complex", + "licensed", "tag", - "nanoparticles", - "rapidly", - "separately", - "easily", - "assemble", - "structures", - "capture", - "foundation", + "nanoparticle", + "able", + "humoral", "recombinant", - "future", - "respond", + "capture", + "termed", + "basis", + "hbc", + "bound", + "proteins", + "arenavirus", "affimer", - "form", + "use", + "future", + "importance", + "allowing", + "molecule", + "surface", + "design", + "critical", + "glycoprotein", "compared", - "first", + "provides", + "nanoparticles", + "manufacture", "platform", - "licensed", - "responses", - "hepatitis", - "newly", + "tagged", + "respond", + "velcrovax", "virus", - "hbv", - "antigens", - "jun\u00edn", - "generate", - "antigen", - "gp1", - "vaccination", - "approaches", + "easily", "successful", + "immune", "shown", - "induces", - "universal", - "provides", - "vlps", - "design", - "produced", - "core", - "model", - "nanoparticle", - "using", + "jun\u00edn", + "pathogens", + "foundation", + "viral", "suitably", + "separately", + "needs", + "sequence", + "system", + "solved", "present", - "propose", - "surface", + "vaccine", "describe", - "sequence", - "sumo", + "range", + "universal", "could", - "candidates", - "capturing", + "form", + "hbv", + "directed", + "vlps", + "immunogenic", + "strategies", + "structures", + "approaches", + "first", + "antigens", + "antigen", + "generate", + "target", + "gp1", "worldwide", - "structural", - "range", - "importance", - "critical", - "termed", "modified", - "noncomplexed", - "velcrovax", + "expression", + "assemble", "human", - "directed", - "pathogens", - "tagged", - "hbcag", - "unrelated", - "two", - "system", - "varied", - "b", - "protein", - "bound", - "complex", - "superior", - "humoral", - "vaccines", - "binding", + "capturing", + "adapted", + "induces", "emerging" ], "release_date":"2023-01-18", @@ -557363,11 +559464,11 @@ }, { "sim":131.0, - "partner":"4n6t" + "partner":"4n6u" }, { "sim":131.0, - "partner":"4n6u" + "partner":"4n6t" } ], "seq_thr_sim_natural":[ @@ -557401,11 +559502,11 @@ }, { "sim":353.0, - "partner":"7pzk" + "partner":"6htx" }, { "sim":353.0, - "partner":"6htx" + "partner":"7pzk" }, { "sim":353.0, @@ -557441,31 +559542,31 @@ }, { "sim":349.0, - "partner":"8uyv" + "partner":"8uyz" }, { "sim":349.0, - "partner":"8uyw" + "partner":"7oen" }, { "sim":349.0, - "partner":"8uyy" + "partner":"8uyv" }, { "sim":349.0, - "partner":"7oen" + "partner":"7pzm" }, { "sim":349.0, - "partner":"8uyz" + "partner":"8uyw" }, { "sim":349.0, - "partner":"7pzm" + "partner":"7ocw" }, { "sim":349.0, - "partner":"7ocw" + "partner":"8uyy" }, { "sim":347.0, @@ -557551,10 +559652,6 @@ "sim":290.0, "partner":"5d7y" }, - { - "sim":289.0, - "partner":"6bvf" - }, { "sim":289.0, "partner":"2g33" @@ -557575,6 +559672,10 @@ "sim":289.0, "partner":"6bvn" }, + { + "sim":289.0, + "partner":"6bvf" + }, { "sim":289.0, "partner":"3v6z" @@ -557597,11 +559698,11 @@ }, { "sim":281.0, - "partner":"7ep6" + "partner":"7eoy" }, { "sim":281.0, - "partner":"7eoy" + "partner":"7ep6" }, { "sim":265.0, @@ -557721,11 +559822,11 @@ }, { "sim":99.0, - "partner":"3ul6" + "partner":"3ul5" }, { "sim":99.0, - "partner":"3ul5" + "partner":"3ul6" }, { "sim":96.0, @@ -557893,123 +559994,123 @@ ], "subtitle":"Velcrovax tandem hbcag with sumo-affimer inserted at mir (t=3* vlp)", "tags":[ - "virus like particle", - "velcrovax", + "recombinant", + "hepatitis b virus", "vaccine", - "antigen display", + "velcrovax", "affimer", "vlp", - "hepatitis b virus", - "hepatitis b core antigen", - "recombinant" + "virus like particle", + "antigen display", + "hepatitis b core antigen" ], "keywords":[ - "immunogenic", - "utilize", - "junv", - "use", - "glycoprotein", + "superior", + "papillomavirus", + "responses", "noninfectious", - "manufacture", - "allowing", - "immune", - "vlp", - "particles", - "target", - "expression", - "basis", + "unrelated", + "structural", "therefore", - "needs", - "vaccine", - "able", - "molecule", - "adapted", - "strategies", - "proteins", - "viral", + "varied", + "vaccines", + "sumo", + "core", + "newly", + "hbcag", + "rapidly", + "noncomplexed", + "particles", + "candidates", + "hepatitis", + "model", + "protein", + "propose", + "binding", + "vaccination", + "produced", + "b", "forms", - "solved", - "hbc", - "papillomavirus", - "arenavirus", + "two", + "vlp", + "using", + "utilize", + "junv", + "complex", + "licensed", "tag", - "nanoparticles", - "rapidly", - "separately", - "easily", - "assemble", - "structures", - "capture", - "foundation", + "nanoparticle", + "able", + "humoral", "recombinant", - "future", - "respond", + "capture", + "termed", + "basis", + "hbc", + "bound", + "proteins", + "arenavirus", "affimer", - "form", + "use", + "future", + "importance", + "allowing", + "molecule", + "surface", + "design", + "critical", + "glycoprotein", "compared", - "first", + "provides", + "nanoparticles", + "manufacture", "platform", - "licensed", - "responses", - "hepatitis", - "newly", + "tagged", + "respond", + "velcrovax", "virus", - "hbv", - "antigens", - "jun\u00edn", - "generate", - "antigen", - "gp1", - "vaccination", - "approaches", + "easily", "successful", + "immune", "shown", - "induces", - "universal", - "provides", - "vlps", - "design", - "produced", - "core", - "model", - "nanoparticle", - "using", + "jun\u00edn", + "pathogens", + "foundation", + "viral", "suitably", + "separately", + "needs", + "sequence", + "system", + "solved", "present", - "propose", - "surface", + "vaccine", "describe", - "sequence", - "sumo", + "range", + "universal", "could", - "candidates", - "capturing", + "form", + "hbv", + "directed", + "vlps", + "immunogenic", + "strategies", + "structures", + "approaches", + "first", + "antigens", + "antigen", + "generate", + "target", + "gp1", "worldwide", - "structural", - "range", - "importance", - "critical", - "termed", "modified", - "noncomplexed", - "velcrovax", + "expression", + "assemble", "human", - "directed", - "pathogens", - "tagged", - "hbcag", - "unrelated", - "two", - "system", - "varied", - "b", - "protein", - "bound", - "complex", - "superior", - "humoral", - "vaccines", - "binding", + "capturing", + "adapted", + "induces", "emerging" ], "release_date":"2023-01-18", @@ -558051,11 +560152,11 @@ }, { "sim":131.0, - "partner":"4n6t" + "partner":"4n6u" }, { "sim":131.0, - "partner":"4n6u" + "partner":"4n6t" } ], "seq_thr_sim_natural":[ @@ -558089,11 +560190,11 @@ }, { "sim":353.0, - "partner":"7pzk" + "partner":"6htx" }, { "sim":353.0, - "partner":"6htx" + "partner":"7pzk" }, { "sim":353.0, @@ -558129,31 +560230,31 @@ }, { "sim":349.0, - "partner":"8uyv" + "partner":"8uyz" }, { "sim":349.0, - "partner":"8uyw" + "partner":"7oen" }, { "sim":349.0, - "partner":"8uyy" + "partner":"8uyv" }, { "sim":349.0, - "partner":"7oen" + "partner":"7pzm" }, { "sim":349.0, - "partner":"8uyz" + "partner":"8uyw" }, { "sim":349.0, - "partner":"7pzm" + "partner":"7ocw" }, { "sim":349.0, - "partner":"7ocw" + "partner":"8uyy" }, { "sim":347.0, @@ -558239,10 +560340,6 @@ "sim":290.0, "partner":"5d7y" }, - { - "sim":289.0, - "partner":"6bvf" - }, { "sim":289.0, "partner":"2g33" @@ -558263,6 +560360,10 @@ "sim":289.0, "partner":"6bvn" }, + { + "sim":289.0, + "partner":"6bvf" + }, { "sim":289.0, "partner":"3v6z" @@ -558285,11 +560386,11 @@ }, { "sim":281.0, - "partner":"7ep6" + "partner":"7eoy" }, { "sim":281.0, - "partner":"7eoy" + "partner":"7ep6" }, { "sim":265.0, @@ -558409,11 +560510,11 @@ }, { "sim":99.0, - "partner":"3ul6" + "partner":"3ul5" }, { "sim":99.0, - "partner":"3ul5" + "partner":"3ul6" }, { "sim":96.0, @@ -558530,13 +560631,13 @@ "subtitle":"Crystal structure of pizza6-ksh-tsh with silicotungstic acid (sta) polyoxometalate", "tags":[ "silicotungstic acid", - "beta propeller", - "synthetic", + "sta", "co-crystal", - "unknown function", - "designer", "polyoxometalate", - "sta" + "synthetic", + "unknown function", + "beta propeller", + "designer" ], "keywords":[ "description", @@ -558585,43 +560686,43 @@ }, { "sim":490.0, - "partner":"6qsh" + "partner":"6rei" }, { "sim":490.0, - "partner":"6reg" + "partner":"6reh" }, { "sim":490.0, - "partner":"7zpz" + "partner":"6qse" }, { "sim":490.0, - "partner":"7ov7" + "partner":"6reg" }, { "sim":490.0, - "partner":"6rei" + "partner":"6qsf" }, { "sim":490.0, - "partner":"6qsf" + "partner":"6qsg" }, { "sim":490.0, - "partner":"6reh" + "partner":"6qsh" }, { "sim":490.0, - "partner":"6qsg" + "partner":"6qsd" }, { "sim":490.0, - "partner":"6qsd" + "partner":"7zpz" }, { "sim":490.0, - "partner":"6qse" + "partner":"7ov7" }, { "sim":489.0, @@ -558633,15 +560734,15 @@ }, { "sim":485.0, - "partner":"6rel" + "partner":"6rek" }, { "sim":485.0, - "partner":"6rek" + "partner":"6rem" }, { "sim":485.0, - "partner":"6rem" + "partner":"6rel" }, { "sim":485.0, @@ -558673,11 +560774,11 @@ }, { "sim":460.0, - "partner":"6reo" + "partner":"6rli" }, { "sim":460.0, - "partner":"6rli" + "partner":"6ren" }, { "sim":460.0, @@ -558685,7 +560786,7 @@ }, { "sim":460.0, - "partner":"6ren" + "partner":"6reo" }, { "sim":444.0, @@ -558693,19 +560794,19 @@ }, { "sim":162.0, - "partner":"5i1y" + "partner":"5i1z" }, { "sim":162.0, - "partner":"5f53" + "partner":"5i1y" }, { "sim":162.0, - "partner":"4zcn" + "partner":"5f53" }, { "sim":162.0, - "partner":"5i1z" + "partner":"4zcn" }, { "sim":160.0, @@ -558715,11 +560816,11 @@ "seq_thr_sim_natural":[ { "sim":334.0, - "partner":"1rwl" + "partner":"1rwi" }, { "sim":334.0, - "partner":"1rwi" + "partner":"1rwl" }, { "sim":93.0, @@ -558803,15 +560904,15 @@ }, { "sim":59.0, - "partner":"8dvn" + "partner":"8dvl" }, { "sim":59.0, - "partner":"8dvl" + "partner":"8dvm" }, { "sim":59.0, - "partner":"8dvm" + "partner":"8dvn" }, { "sim":57.0, @@ -558913,7 +561014,7 @@ }, "seq_max_sim_natural":{ "sim":334.0, - "partner":"1rwl" + "partner":"1rwi" }, "struct_max_sim_designed":{ "sim":0.9950000048, @@ -559079,110 +561180,110 @@ ], "subtitle":"Cryo-em structure of d614 spike in complex with de novo designed binder", "tags":[ + "receptor binding domain", + "de novo", "spike", "sars-cov2", "rbd", - "receptor binding domain", - "antiviral protein", - "de novo", - "design binder" + "design binder", + "antiviral protein" ], "keywords":[ - "engage", - "use", - "comprehensive", - "captures", - "designed", - "generated", - "experimentally", + "affinity", + "purely", + "molecular", + "fingerprints", + "recognition", + "optimized", + "structural", + "key", + "predictions", + "framework", + "new", + "drive", + "protein", + "accurate", + "cellular", + "essential", + "networks", + "novo", + "major", + "principle", + "applications", + "10", + "paradigm", "geometric", + "life", + "knowledge", + "however", "obstacle", - "features", - "interactions", - "synthetic", - "generates", - "represent", - "networks", + "governing", + "genomic", "computationally", - "broadly", - "proof", - "however", - "affinity", - "novel", + "enabling", + "experimentally", + "overall", + "biological", + "comprehensive", "crucial", - "even", - "interaction", - "reaching", + "capture", + "targets", + "surfaces", + "approach", + "showing", "proteins", - "hypothesized", - "de", - "translational", - "processes", + "characterization", + "several", + "use", "highly", - "binders", - "recognition", - "drive", - "nanomolar", - "life", - "capture", - "essential", - "function", - "cellular", - "physical", - "biology", - "framework", - "data", - "molecular", + "proof", + "spike", + "aspects", "chemical", - "predictions", - "others", + "physical", + "features", "four", - "genomic", - "accurate", - "artificial", + "nanomolar", + "computational", "1", + "increase", "challenging", - "10", - "surfaces", - "spike", - "several", "design", - "characterization", - "applications", - "describe", - "fingerprints", - "biological", - "increase", - "key", - "structural", - "enabling", - "operating", - "governing", - "designs", - "overall", "critical", - "optimized", - "aspects", - "showing", - "mutational", - "approach", - "gap", - "novo", - "principle", - "purely", - "understand", + "binders", + "even", + "biology", + "represent", + "processes", + "engage", + "captures", + "generates", + "interaction", + "broadly", + "whereas", "proteomic", + "describe", + "reaching", + "designed", "determinants", - "protein", - "targets", - "paradigm", - "knowledge", + "others", + "mutational", + "de", + "understand", + "translational", + "synthetic", + "interactions", + "function", "understanding", - "computational", "silico", - "major", - "new", - "whereas" + "artificial", + "operating", + "generated", + "gap", + "data", + "designs", + "hypothesized", + "novel" ], "release_date":"2023-03-01", "publication":"\"De novo design of protein interactions with learned surface fingerprints\", Nature, 617, 176-184", @@ -559320,82 +561421,82 @@ ], "subtitle":"Hdac6 znf domain inhibitor - darpin (designed ankyrin repeat protein) f10", "tags":[ - "darpin", "de novo protein", - "zinc finger" + "zinc finger", + "darpin" ], "keywords":[ - "responses", - "domain", + "designed", "analysis", + "impairs", + "responses", + "pocket", + "shows", + "dynamic", + "one", + "engages", "antiviral", - "early", + "repeat", + "moreover", + "influenza", + "ubiquitin", + "structures", + "downregulated", + "capsid", + "znf", + "iav", + "domain", + "sgs", "finger", + "effect", + "infection", + "darpin", + "via", + "zika", + "hdac6", "conditional", - "reversibly", - "one", + "generate", + "virus", "results", + "stress", + "target", + "prevents", + "validate", + "blocks", "proteins", - "virus", - "via", - "associated", - "pathway", - "generate", - "downregulated", - "catalytic", - "neurodegeneration", - "granules", - "attractive", + "vitro", + "binding", "drug", - "darpins", - "impairs", - "designed", - "moreover", - "discovery", - "zinc", + "subverts", + "formation", + "cellular", + "interaction", + "deacetylase", + "facilitates", "tandem", - "influenza", - "aggresomes", + "neurodegeneration", "ankyrin", - "darpin", - "uncoating", - "infection", - "promotes", - "prevents", - "vitro", - "zika", - "target", - "blocks", "domains", - "sgs", - "crystallographic", - "znf", - "expression", - "structures", - "dynamic", - "facilitates", + "cells", + "reversibly", + "pathway", "ub", - "effect", - "deacetylase", - "iav", - "validate", - "pathologies", - "cellular", - "repeat", - "capsid", - "stress", + "uncoating", "recruiting", - "engages", - "hdac6", - "formation", - "shows", - "ubiquitin", - "cells", - "subverts", - "pocket", - "binding", + "early", + "expression", + "catalytic", + "granules", + "discovery", + "pathologies", + "attractive", + "associated", + "crystallographic", "facilitate", - "interaction" + "darpins", + "aggresomes", + "zinc", + "promotes" ], "release_date":"2022-06-01", "publication":"\"Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways\", Cell Rep, 39, 110736-110736", @@ -559472,19 +561573,19 @@ }, { "sim":267.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":267.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":267.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":267.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":267.0, @@ -559492,35 +561593,35 @@ }, { "sim":267.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":267.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":267.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":267.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":267.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":267.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":267.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":267.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":266.0, @@ -559536,11 +561637,11 @@ }, { "sim":262.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":262.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":262.0, @@ -559560,11 +561661,11 @@ }, { "sim":256.0, - "partner":"5oos" + "partner":"5op3" }, { "sim":256.0, - "partner":"5op3" + "partner":"5oos" }, { "sim":256.0, @@ -559572,11 +561673,11 @@ }, { "sim":256.0, - "partner":"7dnf" + "partner":"5knh" }, { "sim":256.0, - "partner":"5knh" + "partner":"7dnf" }, { "sim":256.0, @@ -559660,7 +561761,7 @@ }, { "sim":231.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":231.0, @@ -559668,15 +561769,15 @@ }, { "sim":231.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":230.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":230.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":230.0, @@ -559708,11 +561809,11 @@ }, { "sim":215.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":215.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":209.0, @@ -559724,11 +561825,11 @@ }, { "sim":207.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":207.0, - "partner":"4qfv" + "partner":"4o60" }, { "sim":204.0, @@ -559750,6 +561851,10 @@ "sim":192.0, "partner":"9f24" }, + { + "sim":187.0, + "partner":"9glq" + }, { "sim":187.0, "partner":"4hqd" @@ -559818,11 +561923,11 @@ }, { "sim":277.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":277.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":277.0, @@ -559890,7 +561995,7 @@ }, { "sim":267.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":267.0, @@ -559898,11 +562003,11 @@ }, { "sim":267.0, - "partner":"6mze" + "partner":"7z02" }, { "sim":267.0, - "partner":"7z02" + "partner":"7ac5" }, { "sim":267.0, @@ -559910,11 +562015,11 @@ }, { "sim":267.0, - "partner":"7ac5" + "partner":"4lnu" }, { "sim":267.0, - "partner":"4lnu" + "partner":"6zwb" }, { "sim":267.0, @@ -559930,11 +562035,11 @@ }, { "sim":267.0, - "partner":"6zwb" + "partner":"6zwc" }, { "sim":267.0, - "partner":"6zwc" + "partner":"7z01" }, { "sim":265.0, @@ -559974,11 +562079,11 @@ }, { "sim":262.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":262.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":262.0, @@ -560014,11 +562119,11 @@ }, { "sim":258.0, - "partner":"5oyj" + "partner":"2bkk" }, { "sim":258.0, - "partner":"2bkk" + "partner":"5oyj" }, { "sim":258.0, @@ -560036,45 +562141,25 @@ "sim":257.0, "partner":"6d65" }, - { - "sim":256.0, - "partner":"5eno" - }, - { - "sim":256.0, - "partner":"6zob" - }, - { - "sim":256.0, - "partner":"6zo5" - }, { "sim":256.0, "partner":"4dx6" }, { "sim":256.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":256.0, "partner":"6zoc" }, - { - "sim":256.0, - "partner":"5enp" - }, - { - "sim":256.0, - "partner":"6sgs" - }, { "sim":256.0, "partner":"6zo6" }, { "sim":256.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":256.0, @@ -560082,7 +562167,7 @@ }, { "sim":256.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":256.0, @@ -560090,11 +562175,11 @@ }, { "sim":256.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":256.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":256.0, @@ -560104,6 +562189,10 @@ "sim":256.0, "partner":"6zoe" }, + { + "sim":256.0, + "partner":"5enq" + }, { "sim":256.0, "partner":"6q4p" @@ -560114,19 +562203,19 @@ }, { "sim":256.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":256.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":256.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":256.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":256.0, @@ -560138,23 +562227,23 @@ }, { "sim":256.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":256.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":256.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":256.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":256.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":256.0, @@ -560170,15 +562259,15 @@ }, { "sim":256.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":256.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":256.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":256.0, @@ -560186,15 +562275,19 @@ }, { "sim":256.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":256.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":256.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":256.0, + "partner":"6sgr" }, { "sim":256.0, @@ -560210,12 +562303,24 @@ }, { "sim":256.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":256.0, "partner":"4dx5" }, + { + "sim":256.0, + "partner":"5eno" + }, + { + "sim":256.0, + "partner":"6zo5" + }, + { + "sim":256.0, + "partner":"6q4n" + }, { "sim":256.0, "partner":"5mlb" @@ -560378,11 +562483,11 @@ }, { "sim":236.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":236.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":233.0, @@ -560418,11 +562523,11 @@ }, { "sim":218.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":218.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":217.0, @@ -560436,10 +562541,6 @@ "sim":214.0, "partner":"5itz" }, - { - "sim":214.0, - "partner":"7pd8" - }, { "sim":214.0, "partner":"7pdd" @@ -560452,6 +562553,10 @@ "sim":214.0, "partner":"7pdh" }, + { + "sim":214.0, + "partner":"7pd8" + }, { "sim":207.0, "partner":"6mzg" @@ -560636,10 +562741,6 @@ "sim":115.0, "partner":"5y4f" }, - { - "sim":113.0, - "partner":"5vhj" - }, { "sim":113.0, "partner":"5vhh" @@ -560670,16 +562771,20 @@ }, { "sim":113.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":113.0, - "partner":"1uoh" + "partner":"5vhp" }, { "sim":113.0, "partner":"7vo6" }, + { + "sim":113.0, + "partner":"1uoh" + }, { "sim":113.0, "partner":"5vhi" @@ -560702,15 +562807,15 @@ }, { "sim":112.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":112.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":112.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":111.0, @@ -560762,11 +562867,11 @@ }, { "sim":102.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":102.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":100.0, @@ -560854,11 +562959,11 @@ }, { "sim":92.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":92.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":92.0, @@ -561078,11 +563183,11 @@ }, { "sim":82.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":82.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":81.0, @@ -561096,14 +563201,6 @@ "sim":81.0, "partner":"2kxp" }, - { - "sim":81.0, - "partner":"3aaa" - }, - { - "sim":81.0, - "partner":"7dsb" - }, { "sim":81.0, "partner":"7df7" @@ -561114,11 +563211,11 @@ }, { "sim":81.0, - "partner":"6m11" + "partner":"7dsb" }, { "sim":81.0, - "partner":"6m12" + "partner":"3aaa" }, { "sim":81.0, @@ -561145,12 +563242,16 @@ "partner":"4o1p" }, { - "sim":80.0, - "partner":"6aun" + "sim":81.0, + "partner":"6m11" + }, + { + "sim":81.0, + "partner":"6m12" }, { "sim":80.0, - "partner":"6v9x" + "partner":"6aun" }, { "sim":80.0, @@ -561164,6 +563265,10 @@ "sim":80.0, "partner":"6v9w" }, + { + "sim":80.0, + "partner":"6v9x" + }, { "sim":80.0, "partner":"6pqo" @@ -561266,15 +563371,15 @@ }, { "sim":69.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":69.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":69.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":69.0, @@ -561296,10 +563401,6 @@ "sim":68.0, "partner":"5wo6" }, - { - "sim":68.0, - "partner":"5iwr" - }, { "sim":68.0, "partner":"5iwt" @@ -561354,11 +563455,11 @@ }, { "sim":68.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":68.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":68.0, @@ -561398,7 +563499,7 @@ }, { "sim":68.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":68.0, @@ -561432,6 +563533,10 @@ "sim":68.0, "partner":"7t6l" }, + { + "sim":68.0, + "partner":"7t6m" + }, { "sim":67.0, "partner":"6tmd" @@ -561516,10 +563621,6 @@ "sim":62.0, "partner":"6mca" }, - { - "sim":61.0, - "partner":"7k4a" - }, { "sim":61.0, "partner":"7k4b" @@ -561542,7 +563643,7 @@ }, { "sim":61.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":61.0, @@ -561558,11 +563659,11 @@ }, { "sim":61.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":61.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":61.0, @@ -561580,6 +563681,10 @@ "sim":61.0, "partner":"6bo8" }, + { + "sim":61.0, + "partner":"6bo9" + }, { "sim":57.0, "partner":"6sku" @@ -561934,81 +564039,81 @@ "de novo protein" ], "keywords":[ - "diverse", - "fluorimetric", - "displacement", - "drink", - "many", - "causes", - "channels", - "differential", - "chemistries", - "models", + "designed", "diagnostically", + "complex", + "alternative", + "central", + "mammalian", + "models", + "taste", + "coupled", + "challenging", + "fingerprints", + "many", + "drink", + "displacement", "receptors", - "use", - "patterns", - "hundreds", - "barrels", + "show", + "smell", + "diverse", + "accommodate", + "used", "de", - "novo", - "analytes", - "relate", - "sizes", - "identify", - "place", - "peptides", - "designed", - "senses", + "discriminates", + "computationally", "\u03b1hbs", - "challenging", + "attempts", + "altered", + "mixtures", + "biological", + "differential", + "potential", + "sizes", + "sense", + "fluorimetric", + "synthetic", + "mimic", + "causes", "samples", + "provide", + "dyes", "resulting", - "small", - "employ", - "used", - "taste", + "relate", + "place", + "various", "relevant", - "shapes", - "provide", - "robust", + "analytes", "vary", - "biomolecules", - "smell", - "system", - "fluorophore", - "sensors", - "potential", - "central", + "patterns", "chemically", - "show", + "binding", + "biomolecules", + "train", + "molecules", + "use", + "identify", "sensing", - "sense", - "mimic", - "altered", - "synthetic", "arrays", - "mammalian", - "attempts", - "dyes", - "complex", - "fluoresce", + "senses", + "novo", + "shapes", "upon", - "train", + "hundreds", "settings", - "mixtures", - "fingerprints", - "various", - "biological", - "computationally", - "discriminates", - "accommodate", - "coupled", - "molecules", - "alternative", - "binding", + "system", + "small", + "channels", + "fluoresce", + "peptides", + "sensors", + "fluorophore", "predictably", - "range" + "range", + "employ", + "chemistries", + "robust", + "barrels" ], "release_date":"2022-06-15", "publication":"\"Differential sensing with arrays of de novo designed peptide assemblies\", Nat Commun, 14, 383-383", @@ -562327,71 +564432,71 @@ "subtitle":"Structure of a leucinostatin derivative determined by host lattice display : l1e4v1 construct", "tags":[ "host lattice display", - "engbf", "leucinostatin", + "darpin", "de novo protein", - "darpin" + "engbf" ], "keywords":[ - "diverse", - "library", - "analysis", - "might", + "designed", + "complex", "complicates", + "conformation", + "analysis", + "flexibility", + "ribosome", + "diffraction", + "organic", "many", - "zhawoc6027", + "hydrophobic", + "structural", + "biotinylated", + "diverse", + "derivative", + "structures", + "functionally", + "almost", + "previously", + "display", + "leucinostatin", + "selected", + "darpin", + "distorted", + "structure", + "important", + "might", + "host", + "determined", + "library", + "solvents", + "means", "amino", - "buffer", "proteins", - "recognizing", + "comprising", + "zhawoc6027", "conditions", - "aqueous", + "lattice", + "compounds", + "insoluble", + "adopts", + "applied", + "technology", "reveals", - "developed", - "host", - "ribosome", - "almost", - "darpins", - "means", "peptides", "acids", - "designed", - "immobilized", - "lattice", - "darpin", + "buffer", "physiological", - "flexibility", "two", - "insoluble", - "determined", - "organic", - "leucinostatin", - "comparison", - "technology", - "structures", - "solvents", - "conformation", - "termini", - "hydrophobic", - "complex", - "diffraction", - "adopts", - "structure", + "developed", + "recognizing", "elevated", - "derivative", - "display", - "compounds", - "biotinylated", - "applied", - "comprising", - "important", - "functionally", - "structural", "related", - "selected", - "distorted", - "previously", - "investigate" + "immobilized", + "termini", + "aqueous", + "darpins", + "investigate", + "comparison" ], "release_date":"2022-12-07", "publication":"\"Structure of a hydrophobic leucinostatin derivative determined by host lattice display\", Acta Crystallogr D Struct Biol, 78, 1439-1450", @@ -562448,11 +564553,11 @@ }, { "sim":261.0, - "partner":"7zyu" + "partner":"7z7c" }, { "sim":261.0, - "partner":"7z7c" + "partner":"7zyu" }, { "sim":259.0, @@ -562468,11 +564573,11 @@ }, { "sim":253.0, - "partner":"7z72" + "partner":"7z71" }, { "sim":253.0, - "partner":"7z71" + "partner":"7z72" }, { "sim":253.0, @@ -562520,47 +564625,47 @@ }, { "sim":241.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":241.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":241.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":241.0, - "partner":"4j7w" + "partner":"8qla" }, { "sim":241.0, - "partner":"4dui" + "partner":"8ql8" }, { "sim":241.0, - "partner":"8ql9" + "partner":"4dui" }, { "sim":241.0, - "partner":"8ql8" + "partner":"8qea" }, { "sim":241.0, - "partner":"8ql3" + "partner":"8qlb" }, { "sim":241.0, - "partner":"9f8g" + "partner":"8ql9" }, { "sim":241.0, - "partner":"8ql6" + "partner":"8ql7" }, { "sim":241.0, - "partner":"8ql5" + "partner":"4j7w" }, { "sim":241.0, @@ -562568,15 +564673,15 @@ }, { "sim":241.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":241.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":241.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":238.0, @@ -562632,7 +564737,7 @@ }, { "sim":222.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":222.0, @@ -562640,7 +564745,7 @@ }, { "sim":222.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":221.0, @@ -562672,11 +564777,11 @@ }, { "sim":218.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":218.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":218.0, @@ -562720,11 +564825,11 @@ }, { "sim":194.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":194.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":192.0, @@ -562734,6 +564839,10 @@ "sim":186.0, "partner":"8ak1" }, + { + "sim":182.0, + "partner":"9glq" + }, { "sim":181.0, "partner":"9f23" @@ -562882,11 +564991,11 @@ }, { "sim":250.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":250.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":249.0, @@ -562944,25 +565053,13 @@ "sim":244.0, "partner":"6moe" }, - { - "sim":243.0, - "partner":"5eno" - }, - { - "sim":243.0, - "partner":"6zob" - }, - { - "sim":243.0, - "partner":"6zo5" - }, { "sim":243.0, "partner":"4dx6" }, { "sim":243.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":243.0, @@ -562970,35 +565067,35 @@ }, { "sim":243.0, - "partner":"5enp" + "partner":"6zo6" }, { "sim":243.0, - "partner":"6sgs" + "partner":"5enp" }, { "sim":243.0, - "partner":"6zo6" + "partner":"6q4o" }, { "sim":243.0, - "partner":"4dx7" + "partner":"7b8r" }, { "sim":243.0, - "partner":"6q4o" + "partner":"6zod" }, { "sim":243.0, - "partner":"4u95" + "partner":"4dx7" }, { "sim":243.0, - "partner":"6zod" + "partner":"4u95" }, { "sim":243.0, - "partner":"7b8r" + "partner":"6zo7" }, { "sim":243.0, @@ -563006,23 +565103,23 @@ }, { "sim":243.0, - "partner":"5enq" + "partner":"6zoe" }, { "sim":243.0, - "partner":"6zo7" + "partner":"5enq" }, { "sim":243.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":243.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":243.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":243.0, @@ -563036,10 +565133,6 @@ "sim":243.0, "partner":"4u96" }, - { - "sim":243.0, - "partner":"7b8s" - }, { "sim":243.0, "partner":"6zo8" @@ -563050,23 +565143,23 @@ }, { "sim":243.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":243.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":243.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":243.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":243.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":243.0, @@ -563078,15 +565171,15 @@ }, { "sim":243.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":243.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":243.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":243.0, @@ -563094,15 +565187,19 @@ }, { "sim":243.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":243.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":243.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":243.0, + "partner":"6sgr" }, { "sim":243.0, @@ -563118,12 +565215,24 @@ }, { "sim":243.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":243.0, "partner":"4dx5" }, + { + "sim":243.0, + "partner":"5eno" + }, + { + "sim":243.0, + "partner":"6zo5" + }, + { + "sim":243.0, + "partner":"6q4n" + }, { "sim":243.0, "partner":"5lel" @@ -563166,7 +565275,7 @@ }, { "sim":241.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":241.0, @@ -563174,11 +565283,11 @@ }, { "sim":241.0, - "partner":"6mze" + "partner":"7z02" }, { "sim":241.0, - "partner":"7z02" + "partner":"7ac5" }, { "sim":241.0, @@ -563186,11 +565295,11 @@ }, { "sim":241.0, - "partner":"7ac5" + "partner":"4lnu" }, { "sim":241.0, - "partner":"4lnu" + "partner":"6zwb" }, { "sim":241.0, @@ -563206,19 +565315,19 @@ }, { "sim":241.0, - "partner":"6zwb" + "partner":"6zwc" }, { "sim":241.0, - "partner":"6zwc" + "partner":"7z01" }, { "sim":240.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":240.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":240.0, @@ -563258,11 +565367,11 @@ }, { "sim":238.0, - "partner":"5oyj" + "partner":"2p2c" }, { "sim":238.0, - "partner":"2p2c" + "partner":"5oyj" }, { "sim":238.0, @@ -563454,11 +565563,11 @@ }, { "sim":215.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":215.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":215.0, @@ -563466,11 +565575,11 @@ }, { "sim":213.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":213.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":209.0, @@ -563480,10 +565589,6 @@ "sim":204.0, "partner":"6moj" }, - { - "sim":202.0, - "partner":"7pd8" - }, { "sim":202.0, "partner":"7pdd" @@ -563496,6 +565601,10 @@ "sim":202.0, "partner":"7pdh" }, + { + "sim":202.0, + "partner":"7pd8" + }, { "sim":198.0, "partner":"5aq7" @@ -563538,19 +565647,19 @@ }, { "sim":173.0, - "partner":"6d66" + "partner":"2xzt" }, { "sim":173.0, - "partner":"6d67" + "partner":"2v4h" }, { "sim":173.0, - "partner":"2xzt" + "partner":"6d66" }, { "sim":173.0, - "partner":"2v4h" + "partner":"6d67" }, { "sim":173.0, @@ -563638,23 +565747,23 @@ }, { "sim":117.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":117.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":117.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":117.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":117.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":117.0, @@ -563662,11 +565771,11 @@ }, { "sim":117.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":117.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":117.0, @@ -563704,10 +565813,6 @@ "sim":113.0, "partner":"3utm" }, - { - "sim":111.0, - "partner":"3aji" - }, { "sim":111.0, "partner":"2dvw" @@ -563718,11 +565823,11 @@ }, { "sim":111.0, - "partner":"6urq" + "partner":"3aji" }, { - "sim":109.0, - "partner":"5vhj" + "sim":111.0, + "partner":"6urq" }, { "sim":109.0, @@ -563754,15 +565859,15 @@ }, { "sim":109.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":109.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":109.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":109.0, @@ -563772,6 +565877,10 @@ "sim":109.0, "partner":"7vxw" }, + { + "sim":109.0, + "partner":"1uoh" + }, { "sim":109.0, "partner":"7vy4" @@ -563782,11 +565891,11 @@ }, { "sim":109.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":109.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":109.0, @@ -563842,11 +565951,11 @@ }, { "sim":98.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":98.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":98.0, @@ -563882,11 +565991,11 @@ }, { "sim":96.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":96.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":96.0, @@ -564040,10 +566149,6 @@ "sim":81.0, "partner":"6e2g" }, - { - "sim":80.0, - "partner":"6v9x" - }, { "sim":80.0, "partner":"6v9y" @@ -564056,6 +566161,10 @@ "sim":80.0, "partner":"6v9w" }, + { + "sim":80.0, + "partner":"6v9x" + }, { "sim":80.0, "partner":"7or0" @@ -564088,10 +566197,6 @@ "sim":78.0, "partner":"5wo6" }, - { - "sim":78.0, - "partner":"5iwr" - }, { "sim":78.0, "partner":"5iwt" @@ -564144,6 +566249,10 @@ "sim":78.0, "partner":"5iwp" }, + { + "sim":78.0, + "partner":"5iwr" + }, { "sim":78.0, "partner":"5wo7" @@ -564194,23 +566303,19 @@ }, { "sim":76.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":76.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":76.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":76.0, - "partner":"7dsa" - }, - { - "sim":75.0, - "partner":"6o1p" + "partner":"3aaa" }, { "sim":75.0, @@ -564250,7 +566355,7 @@ }, { "sim":75.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":75.0, @@ -564284,6 +566389,10 @@ "sim":75.0, "partner":"7t6l" }, + { + "sim":75.0, + "partner":"7t6m" + }, { "sim":74.0, "partner":"1myo" @@ -564296,14 +566405,6 @@ "sim":74.0, "partner":"2kxp" }, - { - "sim":74.0, - "partner":"6m11" - }, - { - "sim":74.0, - "partner":"6m12" - }, { "sim":74.0, "partner":"6m13" @@ -564328,6 +566429,14 @@ "sim":74.0, "partner":"4o1p" }, + { + "sim":74.0, + "partner":"6m11" + }, + { + "sim":74.0, + "partner":"6m12" + }, { "sim":73.0, "partner":"1d9s" @@ -564362,15 +566471,15 @@ }, { "sim":70.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":70.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":70.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":70.0, @@ -564384,10 +566493,6 @@ "sim":70.0, "partner":"4ot9" }, - { - "sim":70.0, - "partner":"7k4a" - }, { "sim":70.0, "partner":"7k4b" @@ -564410,7 +566515,7 @@ }, { "sim":70.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":70.0, @@ -564426,11 +566531,11 @@ }, { "sim":70.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":70.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":70.0, @@ -564448,6 +566553,10 @@ "sim":70.0, "partner":"6bo8" }, + { + "sim":70.0, + "partner":"6bo9" + }, { "sim":69.0, "partner":"1oy3" @@ -564548,21 +566657,17 @@ "sim":51.0, "partner":"1dcq" }, - { - "sim":51.0, - "partner":"7ttr" - }, { "sim":51.0, "partner":"7tts" }, { "sim":51.0, - "partner":"6lgp" + "partner":"7ttr" }, { "sim":51.0, - "partner":"6dvz" + "partner":"6lgp" }, { "sim":51.0, @@ -564574,19 +566679,11 @@ }, { "sim":51.0, - "partner":"6pvo" - }, - { - "sim":51.0, - "partner":"7mij" - }, - { - "sim":51.0, - "partner":"6pvp" + "partner":"6dvz" }, { "sim":51.0, - "partner":"7ras" + "partner":"6pvq" }, { "sim":51.0, @@ -564594,7 +566691,7 @@ }, { "sim":51.0, - "partner":"6pvq" + "partner":"7ras" }, { "sim":51.0, @@ -564608,13 +566705,17 @@ "sim":51.0, "partner":"7mim" }, + { + "sim":51.0, + "partner":"6pvl" + }, { "sim":51.0, "partner":"7min" }, { "sim":51.0, - "partner":"6pvl" + "partner":"6pvm" }, { "sim":51.0, @@ -564626,11 +566727,19 @@ }, { "sim":51.0, - "partner":"6pvm" + "partner":"6pvn" }, { "sim":51.0, - "partner":"6pvn" + "partner":"6pvo" + }, + { + "sim":51.0, + "partner":"6pvp" + }, + { + "sim":51.0, + "partner":"7mij" } ], "struct_thr_sim_designed":[ @@ -564746,71 +566855,71 @@ "subtitle":"Structure of a leucinostatin derivative determined by host lattice display : l1f11v1 construct", "tags":[ "host lattice display", - "engbf", "leucinostatin", + "darpin", "de novo protein", - "darpin" + "engbf" ], "keywords":[ - "diverse", - "library", - "analysis", - "might", + "designed", + "complex", "complicates", + "conformation", + "analysis", + "flexibility", + "ribosome", + "diffraction", + "organic", "many", - "zhawoc6027", + "hydrophobic", + "structural", + "biotinylated", + "diverse", + "derivative", + "structures", + "functionally", + "almost", + "previously", + "display", + "leucinostatin", + "selected", + "darpin", + "distorted", + "structure", + "important", + "might", + "host", + "determined", + "library", + "solvents", + "means", "amino", - "buffer", "proteins", - "recognizing", + "comprising", + "zhawoc6027", "conditions", - "aqueous", + "lattice", + "compounds", + "insoluble", + "adopts", + "applied", + "technology", "reveals", - "developed", - "host", - "ribosome", - "almost", - "darpins", - "means", "peptides", "acids", - "designed", - "immobilized", - "lattice", - "darpin", + "buffer", "physiological", - "flexibility", "two", - "insoluble", - "determined", - "organic", - "leucinostatin", - "comparison", - "technology", - "structures", - "solvents", - "conformation", - "termini", - "hydrophobic", - "complex", - "diffraction", - "adopts", - "structure", + "developed", + "recognizing", "elevated", - "derivative", - "display", - "compounds", - "biotinylated", - "applied", - "comprising", - "important", - "functionally", - "structural", "related", - "selected", - "distorted", - "previously", - "investigate" + "immobilized", + "termini", + "aqueous", + "darpins", + "investigate", + "comparison" ], "release_date":"2022-12-07", "publication":"\"Structure of a hydrophobic leucinostatin derivative determined by host lattice display\", Acta Crystallogr D Struct Biol, 78, 1439-1450", @@ -564883,11 +566992,11 @@ }, { "sim":254.0, - "partner":"7z72" + "partner":"7z71" }, { "sim":254.0, - "partner":"7z71" + "partner":"7z72" }, { "sim":253.0, @@ -564915,19 +567024,19 @@ }, { "sim":250.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":250.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":250.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":250.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":250.0, @@ -564935,35 +567044,35 @@ }, { "sim":250.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":250.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":250.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":250.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":250.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":250.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":250.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":250.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":250.0, @@ -565023,11 +567132,11 @@ }, { "sim":241.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":241.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":241.0, @@ -565035,11 +567144,11 @@ }, { "sim":241.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":241.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":241.0, @@ -565075,7 +567184,7 @@ }, { "sim":237.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":237.0, @@ -565083,7 +567192,7 @@ }, { "sim":237.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":236.0, @@ -565127,11 +567236,11 @@ }, { "sim":201.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":201.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":201.0, @@ -565153,6 +567262,10 @@ "sim":190.0, "partner":"8ak1" }, + { + "sim":186.0, + "partner":"9glq" + }, { "sim":185.0, "partner":"8aiw" @@ -565289,11 +567402,11 @@ }, { "sim":262.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":262.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":262.0, @@ -565389,7 +567502,7 @@ }, { "sim":250.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":250.0, @@ -565397,11 +567510,11 @@ }, { "sim":250.0, - "partner":"6mze" + "partner":"7z02" }, { "sim":250.0, - "partner":"7z02" + "partner":"7ac5" }, { "sim":250.0, @@ -565409,11 +567522,11 @@ }, { "sim":250.0, - "partner":"7ac5" + "partner":"4lnu" }, { "sim":250.0, - "partner":"4lnu" + "partner":"6zwb" }, { "sim":250.0, @@ -565429,11 +567542,11 @@ }, { "sim":250.0, - "partner":"6zwb" + "partner":"6zwc" }, { "sim":250.0, - "partner":"6zwc" + "partner":"7z01" }, { "sim":250.0, @@ -565485,11 +567598,11 @@ }, { "sim":248.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":248.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":248.0, @@ -565499,45 +567612,25 @@ "sim":248.0, "partner":"7odn" }, - { - "sim":247.0, - "partner":"5eno" - }, - { - "sim":247.0, - "partner":"6zob" - }, - { - "sim":247.0, - "partner":"6zo5" - }, { "sim":247.0, "partner":"4dx6" }, { "sim":247.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":247.0, "partner":"6zoc" }, - { - "sim":247.0, - "partner":"5enp" - }, - { - "sim":247.0, - "partner":"6sgs" - }, { "sim":247.0, "partner":"6zo6" }, { "sim":247.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":247.0, @@ -565545,7 +567638,7 @@ }, { "sim":247.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":247.0, @@ -565553,11 +567646,11 @@ }, { "sim":247.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":247.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":247.0, @@ -565567,6 +567660,10 @@ "sim":247.0, "partner":"6zoe" }, + { + "sim":247.0, + "partner":"5enq" + }, { "sim":247.0, "partner":"6q4p" @@ -565577,19 +567674,19 @@ }, { "sim":247.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":247.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":247.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":247.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":247.0, @@ -565601,23 +567698,23 @@ }, { "sim":247.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":247.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":247.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":247.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":247.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":247.0, @@ -565629,15 +567726,15 @@ }, { "sim":247.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":247.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":247.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":247.0, @@ -565645,15 +567742,19 @@ }, { "sim":247.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":247.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":247.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":247.0, + "partner":"6sgr" }, { "sim":247.0, @@ -565669,12 +567770,24 @@ }, { "sim":247.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":247.0, "partner":"4dx5" }, + { + "sim":247.0, + "partner":"5eno" + }, + { + "sim":247.0, + "partner":"6zo5" + }, + { + "sim":247.0, + "partner":"6q4n" + }, { "sim":247.0, "partner":"7mxi" @@ -565837,11 +567950,11 @@ }, { "sim":230.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":230.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":230.0, @@ -565893,20 +568006,16 @@ }, { "sim":207.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":207.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":203.0, "partner":"5itz" }, - { - "sim":203.0, - "partner":"7pd8" - }, { "sim":203.0, "partner":"7pdd" @@ -565919,6 +568028,10 @@ "sim":203.0, "partner":"7pdh" }, + { + "sim":203.0, + "partner":"7pd8" + }, { "sim":202.0, "partner":"6mzg" @@ -566077,23 +568190,23 @@ }, { "sim":118.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":118.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":118.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":118.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":118.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":118.0, @@ -566101,11 +568214,11 @@ }, { "sim":118.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":118.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":118.0, @@ -566147,10 +568260,6 @@ "sim":110.0, "partner":"5y4f" }, - { - "sim":108.0, - "partner":"3aji" - }, { "sim":108.0, "partner":"2dvw" @@ -566161,11 +568270,11 @@ }, { "sim":108.0, - "partner":"6by9" + "partner":"3aji" }, { - "sim":107.0, - "partner":"5vhj" + "sim":108.0, + "partner":"6by9" }, { "sim":107.0, @@ -566197,15 +568306,15 @@ }, { "sim":107.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":107.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":107.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":107.0, @@ -566215,6 +568324,10 @@ "sim":107.0, "partner":"7vxw" }, + { + "sim":107.0, + "partner":"1uoh" + }, { "sim":107.0, "partner":"7vy4" @@ -566225,11 +568338,11 @@ }, { "sim":107.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":107.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":107.0, @@ -566285,11 +568398,11 @@ }, { "sim":99.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":99.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":99.0, @@ -566301,11 +568414,11 @@ }, { "sim":97.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":97.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":97.0, @@ -566513,19 +568626,19 @@ }, { "sim":81.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":81.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":81.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":81.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":81.0, @@ -566651,10 +568764,6 @@ "sim":78.0, "partner":"6aun" }, - { - "sim":78.0, - "partner":"6v9x" - }, { "sim":78.0, "partner":"6v9y" @@ -566667,6 +568776,10 @@ "sim":78.0, "partner":"6v9w" }, + { + "sim":78.0, + "partner":"6v9x" + }, { "sim":78.0, "partner":"7or0" @@ -566721,11 +568834,11 @@ }, { "sim":75.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":75.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":74.0, @@ -566739,10 +568852,6 @@ "sim":74.0, "partner":"2rfa" }, - { - "sim":74.0, - "partner":"6o1p" - }, { "sim":74.0, "partner":"6b5v" @@ -566781,7 +568890,7 @@ }, { "sim":74.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":74.0, @@ -566815,6 +568924,10 @@ "sim":74.0, "partner":"7t6l" }, + { + "sim":74.0, + "partner":"7t6m" + }, { "sim":73.0, "partner":"5z2n" @@ -566831,10 +568944,6 @@ "sim":72.0, "partner":"5wo6" }, - { - "sim":72.0, - "partner":"5iwr" - }, { "sim":72.0, "partner":"5iwt" @@ -566889,15 +568998,11 @@ }, { "sim":72.0, - "partner":"5wo7" - }, - { - "sim":72.0, - "partner":"6m11" + "partner":"5iwr" }, { "sim":72.0, - "partner":"6m12" + "partner":"5wo7" }, { "sim":72.0, @@ -566923,6 +569028,14 @@ "sim":72.0, "partner":"4o1p" }, + { + "sim":72.0, + "partner":"6m11" + }, + { + "sim":72.0, + "partner":"6m12" + }, { "sim":70.0, "partner":"1d9s" @@ -566975,10 +569088,6 @@ "sim":64.0, "partner":"3t9k" }, - { - "sim":64.0, - "partner":"7k4a" - }, { "sim":64.0, "partner":"7k4b" @@ -567001,7 +569110,7 @@ }, { "sim":64.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":64.0, @@ -567017,11 +569126,11 @@ }, { "sim":64.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":64.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":64.0, @@ -567039,6 +569148,10 @@ "sim":64.0, "partner":"6bo8" }, + { + "sim":64.0, + "partner":"6bo9" + }, { "sim":63.0, "partner":"6ghm" @@ -567165,11 +569278,11 @@ }, { "sim":52.0, - "partner":"7ttr" + "partner":"7tts" }, { "sim":52.0, - "partner":"7tts" + "partner":"7ttr" } ], "struct_thr_sim_designed":[ @@ -567288,116 +569401,116 @@ ], "subtitle":"X-ray crystal structure of a de novo designed antiparallel coiled-coil homotetramer with 4 heptad repeats, apcc-tet*", "tags":[ + "coiled coil", "de novo protein design", - "4-helix bundle", "de novo protein", - "coiled coil", + "4-helix bundle", "peptide assembly" ], "keywords":[ - "amongst", + "finally", + "role", + "repeat", + "key", + "methods", "background", - "many", - "studied", - "heptad", "multiple", - "use", - "ile", + "heterotetramers", "route", - "scaffolds", - "prediction", - "determine", - "robust", - "methods", - "crystal", - "target", - "analyzing", - "features", - "next", - "deduce", - "synthetic", - "interactions", - "assembled", - "designing", "gln", - "structure", - "repeat", - "turn", - "e", - "implement", - "direct", - "aim", - "proteins", - "de", - "determining", - "finally", - "leu", - "used", + "residue", + "folding", + "assembled", + "protein", + "derive", + "clear", + "helical", + "next", "fully", - "step", - "production", - "relationships", - "structures", - "ultimately", + "stabilization", "charged", - "recombinant", - "solution", - "assembly", - "biology", - "form", - "first", - "role", + "novo", + "b", + "confirmed", + "implement", + "recent", + "crystal", "rules", + "g", + "aqueous", + "using", + "robust", + "terms", + "antiparallel", + "bundles", "homotetramer", - "signature", - "functional", + "step", + "recombinant", + "residues", + "studied", + "completely", + "approach", + "proteins", + "use", "chemical", - "common", - "coli", - "bundles", - "identify", - "challenging", + "features", + "e", + "leu", + "complementary", + "computational", + "ala", + "signature", + "set", + "heptad", + "direct", + "designing", "advances", - "g", - "clear", - "provides", "design", - "heterotetramers", - "helical", - "using", - "derive", - "recent", + "challenging", + "provides", + "used", + "biology", + "functional", + "abcdefg", + "analyzing", + "assembly", + "prediction", + "relationships", + "determining", + "ile", + "solution", + "coli", "sequence", + "common", + "peptides", + "determine", + "aim", "could", - "key", - "known", - "completely", - "abcdefg", - "stabilization", - "designs", - "despite", + "production", + "form", + "deduce", + "many", "one", - "aqueous", - "approach", - "novo", + "structures", + "de", "rational", + "amongst", "understand", - "peptides", - "confirmed", - "residues", - "terms", - "complementary", - "antiparallel", - "ala", - "set", - "b", - "protein", - "residue", - "understanding", - "computational", + "first", + "structure", + "synthetic", + "scaffolds", + "target", + "interactions", "starts", - "folding", - "biophysical" + "biophysical", + "understanding", + "known", + "identify", + "ultimately", + "turn", + "despite", + "designs" ], "release_date":"2022-10-05", "publication":"\"From peptides to proteins: coiled-coil tetramers to single-chain 4-helix bundles\", Chem Sci, 13, 11330-11340", @@ -567438,66 +569551,66 @@ "sim":0.9986000061, "partner":"8qab" }, - { - "sim":0.9728000164, - "partner":"8qac" - }, { "sim":1.0, - "partner":"6q5n" + "partner":"6q5s" }, { "sim":1.0, - "partner":"6q5s" + "partner":"8qaa" }, { "sim":1.0, - "partner":"3r48" + "partner":"6q5n" }, { - "sim":1.0, - "partner":"8qaa" + "sim":0.9728000164, + "partner":"8qac" }, { "sim":0.9952999949, "partner":"3r3k" }, { - "sim":0.996999979, - "partner":"3r46" + "sim":1.0, + "partner":"3r48" }, { - "sim":0.9894000292, - "partner":"4h8m" + "sim":0.996999979, + "partner":"6q5p" }, { "sim":0.9983999729, - "partner":"6q5j" + "partner":"6q5r" }, { "sim":0.996999979, - "partner":"6q5p" + "partner":"3r46" }, { "sim":0.9983999729, - "partner":"6q5r" + "partner":"6q5j" }, { - "sim":0.9731000066, - "partner":"6q5q" + "sim":0.9894000292, + "partner":"4h8m" }, { "sim":0.9983999729, "partner":"4h7r" }, { - "sim":0.9769999981, - "partner":"3r47" + "sim":0.9731000066, + "partner":"6q5q" }, { "sim":0.9731000066, "partner":"6q5o" }, + { + "sim":0.9769999981, + "partner":"3r47" + }, { "sim":0.9986000061, "partner":"4h8o" @@ -567510,10 +569623,6 @@ "sim":0.9527999759, "partner":"5eon" }, - { - "sim":0.9508000016, - "partner":"5vte" - }, { "sim":0.9987999797, "partner":"4h8g" @@ -567526,6 +569635,10 @@ "sim":0.9894999862, "partner":"3r4h" }, + { + "sim":0.9508000016, + "partner":"5vte" + }, { "sim":0.9725999832, "partner":"4dzl" @@ -567553,7 +569666,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"6q5n" + "partner":"8qaa" }, "struct_max_sim_natural":{ "sim":0.996999979, @@ -567627,116 +569740,116 @@ ], "subtitle":"X-ray crystal structure of a de novo designed antiparallel coiled-coil homotetramer with 3 heptad repeats, apcc-tet*3", "tags":[ + "coiled coil", "de novo protein design", - "4-helix bundle", "de novo protein", - "coiled coil", + "4-helix bundle", "peptide assembly" ], "keywords":[ - "amongst", + "finally", + "role", + "repeat", + "key", + "methods", "background", - "many", - "studied", - "heptad", "multiple", - "use", - "ile", + "heterotetramers", "route", - "scaffolds", - "prediction", - "determine", - "robust", - "methods", - "crystal", - "target", - "analyzing", - "features", - "next", - "deduce", - "synthetic", - "interactions", - "assembled", - "designing", "gln", - "structure", - "repeat", - "turn", - "e", - "implement", - "direct", - "aim", - "proteins", - "de", - "determining", - "finally", - "leu", - "used", + "residue", + "folding", + "assembled", + "protein", + "derive", + "clear", + "helical", + "next", "fully", - "step", - "production", - "relationships", - "structures", - "ultimately", + "stabilization", "charged", - "recombinant", - "solution", - "assembly", - "biology", - "form", - "first", - "role", + "novo", + "b", + "confirmed", + "implement", + "recent", + "crystal", "rules", + "g", + "aqueous", + "using", + "robust", + "terms", + "antiparallel", + "bundles", "homotetramer", - "signature", - "functional", + "step", + "recombinant", + "residues", + "studied", + "completely", + "approach", + "proteins", + "use", "chemical", - "common", - "coli", - "bundles", - "identify", - "challenging", + "features", + "e", + "leu", + "complementary", + "computational", + "ala", + "signature", + "set", + "heptad", + "direct", + "designing", "advances", - "g", - "clear", - "provides", "design", - "heterotetramers", - "helical", - "using", - "derive", - "recent", + "challenging", + "provides", + "used", + "biology", + "functional", + "abcdefg", + "analyzing", + "assembly", + "prediction", + "relationships", + "determining", + "ile", + "solution", + "coli", "sequence", + "common", + "peptides", + "determine", + "aim", "could", - "key", - "known", - "completely", - "abcdefg", - "stabilization", - "designs", - "despite", + "production", + "form", + "deduce", + "many", "one", - "aqueous", - "approach", - "novo", + "structures", + "de", "rational", + "amongst", "understand", - "peptides", - "confirmed", - "residues", - "terms", - "complementary", - "antiparallel", - "ala", - "set", - "b", - "protein", - "residue", - "understanding", - "computational", + "first", + "structure", + "synthetic", + "scaffolds", + "target", + "interactions", "starts", - "folding", - "biophysical" + "biophysical", + "understanding", + "known", + "identify", + "ultimately", + "turn", + "despite", + "designs" ], "release_date":"2022-10-05", "publication":"\"From peptides to proteins: coiled-coil tetramers to single-chain 4-helix bundles\", Chem Sci, 13, 11330-11340", @@ -567801,6 +569914,10 @@ "sim":0.969900012, "partner":"6q5r" }, + { + "sim":0.9696999788, + "partner":"4h8m" + }, { "sim":0.969900012, "partner":"6q5j" @@ -567814,17 +569931,13 @@ "partner":"3r46" }, { - "sim":0.9696999788, - "partner":"4h8m" + "sim":0.969900012, + "partner":"6q5o" }, { "sim":0.9700000286, "partner":"3r48" }, - { - "sim":0.969900012, - "partner":"6q5o" - }, { "sim":0.9700000286, "partner":"4h8o" @@ -567833,6 +569946,10 @@ "sim":0.969900012, "partner":"4h7r" }, + { + "sim":0.969900012, + "partner":"6q5q" + }, { "sim":0.9977999926, "partner":"6q5i" @@ -567841,10 +569958,6 @@ "sim":0.9981999993, "partner":"6q5m" }, - { - "sim":0.969900012, - "partner":"6q5q" - }, { "sim":0.969900012, "partner":"5eon" @@ -567853,14 +569966,14 @@ "sim":0.969900012, "partner":"5vte" }, - { - "sim":0.9944000244, - "partner":"6q5l" - }, { "sim":0.9681000113, "partner":"5eoj" }, + { + "sim":0.9944000244, + "partner":"6q5l" + }, { "sim":0.969900012, "partner":"4h8f" @@ -567962,116 +570075,116 @@ ], "subtitle":"X-ray crystal structure of a de novo designed antiparallel coiled-coil heterotetramer with 3 heptad repeats, apcc-tet*3-a2b2", "tags":[ + "coiled coil", "de novo protein design", - "4-helix bundle", "de novo protein", - "coiled coil", + "4-helix bundle", "peptide assembly" ], "keywords":[ - "amongst", + "finally", + "role", + "repeat", + "key", + "methods", "background", - "many", - "studied", - "heptad", "multiple", - "use", - "ile", + "heterotetramers", "route", - "scaffolds", - "prediction", - "determine", - "robust", - "methods", - "crystal", - "target", - "analyzing", - "features", - "next", - "deduce", - "synthetic", - "interactions", - "assembled", - "designing", "gln", - "structure", - "repeat", - "turn", - "e", - "implement", - "direct", - "aim", - "proteins", - "de", - "determining", - "finally", - "leu", - "used", + "residue", + "folding", + "assembled", + "protein", + "derive", + "clear", + "helical", + "next", "fully", - "step", - "production", - "relationships", - "structures", - "ultimately", + "stabilization", "charged", - "recombinant", - "solution", - "assembly", - "biology", - "form", - "first", - "role", + "novo", + "b", + "confirmed", + "implement", + "recent", + "crystal", "rules", + "g", + "aqueous", + "using", + "robust", + "terms", + "antiparallel", + "bundles", "homotetramer", - "signature", - "functional", + "step", + "recombinant", + "residues", + "studied", + "completely", + "approach", + "proteins", + "use", "chemical", - "common", - "coli", - "bundles", - "identify", - "challenging", + "features", + "e", + "leu", + "complementary", + "computational", + "ala", + "signature", + "set", + "heptad", + "direct", + "designing", "advances", - "g", - "clear", - "provides", "design", - "heterotetramers", - "helical", - "using", - "derive", - "recent", + "challenging", + "provides", + "used", + "biology", + "functional", + "abcdefg", + "analyzing", + "assembly", + "prediction", + "relationships", + "determining", + "ile", + "solution", + "coli", "sequence", + "common", + "peptides", + "determine", + "aim", "could", - "key", - "known", - "completely", - "abcdefg", - "stabilization", - "designs", - "despite", + "production", + "form", + "deduce", + "many", "one", - "aqueous", - "approach", - "novo", + "structures", + "de", "rational", + "amongst", "understand", - "peptides", - "confirmed", - "residues", - "terms", - "complementary", - "antiparallel", - "ala", - "set", - "b", - "protein", - "residue", - "understanding", - "computational", + "first", + "structure", + "synthetic", + "scaffolds", + "target", + "interactions", "starts", - "folding", - "biophysical" + "biophysical", + "understanding", + "known", + "identify", + "ultimately", + "turn", + "despite", + "designs" ], "release_date":"2022-10-05", "publication":"\"From peptides to proteins: coiled-coil tetramers to single-chain 4-helix bundles\", Chem Sci, 13, 11330-11340", @@ -568112,49 +570225,25 @@ "sim":1.0, "partner":"8a3i" }, - { - "sim":0.9667999744, - "partner":"8a09" - }, { "sim":0.9708999991, "partner":"8a3g" }, - { - "sim":0.9689999819, - "partner":"6q5n" - }, - { - "sim":0.9696999788, - "partner":"6q5o" - }, - { - "sim":0.9656000137, - "partner":"5eoj" - }, - { - "sim":0.9708999991, - "partner":"5eon" - }, { "sim":0.9696999788, - "partner":"6q5q" - }, - { - "sim":0.9646999836, - "partner":"5vte" + "partner":"3r48" }, { - "sim":0.9708999991, - "partner":"6xxz" + "sim":0.9689999819, + "partner":"6q5n" }, { "sim":0.9696999788, - "partner":"3r48" + "partner":"6q5r" }, { "sim":0.9696999788, - "partner":"6q5r" + "partner":"6q5q" }, { "sim":0.9696999788, @@ -568188,6 +570277,18 @@ "sim":0.9902999997, "partner":"6q5h" }, + { + "sim":0.9708999991, + "partner":"5eon" + }, + { + "sim":0.9646999836, + "partner":"5vte" + }, + { + "sim":0.9696999788, + "partner":"6q5o" + }, { "sim":0.9979000092, "partner":"6q5i" @@ -568204,6 +570305,18 @@ "sim":0.9825999737, "partner":"6q5l" }, + { + "sim":0.9667999744, + "partner":"8a09" + }, + { + "sim":0.9656000137, + "partner":"5eoj" + }, + { + "sim":0.9708999991, + "partner":"6xxz" + }, { "sim":0.9980999827, "partner":"4h8l" @@ -568314,114 +570427,114 @@ "subtitle":"X-ray crystal structure of a de novo designed single-chain antiparallel 4-helix coiled-coil bundle, sc-apcc-4", "tags":[ "de novo protein design", - "4-helix bundle", "de novo protein", - "coiled coil" + "coiled coil", + "4-helix bundle" ], "keywords":[ - "amongst", + "finally", + "role", + "repeat", + "key", + "methods", "background", - "many", - "studied", - "heptad", "multiple", - "use", - "ile", + "heterotetramers", "route", - "scaffolds", - "prediction", - "determine", - "robust", - "methods", - "crystal", - "target", - "analyzing", - "features", - "next", - "deduce", - "synthetic", - "interactions", - "assembled", - "designing", "gln", - "structure", - "repeat", - "turn", - "e", - "implement", - "direct", - "aim", - "proteins", - "de", - "determining", - "finally", - "leu", - "used", + "residue", + "folding", + "assembled", + "protein", + "derive", + "clear", + "helical", + "next", "fully", - "step", - "production", - "relationships", - "structures", - "ultimately", + "stabilization", "charged", - "recombinant", - "solution", - "assembly", - "biology", - "form", - "first", - "role", + "novo", + "b", + "confirmed", + "implement", + "recent", + "crystal", "rules", + "g", + "aqueous", + "using", + "robust", + "terms", + "antiparallel", + "bundles", "homotetramer", - "signature", - "functional", + "step", + "recombinant", + "residues", + "studied", + "completely", + "approach", + "proteins", + "use", "chemical", - "common", - "coli", - "bundles", - "identify", - "challenging", + "features", + "e", + "leu", + "complementary", + "computational", + "ala", + "signature", + "set", + "heptad", + "direct", + "designing", "advances", - "g", - "clear", - "provides", "design", - "heterotetramers", - "helical", - "using", - "derive", - "recent", + "challenging", + "provides", + "used", + "biology", + "functional", + "abcdefg", + "analyzing", + "assembly", + "prediction", + "relationships", + "determining", + "ile", + "solution", + "coli", "sequence", + "common", + "peptides", + "determine", + "aim", "could", - "key", - "known", - "completely", - "abcdefg", - "stabilization", - "designs", - "despite", + "production", + "form", + "deduce", + "many", "one", - "aqueous", - "approach", - "novo", + "structures", + "de", "rational", + "amongst", "understand", - "peptides", - "confirmed", - "residues", - "terms", - "complementary", - "antiparallel", - "ala", - "set", - "b", - "protein", - "residue", - "understanding", - "computational", + "first", + "structure", + "synthetic", + "scaffolds", + "target", + "interactions", "starts", - "folding", - "biophysical" + "biophysical", + "understanding", + "known", + "identify", + "ultimately", + "turn", + "despite", + "designs" ], "release_date":"2022-10-05", "publication":"\"From peptides to proteins: coiled-coil tetramers to single-chain 4-helix bundles\", Chem Sci, 13, 11330-11340", @@ -568571,80 +570684,80 @@ "recombination" ], "keywords":[ - "sites", + "breaks", + "complex", + "repair", + "producing", + "homologous", + "octameric", + "timely", + "reduction", + "dsbs", + "egg", + "meiotic", + "hr", + "able", + "structures", + "disruptive", + "xenopus", + "absence", + "previously", + "dna", "hsf2bp", - "control", - "causes", - "dmc1", "trigger", - "large", + "brca2", + "severe", + "effect", + "interstrand", + "hsf2bpbrca2", + "causes", + "addition", + "report", + "leads", + "loading", "rad51", + "also", + "thus", "ring", - "interlock", + "dmc1", + "somatic", + "damage", "brme1", - "dna", + "control", + "propose", + "prevents", "cell", - "damage", - "somatic", - "report", - "also", - "hr", - "repair", - "hsf2bpbrca2", + "recombinases", "oligomerization", - "promoting", - "xenopus", - "octameric", - "rings", - "meiotic", - "interacts", - "homologous", - "extracts", - "concentrates", - "loading", - "ensures", "turnover", - "producing", - "absence", - "recombinase", - "prevents", - "timely", - "brca2", - "recombinases", - "ectopically", + "resistance", + "sites", + "large", + "binding", + "dissociation", + "assembly", + "dsb", + "showed", "degradation", - "addition", - "interstrand", + "facilitates", + "promoting", "meiosis", - "thus", - "structures", - "dsb", "upon", - "facilitates", - "reduction", - "complex", - "resistance", - "effect", - "propose", - "severe", - "showed", - "assembly", - "controls", - "cancels", - "recombination", - "dsbs", - "able", - "leads", - "egg", "cells", - "dissociation", - "cancer", - "crosslink", - "disruptive", - "binding", + "interlock", + "interacts", + "ectopically", "forms", - "previously", - "breaks" + "extracts", + "recombinase", + "rings", + "recombination", + "cancels", + "crosslink", + "ensures", + "concentrates", + "cancer", + "controls" ], "release_date":"2023-07-05", "publication":"\"BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination\", Sci Adv, 9, eadi7352-eadi7352", @@ -568810,80 +570923,80 @@ "recombination" ], "keywords":[ - "sites", + "breaks", + "complex", + "repair", + "producing", + "homologous", + "octameric", + "timely", + "reduction", + "dsbs", + "egg", + "meiotic", + "hr", + "able", + "structures", + "disruptive", + "xenopus", + "absence", + "previously", + "dna", "hsf2bp", - "control", - "causes", - "dmc1", "trigger", - "large", + "brca2", + "severe", + "effect", + "interstrand", + "hsf2bpbrca2", + "causes", + "addition", + "report", + "leads", + "loading", "rad51", + "also", + "thus", "ring", - "interlock", + "dmc1", + "somatic", + "damage", "brme1", - "dna", + "control", + "propose", + "prevents", "cell", - "damage", - "somatic", - "report", - "also", - "hr", - "repair", - "hsf2bpbrca2", + "recombinases", "oligomerization", - "promoting", - "xenopus", - "octameric", - "rings", - "meiotic", - "interacts", - "homologous", - "extracts", - "concentrates", - "loading", - "ensures", "turnover", - "producing", - "absence", - "recombinase", - "prevents", - "timely", - "brca2", - "recombinases", - "ectopically", + "resistance", + "sites", + "large", + "binding", + "dissociation", + "assembly", + "dsb", + "showed", "degradation", - "addition", - "interstrand", + "facilitates", + "promoting", "meiosis", - "thus", - "structures", - "dsb", "upon", - "facilitates", - "reduction", - "complex", - "resistance", - "effect", - "propose", - "severe", - "showed", - "assembly", - "controls", - "cancels", - "recombination", - "dsbs", - "able", - "leads", - "egg", "cells", - "dissociation", - "cancer", - "crosslink", - "disruptive", - "binding", + "interlock", + "interacts", + "ectopically", "forms", - "previously", - "breaks" + "extracts", + "recombinase", + "rings", + "recombination", + "cancels", + "crosslink", + "ensures", + "concentrates", + "cancer", + "controls" ], "release_date":"2023-07-05", "publication":"\"BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination\", Sci Adv, 9, eadi7352-eadi7352", @@ -568965,25 +571078,37 @@ "forename":"K.", "surname":"Myrtollari" }, + { + "forename":"E.", + "surname":"Calderini" + }, { "forename":"D.", "surname":"Kracher" }, { - "forename":"E.", - "surname":"Calderini" + "forename":"T.", + "surname":"Schongassner" + }, + { + "forename":"S.", + "surname":"Galusic" + }, + { + "forename":"A.", + "surname":"Slavica" }, { "forename":"A.", - "surname":"Schruefer" + "surname":"Taden" }, { "forename":"D.", "surname":"Mokos" }, { - "forename":"B.", - "surname":"Daniel" + "forename":"A.", + "surname":"Schrufer" }, { "forename":"G.", @@ -568993,6 +571118,10 @@ "forename":"K.", "surname":"Gruber" }, + { + "forename":"B.", + "surname":"Daniel" + }, { "forename":"R.", "surname":"Kourist" @@ -569007,31 +571136,134 @@ ], "subtitle":"Structure of the reconstructed ancestor of phenolic acid decarboxylase ancpad134", "tags":[ - "decarboxylation", - "lyase", - "n134", - "bacillus subtilis", "ancestral sequence", - "ancestor", - "phenolic-acid", + "bacillus subtilis", + "phenolic acid decarboxylase", "decarboxylase", - "phenolic acid decarboxylase" + "ancestor", + "lyase", + "n134", + "decarboxylation", + "phenolic-acid" ], "keywords":[ - "description", - "found" + "organic", + "hydrophobic", + "structural", + "key", + "number", + "thermostable", + "reduce", + "three", + "hydroxycinnamic", + "acid", + "regression", + "candidates", + "study", + "accumulation", + "salt", + "stabilization", + "unfolding", + "predicting", + "straightforward", + "systems", + "crystal", + "stable", + "total", + "aqueous", + "deep", + "phenolic", + "proficient", + "experimentally", + "access", + "pool", + "selected", + "thus", + "bridges", + "gives", + "solvents", + "eutectic", + "thermal", + "makes", + "stability", + "approach", + "waste", + "calculated", + "proteins", + "achieved", + "process", + "ancestral", + "enzymes", + "hydrogen", + "enzyme", + "option", + "adhesive", + "biocatalyst", + "set", + "increase", + "surface", + "energy", + "biphasic", + "fit", + "used", + "feature", + "natural", + "yet", + "different", + "clusters", + "16", + "properties", + "application", + "variant", + "bonds", + "enhancing", + "turnover", + "explored", + "industrial", + "resulted", + "ancestors", + "buffers", + "time", + "applied", + "sequence", + "associated", + "production", + "consumption", + "models", + "h", + "identification", + "variants", + "structures", + "reconstruction", + "mixtures", + "enzymatic", + "styrenes", + "rely", + "determined", + "temperature", + "would", + "investigation", + "identify", + "45", + "decarboxylation", + "attributes", + "60", + "acids", + "decarboxylases", + "biobased", + "generate" ], "release_date":"2023-07-05", - "publication":"To be published", + "publication":"\"Stability Increase of Phenolic Acid Decarboxylase by a Combination of Protein and Solvent Engineering Unlocks Applications at Elevated Temperatures\", Acs Sustain Chem Eng, 12, 3575-3584", "publication_ref":{ - "DOI":"", - "PubMed":"", + "DOI":"10.1021\/acssuschemeng.3c06513", + "PubMed":"38456190", "CSD":"", - "ISSN":"", + "ISSN":"2168-0485", "ASTM":"" }, - "publication_country":"", - "abstract":"No description found.", + "publication_country":"US", + "abstract":"Enzymatic decarboxylation of biobased hydroxycinnamic acids gives access to phenolic styrenes for adhesive production. Phenolic acid decarboxylases are proficient enzymes that have been applied in aqueous systems, organic solvents, biphasic systems, and deep eutectic solvents, which makes stability a key feature. Stabilization of the enzyme would increase the total turnover number and thus reduce the energy consumption and waste accumulation associated with biocatalyst production. In this study, we used ancestral sequence reconstruction to generate thermostable decarboxylases. Investigation of a set of 16 ancestors resulted in the identification of a variant with an unfolding temperature of 78.1 \u00b0C and a half-life time of 45 h at 60 \u00b0C. Crystal structures were determined for three selected ancestors. Structural attributes were calculated to fit different regression models for predicting the thermal stability of variants that have not yet been experimentally explored. The models rely on hydrophobic clusters, salt bridges, hydrogen bonds, and surface properties and can identify more stable proteins out of a pool of candidates. Further stabilization was achieved by the application of mixtures of natural deep eutectic solvents and buffers. Our approach is a straightforward option for enhancing the industrial application of the decarboxylation process.", "crystal_structure":{ "length_a":"97.321", "length_b":"106.679", @@ -569052,11 +571284,11 @@ "seq_thr_sim_designed":[ { "sim":292.0, - "partner":"8c66" + "partner":"8adx" }, { "sim":292.0, - "partner":"8adx" + "partner":"8c66" }, { "sim":51.0, @@ -569068,11 +571300,11 @@ }, { "sim":51.0, - "partner":"8etx" + "partner":"8eu1" }, { "sim":51.0, - "partner":"8eu1" + "partner":"8etx" }, { "sim":51.0, @@ -569080,31 +571312,31 @@ }, { "sim":50.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":50.0, - "partner":"8v2x" + "partner":"8v09" }, { "sim":50.0, - "partner":"8w06" + "partner":"8v2w" }, { "sim":50.0, - "partner":"8w08" + "partner":"8v2x" }, { "sim":50.0, - "partner":"8v2w" + "partner":"8w05" }, { "sim":50.0, - "partner":"8w05" + "partner":"8w06" }, { "sim":50.0, - "partner":"8v09" + "partner":"8v0a" } ], "seq_thr_sim_natural":[ @@ -569312,10 +571544,6 @@ "sim":56.0, "partner":"4cp2" }, - { - "sim":56.0, - "partner":"3s3h" - }, { "sim":56.0, "partner":"3s3k" @@ -569328,6 +571556,10 @@ "sim":56.0, "partner":"3s3f" }, + { + "sim":56.0, + "partner":"3s3h" + }, { "sim":56.0, "partner":"4xvc" @@ -569388,14 +571620,6 @@ "sim":55.0, "partner":"7dqb" }, - { - "sim":55.0, - "partner":"5ds3" - }, - { - "sim":55.0, - "partner":"6bhv" - }, { "sim":55.0, "partner":"6ntu" @@ -569422,19 +571646,23 @@ }, { "sim":55.0, - "partner":"3a99" + "partner":"6bhv" }, { "sim":55.0, - "partner":"5hjn" + "partner":"5ds3" }, { "sim":55.0, - "partner":"5hjq" + "partner":"3a99" }, { "sim":55.0, - "partner":"6put" + "partner":"5hjn" + }, + { + "sim":55.0, + "partner":"5hjq" }, { "sim":55.0, @@ -569448,13 +571676,17 @@ "sim":55.0, "partner":"6v3k" }, + { + "sim":55.0, + "partner":"6puz" + }, { "sim":55.0, "partner":"5u1c" }, { "sim":55.0, - "partner":"6puz" + "partner":"6put" }, { "sim":55.0, @@ -569600,10 +571832,6 @@ "sim":54.0, "partner":"7lji" }, - { - "sim":54.0, - "partner":"4acg" - }, { "sim":54.0, "partner":"4ach" @@ -569616,6 +571844,10 @@ "sim":54.0, "partner":"4acd" }, + { + "sim":54.0, + "partner":"4acg" + }, { "sim":54.0, "partner":"7kmn" @@ -569648,10 +571880,6 @@ "sim":54.0, "partner":"6cwz" }, - { - "sim":54.0, - "partner":"5y1h" - }, { "sim":54.0, "partner":"5y1k" @@ -569696,6 +571924,10 @@ "sim":54.0, "partner":"5y3i" }, + { + "sim":54.0, + "partner":"5y1h" + }, { "sim":53.0, "partner":"2lo4" @@ -569726,15 +571958,15 @@ }, { "sim":53.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":53.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":53.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":53.0, @@ -569774,19 +572006,19 @@ }, { "sim":53.0, - "partner":"5c7p" + "partner":"4kpc" }, { "sim":53.0, - "partner":"4kpc" + "partner":"5c7p" }, { "sim":53.0, - "partner":"1x24" + "partner":"1zcl" }, { "sim":53.0, - "partner":"1zcl" + "partner":"1x24" }, { "sim":53.0, @@ -569814,27 +572046,27 @@ }, { "sim":53.0, - "partner":"7mnq" + "partner":"7mns" }, { "sim":53.0, - "partner":"7mnr" + "partner":"7mnt" }, { "sim":53.0, - "partner":"7mns" + "partner":"7mnu" }, { "sim":53.0, - "partner":"7mnt" + "partner":"7mnv" }, { "sim":53.0, - "partner":"7mnu" + "partner":"7mnq" }, { "sim":53.0, - "partner":"7mnv" + "partner":"7mnr" }, { "sim":53.0, @@ -569870,11 +572102,11 @@ }, { "sim":53.0, - "partner":"7e16" + "partner":"1r1z" }, { "sim":53.0, - "partner":"1r1z" + "partner":"7e16" }, { "sim":53.0, @@ -569944,17 +572176,13 @@ "sim":53.0, "partner":"3p2m" }, - { - "sim":53.0, - "partner":"7btm" - }, { "sim":53.0, "partner":"7bsx" }, { "sim":53.0, - "partner":"2ikf" + "partner":"7btm" }, { "sim":53.0, @@ -569986,11 +572214,7 @@ }, { "sim":53.0, - "partner":"6vkk" - }, - { - "sim":53.0, - "partner":"6vkq" + "partner":"2ikf" }, { "sim":53.0, @@ -569998,27 +572222,27 @@ }, { "sim":53.0, - "partner":"5a7v" + "partner":"6vkk" }, { "sim":53.0, - "partner":"7x2n" + "partner":"6vkq" }, { "sim":53.0, - "partner":"7x2x" + "partner":"5a7v" }, { "sim":53.0, - "partner":"7x2s" + "partner":"7x2n" }, { "sim":53.0, - "partner":"3dyh" + "partner":"7x2x" }, { "sim":53.0, - "partner":"4rxd" + "partner":"7x2s" }, { "sim":53.0, @@ -570060,6 +572284,14 @@ "sim":53.0, "partner":"3dyg" }, + { + "sim":53.0, + "partner":"4rxd" + }, + { + "sim":53.0, + "partner":"3dyh" + }, { "sim":53.0, "partner":"8d89" @@ -570082,35 +572314,35 @@ }, { "sim":53.0, - "partner":"2y46" + "partner":"3zsn" }, { "sim":53.0, - "partner":"2y5n" + "partner":"2y98" }, { "sim":53.0, - "partner":"2yca" + "partner":"2y5z" }, { "sim":53.0, - "partner":"3zsn" + "partner":"4aw3" }, { "sim":53.0, - "partner":"2y98" + "partner":"2ygx" }, { "sim":53.0, - "partner":"2y5z" + "partner":"2y46" }, { "sim":53.0, - "partner":"4aw3" + "partner":"2y5n" }, { "sim":53.0, - "partner":"2ygx" + "partner":"2yca" }, { "sim":53.0, @@ -570118,19 +572350,19 @@ }, { "sim":53.0, - "partner":"3ssn" + "partner":"8d19" }, { "sim":53.0, - "partner":"8d19" + "partner":"3ssn" }, { "sim":53.0, - "partner":"3sso" + "partner":"8czk" }, { "sim":53.0, - "partner":"8czk" + "partner":"3sso" }, { "sim":53.0, @@ -570142,11 +572374,11 @@ }, { "sim":53.0, - "partner":"5d40" + "partner":"5d3u" }, { "sim":53.0, - "partner":"5d3u" + "partner":"5d40" }, { "sim":53.0, @@ -570192,10 +572424,6 @@ "sim":53.0, "partner":"3uor" }, - { - "sim":53.0, - "partner":"2wc4" - }, { "sim":53.0, "partner":"1oif" @@ -570310,11 +572538,11 @@ }, { "sim":53.0, - "partner":"6bia" + "partner":"2wc4" }, { "sim":53.0, - "partner":"4dqv" + "partner":"6bia" }, { "sim":53.0, @@ -570322,15 +572550,15 @@ }, { "sim":53.0, - "partner":"5t3b" + "partner":"4dqv" }, { "sim":53.0, - "partner":"7ew8" + "partner":"5t3b" }, { "sim":53.0, - "partner":"6pt4" + "partner":"7ew8" }, { "sim":53.0, @@ -570344,6 +572572,10 @@ "sim":53.0, "partner":"6ptk" }, + { + "sim":53.0, + "partner":"6pt4" + }, { "sim":53.0, "partner":"2inr" @@ -570358,7 +572590,7 @@ }, { "sim":53.0, - "partner":"5m12" + "partner":"6gwg" }, { "sim":53.0, @@ -570366,31 +572598,31 @@ }, { "sim":53.0, - "partner":"6gwf" + "partner":"6gta" }, { "sim":53.0, - "partner":"6gwg" + "partner":"5m16" }, { "sim":53.0, - "partner":"5m16" + "partner":"6gvd" }, { "sim":53.0, - "partner":"6gta" + "partner":"5m0x" }, { "sim":53.0, - "partner":"6gvd" + "partner":"6gx8" }, { "sim":53.0, - "partner":"5m0x" + "partner":"5m12" }, { "sim":53.0, - "partner":"6gx8" + "partner":"6gwf" }, { "sim":53.0, @@ -570568,17 +572800,13 @@ "sim":52.0, "partner":"6fxs" }, - { - "sim":52.0, - "partner":"4o8t" - }, { "sim":52.0, "partner":"4o8l" }, { "sim":52.0, - "partner":"4nsq" + "partner":"4o8t" }, { "sim":52.0, @@ -570588,6 +572816,10 @@ "sim":52.0, "partner":"4ohb" }, + { + "sim":52.0, + "partner":"4nsq" + }, { "sim":52.0, "partner":"2w1q" @@ -570700,21 +572932,17 @@ "sim":52.0, "partner":"3vwu" }, - { - "sim":52.0, - "partner":"6ey1" - }, { "sim":52.0, "partner":"6f0w" }, { "sim":52.0, - "partner":"6vio" + "partner":"6ey1" }, { "sim":52.0, - "partner":"4jyi" + "partner":"6vio" }, { "sim":52.0, @@ -570740,6 +572968,10 @@ "sim":52.0, "partner":"4jyh" }, + { + "sim":52.0, + "partner":"4jyi" + }, { "sim":52.0, "partner":"4q20" @@ -570750,19 +572982,19 @@ }, { "sim":52.0, - "partner":"7a61" + "partner":"8rwq" }, { "sim":52.0, - "partner":"5uj3" + "partner":"6mnp" }, { "sim":52.0, - "partner":"5uj4" + "partner":"8rwr" }, { "sim":52.0, - "partner":"6mnp" + "partner":"5uj3" }, { "sim":52.0, @@ -570770,7 +573002,11 @@ }, { "sim":52.0, - "partner":"5ul8" + "partner":"8rws" + }, + { + "sim":52.0, + "partner":"5uj4" }, { "sim":52.0, @@ -570784,6 +573020,10 @@ "sim":52.0, "partner":"6d17" }, + { + "sim":52.0, + "partner":"5ul8" + }, { "sim":52.0, "partner":"6d18" @@ -570838,15 +573078,15 @@ }, { "sim":52.0, - "partner":"8rwq" + "partner":"6mey" }, { "sim":52.0, - "partner":"6mey" + "partner":"6v1j" }, { "sim":52.0, - "partner":"6v1j" + "partner":"8aki" }, { "sim":52.0, @@ -570854,7 +573094,7 @@ }, { "sim":52.0, - "partner":"8aki" + "partner":"8akj" }, { "sim":52.0, @@ -570866,7 +573106,7 @@ }, { "sim":52.0, - "partner":"8akj" + "partner":"8akk" }, { "sim":52.0, @@ -570874,19 +573114,23 @@ }, { "sim":52.0, - "partner":"8akk" + "partner":"8akl" }, { "sim":52.0, - "partner":"8akl" + "partner":"8akm" }, { "sim":52.0, - "partner":"8akm" + "partner":"7a61" }, { "sim":52.0, - "partner":"4bwa" + "partner":"8rwo" + }, + { + "sim":52.0, + "partner":"8rwp" }, { "sim":52.0, @@ -570970,15 +573214,15 @@ }, { "sim":52.0, - "partner":"5y7x" + "partner":"4bwa" }, { "sim":52.0, - "partner":"3l7v" + "partner":"5y7x" }, { "sim":52.0, - "partner":"3ta4" + "partner":"3l7v" }, { "sim":52.0, @@ -570986,15 +573230,15 @@ }, { "sim":52.0, - "partner":"8r2x" + "partner":"3ta4" }, { "sim":52.0, - "partner":"3k55" + "partner":"8r2x" }, { "sim":52.0, - "partner":"7xif" + "partner":"3k55" }, { "sim":52.0, @@ -571008,6 +573252,10 @@ "sim":52.0, "partner":"7xii" }, + { + "sim":52.0, + "partner":"7xif" + }, { "sim":52.0, "partner":"3i5v" @@ -571042,51 +573290,51 @@ }, { "sim":52.0, - "partner":"7q2b" + "partner":"7q2f" }, { "sim":52.0, - "partner":"3ha3" + "partner":"7q2g" }, { "sim":52.0, - "partner":"7q2c" + "partner":"7q2h" }, { "sim":52.0, - "partner":"7q2d" + "partner":"3ha5" }, { "sim":52.0, - "partner":"7q2e" + "partner":"2fk7" }, { "sim":52.0, - "partner":"7q2f" + "partner":"2fk8" }, { "sim":52.0, - "partner":"7q2g" + "partner":"3ha7" }, { "sim":52.0, - "partner":"7q2h" + "partner":"7q2b" }, { "sim":52.0, - "partner":"3ha5" + "partner":"7q2c" }, { "sim":52.0, - "partner":"2fk7" + "partner":"3ha3" }, { "sim":52.0, - "partner":"2fk8" + "partner":"7q2d" }, { "sim":52.0, - "partner":"3ha7" + "partner":"7q2e" }, { "sim":52.0, @@ -571118,19 +573366,19 @@ }, { "sim":52.0, - "partner":"7q4u" + "partner":"7zf2" }, { "sim":52.0, - "partner":"7q59" + "partner":"7q4u" }, { "sim":52.0, - "partner":"7pp4" + "partner":"7q59" }, { "sim":52.0, - "partner":"7zf2" + "partner":"7pp4" }, { "sim":52.0, @@ -571170,15 +573418,15 @@ }, { "sim":52.0, - "partner":"2o0h" + "partner":"2o0j" }, { "sim":52.0, - "partner":"2o0j" + "partner":"2o0k" }, { "sim":52.0, - "partner":"2o0k" + "partner":"2o0h" }, { "sim":52.0, @@ -571194,15 +573442,15 @@ }, { "sim":52.0, - "partner":"6s0g" + "partner":"7bn6" }, { "sim":52.0, - "partner":"7bn6" + "partner":"6s23" }, { "sim":52.0, - "partner":"6s23" + "partner":"6s0g" }, { "sim":52.0, @@ -571226,11 +573474,11 @@ }, { "sim":52.0, - "partner":"8a6w" + "partner":"8s53" }, { "sim":52.0, - "partner":"5dvi" + "partner":"8a6w" }, { "sim":52.0, @@ -571242,7 +573490,7 @@ }, { "sim":52.0, - "partner":"5w2o" + "partner":"5dvi" }, { "sim":52.0, @@ -571258,11 +573506,11 @@ }, { "sim":52.0, - "partner":"4ine" + "partner":"5w2o" }, { "sim":52.0, - "partner":"2z67" + "partner":"4ine" }, { "sim":52.0, @@ -571270,28 +573518,16 @@ }, { "sim":52.0, - "partner":"4wya" - }, - { - "sim":52.0, - "partner":"4wyf" - }, - { - "sim":52.0, - "partner":"4cxq" + "partner":"2z67" }, { "sim":52.0, - "partner":"5kgs" + "partner":"4cxr" }, { "sim":52.0, "partner":"4wyg" }, - { - "sim":52.0, - "partner":"4cxr" - }, { "sim":52.0, "partner":"4xjl" @@ -571356,10 +573592,26 @@ "sim":52.0, "partner":"3tfu" }, + { + "sim":52.0, + "partner":"4wya" + }, { "sim":52.0, "partner":"4wye" }, + { + "sim":52.0, + "partner":"4wyf" + }, + { + "sim":52.0, + "partner":"4cxq" + }, + { + "sim":52.0, + "partner":"5kgs" + }, { "sim":52.0, "partner":"4zm3" @@ -571406,19 +573658,19 @@ }, { "sim":52.0, - "partner":"6vzy" + "partner":"6xcv" }, { "sim":52.0, - "partner":"6xcv" + "partner":"6vzy" }, { "sim":52.0, - "partner":"4mdo" + "partner":"4mdp" }, { "sim":52.0, - "partner":"4mdp" + "partner":"4mdo" }, { "sim":52.0, @@ -571474,27 +573726,27 @@ }, { "sim":52.0, - "partner":"4j3t" + "partner":"4j3v" }, { "sim":52.0, - "partner":"4j3u" + "partner":"4j3w" }, { "sim":52.0, - "partner":"4j3v" + "partner":"4j3x" }, { "sim":52.0, - "partner":"4j3w" + "partner":"4j3s" }, { "sim":52.0, - "partner":"4j3x" + "partner":"4j3t" }, { "sim":52.0, - "partner":"4j3s" + "partner":"4j3u" }, { "sim":52.0, @@ -571668,10 +573920,6 @@ "sim":51.0, "partner":"5t4x" }, - { - "sim":51.0, - "partner":"7xtl" - }, { "sim":51.0, "partner":"6o3w" @@ -571686,19 +573934,15 @@ }, { "sim":51.0, - "partner":"3kh7" - }, - { - "sim":51.0, - "partner":"3kh9" + "partner":"7xtl" }, { "sim":51.0, - "partner":"5scp" + "partner":"3kh7" }, { "sim":51.0, - "partner":"5scq" + "partner":"3kh9" }, { "sim":51.0, @@ -571802,16 +574046,24 @@ }, { "sim":51.0, - "partner":"5ujf" + "partner":"5scp" }, { "sim":51.0, - "partner":"5k24" + "partner":"5scq" + }, + { + "sim":51.0, + "partner":"5ujf" }, { "sim":51.0, "partner":"5k22" }, + { + "sim":51.0, + "partner":"5k24" + }, { "sim":51.0, "partner":"6vsx" @@ -571836,10 +574088,6 @@ "sim":51.0, "partner":"4nje" }, - { - "sim":51.0, - "partner":"3l1u" - }, { "sim":51.0, "partner":"3l1v" @@ -571856,6 +574104,10 @@ "sim":51.0, "partner":"3esr" }, + { + "sim":51.0, + "partner":"3l1u" + }, { "sim":51.0, "partner":"4h3k" @@ -571910,11 +574162,11 @@ }, { "sim":51.0, - "partner":"1wc6" + "partner":"1wc1" }, { "sim":51.0, - "partner":"1wc1" + "partner":"1wc6" }, { "sim":51.0, @@ -571934,16 +574186,12 @@ }, { "sim":51.0, - "partner":"7o2t" + "partner":"6z17" }, { "sim":51.0, "partner":"7o2u" }, - { - "sim":51.0, - "partner":"6z17" - }, { "sim":51.0, "partner":"6yz3" @@ -571960,6 +574208,10 @@ "sim":51.0, "partner":"6z5k" }, + { + "sim":51.0, + "partner":"7o2t" + }, { "sim":51.0, "partner":"1zw9" @@ -572032,10 +574284,6 @@ "sim":51.0, "partner":"6kzh" }, - { - "sim":51.0, - "partner":"6o98" - }, { "sim":51.0, "partner":"7jh2" @@ -572048,6 +574296,10 @@ "sim":51.0, "partner":"6xfv" }, + { + "sim":51.0, + "partner":"6o98" + }, { "sim":51.0, "partner":"5du0" @@ -572078,35 +574330,35 @@ }, { "sim":51.0, - "partner":"6ub4" + "partner":"6ub2" }, { "sim":51.0, - "partner":"6ub5" + "partner":"6ub3" }, { "sim":51.0, - "partner":"6ub6" + "partner":"6ub4" }, { "sim":51.0, - "partner":"6ub2" + "partner":"6ub5" }, { "sim":51.0, - "partner":"6ub3" + "partner":"6ub6" }, { "sim":51.0, - "partner":"1z5z" + "partner":"2f9t" }, { "sim":51.0, - "partner":"2f9t" + "partner":"2f9w" }, { "sim":51.0, - "partner":"2f9w" + "partner":"1z5z" }, { "sim":51.0, @@ -572150,15 +574402,15 @@ }, { "sim":51.0, - "partner":"6t2p" + "partner":"6t2o" }, { "sim":51.0, - "partner":"6t2q" + "partner":"6t2p" }, { "sim":51.0, - "partner":"6t2o" + "partner":"6t2q" }, { "sim":51.0, @@ -572168,14 +574420,6 @@ "sim":51.0, "partner":"3ceq" }, - { - "sim":51.0, - "partner":"7kqj" - }, - { - "sim":51.0, - "partner":"6vqf" - }, { "sim":51.0, "partner":"7kxd" @@ -572220,6 +574464,14 @@ "sim":51.0, "partner":"7luk" }, + { + "sim":51.0, + "partner":"6vqf" + }, + { + "sim":51.0, + "partner":"7kqj" + }, { "sim":51.0, "partner":"5djf" @@ -572230,11 +574482,11 @@ }, { "sim":51.0, - "partner":"5djh" + "partner":"7xm0" }, { "sim":51.0, - "partner":"7xm0" + "partner":"5djh" }, { "sim":51.0, @@ -572300,10 +574552,6 @@ "sim":51.0, "partner":"5teu" }, - { - "sim":51.0, - "partner":"4pgc" - }, { "sim":51.0, "partner":"4pgd" @@ -572322,11 +574570,7 @@ }, { "sim":51.0, - "partner":"6dcb" - }, - { - "sim":51.0, - "partner":"6dcc" + "partner":"4pgc" }, { "sim":51.0, @@ -572344,6 +574588,14 @@ "sim":51.0, "partner":"3vnh" }, + { + "sim":51.0, + "partner":"6dcb" + }, + { + "sim":51.0, + "partner":"6dcc" + }, { "sim":51.0, "partner":"4rnc" @@ -572368,10 +574620,6 @@ "sim":51.0, "partner":"6oxh" }, - { - "sim":51.0, - "partner":"5ybr" - }, { "sim":51.0, "partner":"5ybs" @@ -572400,6 +574648,10 @@ "sim":51.0, "partner":"5ybq" }, + { + "sim":51.0, + "partner":"5ybr" + }, { "sim":51.0, "partner":"1ynp" @@ -572492,10 +574744,6 @@ "sim":51.0, "partner":"4bfa" }, - { - "sim":51.0, - "partner":"2pt0" - }, { "sim":51.0, "partner":"3d1o" @@ -572518,11 +574766,7 @@ }, { "sim":51.0, - "partner":"5gg5" - }, - { - "sim":51.0, - "partner":"5xd1" + "partner":"2pt0" }, { "sim":51.0, @@ -572538,27 +574782,27 @@ }, { "sim":51.0, - "partner":"5gg7" + "partner":"6m6y" }, { "sim":51.0, - "partner":"5xd4" + "partner":"5gg7" }, { "sim":51.0, - "partner":"5xd5" + "partner":"5xd4" }, { "sim":51.0, - "partner":"6m6y" + "partner":"6m65" }, { "sim":51.0, - "partner":"5gg8" + "partner":"5xd5" }, { "sim":51.0, - "partner":"6m65" + "partner":"5gg8" }, { "sim":51.0, @@ -572592,6 +574836,14 @@ "sim":51.0, "partner":"6m69" }, + { + "sim":51.0, + "partner":"5gg5" + }, + { + "sim":51.0, + "partner":"5xd1" + }, { "sim":51.0, "partner":"8bfr" @@ -572606,27 +574858,27 @@ }, { "sim":51.0, - "partner":"4mfj" + "partner":"4mfl" }, { "sim":51.0, - "partner":"4mfk" + "partner":"4mfp" }, { "sim":51.0, - "partner":"4mfl" + "partner":"4mfq" }, { "sim":51.0, - "partner":"6iix" + "partner":"4mfj" }, { "sim":51.0, - "partner":"4mfp" + "partner":"6iix" }, { "sim":51.0, - "partner":"4mfq" + "partner":"4mfk" }, { "sim":51.0, @@ -572658,15 +574910,15 @@ }, { "sim":51.0, - "partner":"6vat" + "partner":"6vc7" }, { "sim":51.0, - "partner":"6vc7" + "partner":"6vdf" }, { "sim":51.0, - "partner":"6vdf" + "partner":"6vat" }, { "sim":51.0, @@ -572690,23 +574942,19 @@ }, { "sim":51.0, - "partner":"5eeg" - }, - { - "sim":51.0, - "partner":"5jr3" + "partner":"5eeh" }, { "sim":51.0, - "partner":"5eeh" + "partner":"2nqo" }, { "sim":51.0, - "partner":"2nqo" + "partner":"5eeg" }, { "sim":51.0, - "partner":"3c1y" + "partner":"5jr3" }, { "sim":51.0, @@ -572734,12 +574982,16 @@ }, { "sim":51.0, - "partner":"4zhs" + "partner":"3c1y" }, { "sim":51.0, "partner":"4zic" }, + { + "sim":51.0, + "partner":"4zhs" + }, { "sim":51.0, "partner":"4ot7" @@ -572774,11 +575026,11 @@ }, { "sim":51.0, - "partner":"4wwv" + "partner":"6c8v" }, { "sim":51.0, - "partner":"6c8v" + "partner":"4wwv" }, { "sim":51.0, @@ -572830,11 +575082,11 @@ }, { "sim":51.0, - "partner":"4ak5" + "partner":"7k14" }, { "sim":51.0, - "partner":"7k14" + "partner":"4ak5" }, { "sim":51.0, @@ -572872,17 +575124,13 @@ "sim":51.0, "partner":"4ov9" }, - { - "sim":51.0, - "partner":"2gqn" - }, { "sim":51.0, "partner":"2fq6" }, { "sim":51.0, - "partner":"4lre" + "partner":"2gqn" }, { "sim":51.0, @@ -572916,6 +575164,10 @@ "sim":51.0, "partner":"4lrd" }, + { + "sim":51.0, + "partner":"4lre" + }, { "sim":51.0, "partner":"6pcz" @@ -572946,15 +575198,15 @@ }, { "sim":51.0, - "partner":"7cl7" + "partner":"6l69" }, { "sim":51.0, - "partner":"7cl8" + "partner":"7cl7" }, { "sim":51.0, - "partner":"6l69" + "partner":"7cl8" }, { "sim":51.0, @@ -572976,14 +575228,6 @@ "sim":51.0, "partner":"2w7y" }, - { - "sim":51.0, - "partner":"6j87" - }, - { - "sim":51.0, - "partner":"6j88" - }, { "sim":51.0, "partner":"6j85" @@ -572994,15 +575238,15 @@ }, { "sim":51.0, - "partner":"4doy" + "partner":"6j87" }, { "sim":51.0, - "partner":"6v99" + "partner":"6j88" }, { "sim":51.0, - "partner":"6v9a" + "partner":"4doy" }, { "sim":51.0, @@ -573010,19 +575254,11 @@ }, { "sim":51.0, - "partner":"4tm4" - }, - { - "sim":51.0, - "partner":"6ry0" - }, - { - "sim":51.0, - "partner":"6ry1" + "partner":"6v99" }, { "sim":51.0, - "partner":"6ry2" + "partner":"6v9a" }, { "sim":51.0, @@ -573056,6 +575292,22 @@ "sim":51.0, "partner":"4tm3" }, + { + "sim":51.0, + "partner":"6ry0" + }, + { + "sim":51.0, + "partner":"4tm4" + }, + { + "sim":51.0, + "partner":"6ry1" + }, + { + "sim":51.0, + "partner":"6ry2" + }, { "sim":51.0, "partner":"6ymd" @@ -573102,15 +575354,15 @@ }, { "sim":51.0, - "partner":"7tfc" + "partner":"7tfe" }, { "sim":51.0, - "partner":"7tfe" + "partner":"7tf9" }, { "sim":51.0, - "partner":"7tf9" + "partner":"7tfc" }, { "sim":51.0, @@ -573142,15 +575394,15 @@ }, { "sim":51.0, - "partner":"7f79" + "partner":"5o86" }, { "sim":51.0, - "partner":"5o86" + "partner":"6ewx" }, { "sim":51.0, - "partner":"6ewx" + "partner":"7f77" }, { "sim":51.0, @@ -573162,7 +575414,7 @@ }, { "sim":51.0, - "partner":"7f77" + "partner":"7f79" }, { "sim":51.0, @@ -573176,10 +575428,6 @@ "sim":51.0, "partner":"3khz" }, - { - "sim":51.0, - "partner":"6x0h" - }, { "sim":51.0, "partner":"6x0j" @@ -573196,6 +575444,10 @@ "sim":51.0, "partner":"6jzs" }, + { + "sim":51.0, + "partner":"6x0h" + }, { "sim":51.0, "partner":"6ta8" @@ -573222,11 +575474,11 @@ }, { "sim":51.0, - "partner":"7an1" + "partner":"7oqd" }, { "sim":51.0, - "partner":"7oqd" + "partner":"7an1" }, { "sim":51.0, @@ -573252,10 +575504,6 @@ "sim":51.0, "partner":"7p24" }, - { - "sim":51.0, - "partner":"7y1s" - }, { "sim":51.0, "partner":"2j3n" @@ -573270,11 +575518,11 @@ }, { "sim":51.0, - "partner":"7oza" + "partner":"7y1s" }, { "sim":51.0, - "partner":"5kdn" + "partner":"7oza" }, { "sim":51.0, @@ -573284,6 +575532,10 @@ "sim":51.0, "partner":"5kdu" }, + { + "sim":51.0, + "partner":"5kdn" + }, { "sim":51.0, "partner":"6xsz" @@ -573322,15 +575574,15 @@ }, { "sim":51.0, - "partner":"2vbg" + "partner":"5ing" }, { "sim":51.0, - "partner":"5ing" + "partner":"2vbf" }, { "sim":51.0, - "partner":"2vbf" + "partner":"2vbg" }, { "sim":51.0, @@ -573382,11 +575634,11 @@ }, { "sim":51.0, - "partner":"7jwf" + "partner":"7jw4" }, { "sim":51.0, - "partner":"7jw4" + "partner":"7jwf" }, { "sim":51.0, @@ -573434,15 +575686,15 @@ }, { "sim":51.0, - "partner":"2bpo" + "partner":"2bf4" }, { "sim":51.0, - "partner":"2bf4" + "partner":"2bn4" }, { "sim":51.0, - "partner":"2bn4" + "partner":"2bpo" }, { "sim":51.0, @@ -573486,15 +575738,15 @@ }, { "sim":51.0, - "partner":"6jr8" + "partner":"6jr6" }, { "sim":51.0, - "partner":"6jr6" + "partner":"6jr7" }, { "sim":51.0, - "partner":"6jr7" + "partner":"6jr8" }, { "sim":51.0, @@ -573518,15 +575770,15 @@ }, { "sim":51.0, - "partner":"6tsh" + "partner":"6tsk" }, { "sim":51.0, - "partner":"6tte" + "partner":"6tsh" }, { "sim":51.0, - "partner":"6tsk" + "partner":"6tte" }, { "sim":51.0, @@ -573636,10 +575888,6 @@ "sim":50.0, "partner":"1te4" }, - { - "sim":50.0, - "partner":"4hmr" - }, { "sim":50.0, "partner":"7u0u" @@ -573664,6 +575912,10 @@ "sim":50.0, "partner":"1yx3" }, + { + "sim":50.0, + "partner":"4hmr" + }, { "sim":50.0, "partner":"4yxh" @@ -573690,15 +575942,15 @@ }, { "sim":50.0, - "partner":"3qna" + "partner":"3qn0" }, { "sim":50.0, - "partner":"3qn0" + "partner":"3qn9" }, { "sim":50.0, - "partner":"3qn9" + "partner":"3qna" }, { "sim":50.0, @@ -573734,19 +575986,19 @@ }, { "sim":50.0, - "partner":"6tq2" + "partner":"6tq1" }, { "sim":50.0, - "partner":"6tq1" + "partner":"6tq2" }, { "sim":50.0, - "partner":"6suj" + "partner":"6slc" }, { "sim":50.0, - "partner":"6slc" + "partner":"6suj" }, { "sim":50.0, @@ -573788,10 +576040,6 @@ "sim":50.0, "partner":"2d38" }, - { - "sim":50.0, - "partner":"4gzc" - }, { "sim":50.0, "partner":"4gzd" @@ -573808,6 +576056,10 @@ "sim":50.0, "partner":"4egs" }, + { + "sim":50.0, + "partner":"4gzc" + }, { "sim":50.0, "partner":"2az1" @@ -573904,14 +576156,6 @@ "sim":50.0, "partner":"5jzv" }, - { - "sim":50.0, - "partner":"2wst" - }, - { - "sim":50.0, - "partner":"5l9k" - }, { "sim":50.0, "partner":"5l9q" @@ -573930,11 +576174,11 @@ }, { "sim":50.0, - "partner":"6pj9" + "partner":"2wst" }, { "sim":50.0, - "partner":"6pja" + "partner":"5l9k" }, { "sim":50.0, @@ -573942,11 +576186,11 @@ }, { "sim":50.0, - "partner":"5f5b" + "partner":"6pjq" }, { "sim":50.0, - "partner":"6pjq" + "partner":"5f5b" }, { "sim":50.0, @@ -573954,15 +576198,15 @@ }, { "sim":50.0, - "partner":"4njn" + "partner":"6pju" }, { "sim":50.0, - "partner":"5f5d" + "partner":"4njn" }, { "sim":50.0, - "partner":"6pju" + "partner":"5f5d" }, { "sim":50.0, @@ -573986,15 +576230,19 @@ }, { "sim":50.0, - "partner":"5f5j" + "partner":"6pj5" }, { "sim":50.0, - "partner":"6pj5" + "partner":"6pj7" }, { "sim":50.0, - "partner":"6pj7" + "partner":"5f5j" + }, + { + "sim":50.0, + "partner":"6pj8" }, { "sim":50.0, @@ -574002,7 +576250,11 @@ }, { "sim":50.0, - "partner":"6pj8" + "partner":"6pj9" + }, + { + "sim":50.0, + "partner":"6pja" }, { "sim":50.0, @@ -574030,11 +576282,11 @@ }, { "sim":50.0, - "partner":"6zlq" + "partner":"6utl" }, { "sim":50.0, - "partner":"6utl" + "partner":"6zlq" }, { "sim":50.0, @@ -574058,19 +576310,19 @@ }, { "sim":50.0, - "partner":"5n7o" + "partner":"6hry" }, { "sim":50.0, - "partner":"6hry" + "partner":"5n7o" }, { "sim":50.0, - "partner":"5n1c" + "partner":"6hrz" }, { "sim":50.0, - "partner":"6hrz" + "partner":"5n1c" }, { "sim":50.0, @@ -574094,11 +576346,11 @@ }, { "sim":50.0, - "partner":"6a8x" + "partner":"1upi" }, { "sim":50.0, - "partner":"1upi" + "partner":"6a8x" }, { "sim":50.0, @@ -574118,19 +576370,19 @@ }, { "sim":50.0, - "partner":"8vip" + "partner":"8vit" }, { "sim":50.0, - "partner":"8viq" + "partner":"8vip" }, { "sim":50.0, - "partner":"8vir" + "partner":"8viq" }, { "sim":50.0, - "partner":"8vit" + "partner":"8vir" }, { "sim":50.0, @@ -574162,11 +576414,11 @@ }, { "sim":50.0, - "partner":"6a38" + "partner":"6lq9" }, { "sim":50.0, - "partner":"6lq9" + "partner":"6a38" }, { "sim":50.0, @@ -574220,10 +576472,6 @@ "sim":50.0, "partner":"2whu" }, - { - "sim":50.0, - "partner":"5cvd" - }, { "sim":50.0, "partner":"5cve" @@ -574236,6 +576484,10 @@ "sim":50.0, "partner":"3qc1" }, + { + "sim":50.0, + "partner":"5cvd" + }, { "sim":50.0, "partner":"7qej" @@ -574292,10 +576544,6 @@ "sim":50.0, "partner":"1e42" }, - { - "sim":50.0, - "partner":"5h5a" - }, { "sim":50.0, "partner":"5h54" @@ -574306,15 +576554,15 @@ }, { "sim":50.0, - "partner":"3h1z" + "partner":"5h5a" }, { "sim":50.0, - "partner":"3hs9" + "partner":"3h1z" }, { "sim":50.0, - "partner":"4be6" + "partner":"3hs9" }, { "sim":50.0, @@ -574336,6 +576584,10 @@ "sim":50.0, "partner":"4be5" }, + { + "sim":50.0, + "partner":"4be6" + }, { "sim":50.0, "partner":"5du6" @@ -574404,26 +576656,18 @@ "sim":50.0, "partner":"4jlj" }, - { - "sim":50.0, - "partner":"7zi1" - }, { "sim":50.0, "partner":"4kcg" }, { "sim":50.0, - "partner":"7zi2" + "partner":"7zi3" }, { "sim":50.0, "partner":"4jlk" }, - { - "sim":50.0, - "partner":"7zi3" - }, { "sim":50.0, "partner":"2no6" @@ -574480,13 +576724,17 @@ "sim":50.0, "partner":"4q1e" }, + { + "sim":50.0, + "partner":"7zi5" + }, { "sim":50.0, "partner":"4q1f" }, { "sim":50.0, - "partner":"7zi5" + "partner":"7zi6" }, { "sim":50.0, @@ -574494,11 +576742,11 @@ }, { "sim":50.0, - "partner":"7zi6" + "partner":"7zi7" }, { "sim":50.0, - "partner":"7zi7" + "partner":"7zi8" }, { "sim":50.0, @@ -574506,7 +576754,7 @@ }, { "sim":50.0, - "partner":"7zi8" + "partner":"7zi9" }, { "sim":50.0, @@ -574518,15 +576766,19 @@ }, { "sim":50.0, - "partner":"7zi9" + "partner":"7zia" }, { "sim":50.0, - "partner":"7zia" + "partner":"7zib" }, { "sim":50.0, - "partner":"7zib" + "partner":"7zi1" + }, + { + "sim":50.0, + "partner":"7zi2" }, { "sim":50.0, @@ -574542,11 +576794,11 @@ }, { "sim":50.0, - "partner":"2wk1" + "partner":"6akv" }, { "sim":50.0, - "partner":"6akv" + "partner":"2wk1" }, { "sim":50.0, @@ -574554,11 +576806,11 @@ }, { "sim":50.0, - "partner":"4rni" + "partner":"4rnj" }, { "sim":50.0, - "partner":"4rnj" + "partner":"4rni" }, { "sim":50.0, @@ -574732,10 +576984,6 @@ "sim":50.0, "partner":"4l5a" }, - { - "sim":50.0, - "partner":"2qj3" - }, { "sim":50.0, "partner":"5nji" @@ -574752,6 +577000,10 @@ "sim":50.0, "partner":"5i0k" }, + { + "sim":50.0, + "partner":"2qj3" + }, { "sim":50.0, "partner":"5l84" @@ -574792,14 +577044,6 @@ "sim":50.0, "partner":"3g9h" }, - { - "sim":50.0, - "partner":"2nq6" - }, - { - "sim":50.0, - "partner":"2nq7" - }, { "sim":50.0, "partner":"2b3k" @@ -574842,11 +577086,11 @@ }, { "sim":50.0, - "partner":"7v52" + "partner":"2nq6" }, { "sim":50.0, - "partner":"7v54" + "partner":"2nq7" }, { "sim":50.0, @@ -574866,7 +577110,11 @@ }, { "sim":50.0, - "partner":"6lcn" + "partner":"7v52" + }, + { + "sim":50.0, + "partner":"7v54" }, { "sim":50.0, @@ -574884,6 +577132,10 @@ "sim":50.0, "partner":"6wyn" }, + { + "sim":50.0, + "partner":"6lcn" + }, { "sim":50.0, "partner":"7f8d" @@ -574954,15 +577206,15 @@ }, { "sim":50.0, - "partner":"1t9s" + "partner":"4l3f" }, { "sim":50.0, - "partner":"4l3f" + "partner":"1tbf" }, { "sim":50.0, - "partner":"1tbf" + "partner":"1t9s" }, { "sim":50.0, @@ -574992,10 +577244,6 @@ "sim":50.0, "partner":"4rhq" }, - { - "sim":50.0, - "partner":"7ajm" - }, { "sim":50.0, "partner":"7a4r" @@ -575018,23 +577266,7 @@ }, { "sim":50.0, - "partner":"7a53" - }, - { - "sim":50.0, - "partner":"7ajw" - }, - { - "sim":50.0, - "partner":"7akb" - }, - { - "sim":50.0, - "partner":"7ajy" - }, - { - "sim":50.0, - "partner":"7a5l" + "partner":"7ajm" }, { "sim":50.0, @@ -575074,11 +577306,11 @@ }, { "sim":50.0, - "partner":"4ilk" + "partner":"7aja" }, { "sim":50.0, - "partner":"7aja" + "partner":"4ilk" }, { "sim":50.0, @@ -575100,33 +577332,37 @@ "sim":50.0, "partner":"7aka" }, + { + "sim":50.0, + "partner":"7a53" + }, { "sim":50.0, "partner":"7akl" }, { "sim":50.0, - "partner":"6nor" + "partner":"7ajw" }, { "sim":50.0, - "partner":"5ch9" + "partner":"7akb" }, { "sim":50.0, - "partner":"6fm0" + "partner":"7ajy" }, { "sim":50.0, - "partner":"6rm2" + "partner":"7a5l" }, { "sim":50.0, - "partner":"6fko" + "partner":"6nor" }, { "sim":50.0, - "partner":"6fm1" + "partner":"5ch9" }, { "sim":50.0, @@ -575136,6 +577372,22 @@ "sim":50.0, "partner":"6flf" }, + { + "sim":50.0, + "partner":"6fm0" + }, + { + "sim":50.0, + "partner":"6rm2" + }, + { + "sim":50.0, + "partner":"6fko" + }, + { + "sim":50.0, + "partner":"6fm1" + }, { "sim":50.0, "partner":"6clw" @@ -575204,14 +577456,6 @@ "sim":50.0, "partner":"5zyb" }, - { - "sim":50.0, - "partner":"4q3r" - }, - { - "sim":50.0, - "partner":"4q42" - }, { "sim":50.0, "partner":"4q3s" @@ -575246,11 +577490,11 @@ }, { "sim":50.0, - "partner":"7azd" + "partner":"4q3r" }, { "sim":50.0, - "partner":"7dmb" + "partner":"4q42" }, { "sim":50.0, @@ -575282,16 +577526,24 @@ }, { "sim":50.0, - "partner":"5x06" + "partner":"7azg" }, { "sim":50.0, - "partner":"7azg" + "partner":"5x06" }, { "sim":50.0, "partner":"7azc" }, + { + "sim":50.0, + "partner":"7azd" + }, + { + "sim":50.0, + "partner":"7dmb" + }, { "sim":50.0, "partner":"6d5a" @@ -575302,23 +577554,23 @@ }, { "sim":50.0, - "partner":"6zgp" + "partner":"6y9d" }, { "sim":50.0, - "partner":"6y8j" + "partner":"6zgp" }, { "sim":50.0, - "partner":"6y9c" + "partner":"6y8s" }, { "sim":50.0, - "partner":"6y9d" + "partner":"6y8j" }, { "sim":50.0, - "partner":"6y8s" + "partner":"6y9c" }, { "sim":50.0, @@ -575334,19 +577586,19 @@ }, { "sim":50.0, - "partner":"5oyc" + "partner":"6ha9" }, { "sim":50.0, - "partner":"6ha9" + "partner":"5oyc" }, { "sim":50.0, - "partner":"5oyd" + "partner":"6haa" }, { "sim":50.0, - "partner":"6haa" + "partner":"5oyd" }, { "sim":50.0, @@ -575384,10 +577636,6 @@ "sim":50.0, "partner":"3kki" }, - { - "sim":50.0, - "partner":"5hy0" - }, { "sim":50.0, "partner":"5hy2" @@ -575420,6 +577668,10 @@ "sim":50.0, "partner":"7p1o" }, + { + "sim":50.0, + "partner":"5hy0" + }, { "sim":50.0, "partner":"5cee" @@ -575480,10 +577732,6 @@ "sim":50.0, "partner":"6r63" }, - { - "sim":50.0, - "partner":"5cu7" - }, { "sim":50.0, "partner":"5wgb" @@ -575504,6 +577752,10 @@ "sim":50.0, "partner":"5usr" }, + { + "sim":50.0, + "partner":"5cu7" + }, { "sim":50.0, "partner":"3ihm" @@ -575514,27 +577766,27 @@ }, { "sim":50.0, - "partner":"2yhg" + "partner":"4q6m" }, { "sim":50.0, - "partner":"4q6q" + "partner":"4q6n" }, { "sim":50.0, - "partner":"4q6m" + "partner":"4q6o" }, { "sim":50.0, - "partner":"4q6n" + "partner":"4q6p" }, { "sim":50.0, - "partner":"4q6o" + "partner":"2yhg" }, { "sim":50.0, - "partner":"4q6p" + "partner":"4q6q" }, { "sim":50.0, @@ -575610,23 +577862,27 @@ }, { "sim":50.0, - "partner":"4gt2" + "partner":"3cmj" }, { "sim":50.0, - "partner":"3cmj" + "partner":"8wn5" }, { "sim":50.0, - "partner":"2j63" + "partner":"8wn6" }, { "sim":50.0, - "partner":"6mlh" + "partner":"8wna" }, { "sim":50.0, - "partner":"6mlw" + "partner":"4gt2" + }, + { + "sim":50.0, + "partner":"2j63" }, { "sim":50.0, @@ -575654,11 +577910,15 @@ }, { "sim":50.0, - "partner":"6j0u" + "partner":"6mlh" }, { "sim":50.0, - "partner":"6ak4" + "partner":"6mlw" + }, + { + "sim":50.0, + "partner":"6j0u" }, { "sim":50.0, @@ -575682,7 +577942,7 @@ }, { "sim":50.0, - "partner":"5dt7" + "partner":"6ak4" }, { "sim":50.0, @@ -575692,6 +577952,10 @@ "sim":50.0, "partner":"5dt5" }, + { + "sim":50.0, + "partner":"5dt7" + }, { "sim":50.0, "partner":"4dod" @@ -575740,10 +578004,6 @@ "sim":50.0, "partner":"3udt" }, - { - "sim":50.0, - "partner":"4ie7" - }, { "sim":50.0, "partner":"4cxw" @@ -575762,15 +578022,15 @@ }, { "sim":50.0, - "partner":"4idz" + "partner":"7e8z" }, { "sim":50.0, - "partner":"4ie0" + "partner":"4idz" }, { "sim":50.0, - "partner":"7e8z" + "partner":"4ie0" }, { "sim":50.0, @@ -575788,6 +578048,10 @@ "sim":50.0, "partner":"4qho" }, + { + "sim":50.0, + "partner":"4ie7" + }, { "sim":50.0, "partner":"6yyh" @@ -575830,23 +578094,23 @@ }, { "sim":50.0, - "partner":"7aqu" + "partner":"7cu0" }, { "sim":50.0, - "partner":"7aqv" + "partner":"7cu1" }, { "sim":50.0, - "partner":"7cu0" + "partner":"7cu2" }, { "sim":50.0, - "partner":"7cu1" + "partner":"7aqu" }, { "sim":50.0, - "partner":"7cu2" + "partner":"7aqv" }, { "sim":50.0, @@ -576018,15 +578282,15 @@ }, { "sim":50.0, - "partner":"7w1c" + "partner":"7w1d" }, { "sim":50.0, - "partner":"7w1d" + "partner":"7w1e" }, { "sim":50.0, - "partner":"7w1e" + "partner":"7w1c" }, { "sim":50.0, @@ -576092,10 +578356,6 @@ "sim":50.0, "partner":"2ymw" }, - { - "sim":50.0, - "partner":"7wlg" - }, { "sim":50.0, "partner":"7wj9" @@ -576124,6 +578384,10 @@ "sim":50.0, "partner":"7wjf" }, + { + "sim":50.0, + "partner":"7wlg" + }, { "sim":50.0, "partner":"2wda" @@ -576146,15 +578410,15 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"6edz" }, { "sim":50.0, - "partner":"6edz" + "partner":"6ee1" }, { "sim":50.0, - "partner":"6ee1" + "partner":"6edw" }, { "sim":50.0, @@ -576300,7 +578564,7 @@ ], "seq_max_sim_designed":{ "sim":292.0, - "partner":"8c66" + "partner":"8adx" }, "seq_max_sim_natural":{ "sim":232.0, @@ -576336,13 +578600,29 @@ "forename":"K.", "surname":"Myrtollari" }, + { + "forename":"E.", + "surname":"Calderini" + }, { "forename":"D.", "surname":"Kracher" }, { - "forename":"E.", - "surname":"Calderini" + "forename":"T.", + "surname":"Schongassner" + }, + { + "forename":"S.", + "surname":"Galusic" + }, + { + "forename":"A.", + "surname":"Slavica" + }, + { + "forename":"A.", + "surname":"Taden" }, { "forename":"D.", @@ -576350,7 +578630,7 @@ }, { "forename":"A.", - "surname":"Schruefer" + "surname":"Schrufer" }, { "forename":"G.", @@ -576378,26 +578658,129 @@ ], "subtitle":"Structure of the reconstructed ancestor of phenolic acid decarboxylase ancpad55", "tags":[ + "lyase", "phenolic acid decarboxylase", "ancestral sequence reconstruction", - "ancestor", - "lyase" + "ancestor" ], "keywords":[ - "description", - "found" + "organic", + "hydrophobic", + "structural", + "key", + "number", + "thermostable", + "reduce", + "three", + "hydroxycinnamic", + "acid", + "regression", + "candidates", + "study", + "accumulation", + "salt", + "stabilization", + "unfolding", + "predicting", + "straightforward", + "systems", + "crystal", + "stable", + "total", + "aqueous", + "deep", + "phenolic", + "proficient", + "experimentally", + "access", + "pool", + "selected", + "thus", + "bridges", + "gives", + "solvents", + "eutectic", + "thermal", + "makes", + "stability", + "approach", + "waste", + "calculated", + "proteins", + "achieved", + "process", + "ancestral", + "enzymes", + "hydrogen", + "enzyme", + "option", + "adhesive", + "biocatalyst", + "set", + "increase", + "surface", + "energy", + "biphasic", + "fit", + "used", + "feature", + "natural", + "yet", + "different", + "clusters", + "16", + "properties", + "application", + "variant", + "bonds", + "enhancing", + "turnover", + "explored", + "industrial", + "resulted", + "ancestors", + "buffers", + "time", + "applied", + "sequence", + "associated", + "production", + "consumption", + "models", + "h", + "identification", + "variants", + "structures", + "reconstruction", + "mixtures", + "enzymatic", + "styrenes", + "rely", + "determined", + "temperature", + "would", + "investigation", + "identify", + "45", + "decarboxylation", + "attributes", + "60", + "acids", + "decarboxylases", + "biobased", + "generate" ], "release_date":"2023-08-02", - "publication":"To be published", + "publication":"\"Stability Increase of Phenolic Acid Decarboxylase by a Combination of Protein and Solvent Engineering Unlocks Applications at Elevated Temperatures\", Acs Sustain Chem Eng, 12, 3575-3584", "publication_ref":{ - "DOI":"", - "PubMed":"", + "DOI":"10.1021\/acssuschemeng.3c06513", + "PubMed":"38456190", "CSD":"", - "ISSN":"", + "ISSN":"2168-0485", "ASTM":"" }, - "publication_country":"", - "abstract":"No description found.", + "publication_country":"US", + "abstract":"Enzymatic decarboxylation of biobased hydroxycinnamic acids gives access to phenolic styrenes for adhesive production. Phenolic acid decarboxylases are proficient enzymes that have been applied in aqueous systems, organic solvents, biphasic systems, and deep eutectic solvents, which makes stability a key feature. Stabilization of the enzyme would increase the total turnover number and thus reduce the energy consumption and waste accumulation associated with biocatalyst production. In this study, we used ancestral sequence reconstruction to generate thermostable decarboxylases. Investigation of a set of 16 ancestors resulted in the identification of a variant with an unfolding temperature of 78.1 \u00b0C and a half-life time of 45 h at 60 \u00b0C. Crystal structures were determined for three selected ancestors. Structural attributes were calculated to fit different regression models for predicting the thermal stability of variants that have not yet been experimentally explored. The models rely on hydrophobic clusters, salt bridges, hydrogen bonds, and surface properties and can identify more stable proteins out of a pool of candidates. Further stabilization was achieved by the application of mixtures of natural deep eutectic solvents and buffers. Our approach is a straightforward option for enhancing the industrial application of the decarboxylation process.", "crystal_structure":{ "length_a":"57.737", "length_b":"104.847", @@ -576426,19 +578809,19 @@ }, { "sim":51.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":51.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":51.0, - "partner":"8w08" + "partner":"8w06" }, { "sim":51.0, - "partner":"8w05" + "partner":"8v0a" }, { "sim":50.0, @@ -576508,28 +578891,12 @@ }, { "sim":58.0, - "partner":"4wya" - }, - { - "sim":58.0, - "partner":"4wyf" - }, - { - "sim":58.0, - "partner":"4cxq" - }, - { - "sim":58.0, - "partner":"5kgs" + "partner":"4cxr" }, { "sim":58.0, "partner":"4wyg" }, - { - "sim":58.0, - "partner":"4cxr" - }, { "sim":58.0, "partner":"4xjl" @@ -576594,25 +578961,33 @@ "sim":58.0, "partner":"3tfu" }, + { + "sim":58.0, + "partner":"4wya" + }, { "sim":58.0, "partner":"4wye" }, { - "sim":57.0, - "partner":"7p4y" + "sim":58.0, + "partner":"4wyf" }, { - "sim":57.0, - "partner":"7p50" + "sim":58.0, + "partner":"4cxq" + }, + { + "sim":58.0, + "partner":"5kgs" }, { "sim":57.0, - "partner":"5y0f" + "partner":"7p50" }, { "sim":57.0, - "partner":"5y0g" + "partner":"7p4y" }, { "sim":57.0, @@ -576624,27 +578999,27 @@ }, { "sim":57.0, - "partner":"5y12" + "partner":"6ljs" }, { "sim":57.0, - "partner":"6ljs" + "partner":"6ljt" }, { "sim":57.0, - "partner":"5d45" + "partner":"5y12" }, { "sim":57.0, - "partner":"5y13" + "partner":"6lju" }, { "sim":57.0, - "partner":"6ljt" + "partner":"5d45" }, { "sim":57.0, - "partner":"6lju" + "partner":"5y13" }, { "sim":57.0, @@ -576674,6 +579049,14 @@ "sim":57.0, "partner":"5y0x" }, + { + "sim":57.0, + "partner":"5y0f" + }, + { + "sim":57.0, + "partner":"5y0g" + }, { "sim":57.0, "partner":"4urs" @@ -576756,16 +579139,12 @@ }, { "sim":56.0, - "partner":"5uw0" + "partner":"5uw1" }, { "sim":56.0, "partner":"5vnc" }, - { - "sim":56.0, - "partner":"5uw1" - }, { "sim":56.0, "partner":"5uw4" @@ -576776,7 +579155,7 @@ }, { "sim":56.0, - "partner":"3rsz" + "partner":"5uw0" }, { "sim":56.0, @@ -576808,35 +579187,39 @@ }, { "sim":56.0, - "partner":"3ahc" + "partner":"3rsz" }, { "sim":56.0, - "partner":"3ahd" + "partner":"3ahf" }, { "sim":56.0, - "partner":"3ahe" + "partner":"3ahg" }, { "sim":56.0, - "partner":"3ahf" + "partner":"3ahh" }, { "sim":56.0, - "partner":"3ahg" + "partner":"3ahi" }, { "sim":56.0, - "partner":"3ahh" + "partner":"3ahj" }, { "sim":56.0, - "partner":"3ahi" + "partner":"3ahc" }, { "sim":56.0, - "partner":"3ahj" + "partner":"3ahd" + }, + { + "sim":56.0, + "partner":"3ahe" }, { "sim":55.0, @@ -576848,11 +579231,11 @@ }, { "sim":55.0, - "partner":"1wc6" + "partner":"1wc1" }, { "sim":55.0, - "partner":"1wc1" + "partner":"1wc6" }, { "sim":55.0, @@ -576896,11 +579279,11 @@ }, { "sim":55.0, - "partner":"8hsv" + "partner":"8hst" }, { "sim":55.0, - "partner":"8hst" + "partner":"8hsv" }, { "sim":55.0, @@ -577030,10 +579413,6 @@ "sim":54.0, "partner":"4nec" }, - { - "sim":54.0, - "partner":"5nbp" - }, { "sim":54.0, "partner":"7kr6" @@ -577046,6 +579425,10 @@ "sim":54.0, "partner":"5nbo" }, + { + "sim":54.0, + "partner":"5nbp" + }, { "sim":54.0, "partner":"8arv" @@ -577082,10 +579465,6 @@ "sim":54.0, "partner":"2b4u" }, - { - "sim":54.0, - "partner":"2pt0" - }, { "sim":54.0, "partner":"3d1o" @@ -577108,11 +579487,11 @@ }, { "sim":54.0, - "partner":"4ot7" + "partner":"2pt0" }, { "sim":54.0, - "partner":"6put" + "partner":"4ot7" }, { "sim":54.0, @@ -577126,13 +579505,17 @@ "sim":54.0, "partner":"6v3k" }, + { + "sim":54.0, + "partner":"6puz" + }, { "sim":54.0, "partner":"5u1c" }, { "sim":54.0, - "partner":"6puz" + "partner":"6put" }, { "sim":54.0, @@ -577176,11 +579559,11 @@ }, { "sim":53.0, - "partner":"7u0u" + "partner":"7d7d" }, { "sim":53.0, - "partner":"7d7d" + "partner":"7u0u" }, { "sim":53.0, @@ -577270,10 +579653,6 @@ "sim":53.0, "partner":"2f17" }, - { - "sim":53.0, - "partner":"4yvk" - }, { "sim":53.0, "partner":"8apt" @@ -577316,7 +579695,7 @@ }, { "sim":53.0, - "partner":"4jyi" + "partner":"4yvk" }, { "sim":53.0, @@ -577342,6 +579721,10 @@ "sim":53.0, "partner":"4jyh" }, + { + "sim":53.0, + "partner":"4jyi" + }, { "sim":53.0, "partner":"6szg" @@ -577442,10 +579825,6 @@ "sim":53.0, "partner":"4s2c" }, - { - "sim":53.0, - "partner":"4d2w" - }, { "sim":53.0, "partner":"4d2p" @@ -577478,6 +579857,10 @@ "sim":53.0, "partner":"4d2v" }, + { + "sim":53.0, + "partner":"4d2w" + }, { "sim":53.0, "partner":"4hty" @@ -577494,10 +579877,6 @@ "sim":53.0, "partner":"7qwt" }, - { - "sim":53.0, - "partner":"3pz9" - }, { "sim":53.0, "partner":"3pzg" @@ -577524,7 +579903,7 @@ }, { "sim":53.0, - "partner":"5hxu" + "partner":"3pz9" }, { "sim":53.0, @@ -577538,6 +579917,10 @@ "sim":53.0, "partner":"5hwe" }, + { + "sim":53.0, + "partner":"5hxu" + }, { "sim":53.0, "partner":"3vax" @@ -577620,79 +580003,79 @@ }, { "sim":53.0, - "partner":"8gf0" + "partner":"7lam" }, { "sim":53.0, - "partner":"8gfp" + "partner":"8gfb" }, { "sim":53.0, - "partner":"8gf1" + "partner":"8gfc" }, { "sim":53.0, - "partner":"8gfq" + "partner":"8gfd" }, { "sim":53.0, - "partner":"8gfs" + "partner":"8gfe" }, { "sim":53.0, - "partner":"7lam" + "partner":"7laq" }, { "sim":53.0, - "partner":"7laq" + "partner":"8gff" }, { "sim":53.0, - "partner":"8gfb" + "partner":"8gfg" }, { "sim":53.0, - "partner":"8gfc" + "partner":"8gfh" }, { "sim":53.0, - "partner":"8gfd" + "partner":"8gfi" }, { "sim":53.0, - "partner":"8gfe" + "partner":"8gfj" }, { "sim":53.0, - "partner":"8gff" + "partner":"8gfl" }, { "sim":53.0, - "partner":"8gfg" + "partner":"8gfm" }, { "sim":53.0, - "partner":"8gfh" + "partner":"8gez" }, { "sim":53.0, - "partner":"8gfi" + "partner":"8gf0" }, { "sim":53.0, - "partner":"8gfj" + "partner":"8gfp" }, { "sim":53.0, - "partner":"8gfl" + "partner":"8gf1" }, { "sim":53.0, - "partner":"8gfm" + "partner":"8gfq" }, { "sim":53.0, - "partner":"8gez" + "partner":"8gfs" }, { "sim":53.0, @@ -577710,10 +580093,6 @@ "sim":53.0, "partner":"7bn9" }, - { - "sim":53.0, - "partner":"6yt0" - }, { "sim":53.0, "partner":"4zhj" @@ -577730,6 +580109,10 @@ "sim":53.0, "partner":"6ytj" }, + { + "sim":53.0, + "partner":"6yt0" + }, { "sim":52.0, "partner":"1yww" @@ -577806,10 +580189,6 @@ "sim":52.0, "partner":"4qxz" }, - { - "sim":52.0, - "partner":"5c7p" - }, { "sim":52.0, "partner":"7f0y" @@ -577826,6 +580205,10 @@ "sim":52.0, "partner":"7f11" }, + { + "sim":52.0, + "partner":"5c7p" + }, { "sim":52.0, "partner":"7ckv" @@ -577964,11 +580347,11 @@ }, { "sim":52.0, - "partner":"4fq7" + "partner":"4fq5" }, { "sim":52.0, - "partner":"4fq5" + "partner":"4fq7" }, { "sim":52.0, @@ -577990,10 +580373,6 @@ "sim":52.0, "partner":"3u3j" }, - { - "sim":52.0, - "partner":"3u3r" - }, { "sim":52.0, "partner":"3u3k" @@ -578006,25 +580385,29 @@ "sim":52.0, "partner":"3u3o" }, + { + "sim":52.0, + "partner":"3u3r" + }, { "sim":52.0, "partner":"3utn" }, { "sim":52.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":52.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":52.0, - "partner":"3tm8" + "partner":"3tmc" }, { "sim":52.0, - "partner":"3tmb" + "partner":"3tmd" }, { "sim":52.0, @@ -578036,11 +580419,11 @@ }, { "sim":52.0, - "partner":"7js3" + "partner":"8g5w" }, { "sim":52.0, - "partner":"8g5w" + "partner":"7js3" }, { "sim":52.0, @@ -578056,7 +580439,7 @@ }, { "sim":52.0, - "partner":"6pi5" + "partner":"6pi6" }, { "sim":52.0, @@ -578064,7 +580447,7 @@ }, { "sim":52.0, - "partner":"6pi6" + "partner":"6pi5" }, { "sim":52.0, @@ -578126,10 +580509,6 @@ "sim":52.0, "partner":"4cqd" }, - { - "sim":52.0, - "partner":"5cu7" - }, { "sim":52.0, "partner":"4fdt" @@ -578144,15 +580523,19 @@ }, { "sim":52.0, - "partner":"6v99" + "partner":"5cu7" }, { "sim":52.0, - "partner":"6v9a" + "partner":"6v96" }, { "sim":52.0, - "partner":"6v96" + "partner":"6v99" + }, + { + "sim":52.0, + "partner":"6v9a" }, { "sim":52.0, @@ -578224,15 +580607,15 @@ }, { "sim":52.0, - "partner":"7an1" + "partner":"7oqd" }, { "sim":52.0, - "partner":"7oqd" + "partner":"2x50" }, { "sim":52.0, - "partner":"2x50" + "partner":"7an1" }, { "sim":52.0, @@ -578268,15 +580651,15 @@ }, { "sim":52.0, - "partner":"5kdn" + "partner":"5kds" }, { "sim":52.0, - "partner":"5kds" + "partner":"5kdu" }, { "sim":52.0, - "partner":"5kdu" + "partner":"5kdn" }, { "sim":52.0, @@ -578302,10 +580685,6 @@ "sim":52.0, "partner":"6dqx" }, - { - "sim":52.0, - "partner":"7tgl" - }, { "sim":52.0, "partner":"7tgm" @@ -578318,6 +580697,10 @@ "sim":52.0, "partner":"7tgk" }, + { + "sim":52.0, + "partner":"7tgl" + }, { "sim":52.0, "partner":"2o1u" @@ -578346,10 +580729,6 @@ "sim":52.0, "partner":"7ufu" }, - { - "sim":52.0, - "partner":"4xc6" - }, { "sim":52.0, "partner":"4xc7" @@ -578374,6 +580753,10 @@ "sim":52.0, "partner":"5cjw" }, + { + "sim":52.0, + "partner":"4xc6" + }, { "sim":52.0, "partner":"3va7" @@ -578408,11 +580791,11 @@ }, { "sim":51.0, - "partner":"5ho3" + "partner":"5ho1" }, { "sim":51.0, - "partner":"5ho1" + "partner":"5ho3" }, { "sim":51.0, @@ -578542,17 +580925,13 @@ "sim":51.0, "partner":"7ywg" }, - { - "sim":51.0, - "partner":"4kpc" - }, { "sim":51.0, "partner":"7f0z" }, { "sim":51.0, - "partner":"7xtl" + "partner":"4kpc" }, { "sim":51.0, @@ -578564,7 +580943,11 @@ }, { "sim":51.0, - "partner":"5edd" + "partner":"7xtl" + }, + { + "sim":51.0, + "partner":"8p8o" }, { "sim":51.0, @@ -578600,15 +580983,15 @@ }, { "sim":51.0, - "partner":"8p8o" + "partner":"1sm8" }, { "sim":51.0, - "partner":"1sm8" + "partner":"3hza" }, { "sim":51.0, - "partner":"3hza" + "partner":"5edd" }, { "sim":51.0, @@ -578654,14 +581037,6 @@ "sim":51.0, "partner":"7efx" }, - { - "sim":51.0, - "partner":"3jun" - }, - { - "sim":51.0, - "partner":"3juo" - }, { "sim":51.0, "partner":"3jup" @@ -578694,6 +581069,14 @@ "sim":51.0, "partner":"3jum" }, + { + "sim":51.0, + "partner":"3jun" + }, + { + "sim":51.0, + "partner":"3juo" + }, { "sim":51.0, "partner":"7l8k" @@ -578748,31 +581131,19 @@ }, { "sim":51.0, - "partner":"6vll" - }, - { - "sim":51.0, - "partner":"5wg9" - }, - { - "sim":51.0, - "partner":"6v53" - }, - { - "sim":51.0, - "partner":"8edz" + "partner":"5wap" }, { "sim":51.0, - "partner":"6wij" + "partner":"6v56" }, { "sim":51.0, - "partner":"8dvo" + "partner":"6whm" }, { "sim":51.0, - "partner":"5wap" + "partner":"7kop" }, { "sim":51.0, @@ -578780,23 +581151,15 @@ }, { "sim":51.0, - "partner":"6v56" - }, - { - "sim":51.0, - "partner":"6whm" - }, - { - "sim":51.0, - "partner":"7kop" + "partner":"6v9e" }, { "sim":51.0, - "partner":"5w7u" + "partner":"6vbr" }, { "sim":51.0, - "partner":"6v9e" + "partner":"6vg9" }, { "sim":51.0, @@ -578804,11 +581167,11 @@ }, { "sim":51.0, - "partner":"6vbr" + "partner":"8e21" }, { "sim":51.0, - "partner":"6vg9" + "partner":"5w7u" }, { "sim":51.0, @@ -578824,27 +581187,31 @@ }, { "sim":51.0, - "partner":"8e21" + "partner":"5wfw" }, { "sim":51.0, - "partner":"5wfw" + "partner":"8dqs" }, { "sim":51.0, "partner":"5deb" }, + { + "sim":51.0, + "partner":"7kbc" + }, { "sim":51.0, "partner":"5dbs" }, { "sim":51.0, - "partner":"7kbc" + "partner":"6v6x" }, { "sim":51.0, - "partner":"5w9g" + "partner":"6vjh" }, { "sim":51.0, @@ -578852,35 +581219,35 @@ }, { "sim":51.0, - "partner":"8dqs" + "partner":"8dpj" }, { "sim":51.0, - "partner":"5vqn" + "partner":"8dtw" }, { "sim":51.0, - "partner":"5wdw" + "partner":"5w9g" }, { "sim":51.0, - "partner":"5wfz" + "partner":"7kny" }, { "sim":51.0, - "partner":"6v6x" + "partner":"7lp8" }, { "sim":51.0, - "partner":"6vjh" + "partner":"5vqn" }, { "sim":51.0, - "partner":"7kny" + "partner":"5wdw" }, { "sim":51.0, - "partner":"7lp8" + "partner":"5wfz" }, { "sim":51.0, @@ -578888,15 +581255,15 @@ }, { "sim":51.0, - "partner":"8dpj" + "partner":"8e1q" }, { "sim":51.0, - "partner":"8dtw" + "partner":"7uuh" }, { "sim":51.0, - "partner":"7uuh" + "partner":"7lm4" }, { "sim":51.0, @@ -578912,15 +581279,11 @@ }, { "sim":51.0, - "partner":"7lm4" - }, - { - "sim":51.0, - "partner":"8e1q" + "partner":"6vl3" }, { "sim":51.0, - "partner":"5vpt" + "partner":"6w7a" }, { "sim":51.0, @@ -578928,11 +581291,11 @@ }, { "sim":51.0, - "partner":"6vl3" + "partner":"8e4s" }, { "sim":51.0, - "partner":"6w7a" + "partner":"5vpt" }, { "sim":51.0, @@ -578940,27 +581303,27 @@ }, { "sim":51.0, - "partner":"5vp8" + "partner":"7k87" }, { "sim":51.0, - "partner":"5w92" + "partner":"7n47" }, { "sim":51.0, - "partner":"5wa6" + "partner":"5vp8" }, { "sim":51.0, - "partner":"7k87" + "partner":"5w92" }, { "sim":51.0, - "partner":"7n47" + "partner":"5wa6" }, { "sim":51.0, - "partner":"8e4s" + "partner":"8dip" }, { "sim":51.0, @@ -578976,7 +581339,7 @@ }, { "sim":51.0, - "partner":"5vrj" + "partner":"6wj4" }, { "sim":51.0, @@ -578984,11 +581347,11 @@ }, { "sim":51.0, - "partner":"8dip" + "partner":"5vrj" }, { "sim":51.0, - "partner":"6wj4" + "partner":"6ws3" }, { "sim":51.0, @@ -578996,7 +581359,7 @@ }, { "sim":51.0, - "partner":"6ws3" + "partner":"6viv" }, { "sim":51.0, @@ -579004,19 +581367,15 @@ }, { "sim":51.0, - "partner":"5w73" - }, - { - "sim":51.0, - "partner":"6viv" + "partner":"7k77" }, { "sim":51.0, - "partner":"7k77" + "partner":"7umr" }, { "sim":51.0, - "partner":"7umr" + "partner":"5w73" }, { "sim":51.0, @@ -579042,6 +581401,10 @@ "sim":51.0, "partner":"4r1j" }, + { + "sim":51.0, + "partner":"6vll" + }, { "sim":51.0, "partner":"7k0w" @@ -579050,6 +581413,26 @@ "sim":51.0, "partner":"7n55" }, + { + "sim":51.0, + "partner":"8edz" + }, + { + "sim":51.0, + "partner":"6v53" + }, + { + "sim":51.0, + "partner":"8dvo" + }, + { + "sim":51.0, + "partner":"6wij" + }, + { + "sim":51.0, + "partner":"5wg9" + }, { "sim":51.0, "partner":"6ede" @@ -579150,14 +581533,6 @@ "sim":51.0, "partner":"2ym0" }, - { - "sim":51.0, - "partner":"3nh1" - }, - { - "sim":51.0, - "partner":"3v9z" - }, { "sim":51.0, "partner":"3v9u" @@ -579210,6 +581585,14 @@ "sim":51.0, "partner":"3v9s" }, + { + "sim":51.0, + "partner":"3nh1" + }, + { + "sim":51.0, + "partner":"3v9z" + }, { "sim":51.0, "partner":"3nt7" @@ -579228,11 +581611,11 @@ }, { "sim":51.0, - "partner":"2ium" + "partner":"7qej" }, { "sim":51.0, - "partner":"7qej" + "partner":"2ium" }, { "sim":51.0, @@ -579244,11 +581627,11 @@ }, { "sim":51.0, - "partner":"4cnf" + "partner":"7aie" }, { "sim":51.0, - "partner":"7aie" + "partner":"4cnf" }, { "sim":51.0, @@ -579258,25 +581641,17 @@ "sim":51.0, "partner":"5oj8" }, - { - "sim":51.0, - "partner":"6ey1" - }, { "sim":51.0, "partner":"6f0w" }, { "sim":51.0, - "partner":"7wzg" - }, - { - "sim":51.0, - "partner":"4ke6" + "partner":"6ey1" }, { "sim":51.0, - "partner":"4m7t" + "partner":"7wzg" }, { "sim":51.0, @@ -579310,6 +581685,14 @@ "sim":51.0, "partner":"3rli" }, + { + "sim":51.0, + "partner":"4ke6" + }, + { + "sim":51.0, + "partner":"4m7t" + }, { "sim":51.0, "partner":"1l2j" @@ -579340,15 +581723,15 @@ }, { "sim":51.0, - "partner":"1zw3" + "partner":"1zvz" }, { "sim":51.0, - "partner":"1zvz" + "partner":"1zw2" }, { "sim":51.0, - "partner":"1zw2" + "partner":"1zw3" }, { "sim":51.0, @@ -579396,23 +581779,23 @@ }, { "sim":51.0, - "partner":"5lto" + "partner":"5lt9" }, { "sim":51.0, - "partner":"4q2g" + "partner":"1zct" }, { "sim":51.0, - "partner":"5lt9" + "partner":"4q2e" }, { "sim":51.0, - "partner":"1zct" + "partner":"5lto" }, { "sim":51.0, - "partner":"4q2e" + "partner":"4q2g" }, { "sim":51.0, @@ -579508,11 +581891,11 @@ }, { "sim":51.0, - "partner":"5lsg" + "partner":"6t9c" }, { "sim":51.0, - "partner":"6t9c" + "partner":"5lsg" }, { "sim":51.0, @@ -579532,19 +581915,15 @@ }, { "sim":51.0, - "partner":"2oau" - }, - { - "sim":51.0, - "partner":"4hwa" + "partner":"6uzh" }, { "sim":51.0, - "partner":"6uzh" + "partner":"2oau" }, { "sim":51.0, - "partner":"3s3h" + "partner":"4hwa" }, { "sim":51.0, @@ -579558,6 +581937,10 @@ "sim":51.0, "partner":"3s3f" }, + { + "sim":51.0, + "partner":"3s3h" + }, { "sim":51.0, "partner":"2zni" @@ -579626,10 +582009,6 @@ "sim":51.0, "partner":"6k92" }, - { - "sim":51.0, - "partner":"3aio" - }, { "sim":51.0, "partner":"3aik" @@ -579648,15 +582027,11 @@ }, { "sim":51.0, - "partner":"4xrw" - }, - { - "sim":51.0, - "partner":"5exi" + "partner":"3aio" }, { "sim":51.0, - "partner":"5exj" + "partner":"4xrw" }, { "sim":51.0, @@ -579664,23 +582039,23 @@ }, { "sim":51.0, - "partner":"3h7u" + "partner":"5exi" }, { "sim":51.0, - "partner":"6asv" + "partner":"5exj" }, { "sim":51.0, - "partner":"7cgv" + "partner":"3h7u" }, { "sim":51.0, - "partner":"5tyq" + "partner":"6asv" }, { "sim":51.0, - "partner":"5u19" + "partner":"7cgv" }, { "sim":51.0, @@ -579700,31 +582075,31 @@ }, { "sim":51.0, - "partner":"7q4u" + "partner":"5tyq" }, { "sim":51.0, - "partner":"7q59" + "partner":"5u19" }, { "sim":51.0, - "partner":"7pp4" + "partner":"7zf2" }, { "sim":51.0, - "partner":"7zf2" + "partner":"7q4u" }, { "sim":51.0, - "partner":"5m8e" + "partner":"7q59" }, { "sim":51.0, - "partner":"4h2w" + "partner":"7pp4" }, { "sim":51.0, - "partner":"3mey" + "partner":"5m8e" }, { "sim":51.0, @@ -579782,6 +582157,14 @@ "sim":51.0, "partner":"4h2v" }, + { + "sim":51.0, + "partner":"4h2w" + }, + { + "sim":51.0, + "partner":"3mey" + }, { "sim":51.0, "partner":"2pvh" @@ -579844,67 +582227,67 @@ }, { "sim":51.0, - "partner":"4m25" + "partner":"4m26" }, { "sim":51.0, - "partner":"4m2i" + "partner":"4m27" }, { "sim":51.0, - "partner":"4ne0" + "partner":"6clw" }, { "sim":51.0, - "partner":"4m26" + "partner":"6clx" }, { "sim":51.0, - "partner":"4m27" + "partner":"4m2c" }, { "sim":51.0, - "partner":"6clw" + "partner":"6ems" }, { "sim":51.0, - "partner":"6clx" + "partner":"6xn0" }, { "sim":51.0, - "partner":"4m2c" + "partner":"4m2e" }, { "sim":51.0, - "partner":"4m2e" + "partner":"6xn1" }, { "sim":51.0, - "partner":"6ems" + "partner":"6xn2" }, { "sim":51.0, - "partner":"6xn0" + "partner":"4m2f" }, { "sim":51.0, - "partner":"6xn1" + "partner":"4m23" }, { "sim":51.0, - "partner":"4m2f" + "partner":"4m2g" }, { "sim":51.0, - "partner":"6xn2" + "partner":"4m25" }, { "sim":51.0, - "partner":"4m23" + "partner":"4m2i" }, { "sim":51.0, - "partner":"4m2g" + "partner":"4ne0" }, { "sim":51.0, @@ -579970,10 +582353,6 @@ "sim":51.0, "partner":"3a16" }, - { - "sim":51.0, - "partner":"2iua" - }, { "sim":51.0, "partner":"2iu8" @@ -579984,15 +582363,15 @@ }, { "sim":51.0, - "partner":"5hjn" + "partner":"2iua" }, { "sim":51.0, - "partner":"5hjq" + "partner":"5hjn" }, { "sim":51.0, - "partner":"3c1y" + "partner":"5hjq" }, { "sim":51.0, @@ -580044,23 +582423,23 @@ }, { "sim":51.0, - "partner":"2yjn" + "partner":"3c1y" }, { "sim":51.0, - "partner":"4ltz" + "partner":"2yjn" }, { "sim":51.0, - "partner":"7kj8" + "partner":"3kbk" }, { "sim":51.0, - "partner":"7kj9" + "partner":"6ax9" }, { "sim":51.0, - "partner":"3kbk" + "partner":"7kjd" }, { "sim":51.0, @@ -580068,7 +582447,7 @@ }, { "sim":51.0, - "partner":"6ax9" + "partner":"7kje" }, { "sim":51.0, @@ -580076,43 +582455,35 @@ }, { "sim":51.0, - "partner":"8su2" - }, - { - "sim":51.0, - "partner":"8su3" - }, - { - "sim":51.0, - "partner":"7kjd" + "partner":"6axu" }, { "sim":51.0, - "partner":"8su4" + "partner":"7kjf" }, { "sim":51.0, - "partner":"6axu" + "partner":"8su2" }, { "sim":51.0, - "partner":"7kje" + "partner":"7kjg" }, { "sim":51.0, - "partner":"8su5" + "partner":"8su3" }, { "sim":51.0, - "partner":"7kjf" + "partner":"8su4" }, { "sim":51.0, - "partner":"7kjg" + "partner":"4lxw" }, { "sim":51.0, - "partner":"4lxw" + "partner":"8su5" }, { "sim":51.0, @@ -580156,11 +582527,19 @@ }, { "sim":51.0, - "partner":"4dn1" + "partner":"7kj8" }, { "sim":51.0, - "partner":"2gqn" + "partner":"4ltz" + }, + { + "sim":51.0, + "partner":"7kj9" + }, + { + "sim":51.0, + "partner":"4dn1" }, { "sim":51.0, @@ -580186,10 +582565,18 @@ "sim":51.0, "partner":"2fq6" }, + { + "sim":51.0, + "partner":"2gqn" + }, { "sim":51.0, "partner":"5xpj" }, + { + "sim":51.0, + "partner":"8s53" + }, { "sim":51.0, "partner":"6j82" @@ -580208,35 +582595,35 @@ }, { "sim":51.0, - "partner":"5dvi" + "partner":"4e2p" }, { "sim":51.0, - "partner":"5xw2" + "partner":"5dvj" }, { "sim":51.0, - "partner":"5dvj" + "partner":"3ssm" }, { "sim":51.0, - "partner":"4e2p" + "partner":"3ssn" }, { "sim":51.0, - "partner":"3ssm" + "partner":"3sso" }, { "sim":51.0, - "partner":"3ssn" + "partner":"5dvf" }, { "sim":51.0, - "partner":"3sso" + "partner":"5dvi" }, { "sim":51.0, - "partner":"5dvf" + "partner":"5xw2" }, { "sim":51.0, @@ -580260,11 +582647,11 @@ }, { "sim":51.0, - "partner":"4pk6" + "partner":"6r63" }, { "sim":51.0, - "partner":"6r63" + "partner":"4pk6" }, { "sim":51.0, @@ -580290,21 +582677,17 @@ "sim":51.0, "partner":"2gqd" }, - { - "sim":51.0, - "partner":"7cqq" - }, { "sim":51.0, "partner":"7cqu" }, { "sim":51.0, - "partner":"2o1t" + "partner":"7cqw" }, { "sim":51.0, - "partner":"7cqw" + "partner":"2o1t" }, { "sim":51.0, @@ -580318,6 +582701,10 @@ "sim":51.0, "partner":"7cqn" }, + { + "sim":51.0, + "partner":"7cqq" + }, { "sim":51.0, "partner":"2z67" @@ -580332,23 +582719,23 @@ }, { "sim":51.0, - "partner":"4gt2" + "partner":"4ach" }, { "sim":51.0, - "partner":"4acg" + "partner":"4acc" }, { "sim":51.0, - "partner":"4ach" + "partner":"4acd" }, { "sim":51.0, - "partner":"4acc" + "partner":"4gt2" }, { "sim":51.0, - "partner":"4acd" + "partner":"4acg" }, { "sim":51.0, @@ -580356,19 +582743,19 @@ }, { "sim":51.0, - "partner":"2gps" + "partner":"6jjo" }, { "sim":51.0, - "partner":"6jjo" + "partner":"2gpw" }, { "sim":51.0, - "partner":"6oi9" + "partner":"2gps" }, { "sim":51.0, - "partner":"2gpw" + "partner":"6oi9" }, { "sim":51.0, @@ -580376,15 +582763,15 @@ }, { "sim":51.0, - "partner":"4l2h" + "partner":"4epp" }, { "sim":51.0, - "partner":"4epp" + "partner":"4epq" }, { "sim":51.0, - "partner":"4epq" + "partner":"4l2h" }, { "sim":51.0, @@ -580472,15 +582859,15 @@ }, { "sim":51.0, - "partner":"6x0h" + "partner":"6x0j" }, { "sim":51.0, - "partner":"6x0j" + "partner":"6x0k" }, { "sim":51.0, - "partner":"6x0k" + "partner":"6x0h" }, { "sim":51.0, @@ -580566,10 +582953,6 @@ "sim":51.0, "partner":"6l4o" }, - { - "sim":51.0, - "partner":"5wm2" - }, { "sim":51.0, "partner":"5wm3" @@ -580592,19 +582975,19 @@ }, { "sim":51.0, - "partner":"7xsf" + "partner":"5wm2" }, { "sim":51.0, - "partner":"3rde" + "partner":"7xsf" }, { "sim":51.0, - "partner":"6j1f" + "partner":"3rde" }, { "sim":51.0, - "partner":"6j1e" + "partner":"6j1f" }, { "sim":51.0, @@ -580622,6 +583005,10 @@ "sim":51.0, "partner":"6j0p" }, + { + "sim":51.0, + "partner":"6j1e" + }, { "sim":51.0, "partner":"2wmi" @@ -580684,43 +583071,43 @@ }, { "sim":51.0, - "partner":"2yii" + "partner":"4c5u" }, { "sim":51.0, - "partner":"4c5s" + "partner":"4cq5" }, { "sim":51.0, - "partner":"4v2r" + "partner":"4baa" }, { "sim":51.0, - "partner":"4c5u" + "partner":"4c6g" }, { "sim":51.0, - "partner":"4cq5" + "partner":"4bab" }, { "sim":51.0, - "partner":"4baa" + "partner":"4c5r" }, { "sim":51.0, - "partner":"4c6g" + "partner":"2yii" }, { "sim":51.0, - "partner":"4bab" + "partner":"4v2q" }, { "sim":51.0, - "partner":"4c5r" + "partner":"4c5s" }, { "sim":51.0, - "partner":"4v2q" + "partner":"4v2r" }, { "sim":51.0, @@ -580742,10 +583129,6 @@ "sim":51.0, "partner":"5jrl" }, - { - "sim":51.0, - "partner":"7wlg" - }, { "sim":51.0, "partner":"7wj9" @@ -580774,6 +583157,10 @@ "sim":51.0, "partner":"7wjf" }, + { + "sim":51.0, + "partner":"7wlg" + }, { "sim":51.0, "partner":"5ayk" @@ -580808,15 +583195,15 @@ }, { "sim":51.0, - "partner":"7o3m" + "partner":"7o3n" }, { "sim":51.0, - "partner":"7o3n" + "partner":"7o3l" }, { "sim":51.0, - "partner":"7o3l" + "partner":"7o3m" }, { "sim":51.0, @@ -580840,11 +583227,11 @@ }, { "sim":50.0, - "partner":"6iva" + "partner":"6iww" }, { "sim":50.0, - "partner":"6iww" + "partner":"6iva" }, { "sim":50.0, @@ -580892,11 +583279,11 @@ }, { "sim":50.0, - "partner":"2jop" + "partner":"1nyn" }, { "sim":50.0, - "partner":"1nyn" + "partner":"2jop" }, { "sim":50.0, @@ -580948,15 +583335,15 @@ }, { "sim":50.0, - "partner":"4ozj" + "partner":"4ozn" }, { "sim":50.0, - "partner":"4ozl" + "partner":"4ozj" }, { "sim":50.0, - "partner":"4ozn" + "partner":"4ozl" }, { "sim":50.0, @@ -580986,10 +583373,6 @@ "sim":50.0, "partner":"2bze" }, - { - "sim":50.0, - "partner":"5wqi" - }, { "sim":50.0, "partner":"6ecy" @@ -581022,6 +583405,10 @@ "sim":50.0, "partner":"4lfm" }, + { + "sim":50.0, + "partner":"5wqi" + }, { "sim":50.0, "partner":"4lfn" @@ -581138,10 +583525,6 @@ "sim":50.0, "partner":"5b4n" }, - { - "sim":50.0, - "partner":"3th5" - }, { "sim":50.0, "partner":"4gzl" @@ -581164,15 +583547,11 @@ }, { "sim":50.0, - "partner":"3p6b" - }, - { - "sim":50.0, - "partner":"3l1u" + "partner":"3th5" }, { "sim":50.0, - "partner":"6pj9" + "partner":"3p6b" }, { "sim":50.0, @@ -581180,11 +583559,11 @@ }, { "sim":50.0, - "partner":"6pja" + "partner":"6pjp" }, { "sim":50.0, - "partner":"6pjp" + "partner":"6pjq" }, { "sim":50.0, @@ -581192,11 +583571,11 @@ }, { "sim":50.0, - "partner":"6pjq" + "partner":"6pjr" }, { "sim":50.0, - "partner":"6pjr" + "partner":"6pju" }, { "sim":50.0, @@ -581210,10 +583589,6 @@ "sim":50.0, "partner":"2gmw" }, - { - "sim":50.0, - "partner":"6pju" - }, { "sim":50.0, "partner":"4njp" @@ -581244,15 +583619,19 @@ }, { "sim":50.0, - "partner":"5f5j" + "partner":"6pj5" }, { "sim":50.0, - "partner":"6pj5" + "partner":"6pj7" }, { "sim":50.0, - "partner":"6pj7" + "partner":"5f5j" + }, + { + "sim":50.0, + "partner":"6pj8" }, { "sim":50.0, @@ -581260,7 +583639,15 @@ }, { "sim":50.0, - "partner":"6pj8" + "partner":"6pj9" + }, + { + "sim":50.0, + "partner":"3l1u" + }, + { + "sim":50.0, + "partner":"6pja" }, { "sim":50.0, @@ -581280,7 +583667,7 @@ }, { "sim":50.0, - "partner":"7fe0" + "partner":"7fe5" }, { "sim":50.0, @@ -581288,16 +583675,12 @@ }, { "sim":50.0, - "partner":"7fe5" + "partner":"7fe0" }, { "sim":50.0, "partner":"3eik" }, - { - "sim":50.0, - "partner":"6a98" - }, { "sim":50.0, "partner":"6a99" @@ -581310,6 +583693,10 @@ "sim":50.0, "partner":"6a9f" }, + { + "sim":50.0, + "partner":"6a98" + }, { "sim":50.0, "partner":"2xdu" @@ -581362,14 +583749,6 @@ "sim":50.0, "partner":"5ejl" }, - { - "sim":50.0, - "partner":"3ft5" - }, - { - "sim":50.0, - "partner":"2xdx" - }, { "sim":50.0, "partner":"3ft8" @@ -581438,6 +583817,14 @@ "sim":50.0, "partner":"2xhx" }, + { + "sim":50.0, + "partner":"3ft5" + }, + { + "sim":50.0, + "partner":"2xdx" + }, { "sim":50.0, "partner":"2ho1" @@ -581510,14 +583897,6 @@ "sim":50.0, "partner":"5c12" }, - { - "sim":50.0, - "partner":"6hxo" - }, - { - "sim":50.0, - "partner":"3dbp" - }, { "sim":50.0, "partner":"3mo7" @@ -581540,27 +583919,27 @@ }, { "sim":50.0, - "partner":"5vrc" + "partner":"6hxo" }, { "sim":50.0, - "partner":"6akv" + "partner":"3dbp" }, { "sim":50.0, - "partner":"6l8u" + "partner":"5vrc" }, { "sim":50.0, - "partner":"6wyi" + "partner":"6akv" }, { "sim":50.0, - "partner":"3quo" + "partner":"6l8u" }, { "sim":50.0, - "partner":"3qvf" + "partner":"6wyi" }, { "sim":50.0, @@ -581582,6 +583961,14 @@ "sim":50.0, "partner":"3qun" }, + { + "sim":50.0, + "partner":"3quo" + }, + { + "sim":50.0, + "partner":"3qvf" + }, { "sim":50.0, "partner":"3jyy" @@ -581612,11 +583999,11 @@ }, { "sim":50.0, - "partner":"4rdh" + "partner":"4rdi" }, { "sim":50.0, - "partner":"4rdi" + "partner":"4rdh" }, { "sim":50.0, @@ -581666,10 +584053,6 @@ "sim":50.0, "partner":"8r2x" }, - { - "sim":50.0, - "partner":"4pgc" - }, { "sim":50.0, "partner":"4pgd" @@ -581688,7 +584071,7 @@ }, { "sim":50.0, - "partner":"5uto" + "partner":"4pgc" }, { "sim":50.0, @@ -581696,12 +584079,16 @@ }, { "sim":50.0, - "partner":"6y5x" + "partner":"5uto" }, { "sim":50.0, "partner":"6y5y" }, + { + "sim":50.0, + "partner":"6y5x" + }, { "sim":50.0, "partner":"6cl4" @@ -581780,51 +584167,51 @@ }, { "sim":50.0, - "partner":"6cwo" + "partner":"3pdc" }, { "sim":50.0, - "partner":"3pdc" + "partner":"6cwo" }, { "sim":50.0, - "partner":"3sie" + "partner":"4i9z" }, { "sim":50.0, - "partner":"4g2w" + "partner":"4ia0" }, { "sim":50.0, - "partner":"4g2y" + "partner":"4oew" }, { "sim":50.0, - "partner":"4i9z" + "partner":"4oex" }, { "sim":50.0, - "partner":"4ia0" + "partner":"6iwi" }, { "sim":50.0, - "partner":"4oew" + "partner":"3shy" }, { "sim":50.0, - "partner":"4oex" + "partner":"3shz" }, { "sim":50.0, - "partner":"6iwi" + "partner":"3sie" }, { "sim":50.0, - "partner":"3shy" + "partner":"4g2w" }, { "sim":50.0, - "partner":"3shz" + "partner":"4g2y" }, { "sim":50.0, @@ -581922,10 +584309,6 @@ "sim":50.0, "partner":"5zyb" }, - { - "sim":50.0, - "partner":"7azd" - }, { "sim":50.0, "partner":"7az5" @@ -581956,23 +584339,27 @@ }, { "sim":50.0, - "partner":"5x06" + "partner":"7azg" }, { "sim":50.0, - "partner":"7azg" + "partner":"5x06" }, { "sim":50.0, "partner":"7azc" }, + { + "sim":50.0, + "partner":"7azd" + }, { "sim":50.0, "partner":"4xau" }, { "sim":50.0, - "partner":"6kjh" + "partner":"6y9d" }, { "sim":50.0, @@ -581980,39 +584367,39 @@ }, { "sim":50.0, - "partner":"6y8j" + "partner":"6kjp" }, { "sim":50.0, - "partner":"6y9c" + "partner":"6kjq" }, { "sim":50.0, - "partner":"6y9d" + "partner":"6kjr" }, { "sim":50.0, - "partner":"6kjj" + "partner":"6kjt" }, { "sim":50.0, - "partner":"6kjp" + "partner":"6y8s" }, { "sim":50.0, - "partner":"6kjq" + "partner":"6kjh" }, { "sim":50.0, - "partner":"6kjr" + "partner":"6y8j" }, { "sim":50.0, - "partner":"6kjt" + "partner":"6y9c" }, { "sim":50.0, - "partner":"6y8s" + "partner":"6kjj" }, { "sim":50.0, @@ -582028,15 +584415,15 @@ }, { "sim":50.0, - "partner":"6s0g" + "partner":"7bn6" }, { "sim":50.0, - "partner":"7bn6" + "partner":"6s23" }, { "sim":50.0, - "partner":"6s23" + "partner":"6s0g" }, { "sim":50.0, @@ -582074,18 +584461,6 @@ "sim":50.0, "partner":"4eay" }, - { - "sim":50.0, - "partner":"2y46" - }, - { - "sim":50.0, - "partner":"2y5n" - }, - { - "sim":50.0, - "partner":"2yca" - }, { "sim":50.0, "partner":"3zsn" @@ -582108,11 +584483,15 @@ }, { "sim":50.0, - "partner":"4r33" + "partner":"2y46" }, { "sim":50.0, - "partner":"6e9b" + "partner":"2y5n" + }, + { + "sim":50.0, + "partner":"2yca" }, { "sim":50.0, @@ -582130,6 +584509,14 @@ "sim":50.0, "partner":"4u7w" }, + { + "sim":50.0, + "partner":"6e9b" + }, + { + "sim":50.0, + "partner":"4r33" + }, { "sim":50.0, "partner":"3zu2" @@ -582236,7 +584623,7 @@ }, { "sim":50.0, - "partner":"4p8h" + "partner":"4ff6" }, { "sim":50.0, @@ -582244,79 +584631,79 @@ }, { "sim":50.0, - "partner":"5hjx" + "partner":"5hjy" }, { "sim":50.0, - "partner":"5koz" + "partner":"5han" }, { "sim":50.0, - "partner":"6hez" + "partner":"4feh" }, { "sim":50.0, - "partner":"5hjy" + "partner":"6hf3" }, { "sim":50.0, - "partner":"4ff6" + "partner":"4fdn" }, { "sim":50.0, - "partner":"6hf0" + "partner":"4fdo" }, { "sim":50.0, - "partner":"5han" + "partner":"4fdp" }, { "sim":50.0, - "partner":"4feh" + "partner":"5hao" }, { "sim":50.0, - "partner":"4fdn" + "partner":"6g83" }, { "sim":50.0, - "partner":"6hf3" + "partner":"4lf1" }, { "sim":50.0, - "partner":"4fdo" + "partner":"3oqc" }, { "sim":50.0, - "partner":"4fdp" + "partner":"5koz" }, { "sim":50.0, - "partner":"5hao" + "partner":"4lf2" }, { "sim":50.0, - "partner":"4lf1" + "partner":"5hk4" }, { "sim":50.0, - "partner":"6g83" + "partner":"4ncr" }, { "sim":50.0, - "partner":"3oqc" + "partner":"5hjx" }, { "sim":50.0, - "partner":"4lf2" + "partner":"6hez" }, { "sim":50.0, - "partner":"5hk4" + "partner":"4p8h" }, { "sim":50.0, - "partner":"4ncr" + "partner":"6hf0" }, { "sim":50.0, @@ -582372,23 +584759,23 @@ }, { "sim":50.0, - "partner":"2cj9" + "partner":"2cja" }, { "sim":50.0, - "partner":"5o3m" + "partner":"2cim" }, { "sim":50.0, - "partner":"2cja" + "partner":"2cjb" }, { "sim":50.0, - "partner":"2cim" + "partner":"5o3m" }, { "sim":50.0, - "partner":"2cjb" + "partner":"2cj9" }, { "sim":50.0, @@ -582458,10 +584845,6 @@ "sim":50.0, "partner":"2ix1" }, - { - "sim":50.0, - "partner":"2bpo" - }, { "sim":50.0, "partner":"2bf4" @@ -582472,11 +584855,11 @@ }, { "sim":50.0, - "partner":"8god" + "partner":"2bpo" }, { "sim":50.0, - "partner":"6k8s" + "partner":"8god" }, { "sim":50.0, @@ -582486,6 +584869,10 @@ "sim":50.0, "partner":"6k8u" }, + { + "sim":50.0, + "partner":"6k8s" + }, { "sim":50.0, "partner":"5y9d" @@ -582524,15 +584911,15 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"6edz" }, { "sim":50.0, - "partner":"6edz" + "partner":"6ee1" }, { "sim":50.0, - "partner":"6ee1" + "partner":"6edw" }, { "sim":50.0, @@ -582712,93 +585099,93 @@ ], "subtitle":"Broadly neutralizing darpin bnd.9 in complex with the hiv-1 envelope variable loop 3 peptide v3 (bg505)", "tags":[ - "darpin", "de novo protein", - "hiv" + "hiv", + "darpin" ], "keywords":[ - "amphipathic", - "glycoprotein", "trimer", - "conserved", - "abundant", - "designed", - "indispensable", - "envelope", - "variable", - "mutation", - "masking", - "potential", - "target", - "generally", - "based", - "technology", - "access", + "open", + "molecular", + "prefusion", + "crown", "repeat", - "broadly", - "recognized", - "inhibitors", + "key", + "half", + "masking", + "via", + "within", + "protein", "solely", - "cd4", + "binding", "postattachment", - "allows", - "cell", - "neutralizing", - "escape", - "efficient", - "open", "entry", - "highlighting", - "breadth", - "reinstitute", - "dynamics", - "\u03b1v3c", - "bnds", - "v3", - "immunodeficiency", - "attachment", - "targeting", - "neutralization", - "molecular", - "functional", - "amino", - "virus", - "via", - "report", + "relevance", + "rare", + "site", "contact", - "darpins", - "1", - "acids", + "envelope", + "conformational", + "immunodeficiency", + "closed", "underscored", + "access", "trimers", + "termed", + "bound", + "generally", + "ankyrin", + "neutralization", + "bnds", "category", + "1", + "variable", "bnd", "surface", - "key", - "relevance", - "prefusion", - "rare", - "closed", - "analyses", - "conformational", - "termed", + "glycoprotein", + "functional", + "potential", + "targeting", + "third", + "virus", + "attachment", + "cell", + "cd4", + "amino", + "allows", + "highlighting", + "broadly", "90", - "human", - "half", - "ankyrin", + "technology", + "neutralizing", + "inhibition", + "indispensable", + "analyses", + "amphipathic", + "darpins", + "mutation", + "dynamics", + "recognized", + "designed", + "breadth", + "efficient", + "\u03b1v3c", + "conserved", + "loop", + "v3", + "based", "darpin", + "report", + "target", + "escape", "state", - "inhibition", - "binding", - "protein", - "bound", - "crown", - "third", - "within", + "inhibitors", + "reinstitute", + "abundant", "distinct", - "antibodies", - "site", - "loop" + "acids", + "human", + "antibodies" ], "release_date":"2023-08-16", "publication":"\"Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization\", Nat.Struct.Mol.Biol., 30, 1323-1336", @@ -582871,19 +585258,19 @@ }, { "sim":261.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":261.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":261.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":261.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":261.0, @@ -582891,35 +585278,35 @@ }, { "sim":261.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":261.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":261.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":261.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":261.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":261.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":261.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":261.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":260.0, @@ -582939,11 +585326,11 @@ }, { "sim":255.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":255.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":255.0, @@ -582999,11 +585386,11 @@ }, { "sim":241.0, - "partner":"4ydw" + "partner":"5kng" }, { "sim":241.0, - "partner":"5kng" + "partner":"4ydw" }, { "sim":241.0, @@ -583063,7 +585450,7 @@ }, { "sim":224.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":224.0, @@ -583071,15 +585458,15 @@ }, { "sim":224.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":223.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":223.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":223.0, @@ -583123,11 +585510,11 @@ }, { "sim":198.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":198.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":196.0, @@ -583153,6 +585540,10 @@ "sim":186.0, "partner":"2jab" }, + { + "sim":179.0, + "partner":"9glq" + }, { "sim":179.0, "partner":"4hqd" @@ -583223,30 +585614,18 @@ "sim":261.0, "partner":"6bbn" }, - { - "sim":261.0, - "partner":"7yz0" - }, { "sim":261.0, "partner":"6mzf" }, { "sim":261.0, - "partner":"7yz1" - }, - { - "sim":261.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":261.0, "partner":"5nqt" }, - { - "sim":261.0, - "partner":"6mze" - }, { "sim":261.0, "partner":"7yz2" @@ -583257,11 +585636,11 @@ }, { "sim":261.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":261.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":261.0, @@ -583271,13 +585650,17 @@ "sim":261.0, "partner":"7yz5" }, + { + "sim":261.0, + "partner":"7yz6" + }, { "sim":261.0, "partner":"4lnu" }, { "sim":261.0, - "partner":"7yz6" + "partner":"6zwb" }, { "sim":261.0, @@ -583291,10 +585674,6 @@ "sim":261.0, "partner":"5nm5" }, - { - "sim":261.0, - "partner":"6zwb" - }, { "sim":261.0, "partner":"6zwc" @@ -583307,6 +585686,18 @@ "sim":261.0, "partner":"7yyz" }, + { + "sim":261.0, + "partner":"7yz0" + }, + { + "sim":261.0, + "partner":"7yz1" + }, + { + "sim":261.0, + "partner":"7z01" + }, { "sim":259.0, "partner":"3noc" @@ -583341,11 +585732,11 @@ }, { "sim":256.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":256.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":256.0, @@ -583359,45 +585750,25 @@ "sim":255.0, "partner":"5oov" }, - { - "sim":255.0, - "partner":"5eno" - }, - { - "sim":255.0, - "partner":"6zob" - }, - { - "sim":255.0, - "partner":"6zo5" - }, { "sim":255.0, "partner":"4dx6" }, { "sim":255.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":255.0, "partner":"6zoc" }, - { - "sim":255.0, - "partner":"5enp" - }, - { - "sim":255.0, - "partner":"6sgs" - }, { "sim":255.0, "partner":"6zo6" }, { "sim":255.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":255.0, @@ -583405,7 +585776,7 @@ }, { "sim":255.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":255.0, @@ -583413,11 +585784,11 @@ }, { "sim":255.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":255.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":255.0, @@ -583427,6 +585798,10 @@ "sim":255.0, "partner":"6zoe" }, + { + "sim":255.0, + "partner":"5enq" + }, { "sim":255.0, "partner":"6q4p" @@ -583437,19 +585812,19 @@ }, { "sim":255.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":255.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":255.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":255.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":255.0, @@ -583461,23 +585836,23 @@ }, { "sim":255.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":255.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":255.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":255.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":255.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":255.0, @@ -583489,15 +585864,15 @@ }, { "sim":255.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":255.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":255.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":255.0, @@ -583505,15 +585880,19 @@ }, { "sim":255.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":255.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":255.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":255.0, + "partner":"6sgr" }, { "sim":255.0, @@ -583529,15 +585908,23 @@ }, { "sim":255.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":255.0, "partner":"4dx5" }, { - "sim":254.0, - "partner":"5oyj" + "sim":255.0, + "partner":"5eno" + }, + { + "sim":255.0, + "partner":"6zo5" + }, + { + "sim":255.0, + "partner":"6q4n" }, { "sim":254.0, @@ -583547,6 +585934,10 @@ "sim":254.0, "partner":"6gvn" }, + { + "sim":254.0, + "partner":"5oyj" + }, { "sim":254.0, "partner":"5mlb" @@ -583589,11 +585980,11 @@ }, { "sim":252.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":252.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":252.0, @@ -583745,11 +586136,11 @@ }, { "sim":237.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":237.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":237.0, @@ -583775,10 +586166,6 @@ "sim":235.0, "partner":"6ob5" }, - { - "sim":235.0, - "partner":"8g4f" - }, { "sim":235.0, "partner":"8g42" @@ -583795,6 +586182,10 @@ "sim":235.0, "partner":"8g3k" }, + { + "sim":235.0, + "partner":"8g4f" + }, { "sim":235.0, "partner":"6f5e" @@ -583889,11 +586280,11 @@ }, { "sim":223.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":223.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":221.0, @@ -583915,10 +586306,6 @@ "sim":209.0, "partner":"5aq7" }, - { - "sim":206.0, - "partner":"7pd8" - }, { "sim":206.0, "partner":"7pdd" @@ -583931,6 +586318,10 @@ "sim":206.0, "partner":"7pdh" }, + { + "sim":206.0, + "partner":"7pd8" + }, { "sim":204.0, "partner":"5itz" @@ -583945,15 +586336,15 @@ }, { "sim":190.0, - "partner":"6d66" + "partner":"2v4h" }, { "sim":190.0, - "partner":"6d67" + "partner":"6d66" }, { "sim":190.0, - "partner":"2v4h" + "partner":"6d67" }, { "sim":190.0, @@ -584029,23 +586420,23 @@ }, { "sim":120.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":120.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":120.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":120.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":120.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":120.0, @@ -584053,11 +586444,11 @@ }, { "sim":120.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":120.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":120.0, @@ -584121,15 +586512,15 @@ }, { "sim":109.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":109.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":109.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":108.0, @@ -584141,15 +586532,15 @@ }, { "sim":108.0, - "partner":"1uoh" + "partner":"7vo6" }, { "sim":108.0, - "partner":"7vo6" + "partner":"7vxw" }, { "sim":108.0, - "partner":"7vxw" + "partner":"1uoh" }, { "sim":108.0, @@ -584161,11 +586552,11 @@ }, { "sim":108.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":108.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":108.0, @@ -584175,10 +586566,6 @@ "sim":108.0, "partner":"5y4f" }, - { - "sim":107.0, - "partner":"5vhj" - }, { "sim":107.0, "partner":"5vhh" @@ -584207,6 +586594,10 @@ "sim":107.0, "partner":"5vho" }, + { + "sim":107.0, + "partner":"5vhj" + }, { "sim":107.0, "partner":"4nik" @@ -584221,11 +586612,11 @@ }, { "sim":104.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":104.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":102.0, @@ -584363,10 +586754,6 @@ "sim":89.0, "partner":"8wfz" }, - { - "sim":89.0, - "partner":"6v9x" - }, { "sim":89.0, "partner":"6v9y" @@ -584379,6 +586766,10 @@ "sim":89.0, "partner":"6v9w" }, + { + "sim":89.0, + "partner":"6v9x" + }, { "sim":89.0, "partner":"7or0" @@ -584417,11 +586808,11 @@ }, { "sim":88.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":88.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":88.0, @@ -584507,14 +586898,6 @@ "sim":83.0, "partner":"7ddx" }, - { - "sim":83.0, - "partner":"6m11" - }, - { - "sim":83.0, - "partner":"6m12" - }, { "sim":83.0, "partner":"6m13" @@ -584539,6 +586922,14 @@ "sim":83.0, "partner":"4o1p" }, + { + "sim":83.0, + "partner":"6m11" + }, + { + "sim":83.0, + "partner":"6m12" + }, { "sim":83.0, "partner":"7ykr" @@ -584593,19 +586984,19 @@ }, { "sim":80.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":80.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":80.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":80.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":80.0, @@ -584703,10 +587094,6 @@ "sim":72.0, "partner":"5wo6" }, - { - "sim":72.0, - "partner":"5iwr" - }, { "sim":72.0, "partner":"5iwt" @@ -584761,11 +587148,11 @@ }, { "sim":72.0, - "partner":"5wo7" + "partner":"5iwr" }, { - "sim":71.0, - "partner":"6o1p" + "sim":72.0, + "partner":"5wo7" }, { "sim":71.0, @@ -584805,7 +587192,7 @@ }, { "sim":71.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":71.0, @@ -584839,6 +587226,10 @@ "sim":71.0, "partner":"7t6l" }, + { + "sim":71.0, + "partner":"7t6m" + }, { "sim":70.0, "partner":"1d9s" @@ -584859,10 +587250,6 @@ "sim":64.0, "partner":"4hbd" }, - { - "sim":64.0, - "partner":"7k4a" - }, { "sim":64.0, "partner":"7k4b" @@ -584885,7 +587272,7 @@ }, { "sim":64.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":64.0, @@ -584901,7 +587288,7 @@ }, { "sim":64.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":64.0, @@ -584913,7 +587300,7 @@ }, { "sim":64.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":64.0, @@ -584931,6 +587318,10 @@ "sim":64.0, "partner":"6bo8" }, + { + "sim":64.0, + "partner":"6bo9" + }, { "sim":62.0, "partner":"2fo1" @@ -585286,68 +587677,68 @@ "subtitle":"De novo retro-aldolase rabetab-16.1", "tags":[ "de novo protein", - "retro-aldolase", - "beta-barrel" + "beta-barrel", + "retro-aldolase" ], "keywords":[ - "modification", - "makes", - "exciting", - "evolution", - "customization", - "eight", - "results", - "part", - "large", - "use", - "stereoselectivity", - "de", - "novo", - "catalysts", - "enzymes", - "offer", - "scaffolds", - "topologies", - "response", - "directed", - "fold", - "among", - "enzyme", + "unpredictable", "designed", - "generated", - "different", - "distribution", + "property", "reaction", - "active", - "shapes", - "unpredictable", - "specific", - "activity", - "behavior", - "folds", + "alternative", "engineering", "often", - "support", - "amenability", + "behavior", + "directed", + "modification", "show", - "explore", + "active", + "de", + "distribution", + "natural", + "catalysts", + "stereoselectivity", + "different", + "specific", + "fold", + "scaffolds", + "among", + "results", + "diversity", + "could", "model", + "explore", + "makes", + "customization", "protein", + "topologies", "account", - "previous", - "backbone", - "natural", - "sequence", + "large", + "response", "optimize", + "part", + "eight", + "use", + "backbone", + "enzymes", + "novo", + "shapes", + "activity", "native", - "diversity", - "property", - "could", - "alternative", - "stranded", + "support", + "sequence", + "enzyme", + "generated", + "evolution", "suggestions", + "offer", + "inherent", + "stranded", "create", - "inherent" + "amenability", + "folds", + "exciting", + "previous" ], "release_date":"2023-08-16", "publication":"\"Design and optimization of enzymatic activity in a de novo beta-barrel scaffold\", Protein Sci., 31, e4405-e4405", @@ -585507,122 +587898,122 @@ ], "subtitle":"Structure of the k5\/cagi complex", "tags":[ - "type iv secretion system helicobacter pylori pilus", - "toxin" + "toxin", + "type iv secretion system helicobacter pylori pilus" ], "keywords":[ - "helicobacter", - "providing", + "affinity", + "caga", + "dimers", + "role", + "structural", + "development", + "repeat", + "key", "complexes", - "scattering", - "potent", - "cagt4ss", + "mediates", + "three", + "delivery", + "integrative", + "oncoprotein", + "study", "prolonged", - "iv", - "designed", + "globular", + "pathogen", + "spreading", + "bacterial", "explanation", - "40", - "induced", + "cells", + "domains", + "forms", + "subnanomolar", + "two", "purified", - "interact", + "induced", "crystal", - "interacted", - "target", - "caga", - "cagi", - "secretion", - "subnanomolar", - "represent", - "repeat", - "alpha", - "inhibitors", - "pathogen", - "affinity", + "helicobacter", + "using", + "pylori", + "respectively", + "selected", + "identified", "crucial", - "interaction", - "interfaces", + "apparatus", + "elongated", + "bacterium", + "approach", + "interact", + "produces", "proteins", - "solved", - "investigated", - "cell", - "k5", - "spreading", + "adenocarcinoma", + "scattering", + "2", + "ankyrin", + "factor", + "external", "small", - "elongated", - "suggests", + "iv", + "found", + "cagic", + "unclear", + "cancer", + "required", + "surface", + "risk", + "inhibited", "binders", - "cagin", - "structures", - "oncoprotein", - "30", - "three", "65", + "30", + "suggests", "biology", - "mediated", - "attachment", - "role", - "molecules", - "targeting", + "represent", + "translocation", + "40", "properties", - "integrative", - "plays", - "produces", - "thereby", - "respectively", - "globular", - "ags", - "darpins", - "gastric", - "mediates", - "type", - "apparatus", - "pylori", - "using", - "cagic", - "present", - "required", - "surface", - "key", - "formation", - "cells", - "cancer", - "structural", - "selected", - "unclear", "k8", + "targeting", + "fold", + "cagi", + "pilus", "inject", + "attachment", + "cell", + "cagin", + "cagt4ss", + "type", + "alpha", + "formation", + "interaction", + "system", "angle", - "factor", - "delivery", - "bacterial", + "solved", + "levels", + "present", + "inhibition", + "darpins", + "gastric", + "k2", + "designed", + "interfaces", + "investigated", + "providing", + "structures", + "secretion", + "darpin", + "thereby", + "target", + "ags", + "inhibitors", + "plays", + "molecules", + "mediated", "difference", - "approach", - "study", + "k5", + "interacted", "composition", + "potent", "human", - "fold", - "ankyrin", - "external", - "darpin", - "found", - "affinities", - "two", - "identified", - "dimers", - "system", - "translocation", - "inhibition", - "domains", - "levels", - "2", - "adenocarcinoma", - "development", - "bacterium", - "pilus", - "k2", - "risk", - "inhibited", - "forms" + "affinities" ], "release_date":"2023-05-17", "publication":"\"Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system\", Plos Pathog., 19, e1011368-e1011368", @@ -585657,6 +588048,10 @@ "sim":251.0, "partner":"8ak1" }, + { + "sim":209.0, + "partner":"9glq" + }, { "sim":200.0, "partner":"7z73" @@ -585667,11 +588062,11 @@ }, { "sim":195.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":195.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":191.0, @@ -585711,11 +588106,11 @@ }, { "sim":184.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":184.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":184.0, @@ -585775,11 +588170,11 @@ }, { "sim":178.0, - "partner":"2xeh" + "partner":"2xee" }, { "sim":178.0, - "partner":"2xee" + "partner":"2xeh" }, { "sim":178.0, @@ -585799,19 +588194,19 @@ }, { "sim":176.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":176.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":176.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":176.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":176.0, @@ -585819,35 +588214,35 @@ }, { "sim":176.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":176.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":176.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":176.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":176.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":176.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":176.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":176.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":175.0, @@ -585919,7 +588314,7 @@ }, { "sim":166.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":166.0, @@ -585927,7 +588322,7 @@ }, { "sim":166.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":166.0, @@ -585959,11 +588354,11 @@ }, { "sim":164.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":164.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":164.0, @@ -585991,15 +588386,15 @@ }, { "sim":130.0, - "partner":"4gpm" + "partner":"5hry" }, { "sim":130.0, - "partner":"5hry" + "partner":"4hb5" }, { "sim":130.0, - "partner":"4hb5" + "partner":"4gpm" }, { "sim":126.0, @@ -586027,10 +588422,6 @@ "sim":203.0, "partner":"6s9t" }, - { - "sim":202.0, - "partner":"7pd8" - }, { "sim":202.0, "partner":"7pdd" @@ -586043,6 +588434,10 @@ "sim":202.0, "partner":"7pdh" }, + { + "sim":202.0, + "partner":"7pd8" + }, { "sim":190.0, "partner":"4grg" @@ -586113,11 +588508,11 @@ }, { "sim":182.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":182.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":182.0, @@ -586145,11 +588540,11 @@ }, { "sim":181.0, - "partner":"5oyj" + "partner":"2p2c" }, { "sim":181.0, - "partner":"2p2c" + "partner":"5oyj" }, { "sim":181.0, @@ -586299,45 +588694,25 @@ "sim":178.0, "partner":"5h76" }, - { - "sim":177.0, - "partner":"5eno" - }, - { - "sim":177.0, - "partner":"6zob" - }, - { - "sim":177.0, - "partner":"6zo5" - }, { "sim":177.0, "partner":"4dx6" }, { "sim":177.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":177.0, "partner":"6zoc" }, - { - "sim":177.0, - "partner":"5enp" - }, - { - "sim":177.0, - "partner":"6sgs" - }, { "sim":177.0, "partner":"6zo6" }, { "sim":177.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":177.0, @@ -586345,7 +588720,7 @@ }, { "sim":177.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":177.0, @@ -586353,11 +588728,11 @@ }, { "sim":177.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":177.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":177.0, @@ -586367,6 +588742,10 @@ "sim":177.0, "partner":"6zoe" }, + { + "sim":177.0, + "partner":"5enq" + }, { "sim":177.0, "partner":"6q4p" @@ -586377,19 +588756,19 @@ }, { "sim":177.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":177.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":177.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":177.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":177.0, @@ -586401,23 +588780,23 @@ }, { "sim":177.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":177.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":177.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":177.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":177.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":177.0, @@ -586429,15 +588808,15 @@ }, { "sim":177.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":177.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":177.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":177.0, @@ -586445,15 +588824,19 @@ }, { "sim":177.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":177.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":177.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":177.0, + "partner":"6sgr" }, { "sim":177.0, @@ -586469,7 +588852,7 @@ }, { "sim":177.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":177.0, @@ -586477,39 +588860,39 @@ }, { "sim":177.0, - "partner":"5aqb" + "partner":"5eno" }, { - "sim":176.0, - "partner":"6ob5" + "sim":177.0, + "partner":"6zo5" }, { - "sim":176.0, - "partner":"6bbn" + "sim":177.0, + "partner":"6q4n" }, { - "sim":176.0, - "partner":"7yz0" + "sim":177.0, + "partner":"5aqb" }, { "sim":176.0, - "partner":"6mzf" + "partner":"6ob5" }, { "sim":176.0, - "partner":"7yz1" + "partner":"6bbn" }, { "sim":176.0, - "partner":"7z01" + "partner":"6mzf" }, { "sim":176.0, - "partner":"5nqt" + "partner":"6mze" }, { "sim":176.0, - "partner":"6mze" + "partner":"5nqt" }, { "sim":176.0, @@ -586521,11 +588904,11 @@ }, { "sim":176.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":176.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":176.0, @@ -586535,13 +588918,17 @@ "sim":176.0, "partner":"7yz5" }, + { + "sim":176.0, + "partner":"7yz6" + }, { "sim":176.0, "partner":"4lnu" }, { "sim":176.0, - "partner":"7yz6" + "partner":"6zwb" }, { "sim":176.0, @@ -586555,10 +588942,6 @@ "sim":176.0, "partner":"5nm5" }, - { - "sim":176.0, - "partner":"6zwb" - }, { "sim":176.0, "partner":"6zwc" @@ -586575,6 +588958,18 @@ "sim":176.0, "partner":"7yyz" }, + { + "sim":176.0, + "partner":"7yz0" + }, + { + "sim":176.0, + "partner":"7yz1" + }, + { + "sim":176.0, + "partner":"7z01" + }, { "sim":176.0, "partner":"6mwq" @@ -586593,11 +588988,11 @@ }, { "sim":175.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":175.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":175.0, @@ -586657,11 +589052,11 @@ }, { "sim":172.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":172.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":172.0, @@ -586797,11 +589192,11 @@ }, { "sim":155.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":155.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":123.0, @@ -586813,11 +589208,11 @@ }, { "sim":117.0, - "partner":"6ndz" + "partner":"6ne2" }, { "sim":117.0, - "partner":"6ne2" + "partner":"6ndz" }, { "sim":115.0, @@ -586889,23 +589284,23 @@ }, { "sim":91.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":91.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":91.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":91.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":91.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":91.0, @@ -586913,11 +589308,11 @@ }, { "sim":91.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":91.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":91.0, @@ -586953,19 +589348,19 @@ }, { "sim":86.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":86.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":86.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":86.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":86.0, @@ -587017,11 +589412,11 @@ }, { "sim":83.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":83.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":82.0, @@ -587037,15 +589432,15 @@ }, { "sim":81.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":81.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":81.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":81.0, @@ -587249,11 +589644,11 @@ }, { "sim":70.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":70.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":70.0, @@ -587363,10 +589758,6 @@ "sim":64.0, "partner":"6py8" }, - { - "sim":62.0, - "partner":"6v9x" - }, { "sim":62.0, "partner":"6v9y" @@ -587379,6 +589770,10 @@ "sim":62.0, "partner":"6v9w" }, + { + "sim":62.0, + "partner":"6v9x" + }, { "sim":62.0, "partner":"6pqo" @@ -587425,11 +589820,11 @@ }, { "sim":57.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":57.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":57.0, @@ -587467,10 +589862,6 @@ "sim":53.0, "partner":"5wo6" }, - { - "sim":53.0, - "partner":"5iwr" - }, { "sim":53.0, "partner":"5iwt" @@ -587525,19 +589916,19 @@ }, { "sim":53.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":53.0, - "partner":"7xbk" + "partner":"5wo7" }, { "sim":53.0, - "partner":"6e2g" + "partner":"7xbk" }, { "sim":53.0, - "partner":"6o1p" + "partner":"6e2g" }, { "sim":53.0, @@ -587577,7 +589968,7 @@ }, { "sim":53.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":53.0, @@ -587611,6 +590002,10 @@ "sim":53.0, "partner":"7t6l" }, + { + "sim":53.0, + "partner":"7t6m" + }, { "sim":52.0, "partner":"7xc5" @@ -587633,6 +590028,10 @@ "sim":0.9940999746, "partner":"8ak1" }, + { + "sim":0.9765999913, + "partner":"9glq" + }, { "sim":0.9686999917, "partner":"7z73" @@ -587824,122 +590223,122 @@ ], "subtitle":"Crystal structure of a cagi:k2 complex", "tags":[ - "helicobacter pylori type iv secretion system", - "toxin" + "toxin", + "helicobacter pylori type iv secretion system" ], "keywords":[ - "helicobacter", - "providing", + "affinity", + "caga", + "dimers", + "role", + "structural", + "development", + "repeat", + "key", "complexes", - "scattering", - "potent", - "cagt4ss", + "mediates", + "three", + "delivery", + "integrative", + "oncoprotein", + "study", "prolonged", - "iv", - "designed", + "globular", + "pathogen", + "spreading", + "bacterial", "explanation", - "40", - "induced", + "cells", + "domains", + "forms", + "subnanomolar", + "two", "purified", - "interact", + "induced", "crystal", - "interacted", - "target", - "caga", - "cagi", - "secretion", - "subnanomolar", - "represent", - "repeat", - "alpha", - "inhibitors", - "pathogen", - "affinity", + "helicobacter", + "using", + "pylori", + "respectively", + "selected", + "identified", "crucial", - "interaction", - "interfaces", + "apparatus", + "elongated", + "bacterium", + "approach", + "interact", + "produces", "proteins", - "solved", - "investigated", - "cell", - "k5", - "spreading", + "adenocarcinoma", + "scattering", + "2", + "ankyrin", + "factor", + "external", "small", - "elongated", - "suggests", + "iv", + "found", + "cagic", + "unclear", + "cancer", + "required", + "surface", + "risk", + "inhibited", "binders", - "cagin", - "structures", - "oncoprotein", - "30", - "three", "65", + "30", + "suggests", "biology", - "mediated", - "attachment", - "role", - "molecules", - "targeting", + "represent", + "translocation", + "40", "properties", - "integrative", - "plays", - "produces", - "thereby", - "respectively", - "globular", - "ags", - "darpins", - "gastric", - "mediates", - "type", - "apparatus", - "pylori", - "using", - "cagic", - "present", - "required", - "surface", - "key", - "formation", - "cells", - "cancer", - "structural", - "selected", - "unclear", "k8", + "targeting", + "fold", + "cagi", + "pilus", "inject", + "attachment", + "cell", + "cagin", + "cagt4ss", + "type", + "alpha", + "formation", + "interaction", + "system", "angle", - "factor", - "delivery", - "bacterial", + "solved", + "levels", + "present", + "inhibition", + "darpins", + "gastric", + "k2", + "designed", + "interfaces", + "investigated", + "providing", + "structures", + "secretion", + "darpin", + "thereby", + "target", + "ags", + "inhibitors", + "plays", + "molecules", + "mediated", "difference", - "approach", - "study", + "k5", + "interacted", "composition", + "potent", "human", - "fold", - "ankyrin", - "external", - "darpin", - "found", - "affinities", - "two", - "identified", - "dimers", - "system", - "translocation", - "inhibition", - "domains", - "levels", - "2", - "adenocarcinoma", - "development", - "bacterium", - "pilus", - "k2", - "risk", - "inhibited", - "forms" + "affinities" ], "release_date":"2023-05-17", "publication":"\"Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system\", Plos Pathog., 19, e1011368-e1011368", @@ -587986,25 +590385,29 @@ "sim":235.0, "partner":"8u1b" }, + { + "sim":214.0, + "partner":"9glq" + }, { "sim":211.0, "partner":"2jab" }, { "sim":209.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":209.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":207.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":207.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":207.0, @@ -588052,19 +590455,19 @@ }, { "sim":199.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":199.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":199.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":199.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":199.0, @@ -588072,35 +590475,35 @@ }, { "sim":199.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":199.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":199.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":199.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":199.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":199.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":199.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":199.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":197.0, @@ -588176,7 +590579,7 @@ }, { "sim":191.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":191.0, @@ -588184,7 +590587,7 @@ }, { "sim":191.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":191.0, @@ -588224,11 +590627,11 @@ }, { "sim":180.0, - "partner":"2xeh" + "partner":"2xee" }, { "sim":180.0, - "partner":"2xee" + "partner":"2xeh" }, { "sim":179.0, @@ -588276,11 +590679,11 @@ }, { "sim":164.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":164.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":164.0, @@ -588340,10 +590743,6 @@ } ], "seq_thr_sim_natural":[ - { - "sim":246.0, - "partner":"7pd8" - }, { "sim":246.0, "partner":"7pdd" @@ -588356,6 +590755,10 @@ "sim":246.0, "partner":"7pdh" }, + { + "sim":246.0, + "partner":"7pd8" + }, { "sim":237.0, "partner":"6fp8" @@ -588466,11 +590869,11 @@ }, { "sim":204.0, - "partner":"5oyj" + "partner":"6gvm" }, { "sim":204.0, - "partner":"6gvm" + "partner":"5oyj" }, { "sim":203.0, @@ -588516,18 +590919,6 @@ "sim":201.0, "partner":"2v5q" }, - { - "sim":200.0, - "partner":"5eno" - }, - { - "sim":200.0, - "partner":"6zob" - }, - { - "sim":200.0, - "partner":"6zo5" - }, { "sim":200.0, "partner":"4dx6" @@ -588538,27 +590929,19 @@ }, { "sim":200.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":200.0, "partner":"6zoc" }, - { - "sim":200.0, - "partner":"5enp" - }, - { - "sim":200.0, - "partner":"6sgs" - }, { "sim":200.0, "partner":"6zo6" }, { "sim":200.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":200.0, @@ -588566,7 +590949,7 @@ }, { "sim":200.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":200.0, @@ -588574,11 +590957,11 @@ }, { "sim":200.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":200.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":200.0, @@ -588588,6 +590971,10 @@ "sim":200.0, "partner":"6zoe" }, + { + "sim":200.0, + "partner":"5enq" + }, { "sim":200.0, "partner":"6q4p" @@ -588598,19 +590985,19 @@ }, { "sim":200.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":200.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":200.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":200.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":200.0, @@ -588622,23 +591009,23 @@ }, { "sim":200.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":200.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":200.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":200.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":200.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":200.0, @@ -588650,15 +591037,15 @@ }, { "sim":200.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":200.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":200.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":200.0, @@ -588666,15 +591053,19 @@ }, { "sim":200.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":200.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":200.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":200.0, + "partner":"6sgr" }, { "sim":200.0, @@ -588690,35 +591081,35 @@ }, { "sim":200.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":200.0, "partner":"4dx5" }, { - "sim":199.0, - "partner":"7yz0" + "sim":200.0, + "partner":"5eno" }, { - "sim":199.0, - "partner":"6mzf" + "sim":200.0, + "partner":"6zo5" }, { - "sim":199.0, - "partner":"7yz1" + "sim":200.0, + "partner":"6q4n" }, { "sim":199.0, - "partner":"7z01" + "partner":"6mzf" }, { "sim":199.0, - "partner":"5nqt" + "partner":"6mze" }, { "sim":199.0, - "partner":"6mze" + "partner":"5nqt" }, { "sim":199.0, @@ -588730,11 +591121,11 @@ }, { "sim":199.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":199.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":199.0, @@ -588746,11 +591137,11 @@ }, { "sim":199.0, - "partner":"4lnu" + "partner":"7yz6" }, { "sim":199.0, - "partner":"7yz6" + "partner":"4lnu" }, { "sim":199.0, @@ -588758,15 +591149,15 @@ }, { "sim":199.0, - "partner":"4drx" + "partner":"6zwb" }, { "sim":199.0, - "partner":"5nm5" + "partner":"4drx" }, { "sim":199.0, - "partner":"6zwb" + "partner":"5nm5" }, { "sim":199.0, @@ -588784,6 +591175,18 @@ "sim":199.0, "partner":"7yyz" }, + { + "sim":199.0, + "partner":"7yz0" + }, + { + "sim":199.0, + "partner":"7yz1" + }, + { + "sim":199.0, + "partner":"7z01" + }, { "sim":198.0, "partner":"5eyl" @@ -588906,11 +591309,11 @@ }, { "sim":187.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":187.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":187.0, @@ -589018,19 +591421,19 @@ }, { "sim":177.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":177.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":177.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":177.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":172.0, @@ -589062,11 +591465,11 @@ }, { "sim":168.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":168.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":165.0, @@ -589198,23 +591601,23 @@ }, { "sim":94.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":94.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":94.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":94.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":94.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":94.0, @@ -589222,11 +591625,11 @@ }, { "sim":94.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":94.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":94.0, @@ -589262,19 +591665,19 @@ }, { "sim":88.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":88.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":88.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":88.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":88.0, @@ -589322,11 +591725,11 @@ }, { "sim":84.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":84.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":83.0, @@ -589354,15 +591757,15 @@ }, { "sim":83.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":83.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":83.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":82.0, @@ -589562,11 +591965,11 @@ }, { "sim":71.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":71.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":71.0, @@ -589680,10 +592083,6 @@ "sim":65.0, "partner":"6py8" }, - { - "sim":62.0, - "partner":"6v9x" - }, { "sim":62.0, "partner":"6v9y" @@ -589696,6 +592095,10 @@ "sim":62.0, "partner":"6v9w" }, + { + "sim":62.0, + "partner":"6v9x" + }, { "sim":62.0, "partner":"6pqo" @@ -589758,11 +592161,11 @@ }, { "sim":57.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":57.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":56.0, @@ -589792,10 +592195,6 @@ "sim":53.0, "partner":"5wo6" }, - { - "sim":53.0, - "partner":"5iwr" - }, { "sim":53.0, "partner":"5iwt" @@ -589850,19 +592249,19 @@ }, { "sim":53.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":53.0, - "partner":"7xbk" + "partner":"5wo7" }, { "sim":53.0, - "partner":"6e2g" + "partner":"7xbk" }, { "sim":53.0, - "partner":"6o1p" + "partner":"6e2g" }, { "sim":53.0, @@ -589902,7 +592301,7 @@ }, { "sim":53.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":53.0, @@ -589936,6 +592335,10 @@ "sim":53.0, "partner":"7t6l" }, + { + "sim":53.0, + "partner":"7t6m" + }, { "sim":51.0, "partner":"3hra" @@ -589944,10 +592347,6 @@ "sim":50.0, "partner":"2fo1" }, - { - "sim":50.0, - "partner":"7k4a" - }, { "sim":50.0, "partner":"7k4b" @@ -589970,7 +592369,7 @@ }, { "sim":50.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":50.0, @@ -589986,11 +592385,11 @@ }, { "sim":50.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":50.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":50.0, @@ -590007,6 +592406,10 @@ { "sim":50.0, "partner":"6bo8" + }, + { + "sim":50.0, + "partner":"6bo9" } ], "struct_thr_sim_designed":[ @@ -590014,6 +592417,10 @@ "sim":0.9890999794, "partner":"8aiw" }, + { + "sim":0.9850000143, + "partner":"9glq" + }, { "sim":0.9750999808, "partner":"7z73" @@ -590171,7 +592578,7 @@ }, "seq_max_sim_natural":{ "sim":246.0, - "partner":"7pd8" + "partner":"7pdd" }, "struct_max_sim_designed":{ "sim":0.9890999794, @@ -590249,81 +592656,81 @@ "protein fibril" ], "keywords":[ - "derivatives", - "progresses", + "readopt", + "evolutionarily", "glucagon", - "aggregation", "bloodstream", + "progresses", + "highlight", + "ftir", + "aprs", "exendin", - "acidic", - "functional", - "afm", - "monomeric", - "large", - "results", + "role", + "conserved", "protonation", - "gastrointestinal", - "reversible", + "structures", + "functional", + "absence", "group", - "changes", - "family", - "gatekeepers", - "conserved", - "xfxxwl", - "fibrils", - "identify", - "peptides", - "apr", - "stored", "polymorphic", - "1", - "cd", - "receptor", - "determine", + "core", + "secretion", + "derivatives", "residues", + "sensitivity", + "acidic", + "monomeric", + "family", + "nine", "assays", + "results", "short", - "broad", - "readopt", - "region", - "switching", - "absence", - "sensitivity", - "crystal", + "afm", + "aggregation", + "dual", + "reversible", + "cd", + "gatekeepers", "state", - "folded", - "find", + "propose", "vesicles", - "hexapeptide", - "highlight", - "core", + "hormones", + "folded", "follow", - "amyloid", - "structures", - "secretion", - "ftir", + "gastrointestinal", + "ph", + "hexapeptide", + "large", + "binding", + "fibrils", + "changes", + "formation", + "switching", + "broad", + "find", + "identify", "2", - "states", - "propose", - "dual", "segments", - "diminishes", - "sequence", - "motifs", - "nine", - "aprs", - "released", - "formation", - "hormones", + "amyloid", "tht", - "ph", - "major", + "sequence", + "states", "initiate", - "role", - "binding", - "evolutionarily", + "peptides", + "stored", "forms", - "range" + "major", + "diminishes", + "motifs", + "xfxxwl", + "region", + "crystal", + "apr", + "determine", + "range", + "1", + "receptor", + "released" ], "release_date":"2023-08-02", "publication":"\"Polymorphic amyloid nanostructures of hormone peptides involved in glucose homeostasis display reversible amyloid formation\", Nat Commun, 14, 4621-4621", @@ -590445,81 +592852,81 @@ "protein fibril" ], "keywords":[ - "derivatives", - "progresses", + "readopt", + "evolutionarily", "glucagon", - "aggregation", "bloodstream", + "progresses", + "highlight", + "ftir", + "aprs", "exendin", - "acidic", - "functional", - "afm", - "monomeric", - "large", - "results", + "role", + "conserved", "protonation", - "gastrointestinal", - "reversible", + "structures", + "functional", + "absence", "group", - "changes", - "family", - "gatekeepers", - "conserved", - "xfxxwl", - "fibrils", - "identify", - "peptides", - "apr", - "stored", "polymorphic", - "1", - "cd", - "receptor", - "determine", + "core", + "secretion", + "derivatives", "residues", + "sensitivity", + "acidic", + "monomeric", + "family", + "nine", "assays", + "results", "short", - "broad", - "readopt", - "region", - "switching", - "absence", - "sensitivity", - "crystal", + "afm", + "aggregation", + "dual", + "reversible", + "cd", + "gatekeepers", "state", - "folded", - "find", + "propose", "vesicles", - "hexapeptide", - "highlight", - "core", + "hormones", + "folded", "follow", - "amyloid", - "structures", - "secretion", - "ftir", + "gastrointestinal", + "ph", + "hexapeptide", + "large", + "binding", + "fibrils", + "changes", + "formation", + "switching", + "broad", + "find", + "identify", "2", - "states", - "propose", - "dual", "segments", - "diminishes", - "sequence", - "motifs", - "nine", - "aprs", - "released", - "formation", - "hormones", + "amyloid", "tht", - "ph", - "major", + "sequence", + "states", "initiate", - "role", - "binding", - "evolutionarily", + "peptides", + "stored", "forms", - "range" + "major", + "diminishes", + "motifs", + "xfxxwl", + "region", + "crystal", + "apr", + "determine", + "range", + "1", + "receptor", + "released" ], "release_date":"2023-08-02", "publication":"\"Polymorphic amyloid nanostructures of hormone peptides involved in glucose homeostasis display reversible amyloid formation\", Nat Commun, 14, 4621-4621", @@ -590641,81 +593048,81 @@ "protein fibril" ], "keywords":[ - "derivatives", - "progresses", + "readopt", + "evolutionarily", "glucagon", - "aggregation", "bloodstream", + "progresses", + "highlight", + "ftir", + "aprs", "exendin", - "acidic", - "functional", - "afm", - "monomeric", - "large", - "results", + "role", + "conserved", "protonation", - "gastrointestinal", - "reversible", + "structures", + "functional", + "absence", "group", - "changes", - "family", - "gatekeepers", - "conserved", - "xfxxwl", - "fibrils", - "identify", - "peptides", - "apr", - "stored", "polymorphic", - "1", - "cd", - "receptor", - "determine", + "core", + "secretion", + "derivatives", "residues", + "sensitivity", + "acidic", + "monomeric", + "family", + "nine", "assays", + "results", "short", - "broad", - "readopt", - "region", - "switching", - "absence", - "sensitivity", - "crystal", + "afm", + "aggregation", + "dual", + "reversible", + "cd", + "gatekeepers", "state", - "folded", - "find", + "propose", "vesicles", - "hexapeptide", - "highlight", - "core", + "hormones", + "folded", "follow", - "amyloid", - "structures", - "secretion", - "ftir", + "gastrointestinal", + "ph", + "hexapeptide", + "large", + "binding", + "fibrils", + "changes", + "formation", + "switching", + "broad", + "find", + "identify", "2", - "states", - "propose", - "dual", "segments", - "diminishes", - "sequence", - "motifs", - "nine", - "aprs", - "released", - "formation", - "hormones", + "amyloid", "tht", - "ph", - "major", + "sequence", + "states", "initiate", - "role", - "binding", - "evolutionarily", + "peptides", + "stored", "forms", - "range" + "major", + "diminishes", + "motifs", + "xfxxwl", + "region", + "crystal", + "apr", + "determine", + "range", + "1", + "receptor", + "released" ], "release_date":"2023-08-02", "publication":"\"Polymorphic amyloid nanostructures of hormone peptides involved in glucose homeostasis display reversible amyloid formation\", Nat Commun, 14, 4621-4621", @@ -590837,81 +593244,81 @@ "protein fibril" ], "keywords":[ - "derivatives", - "progresses", + "readopt", + "evolutionarily", "glucagon", - "aggregation", "bloodstream", + "progresses", + "highlight", + "ftir", + "aprs", "exendin", - "acidic", - "functional", - "afm", - "monomeric", - "large", - "results", + "role", + "conserved", "protonation", - "gastrointestinal", - "reversible", + "structures", + "functional", + "absence", "group", - "changes", - "family", - "gatekeepers", - "conserved", - "xfxxwl", - "fibrils", - "identify", - "peptides", - "apr", - "stored", "polymorphic", - "1", - "cd", - "receptor", - "determine", + "core", + "secretion", + "derivatives", "residues", + "sensitivity", + "acidic", + "monomeric", + "family", + "nine", "assays", + "results", "short", - "broad", - "readopt", - "region", - "switching", - "absence", - "sensitivity", - "crystal", + "afm", + "aggregation", + "dual", + "reversible", + "cd", + "gatekeepers", "state", - "folded", - "find", + "propose", "vesicles", - "hexapeptide", - "highlight", - "core", + "hormones", + "folded", "follow", - "amyloid", - "structures", - "secretion", - "ftir", + "gastrointestinal", + "ph", + "hexapeptide", + "large", + "binding", + "fibrils", + "changes", + "formation", + "switching", + "broad", + "find", + "identify", "2", - "states", - "propose", - "dual", "segments", - "diminishes", - "sequence", - "motifs", - "nine", - "aprs", - "released", - "formation", - "hormones", + "amyloid", "tht", - "ph", - "major", + "sequence", + "states", "initiate", - "role", - "binding", - "evolutionarily", + "peptides", + "stored", "forms", - "range" + "major", + "diminishes", + "motifs", + "xfxxwl", + "region", + "crystal", + "apr", + "determine", + "range", + "1", + "receptor", + "released" ], "release_date":"2023-08-02", "publication":"\"Polymorphic amyloid nanostructures of hormone peptides involved in glucose homeostasis display reversible amyloid formation\", Nat Commun, 14, 4621-4621", @@ -591037,81 +593444,81 @@ "protein fibril" ], "keywords":[ - "derivatives", - "progresses", + "readopt", + "evolutionarily", "glucagon", - "aggregation", "bloodstream", + "progresses", + "highlight", + "ftir", + "aprs", "exendin", - "acidic", - "functional", - "afm", - "monomeric", - "large", - "results", + "role", + "conserved", "protonation", - "gastrointestinal", - "reversible", + "structures", + "functional", + "absence", "group", - "changes", - "family", - "gatekeepers", - "conserved", - "xfxxwl", - "fibrils", - "identify", - "peptides", - "apr", - "stored", "polymorphic", - "1", - "cd", - "receptor", - "determine", + "core", + "secretion", + "derivatives", "residues", + "sensitivity", + "acidic", + "monomeric", + "family", + "nine", "assays", + "results", "short", - "broad", - "readopt", - "region", - "switching", - "absence", - "sensitivity", - "crystal", + "afm", + "aggregation", + "dual", + "reversible", + "cd", + "gatekeepers", "state", - "folded", - "find", + "propose", "vesicles", - "hexapeptide", - "highlight", - "core", + "hormones", + "folded", "follow", - "amyloid", - "structures", - "secretion", - "ftir", + "gastrointestinal", + "ph", + "hexapeptide", + "large", + "binding", + "fibrils", + "changes", + "formation", + "switching", + "broad", + "find", + "identify", "2", - "states", - "propose", - "dual", "segments", - "diminishes", - "sequence", - "motifs", - "nine", - "aprs", - "released", - "formation", - "hormones", + "amyloid", "tht", - "ph", - "major", + "sequence", + "states", "initiate", - "role", - "binding", - "evolutionarily", + "peptides", + "stored", "forms", - "range" + "major", + "diminishes", + "motifs", + "xfxxwl", + "region", + "crystal", + "apr", + "determine", + "range", + "1", + "receptor", + "released" ], "release_date":"2023-08-02", "publication":"\"Polymorphic amyloid nanostructures of hormone peptides involved in glucose homeostasis display reversible amyloid formation\", Nat Commun, 14, 4621-4621", @@ -591221,93 +593628,93 @@ ], "subtitle":"Solution structure of nanofast\/hbr-dom2 complex", "tags":[ - "spatial structure", - "nanofast", - "fluorogen-activating protein", - "dynamics", - "fluorogen", "fluorescent protein", - "ligand sepcificity", + "fluorogen-activating protein", "binding constatnt", - "fast" + "ligand sepcificity", + "spatial structure", + "fluorogen", + "fast", + "dynamics", + "nanofast" ], "keywords":[ - "variant", + "molecule", + "constants", + "complex", "deleted", - "domain", - "remaining", - "spatial", - "data", - "ligand", - "propensity", + "behavior", + "allow", + "energy", "one", - "part", + "investigated", "another", - "directly", - "lowest", - "reveals", - "shortened", "specificity", - "investigated", - "details", + "tag", + "hydrophobic", + "limits", + "fluorogen", + "spectroscopy", "serves", - "works", + "reason", + "cavity", + "smallest", "intermolecular", - "suggest", - "contact", - "tag", + "directly", + "spatial", + "domain", + "nicely", + "ligand", "encodable", + "free", "explains", - "smallest", - "substantially", - "spectroscopy", - "allow", + "structure", + "enhances", "tags", - "limits", - "reservoir", - "constants", + "truncation", + "fluorescent", + "variant", + "considered", + "ligands", + "affect", + "details", + "bonding", "provide", + "selects", "fast", - "optimal", - "enhances", - "nicely", - "behavior", - "apo", + "within", + "nmr", "state", - "selects", - "find", - "considered", - "atomistic", - "hydrogen", - "nanofast", - "dynamics", - "bonding", - "applicability", - "cavity", - "fluorogen", "protein", "interactions", - "using", - "reason", - "complex", - "hydrophobic", - "nmr", - "solution", - "structure", - "showed", - "truncation", - "energy", - "ligands", - "within", - "destabilizes", - "affect", + "works", "known", - "free", - "packing", + "propensity", + "lowest", + "part", + "shortened", + "solution", "binding", - "molecule", "dissociation", - "fluorescent" + "packing", + "showed", + "find", + "hydrogen", + "applicability", + "suggest", + "substantially", + "apo", + "contact", + "reveals", + "data", + "destabilizes", + "reservoir", + "atomistic", + "optimal", + "using", + "dynamics", + "nanofast", + "remaining" ], "release_date":"2022-11-23", "publication":"\"Spatial Structure of NanoFAST in the Apo State and in Complex with its Fluorogen HBR-DOM2\", Int J Mol Sci, 23", @@ -591364,10 +593771,6 @@ "sim":188.0, "partner":"1xfn" }, - { - "sim":188.0, - "partner":"6p4i" - }, { "sim":188.0, "partner":"5hds" @@ -591386,11 +593789,11 @@ }, { "sim":188.0, - "partner":"6p5e" + "partner":"8dzx" }, { "sim":188.0, - "partner":"8dzx" + "partner":"6p5e" }, { "sim":188.0, @@ -591398,11 +593801,15 @@ }, { "sim":188.0, - "partner":"5hdc" + "partner":"6p5g" }, { "sim":188.0, - "partner":"6p5g" + "partner":"8e1k" + }, + { + "sim":188.0, + "partner":"5hdc" }, { "sim":188.0, @@ -591414,11 +593821,11 @@ }, { "sim":188.0, - "partner":"8e1k" + "partner":"5hd5" }, { "sim":188.0, - "partner":"5hd5" + "partner":"6p4i" }, { "sim":188.0, @@ -591430,227 +593837,227 @@ }, { "sim":187.0, - "partner":"1nwz" + "partner":"1t1a" }, { "sim":187.0, - "partner":"1ota" + "partner":"4bbv" }, { "sim":187.0, - "partner":"4wl9" + "partner":"1t1b" }, { "sim":187.0, - "partner":"1otb" + "partner":"2qj5" }, { "sim":187.0, - "partner":"1t18" + "partner":"2qws" }, { "sim":187.0, - "partner":"3ve3" + "partner":"4i3i" }, { "sim":187.0, - "partner":"4bbt" + "partner":"1t1c" }, { "sim":187.0, - "partner":"4wla" + "partner":"1ts6" }, { "sim":187.0, - "partner":"1t19" + "partner":"4i3j" }, { "sim":187.0, - "partner":"3ve4" + "partner":"8dzu" }, { "sim":187.0, - "partner":"4bbu" + "partner":"1ts7" }, { "sim":187.0, - "partner":"1t1a" + "partner":"1ote" }, { "sim":187.0, - "partner":"4bbv" + "partner":"1ts8" }, { "sim":187.0, - "partner":"1t1b" + "partner":"2d01" }, { "sim":187.0, - "partner":"2qj5" + "partner":"2phy" }, { "sim":187.0, - "partner":"2qws" + "partner":"2qj7" }, { "sim":187.0, - "partner":"4i3i" + "partner":"2zoh" }, { "sim":187.0, - "partner":"1t1c" + "partner":"8e09" }, { "sim":187.0, - "partner":"1ts6" + "partner":"2zoi" }, { "sim":187.0, - "partner":"4i3j" + "partner":"4i38" }, { "sim":187.0, - "partner":"1ts7" + "partner":"4i39" }, { "sim":187.0, - "partner":"1ote" + "partner":"6mhi" }, { "sim":187.0, - "partner":"1ts8" + "partner":"4i3a" }, { "sim":187.0, - "partner":"2d01" + "partner":"5gx9" }, { "sim":187.0, - "partner":"2phy" + "partner":"3umd" }, { "sim":187.0, - "partner":"2qj7" + "partner":"2pyr" }, { "sim":187.0, - "partner":"2zoh" + "partner":"3ume" }, { "sim":187.0, - "partner":"2zoi" + "partner":"1s1y" }, { "sim":187.0, - "partner":"8dzu" + "partner":"1oti" }, { "sim":187.0, - "partner":"4i38" + "partner":"1s1z" }, { "sim":187.0, - "partner":"8e09" + "partner":"1s4r" }, { "sim":187.0, - "partner":"4i39" + "partner":"1uwn" }, { "sim":187.0, - "partner":"4i3a" + "partner":"1s4s" }, { "sim":187.0, - "partner":"5gx9" + "partner":"6mhn" }, { "sim":187.0, - "partner":"6mhi" + "partner":"8e1l" }, { "sim":187.0, - "partner":"3umd" + "partner":"1ot6" }, { "sim":187.0, - "partner":"2pyr" + "partner":"1uwp" }, { "sim":187.0, - "partner":"3ume" + "partner":"4hy8" }, { "sim":187.0, - "partner":"1s1y" + "partner":"1ts0" }, { "sim":187.0, - "partner":"1oti" + "partner":"3phy" }, { "sim":187.0, - "partner":"1s1z" + "partner":"1kou" }, { "sim":187.0, - "partner":"1s4r" + "partner":"3pyp" }, { "sim":187.0, - "partner":"1uwn" + "partner":"1ugu" }, { "sim":187.0, - "partner":"1s4s" + "partner":"1ot9" }, { "sim":187.0, - "partner":"1ot6" + "partner":"4b9o" }, { "sim":187.0, - "partner":"1uwp" + "partner":"1nwz" }, { "sim":187.0, - "partner":"6mhn" + "partner":"1ota" }, { "sim":187.0, - "partner":"4hy8" + "partner":"4wl9" }, { "sim":187.0, - "partner":"8e1l" + "partner":"1otb" }, { "sim":187.0, - "partner":"1ts0" + "partner":"1t18" }, { "sim":187.0, - "partner":"3phy" + "partner":"3ve3" }, { "sim":187.0, - "partner":"1kou" + "partner":"4bbt" }, { "sim":187.0, - "partner":"3pyp" + "partner":"4wla" }, { "sim":187.0, - "partner":"1ugu" + "partner":"1t19" }, { "sim":187.0, - "partner":"1ot9" + "partner":"3ve4" }, { "sim":187.0, - "partner":"4b9o" + "partner":"4bbu" }, { "sim":187.0, @@ -591672,10 +594079,6 @@ "sim":186.0, "partner":"1odv" }, - { - "sim":186.0, - "partner":"8e03" - }, { "sim":186.0, "partner":"2d02" @@ -591685,24 +594088,24 @@ "partner":"7sjj" }, { - "sim":185.0, - "partner":"8e02" + "sim":186.0, + "partner":"8e03" }, { "sim":185.0, - "partner":"7spx" + "partner":"1f9i" }, { "sim":185.0, - "partner":"1f9i" + "partner":"8dzy" }, { "sim":185.0, - "partner":"8dzy" + "partner":"8e02" }, { - "sim":184.0, - "partner":"7spw" + "sim":185.0, + "partner":"7spx" }, { "sim":184.0, @@ -591728,6 +594131,10 @@ "sim":184.0, "partner":"7spv" }, + { + "sim":184.0, + "partner":"7spw" + }, { "sim":181.0, "partner":"1gsx" @@ -591819,93 +594226,93 @@ ], "subtitle":"Solution structure of nanofast fluorogen-activating protein in the apo state", "tags":[ - "spatial structure", - "nanofast", - "fluorogen-activating protein", - "dynamics", - "fluorogen", "fluorescent protein", - "ligand sepcificity", + "fluorogen-activating protein", "binding constatnt", - "fast" + "ligand sepcificity", + "spatial structure", + "fluorogen", + "fast", + "dynamics", + "nanofast" ], "keywords":[ - "variant", + "molecule", + "constants", + "complex", "deleted", - "domain", - "remaining", - "spatial", - "data", - "ligand", - "propensity", + "behavior", + "allow", + "energy", "one", - "part", + "investigated", "another", - "directly", - "lowest", - "reveals", - "shortened", "specificity", - "investigated", - "details", + "tag", + "hydrophobic", + "limits", + "fluorogen", + "spectroscopy", "serves", - "works", + "reason", + "cavity", + "smallest", "intermolecular", - "suggest", - "contact", - "tag", + "directly", + "spatial", + "domain", + "nicely", + "ligand", "encodable", + "free", "explains", - "smallest", - "substantially", - "spectroscopy", - "allow", + "structure", + "enhances", "tags", - "limits", - "reservoir", - "constants", + "truncation", + "fluorescent", + "variant", + "considered", + "ligands", + "affect", + "details", + "bonding", "provide", + "selects", "fast", - "optimal", - "enhances", - "nicely", - "behavior", - "apo", + "within", + "nmr", "state", - "selects", - "find", - "considered", - "atomistic", - "hydrogen", - "nanofast", - "dynamics", - "bonding", - "applicability", - "cavity", - "fluorogen", "protein", "interactions", - "using", - "reason", - "complex", - "hydrophobic", - "nmr", - "solution", - "structure", - "showed", - "truncation", - "energy", - "ligands", - "within", - "destabilizes", - "affect", + "works", "known", - "free", - "packing", + "propensity", + "lowest", + "part", + "shortened", + "solution", "binding", - "molecule", "dissociation", - "fluorescent" + "packing", + "showed", + "find", + "hydrogen", + "applicability", + "suggest", + "substantially", + "apo", + "contact", + "reveals", + "data", + "destabilizes", + "reservoir", + "atomistic", + "optimal", + "using", + "dynamics", + "nanofast", + "remaining" ], "release_date":"2022-11-23", "publication":"\"Spatial Structure of NanoFAST in the Apo State and in Complex with its Fluorogen HBR-DOM2\", Int J Mol Sci, 23", @@ -591962,10 +594369,6 @@ "sim":188.0, "partner":"1xfn" }, - { - "sim":188.0, - "partner":"6p4i" - }, { "sim":188.0, "partner":"5hds" @@ -591984,11 +594387,11 @@ }, { "sim":188.0, - "partner":"6p5e" + "partner":"8dzx" }, { "sim":188.0, - "partner":"8dzx" + "partner":"6p5e" }, { "sim":188.0, @@ -591996,11 +594399,15 @@ }, { "sim":188.0, - "partner":"5hdc" + "partner":"6p5g" }, { "sim":188.0, - "partner":"6p5g" + "partner":"8e1k" + }, + { + "sim":188.0, + "partner":"5hdc" }, { "sim":188.0, @@ -592012,11 +594419,11 @@ }, { "sim":188.0, - "partner":"8e1k" + "partner":"5hd5" }, { "sim":188.0, - "partner":"5hd5" + "partner":"6p4i" }, { "sim":188.0, @@ -592028,227 +594435,227 @@ }, { "sim":187.0, - "partner":"1nwz" + "partner":"1t1a" }, { "sim":187.0, - "partner":"1ota" + "partner":"4bbv" }, { "sim":187.0, - "partner":"4wl9" + "partner":"1t1b" }, { "sim":187.0, - "partner":"1otb" + "partner":"2qj5" }, { "sim":187.0, - "partner":"1t18" + "partner":"2qws" }, { "sim":187.0, - "partner":"3ve3" + "partner":"4i3i" }, { "sim":187.0, - "partner":"4bbt" + "partner":"1t1c" }, { "sim":187.0, - "partner":"4wla" + "partner":"1ts6" }, { "sim":187.0, - "partner":"1t19" + "partner":"4i3j" }, { "sim":187.0, - "partner":"3ve4" + "partner":"8dzu" }, { "sim":187.0, - "partner":"4bbu" + "partner":"1ts7" }, { "sim":187.0, - "partner":"1t1a" + "partner":"1ote" }, { "sim":187.0, - "partner":"4bbv" + "partner":"1ts8" }, { "sim":187.0, - "partner":"1t1b" + "partner":"2d01" }, { "sim":187.0, - "partner":"2qj5" + "partner":"2phy" }, { "sim":187.0, - "partner":"2qws" + "partner":"2qj7" }, { "sim":187.0, - "partner":"4i3i" + "partner":"2zoh" }, { "sim":187.0, - "partner":"1t1c" + "partner":"8e09" }, { "sim":187.0, - "partner":"1ts6" + "partner":"2zoi" }, { "sim":187.0, - "partner":"4i3j" + "partner":"4i38" }, { "sim":187.0, - "partner":"1ts7" + "partner":"4i39" }, { "sim":187.0, - "partner":"1ote" + "partner":"6mhi" }, { "sim":187.0, - "partner":"1ts8" + "partner":"4i3a" }, { "sim":187.0, - "partner":"2d01" + "partner":"5gx9" }, { "sim":187.0, - "partner":"2phy" + "partner":"3umd" }, { "sim":187.0, - "partner":"2qj7" + "partner":"2pyr" }, { "sim":187.0, - "partner":"2zoh" + "partner":"3ume" }, { "sim":187.0, - "partner":"2zoi" + "partner":"1s1y" }, { "sim":187.0, - "partner":"8dzu" + "partner":"1oti" }, { "sim":187.0, - "partner":"4i38" + "partner":"1s1z" }, { "sim":187.0, - "partner":"8e09" + "partner":"1s4r" }, { "sim":187.0, - "partner":"4i39" + "partner":"1uwn" }, { "sim":187.0, - "partner":"4i3a" + "partner":"1s4s" }, { "sim":187.0, - "partner":"5gx9" + "partner":"6mhn" }, { "sim":187.0, - "partner":"6mhi" + "partner":"8e1l" }, { "sim":187.0, - "partner":"3umd" + "partner":"1ot6" }, { "sim":187.0, - "partner":"2pyr" + "partner":"1uwp" }, { "sim":187.0, - "partner":"3ume" + "partner":"4hy8" }, { "sim":187.0, - "partner":"1s1y" + "partner":"1ts0" }, { "sim":187.0, - "partner":"1oti" + "partner":"3phy" }, { "sim":187.0, - "partner":"1s1z" + "partner":"1kou" }, { "sim":187.0, - "partner":"1s4r" + "partner":"3pyp" }, { "sim":187.0, - "partner":"1uwn" + "partner":"1ugu" }, { "sim":187.0, - "partner":"1s4s" + "partner":"1ot9" }, { "sim":187.0, - "partner":"1ot6" + "partner":"4b9o" }, { "sim":187.0, - "partner":"1uwp" + "partner":"1nwz" }, { "sim":187.0, - "partner":"6mhn" + "partner":"1ota" }, { "sim":187.0, - "partner":"4hy8" + "partner":"4wl9" }, { "sim":187.0, - "partner":"8e1l" + "partner":"1otb" }, { "sim":187.0, - "partner":"1ts0" + "partner":"1t18" }, { "sim":187.0, - "partner":"3phy" + "partner":"3ve3" }, { "sim":187.0, - "partner":"1kou" + "partner":"4bbt" }, { "sim":187.0, - "partner":"3pyp" + "partner":"4wla" }, { "sim":187.0, - "partner":"1ugu" + "partner":"1t19" }, { "sim":187.0, - "partner":"1ot9" + "partner":"3ve4" }, { "sim":187.0, - "partner":"4b9o" + "partner":"4bbu" }, { "sim":187.0, @@ -592270,10 +594677,6 @@ "sim":186.0, "partner":"1odv" }, - { - "sim":186.0, - "partner":"8e03" - }, { "sim":186.0, "partner":"2d02" @@ -592283,24 +594686,24 @@ "partner":"7sjj" }, { - "sim":185.0, - "partner":"8e02" + "sim":186.0, + "partner":"8e03" }, { "sim":185.0, - "partner":"7spx" + "partner":"1f9i" }, { "sim":185.0, - "partner":"1f9i" + "partner":"8dzy" }, { "sim":185.0, - "partner":"8dzy" + "partner":"8e02" }, { - "sim":184.0, - "partner":"7spw" + "sim":185.0, + "partner":"7spx" }, { "sim":184.0, @@ -592326,6 +594729,10 @@ "sim":184.0, "partner":"7spv" }, + { + "sim":184.0, + "partner":"7spw" + }, { "sim":181.0, "partner":"1gsx" @@ -592444,11 +594851,11 @@ "seq_thr_sim_designed":[ { "sim":56.0, - "partner":"7bav" + "partner":"7bas" }, { "sim":56.0, - "partner":"7bas" + "partner":"7bav" }, { "sim":55.0, @@ -592467,14 +594874,14 @@ "sim":0.9973000288, "partner":"7bas" }, - { - "sim":0.9973000288, - "partner":"8a09" - }, { "sim":0.9973999858, "partner":"7bav" }, + { + "sim":0.9973000288, + "partner":"8a09" + }, { "sim":0.9972000122, "partner":"4pn9" @@ -592496,149 +594903,145 @@ "partner":"7a1t" }, { - "sim":0.9986000061, - "partner":"4pna" + "sim":0.9973000288, + "partner":"6xy1" }, { - "sim":0.9983999729, - "partner":"7nfk" + "sim":0.9987000227, + "partner":"7nfo" }, { - "sim":1.0, - "partner":"6g6f" + "sim":0.9986000061, + "partner":"4pna" }, { - "sim":0.9947000146, - "partner":"7baw" + "sim":0.9921000004, + "partner":"6g6d" }, { - "sim":0.9973000288, - "partner":"7nfj" + "sim":0.9983999729, + "partner":"7nfk" }, { "sim":0.9986000061, - "partner":"5ez8" - }, - { - "sim":0.9850999713, - "partner":"7bat" + "partner":"7nfg" }, { "sim":0.9973000288, - "partner":"6xy1" + "partner":"7nfj" }, { - "sim":0.9987000227, - "partner":"7nfo" + "sim":0.9986000061, + "partner":"5ez8" }, { "sim":1.0, - "partner":"6eik" + "partner":"6g6f" }, { - "sim":0.9973000288, - "partner":"7nfl" + "sim":0.9955999851, + "partner":"7nff" }, { "sim":0.9973000288, - "partner":"5ez9" - }, - { - "sim":0.9923999906, - "partner":"6g6b" + "partner":"7nfl" }, { - "sim":0.9921000004, - "partner":"6g6d" + "sim":0.9943000078, + "partner":"6yb0" }, { - "sim":1.0, - "partner":"7nfh" + "sim":0.9850999713, + "partner":"7bat" }, { - "sim":0.986100018, - "partner":"6g6a" + "sim":0.9947000146, + "partner":"7baw" }, { "sim":0.996999979, - "partner":"7nfn" - }, - { - "sim":0.9940000176, - "partner":"6zt1" + "partner":"7nfi" }, { - "sim":0.9958000183, - "partner":"5ezc" + "sim":0.9666000009, + "partner":"9gf2" }, { - "sim":0.9943000078, - "partner":"6yb0" + "sim":1.0, + "partner":"6eik" }, { "sim":0.9897999763, "partner":"6g6g" }, { - "sim":0.9882000089, - "partner":"7bo9" + "sim":0.993900001, + "partner":"6yb2" }, { - "sim":0.9986000061, - "partner":"7nfg" + "sim":1.0, + "partner":"7nfh" }, { - "sim":0.9955999851, - "partner":"7nff" + "sim":0.9955000281, + "partner":"6xxz" }, { "sim":0.996999979, - "partner":"7nfi" + "partner":"7nfm" + }, + { + "sim":0.9973000288, + "partner":"5ez9" }, { "sim":0.9944999814, "partner":"6g69" }, { - "sim":0.9952999949, - "partner":"6yaz" + "sim":0.9937999845, + "partner":"6g6c" }, { - "sim":0.9955000281, - "partner":"6xxz" + "sim":0.9952999949, + "partner":"6yaz" }, { - "sim":0.993900001, - "partner":"6yb2" + "sim":0.9923999906, + "partner":"6g6b" }, { "sim":0.996999979, - "partner":"7nfm" + "partner":"7nfn" }, { "sim":0.992299974, "partner":"5eza" }, - { - "sim":0.9937999845, - "partner":"6g6c" - }, { "sim":0.9952999949, "partner":"7nfp" }, { - "sim":0.996900022, - "partner":"6xy0" + "sim":0.986100018, + "partner":"6g6a" }, { - "sim":0.991599977, - "partner":"7bo8" + "sim":0.9958000183, + "partner":"5ezc" + }, + { + "sim":0.9940000176, + "partner":"6zt1" }, { "sim":0.9750000238, "partner":"6g68" }, + { + "sim":0.996900022, + "partner":"6xy0" + }, { "sim":0.9707000256, "partner":"6g65" @@ -592651,6 +595054,14 @@ "sim":0.9735000134, "partner":"6g66" }, + { + "sim":0.9882000089, + "partner":"7bo9" + }, + { + "sim":0.991599977, + "partner":"7bo8" + }, { "sim":0.9733999968, "partner":"4pn8" @@ -592677,7 +595088,7 @@ ], "seq_max_sim_designed":{ "sim":56.0, - "partner":"7bav" + "partner":"7bas" }, "seq_max_sim_natural":[ @@ -592786,11 +595197,11 @@ }, { "sim":1.0, - "partner":"8a09" + "partner":"7bav" }, { "sim":1.0, - "partner":"7bav" + "partner":"8a09" }, { "sim":1.0, @@ -592802,11 +595213,11 @@ }, { "sim":1.0, - "partner":"7bau" + "partner":"7bim" }, { "sim":1.0, - "partner":"7bim" + "partner":"7bau" }, { "sim":1.0, @@ -592814,15 +595225,19 @@ }, { "sim":1.0, - "partner":"4pna" + "partner":"7nfo" + }, + { + "sim":0.9966999888, + "partner":"6g6d" }, { "sim":1.0, - "partner":"7nfo" + "partner":"6xy1" }, { "sim":1.0, - "partner":"5ez8" + "partner":"4pna" }, { "sim":0.9986000061, @@ -592830,11 +595245,11 @@ }, { "sim":1.0, - "partner":"7bat" + "partner":"7nff" }, { "sim":1.0, - "partner":"7baw" + "partner":"7nfg" }, { "sim":1.0, @@ -592842,43 +595257,35 @@ }, { "sim":1.0, - "partner":"7nfk" + "partner":"7nfm" }, { "sim":1.0, - "partner":"6xy1" + "partner":"5ez8" }, { "sim":1.0, - "partner":"6g6f" - }, - { - "sim":0.9962999821, - "partner":"6eik" + "partner":"5eza" }, { "sim":1.0, - "partner":"7nfl" + "partner":"6g6f" }, { "sim":1.0, - "partner":"5ezc" - }, - { - "sim":0.9966999888, - "partner":"6g6d" + "partner":"7baw" }, { "sim":1.0, - "partner":"5ez9" + "partner":"7nfi" }, { - "sim":0.996900022, - "partner":"6g6a" + "sim":1.0, + "partner":"7nfl" }, { "sim":1.0, - "partner":"7nfh" + "partner":"7nfp" }, { "sim":0.9769999981, @@ -592886,55 +595293,55 @@ }, { "sim":1.0, - "partner":"6zt1" + "partner":"7nfk" }, { "sim":1.0, - "partner":"7nfn" + "partner":"6g6c" }, { - "sim":0.9575999975, - "partner":"5eze" + "sim":1.0, + "partner":"7bat" }, { "sim":1.0, - "partner":"6g69" + "partner":"5ez9" }, { "sim":1.0, - "partner":"7bo9" + "partner":"5ezc" }, { "sim":1.0, - "partner":"6g6g" + "partner":"6g69" }, { "sim":1.0, - "partner":"5eza" + "partner":"6yb2" }, { "sim":1.0, - "partner":"7nff" + "partner":"6g6g" }, { - "sim":1.0, - "partner":"7nfg" + "sim":0.9962999821, + "partner":"6eik" }, { "sim":1.0, - "partner":"7nfm" + "partner":"7nfn" }, { "sim":1.0, - "partner":"7nfp" + "partner":"7nfh" }, { "sim":1.0, - "partner":"7nfi" + "partner":"6xxz" }, { - "sim":1.0, - "partner":"6g6c" + "sim":0.996900022, + "partner":"6g6a" }, { "sim":0.9761999846, @@ -592942,43 +595349,47 @@ }, { "sim":1.0, - "partner":"6xxz" + "partner":"6g68" }, { "sim":1.0, - "partner":"6yb2" + "partner":"6zt1" }, { - "sim":1.0, - "partner":"7bo8" + "sim":0.9987000227, + "partner":"6g65" }, { "sim":1.0, - "partner":"6g68" + "partner":"6g67" }, { "sim":1.0, "partner":"6xy0" }, - { - "sim":0.9987000227, - "partner":"6g65" - }, { "sim":1.0, - "partner":"6g67" + "partner":"6g66" }, { "sim":1.0, - "partner":"6g66" + "partner":"7bo8" }, { - "sim":0.9761999846, - "partner":"4pn8" + "sim":1.0, + "partner":"7bo9" }, { "sim":0.992200017, "partner":"6i1j" + }, + { + "sim":0.9575999975, + "partner":"5eze" + }, + { + "sim":0.9761999846, + "partner":"4pn8" } ], "struct_thr_sim_natural":[ @@ -593046,10 +595457,10 @@ "subtitle":"Structure of cc-tri with aib@b,c: cc-tri-(ubuc)4", "tags":[ "trimer", - "aib", - "de novo protein", "coiled coil", - "2-aminoisobutyric acid" + "2-aminoisobutyric acid", + "aib", + "de novo protein" ], "keywords":[ "description", @@ -593090,10 +595501,6 @@ ], "struct_thr_sim_designed":[ - { - "sim":0.9933000207, - "partner":"7qwc" - }, { "sim":0.9973999858, "partner":"8bfe" @@ -593109,6 +595516,10 @@ { "sim":0.9932000041, "partner":"3r4h" + }, + { + "sim":0.9933000207, + "partner":"7qwc" } ], "struct_thr_sim_natural":[ @@ -593203,88 +595614,88 @@ ], "subtitle":"X-ray crystal structure of a de novo designed helix-loop-helix homodimer in an anti arrangement, cc-hp1.0", "tags":[ + "coiled coil", "de novo protein design", - "4-helix bundle", - "helix-loop-helix dimer", "de novo protein", - "coiled coil" + "helix-loop-helix dimer", + "4-helix bundle" ], "keywords":[ - "library", - "demonstrate", - "designs", - "confirm", - "many", - "tested", - "proteins", - "exemplar", + "designed", + "form", + "fluorescence", + "heterodimeric", + "typically", + "finally", + "mammalian", "thanks", - "established", - "components", - "coli", + "hairpins", + "design", + "subcellular", + "many", "bundles", + "however", + "bimolecular", "de", - "novo", - "modules", - "controllably", - "crystallography", - "identify", - "typically", - "designed", - "together", - "finally", - "would", - "benefit", + "starting", + "biology", + "rationally", "processes", - "heterodimeric", - "useful", - "provide", - "guaranteed", - "characterize", - "bring", - "complementary", - "vitro", + "points", "particularly", + "tested", "application", - "points", - "complementation", - "biophysics", + "synthetic", + "provide", + "good", + "library", + "complexity", + "characterize", + "crystallography", + "interactions", + "protein", + "useful", "relationships", - "design", + "function", + "bring", "reduced", - "characterization", + "modules", + "would", + "proteins", "helical", + "vitro", + "heterodimerize", + "cellular", + "characterization", + "pair", + "together", + "identify", + "coli", + "novo", + "cells", + "demonstrate", + "polypeptides", + "established", + "controllably", "transcription", - "synthetic", - "protein", - "interactions", - "rationally", + "guaranteed", + "benefit", + "components", + "homodimer", + "orthogonally", + "confirm", "applications", - "using", - "mammalian", - "complexity", + "exemplar", + "complementation", + "depend", "describe", "construct", - "function", - "pairs", - "cellular", - "good", - "hairpins", - "biology", - "homodimer", - "bimolecular", + "designs", "regulating", - "form", - "fluorescence", - "however", - "cells", - "polypeptides", - "heterodimerize", - "starting", - "depend", - "pair", - "subcellular", - "orthogonally" + "complementary", + "using", + "pairs", + "biophysics" ], "release_date":"2023-06-07", "publication":"\"Design and Selection of Heterodimerizing Helical Hairpins for Synthetic Biology\", Acs Synth Biol, 12, 1845-1858", @@ -593428,88 +595839,88 @@ ], "subtitle":"X-ray crystal structure of a de novo selected helix-loop-helix heterodimer in a syn arrangement, 26alpha\/26beta", "tags":[ + "coiled coil", + "de novo protein", "4-helix bundle", "protein-protein interactions", - "in-cell library screening", - "de novo protein", - "coiled coil" + "in-cell library screening" ], "keywords":[ - "library", - "demonstrate", - "designs", - "confirm", - "many", - "tested", - "proteins", - "exemplar", + "designed", + "form", + "fluorescence", + "heterodimeric", + "typically", + "finally", + "mammalian", "thanks", - "established", - "components", - "coli", + "hairpins", + "design", + "subcellular", + "many", "bundles", + "however", + "bimolecular", "de", - "novo", - "modules", - "controllably", - "crystallography", - "identify", - "typically", - "designed", - "together", - "finally", - "would", - "benefit", + "starting", + "biology", + "rationally", "processes", - "heterodimeric", - "useful", - "provide", - "guaranteed", - "characterize", - "bring", - "complementary", - "vitro", + "points", "particularly", + "tested", "application", - "points", - "complementation", - "biophysics", + "synthetic", + "provide", + "good", + "library", + "complexity", + "characterize", + "crystallography", + "interactions", + "protein", + "useful", "relationships", - "design", + "function", + "bring", "reduced", - "characterization", + "modules", + "would", + "proteins", "helical", + "vitro", + "heterodimerize", + "cellular", + "characterization", + "pair", + "together", + "identify", + "coli", + "novo", + "cells", + "demonstrate", + "polypeptides", + "established", + "controllably", "transcription", - "synthetic", - "protein", - "interactions", - "rationally", + "guaranteed", + "benefit", + "components", + "homodimer", + "orthogonally", + "confirm", "applications", - "using", - "mammalian", - "complexity", + "exemplar", + "complementation", + "depend", "describe", "construct", - "function", - "pairs", - "cellular", - "good", - "hairpins", - "biology", - "homodimer", - "bimolecular", + "designs", "regulating", - "form", - "fluorescence", - "however", - "cells", - "polypeptides", - "heterodimerize", - "starting", - "depend", - "pair", - "subcellular", - "orthogonally" + "complementary", + "using", + "pairs", + "biophysics" ], "release_date":"2023-06-07", "publication":"\"Design and Selection of Heterodimerizing Helical Hairpins for Synthetic Biology\", Acs Synth Biol, 12, 1845-1858", @@ -593621,100 +596032,100 @@ ], "subtitle":"Racemic structure of pk-7 (310hd-u2u5)", "tags":[ + "aib", "de novo protein", - "alpha-helical", - "aib" + "alpha-helical" ], "keywords":[ - "work", - "stabilizing", - "frequently", - "acid", - "peptide", - "near", - "uses", - "crystal", - "exist", + "repeats", + "open", + "engineering", + "hydrophobic", + "structural", + "iterations", "show", - "features", - "rarely", - "interactions", - "synthetic", - "designing", - "consolidated", - "structure", - "unexplored", - "pack", - "principles", - "quaternary", - "tendencies", - "conformations", - "tend", - "built", + "acid", + "mean", + "folding", + "protein", + "six", "5", - "proteins", - "although", - "point", - "less", - "open", - "nature", - "3", - "structures", + "helical", + "incorporates", + "informed", + "region", "exceed", - "widely", - "natural", - "tertiary", - "biology", - "form", + "crystal", "rules", - "much", - "iterations", - "assemblies", - "report", - "bundles", - "energies", - "analysing", - "identify", - "1", - "4", "10", - "region", + "tertiary", + "conformational", + "bundles", + "supersecondary", + "stabilizing", + "opportunities", + "residues", + "hitherto", + "although", + "widely", + "quaternary", + "occur", + "favourable", "tipping", - "engineering", - "six", - "informed", - "provides", - "design", + "proteins", "characterization", - "incorporates", - "reduced", - "helical", - "occur", - "hydrophobic", + "2", + "energies", + "features", "required", - "favourable", - "repeats", - "exploited", - "hitherto", - "known", - "structural", - "despite", - "conformational", - "rational", + "1", + "peptide", + "normal", + "tend", + "designing", + "design", + "unexplored", "length", - "residues", - "reveal", - "supersecondary", + "work", + "principles", + "provides", + "biology", + "natural", "absence", - "normal", - "cores", - "protein", - "2", + "consolidated", + "point", + "reduced", + "uses", + "near", + "assemblies", + "exist", + "reveal", + "form", + "pack", + "analysing", "space", - "mean", - "folding", + "structures", + "built", + "rational", + "3", + "structure", + "synthetic", + "report", + "frequently", + "interactions", + "nature", + "known", + "4", "internal", - "opportunities" + "rarely", + "tendencies", + "identify", + "much", + "cores", + "conformations", + "despite", + "exploited", + "less" ], "release_date":"2022-11-23", "publication":"\"De novo design of discrete, stable 3 10 -helix peptide assemblies\", Nature, 607, 387-392", @@ -593812,101 +596223,101 @@ ], "subtitle":"A dimeric de novo coiled-coil assembly: pk-2 (cc-typen-laubucld)", "tags":[ - "de novo protein", - "alpha-helical", "aib", - "ll core" + "de novo protein", + "ll core", + "alpha-helical" ], "keywords":[ - "work", - "stabilizing", - "frequently", - "acid", - "peptide", - "near", - "uses", - "crystal", - "exist", + "repeats", + "open", + "engineering", + "hydrophobic", + "structural", + "iterations", "show", - "features", - "rarely", - "interactions", - "synthetic", - "designing", - "consolidated", - "structure", - "unexplored", - "pack", - "principles", - "quaternary", - "tendencies", - "conformations", - "tend", - "built", + "acid", + "mean", + "folding", + "protein", + "six", "5", - "proteins", - "although", - "point", - "less", - "open", - "nature", - "3", - "structures", + "helical", + "incorporates", + "informed", + "region", "exceed", - "widely", - "natural", - "tertiary", - "biology", - "form", + "crystal", "rules", - "much", - "iterations", - "assemblies", - "report", - "bundles", - "energies", - "analysing", - "identify", - "1", - "4", "10", - "region", + "tertiary", + "conformational", + "bundles", + "supersecondary", + "stabilizing", + "opportunities", + "residues", + "hitherto", + "although", + "widely", + "quaternary", + "occur", + "favourable", "tipping", - "engineering", - "six", - "informed", - "provides", - "design", + "proteins", "characterization", - "incorporates", - "reduced", - "helical", - "occur", - "hydrophobic", + "2", + "energies", + "features", "required", - "favourable", - "repeats", - "exploited", - "hitherto", - "known", - "structural", - "despite", - "conformational", - "rational", + "1", + "peptide", + "normal", + "tend", + "designing", + "design", + "unexplored", "length", - "residues", - "reveal", - "supersecondary", + "work", + "principles", + "provides", + "biology", + "natural", "absence", - "normal", - "cores", - "protein", - "2", + "consolidated", + "point", + "reduced", + "uses", + "near", + "assemblies", + "exist", + "reveal", + "form", + "pack", + "analysing", "space", - "mean", - "folding", + "structures", + "built", + "rational", + "3", + "structure", + "synthetic", + "report", + "frequently", + "interactions", + "nature", + "known", + "4", "internal", - "opportunities" + "rarely", + "tendencies", + "identify", + "much", + "cores", + "conformations", + "despite", + "exploited", + "less" ], "release_date":"2022-11-23", "publication":"\"De novo design of discrete, stable 3 10 -helix peptide assemblies\", Nature, 607, 387-392", @@ -594043,14 +596454,6 @@ } ], "seq_thr_sim_natural":[ - { - "sim":214.0, - "partner":"1w00" - }, - { - "sim":214.0, - "partner":"6c1x" - }, { "sim":214.0, "partner":"1e3r" @@ -594065,19 +596468,19 @@ }, { "sim":214.0, - "partner":"3cpo" + "partner":"6c17" }, { "sim":214.0, - "partner":"6c17" + "partner":"3cpo" }, { "sim":214.0, - "partner":"1cqs" + "partner":"2pzv" }, { "sim":214.0, - "partner":"2pzv" + "partner":"1cqs" }, { "sim":214.0, @@ -594101,19 +596504,15 @@ }, { "sim":214.0, - "partner":"3vsy" - }, - { - "sim":213.0, - "partner":"1vzz" + "partner":"6c1x" }, { - "sim":213.0, - "partner":"6tzd" + "sim":214.0, + "partner":"1w00" }, { - "sim":213.0, - "partner":"6ucn" + "sim":214.0, + "partner":"3vsy" }, { "sim":213.0, @@ -594159,6 +596558,18 @@ "sim":213.0, "partner":"7ry4" }, + { + "sim":213.0, + "partner":"1vzz" + }, + { + "sim":213.0, + "partner":"6tzd" + }, + { + "sim":213.0, + "partner":"6ucn" + }, { "sim":213.0, "partner":"5kp4" @@ -594233,15 +596644,15 @@ }, { "sim":210.0, - "partner":"1c7h" + "partner":"7rxk" }, { "sim":210.0, - "partner":"1dmn" + "partner":"1c7h" }, { "sim":210.0, - "partner":"7rxk" + "partner":"1dmn" }, { "sim":210.0, @@ -594309,11 +596720,11 @@ }, { "sim":68.0, - "partner":"3nuv" + "partner":"3m8c" }, { "sim":68.0, - "partner":"3m8c" + "partner":"3nuv" }, { "sim":68.0, @@ -594331,10 +596742,6 @@ "sim":68.0, "partner":"3nxj" }, - { - "sim":67.0, - "partner":"8cho" - }, { "sim":67.0, "partner":"3mki" @@ -594347,13 +596754,17 @@ "sim":67.0, "partner":"1ohp" }, + { + "sim":67.0, + "partner":"1qjg" + }, { "sim":67.0, "partner":"1buq" }, { "sim":67.0, - "partner":"1qjg" + "partner":"8cho" }, { "sim":66.0, @@ -594363,10 +596774,6 @@ "sim":65.0, "partner":"1ohs" }, - { - "sim":63.0, - "partner":"3mhe" - }, { "sim":63.0, "partner":"1ogz" @@ -594383,6 +596790,10 @@ "sim":63.0, "partner":"5dre" }, + { + "sim":63.0, + "partner":"3mhe" + }, { "sim":62.0, "partner":"3nm2" @@ -594411,10 +596822,6 @@ "sim":57.0, "partner":"6uae" }, - { - "sim":57.0, - "partner":"5hxu" - }, { "sim":57.0, "partner":"5hy1" @@ -594427,6 +596834,10 @@ "sim":57.0, "partner":"5hwe" }, + { + "sim":57.0, + "partner":"5hxu" + }, { "sim":56.0, "partner":"5x9j" @@ -594453,15 +596864,15 @@ }, { "sim":55.0, - "partner":"6edw" + "partner":"6edz" }, { "sim":55.0, - "partner":"6edz" + "partner":"6ee1" }, { "sim":55.0, - "partner":"6ee1" + "partner":"6edw" }, { "sim":54.0, @@ -594473,19 +596884,19 @@ }, { "sim":53.0, - "partner":"6suj" + "partner":"6slc" }, { "sim":53.0, - "partner":"6slc" + "partner":"6suj" }, { "sim":53.0, - "partner":"6isk" + "partner":"6isl" }, { "sim":53.0, - "partner":"6isl" + "partner":"6isk" }, { "sim":53.0, @@ -594529,15 +596940,15 @@ }, { "sim":52.0, - "partner":"3la7" + "partner":"3la2" }, { "sim":52.0, - "partner":"3la2" + "partner":"3la3" }, { "sim":52.0, - "partner":"3la3" + "partner":"3la7" }, { "sim":51.0, @@ -594585,19 +596996,19 @@ }, { "sim":51.0, - "partner":"6dcb" + "partner":"7slp" }, { "sim":51.0, - "partner":"6dcc" + "partner":"7slq" }, { "sim":51.0, - "partner":"7slp" + "partner":"6dcb" }, { "sim":51.0, - "partner":"7slq" + "partner":"6dcc" }, { "sim":51.0, @@ -594637,35 +597048,35 @@ }, { "sim":51.0, - "partner":"2y46" + "partner":"3zsn" }, { "sim":51.0, - "partner":"2y5n" + "partner":"2y98" }, { "sim":51.0, - "partner":"2yca" + "partner":"2y5z" }, { "sim":51.0, - "partner":"3zsn" + "partner":"4aw3" }, { "sim":51.0, - "partner":"2y98" + "partner":"2ygx" }, { "sim":51.0, - "partner":"2y5z" + "partner":"2y46" }, { "sim":51.0, - "partner":"4aw3" + "partner":"2y5n" }, { "sim":51.0, - "partner":"2ygx" + "partner":"2yca" }, { "sim":51.0, @@ -594725,51 +597136,51 @@ }, { "sim":50.0, - "partner":"3sie" + "partner":"4i9z" }, { "sim":50.0, - "partner":"4g2w" + "partner":"4ia0" }, { "sim":50.0, - "partner":"8w4s" + "partner":"4oew" }, { "sim":50.0, - "partner":"4g2y" + "partner":"4oex" }, { "sim":50.0, - "partner":"8w4t" + "partner":"6iwi" }, { "sim":50.0, - "partner":"4i9z" + "partner":"8w4s" }, { "sim":50.0, - "partner":"4ia0" + "partner":"8w4t" }, { "sim":50.0, - "partner":"4oew" + "partner":"3shy" }, { "sim":50.0, - "partner":"4oex" + "partner":"3shz" }, { "sim":50.0, - "partner":"6iwi" + "partner":"3sie" }, { "sim":50.0, - "partner":"3shy" + "partner":"4g2w" }, { "sim":50.0, - "partner":"3shz" + "partner":"4g2y" }, { "sim":50.0, @@ -594829,11 +597240,11 @@ }, { "sim":50.0, - "partner":"7tfc" + "partner":"8ovh" }, { "sim":50.0, - "partner":"8ovh" + "partner":"7tfc" }, { "sim":50.0, @@ -594867,7 +597278,7 @@ }, "seq_max_sim_natural":{ "sim":214.0, - "partner":"1w00" + "partner":"1e3r" }, "struct_max_sim_designed":{ "sim":0.9546999931, @@ -594917,96 +597328,96 @@ ], "subtitle":"De novo single-chain immunoglobulin dimer scig12+ef3a", "tags":[ - "single-chain dimer", + "de novo", "immunoglobulin", - "beta", - "ef-hand", "de novo protein", + "beta", "sandwich", - "de novo" + "single-chain dimer", + "ef-hand" ], "keywords":[ - "results", - "recapitulate", - "architecture", + "dimers", + "engineering", + "limited", + "hyperstable", + "number", + "hard", "multiple", + "positioning", "route", + "assays", + "results", + "accommodating", + "tailoring", + "protein", "biochemical", - "scaffolds", - "crystallography", - "designed", + "accurate", + "binding", + "guided", + "confirmed", + "novo", + "two", + "applications", + "modify", + "possibility", "robust", - "provide", - "improved", - "limited", - "designing", - "tailoring", - "structure", - "structurally", - "hard", - "computationally", - "favorable", + "occurring", "however", - "principles", - "therapeutic", - "derivatives", - "interfaces", - "de", "hypervariable", - "immunoglobulin", - "optimizes", - "number", - "assays", - "orientation", - "occurring", + "dimer", + "computationally", + "showcase", + "epitopes", + "relative", + "architecture", + "success", + "tunable", + "combination", + "designing", + "individually", + "convenient", + "principles", "geometrical", - "modularity", - "naturally", "research", - "targeting", - "devise", - "properties", "loops", "functional", - "harboring", - "antigen", - "opening", - "antibody", - "accurate", - "approaches", - "dimer", - "engineering", + "derivatives", + "properties", + "targeting", "distal", - "applications", - "epitopes", - "individually", + "orientation", + "therapeutic", + "improved", + "modularity", + "devise", "diversification", - "guided", - "showcase", - "one", - "positioning", - "novo", - "success", - "possibility", - "convenient", - "confirmed", + "harboring", + "designed", "displaying", - "two", - "dimers", - "modify", + "naturally", + "interfaces", + "opening", + "one", "sought", - "accommodating", - "protein", - "hyperstable", + "structurally", + "recapitulate", + "traditional", + "de", + "approaches", + "structure", + "antigen", + "scaffolds", + "provide", + "crystallography", + "biophysical", "attributes", - "combination", + "optimizes", "diagnostic", - "tunable", + "favorable", + "immunoglobulin", "antibodies", - "relative", - "binding", - "biophysical", - "traditional" + "antibody" ], "release_date":"2023-10-04", "publication":"\"Single-chain dimers from de novo immunoglobulins as robust scaffolds for multiple binding loops\", Nat Commun, 14, 5939-5939", @@ -595077,11 +597488,11 @@ }, { "sim":58.0, - "partner":"8u2x" + "partner":"6xdh" }, { "sim":58.0, - "partner":"6xdh" + "partner":"8u2x" }, { "sim":57.0, @@ -595169,15 +597580,15 @@ }, { "sim":51.0, - "partner":"7e15" + "partner":"5ghr" }, { "sim":51.0, - "partner":"5ghr" + "partner":"5ghs" }, { "sim":51.0, - "partner":"5ghs" + "partner":"7e15" }, { "sim":51.0, @@ -595197,19 +597608,19 @@ }, { "sim":51.0, - "partner":"3lvy" + "partner":"2evv" }, { "sim":51.0, - "partner":"2evv" + "partner":"3lvy" }, { "sim":51.0, - "partner":"7ed6" + "partner":"7ed9" }, { "sim":51.0, - "partner":"7ed9" + "partner":"7ed6" }, { "sim":51.0, @@ -595241,15 +597652,15 @@ }, { "sim":51.0, - "partner":"7zke" + "partner":"7z7n" }, { "sim":51.0, - "partner":"7z7n" + "partner":"7z8s" }, { "sim":51.0, - "partner":"7z8s" + "partner":"7zke" }, { "sim":51.0, @@ -595315,14 +597726,6 @@ "sim":51.0, "partner":"2x7j" }, - { - "sim":51.0, - "partner":"4q4e" - }, - { - "sim":51.0, - "partner":"3b34" - }, { "sim":51.0, "partner":"3ked" @@ -595383,6 +597786,14 @@ "sim":51.0, "partner":"3qjx" }, + { + "sim":51.0, + "partner":"4q4e" + }, + { + "sim":51.0, + "partner":"3b34" + }, { "sim":50.0, "partner":"4lge" @@ -595425,11 +597836,11 @@ }, { "sim":50.0, - "partner":"3zpc" + "partner":"3zpg" }, { "sim":50.0, - "partner":"3zpg" + "partner":"3zpc" } ], "struct_thr_sim_designed":[ @@ -595534,7 +597945,7 @@ "seq_thr_sim_natural":[ { "sim":216.0, - "partner":"1w00" + "partner":"3fzw" }, { "sim":216.0, @@ -595542,7 +597953,7 @@ }, { "sim":216.0, - "partner":"3fzw" + "partner":"1w00" }, { "sim":216.0, @@ -595562,19 +597973,19 @@ }, { "sim":215.0, - "partner":"3cpo" + "partner":"6c17" }, { "sim":215.0, - "partner":"6c17" + "partner":"3cpo" }, { "sim":215.0, - "partner":"1cqs" + "partner":"2pzv" }, { "sim":215.0, - "partner":"2pzv" + "partner":"1cqs" }, { "sim":215.0, @@ -595596,18 +598007,6 @@ "sim":215.0, "partner":"3vgn" }, - { - "sim":214.0, - "partner":"1vzz" - }, - { - "sim":214.0, - "partner":"6tzd" - }, - { - "sim":214.0, - "partner":"6ucn" - }, { "sim":214.0, "partner":"1w02" @@ -595652,6 +598051,18 @@ "sim":214.0, "partner":"7ry4" }, + { + "sim":214.0, + "partner":"1vzz" + }, + { + "sim":214.0, + "partner":"6tzd" + }, + { + "sim":214.0, + "partner":"6ucn" + }, { "sim":214.0, "partner":"5kp4" @@ -595686,11 +598097,11 @@ }, { "sim":213.0, - "partner":"1w6y" + "partner":"7rxf" }, { "sim":213.0, - "partner":"7rxf" + "partner":"1w6y" }, { "sim":212.0, @@ -595730,7 +598141,7 @@ }, { "sim":211.0, - "partner":"1dmn" + "partner":"7rxk" }, { "sim":211.0, @@ -595738,7 +598149,7 @@ }, { "sim":211.0, - "partner":"7rxk" + "partner":"1dmn" }, { "sim":211.0, @@ -595798,16 +598209,12 @@ }, { "sim":64.0, - "partner":"8cho" + "partner":"3m8c" }, { "sim":64.0, "partner":"3nuv" }, - { - "sim":64.0, - "partner":"3m8c" - }, { "sim":64.0, "partner":"3mki" @@ -595826,15 +598233,15 @@ }, { "sim":64.0, - "partner":"1buq" + "partner":"3nhx" }, { "sim":64.0, - "partner":"3nhx" + "partner":"1qjg" }, { "sim":64.0, - "partner":"1qjg" + "partner":"1buq" }, { "sim":64.0, @@ -595844,6 +598251,10 @@ "sim":64.0, "partner":"3nxj" }, + { + "sim":64.0, + "partner":"8cho" + }, { "sim":63.0, "partner":"6uad" @@ -595852,10 +598263,6 @@ "sim":62.0, "partner":"1ohs" }, - { - "sim":60.0, - "partner":"3mhe" - }, { "sim":60.0, "partner":"3nbr" @@ -595868,6 +598275,10 @@ "sim":60.0, "partner":"5dre" }, + { + "sim":60.0, + "partner":"3mhe" + }, { "sim":59.0, "partner":"1ogz" @@ -595896,10 +598307,6 @@ "sim":58.0, "partner":"3ov4" }, - { - "sim":57.0, - "partner":"5hxu" - }, { "sim":57.0, "partner":"5hy1" @@ -595912,6 +598319,10 @@ "sim":57.0, "partner":"5hwe" }, + { + "sim":57.0, + "partner":"5hxu" + }, { "sim":56.0, "partner":"5x9j" @@ -595950,23 +598361,23 @@ }, { "sim":54.0, - "partner":"6edw" + "partner":"6edz" }, { "sim":54.0, - "partner":"6edz" + "partner":"6ee1" }, { "sim":54.0, - "partner":"6ee1" + "partner":"6edw" }, { "sim":53.0, - "partner":"6isk" + "partner":"6isl" }, { "sim":53.0, - "partner":"6isl" + "partner":"6isk" }, { "sim":53.0, @@ -596010,15 +598421,15 @@ }, { "sim":52.0, - "partner":"3la7" + "partner":"3la2" }, { "sim":52.0, - "partner":"3la2" + "partner":"3la3" }, { "sim":52.0, - "partner":"3la3" + "partner":"3la7" }, { "sim":51.0, @@ -596066,19 +598477,19 @@ }, { "sim":51.0, - "partner":"6dcb" + "partner":"7slp" }, { "sim":51.0, - "partner":"6dcc" + "partner":"7slq" }, { "sim":51.0, - "partner":"7slp" + "partner":"6dcb" }, { "sim":51.0, - "partner":"7slq" + "partner":"6dcc" }, { "sim":51.0, @@ -596094,35 +598505,35 @@ }, { "sim":51.0, - "partner":"2y46" + "partner":"3zsn" }, { "sim":51.0, - "partner":"2y5n" + "partner":"2y98" }, { "sim":51.0, - "partner":"2yca" + "partner":"2y5z" }, { "sim":51.0, - "partner":"3zsn" + "partner":"4aw3" }, { "sim":51.0, - "partner":"2y98" + "partner":"2ygx" }, { "sim":51.0, - "partner":"2y5z" + "partner":"2y46" }, { "sim":51.0, - "partner":"4aw3" + "partner":"2y5n" }, { "sim":51.0, - "partner":"2ygx" + "partner":"2yca" }, { "sim":51.0, @@ -596178,15 +598589,15 @@ }, { "sim":50.0, - "partner":"6suj" + "partner":"2gwf" }, { "sim":50.0, - "partner":"2gwf" + "partner":"6slc" }, { "sim":50.0, - "partner":"6slc" + "partner":"6suj" }, { "sim":50.0, @@ -596230,51 +598641,51 @@ }, { "sim":50.0, - "partner":"3sie" + "partner":"4i9z" }, { "sim":50.0, - "partner":"4g2w" + "partner":"4ia0" }, { "sim":50.0, - "partner":"8w4s" + "partner":"4oew" }, { "sim":50.0, - "partner":"4g2y" + "partner":"4oex" }, { "sim":50.0, - "partner":"8w4t" + "partner":"6iwi" }, { "sim":50.0, - "partner":"4i9z" + "partner":"8w4s" }, { "sim":50.0, - "partner":"4ia0" + "partner":"8w4t" }, { "sim":50.0, - "partner":"4oew" + "partner":"3shy" }, { "sim":50.0, - "partner":"4oex" + "partner":"3shz" }, { "sim":50.0, - "partner":"6iwi" + "partner":"3sie" }, { "sim":50.0, - "partner":"3shy" + "partner":"4g2w" }, { "sim":50.0, - "partner":"3shz" + "partner":"4g2y" }, { "sim":50.0, @@ -596334,11 +598745,11 @@ }, { "sim":50.0, - "partner":"7tfc" + "partner":"8ovh" }, { "sim":50.0, - "partner":"8ovh" + "partner":"7tfc" }, { "sim":50.0, @@ -596364,7 +598775,7 @@ }, "seq_max_sim_natural":{ "sim":216.0, - "partner":"1w00" + "partner":"3fzw" }, "struct_max_sim_designed":{ "sim":0.953700006, @@ -596418,86 +598829,86 @@ ], "subtitle":"Crystal structure of an 8 repeat consensus tpr superhelix with calcium", "tags":[ - "metal coordination", - "ctpr", + "polymorphism", "de novo protein", - "polymorphism" + "metal coordination", + "ctpr" ], "keywords":[ - "facile", + "form", + "crystalline", + "engineering", + "calculations", + "pofs", + "allow", + "controlled", + "responsible", + "presents", + "metal", + "negatively", + "opening", + "exposed", + "thermodynamically", + "repeat", "diverse", - "scope", - "obtained", - "density", - "despite", + "comparison", + "structurally", + "requirements", "salts", - "amino", - "proteins", + "single", + "porosity", "functional", - "frameworks", + "kinetically", + "polymorphic", "thus", - "coordination", - "presents", - "assemblies", - "pofs", - "strategy", - "single", - "stable", - "metal", - "cluster", - "calculations", - "opening", - "scaffolds", + "application", + "residues", + "preferences", + "controllable", "acid", - "negatively", - "polymorphs", - "trapped", + "scaffolds", + "addition", "finding", - "controlled", - "polymorphic", - "allow", - "residues", - "abundance", - "tetratricopeptide", + "diversity", + "strategy", + "new", + "frameworks", + "ion", + "protein", + "trapped", + "polymorphism", + "amino", "exploiting", - "direct", - "crystal", - "engineering", - "geometric", + "proteins", + "tetratricopeptide", + "achieved", + "cluster", + "polymorphs", "innate", - "kinetically", - "application", - "addition", - "polymorphism", - "increasingly", - "comparison", - "protein", - "controllable", - "biocompatible", - "applications", - "states", - "requirements", - "negative", - "charged", - "theory", - "structurally", - "responsible", - "repeat", "showed", - "diversity", - "thermodynamically", - "minimal", "varying", - "crystalline", - "form", - "porosity", - "achieved", - "preferences", - "exposed", + "direct", "consensus", + "coordination", + "charged", + "biocompatible", + "negative", + "states", + "scope", "crystals", - "ion", - "new" + "increasingly", + "density", + "despite", + "applications", + "crystal", + "stable", + "theory", + "assemblies", + "minimal", + "abundance", + "obtained", + "geometric", + "facile" ], "release_date":"2023-12-13", "publication":"\"Diverse crystalline protein scaffolds through metal-dependent polymorphism\", Protein Sci., 33, e4971-e4971", @@ -596530,15 +598941,15 @@ "seq_thr_sim_designed":[ { "sim":622.0, - "partner":"8cqq" + "partner":"8ckr" }, { "sim":622.0, - "partner":"8ot7" + "partner":"8cqp" }, { "sim":622.0, - "partner":"8chy" + "partner":"8ot7" }, { "sim":622.0, @@ -596546,19 +598957,19 @@ }, { "sim":622.0, - "partner":"8ckr" + "partner":"8cp8" }, { "sim":622.0, - "partner":"8cig" + "partner":"8cqq" }, { "sim":622.0, - "partner":"8cqp" + "partner":"8chy" }, { "sim":622.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":303.0, @@ -596598,11 +599009,11 @@ }, { "sim":136.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":136.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":127.0, @@ -596618,15 +599029,15 @@ }, { "sim":94.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":94.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":94.0, - "partner":"8cus" + "partner":"8cwz" } ], "seq_thr_sim_natural":[ @@ -596658,10 +599069,6 @@ "sim":178.0, "partner":"7y4i" }, - { - "sim":178.0, - "partner":"8dtf" - }, { "sim":178.0, "partner":"8dtg" @@ -596674,6 +599081,10 @@ "sim":178.0, "partner":"8dti" }, + { + "sim":178.0, + "partner":"8dtf" + }, { "sim":164.0, "partner":"7kna" @@ -596712,23 +599123,23 @@ }, { "sim":139.0, - "partner":"7ep7" + "partner":"4g2v" }, { "sim":139.0, - "partner":"4g2v" + "partner":"7ep7" }, { "sim":138.0, - "partner":"8a5y" + "partner":"8a3t" }, { "sim":138.0, - "partner":"8a3t" + "partner":"8a61" }, { "sim":138.0, - "partner":"8a61" + "partner":"8a5y" }, { "sim":136.0, @@ -596742,10 +599153,6 @@ "sim":131.0, "partner":"6xt9" }, - { - "sim":130.0, - "partner":"4rg6" - }, { "sim":130.0, "partner":"4rg7" @@ -596756,11 +599163,7 @@ }, { "sim":130.0, - "partner":"5lcw" - }, - { - "sim":130.0, - "partner":"6q6g" + "partner":"4rg6" }, { "sim":130.0, @@ -596784,16 +599187,12 @@ }, { "sim":130.0, - "partner":"8pkp" + "partner":"6tlj" }, { "sim":130.0, "partner":"5l9u" }, - { - "sim":130.0, - "partner":"6tlj" - }, { "sim":130.0, "partner":"6q6h" @@ -596806,6 +599205,10 @@ "sim":130.0, "partner":"5a31" }, + { + "sim":130.0, + "partner":"8pkp" + }, { "sim":130.0, "partner":"5g05" @@ -596818,25 +599221,33 @@ "sim":130.0, "partner":"4ui9" }, + { + "sim":130.0, + "partner":"6q6g" + }, { "sim":130.0, "partner":"8tau" }, + { + "sim":130.0, + "partner":"5lcw" + }, { "sim":125.0, - "partner":"6voa" + "partner":"6vbu" }, { "sim":125.0, - "partner":"6vnw" + "partner":"6vbv" }, { "sim":125.0, - "partner":"6vbu" + "partner":"6voa" }, { "sim":125.0, - "partner":"6vbv" + "partner":"6vnw" }, { "sim":122.0, @@ -596862,22 +599273,6 @@ "sim":107.0, "partner":"6tka" }, - { - "sim":106.0, - "partner":"4xif" - }, - { - "sim":106.0, - "partner":"8fe7" - }, - { - "sim":106.0, - "partner":"4gyw" - }, - { - "sim":106.0, - "partner":"5vif" - }, { "sim":106.0, "partner":"4xi9" @@ -596918,6 +599313,10 @@ "sim":106.0, "partner":"5c1d" }, + { + "sim":106.0, + "partner":"6ma1" + }, { "sim":106.0, "partner":"3pe4" @@ -596940,15 +599339,15 @@ }, { "sim":106.0, - "partner":"6ma1" + "partner":"6ma2" }, { "sim":106.0, - "partner":"4n3c" + "partner":"8fe6" }, { "sim":106.0, - "partner":"6ma2" + "partner":"4n3c" }, { "sim":106.0, @@ -596956,7 +599355,7 @@ }, { "sim":106.0, - "partner":"8fe6" + "partner":"8fuf" }, { "sim":106.0, @@ -596968,7 +599367,11 @@ }, { "sim":106.0, - "partner":"8fuf" + "partner":"8cm9" + }, + { + "sim":106.0, + "partner":"6ma5" }, { "sim":106.0, @@ -596976,11 +599379,15 @@ }, { "sim":106.0, - "partner":"8cm9" + "partner":"8fe7" }, { "sim":106.0, - "partner":"6ma5" + "partner":"6ibo" + }, + { + "sim":106.0, + "partner":"6q4m" }, { "sim":106.0, @@ -596988,11 +599395,15 @@ }, { "sim":106.0, - "partner":"6ibo" + "partner":"4xif" }, { "sim":106.0, - "partner":"6q4m" + "partner":"4gyw" + }, + { + "sim":106.0, + "partner":"5vif" }, { "sim":105.0, @@ -597050,10 +599461,6 @@ "sim":87.0, "partner":"2c0m" }, - { - "sim":87.0, - "partner":"4kyo" - }, { "sim":87.0, "partner":"3r9a" @@ -597066,6 +599473,10 @@ "sim":87.0, "partner":"4kxk" }, + { + "sim":87.0, + "partner":"4kyo" + }, { "sim":87.0, "partner":"1fch" @@ -597272,11 +599683,11 @@ }, { "sim":70.0, - "partner":"5w5i" + "partner":"5w5h" }, { "sim":70.0, - "partner":"5w5h" + "partner":"5w5i" }, { "sim":69.0, @@ -597336,11 +599747,11 @@ }, { "sim":59.0, - "partner":"7qws" + "partner":"6t59" }, { "sim":59.0, - "partner":"6t59" + "partner":"7qws" }, { "sim":59.0, @@ -597396,11 +599807,11 @@ }, { "sim":58.0, - "partner":"4i9e" + "partner":"3ulq" }, { "sim":58.0, - "partner":"3ulq" + "partner":"4i9e" }, { "sim":57.0, @@ -597516,11 +599927,11 @@ }, { "sim":55.0, - "partner":"8hmc" + "partner":"8hmd" }, { "sim":55.0, - "partner":"8hmd" + "partner":"8hmc" }, { "sim":54.0, @@ -597576,11 +599987,11 @@ }, { "sim":52.0, - "partner":"6fdp" + "partner":"6fdt" }, { "sim":52.0, - "partner":"6fdt" + "partner":"6fdp" }, { "sim":52.0, @@ -597654,7 +600065,7 @@ ], "seq_max_sim_designed":{ "sim":622.0, - "partner":"8cqq" + "partner":"8ckr" }, "seq_max_sim_natural":{ "sim":233.0, @@ -597724,11 +600135,11 @@ ], "subtitle":"Engineered mini-protein lcb2 (blocking ligand of sars-cov-2 spike protein)", "tags":[ - "antiviral", "mini-protein", + "sars-cov-2", + "antiviral", "blocking ligand", - "antiviral protein", - "sars-cov-2" + "antiviral protein" ], "keywords":[ "description", @@ -597782,11 +600193,11 @@ ], "struct_max_sim_designed":{ - "sim":0.7983000278, + "sim":0.798699975, "partner":"8uos" }, "struct_max_sim_natural":{ - "sim":0.8276000023, + "sim":0.8342999816, "partner":"4d18" }, "review_comment":[ @@ -597854,125 +600265,125 @@ ], "subtitle":"Crystal structure of a computationally designed heme binding protein, dnhem1", "tags":[ - "heme binding protein", "computational design", "de novo protein", + "heme binding protein", "biosynthetic protein" ], "keywords":[ - "cyclopropanation", - "hence", - "containing", - "intermediate", - "porphyrin", - "scaffolds", - "atom", - "programmed", - "broad", + "highlighted", + "open", + "turnovers", + "limited", + "customizability", + "prowess", + "key", + "combining", "substitutions", - "shapes", + "heme", "cofactors", - "parallel", + "model", + "protein", + "activities", + "pockets", + "reconfiguring", + "helical", + "pentacoordinated", + "binding", + "coordination", + "site", + "novo", + "axial", + "catalytic", + "variety", "crystal", - "proficient", - "limited", - "features", - "93", - "position", - "bind", - "structure", - "intended", - "however", - "reactive", + "stable", "isolated", - "combining", - "generating", - "excellent", - "incorporation", - "neutral", - "models", - "coordination", - "redesigned", + "carbene", + "adjacent", + "5000", + "goal", + "transferases", + "p450s", + "enantiocomplementary", "enables", - "de", - "enzymes", - "ferryl", - "\u00e5", - "pentacoordinated", + "engineered", + "proficient", + "however", + "efforts", + "agreement", "almost", - "reconfiguring", - "goal", - "open", - "substrate", - "peroxidase", - "site", - "dnhem1", - "customizability", - "highlighted", - "calculated", - "converted", - "natural", - "pockets", "intermediates", + "inspired", + "ligand", + "dnhem1", + "accessible", "transition", - "styrene", - "carbene", - "unlimited", - "transformations", + "vacant", + "intended", + "bind", + "approach", + "calculated", "large", - "reveals", - "enantiocomplementary", + "broad", + "cytochrome", + "enzymes", + "shapes", + "tunable", "chemical", - "geometry", - "generate", - "catalytic", - "activities", - "p450s", - "agreement", - "vacant", + "peroxidase", + "incorporation", + "features", "bundle", + "lack", + "pocket", "design", - "model", + "redesigned", + "accommodate", + "natural", + "coordinating", + "substrate", + "hence", "distal", - "helical", - "histidine", - "key", - "versatility", + "atom", + "93", + "cyclopropanation", "functionalities", + "parallel", + "reveals", + "reactive", + "excellent", + "generating", "range", - "designs", - "ligand", - "p450", - "accessible", - "lack", - "approach", - "novo", "cofactor", - "efforts", - "stable", - "axial", - "heme", - "engineered", - "prowess", + "central", + "models", "custom", - "transferases", - "adjacent", - "turnovers", - "cytochrome", + "histidine", + "geometry", + "unlimited", + "de", + "\u00e5", + "p450", + "structure", + "scaffolds", "state", - "central", - "iron", - "binding", - "protein", + "ferryl", "yield", - "variety", - "5000", - "tunable", - "inspired", - "accommodate", - "pocket", + "neutral", + "intermediate", + "programmed", + "transformations", "advantages", - "coordinating" + "position", + "converted", + "porphyrin", + "iron", + "versatility", + "designs", + "containing", + "generate", + "styrene" ], "release_date":"2023-07-05", "publication":"\"Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site\", J.Am.Chem.Soc., 145, 14307-14315", @@ -598066,13 +600477,29 @@ "forename":"K.", "surname":"Myrtollari" }, + { + "forename":"E.", + "surname":"Calderini" + }, { "forename":"D.", "surname":"Kracher" }, { - "forename":"E.", - "surname":"Calderini" + "forename":"T.", + "surname":"Schongassner" + }, + { + "forename":"S.", + "surname":"Galusic" + }, + { + "forename":"A.", + "surname":"Slavica" + }, + { + "forename":"A.", + "surname":"Taden" }, { "forename":"D.", @@ -598080,7 +600507,7 @@ }, { "forename":"A.", - "surname":"Schruefer" + "surname":"Schrufer" }, { "forename":"G.", @@ -598108,26 +600535,129 @@ ], "subtitle":"Structure of the reconstructed ancestor of phenolic acid decarboxylase ancpad55", "tags":[ + "lyase", "phenolic acid decarboxylase", "ancestral sequence reconstruction", - "ancestor", - "lyase" + "ancestor" ], "keywords":[ - "description", - "found" + "organic", + "hydrophobic", + "structural", + "key", + "number", + "thermostable", + "reduce", + "three", + "hydroxycinnamic", + "acid", + "regression", + "candidates", + "study", + "accumulation", + "salt", + "stabilization", + "unfolding", + "predicting", + "straightforward", + "systems", + "crystal", + "stable", + "total", + "aqueous", + "deep", + "phenolic", + "proficient", + "experimentally", + "access", + "pool", + "selected", + "thus", + "bridges", + "gives", + "solvents", + "eutectic", + "thermal", + "makes", + "stability", + "approach", + "waste", + "calculated", + "proteins", + "achieved", + "process", + "ancestral", + "enzymes", + "hydrogen", + "enzyme", + "option", + "adhesive", + "biocatalyst", + "set", + "increase", + "surface", + "energy", + "biphasic", + "fit", + "used", + "feature", + "natural", + "yet", + "different", + "clusters", + "16", + "properties", + "application", + "variant", + "bonds", + "enhancing", + "turnover", + "explored", + "industrial", + "resulted", + "ancestors", + "buffers", + "time", + "applied", + "sequence", + "associated", + "production", + "consumption", + "models", + "h", + "identification", + "variants", + "structures", + "reconstruction", + "mixtures", + "enzymatic", + "styrenes", + "rely", + "determined", + "temperature", + "would", + "investigation", + "identify", + "45", + "decarboxylation", + "attributes", + "60", + "acids", + "decarboxylases", + "biobased", + "generate" ], "release_date":"2023-07-19", - "publication":"To be published", + "publication":"\"Stability Increase of Phenolic Acid Decarboxylase by a Combination of Protein and Solvent Engineering Unlocks Applications at Elevated Temperatures\", Acs Sustain Chem Eng, 12, 3575-3584", "publication_ref":{ - "DOI":"", - "PubMed":"", + "DOI":"10.1021\/acssuschemeng.3c06513", + "PubMed":"38456190", "CSD":"", - "ISSN":"", + "ISSN":"2168-0485", "ASTM":"" }, - "publication_country":"", - "abstract":"No description found.", + "publication_country":"US", + "abstract":"Enzymatic decarboxylation of biobased hydroxycinnamic acids gives access to phenolic styrenes for adhesive production. Phenolic acid decarboxylases are proficient enzymes that have been applied in aqueous systems, organic solvents, biphasic systems, and deep eutectic solvents, which makes stability a key feature. Stabilization of the enzyme would increase the total turnover number and thus reduce the energy consumption and waste accumulation associated with biocatalyst production. In this study, we used ancestral sequence reconstruction to generate thermostable decarboxylases. Investigation of a set of 16 ancestors resulted in the identification of a variant with an unfolding temperature of 78.1 \u00b0C and a half-life time of 45 h at 60 \u00b0C. Crystal structures were determined for three selected ancestors. Structural attributes were calculated to fit different regression models for predicting the thermal stability of variants that have not yet been experimentally explored. The models rely on hydrophobic clusters, salt bridges, hydrogen bonds, and surface properties and can identify more stable proteins out of a pool of candidates. Further stabilization was achieved by the application of mixtures of natural deep eutectic solvents and buffers. Our approach is a straightforward option for enhancing the industrial application of the decarboxylation process.", "crystal_structure":{ "length_a":"57.999", "length_b":"105.274", @@ -598156,19 +600686,19 @@ }, { "sim":51.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":51.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":51.0, - "partner":"8w08" + "partner":"8w06" }, { "sim":51.0, - "partner":"8w05" + "partner":"8v0a" }, { "sim":50.0, @@ -598238,28 +600768,12 @@ }, { "sim":58.0, - "partner":"4wya" - }, - { - "sim":58.0, - "partner":"4wyf" - }, - { - "sim":58.0, - "partner":"4cxq" - }, - { - "sim":58.0, - "partner":"5kgs" + "partner":"4cxr" }, { "sim":58.0, "partner":"4wyg" }, - { - "sim":58.0, - "partner":"4cxr" - }, { "sim":58.0, "partner":"4xjl" @@ -598324,25 +600838,33 @@ "sim":58.0, "partner":"3tfu" }, + { + "sim":58.0, + "partner":"4wya" + }, { "sim":58.0, "partner":"4wye" }, { - "sim":57.0, - "partner":"7p4y" + "sim":58.0, + "partner":"4wyf" }, { - "sim":57.0, - "partner":"7p50" + "sim":58.0, + "partner":"4cxq" + }, + { + "sim":58.0, + "partner":"5kgs" }, { "sim":57.0, - "partner":"5y0f" + "partner":"7p50" }, { "sim":57.0, - "partner":"5y0g" + "partner":"7p4y" }, { "sim":57.0, @@ -598354,27 +600876,27 @@ }, { "sim":57.0, - "partner":"5y12" + "partner":"6ljs" }, { "sim":57.0, - "partner":"6ljs" + "partner":"6ljt" }, { "sim":57.0, - "partner":"5d45" + "partner":"5y12" }, { "sim":57.0, - "partner":"5y13" + "partner":"6lju" }, { "sim":57.0, - "partner":"6ljt" + "partner":"5d45" }, { "sim":57.0, - "partner":"6lju" + "partner":"5y13" }, { "sim":57.0, @@ -598404,6 +600926,14 @@ "sim":57.0, "partner":"5y0x" }, + { + "sim":57.0, + "partner":"5y0f" + }, + { + "sim":57.0, + "partner":"5y0g" + }, { "sim":57.0, "partner":"4urs" @@ -598486,16 +601016,12 @@ }, { "sim":56.0, - "partner":"5uw0" + "partner":"5uw1" }, { "sim":56.0, "partner":"5vnc" }, - { - "sim":56.0, - "partner":"5uw1" - }, { "sim":56.0, "partner":"5uw4" @@ -598506,7 +601032,7 @@ }, { "sim":56.0, - "partner":"3rsz" + "partner":"5uw0" }, { "sim":56.0, @@ -598538,35 +601064,39 @@ }, { "sim":56.0, - "partner":"3ahc" + "partner":"3rsz" }, { "sim":56.0, - "partner":"3ahd" + "partner":"3ahf" }, { "sim":56.0, - "partner":"3ahe" + "partner":"3ahg" }, { "sim":56.0, - "partner":"3ahf" + "partner":"3ahh" }, { "sim":56.0, - "partner":"3ahg" + "partner":"3ahi" }, { "sim":56.0, - "partner":"3ahh" + "partner":"3ahj" }, { "sim":56.0, - "partner":"3ahi" + "partner":"3ahc" }, { "sim":56.0, - "partner":"3ahj" + "partner":"3ahd" + }, + { + "sim":56.0, + "partner":"3ahe" }, { "sim":55.0, @@ -598578,11 +601108,11 @@ }, { "sim":55.0, - "partner":"1wc6" + "partner":"1wc1" }, { "sim":55.0, - "partner":"1wc1" + "partner":"1wc6" }, { "sim":55.0, @@ -598626,11 +601156,11 @@ }, { "sim":55.0, - "partner":"8hsv" + "partner":"8hst" }, { "sim":55.0, - "partner":"8hst" + "partner":"8hsv" }, { "sim":55.0, @@ -598760,10 +601290,6 @@ "sim":54.0, "partner":"4nec" }, - { - "sim":54.0, - "partner":"5nbp" - }, { "sim":54.0, "partner":"7kr6" @@ -598776,6 +601302,10 @@ "sim":54.0, "partner":"5nbo" }, + { + "sim":54.0, + "partner":"5nbp" + }, { "sim":54.0, "partner":"8arv" @@ -598812,10 +601342,6 @@ "sim":54.0, "partner":"2b4u" }, - { - "sim":54.0, - "partner":"2pt0" - }, { "sim":54.0, "partner":"3d1o" @@ -598838,11 +601364,11 @@ }, { "sim":54.0, - "partner":"4ot7" + "partner":"2pt0" }, { "sim":54.0, - "partner":"6put" + "partner":"4ot7" }, { "sim":54.0, @@ -598856,13 +601382,17 @@ "sim":54.0, "partner":"6v3k" }, + { + "sim":54.0, + "partner":"6puz" + }, { "sim":54.0, "partner":"5u1c" }, { "sim":54.0, - "partner":"6puz" + "partner":"6put" }, { "sim":54.0, @@ -598906,11 +601436,11 @@ }, { "sim":53.0, - "partner":"7u0u" + "partner":"7d7d" }, { "sim":53.0, - "partner":"7d7d" + "partner":"7u0u" }, { "sim":53.0, @@ -599000,10 +601530,6 @@ "sim":53.0, "partner":"2f17" }, - { - "sim":53.0, - "partner":"4yvk" - }, { "sim":53.0, "partner":"8apt" @@ -599046,7 +601572,7 @@ }, { "sim":53.0, - "partner":"4jyi" + "partner":"4yvk" }, { "sim":53.0, @@ -599072,6 +601598,10 @@ "sim":53.0, "partner":"4jyh" }, + { + "sim":53.0, + "partner":"4jyi" + }, { "sim":53.0, "partner":"6szg" @@ -599172,10 +601702,6 @@ "sim":53.0, "partner":"4s2c" }, - { - "sim":53.0, - "partner":"4d2w" - }, { "sim":53.0, "partner":"4d2p" @@ -599208,6 +601734,10 @@ "sim":53.0, "partner":"4d2v" }, + { + "sim":53.0, + "partner":"4d2w" + }, { "sim":53.0, "partner":"4hty" @@ -599224,10 +601754,6 @@ "sim":53.0, "partner":"7qwt" }, - { - "sim":53.0, - "partner":"3pz9" - }, { "sim":53.0, "partner":"3pzg" @@ -599254,7 +601780,7 @@ }, { "sim":53.0, - "partner":"5hxu" + "partner":"3pz9" }, { "sim":53.0, @@ -599268,6 +601794,10 @@ "sim":53.0, "partner":"5hwe" }, + { + "sim":53.0, + "partner":"5hxu" + }, { "sim":53.0, "partner":"3vax" @@ -599350,79 +601880,79 @@ }, { "sim":53.0, - "partner":"8gf0" + "partner":"7lam" }, { "sim":53.0, - "partner":"8gfp" + "partner":"8gfb" }, { "sim":53.0, - "partner":"8gf1" + "partner":"8gfc" }, { "sim":53.0, - "partner":"8gfq" + "partner":"8gfd" }, { "sim":53.0, - "partner":"8gfs" + "partner":"8gfe" }, { "sim":53.0, - "partner":"7lam" + "partner":"7laq" }, { "sim":53.0, - "partner":"7laq" + "partner":"8gff" }, { "sim":53.0, - "partner":"8gfb" + "partner":"8gfg" }, { "sim":53.0, - "partner":"8gfc" + "partner":"8gfh" }, { "sim":53.0, - "partner":"8gfd" + "partner":"8gfi" }, { "sim":53.0, - "partner":"8gfe" + "partner":"8gfj" }, { "sim":53.0, - "partner":"8gff" + "partner":"8gfl" }, { "sim":53.0, - "partner":"8gfg" + "partner":"8gfm" }, { "sim":53.0, - "partner":"8gfh" + "partner":"8gez" }, { "sim":53.0, - "partner":"8gfi" + "partner":"8gf0" }, { "sim":53.0, - "partner":"8gfj" + "partner":"8gfp" }, { "sim":53.0, - "partner":"8gfl" + "partner":"8gf1" }, { "sim":53.0, - "partner":"8gfm" + "partner":"8gfq" }, { "sim":53.0, - "partner":"8gez" + "partner":"8gfs" }, { "sim":53.0, @@ -599440,10 +601970,6 @@ "sim":53.0, "partner":"7bn9" }, - { - "sim":53.0, - "partner":"6yt0" - }, { "sim":53.0, "partner":"4zhj" @@ -599460,6 +601986,10 @@ "sim":53.0, "partner":"6ytj" }, + { + "sim":53.0, + "partner":"6yt0" + }, { "sim":52.0, "partner":"1yww" @@ -599536,10 +602066,6 @@ "sim":52.0, "partner":"4qxz" }, - { - "sim":52.0, - "partner":"5c7p" - }, { "sim":52.0, "partner":"7f0y" @@ -599556,6 +602082,10 @@ "sim":52.0, "partner":"7f11" }, + { + "sim":52.0, + "partner":"5c7p" + }, { "sim":52.0, "partner":"7ckv" @@ -599694,11 +602224,11 @@ }, { "sim":52.0, - "partner":"4fq7" + "partner":"4fq5" }, { "sim":52.0, - "partner":"4fq5" + "partner":"4fq7" }, { "sim":52.0, @@ -599720,10 +602250,6 @@ "sim":52.0, "partner":"3u3j" }, - { - "sim":52.0, - "partner":"3u3r" - }, { "sim":52.0, "partner":"3u3k" @@ -599736,25 +602262,29 @@ "sim":52.0, "partner":"3u3o" }, + { + "sim":52.0, + "partner":"3u3r" + }, { "sim":52.0, "partner":"3utn" }, { "sim":52.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":52.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":52.0, - "partner":"3tm8" + "partner":"3tmc" }, { "sim":52.0, - "partner":"3tmb" + "partner":"3tmd" }, { "sim":52.0, @@ -599766,11 +602296,11 @@ }, { "sim":52.0, - "partner":"7js3" + "partner":"8g5w" }, { "sim":52.0, - "partner":"8g5w" + "partner":"7js3" }, { "sim":52.0, @@ -599786,7 +602316,7 @@ }, { "sim":52.0, - "partner":"6pi5" + "partner":"6pi6" }, { "sim":52.0, @@ -599794,7 +602324,7 @@ }, { "sim":52.0, - "partner":"6pi6" + "partner":"6pi5" }, { "sim":52.0, @@ -599856,10 +602386,6 @@ "sim":52.0, "partner":"4cqd" }, - { - "sim":52.0, - "partner":"5cu7" - }, { "sim":52.0, "partner":"4fdt" @@ -599874,15 +602400,19 @@ }, { "sim":52.0, - "partner":"6v99" + "partner":"5cu7" }, { "sim":52.0, - "partner":"6v9a" + "partner":"6v96" }, { "sim":52.0, - "partner":"6v96" + "partner":"6v99" + }, + { + "sim":52.0, + "partner":"6v9a" }, { "sim":52.0, @@ -599954,15 +602484,15 @@ }, { "sim":52.0, - "partner":"7an1" + "partner":"7oqd" }, { "sim":52.0, - "partner":"7oqd" + "partner":"2x50" }, { "sim":52.0, - "partner":"2x50" + "partner":"7an1" }, { "sim":52.0, @@ -599998,15 +602528,15 @@ }, { "sim":52.0, - "partner":"5kdn" + "partner":"5kds" }, { "sim":52.0, - "partner":"5kds" + "partner":"5kdu" }, { "sim":52.0, - "partner":"5kdu" + "partner":"5kdn" }, { "sim":52.0, @@ -600032,10 +602562,6 @@ "sim":52.0, "partner":"6dqx" }, - { - "sim":52.0, - "partner":"7tgl" - }, { "sim":52.0, "partner":"7tgm" @@ -600048,6 +602574,10 @@ "sim":52.0, "partner":"7tgk" }, + { + "sim":52.0, + "partner":"7tgl" + }, { "sim":52.0, "partner":"2o1u" @@ -600076,10 +602606,6 @@ "sim":52.0, "partner":"7ufu" }, - { - "sim":52.0, - "partner":"4xc6" - }, { "sim":52.0, "partner":"4xc7" @@ -600104,6 +602630,10 @@ "sim":52.0, "partner":"5cjw" }, + { + "sim":52.0, + "partner":"4xc6" + }, { "sim":52.0, "partner":"3va7" @@ -600138,11 +602668,11 @@ }, { "sim":51.0, - "partner":"5ho3" + "partner":"5ho1" }, { "sim":51.0, - "partner":"5ho1" + "partner":"5ho3" }, { "sim":51.0, @@ -600272,17 +602802,13 @@ "sim":51.0, "partner":"7ywg" }, - { - "sim":51.0, - "partner":"4kpc" - }, { "sim":51.0, "partner":"7f0z" }, { "sim":51.0, - "partner":"7xtl" + "partner":"4kpc" }, { "sim":51.0, @@ -600294,7 +602820,11 @@ }, { "sim":51.0, - "partner":"5edd" + "partner":"7xtl" + }, + { + "sim":51.0, + "partner":"8p8o" }, { "sim":51.0, @@ -600330,15 +602860,15 @@ }, { "sim":51.0, - "partner":"8p8o" + "partner":"1sm8" }, { "sim":51.0, - "partner":"1sm8" + "partner":"3hza" }, { "sim":51.0, - "partner":"3hza" + "partner":"5edd" }, { "sim":51.0, @@ -600384,14 +602914,6 @@ "sim":51.0, "partner":"7efx" }, - { - "sim":51.0, - "partner":"3jun" - }, - { - "sim":51.0, - "partner":"3juo" - }, { "sim":51.0, "partner":"3jup" @@ -600424,6 +602946,14 @@ "sim":51.0, "partner":"3jum" }, + { + "sim":51.0, + "partner":"3jun" + }, + { + "sim":51.0, + "partner":"3juo" + }, { "sim":51.0, "partner":"7l8k" @@ -600478,31 +603008,19 @@ }, { "sim":51.0, - "partner":"6vll" - }, - { - "sim":51.0, - "partner":"5wg9" - }, - { - "sim":51.0, - "partner":"6v53" - }, - { - "sim":51.0, - "partner":"8edz" + "partner":"5wap" }, { "sim":51.0, - "partner":"6wij" + "partner":"6v56" }, { "sim":51.0, - "partner":"8dvo" + "partner":"6whm" }, { "sim":51.0, - "partner":"5wap" + "partner":"7kop" }, { "sim":51.0, @@ -600510,23 +603028,15 @@ }, { "sim":51.0, - "partner":"6v56" - }, - { - "sim":51.0, - "partner":"6whm" - }, - { - "sim":51.0, - "partner":"7kop" + "partner":"6v9e" }, { "sim":51.0, - "partner":"5w7u" + "partner":"6vbr" }, { "sim":51.0, - "partner":"6v9e" + "partner":"6vg9" }, { "sim":51.0, @@ -600534,11 +603044,11 @@ }, { "sim":51.0, - "partner":"6vbr" + "partner":"8e21" }, { "sim":51.0, - "partner":"6vg9" + "partner":"5w7u" }, { "sim":51.0, @@ -600554,27 +603064,31 @@ }, { "sim":51.0, - "partner":"8e21" + "partner":"5wfw" }, { "sim":51.0, - "partner":"5wfw" + "partner":"8dqs" }, { "sim":51.0, "partner":"5deb" }, + { + "sim":51.0, + "partner":"7kbc" + }, { "sim":51.0, "partner":"5dbs" }, { "sim":51.0, - "partner":"7kbc" + "partner":"6v6x" }, { "sim":51.0, - "partner":"5w9g" + "partner":"6vjh" }, { "sim":51.0, @@ -600582,35 +603096,35 @@ }, { "sim":51.0, - "partner":"8dqs" + "partner":"8dpj" }, { "sim":51.0, - "partner":"5vqn" + "partner":"8dtw" }, { "sim":51.0, - "partner":"5wdw" + "partner":"5w9g" }, { "sim":51.0, - "partner":"5wfz" + "partner":"7kny" }, { "sim":51.0, - "partner":"6v6x" + "partner":"7lp8" }, { "sim":51.0, - "partner":"6vjh" + "partner":"5vqn" }, { "sim":51.0, - "partner":"7kny" + "partner":"5wdw" }, { "sim":51.0, - "partner":"7lp8" + "partner":"5wfz" }, { "sim":51.0, @@ -600618,15 +603132,15 @@ }, { "sim":51.0, - "partner":"8dpj" + "partner":"8e1q" }, { "sim":51.0, - "partner":"8dtw" + "partner":"7uuh" }, { "sim":51.0, - "partner":"7uuh" + "partner":"7lm4" }, { "sim":51.0, @@ -600642,15 +603156,11 @@ }, { "sim":51.0, - "partner":"7lm4" - }, - { - "sim":51.0, - "partner":"8e1q" + "partner":"6vl3" }, { "sim":51.0, - "partner":"5vpt" + "partner":"6w7a" }, { "sim":51.0, @@ -600658,11 +603168,11 @@ }, { "sim":51.0, - "partner":"6vl3" + "partner":"8e4s" }, { "sim":51.0, - "partner":"6w7a" + "partner":"5vpt" }, { "sim":51.0, @@ -600670,27 +603180,27 @@ }, { "sim":51.0, - "partner":"5vp8" + "partner":"7k87" }, { "sim":51.0, - "partner":"5w92" + "partner":"7n47" }, { "sim":51.0, - "partner":"5wa6" + "partner":"5vp8" }, { "sim":51.0, - "partner":"7k87" + "partner":"5w92" }, { "sim":51.0, - "partner":"7n47" + "partner":"5wa6" }, { "sim":51.0, - "partner":"8e4s" + "partner":"8dip" }, { "sim":51.0, @@ -600706,7 +603216,7 @@ }, { "sim":51.0, - "partner":"5vrj" + "partner":"6wj4" }, { "sim":51.0, @@ -600714,11 +603224,11 @@ }, { "sim":51.0, - "partner":"8dip" + "partner":"5vrj" }, { "sim":51.0, - "partner":"6wj4" + "partner":"6ws3" }, { "sim":51.0, @@ -600726,7 +603236,7 @@ }, { "sim":51.0, - "partner":"6ws3" + "partner":"6viv" }, { "sim":51.0, @@ -600734,19 +603244,15 @@ }, { "sim":51.0, - "partner":"5w73" - }, - { - "sim":51.0, - "partner":"6viv" + "partner":"7k77" }, { "sim":51.0, - "partner":"7k77" + "partner":"7umr" }, { "sim":51.0, - "partner":"7umr" + "partner":"5w73" }, { "sim":51.0, @@ -600772,6 +603278,10 @@ "sim":51.0, "partner":"4r1j" }, + { + "sim":51.0, + "partner":"6vll" + }, { "sim":51.0, "partner":"7k0w" @@ -600780,6 +603290,26 @@ "sim":51.0, "partner":"7n55" }, + { + "sim":51.0, + "partner":"8edz" + }, + { + "sim":51.0, + "partner":"6v53" + }, + { + "sim":51.0, + "partner":"8dvo" + }, + { + "sim":51.0, + "partner":"6wij" + }, + { + "sim":51.0, + "partner":"5wg9" + }, { "sim":51.0, "partner":"6ede" @@ -600880,14 +603410,6 @@ "sim":51.0, "partner":"2ym0" }, - { - "sim":51.0, - "partner":"3nh1" - }, - { - "sim":51.0, - "partner":"3v9z" - }, { "sim":51.0, "partner":"3v9u" @@ -600940,6 +603462,14 @@ "sim":51.0, "partner":"3v9s" }, + { + "sim":51.0, + "partner":"3nh1" + }, + { + "sim":51.0, + "partner":"3v9z" + }, { "sim":51.0, "partner":"3nt7" @@ -600958,11 +603488,11 @@ }, { "sim":51.0, - "partner":"2ium" + "partner":"7qej" }, { "sim":51.0, - "partner":"7qej" + "partner":"2ium" }, { "sim":51.0, @@ -600974,11 +603504,11 @@ }, { "sim":51.0, - "partner":"4cnf" + "partner":"7aie" }, { "sim":51.0, - "partner":"7aie" + "partner":"4cnf" }, { "sim":51.0, @@ -600988,25 +603518,17 @@ "sim":51.0, "partner":"5oj8" }, - { - "sim":51.0, - "partner":"6ey1" - }, { "sim":51.0, "partner":"6f0w" }, { "sim":51.0, - "partner":"7wzg" - }, - { - "sim":51.0, - "partner":"4ke6" + "partner":"6ey1" }, { "sim":51.0, - "partner":"4m7t" + "partner":"7wzg" }, { "sim":51.0, @@ -601040,6 +603562,14 @@ "sim":51.0, "partner":"3rli" }, + { + "sim":51.0, + "partner":"4ke6" + }, + { + "sim":51.0, + "partner":"4m7t" + }, { "sim":51.0, "partner":"1l2j" @@ -601070,15 +603600,15 @@ }, { "sim":51.0, - "partner":"1zw3" + "partner":"1zvz" }, { "sim":51.0, - "partner":"1zvz" + "partner":"1zw2" }, { "sim":51.0, - "partner":"1zw2" + "partner":"1zw3" }, { "sim":51.0, @@ -601126,23 +603656,23 @@ }, { "sim":51.0, - "partner":"5lto" + "partner":"5lt9" }, { "sim":51.0, - "partner":"4q2g" + "partner":"1zct" }, { "sim":51.0, - "partner":"5lt9" + "partner":"4q2e" }, { "sim":51.0, - "partner":"1zct" + "partner":"5lto" }, { "sim":51.0, - "partner":"4q2e" + "partner":"4q2g" }, { "sim":51.0, @@ -601238,11 +603768,11 @@ }, { "sim":51.0, - "partner":"5lsg" + "partner":"6t9c" }, { "sim":51.0, - "partner":"6t9c" + "partner":"5lsg" }, { "sim":51.0, @@ -601262,19 +603792,15 @@ }, { "sim":51.0, - "partner":"2oau" - }, - { - "sim":51.0, - "partner":"4hwa" + "partner":"6uzh" }, { "sim":51.0, - "partner":"6uzh" + "partner":"2oau" }, { "sim":51.0, - "partner":"3s3h" + "partner":"4hwa" }, { "sim":51.0, @@ -601288,6 +603814,10 @@ "sim":51.0, "partner":"3s3f" }, + { + "sim":51.0, + "partner":"3s3h" + }, { "sim":51.0, "partner":"2zni" @@ -601356,10 +603886,6 @@ "sim":51.0, "partner":"6k92" }, - { - "sim":51.0, - "partner":"3aio" - }, { "sim":51.0, "partner":"3aik" @@ -601378,15 +603904,11 @@ }, { "sim":51.0, - "partner":"4xrw" - }, - { - "sim":51.0, - "partner":"5exi" + "partner":"3aio" }, { "sim":51.0, - "partner":"5exj" + "partner":"4xrw" }, { "sim":51.0, @@ -601394,23 +603916,23 @@ }, { "sim":51.0, - "partner":"3h7u" + "partner":"5exi" }, { "sim":51.0, - "partner":"6asv" + "partner":"5exj" }, { "sim":51.0, - "partner":"7cgv" + "partner":"3h7u" }, { "sim":51.0, - "partner":"5tyq" + "partner":"6asv" }, { "sim":51.0, - "partner":"5u19" + "partner":"7cgv" }, { "sim":51.0, @@ -601430,31 +603952,31 @@ }, { "sim":51.0, - "partner":"7q4u" + "partner":"5tyq" }, { "sim":51.0, - "partner":"7q59" + "partner":"5u19" }, { "sim":51.0, - "partner":"7pp4" + "partner":"7zf2" }, { "sim":51.0, - "partner":"7zf2" + "partner":"7q4u" }, { "sim":51.0, - "partner":"5m8e" + "partner":"7q59" }, { "sim":51.0, - "partner":"4h2w" + "partner":"7pp4" }, { "sim":51.0, - "partner":"3mey" + "partner":"5m8e" }, { "sim":51.0, @@ -601512,6 +604034,14 @@ "sim":51.0, "partner":"4h2v" }, + { + "sim":51.0, + "partner":"4h2w" + }, + { + "sim":51.0, + "partner":"3mey" + }, { "sim":51.0, "partner":"2pvh" @@ -601574,67 +604104,67 @@ }, { "sim":51.0, - "partner":"4m25" + "partner":"4m26" }, { "sim":51.0, - "partner":"4m2i" + "partner":"4m27" }, { "sim":51.0, - "partner":"4ne0" + "partner":"6clw" }, { "sim":51.0, - "partner":"4m26" + "partner":"6clx" }, { "sim":51.0, - "partner":"4m27" + "partner":"4m2c" }, { "sim":51.0, - "partner":"6clw" + "partner":"6ems" }, { "sim":51.0, - "partner":"6clx" + "partner":"6xn0" }, { "sim":51.0, - "partner":"4m2c" + "partner":"4m2e" }, { "sim":51.0, - "partner":"4m2e" + "partner":"6xn1" }, { "sim":51.0, - "partner":"6ems" + "partner":"6xn2" }, { "sim":51.0, - "partner":"6xn0" + "partner":"4m2f" }, { "sim":51.0, - "partner":"6xn1" + "partner":"4m23" }, { "sim":51.0, - "partner":"4m2f" + "partner":"4m2g" }, { "sim":51.0, - "partner":"6xn2" + "partner":"4m25" }, { "sim":51.0, - "partner":"4m23" + "partner":"4m2i" }, { "sim":51.0, - "partner":"4m2g" + "partner":"4ne0" }, { "sim":51.0, @@ -601700,10 +604230,6 @@ "sim":51.0, "partner":"3a16" }, - { - "sim":51.0, - "partner":"2iua" - }, { "sim":51.0, "partner":"2iu8" @@ -601714,15 +604240,15 @@ }, { "sim":51.0, - "partner":"5hjn" + "partner":"2iua" }, { "sim":51.0, - "partner":"5hjq" + "partner":"5hjn" }, { "sim":51.0, - "partner":"3c1y" + "partner":"5hjq" }, { "sim":51.0, @@ -601774,19 +604300,11 @@ }, { "sim":51.0, - "partner":"2yjn" - }, - { - "sim":51.0, - "partner":"4ltz" - }, - { - "sim":51.0, - "partner":"7kj8" + "partner":"3c1y" }, { "sim":51.0, - "partner":"7kj9" + "partner":"2yjn" }, { "sim":51.0, @@ -601802,11 +604320,11 @@ }, { "sim":51.0, - "partner":"6axu" + "partner":"7kje" }, { "sim":51.0, - "partner":"7kje" + "partner":"6axu" }, { "sim":51.0, @@ -601862,11 +604380,19 @@ }, { "sim":51.0, - "partner":"4dn1" + "partner":"7kj8" }, { "sim":51.0, - "partner":"2gqn" + "partner":"4ltz" + }, + { + "sim":51.0, + "partner":"7kj9" + }, + { + "sim":51.0, + "partner":"4dn1" }, { "sim":51.0, @@ -601892,10 +604418,18 @@ "sim":51.0, "partner":"2fq6" }, + { + "sim":51.0, + "partner":"2gqn" + }, { "sim":51.0, "partner":"5xpj" }, + { + "sim":51.0, + "partner":"8s53" + }, { "sim":51.0, "partner":"6j82" @@ -601914,35 +604448,35 @@ }, { "sim":51.0, - "partner":"5dvi" + "partner":"4e2p" }, { "sim":51.0, - "partner":"5xw2" + "partner":"5dvj" }, { "sim":51.0, - "partner":"5dvj" + "partner":"3ssm" }, { "sim":51.0, - "partner":"4e2p" + "partner":"3ssn" }, { "sim":51.0, - "partner":"3ssm" + "partner":"3sso" }, { "sim":51.0, - "partner":"3ssn" + "partner":"5dvf" }, { "sim":51.0, - "partner":"3sso" + "partner":"5dvi" }, { "sim":51.0, - "partner":"5dvf" + "partner":"5xw2" }, { "sim":51.0, @@ -601966,11 +604500,11 @@ }, { "sim":51.0, - "partner":"4pk6" + "partner":"6r63" }, { "sim":51.0, - "partner":"6r63" + "partner":"4pk6" }, { "sim":51.0, @@ -601996,21 +604530,17 @@ "sim":51.0, "partner":"2gqd" }, - { - "sim":51.0, - "partner":"7cqq" - }, { "sim":51.0, "partner":"7cqu" }, { "sim":51.0, - "partner":"2o1t" + "partner":"7cqw" }, { "sim":51.0, - "partner":"7cqw" + "partner":"2o1t" }, { "sim":51.0, @@ -602024,6 +604554,10 @@ "sim":51.0, "partner":"7cqn" }, + { + "sim":51.0, + "partner":"7cqq" + }, { "sim":51.0, "partner":"2z67" @@ -602038,23 +604572,23 @@ }, { "sim":51.0, - "partner":"4gt2" + "partner":"4ach" }, { "sim":51.0, - "partner":"4acg" + "partner":"4acc" }, { "sim":51.0, - "partner":"4ach" + "partner":"4acd" }, { "sim":51.0, - "partner":"4acc" + "partner":"4gt2" }, { "sim":51.0, - "partner":"4acd" + "partner":"4acg" }, { "sim":51.0, @@ -602062,19 +604596,19 @@ }, { "sim":51.0, - "partner":"2gps" + "partner":"6jjo" }, { "sim":51.0, - "partner":"6jjo" + "partner":"2gpw" }, { "sim":51.0, - "partner":"6oi9" + "partner":"2gps" }, { "sim":51.0, - "partner":"2gpw" + "partner":"6oi9" }, { "sim":51.0, @@ -602082,15 +604616,15 @@ }, { "sim":51.0, - "partner":"4l2h" + "partner":"4epp" }, { "sim":51.0, - "partner":"4epp" + "partner":"4epq" }, { "sim":51.0, - "partner":"4epq" + "partner":"4l2h" }, { "sim":51.0, @@ -602178,15 +604712,15 @@ }, { "sim":51.0, - "partner":"6x0h" + "partner":"6x0j" }, { "sim":51.0, - "partner":"6x0j" + "partner":"6x0k" }, { "sim":51.0, - "partner":"6x0k" + "partner":"6x0h" }, { "sim":51.0, @@ -602272,10 +604806,6 @@ "sim":51.0, "partner":"6l4o" }, - { - "sim":51.0, - "partner":"5wm2" - }, { "sim":51.0, "partner":"5wm3" @@ -602298,19 +604828,19 @@ }, { "sim":51.0, - "partner":"7xsf" + "partner":"5wm2" }, { "sim":51.0, - "partner":"3rde" + "partner":"7xsf" }, { "sim":51.0, - "partner":"6j1f" + "partner":"3rde" }, { "sim":51.0, - "partner":"6j1e" + "partner":"6j1f" }, { "sim":51.0, @@ -602328,6 +604858,10 @@ "sim":51.0, "partner":"6j0p" }, + { + "sim":51.0, + "partner":"6j1e" + }, { "sim":51.0, "partner":"2wmi" @@ -602390,43 +604924,43 @@ }, { "sim":51.0, - "partner":"2yii" + "partner":"4c5u" }, { "sim":51.0, - "partner":"4c5s" + "partner":"4cq5" }, { "sim":51.0, - "partner":"4v2r" + "partner":"4baa" }, { "sim":51.0, - "partner":"4c5u" + "partner":"4c6g" }, { "sim":51.0, - "partner":"4cq5" + "partner":"4bab" }, { "sim":51.0, - "partner":"4baa" + "partner":"4c5r" }, { "sim":51.0, - "partner":"4c6g" + "partner":"2yii" }, { "sim":51.0, - "partner":"4bab" + "partner":"4v2q" }, { "sim":51.0, - "partner":"4c5r" + "partner":"4c5s" }, { "sim":51.0, - "partner":"4v2q" + "partner":"4v2r" }, { "sim":51.0, @@ -602448,10 +604982,6 @@ "sim":51.0, "partner":"5jrl" }, - { - "sim":51.0, - "partner":"7wlg" - }, { "sim":51.0, "partner":"7wj9" @@ -602480,6 +605010,10 @@ "sim":51.0, "partner":"7wjf" }, + { + "sim":51.0, + "partner":"7wlg" + }, { "sim":51.0, "partner":"5ayk" @@ -602514,15 +605048,15 @@ }, { "sim":51.0, - "partner":"7o3m" + "partner":"7o3n" }, { "sim":51.0, - "partner":"7o3n" + "partner":"7o3l" }, { "sim":51.0, - "partner":"7o3l" + "partner":"7o3m" }, { "sim":51.0, @@ -602546,11 +605080,11 @@ }, { "sim":50.0, - "partner":"6iva" + "partner":"6iww" }, { "sim":50.0, - "partner":"6iww" + "partner":"6iva" }, { "sim":50.0, @@ -602598,11 +605132,11 @@ }, { "sim":50.0, - "partner":"2jop" + "partner":"1nyn" }, { "sim":50.0, - "partner":"1nyn" + "partner":"2jop" }, { "sim":50.0, @@ -602654,15 +605188,15 @@ }, { "sim":50.0, - "partner":"4ozj" + "partner":"4ozn" }, { "sim":50.0, - "partner":"4ozl" + "partner":"4ozj" }, { "sim":50.0, - "partner":"4ozn" + "partner":"4ozl" }, { "sim":50.0, @@ -602692,10 +605226,6 @@ "sim":50.0, "partner":"2bze" }, - { - "sim":50.0, - "partner":"5wqi" - }, { "sim":50.0, "partner":"6ecy" @@ -602728,6 +605258,10 @@ "sim":50.0, "partner":"4lfm" }, + { + "sim":50.0, + "partner":"5wqi" + }, { "sim":50.0, "partner":"4lfn" @@ -602844,10 +605378,6 @@ "sim":50.0, "partner":"5b4n" }, - { - "sim":50.0, - "partner":"3th5" - }, { "sim":50.0, "partner":"4gzl" @@ -602870,15 +605400,11 @@ }, { "sim":50.0, - "partner":"3p6b" - }, - { - "sim":50.0, - "partner":"3l1u" + "partner":"3th5" }, { "sim":50.0, - "partner":"6pj9" + "partner":"3p6b" }, { "sim":50.0, @@ -602886,11 +605412,11 @@ }, { "sim":50.0, - "partner":"6pja" + "partner":"6pjp" }, { "sim":50.0, - "partner":"6pjp" + "partner":"6pjq" }, { "sim":50.0, @@ -602898,11 +605424,11 @@ }, { "sim":50.0, - "partner":"6pjq" + "partner":"6pjr" }, { "sim":50.0, - "partner":"6pjr" + "partner":"6pju" }, { "sim":50.0, @@ -602916,10 +605442,6 @@ "sim":50.0, "partner":"2gmw" }, - { - "sim":50.0, - "partner":"6pju" - }, { "sim":50.0, "partner":"4njp" @@ -602950,15 +605472,19 @@ }, { "sim":50.0, - "partner":"5f5j" + "partner":"6pj5" }, { "sim":50.0, - "partner":"6pj5" + "partner":"6pj7" }, { "sim":50.0, - "partner":"6pj7" + "partner":"5f5j" + }, + { + "sim":50.0, + "partner":"6pj8" }, { "sim":50.0, @@ -602966,7 +605492,15 @@ }, { "sim":50.0, - "partner":"6pj8" + "partner":"6pj9" + }, + { + "sim":50.0, + "partner":"3l1u" + }, + { + "sim":50.0, + "partner":"6pja" }, { "sim":50.0, @@ -602986,7 +605520,7 @@ }, { "sim":50.0, - "partner":"7fe0" + "partner":"7fe5" }, { "sim":50.0, @@ -602994,16 +605528,12 @@ }, { "sim":50.0, - "partner":"7fe5" + "partner":"7fe0" }, { "sim":50.0, "partner":"3eik" }, - { - "sim":50.0, - "partner":"6a98" - }, { "sim":50.0, "partner":"6a99" @@ -603016,6 +605546,10 @@ "sim":50.0, "partner":"6a9f" }, + { + "sim":50.0, + "partner":"6a98" + }, { "sim":50.0, "partner":"2xdu" @@ -603068,14 +605602,6 @@ "sim":50.0, "partner":"5ejl" }, - { - "sim":50.0, - "partner":"3ft5" - }, - { - "sim":50.0, - "partner":"2xdx" - }, { "sim":50.0, "partner":"3ft8" @@ -603144,6 +605670,14 @@ "sim":50.0, "partner":"2xhx" }, + { + "sim":50.0, + "partner":"3ft5" + }, + { + "sim":50.0, + "partner":"2xdx" + }, { "sim":50.0, "partner":"2ho1" @@ -603216,14 +605750,6 @@ "sim":50.0, "partner":"5c12" }, - { - "sim":50.0, - "partner":"6hxo" - }, - { - "sim":50.0, - "partner":"3dbp" - }, { "sim":50.0, "partner":"3mo7" @@ -603246,27 +605772,27 @@ }, { "sim":50.0, - "partner":"5vrc" + "partner":"6hxo" }, { "sim":50.0, - "partner":"6akv" + "partner":"3dbp" }, { "sim":50.0, - "partner":"6l8u" + "partner":"5vrc" }, { "sim":50.0, - "partner":"6wyi" + "partner":"6akv" }, { "sim":50.0, - "partner":"3quo" + "partner":"6l8u" }, { "sim":50.0, - "partner":"3qvf" + "partner":"6wyi" }, { "sim":50.0, @@ -603288,6 +605814,14 @@ "sim":50.0, "partner":"3qun" }, + { + "sim":50.0, + "partner":"3quo" + }, + { + "sim":50.0, + "partner":"3qvf" + }, { "sim":50.0, "partner":"3jyy" @@ -603318,11 +605852,11 @@ }, { "sim":50.0, - "partner":"4rdh" + "partner":"4rdi" }, { "sim":50.0, - "partner":"4rdi" + "partner":"4rdh" }, { "sim":50.0, @@ -603372,10 +605906,6 @@ "sim":50.0, "partner":"8r2x" }, - { - "sim":50.0, - "partner":"4pgc" - }, { "sim":50.0, "partner":"4pgd" @@ -603394,7 +605924,7 @@ }, { "sim":50.0, - "partner":"5uto" + "partner":"4pgc" }, { "sim":50.0, @@ -603402,12 +605932,16 @@ }, { "sim":50.0, - "partner":"6y5x" + "partner":"5uto" }, { "sim":50.0, "partner":"6y5y" }, + { + "sim":50.0, + "partner":"6y5x" + }, { "sim":50.0, "partner":"6cl4" @@ -603486,51 +606020,51 @@ }, { "sim":50.0, - "partner":"6cwo" + "partner":"3pdc" }, { "sim":50.0, - "partner":"3pdc" + "partner":"6cwo" }, { "sim":50.0, - "partner":"3sie" + "partner":"4i9z" }, { "sim":50.0, - "partner":"4g2w" + "partner":"4ia0" }, { "sim":50.0, - "partner":"4g2y" + "partner":"4oew" }, { "sim":50.0, - "partner":"4i9z" + "partner":"4oex" }, { "sim":50.0, - "partner":"4ia0" + "partner":"6iwi" }, { "sim":50.0, - "partner":"4oew" + "partner":"3shy" }, { "sim":50.0, - "partner":"4oex" + "partner":"3shz" }, { "sim":50.0, - "partner":"6iwi" + "partner":"3sie" }, { "sim":50.0, - "partner":"3shy" + "partner":"4g2w" }, { "sim":50.0, - "partner":"3shz" + "partner":"4g2y" }, { "sim":50.0, @@ -603628,10 +606162,6 @@ "sim":50.0, "partner":"5zyb" }, - { - "sim":50.0, - "partner":"7azd" - }, { "sim":50.0, "partner":"7az5" @@ -603662,23 +606192,27 @@ }, { "sim":50.0, - "partner":"5x06" + "partner":"7azg" }, { "sim":50.0, - "partner":"7azg" + "partner":"5x06" }, { "sim":50.0, "partner":"7azc" }, + { + "sim":50.0, + "partner":"7azd" + }, { "sim":50.0, "partner":"4xau" }, { "sim":50.0, - "partner":"6kjh" + "partner":"6y9d" }, { "sim":50.0, @@ -603686,39 +606220,39 @@ }, { "sim":50.0, - "partner":"6y8j" + "partner":"6kjp" }, { "sim":50.0, - "partner":"6y9c" + "partner":"6kjq" }, { "sim":50.0, - "partner":"6y9d" + "partner":"6kjr" }, { "sim":50.0, - "partner":"6kjj" + "partner":"6kjt" }, { "sim":50.0, - "partner":"6kjp" + "partner":"6y8s" }, { "sim":50.0, - "partner":"6kjq" + "partner":"6kjh" }, { "sim":50.0, - "partner":"6kjr" + "partner":"6y8j" }, { "sim":50.0, - "partner":"6kjt" + "partner":"6y9c" }, { "sim":50.0, - "partner":"6y8s" + "partner":"6kjj" }, { "sim":50.0, @@ -603734,15 +606268,15 @@ }, { "sim":50.0, - "partner":"6s0g" + "partner":"7bn6" }, { "sim":50.0, - "partner":"7bn6" + "partner":"6s23" }, { "sim":50.0, - "partner":"6s23" + "partner":"6s0g" }, { "sim":50.0, @@ -603780,18 +606314,6 @@ "sim":50.0, "partner":"4eay" }, - { - "sim":50.0, - "partner":"2y46" - }, - { - "sim":50.0, - "partner":"2y5n" - }, - { - "sim":50.0, - "partner":"2yca" - }, { "sim":50.0, "partner":"3zsn" @@ -603814,11 +606336,15 @@ }, { "sim":50.0, - "partner":"4r33" + "partner":"2y46" }, { "sim":50.0, - "partner":"6e9b" + "partner":"2y5n" + }, + { + "sim":50.0, + "partner":"2yca" }, { "sim":50.0, @@ -603836,6 +606362,14 @@ "sim":50.0, "partner":"4u7w" }, + { + "sim":50.0, + "partner":"6e9b" + }, + { + "sim":50.0, + "partner":"4r33" + }, { "sim":50.0, "partner":"3zu2" @@ -603942,7 +606476,7 @@ }, { "sim":50.0, - "partner":"4p8h" + "partner":"4ff6" }, { "sim":50.0, @@ -603950,79 +606484,79 @@ }, { "sim":50.0, - "partner":"5hjx" + "partner":"5hjy" }, { "sim":50.0, - "partner":"5koz" + "partner":"5han" }, { "sim":50.0, - "partner":"6hez" + "partner":"4feh" }, { "sim":50.0, - "partner":"5hjy" + "partner":"6hf3" }, { "sim":50.0, - "partner":"4ff6" + "partner":"4fdn" }, { "sim":50.0, - "partner":"6hf0" + "partner":"4fdo" }, { "sim":50.0, - "partner":"5han" + "partner":"4fdp" }, { "sim":50.0, - "partner":"4feh" + "partner":"5hao" }, { "sim":50.0, - "partner":"4fdn" + "partner":"6g83" }, { "sim":50.0, - "partner":"6hf3" + "partner":"4lf1" }, { "sim":50.0, - "partner":"4fdo" + "partner":"3oqc" }, { "sim":50.0, - "partner":"4fdp" + "partner":"5koz" }, { "sim":50.0, - "partner":"5hao" + "partner":"4lf2" }, { "sim":50.0, - "partner":"4lf1" + "partner":"5hk4" }, { "sim":50.0, - "partner":"6g83" + "partner":"4ncr" }, { "sim":50.0, - "partner":"3oqc" + "partner":"5hjx" }, { "sim":50.0, - "partner":"4lf2" + "partner":"6hez" }, { "sim":50.0, - "partner":"5hk4" + "partner":"4p8h" }, { "sim":50.0, - "partner":"4ncr" + "partner":"6hf0" }, { "sim":50.0, @@ -604078,23 +606612,23 @@ }, { "sim":50.0, - "partner":"2cj9" + "partner":"2cja" }, { "sim":50.0, - "partner":"5o3m" + "partner":"2cim" }, { "sim":50.0, - "partner":"2cja" + "partner":"2cjb" }, { "sim":50.0, - "partner":"2cim" + "partner":"5o3m" }, { "sim":50.0, - "partner":"2cjb" + "partner":"2cj9" }, { "sim":50.0, @@ -604164,10 +606698,6 @@ "sim":50.0, "partner":"2ix1" }, - { - "sim":50.0, - "partner":"2bpo" - }, { "sim":50.0, "partner":"2bf4" @@ -604178,11 +606708,11 @@ }, { "sim":50.0, - "partner":"8god" + "partner":"2bpo" }, { "sim":50.0, - "partner":"6k8s" + "partner":"8god" }, { "sim":50.0, @@ -604192,6 +606722,10 @@ "sim":50.0, "partner":"6k8u" }, + { + "sim":50.0, + "partner":"6k8s" + }, { "sim":50.0, "partner":"5y9d" @@ -604230,15 +606764,15 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"6edz" }, { "sim":50.0, - "partner":"6edz" + "partner":"6ee1" }, { "sim":50.0, - "partner":"6ee1" + "partner":"6edw" }, { "sim":50.0, @@ -604326,86 +606860,86 @@ ], "subtitle":"Crystal structure of an 8-repeat consensus tpr superhelix with gadolinium", "tags":[ - "metal coordination", - "ctpr", + "polymorphism", "de novo protein", - "polymorphism" + "metal coordination", + "ctpr" ], "keywords":[ - "facile", + "form", + "crystalline", + "engineering", + "calculations", + "pofs", + "allow", + "controlled", + "responsible", + "presents", + "metal", + "negatively", + "opening", + "exposed", + "thermodynamically", + "repeat", "diverse", - "scope", - "obtained", - "density", - "despite", + "comparison", + "structurally", + "requirements", "salts", - "amino", - "proteins", + "single", + "porosity", "functional", - "frameworks", + "kinetically", + "polymorphic", "thus", - "coordination", - "presents", - "assemblies", - "pofs", - "strategy", - "single", - "stable", - "metal", - "cluster", - "calculations", - "opening", - "scaffolds", + "application", + "residues", + "preferences", + "controllable", "acid", - "negatively", - "polymorphs", - "trapped", + "scaffolds", + "addition", "finding", - "controlled", - "polymorphic", - "allow", - "residues", - "abundance", - "tetratricopeptide", + "diversity", + "strategy", + "new", + "frameworks", + "ion", + "protein", + "trapped", + "polymorphism", + "amino", "exploiting", - "direct", - "crystal", - "engineering", - "geometric", + "proteins", + "tetratricopeptide", + "achieved", + "cluster", + "polymorphs", "innate", - "kinetically", - "application", - "addition", - "polymorphism", - "increasingly", - "comparison", - "protein", - "controllable", - "biocompatible", - "applications", - "states", - "requirements", - "negative", - "charged", - "theory", - "structurally", - "responsible", - "repeat", "showed", - "diversity", - "thermodynamically", - "minimal", "varying", - "crystalline", - "form", - "porosity", - "achieved", - "preferences", - "exposed", + "direct", "consensus", + "coordination", + "charged", + "biocompatible", + "negative", + "states", + "scope", "crystals", - "ion", - "new" + "increasingly", + "density", + "despite", + "applications", + "crystal", + "stable", + "theory", + "assemblies", + "minimal", + "abundance", + "obtained", + "geometric", + "facile" ], "release_date":"2024-02-21", "publication":"\"Diverse crystalline protein scaffolds through metal-dependent polymorphism\", Protein Sci., 33, e4971-e4971", @@ -604438,11 +606972,11 @@ "seq_thr_sim_designed":[ { "sim":304.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":304.0, - "partner":"8cqq" + "partner":"8cqp" }, { "sim":304.0, @@ -604450,27 +606984,27 @@ }, { "sim":304.0, - "partner":"8chy" + "partner":"8cmq" }, { "sim":304.0, - "partner":"8cmq" + "partner":"8bu0" }, { "sim":304.0, - "partner":"8ckr" + "partner":"8cp8" }, { "sim":304.0, - "partner":"8cig" + "partner":"8cqq" }, { "sim":304.0, - "partner":"8cqp" + "partner":"8chy" }, { "sim":304.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":218.0, @@ -604506,11 +607040,11 @@ }, { "sim":132.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":132.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":124.0, @@ -604522,15 +607056,15 @@ }, { "sim":94.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":94.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":94.0, - "partner":"8cus" + "partner":"8cwz" }, { "sim":93.0, @@ -604578,10 +607112,6 @@ "sim":102.0, "partner":"7y4i" }, - { - "sim":102.0, - "partner":"8dtf" - }, { "sim":102.0, "partner":"8dtg" @@ -604595,8 +607125,8 @@ "partner":"8dti" }, { - "sim":98.0, - "partner":"4rg6" + "sim":102.0, + "partner":"8dtf" }, { "sim":98.0, @@ -604608,15 +607138,11 @@ }, { "sim":98.0, - "partner":"6tka" - }, - { - "sim":98.0, - "partner":"5lcw" + "partner":"4rg6" }, { "sim":98.0, - "partner":"6q6g" + "partner":"6tka" }, { "sim":98.0, @@ -604640,16 +607166,12 @@ }, { "sim":98.0, - "partner":"8pkp" + "partner":"6tlj" }, { "sim":98.0, "partner":"5l9u" }, - { - "sim":98.0, - "partner":"6tlj" - }, { "sim":98.0, "partner":"6q6h" @@ -604662,6 +607184,10 @@ "sim":98.0, "partner":"5a31" }, + { + "sim":98.0, + "partner":"8pkp" + }, { "sim":98.0, "partner":"5g05" @@ -604676,23 +607202,15 @@ }, { "sim":98.0, - "partner":"8tau" - }, - { - "sim":97.0, - "partner":"4xif" - }, - { - "sim":97.0, - "partner":"8fe7" + "partner":"6q6g" }, { - "sim":97.0, - "partner":"4gyw" + "sim":98.0, + "partner":"8tau" }, { - "sim":97.0, - "partner":"5vif" + "sim":98.0, + "partner":"5lcw" }, { "sim":97.0, @@ -604734,6 +607252,10 @@ "sim":97.0, "partner":"5c1d" }, + { + "sim":97.0, + "partner":"6ma1" + }, { "sim":97.0, "partner":"3pe4" @@ -604756,15 +607278,15 @@ }, { "sim":97.0, - "partner":"6ma1" + "partner":"6ma2" }, { "sim":97.0, - "partner":"4n3c" + "partner":"8fe6" }, { "sim":97.0, - "partner":"6ma2" + "partner":"4n3c" }, { "sim":97.0, @@ -604772,7 +607294,7 @@ }, { "sim":97.0, - "partner":"8fe6" + "partner":"8fuf" }, { "sim":97.0, @@ -604784,7 +607306,11 @@ }, { "sim":97.0, - "partner":"8fuf" + "partner":"8cm9" + }, + { + "sim":97.0, + "partner":"6ma5" }, { "sim":97.0, @@ -604792,11 +607318,15 @@ }, { "sim":97.0, - "partner":"8cm9" + "partner":"8fe7" }, { "sim":97.0, - "partner":"6ma5" + "partner":"6ibo" + }, + { + "sim":97.0, + "partner":"6q4m" }, { "sim":97.0, @@ -604804,11 +607334,15 @@ }, { "sim":97.0, - "partner":"6ibo" + "partner":"4xif" }, { "sim":97.0, - "partner":"6q4m" + "partner":"4gyw" + }, + { + "sim":97.0, + "partner":"5vif" }, { "sim":96.0, @@ -604876,11 +607410,11 @@ }, { "sim":93.0, - "partner":"7ep7" + "partner":"4g2v" }, { "sim":93.0, - "partner":"4g2v" + "partner":"7ep7" }, { "sim":93.0, @@ -604892,15 +607426,15 @@ }, { "sim":90.0, - "partner":"8a5y" + "partner":"8a3t" }, { "sim":90.0, - "partner":"8a3t" + "partner":"8a61" }, { "sim":90.0, - "partner":"8a61" + "partner":"8a5y" }, { "sim":85.0, @@ -604924,19 +607458,19 @@ }, { "sim":75.0, - "partner":"6voa" + "partner":"6vbu" }, { "sim":75.0, - "partner":"6vnw" + "partner":"6vbv" }, { "sim":75.0, - "partner":"6vbu" + "partner":"6voa" }, { "sim":75.0, - "partner":"6vbv" + "partner":"6vnw" }, { "sim":72.0, @@ -604970,10 +607504,6 @@ "sim":70.0, "partner":"2c0m" }, - { - "sim":70.0, - "partner":"4kyo" - }, { "sim":70.0, "partner":"3r9a" @@ -604986,6 +607516,10 @@ "sim":70.0, "partner":"4kxk" }, + { + "sim":70.0, + "partner":"4kyo" + }, { "sim":70.0, "partner":"1fch" @@ -605368,11 +607902,11 @@ }, { "sim":51.0, - "partner":"4i9e" + "partner":"3ulq" }, { "sim":51.0, - "partner":"3ulq" + "partner":"4i9e" }, { "sim":51.0, @@ -605388,11 +607922,11 @@ }, { "sim":50.0, - "partner":"6fdp" + "partner":"6fdt" }, { "sim":50.0, - "partner":"6fdt" + "partner":"6fdp" }, { "sim":50.0, @@ -605400,11 +607934,11 @@ }, { "sim":50.0, - "partner":"7qws" + "partner":"6t59" }, { "sim":50.0, - "partner":"6t59" + "partner":"7qws" }, { "sim":50.0, @@ -605462,7 +607996,7 @@ ], "seq_max_sim_designed":{ "sim":304.0, - "partner":"8bu0" + "partner":"8ckr" }, "seq_max_sim_natural":{ "sim":216.0, @@ -605520,86 +608054,86 @@ ], "subtitle":"Crystal structure of an 8-repeat consensus tpr superhelix with zinc", "tags":[ - "metal coordination", - "ctpr", + "polymorphism", "de novo protein", - "polymorphism" + "metal coordination", + "ctpr" ], "keywords":[ - "facile", + "form", + "crystalline", + "engineering", + "calculations", + "pofs", + "allow", + "controlled", + "responsible", + "presents", + "metal", + "negatively", + "opening", + "exposed", + "thermodynamically", + "repeat", "diverse", - "scope", - "obtained", - "density", - "despite", + "comparison", + "structurally", + "requirements", "salts", - "amino", - "proteins", + "single", + "porosity", "functional", - "frameworks", + "kinetically", + "polymorphic", "thus", - "coordination", - "presents", - "assemblies", - "pofs", - "strategy", - "single", - "stable", - "metal", - "cluster", - "calculations", - "opening", - "scaffolds", + "application", + "residues", + "preferences", + "controllable", "acid", - "negatively", - "polymorphs", - "trapped", + "scaffolds", + "addition", "finding", - "controlled", - "polymorphic", - "allow", - "residues", - "abundance", - "tetratricopeptide", + "diversity", + "strategy", + "new", + "frameworks", + "ion", + "protein", + "trapped", + "polymorphism", + "amino", "exploiting", - "direct", - "crystal", - "engineering", - "geometric", + "proteins", + "tetratricopeptide", + "achieved", + "cluster", + "polymorphs", "innate", - "kinetically", - "application", - "addition", - "polymorphism", - "increasingly", - "comparison", - "protein", - "controllable", - "biocompatible", - "applications", - "states", - "requirements", - "negative", - "charged", - "theory", - "structurally", - "responsible", - "repeat", "showed", - "diversity", - "thermodynamically", - "minimal", "varying", - "crystalline", - "form", - "porosity", - "achieved", - "preferences", - "exposed", + "direct", "consensus", + "coordination", + "charged", + "biocompatible", + "negative", + "states", + "scope", "crystals", - "ion", - "new" + "increasingly", + "density", + "despite", + "applications", + "crystal", + "stable", + "theory", + "assemblies", + "minimal", + "abundance", + "obtained", + "geometric", + "facile" ], "release_date":"2024-02-21", "publication":"\"Diverse crystalline protein scaffolds through metal-dependent polymorphism\", Protein Sci., 33, e4971-e4971", @@ -605632,11 +608166,11 @@ "seq_thr_sim_designed":[ { "sim":622.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":622.0, - "partner":"8cqq" + "partner":"8cqp" }, { "sim":622.0, @@ -605648,19 +608182,19 @@ }, { "sim":622.0, - "partner":"8ckr" + "partner":"8bu0" }, { "sim":622.0, - "partner":"8cig" + "partner":"8cp8" }, { "sim":622.0, - "partner":"8cqp" + "partner":"8cqq" }, { "sim":622.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":303.0, @@ -605700,11 +608234,11 @@ }, { "sim":136.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":136.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":127.0, @@ -605720,15 +608254,15 @@ }, { "sim":94.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":94.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":94.0, - "partner":"8cus" + "partner":"8cwz" } ], "seq_thr_sim_natural":[ @@ -605760,10 +608294,6 @@ "sim":178.0, "partner":"7y4i" }, - { - "sim":178.0, - "partner":"8dtf" - }, { "sim":178.0, "partner":"8dtg" @@ -605776,6 +608306,10 @@ "sim":178.0, "partner":"8dti" }, + { + "sim":178.0, + "partner":"8dtf" + }, { "sim":164.0, "partner":"8ur5" @@ -605822,23 +608356,23 @@ }, { "sim":139.0, - "partner":"7ep7" + "partner":"4g2v" }, { "sim":139.0, - "partner":"4g2v" + "partner":"7ep7" }, { "sim":138.0, - "partner":"8a5y" + "partner":"8a3t" }, { "sim":138.0, - "partner":"8a3t" + "partner":"8a61" }, { "sim":138.0, - "partner":"8a61" + "partner":"8a5y" }, { "sim":136.0, @@ -605852,10 +608386,6 @@ "sim":131.0, "partner":"6xt9" }, - { - "sim":130.0, - "partner":"4rg6" - }, { "sim":130.0, "partner":"4rg7" @@ -605866,11 +608396,7 @@ }, { "sim":130.0, - "partner":"5lcw" - }, - { - "sim":130.0, - "partner":"6q6g" + "partner":"4rg6" }, { "sim":130.0, @@ -605894,16 +608420,12 @@ }, { "sim":130.0, - "partner":"8pkp" + "partner":"6tlj" }, { "sim":130.0, "partner":"5l9u" }, - { - "sim":130.0, - "partner":"6tlj" - }, { "sim":130.0, "partner":"6q6h" @@ -605916,6 +608438,10 @@ "sim":130.0, "partner":"5a31" }, + { + "sim":130.0, + "partner":"8pkp" + }, { "sim":130.0, "partner":"5g05" @@ -605928,25 +608454,33 @@ "sim":130.0, "partner":"4ui9" }, + { + "sim":130.0, + "partner":"6q6g" + }, { "sim":130.0, "partner":"8tau" }, + { + "sim":130.0, + "partner":"5lcw" + }, { "sim":125.0, - "partner":"6voa" + "partner":"6vbu" }, { "sim":125.0, - "partner":"6vnw" + "partner":"6vbv" }, { "sim":125.0, - "partner":"6vbu" + "partner":"6voa" }, { "sim":125.0, - "partner":"6vbv" + "partner":"6vnw" }, { "sim":122.0, @@ -605972,22 +608506,6 @@ "sim":107.0, "partner":"6tka" }, - { - "sim":106.0, - "partner":"4xif" - }, - { - "sim":106.0, - "partner":"8fe7" - }, - { - "sim":106.0, - "partner":"4gyw" - }, - { - "sim":106.0, - "partner":"5vif" - }, { "sim":106.0, "partner":"4xi9" @@ -606028,6 +608546,10 @@ "sim":106.0, "partner":"5c1d" }, + { + "sim":106.0, + "partner":"6ma1" + }, { "sim":106.0, "partner":"3pe4" @@ -606050,15 +608572,15 @@ }, { "sim":106.0, - "partner":"6ma1" + "partner":"6ma2" }, { "sim":106.0, - "partner":"4n3c" + "partner":"8fe6" }, { "sim":106.0, - "partner":"6ma2" + "partner":"4n3c" }, { "sim":106.0, @@ -606066,7 +608588,7 @@ }, { "sim":106.0, - "partner":"8fe6" + "partner":"8fuf" }, { "sim":106.0, @@ -606078,7 +608600,11 @@ }, { "sim":106.0, - "partner":"8fuf" + "partner":"8cm9" + }, + { + "sim":106.0, + "partner":"6ma5" }, { "sim":106.0, @@ -606086,11 +608612,15 @@ }, { "sim":106.0, - "partner":"8cm9" + "partner":"8fe7" }, { "sim":106.0, - "partner":"6ma5" + "partner":"6ibo" + }, + { + "sim":106.0, + "partner":"6q4m" }, { "sim":106.0, @@ -606098,11 +608628,15 @@ }, { "sim":106.0, - "partner":"6ibo" + "partner":"4xif" }, { "sim":106.0, - "partner":"6q4m" + "partner":"4gyw" + }, + { + "sim":106.0, + "partner":"5vif" }, { "sim":105.0, @@ -606160,10 +608694,6 @@ "sim":87.0, "partner":"2c0m" }, - { - "sim":87.0, - "partner":"4kyo" - }, { "sim":87.0, "partner":"3r9a" @@ -606176,6 +608706,10 @@ "sim":87.0, "partner":"4kxk" }, + { + "sim":87.0, + "partner":"4kyo" + }, { "sim":87.0, "partner":"1fch" @@ -606382,11 +608916,11 @@ }, { "sim":70.0, - "partner":"5w5i" + "partner":"5w5h" }, { "sim":70.0, - "partner":"5w5h" + "partner":"5w5i" }, { "sim":69.0, @@ -606446,11 +608980,11 @@ }, { "sim":59.0, - "partner":"7qws" + "partner":"6t59" }, { "sim":59.0, - "partner":"6t59" + "partner":"7qws" }, { "sim":59.0, @@ -606506,11 +609040,11 @@ }, { "sim":58.0, - "partner":"4i9e" + "partner":"3ulq" }, { "sim":58.0, - "partner":"3ulq" + "partner":"4i9e" }, { "sim":57.0, @@ -606626,11 +609160,11 @@ }, { "sim":55.0, - "partner":"8hmc" + "partner":"8hmd" }, { "sim":55.0, - "partner":"8hmd" + "partner":"8hmc" }, { "sim":54.0, @@ -606690,11 +609224,11 @@ }, { "sim":52.0, - "partner":"6fdp" + "partner":"6fdt" }, { "sim":52.0, - "partner":"6fdt" + "partner":"6fdp" }, { "sim":52.0, @@ -606740,7 +609274,7 @@ ], "seq_max_sim_designed":{ "sim":622.0, - "partner":"8bu0" + "partner":"8ckr" }, "seq_max_sim_natural":{ "sim":233.0, @@ -606798,86 +609332,86 @@ ], "subtitle":"Crystal structure of an 8-repeat consensus tpr superhelix in tris buffer with calcium", "tags":[ - "metal coordination", - "ctpr", + "polymorphism", "de novo protein", - "polymorphism" + "metal coordination", + "ctpr" ], "keywords":[ - "facile", + "form", + "crystalline", + "engineering", + "calculations", + "pofs", + "allow", + "controlled", + "responsible", + "presents", + "metal", + "negatively", + "opening", + "exposed", + "thermodynamically", + "repeat", "diverse", - "scope", - "obtained", - "density", - "despite", + "comparison", + "structurally", + "requirements", "salts", - "amino", - "proteins", + "single", + "porosity", "functional", - "frameworks", + "kinetically", + "polymorphic", "thus", - "coordination", - "presents", - "assemblies", - "pofs", - "strategy", - "single", - "stable", - "metal", - "cluster", - "calculations", - "opening", - "scaffolds", + "application", + "residues", + "preferences", + "controllable", "acid", - "negatively", - "polymorphs", - "trapped", + "scaffolds", + "addition", "finding", - "controlled", - "polymorphic", - "allow", - "residues", - "abundance", - "tetratricopeptide", + "diversity", + "strategy", + "new", + "frameworks", + "ion", + "protein", + "trapped", + "polymorphism", + "amino", "exploiting", - "direct", - "crystal", - "engineering", - "geometric", + "proteins", + "tetratricopeptide", + "achieved", + "cluster", + "polymorphs", "innate", - "kinetically", - "application", - "addition", - "polymorphism", - "increasingly", - "comparison", - "protein", - "controllable", - "biocompatible", - "applications", - "states", - "requirements", - "negative", - "charged", - "theory", - "structurally", - "responsible", - "repeat", "showed", - "diversity", - "thermodynamically", - "minimal", "varying", - "crystalline", - "form", - "porosity", - "achieved", - "preferences", - "exposed", + "direct", "consensus", + "coordination", + "charged", + "biocompatible", + "negative", + "states", + "scope", "crystals", - "ion", - "new" + "increasingly", + "density", + "despite", + "applications", + "crystal", + "stable", + "theory", + "assemblies", + "minimal", + "abundance", + "obtained", + "geometric", + "facile" ], "release_date":"2024-02-21", "publication":"\"Diverse crystalline protein scaffolds through metal-dependent polymorphism\", Protein Sci., 33, e4971-e4971", @@ -606910,11 +609444,11 @@ "seq_thr_sim_designed":[ { "sim":622.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":622.0, - "partner":"8cqq" + "partner":"8cqp" }, { "sim":622.0, @@ -606922,23 +609456,23 @@ }, { "sim":622.0, - "partner":"8chy" + "partner":"8cmq" }, { "sim":622.0, - "partner":"8cmq" + "partner":"8bu0" }, { "sim":622.0, - "partner":"8ckr" + "partner":"8cp8" }, { "sim":622.0, - "partner":"8cqp" + "partner":"8cqq" }, { "sim":622.0, - "partner":"8cp8" + "partner":"8chy" }, { "sim":303.0, @@ -606978,11 +609512,11 @@ }, { "sim":136.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":136.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":127.0, @@ -606998,15 +609532,15 @@ }, { "sim":94.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":94.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":94.0, - "partner":"8cus" + "partner":"8cwz" } ], "seq_thr_sim_natural":[ @@ -607038,10 +609572,6 @@ "sim":178.0, "partner":"7y4i" }, - { - "sim":178.0, - "partner":"8dtf" - }, { "sim":178.0, "partner":"8dtg" @@ -607054,6 +609584,10 @@ "sim":178.0, "partner":"8dti" }, + { + "sim":178.0, + "partner":"8dtf" + }, { "sim":164.0, "partner":"8ur5" @@ -607100,23 +609634,23 @@ }, { "sim":139.0, - "partner":"7ep7" + "partner":"4g2v" }, { "sim":139.0, - "partner":"4g2v" + "partner":"7ep7" }, { "sim":138.0, - "partner":"8a5y" + "partner":"8a3t" }, { "sim":138.0, - "partner":"8a3t" + "partner":"8a61" }, { "sim":138.0, - "partner":"8a61" + "partner":"8a5y" }, { "sim":136.0, @@ -607130,10 +609664,6 @@ "sim":131.0, "partner":"6xt9" }, - { - "sim":130.0, - "partner":"4rg6" - }, { "sim":130.0, "partner":"4rg7" @@ -607144,11 +609674,7 @@ }, { "sim":130.0, - "partner":"5lcw" - }, - { - "sim":130.0, - "partner":"6q6g" + "partner":"4rg6" }, { "sim":130.0, @@ -607172,16 +609698,12 @@ }, { "sim":130.0, - "partner":"8pkp" + "partner":"6tlj" }, { "sim":130.0, "partner":"5l9u" }, - { - "sim":130.0, - "partner":"6tlj" - }, { "sim":130.0, "partner":"6q6h" @@ -607194,6 +609716,10 @@ "sim":130.0, "partner":"5a31" }, + { + "sim":130.0, + "partner":"8pkp" + }, { "sim":130.0, "partner":"5g05" @@ -607206,25 +609732,33 @@ "sim":130.0, "partner":"4ui9" }, + { + "sim":130.0, + "partner":"6q6g" + }, { "sim":130.0, "partner":"8tau" }, + { + "sim":130.0, + "partner":"5lcw" + }, { "sim":125.0, - "partner":"6voa" + "partner":"6vbu" }, { "sim":125.0, - "partner":"6vnw" + "partner":"6vbv" }, { "sim":125.0, - "partner":"6vbu" + "partner":"6voa" }, { "sim":125.0, - "partner":"6vbv" + "partner":"6vnw" }, { "sim":122.0, @@ -607250,22 +609784,6 @@ "sim":107.0, "partner":"6tka" }, - { - "sim":106.0, - "partner":"4xif" - }, - { - "sim":106.0, - "partner":"8fe7" - }, - { - "sim":106.0, - "partner":"4gyw" - }, - { - "sim":106.0, - "partner":"5vif" - }, { "sim":106.0, "partner":"4xi9" @@ -607306,6 +609824,10 @@ "sim":106.0, "partner":"5c1d" }, + { + "sim":106.0, + "partner":"6ma1" + }, { "sim":106.0, "partner":"3pe4" @@ -607328,15 +609850,15 @@ }, { "sim":106.0, - "partner":"6ma1" + "partner":"6ma2" }, { "sim":106.0, - "partner":"4n3c" + "partner":"8fe6" }, { "sim":106.0, - "partner":"6ma2" + "partner":"4n3c" }, { "sim":106.0, @@ -607344,7 +609866,7 @@ }, { "sim":106.0, - "partner":"8fe6" + "partner":"8fuf" }, { "sim":106.0, @@ -607356,7 +609878,11 @@ }, { "sim":106.0, - "partner":"8fuf" + "partner":"8cm9" + }, + { + "sim":106.0, + "partner":"6ma5" }, { "sim":106.0, @@ -607364,11 +609890,15 @@ }, { "sim":106.0, - "partner":"8cm9" + "partner":"8fe7" }, { "sim":106.0, - "partner":"6ma5" + "partner":"6ibo" + }, + { + "sim":106.0, + "partner":"6q4m" }, { "sim":106.0, @@ -607376,11 +609906,15 @@ }, { "sim":106.0, - "partner":"6ibo" + "partner":"4xif" }, { "sim":106.0, - "partner":"6q4m" + "partner":"4gyw" + }, + { + "sim":106.0, + "partner":"5vif" }, { "sim":105.0, @@ -607438,10 +609972,6 @@ "sim":87.0, "partner":"2c0m" }, - { - "sim":87.0, - "partner":"4kyo" - }, { "sim":87.0, "partner":"3r9a" @@ -607454,6 +609984,10 @@ "sim":87.0, "partner":"4kxk" }, + { + "sim":87.0, + "partner":"4kyo" + }, { "sim":87.0, "partner":"1fch" @@ -607660,11 +610194,11 @@ }, { "sim":70.0, - "partner":"5w5i" + "partner":"5w5h" }, { "sim":70.0, - "partner":"5w5h" + "partner":"5w5i" }, { "sim":69.0, @@ -607724,11 +610258,11 @@ }, { "sim":59.0, - "partner":"7qws" + "partner":"6t59" }, { "sim":59.0, - "partner":"6t59" + "partner":"7qws" }, { "sim":59.0, @@ -607784,11 +610318,11 @@ }, { "sim":58.0, - "partner":"4i9e" + "partner":"3ulq" }, { "sim":58.0, - "partner":"3ulq" + "partner":"4i9e" }, { "sim":57.0, @@ -607904,11 +610438,11 @@ }, { "sim":55.0, - "partner":"8hmc" + "partner":"8hmd" }, { "sim":55.0, - "partner":"8hmd" + "partner":"8hmc" }, { "sim":54.0, @@ -607968,11 +610502,11 @@ }, { "sim":52.0, - "partner":"6fdp" + "partner":"6fdt" }, { "sim":52.0, - "partner":"6fdt" + "partner":"6fdp" }, { "sim":52.0, @@ -608054,7 +610588,7 @@ ], "seq_max_sim_designed":{ "sim":622.0, - "partner":"8bu0" + "partner":"8ckr" }, "seq_max_sim_natural":{ "sim":233.0, @@ -608112,86 +610646,86 @@ ], "subtitle":"Crystal structure of an 8-repeat consensus tpr superhelix with in hepes with ca", "tags":[ - "metal coordination", - "ctpr", + "polymorphism", "de novo protein", - "polymorphism" + "metal coordination", + "ctpr" ], "keywords":[ - "facile", + "form", + "crystalline", + "engineering", + "calculations", + "pofs", + "allow", + "controlled", + "responsible", + "presents", + "metal", + "negatively", + "opening", + "exposed", + "thermodynamically", + "repeat", "diverse", - "scope", - "obtained", - "density", - "despite", + "comparison", + "structurally", + "requirements", "salts", - "amino", - "proteins", + "single", + "porosity", "functional", - "frameworks", + "kinetically", + "polymorphic", "thus", - "coordination", - "presents", - "assemblies", - "pofs", - "strategy", - "single", - "stable", - "metal", - "cluster", - "calculations", - "opening", - "scaffolds", + "application", + "residues", + "preferences", + "controllable", "acid", - "negatively", - "polymorphs", - "trapped", + "scaffolds", + "addition", "finding", - "controlled", - "polymorphic", - "allow", - "residues", - "abundance", - "tetratricopeptide", + "diversity", + "strategy", + "new", + "frameworks", + "ion", + "protein", + "trapped", + "polymorphism", + "amino", "exploiting", - "direct", - "crystal", - "engineering", - "geometric", + "proteins", + "tetratricopeptide", + "achieved", + "cluster", + "polymorphs", "innate", - "kinetically", - "application", - "addition", - "polymorphism", - "increasingly", - "comparison", - "protein", - "controllable", - "biocompatible", - "applications", - "states", - "requirements", - "negative", - "charged", - "theory", - "structurally", - "responsible", - "repeat", "showed", - "diversity", - "thermodynamically", - "minimal", "varying", - "crystalline", - "form", - "porosity", - "achieved", - "preferences", - "exposed", + "direct", "consensus", + "coordination", + "charged", + "biocompatible", + "negative", + "states", + "scope", "crystals", - "ion", - "new" + "increasingly", + "density", + "despite", + "applications", + "crystal", + "stable", + "theory", + "assemblies", + "minimal", + "abundance", + "obtained", + "geometric", + "facile" ], "release_date":"2024-02-28", "publication":"\"Diverse crystalline protein scaffolds through metal-dependent polymorphism\", Protein Sci., 33, e4971-e4971", @@ -608224,35 +610758,35 @@ "seq_thr_sim_designed":[ { "sim":622.0, - "partner":"8bu0" + "partner":"8cqp" }, { "sim":622.0, - "partner":"8cqq" + "partner":"8ot7" }, { "sim":622.0, - "partner":"8ot7" + "partner":"8cmq" }, { "sim":622.0, - "partner":"8chy" + "partner":"8bu0" }, { "sim":622.0, - "partner":"8cmq" + "partner":"8cp8" }, { "sim":622.0, - "partner":"8cig" + "partner":"8cqq" }, { "sim":622.0, - "partner":"8cqp" + "partner":"8chy" }, { "sim":622.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":303.0, @@ -608292,11 +610826,11 @@ }, { "sim":136.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":136.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":127.0, @@ -608312,15 +610846,15 @@ }, { "sim":94.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":94.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":94.0, - "partner":"8cus" + "partner":"8cwz" } ], "seq_thr_sim_natural":[ @@ -608352,10 +610886,6 @@ "sim":178.0, "partner":"7y4i" }, - { - "sim":178.0, - "partner":"8dtf" - }, { "sim":178.0, "partner":"8dtg" @@ -608368,6 +610898,10 @@ "sim":178.0, "partner":"8dti" }, + { + "sim":178.0, + "partner":"8dtf" + }, { "sim":164.0, "partner":"8ur5" @@ -608414,23 +610948,23 @@ }, { "sim":139.0, - "partner":"7ep7" + "partner":"4g2v" }, { "sim":139.0, - "partner":"4g2v" + "partner":"7ep7" }, { "sim":138.0, - "partner":"8a5y" + "partner":"8a3t" }, { "sim":138.0, - "partner":"8a3t" + "partner":"8a61" }, { "sim":138.0, - "partner":"8a61" + "partner":"8a5y" }, { "sim":136.0, @@ -608444,10 +610978,6 @@ "sim":131.0, "partner":"6xt9" }, - { - "sim":130.0, - "partner":"4rg6" - }, { "sim":130.0, "partner":"4rg7" @@ -608458,11 +610988,7 @@ }, { "sim":130.0, - "partner":"5lcw" - }, - { - "sim":130.0, - "partner":"6q6g" + "partner":"4rg6" }, { "sim":130.0, @@ -608486,16 +611012,12 @@ }, { "sim":130.0, - "partner":"8pkp" + "partner":"6tlj" }, { "sim":130.0, "partner":"5l9u" }, - { - "sim":130.0, - "partner":"6tlj" - }, { "sim":130.0, "partner":"6q6h" @@ -608508,6 +611030,10 @@ "sim":130.0, "partner":"5a31" }, + { + "sim":130.0, + "partner":"8pkp" + }, { "sim":130.0, "partner":"5g05" @@ -608520,25 +611046,33 @@ "sim":130.0, "partner":"4ui9" }, + { + "sim":130.0, + "partner":"6q6g" + }, { "sim":130.0, "partner":"8tau" }, + { + "sim":130.0, + "partner":"5lcw" + }, { "sim":125.0, - "partner":"6voa" + "partner":"6vbu" }, { "sim":125.0, - "partner":"6vnw" + "partner":"6vbv" }, { "sim":125.0, - "partner":"6vbu" + "partner":"6voa" }, { "sim":125.0, - "partner":"6vbv" + "partner":"6vnw" }, { "sim":122.0, @@ -608564,22 +611098,6 @@ "sim":107.0, "partner":"6tka" }, - { - "sim":106.0, - "partner":"4xif" - }, - { - "sim":106.0, - "partner":"8fe7" - }, - { - "sim":106.0, - "partner":"4gyw" - }, - { - "sim":106.0, - "partner":"5vif" - }, { "sim":106.0, "partner":"4xi9" @@ -608620,6 +611138,10 @@ "sim":106.0, "partner":"5c1d" }, + { + "sim":106.0, + "partner":"6ma1" + }, { "sim":106.0, "partner":"3pe4" @@ -608642,15 +611164,15 @@ }, { "sim":106.0, - "partner":"6ma1" + "partner":"6ma2" }, { "sim":106.0, - "partner":"4n3c" + "partner":"8fe6" }, { "sim":106.0, - "partner":"6ma2" + "partner":"4n3c" }, { "sim":106.0, @@ -608658,7 +611180,7 @@ }, { "sim":106.0, - "partner":"8fe6" + "partner":"8fuf" }, { "sim":106.0, @@ -608670,7 +611192,11 @@ }, { "sim":106.0, - "partner":"8fuf" + "partner":"8cm9" + }, + { + "sim":106.0, + "partner":"6ma5" }, { "sim":106.0, @@ -608678,11 +611204,15 @@ }, { "sim":106.0, - "partner":"8cm9" + "partner":"8fe7" }, { "sim":106.0, - "partner":"6ma5" + "partner":"6ibo" + }, + { + "sim":106.0, + "partner":"6q4m" }, { "sim":106.0, @@ -608690,11 +611220,15 @@ }, { "sim":106.0, - "partner":"6ibo" + "partner":"4xif" }, { "sim":106.0, - "partner":"6q4m" + "partner":"4gyw" + }, + { + "sim":106.0, + "partner":"5vif" }, { "sim":105.0, @@ -608752,10 +611286,6 @@ "sim":87.0, "partner":"2c0m" }, - { - "sim":87.0, - "partner":"4kyo" - }, { "sim":87.0, "partner":"3r9a" @@ -608768,6 +611298,10 @@ "sim":87.0, "partner":"4kxk" }, + { + "sim":87.0, + "partner":"4kyo" + }, { "sim":87.0, "partner":"1fch" @@ -608974,11 +611508,11 @@ }, { "sim":70.0, - "partner":"5w5i" + "partner":"5w5h" }, { "sim":70.0, - "partner":"5w5h" + "partner":"5w5i" }, { "sim":69.0, @@ -609038,11 +611572,11 @@ }, { "sim":59.0, - "partner":"7qws" + "partner":"6t59" }, { "sim":59.0, - "partner":"6t59" + "partner":"7qws" }, { "sim":59.0, @@ -609098,11 +611632,11 @@ }, { "sim":58.0, - "partner":"4i9e" + "partner":"3ulq" }, { "sim":58.0, - "partner":"3ulq" + "partner":"4i9e" }, { "sim":57.0, @@ -609218,11 +611752,11 @@ }, { "sim":55.0, - "partner":"8hmc" + "partner":"8hmd" }, { "sim":55.0, - "partner":"8hmd" + "partner":"8hmc" }, { "sim":54.0, @@ -609282,11 +611816,11 @@ }, { "sim":52.0, - "partner":"6fdp" + "partner":"6fdt" }, { "sim":52.0, - "partner":"6fdt" + "partner":"6fdp" }, { "sim":52.0, @@ -609368,7 +611902,7 @@ ], "seq_max_sim_designed":{ "sim":622.0, - "partner":"8bu0" + "partner":"8cqp" }, "seq_max_sim_natural":{ "sim":233.0, @@ -609426,86 +611960,86 @@ ], "subtitle":"Crystal structure of an 8-repeat consensus tpr superhelix with tb", "tags":[ - "metal coordination", - "ctpr", + "polymorphism", "de novo protein", - "polymorphism" + "metal coordination", + "ctpr" ], "keywords":[ - "facile", + "form", + "crystalline", + "engineering", + "calculations", + "pofs", + "allow", + "controlled", + "responsible", + "presents", + "metal", + "negatively", + "opening", + "exposed", + "thermodynamically", + "repeat", "diverse", - "scope", - "obtained", - "density", - "despite", + "comparison", + "structurally", + "requirements", "salts", - "amino", - "proteins", + "single", + "porosity", "functional", - "frameworks", + "kinetically", + "polymorphic", "thus", - "coordination", - "presents", - "assemblies", - "pofs", - "strategy", - "single", - "stable", - "metal", - "cluster", - "calculations", - "opening", - "scaffolds", + "application", + "residues", + "preferences", + "controllable", "acid", - "negatively", - "polymorphs", - "trapped", + "scaffolds", + "addition", "finding", - "controlled", - "polymorphic", - "allow", - "residues", - "abundance", - "tetratricopeptide", + "diversity", + "strategy", + "new", + "frameworks", + "ion", + "protein", + "trapped", + "polymorphism", + "amino", "exploiting", - "direct", - "crystal", - "engineering", - "geometric", + "proteins", + "tetratricopeptide", + "achieved", + "cluster", + "polymorphs", "innate", - "kinetically", - "application", - "addition", - "polymorphism", - "increasingly", - "comparison", - "protein", - "controllable", - "biocompatible", - "applications", - "states", - "requirements", - "negative", - "charged", - "theory", - "structurally", - "responsible", - "repeat", "showed", - "diversity", - "thermodynamically", - "minimal", "varying", - "crystalline", - "form", - "porosity", - "achieved", - "preferences", - "exposed", + "direct", "consensus", + "coordination", + "charged", + "biocompatible", + "negative", + "states", + "scope", "crystals", - "ion", - "new" + "increasingly", + "density", + "despite", + "applications", + "crystal", + "stable", + "theory", + "assemblies", + "minimal", + "abundance", + "obtained", + "geometric", + "facile" ], "release_date":"2024-03-06", "publication":"\"Diverse crystalline protein scaffolds through metal-dependent polymorphism\", Protein Sci., 33, e4971-e4971", @@ -609538,11 +612072,11 @@ "seq_thr_sim_designed":[ { "sim":622.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":622.0, - "partner":"8cqq" + "partner":"8cqp" }, { "sim":622.0, @@ -609550,23 +612084,23 @@ }, { "sim":622.0, - "partner":"8chy" + "partner":"8bu0" }, { "sim":622.0, - "partner":"8ckr" + "partner":"8cp8" }, { "sim":622.0, - "partner":"8cig" + "partner":"8cqq" }, { "sim":622.0, - "partner":"8cqp" + "partner":"8chy" }, { "sim":622.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":303.0, @@ -609606,11 +612140,11 @@ }, { "sim":136.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":136.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":127.0, @@ -609626,15 +612160,15 @@ }, { "sim":94.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":94.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":94.0, - "partner":"8cus" + "partner":"8cwz" } ], "seq_thr_sim_natural":[ @@ -609666,10 +612200,6 @@ "sim":178.0, "partner":"7y4i" }, - { - "sim":178.0, - "partner":"8dtf" - }, { "sim":178.0, "partner":"8dtg" @@ -609682,6 +612212,10 @@ "sim":178.0, "partner":"8dti" }, + { + "sim":178.0, + "partner":"8dtf" + }, { "sim":164.0, "partner":"8ur5" @@ -609728,23 +612262,23 @@ }, { "sim":139.0, - "partner":"7ep7" + "partner":"4g2v" }, { "sim":139.0, - "partner":"4g2v" + "partner":"7ep7" }, { "sim":138.0, - "partner":"8a5y" + "partner":"8a3t" }, { "sim":138.0, - "partner":"8a3t" + "partner":"8a61" }, { "sim":138.0, - "partner":"8a61" + "partner":"8a5y" }, { "sim":136.0, @@ -609758,10 +612292,6 @@ "sim":131.0, "partner":"6xt9" }, - { - "sim":130.0, - "partner":"4rg6" - }, { "sim":130.0, "partner":"4rg7" @@ -609772,11 +612302,7 @@ }, { "sim":130.0, - "partner":"5lcw" - }, - { - "sim":130.0, - "partner":"6q6g" + "partner":"4rg6" }, { "sim":130.0, @@ -609800,16 +612326,12 @@ }, { "sim":130.0, - "partner":"8pkp" + "partner":"6tlj" }, { "sim":130.0, "partner":"5l9u" }, - { - "sim":130.0, - "partner":"6tlj" - }, { "sim":130.0, "partner":"6q6h" @@ -609822,6 +612344,10 @@ "sim":130.0, "partner":"5a31" }, + { + "sim":130.0, + "partner":"8pkp" + }, { "sim":130.0, "partner":"5g05" @@ -609834,25 +612360,33 @@ "sim":130.0, "partner":"4ui9" }, + { + "sim":130.0, + "partner":"6q6g" + }, { "sim":130.0, "partner":"8tau" }, + { + "sim":130.0, + "partner":"5lcw" + }, { "sim":125.0, - "partner":"6voa" + "partner":"6vbu" }, { "sim":125.0, - "partner":"6vnw" + "partner":"6vbv" }, { "sim":125.0, - "partner":"6vbu" + "partner":"6voa" }, { "sim":125.0, - "partner":"6vbv" + "partner":"6vnw" }, { "sim":122.0, @@ -609878,22 +612412,6 @@ "sim":107.0, "partner":"6tka" }, - { - "sim":106.0, - "partner":"4xif" - }, - { - "sim":106.0, - "partner":"8fe7" - }, - { - "sim":106.0, - "partner":"4gyw" - }, - { - "sim":106.0, - "partner":"5vif" - }, { "sim":106.0, "partner":"4xi9" @@ -609934,6 +612452,10 @@ "sim":106.0, "partner":"5c1d" }, + { + "sim":106.0, + "partner":"6ma1" + }, { "sim":106.0, "partner":"3pe4" @@ -609956,15 +612478,15 @@ }, { "sim":106.0, - "partner":"6ma1" + "partner":"6ma2" }, { "sim":106.0, - "partner":"4n3c" + "partner":"8fe6" }, { "sim":106.0, - "partner":"6ma2" + "partner":"4n3c" }, { "sim":106.0, @@ -609972,7 +612494,7 @@ }, { "sim":106.0, - "partner":"8fe6" + "partner":"8fuf" }, { "sim":106.0, @@ -609984,7 +612506,11 @@ }, { "sim":106.0, - "partner":"8fuf" + "partner":"8cm9" + }, + { + "sim":106.0, + "partner":"6ma5" }, { "sim":106.0, @@ -609992,11 +612518,15 @@ }, { "sim":106.0, - "partner":"8cm9" + "partner":"8fe7" }, { "sim":106.0, - "partner":"6ma5" + "partner":"6ibo" + }, + { + "sim":106.0, + "partner":"6q4m" }, { "sim":106.0, @@ -610004,11 +612534,15 @@ }, { "sim":106.0, - "partner":"6ibo" + "partner":"4xif" }, { "sim":106.0, - "partner":"6q4m" + "partner":"4gyw" + }, + { + "sim":106.0, + "partner":"5vif" }, { "sim":105.0, @@ -610066,10 +612600,6 @@ "sim":87.0, "partner":"2c0m" }, - { - "sim":87.0, - "partner":"4kyo" - }, { "sim":87.0, "partner":"3r9a" @@ -610082,6 +612612,10 @@ "sim":87.0, "partner":"4kxk" }, + { + "sim":87.0, + "partner":"4kyo" + }, { "sim":87.0, "partner":"1fch" @@ -610288,11 +612822,11 @@ }, { "sim":70.0, - "partner":"5w5i" + "partner":"5w5h" }, { "sim":70.0, - "partner":"5w5h" + "partner":"5w5i" }, { "sim":69.0, @@ -610356,11 +612890,11 @@ }, { "sim":59.0, - "partner":"7qws" + "partner":"6t59" }, { "sim":59.0, - "partner":"6t59" + "partner":"7qws" }, { "sim":59.0, @@ -610416,11 +612950,11 @@ }, { "sim":58.0, - "partner":"4i9e" + "partner":"3ulq" }, { "sim":58.0, - "partner":"3ulq" + "partner":"4i9e" }, { "sim":57.0, @@ -610536,11 +613070,11 @@ }, { "sim":55.0, - "partner":"8hmc" + "partner":"8hmd" }, { "sim":55.0, - "partner":"8hmd" + "partner":"8hmc" }, { "sim":54.0, @@ -610604,11 +613138,11 @@ }, { "sim":52.0, - "partner":"6fdp" + "partner":"6fdt" }, { "sim":52.0, - "partner":"6fdt" + "partner":"6fdp" }, { "sim":52.0, @@ -610686,7 +613220,7 @@ ], "seq_max_sim_designed":{ "sim":622.0, - "partner":"8bu0" + "partner":"8ckr" }, "seq_max_sim_natural":{ "sim":233.0, @@ -610744,86 +613278,86 @@ ], "subtitle":"Crystal structure of an 8-repeat consensus tpr superhelix with lead", "tags":[ - "metal coordination", - "ctpr", + "polymorphism", "de novo protein", - "polymorphism" + "metal coordination", + "ctpr" ], "keywords":[ - "facile", + "form", + "crystalline", + "engineering", + "calculations", + "pofs", + "allow", + "controlled", + "responsible", + "presents", + "metal", + "negatively", + "opening", + "exposed", + "thermodynamically", + "repeat", "diverse", - "scope", - "obtained", - "density", - "despite", + "comparison", + "structurally", + "requirements", "salts", - "amino", - "proteins", + "single", + "porosity", "functional", - "frameworks", + "kinetically", + "polymorphic", "thus", - "coordination", - "presents", - "assemblies", - "pofs", - "strategy", - "single", - "stable", - "metal", - "cluster", - "calculations", - "opening", - "scaffolds", + "application", + "residues", + "preferences", + "controllable", "acid", - "negatively", - "polymorphs", - "trapped", + "scaffolds", + "addition", "finding", - "controlled", - "polymorphic", - "allow", - "residues", - "abundance", - "tetratricopeptide", + "diversity", + "strategy", + "new", + "frameworks", + "ion", + "protein", + "trapped", + "polymorphism", + "amino", "exploiting", - "direct", - "crystal", - "engineering", - "geometric", + "proteins", + "tetratricopeptide", + "achieved", + "cluster", + "polymorphs", "innate", - "kinetically", - "application", - "addition", - "polymorphism", - "increasingly", - "comparison", - "protein", - "controllable", - "biocompatible", - "applications", - "states", - "requirements", - "negative", - "charged", - "theory", - "structurally", - "responsible", - "repeat", "showed", - "diversity", - "thermodynamically", - "minimal", "varying", - "crystalline", - "form", - "porosity", - "achieved", - "preferences", - "exposed", + "direct", "consensus", + "coordination", + "charged", + "biocompatible", + "negative", + "states", + "scope", "crystals", - "ion", - "new" + "increasingly", + "density", + "despite", + "applications", + "crystal", + "stable", + "theory", + "assemblies", + "minimal", + "abundance", + "obtained", + "geometric", + "facile" ], "release_date":"2024-03-13", "publication":"\"Diverse crystalline protein scaffolds through metal-dependent polymorphism\", Protein Sci., 33, e4971-e4971", @@ -610856,11 +613390,11 @@ "seq_thr_sim_designed":[ { "sim":622.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":622.0, - "partner":"8cqq" + "partner":"8cqp" }, { "sim":622.0, @@ -610868,23 +613402,23 @@ }, { "sim":622.0, - "partner":"8chy" + "partner":"8cmq" }, { "sim":622.0, - "partner":"8cmq" + "partner":"8bu0" }, { "sim":622.0, - "partner":"8ckr" + "partner":"8cqq" }, { "sim":622.0, - "partner":"8cig" + "partner":"8chy" }, { "sim":622.0, - "partner":"8cqp" + "partner":"8cig" }, { "sim":303.0, @@ -610924,11 +613458,11 @@ }, { "sim":136.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":136.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":127.0, @@ -610944,15 +613478,15 @@ }, { "sim":94.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":94.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":94.0, - "partner":"8cus" + "partner":"8cwz" } ], "seq_thr_sim_natural":[ @@ -610984,10 +613518,6 @@ "sim":178.0, "partner":"7y4i" }, - { - "sim":178.0, - "partner":"8dtf" - }, { "sim":178.0, "partner":"8dtg" @@ -611000,6 +613530,10 @@ "sim":178.0, "partner":"8dti" }, + { + "sim":178.0, + "partner":"8dtf" + }, { "sim":164.0, "partner":"8ur5" @@ -611046,23 +613580,23 @@ }, { "sim":139.0, - "partner":"7ep7" + "partner":"4g2v" }, { "sim":139.0, - "partner":"4g2v" + "partner":"7ep7" }, { "sim":138.0, - "partner":"8a5y" + "partner":"8a3t" }, { "sim":138.0, - "partner":"8a3t" + "partner":"8a61" }, { "sim":138.0, - "partner":"8a61" + "partner":"8a5y" }, { "sim":136.0, @@ -611076,10 +613610,6 @@ "sim":131.0, "partner":"6xt9" }, - { - "sim":130.0, - "partner":"4rg6" - }, { "sim":130.0, "partner":"4rg7" @@ -611090,11 +613620,7 @@ }, { "sim":130.0, - "partner":"5lcw" - }, - { - "sim":130.0, - "partner":"6q6g" + "partner":"4rg6" }, { "sim":130.0, @@ -611118,16 +613644,12 @@ }, { "sim":130.0, - "partner":"8pkp" + "partner":"6tlj" }, { "sim":130.0, "partner":"5l9u" }, - { - "sim":130.0, - "partner":"6tlj" - }, { "sim":130.0, "partner":"6q6h" @@ -611140,6 +613662,10 @@ "sim":130.0, "partner":"5a31" }, + { + "sim":130.0, + "partner":"8pkp" + }, { "sim":130.0, "partner":"5g05" @@ -611152,25 +613678,33 @@ "sim":130.0, "partner":"4ui9" }, + { + "sim":130.0, + "partner":"6q6g" + }, { "sim":130.0, "partner":"8tau" }, + { + "sim":130.0, + "partner":"5lcw" + }, { "sim":125.0, - "partner":"6voa" + "partner":"6vbu" }, { "sim":125.0, - "partner":"6vnw" + "partner":"6vbv" }, { "sim":125.0, - "partner":"6vbu" + "partner":"6voa" }, { "sim":125.0, - "partner":"6vbv" + "partner":"6vnw" }, { "sim":122.0, @@ -611196,22 +613730,6 @@ "sim":107.0, "partner":"6tka" }, - { - "sim":106.0, - "partner":"4xif" - }, - { - "sim":106.0, - "partner":"8fe7" - }, - { - "sim":106.0, - "partner":"4gyw" - }, - { - "sim":106.0, - "partner":"5vif" - }, { "sim":106.0, "partner":"4xi9" @@ -611252,6 +613770,10 @@ "sim":106.0, "partner":"5c1d" }, + { + "sim":106.0, + "partner":"6ma1" + }, { "sim":106.0, "partner":"3pe4" @@ -611274,15 +613796,15 @@ }, { "sim":106.0, - "partner":"6ma1" + "partner":"6ma2" }, { "sim":106.0, - "partner":"4n3c" + "partner":"8fe6" }, { "sim":106.0, - "partner":"6ma2" + "partner":"4n3c" }, { "sim":106.0, @@ -611290,7 +613812,7 @@ }, { "sim":106.0, - "partner":"8fe6" + "partner":"8fuf" }, { "sim":106.0, @@ -611302,7 +613824,11 @@ }, { "sim":106.0, - "partner":"8fuf" + "partner":"8cm9" + }, + { + "sim":106.0, + "partner":"6ma5" }, { "sim":106.0, @@ -611310,11 +613836,15 @@ }, { "sim":106.0, - "partner":"8cm9" + "partner":"8fe7" }, { "sim":106.0, - "partner":"6ma5" + "partner":"6ibo" + }, + { + "sim":106.0, + "partner":"6q4m" }, { "sim":106.0, @@ -611322,11 +613852,15 @@ }, { "sim":106.0, - "partner":"6ibo" + "partner":"4xif" }, { "sim":106.0, - "partner":"6q4m" + "partner":"4gyw" + }, + { + "sim":106.0, + "partner":"5vif" }, { "sim":105.0, @@ -611384,10 +613918,6 @@ "sim":87.0, "partner":"2c0m" }, - { - "sim":87.0, - "partner":"4kyo" - }, { "sim":87.0, "partner":"3r9a" @@ -611400,6 +613930,10 @@ "sim":87.0, "partner":"4kxk" }, + { + "sim":87.0, + "partner":"4kyo" + }, { "sim":87.0, "partner":"1fch" @@ -611606,11 +614140,11 @@ }, { "sim":70.0, - "partner":"5w5i" + "partner":"5w5h" }, { "sim":70.0, - "partner":"5w5h" + "partner":"5w5i" }, { "sim":69.0, @@ -611674,11 +614208,11 @@ }, { "sim":59.0, - "partner":"7qws" + "partner":"6t59" }, { "sim":59.0, - "partner":"6t59" + "partner":"7qws" }, { "sim":59.0, @@ -611734,11 +614268,11 @@ }, { "sim":58.0, - "partner":"4i9e" + "partner":"3ulq" }, { "sim":58.0, - "partner":"3ulq" + "partner":"4i9e" }, { "sim":57.0, @@ -611854,11 +614388,11 @@ }, { "sim":55.0, - "partner":"8hmc" + "partner":"8hmd" }, { "sim":55.0, - "partner":"8hmd" + "partner":"8hmc" }, { "sim":54.0, @@ -611922,11 +614456,11 @@ }, { "sim":52.0, - "partner":"6fdp" + "partner":"6fdt" }, { "sim":52.0, - "partner":"6fdt" + "partner":"6fdp" }, { "sim":52.0, @@ -612008,7 +614542,7 @@ ], "seq_max_sim_designed":{ "sim":622.0, - "partner":"8bu0" + "partner":"8ckr" }, "seq_max_sim_natural":{ "sim":233.0, @@ -612066,86 +614600,86 @@ ], "subtitle":"Crystal structure of an 8-repeat consensus tpr superhelix with calcium (low concentration)", "tags":[ - "metal coordination", - "ctpr", + "polymorphism", "de novo protein", - "polymorphism" + "metal coordination", + "ctpr" ], "keywords":[ - "facile", + "form", + "crystalline", + "engineering", + "calculations", + "pofs", + "allow", + "controlled", + "responsible", + "presents", + "metal", + "negatively", + "opening", + "exposed", + "thermodynamically", + "repeat", "diverse", - "scope", - "obtained", - "density", - "despite", + "comparison", + "structurally", + "requirements", "salts", - "amino", - "proteins", + "single", + "porosity", "functional", - "frameworks", + "kinetically", + "polymorphic", "thus", - "coordination", - "presents", - "assemblies", - "pofs", - "strategy", - "single", - "stable", - "metal", - "cluster", - "calculations", - "opening", - "scaffolds", + "application", + "residues", + "preferences", + "controllable", "acid", - "negatively", - "polymorphs", - "trapped", + "scaffolds", + "addition", "finding", - "controlled", - "polymorphic", - "allow", - "residues", - "abundance", - "tetratricopeptide", + "diversity", + "strategy", + "new", + "frameworks", + "ion", + "protein", + "trapped", + "polymorphism", + "amino", "exploiting", - "direct", - "crystal", - "engineering", - "geometric", + "proteins", + "tetratricopeptide", + "achieved", + "cluster", + "polymorphs", "innate", - "kinetically", - "application", - "addition", - "polymorphism", - "increasingly", - "comparison", - "protein", - "controllable", - "biocompatible", - "applications", - "states", - "requirements", - "negative", - "charged", - "theory", - "structurally", - "responsible", - "repeat", "showed", - "diversity", - "thermodynamically", - "minimal", "varying", - "crystalline", - "form", - "porosity", - "achieved", - "preferences", - "exposed", + "direct", "consensus", + "coordination", + "charged", + "biocompatible", + "negative", + "states", + "scope", "crystals", - "ion", - "new" + "increasingly", + "density", + "despite", + "applications", + "crystal", + "stable", + "theory", + "assemblies", + "minimal", + "abundance", + "obtained", + "geometric", + "facile" ], "release_date":"2024-03-27", "publication":"\"Diverse crystalline protein scaffolds through metal-dependent polymorphism\", Protein Sci., 33, e4971-e4971", @@ -612178,35 +614712,35 @@ "seq_thr_sim_designed":[ { "sim":622.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":622.0, - "partner":"8cqq" + "partner":"8ot7" }, { "sim":622.0, - "partner":"8ot7" + "partner":"8cmq" }, { "sim":622.0, - "partner":"8chy" + "partner":"8bu0" }, { "sim":622.0, - "partner":"8cmq" + "partner":"8cp8" }, { "sim":622.0, - "partner":"8ckr" + "partner":"8cqq" }, { "sim":622.0, - "partner":"8cig" + "partner":"8chy" }, { "sim":622.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":303.0, @@ -612246,11 +614780,11 @@ }, { "sim":136.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":136.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":127.0, @@ -612266,15 +614800,15 @@ }, { "sim":94.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":94.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":94.0, - "partner":"8cus" + "partner":"8cwz" } ], "seq_thr_sim_natural":[ @@ -612306,10 +614840,6 @@ "sim":178.0, "partner":"7y4i" }, - { - "sim":178.0, - "partner":"8dtf" - }, { "sim":178.0, "partner":"8dtg" @@ -612322,6 +614852,10 @@ "sim":178.0, "partner":"8dti" }, + { + "sim":178.0, + "partner":"8dtf" + }, { "sim":164.0, "partner":"8ur5" @@ -612368,23 +614902,23 @@ }, { "sim":139.0, - "partner":"7ep7" + "partner":"4g2v" }, { "sim":139.0, - "partner":"4g2v" + "partner":"7ep7" }, { "sim":138.0, - "partner":"8a5y" + "partner":"8a3t" }, { "sim":138.0, - "partner":"8a3t" + "partner":"8a61" }, { "sim":138.0, - "partner":"8a61" + "partner":"8a5y" }, { "sim":136.0, @@ -612398,10 +614932,6 @@ "sim":131.0, "partner":"6xt9" }, - { - "sim":130.0, - "partner":"4rg6" - }, { "sim":130.0, "partner":"4rg7" @@ -612412,11 +614942,7 @@ }, { "sim":130.0, - "partner":"5lcw" - }, - { - "sim":130.0, - "partner":"6q6g" + "partner":"4rg6" }, { "sim":130.0, @@ -612440,16 +614966,12 @@ }, { "sim":130.0, - "partner":"8pkp" + "partner":"6tlj" }, { "sim":130.0, "partner":"5l9u" }, - { - "sim":130.0, - "partner":"6tlj" - }, { "sim":130.0, "partner":"6q6h" @@ -612462,6 +614984,10 @@ "sim":130.0, "partner":"5a31" }, + { + "sim":130.0, + "partner":"8pkp" + }, { "sim":130.0, "partner":"5g05" @@ -612474,25 +615000,33 @@ "sim":130.0, "partner":"4ui9" }, + { + "sim":130.0, + "partner":"6q6g" + }, { "sim":130.0, "partner":"8tau" }, + { + "sim":130.0, + "partner":"5lcw" + }, { "sim":125.0, - "partner":"6voa" + "partner":"6vbu" }, { "sim":125.0, - "partner":"6vnw" + "partner":"6vbv" }, { "sim":125.0, - "partner":"6vbu" + "partner":"6voa" }, { "sim":125.0, - "partner":"6vbv" + "partner":"6vnw" }, { "sim":122.0, @@ -612518,22 +615052,6 @@ "sim":107.0, "partner":"6tka" }, - { - "sim":106.0, - "partner":"4xif" - }, - { - "sim":106.0, - "partner":"8fe7" - }, - { - "sim":106.0, - "partner":"4gyw" - }, - { - "sim":106.0, - "partner":"5vif" - }, { "sim":106.0, "partner":"4xi9" @@ -612574,6 +615092,10 @@ "sim":106.0, "partner":"5c1d" }, + { + "sim":106.0, + "partner":"6ma1" + }, { "sim":106.0, "partner":"3pe4" @@ -612596,15 +615118,15 @@ }, { "sim":106.0, - "partner":"6ma1" + "partner":"6ma2" }, { "sim":106.0, - "partner":"4n3c" + "partner":"8fe6" }, { "sim":106.0, - "partner":"6ma2" + "partner":"4n3c" }, { "sim":106.0, @@ -612612,7 +615134,7 @@ }, { "sim":106.0, - "partner":"8fe6" + "partner":"8fuf" }, { "sim":106.0, @@ -612624,7 +615146,11 @@ }, { "sim":106.0, - "partner":"8fuf" + "partner":"8cm9" + }, + { + "sim":106.0, + "partner":"6ma5" }, { "sim":106.0, @@ -612632,11 +615158,15 @@ }, { "sim":106.0, - "partner":"8cm9" + "partner":"8fe7" }, { "sim":106.0, - "partner":"6ma5" + "partner":"6ibo" + }, + { + "sim":106.0, + "partner":"6q4m" }, { "sim":106.0, @@ -612644,11 +615174,15 @@ }, { "sim":106.0, - "partner":"6ibo" + "partner":"4xif" }, { "sim":106.0, - "partner":"6q4m" + "partner":"4gyw" + }, + { + "sim":106.0, + "partner":"5vif" }, { "sim":105.0, @@ -612706,10 +615240,6 @@ "sim":87.0, "partner":"2c0m" }, - { - "sim":87.0, - "partner":"4kyo" - }, { "sim":87.0, "partner":"3r9a" @@ -612722,6 +615252,10 @@ "sim":87.0, "partner":"4kxk" }, + { + "sim":87.0, + "partner":"4kyo" + }, { "sim":87.0, "partner":"1fch" @@ -612928,11 +615462,11 @@ }, { "sim":70.0, - "partner":"5w5i" + "partner":"5w5h" }, { "sim":70.0, - "partner":"5w5h" + "partner":"5w5i" }, { "sim":69.0, @@ -612996,11 +615530,11 @@ }, { "sim":59.0, - "partner":"7qws" + "partner":"6t59" }, { "sim":59.0, - "partner":"6t59" + "partner":"7qws" }, { "sim":59.0, @@ -613056,11 +615590,11 @@ }, { "sim":58.0, - "partner":"4i9e" + "partner":"3ulq" }, { "sim":58.0, - "partner":"3ulq" + "partner":"4i9e" }, { "sim":57.0, @@ -613180,11 +615714,11 @@ }, { "sim":55.0, - "partner":"8hmc" + "partner":"8hmd" }, { "sim":55.0, - "partner":"8hmd" + "partner":"8hmc" }, { "sim":54.0, @@ -613248,11 +615782,11 @@ }, { "sim":52.0, - "partner":"6fdp" + "partner":"6fdt" }, { "sim":52.0, - "partner":"6fdt" + "partner":"6fdp" }, { "sim":52.0, @@ -613334,7 +615868,7 @@ ], "seq_max_sim_designed":{ "sim":622.0, - "partner":"8bu0" + "partner":"8ckr" }, "seq_max_sim_natural":{ "sim":233.0, @@ -613392,86 +615926,86 @@ ], "subtitle":"Crystal structure of an 8-repeat consensus tpr superhelix with copper", "tags":[ - "metal coordination", - "ctpr", + "polymorphism", "de novo protein", - "polymorphism" + "metal coordination", + "ctpr" ], "keywords":[ - "facile", + "form", + "crystalline", + "engineering", + "calculations", + "pofs", + "allow", + "controlled", + "responsible", + "presents", + "metal", + "negatively", + "opening", + "exposed", + "thermodynamically", + "repeat", "diverse", - "scope", - "obtained", - "density", - "despite", + "comparison", + "structurally", + "requirements", "salts", - "amino", - "proteins", + "single", + "porosity", "functional", - "frameworks", + "kinetically", + "polymorphic", "thus", - "coordination", - "presents", - "assemblies", - "pofs", - "strategy", - "single", - "stable", - "metal", - "cluster", - "calculations", - "opening", - "scaffolds", + "application", + "residues", + "preferences", + "controllable", "acid", - "negatively", - "polymorphs", - "trapped", + "scaffolds", + "addition", "finding", - "controlled", - "polymorphic", - "allow", - "residues", - "abundance", - "tetratricopeptide", + "diversity", + "strategy", + "new", + "frameworks", + "ion", + "protein", + "trapped", + "polymorphism", + "amino", "exploiting", - "direct", - "crystal", - "engineering", - "geometric", + "proteins", + "tetratricopeptide", + "achieved", + "cluster", + "polymorphs", "innate", - "kinetically", - "application", - "addition", - "polymorphism", - "increasingly", - "comparison", - "protein", - "controllable", - "biocompatible", - "applications", - "states", - "requirements", - "negative", - "charged", - "theory", - "structurally", - "responsible", - "repeat", "showed", - "diversity", - "thermodynamically", - "minimal", "varying", - "crystalline", - "form", - "porosity", - "achieved", - "preferences", - "exposed", + "direct", "consensus", + "coordination", + "charged", + "biocompatible", + "negative", + "states", + "scope", "crystals", - "ion", - "new" + "increasingly", + "density", + "despite", + "applications", + "crystal", + "stable", + "theory", + "assemblies", + "minimal", + "abundance", + "obtained", + "geometric", + "facile" ], "release_date":"2024-03-27", "publication":"\"Diverse crystalline protein scaffolds through metal-dependent polymorphism\", Protein Sci., 33, e4971-e4971", @@ -613504,15 +616038,15 @@ "seq_thr_sim_designed":[ { "sim":622.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":622.0, - "partner":"8ot7" + "partner":"8cqp" }, { "sim":622.0, - "partner":"8chy" + "partner":"8ot7" }, { "sim":622.0, @@ -613520,19 +616054,19 @@ }, { "sim":622.0, - "partner":"8ckr" + "partner":"8bu0" }, { "sim":622.0, - "partner":"8cig" + "partner":"8cp8" }, { "sim":622.0, - "partner":"8cqp" + "partner":"8chy" }, { "sim":622.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":303.0, @@ -613572,11 +616106,11 @@ }, { "sim":136.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":136.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":127.0, @@ -613592,15 +616126,15 @@ }, { "sim":94.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":94.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":94.0, - "partner":"8cus" + "partner":"8cwz" } ], "seq_thr_sim_natural":[ @@ -613632,10 +616166,6 @@ "sim":178.0, "partner":"7y4i" }, - { - "sim":178.0, - "partner":"8dtf" - }, { "sim":178.0, "partner":"8dtg" @@ -613648,6 +616178,10 @@ "sim":178.0, "partner":"8dti" }, + { + "sim":178.0, + "partner":"8dtf" + }, { "sim":164.0, "partner":"8ur5" @@ -613694,23 +616228,23 @@ }, { "sim":139.0, - "partner":"7ep7" + "partner":"4g2v" }, { "sim":139.0, - "partner":"4g2v" + "partner":"7ep7" }, { "sim":138.0, - "partner":"8a5y" + "partner":"8a3t" }, { "sim":138.0, - "partner":"8a3t" + "partner":"8a61" }, { "sim":138.0, - "partner":"8a61" + "partner":"8a5y" }, { "sim":136.0, @@ -613724,10 +616258,6 @@ "sim":131.0, "partner":"6xt9" }, - { - "sim":130.0, - "partner":"4rg6" - }, { "sim":130.0, "partner":"4rg7" @@ -613738,11 +616268,7 @@ }, { "sim":130.0, - "partner":"5lcw" - }, - { - "sim":130.0, - "partner":"6q6g" + "partner":"4rg6" }, { "sim":130.0, @@ -613766,16 +616292,12 @@ }, { "sim":130.0, - "partner":"8pkp" + "partner":"6tlj" }, { "sim":130.0, "partner":"5l9u" }, - { - "sim":130.0, - "partner":"6tlj" - }, { "sim":130.0, "partner":"6q6h" @@ -613788,6 +616310,10 @@ "sim":130.0, "partner":"5a31" }, + { + "sim":130.0, + "partner":"8pkp" + }, { "sim":130.0, "partner":"5g05" @@ -613800,25 +616326,33 @@ "sim":130.0, "partner":"4ui9" }, + { + "sim":130.0, + "partner":"6q6g" + }, { "sim":130.0, "partner":"8tau" }, + { + "sim":130.0, + "partner":"5lcw" + }, { "sim":125.0, - "partner":"6voa" + "partner":"6vbu" }, { "sim":125.0, - "partner":"6vnw" + "partner":"6vbv" }, { "sim":125.0, - "partner":"6vbu" + "partner":"6voa" }, { "sim":125.0, - "partner":"6vbv" + "partner":"6vnw" }, { "sim":122.0, @@ -613844,22 +616378,6 @@ "sim":107.0, "partner":"6tka" }, - { - "sim":106.0, - "partner":"4xif" - }, - { - "sim":106.0, - "partner":"8fe7" - }, - { - "sim":106.0, - "partner":"4gyw" - }, - { - "sim":106.0, - "partner":"5vif" - }, { "sim":106.0, "partner":"4xi9" @@ -613900,6 +616418,10 @@ "sim":106.0, "partner":"5c1d" }, + { + "sim":106.0, + "partner":"6ma1" + }, { "sim":106.0, "partner":"3pe4" @@ -613922,15 +616444,15 @@ }, { "sim":106.0, - "partner":"6ma1" + "partner":"6ma2" }, { "sim":106.0, - "partner":"4n3c" + "partner":"8fe6" }, { "sim":106.0, - "partner":"6ma2" + "partner":"4n3c" }, { "sim":106.0, @@ -613938,7 +616460,7 @@ }, { "sim":106.0, - "partner":"8fe6" + "partner":"8fuf" }, { "sim":106.0, @@ -613950,7 +616472,11 @@ }, { "sim":106.0, - "partner":"8fuf" + "partner":"8cm9" + }, + { + "sim":106.0, + "partner":"6ma5" }, { "sim":106.0, @@ -613958,11 +616484,15 @@ }, { "sim":106.0, - "partner":"8cm9" + "partner":"8fe7" }, { "sim":106.0, - "partner":"6ma5" + "partner":"6ibo" + }, + { + "sim":106.0, + "partner":"6q4m" }, { "sim":106.0, @@ -613970,11 +616500,15 @@ }, { "sim":106.0, - "partner":"6ibo" + "partner":"4xif" }, { "sim":106.0, - "partner":"6q4m" + "partner":"4gyw" + }, + { + "sim":106.0, + "partner":"5vif" }, { "sim":105.0, @@ -614032,10 +616566,6 @@ "sim":87.0, "partner":"2c0m" }, - { - "sim":87.0, - "partner":"4kyo" - }, { "sim":87.0, "partner":"3r9a" @@ -614048,6 +616578,10 @@ "sim":87.0, "partner":"4kxk" }, + { + "sim":87.0, + "partner":"4kyo" + }, { "sim":87.0, "partner":"1fch" @@ -614254,11 +616788,11 @@ }, { "sim":70.0, - "partner":"5w5i" + "partner":"5w5h" }, { "sim":70.0, - "partner":"5w5h" + "partner":"5w5i" }, { "sim":69.0, @@ -614322,11 +616856,11 @@ }, { "sim":59.0, - "partner":"7qws" + "partner":"6t59" }, { "sim":59.0, - "partner":"6t59" + "partner":"7qws" }, { "sim":59.0, @@ -614382,11 +616916,11 @@ }, { "sim":58.0, - "partner":"4i9e" + "partner":"3ulq" }, { "sim":58.0, - "partner":"3ulq" + "partner":"4i9e" }, { "sim":57.0, @@ -614506,11 +617040,11 @@ }, { "sim":55.0, - "partner":"8hmc" + "partner":"8hmd" }, { "sim":55.0, - "partner":"8hmd" + "partner":"8hmc" }, { "sim":54.0, @@ -614574,11 +617108,11 @@ }, { "sim":52.0, - "partner":"6fdp" + "partner":"6fdt" }, { "sim":52.0, - "partner":"6fdt" + "partner":"6fdp" }, { "sim":52.0, @@ -614624,7 +617158,7 @@ ], "seq_max_sim_designed":{ "sim":622.0, - "partner":"8bu0" + "partner":"8ckr" }, "seq_max_sim_natural":{ "sim":233.0, @@ -614771,89 +617305,89 @@ ], "subtitle":"Solution nmr structure of 8-residue rosetta-designed cyclic peptide d8.31 in d6-dmso with cis\/trans switching (b-ct conformation)", "tags":[ - "switch peptides", - "cis\/trans", + "de novo design", "non natural amino acids", "de novo protein", - "cyclic peptide", - "de novo design", - "membrane permeability" + "switch peptides", + "membrane permeability", + "cis\/trans", + "cyclic peptide" ], "keywords":[ - "predicted", - "35", - "accuracy", - "containing", - "control", - "structural", - "generation", - "designs", + "membranes", + "designed", + "made", + "permeable", + "alternative", "robustly", - "amide", - "engaged", - "membrane", + "orally", "models", + "generation", + "coupled", + "design", + "structural", + "exposed", + "show", + "principles", + "experimental", + "structures", + "therapeutics", + "cross", + "experimentally", + "amide", + "contribute", + "apparent", + "determined", + "residue", "groups", - "membranes", - "use", - "systematically", - "close", - "wide", "noncanonical", - "experimental", - "nh", - "1", - "permeable", - "designed", - "29", - "orally", - "bioavailability", - "peptides", - "macrocycle", - "84", - "10", "bioavailable", - "range", - "fully", - "experimentally", - "modifications", + "control", + "interactions", "state", - "determined", - "cross", - "made", - "ability", - "hydrogen", - "show", - "design", - "bonding", - "apparent", - "characterization", "macrocycles", - "next", - "structures", - "interactions", - "residue", + "membrane", + "wide", + "modifications", + "macrocycle", "lipid", - "therapeutics", + "achieved", + "internal", + "fully", + "accuracy", + "characterization", + "size", + "next", + "close", + "use", "backbone", - "ensuring", + "permeability", + "29", + "1", + "ability", "high", + "bioavailability", + "hydrogen", + "predicted", "favored", - "size", - "184", - "computational", - "permeability", - "principles", - "achieved", "greater", - "coupled", + "engaged", + "peptides", + "range", + "designs", + "10", "oral", - "alternative", - "internal", - "exposed", - "contribute", + "containing", + "computational", + "ensuring", + "35", + "nh", + "systematically", "isoenergetic", - "investigate" + "investigate", + "184", + "84", + "bonding" ], "release_date":"2022-09-14", "publication":"\"Accurate de novo design of membrane-traversing macrocycles\", Cell, 185, 3520-3532.e26", @@ -615040,89 +617574,89 @@ ], "subtitle":"Solution nmr structure of 8-residue rosetta-designed cyclic peptide d8.21 in 50% d6-dmso and 50% water with cis\/trans switching (cc conformation, 50%)", "tags":[ - "switch peptides", - "cis\/trans", + "de novo design", "non natural amino acids", "de novo protein", - "cyclic peptide", - "de novo design", - "membrane permeability" + "switch peptides", + "membrane permeability", + "cis\/trans", + "cyclic peptide" ], "keywords":[ - "predicted", - "35", - "accuracy", - "containing", - "control", - "structural", - "generation", - "designs", + "membranes", + "designed", + "made", + "permeable", + "alternative", "robustly", - "amide", - "engaged", - "membrane", + "orally", "models", + "generation", + "coupled", + "design", + "structural", + "exposed", + "show", + "principles", + "experimental", + "structures", + "therapeutics", + "cross", + "experimentally", + "amide", + "contribute", + "apparent", + "determined", + "residue", "groups", - "membranes", - "use", - "systematically", - "close", - "wide", "noncanonical", - "experimental", - "nh", - "1", - "permeable", - "designed", - "29", - "orally", - "bioavailability", - "peptides", - "macrocycle", - "84", - "10", "bioavailable", - "range", - "fully", - "experimentally", - "modifications", + "control", + "interactions", "state", - "determined", - "cross", - "made", - "ability", - "hydrogen", - "show", - "design", - "bonding", - "apparent", - "characterization", "macrocycles", - "next", - "structures", - "interactions", - "residue", + "membrane", + "wide", + "modifications", + "macrocycle", "lipid", - "therapeutics", + "achieved", + "internal", + "fully", + "accuracy", + "characterization", + "size", + "next", + "close", + "use", "backbone", - "ensuring", + "permeability", + "29", + "1", + "ability", "high", + "bioavailability", + "hydrogen", + "predicted", "favored", - "size", - "184", - "computational", - "permeability", - "principles", - "achieved", "greater", - "coupled", + "engaged", + "peptides", + "range", + "designs", + "10", "oral", - "alternative", - "internal", - "exposed", - "contribute", + "containing", + "computational", + "ensuring", + "35", + "nh", + "systematically", "isoenergetic", - "investigate" + "investigate", + "184", + "84", + "bonding" ], "release_date":"2022-09-14", "publication":"\"Accurate de novo design of membrane-traversing macrocycles\", Cell, 185, 3520-3532.e26", @@ -615337,104 +617871,104 @@ ], "subtitle":"Accurate computational design of genetically encoded 3d protein crystals", "tags":[ - "3d protein crystals", - "genetically encoded", "de novo protein", - "de novo design" + "3d protein crystals", + "de novo design", + "genetically encoded" ], "keywords":[ + "unpredictable", "largely", - "oligomers", - "architecture", - "systematically", - "challenge", - "designed", - "lattice", - "dimensions", + "engineering", + "role", + "structural", + "number", + "outstanding", + "information", + "group", + "three", "mixing", - "provide", - "unpredictable", + "degrees", + "protein", + "across", + "general", "purified", "crystal", - "extremely", - "sequences", - "interactions", - "designing", - "primary", - "porous", + "stable", + "100", + "corresponding", + "encoded", + "enables", + "engineered", + "nearly", + "overall", + "biological", + "specific", + "prespecified", "contacts", + "extremely", + "approach", "develop", - "interfaces", - "general", - "architectures", - "models", - "redesigned", - "cell", - "enables", + "packing", "process", - "outstanding", - "number", - "remains", + "accuracy", + "architecture", "highly", - "materials", - "structures", - "upon", - "empirical", - "atomic", + "freedom", + "computational", "pairs", - "three", - "hierarchically", - "corresponding", - "assembly", - "biology", - "nearly", - "role", - "preferences", + "designing", + "symmetry", + "design", + "individually", "\u00b5m", + "redesigned", + "atomic", + "biology", + "empirical", + "assembly", "platform", + "porous", + "preferences", + "precisely", + "cell", + "architectures", + "constrains", + "understood", + "spontaneously", + "primary", + "upon", + "system", + "retaining", + "crystals", + "identical", + "materials", + "hierarchically", + "designed", + "central", + "models", + "dimensions", + "poorly", + "sequences", + "space", + "interfaces", + "structures", + "oligomers", + "remains", "crystallization", - "plays", + "provide", "powerful", - "100", - "group", - "programming", - "freedom", - "information", "closely", - "specific", - "engineering", - "constrains", + "interactions", + "plays", + "programming", "unit", - "design", - "across", - "symmetry", + "lattice", "high", - "prespecified", - "encoded", - "biological", - "retaining", - "individually", - "packing", - "structural", - "accuracy", - "poorly", - "overall", "despite", - "approach", - "stable", - "engineered", - "understood", - "precisely", - "system", "arrangements", - "central", - "spontaneously", - "protein", - "degrees", - "identical", - "space", - "computational", - "crystals" + "challenge", + "systematically" ], "release_date":"2023-11-01", "publication":"\"Accurate computational design of three-dimensional protein crystals\", Nat Mater, 22, 1556-1563", @@ -615491,11 +618025,11 @@ }, { "sim":99.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":99.0, - "partner":"8cqq" + "partner":"8cqp" }, { "sim":99.0, @@ -615503,27 +618037,27 @@ }, { "sim":99.0, - "partner":"8chy" + "partner":"8cmq" }, { "sim":99.0, - "partner":"8cmq" + "partner":"8bu0" }, { "sim":99.0, - "partner":"8ckr" + "partner":"8cp8" }, { "sim":99.0, - "partner":"8cig" + "partner":"8cqq" }, { "sim":99.0, - "partner":"8cqp" + "partner":"8chy" }, { "sim":99.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":98.0, @@ -615563,19 +618097,19 @@ }, { "sim":76.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":76.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":364.0, - "partner":"9dnd" + "partner":"9dne" }, { "sim":364.0, - "partner":"9dne" + "partner":"9dnd" }, { "sim":313.0, @@ -615583,154 +618117,6 @@ } ], "seq_thr_sim_natural":[ - { - "sim":383.0, - "partner":"1vlw" - }, - { - "sim":378.0, - "partner":"8e01" - }, - { - "sim":374.0, - "partner":"1wa3" - }, - { - "sim":368.0, - "partner":"5kp9" - }, - { - "sim":367.0, - "partner":"8a8n" - }, - { - "sim":363.0, - "partner":"7b3y" - }, - { - "sim":361.0, - "partner":"8ed3" - }, - { - "sim":344.0, - "partner":"8ejh" - }, - { - "sim":344.0, - "partner":"8ejd" - }, - { - "sim":344.0, - "partner":"8eji" - }, - { - "sim":344.0, - "partner":"8ejf" - }, - { - "sim":344.0, - "partner":"7sgd" - }, - { - "sim":344.0, - "partner":"7sge" - }, - { - "sim":344.0, - "partner":"7sgf" - }, - { - "sim":344.0, - "partner":"6p6f" - }, - { - "sim":109.0, - "partner":"8di1" - }, - { - "sim":105.0, - "partner":"3vcr" - }, - { - "sim":104.0, - "partner":"2yw3" - }, - { - "sim":104.0, - "partner":"2yw4" - }, - { - "sim":104.0, - "partner":"6ovi" - }, - { - "sim":102.0, - "partner":"4e38" - }, - { - "sim":98.0, - "partner":"2v81" - }, - { - "sim":98.0, - "partner":"2v82" - }, - { - "sim":98.0, - "partner":"4bk9" - }, - { - "sim":98.0, - "partner":"4qcc" - }, - { - "sim":92.0, - "partner":"5im5" - }, - { - "sim":89.0, - "partner":"1eun" - }, - { - "sim":89.0, - "partner":"1eua" - }, - { - "sim":89.0, - "partner":"1fq0" - }, - { - "sim":89.0, - "partner":"1vhc" - }, - { - "sim":88.0, - "partner":"1wau" - }, - { - "sim":87.0, - "partner":"1wbh" - }, - { - "sim":87.0, - "partner":"2c0a" - }, - { - "sim":86.0, - "partner":"1mxs" - }, - { - "sim":85.0, - "partner":"5xse" - }, - { - "sim":85.0, - "partner":"5xsf" - }, - { - "sim":85.0, - "partner":"1fwr" - }, { "sim":99.0, "partner":"7obi" @@ -615763,10 +618149,6 @@ "sim":70.0, "partner":"7y4i" }, - { - "sim":70.0, - "partner":"8dtf" - }, { "sim":70.0, "partner":"8dtg" @@ -615780,8 +618162,8 @@ "partner":"8dti" }, { - "sim":64.0, - "partner":"4rg6" + "sim":70.0, + "partner":"8dtf" }, { "sim":64.0, @@ -615793,11 +618175,7 @@ }, { "sim":64.0, - "partner":"5lcw" - }, - { - "sim":64.0, - "partner":"6q6g" + "partner":"4rg6" }, { "sim":64.0, @@ -615821,16 +618199,12 @@ }, { "sim":64.0, - "partner":"8pkp" + "partner":"6tlj" }, { "sim":64.0, "partner":"5l9u" }, - { - "sim":64.0, - "partner":"6tlj" - }, { "sim":64.0, "partner":"6q6h" @@ -615843,6 +618217,10 @@ "sim":64.0, "partner":"5a31" }, + { + "sim":64.0, + "partner":"8pkp" + }, { "sim":64.0, "partner":"5g05" @@ -615855,10 +618233,18 @@ "sim":64.0, "partner":"4ui9" }, + { + "sim":64.0, + "partner":"6q6g" + }, { "sim":64.0, "partner":"8tau" }, + { + "sim":64.0, + "partner":"5lcw" + }, { "sim":60.0, "partner":"3cvl" @@ -615887,10 +618273,6 @@ "sim":58.0, "partner":"2c0m" }, - { - "sim":58.0, - "partner":"4kyo" - }, { "sim":58.0, "partner":"3r9a" @@ -615903,6 +618285,10 @@ "sim":58.0, "partner":"4kxk" }, + { + "sim":58.0, + "partner":"4kyo" + }, { "sim":58.0, "partner":"1fch" @@ -615917,19 +618303,19 @@ }, { "sim":56.0, - "partner":"6voa" + "partner":"6vbu" }, { "sim":56.0, - "partner":"6vnw" + "partner":"6vbv" }, { "sim":56.0, - "partner":"6vbu" + "partner":"6voa" }, { "sim":56.0, - "partner":"6vbv" + "partner":"6vnw" }, { "sim":56.0, @@ -615950,6 +618336,154 @@ { "sim":51.0, "partner":"8a3t" + }, + { + "sim":383.0, + "partner":"1vlw" + }, + { + "sim":378.0, + "partner":"8e01" + }, + { + "sim":374.0, + "partner":"1wa3" + }, + { + "sim":368.0, + "partner":"5kp9" + }, + { + "sim":367.0, + "partner":"8a8n" + }, + { + "sim":363.0, + "partner":"7b3y" + }, + { + "sim":361.0, + "partner":"8ed3" + }, + { + "sim":344.0, + "partner":"8ejd" + }, + { + "sim":344.0, + "partner":"8eji" + }, + { + "sim":344.0, + "partner":"8ejf" + }, + { + "sim":344.0, + "partner":"8ejh" + }, + { + "sim":344.0, + "partner":"7sgd" + }, + { + "sim":344.0, + "partner":"7sge" + }, + { + "sim":344.0, + "partner":"7sgf" + }, + { + "sim":344.0, + "partner":"6p6f" + }, + { + "sim":109.0, + "partner":"8di1" + }, + { + "sim":105.0, + "partner":"3vcr" + }, + { + "sim":104.0, + "partner":"2yw3" + }, + { + "sim":104.0, + "partner":"2yw4" + }, + { + "sim":104.0, + "partner":"6ovi" + }, + { + "sim":102.0, + "partner":"4e38" + }, + { + "sim":98.0, + "partner":"2v81" + }, + { + "sim":98.0, + "partner":"2v82" + }, + { + "sim":98.0, + "partner":"4bk9" + }, + { + "sim":98.0, + "partner":"4qcc" + }, + { + "sim":92.0, + "partner":"5im5" + }, + { + "sim":89.0, + "partner":"1eun" + }, + { + "sim":89.0, + "partner":"1eua" + }, + { + "sim":89.0, + "partner":"1fq0" + }, + { + "sim":89.0, + "partner":"1vhc" + }, + { + "sim":88.0, + "partner":"1wau" + }, + { + "sim":87.0, + "partner":"1wbh" + }, + { + "sim":87.0, + "partner":"2c0a" + }, + { + "sim":86.0, + "partner":"1mxs" + }, + { + "sim":85.0, + "partner":"5xse" + }, + { + "sim":85.0, + "partner":"5xsf" + }, + { + "sim":85.0, + "partner":"1fwr" } ], "struct_thr_sim_designed":[ @@ -616153,104 +618687,104 @@ ], "subtitle":"Accurate computational design of genetically encoded 3d protein crystals", "tags":[ - "3d protein crystals", - "genetically encoded", "de novo protein", - "de novo design" + "3d protein crystals", + "de novo design", + "genetically encoded" ], "keywords":[ + "unpredictable", "largely", - "oligomers", - "architecture", - "systematically", - "challenge", - "designed", - "lattice", - "dimensions", + "engineering", + "role", + "structural", + "number", + "outstanding", + "information", + "group", + "three", "mixing", - "provide", - "unpredictable", + "degrees", + "protein", + "across", + "general", "purified", "crystal", - "extremely", - "sequences", - "interactions", - "designing", - "primary", - "porous", + "stable", + "100", + "corresponding", + "encoded", + "enables", + "engineered", + "nearly", + "overall", + "biological", + "specific", + "prespecified", "contacts", + "extremely", + "approach", "develop", - "interfaces", - "general", - "architectures", - "models", - "redesigned", - "cell", - "enables", + "packing", "process", - "outstanding", - "number", - "remains", + "accuracy", + "architecture", "highly", - "materials", - "structures", - "upon", - "empirical", - "atomic", + "freedom", + "computational", "pairs", - "three", - "hierarchically", - "corresponding", - "assembly", - "biology", - "nearly", - "role", - "preferences", + "designing", + "symmetry", + "design", + "individually", "\u00b5m", + "redesigned", + "atomic", + "biology", + "empirical", + "assembly", "platform", + "porous", + "preferences", + "precisely", + "cell", + "architectures", + "constrains", + "understood", + "spontaneously", + "primary", + "upon", + "system", + "retaining", + "crystals", + "identical", + "materials", + "hierarchically", + "designed", + "central", + "models", + "dimensions", + "poorly", + "sequences", + "space", + "interfaces", + "structures", + "oligomers", + "remains", "crystallization", - "plays", + "provide", "powerful", - "100", - "group", - "programming", - "freedom", - "information", "closely", - "specific", - "engineering", - "constrains", + "interactions", + "plays", + "programming", "unit", - "design", - "across", - "symmetry", + "lattice", "high", - "prespecified", - "encoded", - "biological", - "retaining", - "individually", - "packing", - "structural", - "accuracy", - "poorly", - "overall", "despite", - "approach", - "stable", - "engineered", - "understood", - "precisely", - "system", "arrangements", - "central", - "spontaneously", - "protein", - "degrees", - "identical", - "space", - "computational", - "crystals" + "challenge", + "systematically" ], "release_date":"2023-11-01", "publication":"\"Accurate computational design of three-dimensional protein crystals\", Nat Mater, 22, 1556-1563", @@ -616281,14 +618815,14 @@ "previous_design":"8cus", "next_design":"8cuu", "seq_thr_sim_designed":[ - { - "sim":423.0, - "partner":"8cwz" - }, { "sim":436.0, "partner":"8cus" }, + { + "sim":423.0, + "partner":"8cwz" + }, { "sim":411.0, "partner":"8far" @@ -616307,11 +618841,11 @@ }, { "sim":99.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":99.0, - "partner":"8cqq" + "partner":"8cqp" }, { "sim":99.0, @@ -616319,27 +618853,27 @@ }, { "sim":99.0, - "partner":"8chy" + "partner":"8cmq" }, { "sim":99.0, - "partner":"8cmq" + "partner":"8bu0" }, { "sim":99.0, - "partner":"8ckr" + "partner":"8cp8" }, { "sim":99.0, - "partner":"8cig" + "partner":"8cqq" }, { "sim":99.0, - "partner":"8cqp" + "partner":"8chy" }, { "sim":99.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":98.0, @@ -616379,19 +618913,19 @@ }, { "sim":76.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":76.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":364.0, - "partner":"9dnd" + "partner":"9dne" }, { "sim":364.0, - "partner":"9dne" + "partner":"9dnd" }, { "sim":313.0, @@ -616431,10 +618965,6 @@ "sim":70.0, "partner":"7y4i" }, - { - "sim":70.0, - "partner":"8dtf" - }, { "sim":70.0, "partner":"8dtg" @@ -616448,8 +618978,8 @@ "partner":"8dti" }, { - "sim":64.0, - "partner":"4rg6" + "sim":70.0, + "partner":"8dtf" }, { "sim":64.0, @@ -616461,11 +618991,7 @@ }, { "sim":64.0, - "partner":"5lcw" - }, - { - "sim":64.0, - "partner":"6q6g" + "partner":"4rg6" }, { "sim":64.0, @@ -616489,16 +619015,12 @@ }, { "sim":64.0, - "partner":"8pkp" + "partner":"6tlj" }, { "sim":64.0, "partner":"5l9u" }, - { - "sim":64.0, - "partner":"6tlj" - }, { "sim":64.0, "partner":"6q6h" @@ -616511,6 +619033,10 @@ "sim":64.0, "partner":"5a31" }, + { + "sim":64.0, + "partner":"8pkp" + }, { "sim":64.0, "partner":"5g05" @@ -616523,10 +619049,18 @@ "sim":64.0, "partner":"4ui9" }, + { + "sim":64.0, + "partner":"6q6g" + }, { "sim":64.0, "partner":"8tau" }, + { + "sim":64.0, + "partner":"5lcw" + }, { "sim":60.0, "partner":"3cvl" @@ -616555,10 +619089,6 @@ "sim":58.0, "partner":"2c0m" }, - { - "sim":58.0, - "partner":"4kyo" - }, { "sim":58.0, "partner":"3r9a" @@ -616571,6 +619101,10 @@ "sim":58.0, "partner":"4kxk" }, + { + "sim":58.0, + "partner":"4kyo" + }, { "sim":58.0, "partner":"1fch" @@ -616585,19 +619119,19 @@ }, { "sim":56.0, - "partner":"6voa" + "partner":"6vbu" }, { "sim":56.0, - "partner":"6vnw" + "partner":"6vbv" }, { "sim":56.0, - "partner":"6vbu" + "partner":"6voa" }, { "sim":56.0, - "partner":"6vbv" + "partner":"6vnw" }, { "sim":56.0, @@ -616647,10 +619181,6 @@ "sim":361.0, "partner":"8ed3" }, - { - "sim":344.0, - "partner":"8ejh" - }, { "sim":344.0, "partner":"8ejd" @@ -616663,6 +619193,10 @@ "sim":344.0, "partner":"8ejf" }, + { + "sim":344.0, + "partner":"8ejh" + }, { "sim":344.0, "partner":"7sgd" @@ -616973,104 +619507,104 @@ ], "subtitle":"Accurate computational design of genetically encoded 3d protein crystals", "tags":[ - "3d protein crystals", - "genetically encoded", "de novo protein", - "de novo design" + "3d protein crystals", + "de novo design", + "genetically encoded" ], "keywords":[ + "unpredictable", "largely", - "oligomers", - "architecture", - "systematically", - "challenge", - "designed", - "lattice", - "dimensions", + "engineering", + "role", + "structural", + "number", + "outstanding", + "information", + "group", + "three", "mixing", - "provide", - "unpredictable", + "degrees", + "protein", + "across", + "general", "purified", "crystal", - "extremely", - "sequences", - "interactions", - "designing", - "primary", - "porous", + "stable", + "100", + "corresponding", + "encoded", + "enables", + "engineered", + "nearly", + "overall", + "biological", + "specific", + "prespecified", "contacts", + "extremely", + "approach", "develop", - "interfaces", - "general", - "architectures", - "models", - "redesigned", - "cell", - "enables", + "packing", "process", - "outstanding", - "number", - "remains", + "accuracy", + "architecture", "highly", - "materials", - "structures", - "upon", - "empirical", - "atomic", + "freedom", + "computational", "pairs", - "three", - "hierarchically", - "corresponding", - "assembly", - "biology", - "nearly", - "role", - "preferences", + "designing", + "symmetry", + "design", + "individually", "\u00b5m", + "redesigned", + "atomic", + "biology", + "empirical", + "assembly", "platform", + "porous", + "preferences", + "precisely", + "cell", + "architectures", + "constrains", + "understood", + "spontaneously", + "primary", + "upon", + "system", + "retaining", + "crystals", + "identical", + "materials", + "hierarchically", + "designed", + "central", + "models", + "dimensions", + "poorly", + "sequences", + "space", + "interfaces", + "structures", + "oligomers", + "remains", "crystallization", - "plays", + "provide", "powerful", - "100", - "group", - "programming", - "freedom", - "information", "closely", - "specific", - "engineering", - "constrains", + "interactions", + "plays", + "programming", "unit", - "design", - "across", - "symmetry", + "lattice", "high", - "prespecified", - "encoded", - "biological", - "retaining", - "individually", - "packing", - "structural", - "accuracy", - "poorly", - "overall", "despite", - "approach", - "stable", - "engineered", - "understood", - "precisely", - "system", "arrangements", - "central", - "spontaneously", - "protein", - "degrees", - "identical", - "space", - "computational", - "crystals" + "challenge", + "systematically" ], "release_date":"2023-11-01", "publication":"\"Accurate computational design of three-dimensional protein crystals\", Nat Mater, 22, 1556-1563", @@ -617103,11 +619637,11 @@ "seq_thr_sim_designed":[ { "sim":376.0, - "partner":"8cuw" + "partner":"8cuv" }, { "sim":376.0, - "partner":"8cuv" + "partner":"8cuw" }, { "sim":238.0, @@ -617119,6 +619653,74 @@ "sim":353.0, "partner":"4nwo" }, + { + "sim":237.0, + "partner":"4zk7" + }, + { + "sim":220.0, + "partner":"7l85" + }, + { + "sim":213.0, + "partner":"1ufy" + }, + { + "sim":213.0, + "partner":"1ode" + }, + { + "sim":212.0, + "partner":"1ui9" + }, + { + "sim":103.0, + "partner":"7r4b" + }, + { + "sim":102.0, + "partner":"1xho" + }, + { + "sim":98.0, + "partner":"2chs" + }, + { + "sim":98.0, + "partner":"1com" + }, + { + "sim":98.0, + "partner":"2cht" + }, + { + "sim":98.0, + "partner":"3zo8" + }, + { + "sim":98.0, + "partner":"1dbf" + }, + { + "sim":96.0, + "partner":"1fnj" + }, + { + "sim":95.0, + "partner":"3zp4" + }, + { + "sim":95.0, + "partner":"3zp7" + }, + { + "sim":95.0, + "partner":"3zop" + }, + { + "sim":95.0, + "partner":"1fnk" + }, { "sim":324.0, "partner":"2f7w" @@ -617131,10 +619733,6 @@ "sim":323.0, "partner":"3k6a" }, - { - "sim":228.0, - "partner":"3mcj" - }, { "sim":228.0, "partner":"2pbq" @@ -617147,6 +619745,10 @@ "sim":228.0, "partner":"3mci" }, + { + "sim":228.0, + "partner":"3mcj" + }, { "sim":217.0, "partner":"4xcw" @@ -617181,15 +619783,15 @@ }, { "sim":116.0, - "partner":"1uuy" + "partner":"1o8n" }, { "sim":116.0, - "partner":"1o8n" + "partner":"1o8q" }, { "sim":116.0, - "partner":"1o8q" + "partner":"1uuy" }, { "sim":115.0, @@ -617209,11 +619811,11 @@ }, { "sim":88.0, - "partner":"3oi9" + "partner":"3pzy" }, { "sim":88.0, - "partner":"3pzy" + "partner":"3oi9" }, { "sim":72.0, @@ -617246,74 +619848,6 @@ { "sim":53.0, "partner":"2g2c" - }, - { - "sim":237.0, - "partner":"4zk7" - }, - { - "sim":220.0, - "partner":"7l85" - }, - { - "sim":213.0, - "partner":"1ode" - }, - { - "sim":213.0, - "partner":"1ufy" - }, - { - "sim":212.0, - "partner":"1ui9" - }, - { - "sim":103.0, - "partner":"7r4b" - }, - { - "sim":102.0, - "partner":"1xho" - }, - { - "sim":98.0, - "partner":"2chs" - }, - { - "sim":98.0, - "partner":"1com" - }, - { - "sim":98.0, - "partner":"2cht" - }, - { - "sim":98.0, - "partner":"3zo8" - }, - { - "sim":98.0, - "partner":"1dbf" - }, - { - "sim":96.0, - "partner":"1fnj" - }, - { - "sim":95.0, - "partner":"3zp4" - }, - { - "sim":95.0, - "partner":"3zp7" - }, - { - "sim":95.0, - "partner":"3zop" - }, - { - "sim":95.0, - "partner":"1fnk" } ], "struct_thr_sim_designed":[ @@ -617331,14 +619865,6 @@ } ], "struct_thr_sim_natural":[ - { - "sim":0.9548000097, - "partner":"1ufy" - }, - { - "sim":0.977699995, - "partner":"4zk7" - }, { "sim":0.9824000001, "partner":"4nwo" @@ -617346,11 +619872,19 @@ { "sim":0.9589999914, "partner":"3k6a" + }, + { + "sim":0.9548000097, + "partner":"1ufy" + }, + { + "sim":0.977699995, + "partner":"4zk7" } ], "seq_max_sim_designed":{ "sim":376.0, - "partner":"8cuw" + "partner":"8cuv" }, "seq_max_sim_natural":{ "sim":353.0, @@ -617525,104 +620059,104 @@ ], "subtitle":"Accurate computational design of genetically encoded 3d protein crystals", "tags":[ - "3d protein crystals", - "genetically encoded", "de novo protein", - "de novo design" + "3d protein crystals", + "de novo design", + "genetically encoded" ], "keywords":[ + "unpredictable", "largely", - "oligomers", - "architecture", - "systematically", - "challenge", - "designed", - "lattice", - "dimensions", + "engineering", + "role", + "structural", + "number", + "outstanding", + "information", + "group", + "three", "mixing", - "provide", - "unpredictable", + "degrees", + "protein", + "across", + "general", "purified", "crystal", - "extremely", - "sequences", - "interactions", - "designing", - "primary", - "porous", + "stable", + "100", + "corresponding", + "encoded", + "enables", + "engineered", + "nearly", + "overall", + "biological", + "specific", + "prespecified", "contacts", + "extremely", + "approach", "develop", - "interfaces", - "general", - "architectures", - "models", - "redesigned", - "cell", - "enables", + "packing", "process", - "outstanding", - "number", - "remains", + "accuracy", + "architecture", "highly", - "materials", - "structures", - "upon", - "empirical", - "atomic", + "freedom", + "computational", "pairs", - "three", - "hierarchically", - "corresponding", - "assembly", - "biology", - "nearly", - "role", - "preferences", + "designing", + "symmetry", + "design", + "individually", "\u00b5m", + "redesigned", + "atomic", + "biology", + "empirical", + "assembly", "platform", + "porous", + "preferences", + "precisely", + "cell", + "architectures", + "constrains", + "understood", + "spontaneously", + "primary", + "upon", + "system", + "retaining", + "crystals", + "identical", + "materials", + "hierarchically", + "designed", + "central", + "models", + "dimensions", + "poorly", + "sequences", + "space", + "interfaces", + "structures", + "oligomers", + "remains", "crystallization", - "plays", + "provide", "powerful", - "100", - "group", - "programming", - "freedom", - "information", "closely", - "specific", - "engineering", - "constrains", + "interactions", + "plays", + "programming", "unit", - "design", - "across", - "symmetry", + "lattice", "high", - "prespecified", - "encoded", - "biological", - "retaining", - "individually", - "packing", - "structural", - "accuracy", - "poorly", - "overall", "despite", - "approach", - "stable", - "engineered", - "understood", - "precisely", - "system", "arrangements", - "central", - "spontaneously", - "protein", - "degrees", - "identical", - "space", - "computational", - "crystals" + "challenge", + "systematically" ], "release_date":"2023-11-01", "publication":"\"Accurate computational design of three-dimensional protein crystals\", Nat Mater, 22, 1556-1563", @@ -617671,74 +620205,6 @@ "sim":350.0, "partner":"4nwo" }, - { - "sim":237.0, - "partner":"4zk7" - }, - { - "sim":220.0, - "partner":"7l85" - }, - { - "sim":213.0, - "partner":"1ode" - }, - { - "sim":213.0, - "partner":"1ufy" - }, - { - "sim":212.0, - "partner":"1ui9" - }, - { - "sim":103.0, - "partner":"7r4b" - }, - { - "sim":102.0, - "partner":"1xho" - }, - { - "sim":98.0, - "partner":"2chs" - }, - { - "sim":98.0, - "partner":"1com" - }, - { - "sim":98.0, - "partner":"2cht" - }, - { - "sim":98.0, - "partner":"3zo8" - }, - { - "sim":98.0, - "partner":"1dbf" - }, - { - "sim":96.0, - "partner":"1fnj" - }, - { - "sim":95.0, - "partner":"3zp4" - }, - { - "sim":95.0, - "partner":"3zp7" - }, - { - "sim":95.0, - "partner":"3zop" - }, - { - "sim":95.0, - "partner":"1fnk" - }, { "sim":322.0, "partner":"2f7w" @@ -617751,10 +620217,6 @@ "sim":321.0, "partner":"3k6a" }, - { - "sim":229.0, - "partner":"3mcj" - }, { "sim":229.0, "partner":"2pbq" @@ -617767,6 +620229,10 @@ "sim":229.0, "partner":"3mci" }, + { + "sim":229.0, + "partner":"3mcj" + }, { "sim":218.0, "partner":"4xcw" @@ -617797,11 +620263,11 @@ }, { "sim":116.0, - "partner":"1uuy" + "partner":"1o8q" }, { "sim":116.0, - "partner":"1o8q" + "partner":"1uuy" }, { "sim":115.0, @@ -617821,11 +620287,11 @@ }, { "sim":88.0, - "partner":"3oi9" + "partner":"3pzy" }, { "sim":88.0, - "partner":"3pzy" + "partner":"3oi9" }, { "sim":87.0, @@ -617866,9 +620332,81 @@ { "sim":52.0, "partner":"2g2c" + }, + { + "sim":237.0, + "partner":"4zk7" + }, + { + "sim":220.0, + "partner":"7l85" + }, + { + "sim":213.0, + "partner":"1ufy" + }, + { + "sim":213.0, + "partner":"1ode" + }, + { + "sim":212.0, + "partner":"1ui9" + }, + { + "sim":103.0, + "partner":"7r4b" + }, + { + "sim":102.0, + "partner":"1xho" + }, + { + "sim":98.0, + "partner":"2chs" + }, + { + "sim":98.0, + "partner":"1com" + }, + { + "sim":98.0, + "partner":"2cht" + }, + { + "sim":98.0, + "partner":"3zo8" + }, + { + "sim":98.0, + "partner":"1dbf" + }, + { + "sim":96.0, + "partner":"1fnj" + }, + { + "sim":95.0, + "partner":"3zp4" + }, + { + "sim":95.0, + "partner":"3zp7" + }, + { + "sim":95.0, + "partner":"3zop" + }, + { + "sim":95.0, + "partner":"1fnk" } ], "struct_thr_sim_designed":[ + { + "sim":0.9801999927, + "partner":"8cux" + }, { "sim":0.9815000296, "partner":"8cuu" @@ -617876,21 +620414,9 @@ { "sim":0.9693999887, "partner":"8cuw" - }, - { - "sim":0.9801999927, - "partner":"8cux" } ], "struct_thr_sim_natural":[ - { - "sim":0.9900000095, - "partner":"4nwo" - }, - { - "sim":0.9541000128, - "partner":"3k6a" - }, { "sim":0.9771000147, "partner":"1ufy" @@ -617902,6 +620428,14 @@ { "sim":0.9617000222, "partner":"1ui9" + }, + { + "sim":0.9900000095, + "partner":"4nwo" + }, + { + "sim":0.9541000128, + "partner":"3k6a" } ], "seq_max_sim_designed":{ @@ -618081,104 +620615,104 @@ ], "subtitle":"Accurate computational design of genetically encoded 3d protein crystals", "tags":[ - "3d protein crystals", - "genetically encoded", "de novo protein", - "de novo design" + "3d protein crystals", + "de novo design", + "genetically encoded" ], "keywords":[ + "unpredictable", "largely", - "oligomers", - "architecture", - "systematically", - "challenge", - "designed", - "lattice", - "dimensions", + "engineering", + "role", + "structural", + "number", + "outstanding", + "information", + "group", + "three", "mixing", - "provide", - "unpredictable", + "degrees", + "protein", + "across", + "general", "purified", "crystal", - "extremely", - "sequences", - "interactions", - "designing", - "primary", - "porous", + "stable", + "100", + "corresponding", + "encoded", + "enables", + "engineered", + "nearly", + "overall", + "biological", + "specific", + "prespecified", "contacts", + "extremely", + "approach", "develop", - "interfaces", - "general", - "architectures", - "models", - "redesigned", - "cell", - "enables", + "packing", "process", - "outstanding", - "number", - "remains", + "accuracy", + "architecture", "highly", - "materials", - "structures", - "upon", - "empirical", - "atomic", + "freedom", + "computational", "pairs", - "three", - "hierarchically", - "corresponding", - "assembly", - "biology", - "nearly", - "role", - "preferences", + "designing", + "symmetry", + "design", + "individually", "\u00b5m", + "redesigned", + "atomic", + "biology", + "empirical", + "assembly", "platform", + "porous", + "preferences", + "precisely", + "cell", + "architectures", + "constrains", + "understood", + "spontaneously", + "primary", + "upon", + "system", + "retaining", + "crystals", + "identical", + "materials", + "hierarchically", + "designed", + "central", + "models", + "dimensions", + "poorly", + "sequences", + "space", + "interfaces", + "structures", + "oligomers", + "remains", "crystallization", - "plays", + "provide", "powerful", - "100", - "group", - "programming", - "freedom", - "information", "closely", - "specific", - "engineering", - "constrains", + "interactions", + "plays", + "programming", "unit", - "design", - "across", - "symmetry", + "lattice", "high", - "prespecified", - "encoded", - "biological", - "retaining", - "individually", - "packing", - "structural", - "accuracy", - "poorly", - "overall", "despite", - "approach", - "stable", - "engineered", - "understood", - "precisely", - "system", "arrangements", - "central", - "spontaneously", - "protein", - "degrees", - "identical", - "space", - "computational", - "crystals" + "challenge", + "systematically" ], "release_date":"2023-11-01", "publication":"\"Accurate computational design of three-dimensional protein crystals\", Nat Mater, 22, 1556-1563", @@ -618209,14 +620743,14 @@ "previous_design":"8cuv", "next_design":"8cux", "seq_thr_sim_designed":[ - { - "sim":376.0, - "partner":"8cuu" - }, { "sim":375.0, "partner":"8cuv" }, + { + "sim":376.0, + "partner":"8cuu" + }, { "sim":238.0, "partner":"8cux" @@ -618237,11 +620771,11 @@ }, { "sim":213.0, - "partner":"1ode" + "partner":"1ufy" }, { "sim":213.0, - "partner":"1ufy" + "partner":"1ode" }, { "sim":212.0, @@ -618307,10 +620841,6 @@ "sim":323.0, "partner":"3k6a" }, - { - "sim":228.0, - "partner":"3mcj" - }, { "sim":228.0, "partner":"2pbq" @@ -618323,6 +620853,10 @@ "sim":228.0, "partner":"3mci" }, + { + "sim":228.0, + "partner":"3mcj" + }, { "sim":217.0, "partner":"4xcw" @@ -618349,11 +620883,11 @@ }, { "sim":117.0, - "partner":"1uuy" + "partner":"1o8q" }, { "sim":117.0, - "partner":"1o8q" + "partner":"1uuy" }, { "sim":117.0, @@ -618381,11 +620915,11 @@ }, { "sim":88.0, - "partner":"3oi9" + "partner":"3pzy" }, { "sim":88.0, - "partner":"3pzy" + "partner":"3oi9" }, { "sim":87.0, @@ -618439,13 +620973,13 @@ } ], "struct_thr_sim_natural":[ - { - "sim":0.9636999965, - "partner":"4zk7" - }, { "sim":0.9610999823, "partner":"4nwo" + }, + { + "sim":0.9636999965, + "partner":"4zk7" } ], "seq_max_sim_designed":{ @@ -618617,104 +621151,104 @@ ], "subtitle":"Accurate computational design of genetically encoded 3d protein crystals", "tags":[ - "3d protein crystals", - "genetically encoded", "de novo protein", - "de novo design" + "3d protein crystals", + "de novo design", + "genetically encoded" ], "keywords":[ + "unpredictable", "largely", - "oligomers", - "architecture", - "systematically", - "challenge", - "designed", - "lattice", - "dimensions", + "engineering", + "role", + "structural", + "number", + "outstanding", + "information", + "group", + "three", "mixing", - "provide", - "unpredictable", + "degrees", + "protein", + "across", + "general", "purified", "crystal", - "extremely", - "sequences", - "interactions", - "designing", - "primary", - "porous", + "stable", + "100", + "corresponding", + "encoded", + "enables", + "engineered", + "nearly", + "overall", + "biological", + "specific", + "prespecified", "contacts", + "extremely", + "approach", "develop", - "interfaces", - "general", - "architectures", - "models", - "redesigned", - "cell", - "enables", + "packing", "process", - "outstanding", - "number", - "remains", + "accuracy", + "architecture", "highly", - "materials", - "structures", - "upon", - "empirical", - "atomic", + "freedom", + "computational", "pairs", - "three", - "hierarchically", - "corresponding", - "assembly", - "biology", - "nearly", - "role", - "preferences", + "designing", + "symmetry", + "design", + "individually", "\u00b5m", + "redesigned", + "atomic", + "biology", + "empirical", + "assembly", "platform", + "porous", + "preferences", + "precisely", + "cell", + "architectures", + "constrains", + "understood", + "spontaneously", + "primary", + "upon", + "system", + "retaining", + "crystals", + "identical", + "materials", + "hierarchically", + "designed", + "central", + "models", + "dimensions", + "poorly", + "sequences", + "space", + "interfaces", + "structures", + "oligomers", + "remains", "crystallization", - "plays", + "provide", "powerful", - "100", - "group", - "programming", - "freedom", - "information", "closely", - "specific", - "engineering", - "constrains", + "interactions", + "plays", + "programming", "unit", - "design", - "across", - "symmetry", + "lattice", "high", - "prespecified", - "encoded", - "biological", - "retaining", - "individually", - "packing", - "structural", - "accuracy", - "poorly", - "overall", "despite", - "approach", - "stable", - "engineered", - "understood", - "precisely", - "system", "arrangements", - "central", - "spontaneously", - "protein", - "degrees", - "identical", - "space", - "computational", - "crystals" + "challenge", + "systematically" ], "release_date":"2023-11-01", "publication":"\"Accurate computational design of three-dimensional protein crystals\", Nat Mater, 22, 1556-1563", @@ -618751,11 +621285,11 @@ }, { "sim":239.0, - "partner":"8cuu" + "partner":"8cuv" }, { "sim":239.0, - "partner":"8cuv" + "partner":"8cuu" } ], "seq_thr_sim_natural":[ @@ -618773,11 +621307,11 @@ }, { "sim":213.0, - "partner":"1ode" + "partner":"1ufy" }, { "sim":213.0, - "partner":"1ufy" + "partner":"1ode" }, { "sim":212.0, @@ -619001,89 +621535,89 @@ ], "subtitle":"Solution nmr structure of 8-residue rosetta-designed cyclic peptide d8.21 in cdcl3 with cis\/trans switching (tc conformation, 53%)", "tags":[ - "switch peptides", - "cis\/trans", + "de novo design", "non natural amino acids", "de novo protein", - "cyclic peptide", - "de novo design", - "membrane permeability" + "switch peptides", + "membrane permeability", + "cis\/trans", + "cyclic peptide" ], "keywords":[ - "predicted", - "35", - "accuracy", - "containing", - "control", - "structural", - "generation", - "designs", + "membranes", + "designed", + "made", + "permeable", + "alternative", "robustly", - "amide", - "engaged", - "membrane", + "orally", "models", + "generation", + "coupled", + "design", + "structural", + "exposed", + "show", + "principles", + "experimental", + "structures", + "therapeutics", + "cross", + "experimentally", + "amide", + "contribute", + "apparent", + "determined", + "residue", "groups", - "membranes", - "use", - "systematically", - "close", - "wide", "noncanonical", - "experimental", - "nh", - "1", - "permeable", - "designed", - "29", - "orally", - "bioavailability", - "peptides", - "macrocycle", - "84", - "10", "bioavailable", - "range", - "fully", - "experimentally", - "modifications", + "control", + "interactions", "state", - "determined", - "cross", - "made", - "ability", - "hydrogen", - "show", - "design", - "bonding", - "apparent", - "characterization", "macrocycles", - "next", - "structures", - "interactions", - "residue", + "membrane", + "wide", + "modifications", + "macrocycle", "lipid", - "therapeutics", + "achieved", + "internal", + "fully", + "accuracy", + "characterization", + "size", + "next", + "close", + "use", "backbone", - "ensuring", + "permeability", + "29", + "1", + "ability", "high", + "bioavailability", + "hydrogen", + "predicted", "favored", - "size", - "184", - "computational", - "permeability", - "principles", - "achieved", "greater", - "coupled", + "engaged", + "peptides", + "range", + "designs", + "10", "oral", - "alternative", - "internal", - "exposed", - "contribute", + "containing", + "computational", + "ensuring", + "35", + "nh", + "systematically", "isoenergetic", - "investigate" + "investigate", + "184", + "84", + "bonding" ], "release_date":"2022-09-14", "publication":"\"Accurate de novo design of membrane-traversing macrocycles\", Cell, 185, 3520-3532.e26", @@ -619298,104 +621832,104 @@ ], "subtitle":"Accurate computational design of genetically encoded 3d protein crystals", "tags":[ - "3d protein crystals", - "genetically encoded", "de novo protein", - "de novo design" + "3d protein crystals", + "de novo design", + "genetically encoded" ], "keywords":[ + "unpredictable", "largely", - "oligomers", - "architecture", - "systematically", - "challenge", - "designed", - "lattice", - "dimensions", + "engineering", + "role", + "structural", + "number", + "outstanding", + "information", + "group", + "three", "mixing", - "provide", - "unpredictable", + "degrees", + "protein", + "across", + "general", "purified", "crystal", - "extremely", - "sequences", - "interactions", - "designing", - "primary", - "porous", + "stable", + "100", + "corresponding", + "encoded", + "enables", + "engineered", + "nearly", + "overall", + "biological", + "specific", + "prespecified", "contacts", + "extremely", + "approach", "develop", - "interfaces", - "general", - "architectures", - "models", - "redesigned", - "cell", - "enables", + "packing", "process", - "outstanding", - "number", - "remains", + "accuracy", + "architecture", "highly", - "materials", - "structures", - "upon", - "empirical", - "atomic", + "freedom", + "computational", "pairs", - "three", - "hierarchically", - "corresponding", - "assembly", - "biology", - "nearly", - "role", - "preferences", + "designing", + "symmetry", + "design", + "individually", "\u00b5m", + "redesigned", + "atomic", + "biology", + "empirical", + "assembly", "platform", + "porous", + "preferences", + "precisely", + "cell", + "architectures", + "constrains", + "understood", + "spontaneously", + "primary", + "upon", + "system", + "retaining", + "crystals", + "identical", + "materials", + "hierarchically", + "designed", + "central", + "models", + "dimensions", + "poorly", + "sequences", + "space", + "interfaces", + "structures", + "oligomers", + "remains", "crystallization", - "plays", + "provide", "powerful", - "100", - "group", - "programming", - "freedom", - "information", "closely", - "specific", - "engineering", - "constrains", + "interactions", + "plays", + "programming", "unit", - "design", - "across", - "symmetry", + "lattice", "high", - "prespecified", - "encoded", - "biological", - "retaining", - "individually", - "packing", - "structural", - "accuracy", - "poorly", - "overall", "despite", - "approach", - "stable", - "engineered", - "understood", - "precisely", - "system", "arrangements", - "central", - "spontaneously", - "protein", - "degrees", - "identical", - "space", - "computational", - "crystals" + "challenge", + "systematically" ], "release_date":"2023-11-01", "publication":"\"Accurate computational design of three-dimensional protein crystals\", Nat Mater, 22, 1556-1563", @@ -619430,6 +621964,14 @@ "sim":768.0, "partner":"8cwy" }, + { + "sim":66.0, + "partner":"5j0k" + }, + { + "sim":66.0, + "partner":"6egc" + }, { "sim":310.0, "partner":"5cwb" @@ -619465,14 +622007,6 @@ { "sim":83.0, "partner":"6msr" - }, - { - "sim":66.0, - "partner":"5j0k" - }, - { - "sim":66.0, - "partner":"6egc" } ], "seq_thr_sim_natural":[ @@ -619683,106 +622217,106 @@ ], "subtitle":"Accurate computational design of genetically encoded 3d protein crystals", "tags":[ + "de novo design", "3d crystals", - "cryoem", - "rosetta", "de novo protein", - "nanocage", - "de novo design" + "rosetta", + "cryoem", + "nanocage" ], "keywords":[ + "unpredictable", "largely", - "oligomers", - "architecture", - "systematically", - "challenge", - "designed", - "lattice", - "dimensions", + "engineering", + "role", + "structural", + "number", + "outstanding", + "information", + "group", + "three", "mixing", - "provide", - "unpredictable", + "degrees", + "protein", + "across", + "general", "purified", "crystal", - "extremely", - "sequences", - "interactions", - "designing", - "primary", - "porous", + "stable", + "100", + "corresponding", + "encoded", + "enables", + "engineered", + "nearly", + "overall", + "biological", + "specific", + "prespecified", "contacts", + "extremely", + "approach", "develop", - "interfaces", - "general", - "architectures", - "models", - "redesigned", - "cell", - "enables", + "packing", "process", - "outstanding", - "number", - "remains", + "accuracy", + "architecture", "highly", - "materials", - "structures", - "upon", - "empirical", - "atomic", + "freedom", + "computational", "pairs", - "three", - "hierarchically", - "corresponding", - "assembly", - "biology", - "nearly", - "role", - "preferences", + "designing", + "symmetry", + "design", + "individually", "\u00b5m", + "redesigned", + "atomic", + "biology", + "empirical", + "assembly", "platform", + "porous", + "preferences", + "precisely", + "cell", + "architectures", + "constrains", + "understood", + "spontaneously", + "primary", + "upon", + "system", + "retaining", + "crystals", + "identical", + "materials", + "hierarchically", + "designed", + "central", + "models", + "dimensions", + "poorly", + "sequences", + "space", + "interfaces", + "structures", + "oligomers", + "remains", "crystallization", - "plays", + "provide", "powerful", - "100", - "group", - "programming", - "freedom", - "information", "closely", - "specific", - "engineering", - "constrains", + "interactions", + "plays", + "programming", "unit", - "design", - "across", - "symmetry", + "lattice", "high", - "prespecified", - "encoded", - "biological", - "retaining", - "individually", - "packing", - "structural", - "accuracy", - "poorly", - "overall", "despite", - "approach", - "stable", - "engineered", - "understood", - "precisely", - "system", "arrangements", - "central", - "spontaneously", - "protein", - "degrees", - "identical", - "space", - "computational", - "crystals" + "challenge", + "systematically" ], "release_date":"2023-11-01", "publication":"\"Accurate computational design of three-dimensional protein crystals\", Nat Mater, 22, 1556-1563", @@ -620074,104 +622608,104 @@ ], "subtitle":"Accurate computational design of genetically encoded 3d protein crystals", "tags":[ - "3d protein crystals", - "genetically encoded", "de novo protein", - "de novo design" + "3d protein crystals", + "de novo design", + "genetically encoded" ], "keywords":[ + "unpredictable", "largely", - "oligomers", - "architecture", - "systematically", - "challenge", - "designed", - "lattice", - "dimensions", + "engineering", + "role", + "structural", + "number", + "outstanding", + "information", + "group", + "three", "mixing", - "provide", - "unpredictable", + "degrees", + "protein", + "across", + "general", "purified", "crystal", - "extremely", - "sequences", - "interactions", - "designing", - "primary", - "porous", + "stable", + "100", + "corresponding", + "encoded", + "enables", + "engineered", + "nearly", + "overall", + "biological", + "specific", + "prespecified", "contacts", + "extremely", + "approach", "develop", - "interfaces", - "general", - "architectures", - "models", - "redesigned", - "cell", - "enables", + "packing", "process", - "outstanding", - "number", - "remains", + "accuracy", + "architecture", "highly", - "materials", - "structures", - "upon", - "empirical", - "atomic", + "freedom", + "computational", "pairs", - "three", - "hierarchically", - "corresponding", - "assembly", - "biology", - "nearly", - "role", - "preferences", + "designing", + "symmetry", + "design", + "individually", "\u00b5m", + "redesigned", + "atomic", + "biology", + "empirical", + "assembly", "platform", + "porous", + "preferences", + "precisely", + "cell", + "architectures", + "constrains", + "understood", + "spontaneously", + "primary", + "upon", + "system", + "retaining", + "crystals", + "identical", + "materials", + "hierarchically", + "designed", + "central", + "models", + "dimensions", + "poorly", + "sequences", + "space", + "interfaces", + "structures", + "oligomers", + "remains", "crystallization", - "plays", + "provide", "powerful", - "100", - "group", - "programming", - "freedom", - "information", "closely", - "specific", - "engineering", - "constrains", + "interactions", + "plays", + "programming", "unit", - "design", - "across", - "symmetry", + "lattice", "high", - "prespecified", - "encoded", - "biological", - "retaining", - "individually", - "packing", - "structural", - "accuracy", - "poorly", - "overall", "despite", - "approach", - "stable", - "engineered", - "understood", - "precisely", - "system", "arrangements", - "central", - "spontaneously", - "protein", - "degrees", - "identical", - "space", - "computational", - "crystals" + "challenge", + "systematically" ], "release_date":"2023-11-01", "publication":"\"Accurate computational design of three-dimensional protein crystals\", Nat Mater, 22, 1556-1563", @@ -620204,28 +622738,16 @@ "seq_thr_sim_designed":[ { "sim":423.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":423.0, - "partner":"8cus" + "partner":"8cut" }, { "sim":398.0, "partner":"8far" }, - { - "sim":363.0, - "partner":"9dnd" - }, - { - "sim":363.0, - "partner":"9dne" - }, - { - "sim":310.0, - "partner":"6xh5" - }, { "sim":239.0, "partner":"8fwd" @@ -620240,11 +622762,11 @@ }, { "sim":99.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":99.0, - "partner":"8cqq" + "partner":"8cqp" }, { "sim":99.0, @@ -620252,27 +622774,27 @@ }, { "sim":99.0, - "partner":"8chy" + "partner":"8cmq" }, { "sim":99.0, - "partner":"8cmq" + "partner":"8bu0" }, { "sim":99.0, - "partner":"8ckr" + "partner":"8cp8" }, { "sim":99.0, - "partner":"8cig" + "partner":"8cqq" }, { "sim":99.0, - "partner":"8cqp" + "partner":"8chy" }, { "sim":99.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":98.0, @@ -620312,14 +622834,174 @@ }, { "sim":76.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":76.0, - "partner":"8ump" + "partner":"8umr" + }, + { + "sim":363.0, + "partner":"9dne" + }, + { + "sim":363.0, + "partner":"9dnd" + }, + { + "sim":310.0, + "partner":"6xh5" } ], "seq_thr_sim_natural":[ + { + "sim":380.0, + "partner":"1vlw" + }, + { + "sim":375.0, + "partner":"8e01" + }, + { + "sim":371.0, + "partner":"1wa3" + }, + { + "sim":365.0, + "partner":"5kp9" + }, + { + "sim":364.0, + "partner":"8a8n" + }, + { + "sim":360.0, + "partner":"7b3y" + }, + { + "sim":357.0, + "partner":"8ed3" + }, + { + "sim":341.0, + "partner":"8ejd" + }, + { + "sim":341.0, + "partner":"8eji" + }, + { + "sim":341.0, + "partner":"8ejf" + }, + { + "sim":341.0, + "partner":"8ejh" + }, + { + "sim":341.0, + "partner":"7sgd" + }, + { + "sim":341.0, + "partner":"7sge" + }, + { + "sim":341.0, + "partner":"7sgf" + }, + { + "sim":340.0, + "partner":"6p6f" + }, + { + "sim":110.0, + "partner":"8di1" + }, + { + "sim":104.0, + "partner":"6ovi" + }, + { + "sim":103.0, + "partner":"2yw3" + }, + { + "sim":103.0, + "partner":"2yw4" + }, + { + "sim":102.0, + "partner":"3vcr" + }, + { + "sim":100.0, + "partner":"4e38" + }, + { + "sim":97.0, + "partner":"4bk9" + }, + { + "sim":96.0, + "partner":"2v81" + }, + { + "sim":96.0, + "partner":"2v82" + }, + { + "sim":96.0, + "partner":"4qcc" + }, + { + "sim":91.0, + "partner":"1mxs" + }, + { + "sim":90.0, + "partner":"5im5" + }, + { + "sim":87.0, + "partner":"1eun" + }, + { + "sim":87.0, + "partner":"1eua" + }, + { + "sim":87.0, + "partner":"1fq0" + }, + { + "sim":86.0, + "partner":"1wau" + }, + { + "sim":86.0, + "partner":"1wbh" + }, + { + "sim":86.0, + "partner":"2c0a" + }, + { + "sim":84.0, + "partner":"5xse" + }, + { + "sim":84.0, + "partner":"5xsf" + }, + { + "sim":84.0, + "partner":"1vhc" + }, + { + "sim":83.0, + "partner":"1fwr" + }, { "sim":99.0, "partner":"7obi" @@ -620352,10 +623034,6 @@ "sim":70.0, "partner":"7y4i" }, - { - "sim":70.0, - "partner":"8dtf" - }, { "sim":70.0, "partner":"8dtg" @@ -620369,8 +623047,8 @@ "partner":"8dti" }, { - "sim":64.0, - "partner":"4rg6" + "sim":70.0, + "partner":"8dtf" }, { "sim":64.0, @@ -620382,11 +623060,7 @@ }, { "sim":64.0, - "partner":"5lcw" - }, - { - "sim":64.0, - "partner":"6q6g" + "partner":"4rg6" }, { "sim":64.0, @@ -620410,16 +623084,12 @@ }, { "sim":64.0, - "partner":"8pkp" + "partner":"6tlj" }, { "sim":64.0, "partner":"5l9u" }, - { - "sim":64.0, - "partner":"6tlj" - }, { "sim":64.0, "partner":"6q6h" @@ -620432,6 +623102,10 @@ "sim":64.0, "partner":"5a31" }, + { + "sim":64.0, + "partner":"8pkp" + }, { "sim":64.0, "partner":"5g05" @@ -620444,10 +623118,18 @@ "sim":64.0, "partner":"4ui9" }, + { + "sim":64.0, + "partner":"6q6g" + }, { "sim":64.0, "partner":"8tau" }, + { + "sim":64.0, + "partner":"5lcw" + }, { "sim":60.0, "partner":"3cvl" @@ -620476,10 +623158,6 @@ "sim":58.0, "partner":"2c0m" }, - { - "sim":58.0, - "partner":"4kyo" - }, { "sim":58.0, "partner":"3r9a" @@ -620492,6 +623170,10 @@ "sim":58.0, "partner":"4kxk" }, + { + "sim":58.0, + "partner":"4kyo" + }, { "sim":58.0, "partner":"1fch" @@ -620506,19 +623188,19 @@ }, { "sim":56.0, - "partner":"6voa" + "partner":"6vbu" }, { "sim":56.0, - "partner":"6vnw" + "partner":"6vbv" }, { "sim":56.0, - "partner":"6vbu" + "partner":"6voa" }, { "sim":56.0, - "partner":"6vbv" + "partner":"6vnw" }, { "sim":56.0, @@ -620539,154 +623221,6 @@ { "sim":51.0, "partner":"8a3t" - }, - { - "sim":380.0, - "partner":"1vlw" - }, - { - "sim":375.0, - "partner":"8e01" - }, - { - "sim":371.0, - "partner":"1wa3" - }, - { - "sim":365.0, - "partner":"5kp9" - }, - { - "sim":364.0, - "partner":"8a8n" - }, - { - "sim":360.0, - "partner":"7b3y" - }, - { - "sim":357.0, - "partner":"8ed3" - }, - { - "sim":341.0, - "partner":"8ejh" - }, - { - "sim":341.0, - "partner":"8ejd" - }, - { - "sim":341.0, - "partner":"8eji" - }, - { - "sim":341.0, - "partner":"8ejf" - }, - { - "sim":341.0, - "partner":"7sgd" - }, - { - "sim":341.0, - "partner":"7sge" - }, - { - "sim":341.0, - "partner":"7sgf" - }, - { - "sim":340.0, - "partner":"6p6f" - }, - { - "sim":110.0, - "partner":"8di1" - }, - { - "sim":104.0, - "partner":"6ovi" - }, - { - "sim":103.0, - "partner":"2yw3" - }, - { - "sim":103.0, - "partner":"2yw4" - }, - { - "sim":102.0, - "partner":"3vcr" - }, - { - "sim":100.0, - "partner":"4e38" - }, - { - "sim":97.0, - "partner":"4bk9" - }, - { - "sim":96.0, - "partner":"2v81" - }, - { - "sim":96.0, - "partner":"2v82" - }, - { - "sim":96.0, - "partner":"4qcc" - }, - { - "sim":91.0, - "partner":"1mxs" - }, - { - "sim":90.0, - "partner":"5im5" - }, - { - "sim":87.0, - "partner":"1eun" - }, - { - "sim":87.0, - "partner":"1eua" - }, - { - "sim":87.0, - "partner":"1fq0" - }, - { - "sim":86.0, - "partner":"1wau" - }, - { - "sim":86.0, - "partner":"1wbh" - }, - { - "sim":86.0, - "partner":"2c0a" - }, - { - "sim":84.0, - "partner":"5xse" - }, - { - "sim":84.0, - "partner":"5xsf" - }, - { - "sim":84.0, - "partner":"1vhc" - }, - { - "sim":83.0, - "partner":"1fwr" } ], "struct_thr_sim_designed":[ @@ -620708,7 +623242,7 @@ ], "seq_max_sim_designed":{ "sim":423.0, - "partner":"8cut" + "partner":"8cus" }, "seq_max_sim_natural":{ "sim":380.0, @@ -620844,72 +623378,72 @@ "hallucination protein mpnn" ], "keywords":[ - "enabling", - "accuracy", - "performance", - "monomers", - "demonstrate", - "designs", - "revolutionized", - "tests", - "chains", - "functional", - "amino", - "proteinmpnn", - "challenges", - "studies", - "failed", - "multiple", + "made", + "recovery", "alphafold", - "proteins", + "coupled", + "characterized", + "design", + "backbones", + "learning", + "compared", + "current", + "experimental", "de", - "novo", - "outstanding", - "although", "single", - "wide", - "characterized", + "outstanding", + "functional", + "multiple", + "approaches", + "enabling", "nanoparticles", - "rosetta", - "experimental", - "acid", "almost", - "crystallography", - "method", - "prediction", - "generated", - "different", - "recovery", - "approaches", - "broad", - "current", "experimentally", - "made", - "application", + "different", + "previously", "based", - "design", + "monomers", + "application", + "structure", + "rosetta", + "acid", + "challenges", + "although", + "prediction", + "cyclic", + "crystallography", "protein", - "physically", - "using", + "performance", + "amino", + "wide", "positions", - "microscopy", + "rescuing", + "failed", "tetrahedral", - "describe", - "structure", - "high", - "sequence", - "native", "silico", - "compared", - "deep", - "backbones", - "learning", - "coupled", - "cyclic", - "rescuing", + "proteins", "utility", - "previously", - "range" + "accuracy", + "broad", + "microscopy", + "revolutionized", + "novo", + "high", + "demonstrate", + "native", + "sequence", + "tests", + "generated", + "studies", + "physically", + "describe", + "chains", + "range", + "designs", + "method", + "using", + "proteinmpnn", + "deep" ], "release_date":"2022-09-28", "publication":"\"Robust deep learning-based protein sequence design using ProteinMPNN\", Science, 378, 49-56", @@ -621058,79 +623592,79 @@ ], "subtitle":"Hallucinated c2 protein assembly halc2_068", "tags":[ - "de novo design hallucination cyclic oligomer proteinmpnn", - "de novo protein" + "de novo protein", + "de novo design hallucination cyclic oligomer proteinmpnn" ], "keywords":[ - "1550", - "seven", - "protomer", - "differ", - "designs", - "results", - "network", - "proteins", + "c", + "complex", + "highlight", "models", - "solved", - "components", - "use", - "similar", - "hallucination", - "generate", - "nanomachines", - "wide", + "median", + "protomers", + "angstroms", + "sequences", + "symmetry", + "design", + "space", + "learning", + "specification", "length", - "pave", "way", - "rings", "number", + "structures", + "hallucination", + "natural", + "approaches", + "previously", + "three", "deviation", - "square", - "generated", + "giant", + "structure", "residues", - "approaches", + "rich", + "mean", "provide", - "median", + "results", + "diversity", "beyond", - "symmetric", - "crystal", - "giant", "new", - "biomaterials", - "generative", - "increasingly", - "design", + "1550", + "root", "explore", - "sequences", - "highlight", - "structures", + "network", "protein", - "angstroms", - "microscopy", + "wide", "given", + "proteins", + "symmetric", + "pave", + "microscopy", + "use", + "nanomachines", + "broadly", + "solved", + "seven", "considerably", - "protomers", + "generated", + "components", + "increasingly", + "generative", + "rings", + "crystal", "using", + "biomaterials", + "range", + "designs", + "square", + "protomer", + "similar", "opportunity", - "natural", - "space", - "symmetry", - "specification", - "structure", - "three", - "c", - "mean", - "diversity", - "broadly", - "root", "computational", - "rich", + "generate", "33", "deep", - "learning", - "complex", - "previously", - "range" + "differ" ], "release_date":"2022-09-28", "publication":"\"Hallucinating symmetric protein assemblies\", Science, 378, 56-61", @@ -621283,75 +623817,75 @@ "de novo design hallucination cyclic proteinmpnn" ], "keywords":[ - "1550", - "seven", - "protomer", - "differ", - "designs", - "results", - "network", - "proteins", + "c", + "complex", + "highlight", "models", - "solved", - "components", - "use", - "similar", - "hallucination", - "generate", - "nanomachines", - "wide", + "median", + "protomers", + "angstroms", + "sequences", + "symmetry", + "design", + "space", + "learning", + "specification", "length", - "pave", "way", - "rings", "number", + "structures", + "hallucination", + "natural", + "approaches", + "previously", + "three", "deviation", - "square", - "generated", + "giant", + "structure", "residues", - "approaches", + "rich", + "mean", "provide", - "median", + "results", + "diversity", "beyond", - "symmetric", - "crystal", - "giant", "new", - "biomaterials", - "generative", - "increasingly", - "design", + "1550", + "root", "explore", - "sequences", - "highlight", - "structures", + "network", "protein", - "angstroms", - "microscopy", + "wide", "given", + "proteins", + "symmetric", + "pave", + "microscopy", + "use", + "nanomachines", + "broadly", + "solved", + "seven", "considerably", - "protomers", + "generated", + "components", + "increasingly", + "generative", + "rings", + "crystal", "using", + "biomaterials", + "range", + "designs", + "square", + "protomer", + "similar", "opportunity", - "natural", - "space", - "symmetry", - "specification", - "structure", - "three", - "c", - "mean", - "diversity", - "broadly", - "root", "computational", - "rich", + "generate", "33", "deep", - "learning", - "complex", - "previously", - "range" + "differ" ], "release_date":"2022-09-28", "publication":"\"Hallucinating symmetric protein assemblies\", Science, 378, 56-61", @@ -621500,79 +624034,79 @@ ], "subtitle":"Hallucinated c2 protein assembly halc2_065", "tags":[ - "de novo design hallucination cyclic oligomer proteinmpnn", - "de novo protein" + "de novo protein", + "de novo design hallucination cyclic oligomer proteinmpnn" ], "keywords":[ - "1550", - "seven", - "protomer", - "differ", - "designs", - "results", - "network", - "proteins", + "c", + "complex", + "highlight", "models", - "solved", - "components", - "use", - "similar", - "hallucination", - "generate", - "nanomachines", - "wide", + "median", + "protomers", + "angstroms", + "sequences", + "symmetry", + "design", + "space", + "learning", + "specification", "length", - "pave", "way", - "rings", "number", + "structures", + "hallucination", + "natural", + "approaches", + "previously", + "three", "deviation", - "square", - "generated", + "giant", + "structure", "residues", - "approaches", + "rich", + "mean", "provide", - "median", + "results", + "diversity", "beyond", - "symmetric", - "crystal", - "giant", "new", - "biomaterials", - "generative", - "increasingly", - "design", + "1550", + "root", "explore", - "sequences", - "highlight", - "structures", + "network", "protein", - "angstroms", - "microscopy", + "wide", "given", + "proteins", + "symmetric", + "pave", + "microscopy", + "use", + "nanomachines", + "broadly", + "solved", + "seven", "considerably", - "protomers", + "generated", + "components", + "increasingly", + "generative", + "rings", + "crystal", "using", + "biomaterials", + "range", + "designs", + "square", + "protomer", + "similar", "opportunity", - "natural", - "space", - "symmetry", - "specification", - "structure", - "three", - "c", - "mean", - "diversity", - "broadly", - "root", "computational", - "rich", + "generate", "33", "deep", - "learning", - "complex", - "previously", - "range" + "differ" ], "release_date":"2022-09-28", "publication":"\"Hallucinating symmetric protein assemblies\", Science, 378, 56-61", @@ -621721,79 +624255,79 @@ ], "subtitle":"Hallucinated c3 protein assembly halc3_104", "tags":[ - "de novo design hallucination cyclic oligomer proteinmpnn", - "de novo protein" + "de novo protein", + "de novo design hallucination cyclic oligomer proteinmpnn" ], "keywords":[ - "1550", - "seven", - "protomer", - "differ", - "designs", - "results", - "network", - "proteins", + "c", + "complex", + "highlight", "models", - "solved", - "components", - "use", - "similar", - "hallucination", - "generate", - "nanomachines", - "wide", + "median", + "protomers", + "angstroms", + "sequences", + "symmetry", + "design", + "space", + "learning", + "specification", "length", - "pave", "way", - "rings", "number", + "structures", + "hallucination", + "natural", + "approaches", + "previously", + "three", "deviation", - "square", - "generated", + "giant", + "structure", "residues", - "approaches", + "rich", + "mean", "provide", - "median", + "results", + "diversity", "beyond", - "symmetric", - "crystal", - "giant", "new", - "biomaterials", - "generative", - "increasingly", - "design", + "1550", + "root", "explore", - "sequences", - "highlight", - "structures", + "network", "protein", - "angstroms", - "microscopy", + "wide", "given", + "proteins", + "symmetric", + "pave", + "microscopy", + "use", + "nanomachines", + "broadly", + "solved", + "seven", "considerably", - "protomers", + "generated", + "components", + "increasingly", + "generative", + "rings", + "crystal", "using", + "biomaterials", + "range", + "designs", + "square", + "protomer", + "similar", "opportunity", - "natural", - "space", - "symmetry", - "specification", - "structure", - "three", - "c", - "mean", - "diversity", - "broadly", - "root", "computational", - "rich", + "generate", "33", "deep", - "learning", - "complex", - "previously", - "range" + "differ" ], "release_date":"2022-09-28", "publication":"\"Hallucinating symmetric protein assemblies\", Science, 378, 56-61", @@ -621942,79 +624476,79 @@ ], "subtitle":"Hallucinated c3 protein assembly halc3_109", "tags":[ - "de novo design hallucination cyclic oligomer proteinmpnn", - "de novo protein" + "de novo protein", + "de novo design hallucination cyclic oligomer proteinmpnn" ], "keywords":[ - "1550", - "seven", - "protomer", - "differ", - "designs", - "results", - "network", - "proteins", + "c", + "complex", + "highlight", "models", - "solved", - "components", - "use", - "similar", - "hallucination", - "generate", - "nanomachines", - "wide", + "median", + "protomers", + "angstroms", + "sequences", + "symmetry", + "design", + "space", + "learning", + "specification", "length", - "pave", "way", - "rings", "number", + "structures", + "hallucination", + "natural", + "approaches", + "previously", + "three", "deviation", - "square", - "generated", + "giant", + "structure", "residues", - "approaches", + "rich", + "mean", "provide", - "median", + "results", + "diversity", "beyond", - "symmetric", - "crystal", - "giant", "new", - "biomaterials", - "generative", - "increasingly", - "design", + "1550", + "root", "explore", - "sequences", - "highlight", - "structures", + "network", "protein", - "angstroms", - "microscopy", + "wide", "given", + "proteins", + "symmetric", + "pave", + "microscopy", + "use", + "nanomachines", + "broadly", + "solved", + "seven", "considerably", - "protomers", + "generated", + "components", + "increasingly", + "generative", + "rings", + "crystal", "using", + "biomaterials", + "range", + "designs", + "square", + "protomer", + "similar", "opportunity", - "natural", - "space", - "symmetry", - "specification", - "structure", - "three", - "c", - "mean", - "diversity", - "broadly", - "root", "computational", - "rich", + "generate", "33", "deep", - "learning", - "complex", - "previously", - "range" + "differ" ], "release_date":"2022-09-28", "publication":"\"Hallucinating symmetric protein assemblies\", Science, 378, 56-61", @@ -622163,79 +624697,79 @@ ], "subtitle":"Hallucinated c4 protein assembly halc4_135", "tags":[ - "de novo design hallucination cyclic oligomer proteinmpnn", - "de novo protein" + "de novo protein", + "de novo design hallucination cyclic oligomer proteinmpnn" ], "keywords":[ - "1550", - "seven", - "protomer", - "differ", - "designs", - "results", - "network", - "proteins", + "c", + "complex", + "highlight", "models", - "solved", - "components", - "use", - "similar", - "hallucination", - "generate", - "nanomachines", - "wide", + "median", + "protomers", + "angstroms", + "sequences", + "symmetry", + "design", + "space", + "learning", + "specification", "length", - "pave", "way", - "rings", "number", + "structures", + "hallucination", + "natural", + "approaches", + "previously", + "three", "deviation", - "square", - "generated", + "giant", + "structure", "residues", - "approaches", + "rich", + "mean", "provide", - "median", + "results", + "diversity", "beyond", - "symmetric", - "crystal", - "giant", "new", - "biomaterials", - "generative", - "increasingly", - "design", + "1550", + "root", "explore", - "sequences", - "highlight", - "structures", + "network", "protein", - "angstroms", - "microscopy", + "wide", "given", + "proteins", + "symmetric", + "pave", + "microscopy", + "use", + "nanomachines", + "broadly", + "solved", + "seven", "considerably", - "protomers", + "generated", + "components", + "increasingly", + "generative", + "rings", + "crystal", "using", + "biomaterials", + "range", + "designs", + "square", + "protomer", + "similar", "opportunity", - "natural", - "space", - "symmetry", - "specification", - "structure", - "three", - "c", - "mean", - "diversity", - "broadly", - "root", "computational", - "rich", + "generate", "33", "deep", - "learning", - "complex", - "previously", - "range" + "differ" ], "release_date":"2022-09-28", "publication":"\"Hallucinating symmetric protein assemblies\", Science, 378, 56-61", @@ -622384,79 +624918,79 @@ ], "subtitle":"Hallucinated c4 protein assembly halc4_136", "tags":[ - "de novo design hallucination cyclic oligomer proteinmpnn", - "de novo protein" + "de novo protein", + "de novo design hallucination cyclic oligomer proteinmpnn" ], "keywords":[ - "1550", - "seven", - "protomer", - "differ", - "designs", - "results", - "network", - "proteins", + "c", + "complex", + "highlight", "models", - "solved", - "components", - "use", - "similar", - "hallucination", - "generate", - "nanomachines", - "wide", + "median", + "protomers", + "angstroms", + "sequences", + "symmetry", + "design", + "space", + "learning", + "specification", "length", - "pave", "way", - "rings", "number", + "structures", + "hallucination", + "natural", + "approaches", + "previously", + "three", "deviation", - "square", - "generated", + "giant", + "structure", "residues", - "approaches", + "rich", + "mean", "provide", - "median", + "results", + "diversity", "beyond", - "symmetric", - "crystal", - "giant", "new", - "biomaterials", - "generative", - "increasingly", - "design", + "1550", + "root", "explore", - "sequences", - "highlight", - "structures", + "network", "protein", - "angstroms", - "microscopy", + "wide", "given", + "proteins", + "symmetric", + "pave", + "microscopy", + "use", + "nanomachines", + "broadly", + "solved", + "seven", "considerably", - "protomers", + "generated", + "components", + "increasingly", + "generative", + "rings", + "crystal", "using", + "biomaterials", + "range", + "designs", + "square", + "protomer", + "similar", "opportunity", - "natural", - "space", - "symmetry", - "specification", - "structure", - "three", - "c", - "mean", - "diversity", - "broadly", - "root", "computational", - "rich", + "generate", "33", "deep", - "learning", - "complex", - "previously", - "range" + "differ" ], "release_date":"2022-09-28", "publication":"\"Hallucinating symmetric protein assemblies\", Science, 378, 56-61", @@ -622552,8 +625086,8 @@ ], "subtitle":"Pross petase", "tags":[ - "plastic", - "hydrolase" + "hydrolase", + "plastic" ], "keywords":[ "description", @@ -622590,11 +625124,11 @@ "seq_thr_sim_designed":[ { "sim":293.0, - "partner":"8etx" + "partner":"8eu1" }, { "sim":293.0, - "partner":"8eu1" + "partner":"8etx" }, { "sim":292.0, @@ -622636,11 +625170,11 @@ }, { "sim":495.0, - "partner":"6kuq" + "partner":"6ij5" }, { "sim":495.0, - "partner":"6ij5" + "partner":"6kuq" }, { "sim":494.0, @@ -622652,23 +625186,23 @@ }, { "sim":486.0, - "partner":"6eqd" + "partner":"6eqg" }, { "sim":486.0, - "partner":"6eqe" + "partner":"6eqh" }, { "sim":486.0, - "partner":"6eqf" + "partner":"6eqd" }, { "sim":486.0, - "partner":"6eqg" + "partner":"6eqe" }, { "sim":486.0, - "partner":"6eqh" + "partner":"6eqf" }, { "sim":485.0, @@ -622824,11 +625358,11 @@ }, { "sim":249.0, - "partner":"7e31" + "partner":"7w69" }, { "sim":249.0, - "partner":"7w69" + "partner":"7e31" }, { "sim":249.0, @@ -622838,10 +625372,6 @@ "sim":248.0, "partner":"7nei" }, - { - "sim":246.0, - "partner":"7e30" - }, { "sim":246.0, "partner":"7cuv" @@ -622854,6 +625384,10 @@ "sim":246.0, "partner":"7w6o" }, + { + "sim":246.0, + "partner":"7e30" + }, { "sim":246.0, "partner":"7w6q" @@ -622946,6 +625480,26 @@ "sim":215.0, "partner":"7eoa" }, + { + "sim":204.0, + "partner":"8ytu" + }, + { + "sim":198.0, + "partner":"8ytv" + }, + { + "sim":195.0, + "partner":"8ytw" + }, + { + "sim":191.0, + "partner":"8ytz" + }, + { + "sim":190.0, + "partner":"8yty" + }, { "sim":167.0, "partner":"7pzj" @@ -623050,7 +625604,7 @@ ], "seq_max_sim_designed":{ "sim":293.0, - "partner":"8etx" + "partner":"8eu1" }, "seq_max_sim_natural":{ "sim":499.0, @@ -623108,116 +625662,116 @@ ], "subtitle":"De novo photosynthetic reaction center protein in apo-state", "tags":[ - "charge separation", - "artificial photosynthesis", - "maquette", "de novo protein", - "protein design" + "maquette", + "artificial photosynthesis", + "protein design", + "charge separation" ], "keywords":[ - "ordered", - "use", - "close", - "strategy", - "metal", - "ions", - "substantially", - "designed", + "affinity", + "technologies", "allow", - "uses", - "fossil", - "cofactors", - "crystal", + "biofuels", + "structural", + "fuels", "show", + "separation", + "donors", "critique", - "zn", - "recently", - "intended", - "affinity", "acceptors", - "spectroscopic", - "chain", - "detail", - "donors", - "technologies", - "de", - "produce", - "collapses", - "efficient", - "conversion", - "dependence", - "illustrate", + "photon", + "tyrosine", "assays", - "binds", - "nature", - "shift", - "separation", - "assemble", - "production", - "efficiency", + "new", + "heme", + "strategy", + "cofactors", + "various", + "protein", + "illustrate", + "electron", + "binding", + "thermodynamic", + "close", + "novo", "centers", - "structures", + "demonstrate", + "crystal", + "global", + "binds", + "theory", + "zn", + "reaction", + "path", "dynamic", - "upon", - "center", + "metal", "renewable", - "natural", - "transitions", - "assembly", + "reactions", + "cascade", "rc", - "envision", - "facilitate", - "toward", - "higher", + "charge", + "intended", + "pigments", + "day", + "ions", + "use", + "described", + "modular", + "may", + "center", + "agrees", "chemical", - "thermodynamic", - "photosynthetic", - "reactions", + "higher", "maquette", - "may", - "activity", - "help", - "photosystems", + "facilitate", + "collapses", + "spectroscopic", + "fossil", "design", - "tyrosine", - "deepens", + "energy", + "tetrapyrrole", + "chain", + "help", + "natural", + "produce", + "different", + "transitions", + "assembly", + "shift", + "fuel", + "upon", "states", + "uses", + "substantially", + "toward", "present", - "path", - "high", - "energy", - "structural", + "cofactor", + "dependence", + "production", + "designed", "convert", - "fuel", - "demonstrate", + "photosystems", + "efficient", "one", - "tetrapyrrole", - "described", - "novo", - "cofactor", + "structures", + "de", "rational", - "flexible", - "heme", - "charge", - "modular", - "electron", - "different", - "reaction", - "day", - "pigments", - "biofuels", + "photosynthetic", "eventually", - "fuels", - "binding", - "protein", - "agrees", - "theory", - "various", + "flexible", + "recently", + "nature", "understanding", - "photon", - "global", - "cascade", - "new" + "detail", + "high", + "activity", + "deepens", + "envision", + "efficiency", + "assemble", + "ordered", + "conversion" ], "release_date":"2022-09-28", "publication":"\"Rational design of photosynthetic reaction center protein maquettes\", Front Mol Biosci, 9, 997295-997295", @@ -623250,15 +625804,15 @@ "seq_thr_sim_designed":[ { "sim":351.0, - "partner":"5vjt" + "partner":"5vjs" }, { "sim":351.0, - "partner":"8d9p" + "partner":"5vjt" }, { "sim":351.0, - "partner":"5vjs" + "partner":"8d9p" }, { "sim":346.0, @@ -623280,11 +625834,11 @@ }, { "sim":66.0, - "partner":"1u7m" + "partner":"1mft" }, { "sim":66.0, - "partner":"1mft" + "partner":"1u7m" }, { "sim":64.0, @@ -623307,7 +625861,7 @@ ], "seq_max_sim_designed":{ "sim":351.0, - "partner":"5vjt" + "partner":"5vjs" }, "seq_max_sim_natural":{ "sim":279.0, @@ -623365,116 +625919,116 @@ ], "subtitle":"De novo photosynthetic reaction center protein equipped with heme b and mn(ii) cations", "tags":[ - "charge separation", - "artificial photosynthesis", - "maquette", "de novo protein", - "protein design" + "maquette", + "artificial photosynthesis", + "protein design", + "charge separation" ], "keywords":[ - "ordered", - "use", - "close", - "strategy", - "metal", - "ions", - "substantially", - "designed", + "affinity", + "technologies", "allow", - "uses", - "fossil", - "cofactors", - "crystal", + "biofuels", + "structural", + "fuels", "show", + "separation", + "donors", "critique", - "zn", - "recently", - "intended", - "affinity", "acceptors", - "spectroscopic", - "chain", - "detail", - "donors", - "technologies", - "de", - "produce", - "collapses", - "efficient", - "conversion", - "dependence", - "illustrate", + "photon", + "tyrosine", "assays", - "binds", - "nature", - "shift", - "separation", - "assemble", - "production", - "efficiency", + "new", + "heme", + "strategy", + "cofactors", + "various", + "protein", + "illustrate", + "electron", + "binding", + "thermodynamic", + "close", + "novo", "centers", - "structures", + "demonstrate", + "crystal", + "global", + "binds", + "theory", + "zn", + "reaction", + "path", "dynamic", - "upon", - "center", + "metal", "renewable", - "natural", - "transitions", - "assembly", + "reactions", + "cascade", "rc", - "envision", - "facilitate", - "toward", - "higher", + "charge", + "intended", + "pigments", + "day", + "ions", + "use", + "described", + "modular", + "may", + "center", + "agrees", "chemical", - "thermodynamic", - "photosynthetic", - "reactions", + "higher", "maquette", - "may", - "activity", - "help", - "photosystems", + "facilitate", + "collapses", + "spectroscopic", + "fossil", "design", - "tyrosine", - "deepens", + "energy", + "tetrapyrrole", + "chain", + "help", + "natural", + "produce", + "different", + "transitions", + "assembly", + "shift", + "fuel", + "upon", "states", + "uses", + "substantially", + "toward", "present", - "path", - "high", - "energy", - "structural", + "cofactor", + "dependence", + "production", + "designed", "convert", - "fuel", - "demonstrate", + "photosystems", + "efficient", "one", - "tetrapyrrole", - "described", - "novo", - "cofactor", + "structures", + "de", "rational", - "flexible", - "heme", - "charge", - "modular", - "electron", - "different", - "reaction", - "day", - "pigments", - "biofuels", + "photosynthetic", "eventually", - "fuels", - "binding", - "protein", - "agrees", - "theory", - "various", + "flexible", + "recently", + "nature", "understanding", - "photon", - "global", - "cascade", - "new" + "detail", + "high", + "activity", + "deepens", + "envision", + "efficiency", + "assemble", + "ordered", + "conversion" ], "release_date":"2022-09-28", "publication":"\"Rational design of photosynthetic reaction center protein maquettes\", Front Mol Biosci, 9, 997295-997295", @@ -623507,7 +626061,7 @@ "seq_thr_sim_designed":[ { "sim":351.0, - "partner":"8d9o" + "partner":"5vjs" }, { "sim":351.0, @@ -623515,7 +626069,7 @@ }, { "sim":351.0, - "partner":"5vjs" + "partner":"8d9o" }, { "sim":346.0, @@ -623537,11 +626091,11 @@ }, { "sim":66.0, - "partner":"1u7m" + "partner":"1mft" }, { "sim":66.0, - "partner":"1mft" + "partner":"1u7m" }, { "sim":64.0, @@ -623567,7 +626121,7 @@ ], "seq_max_sim_designed":{ "sim":351.0, - "partner":"8d9o" + "partner":"5vjs" }, "seq_max_sim_natural":{ "sim":279.0, @@ -623649,100 +626203,100 @@ ], "subtitle":"Quasi-racemic mixture of l-fwf and d-fyf peptide reveals rippled beta-sheet", "tags":[ + "protein fibril", "quasi-racemic peptides", - "rippled beta-sheet", - "protein fibril" + "rippled beta-sheet" ], "keywords":[ - "work", - "viable", - "opens", - "periodic", + "whether", + "structural", + "pauling", + "experimental", + "validity", + "establishes", + "question", + "conducted", + "predictions", + "peptidic", + "extended", + "model", + "study", + "certain", + "layers", + "motif", + "urgently", "countless", - "road", + "general", + "aggregating", + "systems", + "motifs", + "two", + "related", + "crystal", + "gained", + "supramolecular", + "textbook", + "knowledge", + "antiparallel", + "shows", + "periodic", + "agreement", "thus", + "noteworthy", + "layer", + "pleated", + "viable", + "proteins", + "published", + "since", + "features", "peptide", - "year", + "stopped", + "configuration", + "design", + "moreover", + "crystallized", + "work", + "past", + "field", + "assembly", + "considered", "prediction", - "determine", + "architectures", "1950s", - "noteworthy", - "crystal", - "urgently", - "features", - "stage", + "solution", + "foundation", + "predicted", "needs", - "recently", - "pauling", - "general", - "architectures", + "common", + "peptides", "excellent", - "pleated", - "proteins", - "hypothesized", + "determine", "unique", - "whether", - "crystallized", + "year", "decade", - "motif", - "published", - "structures", - "foundation", - "solution", - "assembly", - "conducted", - "motifs", "form", - "layers", - "shows", + "road", + "one", + "rather", + "opens", + "observed", + "structures", + "conversely", "first", - "field", - "systems", - "layer", - "certain", - "common", - "predictions", - "extended", "report", "meaningful", - "moreover", - "configuration", - "aggregating", - "agreement", - "observed", - "design", - "conversely", - "model", - "validity", - "calling", - "rather", + "recently", "nmr", + "yield", "topography", - "textbook", - "structural", "racemic", - "predicted", - "supramolecular", - "past", - "question", - "corey", - "one", - "study", - "experimental", - "peptides", - "establishes", - "stopped", - "two", - "antiparallel", - "considered", - "yield", - "peptidic", - "knowledge", "distinct", - "gained", + "calling", + "corey", + "stage", "rippled", - "since", - "related" + "hypothesized" ], "release_date":"2022-09-28", "publication":"\"The rippled beta-sheet layer configuration-a novel supramolecular architecture based on predictions by Pauling and Corey\", Chem Sci, 13, 8947-8952", @@ -623856,100 +626410,100 @@ ], "subtitle":"Fyf peptide forms a standard beta-sheet", "tags":[ - "rippled beta-sheet", "protein fibril", - "racemic peptide" + "racemic peptide", + "rippled beta-sheet" ], "keywords":[ - "work", - "viable", - "opens", - "periodic", + "whether", + "structural", + "pauling", + "experimental", + "validity", + "establishes", + "question", + "conducted", + "predictions", + "peptidic", + "extended", + "model", + "study", + "certain", + "layers", + "motif", + "urgently", "countless", - "road", + "general", + "aggregating", + "systems", + "motifs", + "two", + "related", + "crystal", + "gained", + "supramolecular", + "textbook", + "knowledge", + "antiparallel", + "shows", + "periodic", + "agreement", "thus", + "noteworthy", + "layer", + "pleated", + "viable", + "proteins", + "published", + "since", + "features", "peptide", - "year", + "stopped", + "configuration", + "design", + "moreover", + "crystallized", + "work", + "past", + "field", + "assembly", + "considered", "prediction", - "determine", + "architectures", "1950s", - "noteworthy", - "crystal", - "urgently", - "features", - "stage", + "solution", + "foundation", + "predicted", "needs", - "recently", - "pauling", - "general", - "architectures", + "common", + "peptides", "excellent", - "pleated", - "proteins", - "hypothesized", + "determine", "unique", - "whether", - "crystallized", + "year", "decade", - "motif", - "published", - "structures", - "foundation", - "solution", - "assembly", - "conducted", - "motifs", "form", - "layers", - "shows", + "road", + "one", + "rather", + "opens", + "observed", + "structures", + "conversely", "first", - "field", - "systems", - "layer", - "certain", - "common", - "predictions", - "extended", "report", "meaningful", - "moreover", - "configuration", - "aggregating", - "agreement", - "observed", - "design", - "conversely", - "model", - "validity", - "calling", - "rather", + "recently", "nmr", + "yield", "topography", - "textbook", - "structural", "racemic", - "predicted", - "supramolecular", - "past", - "question", - "corey", - "one", - "study", - "experimental", - "peptides", - "establishes", - "stopped", - "two", - "antiparallel", - "considered", - "yield", - "peptidic", - "knowledge", "distinct", - "gained", + "calling", + "corey", + "stage", "rippled", - "since", - "related" + "hypothesized" ], "release_date":"2022-09-28", "publication":"\"The rippled beta-sheet layer configuration-a novel supramolecular architecture based on predictions by Pauling and Corey\", Chem Sci, 13, 8947-8952", @@ -624063,100 +626617,100 @@ ], "subtitle":"Racemic mixture of fyf peptide reveals rippled beta-sheet", "tags":[ - "rippled beta-sheet", "protein fibril", - "racemic peptide" + "racemic peptide", + "rippled beta-sheet" ], "keywords":[ - "work", - "viable", - "opens", - "periodic", + "whether", + "structural", + "pauling", + "experimental", + "validity", + "establishes", + "question", + "conducted", + "predictions", + "peptidic", + "extended", + "model", + "study", + "certain", + "layers", + "motif", + "urgently", "countless", - "road", + "general", + "aggregating", + "systems", + "motifs", + "two", + "related", + "crystal", + "gained", + "supramolecular", + "textbook", + "knowledge", + "antiparallel", + "shows", + "periodic", + "agreement", "thus", + "noteworthy", + "layer", + "pleated", + "viable", + "proteins", + "published", + "since", + "features", "peptide", - "year", + "stopped", + "configuration", + "design", + "moreover", + "crystallized", + "work", + "past", + "field", + "assembly", + "considered", "prediction", - "determine", + "architectures", "1950s", - "noteworthy", - "crystal", - "urgently", - "features", - "stage", + "solution", + "foundation", + "predicted", "needs", - "recently", - "pauling", - "general", - "architectures", + "common", + "peptides", "excellent", - "pleated", - "proteins", - "hypothesized", + "determine", "unique", - "whether", - "crystallized", + "year", "decade", - "motif", - "published", - "structures", - "foundation", - "solution", - "assembly", - "conducted", - "motifs", "form", - "layers", - "shows", + "road", + "one", + "rather", + "opens", + "observed", + "structures", + "conversely", "first", - "field", - "systems", - "layer", - "certain", - "common", - "predictions", - "extended", "report", "meaningful", - "moreover", - "configuration", - "aggregating", - "agreement", - "observed", - "design", - "conversely", - "model", - "validity", - "calling", - "rather", + "recently", "nmr", + "yield", "topography", - "textbook", - "structural", "racemic", - "predicted", - "supramolecular", - "past", - "question", - "corey", - "one", - "study", - "experimental", - "peptides", - "establishes", - "stopped", - "two", - "antiparallel", - "considered", - "yield", - "peptidic", - "knowledge", "distinct", - "gained", + "calling", + "corey", + "stage", "rippled", - "since", - "related" + "hypothesized" ], "release_date":"2022-09-28", "publication":"\"The rippled beta-sheet layer configuration-a novel supramolecular architecture based on predictions by Pauling and Corey\", Chem Sci, 13, 8947-8952", @@ -624259,91 +626813,91 @@ "subtitle":"Synthetic beta sheet macrocycle stabilized by hydrogen bond surrogates", "tags":[ "de novo protein", - "beta sheet", - "synthetic peptide" + "synthetic peptide", + "beta sheet" ], "keywords":[ - "facile", - "providing", - "bonds", - "acid", - "crystallography", - "designed", - "robust", + "superior", + "highlighted", + "requirement", "pairings", - "ionic", - "support", - "find", "show", - "interactions", - "synthetic", + "macrocyclic", + "side", + "lead", + "dataset", + "acid", + "residue", + "protein", "bioinformatics", + "correspondence", + "terminal", + "circular", + "offer", + "hbs", + "secondary", + "isolated", + "robust", + "tertiary", + "chemistry", + "typically", + "antiparallel", + "conformational", + "survey", + "surrogates", "access", - "structure", - "minimal", - "inhibitors", - "turn", - "principles", + "specific", + "protocol", + "incorporated", "phase", - "aromatic", - "dataset", - "isolated", - "without", + "stability", + "may", + "hydrogen", + "bond", + "along", + "bioorganic", + "solid", + "design", "chain", - "biomolecular", - "hypothesized", - "requirement", - "typically", - "highlighted", - "mimic", - "lead", - "naturally", + "principles", "natural", - "tertiary", - "macrocyclic", - "circular", - "hydrogen", - "history", - "stability", - "replacement", + "interstrand", + "synthesis", + "mimic", + "bonds", + "biomolecular", "amino", - "incorporated", - "thereby", + "formation", + "segments", + "ionic", + "history", "developed", - "surrogates", - "may", - "synthesis", - "protocol", - "specific", + "minimal", + "designed", + "spectroscopies", + "naturally", + "aromatic", + "providing", "observed", - "design", - "bond", - "secondary", + "endow", + "without", + "structure", + "synthetic", + "thereby", + "crystallography", "nmr", - "segments", - "formation", - "hbs", - "correspondence", + "interactions", + "inhibitors", + "surveyed", "mimics", - "chemistry", - "interstrand", - "conformational", - "endow", "storied", - "offer", - "along", - "solid", - "bioorganic", - "antiparallel", - "survey", - "protein", - "residue", - "superior", - "surveyed", - "terminal", - "side", + "find", + "support", "dichroism", - "spectroscopies" + "turn", + "replacement", + "hypothesized", + "facile" ], "release_date":"2023-05-24", "publication":"\"Macrocyclic beta-Sheets Stabilized by Hydrogen Bond Surrogates\", Angew.Chem.Int.Ed.Engl., 62, e202303943-e202303943", @@ -624522,82 +627076,82 @@ ], "subtitle":"Scaffolding protein functional sites using deep learning", "tags":[ - "scaffolding protein functional sites", "de novo protein", - "deep learning", - "de novo design" + "de novo design", + "scaffolding protein functional sites", + "deep learning" ], "keywords":[ - "predicted", - "sites", - "viable", - "without", - "rosettafold", - "designs", - "overall", - "tests", - "functional", - "network", - "proteins", - "needing", + "design", + "sequences", + "constrained", + "learning", "immunogens", - "use", - "approach", + "additional", + "candidate", + "number", + "methods", + "structures", + "experimental", "hallucination", - "specifically", + "functional", "single", - "enzymes", - "catalytic", "metalloproteins", - "desired", - "optimizes", - "experimental", + "approaches", + "first", + "overall", + "without", + "residues", + "structure", + "specifically", "fold", + "traps", "place", - "trained", - "candidate", - "scaffolding", - "number", - "receptor", - "small", - "residues", - "approaches", "functions", - "prespecify", + "starts", + "protein", + "network", + "approach", + "viable", + "rosettafold", + "proteins", + "sites", + "generally", + "binding", "forward", - "inpainting", - "two", - "methods", + "validate", + "silico", + "use", + "enzymes", + "mediated", "site", - "constrained", - "generally", + "fills", + "needing", "scaffold", - "design", - "sequences", - "structures", - "protein", - "using", + "predicted", + "inpainting", + "small", + "optimizes", + "sequence", + "tests", + "trained", + "scaffolding", + "catalytic", + "contain", + "two", "secondary", - "traps", - "validate", "describe", - "structure", - "pass", - "sequence", + "second", + "desired", + "create", + "designs", "held", + "using", "combination", - "fills", - "silico", - "mediated", - "starts", - "additional", + "prespecify", + "receptor", "deep", - "first", - "learning", - "second", - "binding", - "create", - "contain" + "pass" ], "release_date":"2022-08-10", "publication":"\"Scaffolding protein functional sites using deep learning\", Science, 377, 387-394", @@ -624782,84 +627336,84 @@ ], "subtitle":"Neoleukin 4, a de novo designed il-4 mimetic", "tags":[ - "cytokine", + "designed protein", "de novo protein", - "designed protein" + "cytokine" ], "keywords":[ - "great", - "plays", - "demonstrate", - "sophisticated", - "require", - "animal", - "directly", - "differential", - "critical", - "clinical", + "designed", + "complex", "cytokine", "models", - "pleiotropic", - "recapitulate", - "providing", - "receptors", - "cytokines", - "de", - "homeostasis", - "novo", - "although", - "mimetics", - "contrast", - "signaling", - "scaffolds", - "designed", - "receptor", - "mimetic", - "inaccessible", "engineered", - "denoted", - "interest", - "immune", - "useful", - "functions", - "targeted", - "physiological", - "actions", - "signals", - "biomaterials", - "potential", "limited", - "scaffold", - "based", + "critical", "design", - "type", - "ii", - "interrogating", + "role", + "signaling", + "require", + "insights", + "hyperstable", "exclusively", + "receptors", + "targeted", + "development", + "providing", + "interest", + "recapitulate", + "de", "formats", - "workflow", - "inform", - "complex", - "incorporate", "natural", + "signals", "modulating", - "versus", - "development", - "cellular", - "native", - "harnessing", - "hyperstable", - "insights", + "processing", + "denoted", "computationally", - "broadly", "biology", - "processing", - "heat", + "previously", + "potential", + "based", + "differential", + "great", + "scaffolds", + "inform", + "although", + "clinical", "instability", - "role", "therapeutic", + "functions", + "immune", + "useful", + "plays", + "type", + "mimetic", "hyperstability", - "previously" + "pleiotropic", + "interrogating", + "workflow", + "animal", + "actions", + "cellular", + "contrast", + "sophisticated", + "novo", + "demonstrate", + "native", + "broadly", + "scaffold", + "inaccessible", + "physiological", + "versus", + "biomaterials", + "heat", + "incorporate", + "homeostasis", + "harnessing", + "cytokines", + "receptor", + "mimetics", + "directly", + "ii" ], "release_date":"2023-03-29", "publication":"\"Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds\", Nat.Chem.Biol., 19, 1127-1137", @@ -624963,12 +627517,12 @@ ], "subtitle":"Homotrimeric variant of tctrp9, bgl06", "tags":[ - "computationally designed", - "tandem repeat protein", "designed", - "de novo protein", + "tandem repeat protein", "de novo", - "ctrp" + "de novo protein", + "ctrp", + "computationally designed" ], "keywords":[ "description", @@ -625160,12 +627714,12 @@ ], "subtitle":"Homotrimeric variant of tctrp9, bgl15", "tags":[ - "computationally designed", - "tandem repeat protein", "designed", - "de novo protein", + "tandem repeat protein", "de novo", - "ctrp" + "de novo protein", + "ctrp", + "computationally designed" ], "keywords":[ "description", @@ -625337,12 +627891,12 @@ ], "subtitle":"Homotrimeric variant of tctrp9, bgl18", "tags":[ - "computationally designed", - "tandem repeat protein", "designed", - "de novo protein", + "tandem repeat protein", "de novo", - "ctrp" + "de novo protein", + "ctrp", + "computationally designed" ], "keywords":[ "description", @@ -625534,12 +628088,12 @@ ], "subtitle":"Heterotrimeric variant of tctrp9, hetbgl03-15-18", "tags":[ - "computationally designed", - "tandem repeat protein", "designed", - "de novo protein", + "tandem repeat protein", "de novo", - "ctrp" + "de novo protein", + "ctrp", + "computationally designed" ], "keywords":[ "description", @@ -625575,32 +628129,36 @@ "next_design":"8e12", "seq_thr_sim_designed":[ { - "sim":230.0, - "partner":"8e0m" + "sim":253.0, + "partner":"8e0n" }, { - "sim":165.0, - "partner":"8e12" + "sim":204.0, + "partner":"9dze" }, { - "sim":195.0, - "partner":"6xr2" + "sim":165.0, + "partner":"8e12" }, { "sim":196.0, "partner":"6xr1" }, { - "sim":253.0, - "partner":"8e0n" + "sim":195.0, + "partner":"6xr2" + }, + { + "sim":230.0, + "partner":"8e0m" }, { "sim":143.0, "partner":"8e0l" }, { - "sim":204.0, - "partner":"9dze" + "sim":154.0, + "partner":"8flx" }, { "sim":131.0, @@ -625610,18 +628168,10 @@ "sim":128.0, "partner":"8v2d" }, - { - "sim":154.0, - "partner":"8flx" - }, { "sim":96.0, "partner":"5cwm" }, - { - "sim":72.0, - "partner":"6e9z" - }, { "sim":84.0, "partner":"6e9t" @@ -625630,17 +628180,29 @@ "sim":70.0, "partner":"6e9y" }, + { + "sim":72.0, + "partner":"6e9z" + }, { "sim":65.0, "partner":"6e9v" }, + { + "sim":66.0, + "partner":"5cwq" + }, + { + "sim":57.0, + "partner":"8fbj" + }, { "sim":55.0, "partner":"8fbo" }, { - "sim":66.0, - "partner":"5cwq" + "sim":56.0, + "partner":"8e1e" }, { "sim":61.0, @@ -625658,29 +628220,25 @@ "sim":57.0, "partner":"8g9k" }, - { - "sim":56.0, - "partner":"8e1e" - }, { "sim":56.0, "partner":"8fbi" }, { - "sim":50.0, - "partner":"7udl" + "sim":51.0, + "partner":"8vea" }, { "sim":50.0, - "partner":"7udm" + "partner":"7udl" }, { "sim":50.0, "partner":"7udn" }, { - "sim":57.0, - "partner":"8fbj" + "sim":50.0, + "partner":"7udm" } ], "seq_thr_sim_natural":[ @@ -625747,12 +628305,12 @@ ], "subtitle":"Homotrimeric variant of tctrp9, bgl14", "tags":[ - "computationally designed", - "tandem repeat protein", "designed", - "de novo protein", + "tandem repeat protein", "de novo", - "ctrp" + "de novo protein", + "ctrp", + "computationally designed" ], "keywords":[ "description", @@ -625970,125 +628528,125 @@ "subtitle":"Scaffolding protein functional sites using deep learning", "tags":[ "scaffolding protein", - "ligand binding", - "de novo protein", + "de novo design", "pocket", - "de novo design" + "de novo protein", + "ligand binding" ], "keywords":[ - "axes", + "substrates", "largely", - "constraints", - "dock", "surrounding", - "possibilities", - "scattering", - "close", - "challenge", - "designed", - "84", - "curved", - "crystal", - "expression", - "overcome", - "necessarily", - "8", - "designing", - "structure", - "repeat", - "cryoem", - "monomer", - "rich", - "oligomer", - "2d", - "coming", - "consistent", - "interfaces", - "general", - "built", - "allows", - "incorporation", - "proteins", - "models", - "binder", - "\u00e5", "open", - "small", - "interface", "recognition", - "nature", - "folded", - "glutamine", - "angstroms", - "structures", - "averages", - "pockets", - "solution", - "suitable", - "native", - "47", - "size", - "appropriate", - "form", - "molecules", + "cavities", + "repeat", + "overcome", + "well", + "single", "free", - "35", - "nanocages", - "monomers", - "data", - "substrates", - "associated", - "coli", - "ranging", - "asymmetric", - "class", - "shape", - "may", - "saxs", - "specific", - "cryogenic", - "several", - "design", + "protein", + "readily", + "pockets", + "destabilization", "symmetrically", "helical", - "considerably", - "soluble", - "states", + "electron", + "binding", "across", - "symmetry", + "133", + "microscopy", "synthetase", - "cavities", - "ion", + "together", "suited", - "sites", - "tested", + "close", + "general", + "necessarily", + "crystal", + "correct", + "asymmetric", + "formed", + "2d", + "soluble", + "specific", + "folded", + "20", "approach", "showing", - "destabilization", - "composition", - "single", - "sizes", - "together", - "enable", - "electron", - "well", + "sites", + "proteins", + "size", + "several", + "scattering", + "may", + "constraints", + "binder", + "interface", + "small", + "possibilities", + "axes", "found", - "correct", - "central", - "binding", - "protein", - "microscopy", - "readily", - "arbitrary", + "coming", + "monomer", + "incorporation", "computational", - "20", - "oligomeric", + "35", + "84", + "designing", + "dock", + "angstroms", + "symmetry", + "design", + "averages", "destabilize", + "glutamine", + "tested", + "monomers", + "sizes", + "oligomeric", + "cryogenic", + "rich", + "saxs", + "nanocages", + "appropriate", + "cryoem", + "solution", + "oligomer", "analogous", - "133", + "allows", + "coli", + "states", + "considerably", "developed", - "formed", - "nsem" + "associated", + "designed", + "form", + "central", + "models", + "curved", + "interfaces", + "structures", + "built", + "suitable", + "ranging", + "nsem", + "\u00e5", + "structure", + "shape", + "ion", + "nature", + "class", + "molecules", + "enable", + "native", + "47", + "expression", + "composition", + "data", + "arbitrary", + "challenge", + "8", + "consistent" ], "release_date":"2023-08-16", "publication":"\"Design of Diverse Asymmetric Pockets in De Novo Homo-oligomeric Proteins\", Biochemistry, 62, 358-368", @@ -626258,128 +628816,128 @@ ], "subtitle":"Design of diverse asymmetric pockets in de novo homo-oligomeric proteins", "tags":[ + "pockets", + "de novo design", "tetramer", - "cryoem", + "de novo protein", "rosetta", "oligomer", - "de novo protein", - "pockets", - "de novo design" + "cryoem" ], "keywords":[ - "axes", + "substrates", "largely", - "constraints", - "dock", "surrounding", - "possibilities", - "scattering", - "close", - "challenge", - "designed", - "84", - "curved", - "crystal", - "expression", - "overcome", - "necessarily", - "8", - "designing", - "structure", - "repeat", - "cryoem", - "monomer", - "rich", - "oligomer", - "2d", - "coming", - "consistent", - "interfaces", - "general", - "built", - "allows", - "incorporation", - "proteins", - "models", - "binder", - "\u00e5", "open", - "small", - "interface", "recognition", - "nature", - "folded", - "glutamine", - "angstroms", - "structures", - "averages", - "pockets", - "solution", - "suitable", - "native", - "47", - "size", - "appropriate", - "form", - "molecules", + "cavities", + "repeat", + "overcome", + "well", + "single", "free", - "35", - "nanocages", - "monomers", - "data", - "substrates", - "associated", - "coli", - "ranging", - "asymmetric", - "class", - "shape", - "may", - "saxs", - "specific", - "cryogenic", - "several", - "design", + "protein", + "readily", + "pockets", + "destabilization", "symmetrically", "helical", - "considerably", - "soluble", - "states", + "electron", + "binding", "across", - "symmetry", + "133", + "microscopy", "synthetase", - "cavities", - "ion", + "together", "suited", - "sites", - "tested", + "close", + "general", + "necessarily", + "crystal", + "correct", + "asymmetric", + "formed", + "2d", + "soluble", + "specific", + "folded", + "20", "approach", "showing", - "destabilization", - "composition", - "single", - "sizes", - "together", - "enable", - "electron", - "well", + "sites", + "proteins", + "size", + "several", + "scattering", + "may", + "constraints", + "binder", + "interface", + "small", + "possibilities", + "axes", "found", - "correct", - "central", - "binding", - "protein", - "microscopy", - "readily", - "arbitrary", + "coming", + "monomer", + "incorporation", "computational", - "20", - "oligomeric", + "35", + "84", + "designing", + "dock", + "angstroms", + "symmetry", + "design", + "averages", "destabilize", + "glutamine", + "tested", + "monomers", + "sizes", + "oligomeric", + "cryogenic", + "rich", + "saxs", + "nanocages", + "appropriate", + "cryoem", + "solution", + "oligomer", "analogous", - "133", + "allows", + "coli", + "states", + "considerably", "developed", - "formed", - "nsem" + "associated", + "designed", + "form", + "central", + "models", + "curved", + "interfaces", + "structures", + "built", + "suitable", + "ranging", + "nsem", + "\u00e5", + "structure", + "shape", + "ion", + "nature", + "class", + "molecules", + "enable", + "native", + "47", + "expression", + "composition", + "data", + "arbitrary", + "challenge", + "8", + "consistent" ], "release_date":"2023-01-25", "publication":"\"Design of Diverse Asymmetric Pockets in De Novo Homo-oligomeric Proteins\", Biochemistry, 62, 358-368", @@ -626428,11 +628986,11 @@ }, { "sim":57.0, - "partner":"7udm" + "partner":"7udn" }, { "sim":57.0, - "partner":"7udn" + "partner":"7udm" }, { "sim":55.0, @@ -626567,108 +629125,108 @@ ], "subtitle":"Covalently stabilized triangular trimer derived from abeta16-36 with p-iodo-phenylalanine", "tags":[ - "abeta oligomer", "trimer", - "beta-hairpin", "de novo protein", - "dodecamer", - "alzheimer's disease" + "beta-hairpin", + "abeta oligomer", + "alzheimer's disease", + "dodecamer" ], "keywords":[ - "characteristics", - "oligomers", - "aggregation", - "many", - "propensity", - "adopting", - "studies", - "enter", - "share", + "a\u03b2", "trimer", - "crystallography", - "peptide", + "elucidation", + "disease", + "structural", + "dodecamer", + "differences", + "lead", + "within", + "model", + "working", + "precluded", + "cellular", + "accumulate", + "demonstrate", + "cells", + "greater", + "forms", + "covalently", + "two", + "aggregates", + "effects", "shed", - "provide", + "shows", + "soluble", "alzheimer", - "endocytosis", + "biological", + "aggregation", + "trimers", + "isomorphic", + "derived", + "propensity", + "showing", + "large", "interact", + "share", + "capable", + "endocytosis", + "characterization", "outer", + "described", + "may", + "small", + "adopting", "regions", - "multitude", + "peptide", + "apoptosis", "c", - "conformations", - "disease", - "pathogenesis", - "interaction", - "insoluble", - "elucidation", - "plasma", - "membrane", - "forms", - "a\u03b2", + "activate", + "exhibit", + "enter", + "help", + "different", "compare", - "working", - "paper", - "small", - "covalently", - "assemble", - "lead", - "structures", - "derived", - "markedly", "assembly", - "cellular", - "exhibit", - "effects", - "form", - "shows", "properties", - "activate", - "associated", - "reveals", - "large", - "precluded", - "detailed", - "among", - "progression", - "trimers", - "may", - "closely", - "help", - "model", - "characterization", - "soluble", - "stabilized", - "biological", - "indicate", - "cells", - "greater", - "aggregates", - "structural", - "demonstrate", - "one", - "dodecamer", + "markedly", "also", - "showing", - "described", - "isomorphic", + "light", + "multitude", "fibrils", - "different", - "capable", - "two", + "interaction", + "homogeneous", + "elicit", + "varying", + "insoluble", + "reveals", + "mechanism", + "associated", + "characteristics", "folds", + "form", "central", - "light", - "mechanism", + "many", + "one", + "indicate", + "structures", + "oligomers", + "detailed", + "plasma", + "among", + "provide", + "closely", + "crystallography", + "biophysical", + "membrane", "toxicity", - "differences", - "elicit", - "homogeneous", - "within", - "accumulate", - "apoptosis", - "varying", - "biophysical" + "progression", + "conformations", + "studies", + "assemble", + "pathogenesis", + "stabilized", + "paper" ], "release_date":"2023-05-31", "publication":"\"Probing differences among A beta oligomers with two triangular trimers derived from A beta\", Proc.Natl.Acad.Sci.USA, 120, e2219216120-e2219216120", @@ -626811,108 +629369,108 @@ ], "subtitle":"Covalently stabilized triangular trimer derived from abeta16-36", "tags":[ - "abeta oligomer", "trimer", - "beta-hairpin", "de novo protein", - "dodecamer", - "alzheimer's disease" + "beta-hairpin", + "abeta oligomer", + "alzheimer's disease", + "dodecamer" ], "keywords":[ - "characteristics", - "oligomers", - "aggregation", - "many", - "propensity", - "adopting", - "studies", - "enter", - "share", + "a\u03b2", "trimer", - "crystallography", - "peptide", + "elucidation", + "disease", + "structural", + "dodecamer", + "differences", + "lead", + "within", + "model", + "working", + "precluded", + "cellular", + "accumulate", + "demonstrate", + "cells", + "greater", + "forms", + "covalently", + "two", + "aggregates", + "effects", "shed", - "provide", + "shows", + "soluble", "alzheimer", - "endocytosis", + "biological", + "aggregation", + "trimers", + "isomorphic", + "derived", + "propensity", + "showing", + "large", "interact", + "share", + "capable", + "endocytosis", + "characterization", "outer", + "described", + "may", + "small", + "adopting", "regions", - "multitude", + "peptide", + "apoptosis", "c", - "conformations", - "disease", - "pathogenesis", - "interaction", - "insoluble", - "elucidation", - "plasma", - "membrane", - "forms", - "a\u03b2", + "activate", + "exhibit", + "enter", + "help", + "different", "compare", - "working", - "paper", - "small", - "covalently", - "assemble", - "lead", - "structures", - "derived", - "markedly", "assembly", - "cellular", - "exhibit", - "effects", - "form", - "shows", "properties", - "activate", - "associated", - "reveals", - "large", - "precluded", - "detailed", - "among", - "progression", - "trimers", - "may", - "closely", - "help", - "model", - "characterization", - "soluble", - "stabilized", - "biological", - "indicate", - "cells", - "greater", - "aggregates", - "structural", - "demonstrate", - "one", - "dodecamer", + "markedly", "also", - "showing", - "described", - "isomorphic", + "light", + "multitude", "fibrils", - "different", - "capable", - "two", + "interaction", + "homogeneous", + "elicit", + "varying", + "insoluble", + "reveals", + "mechanism", + "associated", + "characteristics", "folds", + "form", "central", - "light", - "mechanism", + "many", + "one", + "indicate", + "structures", + "oligomers", + "detailed", + "plasma", + "among", + "provide", + "closely", + "crystallography", + "biophysical", + "membrane", "toxicity", - "differences", - "elicit", - "homogeneous", - "within", - "accumulate", - "apoptosis", - "varying", - "biophysical" + "progression", + "conformations", + "studies", + "assemble", + "pathogenesis", + "stabilized", + "paper" ], "release_date":"2023-05-31", "publication":"\"Probing differences among A beta oligomers with two triangular trimers derived from A beta\", Proc.Natl.Acad.Sci.USA, 120, e2219216120-e2219216120", @@ -627004,11 +629562,11 @@ ], "subtitle":"Computational design of potent and selective inhibitors of bak and bax", "tags":[ - "bax", - "selective inhibitors", "computational design", + "de novo protein", "bak", - "de novo protein" + "selective inhibitors", + "bax" ], "keywords":[ "description", @@ -627160,79 +629718,79 @@ ], "subtitle":"De novo designed ice-binding proteins from twist-constrained helices", "tags":[ - "ice-binding proteins", "de novo protein", - "de novo designed" + "de novo designed", + "ice-binding proteins" ], "keywords":[ - "series", - "constraining", - "twist", - "control", - "solidification", + "winter", + "designed", + "designing", + "aspect", + "engineering", + "shed", + "design", "poorly", - "align", - "proteins", - "helices", - "hypothesized", - "thus", - "putative", - "ice", - "exactly", - "reverse", - "de", - "novo", "bundles", - "threonines", "opening", - "hypothesis", - "winter", - "test", - "shed", - "designed", + "ibps", + "direction", + "show", + "validating", + "threonines", + "de", "undertwisting", + "putative", "processes", - "residues", - "uses", - "science", - "understood", - "degree", + "ice", + "thus", + "align", "antifreeze", + "residues", "straight", - "two", - "materials", - "avenues", - "engineering", - "inhibition", - "light", - "show", - "relationships", - "attaining", - "design", - "model", - "direction", + "constraining", + "helix", + "crucial", + "solidification", + "increases", + "projecting", "findings", + "model", + "bewildering", + "control", + "propose", + "relationships", "protein", + "light", + "proteins", + "avenues", + "formation", + "understood", + "reverse", + "series", + "degree", "arrays", - "using", - "propose", - "designing", - "projecting", - "helix", + "novo", + "twist", + "test", + "uses", + "flounder", + "attaining", + "two", + "inhibition", + "threonine", + "supporting", + "organisms", + "helices", + "materials", "unusual", - "validating", "evolved", - "ibps", "computational", - "formation", - "organisms", - "aspect", - "bewildering", - "flounder", - "crucial", - "increases", - "supporting", - "threonine" + "hypothesis", + "using", + "exactly", + "hypothesized", + "science" ], "release_date":"2023-07-12", "publication":"\"De novo designed ice-binding proteins from twist-constrained helices\", Proc.Natl.Acad.Sci.USA, 120, e2220380120-e2220380120", @@ -627378,78 +629936,78 @@ "subtitle":"Precisely patterned nanofibers made from extendable protein multiplexes", "tags":[ "de novo protein", - "nanofibers", - "de novo design" + "de novo design", + "nanofibers" ], "keywords":[ - "axes", - "monomers", - "coiled", - "generating", - "architectures", - "demonstrate", - "considerable", - "staggering", - "oligomers", + "relatively", + "superhelical", + "c", + "fibres", + "flexibility", + "designed", + "surface", "molecular", - "coincident", - "proteins", - "shortened", - "placement", - "geometry", - "approach", - "extended", - "systematically", - "wide", + "symmetry", + "design", + "limited", + "protomers", + "introducing", + "patches", "length", - "fixed", - "extendable", - "among", - "designed", + "geometry", + "repeat", "number", - "modular", + "unbounded", + "tuned", + "fixed", "lengthened", - "changing", + "oligomers", + "systematically", + "constituent", + "coincident", + "monomers", + "extendable", + "extended", "rigid", - "flexibility", + "among", + "hydrophilic", "precisely", - "materials", - "symmetric", - "constituent", - "limited", - "systematic", - "blocks", - "tuned", - "propagation", - "design", - "units", - "helical", - "superhelical", + "cyclic", + "changing", "protein", - "8", - "2", - "protomers", - "coils", - "symmetry", - "describe", - "c", - "relatively", "readily", - "repeat", - "surface", - "patches", + "architectures", + "propagation", + "wide", + "approach", + "blocks", + "proteins", + "helical", + "symmetric", + "shortened", "force", + "systematic", "varying", - "hydrophilic", - "monomer", - "introducing", - "fibres", + "coiled", + "considerable", + "modular", + "2", + "units", + "demonstrate", + "advantages", "building", - "unbounded", "systems", - "advantages", - "cyclic", - "range" + "axes", + "generating", + "coils", + "describe", + "range", + "monomer", + "materials", + "placement", + "8", + "staggering" ], "release_date":"2023-08-16", "publication":"\"Precisely patterned nanofibres made from extendable protein multiplexes\", Nat.Chem., 15, 1664-1671", @@ -627595,78 +630153,78 @@ "subtitle":"Precisely patterned nanofibers made from extendable protein multiplexes", "tags":[ "de novo protein", - "nanofibers", - "de novo design" + "de novo design", + "nanofibers" ], "keywords":[ - "axes", - "monomers", - "coiled", - "generating", - "architectures", - "demonstrate", - "considerable", - "staggering", - "oligomers", + "relatively", + "superhelical", + "c", + "fibres", + "flexibility", + "designed", + "surface", "molecular", - "coincident", - "proteins", - "shortened", - "placement", - "geometry", - "approach", - "extended", - "systematically", - "wide", + "symmetry", + "design", + "limited", + "protomers", + "introducing", + "patches", "length", - "fixed", - "extendable", - "among", - "designed", + "geometry", + "repeat", "number", - "modular", + "unbounded", + "tuned", + "fixed", "lengthened", - "changing", + "oligomers", + "systematically", + "constituent", + "coincident", + "monomers", + "extendable", + "extended", "rigid", - "flexibility", + "among", + "hydrophilic", "precisely", - "materials", - "symmetric", - "constituent", - "limited", - "systematic", - "blocks", - "tuned", - "propagation", - "design", - "units", - "helical", - "superhelical", + "cyclic", + "changing", "protein", - "8", - "2", - "protomers", - "coils", - "symmetry", - "describe", - "c", - "relatively", "readily", - "repeat", - "surface", - "patches", + "architectures", + "propagation", + "wide", + "approach", + "blocks", + "proteins", + "helical", + "symmetric", + "shortened", "force", + "systematic", "varying", - "hydrophilic", - "monomer", - "introducing", - "fibres", + "coiled", + "considerable", + "modular", + "2", + "units", + "demonstrate", + "advantages", "building", - "unbounded", "systems", - "advantages", - "cyclic", - "range" + "axes", + "generating", + "coils", + "describe", + "range", + "monomer", + "materials", + "placement", + "8", + "staggering" ], "release_date":"2023-08-16", "publication":"\"Precisely patterned nanofibres made from extendable protein multiplexes\", Nat.Chem., 15, 1664-1671", @@ -627820,78 +630378,78 @@ "subtitle":"Precisely patterned nanofibers made from extendable protein multiplexes", "tags":[ "de novo protein", - "nanofibers", - "de novo design" + "de novo design", + "nanofibers" ], "keywords":[ - "axes", - "monomers", - "coiled", - "generating", - "architectures", - "demonstrate", - "considerable", - "staggering", - "oligomers", + "relatively", + "superhelical", + "c", + "fibres", + "flexibility", + "designed", + "surface", "molecular", - "coincident", - "proteins", - "shortened", - "placement", - "geometry", - "approach", - "extended", - "systematically", - "wide", + "symmetry", + "design", + "limited", + "protomers", + "introducing", + "patches", "length", - "fixed", - "extendable", - "among", - "designed", + "geometry", + "repeat", "number", - "modular", + "unbounded", + "tuned", + "fixed", "lengthened", - "changing", + "oligomers", + "systematically", + "constituent", + "coincident", + "monomers", + "extendable", + "extended", "rigid", - "flexibility", + "among", + "hydrophilic", "precisely", - "materials", - "symmetric", - "constituent", - "limited", - "systematic", - "blocks", - "tuned", - "propagation", - "design", - "units", - "helical", - "superhelical", + "cyclic", + "changing", "protein", - "8", - "2", - "protomers", - "coils", - "symmetry", - "describe", - "c", - "relatively", "readily", - "repeat", - "surface", - "patches", + "architectures", + "propagation", + "wide", + "approach", + "blocks", + "proteins", + "helical", + "symmetric", + "shortened", "force", + "systematic", "varying", - "hydrophilic", - "monomer", - "introducing", - "fibres", + "coiled", + "considerable", + "modular", + "2", + "units", + "demonstrate", + "advantages", "building", - "unbounded", "systems", - "advantages", - "cyclic", - "range" + "axes", + "generating", + "coils", + "describe", + "range", + "monomer", + "materials", + "placement", + "8", + "staggering" ], "release_date":"2023-08-16", "publication":"\"Precisely patterned nanofibres made from extendable protein multiplexes\", Nat.Chem., 15, 1664-1671", @@ -628041,78 +630599,78 @@ "subtitle":"Precisely patterned nanofibers made from extendable protein multiplexes", "tags":[ "de novo protein", - "nanofibers", - "de novo design" + "de novo design", + "nanofibers" ], "keywords":[ - "axes", - "monomers", - "coiled", - "generating", - "architectures", - "demonstrate", - "considerable", - "staggering", - "oligomers", + "relatively", + "superhelical", + "c", + "fibres", + "flexibility", + "designed", + "surface", "molecular", - "coincident", - "proteins", - "shortened", - "placement", - "geometry", - "approach", - "extended", - "systematically", - "wide", + "symmetry", + "design", + "limited", + "protomers", + "introducing", + "patches", "length", - "fixed", - "extendable", - "among", - "designed", + "geometry", + "repeat", "number", - "modular", + "unbounded", + "tuned", + "fixed", "lengthened", - "changing", + "oligomers", + "systematically", + "constituent", + "coincident", + "monomers", + "extendable", + "extended", "rigid", - "flexibility", + "among", + "hydrophilic", "precisely", - "materials", - "symmetric", - "constituent", - "limited", - "systematic", - "blocks", - "tuned", - "propagation", - "design", - "units", - "helical", - "superhelical", + "cyclic", + "changing", "protein", - "8", - "2", - "protomers", - "coils", - "symmetry", - "describe", - "c", - "relatively", "readily", - "repeat", - "surface", - "patches", + "architectures", + "propagation", + "wide", + "approach", + "blocks", + "proteins", + "helical", + "symmetric", + "shortened", "force", + "systematic", "varying", - "hydrophilic", - "monomer", - "introducing", - "fibres", + "coiled", + "considerable", + "modular", + "2", + "units", + "demonstrate", + "advantages", "building", - "unbounded", "systems", - "advantages", - "cyclic", - "range" + "axes", + "generating", + "coils", + "describe", + "range", + "monomer", + "materials", + "placement", + "8", + "staggering" ], "release_date":"2023-08-23", "publication":"\"Precisely patterned nanofibres made from extendable protein multiplexes\", Nat.Chem., 15, 1664-1671", @@ -628233,96 +630791,96 @@ ], "subtitle":"Designed pentafoil knot protein folded into a trefoil knot", "tags":[ + "de novo", "pentafoil", - "trefoil", - "knot", "de novo protein", - "de novo" + "trefoil", + "knot" ], "keywords":[ - "compatibility", + "repeats", "largely", + "ray", + "whose", + "insights", + "interesting", + "repeat", + "methods", + "knotted", + "extended", "results", - "thus", - "misfolded", - "crystallography", + "folding", + "protein", + "topologies", + "5", + "focus", + "x", + "confirmed", + "novo", "test", - "designed", - "provide", - "local", - "pathways", - "methods", - "order", - "sequences", + "two", + "misfolded", + "asymmetric", "conformation", - "represent", - "structure", - "repeat", - "insights", - "intended", "backbones", + "algorithms", + "thus", + "pentafoil", + "matched", + "intended", + "case", "contacts", - "without", - "5", - "topology", + "stability", "proteins", - "de", - "focus", - "knotted", - "seen", - "yet", - "consideration", - "nature", - "symmetric", - "3", - "pentafoil", + "described", + "tandem", + "may", "units", - "whose", - "attempts", + "compatibility", + "diverged", "construct", - "matching", - "trefoil", - "form", - "previously", - "stability", - "substantial", - "report", - "extended", - "asymmetric", "four", - "topologies", + "pathways", + "substantial", "1", - "may", - "tandem", - "interesting", - "diverged", + "local", "design", - "rather", - "introduce", - "explicit", - "sequence", - "repeats", - "ray", - "optimizing", - "despite", - "also", - "n", - "described", - "novo", + "topology", + "represent", + "yet", "behaviour", - "matched", - "confirmed", - "two", - "folds", - "barriers", + "n", + "also", + "seen", + "consideration", + "symmetric", "leading", - "protein", + "matching", "backbone", - "algorithms", + "sequence", + "folds", + "explicit", "deeply", - "x", - "case", - "folding", + "designed", + "form", + "order", + "sequences", + "rather", + "trefoil", + "de", + "3", + "attempts", + "previously", + "without", + "optimizing", + "structure", + "introduce", + "report", + "provide", + "crystallography", + "nature", + "barriers", + "despite", "create" ], "release_date":"2023-10-25", @@ -628380,10 +630938,6 @@ "sim":56.0, "partner":"2zny" }, - { - "sim":56.0, - "partner":"8wlb" - }, { "sim":56.0, "partner":"8wl5" @@ -628396,6 +630950,10 @@ "sim":56.0, "partner":"8wl9" }, + { + "sim":56.0, + "partner":"8wlb" + }, { "sim":52.0, "partner":"4u1p" @@ -628424,10 +630982,6 @@ "sim":52.0, "partner":"5c12" }, - { - "sim":52.0, - "partner":"3c1y" - }, { "sim":52.0, "partner":"3c1z" @@ -628452,6 +631006,10 @@ "sim":52.0, "partner":"4yxm" }, + { + "sim":52.0, + "partner":"3c1y" + }, { "sim":52.0, "partner":"3tai" @@ -628468,10 +631026,6 @@ "sim":51.0, "partner":"1te4" }, - { - "sim":51.0, - "partner":"3rg6" - }, { "sim":51.0, "partner":"2wvw" @@ -628484,6 +631038,10 @@ "sim":51.0, "partner":"2peo" }, + { + "sim":51.0, + "partner":"3rg6" + }, { "sim":51.0, "partner":"4hu3" @@ -628516,21 +631074,17 @@ "sim":51.0, "partner":"3mco" }, - { - "sim":51.0, - "partner":"6ak4" - }, { "sim":51.0, "partner":"6aej" }, { "sim":51.0, - "partner":"6akw" + "partner":"6ak4" }, { "sim":51.0, - "partner":"4ie7" + "partner":"6akw" }, { "sim":51.0, @@ -628550,15 +631104,15 @@ }, { "sim":51.0, - "partner":"4idz" + "partner":"7e8z" }, { "sim":51.0, - "partner":"4ie0" + "partner":"4idz" }, { "sim":51.0, - "partner":"7e8z" + "partner":"4ie0" }, { "sim":51.0, @@ -628576,6 +631130,10 @@ "sim":51.0, "partner":"4qho" }, + { + "sim":51.0, + "partner":"4ie7" + }, { "sim":51.0, "partner":"6d23" @@ -628598,15 +631156,15 @@ }, { "sim":51.0, - "partner":"5tsh" + "partner":"6olj" }, { "sim":51.0, - "partner":"6olj" + "partner":"5tsg" }, { "sim":51.0, - "partner":"5tsg" + "partner":"5tsh" }, { "sim":51.0, @@ -628636,10 +631194,6 @@ "sim":50.0, "partner":"1kft" }, - { - "sim":50.0, - "partner":"1zw3" - }, { "sim":50.0, "partner":"1zvz" @@ -628650,12 +631204,16 @@ }, { "sim":50.0, - "partner":"5y2o" + "partner":"1zw3" }, { "sim":50.0, "partner":"5y2t" }, + { + "sim":50.0, + "partner":"5y2o" + }, { "sim":50.0, "partner":"4txc" @@ -628688,10 +631246,6 @@ "sim":50.0, "partner":"2i4o" }, - { - "sim":50.0, - "partner":"5v1s" - }, { "sim":50.0, "partner":"5v1t" @@ -628702,7 +631256,7 @@ }, { "sim":50.0, - "partner":"4dqw" + "partner":"5v1s" }, { "sim":50.0, @@ -628712,6 +631266,10 @@ "sim":50.0, "partner":"6gk9" }, + { + "sim":50.0, + "partner":"4dqw" + }, { "sim":50.0, "partner":"6nr7" @@ -628779,10 +631337,10 @@ ], "subtitle":"Ancestral petase 55_547", "tags":[ - "petase", "pet", - "hydrolase", "plastic degradation", + "petase", + "hydrolase", "ancestral sequence reconstruction" ], "keywords":[ @@ -628852,11 +631410,11 @@ }, { "sim":51.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":51.0, - "partner":"8w08" + "partner":"8v0a" }, { "sim":50.0, @@ -628872,11 +631430,11 @@ }, { "sim":50.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":50.0, - "partner":"8w05" + "partner":"8w06" } ], "seq_thr_sim_natural":[ @@ -628918,11 +631476,11 @@ }, { "sim":414.0, - "partner":"7xtu" + "partner":"7xtv" }, { "sim":414.0, - "partner":"7xtv" + "partner":"7xtu" }, { "sim":414.0, @@ -628966,20 +631524,16 @@ }, { "sim":392.0, - "partner":"7e31" + "partner":"7w69" }, { "sim":392.0, - "partner":"7w69" + "partner":"7e31" }, { "sim":392.0, "partner":"7w66" }, - { - "sim":391.0, - "partner":"7e30" - }, { "sim":391.0, "partner":"7cuv" @@ -628992,6 +631546,10 @@ "sim":391.0, "partner":"7w6o" }, + { + "sim":391.0, + "partner":"7e30" + }, { "sim":391.0, "partner":"7w6q" @@ -629042,15 +631600,15 @@ }, { "sim":377.0, - "partner":"7cts" + "partner":"8ibl" }, { "sim":377.0, - "partner":"8ibl" + "partner":"8ibm" }, { "sim":377.0, - "partner":"8ibm" + "partner":"7cts" }, { "sim":377.0, @@ -629154,19 +631712,19 @@ }, { "sim":304.0, - "partner":"8h5l" + "partner":"5xjh" }, { "sim":304.0, - "partner":"6kuq" + "partner":"6kuo" }, { "sim":304.0, - "partner":"5xjh" + "partner":"8h5l" }, { "sim":304.0, - "partner":"6kuo" + "partner":"6kuq" }, { "sim":304.0, @@ -629298,23 +631856,23 @@ }, { "sim":273.0, - "partner":"6eqd" + "partner":"6eqg" }, { "sim":273.0, - "partner":"6eqe" + "partner":"6eqh" }, { "sim":273.0, - "partner":"6eqf" + "partner":"6eqd" }, { "sim":273.0, - "partner":"6eqg" + "partner":"6eqe" }, { "sim":273.0, - "partner":"6eqh" + "partner":"6eqf" }, { "sim":271.0, @@ -629376,6 +631934,26 @@ "sim":250.0, "partner":"8spk" }, + { + "sim":246.0, + "partner":"8ytu" + }, + { + "sim":244.0, + "partner":"8ytv" + }, + { + "sim":227.0, + "partner":"8yty" + }, + { + "sim":225.0, + "partner":"8ytw" + }, + { + "sim":221.0, + "partner":"8ytz" + }, { "sim":143.0, "partner":"7pzj" @@ -629388,10 +631966,6 @@ "sim":72.0, "partner":"2fx5" }, - { - "sim":64.0, - "partner":"4ke6" - }, { "sim":64.0, "partner":"4ke7" @@ -629412,6 +631986,10 @@ "sim":64.0, "partner":"3rli" }, + { + "sim":64.0, + "partner":"4ke6" + }, { "sim":61.0, "partner":"4ke9" @@ -629488,10 +632066,6 @@ "sim":57.0, "partner":"7p1o" }, - { - "sim":57.0, - "partner":"4lre" - }, { "sim":57.0, "partner":"4lrf" @@ -629524,6 +632098,10 @@ "sim":57.0, "partner":"4lrd" }, + { + "sim":57.0, + "partner":"4lre" + }, { "sim":57.0, "partner":"6hr5" @@ -629558,11 +632136,11 @@ }, { "sim":55.0, - "partner":"3kwe" + "partner":"3kwd" }, { "sim":55.0, - "partner":"3kwd" + "partner":"3kwe" }, { "sim":55.0, @@ -629578,51 +632156,51 @@ }, { "sim":55.0, - "partner":"7q2b" + "partner":"7q2f" }, { "sim":55.0, - "partner":"3ha3" + "partner":"7q2g" }, { "sim":55.0, - "partner":"7q2c" + "partner":"7q2h" }, { "sim":55.0, - "partner":"7q2d" + "partner":"3ha5" }, { "sim":55.0, - "partner":"7q2e" + "partner":"2fk7" }, { "sim":55.0, - "partner":"7q2f" + "partner":"2fk8" }, { "sim":55.0, - "partner":"7q2g" + "partner":"3ha7" }, { "sim":55.0, - "partner":"7q2h" + "partner":"7q2b" }, { "sim":55.0, - "partner":"3ha5" + "partner":"7q2c" }, { "sim":55.0, - "partner":"2fk7" + "partner":"3ha3" }, { "sim":55.0, - "partner":"2fk8" + "partner":"7q2d" }, { "sim":55.0, - "partner":"3ha7" + "partner":"7q2e" }, { "sim":55.0, @@ -629654,15 +632232,15 @@ }, { "sim":55.0, - "partner":"7w1c" + "partner":"7w1d" }, { "sim":55.0, - "partner":"7w1d" + "partner":"7w1e" }, { "sim":55.0, - "partner":"7w1e" + "partner":"7w1c" }, { "sim":55.0, @@ -629706,11 +632284,11 @@ }, { "sim":54.0, - "partner":"7xtl" + "partner":"8hlg" }, { "sim":54.0, - "partner":"8hlg" + "partner":"7xtl" }, { "sim":54.0, @@ -629730,23 +632308,23 @@ }, { "sim":54.0, - "partner":"6ub4" + "partner":"6ub2" }, { "sim":54.0, - "partner":"6ub5" + "partner":"6ub3" }, { "sim":54.0, - "partner":"6ub6" + "partner":"6ub4" }, { "sim":54.0, - "partner":"6ub2" + "partner":"6ub5" }, { "sim":54.0, - "partner":"6ub3" + "partner":"6ub6" }, { "sim":54.0, @@ -629792,14 +632370,6 @@ "sim":54.0, "partner":"4n57" }, - { - "sim":54.0, - "partner":"2nq6" - }, - { - "sim":54.0, - "partner":"2nq7" - }, { "sim":54.0, "partner":"2b3k" @@ -629842,11 +632412,15 @@ }, { "sim":54.0, - "partner":"4xq6" + "partner":"2nq6" }, { "sim":54.0, - "partner":"2o0h" + "partner":"2nq7" + }, + { + "sim":54.0, + "partner":"4xq6" }, { "sim":54.0, @@ -629858,19 +632432,19 @@ }, { "sim":54.0, - "partner":"2o1b" + "partner":"2o0h" }, { "sim":54.0, - "partner":"4bko" + "partner":"2o1b" }, { "sim":54.0, - "partner":"5xpj" + "partner":"4bko" }, { "sim":54.0, - "partner":"5dvi" + "partner":"5xpj" }, { "sim":54.0, @@ -629882,7 +632456,7 @@ }, { "sim":54.0, - "partner":"4tm4" + "partner":"5dvi" }, { "sim":54.0, @@ -629904,6 +632478,10 @@ "sim":54.0, "partner":"4tm3" }, + { + "sim":54.0, + "partner":"4tm4" + }, { "sim":54.0, "partner":"4eip" @@ -629938,15 +632516,15 @@ }, { "sim":54.0, - "partner":"6tsh" + "partner":"6tsk" }, { "sim":54.0, - "partner":"6tte" + "partner":"6tsh" }, { "sim":54.0, - "partner":"6tsk" + "partner":"6tte" }, { "sim":54.0, @@ -629968,10 +632546,6 @@ "sim":53.0, "partner":"7vxr" }, - { - "sim":53.0, - "partner":"6ebc" - }, { "sim":53.0, "partner":"6ebd" @@ -629984,6 +632558,10 @@ "sim":53.0, "partner":"6eb4" }, + { + "sim":53.0, + "partner":"6ebc" + }, { "sim":53.0, "partner":"2w1q" @@ -630010,15 +632588,11 @@ }, { "sim":53.0, - "partner":"6pj9" - }, - { - "sim":53.0, - "partner":"6pja" + "partner":"6pjp" }, { "sim":53.0, - "partner":"6pjp" + "partner":"6pjq" }, { "sim":53.0, @@ -630026,11 +632600,11 @@ }, { "sim":53.0, - "partner":"6pjq" + "partner":"6pjr" }, { "sim":53.0, - "partner":"6pjr" + "partner":"6pju" }, { "sim":53.0, @@ -630040,10 +632614,6 @@ "sim":53.0, "partner":"5f5d" }, - { - "sim":53.0, - "partner":"6pju" - }, { "sim":53.0, "partner":"4njp" @@ -630066,15 +632636,19 @@ }, { "sim":53.0, - "partner":"5f5j" + "partner":"6pj5" }, { "sim":53.0, - "partner":"6pj5" + "partner":"6pj7" }, { "sim":53.0, - "partner":"6pj7" + "partner":"5f5j" + }, + { + "sim":53.0, + "partner":"6pj8" }, { "sim":53.0, @@ -630082,7 +632656,11 @@ }, { "sim":53.0, - "partner":"6pj8" + "partner":"6pj9" + }, + { + "sim":53.0, + "partner":"6pja" }, { "sim":53.0, @@ -630102,11 +632680,11 @@ }, { "sim":53.0, - "partner":"6ey1" + "partner":"6f0w" }, { "sim":53.0, - "partner":"6f0w" + "partner":"6ey1" }, { "sim":53.0, @@ -630132,10 +632710,6 @@ "sim":53.0, "partner":"5hk8" }, - { - "sim":53.0, - "partner":"4pgc" - }, { "sim":53.0, "partner":"4pgd" @@ -630154,7 +632728,7 @@ }, { "sim":53.0, - "partner":"3s3h" + "partner":"4pgc" }, { "sim":53.0, @@ -630168,6 +632742,10 @@ "sim":53.0, "partner":"3s3f" }, + { + "sim":53.0, + "partner":"3s3h" + }, { "sim":53.0, "partner":"7k67" @@ -630224,10 +632802,6 @@ "sim":53.0, "partner":"3t8b" }, - { - "sim":53.0, - "partner":"7ajm" - }, { "sim":53.0, "partner":"7a4r" @@ -630242,23 +632816,7 @@ }, { "sim":53.0, - "partner":"7a53" - }, - { - "sim":53.0, - "partner":"7ajw" - }, - { - "sim":53.0, - "partner":"7akb" - }, - { - "sim":53.0, - "partner":"7ajy" - }, - { - "sim":53.0, - "partner":"7a5l" + "partner":"7ajm" }, { "sim":53.0, @@ -630320,10 +632878,30 @@ "sim":53.0, "partner":"7aka" }, + { + "sim":53.0, + "partner":"7a53" + }, { "sim":53.0, "partner":"7akl" }, + { + "sim":53.0, + "partner":"7ajw" + }, + { + "sim":53.0, + "partner":"7akb" + }, + { + "sim":53.0, + "partner":"7ajy" + }, + { + "sim":53.0, + "partner":"7a5l" + }, { "sim":53.0, "partner":"3wcg" @@ -630388,10 +632966,6 @@ "sim":53.0, "partner":"6uug" }, - { - "sim":53.0, - "partner":"5cu7" - }, { "sim":53.0, "partner":"4fdt" @@ -630404,6 +632978,10 @@ "sim":53.0, "partner":"5cx4" }, + { + "sim":53.0, + "partner":"5cu7" + }, { "sim":53.0, "partner":"6rgv" @@ -630600,10 +633178,6 @@ "sim":53.0, "partner":"5x7h" }, - { - "sim":53.0, - "partner":"5y1h" - }, { "sim":53.0, "partner":"5y1k" @@ -630648,6 +633222,10 @@ "sim":53.0, "partner":"5y3i" }, + { + "sim":53.0, + "partner":"5y1h" + }, { "sim":53.0, "partner":"6i60" @@ -630722,11 +633300,11 @@ }, { "sim":52.0, - "partner":"1wc6" + "partner":"1wc1" }, { "sim":52.0, - "partner":"1wc1" + "partner":"1wc6" }, { "sim":52.0, @@ -630742,16 +633320,12 @@ }, { "sim":52.0, - "partner":"7o2t" + "partner":"6z17" }, { "sim":52.0, "partner":"7o2u" }, - { - "sim":52.0, - "partner":"6z17" - }, { "sim":52.0, "partner":"6yz3" @@ -630768,6 +633342,10 @@ "sim":52.0, "partner":"6z5k" }, + { + "sim":52.0, + "partner":"7o2t" + }, { "sim":52.0, "partner":"1zw9" @@ -630834,11 +633412,11 @@ }, { "sim":52.0, - "partner":"1z5z" + "partner":"4gnj" }, { "sim":52.0, - "partner":"4gnj" + "partner":"1z5z" }, { "sim":52.0, @@ -630850,11 +633428,11 @@ }, { "sim":52.0, - "partner":"6hxo" + "partner":"6hxn" }, { "sim":52.0, - "partner":"6hxn" + "partner":"6hxo" }, { "sim":52.0, @@ -630902,11 +633480,11 @@ }, { "sim":52.0, - "partner":"7btm" + "partner":"7bsx" }, { "sim":52.0, - "partner":"7bsx" + "partner":"7btm" }, { "sim":52.0, @@ -630922,19 +633500,19 @@ }, { "sim":52.0, - "partner":"7q4u" + "partner":"7zf2" }, { "sim":52.0, - "partner":"7q59" + "partner":"7q4u" }, { "sim":52.0, - "partner":"7pp4" + "partner":"7q59" }, { "sim":52.0, - "partner":"7zf2" + "partner":"7pp4" }, { "sim":52.0, @@ -630994,55 +633572,55 @@ }, { "sim":52.0, - "partner":"4g2f" + "partner":"3dzq" }, { "sim":52.0, - "partner":"4gk3" + "partner":"4p5z" }, { "sim":52.0, - "partner":"4gk4" + "partner":"4twn" }, { "sim":52.0, - "partner":"4p5q" + "partner":"4two" }, { "sim":52.0, - "partner":"3dzq" + "partner":"4p4c" }, { "sim":52.0, - "partner":"4p5z" + "partner":"4gk2" }, { "sim":52.0, - "partner":"4twn" + "partner":"4g2f" }, { "sim":52.0, - "partner":"4two" + "partner":"4gk3" }, { "sim":52.0, - "partner":"4p4c" + "partner":"4gk4" }, { "sim":52.0, - "partner":"4gk2" + "partner":"4p5q" }, { "sim":52.0, - "partner":"5eeg" + "partner":"5eeh" }, { "sim":52.0, - "partner":"5jr3" + "partner":"5eeg" }, { "sim":52.0, - "partner":"5eeh" + "partner":"5jr3" }, { "sim":52.0, @@ -631138,27 +633716,27 @@ }, { "sim":52.0, - "partner":"6ry0" + "partner":"6ry5" }, { "sim":52.0, - "partner":"6ry1" + "partner":"6ry6" }, { "sim":52.0, - "partner":"6ry2" + "partner":"6ry7" }, { "sim":52.0, - "partner":"6ry5" + "partner":"6ry0" }, { "sim":52.0, - "partner":"6ry6" + "partner":"6ry1" }, { "sim":52.0, - "partner":"6ry7" + "partner":"6ry2" }, { "sim":52.0, @@ -631168,17 +633746,13 @@ "sim":52.0, "partner":"5h9y" }, - { - "sim":52.0, - "partner":"8il0" - }, { "sim":52.0, "partner":"8ila" }, { "sim":52.0, - "partner":"4acg" + "partner":"8il0" }, { "sim":52.0, @@ -631194,15 +633768,15 @@ }, { "sim":52.0, - "partner":"3hzz" + "partner":"4acg" }, { "sim":52.0, - "partner":"2fwr" + "partner":"3hzz" }, { "sim":52.0, - "partner":"2cj9" + "partner":"2fwr" }, { "sim":52.0, @@ -631216,6 +633790,10 @@ "sim":52.0, "partner":"2cjb" }, + { + "sim":52.0, + "partner":"2cj9" + }, { "sim":52.0, "partner":"6yyh" @@ -631248,10 +633826,6 @@ "sim":52.0, "partner":"4l3a" }, - { - "sim":52.0, - "partner":"2fw3" - }, { "sim":52.0, "partner":"4ep9" @@ -631272,6 +633846,10 @@ "sim":52.0, "partner":"4eph" }, + { + "sim":52.0, + "partner":"2fw3" + }, { "sim":52.0, "partner":"2ix0" @@ -631282,27 +633860,27 @@ }, { "sim":52.0, - "partner":"4j3t" + "partner":"4j3v" }, { "sim":52.0, - "partner":"4j3u" + "partner":"4j3w" }, { "sim":52.0, - "partner":"4j3v" + "partner":"4j3x" }, { "sim":52.0, - "partner":"4j3w" + "partner":"4j3s" }, { "sim":52.0, - "partner":"4j3x" + "partner":"4j3t" }, { "sim":52.0, - "partner":"4j3s" + "partner":"4j3u" }, { "sim":52.0, @@ -631422,11 +634000,11 @@ }, { "sim":51.0, - "partner":"2o4e" + "partner":"2ozn" }, { "sim":51.0, - "partner":"2ozn" + "partner":"2o4e" }, { "sim":51.0, @@ -631438,16 +634016,12 @@ }, { "sim":51.0, - "partner":"5c7p" + "partner":"7f0y" }, { "sim":51.0, "partner":"1wwr" }, - { - "sim":51.0, - "partner":"7f0y" - }, { "sim":51.0, "partner":"7f0z" @@ -631464,6 +634038,10 @@ "sim":51.0, "partner":"7f11" }, + { + "sim":51.0, + "partner":"5c7p" + }, { "sim":51.0, "partner":"4ip3" @@ -631478,11 +634056,11 @@ }, { "sim":51.0, - "partner":"5k24" + "partner":"5k22" }, { "sim":51.0, - "partner":"5k22" + "partner":"5k24" }, { "sim":51.0, @@ -631490,15 +634068,15 @@ }, { "sim":51.0, - "partner":"4nsq" + "partner":"4ohr" }, { "sim":51.0, - "partner":"4ohr" + "partner":"4ohb" }, { "sim":51.0, - "partner":"4ohb" + "partner":"4nsq" }, { "sim":51.0, @@ -631594,19 +634172,19 @@ }, { "sim":51.0, - "partner":"8b9b" + "partner":"8b9a" }, { "sim":51.0, - "partner":"6skl" + "partner":"8b9c" }, { "sim":51.0, - "partner":"8b9a" + "partner":"8b9b" }, { "sim":51.0, - "partner":"8b9c" + "partner":"6skl" }, { "sim":51.0, @@ -631656,14 +634234,6 @@ "sim":51.0, "partner":"2xx3" }, - { - "sim":51.0, - "partner":"7mnq" - }, - { - "sim":51.0, - "partner":"7mnr" - }, { "sim":51.0, "partner":"7mns" @@ -631682,7 +634252,11 @@ }, { "sim":51.0, - "partner":"3la7" + "partner":"7mnq" + }, + { + "sim":51.0, + "partner":"7mnr" }, { "sim":51.0, @@ -631692,6 +634266,10 @@ "sim":51.0, "partner":"3la3" }, + { + "sim":51.0, + "partner":"3la7" + }, { "sim":51.0, "partner":"7edc" @@ -631792,14 +634370,6 @@ "sim":51.0, "partner":"4dmm" }, - { - "sim":51.0, - "partner":"5ds3" - }, - { - "sim":51.0, - "partner":"6bhv" - }, { "sim":51.0, "partner":"6lua" @@ -631834,31 +634404,31 @@ }, { "sim":51.0, - "partner":"2qw4" + "partner":"6bhv" }, { "sim":51.0, - "partner":"4jlj" + "partner":"5ds3" }, { "sim":51.0, - "partner":"7zi1" + "partner":"2qw4" }, { "sim":51.0, - "partner":"4kcg" + "partner":"4jlj" }, { "sim":51.0, - "partner":"7zi2" + "partner":"4kcg" }, { "sim":51.0, - "partner":"4jlk" + "partner":"7zi3" }, { "sim":51.0, - "partner":"7zi3" + "partner":"4jlk" }, { "sim":51.0, @@ -631924,13 +634494,17 @@ "sim":51.0, "partner":"2qro" }, + { + "sim":51.0, + "partner":"7zi5" + }, { "sim":51.0, "partner":"4q1f" }, { "sim":51.0, - "partner":"7zi5" + "partner":"7zi6" }, { "sim":51.0, @@ -631938,11 +634512,11 @@ }, { "sim":51.0, - "partner":"7zi6" + "partner":"7zi7" }, { "sim":51.0, - "partner":"7zi7" + "partner":"7zi8" }, { "sim":51.0, @@ -631950,7 +634524,7 @@ }, { "sim":51.0, - "partner":"7zi8" + "partner":"7zi9" }, { "sim":51.0, @@ -631958,15 +634532,19 @@ }, { "sim":51.0, - "partner":"7zi9" + "partner":"7zia" }, { "sim":51.0, - "partner":"7zia" + "partner":"7zib" }, { "sim":51.0, - "partner":"7zib" + "partner":"7zi1" + }, + { + "sim":51.0, + "partner":"7zi2" }, { "sim":51.0, @@ -631982,19 +634560,19 @@ }, { "sim":51.0, - "partner":"6t2p" + "partner":"6uaw" }, { "sim":51.0, - "partner":"6t2q" + "partner":"6t2o" }, { "sim":51.0, - "partner":"6uaw" + "partner":"6t2p" }, { "sim":51.0, - "partner":"6t2o" + "partner":"6t2q" }, { "sim":51.0, @@ -632006,19 +634584,19 @@ }, { "sim":51.0, - "partner":"7a61" + "partner":"8rwq" }, { "sim":51.0, - "partner":"5uj3" + "partner":"6mnp" }, { "sim":51.0, - "partner":"5uj4" + "partner":"8rwr" }, { "sim":51.0, - "partner":"6mnp" + "partner":"5uj3" }, { "sim":51.0, @@ -632026,7 +634604,11 @@ }, { "sim":51.0, - "partner":"5ul8" + "partner":"8rws" + }, + { + "sim":51.0, + "partner":"5uj4" }, { "sim":51.0, @@ -632040,6 +634622,10 @@ "sim":51.0, "partner":"6d17" }, + { + "sim":51.0, + "partner":"5ul8" + }, { "sim":51.0, "partner":"6d18" @@ -632094,15 +634680,15 @@ }, { "sim":51.0, - "partner":"8rwq" + "partner":"6mey" }, { "sim":51.0, - "partner":"6mey" + "partner":"6v1j" }, { "sim":51.0, - "partner":"6v1j" + "partner":"8aki" }, { "sim":51.0, @@ -632110,7 +634696,7 @@ }, { "sim":51.0, - "partner":"8aki" + "partner":"8akj" }, { "sim":51.0, @@ -632122,7 +634708,7 @@ }, { "sim":51.0, - "partner":"8akj" + "partner":"8akk" }, { "sim":51.0, @@ -632130,47 +634716,47 @@ }, { "sim":51.0, - "partner":"8akk" + "partner":"8akl" }, { "sim":51.0, - "partner":"8akl" + "partner":"8akm" }, { "sim":51.0, - "partner":"8akm" + "partner":"7a61" }, { "sim":51.0, - "partner":"4hu3" + "partner":"8rwo" }, { "sim":51.0, - "partner":"4hu4" + "partner":"8rwp" }, { "sim":51.0, - "partner":"7umj" + "partner":"4hu3" }, { "sim":51.0, - "partner":"6juz" + "partner":"4hu4" }, { "sim":51.0, - "partner":"6jv0" + "partner":"7umj" }, { "sim":51.0, - "partner":"6jv1" + "partner":"6juz" }, { "sim":51.0, - "partner":"3nha" + "partner":"6jv0" }, { "sim":51.0, - "partner":"3nhb" + "partner":"6jv1" }, { "sim":51.0, @@ -632186,7 +634772,11 @@ }, { "sim":51.0, - "partner":"8wlb" + "partner":"3nha" + }, + { + "sim":51.0, + "partner":"3nhb" }, { "sim":51.0, @@ -632202,12 +634792,16 @@ }, { "sim":51.0, - "partner":"6y5x" + "partner":"8wlb" }, { "sim":51.0, "partner":"6y5y" }, + { + "sim":51.0, + "partner":"6y5x" + }, { "sim":51.0, "partner":"5gms" @@ -632232,17 +634826,13 @@ "sim":51.0, "partner":"5um2" }, - { - "sim":51.0, - "partner":"2f9y" - }, { "sim":51.0, "partner":"7clz" }, { "sim":51.0, - "partner":"2pt0" + "partner":"2f9y" }, { "sim":51.0, @@ -632264,6 +634854,10 @@ "sim":51.0, "partner":"2psz" }, + { + "sim":51.0, + "partner":"2pt0" + }, { "sim":51.0, "partner":"6l1g" @@ -632278,27 +634872,27 @@ }, { "sim":51.0, - "partner":"4mfj" + "partner":"4mfl" }, { "sim":51.0, - "partner":"4mfk" + "partner":"4mfp" }, { "sim":51.0, - "partner":"4mfl" + "partner":"4mfq" }, { "sim":51.0, - "partner":"6iix" + "partner":"4mfj" }, { "sim":51.0, - "partner":"4mfp" + "partner":"6iix" }, { "sim":51.0, - "partner":"4mfq" + "partner":"4mfk" }, { "sim":51.0, @@ -632392,14 +634986,6 @@ "sim":51.0, "partner":"7ct4" }, - { - "sim":51.0, - "partner":"3dyh" - }, - { - "sim":51.0, - "partner":"4rxd" - }, { "sim":51.0, "partner":"4rxe" @@ -632442,24 +635028,32 @@ }, { "sim":51.0, - "partner":"6zgp" + "partner":"4rxd" }, { "sim":51.0, - "partner":"6y8j" + "partner":"3dyh" }, { "sim":51.0, - "partner":"6y9c" + "partner":"6y9d" }, { "sim":51.0, - "partner":"6y9d" + "partner":"6zgp" }, { "sim":51.0, "partner":"6y8s" }, + { + "sim":51.0, + "partner":"6y8j" + }, + { + "sim":51.0, + "partner":"6y9c" + }, { "sim":51.0, "partner":"3bu7" @@ -632480,10 +635074,6 @@ "sim":51.0, "partner":"5gk2" }, - { - "sim":51.0, - "partner":"8bdq" - }, { "sim":51.0, "partner":"6m7l" @@ -632494,7 +635084,7 @@ }, { "sim":51.0, - "partner":"3wkr" + "partner":"8bdq" }, { "sim":51.0, @@ -632506,19 +635096,15 @@ }, { "sim":51.0, - "partner":"6pcz" - }, - { - "sim":51.0, - "partner":"6pd0" + "partner":"3wkr" }, { "sim":51.0, - "partner":"7cl7" + "partner":"6pcz" }, { "sim":51.0, - "partner":"7cl8" + "partner":"6pd0" }, { "sim":51.0, @@ -632526,19 +635112,19 @@ }, { "sim":51.0, - "partner":"3m89" + "partner":"7cl7" }, { "sim":51.0, - "partner":"5y0o" + "partner":"7cl8" }, { "sim":51.0, - "partner":"2ca0" + "partner":"3m89" }, { "sim":51.0, - "partner":"4b7s" + "partner":"5y0o" }, { "sim":51.0, @@ -632586,15 +635172,15 @@ }, { "sim":51.0, - "partner":"3c48" + "partner":"2ca0" }, { "sim":51.0, - "partner":"7xbn" + "partner":"4b7s" }, { "sim":51.0, - "partner":"7xbo" + "partner":"3c48" }, { "sim":51.0, @@ -632602,11 +635188,15 @@ }, { "sim":51.0, - "partner":"5upl" + "partner":"7xbn" }, { "sim":51.0, - "partner":"4gt2" + "partner":"7xbo" + }, + { + "sim":51.0, + "partner":"5upl" }, { "sim":51.0, @@ -632614,11 +635204,11 @@ }, { "sim":51.0, - "partner":"6iyt" + "partner":"4gt2" }, { "sim":51.0, - "partner":"2wc4" + "partner":"6iyt" }, { "sim":51.0, @@ -632732,21 +635322,25 @@ "sim":51.0, "partner":"1uz1" }, + { + "sim":51.0, + "partner":"2wc4" + }, { "sim":51.0, "partner":"6ksu" }, { "sim":51.0, - "partner":"5zxg" + "partner":"6ksv" }, { "sim":51.0, - "partner":"6a0j" + "partner":"5zxg" }, { "sim":51.0, - "partner":"6ksv" + "partner":"6a0j" }, { "sim":51.0, @@ -632772,10 +635366,6 @@ "sim":51.0, "partner":"5bwf" }, - { - "sim":51.0, - "partner":"6rk2" - }, { "sim":51.0, "partner":"6rjo" @@ -632788,6 +635378,10 @@ "sim":51.0, "partner":"6rjm" }, + { + "sim":51.0, + "partner":"6rk2" + }, { "sim":51.0, "partner":"6jmw" @@ -632844,14 +635438,6 @@ "sim":51.0, "partner":"6xt1" }, - { - "sim":51.0, - "partner":"8aq3" - }, - { - "sim":51.0, - "partner":"8aq4" - }, { "sim":51.0, "partner":"7aci" @@ -632860,10 +635446,6 @@ "sim":51.0, "partner":"8b0k" }, - { - "sim":51.0, - "partner":"5n6h" - }, { "sim":51.0, "partner":"8b0l" @@ -632876,6 +635458,10 @@ "sim":51.0, "partner":"8b0n" }, + { + "sim":51.0, + "partner":"5n6h" + }, { "sim":51.0, "partner":"8b0o" @@ -632890,15 +635476,19 @@ }, { "sim":51.0, - "partner":"6ms2" + "partner":"8aq3" }, { "sim":51.0, - "partner":"6ms3" + "partner":"8aq4" }, { "sim":51.0, - "partner":"2r0p" + "partner":"6ms2" + }, + { + "sim":51.0, + "partner":"6ms3" }, { "sim":51.0, @@ -632914,7 +635504,7 @@ }, { "sim":51.0, - "partner":"4bzc" + "partner":"2r0p" }, { "sim":51.0, @@ -632922,16 +635512,12 @@ }, { "sim":51.0, - "partner":"6dwk" + "partner":"6dwd" }, { "sim":51.0, "partner":"4qg2" }, - { - "sim":51.0, - "partner":"6dwd" - }, { "sim":51.0, "partner":"7s2y" @@ -632980,6 +635566,14 @@ "sim":51.0, "partner":"4qg0" }, + { + "sim":51.0, + "partner":"6dwk" + }, + { + "sim":51.0, + "partner":"4bzc" + }, { "sim":51.0, "partner":"6e60" @@ -633050,11 +635644,11 @@ }, { "sim":51.0, - "partner":"7jwf" + "partner":"7jw4" }, { "sim":51.0, - "partner":"7jw4" + "partner":"7jwf" }, { "sim":51.0, @@ -633100,10 +635694,6 @@ "sim":51.0, "partner":"7jvi" }, - { - "sim":51.0, - "partner":"6yt0" - }, { "sim":51.0, "partner":"4zhj" @@ -633120,6 +635710,10 @@ "sim":51.0, "partner":"6ytj" }, + { + "sim":51.0, + "partner":"6yt0" + }, { "sim":51.0, "partner":"2zxq" @@ -633176,10 +635770,6 @@ "sim":50.0, "partner":"6h9n" }, - { - "sim":50.0, - "partner":"7vp1" - }, { "sim":50.0, "partner":"7vp2" @@ -633196,6 +635786,10 @@ "sim":50.0, "partner":"7vp4" }, + { + "sim":50.0, + "partner":"7vp1" + }, { "sim":50.0, "partner":"4h2s" @@ -633284,10 +635878,6 @@ "sim":50.0, "partner":"1te4" }, - { - "sim":50.0, - "partner":"4hmr" - }, { "sim":50.0, "partner":"7u0u" @@ -633302,7 +635892,7 @@ }, { "sim":50.0, - "partner":"6bev" + "partner":"4hmr" }, { "sim":50.0, @@ -633318,15 +635908,15 @@ }, { "sim":50.0, - "partner":"2kg1" + "partner":"6bev" }, { "sim":50.0, - "partner":"2hgn" + "partner":"2kg1" }, { "sim":50.0, - "partner":"3vwb" + "partner":"2hgn" }, { "sim":50.0, @@ -633336,6 +635926,10 @@ "sim":50.0, "partner":"3w3c" }, + { + "sim":50.0, + "partner":"3vwb" + }, { "sim":50.0, "partner":"6bbx" @@ -633438,19 +636032,19 @@ }, { "sim":50.0, - "partner":"1x24" + "partner":"4gzd" }, { "sim":50.0, - "partner":"4gzc" + "partner":"1zcl" }, { "sim":50.0, - "partner":"4gzd" + "partner":"1x24" }, { "sim":50.0, - "partner":"1zcl" + "partner":"4gzc" }, { "sim":50.0, @@ -633466,11 +636060,11 @@ }, { "sim":50.0, - "partner":"6uv7" + "partner":"6uvi" }, { "sim":50.0, - "partner":"6uvi" + "partner":"6uv7" }, { "sim":50.0, @@ -633506,23 +636100,19 @@ }, { "sim":50.0, - "partner":"3th5" - }, - { - "sim":50.0, - "partner":"4c76" + "partner":"4gzl" }, { "sim":50.0, - "partner":"4gzl" + "partner":"4gzm" }, { "sim":50.0, - "partner":"4gzm" + "partner":"3th5" }, { "sim":50.0, - "partner":"5l9k" + "partner":"4c76" }, { "sim":50.0, @@ -633538,15 +636128,11 @@ }, { "sim":50.0, - "partner":"4mpz" - }, - { - "sim":50.0, - "partner":"3l1u" + "partner":"5l9k" }, { "sim":50.0, - "partner":"6erd" + "partner":"4mpz" }, { "sim":50.0, @@ -633564,6 +636150,14 @@ "sim":50.0, "partner":"3esr" }, + { + "sim":50.0, + "partner":"6erd" + }, + { + "sim":50.0, + "partner":"3l1u" + }, { "sim":50.0, "partner":"2wc9" @@ -633582,11 +636176,11 @@ }, { "sim":50.0, - "partner":"7fe0" + "partner":"7fe5" }, { "sim":50.0, - "partner":"7fe5" + "partner":"7fe0" }, { "sim":50.0, @@ -633594,11 +636188,11 @@ }, { "sim":50.0, - "partner":"7w83" + "partner":"7ocj" }, { "sim":50.0, - "partner":"7ocj" + "partner":"7w83" }, { "sim":50.0, @@ -633622,11 +636216,11 @@ }, { "sim":50.0, - "partner":"3tjo" + "partner":"7bez" }, { "sim":50.0, - "partner":"7bez" + "partner":"3tjo" }, { "sim":50.0, @@ -633638,15 +636232,15 @@ }, { "sim":50.0, - "partner":"6z0x" + "partner":"6z0y" }, { "sim":50.0, - "partner":"6z0y" + "partner":"6z0e" }, { "sim":50.0, - "partner":"6z0e" + "partner":"6z0x" }, { "sim":50.0, @@ -633690,31 +636284,31 @@ }, { "sim":50.0, - "partner":"6o98" + "partner":"7jh2" }, { "sim":50.0, - "partner":"7d9v" + "partner":"7d8h" }, { "sim":50.0, - "partner":"7d8p" + "partner":"6bn6" }, { "sim":50.0, - "partner":"7jh2" + "partner":"6xfv" }, { "sim":50.0, - "partner":"7d8h" + "partner":"7d9v" }, { "sim":50.0, - "partner":"6bn6" + "partner":"6o98" }, { "sim":50.0, - "partner":"6xfv" + "partner":"7d8p" }, { "sim":50.0, @@ -633788,21 +636382,13 @@ "sim":50.0, "partner":"5vrc" }, - { - "sim":50.0, - "partner":"2wk1" - }, { "sim":50.0, "partner":"6akv" }, { "sim":50.0, - "partner":"7kqj" - }, - { - "sim":50.0, - "partner":"6vqf" + "partner":"2wk1" }, { "sim":50.0, @@ -633842,24 +636428,32 @@ }, { "sim":50.0, - "partner":"1cbf" + "partner":"6u25" }, { "sim":50.0, - "partner":"6u25" + "partner":"7luk" }, { "sim":50.0, - "partner":"7luk" + "partner":"1cbf" }, { "sim":50.0, - "partner":"4rni" + "partner":"6vqf" + }, + { + "sim":50.0, + "partner":"7kqj" }, { "sim":50.0, "partner":"4rnj" }, + { + "sim":50.0, + "partner":"4rni" + }, { "sim":50.0, "partner":"5ldb" @@ -633900,10 +636494,6 @@ "sim":50.0, "partner":"6zzt" }, - { - "sim":50.0, - "partner":"4bwa" - }, { "sim":50.0, "partner":"2zim" @@ -633984,6 +636574,10 @@ "sim":50.0, "partner":"4bw9" }, + { + "sim":50.0, + "partner":"4bwa" + }, { "sim":50.0, "partner":"7bvx" @@ -634016,10 +636610,6 @@ "sim":50.0, "partner":"2oz5" }, - { - "sim":50.0, - "partner":"4rtl" - }, { "sim":50.0, "partner":"4rtm" @@ -634060,6 +636650,10 @@ "sim":50.0, "partner":"4rtk" }, + { + "sim":50.0, + "partner":"4rtl" + }, { "sim":50.0, "partner":"8tez" @@ -634098,24 +636692,20 @@ }, { "sim":50.0, - "partner":"1g8o" + "partner":"3zgd" }, { "sim":50.0, - "partner":"1fg5" + "partner":"1g8o" }, { "sim":50.0, - "partner":"3zgd" + "partner":"1fg5" }, { "sim":50.0, "partner":"1g93" }, - { - "sim":50.0, - "partner":"3g3d" - }, { "sim":50.0, "partner":"3bvj" @@ -634140,6 +636730,10 @@ "sim":50.0, "partner":"4hkp" }, + { + "sim":50.0, + "partner":"3g3d" + }, { "sim":50.0, "partner":"6nr1" @@ -634158,23 +636752,19 @@ }, { "sim":50.0, - "partner":"2qj3" - }, - { - "sim":50.0, - "partner":"7wzv" + "partner":"7wzx" }, { "sim":50.0, - "partner":"7wzx" + "partner":"7x0b" }, { "sim":50.0, - "partner":"7x0b" + "partner":"7wzv" }, { "sim":50.0, - "partner":"3aio" + "partner":"2qj3" }, { "sim":50.0, @@ -634192,6 +636782,10 @@ "sim":50.0, "partner":"3ain" }, + { + "sim":50.0, + "partner":"3aio" + }, { "sim":50.0, "partner":"5zl1" @@ -634218,11 +636812,11 @@ }, { "sim":50.0, - "partner":"6lcn" + "partner":"7x1l" }, { "sim":50.0, - "partner":"7x1l" + "partner":"6lcn" }, { "sim":50.0, @@ -634242,11 +636836,11 @@ }, { "sim":50.0, - "partner":"7cje" + "partner":"7cjg" }, { "sim":50.0, - "partner":"7cjg" + "partner":"7cje" }, { "sim":50.0, @@ -634260,14 +636854,6 @@ "sim":50.0, "partner":"4mfz" }, - { - "sim":50.0, - "partner":"5tyq" - }, - { - "sim":50.0, - "partner":"5u19" - }, { "sim":50.0, "partner":"5u0n" @@ -634286,11 +636872,11 @@ }, { "sim":50.0, - "partner":"5gg5" + "partner":"5tyq" }, { "sim":50.0, - "partner":"5xd1" + "partner":"5u19" }, { "sim":50.0, @@ -634306,27 +636892,27 @@ }, { "sim":50.0, - "partner":"5gg7" + "partner":"6m6y" }, { "sim":50.0, - "partner":"5xd4" + "partner":"5gg7" }, { "sim":50.0, - "partner":"5xd5" + "partner":"5xd4" }, { "sim":50.0, - "partner":"6m6y" + "partner":"6m65" }, { "sim":50.0, - "partner":"5gg8" + "partner":"5xd5" }, { "sim":50.0, - "partner":"6m65" + "partner":"5gg8" }, { "sim":50.0, @@ -634358,19 +636944,15 @@ }, { "sim":50.0, - "partner":"7r2e" - }, - { - "sim":50.0, - "partner":"3uzz" + "partner":"5gg5" }, { "sim":50.0, - "partner":"4h2w" + "partner":"5xd1" }, { "sim":50.0, - "partner":"3mey" + "partner":"7r2e" }, { "sim":50.0, @@ -634410,15 +636992,15 @@ }, { "sim":50.0, - "partner":"3uzw" + "partner":"6l6w" }, { "sim":50.0, - "partner":"6l6w" + "partner":"6l6x" }, { "sim":50.0, - "partner":"6l6x" + "partner":"3uzw" }, { "sim":50.0, @@ -634434,16 +637016,24 @@ }, { "sim":50.0, - "partner":"7cm8" + "partner":"3uzz" }, { "sim":50.0, - "partner":"7djq" + "partner":"4h2w" + }, + { + "sim":50.0, + "partner":"3mey" }, { "sim":50.0, "partner":"7c35" }, + { + "sim":50.0, + "partner":"7ewo" + }, { "sim":50.0, "partner":"6aif" @@ -634458,7 +637048,7 @@ }, { "sim":50.0, - "partner":"7ewo" + "partner":"7cm8" }, { "sim":50.0, @@ -634466,19 +637056,19 @@ }, { "sim":50.0, - "partner":"7cxs" + "partner":"7djq" }, { "sim":50.0, - "partner":"7cxu" + "partner":"7cxs" }, { "sim":50.0, - "partner":"7cxv" + "partner":"7cxu" }, { "sim":50.0, - "partner":"2ikf" + "partner":"7cxv" }, { "sim":50.0, @@ -634508,6 +637098,10 @@ "sim":50.0, "partner":"5kal" }, + { + "sim":50.0, + "partner":"2ikf" + }, { "sim":50.0, "partner":"7y5i" @@ -634538,23 +637132,23 @@ }, { "sim":50.0, - "partner":"1x19" + "partner":"1x1b" }, { "sim":50.0, - "partner":"1x1a" + "partner":"1x1c" }, { "sim":50.0, - "partner":"1x1b" + "partner":"1x1d" }, { "sim":50.0, - "partner":"1x1c" + "partner":"1x19" }, { "sim":50.0, - "partner":"1x1d" + "partner":"1x1a" }, { "sim":50.0, @@ -634568,10 +637162,6 @@ "sim":50.0, "partner":"6clx" }, - { - "sim":50.0, - "partner":"4m1i" - }, { "sim":50.0, "partner":"4d8f" @@ -634586,15 +637176,15 @@ }, { "sim":50.0, - "partner":"1si7" + "partner":"4m1i" }, { "sim":50.0, - "partner":"6rfo" + "partner":"1si7" }, { "sim":50.0, - "partner":"2iua" + "partner":"6rfo" }, { "sim":50.0, @@ -634606,11 +637196,11 @@ }, { "sim":50.0, - "partner":"6rfp" + "partner":"2iua" }, { "sim":50.0, - "partner":"6put" + "partner":"6rfp" }, { "sim":50.0, @@ -634624,25 +637214,17 @@ "sim":50.0, "partner":"6v3k" }, - { - "sim":50.0, - "partner":"5u1c" - }, { "sim":50.0, "partner":"6puz" }, { "sim":50.0, - "partner":"3skv" - }, - { - "sim":50.0, - "partner":"4q3r" + "partner":"5u1c" }, { "sim":50.0, - "partner":"4q42" + "partner":"6put" }, { "sim":50.0, @@ -634678,11 +637260,19 @@ }, { "sim":50.0, - "partner":"5j8x" + "partner":"3skv" }, { "sim":50.0, - "partner":"5hxu" + "partner":"4q3r" + }, + { + "sim":50.0, + "partner":"4q42" + }, + { + "sim":50.0, + "partner":"5j8x" }, { "sim":50.0, @@ -634698,15 +637288,15 @@ }, { "sim":50.0, - "partner":"6voy" + "partner":"5hxu" }, { "sim":50.0, - "partner":"5vrd" + "partner":"6voy" }, { "sim":50.0, - "partner":"7dib" + "partner":"5vrd" }, { "sim":50.0, @@ -634718,19 +637308,19 @@ }, { "sim":50.0, - "partner":"5oyc" + "partner":"6ha9" }, { "sim":50.0, - "partner":"6ha9" + "partner":"5oyc" }, { "sim":50.0, - "partner":"5oyd" + "partner":"6haa" }, { "sim":50.0, - "partner":"6haa" + "partner":"5oyd" }, { "sim":50.0, @@ -634738,7 +637328,7 @@ }, { "sim":50.0, - "partner":"6jtl" + "partner":"7dib" }, { "sim":50.0, @@ -634752,6 +637342,10 @@ "sim":50.0, "partner":"6jtk" }, + { + "sim":50.0, + "partner":"6jtl" + }, { "sim":50.0, "partner":"4kpg" @@ -634806,11 +637400,11 @@ }, { "sim":50.0, - "partner":"5xw2" + "partner":"4e2p" }, { "sim":50.0, - "partner":"4e2p" + "partner":"5xw2" }, { "sim":50.0, @@ -634836,14 +637430,6 @@ "sim":50.0, "partner":"2wio" }, - { - "sim":50.0, - "partner":"6j87" - }, - { - "sim":50.0, - "partner":"6j88" - }, { "sim":50.0, "partner":"5y0n" @@ -634858,15 +637444,15 @@ }, { "sim":50.0, - "partner":"7ui4" + "partner":"6j87" }, { "sim":50.0, - "partner":"2yhg" + "partner":"6j88" }, { "sim":50.0, - "partner":"4q6q" + "partner":"7ui4" }, { "sim":50.0, @@ -634884,6 +637470,14 @@ "sim":50.0, "partner":"4q6p" }, + { + "sim":50.0, + "partner":"2yhg" + }, + { + "sim":50.0, + "partner":"4q6q" + }, { "sim":50.0, "partner":"5ysw" @@ -634914,28 +637508,12 @@ }, { "sim":50.0, - "partner":"4wya" - }, - { - "sim":50.0, - "partner":"4wyf" - }, - { - "sim":50.0, - "partner":"4cxq" - }, - { - "sim":50.0, - "partner":"5kgs" + "partner":"4cxr" }, { "sim":50.0, "partner":"4wyg" }, - { - "sim":50.0, - "partner":"4cxr" - }, { "sim":50.0, "partner":"4xjl" @@ -635000,10 +637578,26 @@ "sim":50.0, "partner":"3tfu" }, + { + "sim":50.0, + "partner":"4wya" + }, { "sim":50.0, "partner":"4wye" }, + { + "sim":50.0, + "partner":"4wyf" + }, + { + "sim":50.0, + "partner":"4cxq" + }, + { + "sim":50.0, + "partner":"5kgs" + }, { "sim":50.0, "partner":"5tnu" @@ -635018,15 +637612,15 @@ }, { "sim":50.0, - "partner":"7tfc" + "partner":"7tfe" }, { "sim":50.0, - "partner":"7tfe" + "partner":"7tf9" }, { "sim":50.0, - "partner":"7tf9" + "partner":"7tfc" }, { "sim":50.0, @@ -635038,15 +637632,19 @@ }, { "sim":50.0, - "partner":"5y9h" + "partner":"8wn5" }, { "sim":50.0, - "partner":"6mlh" + "partner":"8wn6" }, { "sim":50.0, - "partner":"6mlw" + "partner":"8wna" + }, + { + "sim":50.0, + "partner":"5y9h" }, { "sim":50.0, @@ -635086,11 +637684,15 @@ }, { "sim":50.0, - "partner":"6j0u" + "partner":"6mlh" }, { "sim":50.0, - "partner":"6oi9" + "partner":"6mlw" + }, + { + "sim":50.0, + "partner":"6j0u" }, { "sim":50.0, @@ -635098,7 +637700,7 @@ }, { "sim":50.0, - "partner":"6vy9" + "partner":"6oi9" }, { "sim":50.0, @@ -635112,6 +637714,10 @@ "sim":50.0, "partner":"5xix" }, + { + "sim":50.0, + "partner":"6vy9" + }, { "sim":50.0, "partner":"4kc7" @@ -635166,11 +637772,11 @@ }, { "sim":50.0, - "partner":"3mjv" + "partner":"6ta8" }, { "sim":50.0, - "partner":"6ta8" + "partner":"3mjv" }, { "sim":50.0, @@ -635246,15 +637852,15 @@ }, { "sim":50.0, - "partner":"6qu3" + "partner":"6qu4" }, { "sim":50.0, - "partner":"6qu4" + "partner":"6qu5" }, { "sim":50.0, - "partner":"6qu5" + "partner":"6qu3" }, { "sim":50.0, @@ -635270,15 +637876,15 @@ }, { "sim":50.0, - "partner":"5kdn" + "partner":"5kds" }, { "sim":50.0, - "partner":"5kds" + "partner":"5kdu" }, { "sim":50.0, - "partner":"5kdu" + "partner":"5kdn" }, { "sim":50.0, @@ -635314,15 +637920,15 @@ }, { "sim":50.0, - "partner":"2vbg" + "partner":"3hx6" }, { "sim":50.0, - "partner":"3hx6" + "partner":"2vbf" }, { "sim":50.0, - "partner":"2vbf" + "partner":"2vbg" }, { "sim":50.0, @@ -635346,15 +637952,15 @@ }, { "sim":50.0, - "partner":"5tsh" + "partner":"6olj" }, { "sim":50.0, - "partner":"6olj" + "partner":"5tsg" }, { "sim":50.0, - "partner":"5tsg" + "partner":"5tsh" }, { "sim":50.0, @@ -635428,10 +638034,6 @@ "sim":50.0, "partner":"8exd" }, - { - "sim":50.0, - "partner":"5t4a" - }, { "sim":50.0, "partner":"5t4c" @@ -635442,7 +638044,7 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"5t4a" }, { "sim":50.0, @@ -635454,15 +638056,15 @@ }, { "sim":50.0, - "partner":"3slk" + "partner":"6edw" }, { "sim":50.0, - "partner":"5n6u" + "partner":"3slk" }, { "sim":50.0, - "partner":"6jr8" + "partner":"5n6u" }, { "sim":50.0, @@ -635472,6 +638074,10 @@ "sim":50.0, "partner":"6jr7" }, + { + "sim":50.0, + "partner":"6jr8" + }, { "sim":50.0, "partner":"5fau" @@ -635614,10 +638220,10 @@ ], "subtitle":"Ancestral petase 35_442", "tags":[ - "petase", "pet", - "hydrolase", "plastic degradation", + "petase", + "hydrolase", "ancestral sequence reconstruction" ], "keywords":[ @@ -635687,11 +638293,11 @@ }, { "sim":51.0, - "partner":"8qae" + "partner":"8qad" }, { "sim":51.0, - "partner":"8qad" + "partner":"8qae" } ], "seq_thr_sim_natural":[ @@ -635733,11 +638339,11 @@ }, { "sim":413.0, - "partner":"7xtu" + "partner":"7xtv" }, { "sim":413.0, - "partner":"7xtv" + "partner":"7xtu" }, { "sim":413.0, @@ -635777,11 +638383,11 @@ }, { "sim":396.0, - "partner":"7e31" + "partner":"7w69" }, { "sim":396.0, - "partner":"7w69" + "partner":"7e31" }, { "sim":396.0, @@ -635791,10 +638397,6 @@ "sim":395.0, "partner":"7nei" }, - { - "sim":394.0, - "partner":"7e30" - }, { "sim":394.0, "partner":"7cuv" @@ -635807,6 +638409,10 @@ "sim":394.0, "partner":"7w6o" }, + { + "sim":394.0, + "partner":"7e30" + }, { "sim":394.0, "partner":"7w6q" @@ -635857,15 +638463,15 @@ }, { "sim":379.0, - "partner":"7cts" + "partner":"8ibl" }, { "sim":379.0, - "partner":"8ibl" + "partner":"8ibm" }, { "sim":379.0, - "partner":"8ibm" + "partner":"7cts" }, { "sim":379.0, @@ -635973,15 +638579,15 @@ }, { "sim":303.0, - "partner":"6kuq" + "partner":"5xjh" }, { "sim":303.0, - "partner":"5xjh" + "partner":"6kuo" }, { "sim":303.0, - "partner":"6kuo" + "partner":"6kuq" }, { "sim":302.0, @@ -636113,23 +638719,23 @@ }, { "sim":272.0, - "partner":"6eqd" + "partner":"6eqg" }, { "sim":272.0, - "partner":"6eqe" + "partner":"6eqh" }, { "sim":272.0, - "partner":"6eqf" + "partner":"6eqd" }, { "sim":272.0, - "partner":"6eqg" + "partner":"6eqe" }, { "sim":272.0, - "partner":"6eqh" + "partner":"6eqf" }, { "sim":271.0, @@ -636191,6 +638797,26 @@ "sim":250.0, "partner":"8spk" }, + { + "sim":243.0, + "partner":"8ytu" + }, + { + "sim":242.0, + "partner":"8ytv" + }, + { + "sim":223.0, + "partner":"8yty" + }, + { + "sim":222.0, + "partner":"8ytw" + }, + { + "sim":218.0, + "partner":"8ytz" + }, { "sim":141.0, "partner":"7pzj" @@ -636203,10 +638829,6 @@ "sim":73.0, "partner":"2fx5" }, - { - "sim":66.0, - "partner":"4ke6" - }, { "sim":66.0, "partner":"4ke7" @@ -636227,6 +638849,10 @@ "sim":66.0, "partner":"3rli" }, + { + "sim":66.0, + "partner":"4ke6" + }, { "sim":61.0, "partner":"2gee" @@ -636243,14 +638869,6 @@ "sim":57.0, "partner":"2vf2" }, - { - "sim":57.0, - "partner":"5gg5" - }, - { - "sim":57.0, - "partner":"5xd1" - }, { "sim":57.0, "partner":"5gg6" @@ -636265,27 +638883,27 @@ }, { "sim":57.0, - "partner":"5gg7" + "partner":"6m6y" }, { "sim":57.0, - "partner":"5xd4" + "partner":"5gg7" }, { "sim":57.0, - "partner":"5xd5" + "partner":"5xd4" }, { "sim":57.0, - "partner":"6m6y" + "partner":"6m65" }, { "sim":57.0, - "partner":"5gg8" + "partner":"5xd5" }, { "sim":57.0, - "partner":"6m65" + "partner":"5gg8" }, { "sim":57.0, @@ -636315,6 +638933,14 @@ "sim":57.0, "partner":"6m69" }, + { + "sim":57.0, + "partner":"5gg5" + }, + { + "sim":57.0, + "partner":"5xd1" + }, { "sim":57.0, "partner":"6pv4" @@ -636405,11 +639031,11 @@ }, { "sim":55.0, - "partner":"6uv7" + "partner":"6uvi" }, { "sim":55.0, - "partner":"6uvi" + "partner":"6uv7" }, { "sim":55.0, @@ -636525,15 +639151,15 @@ }, { "sim":55.0, - "partner":"7w1c" + "partner":"7w1d" }, { "sim":55.0, - "partner":"7w1d" + "partner":"7w1e" }, { "sim":55.0, - "partner":"7w1e" + "partner":"7w1c" }, { "sim":55.0, @@ -636595,17 +639221,13 @@ "sim":54.0, "partner":"4m2m" }, - { - "sim":54.0, - "partner":"3wkr" - }, { "sim":54.0, "partner":"3wks" }, { "sim":54.0, - "partner":"5cu7" + "partner":"3wkr" }, { "sim":54.0, @@ -636621,7 +639243,7 @@ }, { "sim":54.0, - "partner":"4tm4" + "partner":"5cu7" }, { "sim":54.0, @@ -636643,6 +639265,10 @@ "sim":54.0, "partner":"4tm3" }, + { + "sim":54.0, + "partner":"4tm4" + }, { "sim":54.0, "partner":"7ozc" @@ -636673,11 +639299,11 @@ }, { "sim":53.0, - "partner":"3gz2" + "partner":"4le9" }, { "sim":53.0, - "partner":"4le9" + "partner":"3gz2" }, { "sim":53.0, @@ -636755,10 +639381,6 @@ "sim":53.0, "partner":"2fz4" }, - { - "sim":53.0, - "partner":"3la7" - }, { "sim":53.0, "partner":"3la2" @@ -636769,12 +639391,16 @@ }, { "sim":53.0, - "partner":"6ey1" + "partner":"3la7" }, { "sim":53.0, "partner":"6f0w" }, + { + "sim":53.0, + "partner":"6ey1" + }, { "sim":53.0, "partner":"5owf" @@ -636837,51 +639463,51 @@ }, { "sim":53.0, - "partner":"7q2b" + "partner":"7q2f" }, { "sim":53.0, - "partner":"3ha3" + "partner":"7q2g" }, { "sim":53.0, - "partner":"7q2c" + "partner":"7q2h" }, { "sim":53.0, - "partner":"7q2d" + "partner":"3ha5" }, { "sim":53.0, - "partner":"7q2e" + "partner":"2fk7" }, { "sim":53.0, - "partner":"7q2f" + "partner":"2fk8" }, { "sim":53.0, - "partner":"7q2g" + "partner":"3ha7" }, { "sim":53.0, - "partner":"7q2h" + "partner":"7q2b" }, { "sim":53.0, - "partner":"3ha5" + "partner":"7q2c" }, { "sim":53.0, - "partner":"2fk7" + "partner":"3ha3" }, { "sim":53.0, - "partner":"2fk8" + "partner":"7q2d" }, { "sim":53.0, - "partner":"3ha7" + "partner":"7q2e" }, { "sim":53.0, @@ -636929,19 +639555,15 @@ }, { "sim":53.0, - "partner":"4ltz" - }, - { - "sim":53.0, - "partner":"7kj8" + "partner":"3kbk" }, { "sim":53.0, - "partner":"7kj9" + "partner":"6ax9" }, { "sim":53.0, - "partner":"3kbk" + "partner":"7kjd" }, { "sim":53.0, @@ -636949,7 +639571,7 @@ }, { "sim":53.0, - "partner":"6ax9" + "partner":"7kje" }, { "sim":53.0, @@ -636957,43 +639579,35 @@ }, { "sim":53.0, - "partner":"8su2" - }, - { - "sim":53.0, - "partner":"8su3" - }, - { - "sim":53.0, - "partner":"7kjd" + "partner":"6axu" }, { "sim":53.0, - "partner":"8su4" + "partner":"7kjf" }, { "sim":53.0, - "partner":"6axu" + "partner":"8su2" }, { "sim":53.0, - "partner":"7kje" + "partner":"7kjg" }, { "sim":53.0, - "partner":"8su5" + "partner":"8su3" }, { "sim":53.0, - "partner":"7kjf" + "partner":"8su4" }, { "sim":53.0, - "partner":"7kjg" + "partner":"4lxw" }, { "sim":53.0, - "partner":"4lxw" + "partner":"8su5" }, { "sim":53.0, @@ -637037,11 +639651,15 @@ }, { "sim":53.0, - "partner":"4q3r" + "partner":"7kj8" }, { "sim":53.0, - "partner":"4q42" + "partner":"4ltz" + }, + { + "sim":53.0, + "partner":"7kj9" }, { "sim":53.0, @@ -637077,7 +639695,11 @@ }, { "sim":53.0, - "partner":"5hxu" + "partner":"4q3r" + }, + { + "sim":53.0, + "partner":"4q42" }, { "sim":53.0, @@ -637097,7 +639719,7 @@ }, { "sim":53.0, - "partner":"4lre" + "partner":"5hxu" }, { "sim":53.0, @@ -637131,6 +639753,10 @@ "sim":53.0, "partner":"4lrd" }, + { + "sim":53.0, + "partner":"4lre" + }, { "sim":53.0, "partner":"5ysw" @@ -637151,10 +639777,6 @@ "sim":53.0, "partner":"7vb6" }, - { - "sim":53.0, - "partner":"2imc" - }, { "sim":53.0, "partner":"2ilp" @@ -637179,6 +639801,10 @@ "sim":53.0, "partner":"2imb" }, + { + "sim":53.0, + "partner":"2imc" + }, { "sim":53.0, "partner":"8vwk" @@ -637193,15 +639819,15 @@ }, { "sim":53.0, - "partner":"8il0" + "partner":"2rim" }, { "sim":53.0, - "partner":"2rim" + "partner":"8ila" }, { "sim":53.0, - "partner":"8ila" + "partner":"8il0" }, { "sim":53.0, @@ -637371,10 +639997,6 @@ "sim":52.0, "partner":"5m6m" }, - { - "sim":52.0, - "partner":"3qna" - }, { "sim":52.0, "partner":"3qn0" @@ -637385,7 +640007,7 @@ }, { "sim":52.0, - "partner":"7vo0" + "partner":"3qna" }, { "sim":52.0, @@ -637411,6 +640033,10 @@ "sim":52.0, "partner":"7x75" }, + { + "sim":52.0, + "partner":"7vo0" + }, { "sim":52.0, "partner":"5cab" @@ -637441,11 +640067,11 @@ }, { "sim":52.0, - "partner":"4o8t" + "partner":"4o8l" }, { "sim":52.0, - "partner":"4o8l" + "partner":"4o8t" }, { "sim":52.0, @@ -637513,23 +640139,23 @@ }, { "sim":52.0, - "partner":"6ub4" + "partner":"6ub2" }, { "sim":52.0, - "partner":"6ub5" + "partner":"6ub3" }, { "sim":52.0, - "partner":"6ub6" + "partner":"6ub4" }, { "sim":52.0, - "partner":"6ub2" + "partner":"6ub5" }, { "sim":52.0, - "partner":"6ub3" + "partner":"6ub6" }, { "sim":52.0, @@ -637537,11 +640163,11 @@ }, { "sim":52.0, - "partner":"6hxo" + "partner":"6hxn" }, { "sim":52.0, - "partner":"6hxn" + "partner":"6hxo" }, { "sim":52.0, @@ -637611,10 +640237,6 @@ "sim":52.0, "partner":"1tz6" }, - { - "sim":52.0, - "partner":"5zkj" - }, { "sim":52.0, "partner":"6iid" @@ -637625,11 +640247,11 @@ }, { "sim":52.0, - "partner":"6jtz" + "partner":"5zkj" }, { "sim":52.0, - "partner":"7ajm" + "partner":"6jtz" }, { "sim":52.0, @@ -637645,15 +640267,7 @@ }, { "sim":52.0, - "partner":"8wpo" - }, - { - "sim":52.0, - "partner":"8wph" - }, - { - "sim":52.0, - "partner":"8wpi" + "partner":"7ajm" }, { "sim":52.0, @@ -637673,23 +640287,15 @@ }, { "sim":52.0, - "partner":"7a53" - }, - { - "sim":52.0, - "partner":"7ajw" - }, - { - "sim":52.0, - "partner":"7akb" + "partner":"8wpo" }, { "sim":52.0, - "partner":"7ajy" + "partner":"8wph" }, { "sim":52.0, - "partner":"7a5l" + "partner":"8wpi" }, { "sim":52.0, @@ -637751,57 +640357,65 @@ "sim":52.0, "partner":"7aka" }, + { + "sim":52.0, + "partner":"7a53" + }, { "sim":52.0, "partner":"7akl" }, { "sim":52.0, - "partner":"8tne" + "partner":"7ajw" }, { "sim":52.0, - "partner":"4aub" + "partner":"7akb" }, { "sim":52.0, - "partner":"3skv" + "partner":"7ajy" }, { "sim":52.0, - "partner":"2elb" + "partner":"7a5l" }, { "sim":52.0, - "partner":"7sc6" + "partner":"8tne" }, { "sim":52.0, - "partner":"7scq" + "partner":"4aub" }, { "sim":52.0, - "partner":"8d89" + "partner":"3skv" }, { "sim":52.0, - "partner":"6p5r" + "partner":"2elb" }, { "sim":52.0, - "partner":"5tum" + "partner":"7scq" }, { "sim":52.0, - "partner":"2y46" + "partner":"7sc6" }, { "sim":52.0, - "partner":"2y5n" + "partner":"8d89" }, { "sim":52.0, - "partner":"2yca" + "partner":"6p5r" + }, + { + "sim":52.0, + "partner":"5tum" }, { "sim":52.0, @@ -637825,47 +640439,47 @@ }, { "sim":52.0, - "partner":"4euh" + "partner":"2y46" }, { "sim":52.0, - "partner":"4ggv" + "partner":"2y5n" }, { "sim":52.0, - "partner":"4eue" + "partner":"2yca" }, { "sim":52.0, - "partner":"4euf" + "partner":"4ggv" }, { "sim":52.0, - "partner":"7cl7" + "partner":"4eue" }, { "sim":52.0, - "partner":"7cl8" + "partner":"4euf" }, { "sim":52.0, - "partner":"6l69" + "partner":"4euh" }, { "sim":52.0, - "partner":"5y0o" + "partner":"6l69" }, { "sim":52.0, - "partner":"6ry0" + "partner":"7cl7" }, { "sim":52.0, - "partner":"6ry1" + "partner":"7cl8" }, { "sim":52.0, - "partner":"6ry2" + "partner":"5y0o" }, { "sim":52.0, @@ -637881,43 +640495,43 @@ }, { "sim":52.0, - "partner":"7n18" + "partner":"6ry0" }, { "sim":52.0, - "partner":"4kp1" + "partner":"6ry1" }, { "sim":52.0, - "partner":"3hzz" + "partner":"6ry2" }, { "sim":52.0, - "partner":"4l6w" + "partner":"7n18" }, { "sim":52.0, - "partner":"6u4z" + "partner":"4kp1" }, { "sim":52.0, - "partner":"8aq3" + "partner":"3hzz" }, { "sim":52.0, - "partner":"8aq4" + "partner":"4l6w" }, { "sim":52.0, - "partner":"7aci" + "partner":"6u4z" }, { "sim":52.0, - "partner":"8b0k" + "partner":"7aci" }, { "sim":52.0, - "partner":"5n6h" + "partner":"8b0k" }, { "sim":52.0, @@ -637931,6 +640545,10 @@ "sim":52.0, "partner":"8b0n" }, + { + "sim":52.0, + "partner":"5n6h" + }, { "sim":52.0, "partner":"8b0o" @@ -637943,6 +640561,14 @@ "sim":52.0, "partner":"5n6l" }, + { + "sim":52.0, + "partner":"8aq3" + }, + { + "sim":52.0, + "partner":"8aq4" + }, { "sim":52.0, "partner":"5jjq" @@ -638063,10 +640689,6 @@ "sim":51.0, "partner":"3wbg" }, - { - "sim":51.0, - "partner":"5hso" - }, { "sim":51.0, "partner":"5x7z" @@ -638081,7 +640703,7 @@ }, { "sim":51.0, - "partner":"6ebc" + "partner":"5hso" }, { "sim":51.0, @@ -638095,6 +640717,10 @@ "sim":51.0, "partner":"6eb4" }, + { + "sim":51.0, + "partner":"6ebc" + }, { "sim":51.0, "partner":"5x9k" @@ -638117,19 +640743,19 @@ }, { "sim":51.0, - "partner":"5k24" + "partner":"7ccm" }, { "sim":51.0, - "partner":"7ccl" + "partner":"5k22" }, { "sim":51.0, - "partner":"7ccm" + "partner":"7ccl" }, { "sim":51.0, - "partner":"5k22" + "partner":"5k24" }, { "sim":51.0, @@ -638237,11 +640863,11 @@ }, { "sim":51.0, - "partner":"4jr4" + "partner":"4jr6" }, { "sim":51.0, - "partner":"4jr6" + "partner":"4jr4" }, { "sim":51.0, @@ -638299,14 +640925,6 @@ "sim":51.0, "partner":"2ntn" }, - { - "sim":51.0, - "partner":"5ds3" - }, - { - "sim":51.0, - "partner":"6bhv" - }, { "sim":51.0, "partner":"6ntu" @@ -638331,6 +640949,14 @@ "sim":51.0, "partner":"6nrj" }, + { + "sim":51.0, + "partner":"6bhv" + }, + { + "sim":51.0, + "partner":"5ds3" + }, { "sim":51.0, "partner":"5d6t" @@ -638365,23 +640991,23 @@ }, { "sim":51.0, - "partner":"6fcn" + "partner":"6fcm" }, { "sim":51.0, - "partner":"6t2p" + "partner":"6fcn" }, { "sim":51.0, - "partner":"6t2q" + "partner":"6t2o" }, { "sim":51.0, - "partner":"6fcm" + "partner":"6t2p" }, { "sim":51.0, - "partner":"6t2o" + "partner":"6t2q" }, { "sim":51.0, @@ -638465,19 +641091,19 @@ }, { "sim":51.0, - "partner":"7a61" + "partner":"8rwq" }, { "sim":51.0, - "partner":"5uj3" + "partner":"6mnp" }, { "sim":51.0, - "partner":"5uj4" + "partner":"8rwr" }, { "sim":51.0, - "partner":"6mnp" + "partner":"5uj3" }, { "sim":51.0, @@ -638485,11 +641111,11 @@ }, { "sim":51.0, - "partner":"5ocw" + "partner":"8rws" }, { "sim":51.0, - "partner":"5ul8" + "partner":"5uj4" }, { "sim":51.0, @@ -638503,6 +641129,14 @@ "sim":51.0, "partner":"6d17" }, + { + "sim":51.0, + "partner":"5ocw" + }, + { + "sim":51.0, + "partner":"5ul8" + }, { "sim":51.0, "partner":"6d18" @@ -638557,15 +641191,15 @@ }, { "sim":51.0, - "partner":"8rwq" + "partner":"6mey" }, { "sim":51.0, - "partner":"6mey" + "partner":"6v1j" }, { "sim":51.0, - "partner":"6v1j" + "partner":"8aki" }, { "sim":51.0, @@ -638573,7 +641207,7 @@ }, { "sim":51.0, - "partner":"8aki" + "partner":"8akj" }, { "sim":51.0, @@ -638585,7 +641219,7 @@ }, { "sim":51.0, - "partner":"8akj" + "partner":"8akk" }, { "sim":51.0, @@ -638593,31 +641227,35 @@ }, { "sim":51.0, - "partner":"8akk" + "partner":"8akl" }, { "sim":51.0, - "partner":"8akl" + "partner":"8akm" }, { "sim":51.0, - "partner":"8akm" + "partner":"7a61" }, { "sim":51.0, - "partner":"2xx7" + "partner":"8rwo" }, { "sim":51.0, - "partner":"6loi" + "partner":"8rwp" }, { "sim":51.0, - "partner":"5y7x" + "partner":"2xx7" }, { "sim":51.0, - "partner":"6wye" + "partner":"6loi" + }, + { + "sim":51.0, + "partner":"5y7x" }, { "sim":51.0, @@ -638635,6 +641273,10 @@ "sim":51.0, "partner":"7ra4" }, + { + "sim":51.0, + "partner":"6wye" + }, { "sim":51.0, "partner":"7xbr" @@ -638661,19 +641303,19 @@ }, { "sim":51.0, - "partner":"3nha" + "partner":"3nh6" }, { "sim":51.0, - "partner":"3nhb" + "partner":"3nh9" }, { "sim":51.0, - "partner":"3nh6" + "partner":"3nha" }, { "sim":51.0, - "partner":"3nh9" + "partner":"3nhb" }, { "sim":51.0, @@ -638693,15 +641335,15 @@ }, { "sim":51.0, - "partner":"6l3w" + "partner":"6nok" }, { "sim":51.0, - "partner":"6nok" + "partner":"6dke" }, { "sim":51.0, - "partner":"6dke" + "partner":"6l3w" }, { "sim":51.0, @@ -638731,10 +641373,6 @@ "sim":51.0, "partner":"2qj3" }, - { - "sim":51.0, - "partner":"3aio" - }, { "sim":51.0, "partner":"7ctx" @@ -638761,15 +641399,11 @@ }, { "sim":51.0, - "partner":"1u2j" - }, - { - "sim":51.0, - "partner":"2nq6" + "partner":"3aio" }, { "sim":51.0, - "partner":"2nq7" + "partner":"1u2j" }, { "sim":51.0, @@ -638811,6 +641445,14 @@ "sim":51.0, "partner":"2gz5" }, + { + "sim":51.0, + "partner":"2nq6" + }, + { + "sim":51.0, + "partner":"2nq7" + }, { "sim":51.0, "partner":"6djt" @@ -638859,14 +641501,6 @@ "sim":51.0, "partner":"4jna" }, - { - "sim":51.0, - "partner":"6q4x" - }, - { - "sim":51.0, - "partner":"6q4y" - }, { "sim":51.0, "partner":"6q4z" @@ -638885,15 +641519,15 @@ }, { "sim":51.0, - "partner":"6l1g" + "partner":"6q4x" }, { "sim":51.0, - "partner":"4mfj" + "partner":"6q4y" }, { "sim":51.0, - "partner":"4mfk" + "partner":"6l1g" }, { "sim":51.0, @@ -638901,19 +641535,23 @@ }, { "sim":51.0, - "partner":"6iix" + "partner":"4mfp" }, { "sim":51.0, - "partner":"4mfp" + "partner":"4mfq" }, { "sim":51.0, - "partner":"4mfq" + "partner":"4mfj" }, { "sim":51.0, - "partner":"6vwr" + "partner":"6iix" + }, + { + "sim":51.0, + "partner":"4mfk" }, { "sim":51.0, @@ -638927,6 +641565,10 @@ "sim":51.0, "partner":"6vwq" }, + { + "sim":51.0, + "partner":"6vwr" + }, { "sim":51.0, "partner":"4l3f" @@ -638943,6 +641585,10 @@ "sim":51.0, "partner":"2pvj" }, + { + "sim":51.0, + "partner":"7cxs" + }, { "sim":51.0, "partner":"2pvk" @@ -638959,10 +641605,6 @@ "sim":51.0, "partner":"2pvm" }, - { - "sim":51.0, - "partner":"7cxs" - }, { "sim":51.0, "partner":"2pvn" @@ -638985,23 +641627,23 @@ }, { "sim":51.0, - "partner":"1x19" + "partner":"1x1b" }, { "sim":51.0, - "partner":"1x1a" + "partner":"1x1c" }, { "sim":51.0, - "partner":"1x1b" + "partner":"1x1d" }, { "sim":51.0, - "partner":"1x1c" + "partner":"1x19" }, { "sim":51.0, - "partner":"1x1d" + "partner":"1x1a" }, { "sim":51.0, @@ -639081,15 +641723,15 @@ }, { "sim":51.0, - "partner":"2o0h" + "partner":"2o0j" }, { "sim":51.0, - "partner":"2o0j" + "partner":"2o0k" }, { "sim":51.0, - "partner":"2o0k" + "partner":"2o0h" }, { "sim":51.0, @@ -639187,10 +641829,6 @@ "sim":51.0, "partner":"5xpj" }, - { - "sim":51.0, - "partner":"5dvi" - }, { "sim":51.0, "partner":"5dvj" @@ -639201,12 +641839,16 @@ }, { "sim":51.0, - "partner":"6e9b" + "partner":"5dvi" }, { "sim":51.0, "partner":"6e57" }, + { + "sim":51.0, + "partner":"6e9b" + }, { "sim":51.0, "partner":"3zu2" @@ -639243,10 +641885,6 @@ "sim":51.0, "partner":"5y0n" }, - { - "sim":51.0, - "partner":"4q6q" - }, { "sim":51.0, "partner":"4q6m" @@ -639263,6 +641901,10 @@ "sim":51.0, "partner":"4q6p" }, + { + "sim":51.0, + "partner":"4q6q" + }, { "sim":51.0, "partner":"7r37" @@ -639357,15 +641999,15 @@ }, { "sim":51.0, - "partner":"4l2h" + "partner":"4epp" }, { "sim":51.0, - "partner":"4epp" + "partner":"4epq" }, { "sim":51.0, - "partner":"4epq" + "partner":"4l2h" }, { "sim":51.0, @@ -639379,14 +642021,6 @@ "sim":51.0, "partner":"5hat" }, - { - "sim":51.0, - "partner":"5hjx" - }, - { - "sim":51.0, - "partner":"5koz" - }, { "sim":51.0, "partner":"5hjy" @@ -639403,6 +642037,10 @@ "sim":51.0, "partner":"4lf1" }, + { + "sim":51.0, + "partner":"5koz" + }, { "sim":51.0, "partner":"4lf2" @@ -639413,7 +642051,7 @@ }, { "sim":51.0, - "partner":"7f79" + "partner":"5hjx" }, { "sim":51.0, @@ -639421,15 +642059,15 @@ }, { "sim":51.0, - "partner":"8hcz" + "partner":"7f79" }, { "sim":51.0, - "partner":"5hqm" + "partner":"8hcz" }, { "sim":51.0, - "partner":"6rk2" + "partner":"5hqm" }, { "sim":51.0, @@ -639445,11 +642083,11 @@ }, { "sim":51.0, - "partner":"4iei" + "partner":"6rjk" }, { "sim":51.0, - "partner":"6rjk" + "partner":"4iei" }, { "sim":51.0, @@ -639457,7 +642095,7 @@ }, { "sim":51.0, - "partner":"5uno" + "partner":"6rk2" }, { "sim":51.0, @@ -639475,6 +642113,10 @@ "sim":51.0, "partner":"5bkm" }, + { + "sim":51.0, + "partner":"5uno" + }, { "sim":51.0, "partner":"6rim" @@ -639491,10 +642133,6 @@ "sim":51.0, "partner":"6ad3" }, - { - "sim":51.0, - "partner":"2cj9" - }, { "sim":51.0, "partner":"2cja" @@ -639509,7 +642147,7 @@ }, { "sim":51.0, - "partner":"5kdn" + "partner":"2cj9" }, { "sim":51.0, @@ -639519,6 +642157,10 @@ "sim":51.0, "partner":"5kdu" }, + { + "sim":51.0, + "partner":"5kdn" + }, { "sim":51.0, "partner":"3n6r" @@ -639539,17 +642181,13 @@ "sim":51.0, "partner":"6a50" }, - { - "sim":51.0, - "partner":"4nhx" - }, { "sim":51.0, "partner":"4nhy" }, { "sim":51.0, - "partner":"5wm2" + "partner":"4nhx" }, { "sim":51.0, @@ -639571,6 +642209,10 @@ "sim":51.0, "partner":"5wm7" }, + { + "sim":51.0, + "partner":"5wm2" + }, { "sim":51.0, "partner":"7jvh" @@ -639593,15 +642235,15 @@ }, { "sim":51.0, - "partner":"5tsh" + "partner":"6olj" }, { "sim":51.0, - "partner":"6olj" + "partner":"5tsg" }, { "sim":51.0, - "partner":"5tsg" + "partner":"5tsh" }, { "sim":51.0, @@ -639609,15 +642251,15 @@ }, { "sim":51.0, - "partner":"8hdf" + "partner":"8hd4" }, { "sim":51.0, - "partner":"8iqu" + "partner":"8hdf" }, { "sim":51.0, - "partner":"8hd4" + "partner":"8iqu" }, { "sim":51.0, @@ -639643,10 +642285,6 @@ "sim":51.0, "partner":"6ouw" }, - { - "sim":51.0, - "partner":"2fw3" - }, { "sim":51.0, "partner":"4ep9" @@ -639667,6 +642305,10 @@ "sim":51.0, "partner":"4eph" }, + { + "sim":51.0, + "partner":"2fw3" + }, { "sim":51.0, "partner":"2ix0" @@ -639709,15 +642351,15 @@ }, { "sim":51.0, - "partner":"6jr8" + "partner":"6jr6" }, { "sim":51.0, - "partner":"6jr6" + "partner":"6jr7" }, { "sim":51.0, - "partner":"6jr7" + "partner":"6jr8" }, { "sim":51.0, @@ -639765,11 +642407,11 @@ }, { "sim":50.0, - "partner":"4oxc" + "partner":"6gjw" }, { "sim":50.0, - "partner":"6gjw" + "partner":"4oxc" }, { "sim":50.0, @@ -639797,15 +642439,15 @@ }, { "sim":50.0, - "partner":"7p4y" + "partner":"7p50" }, { "sim":50.0, - "partner":"7p50" + "partner":"6t3o" }, { "sim":50.0, - "partner":"6t3o" + "partner":"7p4y" }, { "sim":50.0, @@ -639851,17 +642493,13 @@ "sim":50.0, "partner":"4tns" }, - { - "sim":50.0, - "partner":"5x3t" - }, { "sim":50.0, "partner":"6cky" }, { "sim":50.0, - "partner":"6suj" + "partner":"5x3t" }, { "sim":50.0, @@ -639869,11 +642507,11 @@ }, { "sim":50.0, - "partner":"3zhn" + "partner":"6suj" }, { "sim":50.0, - "partner":"3sw1" + "partner":"3zhn" }, { "sim":50.0, @@ -639897,16 +642535,20 @@ }, { "sim":50.0, - "partner":"7r4s" + "partner":"6gg9" }, { "sim":50.0, - "partner":"6gg9" + "partner":"7r4s" }, { "sim":50.0, "partner":"8a33" }, + { + "sim":50.0, + "partner":"3sw1" + }, { "sim":50.0, "partner":"6ogx" @@ -639969,15 +642611,15 @@ }, { "sim":50.0, - "partner":"7xtl" + "partner":"7f13" }, { "sim":50.0, - "partner":"7f13" + "partner":"7f14" }, { "sim":50.0, - "partner":"7f14" + "partner":"7xtl" }, { "sim":50.0, @@ -639997,15 +642639,15 @@ }, { "sim":50.0, - "partner":"1x24" + "partner":"1zcl" }, { "sim":50.0, - "partner":"5ujf" + "partner":"1x24" }, { "sim":50.0, - "partner":"1zcl" + "partner":"5ujf" }, { "sim":50.0, @@ -640051,10 +642693,6 @@ "sim":50.0, "partner":"7q4t" }, - { - "sim":50.0, - "partner":"3l1u" - }, { "sim":50.0, "partner":"3l1v" @@ -640073,7 +642711,7 @@ }, { "sim":50.0, - "partner":"3kwe" + "partner":"3l1u" }, { "sim":50.0, @@ -640081,23 +642719,23 @@ }, { "sim":50.0, - "partner":"8b9b" + "partner":"3kwe" }, { "sim":50.0, - "partner":"6skl" + "partner":"8b9a" }, { "sim":50.0, - "partner":"8b9a" + "partner":"8b9c" }, { "sim":50.0, - "partner":"8b9c" + "partner":"8b9b" }, { "sim":50.0, - "partner":"3oci" + "partner":"6skl" }, { "sim":50.0, @@ -640111,6 +642749,10 @@ "sim":50.0, "partner":"3oc3" }, + { + "sim":50.0, + "partner":"3oci" + }, { "sim":50.0, "partner":"3tue" @@ -640279,10 +642921,6 @@ "sim":50.0, "partner":"5vrc" }, - { - "sim":50.0, - "partner":"4fq7" - }, { "sim":50.0, "partner":"1y0x" @@ -640295,6 +642933,10 @@ "sim":50.0, "partner":"4fq5" }, + { + "sim":50.0, + "partner":"4fq7" + }, { "sim":50.0, "partner":"6ypa" @@ -640329,15 +642971,15 @@ }, { "sim":50.0, - "partner":"2ovb" + "partner":"2ovf" }, { "sim":50.0, - "partner":"2ovf" + "partner":"2ov8" }, { "sim":50.0, - "partner":"2ov8" + "partner":"2ovb" }, { "sim":50.0, @@ -640351,10 +642993,6 @@ "sim":50.0, "partner":"7umj" }, - { - "sim":50.0, - "partner":"4pgc" - }, { "sim":50.0, "partner":"4pgd" @@ -640371,6 +643009,10 @@ "sim":50.0, "partner":"4pgb" }, + { + "sim":50.0, + "partner":"4pgc" + }, { "sim":50.0, "partner":"8tms" @@ -640409,27 +643051,27 @@ }, { "sim":50.0, - "partner":"5gmr" + "partner":"3u3k" }, { "sim":50.0, - "partner":"7tzl" + "partner":"3u3m" }, { "sim":50.0, - "partner":"3u3r" + "partner":"5gmr" }, { "sim":50.0, - "partner":"3u3k" + "partner":"3u3o" }, { "sim":50.0, - "partner":"3u3m" + "partner":"7tzl" }, { "sim":50.0, - "partner":"3u3o" + "partner":"3u3r" }, { "sim":50.0, @@ -640541,11 +643183,11 @@ }, { "sim":50.0, - "partner":"7btm" + "partner":"7bsx" }, { "sim":50.0, - "partner":"7bsx" + "partner":"7btm" }, { "sim":50.0, @@ -640579,10 +643221,6 @@ "sim":50.0, "partner":"7smi" }, - { - "sim":50.0, - "partner":"3uzz" - }, { "sim":50.0, "partner":"3g1r" @@ -640601,15 +643239,15 @@ }, { "sim":50.0, - "partner":"3uzw" + "partner":"6l6w" }, { "sim":50.0, - "partner":"6l6w" + "partner":"6l6x" }, { "sim":50.0, - "partner":"6l6x" + "partner":"3uzw" }, { "sim":50.0, @@ -640623,6 +643261,10 @@ "sim":50.0, "partner":"3uzy" }, + { + "sim":50.0, + "partner":"3uzz" + }, { "sim":50.0, "partner":"8afu" @@ -640671,6 +643313,10 @@ "sim":50.0, "partner":"5vxe" }, + { + "sim":50.0, + "partner":"7a19" + }, { "sim":50.0, "partner":"5vxf" @@ -640681,7 +643327,7 @@ }, { "sim":50.0, - "partner":"7a19" + "partner":"7a1a" }, { "sim":50.0, @@ -640695,10 +643341,6 @@ "sim":50.0, "partner":"5vxh" }, - { - "sim":50.0, - "partner":"7a1a" - }, { "sim":50.0, "partner":"6b2t" @@ -640715,10 +643357,6 @@ "sim":50.0, "partner":"5ysz" }, - { - "sim":50.0, - "partner":"4m1i" - }, { "sim":50.0, "partner":"4d8f" @@ -640735,6 +643373,10 @@ "sim":50.0, "partner":"1t9r" }, + { + "sim":50.0, + "partner":"4m1i" + }, { "sim":50.0, "partner":"7t71" @@ -640845,31 +643487,31 @@ }, { "sim":50.0, - "partner":"6zgp" + "partner":"6y9d" }, { "sim":50.0, - "partner":"6y8j" + "partner":"6zgp" }, { "sim":50.0, - "partner":"6y9c" + "partner":"2qap" }, { "sim":50.0, - "partner":"6y9d" + "partner":"6y8s" }, { "sim":50.0, - "partner":"2qap" + "partner":"2qdg" }, { "sim":50.0, - "partner":"6y8s" + "partner":"6y8j" }, { "sim":50.0, - "partner":"2qdg" + "partner":"6y9c" }, { "sim":50.0, @@ -640969,19 +643611,19 @@ }, { "sim":50.0, - "partner":"3ssn" + "partner":"8d19" }, { "sim":50.0, - "partner":"8d19" + "partner":"3ssn" }, { "sim":50.0, - "partner":"3sso" + "partner":"8czk" }, { "sim":50.0, - "partner":"8czk" + "partner":"3sso" }, { "sim":50.0, @@ -641017,11 +643659,11 @@ }, { "sim":50.0, - "partner":"5d40" + "partner":"5d3u" }, { "sim":50.0, - "partner":"5d3u" + "partner":"5d40" }, { "sim":50.0, @@ -641071,14 +643713,6 @@ "sim":50.0, "partner":"2hp0" }, - { - "sim":50.0, - "partner":"6mlh" - }, - { - "sim":50.0, - "partner":"6mlw" - }, { "sim":50.0, "partner":"6nn1" @@ -641105,16 +643739,24 @@ }, { "sim":50.0, - "partner":"2gps" + "partner":"6mlh" }, { "sim":50.0, - "partner":"6oi9" + "partner":"6mlw" }, { "sim":50.0, "partner":"2gpw" }, + { + "sim":50.0, + "partner":"2gps" + }, + { + "sim":50.0, + "partner":"6oi9" + }, { "sim":50.0, "partner":"3tai" @@ -641129,11 +643771,11 @@ }, { "sim":50.0, - "partner":"6vy9" + "partner":"6vya" }, { "sim":50.0, - "partner":"6vya" + "partner":"6vy9" }, { "sim":50.0, @@ -641241,11 +643883,11 @@ }, { "sim":50.0, - "partner":"1nj5" + "partner":"6p4o" }, { "sim":50.0, - "partner":"6p4o" + "partner":"1nj5" }, { "sim":50.0, @@ -641265,15 +643907,15 @@ }, { "sim":50.0, - "partner":"4dqw" + "partner":"6gjv" }, { "sim":50.0, - "partner":"6gjv" + "partner":"6gk9" }, { "sim":50.0, - "partner":"6gk9" + "partner":"4dqw" }, { "sim":50.0, @@ -641351,21 +643993,17 @@ "sim":50.0, "partner":"3p0b" }, - { - "sim":50.0, - "partner":"6crm" - }, { "sim":50.0, "partner":"4tmu" }, { "sim":50.0, - "partner":"6gnf" + "partner":"6crm" }, { "sim":50.0, - "partner":"2r0p" + "partner":"6gnf" }, { "sim":50.0, @@ -641381,7 +644019,7 @@ }, { "sim":50.0, - "partner":"4bzc" + "partner":"2r0p" }, { "sim":50.0, @@ -641389,16 +644027,12 @@ }, { "sim":50.0, - "partner":"6dwk" + "partner":"6dwd" }, { "sim":50.0, "partner":"4qg2" }, - { - "sim":50.0, - "partner":"6dwd" - }, { "sim":50.0, "partner":"7s2y" @@ -641447,6 +644081,14 @@ "sim":50.0, "partner":"4qg0" }, + { + "sim":50.0, + "partner":"6dwk" + }, + { + "sim":50.0, + "partner":"4bzc" + }, { "sim":50.0, "partner":"6jfb" @@ -641581,47 +644223,47 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"6edz" }, { "sim":50.0, - "partner":"6edz" + "partner":"6ee1" }, { "sim":50.0, - "partner":"6ee1" + "partner":"6edw" }, { "sim":50.0, - "partner":"3ahc" + "partner":"3ahf" }, { "sim":50.0, - "partner":"3ahd" + "partner":"3ahg" }, { "sim":50.0, - "partner":"3ahe" + "partner":"3ahh" }, { "sim":50.0, - "partner":"3ahf" + "partner":"3ahi" }, { "sim":50.0, - "partner":"3ahg" + "partner":"3ahj" }, { "sim":50.0, - "partner":"3ahh" + "partner":"3ahc" }, { "sim":50.0, - "partner":"3ahi" + "partner":"3ahd" }, { "sim":50.0, - "partner":"3ahj" + "partner":"3ahe" }, { "sim":50.0, @@ -641637,15 +644279,15 @@ }, { "sim":50.0, - "partner":"6tsh" + "partner":"6tsk" }, { "sim":50.0, - "partner":"6tte" + "partner":"6tsh" }, { "sim":50.0, - "partner":"6tsk" + "partner":"6tte" }, { "sim":50.0, @@ -641729,10 +644371,10 @@ ], "subtitle":"Ancestral petase 35_442 mutant e13d", "tags":[ - "petase", "pet", - "hydrolase", "plastic degradation", + "petase", + "hydrolase", "ancestral sequence reconstruction" ], "keywords":[ @@ -641802,19 +644444,19 @@ }, { "sim":51.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":51.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":51.0, - "partner":"8w08" + "partner":"8w06" }, { "sim":51.0, - "partner":"8w05" + "partner":"8v0a" }, { "sim":50.0, @@ -641864,11 +644506,11 @@ }, { "sim":415.0, - "partner":"7xtu" + "partner":"7xtv" }, { "sim":415.0, - "partner":"7xtv" + "partner":"7xtu" }, { "sim":415.0, @@ -641908,11 +644550,11 @@ }, { "sim":395.0, - "partner":"7e31" + "partner":"7w69" }, { "sim":395.0, - "partner":"7w69" + "partner":"7e31" }, { "sim":395.0, @@ -641922,10 +644564,6 @@ "sim":394.0, "partner":"7nei" }, - { - "sim":393.0, - "partner":"7e30" - }, { "sim":393.0, "partner":"7cuv" @@ -641938,6 +644576,10 @@ "sim":393.0, "partner":"7w6o" }, + { + "sim":393.0, + "partner":"7e30" + }, { "sim":393.0, "partner":"7w6q" @@ -641996,15 +644638,15 @@ }, { "sim":377.0, - "partner":"7cts" + "partner":"8ibl" }, { "sim":377.0, - "partner":"8ibl" + "partner":"8ibm" }, { "sim":377.0, - "partner":"8ibm" + "partner":"7cts" }, { "sim":376.0, @@ -642056,15 +644698,15 @@ }, { "sim":325.0, - "partner":"7vvc" + "partner":"7w45" }, { "sim":325.0, - "partner":"7w45" + "partner":"7w1n" }, { "sim":325.0, - "partner":"7w1n" + "partner":"7vvc" }, { "sim":319.0, @@ -642104,15 +644746,15 @@ }, { "sim":303.0, - "partner":"6kuq" + "partner":"5xjh" }, { "sim":303.0, - "partner":"5xjh" + "partner":"6kuo" }, { "sim":303.0, - "partner":"6kuo" + "partner":"6kuq" }, { "sim":302.0, @@ -642244,23 +644886,23 @@ }, { "sim":271.0, - "partner":"6eqd" + "partner":"6eqg" }, { "sim":271.0, - "partner":"6eqe" + "partner":"6eqh" }, { "sim":271.0, - "partner":"6eqf" + "partner":"6eqd" }, { "sim":271.0, - "partner":"6eqg" + "partner":"6eqe" }, { "sim":271.0, - "partner":"6eqh" + "partner":"6eqf" }, { "sim":270.0, @@ -642322,6 +644964,26 @@ "sim":252.0, "partner":"8spk" }, + { + "sim":243.0, + "partner":"8ytu" + }, + { + "sim":241.0, + "partner":"8ytv" + }, + { + "sim":223.0, + "partner":"8yty" + }, + { + "sim":221.0, + "partner":"8ytw" + }, + { + "sim":217.0, + "partner":"8ytz" + }, { "sim":141.0, "partner":"7pzj" @@ -642334,10 +644996,6 @@ "sim":72.0, "partner":"2fx5" }, - { - "sim":64.0, - "partner":"4ke6" - }, { "sim":64.0, "partner":"4ke7" @@ -642358,6 +645016,10 @@ "sim":64.0, "partner":"3rli" }, + { + "sim":64.0, + "partner":"4ke6" + }, { "sim":61.0, "partner":"4ke9" @@ -642406,26 +645068,6 @@ "sim":57.0, "partner":"6ve6" }, - { - "sim":57.0, - "partner":"7q2b" - }, - { - "sim":57.0, - "partner":"3ha3" - }, - { - "sim":57.0, - "partner":"7q2c" - }, - { - "sim":57.0, - "partner":"7q2d" - }, - { - "sim":57.0, - "partner":"7q2e" - }, { "sim":57.0, "partner":"7q2f" @@ -642456,7 +645098,23 @@ }, { "sim":57.0, - "partner":"4lre" + "partner":"7q2b" + }, + { + "sim":57.0, + "partner":"7q2c" + }, + { + "sim":57.0, + "partner":"3ha3" + }, + { + "sim":57.0, + "partner":"7q2d" + }, + { + "sim":57.0, + "partner":"7q2e" }, { "sim":57.0, @@ -642490,6 +645148,10 @@ "sim":57.0, "partner":"4lrd" }, + { + "sim":57.0, + "partner":"4lre" + }, { "sim":57.0, "partner":"3zpp" @@ -642564,15 +645226,15 @@ }, { "sim":56.0, - "partner":"7w1c" + "partner":"7w1d" }, { "sim":56.0, - "partner":"7w1d" + "partner":"7w1e" }, { "sim":56.0, - "partner":"7w1e" + "partner":"7w1c" }, { "sim":56.0, @@ -642584,11 +645246,11 @@ }, { "sim":55.0, - "partner":"3kwe" + "partner":"3kwd" }, { "sim":55.0, - "partner":"3kwd" + "partner":"3kwe" }, { "sim":55.0, @@ -642604,19 +645266,19 @@ }, { "sim":55.0, - "partner":"7q4u" + "partner":"7zf2" }, { "sim":55.0, - "partner":"7q59" + "partner":"7q4u" }, { "sim":55.0, - "partner":"7pp4" + "partner":"7q59" }, { "sim":55.0, - "partner":"7zf2" + "partner":"7pp4" }, { "sim":55.0, @@ -642626,10 +645288,6 @@ "sim":55.0, "partner":"5xpj" }, - { - "sim":55.0, - "partner":"5dvi" - }, { "sim":55.0, "partner":"5dvj" @@ -642640,15 +645298,15 @@ }, { "sim":55.0, - "partner":"3s8m" + "partner":"5dvi" }, { "sim":55.0, - "partner":"4y1b" + "partner":"3s8m" }, { "sim":55.0, - "partner":"5cu7" + "partner":"4y1b" }, { "sim":55.0, @@ -642666,6 +645324,10 @@ "sim":55.0, "partner":"5cx4" }, + { + "sim":55.0, + "partner":"5cu7" + }, { "sim":55.0, "partner":"4doy" @@ -642774,14 +645436,6 @@ "sim":54.0, "partner":"5hk8" }, - { - "sim":54.0, - "partner":"2nq6" - }, - { - "sim":54.0, - "partner":"2nq7" - }, { "sim":54.0, "partner":"2b3k" @@ -642822,6 +645476,14 @@ "sim":54.0, "partner":"2gz5" }, + { + "sim":54.0, + "partner":"2nq6" + }, + { + "sim":54.0, + "partner":"2nq7" + }, { "sim":54.0, "partner":"4qii" @@ -642838,10 +645500,6 @@ "sim":54.0, "partner":"3t8b" }, - { - "sim":54.0, - "partner":"2o0h" - }, { "sim":54.0, "partner":"2o0j" @@ -642852,15 +645510,15 @@ }, { "sim":54.0, - "partner":"2o1b" + "partner":"2o0h" }, { "sim":54.0, - "partner":"4bko" + "partner":"2o1b" }, { "sim":54.0, - "partner":"4tm4" + "partner":"4bko" }, { "sim":54.0, @@ -642882,6 +645540,10 @@ "sim":54.0, "partner":"4tm3" }, + { + "sim":54.0, + "partner":"4tm4" + }, { "sim":54.0, "partner":"7ovw" @@ -643014,10 +645676,6 @@ "sim":53.0, "partner":"4p9g" }, - { - "sim":53.0, - "partner":"5l9k" - }, { "sim":53.0, "partner":"5l9q" @@ -643032,15 +645690,15 @@ }, { "sim":53.0, - "partner":"6pj9" + "partner":"5l9k" }, { "sim":53.0, - "partner":"6pja" + "partner":"6pjp" }, { "sim":53.0, - "partner":"6pjp" + "partner":"6pjq" }, { "sim":53.0, @@ -643048,11 +645706,11 @@ }, { "sim":53.0, - "partner":"6pjq" + "partner":"6pjr" }, { "sim":53.0, - "partner":"6pjr" + "partner":"6pju" }, { "sim":53.0, @@ -643062,10 +645720,6 @@ "sim":53.0, "partner":"5f5d" }, - { - "sim":53.0, - "partner":"6pju" - }, { "sim":53.0, "partner":"4njp" @@ -643088,15 +645742,19 @@ }, { "sim":53.0, - "partner":"5f5j" + "partner":"6pj5" }, { "sim":53.0, - "partner":"6pj5" + "partner":"6pj7" }, { "sim":53.0, - "partner":"6pj7" + "partner":"5f5j" + }, + { + "sim":53.0, + "partner":"6pj8" }, { "sim":53.0, @@ -643104,7 +645762,11 @@ }, { "sim":53.0, - "partner":"6pj8" + "partner":"6pj9" + }, + { + "sim":53.0, + "partner":"6pja" }, { "sim":53.0, @@ -643124,31 +645786,31 @@ }, { "sim":53.0, - "partner":"6ey1" + "partner":"6f0w" }, { "sim":53.0, - "partner":"6f0w" + "partner":"6ey1" }, { "sim":53.0, - "partner":"6ub4" + "partner":"6ub2" }, { "sim":53.0, - "partner":"6ub5" + "partner":"6ub3" }, { "sim":53.0, - "partner":"6ub6" + "partner":"6ub4" }, { "sim":53.0, - "partner":"6ub2" + "partner":"6ub5" }, { "sim":53.0, - "partner":"6ub3" + "partner":"6ub6" }, { "sim":53.0, @@ -643156,11 +645818,11 @@ }, { "sim":53.0, - "partner":"6hxo" + "partner":"6hxn" }, { "sim":53.0, - "partner":"6hxn" + "partner":"6hxo" }, { "sim":53.0, @@ -643182,10 +645844,6 @@ "sim":53.0, "partner":"4xld" }, - { - "sim":53.0, - "partner":"3s3h" - }, { "sim":53.0, "partner":"3s3k" @@ -643198,6 +645856,10 @@ "sim":53.0, "partner":"3s3f" }, + { + "sim":53.0, + "partner":"3s3h" + }, { "sim":53.0, "partner":"7k67" @@ -643234,10 +645896,6 @@ "sim":53.0, "partner":"8e1x" }, - { - "sim":53.0, - "partner":"2pt0" - }, { "sim":53.0, "partner":"3d1o" @@ -643258,6 +645916,10 @@ "sim":53.0, "partner":"2psz" }, + { + "sim":53.0, + "partner":"2pt0" + }, { "sim":53.0, "partner":"4xq6" @@ -643346,10 +646008,6 @@ "sim":53.0, "partner":"5o8e" }, - { - "sim":53.0, - "partner":"6rk2" - }, { "sim":53.0, "partner":"6rjo" @@ -643362,6 +646020,10 @@ "sim":53.0, "partner":"6rjm" }, + { + "sim":53.0, + "partner":"6rk2" + }, { "sim":53.0, "partner":"1z63" @@ -643426,10 +646088,6 @@ "sim":53.0, "partner":"5x7h" }, - { - "sim":53.0, - "partner":"5y1h" - }, { "sim":53.0, "partner":"5y1k" @@ -643476,15 +646134,19 @@ }, { "sim":53.0, - "partner":"6tsh" + "partner":"5y1h" }, { "sim":53.0, - "partner":"6tte" + "partner":"6tsk" }, { "sim":53.0, - "partner":"6tsk" + "partner":"6tsh" + }, + { + "sim":53.0, + "partner":"6tte" }, { "sim":53.0, @@ -643544,11 +646206,11 @@ }, { "sim":52.0, - "partner":"1wc6" + "partner":"1wc1" }, { "sim":52.0, - "partner":"1wc1" + "partner":"1wc6" }, { "sim":52.0, @@ -643556,16 +646218,12 @@ }, { "sim":52.0, - "partner":"7o2t" + "partner":"6z17" }, { "sim":52.0, "partner":"7o2u" }, - { - "sim":52.0, - "partner":"6z17" - }, { "sim":52.0, "partner":"6yz3" @@ -643582,6 +646240,10 @@ "sim":52.0, "partner":"6z5k" }, + { + "sim":52.0, + "partner":"7o2t" + }, { "sim":52.0, "partner":"1zw9" @@ -643602,10 +646264,6 @@ "sim":52.0, "partner":"3c0e" }, - { - "sim":52.0, - "partner":"3la7" - }, { "sim":52.0, "partner":"3la2" @@ -643618,6 +646276,10 @@ "sim":52.0, "partner":"3qc1" }, + { + "sim":52.0, + "partner":"3la7" + }, { "sim":52.0, "partner":"6kdr" @@ -643718,10 +646380,6 @@ "sim":52.0, "partner":"6itx" }, - { - "sim":52.0, - "partner":"4pgc" - }, { "sim":52.0, "partner":"4pgd" @@ -643738,6 +646396,10 @@ "sim":52.0, "partner":"4pgb" }, + { + "sim":52.0, + "partner":"4pgc" + }, { "sim":52.0, "partner":"6xtu" @@ -643764,7 +646426,7 @@ }, { "sim":52.0, - "partner":"6lcn" + "partner":"7bsx" }, { "sim":52.0, @@ -643772,7 +646434,7 @@ }, { "sim":52.0, - "partner":"7bsx" + "partner":"6lcn" }, { "sim":52.0, @@ -643786,14 +646448,6 @@ "sim":52.0, "partner":"6kxh" }, - { - "sim":52.0, - "partner":"5gg5" - }, - { - "sim":52.0, - "partner":"5xd1" - }, { "sim":52.0, "partner":"5gg6" @@ -643808,27 +646462,27 @@ }, { "sim":52.0, - "partner":"5gg7" + "partner":"6m6y" }, { "sim":52.0, - "partner":"5xd4" + "partner":"5gg7" }, { "sim":52.0, - "partner":"5xd5" + "partner":"5xd4" }, { "sim":52.0, - "partner":"6m6y" + "partner":"6m65" }, { "sim":52.0, - "partner":"5gg8" + "partner":"5xd5" }, { "sim":52.0, - "partner":"6m65" + "partner":"5gg8" }, { "sim":52.0, @@ -643860,23 +646514,15 @@ }, { "sim":52.0, - "partner":"3pdc" - }, - { - "sim":52.0, - "partner":"4g2f" - }, - { - "sim":52.0, - "partner":"4gk3" + "partner":"5gg5" }, { "sim":52.0, - "partner":"4gk4" + "partner":"5xd1" }, { "sim":52.0, - "partner":"4p5q" + "partner":"3pdc" }, { "sim":52.0, @@ -643904,16 +646550,32 @@ }, { "sim":52.0, - "partner":"5eeg" + "partner":"4g2f" }, { "sim":52.0, - "partner":"5jr3" + "partner":"4gk3" + }, + { + "sim":52.0, + "partner":"4gk4" + }, + { + "sim":52.0, + "partner":"4p5q" }, { "sim":52.0, "partner":"5eeh" }, + { + "sim":52.0, + "partner":"5eeg" + }, + { + "sim":52.0, + "partner":"5jr3" + }, { "sim":52.0, "partner":"5kbz" @@ -643988,11 +646650,11 @@ }, { "sim":52.0, - "partner":"3i68" + "partner":"6u76" }, { "sim":52.0, - "partner":"6u76" + "partner":"3i68" }, { "sim":52.0, @@ -644024,15 +646686,15 @@ }, { "sim":52.0, - "partner":"7cl7" + "partner":"6l69" }, { "sim":52.0, - "partner":"7cl8" + "partner":"7cl7" }, { "sim":52.0, - "partner":"6l69" + "partner":"7cl8" }, { "sim":52.0, @@ -644040,27 +646702,27 @@ }, { "sim":52.0, - "partner":"6ry0" + "partner":"6ry5" }, { "sim":52.0, - "partner":"6ry1" + "partner":"6ry6" }, { "sim":52.0, - "partner":"6ry2" + "partner":"6ry7" }, { "sim":52.0, - "partner":"6ry5" + "partner":"6ry0" }, { "sim":52.0, - "partner":"6ry6" + "partner":"6ry1" }, { "sim":52.0, - "partner":"6ry7" + "partner":"6ry2" }, { "sim":52.0, @@ -644072,11 +646734,11 @@ }, { "sim":52.0, - "partner":"8il0" + "partner":"8ila" }, { "sim":52.0, - "partner":"8ila" + "partner":"8il0" }, { "sim":52.0, @@ -644084,15 +646746,19 @@ }, { "sim":52.0, - "partner":"4acg" + "partner":"4ach" }, { "sim":52.0, - "partner":"4ach" + "partner":"3e1h" }, { "sim":52.0, - "partner":"3e1h" + "partner":"8wn5" + }, + { + "sim":52.0, + "partner":"8wn6" }, { "sim":52.0, @@ -644102,6 +646768,14 @@ "sim":52.0, "partner":"4acd" }, + { + "sim":52.0, + "partner":"8wna" + }, + { + "sim":52.0, + "partner":"4acg" + }, { "sim":52.0, "partner":"2fwr" @@ -644142,26 +646816,18 @@ "sim":52.0, "partner":"7wh0" }, - { - "sim":52.0, - "partner":"4bzc" - }, { "sim":52.0, "partner":"4qg1" }, { "sim":52.0, - "partner":"6dwk" + "partner":"6dwd" }, { "sim":52.0, "partner":"4qg2" }, - { - "sim":52.0, - "partner":"6dwd" - }, { "sim":52.0, "partner":"7s2y" @@ -644210,6 +646876,14 @@ "sim":52.0, "partner":"4qg0" }, + { + "sim":52.0, + "partner":"6dwk" + }, + { + "sim":52.0, + "partner":"4bzc" + }, { "sim":52.0, "partner":"5jjq" @@ -644242,17 +646916,13 @@ "sim":52.0, "partner":"5wdg" }, - { - "sim":52.0, - "partner":"7jwf" - }, { "sim":52.0, "partner":"7jw4" }, { "sim":52.0, - "partner":"2fw3" + "partner":"7jwf" }, { "sim":52.0, @@ -644274,6 +646944,10 @@ "sim":52.0, "partner":"4eph" }, + { + "sim":52.0, + "partner":"2fw3" + }, { "sim":52.0, "partner":"7xsy" @@ -644288,27 +646962,27 @@ }, { "sim":52.0, - "partner":"4j3t" + "partner":"4j3v" }, { "sim":52.0, - "partner":"4j3u" + "partner":"4j3w" }, { "sim":52.0, - "partner":"4j3v" + "partner":"4j3x" }, { "sim":52.0, - "partner":"4j3w" + "partner":"4j3s" }, { "sim":52.0, - "partner":"4j3x" + "partner":"4j3t" }, { "sim":52.0, - "partner":"4j3s" + "partner":"4j3u" }, { "sim":52.0, @@ -644380,11 +647054,11 @@ }, { "sim":51.0, - "partner":"7p4y" + "partner":"7p50" }, { "sim":51.0, - "partner":"7p50" + "partner":"7p4y" }, { "sim":51.0, @@ -644446,10 +647120,6 @@ "sim":51.0, "partner":"8v0h" }, - { - "sim":51.0, - "partner":"6ebc" - }, { "sim":51.0, "partner":"6ebd" @@ -644462,6 +647132,10 @@ "sim":51.0, "partner":"6eb4" }, + { + "sim":51.0, + "partner":"6ebc" + }, { "sim":51.0, "partner":"2ls6" @@ -644624,19 +647298,19 @@ }, { "sim":51.0, - "partner":"8b9b" + "partner":"8b9a" }, { "sim":51.0, - "partner":"6skl" + "partner":"8b9c" }, { "sim":51.0, - "partner":"8b9a" + "partner":"8b9b" }, { "sim":51.0, - "partner":"8b9c" + "partner":"6skl" }, { "sim":51.0, @@ -644664,15 +647338,15 @@ }, { "sim":51.0, - "partner":"6njq" + "partner":"1zye" }, { "sim":51.0, - "partner":"1zye" + "partner":"4mh2" }, { "sim":51.0, - "partner":"4mh2" + "partner":"6njq" }, { "sim":51.0, @@ -644692,27 +647366,27 @@ }, { "sim":51.0, - "partner":"7mnq" + "partner":"7mns" }, { "sim":51.0, - "partner":"7mnr" + "partner":"7mnt" }, { "sim":51.0, - "partner":"7mns" + "partner":"7mnu" }, { "sim":51.0, - "partner":"7mnt" + "partner":"7mnv" }, { "sim":51.0, - "partner":"7mnu" + "partner":"7mnq" }, { "sim":51.0, - "partner":"7mnv" + "partner":"7mnr" }, { "sim":51.0, @@ -644790,18 +647464,6 @@ "sim":51.0, "partner":"4dmm" }, - { - "sim":51.0, - "partner":"5ds3" - }, - { - "sim":51.0, - "partner":"6bhv" - }, - { - "sim":51.0, - "partner":"1z5z" - }, { "sim":51.0, "partner":"6lua" @@ -644836,32 +647498,36 @@ }, { "sim":51.0, - "partner":"5ltv" + "partner":"6bhv" }, { "sim":51.0, - "partner":"4jlj" + "partner":"5ds3" }, { "sim":51.0, - "partner":"7zi1" + "partner":"1z5z" }, { "sim":51.0, - "partner":"4kcg" + "partner":"5ltv" }, { "sim":51.0, - "partner":"7zi2" + "partner":"4jlj" }, { "sim":51.0, - "partner":"4jlk" + "partner":"4kcg" }, { "sim":51.0, "partner":"7zi3" }, + { + "sim":51.0, + "partner":"4jlk" + }, { "sim":51.0, "partner":"2no6" @@ -644926,13 +647592,17 @@ "sim":51.0, "partner":"2qro" }, + { + "sim":51.0, + "partner":"7zi5" + }, { "sim":51.0, "partner":"4q1f" }, { "sim":51.0, - "partner":"7zi5" + "partner":"7zi6" }, { "sim":51.0, @@ -644940,11 +647610,11 @@ }, { "sim":51.0, - "partner":"7zi6" + "partner":"7zi7" }, { "sim":51.0, - "partner":"7zi7" + "partner":"7zi8" }, { "sim":51.0, @@ -644952,7 +647622,7 @@ }, { "sim":51.0, - "partner":"7zi8" + "partner":"7zi9" }, { "sim":51.0, @@ -644960,15 +647630,19 @@ }, { "sim":51.0, - "partner":"7zi9" + "partner":"7zia" }, { "sim":51.0, - "partner":"7zia" + "partner":"7zib" }, { "sim":51.0, - "partner":"7zib" + "partner":"7zi1" + }, + { + "sim":51.0, + "partner":"7zi2" }, { "sim":51.0, @@ -644980,11 +647654,11 @@ }, { "sim":51.0, - "partner":"6t2p" + "partner":"6t2o" }, { "sim":51.0, - "partner":"2wk1" + "partner":"6t2p" }, { "sim":51.0, @@ -644992,7 +647666,7 @@ }, { "sim":51.0, - "partner":"6t2o" + "partner":"2wk1" }, { "sim":51.0, @@ -645000,19 +647674,19 @@ }, { "sim":51.0, - "partner":"7a61" + "partner":"8rwq" }, { "sim":51.0, - "partner":"5uj3" + "partner":"6mnp" }, { "sim":51.0, - "partner":"5uj4" + "partner":"8rwr" }, { "sim":51.0, - "partner":"6mnp" + "partner":"5uj3" }, { "sim":51.0, @@ -645020,7 +647694,11 @@ }, { "sim":51.0, - "partner":"5ul8" + "partner":"8rws" + }, + { + "sim":51.0, + "partner":"5uj4" }, { "sim":51.0, @@ -645034,6 +647712,10 @@ "sim":51.0, "partner":"6d17" }, + { + "sim":51.0, + "partner":"5ul8" + }, { "sim":51.0, "partner":"6d18" @@ -645088,15 +647770,15 @@ }, { "sim":51.0, - "partner":"8rwq" + "partner":"6mey" }, { "sim":51.0, - "partner":"6mey" + "partner":"6v1j" }, { "sim":51.0, - "partner":"6v1j" + "partner":"8aki" }, { "sim":51.0, @@ -645104,7 +647786,7 @@ }, { "sim":51.0, - "partner":"8aki" + "partner":"8akj" }, { "sim":51.0, @@ -645116,7 +647798,7 @@ }, { "sim":51.0, - "partner":"8akj" + "partner":"8akk" }, { "sim":51.0, @@ -645124,15 +647806,23 @@ }, { "sim":51.0, - "partner":"8akk" + "partner":"8akl" }, { "sim":51.0, - "partner":"8akl" + "partner":"8akm" }, { "sim":51.0, - "partner":"8akm" + "partner":"7a61" + }, + { + "sim":51.0, + "partner":"8rwo" + }, + { + "sim":51.0, + "partner":"8rwp" }, { "sim":51.0, @@ -645164,35 +647854,35 @@ }, { "sim":51.0, - "partner":"8wlb" + "partner":"8wl5" }, { "sim":51.0, - "partner":"6vlx" + "partner":"8wl7" }, { "sim":51.0, - "partner":"6vly" + "partner":"8wl9" }, { "sim":51.0, - "partner":"8wl5" + "partner":"8wlb" }, { "sim":51.0, - "partner":"8wl7" + "partner":"6vlx" }, { "sim":51.0, - "partner":"8wl9" + "partner":"6vly" }, { "sim":51.0, - "partner":"6y5x" + "partner":"6y5y" }, { "sim":51.0, - "partner":"6y5y" + "partner":"6y5x" }, { "sim":51.0, @@ -645214,10 +647904,6 @@ "sim":51.0, "partner":"3a99" }, - { - "sim":51.0, - "partner":"3aio" - }, { "sim":51.0, "partner":"3aik" @@ -645234,6 +647920,10 @@ "sim":51.0, "partner":"3ain" }, + { + "sim":51.0, + "partner":"3aio" + }, { "sim":51.0, "partner":"3jrq" @@ -645248,7 +647938,7 @@ }, { "sim":51.0, - "partner":"7drp" + "partner":"7drm" }, { "sim":51.0, @@ -645256,11 +647946,11 @@ }, { "sim":51.0, - "partner":"7drm" + "partner":"2b4o" }, { "sim":51.0, - "partner":"2b4o" + "partner":"7drn" }, { "sim":51.0, @@ -645268,11 +647958,11 @@ }, { "sim":51.0, - "partner":"7drn" + "partner":"7dro" }, { "sim":51.0, - "partner":"7dro" + "partner":"7drp" }, { "sim":51.0, @@ -645284,27 +647974,27 @@ }, { "sim":51.0, - "partner":"5tyq" + "partner":"5u0n" }, { "sim":51.0, - "partner":"5u19" + "partner":"5u1e" }, { "sim":51.0, - "partner":"5u0n" + "partner":"5u0t" }, { "sim":51.0, - "partner":"5u1e" + "partner":"5u1i" }, { "sim":51.0, - "partner":"5u0t" + "partner":"5tyq" }, { "sim":51.0, - "partner":"5u1i" + "partner":"5u19" }, { "sim":51.0, @@ -645320,31 +648010,27 @@ }, { "sim":51.0, - "partner":"4mfj" - }, - { - "sim":51.0, - "partner":"4mfk" + "partner":"4mfl" }, { "sim":51.0, - "partner":"4mfl" + "partner":"4mfp" }, { "sim":51.0, - "partner":"6iix" + "partner":"4mfq" }, { "sim":51.0, - "partner":"4mfp" + "partner":"4mfj" }, { "sim":51.0, - "partner":"4mfq" + "partner":"6iix" }, { "sim":51.0, - "partner":"3uzz" + "partner":"4mfk" }, { "sim":51.0, @@ -645388,11 +648074,11 @@ }, { "sim":51.0, - "partner":"4dr0" + "partner":"3uzz" }, { "sim":51.0, - "partner":"7ajm" + "partner":"4dr0" }, { "sim":51.0, @@ -645408,23 +648094,7 @@ }, { "sim":51.0, - "partner":"7a53" - }, - { - "sim":51.0, - "partner":"7ajw" - }, - { - "sim":51.0, - "partner":"7akb" - }, - { - "sim":51.0, - "partner":"7ajy" - }, - { - "sim":51.0, - "partner":"7a5l" + "partner":"7ajm" }, { "sim":51.0, @@ -645486,10 +648156,30 @@ "sim":51.0, "partner":"7aka" }, + { + "sim":51.0, + "partner":"7a53" + }, { "sim":51.0, "partner":"7akl" }, + { + "sim":51.0, + "partner":"7ajw" + }, + { + "sim":51.0, + "partner":"7akb" + }, + { + "sim":51.0, + "partner":"7ajy" + }, + { + "sim":51.0, + "partner":"7a5l" + }, { "sim":51.0, "partner":"4aub" @@ -645542,14 +648232,6 @@ "sim":51.0, "partner":"8g5s" }, - { - "sim":51.0, - "partner":"3dyh" - }, - { - "sim":51.0, - "partner":"4rxd" - }, { "sim":51.0, "partner":"4rxe" @@ -645592,19 +648274,19 @@ }, { "sim":51.0, - "partner":"6zgp" + "partner":"4rxd" }, { "sim":51.0, - "partner":"6y8j" + "partner":"3dyh" }, { "sim":51.0, - "partner":"6y9c" + "partner":"6y9d" }, { "sim":51.0, - "partner":"6y9d" + "partner":"6zgp" }, { "sim":51.0, @@ -645614,6 +648296,14 @@ "sim":51.0, "partner":"6a4i" }, + { + "sim":51.0, + "partner":"6y8j" + }, + { + "sim":51.0, + "partner":"6y9c" + }, { "sim":51.0, "partner":"3bu7" @@ -645640,15 +648330,15 @@ }, { "sim":51.0, - "partner":"8bdq" + "partner":"6m7l" }, { "sim":51.0, - "partner":"6m7l" + "partner":"4zas" }, { "sim":51.0, - "partner":"4zas" + "partner":"8bdq" }, { "sim":51.0, @@ -645664,11 +648354,11 @@ }, { "sim":51.0, - "partner":"3wkr" + "partner":"3wks" }, { "sim":51.0, - "partner":"3wks" + "partner":"3wkr" }, { "sim":51.0, @@ -645708,11 +648398,11 @@ }, { "sim":51.0, - "partner":"3amu" + "partner":"3amt" }, { "sim":51.0, - "partner":"3amt" + "partner":"3amu" }, { "sim":51.0, @@ -645722,10 +648412,6 @@ "sim":51.0, "partner":"3hzz" }, - { - "sim":51.0, - "partner":"2wc4" - }, { "sim":51.0, "partner":"1oif" @@ -645850,21 +648536,25 @@ "sim":51.0, "partner":"1uz1" }, + { + "sim":51.0, + "partner":"2wc4" + }, { "sim":51.0, "partner":"6ksu" }, { "sim":51.0, - "partner":"5zxg" + "partner":"6ksv" }, { "sim":51.0, - "partner":"6a0j" + "partner":"5zxg" }, { "sim":51.0, - "partner":"6ksv" + "partner":"6a0j" }, { "sim":51.0, @@ -645900,11 +648590,11 @@ }, { "sim":51.0, - "partner":"4mdo" + "partner":"4mdp" }, { "sim":51.0, - "partner":"4mdp" + "partner":"4mdo" }, { "sim":51.0, @@ -645934,10 +648624,6 @@ "sim":51.0, "partner":"6ad3" }, - { - "sim":51.0, - "partner":"2cj9" - }, { "sim":51.0, "partner":"2cja" @@ -645952,23 +648638,19 @@ }, { "sim":51.0, - "partner":"4k2x" - }, - { - "sim":51.0, - "partner":"4s21" + "partner":"2cj9" }, { "sim":51.0, - "partner":"3n6r" + "partner":"4k2x" }, { "sim":51.0, - "partner":"8aq3" + "partner":"4s21" }, { "sim":51.0, - "partner":"8aq4" + "partner":"3n6r" }, { "sim":51.0, @@ -645978,10 +648660,6 @@ "sim":51.0, "partner":"8b0k" }, - { - "sim":51.0, - "partner":"5n6h" - }, { "sim":51.0, "partner":"8b0l" @@ -645994,6 +648672,10 @@ "sim":51.0, "partner":"8b0n" }, + { + "sim":51.0, + "partner":"5n6h" + }, { "sim":51.0, "partner":"8b0o" @@ -646008,7 +648690,11 @@ }, { "sim":51.0, - "partner":"2r0p" + "partner":"8aq3" + }, + { + "sim":51.0, + "partner":"8aq4" }, { "sim":51.0, @@ -646022,6 +648708,10 @@ "sim":51.0, "partner":"3ept" }, + { + "sim":51.0, + "partner":"2r0p" + }, { "sim":51.0, "partner":"3u9s" @@ -646126,10 +648816,6 @@ "sim":51.0, "partner":"6nff" }, - { - "sim":51.0, - "partner":"6jr8" - }, { "sim":51.0, "partner":"6jr6" @@ -646140,11 +648826,11 @@ }, { "sim":51.0, - "partner":"7jvi" + "partner":"6jr8" }, { "sim":51.0, - "partner":"6yt0" + "partner":"7jvi" }, { "sim":51.0, @@ -646162,6 +648848,10 @@ "sim":51.0, "partner":"6ytj" }, + { + "sim":51.0, + "partner":"6yt0" + }, { "sim":51.0, "partner":"2zxq" @@ -646194,10 +648884,6 @@ "sim":50.0, "partner":"2f09" }, - { - "sim":50.0, - "partner":"7vp1" - }, { "sim":50.0, "partner":"7vp2" @@ -646214,6 +648900,10 @@ "sim":50.0, "partner":"7vp4" }, + { + "sim":50.0, + "partner":"7vp1" + }, { "sim":50.0, "partner":"4h2s" @@ -646274,10 +648964,6 @@ "sim":50.0, "partner":"7aby" }, - { - "sim":50.0, - "partner":"4hmr" - }, { "sim":50.0, "partner":"7u0u" @@ -646292,7 +648978,7 @@ }, { "sim":50.0, - "partner":"6bev" + "partner":"4hmr" }, { "sim":50.0, @@ -646320,7 +649006,7 @@ }, { "sim":50.0, - "partner":"3vwb" + "partner":"6bev" }, { "sim":50.0, @@ -646330,6 +649016,10 @@ "sim":50.0, "partner":"3w3c" }, + { + "sim":50.0, + "partner":"3vwb" + }, { "sim":50.0, "partner":"6bbx" @@ -646392,11 +649082,11 @@ }, { "sim":50.0, - "partner":"1wwr" + "partner":"7f0y" }, { "sim":50.0, - "partner":"7f0y" + "partner":"1wwr" }, { "sim":50.0, @@ -646464,19 +649154,19 @@ }, { "sim":50.0, - "partner":"1x24" + "partner":"4gzd" }, { "sim":50.0, - "partner":"4gzc" + "partner":"1zcl" }, { "sim":50.0, - "partner":"4gzd" + "partner":"1x24" }, { "sim":50.0, - "partner":"1zcl" + "partner":"4gzc" }, { "sim":50.0, @@ -646492,11 +649182,11 @@ }, { "sim":50.0, - "partner":"6uv7" + "partner":"6uvi" }, { "sim":50.0, - "partner":"6uvi" + "partner":"6uv7" }, { "sim":50.0, @@ -646528,28 +649218,24 @@ }, { "sim":50.0, - "partner":"3th5" + "partner":"4gzl" }, { "sim":50.0, - "partner":"4c76" + "partner":"4gzm" }, { "sim":50.0, - "partner":"4gzl" + "partner":"3th5" }, { "sim":50.0, - "partner":"4gzm" + "partner":"4c76" }, { "sim":50.0, "partner":"3p6b" }, - { - "sim":50.0, - "partner":"3l1u" - }, { "sim":50.0, "partner":"3l1v" @@ -646566,6 +649252,10 @@ "sim":50.0, "partner":"3esr" }, + { + "sim":50.0, + "partner":"3l1u" + }, { "sim":50.0, "partner":"2wc9" @@ -646588,19 +649278,19 @@ }, { "sim":50.0, - "partner":"7fe0" + "partner":"7fe5" }, { "sim":50.0, - "partner":"7fe5" + "partner":"7fe0" }, { "sim":50.0, - "partner":"7w83" + "partner":"7ocj" }, { "sim":50.0, - "partner":"7ocj" + "partner":"7w83" }, { "sim":50.0, @@ -646624,11 +649314,11 @@ }, { "sim":50.0, - "partner":"3tjo" + "partner":"7bez" }, { "sim":50.0, - "partner":"7bez" + "partner":"3tjo" }, { "sim":50.0, @@ -646644,15 +649334,15 @@ }, { "sim":50.0, - "partner":"6z0x" + "partner":"6z0y" }, { "sim":50.0, - "partner":"6z0y" + "partner":"6z0e" }, { "sim":50.0, - "partner":"6z0e" + "partner":"6z0x" }, { "sim":50.0, @@ -646688,31 +649378,31 @@ }, { "sim":50.0, - "partner":"6o98" + "partner":"7jh2" }, { "sim":50.0, - "partner":"7d9v" + "partner":"7d8h" }, { "sim":50.0, - "partner":"7d8p" + "partner":"6bn6" }, { "sim":50.0, - "partner":"7jh2" + "partner":"6xfv" }, { "sim":50.0, - "partner":"7d8h" + "partner":"7d9v" }, { "sim":50.0, - "partner":"6bn6" + "partner":"6o98" }, { "sim":50.0, - "partner":"6xfv" + "partner":"7d8p" }, { "sim":50.0, @@ -646814,14 +649504,6 @@ "sim":50.0, "partner":"7dbs" }, - { - "sim":50.0, - "partner":"7kqj" - }, - { - "sim":50.0, - "partner":"6vqf" - }, { "sim":50.0, "partner":"7kxd" @@ -646868,12 +649550,20 @@ }, { "sim":50.0, - "partner":"4rni" + "partner":"6vqf" + }, + { + "sim":50.0, + "partner":"7kqj" }, { "sim":50.0, "partner":"4rnj" }, + { + "sim":50.0, + "partner":"4rni" + }, { "sim":50.0, "partner":"5ldb" @@ -646914,10 +649604,6 @@ "sim":50.0, "partner":"6zzt" }, - { - "sim":50.0, - "partner":"4bwa" - }, { "sim":50.0, "partner":"2zim" @@ -646998,6 +649684,10 @@ "sim":50.0, "partner":"4bw9" }, + { + "sim":50.0, + "partner":"4bwa" + }, { "sim":50.0, "partner":"6y61" @@ -647030,10 +649720,6 @@ "sim":50.0, "partner":"2oz5" }, - { - "sim":50.0, - "partner":"4rtl" - }, { "sim":50.0, "partner":"4rtm" @@ -647074,6 +649760,10 @@ "sim":50.0, "partner":"4rtk" }, + { + "sim":50.0, + "partner":"4rtl" + }, { "sim":50.0, "partner":"5teu" @@ -647104,24 +649794,20 @@ }, { "sim":50.0, - "partner":"1g8o" + "partner":"3zgd" }, { "sim":50.0, - "partner":"1fg5" + "partner":"1g8o" }, { "sim":50.0, - "partner":"3zgd" + "partner":"1fg5" }, { "sim":50.0, "partner":"1g93" }, - { - "sim":50.0, - "partner":"3g3d" - }, { "sim":50.0, "partner":"3bvj" @@ -647146,6 +649832,10 @@ "sim":50.0, "partner":"4hkp" }, + { + "sim":50.0, + "partner":"3g3d" + }, { "sim":50.0, "partner":"7e4m" @@ -647226,14 +649916,6 @@ "sim":50.0, "partner":"7r2e" }, - { - "sim":50.0, - "partner":"4h2w" - }, - { - "sim":50.0, - "partner":"3mey" - }, { "sim":50.0, "partner":"4h2x" @@ -647268,20 +649950,24 @@ }, { "sim":50.0, - "partner":"4l3f" + "partner":"4h2w" }, { "sim":50.0, - "partner":"7cm8" + "partner":"3mey" }, { "sim":50.0, - "partner":"7djq" + "partner":"4l3f" }, { "sim":50.0, "partner":"7c35" }, + { + "sim":50.0, + "partner":"7ewo" + }, { "sim":50.0, "partner":"6aif" @@ -647296,7 +649982,7 @@ }, { "sim":50.0, - "partner":"7ewo" + "partner":"7cm8" }, { "sim":50.0, @@ -647304,19 +649990,19 @@ }, { "sim":50.0, - "partner":"7cxs" + "partner":"7djq" }, { "sim":50.0, - "partner":"7cxu" + "partner":"7cxs" }, { "sim":50.0, - "partner":"7cxv" + "partner":"7cxu" }, { "sim":50.0, - "partner":"2ikf" + "partner":"7cxv" }, { "sim":50.0, @@ -647348,11 +650034,7 @@ }, { "sim":50.0, - "partner":"1x19" - }, - { - "sim":50.0, - "partner":"1x1a" + "partner":"2ikf" }, { "sim":50.0, @@ -647420,19 +650102,23 @@ }, { "sim":50.0, - "partner":"5ysz" + "partner":"1x19" }, { "sim":50.0, - "partner":"6clw" + "partner":"1x1a" }, { "sim":50.0, - "partner":"6clx" + "partner":"5ysz" }, { "sim":50.0, - "partner":"4m1i" + "partner":"6clw" + }, + { + "sim":50.0, + "partner":"6clx" }, { "sim":50.0, @@ -647446,6 +650132,10 @@ "sim":50.0, "partner":"4m1h" }, + { + "sim":50.0, + "partner":"4m1i" + }, { "sim":50.0, "partner":"1si7" @@ -647462,10 +650152,6 @@ "sim":50.0, "partner":"6rfo" }, - { - "sim":50.0, - "partner":"2iua" - }, { "sim":50.0, "partner":"2iu8" @@ -647476,15 +650162,15 @@ }, { "sim":50.0, - "partner":"2nqo" + "partner":"2iua" }, { "sim":50.0, - "partner":"6rfp" + "partner":"2nqo" }, { "sim":50.0, - "partner":"6put" + "partner":"6rfp" }, { "sim":50.0, @@ -647498,21 +650184,17 @@ "sim":50.0, "partner":"6v3k" }, - { - "sim":50.0, - "partner":"5u1c" - }, { "sim":50.0, "partner":"6puz" }, { "sim":50.0, - "partner":"4q3r" + "partner":"5u1c" }, { "sim":50.0, - "partner":"4q42" + "partner":"6put" }, { "sim":50.0, @@ -647548,15 +650230,19 @@ }, { "sim":50.0, - "partner":"5j8x" + "partner":"4q3r" }, { "sim":50.0, - "partner":"6voy" + "partner":"4q42" }, { "sim":50.0, - "partner":"7dib" + "partner":"5j8x" + }, + { + "sim":50.0, + "partner":"6voy" }, { "sim":50.0, @@ -647566,13 +650252,17 @@ "sim":50.0, "partner":"3n3k" }, + { + "sim":50.0, + "partner":"6ha9" + }, { "sim":50.0, "partner":"5oyc" }, { "sim":50.0, - "partner":"6ha9" + "partner":"6haa" }, { "sim":50.0, @@ -647580,11 +650270,11 @@ }, { "sim":50.0, - "partner":"6haa" + "partner":"5oye" }, { "sim":50.0, - "partner":"5oye" + "partner":"7dib" }, { "sim":50.0, @@ -647608,16 +650298,20 @@ }, { "sim":50.0, - "partner":"8a6w" + "partner":"8s53" }, { "sim":50.0, - "partner":"5xw2" + "partner":"8a6w" }, { "sim":50.0, "partner":"4e2p" }, + { + "sim":50.0, + "partner":"5xw2" + }, { "sim":50.0, "partner":"7ljh" @@ -647642,14 +650336,6 @@ "sim":50.0, "partner":"2wio" }, - { - "sim":50.0, - "partner":"6j87" - }, - { - "sim":50.0, - "partner":"6j88" - }, { "sim":50.0, "partner":"5y0n" @@ -647664,11 +650350,11 @@ }, { "sim":50.0, - "partner":"2ca0" + "partner":"6j87" }, { "sim":50.0, - "partner":"4b7s" + "partner":"6j88" }, { "sim":50.0, @@ -647718,6 +650404,14 @@ "sim":50.0, "partner":"4umz" }, + { + "sim":50.0, + "partner":"2ca0" + }, + { + "sim":50.0, + "partner":"4b7s" + }, { "sim":50.0, "partner":"2yhg" @@ -647732,15 +650426,15 @@ }, { "sim":50.0, - "partner":"7xbn" + "partner":"7xbm" }, { "sim":50.0, - "partner":"7xbo" + "partner":"7xbn" }, { "sim":50.0, - "partner":"7xbm" + "partner":"7xbo" }, { "sim":50.0, @@ -647768,28 +650462,12 @@ }, { "sim":50.0, - "partner":"4wya" - }, - { - "sim":50.0, - "partner":"4wyf" - }, - { - "sim":50.0, - "partner":"4cxq" - }, - { - "sim":50.0, - "partner":"5kgs" + "partner":"4cxr" }, { "sim":50.0, "partner":"4wyg" }, - { - "sim":50.0, - "partner":"4cxr" - }, { "sim":50.0, "partner":"4xjl" @@ -647854,25 +650532,37 @@ "sim":50.0, "partner":"3tfu" }, + { + "sim":50.0, + "partner":"4wya" + }, { "sim":50.0, "partner":"4wye" }, { "sim":50.0, - "partner":"5tnu" + "partner":"4wyf" }, { "sim":50.0, - "partner":"6p4o" + "partner":"4cxq" }, { "sim":50.0, - "partner":"2zfn" + "partner":"5kgs" }, { "sim":50.0, - "partner":"7tfc" + "partner":"5tnu" + }, + { + "sim":50.0, + "partner":"6p4o" + }, + { + "sim":50.0, + "partner":"2zfn" }, { "sim":50.0, @@ -647884,7 +650574,7 @@ }, { "sim":50.0, - "partner":"4gt2" + "partner":"7tfc" }, { "sim":50.0, @@ -647896,15 +650586,11 @@ }, { "sim":50.0, - "partner":"5y9h" - }, - { - "sim":50.0, - "partner":"6mlh" + "partner":"4gt2" }, { "sim":50.0, - "partner":"6mlw" + "partner":"5y9h" }, { "sim":50.0, @@ -647932,11 +650618,15 @@ }, { "sim":50.0, - "partner":"6j0u" + "partner":"6mlh" }, { "sim":50.0, - "partner":"6vy9" + "partner":"6mlw" + }, + { + "sim":50.0, + "partner":"6j0u" }, { "sim":50.0, @@ -647950,6 +650640,10 @@ "sim":50.0, "partner":"5xix" }, + { + "sim":50.0, + "partner":"6vy9" + }, { "sim":50.0, "partner":"4kc7" @@ -648084,15 +650778,15 @@ }, { "sim":50.0, - "partner":"6qu3" + "partner":"6qu4" }, { "sim":50.0, - "partner":"6qu4" + "partner":"6qu5" }, { "sim":50.0, - "partner":"6qu5" + "partner":"6qu3" }, { "sim":50.0, @@ -648108,15 +650802,15 @@ }, { "sim":50.0, - "partner":"5kdn" + "partner":"5kds" }, { "sim":50.0, - "partner":"5kds" + "partner":"5kdu" }, { "sim":50.0, - "partner":"5kdu" + "partner":"5kdn" }, { "sim":50.0, @@ -648148,15 +650842,15 @@ }, { "sim":50.0, - "partner":"2vbg" + "partner":"3hx6" }, { "sim":50.0, - "partner":"3hx6" + "partner":"2vbf" }, { "sim":50.0, - "partner":"2vbf" + "partner":"2vbg" }, { "sim":50.0, @@ -648180,15 +650874,15 @@ }, { "sim":50.0, - "partner":"5tsh" + "partner":"6olj" }, { "sim":50.0, - "partner":"6olj" + "partner":"5tsg" }, { "sim":50.0, - "partner":"5tsg" + "partner":"5tsh" }, { "sim":50.0, @@ -648292,15 +650986,15 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"6edz" }, { "sim":50.0, - "partner":"6edz" + "partner":"6ee1" }, { "sim":50.0, - "partner":"6ee1" + "partner":"6edw" }, { "sim":50.0, @@ -648460,10 +651154,10 @@ ], "subtitle":"Ancestral petase 35_442 mutant e27q", "tags":[ - "petase", "pet", - "hydrolase", "plastic degradation", + "petase", + "hydrolase", "ancestral sequence reconstruction" ], "keywords":[ @@ -648533,11 +651227,11 @@ }, { "sim":51.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":51.0, - "partner":"8w08" + "partner":"8v0a" }, { "sim":50.0, @@ -648553,11 +651247,11 @@ }, { "sim":50.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":50.0, - "partner":"8w05" + "partner":"8w06" } ], "seq_thr_sim_natural":[ @@ -648599,11 +651293,11 @@ }, { "sim":412.0, - "partner":"7xtu" + "partner":"7xtv" }, { "sim":412.0, - "partner":"7xtv" + "partner":"7xtu" }, { "sim":412.0, @@ -648643,11 +651337,11 @@ }, { "sim":397.0, - "partner":"7e31" + "partner":"7w69" }, { "sim":397.0, - "partner":"7w69" + "partner":"7e31" }, { "sim":397.0, @@ -648657,10 +651351,6 @@ "sim":396.0, "partner":"7nei" }, - { - "sim":395.0, - "partner":"7e30" - }, { "sim":395.0, "partner":"7cuv" @@ -648673,6 +651363,10 @@ "sim":395.0, "partner":"7w6o" }, + { + "sim":395.0, + "partner":"7e30" + }, { "sim":395.0, "partner":"7w6q" @@ -648723,15 +651417,15 @@ }, { "sim":379.0, - "partner":"7cts" + "partner":"8ibl" }, { "sim":379.0, - "partner":"8ibl" + "partner":"8ibm" }, { "sim":379.0, - "partner":"8ibm" + "partner":"7cts" }, { "sim":378.0, @@ -648839,19 +651533,19 @@ }, { "sim":303.0, - "partner":"8h5l" + "partner":"5xjh" }, { "sim":303.0, - "partner":"6kuq" + "partner":"6kuo" }, { "sim":303.0, - "partner":"5xjh" + "partner":"8h5l" }, { "sim":303.0, - "partner":"6kuo" + "partner":"6kuq" }, { "sim":301.0, @@ -648979,23 +651673,23 @@ }, { "sim":272.0, - "partner":"6eqd" + "partner":"6eqg" }, { "sim":272.0, - "partner":"6eqe" + "partner":"6eqh" }, { "sim":272.0, - "partner":"6eqf" + "partner":"6eqd" }, { "sim":272.0, - "partner":"6eqg" + "partner":"6eqe" }, { "sim":272.0, - "partner":"6eqh" + "partner":"6eqf" }, { "sim":271.0, @@ -649057,6 +651751,26 @@ "sim":251.0, "partner":"8spk" }, + { + "sim":243.0, + "partner":"8ytu" + }, + { + "sim":243.0, + "partner":"8ytv" + }, + { + "sim":223.0, + "partner":"8yty" + }, + { + "sim":222.0, + "partner":"8ytw" + }, + { + "sim":218.0, + "partner":"8ytz" + }, { "sim":141.0, "partner":"7pzj" @@ -649069,10 +651783,6 @@ "sim":73.0, "partner":"2fx5" }, - { - "sim":64.0, - "partner":"4ke6" - }, { "sim":64.0, "partner":"4ke7" @@ -649093,6 +651803,10 @@ "sim":64.0, "partner":"3rli" }, + { + "sim":64.0, + "partner":"4ke6" + }, { "sim":61.0, "partner":"4ke9" @@ -649155,51 +651869,51 @@ }, { "sim":57.0, - "partner":"7q2b" + "partner":"7q2f" }, { "sim":57.0, - "partner":"3ha3" + "partner":"7q2g" }, { "sim":57.0, - "partner":"7q2c" + "partner":"7q2h" }, { "sim":57.0, - "partner":"7q2d" + "partner":"3ha5" }, { "sim":57.0, - "partner":"7q2e" + "partner":"2fk7" }, { "sim":57.0, - "partner":"7q2f" + "partner":"2fk8" }, { "sim":57.0, - "partner":"7q2g" + "partner":"3ha7" }, { "sim":57.0, - "partner":"7q2h" + "partner":"7q2b" }, { "sim":57.0, - "partner":"3ha5" + "partner":"7q2c" }, { "sim":57.0, - "partner":"2fk7" + "partner":"3ha3" }, { "sim":57.0, - "partner":"2fk8" + "partner":"7q2d" }, { "sim":57.0, - "partner":"3ha7" + "partner":"7q2e" }, { "sim":57.0, @@ -649221,10 +651935,6 @@ "sim":57.0, "partner":"7p1o" }, - { - "sim":57.0, - "partner":"4lre" - }, { "sim":57.0, "partner":"4lrf" @@ -649259,11 +651969,11 @@ }, { "sim":57.0, - "partner":"7ozc" + "partner":"4lre" }, { "sim":57.0, - "partner":"7w1c" + "partner":"7ozc" }, { "sim":57.0, @@ -649273,6 +651983,10 @@ "sim":57.0, "partner":"7w1e" }, + { + "sim":57.0, + "partner":"7w1c" + }, { "sim":56.0, "partner":"2rv8" @@ -649307,11 +652021,11 @@ }, { "sim":55.0, - "partner":"3kwe" + "partner":"3kwd" }, { "sim":55.0, - "partner":"3kwd" + "partner":"3kwe" }, { "sim":55.0, @@ -649385,10 +652099,6 @@ "sim":55.0, "partner":"4y0k" }, - { - "sim":55.0, - "partner":"4tm4" - }, { "sim":55.0, "partner":"4tlx" @@ -649409,6 +652119,10 @@ "sim":55.0, "partner":"4tm3" }, + { + "sim":55.0, + "partner":"4tm4" + }, { "sim":55.0, "partner":"3zlf" @@ -649481,14 +652195,6 @@ "sim":54.0, "partner":"4n57" }, - { - "sim":54.0, - "partner":"2nq6" - }, - { - "sim":54.0, - "partner":"2nq7" - }, { "sim":54.0, "partner":"2b3k" @@ -649531,7 +652237,11 @@ }, { "sim":54.0, - "partner":"2o0h" + "partner":"2nq6" + }, + { + "sim":54.0, + "partner":"2nq7" }, { "sim":54.0, @@ -649543,19 +652253,19 @@ }, { "sim":54.0, - "partner":"2o1b" + "partner":"2o0h" }, { "sim":54.0, - "partner":"4bko" + "partner":"2o1b" }, { "sim":54.0, - "partner":"5xpj" + "partner":"4bko" }, { "sim":54.0, - "partner":"5dvi" + "partner":"5xpj" }, { "sim":54.0, @@ -649567,7 +652277,7 @@ }, { "sim":54.0, - "partner":"5cu7" + "partner":"5dvi" }, { "sim":54.0, @@ -649583,27 +652293,31 @@ }, { "sim":54.0, - "partner":"6ry0" + "partner":"5cu7" }, { "sim":54.0, - "partner":"6ry1" + "partner":"6ry5" }, { "sim":54.0, - "partner":"6ry2" + "partner":"6ry6" }, { "sim":54.0, - "partner":"6ry5" + "partner":"6ry7" }, { "sim":54.0, - "partner":"6ry6" + "partner":"6ry0" }, { "sim":54.0, - "partner":"6ry7" + "partner":"6ry1" + }, + { + "sim":54.0, + "partner":"6ry2" }, { "sim":54.0, @@ -649729,10 +652443,6 @@ "sim":53.0, "partner":"2y78" }, - { - "sim":53.0, - "partner":"6ebc" - }, { "sim":53.0, "partner":"6ebd" @@ -649745,6 +652455,10 @@ "sim":53.0, "partner":"6eb4" }, + { + "sim":53.0, + "partner":"6ebc" + }, { "sim":53.0, "partner":"7st8" @@ -649783,15 +652497,11 @@ }, { "sim":53.0, - "partner":"6pj9" - }, - { - "sim":53.0, - "partner":"6pja" + "partner":"6pjp" }, { "sim":53.0, - "partner":"6pjp" + "partner":"6pjq" }, { "sim":53.0, @@ -649799,11 +652509,11 @@ }, { "sim":53.0, - "partner":"6pjq" + "partner":"6pjr" }, { "sim":53.0, - "partner":"6pjr" + "partner":"6pju" }, { "sim":53.0, @@ -649813,10 +652523,6 @@ "sim":53.0, "partner":"5f5d" }, - { - "sim":53.0, - "partner":"6pju" - }, { "sim":53.0, "partner":"4njp" @@ -649839,15 +652545,19 @@ }, { "sim":53.0, - "partner":"5f5j" + "partner":"6pj5" }, { "sim":53.0, - "partner":"6pj5" + "partner":"6pj7" }, { "sim":53.0, - "partner":"6pj7" + "partner":"5f5j" + }, + { + "sim":53.0, + "partner":"6pj8" }, { "sim":53.0, @@ -649855,7 +652565,11 @@ }, { "sim":53.0, - "partner":"6pj8" + "partner":"6pj9" + }, + { + "sim":53.0, + "partner":"6pja" }, { "sim":53.0, @@ -649875,11 +652589,11 @@ }, { "sim":53.0, - "partner":"6ey1" + "partner":"6f0w" }, { "sim":53.0, - "partner":"6f0w" + "partner":"6ey1" }, { "sim":53.0, @@ -649895,23 +652609,23 @@ }, { "sim":53.0, - "partner":"6ub4" + "partner":"6ub2" }, { "sim":53.0, - "partner":"6ub5" + "partner":"6ub3" }, { "sim":53.0, - "partner":"6ub6" + "partner":"6ub4" }, { "sim":53.0, - "partner":"6ub2" + "partner":"6ub5" }, { "sim":53.0, - "partner":"6ub3" + "partner":"6ub6" }, { "sim":53.0, @@ -649937,10 +652651,6 @@ "sim":53.0, "partner":"6itx" }, - { - "sim":53.0, - "partner":"4pgc" - }, { "sim":53.0, "partner":"4pgd" @@ -649959,7 +652669,7 @@ }, { "sim":53.0, - "partner":"3s3h" + "partner":"4pgc" }, { "sim":53.0, @@ -649973,6 +652683,10 @@ "sim":53.0, "partner":"3s3f" }, + { + "sim":53.0, + "partner":"3s3h" + }, { "sim":53.0, "partner":"6xtu" @@ -649995,28 +652709,24 @@ }, { "sim":53.0, - "partner":"7q4u" + "partner":"7zf2" }, { "sim":53.0, - "partner":"7q59" + "partner":"7q4u" }, { "sim":53.0, - "partner":"7pp4" + "partner":"7q59" }, { "sim":53.0, - "partner":"7zf2" + "partner":"7pp4" }, { "sim":53.0, "partner":"4xq6" }, - { - "sim":53.0, - "partner":"7ajm" - }, { "sim":53.0, "partner":"7a4r" @@ -650031,23 +652741,7 @@ }, { "sim":53.0, - "partner":"7a53" - }, - { - "sim":53.0, - "partner":"7ajw" - }, - { - "sim":53.0, - "partner":"7akb" - }, - { - "sim":53.0, - "partner":"7ajy" - }, - { - "sim":53.0, - "partner":"7a5l" + "partner":"7ajm" }, { "sim":53.0, @@ -650109,10 +652803,30 @@ "sim":53.0, "partner":"7aka" }, + { + "sim":53.0, + "partner":"7a53" + }, { "sim":53.0, "partner":"7akl" }, + { + "sim":53.0, + "partner":"7ajw" + }, + { + "sim":53.0, + "partner":"7akb" + }, + { + "sim":53.0, + "partner":"7ajy" + }, + { + "sim":53.0, + "partner":"7a5l" + }, { "sim":53.0, "partner":"3wcg" @@ -650175,11 +652889,11 @@ }, { "sim":53.0, - "partner":"3i68" + "partner":"6u76" }, { "sim":53.0, - "partner":"6u76" + "partner":"3i68" }, { "sim":53.0, @@ -650195,15 +652909,15 @@ }, { "sim":53.0, - "partner":"7cl7" + "partner":"6l69" }, { "sim":53.0, - "partner":"7cl8" + "partner":"7cl7" }, { "sim":53.0, - "partner":"6l69" + "partner":"7cl8" }, { "sim":53.0, @@ -650305,10 +653019,6 @@ "sim":53.0, "partner":"8r72" }, - { - "sim":53.0, - "partner":"2fw3" - }, { "sim":53.0, "partner":"4ep9" @@ -650329,6 +653039,10 @@ "sim":53.0, "partner":"4eph" }, + { + "sim":53.0, + "partner":"2fw3" + }, { "sim":53.0, "partner":"7xsy" @@ -650353,10 +653067,6 @@ "sim":53.0, "partner":"5x7h" }, - { - "sim":53.0, - "partner":"5y1h" - }, { "sim":53.0, "partner":"5y1k" @@ -650403,15 +653113,19 @@ }, { "sim":53.0, - "partner":"6tsh" + "partner":"5y1h" }, { "sim":53.0, - "partner":"6tte" + "partner":"6tsk" }, { "sim":53.0, - "partner":"6tsk" + "partner":"6tsh" + }, + { + "sim":53.0, + "partner":"6tte" }, { "sim":52.0, @@ -650483,11 +653197,11 @@ }, { "sim":52.0, - "partner":"1wc6" + "partner":"1wc1" }, { "sim":52.0, - "partner":"1wc1" + "partner":"1wc6" }, { "sim":52.0, @@ -650495,16 +653209,12 @@ }, { "sim":52.0, - "partner":"7o2t" + "partner":"6z17" }, { "sim":52.0, "partner":"7o2u" }, - { - "sim":52.0, - "partner":"6z17" - }, { "sim":52.0, "partner":"6yz3" @@ -650521,6 +653231,10 @@ "sim":52.0, "partner":"6z5k" }, + { + "sim":52.0, + "partner":"7o2t" + }, { "sim":52.0, "partner":"1zw9" @@ -650541,10 +653255,6 @@ "sim":52.0, "partner":"3c0e" }, - { - "sim":52.0, - "partner":"3la7" - }, { "sim":52.0, "partner":"3la2" @@ -650557,6 +653267,10 @@ "sim":52.0, "partner":"3qc1" }, + { + "sim":52.0, + "partner":"3la7" + }, { "sim":52.0, "partner":"6kdr" @@ -650593,14 +653307,6 @@ "sim":52.0, "partner":"8bat" }, - { - "sim":52.0, - "partner":"5ds3" - }, - { - "sim":52.0, - "partner":"6bhv" - }, { "sim":52.0, "partner":"6ntu" @@ -650629,6 +653335,14 @@ "sim":52.0, "partner":"6nrj" }, + { + "sim":52.0, + "partner":"6bhv" + }, + { + "sim":52.0, + "partner":"5ds3" + }, { "sim":52.0, "partner":"6dli" @@ -650677,17 +653391,13 @@ "sim":52.0, "partner":"3utn" }, - { - "sim":52.0, - "partner":"7btm" - }, { "sim":52.0, "partner":"7bsx" }, { "sim":52.0, - "partner":"2pt0" + "partner":"7btm" }, { "sim":52.0, @@ -650709,6 +653419,10 @@ "sim":52.0, "partner":"2psz" }, + { + "sim":52.0, + "partner":"2pt0" + }, { "sim":52.0, "partner":"3pdc" @@ -650723,15 +653437,15 @@ }, { "sim":52.0, - "partner":"5eeg" + "partner":"5eeh" }, { "sim":52.0, - "partner":"5jr3" + "partner":"5eeg" }, { "sim":52.0, - "partner":"5eeh" + "partner":"5jr3" }, { "sim":52.0, @@ -650799,11 +653513,11 @@ }, { "sim":52.0, - "partner":"7r39" + "partner":"3c48" }, { "sim":52.0, - "partner":"3c48" + "partner":"7r39" }, { "sim":52.0, @@ -650813,21 +653527,17 @@ "sim":52.0, "partner":"5h9y" }, - { - "sim":52.0, - "partner":"8il0" - }, { "sim":52.0, "partner":"8ila" }, { "sim":52.0, - "partner":"4zm3" + "partner":"8il0" }, { "sim":52.0, - "partner":"4acg" + "partner":"4zm3" }, { "sim":52.0, @@ -650843,11 +653553,11 @@ }, { "sim":52.0, - "partner":"2fwr" + "partner":"4acg" }, { "sim":52.0, - "partner":"6rk2" + "partner":"2fwr" }, { "sim":52.0, @@ -650861,6 +653571,10 @@ "sim":52.0, "partner":"6rjm" }, + { + "sim":52.0, + "partner":"6rk2" + }, { "sim":52.0, "partner":"6yyh" @@ -650885,26 +653599,18 @@ "sim":52.0, "partner":"6ms3" }, - { - "sim":52.0, - "partner":"4bzc" - }, { "sim":52.0, "partner":"4qg1" }, { "sim":52.0, - "partner":"6dwk" + "partner":"6dwd" }, { "sim":52.0, "partner":"4qg2" }, - { - "sim":52.0, - "partner":"6dwd" - }, { "sim":52.0, "partner":"7s2y" @@ -650953,6 +653659,14 @@ "sim":52.0, "partner":"4qg0" }, + { + "sim":52.0, + "partner":"6dwk" + }, + { + "sim":52.0, + "partner":"4bzc" + }, { "sim":52.0, "partner":"3u9s" @@ -650999,27 +653713,27 @@ }, { "sim":52.0, - "partner":"4j3t" + "partner":"4j3v" }, { "sim":52.0, - "partner":"4j3u" + "partner":"4j3w" }, { "sim":52.0, - "partner":"4j3v" + "partner":"4j3x" }, { "sim":52.0, - "partner":"4j3w" + "partner":"4j3s" }, { "sim":52.0, - "partner":"4j3x" + "partner":"4j3t" }, { "sim":52.0, - "partner":"4j3s" + "partner":"4j3u" }, { "sim":52.0, @@ -651161,10 +653875,6 @@ "sim":51.0, "partner":"2vvy" }, - { - "sim":51.0, - "partner":"5c7p" - }, { "sim":51.0, "partner":"7f0y" @@ -651185,6 +653895,10 @@ "sim":51.0, "partner":"7f11" }, + { + "sim":51.0, + "partner":"5c7p" + }, { "sim":51.0, "partner":"8hlg" @@ -651203,11 +653917,11 @@ }, { "sim":51.0, - "partner":"5k24" + "partner":"5k22" }, { "sim":51.0, - "partner":"5k22" + "partner":"5k24" }, { "sim":51.0, @@ -651281,10 +653995,6 @@ "sim":51.0, "partner":"7r1n" }, - { - "sim":51.0, - "partner":"5l9k" - }, { "sim":51.0, "partner":"5l9q" @@ -651297,6 +654007,10 @@ "sim":51.0, "partner":"5lbp" }, + { + "sim":51.0, + "partner":"5l9k" + }, { "sim":51.0, "partner":"6erd" @@ -651323,27 +654037,27 @@ }, { "sim":51.0, - "partner":"8b9b" + "partner":"8b9a" }, { "sim":51.0, - "partner":"6skl" + "partner":"8b9c" }, { "sim":51.0, - "partner":"8b9a" + "partner":"8b9b" }, { "sim":51.0, - "partner":"8b9c" + "partner":"6skl" }, { "sim":51.0, - "partner":"3oci" + "partner":"3oc3" }, { "sim":51.0, - "partner":"3oc3" + "partner":"3oci" }, { "sim":51.0, @@ -651407,27 +654121,27 @@ }, { "sim":51.0, - "partner":"7mnq" + "partner":"7mns" }, { "sim":51.0, - "partner":"7mnr" + "partner":"7mnt" }, { "sim":51.0, - "partner":"7mns" + "partner":"7mnu" }, { "sim":51.0, - "partner":"7mnt" + "partner":"7mnv" }, { "sim":51.0, - "partner":"7mnu" + "partner":"7mnq" }, { "sim":51.0, - "partner":"7mnv" + "partner":"7mnr" }, { "sim":51.0, @@ -651505,21 +654219,17 @@ "sim":51.0, "partner":"4dmm" }, - { - "sim":51.0, - "partner":"6hxo" - }, { "sim":51.0, "partner":"6hxn" }, { "sim":51.0, - "partner":"4jlj" + "partner":"6hxo" }, { "sim":51.0, - "partner":"7zi1" + "partner":"4jlj" }, { "sim":51.0, @@ -651527,16 +654237,12 @@ }, { "sim":51.0, - "partner":"7zi2" + "partner":"7zi3" }, { "sim":51.0, "partner":"4jlk" }, - { - "sim":51.0, - "partner":"7zi3" - }, { "sim":51.0, "partner":"2no6" @@ -651601,13 +654307,17 @@ "sim":51.0, "partner":"2qro" }, + { + "sim":51.0, + "partner":"7zi5" + }, { "sim":51.0, "partner":"4q1f" }, { "sim":51.0, - "partner":"7zi5" + "partner":"7zi6" }, { "sim":51.0, @@ -651615,11 +654325,11 @@ }, { "sim":51.0, - "partner":"7zi6" + "partner":"7zi7" }, { "sim":51.0, - "partner":"7zi7" + "partner":"7zi8" }, { "sim":51.0, @@ -651627,7 +654337,7 @@ }, { "sim":51.0, - "partner":"7zi8" + "partner":"7zi9" }, { "sim":51.0, @@ -651635,15 +654345,19 @@ }, { "sim":51.0, - "partner":"7zi9" + "partner":"7zia" }, { "sim":51.0, - "partner":"7zia" + "partner":"7zib" }, { "sim":51.0, - "partner":"7zib" + "partner":"7zi1" + }, + { + "sim":51.0, + "partner":"7zi2" }, { "sim":51.0, @@ -651659,35 +654373,35 @@ }, { "sim":51.0, - "partner":"6t2p" + "partner":"6uaw" }, { "sim":51.0, - "partner":"6t2q" + "partner":"6t2o" }, { "sim":51.0, - "partner":"6uaw" + "partner":"6t2p" }, { "sim":51.0, - "partner":"6t2o" + "partner":"6t2q" }, { "sim":51.0, - "partner":"7a61" + "partner":"8rwq" }, { "sim":51.0, - "partner":"5uj3" + "partner":"6mnp" }, { "sim":51.0, - "partner":"5uj4" + "partner":"8rwr" }, { "sim":51.0, - "partner":"6mnp" + "partner":"5uj3" }, { "sim":51.0, @@ -651695,7 +654409,11 @@ }, { "sim":51.0, - "partner":"5ul8" + "partner":"8rws" + }, + { + "sim":51.0, + "partner":"5uj4" }, { "sim":51.0, @@ -651709,6 +654427,10 @@ "sim":51.0, "partner":"6d17" }, + { + "sim":51.0, + "partner":"5ul8" + }, { "sim":51.0, "partner":"6d18" @@ -651767,15 +654489,15 @@ }, { "sim":51.0, - "partner":"8rwq" + "partner":"6mey" }, { "sim":51.0, - "partner":"6mey" + "partner":"6v1j" }, { "sim":51.0, - "partner":"6v1j" + "partner":"8aki" }, { "sim":51.0, @@ -651783,7 +654505,7 @@ }, { "sim":51.0, - "partner":"8aki" + "partner":"8akj" }, { "sim":51.0, @@ -651795,16 +654517,12 @@ }, { "sim":51.0, - "partner":"8akj" + "partner":"8akk" }, { "sim":51.0, "partner":"6td1" }, - { - "sim":51.0, - "partner":"8akk" - }, { "sim":51.0, "partner":"8akl" @@ -651825,6 +654543,18 @@ "sim":51.0, "partner":"4cp2" }, + { + "sim":51.0, + "partner":"7a61" + }, + { + "sim":51.0, + "partner":"8rwo" + }, + { + "sim":51.0, + "partner":"8rwp" + }, { "sim":51.0, "partner":"4hu3" @@ -651855,35 +654585,35 @@ }, { "sim":51.0, - "partner":"8wlb" + "partner":"8wl5" }, { "sim":51.0, - "partner":"6vlx" + "partner":"8wl7" }, { "sim":51.0, - "partner":"6vly" + "partner":"8wl9" }, { "sim":51.0, - "partner":"8wl5" + "partner":"8wlb" }, { "sim":51.0, - "partner":"8wl7" + "partner":"6vlx" }, { "sim":51.0, - "partner":"8wl9" + "partner":"6vly" }, { "sim":51.0, - "partner":"6y5x" + "partner":"6y5y" }, { "sim":51.0, - "partner":"6y5y" + "partner":"6y5x" }, { "sim":51.0, @@ -651893,10 +654623,6 @@ "sim":51.0, "partner":"6oid" }, - { - "sim":51.0, - "partner":"3aio" - }, { "sim":51.0, "partner":"3aik" @@ -651917,6 +654643,10 @@ "sim":51.0, "partner":"3ain" }, + { + "sim":51.0, + "partner":"3aio" + }, { "sim":51.0, "partner":"3h7r" @@ -651941,14 +654671,6 @@ "sim":51.0, "partner":"6kxh" }, - { - "sim":51.0, - "partner":"5gg5" - }, - { - "sim":51.0, - "partner":"5xd1" - }, { "sim":51.0, "partner":"5gg6" @@ -651963,27 +654685,27 @@ }, { "sim":51.0, - "partner":"5gg7" + "partner":"6m6y" }, { "sim":51.0, - "partner":"5xd4" + "partner":"5gg7" }, { "sim":51.0, - "partner":"5xd5" + "partner":"5xd4" }, { "sim":51.0, - "partner":"6m6y" + "partner":"6m65" }, { "sim":51.0, - "partner":"5gg8" + "partner":"5xd5" }, { "sim":51.0, - "partner":"6m65" + "partner":"5gg8" }, { "sim":51.0, @@ -652017,6 +654739,14 @@ "sim":51.0, "partner":"6m69" }, + { + "sim":51.0, + "partner":"5gg5" + }, + { + "sim":51.0, + "partner":"5xd1" + }, { "sim":51.0, "partner":"8bfr" @@ -652027,27 +654757,27 @@ }, { "sim":51.0, - "partner":"4mfj" + "partner":"4mfl" }, { "sim":51.0, - "partner":"4mfk" + "partner":"4mfp" }, { "sim":51.0, - "partner":"4mfl" + "partner":"4mfq" }, { "sim":51.0, - "partner":"6iix" + "partner":"4mfj" }, { "sim":51.0, - "partner":"4mfp" + "partner":"6iix" }, { "sim":51.0, - "partner":"4mfq" + "partner":"4mfk" }, { "sim":51.0, @@ -652123,43 +654853,43 @@ }, { "sim":51.0, - "partner":"4g2f" + "partner":"3dzq" }, { "sim":51.0, - "partner":"4gk3" + "partner":"4p5z" }, { "sim":51.0, - "partner":"4gk4" + "partner":"4twn" }, { "sim":51.0, - "partner":"4p5q" + "partner":"4two" }, { "sim":51.0, - "partner":"3dzq" + "partner":"4p4c" }, { "sim":51.0, - "partner":"4p5z" + "partner":"4gk2" }, { "sim":51.0, - "partner":"4twn" + "partner":"4g2f" }, { "sim":51.0, - "partner":"4two" + "partner":"4gk3" }, { "sim":51.0, - "partner":"4p4c" + "partner":"4gk4" }, { "sim":51.0, - "partner":"4gk2" + "partner":"4p5q" }, { "sim":51.0, @@ -652197,10 +654927,6 @@ "sim":51.0, "partner":"3dt1" }, - { - "sim":51.0, - "partner":"3skv" - }, { "sim":51.0, "partner":"4gmg" @@ -652215,11 +654941,11 @@ }, { "sim":51.0, - "partner":"7ct4" + "partner":"3skv" }, { "sim":51.0, - "partner":"5hxu" + "partner":"7ct4" }, { "sim":51.0, @@ -652227,23 +654953,19 @@ }, { "sim":51.0, - "partner":"5hxz" - }, - { - "sim":51.0, - "partner":"5hwe" + "partner":"8g5s" }, { "sim":51.0, - "partner":"8g5s" + "partner":"5hxz" }, { "sim":51.0, - "partner":"3dyh" + "partner":"5hwe" }, { "sim":51.0, - "partner":"4rxd" + "partner":"5hxu" }, { "sim":51.0, @@ -652287,19 +655009,19 @@ }, { "sim":51.0, - "partner":"6zgp" + "partner":"4rxd" }, { "sim":51.0, - "partner":"6y8j" + "partner":"3dyh" }, { "sim":51.0, - "partner":"6y9c" + "partner":"6y9d" }, { "sim":51.0, - "partner":"6y9d" + "partner":"6zgp" }, { "sim":51.0, @@ -652307,11 +655029,15 @@ }, { "sim":51.0, - "partner":"3bu7" + "partner":"6y8j" }, { "sim":51.0, - "partner":"5oyc" + "partner":"6y9c" + }, + { + "sim":51.0, + "partner":"3bu7" }, { "sim":51.0, @@ -652319,12 +655045,16 @@ }, { "sim":51.0, - "partner":"5oyd" + "partner":"5oyc" }, { "sim":51.0, "partner":"6haa" }, + { + "sim":51.0, + "partner":"5oyd" + }, { "sim":51.0, "partner":"5oye" @@ -652343,15 +655073,15 @@ }, { "sim":51.0, - "partner":"8bdq" + "partner":"6m7l" }, { "sim":51.0, - "partner":"6m7l" + "partner":"4zas" }, { "sim":51.0, - "partner":"4zas" + "partner":"8bdq" }, { "sim":51.0, @@ -652363,15 +655093,15 @@ }, { "sim":51.0, - "partner":"3wkr" + "partner":"3wks" }, { "sim":51.0, - "partner":"3wks" + "partner":"7xp7" }, { "sim":51.0, - "partner":"7xp7" + "partner":"3wkr" }, { "sim":51.0, @@ -652397,14 +655127,6 @@ "sim":51.0, "partner":"5y0o" }, - { - "sim":51.0, - "partner":"2ca0" - }, - { - "sim":51.0, - "partner":"4b7s" - }, { "sim":51.0, "partner":"2vz7" @@ -652449,6 +655171,14 @@ "sim":51.0, "partner":"4umz" }, + { + "sim":51.0, + "partner":"2ca0" + }, + { + "sim":51.0, + "partner":"4b7s" + }, { "sim":51.0, "partner":"5ysw" @@ -652459,15 +655189,15 @@ }, { "sim":51.0, - "partner":"7xbn" + "partner":"7xbm" }, { "sim":51.0, - "partner":"7xbo" + "partner":"7xbn" }, { "sim":51.0, - "partner":"7xbm" + "partner":"7xbo" }, { "sim":51.0, @@ -652479,19 +655209,27 @@ }, { "sim":51.0, - "partner":"4gt2" + "partner":"3e1h" }, { "sim":51.0, - "partner":"3e1h" + "partner":"8wn5" }, { "sim":51.0, - "partner":"3hzz" + "partner":"8wn6" }, { "sim":51.0, - "partner":"2wc4" + "partner":"8wna" + }, + { + "sim":51.0, + "partner":"4gt2" + }, + { + "sim":51.0, + "partner":"3hzz" }, { "sim":51.0, @@ -652605,21 +655343,25 @@ "sim":51.0, "partner":"1uz1" }, + { + "sim":51.0, + "partner":"2wc4" + }, { "sim":51.0, "partner":"6ksu" }, { "sim":51.0, - "partner":"5zxg" + "partner":"6ksv" }, { "sim":51.0, - "partner":"6a0j" + "partner":"5zxg" }, { "sim":51.0, - "partner":"6ksv" + "partner":"6a0j" }, { "sim":51.0, @@ -652677,10 +655419,6 @@ "sim":51.0, "partner":"5m1e" }, - { - "sim":51.0, - "partner":"2cj9" - }, { "sim":51.0, "partner":"2cja" @@ -652693,6 +655431,10 @@ "sim":51.0, "partner":"2cjb" }, + { + "sim":51.0, + "partner":"2cj9" + }, { "sim":51.0, "partner":"4k2x" @@ -652715,47 +655457,47 @@ }, { "sim":51.0, - "partner":"8aq3" + "partner":"7aci" }, { "sim":51.0, - "partner":"8aq4" + "partner":"8b0k" }, { "sim":51.0, - "partner":"7aci" + "partner":"8b0l" }, { "sim":51.0, - "partner":"8b0k" + "partner":"8b0m" }, { "sim":51.0, - "partner":"5n6h" + "partner":"8b0n" }, { "sim":51.0, - "partner":"8b0l" + "partner":"5n6h" }, { "sim":51.0, - "partner":"8b0m" + "partner":"8b0o" }, { "sim":51.0, - "partner":"8b0n" + "partner":"8b0p" }, { "sim":51.0, - "partner":"8b0o" + "partner":"5n6l" }, { "sim":51.0, - "partner":"8b0p" + "partner":"8aq3" }, { "sim":51.0, - "partner":"5n6l" + "partner":"8aq4" }, { "sim":51.0, @@ -652811,11 +655553,11 @@ }, { "sim":51.0, - "partner":"7jwf" + "partner":"7jw4" }, { "sim":51.0, - "partner":"7jw4" + "partner":"7jwf" }, { "sim":51.0, @@ -652849,10 +655591,6 @@ "sim":51.0, "partner":"6nff" }, - { - "sim":51.0, - "partner":"6jr8" - }, { "sim":51.0, "partner":"6jr6" @@ -652863,11 +655601,11 @@ }, { "sim":51.0, - "partner":"7c6o" + "partner":"6jr8" }, { "sim":51.0, - "partner":"6yt0" + "partner":"7c6o" }, { "sim":51.0, @@ -652885,6 +655623,10 @@ "sim":51.0, "partner":"6ytj" }, + { + "sim":51.0, + "partner":"6yt0" + }, { "sim":51.0, "partner":"2zxq" @@ -652917,10 +655659,6 @@ "sim":50.0, "partner":"2f09" }, - { - "sim":50.0, - "partner":"7vp1" - }, { "sim":50.0, "partner":"7vp2" @@ -652937,6 +655675,10 @@ "sim":50.0, "partner":"7vp4" }, + { + "sim":50.0, + "partner":"7vp1" + }, { "sim":50.0, "partner":"4h2s" @@ -652987,19 +655729,15 @@ }, { "sim":50.0, - "partner":"4hmr" - }, - { - "sim":50.0, - "partner":"7p4y" + "partner":"7p50" }, { "sim":50.0, - "partner":"7p50" + "partner":"7u0u" }, { "sim":50.0, - "partner":"7u0u" + "partner":"7p4y" }, { "sim":50.0, @@ -653011,7 +655749,7 @@ }, { "sim":50.0, - "partner":"6bev" + "partner":"4hmr" }, { "sim":50.0, @@ -653027,7 +655765,7 @@ }, { "sim":50.0, - "partner":"3vwb" + "partner":"6bev" }, { "sim":50.0, @@ -653037,6 +655775,10 @@ "sim":50.0, "partner":"3w3c" }, + { + "sim":50.0, + "partner":"3vwb" + }, { "sim":50.0, "partner":"6bbx" @@ -653171,19 +655913,19 @@ }, { "sim":50.0, - "partner":"1x24" + "partner":"4gzd" }, { "sim":50.0, - "partner":"4gzc" + "partner":"1zcl" }, { "sim":50.0, - "partner":"4gzd" + "partner":"1x24" }, { "sim":50.0, - "partner":"1zcl" + "partner":"4gzc" }, { "sim":50.0, @@ -653199,11 +655941,11 @@ }, { "sim":50.0, - "partner":"6uv7" + "partner":"6uvi" }, { "sim":50.0, - "partner":"6uvi" + "partner":"6uv7" }, { "sim":50.0, @@ -653253,10 +655995,6 @@ "sim":50.0, "partner":"5juh" }, - { - "sim":50.0, - "partner":"3th5" - }, { "sim":50.0, "partner":"4gzl" @@ -653267,15 +656005,15 @@ }, { "sim":50.0, - "partner":"5lau" + "partner":"3th5" }, { "sim":50.0, - "partner":"4mpz" + "partner":"5lau" }, { "sim":50.0, - "partner":"3l1u" + "partner":"4mpz" }, { "sim":50.0, @@ -653293,6 +656031,10 @@ "sim":50.0, "partner":"3esr" }, + { + "sim":50.0, + "partner":"3l1u" + }, { "sim":50.0, "partner":"2wc9" @@ -653315,11 +656057,11 @@ }, { "sim":50.0, - "partner":"7fe0" + "partner":"7fe5" }, { "sim":50.0, - "partner":"7fe5" + "partner":"7fe0" }, { "sim":50.0, @@ -653331,11 +656073,11 @@ }, { "sim":50.0, - "partner":"7w83" + "partner":"7ocj" }, { "sim":50.0, - "partner":"7ocj" + "partner":"7w83" }, { "sim":50.0, @@ -653367,15 +656109,15 @@ }, { "sim":50.0, - "partner":"6z0x" + "partner":"6z0y" }, { "sim":50.0, - "partner":"6z0y" + "partner":"6z0e" }, { "sim":50.0, - "partner":"6z0e" + "partner":"6z0x" }, { "sim":50.0, @@ -653419,31 +656161,31 @@ }, { "sim":50.0, - "partner":"6o98" + "partner":"7jh2" }, { "sim":50.0, - "partner":"7d9v" + "partner":"7d8h" }, { "sim":50.0, - "partner":"7d8p" + "partner":"6bn6" }, { "sim":50.0, - "partner":"7jh2" + "partner":"6xfv" }, { "sim":50.0, - "partner":"7d8h" + "partner":"7d9v" }, { "sim":50.0, - "partner":"6bn6" + "partner":"6o98" }, { "sim":50.0, - "partner":"6xfv" + "partner":"7d8p" }, { "sim":50.0, @@ -653539,11 +656281,11 @@ }, { "sim":50.0, - "partner":"2wk1" + "partner":"6akv" }, { "sim":50.0, - "partner":"6akv" + "partner":"2wk1" }, { "sim":50.0, @@ -653553,14 +656295,6 @@ "sim":50.0, "partner":"7dbs" }, - { - "sim":50.0, - "partner":"7kqj" - }, - { - "sim":50.0, - "partner":"6vqf" - }, { "sim":50.0, "partner":"7kxd" @@ -653599,24 +656333,32 @@ }, { "sim":50.0, - "partner":"1cbf" + "partner":"6u25" }, { "sim":50.0, - "partner":"6u25" + "partner":"7luk" }, { "sim":50.0, - "partner":"7luk" + "partner":"1cbf" }, { "sim":50.0, - "partner":"4rni" + "partner":"6vqf" + }, + { + "sim":50.0, + "partner":"7kqj" }, { "sim":50.0, "partner":"4rnj" }, + { + "sim":50.0, + "partner":"4rni" + }, { "sim":50.0, "partner":"5ldb" @@ -653657,10 +656399,6 @@ "sim":50.0, "partner":"6zzt" }, - { - "sim":50.0, - "partner":"4bwa" - }, { "sim":50.0, "partner":"2zim" @@ -653741,6 +656479,10 @@ "sim":50.0, "partner":"4bw9" }, + { + "sim":50.0, + "partner":"4bwa" + }, { "sim":50.0, "partner":"6y61" @@ -653773,10 +656515,6 @@ "sim":50.0, "partner":"5ita" }, - { - "sim":50.0, - "partner":"4rtl" - }, { "sim":50.0, "partner":"4rtm" @@ -653819,19 +656557,19 @@ }, { "sim":50.0, - "partner":"5teu" + "partner":"4rtl" }, { "sim":50.0, - "partner":"3nha" + "partner":"5teu" }, { "sim":50.0, - "partner":"3nhb" + "partner":"8tez" }, { "sim":50.0, - "partner":"8tez" + "partner":"3nh6" }, { "sim":50.0, @@ -653843,11 +656581,15 @@ }, { "sim":50.0, - "partner":"3nh6" + "partner":"3nh9" }, { "sim":50.0, - "partner":"3nh9" + "partner":"3nha" + }, + { + "sim":50.0, + "partner":"3nhb" }, { "sim":50.0, @@ -653871,24 +656613,20 @@ }, { "sim":50.0, - "partner":"1g8o" + "partner":"3zgd" }, { "sim":50.0, - "partner":"1fg5" + "partner":"1g8o" }, { "sim":50.0, - "partner":"3zgd" + "partner":"1fg5" }, { "sim":50.0, "partner":"1g93" }, - { - "sim":50.0, - "partner":"3g3d" - }, { "sim":50.0, "partner":"3bvj" @@ -653915,12 +656653,16 @@ }, { "sim":50.0, - "partner":"3el6" + "partner":"3g3d" }, { "sim":50.0, "partner":"6nr1" }, + { + "sim":50.0, + "partner":"3el6" + }, { "sim":50.0, "partner":"7e4m" @@ -653967,11 +656709,11 @@ }, { "sim":50.0, - "partner":"6lcn" + "partner":"7x1l" }, { "sim":50.0, - "partner":"7x1l" + "partner":"6lcn" }, { "sim":50.0, @@ -653991,11 +656733,11 @@ }, { "sim":50.0, - "partner":"7cje" + "partner":"7cjg" }, { "sim":50.0, - "partner":"7cjg" + "partner":"7cje" }, { "sim":50.0, @@ -654017,18 +656759,6 @@ "sim":50.0, "partner":"7r2e" }, - { - "sim":50.0, - "partner":"3uzz" - }, - { - "sim":50.0, - "partner":"4h2w" - }, - { - "sim":50.0, - "partner":"3mey" - }, { "sim":50.0, "partner":"3g1r" @@ -654067,15 +656797,15 @@ }, { "sim":50.0, - "partner":"3uzw" + "partner":"6l6w" }, { "sim":50.0, - "partner":"6l6w" + "partner":"6l6x" }, { "sim":50.0, - "partner":"6l6x" + "partner":"3uzw" }, { "sim":50.0, @@ -654091,20 +656821,28 @@ }, { "sim":50.0, - "partner":"4l3f" + "partner":"3uzz" }, { "sim":50.0, - "partner":"7cm8" + "partner":"4h2w" }, { "sim":50.0, - "partner":"7djq" + "partner":"3mey" + }, + { + "sim":50.0, + "partner":"4l3f" }, { "sim":50.0, "partner":"7c35" }, + { + "sim":50.0, + "partner":"7ewo" + }, { "sim":50.0, "partner":"6aif" @@ -654119,7 +656857,7 @@ }, { "sim":50.0, - "partner":"7ewo" + "partner":"7cm8" }, { "sim":50.0, @@ -654127,7 +656865,7 @@ }, { "sim":50.0, - "partner":"2ikf" + "partner":"7djq" }, { "sim":50.0, @@ -654159,11 +656897,7 @@ }, { "sim":50.0, - "partner":"1x19" - }, - { - "sim":50.0, - "partner":"1x1a" + "partner":"2ikf" }, { "sim":50.0, @@ -654179,12 +656913,20 @@ }, { "sim":50.0, - "partner":"3tn3" + "partner":"1x19" + }, + { + "sim":50.0, + "partner":"1x1a" }, { "sim":50.0, "partner":"7m4s" }, + { + "sim":50.0, + "partner":"3tn3" + }, { "sim":50.0, "partner":"3tn4" @@ -654213,10 +656955,6 @@ "sim":50.0, "partner":"6clx" }, - { - "sim":50.0, - "partner":"4m1i" - }, { "sim":50.0, "partner":"4d8f" @@ -654229,6 +656967,10 @@ "sim":50.0, "partner":"4m1h" }, + { + "sim":50.0, + "partner":"4m1i" + }, { "sim":50.0, "partner":"4o6e" @@ -654243,15 +656985,15 @@ }, { "sim":50.0, - "partner":"2iua" + "partner":"2iu8" }, { "sim":50.0, - "partner":"2iu8" + "partner":"2iu9" }, { "sim":50.0, - "partner":"2iu9" + "partner":"2iua" }, { "sim":50.0, @@ -654273,10 +657015,6 @@ "sim":50.0, "partner":"5zyb" }, - { - "sim":50.0, - "partner":"6put" - }, { "sim":50.0, "partner":"6puw" @@ -654289,21 +657027,17 @@ "sim":50.0, "partner":"6v3k" }, - { - "sim":50.0, - "partner":"5u1c" - }, { "sim":50.0, "partner":"6puz" }, { "sim":50.0, - "partner":"4q3r" + "partner":"5u1c" }, { "sim":50.0, - "partner":"4q42" + "partner":"6put" }, { "sim":50.0, @@ -654339,19 +657073,23 @@ }, { "sim":50.0, - "partner":"5j8x" + "partner":"4q3r" }, { "sim":50.0, - "partner":"6voy" + "partner":"4q42" }, { "sim":50.0, - "partner":"5vrd" + "partner":"5j8x" }, { "sim":50.0, - "partner":"7dib" + "partner":"6voy" + }, + { + "sim":50.0, + "partner":"5vrd" }, { "sim":50.0, @@ -654363,12 +657101,16 @@ }, { "sim":50.0, - "partner":"7sc6" + "partner":"7dib" }, { "sim":50.0, "partner":"7scq" }, + { + "sim":50.0, + "partner":"7sc6" + }, { "sim":50.0, "partner":"3au7" @@ -654415,11 +657157,11 @@ }, { "sim":50.0, - "partner":"5xw2" + "partner":"4e2p" }, { "sim":50.0, - "partner":"4e2p" + "partner":"5xw2" }, { "sim":50.0, @@ -654437,14 +657179,6 @@ "sim":50.0, "partner":"2wio" }, - { - "sim":50.0, - "partner":"6j87" - }, - { - "sim":50.0, - "partner":"6j88" - }, { "sim":50.0, "partner":"5y0n" @@ -654459,15 +657193,15 @@ }, { "sim":50.0, - "partner":"7ui4" + "partner":"6j87" }, { "sim":50.0, - "partner":"2yhg" + "partner":"6j88" }, { "sim":50.0, - "partner":"4q6q" + "partner":"7ui4" }, { "sim":50.0, @@ -654487,56 +657221,48 @@ }, { "sim":50.0, - "partner":"3amu" - }, - { - "sim":50.0, - "partner":"3amt" + "partner":"2yhg" }, { "sim":50.0, - "partner":"3tkt" + "partner":"4q6q" }, { "sim":50.0, - "partner":"7jtj" + "partner":"3amt" }, { "sim":50.0, - "partner":"7jua" + "partner":"3amu" }, { "sim":50.0, - "partner":"4rnf" + "partner":"3tkt" }, { "sim":50.0, - "partner":"4rnh" + "partner":"7jtj" }, { "sim":50.0, - "partner":"4wya" + "partner":"7jua" }, { "sim":50.0, - "partner":"4wyf" + "partner":"4rnf" }, { "sim":50.0, - "partner":"4cxq" + "partner":"4rnh" }, { "sim":50.0, - "partner":"5kgs" + "partner":"4cxr" }, { "sim":50.0, "partner":"4wyg" }, - { - "sim":50.0, - "partner":"4cxr" - }, { "sim":50.0, "partner":"4xjl" @@ -654601,13 +657327,25 @@ "sim":50.0, "partner":"3tfu" }, + { + "sim":50.0, + "partner":"4wya" + }, { "sim":50.0, "partner":"4wye" }, { "sim":50.0, - "partner":"6f47" + "partner":"4wyf" + }, + { + "sim":50.0, + "partner":"4cxq" + }, + { + "sim":50.0, + "partner":"5kgs" }, { "sim":50.0, @@ -654623,11 +657361,11 @@ }, { "sim":50.0, - "partner":"2zfn" + "partner":"6f47" }, { "sim":50.0, - "partner":"7tfc" + "partner":"2zfn" }, { "sim":50.0, @@ -654637,6 +657375,10 @@ "sim":50.0, "partner":"7tf9" }, + { + "sim":50.0, + "partner":"7tfc" + }, { "sim":50.0, "partner":"3cmj" @@ -654653,14 +657395,6 @@ "sim":50.0, "partner":"3s6k" }, - { - "sim":50.0, - "partner":"6mlh" - }, - { - "sim":50.0, - "partner":"6mlw" - }, { "sim":50.0, "partner":"6nn1" @@ -654697,6 +657431,14 @@ "sim":50.0, "partner":"6mlf" }, + { + "sim":50.0, + "partner":"6mlh" + }, + { + "sim":50.0, + "partner":"6mlw" + }, { "sim":50.0, "partner":"6j0u" @@ -654713,10 +657455,6 @@ "sim":50.0, "partner":"3taz" }, - { - "sim":50.0, - "partner":"6vy9" - }, { "sim":50.0, "partner":"6vya" @@ -654729,6 +657467,10 @@ "sim":50.0, "partner":"5xix" }, + { + "sim":50.0, + "partner":"6vy9" + }, { "sim":50.0, "partner":"4kc7" @@ -654747,11 +657489,11 @@ }, { "sim":50.0, - "partner":"7f79" + "partner":"7f77" }, { "sim":50.0, - "partner":"7f77" + "partner":"7f79" }, { "sim":50.0, @@ -654799,11 +657541,11 @@ }, { "sim":50.0, - "partner":"3mjv" + "partner":"6ta8" }, { "sim":50.0, - "partner":"6ta8" + "partner":"3mjv" }, { "sim":50.0, @@ -654921,10 +657663,6 @@ "sim":50.0, "partner":"4orc" }, - { - "sim":50.0, - "partner":"2r0p" - }, { "sim":50.0, "partner":"2r0c" @@ -654937,6 +657675,10 @@ "sim":50.0, "partner":"3ept" }, + { + "sim":50.0, + "partner":"2r0p" + }, { "sim":50.0, "partner":"6jfb" @@ -654991,11 +657733,11 @@ }, { "sim":50.0, - "partner":"2vbg" + "partner":"2vbf" }, { "sim":50.0, - "partner":"2vbf" + "partner":"2vbg" }, { "sim":50.0, @@ -655011,11 +657753,11 @@ }, { "sim":50.0, - "partner":"5ess" + "partner":"5esd" }, { "sim":50.0, - "partner":"5esd" + "partner":"5ess" }, { "sim":50.0, @@ -655059,15 +657801,15 @@ }, { "sim":50.0, - "partner":"5tsh" + "partner":"6olj" }, { "sim":50.0, - "partner":"6olj" + "partner":"5tsg" }, { "sim":50.0, - "partner":"5tsg" + "partner":"5tsh" }, { "sim":50.0, @@ -655153,10 +657895,6 @@ "sim":50.0, "partner":"8exd" }, - { - "sim":50.0, - "partner":"5t4a" - }, { "sim":50.0, "partner":"5t4c" @@ -655167,7 +657905,7 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"5t4a" }, { "sim":50.0, @@ -655177,6 +657915,10 @@ "sim":50.0, "partner":"6ee1" }, + { + "sim":50.0, + "partner":"6edw" + }, { "sim":50.0, "partner":"3slk" @@ -655308,10 +658050,10 @@ ], "subtitle":"Ancestral petase 35_442 mutant f93l", "tags":[ - "petase", "pet", - "hydrolase", "plastic degradation", + "petase", + "hydrolase", "ancestral sequence reconstruction" ], "keywords":[ @@ -655381,11 +658123,11 @@ }, { "sim":51.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":51.0, - "partner":"8w08" + "partner":"8v0a" }, { "sim":50.0, @@ -655401,11 +658143,11 @@ }, { "sim":50.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":50.0, - "partner":"8w05" + "partner":"8w06" } ], "seq_thr_sim_natural":[ @@ -655447,11 +658189,11 @@ }, { "sim":415.0, - "partner":"7xtu" + "partner":"7xtv" }, { "sim":415.0, - "partner":"7xtv" + "partner":"7xtu" }, { "sim":415.0, @@ -655491,20 +658233,16 @@ }, { "sim":398.0, - "partner":"7e31" + "partner":"7w69" }, { "sim":398.0, - "partner":"7w69" + "partner":"7e31" }, { "sim":398.0, "partner":"7w66" }, - { - "sim":396.0, - "partner":"7e30" - }, { "sim":396.0, "partner":"7cuv" @@ -655517,6 +658255,10 @@ "sim":396.0, "partner":"7w6o" }, + { + "sim":396.0, + "partner":"7e30" + }, { "sim":396.0, "partner":"7w6q" @@ -655571,15 +658313,15 @@ }, { "sim":380.0, - "partner":"7cts" + "partner":"8ibl" }, { "sim":380.0, - "partner":"8ibl" + "partner":"8ibm" }, { "sim":380.0, - "partner":"8ibm" + "partner":"7cts" }, { "sim":380.0, @@ -655639,15 +658381,15 @@ }, { "sim":323.0, - "partner":"7vvc" + "partner":"7w45" }, { "sim":323.0, - "partner":"7w45" + "partner":"7w1n" }, { "sim":323.0, - "partner":"7w1n" + "partner":"7vvc" }, { "sim":321.0, @@ -655687,15 +658429,15 @@ }, { "sim":305.0, - "partner":"6kuq" + "partner":"5xjh" }, { "sim":305.0, - "partner":"5xjh" + "partner":"6kuo" }, { "sim":305.0, - "partner":"6kuo" + "partner":"6kuq" }, { "sim":304.0, @@ -655807,23 +658549,23 @@ }, { "sim":273.0, - "partner":"6eqd" + "partner":"6eqg" }, { "sim":273.0, - "partner":"6eqe" + "partner":"6eqh" }, { "sim":273.0, - "partner":"6eqf" + "partner":"6eqd" }, { "sim":273.0, - "partner":"6eqg" + "partner":"6eqe" }, { "sim":273.0, - "partner":"6eqh" + "partner":"6eqf" }, { "sim":272.0, @@ -655905,6 +658647,26 @@ "sim":250.0, "partner":"8spk" }, + { + "sim":241.0, + "partner":"8ytu" + }, + { + "sim":239.0, + "partner":"8ytv" + }, + { + "sim":221.0, + "partner":"8yty" + }, + { + "sim":219.0, + "partner":"8ytw" + }, + { + "sim":215.0, + "partner":"8ytz" + }, { "sim":140.0, "partner":"7pzj" @@ -655917,10 +658679,6 @@ "sim":73.0, "partner":"2fx5" }, - { - "sim":63.0, - "partner":"4ke6" - }, { "sim":63.0, "partner":"4ke7" @@ -655941,6 +658699,10 @@ "sim":63.0, "partner":"3rli" }, + { + "sim":63.0, + "partner":"4ke6" + }, { "sim":60.0, "partner":"4ke9" @@ -655959,51 +658721,51 @@ }, { "sim":58.0, - "partner":"7q2b" + "partner":"7q2f" }, { "sim":58.0, - "partner":"3ha3" + "partner":"7q2g" }, { "sim":58.0, - "partner":"7q2c" + "partner":"7q2h" }, { "sim":58.0, - "partner":"7q2d" + "partner":"3ha5" }, { "sim":58.0, - "partner":"7q2e" + "partner":"2fk7" }, { "sim":58.0, - "partner":"7q2f" + "partner":"2fk8" }, { "sim":58.0, - "partner":"7q2g" + "partner":"3ha7" }, { "sim":58.0, - "partner":"7q2h" + "partner":"7q2b" }, { "sim":58.0, - "partner":"3ha5" + "partner":"7q2c" }, { "sim":58.0, - "partner":"2fk7" + "partner":"3ha3" }, { "sim":58.0, - "partner":"2fk8" + "partner":"7q2d" }, { "sim":58.0, - "partner":"3ha7" + "partner":"7q2e" }, { "sim":58.0, @@ -656045,10 +658807,6 @@ "sim":57.0, "partner":"6ve6" }, - { - "sim":57.0, - "partner":"4lre" - }, { "sim":57.0, "partner":"4lrf" @@ -656081,6 +658839,10 @@ "sim":57.0, "partner":"4lrd" }, + { + "sim":57.0, + "partner":"4lre" + }, { "sim":57.0, "partner":"7ozc" @@ -656115,15 +658877,15 @@ }, { "sim":56.0, - "partner":"7w1c" + "partner":"7w1d" }, { "sim":56.0, - "partner":"7w1d" + "partner":"7w1e" }, { "sim":56.0, - "partner":"7w1e" + "partner":"7w1c" }, { "sim":55.0, @@ -656155,11 +658917,11 @@ }, { "sim":55.0, - "partner":"3kwe" + "partner":"3kwd" }, { "sim":55.0, - "partner":"3kwd" + "partner":"3kwe" }, { "sim":55.0, @@ -656175,23 +658937,23 @@ }, { "sim":55.0, - "partner":"6ub4" + "partner":"6ub2" }, { "sim":55.0, - "partner":"6ub5" + "partner":"6ub3" }, { "sim":55.0, - "partner":"6ub6" + "partner":"6ub4" }, { "sim":55.0, - "partner":"6ub2" + "partner":"6ub5" }, { "sim":55.0, - "partner":"6ub3" + "partner":"6ub6" }, { "sim":55.0, @@ -656247,15 +659009,15 @@ }, { "sim":55.0, - "partner":"5dvi" + "partner":"5dvj" }, { "sim":55.0, - "partner":"5dvj" + "partner":"5dvf" }, { "sim":55.0, - "partner":"5dvf" + "partner":"5dvi" }, { "sim":55.0, @@ -656269,10 +659031,6 @@ "sim":55.0, "partner":"4y0k" }, - { - "sim":55.0, - "partner":"4tm4" - }, { "sim":55.0, "partner":"4tlx" @@ -656293,6 +659051,10 @@ "sim":55.0, "partner":"4tm3" }, + { + "sim":55.0, + "partner":"4tm4" + }, { "sim":55.0, "partner":"6rim" @@ -656353,14 +659115,6 @@ "sim":54.0, "partner":"4n57" }, - { - "sim":54.0, - "partner":"2nq6" - }, - { - "sim":54.0, - "partner":"2nq7" - }, { "sim":54.0, "partner":"2b3k" @@ -656403,7 +659157,11 @@ }, { "sim":54.0, - "partner":"2o0h" + "partner":"2nq6" + }, + { + "sim":54.0, + "partner":"2nq7" }, { "sim":54.0, @@ -656415,19 +659173,19 @@ }, { "sim":54.0, - "partner":"5ngw" + "partner":"2o0h" }, { "sim":54.0, - "partner":"2o1b" + "partner":"5ngw" }, { "sim":54.0, - "partner":"4bko" + "partner":"2o1b" }, { "sim":54.0, - "partner":"5cu7" + "partner":"4bko" }, { "sim":54.0, @@ -656441,6 +659199,10 @@ "sim":54.0, "partner":"5cx4" }, + { + "sim":54.0, + "partner":"5cu7" + }, { "sim":54.0, "partner":"3zlf" @@ -656533,10 +659295,6 @@ "sim":53.0, "partner":"2k4z" }, - { - "sim":53.0, - "partner":"6ebc" - }, { "sim":53.0, "partner":"6ebd" @@ -656549,6 +659307,10 @@ "sim":53.0, "partner":"6eb4" }, + { + "sim":53.0, + "partner":"6ebc" + }, { "sim":53.0, "partner":"6ecy" @@ -656595,15 +659357,11 @@ }, { "sim":53.0, - "partner":"6pj9" - }, - { - "sim":53.0, - "partner":"6pja" + "partner":"6pjp" }, { "sim":53.0, - "partner":"6pjp" + "partner":"6pjq" }, { "sim":53.0, @@ -656611,11 +659369,11 @@ }, { "sim":53.0, - "partner":"6pjq" + "partner":"6pjr" }, { "sim":53.0, - "partner":"6pjr" + "partner":"6pju" }, { "sim":53.0, @@ -656625,10 +659383,6 @@ "sim":53.0, "partner":"5f5d" }, - { - "sim":53.0, - "partner":"6pju" - }, { "sim":53.0, "partner":"4njp" @@ -656651,15 +659405,19 @@ }, { "sim":53.0, - "partner":"5f5j" + "partner":"6pj5" }, { "sim":53.0, - "partner":"6pj5" + "partner":"6pj7" }, { "sim":53.0, - "partner":"6pj7" + "partner":"5f5j" + }, + { + "sim":53.0, + "partner":"6pj8" }, { "sim":53.0, @@ -656667,7 +659425,11 @@ }, { "sim":53.0, - "partner":"6pj8" + "partner":"6pj9" + }, + { + "sim":53.0, + "partner":"6pja" }, { "sim":53.0, @@ -656687,11 +659449,11 @@ }, { "sim":53.0, - "partner":"6ey1" + "partner":"6f0w" }, { "sim":53.0, - "partner":"6f0w" + "partner":"6ey1" }, { "sim":53.0, @@ -656725,10 +659487,6 @@ "sim":53.0, "partner":"6itx" }, - { - "sim":53.0, - "partner":"4pgc" - }, { "sim":53.0, "partner":"4pgd" @@ -656747,7 +659505,7 @@ }, { "sim":53.0, - "partner":"3s3h" + "partner":"4pgc" }, { "sim":53.0, @@ -656761,6 +659519,10 @@ "sim":53.0, "partner":"3s3f" }, + { + "sim":53.0, + "partner":"3s3h" + }, { "sim":53.0, "partner":"6xtu" @@ -656795,28 +659557,24 @@ }, { "sim":53.0, - "partner":"7q4u" + "partner":"7zf2" }, { "sim":53.0, - "partner":"7q59" + "partner":"7q4u" }, { "sim":53.0, - "partner":"7pp4" + "partner":"7q59" }, { "sim":53.0, - "partner":"7zf2" + "partner":"7pp4" }, { "sim":53.0, "partner":"4xq6" }, - { - "sim":53.0, - "partner":"7ajm" - }, { "sim":53.0, "partner":"7a4r" @@ -656831,23 +659589,7 @@ }, { "sim":53.0, - "partner":"7a53" - }, - { - "sim":53.0, - "partner":"7ajw" - }, - { - "sim":53.0, - "partner":"7akb" - }, - { - "sim":53.0, - "partner":"7ajy" - }, - { - "sim":53.0, - "partner":"7a5l" + "partner":"7ajm" }, { "sim":53.0, @@ -656909,10 +659651,30 @@ "sim":53.0, "partner":"7aka" }, + { + "sim":53.0, + "partner":"7a53" + }, { "sim":53.0, "partner":"7akl" }, + { + "sim":53.0, + "partner":"7ajw" + }, + { + "sim":53.0, + "partner":"7akb" + }, + { + "sim":53.0, + "partner":"7ajy" + }, + { + "sim":53.0, + "partner":"7a5l" + }, { "sim":53.0, "partner":"3wcg" @@ -656991,15 +659753,15 @@ }, { "sim":53.0, - "partner":"7cl7" + "partner":"6l69" }, { "sim":53.0, - "partner":"7cl8" + "partner":"7cl7" }, { "sim":53.0, - "partner":"6l69" + "partner":"7cl8" }, { "sim":53.0, @@ -657007,27 +659769,27 @@ }, { "sim":53.0, - "partner":"6ry0" + "partner":"6ry5" }, { "sim":53.0, - "partner":"6ry1" + "partner":"6ry6" }, { "sim":53.0, - "partner":"6ry2" + "partner":"6ry7" }, { "sim":53.0, - "partner":"6ry5" + "partner":"6ry0" }, { "sim":53.0, - "partner":"6ry6" + "partner":"6ry1" }, { "sim":53.0, - "partner":"6ry7" + "partner":"6ry2" }, { "sim":53.0, @@ -657197,10 +659959,6 @@ "sim":53.0, "partner":"5x7h" }, - { - "sim":53.0, - "partner":"5y1h" - }, { "sim":53.0, "partner":"5y1k" @@ -657247,15 +660005,19 @@ }, { "sim":53.0, - "partner":"6tsh" + "partner":"5y1h" }, { "sim":53.0, - "partner":"6tte" + "partner":"6tsk" }, { "sim":53.0, - "partner":"6tsk" + "partner":"6tsh" + }, + { + "sim":53.0, + "partner":"6tte" }, { "sim":52.0, @@ -657323,11 +660085,11 @@ }, { "sim":52.0, - "partner":"1wc6" + "partner":"1wc1" }, { "sim":52.0, - "partner":"1wc1" + "partner":"1wc6" }, { "sim":52.0, @@ -657335,16 +660097,12 @@ }, { "sim":52.0, - "partner":"7o2t" + "partner":"6z17" }, { "sim":52.0, "partner":"7o2u" }, - { - "sim":52.0, - "partner":"6z17" - }, { "sim":52.0, "partner":"6yz3" @@ -657361,6 +660119,10 @@ "sim":52.0, "partner":"6z5k" }, + { + "sim":52.0, + "partner":"7o2t" + }, { "sim":52.0, "partner":"1zw9" @@ -657381,10 +660143,6 @@ "sim":52.0, "partner":"3c0e" }, - { - "sim":52.0, - "partner":"3la7" - }, { "sim":52.0, "partner":"3la2" @@ -657397,6 +660155,10 @@ "sim":52.0, "partner":"3qc1" }, + { + "sim":52.0, + "partner":"3la7" + }, { "sim":52.0, "partner":"6kdr" @@ -657441,14 +660203,6 @@ "sim":52.0, "partner":"2ntn" }, - { - "sim":52.0, - "partner":"5ds3" - }, - { - "sim":52.0, - "partner":"6bhv" - }, { "sim":52.0, "partner":"6ntu" @@ -657477,6 +660231,14 @@ "sim":52.0, "partner":"6nrj" }, + { + "sim":52.0, + "partner":"6bhv" + }, + { + "sim":52.0, + "partner":"5ds3" + }, { "sim":52.0, "partner":"6dli" @@ -657487,23 +660249,23 @@ }, { "sim":52.0, - "partner":"6hxo" + "partner":"6hxn" }, { "sim":52.0, - "partner":"6hxn" + "partner":"6hxo" }, { "sim":52.0, - "partner":"6t2p" + "partner":"6t2o" }, { "sim":52.0, - "partner":"6t2q" + "partner":"6t2p" }, { "sim":52.0, - "partner":"6t2o" + "partner":"6t2q" }, { "sim":52.0, @@ -657521,10 +660283,6 @@ "sim":52.0, "partner":"6y66" }, - { - "sim":52.0, - "partner":"3aio" - }, { "sim":52.0, "partner":"3aik" @@ -657543,11 +660301,11 @@ }, { "sim":52.0, - "partner":"3utn" + "partner":"3aio" }, { "sim":52.0, - "partner":"7btm" + "partner":"3utn" }, { "sim":52.0, @@ -657555,7 +660313,7 @@ }, { "sim":52.0, - "partner":"2pt0" + "partner":"7btm" }, { "sim":52.0, @@ -657577,61 +660335,65 @@ "sim":52.0, "partner":"2psz" }, + { + "sim":52.0, + "partner":"2pt0" + }, { "sim":52.0, "partner":"3pdc" }, { "sim":52.0, - "partner":"4g2f" + "partner":"3dzq" }, { "sim":52.0, - "partner":"4gk3" + "partner":"4p5z" }, { "sim":52.0, - "partner":"4gk4" + "partner":"4twn" }, { "sim":52.0, - "partner":"4p5q" + "partner":"4two" }, { "sim":52.0, - "partner":"3dzq" + "partner":"4p4c" }, { "sim":52.0, - "partner":"4p5z" + "partner":"4gk2" }, { "sim":52.0, - "partner":"4twn" + "partner":"4g2f" }, { "sim":52.0, - "partner":"4two" + "partner":"4gk3" }, { "sim":52.0, - "partner":"4p4c" + "partner":"4gk4" }, { "sim":52.0, - "partner":"4gk2" + "partner":"4p5q" }, { "sim":52.0, - "partner":"5eeg" + "partner":"5eeh" }, { "sim":52.0, - "partner":"5jr3" + "partner":"5eeg" }, { "sim":52.0, - "partner":"5eeh" + "partner":"5jr3" }, { "sim":52.0, @@ -657711,11 +660473,11 @@ }, { "sim":52.0, - "partner":"7r39" + "partner":"3c48" }, { "sim":52.0, - "partner":"3c48" + "partner":"7r39" }, { "sim":52.0, @@ -657725,21 +660487,17 @@ "sim":52.0, "partner":"5h9y" }, - { - "sim":52.0, - "partner":"8il0" - }, { "sim":52.0, "partner":"8ila" }, { "sim":52.0, - "partner":"4zm3" + "partner":"8il0" }, { "sim":52.0, - "partner":"4acg" + "partner":"4zm3" }, { "sim":52.0, @@ -657755,15 +660513,15 @@ }, { "sim":52.0, - "partner":"2fwr" + "partner":"4acg" }, { "sim":52.0, - "partner":"5bwf" + "partner":"2fwr" }, { "sim":52.0, - "partner":"6rk2" + "partner":"5bwf" }, { "sim":52.0, @@ -657777,6 +660535,10 @@ "sim":52.0, "partner":"6rjm" }, + { + "sim":52.0, + "partner":"6rk2" + }, { "sim":52.0, "partner":"6yyh" @@ -657801,26 +660563,18 @@ "sim":52.0, "partner":"6ms3" }, - { - "sim":52.0, - "partner":"4bzc" - }, { "sim":52.0, "partner":"4qg1" }, { "sim":52.0, - "partner":"6dwk" + "partner":"6dwd" }, { "sim":52.0, "partner":"4qg2" }, - { - "sim":52.0, - "partner":"6dwd" - }, { "sim":52.0, "partner":"7s2y" @@ -657869,6 +660623,14 @@ "sim":52.0, "partner":"4qg0" }, + { + "sim":52.0, + "partner":"6dwk" + }, + { + "sim":52.0, + "partner":"4bzc" + }, { "sim":52.0, "partner":"3u9s" @@ -657893,10 +660655,6 @@ "sim":52.0, "partner":"5wdg" }, - { - "sim":52.0, - "partner":"2fw3" - }, { "sim":52.0, "partner":"4ep9" @@ -657919,15 +660677,11 @@ }, { "sim":52.0, - "partner":"8va7" - }, - { - "sim":52.0, - "partner":"4j3t" + "partner":"2fw3" }, { "sim":52.0, - "partner":"4j3u" + "partner":"8va7" }, { "sim":52.0, @@ -657945,6 +660699,14 @@ "sim":52.0, "partner":"4j3s" }, + { + "sim":52.0, + "partner":"4j3t" + }, + { + "sim":52.0, + "partner":"4j3u" + }, { "sim":52.0, "partner":"6i60" @@ -658117,10 +660879,6 @@ "sim":51.0, "partner":"6o20" }, - { - "sim":51.0, - "partner":"5c7p" - }, { "sim":51.0, "partner":"7f0y" @@ -658141,6 +660899,10 @@ "sim":51.0, "partner":"7f11" }, + { + "sim":51.0, + "partner":"5c7p" + }, { "sim":51.0, "partner":"4ip3" @@ -658151,11 +660913,11 @@ }, { "sim":51.0, - "partner":"5k24" + "partner":"5k22" }, { "sim":51.0, - "partner":"5k22" + "partner":"5k24" }, { "sim":51.0, @@ -658233,10 +660995,6 @@ "sim":51.0, "partner":"7r1n" }, - { - "sim":51.0, - "partner":"5l9k" - }, { "sim":51.0, "partner":"5l9q" @@ -658249,6 +661007,10 @@ "sim":51.0, "partner":"5lbp" }, + { + "sim":51.0, + "partner":"5l9k" + }, { "sim":51.0, "partner":"6erd" @@ -658275,19 +661037,19 @@ }, { "sim":51.0, - "partner":"8b9b" + "partner":"8b9a" }, { "sim":51.0, - "partner":"6skl" + "partner":"8b9c" }, { "sim":51.0, - "partner":"8b9a" + "partner":"8b9b" }, { "sim":51.0, - "partner":"8b9c" + "partner":"6skl" }, { "sim":51.0, @@ -658335,11 +661097,11 @@ }, { "sim":51.0, - "partner":"3tjo" + "partner":"7bez" }, { "sim":51.0, - "partner":"7bez" + "partner":"3tjo" }, { "sim":51.0, @@ -658363,31 +661125,31 @@ }, { "sim":51.0, - "partner":"7mnq" + "partner":"7mns" }, { "sim":51.0, - "partner":"7mnr" + "partner":"7mnt" }, { "sim":51.0, - "partner":"7mns" + "partner":"7mnu" }, { "sim":51.0, - "partner":"7mnt" + "partner":"7mnv" }, { "sim":51.0, - "partner":"7mnu" + "partner":"6z0e" }, { "sim":51.0, - "partner":"7mnv" + "partner":"7mnq" }, { "sim":51.0, - "partner":"6z0e" + "partner":"7mnr" }, { "sim":51.0, @@ -658489,26 +661251,18 @@ "sim":51.0, "partner":"4jlj" }, - { - "sim":51.0, - "partner":"7zi1" - }, { "sim":51.0, "partner":"4kcg" }, { "sim":51.0, - "partner":"7zi2" + "partner":"7zi3" }, { "sim":51.0, "partner":"4jlk" }, - { - "sim":51.0, - "partner":"7zi3" - }, { "sim":51.0, "partner":"2no6" @@ -658573,13 +661327,17 @@ "sim":51.0, "partner":"2qro" }, + { + "sim":51.0, + "partner":"7zi5" + }, { "sim":51.0, "partner":"4q1f" }, { "sim":51.0, - "partner":"7zi5" + "partner":"7zi6" }, { "sim":51.0, @@ -658587,11 +661345,11 @@ }, { "sim":51.0, - "partner":"7zi6" + "partner":"7zi7" }, { "sim":51.0, - "partner":"7zi7" + "partner":"7zi8" }, { "sim":51.0, @@ -658599,7 +661357,7 @@ }, { "sim":51.0, - "partner":"7zi8" + "partner":"7zi9" }, { "sim":51.0, @@ -658607,15 +661365,19 @@ }, { "sim":51.0, - "partner":"7zi9" + "partner":"7zia" }, { "sim":51.0, - "partner":"7zia" + "partner":"7zib" }, { "sim":51.0, - "partner":"7zib" + "partner":"7zi1" + }, + { + "sim":51.0, + "partner":"7zi2" }, { "sim":51.0, @@ -658635,19 +661397,19 @@ }, { "sim":51.0, - "partner":"7a61" + "partner":"8rwq" }, { "sim":51.0, - "partner":"5uj3" + "partner":"6mnp" }, { "sim":51.0, - "partner":"5uj4" + "partner":"8rwr" }, { "sim":51.0, - "partner":"6mnp" + "partner":"5uj3" }, { "sim":51.0, @@ -658655,7 +661417,11 @@ }, { "sim":51.0, - "partner":"5ul8" + "partner":"8rws" + }, + { + "sim":51.0, + "partner":"5uj4" }, { "sim":51.0, @@ -658669,6 +661435,10 @@ "sim":51.0, "partner":"6d17" }, + { + "sim":51.0, + "partner":"5ul8" + }, { "sim":51.0, "partner":"6d18" @@ -658727,15 +661497,15 @@ }, { "sim":51.0, - "partner":"8rwq" + "partner":"6mey" }, { "sim":51.0, - "partner":"6mey" + "partner":"6v1j" }, { "sim":51.0, - "partner":"6v1j" + "partner":"8aki" }, { "sim":51.0, @@ -658743,7 +661513,7 @@ }, { "sim":51.0, - "partner":"8aki" + "partner":"8akj" }, { "sim":51.0, @@ -658755,16 +661525,12 @@ }, { "sim":51.0, - "partner":"8akj" + "partner":"8akk" }, { "sim":51.0, "partner":"6td1" }, - { - "sim":51.0, - "partner":"8akk" - }, { "sim":51.0, "partner":"8akl" @@ -658785,6 +661551,18 @@ "sim":51.0, "partner":"4cp2" }, + { + "sim":51.0, + "partner":"7a61" + }, + { + "sim":51.0, + "partner":"8rwo" + }, + { + "sim":51.0, + "partner":"8rwp" + }, { "sim":51.0, "partner":"7bvx" @@ -658827,35 +661605,35 @@ }, { "sim":51.0, - "partner":"8wlb" + "partner":"8wl5" }, { "sim":51.0, - "partner":"6vlx" + "partner":"8wl7" }, { "sim":51.0, - "partner":"6vly" + "partner":"8wl9" }, { "sim":51.0, - "partner":"8wl5" + "partner":"8wlb" }, { "sim":51.0, - "partner":"8wl7" + "partner":"6vlx" }, { "sim":51.0, - "partner":"8wl9" + "partner":"6vly" }, { "sim":51.0, - "partner":"6y5x" + "partner":"6y5y" }, { "sim":51.0, - "partner":"6y5y" + "partner":"6y5x" }, { "sim":51.0, @@ -658893,14 +661671,6 @@ "sim":51.0, "partner":"6kxh" }, - { - "sim":51.0, - "partner":"5gg5" - }, - { - "sim":51.0, - "partner":"5xd1" - }, { "sim":51.0, "partner":"5gg6" @@ -658915,27 +661685,27 @@ }, { "sim":51.0, - "partner":"5gg7" + "partner":"6m6y" }, { "sim":51.0, - "partner":"5xd4" + "partner":"5gg7" }, { "sim":51.0, - "partner":"5xd5" + "partner":"5xd4" }, { "sim":51.0, - "partner":"6m6y" + "partner":"6m65" }, { "sim":51.0, - "partner":"5gg8" + "partner":"5xd5" }, { "sim":51.0, - "partner":"6m65" + "partner":"5gg8" }, { "sim":51.0, @@ -658971,19 +661741,19 @@ }, { "sim":51.0, - "partner":"8bfr" + "partner":"5gg5" }, { "sim":51.0, - "partner":"8bft" + "partner":"5xd1" }, { "sim":51.0, - "partner":"4mfj" + "partner":"8bfr" }, { "sim":51.0, - "partner":"4mfk" + "partner":"8bft" }, { "sim":51.0, @@ -658991,19 +661761,23 @@ }, { "sim":51.0, - "partner":"6iix" + "partner":"4mfp" }, { "sim":51.0, - "partner":"4mfp" + "partner":"4mfq" }, { "sim":51.0, - "partner":"4mfq" + "partner":"4mfj" }, { "sim":51.0, - "partner":"3uzz" + "partner":"6iix" + }, + { + "sim":51.0, + "partner":"4mfk" }, { "sim":51.0, @@ -659045,6 +661819,10 @@ "sim":51.0, "partner":"3uzy" }, + { + "sim":51.0, + "partner":"3uzz" + }, { "sim":51.0, "partner":"4dr0" @@ -659141,10 +661919,6 @@ "sim":51.0, "partner":"5zyb" }, - { - "sim":51.0, - "partner":"3skv" - }, { "sim":51.0, "partner":"4gmg" @@ -659159,11 +661933,11 @@ }, { "sim":51.0, - "partner":"7ct4" + "partner":"3skv" }, { "sim":51.0, - "partner":"5hxu" + "partner":"7ct4" }, { "sim":51.0, @@ -659171,23 +661945,19 @@ }, { "sim":51.0, - "partner":"5hxz" - }, - { - "sim":51.0, - "partner":"5hwe" + "partner":"8g5s" }, { "sim":51.0, - "partner":"8g5s" + "partner":"5hxz" }, { "sim":51.0, - "partner":"3dyh" + "partner":"5hwe" }, { "sim":51.0, - "partner":"4rxd" + "partner":"5hxu" }, { "sim":51.0, @@ -659231,19 +662001,19 @@ }, { "sim":51.0, - "partner":"6zgp" + "partner":"4rxd" }, { "sim":51.0, - "partner":"6y8j" + "partner":"3dyh" }, { "sim":51.0, - "partner":"6y9c" + "partner":"6y9d" }, { "sim":51.0, - "partner":"6y9d" + "partner":"6zgp" }, { "sim":51.0, @@ -659251,11 +662021,15 @@ }, { "sim":51.0, - "partner":"3bu7" + "partner":"6y8j" }, { "sim":51.0, - "partner":"5oyc" + "partner":"6y9c" + }, + { + "sim":51.0, + "partner":"3bu7" }, { "sim":51.0, @@ -659263,12 +662037,16 @@ }, { "sim":51.0, - "partner":"5oyd" + "partner":"5oyc" }, { "sim":51.0, "partner":"6haa" }, + { + "sim":51.0, + "partner":"5oyd" + }, { "sim":51.0, "partner":"5oye" @@ -659287,15 +662065,15 @@ }, { "sim":51.0, - "partner":"8bdq" + "partner":"6m7l" }, { "sim":51.0, - "partner":"6m7l" + "partner":"4zas" }, { "sim":51.0, - "partner":"4zas" + "partner":"8bdq" }, { "sim":51.0, @@ -659307,15 +662085,15 @@ }, { "sim":51.0, - "partner":"3wkr" + "partner":"3wks" }, { "sim":51.0, - "partner":"3wks" + "partner":"7xp7" }, { "sim":51.0, - "partner":"7xp7" + "partner":"3wkr" }, { "sim":51.0, @@ -659349,10 +662127,6 @@ "sim":51.0, "partner":"5y0o" }, - { - "sim":51.0, - "partner":"4b7s" - }, { "sim":51.0, "partner":"2vz7" @@ -659377,6 +662151,10 @@ "sim":51.0, "partner":"4umz" }, + { + "sim":51.0, + "partner":"4b7s" + }, { "sim":51.0, "partner":"5ysw" @@ -659395,19 +662173,27 @@ }, { "sim":51.0, - "partner":"4gt2" + "partner":"3e1h" }, { "sim":51.0, - "partner":"3e1h" + "partner":"8wn5" }, { "sim":51.0, - "partner":"3hzz" + "partner":"8wn6" }, { "sim":51.0, - "partner":"2wc4" + "partner":"8wna" + }, + { + "sim":51.0, + "partner":"4gt2" + }, + { + "sim":51.0, + "partner":"3hzz" }, { "sim":51.0, @@ -659521,21 +662307,25 @@ "sim":51.0, "partner":"1uz1" }, + { + "sim":51.0, + "partner":"2wc4" + }, { "sim":51.0, "partner":"6ksu" }, { "sim":51.0, - "partner":"5zxg" + "partner":"6ksv" }, { "sim":51.0, - "partner":"6a0j" + "partner":"5zxg" }, { "sim":51.0, - "partner":"6ksv" + "partner":"6a0j" }, { "sim":51.0, @@ -659571,11 +662361,11 @@ }, { "sim":51.0, - "partner":"6n1a" + "partner":"7anb" }, { "sim":51.0, - "partner":"7anb" + "partner":"6n1a" }, { "sim":51.0, @@ -659601,10 +662391,6 @@ "sim":51.0, "partner":"5m1e" }, - { - "sim":51.0, - "partner":"2cj9" - }, { "sim":51.0, "partner":"2cja" @@ -659617,6 +662403,10 @@ "sim":51.0, "partner":"2cjb" }, + { + "sim":51.0, + "partner":"2cj9" + }, { "sim":51.0, "partner":"4k2x" @@ -659637,14 +662427,6 @@ "sim":51.0, "partner":"6xt1" }, - { - "sim":51.0, - "partner":"8aq3" - }, - { - "sim":51.0, - "partner":"8aq4" - }, { "sim":51.0, "partner":"7aci" @@ -659653,10 +662435,6 @@ "sim":51.0, "partner":"8b0k" }, - { - "sim":51.0, - "partner":"5n6h" - }, { "sim":51.0, "partner":"8b0l" @@ -659669,6 +662447,10 @@ "sim":51.0, "partner":"8b0n" }, + { + "sim":51.0, + "partner":"5n6h" + }, { "sim":51.0, "partner":"8b0o" @@ -659683,11 +662465,15 @@ }, { "sim":51.0, - "partner":"3p0b" + "partner":"8aq3" }, { "sim":51.0, - "partner":"2r0p" + "partner":"8aq4" + }, + { + "sim":51.0, + "partner":"3p0b" }, { "sim":51.0, @@ -659701,6 +662487,10 @@ "sim":51.0, "partner":"3ept" }, + { + "sim":51.0, + "partner":"2r0p" + }, { "sim":51.0, "partner":"3hx6" @@ -659755,11 +662545,11 @@ }, { "sim":51.0, - "partner":"7jwf" + "partner":"7jw4" }, { "sim":51.0, - "partner":"7jw4" + "partner":"7jwf" }, { "sim":51.0, @@ -659793,10 +662583,6 @@ "sim":51.0, "partner":"6nff" }, - { - "sim":51.0, - "partner":"6jr8" - }, { "sim":51.0, "partner":"6jr6" @@ -659807,7 +662593,7 @@ }, { "sim":51.0, - "partner":"6yt0" + "partner":"6jr8" }, { "sim":51.0, @@ -659825,6 +662611,10 @@ "sim":51.0, "partner":"6ytj" }, + { + "sim":51.0, + "partner":"6yt0" + }, { "sim":51.0, "partner":"2zxq" @@ -659857,10 +662647,6 @@ "sim":50.0, "partner":"2f09" }, - { - "sim":50.0, - "partner":"7vp1" - }, { "sim":50.0, "partner":"7vp2" @@ -659877,6 +662663,10 @@ "sim":50.0, "partner":"7vp4" }, + { + "sim":50.0, + "partner":"7vp1" + }, { "sim":50.0, "partner":"4h2s" @@ -659937,10 +662727,6 @@ "sim":50.0, "partner":"1te4" }, - { - "sim":50.0, - "partner":"4hmr" - }, { "sim":50.0, "partner":"7u0u" @@ -659955,7 +662741,7 @@ }, { "sim":50.0, - "partner":"6bev" + "partner":"4hmr" }, { "sim":50.0, @@ -659971,15 +662757,15 @@ }, { "sim":50.0, - "partner":"2kg1" + "partner":"6bev" }, { "sim":50.0, - "partner":"2hgn" + "partner":"2kg1" }, { "sim":50.0, - "partner":"3vwb" + "partner":"2hgn" }, { "sim":50.0, @@ -659989,6 +662775,10 @@ "sim":50.0, "partner":"3w3c" }, + { + "sim":50.0, + "partner":"3vwb" + }, { "sim":50.0, "partner":"6bbx" @@ -660025,10 +662815,6 @@ "sim":50.0, "partner":"6rcx" }, - { - "sim":50.0, - "partner":"5wqi" - }, { "sim":50.0, "partner":"5wqf" @@ -660041,6 +662827,10 @@ "sim":50.0, "partner":"5wqh" }, + { + "sim":50.0, + "partner":"5wqi" + }, { "sim":50.0, "partner":"2o4e" @@ -660107,19 +662897,19 @@ }, { "sim":50.0, - "partner":"1x24" + "partner":"4gzd" }, { "sim":50.0, - "partner":"4gzc" + "partner":"1zcl" }, { "sim":50.0, - "partner":"4gzd" + "partner":"1x24" }, { "sim":50.0, - "partner":"1zcl" + "partner":"4gzc" }, { "sim":50.0, @@ -660135,11 +662925,11 @@ }, { "sim":50.0, - "partner":"6uv7" + "partner":"6uvi" }, { "sim":50.0, - "partner":"6uvi" + "partner":"6uv7" }, { "sim":50.0, @@ -660179,19 +662969,19 @@ }, { "sim":50.0, - "partner":"3th5" + "partner":"4gzl" }, { "sim":50.0, - "partner":"4c76" + "partner":"4gzm" }, { "sim":50.0, - "partner":"4gzl" + "partner":"3th5" }, { "sim":50.0, - "partner":"4gzm" + "partner":"4c76" }, { "sim":50.0, @@ -660205,10 +662995,6 @@ "sim":50.0, "partner":"4mpz" }, - { - "sim":50.0, - "partner":"3l1u" - }, { "sim":50.0, "partner":"3l1v" @@ -660225,6 +663011,10 @@ "sim":50.0, "partner":"3esr" }, + { + "sim":50.0, + "partner":"3l1u" + }, { "sim":50.0, "partner":"2wc9" @@ -660247,19 +663037,19 @@ }, { "sim":50.0, - "partner":"7fe0" + "partner":"7fe5" }, { "sim":50.0, - "partner":"7fe5" + "partner":"7fe0" }, { "sim":50.0, - "partner":"3oci" + "partner":"3oc3" }, { "sim":50.0, - "partner":"3oc3" + "partner":"3oci" }, { "sim":50.0, @@ -660267,11 +663057,11 @@ }, { "sim":50.0, - "partner":"7w83" + "partner":"7ocj" }, { "sim":50.0, - "partner":"7ocj" + "partner":"7w83" }, { "sim":50.0, @@ -660295,11 +663085,11 @@ }, { "sim":50.0, - "partner":"6z0x" + "partner":"6z0y" }, { "sim":50.0, - "partner":"6z0y" + "partner":"6z0x" }, { "sim":50.0, @@ -660351,31 +663141,31 @@ }, { "sim":50.0, - "partner":"6o98" + "partner":"7jh2" }, { "sim":50.0, - "partner":"7d9v" + "partner":"7d8h" }, { "sim":50.0, - "partner":"7d8p" + "partner":"6bn6" }, { "sim":50.0, - "partner":"7jh2" + "partner":"6xfv" }, { "sim":50.0, - "partner":"7d8h" + "partner":"7d9v" }, { "sim":50.0, - "partner":"6bn6" + "partner":"6o98" }, { "sim":50.0, - "partner":"6xfv" + "partner":"7d8p" }, { "sim":50.0, @@ -660463,11 +663253,11 @@ }, { "sim":50.0, - "partner":"2wk1" + "partner":"6akv" }, { "sim":50.0, - "partner":"6akv" + "partner":"2wk1" }, { "sim":50.0, @@ -660477,14 +663267,6 @@ "sim":50.0, "partner":"7dbs" }, - { - "sim":50.0, - "partner":"7kqj" - }, - { - "sim":50.0, - "partner":"6vqf" - }, { "sim":50.0, "partner":"7kxd" @@ -660523,24 +663305,32 @@ }, { "sim":50.0, - "partner":"1cbf" + "partner":"6u25" }, { "sim":50.0, - "partner":"6u25" + "partner":"7luk" }, { "sim":50.0, - "partner":"7luk" + "partner":"1cbf" }, { "sim":50.0, - "partner":"4rni" + "partner":"6vqf" + }, + { + "sim":50.0, + "partner":"7kqj" }, { "sim":50.0, "partner":"4rnj" }, + { + "sim":50.0, + "partner":"4rni" + }, { "sim":50.0, "partner":"5ldb" @@ -660581,10 +663371,6 @@ "sim":50.0, "partner":"6zzt" }, - { - "sim":50.0, - "partner":"4bwa" - }, { "sim":50.0, "partner":"2zim" @@ -660665,6 +663451,10 @@ "sim":50.0, "partner":"4bw9" }, + { + "sim":50.0, + "partner":"4bwa" + }, { "sim":50.0, "partner":"6y61" @@ -660693,10 +663483,6 @@ "sim":50.0, "partner":"2oz5" }, - { - "sim":50.0, - "partner":"4rtl" - }, { "sim":50.0, "partner":"4rtm" @@ -660739,15 +663525,15 @@ }, { "sim":50.0, - "partner":"3nha" + "partner":"4rtl" }, { "sim":50.0, - "partner":"3nhb" + "partner":"8tez" }, { "sim":50.0, - "partner":"8tez" + "partner":"3nh6" }, { "sim":50.0, @@ -660759,11 +663545,15 @@ }, { "sim":50.0, - "partner":"3nh6" + "partner":"3nh9" }, { "sim":50.0, - "partner":"3nh9" + "partner":"3nha" + }, + { + "sim":50.0, + "partner":"3nhb" }, { "sim":50.0, @@ -660787,24 +663577,20 @@ }, { "sim":50.0, - "partner":"1g8o" + "partner":"3zgd" }, { "sim":50.0, - "partner":"1fg5" + "partner":"1g8o" }, { "sim":50.0, - "partner":"3zgd" + "partner":"1fg5" }, { "sim":50.0, "partner":"1g93" }, - { - "sim":50.0, - "partner":"3g3d" - }, { "sim":50.0, "partner":"3bvj" @@ -660831,12 +663617,16 @@ }, { "sim":50.0, - "partner":"3el6" + "partner":"3g3d" }, { "sim":50.0, "partner":"6nr1" }, + { + "sim":50.0, + "partner":"3el6" + }, { "sim":50.0, "partner":"7e4m" @@ -660887,11 +663677,11 @@ }, { "sim":50.0, - "partner":"6lcn" + "partner":"7x1l" }, { "sim":50.0, - "partner":"7x1l" + "partner":"6lcn" }, { "sim":50.0, @@ -660911,11 +663701,11 @@ }, { "sim":50.0, - "partner":"7cje" + "partner":"7cjg" }, { "sim":50.0, - "partner":"7cjg" + "partner":"7cje" }, { "sim":50.0, @@ -660941,14 +663731,6 @@ "sim":50.0, "partner":"7r2e" }, - { - "sim":50.0, - "partner":"4h2w" - }, - { - "sim":50.0, - "partner":"3mey" - }, { "sim":50.0, "partner":"4h2x" @@ -660983,20 +663765,24 @@ }, { "sim":50.0, - "partner":"4l3f" + "partner":"4h2w" }, { "sim":50.0, - "partner":"7cm8" + "partner":"3mey" }, { "sim":50.0, - "partner":"7djq" + "partner":"4l3f" }, { "sim":50.0, "partner":"7c35" }, + { + "sim":50.0, + "partner":"7ewo" + }, { "sim":50.0, "partner":"6aif" @@ -661011,7 +663797,7 @@ }, { "sim":50.0, - "partner":"7ewo" + "partner":"7cm8" }, { "sim":50.0, @@ -661019,19 +663805,19 @@ }, { "sim":50.0, - "partner":"7cxs" + "partner":"7djq" }, { "sim":50.0, - "partner":"7cxu" + "partner":"7cxs" }, { "sim":50.0, - "partner":"7cxv" + "partner":"7cxu" }, { "sim":50.0, - "partner":"2ikf" + "partner":"7cxv" }, { "sim":50.0, @@ -661063,11 +663849,7 @@ }, { "sim":50.0, - "partner":"1x19" - }, - { - "sim":50.0, - "partner":"1x1a" + "partner":"2ikf" }, { "sim":50.0, @@ -661081,6 +663863,14 @@ "sim":50.0, "partner":"1x1d" }, + { + "sim":50.0, + "partner":"1x19" + }, + { + "sim":50.0, + "partner":"1x1a" + }, { "sim":50.0, "partner":"7m4s" @@ -661097,10 +663887,6 @@ "sim":50.0, "partner":"6clx" }, - { - "sim":50.0, - "partner":"4m1i" - }, { "sim":50.0, "partner":"4d8f" @@ -661113,6 +663899,10 @@ "sim":50.0, "partner":"4m1h" }, + { + "sim":50.0, + "partner":"4m1i" + }, { "sim":50.0, "partner":"4o6e" @@ -661145,10 +663935,6 @@ "sim":50.0, "partner":"6rfo" }, - { - "sim":50.0, - "partner":"2iua" - }, { "sim":50.0, "partner":"2iu8" @@ -661159,15 +663945,15 @@ }, { "sim":50.0, - "partner":"2nqo" + "partner":"2iua" }, { "sim":50.0, - "partner":"6rfp" + "partner":"2nqo" }, { "sim":50.0, - "partner":"6put" + "partner":"6rfp" }, { "sim":50.0, @@ -661181,21 +663967,17 @@ "sim":50.0, "partner":"6v3k" }, - { - "sim":50.0, - "partner":"5u1c" - }, { "sim":50.0, "partner":"6puz" }, { "sim":50.0, - "partner":"4q3r" + "partner":"5u1c" }, { "sim":50.0, - "partner":"4q42" + "partner":"6put" }, { "sim":50.0, @@ -661231,19 +664013,23 @@ }, { "sim":50.0, - "partner":"5j8x" + "partner":"4q3r" }, { "sim":50.0, - "partner":"6voy" + "partner":"4q42" }, { "sim":50.0, - "partner":"5vrd" + "partner":"5j8x" }, { "sim":50.0, - "partner":"7dib" + "partner":"6voy" + }, + { + "sim":50.0, + "partner":"5vrd" }, { "sim":50.0, @@ -661255,7 +664041,7 @@ }, { "sim":50.0, - "partner":"6jtl" + "partner":"7dib" }, { "sim":50.0, @@ -661271,12 +664057,16 @@ }, { "sim":50.0, - "partner":"7sc6" + "partner":"6jtl" }, { "sim":50.0, "partner":"7scq" }, + { + "sim":50.0, + "partner":"7sc6" + }, { "sim":50.0, "partner":"3au7" @@ -661331,11 +664121,11 @@ }, { "sim":50.0, - "partner":"5xw2" + "partner":"4e2p" }, { "sim":50.0, - "partner":"4e2p" + "partner":"5xw2" }, { "sim":50.0, @@ -661357,14 +664147,6 @@ "sim":50.0, "partner":"2wio" }, - { - "sim":50.0, - "partner":"6j87" - }, - { - "sim":50.0, - "partner":"6j88" - }, { "sim":50.0, "partner":"5y0n" @@ -661379,7 +664161,11 @@ }, { "sim":50.0, - "partner":"2ca0" + "partner":"6j87" + }, + { + "sim":50.0, + "partner":"6j88" }, { "sim":50.0, @@ -661407,11 +664193,7 @@ }, { "sim":50.0, - "partner":"2yhg" - }, - { - "sim":50.0, - "partner":"4q6q" + "partner":"2ca0" }, { "sim":50.0, @@ -661431,19 +664213,19 @@ }, { "sim":50.0, - "partner":"3amu" + "partner":"2yhg" }, { "sim":50.0, - "partner":"3amt" + "partner":"4q6q" }, { "sim":50.0, - "partner":"7xbn" + "partner":"3amt" }, { "sim":50.0, - "partner":"7xbo" + "partner":"3amu" }, { "sim":50.0, @@ -661451,48 +664233,40 @@ }, { "sim":50.0, - "partner":"3tkt" - }, - { - "sim":50.0, - "partner":"7jtj" + "partner":"7xbn" }, { "sim":50.0, - "partner":"7jua" + "partner":"7xbo" }, { "sim":50.0, - "partner":"4rnf" + "partner":"3tkt" }, { "sim":50.0, - "partner":"4rnh" + "partner":"7jtj" }, { "sim":50.0, - "partner":"4wya" + "partner":"7jua" }, { "sim":50.0, - "partner":"4wyf" + "partner":"4rnf" }, { "sim":50.0, - "partner":"4cxq" + "partner":"4rnh" }, { "sim":50.0, - "partner":"5kgs" + "partner":"4cxr" }, { "sim":50.0, "partner":"4wyg" }, - { - "sim":50.0, - "partner":"4cxr" - }, { "sim":50.0, "partner":"4xjl" @@ -661557,53 +664331,61 @@ "sim":50.0, "partner":"3tfu" }, + { + "sim":50.0, + "partner":"4wya" + }, { "sim":50.0, "partner":"4wye" }, { "sim":50.0, - "partner":"5tnu" + "partner":"4wyf" }, { "sim":50.0, - "partner":"6p4o" + "partner":"4cxq" }, { "sim":50.0, - "partner":"2zfn" + "partner":"5kgs" }, { "sim":50.0, - "partner":"7tfc" + "partner":"5tnu" }, { "sim":50.0, - "partner":"7tfe" + "partner":"6p4o" }, { "sim":50.0, - "partner":"7tf9" + "partner":"2zfn" }, { "sim":50.0, - "partner":"3cmj" + "partner":"7tfe" }, { "sim":50.0, - "partner":"7xb5" + "partner":"7tf9" }, { "sim":50.0, - "partner":"5y9h" + "partner":"7tfc" }, { "sim":50.0, - "partner":"6mlh" + "partner":"3cmj" }, { "sim":50.0, - "partner":"6mlw" + "partner":"7xb5" + }, + { + "sim":50.0, + "partner":"5y9h" }, { "sim":50.0, @@ -661629,6 +664411,14 @@ "sim":50.0, "partner":"6mlf" }, + { + "sim":50.0, + "partner":"6mlh" + }, + { + "sim":50.0, + "partner":"6mlw" + }, { "sim":50.0, "partner":"6j0u" @@ -661645,10 +664435,6 @@ "sim":50.0, "partner":"3taz" }, - { - "sim":50.0, - "partner":"6vy9" - }, { "sim":50.0, "partner":"6vya" @@ -661661,6 +664447,10 @@ "sim":50.0, "partner":"5xix" }, + { + "sim":50.0, + "partner":"6vy9" + }, { "sim":50.0, "partner":"4kc7" @@ -661675,11 +664465,11 @@ }, { "sim":50.0, - "partner":"7f79" + "partner":"7f77" }, { "sim":50.0, - "partner":"7f77" + "partner":"7f79" }, { "sim":50.0, @@ -661727,11 +664517,11 @@ }, { "sim":50.0, - "partner":"3mjv" + "partner":"6ta8" }, { "sim":50.0, - "partner":"6ta8" + "partner":"3mjv" }, { "sim":50.0, @@ -661747,11 +664537,11 @@ }, { "sim":50.0, - "partner":"4mdo" + "partner":"4mdp" }, { "sim":50.0, - "partner":"4mdp" + "partner":"4mdo" }, { "sim":50.0, @@ -661807,15 +664597,15 @@ }, { "sim":50.0, - "partner":"6qu3" + "partner":"6qu4" }, { "sim":50.0, - "partner":"6qu4" + "partner":"6qu5" }, { "sim":50.0, - "partner":"6qu5" + "partner":"6qu3" }, { "sim":50.0, @@ -661859,11 +664649,11 @@ }, { "sim":50.0, - "partner":"2vbg" + "partner":"2vbf" }, { "sim":50.0, - "partner":"2vbf" + "partner":"2vbg" }, { "sim":50.0, @@ -661887,15 +664677,15 @@ }, { "sim":50.0, - "partner":"5tsh" + "partner":"6olj" }, { "sim":50.0, - "partner":"6olj" + "partner":"5tsg" }, { "sim":50.0, - "partner":"5tsg" + "partner":"5tsh" }, { "sim":50.0, @@ -662009,10 +664799,6 @@ "sim":50.0, "partner":"8exd" }, - { - "sim":50.0, - "partner":"5t4a" - }, { "sim":50.0, "partner":"5t4c" @@ -662023,7 +664809,7 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"5t4a" }, { "sim":50.0, @@ -662033,6 +664819,10 @@ "sim":50.0, "partner":"6ee1" }, + { + "sim":50.0, + "partner":"6edw" + }, { "sim":50.0, "partner":"3slk" @@ -662292,96 +665082,96 @@ ], "subtitle":"De novo design of chlorophyll special pair containing protein assemblies", "tags":[ - "electron donor", - "photosynthetic", - "chlorophyll", + "de novo design", "de novo protein", - "de novo design" + "chlorophyll", + "photosynthetic", + "electron donor" ], "keywords":[ - "results", "accepts", - "imaging", - "suggest", - "independently", - "crystallography", - "designed", - "current", - "couple", + "technologies", "methods", + "separation", + "within", + "results", + "new", + "model", "chlorophyll", - "complexities", - "synthetic", - "c", - "structure", - "fluorescence", - "harvesting", + "protein", + "positions", + "microscopy", + "pair", + "initiates", + "confirmed", + "novo", "photophysics", - "proteins", - "reach", - "technologies", - "de", - "edge", - "conversion", - "orientation", + "systems", + "two", "binds", - "separation", + "special", + "using", + "creating", + "independently", + "reach", + "cascade", "step", - "excitation", - "positions", - "natural", - "pairs", - "excitonically", - "native", - "revealed", - "first", - "second", - "molecules", - "coupled", + "charge", + "matched", + "complexities", + "proteins", "unseen", + "2", + "conversion", "octahedral", - "systems", - "previously", - "investigate", - "special", - "toward", - "demonstrated", - "geometry", + "harvesting", + "suggest", "antenna", - "photosynthetic", - "artificial", - "closely", - "transfer", - "photosystems", + "computational", + "pairs", + "investigate", + "c", "design", - "model", - "using", - "initiates", "energy", - "juxtaposed", - "one", - "novo", - "chlorophylls", - "lifetime", - "hold", - "matched", - "charge", "spectroscopy", - "confirmed", - "two", - "arrangements", - "creating", + "current", + "hold", + "natural", + "edge", + "orientation", + "excitonically", + "chlorophylls", "light", - "protein", - "microscopy", - "2", - "within", - "computational", + "demonstrated", + "toward", + "whereas", + "couple", + "lifetime", "nanocage", - "cascade", - "pair", - "new", - "whereas" + "designed", + "fluorescence", + "photosystems", + "revealed", + "juxtaposed", + "coupled", + "one", + "geometry", + "de", + "photosynthetic", + "first", + "previously", + "imaging", + "structure", + "synthetic", + "closely", + "crystallography", + "excitation", + "molecules", + "artificial", + "native", + "arrangements", + "second", + "transfer" ], "release_date":"2024-05-15", "publication":"\"De novo design of proteins housing excitonically coupled chlorophyll special pairs\", Nat.Chem.Biol., 20, 906-915", @@ -662574,86 +665364,86 @@ ], "subtitle":"Top-down design of protein architectures with reinforcement learning", "tags":[ - "cryoem", - "capsid", + "de novo design", + "de novo protein", "rosetta", - "nanoparticle", "oligomer", - "de novo protein", "reinforcement learning", - "de novo design" + "nanoparticle", + "capsid", + "cryoem" ], "keywords":[ - "sample", - "power", - "ultracompact", - "architectures", - "constraints", - "overall", - "specified", - "functional", - "solves", - "models", + "designed", + "complex", + "search", + "demonstrates", "enables", - "architecture", - "conformers", + "often", "complementarity", + "naturally", + "design", + "models", + "specified", + "signaling", + "context", "immunogens", - "assemblies", - "approach", - "generate", - "substantial", + "angiogenesis", + "fit", + "icosohedra", "reinforcement", - "nanopores", - "close", - "icosahedra", "selection", - "search", - "signaling", + "learning", + "current", + "structures", + "functional", + "evolutionary", + "approaches", + "display", + "overall", + "ultracompact", + "properties", + "icosahedra", + "shape", + "solves", + "tree", + "protein", "potentiates", - "manner", - "achievable", - "carlo", + "architectures", + "function", + "approach", + "monte", "response", - "angiogenesis", - "desired", - "shape", + "molecules", + "microscopy", + "close", "together", - "monte", - "designed", "enable", - "induction", - "approaches", - "demonstrates", - "current", - "optimal", - "problem", + "architecture", + "nanomaterials", + "manner", + "constraints", + "nanopores", "system", - "evolutionary", - "occurring", - "often", + "sample", "result", - "design", - "structures", - "naturally", - "protein", - "using", - "microscopy", - "context", - "complex", - "describe", - "nanomaterials", - "function", - "display", + "power", + "induction", "subunits", - "fit", + "achievable", + "conformers", + "problem", "vaccine", + "describe", + "assemblies", + "optimal", + "desired", + "substantial", "computational", - "learning", - "molecules", - "tree", - "icosohedra", - "properties" + "using", + "generate", + "occurring", + "carlo" ], "release_date":"2023-05-10", "publication":"\"Top-down design of protein architectures with reinforcement learning\", Science, 380, 266-273", @@ -662822,85 +665612,85 @@ ], "subtitle":"Top-down design of protein architectures with reinforcement learning", "tags":[ - "capsid", + "de novo design", + "de novo protein", "rosetta", - "nanoparticle", "oligomer", - "de novo protein", "reinforcement learning", - "de novo design" + "nanoparticle", + "capsid" ], "keywords":[ - "sample", - "power", - "ultracompact", - "architectures", - "constraints", - "overall", - "specified", - "functional", - "solves", - "models", + "designed", + "complex", + "search", + "demonstrates", "enables", - "architecture", - "conformers", + "often", "complementarity", + "naturally", + "design", + "models", + "specified", + "signaling", + "context", "immunogens", - "assemblies", - "approach", - "generate", - "substantial", + "angiogenesis", + "fit", + "icosohedra", "reinforcement", - "nanopores", - "close", - "icosahedra", "selection", - "search", - "signaling", + "learning", + "current", + "structures", + "functional", + "evolutionary", + "approaches", + "display", + "overall", + "ultracompact", + "properties", + "icosahedra", + "shape", + "solves", + "tree", + "protein", "potentiates", - "manner", - "achievable", - "carlo", + "architectures", + "function", + "approach", + "monte", "response", - "angiogenesis", - "desired", - "shape", + "molecules", + "microscopy", + "close", "together", - "monte", - "designed", "enable", - "induction", - "approaches", - "demonstrates", - "current", - "optimal", - "problem", + "architecture", + "nanomaterials", + "manner", + "constraints", + "nanopores", "system", - "evolutionary", - "occurring", - "often", + "sample", "result", - "design", - "structures", - "naturally", - "protein", - "using", - "microscopy", - "context", - "complex", - "describe", - "nanomaterials", - "function", - "display", + "power", + "induction", "subunits", - "fit", + "achievable", + "conformers", + "problem", "vaccine", + "describe", + "assemblies", + "optimal", + "desired", + "substantial", "computational", - "learning", - "molecules", - "tree", - "icosohedra", - "properties" + "using", + "generate", + "occurring", + "carlo" ], "release_date":"2023-05-10", "publication":"\"Top-down design of protein architectures with reinforcement learning\", Science, 380, 266-273", @@ -663063,85 +665853,85 @@ ], "subtitle":"Top-down design of protein architectures with reinforcement learning", "tags":[ - "capsid", + "de novo design", + "de novo protein", "rosetta", - "nanoparticle", "oligomer", - "de novo protein", "reinforcement learning", - "de novo design" + "nanoparticle", + "capsid" ], "keywords":[ - "sample", - "power", - "ultracompact", - "architectures", - "constraints", - "overall", - "specified", - "functional", - "solves", - "models", + "designed", + "complex", + "search", + "demonstrates", "enables", - "architecture", - "conformers", + "often", "complementarity", + "naturally", + "design", + "models", + "specified", + "signaling", + "context", "immunogens", - "assemblies", - "approach", - "generate", - "substantial", + "angiogenesis", + "fit", + "icosohedra", "reinforcement", - "nanopores", - "close", - "icosahedra", "selection", - "search", - "signaling", + "learning", + "current", + "structures", + "functional", + "evolutionary", + "approaches", + "display", + "overall", + "ultracompact", + "properties", + "icosahedra", + "shape", + "solves", + "tree", + "protein", "potentiates", - "manner", - "achievable", - "carlo", + "architectures", + "function", + "approach", + "monte", "response", - "angiogenesis", - "desired", - "shape", + "molecules", + "microscopy", + "close", "together", - "monte", - "designed", "enable", - "induction", - "approaches", - "demonstrates", - "current", - "optimal", - "problem", + "architecture", + "nanomaterials", + "manner", + "constraints", + "nanopores", "system", - "evolutionary", - "occurring", - "often", + "sample", "result", - "design", - "structures", - "naturally", - "protein", - "using", - "microscopy", - "context", - "complex", - "describe", - "nanomaterials", - "function", - "display", + "power", + "induction", "subunits", - "fit", + "achievable", + "conformers", + "problem", "vaccine", + "describe", + "assemblies", + "optimal", + "desired", + "substantial", "computational", - "learning", - "molecules", - "tree", - "icosohedra", - "properties" + "using", + "generate", + "occurring", + "carlo" ], "release_date":"2023-05-10", "publication":"\"Top-down design of protein architectures with reinforcement learning\", Science, 380, 266-273", @@ -663393,99 +666183,99 @@ ], "subtitle":"Cryoem structure of designed modular protein oligomer c8-71", "tags":[ - "self-assembling", "helical repeats", - "oligomeric", "de novo protein", - "synthetic" + "oligomeric", + "synthetic", + "self-assembling" ], "keywords":[ - "many", - "specificity", - "developing", - "potent", - "signaling", - "scaffolds", - "developmental", - "valency", - "roles", - "designed", - "receptor", - "generated", - "initiating", + "driving", + "development", + "repeat", + "key", "agonists", - "complexities", - "synthetic", - "8", + "roles", + "extracellular", + "transphosphorylation", + "extended", + "tyrosine", + "affect", + "ligands", "splice", - "module", - "outcomes", - "repeat", - "broadly", - "building", - "therapeutic", - "cyclic", - "receptors", + "developing", + "vascular", + "protein", + "binding", + "fibroblast", + "domains", + "two", + "applications", "growth", - "cell", "cytokines", - "de", - "modularly", - "variants", - "mapk", - "transphosphorylation", - "vascular", + "outcomes", + "using", + "receptor", + "specificity", + "arterial", + "factors", + "release", + "cyclic", + "complexities", + "useful", "fgfr", - "driving", - "transitions", + "valency", + "blocks", + "factor", + "modular", + "cascades", + "activation", + "subunits", + "modularly", "future", - "signal", "ca", "exhibit", - "ligands", - "affect", + "signaling", + "intracellular", + "fates", + "transitions", + "therapeutic", + "mapk", + "cell", + "endothelium", + "incorporating", + "initiating", "series", - "early", + "downstream", + "broadly", + "pathway", + "building", "reveals", - "factors", - "release", - "geometry", + "developmental", "assemblies", - "extended", + "designed", + "many", + "perivascular", + "association", + "receptors", + "geometry", + "variants", "kinase", - "exploration", - "cascades", + "de", "unraveling", - "useful", - "endothelium", - "blocks", - "tyrosine", - "fibroblast", - "using", - "fates", - "applications", - "association", - "extracellular", - "high", - "subunits", - "perivascular", - "key", - "factor", - "pathway", - "intracellular", - "enable", - "modular", - "two", + "module", + "synthetic", + "scaffolds", + "exploration", + "signal", "systematic", - "incorporating", - "domains", - "downstream", - "protein", - "arterial", - "development", + "enable", + "high", "distinct", - "activation", - "binding" + "early", + "generated", + "potent", + "8" ], "release_date":"2023-11-29", "publication":"\"Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies\", Cell, 187, 3726-3740.e43", @@ -663774,99 +666564,99 @@ ], "subtitle":"Cryoem structure of designed modular protein oligomer c6-79", "tags":[ - "self-assembling", "helical repeats", - "oligomeric", "de novo protein", - "synthetic" + "oligomeric", + "synthetic", + "self-assembling" ], "keywords":[ - "many", - "specificity", - "developing", - "potent", - "signaling", - "scaffolds", - "developmental", - "valency", - "roles", - "designed", - "receptor", - "generated", - "initiating", + "driving", + "development", + "repeat", + "key", "agonists", - "complexities", - "synthetic", - "8", + "roles", + "extracellular", + "transphosphorylation", + "extended", + "tyrosine", + "affect", + "ligands", "splice", - "module", - "outcomes", - "repeat", - "broadly", - "building", - "therapeutic", - "cyclic", - "receptors", + "developing", + "vascular", + "protein", + "binding", + "fibroblast", + "domains", + "two", + "applications", "growth", - "cell", "cytokines", - "de", - "modularly", - "variants", - "mapk", - "transphosphorylation", - "vascular", + "outcomes", + "using", + "receptor", + "specificity", + "arterial", + "factors", + "release", + "cyclic", + "complexities", + "useful", "fgfr", - "driving", - "transitions", + "valency", + "blocks", + "factor", + "modular", + "cascades", + "activation", + "subunits", + "modularly", "future", - "signal", "ca", "exhibit", - "ligands", - "affect", + "signaling", + "intracellular", + "fates", + "transitions", + "therapeutic", + "mapk", + "cell", + "endothelium", + "incorporating", + "initiating", "series", - "early", + "downstream", + "broadly", + "pathway", + "building", "reveals", - "factors", - "release", - "geometry", + "developmental", "assemblies", - "extended", + "designed", + "many", + "perivascular", + "association", + "receptors", + "geometry", + "variants", "kinase", - "exploration", - "cascades", + "de", "unraveling", - "useful", - "endothelium", - "blocks", - "tyrosine", - "fibroblast", - "using", - "fates", - "applications", - "association", - "extracellular", - "high", - "subunits", - "perivascular", - "key", - "factor", - "pathway", - "intracellular", - "enable", - "modular", - "two", + "module", + "synthetic", + "scaffolds", + "exploration", + "signal", "systematic", - "incorporating", - "domains", - "downstream", - "protein", - "arterial", - "development", + "enable", + "high", "distinct", - "activation", - "binding" + "early", + "generated", + "potent", + "8" ], "release_date":"2023-11-29", "publication":"\"Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies\", Cell, 187, 3726-3740.e43", @@ -664147,104 +666937,104 @@ ], "subtitle":"Accurate computational design of genetically encoded 3d protein crystals", "tags":[ - "3d protein crystals", - "genetically encoded", "de novo protein", - "de novo design" + "3d protein crystals", + "de novo design", + "genetically encoded" ], "keywords":[ + "unpredictable", "largely", - "oligomers", - "architecture", - "systematically", - "challenge", - "designed", - "lattice", - "dimensions", + "engineering", + "role", + "structural", + "number", + "outstanding", + "information", + "group", + "three", "mixing", - "provide", - "unpredictable", + "degrees", + "protein", + "across", + "general", "purified", "crystal", - "extremely", - "sequences", - "interactions", - "designing", - "primary", - "porous", + "stable", + "100", + "corresponding", + "encoded", + "enables", + "engineered", + "nearly", + "overall", + "biological", + "specific", + "prespecified", "contacts", + "extremely", + "approach", "develop", - "interfaces", - "general", - "architectures", - "models", - "redesigned", - "cell", - "enables", + "packing", "process", - "outstanding", - "number", - "remains", + "accuracy", + "architecture", "highly", - "materials", - "structures", - "upon", - "empirical", - "atomic", + "freedom", + "computational", "pairs", - "three", - "hierarchically", - "corresponding", - "assembly", - "biology", - "nearly", - "role", - "preferences", + "designing", + "symmetry", + "design", + "individually", "\u00b5m", + "redesigned", + "atomic", + "biology", + "empirical", + "assembly", "platform", + "porous", + "preferences", + "precisely", + "cell", + "architectures", + "constrains", + "understood", + "spontaneously", + "primary", + "upon", + "system", + "retaining", + "crystals", + "identical", + "materials", + "hierarchically", + "designed", + "central", + "models", + "dimensions", + "poorly", + "sequences", + "space", + "interfaces", + "structures", + "oligomers", + "remains", "crystallization", - "plays", + "provide", "powerful", - "100", - "group", - "programming", - "freedom", - "information", "closely", - "specific", - "engineering", - "constrains", + "interactions", + "plays", + "programming", "unit", - "design", - "across", - "symmetry", + "lattice", "high", - "prespecified", - "encoded", - "biological", - "retaining", - "individually", - "packing", - "structural", - "accuracy", - "poorly", - "overall", "despite", - "approach", - "stable", - "engineered", - "understood", - "precisely", - "system", "arrangements", - "central", - "spontaneously", - "protein", - "degrees", - "identical", - "space", - "computational", - "crystals" + "challenge", + "systematically" ], "release_date":"2023-11-01", "publication":"\"Accurate computational design of three-dimensional protein crystals\", Nat Mater, 22, 1556-1563", @@ -664277,28 +667067,16 @@ "seq_thr_sim_designed":[ { "sim":410.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":410.0, - "partner":"8cus" + "partner":"8cut" }, { "sim":398.0, "partner":"8cwz" }, - { - "sim":355.0, - "partner":"9dnd" - }, - { - "sim":355.0, - "partner":"9dne" - }, - { - "sim":313.0, - "partner":"6xh5" - }, { "sim":244.0, "partner":"6b85" @@ -664313,11 +667091,11 @@ }, { "sim":100.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":100.0, - "partner":"8cqq" + "partner":"8cqp" }, { "sim":100.0, @@ -664325,27 +667103,27 @@ }, { "sim":100.0, - "partner":"8chy" + "partner":"8cmq" }, { "sim":100.0, - "partner":"8cmq" + "partner":"8bu0" }, { "sim":100.0, - "partner":"8ckr" + "partner":"8cp8" }, { "sim":100.0, - "partner":"8cig" + "partner":"8cqq" }, { "sim":100.0, - "partner":"8cqp" + "partner":"8chy" }, { "sim":100.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":98.0, @@ -664383,164 +667161,28 @@ "sim":83.0, "partner":"2wqh" }, - { - "sim":76.0, - "partner":"8umr" - }, { "sim":76.0, "partner":"8ump" - } - ], - "seq_thr_sim_natural":[ - { - "sim":376.0, - "partner":"1wa3" - }, - { - "sim":376.0, - "partner":"1vlw" - }, - { - "sim":370.0, - "partner":"8e01" - }, - { - "sim":367.0, - "partner":"5kp9" - }, - { - "sim":366.0, - "partner":"8a8n" - }, - { - "sim":362.0, - "partner":"7b3y" - }, - { - "sim":361.0, - "partner":"8ed3" - }, - { - "sim":345.0, - "partner":"8ejh" - }, - { - "sim":345.0, - "partner":"8ejd" - }, - { - "sim":345.0, - "partner":"8eji" - }, - { - "sim":345.0, - "partner":"8ejf" - }, - { - "sim":345.0, - "partner":"7sgd" - }, - { - "sim":345.0, - "partner":"7sge" - }, - { - "sim":345.0, - "partner":"7sgf" - }, - { - "sim":344.0, - "partner":"6p6f" - }, - { - "sim":109.0, - "partner":"8di1" - }, - { - "sim":108.0, - "partner":"2v81" - }, - { - "sim":108.0, - "partner":"2v82" - }, - { - "sim":105.0, - "partner":"3vcr" - }, - { - "sim":104.0, - "partner":"2yw3" - }, - { - "sim":104.0, - "partner":"2yw4" - }, - { - "sim":102.0, - "partner":"5im5" - }, - { - "sim":98.0, - "partner":"4qcc" - }, - { - "sim":96.0, - "partner":"6ovi" - }, - { - "sim":95.0, - "partner":"4e38" - }, - { - "sim":94.0, - "partner":"1vhc" - }, - { - "sim":89.0, - "partner":"1eun" - }, - { - "sim":89.0, - "partner":"1eua" - }, - { - "sim":89.0, - "partner":"1fq0" - }, - { - "sim":88.0, - "partner":"1wau" - }, - { - "sim":87.0, - "partner":"1wbh" - }, - { - "sim":87.0, - "partner":"2c0a" }, { - "sim":86.0, - "partner":"4bk9" - }, - { - "sim":85.0, - "partner":"5xse" + "sim":76.0, + "partner":"8umr" }, { - "sim":85.0, - "partner":"5xsf" + "sim":355.0, + "partner":"9dne" }, { - "sim":85.0, - "partner":"1fwr" + "sim":355.0, + "partner":"9dnd" }, { - "sim":85.0, - "partner":"1mxs" - }, + "sim":313.0, + "partner":"6xh5" + } + ], + "seq_thr_sim_natural":[ { "sim":100.0, "partner":"7obi" @@ -664573,10 +667215,6 @@ "sim":70.0, "partner":"7y4i" }, - { - "sim":70.0, - "partner":"8dtf" - }, { "sim":70.0, "partner":"8dtg" @@ -664590,12 +667228,12 @@ "partner":"8dti" }, { - "sim":64.0, - "partner":"2q7f" + "sim":70.0, + "partner":"8dtf" }, { "sim":64.0, - "partner":"4rg6" + "partner":"2q7f" }, { "sim":64.0, @@ -664607,11 +667245,7 @@ }, { "sim":64.0, - "partner":"5lcw" - }, - { - "sim":64.0, - "partner":"6q6g" + "partner":"4rg6" }, { "sim":64.0, @@ -664635,16 +667269,12 @@ }, { "sim":64.0, - "partner":"8pkp" + "partner":"6tlj" }, { "sim":64.0, "partner":"5l9u" }, - { - "sim":64.0, - "partner":"6tlj" - }, { "sim":64.0, "partner":"6q6h" @@ -664657,6 +667287,10 @@ "sim":64.0, "partner":"5a31" }, + { + "sim":64.0, + "partner":"8pkp" + }, { "sim":64.0, "partner":"5g05" @@ -664669,10 +667303,18 @@ "sim":64.0, "partner":"4ui9" }, + { + "sim":64.0, + "partner":"6q6g" + }, { "sim":64.0, "partner":"8tau" }, + { + "sim":64.0, + "partner":"5lcw" + }, { "sim":60.0, "partner":"3cvl" @@ -664701,10 +667343,6 @@ "sim":58.0, "partner":"2c0m" }, - { - "sim":58.0, - "partner":"4kyo" - }, { "sim":58.0, "partner":"3r9a" @@ -664717,25 +667355,29 @@ "sim":58.0, "partner":"4kxk" }, + { + "sim":58.0, + "partner":"4kyo" + }, { "sim":58.0, "partner":"1fch" }, { "sim":56.0, - "partner":"6voa" + "partner":"6vbu" }, { "sim":56.0, - "partner":"6vnw" + "partner":"6vbv" }, { "sim":56.0, - "partner":"6vbu" + "partner":"6voa" }, { "sim":56.0, - "partner":"6vbv" + "partner":"6vnw" }, { "sim":56.0, @@ -664764,6 +667406,154 @@ { "sim":51.0, "partner":"8a3t" + }, + { + "sim":376.0, + "partner":"1wa3" + }, + { + "sim":376.0, + "partner":"1vlw" + }, + { + "sim":370.0, + "partner":"8e01" + }, + { + "sim":367.0, + "partner":"5kp9" + }, + { + "sim":366.0, + "partner":"8a8n" + }, + { + "sim":362.0, + "partner":"7b3y" + }, + { + "sim":361.0, + "partner":"8ed3" + }, + { + "sim":345.0, + "partner":"8ejd" + }, + { + "sim":345.0, + "partner":"8eji" + }, + { + "sim":345.0, + "partner":"8ejf" + }, + { + "sim":345.0, + "partner":"8ejh" + }, + { + "sim":345.0, + "partner":"7sgd" + }, + { + "sim":345.0, + "partner":"7sge" + }, + { + "sim":345.0, + "partner":"7sgf" + }, + { + "sim":344.0, + "partner":"6p6f" + }, + { + "sim":109.0, + "partner":"8di1" + }, + { + "sim":108.0, + "partner":"2v81" + }, + { + "sim":108.0, + "partner":"2v82" + }, + { + "sim":105.0, + "partner":"3vcr" + }, + { + "sim":104.0, + "partner":"2yw3" + }, + { + "sim":104.0, + "partner":"2yw4" + }, + { + "sim":102.0, + "partner":"5im5" + }, + { + "sim":98.0, + "partner":"4qcc" + }, + { + "sim":96.0, + "partner":"6ovi" + }, + { + "sim":95.0, + "partner":"4e38" + }, + { + "sim":94.0, + "partner":"1vhc" + }, + { + "sim":89.0, + "partner":"1eun" + }, + { + "sim":89.0, + "partner":"1eua" + }, + { + "sim":89.0, + "partner":"1fq0" + }, + { + "sim":88.0, + "partner":"1wau" + }, + { + "sim":87.0, + "partner":"1wbh" + }, + { + "sim":87.0, + "partner":"2c0a" + }, + { + "sim":86.0, + "partner":"4bk9" + }, + { + "sim":85.0, + "partner":"5xse" + }, + { + "sim":85.0, + "partner":"5xsf" + }, + { + "sim":85.0, + "partner":"1fwr" + }, + { + "sim":85.0, + "partner":"1mxs" } ], "struct_thr_sim_designed":[ @@ -664796,7 +667586,7 @@ ], "seq_max_sim_designed":{ "sim":410.0, - "partner":"8cut" + "partner":"8cus" }, "seq_max_sim_natural":{ "sim":376.0, @@ -664943,84 +667733,84 @@ ], "subtitle":"Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains", "tags":[ - "protein assemblies", - "cryptic transmembrane domains", "negative design", "de novo protein", + "cryptic transmembrane domains", + "protein assemblies", "designed protein" ], "keywords":[ - "predicted", - "limit", - "stability", - "interfaces", - "general", - "without", - "poorly", - "advantageous", - "cryptic", - "practice", + "biotechnological", + "designed", + "form", "robustly", + "often", + "naturally", + "design", + "poorly", "many", - "suggesting", - "results", - "membrane", - "retroactive", - "components", - "assemblies", + "hydrophobic", + "interfaces", + "development", + "efficient", + "transmembrane", "secrete", - "improves", + "show", + "nanoparticle", + "sacrificing", "nanoparticles", - "efficient", + "computationally", + "vaccines", "biologics", - "designed", - "modular", - "may", - "would", - "pipelines", - "useful", + "previously", + "improves", + "secretion", + "machinery", + "assembly", + "platform", + "without", + "application", + "eukaryotic", + "degreaser", "protocol", - "sacrificing", + "retroactive", + "results", + "new", + "insertion", + "cryptic", + "recently", + "drive", + "protein", + "useful", + "stability", + "membrane", + "would", "develop", - "often", + "limit", + "interaction", + "modular", "occurring", - "application", + "general", + "may", + "cells", + "promising", "domains", - "show", - "drive", - "nanoparticle", - "design", - "previously", - "away", - "protein", - "secretion", + "predicted", + "broadly", "considerably", - "naturally", + "components", + "practice", + "pipelines", + "suggesting", "applications", - "hydrophobic", - "eukaryotic", - "insertion", - "development", "describe", - "promising", - "assembly", - "biotechnological", - "degreaser", - "emerged", - "computationally", - "broadly", - "recently", - "could", - "transmembrane", - "vaccines", - "form", - "computational", - "machinery", - "cells", + "assemblies", "integration", - "platform", - "new", - "interaction" + "away", + "computational", + "advantageous", + "could", + "emerged" ], "release_date":"2023-03-22", "publication":"\"Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains\", Proc.Natl.Acad.Sci.USA, 120, e2214556120-e2214556120", @@ -665313,84 +668103,84 @@ ], "subtitle":"Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains", "tags":[ - "protein assemblies", - "cryptic transmembrane domains", "negative design", "de novo protein", + "cryptic transmembrane domains", + "protein assemblies", "designed protein" ], "keywords":[ - "predicted", - "limit", - "stability", - "interfaces", - "general", - "without", - "poorly", - "advantageous", - "cryptic", - "practice", + "biotechnological", + "designed", + "form", "robustly", + "often", + "naturally", + "design", + "poorly", "many", - "suggesting", - "results", - "membrane", - "retroactive", - "components", - "assemblies", + "hydrophobic", + "interfaces", + "development", + "efficient", + "transmembrane", "secrete", - "improves", + "show", + "nanoparticle", + "sacrificing", "nanoparticles", - "efficient", + "computationally", + "vaccines", "biologics", - "designed", - "modular", - "may", - "would", - "pipelines", - "useful", + "previously", + "improves", + "secretion", + "machinery", + "assembly", + "platform", + "without", + "application", + "eukaryotic", + "degreaser", "protocol", - "sacrificing", + "retroactive", + "results", + "new", + "insertion", + "cryptic", + "recently", + "drive", + "protein", + "useful", + "stability", + "membrane", + "would", "develop", - "often", + "limit", + "interaction", + "modular", "occurring", - "application", + "general", + "may", + "cells", + "promising", "domains", - "show", - "drive", - "nanoparticle", - "design", - "previously", - "away", - "protein", - "secretion", + "predicted", + "broadly", "considerably", - "naturally", + "components", + "practice", + "pipelines", + "suggesting", "applications", - "hydrophobic", - "eukaryotic", - "insertion", - "development", "describe", - "promising", - "assembly", - "biotechnological", - "degreaser", - "emerged", - "computationally", - "broadly", - "recently", - "could", - "transmembrane", - "vaccines", - "form", - "computational", - "machinery", - "cells", + "assemblies", "integration", - "platform", - "new", - "interaction" + "away", + "computational", + "advantageous", + "could", + "emerged" ], "release_date":"2023-03-22", "publication":"\"Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains\", Proc.Natl.Acad.Sci.USA, 120, e2214556120-e2214556120", @@ -665627,84 +668417,84 @@ ], "subtitle":"Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains", "tags":[ - "protein assemblies", - "cryptic transmembrane domains", "negative design", "de novo protein", + "cryptic transmembrane domains", + "protein assemblies", "designed protein" ], "keywords":[ - "predicted", - "limit", - "stability", - "interfaces", - "general", - "without", - "poorly", - "advantageous", - "cryptic", - "practice", + "biotechnological", + "designed", + "form", "robustly", + "often", + "naturally", + "design", + "poorly", "many", - "suggesting", - "results", - "membrane", - "retroactive", - "components", - "assemblies", + "hydrophobic", + "interfaces", + "development", + "efficient", + "transmembrane", "secrete", - "improves", + "show", + "nanoparticle", + "sacrificing", "nanoparticles", - "efficient", + "computationally", + "vaccines", "biologics", - "designed", - "modular", - "may", - "would", - "pipelines", - "useful", + "previously", + "improves", + "secretion", + "machinery", + "assembly", + "platform", + "without", + "application", + "eukaryotic", + "degreaser", "protocol", - "sacrificing", + "retroactive", + "results", + "new", + "insertion", + "cryptic", + "recently", + "drive", + "protein", + "useful", + "stability", + "membrane", + "would", "develop", - "often", + "limit", + "interaction", + "modular", "occurring", - "application", + "general", + "may", + "cells", + "promising", "domains", - "show", - "drive", - "nanoparticle", - "design", - "previously", - "away", - "protein", - "secretion", + "predicted", + "broadly", "considerably", - "naturally", + "components", + "practice", + "pipelines", + "suggesting", "applications", - "hydrophobic", - "eukaryotic", - "insertion", - "development", "describe", - "promising", - "assembly", - "biotechnological", - "degreaser", - "emerged", - "computationally", - "broadly", - "recently", - "could", - "transmembrane", - "vaccines", - "form", - "computational", - "machinery", - "cells", + "assemblies", "integration", - "platform", - "new", - "interaction" + "away", + "computational", + "advantageous", + "could", + "emerged" ], "release_date":"2023-03-22", "publication":"\"Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains\", Proc.Natl.Acad.Sci.USA, 120, e2214556120-e2214556120", @@ -665922,84 +668712,84 @@ ], "subtitle":"Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains", "tags":[ - "protein assemblies", - "cryptic transmembrane domains", "negative design", "de novo protein", + "cryptic transmembrane domains", + "protein assemblies", "designed protein" ], "keywords":[ - "predicted", - "limit", - "stability", - "interfaces", - "general", - "without", - "poorly", - "advantageous", - "cryptic", - "practice", + "biotechnological", + "designed", + "form", "robustly", + "often", + "naturally", + "design", + "poorly", "many", - "suggesting", - "results", - "membrane", - "retroactive", - "components", - "assemblies", + "hydrophobic", + "interfaces", + "development", + "efficient", + "transmembrane", "secrete", - "improves", + "show", + "nanoparticle", + "sacrificing", "nanoparticles", - "efficient", + "computationally", + "vaccines", "biologics", - "designed", - "modular", - "may", - "would", - "pipelines", - "useful", + "previously", + "improves", + "secretion", + "machinery", + "assembly", + "platform", + "without", + "application", + "eukaryotic", + "degreaser", "protocol", - "sacrificing", + "retroactive", + "results", + "new", + "insertion", + "cryptic", + "recently", + "drive", + "protein", + "useful", + "stability", + "membrane", + "would", "develop", - "often", + "limit", + "interaction", + "modular", "occurring", - "application", + "general", + "may", + "cells", + "promising", "domains", - "show", - "drive", - "nanoparticle", - "design", - "previously", - "away", - "protein", - "secretion", + "predicted", + "broadly", "considerably", - "naturally", + "components", + "practice", + "pipelines", + "suggesting", "applications", - "hydrophobic", - "eukaryotic", - "insertion", - "development", "describe", - "promising", - "assembly", - "biotechnological", - "degreaser", - "emerged", - "computationally", - "broadly", - "recently", - "could", - "transmembrane", - "vaccines", - "form", - "computational", - "machinery", - "cells", + "assemblies", "integration", - "platform", - "new", - "interaction" + "away", + "computational", + "advantageous", + "could", + "emerged" ], "release_date":"2023-03-22", "publication":"\"Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains\", Proc.Natl.Acad.Sci.USA, 120, e2214556120-e2214556120", @@ -666216,84 +669006,84 @@ ], "subtitle":"Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains", "tags":[ - "protein assemblies", - "cryptic transmembrane domains", "negative design", "de novo protein", + "cryptic transmembrane domains", + "protein assemblies", "designed protein" ], "keywords":[ - "predicted", - "limit", - "stability", - "interfaces", - "general", - "without", - "poorly", - "advantageous", - "cryptic", - "practice", + "biotechnological", + "designed", + "form", "robustly", + "often", + "naturally", + "design", + "poorly", "many", - "suggesting", - "results", - "membrane", - "retroactive", - "components", - "assemblies", + "hydrophobic", + "interfaces", + "development", + "efficient", + "transmembrane", "secrete", - "improves", + "show", + "nanoparticle", + "sacrificing", "nanoparticles", - "efficient", + "computationally", + "vaccines", "biologics", - "designed", - "modular", - "may", - "would", - "pipelines", - "useful", + "previously", + "improves", + "secretion", + "machinery", + "assembly", + "platform", + "without", + "application", + "eukaryotic", + "degreaser", "protocol", - "sacrificing", + "retroactive", + "results", + "new", + "insertion", + "cryptic", + "recently", + "drive", + "protein", + "useful", + "stability", + "membrane", + "would", "develop", - "often", + "limit", + "interaction", + "modular", "occurring", - "application", + "general", + "may", + "cells", + "promising", "domains", - "show", - "drive", - "nanoparticle", - "design", - "previously", - "away", - "protein", - "secretion", + "predicted", + "broadly", "considerably", - "naturally", + "components", + "practice", + "pipelines", + "suggesting", "applications", - "hydrophobic", - "eukaryotic", - "insertion", - "development", "describe", - "promising", - "assembly", - "biotechnological", - "degreaser", - "emerged", - "computationally", - "broadly", - "recently", - "could", - "transmembrane", - "vaccines", - "form", - "computational", - "machinery", - "cells", + "assemblies", "integration", - "platform", - "new", - "interaction" + "away", + "computational", + "advantageous", + "could", + "emerged" ], "release_date":"2023-03-22", "publication":"\"Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains\", Proc.Natl.Acad.Sci.USA, 120, e2214556120-e2214556120", @@ -666506,76 +669296,76 @@ ], "subtitle":"Design of amyloidogenic peptide traps", "tags":[ + "de novo design", "amyloidogenic peptide", - "beta-strand", "de novo protein", - "amyloid fibrils", - "de novo design" + "beta-strand", + "amyloid fibrils" ], "keywords":[ - "general", - "designs", + "a\u03b2", + "designed", + "form", + "complex", "toxic", - "\u03b2", - "propensity", + "cognate", + "design", + "serum", "many", + "binders", + "implicated", + "de", + "cleft", + "tau", + "species", + "clefts", "tested", + "\u03b2", + "assembly", + "structure", + "scaffolds", + "block", + "model", + "nmr", + "state", + "antibodies", + "bind", + "approach", + "propensity", "proteins", - "reveals", - "a\u03b2", - "tau", - "protect", + "diseases", + "vitro", + "fibrils", + "transthyretin", + "a\u03b242", + "characterization", + "protected", + "close", "use", - "approach", - "potent", - "de", + "segments", + "high", + "general", "novo", - "close", - "clinically", + "cells", + "amyloid", "date", - "scaffolds", - "fibrils", + "reveals", + "apo", "peptides", - "designed", - "species", - "cognate", + "contain", + "conformations", "effectively", - "cleft", - "affinities", - "binders", - "implicated", + "potent", + "protect", "crystal", - "vitro", - "apo", - "state", - "a1", - "design", - "model", - "characterization", - "amyloid", + "describe", + "designs", "nanomolar", - "bind", + "affinities", + "a1", + "clinically", "using", - "complex", - "nmr", - "segments", - "describe", - "high", - "structure", - "a\u03b242", - "block", - "assembly", - "clefts", - "serum", - "diseases", - "form", - "cells", - "deep", - "protected", - "antibodies", - "conformations", - "contain", - "transthyretin" + "deep" ], "release_date":"2024-03-20", "publication":"\"Design of amyloidogenic peptide traps\", Nat.Chem.Biol., 20, 981-990", @@ -666753,74 +669543,74 @@ ], "subtitle":"Multi-state design of two-state switchable hinge proteins", "tags":[ - "protein dynamics", - "metamorphic proteins", + "switchable hinge proteins", "de novo protein", - "switchable hinge proteins" + "protein dynamics", + "metamorphic proteins" ], "keywords":[ - "accuracy", - "minima", - "double", - "control", - "devices", - "demonstrate", - "structured", - "ligand", - "despite", - "one", - "proteins", - "conformational", - "environmental", - "biochemical", - "sculpting", - "challenge", - "response", - "manner", - "crystallography", - "equilibria", - "information", + "measurements", "designed", - "electron", + "transistors", + "designing", + "populate", + "coupled", + "design", + "energy", + "conformational", + "one", + "structural", + "atomic", "spectroscopy", - "switch", - "stimuli", + "structurally", + "information", + "absence", "presence", - "flow", - "requires", - "landscape", + "computing", + "ligand", + "differences", + "structured", + "level", "closely", - "two", - "fully", - "absence", + "crystallography", + "control", + "protein", "nature", "state", + "biochemical", + "proteins", + "response", "transduce", - "hinge", - "populate", - "design", - "significant", - "protein", - "transistors", + "electron", + "binding", + "fully", + "accuracy", "microscopy", - "states", - "designing", - "describe", - "differences", - "structurally", + "analogous", + "manner", + "demonstrate", + "requires", "resonance", - "atomic", - "energy", "distinct", - "measurements", - "analogous", - "second", - "coupled", + "hinge", + "states", + "equilibria", + "landscape", + "sculpting", + "flow", "conformations", - "binding", - "structural", - "computing", - "level" + "two", + "switch", + "minima", + "despite", + "stimuli", + "environmental", + "devices", + "describe", + "challenge", + "second", + "double", + "significant" ], "release_date":"2023-08-16", "publication":"\"Design of stimulus-responsive two-state hinge proteins\", Science, 381, 754-760", @@ -667001,74 +669791,74 @@ ], "subtitle":"Multi-state design of two-state switchable hinge proteins", "tags":[ - "protein dynamics", - "metamorphic proteins", + "switchable hinge proteins", "de novo protein", - "switchable hinge proteins" + "protein dynamics", + "metamorphic proteins" ], "keywords":[ - "accuracy", - "minima", - "double", - "control", - "devices", - "demonstrate", - "structured", - "ligand", - "despite", - "one", - "proteins", - "conformational", - "environmental", - "biochemical", - "sculpting", - "challenge", - "response", - "manner", - "crystallography", - "equilibria", - "information", + "measurements", "designed", - "electron", + "transistors", + "designing", + "populate", + "coupled", + "design", + "energy", + "conformational", + "one", + "structural", + "atomic", "spectroscopy", - "switch", - "stimuli", + "structurally", + "information", + "absence", "presence", - "flow", - "requires", - "landscape", + "computing", + "ligand", + "differences", + "structured", + "level", "closely", - "two", - "fully", - "absence", + "crystallography", + "control", + "protein", "nature", "state", + "biochemical", + "proteins", + "response", "transduce", - "hinge", - "populate", - "design", - "significant", - "protein", - "transistors", + "electron", + "binding", + "fully", + "accuracy", "microscopy", - "states", - "designing", - "describe", - "differences", - "structurally", + "analogous", + "manner", + "demonstrate", + "requires", "resonance", - "atomic", - "energy", "distinct", - "measurements", - "analogous", - "second", - "coupled", + "hinge", + "states", + "equilibria", + "landscape", + "sculpting", + "flow", "conformations", - "binding", - "structural", - "computing", - "level" + "two", + "switch", + "minima", + "despite", + "stimuli", + "environmental", + "devices", + "describe", + "challenge", + "second", + "double", + "significant" ], "release_date":"2023-08-16", "publication":"\"Design of stimulus-responsive two-state hinge proteins\", Science, 381, 754-760", @@ -667297,74 +670087,74 @@ ], "subtitle":"Multi-state design of two-state switchable hinge proteins", "tags":[ - "protein dynamics", - "metamorphic proteins", + "switchable hinge proteins", "de novo protein", - "switchable hinge proteins" + "protein dynamics", + "metamorphic proteins" ], "keywords":[ - "accuracy", - "minima", - "double", - "control", - "devices", - "demonstrate", - "structured", - "ligand", - "despite", - "one", - "proteins", - "conformational", - "environmental", - "biochemical", - "sculpting", - "challenge", - "response", - "manner", - "crystallography", - "equilibria", - "information", + "measurements", "designed", - "electron", + "transistors", + "designing", + "populate", + "coupled", + "design", + "energy", + "conformational", + "one", + "structural", + "atomic", "spectroscopy", - "switch", - "stimuli", + "structurally", + "information", + "absence", "presence", - "flow", - "requires", - "landscape", + "computing", + "ligand", + "differences", + "structured", + "level", "closely", - "two", - "fully", - "absence", + "crystallography", + "control", + "protein", "nature", "state", + "biochemical", + "proteins", + "response", "transduce", - "hinge", - "populate", - "design", - "significant", - "protein", - "transistors", + "electron", + "binding", + "fully", + "accuracy", "microscopy", - "states", - "designing", - "describe", - "differences", - "structurally", + "analogous", + "manner", + "demonstrate", + "requires", "resonance", - "atomic", - "energy", "distinct", - "measurements", - "analogous", - "second", - "coupled", + "hinge", + "states", + "equilibria", + "landscape", + "sculpting", + "flow", "conformations", - "binding", - "structural", - "computing", - "level" + "two", + "switch", + "minima", + "despite", + "stimuli", + "environmental", + "devices", + "describe", + "challenge", + "second", + "double", + "significant" ], "release_date":"2023-08-16", "publication":"\"Design of stimulus-responsive two-state hinge proteins\", Science, 381, 754-760", @@ -667597,74 +670387,74 @@ ], "subtitle":"Multi-state design of two-state switchable hinge proteins", "tags":[ - "protein dynamics", - "metamorphic proteins", + "switchable hinge proteins", "de novo protein", - "switchable hinge proteins" + "protein dynamics", + "metamorphic proteins" ], "keywords":[ - "accuracy", - "minima", - "double", - "control", - "devices", - "demonstrate", - "structured", - "ligand", - "despite", - "one", - "proteins", - "conformational", - "environmental", - "biochemical", - "sculpting", - "challenge", - "response", - "manner", - "crystallography", - "equilibria", - "information", + "measurements", "designed", - "electron", + "transistors", + "designing", + "populate", + "coupled", + "design", + "energy", + "conformational", + "one", + "structural", + "atomic", "spectroscopy", - "switch", - "stimuli", + "structurally", + "information", + "absence", "presence", - "flow", - "requires", - "landscape", + "computing", + "ligand", + "differences", + "structured", + "level", "closely", - "two", - "fully", - "absence", + "crystallography", + "control", + "protein", "nature", "state", + "biochemical", + "proteins", + "response", "transduce", - "hinge", - "populate", - "design", - "significant", - "protein", - "transistors", + "electron", + "binding", + "fully", + "accuracy", "microscopy", - "states", - "designing", - "describe", - "differences", - "structurally", + "analogous", + "manner", + "demonstrate", + "requires", "resonance", - "atomic", - "energy", "distinct", - "measurements", - "analogous", - "second", - "coupled", + "hinge", + "states", + "equilibria", + "landscape", + "sculpting", + "flow", "conformations", - "binding", - "structural", - "computing", - "level" + "two", + "switch", + "minima", + "despite", + "stimuli", + "environmental", + "devices", + "describe", + "challenge", + "second", + "double", + "significant" ], "release_date":"2023-08-16", "publication":"\"Design of stimulus-responsive two-state hinge proteins\", Science, 381, 754-760", @@ -667753,11 +670543,11 @@ }, { "sim":64.0, - "partner":"6e9v" + "partner":"5cwn" }, { "sim":64.0, - "partner":"5cwn" + "partner":"6e9v" }, { "sim":64.0, @@ -667917,79 +670707,79 @@ ], "subtitle":"The five-repeat design e8", "tags":[ - "repeat proteins", "central pockets", - "pseudocyclic proteins", + "repeat proteins", "de novo protein", + "pseudocyclic proteins", "hallucination" ], "keywords":[ - "diverse", - "pseudocyclic", - "data", - "designs", - "ligand", - "\u03b2", - "channels", - "closed", - "proteins", - "models", - "rise", - "studies", - "coli", - "approach", - "barrels", - "exploring", - "close", - "single", - "pattern", - "devised", - "length", - "suggest", - "enzymes", - "enzymatic", "designed", - "number", - "serve", - "subunit", - "provide", - "binders", - "activity", - "folds", - "crystal", - "giving", "central", - "obtain", - "points", - "cavity", - "38", - "produced", - "design", - "helical", - "structures", "effective", - "space", - "pockets", "designing", - "specification", - "structurally", - "three", - "repeat", - "docking", + "pocket", "escherichia", - "diversity", - "broadly", + "models", + "design", + "space", + "specification", + "length", "transmembrane", + "repeat", + "number", + "cavity", + "diverse", + "structurally", + "structures", "able", + "single", + "closed", + "starting", + "binders", + "pattern", "inspired", - "pocket", - "repeated", - "binding", + "ligand", + "three", + "subunit", + "\u03b2", + "enzymatic", + "points", + "provide", + "serve", + "diversity", "cyclic", - "starting", + "docking", "biophysical", - "consistent", - "tim" + "exploring", + "pockets", + "approach", + "proteins", + "helical", + "binding", + "38", + "produced", + "close", + "enzymes", + "coli", + "activity", + "broadly", + "channels", + "suggest", + "tim", + "pseudocyclic", + "studies", + "repeated", + "data", + "crystal", + "devised", + "giving", + "designs", + "folds", + "rise", + "barrels", + "obtain", + "consistent" ], "release_date":"2023-09-27", "publication":"\"Hallucination of closed repeat proteins containing central pockets\", Nat.Struct.Mol.Biol., 30, 1755-1760", @@ -668122,79 +670912,79 @@ ], "subtitle":"The three-repeat design h10", "tags":[ - "repeat proteins", "central pockets", - "pseudocyclic proteins", + "repeat proteins", "de novo protein", + "pseudocyclic proteins", "hallucination" ], "keywords":[ - "diverse", - "pseudocyclic", - "data", - "designs", - "ligand", - "\u03b2", - "channels", - "closed", - "proteins", - "models", - "rise", - "studies", - "coli", - "approach", - "barrels", - "exploring", - "close", - "single", - "pattern", - "devised", - "length", - "suggest", - "enzymes", - "enzymatic", "designed", - "number", - "serve", - "subunit", - "provide", - "binders", - "activity", - "folds", - "crystal", - "giving", "central", - "obtain", - "points", - "cavity", - "38", - "produced", - "design", - "helical", - "structures", "effective", - "space", - "pockets", "designing", - "specification", - "structurally", - "three", - "repeat", - "docking", + "pocket", "escherichia", - "diversity", - "broadly", + "models", + "design", + "space", + "specification", + "length", "transmembrane", + "repeat", + "number", + "cavity", + "diverse", + "structurally", + "structures", "able", + "single", + "closed", + "starting", + "binders", + "pattern", "inspired", - "pocket", - "repeated", - "binding", + "ligand", + "three", + "subunit", + "\u03b2", + "enzymatic", + "points", + "provide", + "serve", + "diversity", "cyclic", - "starting", + "docking", "biophysical", - "consistent", - "tim" + "exploring", + "pockets", + "approach", + "proteins", + "helical", + "binding", + "38", + "produced", + "close", + "enzymes", + "coli", + "activity", + "broadly", + "channels", + "suggest", + "tim", + "pseudocyclic", + "studies", + "repeated", + "data", + "crystal", + "devised", + "giving", + "designs", + "folds", + "rise", + "barrels", + "obtain", + "consistent" ], "release_date":"2023-09-27", "publication":"\"Hallucination of closed repeat proteins containing central pockets\", Nat.Struct.Mol.Biol., 30, 1755-1760", @@ -668327,79 +671117,79 @@ ], "subtitle":"The two-repeat design h12", "tags":[ - "repeat proteins", "central pockets", - "pseudocyclic proteins", + "repeat proteins", "de novo protein", + "pseudocyclic proteins", "hallucination" ], "keywords":[ - "diverse", - "pseudocyclic", - "data", - "designs", - "ligand", - "\u03b2", - "channels", - "closed", - "proteins", - "models", - "rise", - "studies", - "coli", - "approach", - "barrels", - "exploring", - "close", - "single", - "pattern", - "devised", - "length", - "suggest", - "enzymes", - "enzymatic", "designed", - "number", - "serve", - "subunit", - "provide", - "binders", - "activity", - "folds", - "crystal", - "giving", "central", - "obtain", - "points", - "cavity", - "38", - "produced", - "design", - "helical", - "structures", "effective", - "space", - "pockets", "designing", - "specification", - "structurally", - "three", - "repeat", - "docking", + "pocket", "escherichia", - "diversity", - "broadly", + "models", + "design", + "space", + "specification", + "length", "transmembrane", + "repeat", + "number", + "cavity", + "diverse", + "structurally", + "structures", "able", + "single", + "closed", + "starting", + "binders", + "pattern", "inspired", - "pocket", - "repeated", - "binding", + "ligand", + "three", + "subunit", + "\u03b2", + "enzymatic", + "points", + "provide", + "serve", + "diversity", "cyclic", - "starting", + "docking", "biophysical", - "consistent", - "tim" + "exploring", + "pockets", + "approach", + "proteins", + "helical", + "binding", + "38", + "produced", + "close", + "enzymes", + "coli", + "activity", + "broadly", + "channels", + "suggest", + "tim", + "pseudocyclic", + "studies", + "repeated", + "data", + "crystal", + "devised", + "giving", + "designs", + "folds", + "rise", + "barrels", + "obtain", + "consistent" ], "release_date":"2023-09-27", "publication":"\"Hallucination of closed repeat proteins containing central pockets\", Nat.Struct.Mol.Biol., 30, 1755-1760", @@ -668473,129 +671263,154 @@ } ], "authors":[ + { + "forename":"S.", + "surname":"Lee" + }, { "forename":"R.D.", "surname":"Kibler" }, + { + "forename":"G.", + "surname":"Ahn" + }, + { + "forename":"Y.", + "surname":"Hsia" + }, + { + "forename":"A.J.", + "surname":"Borst" + }, + { + "forename":"A.", + "surname":"Philomin" + }, { "forename":"M.A.", "surname":"Kennedy" }, { - "forename":"B.L.", + "forename":"B.", + "surname":"Huang" + }, + { + "forename":"B.", "surname":"Stoddard" }, { - "forename":"S.", - "surname":"Lee" + "forename":"D.", + "surname":"Baker" } ], "classification":"unknown", "classification_suggested":[ - + "computational", + "deep-learning based" ], "classification_suggested_reason":[ - + "Author is: D. Baker" ], "subtitle":"De novo designed homotrimer; the fusion product of bgl17 and dhr59", "tags":[ - "computationally designed", - "tandem repeat protein", - "homotrimer", "designed", - "de novo protein", + "tandem repeat protein", "de novo", - "kibloid" + "de novo protein", + "kibloid", + "computationally designed", + "homotrimer" ], "keywords":[ - "nm", + "number", + "breaking", + "pseudosymmetrization", "multiple", + "group", + "c3", "route", + "delivery", + "candidates", "strategy", - "perfect", - "confirms", - "next", - "arranged", - "access", "triangulation", - "vehicles", - "vaccine", - "building", - "starting", - "interfaces", - "symmetries", + "protein", + "electron", + "next", + "microscopy", + "sophisticated", "general", - "architectures", - "viruses", - "similar", - "point", - "6", - "number", - "targeted", - "symmetric", - "nature", - "pseudosymmetrization", "75", - "trimeric", - "structures", - "octahedral", - "twenty", - "nanocages", - "generation", + "chains", + "similar", + "complex", "respectively", - "group", - "higher", - "generate", - "four", + "starting", + "closed", + "access", "trimers", - "4", - "cages", - "diameters", + "viruses", + "tetrahedral", "blocks", - "design", - "c3", - "explored", - "96", - "symmetry", - "describe", - "subunits", - "33", - "functionalities", - "candidates", - "breaking", - "sophisticated", - "delivery", - "chains", "eight", - "closed", - "240", + "confirms", + "octahedral", + "subunits", + "higher", + "four", + "icosahedral", + "symmetry", + "design", "similarly", - "appears", - "enable", - "electron", + "240", + "vehicles", "different", - "icosahedral", - "protein", - "tetrahedral", - "regular", - "microscopy", + "nm", + "nanocages", + "point", + "explored", + "architectures", + "symmetric", + "cages", + "arranged", + "functionalities", + "building", + "polyhedra", + "diameters", + "vaccine", + "describe", + "96", + "trimeric", + "generation", + "interfaces", + "6", + "targeted", + "structures", + "perfect", + "48", + "symmetries", + "twenty", "possess", - "complex", "43", + "nature", + "4", + "regular", + "enable", + "appears", "distinct", - "48", - "polyhedra" + "generate", + "33" ], "release_date":"2023-06-28", - "publication":"To be published", + "publication":"\"Four-component protein nanocages designed by programmed symmetry breaking\", Nature", "publication_ref":{ - "DOI":"", - "PubMed":"", - "CSD":"", - "ISSN":"", - "ASTM":"" + "DOI":"10.1038\/s41586-024-07814-1", + "PubMed":"39695226", + "CSD":"0006", + "ISSN":"1476-4687", + "ASTM":"NATUAS" }, - "publication_country":"", + "publication_country":"UK", "abstract":"Four, eight or twenty C3 symmetric protein trimers can be arranged with tetrahedral, octahedral or icosahedral point group symmetry to generate closed cage-like structures 1,2 . Viruses\u00a0access more complex higher triangulation number icosahedral architectures\u00a0by breaking perfect point group symmetry 3-9 , but nature appears not to have explored similar symmetry breaking for\u00a0tetrahedral or octahedral symmetries. Here we describe a general design strategy for building higher triangulation number architectures starting from\u00a0regular polyhedra through pseudosymmetrization of trimeric building blocks. Electron microscopy confirms the structures of T\u2009=\u20094 cages with 48 (tetrahedral), 96 (octahedral) and 240 (icosahedral) subunits, each with 4 distinct chains and 6 different protein-protein interfaces, and diameters of 33\u2009nm, 43\u2009nm and 75\u2009nm, respectively. Higher triangulation number viruses possess very sophisticated functionalities; our general route to higher triangulation number nanocages should similarly enable a next generation of multiple antigen-displaying vaccine candidates 10,11 and targeted delivery vehicles 12,13 .", "crystal_structure":{ "length_a":"153.477", @@ -668821,86 +671636,86 @@ ], "subtitle":"Designed loop protein rbl4", "tags":[ - "helical repeat", + "designed protein", "de novo protein", - "designed protein" + "helical repeat" ], "keywords":[ - "sites", - "buttressed", - "demonstrate", - "structured", - "designs", + "designed", + "achieve", + "form", + "central", + "flexibility", + "designing", + "thermally", "molecular", + "recognition", + "design", + "shows", + "models", + "however", + "functionality", "one", + "pocket", + "afforded", + "repeat", + "loop", + "binders", + "experimental", "loops", + "de", + "natural", "functional", - "proteins", - "irregularity", - "models", "multiple", - "monodisperse", - "transduction", - "de", - "novo", - "stable", - "close", - "extended", + "soluble", + "structures", + "agreement", "efforts", - "afforded", - "experimental", + "side", + "contribute", "roles", - "enzyme", - "designed", - "peptides", - "tandem", "buttressing", + "structured", "residues", - "highly", - "organizing", + "extended", + "new", + "transduction", "functions", - "difficult", - "agreement", - "flexibility", - "recognition", - "problem", - "binders", - "crystal", - "ability", - "folded", - "generally", - "central", - "bonding", - "design", - "functionality", - "characterization", - "regions", - "structures", - "protein", "interactions", - "soluble", + "protein", + "folded", + "signal", + "proteins", + "sites", "binding", - "natural", - "designing", - "describe", "solution", - "signal", - "repeat", - "thermally", - "form", + "generally", + "irregularity", + "characterization", + "monodisperse", + "close", + "tandem", "extensive", - "shows", - "however", - "side", - "pocket", - "achieve", - "catalysis", + "novo", + "ability", + "demonstrate", "hydrogen", - "characterizing", - "contribute", - "loop", + "enzyme", + "highly", "intrinsic", - "new" + "difficult", + "peptides", + "organizing", + "characterizing", + "buttressed", + "problem", + "stable", + "crystal", + "describe", + "designs", + "regions", + "catalysis", + "bonding" ], "release_date":"2024-04-17", "publication":"\"De novo design of buttressed loops for sculpting protein functions\", Nat.Chem.Biol., 20, 974-980", @@ -668973,11 +671788,11 @@ }, { "sim":93.0, - "partner":"2xeh" + "partner":"2xee" }, { "sim":93.0, - "partner":"2xee" + "partner":"2xeh" }, { "sim":93.0, @@ -669125,43 +671940,43 @@ }, { "sim":76.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":76.0, - "partner":"4j8y" + "partner":"9f8g" }, { "sim":76.0, - "partner":"8qea" + "partner":"8ql6" }, { "sim":76.0, - "partner":"4dui" + "partner":"8qla" }, { "sim":76.0, - "partner":"8ql9" + "partner":"8ql8" }, { "sim":76.0, - "partner":"8ql8" + "partner":"4dui" }, { "sim":76.0, - "partner":"8ql3" + "partner":"8qea" }, { "sim":76.0, - "partner":"9f8g" + "partner":"8qlb" }, { "sim":76.0, - "partner":"8ql6" + "partner":"8ql9" }, { "sim":76.0, - "partner":"8ql5" + "partner":"8ql7" }, { "sim":76.0, @@ -669169,15 +671984,15 @@ }, { "sim":76.0, - "partner":"8ql7" + "partner":"4j8y" }, { "sim":76.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":76.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":76.0, @@ -669205,7 +672020,7 @@ }, { "sim":74.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":74.0, @@ -669213,7 +672028,7 @@ }, { "sim":74.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":74.0, @@ -669253,11 +672068,15 @@ }, { "sim":64.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":64.0, - "partner":"7b4u" + "partner":"7b4v" + }, + { + "sim":61.0, + "partner":"9glq" }, { "sim":61.0, @@ -669337,10 +672156,6 @@ "sim":88.0, "partner":"6fp7" }, - { - "sim":88.0, - "partner":"8tzb" - }, { "sim":88.0, "partner":"8tzc" @@ -669363,12 +672178,16 @@ }, { "sim":88.0, - "partner":"5ma4" + "partner":"8tzb" }, { "sim":88.0, "partner":"5mak" }, + { + "sim":88.0, + "partner":"5ma4" + }, { "sim":88.0, "partner":"5ma5" @@ -669411,11 +672230,11 @@ }, { "sim":83.0, - "partner":"6mof" + "partner":"5ooy" }, { "sim":83.0, - "partner":"5ooy" + "partner":"6mof" }, { "sim":83.0, @@ -669449,10 +672268,6 @@ "sim":81.0, "partner":"6mok" }, - { - "sim":81.0, - "partner":"8g4f" - }, { "sim":81.0, "partner":"8g42" @@ -669469,6 +672284,10 @@ "sim":81.0, "partner":"8g3k" }, + { + "sim":81.0, + "partner":"8g4f" + }, { "sim":81.0, "partner":"6mwq" @@ -669513,49 +672332,25 @@ "sim":78.0, "partner":"2v5q" }, - { - "sim":78.0, - "partner":"5eno" - }, - { - "sim":78.0, - "partner":"6zob" - }, - { - "sim":78.0, - "partner":"5oyj" - }, - { - "sim":78.0, - "partner":"6zo5" - }, { "sim":78.0, "partner":"4dx6" }, { "sim":78.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":78.0, "partner":"6zoc" }, - { - "sim":78.0, - "partner":"5enp" - }, - { - "sim":78.0, - "partner":"6sgs" - }, { "sim":78.0, "partner":"6zo6" }, { "sim":78.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":78.0, @@ -669563,7 +672358,7 @@ }, { "sim":78.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":78.0, @@ -669571,11 +672366,11 @@ }, { "sim":78.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":78.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":78.0, @@ -669585,6 +672380,10 @@ "sim":78.0, "partner":"6zoe" }, + { + "sim":78.0, + "partner":"5enq" + }, { "sim":78.0, "partner":"6q4p" @@ -669595,19 +672394,19 @@ }, { "sim":78.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":78.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":78.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":78.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":78.0, @@ -669619,23 +672418,23 @@ }, { "sim":78.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":78.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":78.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":78.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":78.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":78.0, @@ -669647,15 +672446,15 @@ }, { "sim":78.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":78.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":78.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":78.0, @@ -669663,15 +672462,19 @@ }, { "sim":78.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":78.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":78.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":78.0, + "partner":"6sgr" }, { "sim":78.0, @@ -669687,12 +672490,28 @@ }, { "sim":78.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":78.0, "partner":"4dx5" }, + { + "sim":78.0, + "partner":"5eno" + }, + { + "sim":78.0, + "partner":"6zo5" + }, + { + "sim":78.0, + "partner":"5oyj" + }, + { + "sim":78.0, + "partner":"6q4n" + }, { "sim":78.0, "partner":"4hrl" @@ -669707,11 +672526,11 @@ }, { "sim":77.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":77.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":77.0, @@ -669731,11 +672550,11 @@ }, { "sim":77.0, - "partner":"2y1l" + "partner":"6gvm" }, { "sim":77.0, - "partner":"6gvm" + "partner":"2y1l" }, { "sim":77.0, @@ -669769,25 +672588,17 @@ "sim":76.0, "partner":"6bbn" }, - { - "sim":76.0, - "partner":"7yz0" - }, { "sim":76.0, "partner":"6mzf" }, { "sim":76.0, - "partner":"7yz1" - }, - { - "sim":76.0, - "partner":"7z01" + "partner":"5eyl" }, { "sim":76.0, - "partner":"5eyl" + "partner":"6mze" }, { "sim":76.0, @@ -669795,15 +672606,15 @@ }, { "sim":76.0, - "partner":"6mze" + "partner":"7yz2" }, { "sim":76.0, - "partner":"7yz2" + "partner":"7z02" }, { "sim":76.0, - "partner":"7z02" + "partner":"7ac5" }, { "sim":76.0, @@ -669811,19 +672622,19 @@ }, { "sim":76.0, - "partner":"2bkk" + "partner":"7yz3" }, { "sim":76.0, - "partner":"7ac5" + "partner":"2bkk" }, { "sim":76.0, - "partner":"7yz3" + "partner":"7yz5" }, { "sim":76.0, - "partner":"7yz5" + "partner":"7yz6" }, { "sim":76.0, @@ -669831,7 +672642,7 @@ }, { "sim":76.0, - "partner":"7yz6" + "partner":"6zwb" }, { "sim":76.0, @@ -669845,10 +672656,6 @@ "sim":76.0, "partner":"5nm5" }, - { - "sim":76.0, - "partner":"6zwb" - }, { "sim":76.0, "partner":"6gvn" @@ -669865,6 +672672,18 @@ "sim":76.0, "partner":"7yyz" }, + { + "sim":76.0, + "partner":"7yz0" + }, + { + "sim":76.0, + "partner":"7yz1" + }, + { + "sim":76.0, + "partner":"7z01" + }, { "sim":76.0, "partner":"6ne4" @@ -669909,10 +672728,6 @@ "sim":76.0, "partner":"6qfo" }, - { - "sim":75.0, - "partner":"7pd8" - }, { "sim":75.0, "partner":"7pdd" @@ -669925,6 +672740,10 @@ "sim":75.0, "partner":"7pdh" }, + { + "sim":75.0, + "partner":"7pd8" + }, { "sim":75.0, "partner":"7pje" @@ -669943,11 +672762,11 @@ }, { "sim":75.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":75.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":75.0, @@ -670027,11 +672846,11 @@ }, { "sim":73.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":73.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":73.0, @@ -670123,11 +672942,11 @@ }, { "sim":64.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":64.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":63.0, @@ -670249,14 +673068,6 @@ "sim":56.0, "partner":"6py8" }, - { - "sim":55.0, - "partner":"6m11" - }, - { - "sim":55.0, - "partner":"6m12" - }, { "sim":55.0, "partner":"6m13" @@ -670281,6 +673092,14 @@ "sim":55.0, "partner":"4o1p" }, + { + "sim":55.0, + "partner":"6m11" + }, + { + "sim":55.0, + "partner":"6m12" + }, { "sim":54.0, "partner":"1d9s" @@ -670323,15 +673142,15 @@ }, { "sim":50.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":50.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":50.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":50.0, @@ -670461,87 +673280,87 @@ ], "subtitle":"Homodimeric designed loop protein rbl7_c2_3", "tags":[ - "helical repeat", - "de novo protein", "designed protein", - "homodimer" + "de novo protein", + "homodimer", + "helical repeat" ], "keywords":[ - "sites", - "buttressed", - "demonstrate", - "structured", - "designs", + "designed", + "achieve", + "form", + "central", + "flexibility", + "designing", + "thermally", "molecular", + "recognition", + "design", + "shows", + "models", + "however", + "functionality", "one", + "pocket", + "afforded", + "repeat", + "loop", + "binders", + "experimental", "loops", + "de", + "natural", "functional", - "proteins", - "irregularity", - "models", "multiple", - "monodisperse", - "transduction", - "de", - "novo", - "stable", - "close", - "extended", + "soluble", + "structures", + "agreement", "efforts", - "afforded", - "experimental", + "side", + "contribute", "roles", - "enzyme", - "designed", - "peptides", - "tandem", "buttressing", + "structured", "residues", - "highly", - "organizing", + "extended", + "new", + "transduction", "functions", - "difficult", - "agreement", - "flexibility", - "recognition", - "problem", - "binders", - "crystal", - "ability", - "folded", - "generally", - "central", - "bonding", - "design", - "functionality", - "characterization", - "regions", - "structures", - "protein", "interactions", - "soluble", + "protein", + "folded", + "signal", + "proteins", + "sites", "binding", - "natural", - "designing", - "describe", "solution", - "signal", - "repeat", - "thermally", - "form", + "generally", + "irregularity", + "characterization", + "monodisperse", + "close", + "tandem", "extensive", - "shows", - "however", - "side", - "pocket", - "achieve", - "catalysis", + "novo", + "ability", + "demonstrate", "hydrogen", - "characterizing", - "contribute", - "loop", + "enzyme", + "highly", "intrinsic", - "new" + "difficult", + "peptides", + "organizing", + "characterizing", + "buttressed", + "problem", + "stable", + "crystal", + "describe", + "designs", + "regions", + "catalysis", + "bonding" ], "release_date":"2024-04-17", "publication":"\"De novo design of buttressed loops for sculpting protein functions\", Nat.Chem.Biol., 20, 974-980", @@ -670614,11 +673433,11 @@ }, { "sim":59.0, - "partner":"2xeh" + "partner":"2xee" }, { "sim":59.0, - "partner":"2xee" + "partner":"2xeh" }, { "sim":59.0, @@ -670870,75 +673689,75 @@ ], "subtitle":"Multi-state design of two-state switchable hinge proteins", "tags":[ - "metamorphic proteins", + "protein dynamics", "switchable hinge proteins", - "three-helix bundles", "de novo protein", - "protein dynamics" + "metamorphic proteins", + "three-helix bundles" ], "keywords":[ - "accuracy", - "minima", - "double", - "control", - "devices", - "demonstrate", - "structured", - "ligand", - "despite", - "one", - "proteins", - "conformational", - "environmental", - "biochemical", - "sculpting", - "challenge", - "response", - "manner", - "crystallography", - "equilibria", - "information", + "measurements", "designed", - "electron", + "transistors", + "designing", + "populate", + "coupled", + "design", + "energy", + "conformational", + "one", + "structural", + "atomic", "spectroscopy", - "switch", - "stimuli", + "structurally", + "information", + "absence", "presence", - "flow", - "requires", - "landscape", + "computing", + "ligand", + "differences", + "structured", + "level", "closely", - "two", - "fully", - "absence", + "crystallography", + "control", + "protein", "nature", "state", + "biochemical", + "proteins", + "response", "transduce", - "hinge", - "populate", - "design", - "significant", - "protein", - "transistors", + "electron", + "binding", + "fully", + "accuracy", "microscopy", - "states", - "designing", - "describe", - "differences", - "structurally", + "analogous", + "manner", + "demonstrate", + "requires", "resonance", - "atomic", - "energy", "distinct", - "measurements", - "analogous", - "second", - "coupled", + "hinge", + "states", + "equilibria", + "landscape", + "sculpting", + "flow", "conformations", - "binding", - "structural", - "computing", - "level" + "two", + "switch", + "minima", + "despite", + "stimuli", + "environmental", + "devices", + "describe", + "challenge", + "second", + "double", + "significant" ], "release_date":"2023-08-16", "publication":"\"Design of stimulus-responsive two-state hinge proteins\", Science, 381, 754-760", @@ -671091,96 +673910,96 @@ ], "subtitle":"Fast and versatile sequence- independent protein docking for nanomaterials design using rpxdock", "tags":[ - "cryoem", + "de novo design", + "de novo protein", "rosetta", "oligomer", - "de novo protein", - "interface", "octahedra", - "de novo design" + "cryoem", + "interface" ], "keywords":[ - "oligomers", - "results", - "available", - "use", - "potent", - "search", - "including", - "designed", - "lattice", - "uses", - "provide", - "current", - "fast", - "towards", - "methods", "score", - "software", - "designing", - "rpxdock", - "structure", + "rpx", + "development", + "methods", + "vaccines", + "practical", + "group", + "scoring", + "rapidly", + "results", + "new", "docking", - "computationally", - "novel", + "filtering", + "protein", + "across", + "promise", + "major", "body", - "cyclic", - "symmetries", - "hierarchical", - "architectures", - "tailored", + "variety", + "applications", + "modify", + "computationally", "configurations", + "specific", + "rigid", + "functions", + "cyclic", + "use", + "modular", + "available", "tools", - "rapidly", - "point", - "efficient", + "including", + "rpxdock", + "designing", + "symmetry", + "transform", + "classes", + "current", "used", - "difficult", - "rigid", + "multidimensional", "easily", - "materials", - "symmetric", - "transform", - "generation", - "considerable", - "guide", - "group", - "assemblies", - "filtering", - "method", - "refine", - "functions", + "point", + "architectures", "shown", - "specific", - "classes", - "scoring", - "rpx", - "promise", - "applications", - "across", - "symmetry", - "routes", - "describe", + "wide", + "symmetric", "functionalities", + "uses", + "describe", "range", - "one", - "wide", - "flexible", + "assemblies", + "materials", "desired", - "modular", - "multidimensional", - "guidelines", - "modify", - "protein", + "method", + "designed", + "search", + "generation", + "efficient", + "one", "space", - "variety", - "development", + "tailored", + "oligomers", + "symmetries", + "hierarchical", + "structure", + "provide", + "flexible", + "fast", "package", - "vaccines", - "practical", - "major", - "new", - "customizable" + "guidelines", + "customizable", + "software", + "refine", + "routes", + "considerable", + "lattice", + "towards", + "guide", + "difficult", + "potent", + "novel" ], "release_date":"2023-05-10", "publication":"\"Fast and versatile sequence-independent protein docking for nanomaterials design using RPXDock\", Plos Comput.Biol., 19, e1010680-e1010680", @@ -671245,19 +674064,19 @@ }, { "sim":123.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":123.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":122.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":122.0, - "partner":"8cqq" + "partner":"8cqp" }, { "sim":122.0, @@ -671265,27 +674084,27 @@ }, { "sim":122.0, - "partner":"8chy" + "partner":"8cmq" }, { "sim":122.0, - "partner":"8cmq" + "partner":"8bu0" }, { "sim":122.0, - "partner":"8ckr" + "partner":"8cp8" }, { "sim":122.0, - "partner":"8cig" + "partner":"8cqq" }, { "sim":122.0, - "partner":"8cqp" + "partner":"8chy" }, { "sim":122.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":121.0, @@ -671297,15 +674116,15 @@ }, { "sim":239.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":239.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":239.0, - "partner":"8cus" + "partner":"8cwz" }, { "sim":234.0, @@ -671321,11 +674140,11 @@ }, { "sim":62.0, - "partner":"7udm" + "partner":"7udn" }, { "sim":62.0, - "partner":"7udn" + "partner":"7udm" }, { "sim":105.0, @@ -671345,10 +674164,6 @@ "sim":72.0, "partner":"7y4i" }, - { - "sim":72.0, - "partner":"8dtf" - }, { "sim":72.0, "partner":"8dtg" @@ -671361,6 +674176,10 @@ "sim":72.0, "partner":"8dti" }, + { + "sim":72.0, + "partner":"8dtf" + }, { "sim":82.0, "partner":"1w3b" @@ -671373,10 +674192,6 @@ "sim":81.0, "partner":"6eou" }, - { - "sim":63.0, - "partner":"4rg6" - }, { "sim":63.0, "partner":"4rg7" @@ -671387,11 +674202,7 @@ }, { "sim":63.0, - "partner":"5lcw" - }, - { - "sim":63.0, - "partner":"6q6g" + "partner":"4rg6" }, { "sim":63.0, @@ -671415,11 +674226,11 @@ }, { "sim":63.0, - "partner":"5l9u" + "partner":"6tlj" }, { "sim":63.0, - "partner":"6tlj" + "partner":"5l9u" }, { "sim":63.0, @@ -671441,6 +674252,14 @@ "sim":63.0, "partner":"4ui9" }, + { + "sim":63.0, + "partner":"6q6g" + }, + { + "sim":63.0, + "partner":"5lcw" + }, { "sim":58.0, "partner":"3vtx" @@ -671455,15 +674274,15 @@ }, { "sim":51.0, - "partner":"8a5y" + "partner":"8a3t" }, { "sim":51.0, - "partner":"8a3t" + "partner":"8a61" }, { "sim":51.0, - "partner":"8a61" + "partner":"8a5y" }, { "sim":71.0, @@ -671477,10 +674296,6 @@ "sim":58.0, "partner":"2c0m" }, - { - "sim":58.0, - "partner":"4kyo" - }, { "sim":58.0, "partner":"3r9a" @@ -671493,25 +674308,29 @@ "sim":58.0, "partner":"4kxk" }, + { + "sim":58.0, + "partner":"4kyo" + }, { "sim":58.0, "partner":"1fch" }, { "sim":57.0, - "partner":"6voa" + "partner":"6vbu" }, { "sim":57.0, - "partner":"6vnw" + "partner":"6vbv" }, { "sim":57.0, - "partner":"6vbu" + "partner":"6voa" }, { "sim":57.0, - "partner":"6vbv" + "partner":"6vnw" }, { "sim":55.0, @@ -671547,10 +674366,6 @@ "sim":0.976000011, "partner":"6v8e" }, - { - "sim":0.9713000059, - "partner":"6vfh" - }, { "sim":0.9728999734, "partner":"8ump" @@ -671560,37 +674375,37 @@ "partner":"5hrz" }, { - "sim":0.961499989, - "partner":"6vl6" + "sim":0.9606999755, + "partner":"8far" }, { - "sim":0.9628000259, - "partner":"6vfk" + "sim":0.9713000059, + "partner":"6vfh" }, { - "sim":0.954400003, - "partner":"2hyz" + "sim":0.961499989, + "partner":"6vl6" }, { "sim":0.9578999877, "partner":"8chy" }, { - "sim":0.9538000226, - "partner":"8cqq" + "sim":0.9628000259, + "partner":"6vfk" }, { "sim":0.9617000222, "partner":"8cqp" }, - { - "sim":0.9606999755, - "partner":"8far" - }, { "sim":0.9559999704, "partner":"8ckr" }, + { + "sim":0.954400003, + "partner":"2hyz" + }, { "sim":0.9523000121, "partner":"6vfj" @@ -671602,6 +674417,10 @@ { "sim":0.9503999949, "partner":"8cig" + }, + { + "sim":0.9538000226, + "partner":"8cqq" } ], "struct_thr_sim_natural":[ @@ -671609,7 +674428,7 @@ ], "seq_max_sim_designed":{ "sim":239.0, - "partner":"8cut" + "partner":"8cus" }, "seq_max_sim_natural":{ "sim":159.0, @@ -671687,121 +674506,121 @@ ], "subtitle":"Ancestral protein ancth of phosphomethylpirimidine kinases family", "tags":[ - "enzyme evolution", - "5-phosphohydroxymethyl-2-methylpirimidine kinase", "transferase", "ancestral protein reconstruction", - "phosphomethylpirimidine kinases family" + "phosphomethylpirimidine kinases family", + "5-phosphohydroxymethyl-2-methylpirimidine kinase", + "enzyme evolution" ], "keywords":[ - "thermal", - "unfolding", - "cases", - "improve", - "many", - "results", - "architecture", - "frequently", - "use", - "vitamin", - "crystallography", - "allow", - "pathways", - "support", - "potential", - "correlates", - "interatomic", - "reconstruction", - "structure", - "contacts", - "identification", - "interaction", + "b1", "elucidation", - "combining", - "strategies", - "mesophilic", - "proteins", - "environmental", - "enzymes", - "kinases", - "family", - "biosynthetic", - "main", - "intensive", - "nonetheless", - "area", - "number", - "small", - "used", - "traits", - "easily", - "degree", - "ancestral", - "evolutionary", - "often", - "biophysics", - "highlight", - "dynamics", - "lead", - "natural", - "thermophilic", - "asr", + "engineering", "thermoadaptation", - "research", - "organisms", - "history", - "stability", - "homology", - "years", "molecular", - "functional", - "amino", - "making", - "trace", - "higher", - "temperature", - "identify", - "moreover", - "acids", - "challenging", - "approaches", - "simulations", - "engineering", - "counterparts", - "result", - "clear", - "bacteria", - "benefits", - "type", - "using", - "hydrophobic", - "high", - "responsible", - "sequence", - "increase", - "usually", "kinetic", + "allow", + "hydrophobic", "structural", + "number", + "strength", + "combining", + "biosynthetic", + "lead", + "mesophilic", + "results", + "protein", + "traits", + "given", + "clear", + "unfolding", "stabilization", - "pathway", - "b1", + "interatomic", "stable", - "success", - "highest", + "gained", "participate", + "using", + "simulations", + "improve", + "highest", + "family", + "counterparts", + "asr", "last", - "strength", + "thermal", + "contacts", "become", + "stability", + "proteins", + "use", + "ancestral", + "degree", + "enzymes", + "success", + "architecture", + "small", "found", - "determinants", + "since", + "higher", + "organisms", + "pathways", + "bacteria", + "intensive", + "increase", + "correlates", + "highlight", + "challenging", + "responsible", + "benefits", + "kinases", + "moreover", + "used", + "research", + "natural", + "functional", + "potential", + "tool", + "easily", + "usually", + "thermophilic", "explore", - "protein", - "given", + "amino", + "type", + "interaction", + "pathway", + "sequence", + "history", + "nonetheless", + "dynamics", + "evolutionary", "marginally", + "often", + "determinants", + "many", + "strategies", "dependent", - "gained", - "since", - "tool" + "main", + "identification", + "reconstruction", + "approaches", + "area", + "structure", + "temperature", + "crystallography", + "frequently", + "cases", + "making", + "identify", + "high", + "support", + "homology", + "trace", + "years", + "result", + "acids", + "environmental", + "vitamin", + "biophysics" ], "release_date":"2024-02-07", "publication":"\"Deciphering Structural Traits for Thermal and Kinetic Stability across Protein Family Evolution through Ancestral Sequence Reconstruction\", Mol.Biol.Evol., 41", @@ -671866,10 +674685,6 @@ "sim":190.0, "partner":"2i5b" }, - { - "sim":150.0, - "partner":"4c5l" - }, { "sim":150.0, "partner":"4c5m" @@ -671886,6 +674701,10 @@ "sim":150.0, "partner":"4c5k" }, + { + "sim":150.0, + "partner":"4c5l" + }, { "sim":142.0, "partner":"3rm5" @@ -671920,15 +674739,15 @@ }, { "sim":60.0, - "partner":"5zw9" + "partner":"5zwb" }, { "sim":60.0, - "partner":"5zwa" + "partner":"5zw9" }, { "sim":60.0, - "partner":"5zwb" + "partner":"5zwa" }, { "sim":58.0, @@ -671938,10 +674757,6 @@ "sim":58.0, "partner":"1vi9" }, - { - "sim":58.0, - "partner":"6yjz" - }, { "sim":58.0, "partner":"6yk0" @@ -671951,16 +674766,12 @@ "partner":"6yk1" }, { - "sim":57.0, - "partner":"1rfu" - }, - { - "sim":57.0, - "partner":"2yxt" + "sim":58.0, + "partner":"6yjz" }, { "sim":57.0, - "partner":"2yxu" + "partner":"1rfu" }, { "sim":57.0, @@ -672010,6 +674821,14 @@ "sim":57.0, "partner":"4en4" }, + { + "sim":57.0, + "partner":"2yxt" + }, + { + "sim":57.0, + "partner":"2yxu" + }, { "sim":57.0, "partner":"2ajp" @@ -672024,15 +674843,15 @@ }, { "sim":51.0, - "partner":"3ibq" + "partner":"3hyo" }, { "sim":51.0, - "partner":"3hyo" + "partner":"3h74" }, { "sim":51.0, - "partner":"3h74" + "partner":"3ibq" } ], "struct_thr_sim_designed":[ @@ -672206,11 +675025,11 @@ ], "subtitle":"Complex of tbrii mini protein binder bound to the tbrii ecd", "tags":[ + "mpb", "computationally designed mini protein binder", - "tgf-b type ii receptor", "tbrii", - "signaling protein", - "mpb" + "tgf-b type ii receptor", + "signaling protein" ], "keywords":[ "description", @@ -672265,7 +675084,7 @@ ], "struct_max_sim_designed":{ "sim":0.8241999745, - "partner":"8v3b" + "partner":"8vea" }, "struct_max_sim_natural":{ "sim":0.7088000178, @@ -672360,79 +675179,79 @@ ], "subtitle":"C3hr3_9r_shift4: extendable repeat protein fiber", "tags":[ - "oligomer", "de novo protein", - "repeat protein" + "repeat protein", + "oligomer" ], "keywords":[ - "axes", - "monomers", - "coiled", - "generating", - "architectures", - "demonstrate", - "considerable", - "staggering", - "oligomers", + "relatively", + "superhelical", + "c", + "fibres", + "flexibility", + "designed", + "surface", "molecular", - "coincident", - "proteins", - "shortened", - "placement", - "geometry", - "approach", - "extended", - "systematically", - "wide", + "symmetry", + "design", + "limited", + "protomers", + "introducing", + "patches", "length", - "fixed", - "extendable", - "among", - "designed", + "geometry", + "repeat", "number", - "modular", + "unbounded", + "tuned", + "fixed", "lengthened", - "changing", + "oligomers", + "systematically", + "constituent", + "coincident", + "monomers", + "extendable", + "extended", "rigid", - "flexibility", + "among", + "hydrophilic", "precisely", - "materials", - "symmetric", - "constituent", - "limited", - "systematic", - "blocks", - "tuned", - "propagation", - "design", - "units", - "helical", - "superhelical", + "cyclic", + "changing", "protein", - "8", - "2", - "protomers", - "coils", - "symmetry", - "describe", - "c", - "relatively", "readily", - "repeat", - "surface", - "patches", + "architectures", + "propagation", + "wide", + "approach", + "blocks", + "proteins", + "helical", + "symmetric", + "shortened", "force", + "systematic", "varying", - "hydrophilic", - "monomer", - "introducing", - "fibres", + "coiled", + "considerable", + "modular", + "2", + "units", + "demonstrate", + "advantages", "building", - "unbounded", "systems", - "advantages", - "cyclic", - "range" + "axes", + "generating", + "coils", + "describe", + "range", + "monomer", + "materials", + "placement", + "8", + "staggering" ], "release_date":"2023-08-30", "publication":"\"Precisely patterned nanofibres made from extendable protein multiplexes\", Nat.Chem., 15, 1664-1671", @@ -672649,112 +675468,112 @@ ], "subtitle":"Geometrically programmable nanomaterial construction using regularized protein building blocks", "tags":[ + "protein building blocks", + "de novo design", "nanomaterial", - "train-track", "de novo protein", - "protein building blocks", - "de novo design" + "train-track" ], "keywords":[ "largely", - "oligomers", - "many", + "regularity", + "specified", + "number", + "owing", + "well", + "nested", + "wooden", + "protein", + "readily", + "linear", + "electron", + "blueprinted", + "microscopy", + "straightforward", + "house", + "circular", + "multicomponent", + "standards", + "secondary", + "envelope", + "using", + "placement", + "geometric", + "construction", + "complex", + "enables", "conform", - "inherit", + "backbones", + "comparison", + "enabling", + "polygonal", + "surfaces", + "track", + "blocks", "modules", - "crystallography", - "extendable", - "designed", - "geometries", - "deliberate", - "curved", + "large", "shapes", - "envelope", - "irregular", - "geometric", + "deliberate", + "pieces", + "1", + "geometries", + "consists", "blueprints", - "interactions", - "validate", - "structure", - "owing", - "building", + "design", + "onto", "principles", - "backbones", - "interaction", - "extendability", - "enables", - "straightforward", - "house", - "linear", - "angled", - "number", - "simple", + "expanded", + "simplicity", "geometrical", - "wooden", - "concentrically", - "relationships", - "onto", - "structures", - "nanomaterial", - "complexity", - "pieces", - "polygonal", - "circular", - "unbounded", - "much", + "simple", + "possible", + "different", + "sizes", "platform", - "previously", + "straight", + "architectural", "nanocages", - "polyhedral", - "regularity", - "specified", - "large", - "nested", + "complexity", + "relationships", + "build", + "validate", + "extendability", + "lumber", + "interaction", + "varying", + "nanomaterials", + "building", + "describe", "assemblies", + "designed", + "reinforced", + "concentrically", + "contracted", + "nanomaterial", + "curved", + "many", + "unbounded", + "structures", "ranging", - "1", - "lumber", - "surfaces", + "reconfigurable", + "polyhedral", + "oligomers", + "previously", + "structure", + "extendable", + "frame", "according", - "straight", + "irregular", + "crystallography", + "interactions", + "angled", + "regular", "blank", - "blocks", - "comparison", - "design", + "much", "canvas", - "using", - "secondary", - "describe", - "nanomaterials", - "architectural", - "reinforced", - "enabling", - "multicomponent", + "struts", "designs", - "build", - "construction", - "track", - "placement", - "sizes", - "electron", - "well", - "different", - "contracted", - "protein", - "regular", - "microscopy", - "frame", - "standards", - "complex", - "reconfigurable", - "readily", - "blueprinted", - "varying", - "consists", - "simplicity", - "possible", - "expanded", - "struts" + "inherit" ], "release_date":"2024-03-13", "publication":"\"Blueprinting extendable nanomaterials with standardized protein blocks\", Nature, 627, 898-904", @@ -673003,112 +675822,112 @@ ], "subtitle":"Geometrically programmable nanomaterial construction using regularized protein building blocks", "tags":[ + "protein building blocks", + "de novo design", "nanomaterial", - "train-track", "de novo protein", - "protein building blocks", - "de novo design" + "train-track" ], "keywords":[ "largely", - "oligomers", - "many", + "regularity", + "specified", + "number", + "owing", + "well", + "nested", + "wooden", + "protein", + "readily", + "linear", + "electron", + "blueprinted", + "microscopy", + "straightforward", + "house", + "circular", + "multicomponent", + "standards", + "secondary", + "envelope", + "using", + "placement", + "geometric", + "construction", + "complex", + "enables", "conform", - "inherit", + "backbones", + "comparison", + "enabling", + "polygonal", + "surfaces", + "track", + "blocks", "modules", - "crystallography", - "extendable", - "designed", - "geometries", - "deliberate", - "curved", + "large", "shapes", - "envelope", - "irregular", - "geometric", + "deliberate", + "pieces", + "1", + "geometries", + "consists", "blueprints", - "interactions", - "validate", - "structure", - "owing", - "building", + "design", + "onto", "principles", - "backbones", - "interaction", - "extendability", - "enables", - "straightforward", - "house", - "linear", - "angled", - "number", - "simple", + "expanded", + "simplicity", "geometrical", - "wooden", - "concentrically", - "relationships", - "onto", - "structures", - "nanomaterial", - "complexity", - "pieces", - "polygonal", - "circular", - "unbounded", - "much", + "simple", + "possible", + "different", + "sizes", "platform", - "previously", + "straight", + "architectural", "nanocages", - "polyhedral", - "regularity", - "specified", - "large", - "nested", + "complexity", + "relationships", + "build", + "validate", + "extendability", + "lumber", + "interaction", + "varying", + "nanomaterials", + "building", + "describe", "assemblies", + "designed", + "reinforced", + "concentrically", + "contracted", + "nanomaterial", + "curved", + "many", + "unbounded", + "structures", "ranging", - "1", - "lumber", - "surfaces", + "reconfigurable", + "polyhedral", + "oligomers", + "previously", + "structure", + "extendable", + "frame", "according", - "straight", + "irregular", + "crystallography", + "interactions", + "angled", + "regular", "blank", - "blocks", - "comparison", - "design", + "much", "canvas", - "using", - "secondary", - "describe", - "nanomaterials", - "architectural", - "reinforced", - "enabling", - "multicomponent", + "struts", "designs", - "build", - "construction", - "track", - "placement", - "sizes", - "electron", - "well", - "different", - "contracted", - "protein", - "regular", - "microscopy", - "frame", - "standards", - "complex", - "reconfigurable", - "readily", - "blueprinted", - "varying", - "consists", - "simplicity", - "possible", - "expanded", - "struts" + "inherit" ], "release_date":"2024-03-13", "publication":"\"Blueprinting extendable nanomaterials with standardized protein blocks\", Nature, 627, 898-904", @@ -673337,112 +676156,112 @@ ], "subtitle":"Geometrically programmable nanomaterial construction using regularized protein building blocks", "tags":[ + "protein building blocks", + "de novo design", "nanomaterial", - "train-track", "de novo protein", - "protein building blocks", - "de novo design" + "train-track" ], "keywords":[ "largely", - "oligomers", - "many", + "regularity", + "specified", + "number", + "owing", + "well", + "nested", + "wooden", + "protein", + "readily", + "linear", + "electron", + "blueprinted", + "microscopy", + "straightforward", + "house", + "circular", + "multicomponent", + "standards", + "secondary", + "envelope", + "using", + "placement", + "geometric", + "construction", + "complex", + "enables", "conform", - "inherit", + "backbones", + "comparison", + "enabling", + "polygonal", + "surfaces", + "track", + "blocks", "modules", - "crystallography", - "extendable", - "designed", - "geometries", - "deliberate", - "curved", + "large", "shapes", - "envelope", - "irregular", - "geometric", + "deliberate", + "pieces", + "1", + "geometries", + "consists", "blueprints", - "interactions", - "validate", - "structure", - "owing", - "building", + "design", + "onto", "principles", - "backbones", - "interaction", - "extendability", - "enables", - "straightforward", - "house", - "linear", - "angled", - "number", - "simple", + "expanded", + "simplicity", "geometrical", - "wooden", - "concentrically", - "relationships", - "onto", - "structures", - "nanomaterial", - "complexity", - "pieces", - "polygonal", - "circular", - "unbounded", - "much", + "simple", + "possible", + "different", + "sizes", "platform", - "previously", + "straight", + "architectural", "nanocages", - "polyhedral", - "regularity", - "specified", - "large", - "nested", + "complexity", + "relationships", + "build", + "validate", + "extendability", + "lumber", + "interaction", + "varying", + "nanomaterials", + "building", + "describe", "assemblies", + "designed", + "reinforced", + "concentrically", + "contracted", + "nanomaterial", + "curved", + "many", + "unbounded", + "structures", "ranging", - "1", - "lumber", - "surfaces", + "reconfigurable", + "polyhedral", + "oligomers", + "previously", + "structure", + "extendable", + "frame", "according", - "straight", + "irregular", + "crystallography", + "interactions", + "angled", + "regular", "blank", - "blocks", - "comparison", - "design", + "much", "canvas", - "using", - "secondary", - "describe", - "nanomaterials", - "architectural", - "reinforced", - "enabling", - "multicomponent", + "struts", "designs", - "build", - "construction", - "track", - "placement", - "sizes", - "electron", - "well", - "different", - "contracted", - "protein", - "regular", - "microscopy", - "frame", - "standards", - "complex", - "reconfigurable", - "readily", - "blueprinted", - "varying", - "consists", - "simplicity", - "possible", - "expanded", - "struts" + "inherit" ], "release_date":"2024-03-13", "publication":"\"Blueprinting extendable nanomaterials with standardized protein blocks\", Nature, 627, 898-904", @@ -673656,112 +676475,112 @@ ], "subtitle":"Geometrically programmable nanomaterial construction using regularized protein building blocks", "tags":[ + "protein building blocks", + "de novo design", "nanomaterial", - "train-track", "de novo protein", - "protein building blocks", - "de novo design" + "train-track" ], "keywords":[ "largely", - "oligomers", - "many", + "regularity", + "specified", + "number", + "owing", + "well", + "nested", + "wooden", + "protein", + "readily", + "linear", + "electron", + "blueprinted", + "microscopy", + "straightforward", + "house", + "circular", + "multicomponent", + "standards", + "secondary", + "envelope", + "using", + "placement", + "geometric", + "construction", + "complex", + "enables", "conform", - "inherit", + "backbones", + "comparison", + "enabling", + "polygonal", + "surfaces", + "track", + "blocks", "modules", - "crystallography", - "extendable", - "designed", - "geometries", - "deliberate", - "curved", + "large", "shapes", - "envelope", - "irregular", - "geometric", + "deliberate", + "pieces", + "1", + "geometries", + "consists", "blueprints", - "interactions", - "validate", - "structure", - "owing", - "building", + "design", + "onto", "principles", - "backbones", - "interaction", - "extendability", - "enables", - "straightforward", - "house", - "linear", - "angled", - "number", - "simple", + "expanded", + "simplicity", "geometrical", - "wooden", - "concentrically", - "relationships", - "onto", - "structures", - "nanomaterial", - "complexity", - "pieces", - "polygonal", - "circular", - "unbounded", - "much", + "simple", + "possible", + "different", + "sizes", "platform", - "previously", + "straight", + "architectural", "nanocages", - "polyhedral", - "regularity", - "specified", - "large", - "nested", + "complexity", + "relationships", + "build", + "validate", + "extendability", + "lumber", + "interaction", + "varying", + "nanomaterials", + "building", + "describe", "assemblies", + "designed", + "reinforced", + "concentrically", + "contracted", + "nanomaterial", + "curved", + "many", + "unbounded", + "structures", "ranging", - "1", - "lumber", - "surfaces", + "reconfigurable", + "polyhedral", + "oligomers", + "previously", + "structure", + "extendable", + "frame", "according", - "straight", + "irregular", + "crystallography", + "interactions", + "angled", + "regular", "blank", - "blocks", - "comparison", - "design", + "much", "canvas", - "using", - "secondary", - "describe", - "nanomaterials", - "architectural", - "reinforced", - "enabling", - "multicomponent", + "struts", "designs", - "build", - "construction", - "track", - "placement", - "sizes", - "electron", - "well", - "different", - "contracted", - "protein", - "regular", - "microscopy", - "frame", - "standards", - "complex", - "reconfigurable", - "readily", - "blueprinted", - "varying", - "consists", - "simplicity", - "possible", - "expanded", - "struts" + "inherit" ], "release_date":"2024-03-13", "publication":"\"Blueprinting extendable nanomaterials with standardized protein blocks\", Nature, 627, 898-904", @@ -673910,79 +676729,79 @@ ], "subtitle":"C4hr1_4r: extendable repeat protein tetramer", "tags":[ - "oligomer", "de novo protein", - "repeat protein" + "repeat protein", + "oligomer" ], "keywords":[ - "axes", - "monomers", - "coiled", - "generating", - "architectures", - "demonstrate", - "considerable", - "staggering", - "oligomers", + "relatively", + "superhelical", + "c", + "fibres", + "flexibility", + "designed", + "surface", "molecular", - "coincident", - "proteins", - "shortened", - "placement", - "geometry", - "approach", - "extended", - "systematically", - "wide", + "symmetry", + "design", + "limited", + "protomers", + "introducing", + "patches", "length", - "fixed", - "extendable", - "among", - "designed", + "geometry", + "repeat", "number", - "modular", + "unbounded", + "tuned", + "fixed", "lengthened", - "changing", + "oligomers", + "systematically", + "constituent", + "coincident", + "monomers", + "extendable", + "extended", "rigid", - "flexibility", + "among", + "hydrophilic", "precisely", - "materials", - "symmetric", - "constituent", - "limited", - "systematic", - "blocks", - "tuned", - "propagation", - "design", - "units", - "helical", - "superhelical", + "cyclic", + "changing", "protein", - "8", - "2", - "protomers", - "coils", - "symmetry", - "describe", - "c", - "relatively", "readily", - "repeat", - "surface", - "patches", + "architectures", + "propagation", + "wide", + "approach", + "blocks", + "proteins", + "helical", + "symmetric", + "shortened", "force", + "systematic", "varying", - "hydrophilic", - "monomer", - "introducing", - "fibres", + "coiled", + "considerable", + "modular", + "2", + "units", + "demonstrate", + "advantages", "building", - "unbounded", "systems", - "advantages", - "cyclic", - "range" + "axes", + "generating", + "coils", + "describe", + "range", + "monomer", + "materials", + "placement", + "8", + "staggering" ], "release_date":"2023-08-30", "publication":"\"Precisely patterned nanofibres made from extendable protein multiplexes\", Nat.Chem., 15, 1664-1671", @@ -674131,79 +676950,79 @@ ], "subtitle":"C6hr1_4r: extendable repeat protein hexamer", "tags":[ - "oligomer", "de novo protein", - "repeat protein" + "repeat protein", + "oligomer" ], "keywords":[ - "axes", - "monomers", - "coiled", - "generating", - "architectures", - "demonstrate", - "considerable", - "staggering", - "oligomers", + "relatively", + "superhelical", + "c", + "fibres", + "flexibility", + "designed", + "surface", "molecular", - "coincident", - "proteins", - "shortened", - "placement", - "geometry", - "approach", - "extended", - "systematically", - "wide", + "symmetry", + "design", + "limited", + "protomers", + "introducing", + "patches", "length", - "fixed", - "extendable", - "among", - "designed", + "geometry", + "repeat", "number", - "modular", + "unbounded", + "tuned", + "fixed", "lengthened", - "changing", + "oligomers", + "systematically", + "constituent", + "coincident", + "monomers", + "extendable", + "extended", "rigid", - "flexibility", + "among", + "hydrophilic", "precisely", - "materials", - "symmetric", - "constituent", - "limited", - "systematic", - "blocks", - "tuned", - "propagation", - "design", - "units", - "helical", - "superhelical", + "cyclic", + "changing", "protein", - "8", - "2", - "protomers", - "coils", - "symmetry", - "describe", - "c", - "relatively", "readily", - "repeat", - "surface", - "patches", + "architectures", + "propagation", + "wide", + "approach", + "blocks", + "proteins", + "helical", + "symmetric", + "shortened", "force", + "systematic", "varying", - "hydrophilic", - "monomer", - "introducing", - "fibres", + "coiled", + "considerable", + "modular", + "2", + "units", + "demonstrate", + "advantages", "building", - "unbounded", "systems", - "advantages", - "cyclic", - "range" + "axes", + "generating", + "coils", + "describe", + "range", + "monomer", + "materials", + "placement", + "8", + "staggering" ], "release_date":"2023-08-30", "publication":"\"Precisely patterned nanofibres made from extendable protein multiplexes\", Nat.Chem., 15, 1664-1671", @@ -674413,76 +677232,76 @@ "subtitle":"Crystal structure of ctla-4 in complex with a high affinity ctla-4 binder", "tags":[ "high affinity binder", - "de novo protein design", - "de novo protein\/immune system", "immune system", + "de novo protein-immune system complex", + "de novo protein design", "ctla-4", - "de novo protein-immune system complex" + "de novo protein\/immune system" ], "keywords":[ - "sites", - "general", - "concave", - "geometrically", - "following", - "generating", - "minibinders", - "overall", - "primarily", - "proteins", + "affinity", + "designed", + "surface", + "complex", "models", - "receptors", "complementarity", - "approach", - "low", - "generate", + "design", + "miniproteins", + "receptors", + "binders", + "provides", + "minibinders", "de", - "novo", - "globular", + "used", "outstanding", - "potent", - "challenge", - "close", + "progress", + "due", + "experimental", + "computationally", + "structures", + "agreement", + "overall", + "biological", + "remains", + "residues", "route", "scaffolds", - "experimental", - "convex", - "optimization", + "level", "shape", - "designed", - "small", - "residues", - "remains", - "employ", - "used", - "affinities", - "binders", - "agreement", - "activity", - "due", + "primarily", "target", - "provides", - "picomolar", - "design", - "regions", - "nanomolar", - "bind", "protein", - "tgf\u03b2rii", - "structures", - "complex", - "progress", - "surface", - "describe", - "high", + "optimization", + "globular", + "bind", + "approach", + "sites", + "proteins", + "binding", + "low", + "following", + "close", "matching", - "biological", - "computationally", + "novo", + "general", + "activity", + "high", + "small", + "picomolar", + "geometrically", + "generating", + "potent", + "convex", + "describe", + "concave", + "challenge", + "employ", + "nanomolar", "computational", - "affinity", - "binding", - "level", - "miniproteins" + "affinities", + "regions", + "generate", + "tgf\u03b2rii" ], "release_date":"2024-08-21", "publication":"\"Design of High Affinity Binders to Convex Protein Target Sites\", Biorxiv", @@ -674683,75 +677502,75 @@ ], "subtitle":"Crystal structure of a high affinity ctla-4 binder", "tags":[ - "high affinity binder", "de novo protein design", "protein binding", + "high affinity binder", "ctla-4" ], "keywords":[ - "sites", - "general", - "concave", - "geometrically", - "following", - "generating", - "minibinders", - "overall", - "primarily", - "proteins", + "affinity", + "designed", + "surface", + "complex", "models", - "receptors", "complementarity", - "approach", - "low", - "generate", + "design", + "miniproteins", + "receptors", + "binders", + "provides", + "minibinders", "de", - "novo", - "globular", + "used", "outstanding", - "potent", - "challenge", - "close", + "progress", + "due", + "experimental", + "computationally", + "structures", + "agreement", + "overall", + "biological", + "remains", + "residues", "route", "scaffolds", - "experimental", - "convex", - "optimization", + "level", "shape", - "designed", - "small", - "residues", - "remains", - "employ", - "used", - "affinities", - "binders", - "agreement", - "activity", - "due", + "primarily", "target", - "provides", - "picomolar", - "design", - "regions", - "nanomolar", - "bind", "protein", - "tgf\u03b2rii", - "structures", - "complex", - "progress", - "surface", - "describe", - "high", + "optimization", + "globular", + "bind", + "approach", + "sites", + "proteins", + "binding", + "low", + "following", + "close", "matching", - "biological", - "computationally", + "novo", + "general", + "activity", + "high", + "small", + "picomolar", + "geometrically", + "generating", + "potent", + "convex", + "describe", + "concave", + "challenge", + "employ", + "nanomolar", "computational", - "affinity", - "binding", - "level", - "miniproteins" + "affinities", + "regions", + "generate", + "tgf\u03b2rii" ], "release_date":"2024-08-21", "publication":"\"Design of High Affinity Binders to Convex Protein Target Sites\", Biorxiv", @@ -674952,75 +677771,75 @@ ], "subtitle":"Crystal structure of a high affinity pd-l1 binder", "tags":[ - "high affinity binder", "de novo protein design", "protein binding", + "high affinity binder", "pd-l1" ], "keywords":[ - "sites", - "general", - "concave", - "geometrically", - "following", - "generating", - "minibinders", - "overall", - "primarily", - "proteins", + "affinity", + "designed", + "surface", + "complex", "models", - "receptors", "complementarity", - "approach", - "low", - "generate", + "design", + "miniproteins", + "receptors", + "binders", + "provides", + "minibinders", "de", - "novo", - "globular", + "used", "outstanding", - "potent", - "challenge", - "close", + "progress", + "due", + "experimental", + "computationally", + "structures", + "agreement", + "overall", + "biological", + "remains", + "residues", "route", "scaffolds", - "experimental", - "convex", - "optimization", + "level", "shape", - "designed", - "small", - "residues", - "remains", - "employ", - "used", - "affinities", - "binders", - "agreement", - "activity", - "due", + "primarily", "target", - "provides", - "picomolar", - "design", - "regions", - "nanomolar", - "bind", "protein", - "tgf\u03b2rii", - "structures", - "complex", - "progress", - "surface", - "describe", - "high", + "optimization", + "globular", + "bind", + "approach", + "sites", + "proteins", + "binding", + "low", + "following", + "close", "matching", - "biological", - "computationally", + "novo", + "general", + "activity", + "high", + "small", + "picomolar", + "geometrically", + "generating", + "potent", + "convex", + "describe", + "concave", + "challenge", + "employ", + "nanomolar", "computational", - "affinity", - "binding", - "level", - "miniproteins" + "affinities", + "regions", + "generate", + "tgf\u03b2rii" ], "release_date":"2024-08-21", "publication":"\"Design of High Affinity Binders to Convex Protein Target Sites\", Biorxiv", @@ -675165,79 +677984,79 @@ ], "subtitle":"C5hr2_4r: extendable repeat protein pentamer", "tags":[ - "oligomer", "de novo protein", - "repeat protein" + "repeat protein", + "oligomer" ], "keywords":[ - "axes", - "monomers", - "coiled", - "generating", - "architectures", - "demonstrate", - "considerable", - "staggering", - "oligomers", + "relatively", + "superhelical", + "c", + "fibres", + "flexibility", + "designed", + "surface", "molecular", - "coincident", - "proteins", - "shortened", - "placement", - "geometry", - "approach", - "extended", - "systematically", - "wide", + "symmetry", + "design", + "limited", + "protomers", + "introducing", + "patches", "length", - "fixed", - "extendable", - "among", - "designed", + "geometry", + "repeat", "number", - "modular", + "unbounded", + "tuned", + "fixed", "lengthened", - "changing", + "oligomers", + "systematically", + "constituent", + "coincident", + "monomers", + "extendable", + "extended", "rigid", - "flexibility", + "among", + "hydrophilic", "precisely", - "materials", - "symmetric", - "constituent", - "limited", - "systematic", - "blocks", - "tuned", - "propagation", - "design", - "units", - "helical", - "superhelical", + "cyclic", + "changing", "protein", - "8", - "2", - "protomers", - "coils", - "symmetry", - "describe", - "c", - "relatively", "readily", - "repeat", - "surface", - "patches", + "architectures", + "propagation", + "wide", + "approach", + "blocks", + "proteins", + "helical", + "symmetric", + "shortened", "force", + "systematic", "varying", - "hydrophilic", - "monomer", - "introducing", - "fibres", + "coiled", + "considerable", + "modular", + "2", + "units", + "demonstrate", + "advantages", "building", - "unbounded", "systems", - "advantages", - "cyclic", - "range" + "axes", + "generating", + "coils", + "describe", + "range", + "monomer", + "materials", + "placement", + "8", + "staggering" ], "release_date":"2023-08-30", "publication":"\"Precisely patterned nanofibres made from extendable protein multiplexes\", Nat.Chem., 15, 1664-1671", @@ -675364,97 +678183,97 @@ "de novo protein" ], "keywords":[ - "many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - "mild", - "number", - "materials", - "nature", - "furthermore", - "modularity", - "dynamics", - "positions", - "assembly", - "ease", - "though", + "characterized", + "metal", "nearly", + "reactions", + "interconversion", + "furthermore", + "exceptionally", + "enabled", "thiol", - "permutations", - "framework", - "accelerate", - "transformations", - "molecular", - "expected", "frameworks", - "conditions", - "assemblies", - "calculations", - "reactions", - "redox", - "active", - "landscape", - "synthesis", - "engineering", + "positive", + "sites", + "characterization", + "ions", "several", + "nitric", + "mild", + "including", + "supporting", + "peptide", + "undergo", + "permutations", + "redox", + "toxic", "design", - "functionality", - "characterization", - "cooperative", - "using", - "exceptionally", - "negative", "displayed", - "high", - "importantly", - "underlying", - "nitric", - "notably", - "hindered", - "ion", - "sites", "diverse", - "leveraging", - "delivery", - "noncovalent", - "undergo", - "observations", - "applicable", + "active", + "assembly", + "porous", + "rich", + "synthesis", + "selective", "also", - "rational", + "applicable", + "conditions", + "modularity", + "noncovalent", + "underlying", + "notably", + "oxide", + "versatile", + "reactive", + "landscape", + "unique", + "assemblies", + "materials", + "accelerate", + "cooperative", + "dynamics", "reveal", - "uptake", - "positive", - "selective", + "calculations", + "diffraction", + "many", + "importantly", + "structurally", + "rational", "synthesized", - "biocompatible", - "complex", + "determined", "thiols", - "readily", - "enabled", - "supporting" + "supports", + "interactions", + "ion", + "nature", + "find", + "transformations", + "uptake", + "high", + "negative", + "though", + "observations" ], "release_date":"2023-11-15", "publication":"\"Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks\", J.Am.Chem.Soc., 145, 19588-19600", @@ -675575,97 +678394,97 @@ "de novo protein" ], "keywords":[ - "many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - "mild", - "number", - "materials", - "nature", - "furthermore", - "modularity", - "dynamics", - "positions", - "assembly", - "ease", - "though", + "characterized", + "metal", "nearly", + "reactions", + "interconversion", + "furthermore", + "exceptionally", + "enabled", "thiol", - "permutations", - "framework", - "accelerate", - "transformations", - "molecular", - "expected", "frameworks", - "conditions", - "assemblies", - "calculations", - 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"many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - "mild", - "number", - "materials", - "nature", - "furthermore", - "modularity", - "dynamics", - "positions", - "assembly", - "ease", - "though", + "characterized", + "metal", "nearly", + "reactions", + "interconversion", + "furthermore", + "exceptionally", + "enabled", "thiol", - "permutations", - "framework", - "accelerate", - "transformations", - "molecular", - "expected", "frameworks", - "conditions", - "assemblies", - "calculations", - 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"biocompatible", - "complex", + "determined", "thiols", - "readily", - "enabled", - "supporting" + "supports", + "interactions", + "ion", + "nature", + "find", + "transformations", + "uptake", + "high", + "negative", + "though", + "observations" ], "release_date":"2023-11-15", "publication":"\"Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks\", J.Am.Chem.Soc., 145, 19588-19600", @@ -676212,97 +679031,97 @@ "de novo protein" ], "keywords":[ - "many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - 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"many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - "mild", - "number", - "materials", - "nature", - "furthermore", - "modularity", - "dynamics", - "positions", - "assembly", - "ease", - "though", + "characterized", + "metal", "nearly", + "reactions", + "interconversion", + "furthermore", + "exceptionally", + "enabled", "thiol", - "permutations", - "framework", - "accelerate", - "transformations", - "molecular", - "expected", "frameworks", - "conditions", - "assemblies", - "calculations", - 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"biocompatible", - "complex", + "determined", "thiols", - "readily", - "enabled", - "supporting" + "supports", + "interactions", + "ion", + "nature", + "find", + "transformations", + "uptake", + "high", + "negative", + "though", + "observations" ], "release_date":"2023-11-15", "publication":"\"Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks\", J.Am.Chem.Soc., 145, 19588-19600", @@ -676634,97 +679453,97 @@ "de novo protein" ], "keywords":[ - "many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - 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"undergo", - "observations", - "applicable", + "active", + "assembly", + "porous", + "rich", + "synthesis", + "selective", "also", - "rational", + "applicable", + "conditions", + "modularity", + "noncovalent", + "underlying", + "notably", + "oxide", + "versatile", + "reactive", + "landscape", + "unique", + "assemblies", + "materials", + "accelerate", + "cooperative", + "dynamics", "reveal", - "uptake", - "positive", - "selective", + "calculations", + "diffraction", + "many", + "importantly", + "structurally", + "rational", "synthesized", - "biocompatible", - "complex", + "determined", "thiols", - "readily", - "enabled", - "supporting" + "supports", + "interactions", + "ion", + "nature", + "find", + "transformations", + "uptake", + "high", + "negative", + "though", + "observations" ], "release_date":"2023-11-15", "publication":"\"Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks\", J.Am.Chem.Soc., 145, 19588-19600", @@ -676845,97 +679664,97 @@ "de novo protein" ], "keywords":[ - "many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - "mild", - "number", - "materials", - "nature", - "furthermore", - "modularity", - "dynamics", - "positions", - "assembly", - "ease", - "though", + "characterized", + "metal", "nearly", + "reactions", + "interconversion", + "furthermore", + "exceptionally", + "enabled", "thiol", - "permutations", - "framework", - "accelerate", - "transformations", - "molecular", - "expected", "frameworks", - "conditions", - "assemblies", - "calculations", - 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"biocompatible", - "complex", + "determined", "thiols", - "readily", - "enabled", - "supporting" + "supports", + "interactions", + "ion", + "nature", + "find", + "transformations", + "uptake", + "high", + "negative", + "though", + "observations" ], "release_date":"2023-11-15", "publication":"\"Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks\", J.Am.Chem.Soc., 145, 19588-19600", @@ -677150,111 +679969,111 @@ ], "subtitle":"Cryo-em structure of synthetic tetrameric building block sc4", "tags":[ - "self-assembling", "de novo protein", + "self-assembling", "synthetic", "tetramer" ], "keywords":[ "largely", - "oligomers", - "many", + "regularity", + "specified", + "number", + "owing", + "well", + "nested", + "wooden", + "protein", + "readily", + "linear", + "electron", + "blueprinted", + "microscopy", + "straightforward", + "house", + "circular", + "multicomponent", + "standards", + "secondary", + "envelope", + "using", + "placement", + "geometric", + "construction", + "complex", + "enables", "conform", - "inherit", + "backbones", + "comparison", + "enabling", + "polygonal", + "surfaces", + "track", + "blocks", "modules", - "crystallography", - "extendable", - "designed", - "geometries", - "deliberate", - "curved", + "large", "shapes", - "envelope", - "irregular", - "geometric", + "deliberate", + "pieces", + "1", + "geometries", + "consists", "blueprints", - "interactions", - "validate", - "structure", - "owing", - "building", + "design", + "onto", "principles", - "backbones", - "interaction", - "extendability", - "enables", - "straightforward", - "house", - "linear", - "angled", - "number", - "simple", + "expanded", + "simplicity", "geometrical", - "wooden", - "concentrically", - "relationships", - "onto", - "structures", - "nanomaterial", - "complexity", - "pieces", - "polygonal", - "circular", - "unbounded", - "much", + "simple", + "possible", + "different", + "sizes", "platform", - "previously", + "straight", + "architectural", "nanocages", - "polyhedral", - "regularity", - "specified", - "large", - "nested", + "complexity", + "relationships", + "build", + "validate", + "extendability", + "lumber", + "interaction", + "varying", + "nanomaterials", + "building", + "describe", "assemblies", + "designed", + "reinforced", + "concentrically", + "contracted", + "nanomaterial", + "curved", + "many", + "unbounded", + "structures", "ranging", - "1", - "lumber", - "surfaces", + "reconfigurable", + "polyhedral", + "oligomers", + "previously", + "structure", + "extendable", + "frame", "according", - "straight", + "irregular", + "crystallography", + "interactions", + "angled", + "regular", "blank", - "blocks", - "comparison", - "design", + "much", "canvas", - "using", - "secondary", - "describe", - "nanomaterials", - "architectural", - "reinforced", - "enabling", - "multicomponent", + "struts", "designs", - "build", - "construction", - "track", - "placement", - "sizes", - "electron", - "well", - "different", - "contracted", - "protein", - "regular", - "microscopy", - "frame", - "standards", - "complex", - "reconfigurable", - "readily", - "blueprinted", - "varying", - "consists", - "simplicity", - "possible", - "expanded", - "struts" + "inherit" ], "release_date":"2024-03-13", "publication":"\"Blueprinting extendable nanomaterials with standardized protein blocks\", Nature, 627, 898-904", @@ -677379,97 +680198,97 @@ "de novo protein" ], "keywords":[ - "many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - "mild", - "number", - "materials", - "nature", - "furthermore", - "modularity", - "dynamics", - "positions", - "assembly", - "ease", - "though", + "characterized", + "metal", "nearly", + "reactions", + "interconversion", + "furthermore", + "exceptionally", + "enabled", "thiol", - "permutations", - "framework", - "accelerate", - "transformations", - "molecular", - "expected", "frameworks", - "conditions", - "assemblies", - "calculations", - "reactions", - "redox", - "active", - "landscape", - "synthesis", - "engineering", + "positive", + "sites", + "characterization", + "ions", "several", + "nitric", + "mild", + "including", + "supporting", + "peptide", + "undergo", + "permutations", + "redox", + "toxic", "design", - "functionality", - "characterization", - "cooperative", - "using", - "exceptionally", - "negative", "displayed", - "high", - "importantly", - "underlying", - "nitric", - "notably", - "hindered", - "ion", - "sites", "diverse", - "leveraging", - "delivery", - "noncovalent", - "undergo", - "observations", - "applicable", + "active", + "assembly", + "porous", + "rich", + "synthesis", + "selective", "also", - "rational", + "applicable", + "conditions", + "modularity", + "noncovalent", + "underlying", + "notably", + "oxide", + "versatile", + "reactive", + "landscape", + "unique", + "assemblies", + "materials", + "accelerate", + "cooperative", + "dynamics", "reveal", - "uptake", - "positive", - "selective", + "calculations", + "diffraction", + "many", + "importantly", + "structurally", + "rational", "synthesized", - "biocompatible", - "complex", + "determined", "thiols", - "readily", - "enabled", - "supporting" + "supports", + "interactions", + "ion", + "nature", + "find", + "transformations", + "uptake", + "high", + "negative", + "though", + "observations" ], "release_date":"2023-11-15", "publication":"\"Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks\", J.Am.Chem.Soc., 145, 19588-19600", @@ -677590,97 +680409,97 @@ "de novo protein" ], "keywords":[ - "many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - "mild", - "number", - "materials", - "nature", - "furthermore", - "modularity", - "dynamics", - "positions", - "assembly", - "ease", - "though", + "characterized", + "metal", "nearly", + "reactions", + "interconversion", + "furthermore", + "exceptionally", + "enabled", "thiol", - "permutations", - "framework", - "accelerate", - "transformations", - "molecular", - "expected", "frameworks", - "conditions", - "assemblies", - "calculations", - "reactions", - "redox", - "active", - "landscape", - "synthesis", - "engineering", + "positive", + "sites", + "characterization", + "ions", "several", + "nitric", + "mild", + "including", + "supporting", + "peptide", + "undergo", + "permutations", + "redox", + "toxic", "design", - "functionality", - "characterization", - "cooperative", - "using", - "exceptionally", - "negative", "displayed", - "high", - "importantly", - "underlying", - "nitric", - "notably", - "hindered", - "ion", - "sites", "diverse", - "leveraging", - "delivery", - "noncovalent", - "undergo", - "observations", - "applicable", + "active", + "assembly", + "porous", + "rich", + "synthesis", + "selective", "also", - "rational", + "applicable", + "conditions", + "modularity", + "noncovalent", + "underlying", + "notably", + "oxide", + "versatile", + "reactive", + "landscape", + "unique", + "assemblies", + "materials", + "accelerate", + "cooperative", + "dynamics", "reveal", - "uptake", - "positive", - "selective", + "calculations", + "diffraction", + "many", + "importantly", + "structurally", + "rational", "synthesized", - "biocompatible", - "complex", + "determined", "thiols", - "readily", - "enabled", - "supporting" + "supports", + "interactions", + "ion", + "nature", + "find", + "transformations", + "uptake", + "high", + "negative", + "though", + "observations" ], "release_date":"2023-11-15", "publication":"\"Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks\", J.Am.Chem.Soc., 145, 19588-19600", @@ -677783,83 +680602,83 @@ "subtitle":"X-ray crystallographic structure of a beta-hairpin peptide derived from abeta 17-35. (orn)lvffaed(orn)gai(n-me-ile)glm", "tags":[ "tetramer", - "oligomer", - "amyloid", "de novo protein", - "alzheimer's disease" + "oligomer", + "alzheimer's disease", + "amyloid" ], "keywords":[ - "differ", + "a\u03b2", + "designed", + "form", "facial", - "plays", - "demonstrate", - "tetrameric", + "ladder", + "disease", + "alignments", + "hairpins", + "adopt", "poorly", - "oligomers", - "chains", + "role", "many", - "arrangement", - "studied", - "a\u03b2", - "respectively", - "difference", - "similar", - "suggest", - "composition", + "assembles", "heterogeneous", - "oligomerization", - "source", - "altering", - "crystallography", - "heterogeneity", - "alignments", - "peptides", - "designed", - "trimers", - "alignment", - "different", - "residues", - "triangular", - "understood", + "behavior", + "observed", + "implicated", + "respectively", "dimer", + "oligomers", + "different", + "side", "alzheimer", - "two", - "implicated", + "effect", + "ad", + "hairpin", + "differences", + "residues", + "studied", + "mimic", + "leads", "hexamers", - "behavior", - "crystal", - "arrangements", - "state", - "assemble", - "observed", - "explore", + "trimers", "model", - "mimic", - "adopt", - "effect", + "explore", + "crystallography", "a\u03b2m", - "variety", - "differences", - "assembles", - "hairpins", - "either", - "hairpin", - "distinct", + "state", + "oligomerization", + "plays", + "source", "formation", - "form", - "leads", - "building", - "side", "oligomer", - "role", - "ladder", - "ad", - "disease", - "conformations", - "pathogenesis", + "understood", + "tetrameric", + "demonstrate", + "difference", + "building", + "arrangement", + "distinct", + "suggest", "forms", + "peptides", "contain", - "consist" + "conformations", + "two", + "variety", + "composition", + "altering", + "crystal", + "triangular", + "arrangements", + "chains", + "consist", + "heterogeneity", + "assemble", + "alignment", + "pathogenesis", + "similar", + "either", + "differ" ], "release_date":"2024-01-17", "publication":"\"beta-Hairpin Alignment Alters Oligomer Formation in A beta-Derived Peptides\", Biochemistry, 63, 212-218", @@ -677971,83 +680790,83 @@ "subtitle":"X-ray crystallographic structure of a beta-hairpin peptide derived from abeta 17-36. (orn)lvffaed(orn)aii(n-me-gly)lmv", "tags":[ "trimer", - "oligomer", - "amyloid", "de novo protein", - "alzheimer's disease" + "oligomer", + "alzheimer's disease", + "amyloid" ], "keywords":[ - "differ", + "a\u03b2", + "designed", + "form", "facial", - "plays", - "demonstrate", - "tetrameric", + "ladder", + "disease", + "alignments", + "hairpins", + "adopt", "poorly", - "oligomers", - "chains", + "role", "many", - "arrangement", - "studied", - "a\u03b2", - "respectively", - "difference", - "similar", - "suggest", - "composition", + "assembles", "heterogeneous", - "oligomerization", - "source", - "altering", - "crystallography", - "heterogeneity", - "alignments", - "peptides", - "designed", - "trimers", - "alignment", - "different", - "residues", - "triangular", - "understood", + "behavior", + "observed", + "implicated", + "respectively", "dimer", + "oligomers", + "different", + "side", "alzheimer", - "two", - "implicated", + "effect", + "ad", + "hairpin", + "differences", + "residues", + "studied", + "mimic", + "leads", "hexamers", - "behavior", - "crystal", - "arrangements", - "state", - "assemble", - "observed", - "explore", + "trimers", "model", - "mimic", - "adopt", - "effect", + "explore", + "crystallography", "a\u03b2m", - "variety", - "differences", - "assembles", - "hairpins", - "either", - "hairpin", - "distinct", + "state", + "oligomerization", + "plays", + "source", "formation", - "form", - "leads", - "building", - "side", "oligomer", - "role", - "ladder", - "ad", - "disease", - "conformations", - "pathogenesis", + "understood", + "tetrameric", + "demonstrate", + "difference", + "building", + "arrangement", + "distinct", + "suggest", "forms", + "peptides", "contain", - "consist" + "conformations", + "two", + "variety", + "composition", + "altering", + "crystal", + "triangular", + "arrangements", + "chains", + "consist", + "heterogeneity", + "assemble", + "alignment", + "pathogenesis", + "similar", + "either", + "differ" ], "release_date":"2024-01-17", "publication":"\"beta-Hairpin Alignment Alters Oligomer Formation in A beta-Derived Peptides\", Biochemistry, 63, 212-218", @@ -678259,99 +681078,99 @@ ], "subtitle":"De novo design of high-affinity protein binders to bioactive helical peptides", "tags":[ - "deep learning", + "alpha-helical peptides", "de novo protein", - "protein design", "diffusion", - "alpha-helical peptides" + "deep learning", + "protein design" ], "keywords":[ - "many", - "propensity", - "distributions", - "clinical", - "parametric", - "specificity", - "challenge", - "peptide", - "designed", - "sensitive", - "generated", - "hormone", - "variable", - "methods", - "show", - "interactions", - "8", - "successive", - "designing", - "structure", - "optimize", - "conformationally", - "denoising", - "broadly", - "however", "affinity", - "starting", "disease", - "enrichment", - "without", + "show", + "methods", + "experimental", + "biosensors", + "short", + "protein", + "mass", "5", - "structured", + "helical", + "binding", "refining", - "proteins", - "models", + "novo", + "subsequent", + "parametric", + "either", + "deep", + "construction", + "however", + "specificity", + "distributions", + "starting", + "targets", + "input", + "address", + "optimization", + "useful", "rfdiffusion", - "receptors", - "random", - "de", + "completely", + "propensity", + "proteins", "binder", + "parathyroid", + "enrichment", + "unmet", + "peptide", "detection", - "short", - "management", + "variable", + "glucagon", + "designing", + "design", "binders", - "ability", - "better", "natural", - "either", + "clinical", + "successive", + "hormones", + "ability", + "broadly", + "peptides", + "describe", + "noising", + "could", + "optimize", + "extending", "form", - "contribute", + "designed", + "models", "generation", - "noising", - "subsequent", + "many", + "receptors", + "de", + "contribute", + "conformationally", + "partial", + "structured", + "without", + "structure", "generate", - "optimization", - "address", - "useful", - "design", - "biosensors", - "helical", + "flexible", + "interactions", + "hormone", + "random", + "enable", + "management", + "high", + "generated", "noise", + "denoising", "diffusion", - "describe", - "high", - "could", - "input", - "completely", + "challenge", "designs", - "glucagon", - "construction", - "novo", - "flexible", - "experimental", - "peptides", - "parathyroid", - "enable", - "partial", - "protein", "spectrometry", - "targets", - "unmet", - "mass", - "hormones", - "extending", - "deep", - "binding" + "better", + "8", + "sensitive" ], "release_date":"2024-01-10", "publication":"\"De novo design of high-affinity binders of bioactive helical peptides\", Nature, 626, 435-442", @@ -678390,67 +681209,67 @@ "seq_thr_sim_natural":[ { "sim":56.0, - "partner":"6lml" + "partner":"6phm" }, { "sim":56.0, - "partner":"6phi" + "partner":"6phn" }, { "sim":56.0, - "partner":"6phj" + "partner":"6pho" }, { "sim":56.0, - "partner":"6phk" + "partner":"7xm8" }, { "sim":56.0, - "partner":"6phl" + "partner":"6nzn" }, { "sim":56.0, - "partner":"6phm" + "partner":"8jrv" }, { "sim":56.0, - "partner":"6phn" + "partner":"1kx6" }, { "sim":56.0, - "partner":"6pho" + "partner":"1gcn" }, { "sim":56.0, - "partner":"7xm8" + "partner":"2g49" }, { "sim":56.0, - "partner":"6nzn" + "partner":"6lmk" }, { "sim":56.0, - "partner":"1gcn" + "partner":"6eds" }, { "sim":56.0, - "partner":"1kx6" + "partner":"6lml" }, { "sim":56.0, - "partner":"2g49" + "partner":"6phi" }, { "sim":56.0, - "partner":"8jrv" + "partner":"6phj" }, { "sim":56.0, - "partner":"6lmk" + "partner":"6phk" }, { "sim":56.0, - "partner":"6eds" + "partner":"6phl" }, { "sim":56.0, @@ -678497,7 +681316,7 @@ }, "seq_max_sim_natural":{ "sim":56.0, - "partner":"6lml" + "partner":"6phm" }, "struct_max_sim_designed":{ "sim":0.7585999966, @@ -678664,99 +681483,99 @@ ], "subtitle":"De novo design of high-affinity protein binders to bioactive helical peptides", "tags":[ - "deep learning", + "alpha-helical peptides", "de novo protein", - "protein design", "diffusion", - "alpha-helical peptides" + "deep learning", + "protein design" ], "keywords":[ - "many", - "propensity", - "distributions", - "clinical", - "parametric", - "specificity", - "challenge", - "peptide", - "designed", - "sensitive", - "generated", - "hormone", - "variable", - "methods", - "show", - "interactions", - "8", - "successive", - "designing", - "structure", - "optimize", - "conformationally", - "denoising", - "broadly", - "however", "affinity", - "starting", "disease", - "enrichment", - "without", + "show", + "methods", + "experimental", + "biosensors", + "short", + "protein", + "mass", "5", - "structured", + "helical", + "binding", "refining", - "proteins", - "models", + "novo", + "subsequent", + "parametric", + "either", + "deep", + "construction", + "however", + "specificity", + "distributions", + "starting", + "targets", + "input", + "address", + "optimization", + "useful", "rfdiffusion", - "receptors", - "random", - "de", + "completely", + "propensity", + "proteins", "binder", + "parathyroid", + "enrichment", + "unmet", + "peptide", "detection", - "short", - "management", + "variable", + "glucagon", + "designing", + "design", "binders", - "ability", - "better", "natural", - "either", + "clinical", + "successive", + "hormones", + "ability", + "broadly", + "peptides", + "describe", + "noising", + "could", + "optimize", + "extending", "form", - "contribute", + "designed", + "models", "generation", - "noising", - "subsequent", + "many", + "receptors", + "de", + "contribute", + "conformationally", + "partial", + "structured", + "without", + "structure", "generate", - "optimization", - "address", - "useful", - "design", - "biosensors", - "helical", + "flexible", + "interactions", + "hormone", + "random", + "enable", + "management", + "high", + "generated", "noise", + "denoising", "diffusion", - "describe", - "high", - "could", - "input", - "completely", + "challenge", "designs", - "glucagon", - "construction", - "novo", - "flexible", - "experimental", - "peptides", - "parathyroid", - "enable", - "partial", - "protein", "spectrometry", - "targets", - "unmet", - "mass", - "hormones", - "extending", - "deep", - "binding" + "better", + "8", + "sensitive" ], "release_date":"2024-01-10", "publication":"\"De novo design of high-affinity binders of bioactive helical peptides\", Nature, 626, 435-442", @@ -678795,63 +681614,63 @@ "seq_thr_sim_natural":[ { "sim":67.0, - "partner":"6lml" + "partner":"6phm" }, { "sim":67.0, - "partner":"6phi" + "partner":"6phn" }, { "sim":67.0, - "partner":"6phj" + "partner":"7xm8" }, { "sim":67.0, - "partner":"6phk" + "partner":"6nzn" }, { "sim":67.0, - "partner":"6phl" + "partner":"8jrv" }, { "sim":67.0, - "partner":"6phm" + "partner":"1kx6" }, { "sim":67.0, - "partner":"6phn" + "partner":"1gcn" }, { "sim":67.0, - "partner":"7xm8" + "partner":"2g49" }, { "sim":67.0, - "partner":"6nzn" + "partner":"6lmk" }, { "sim":67.0, - "partner":"1gcn" + "partner":"6eds" }, { "sim":67.0, - "partner":"1kx6" + "partner":"6lml" }, { "sim":67.0, - "partner":"2g49" + "partner":"6phi" }, { "sim":67.0, - "partner":"8jrv" + "partner":"6phj" }, { "sim":67.0, - "partner":"6lmk" + "partner":"6phk" }, { "sim":67.0, - "partner":"6eds" + "partner":"6phl" }, { "sim":66.0, @@ -678863,11 +681682,11 @@ }, { "sim":62.0, - "partner":"1bh0" + "partner":"6php" }, { "sim":62.0, - "partner":"6php" + "partner":"1bh0" }, { "sim":61.0, @@ -678879,11 +681698,11 @@ }, { "sim":60.0, - "partner":"8fu6" + "partner":"6wpw" }, { "sim":60.0, - "partner":"6wpw" + "partner":"8fu6" }, { "sim":59.0, @@ -678895,15 +681714,15 @@ }, { "sim":55.0, - "partner":"8jiq" + "partner":"8jis" }, { "sim":55.0, - "partner":"8jis" + "partner":"6whc" }, { "sim":55.0, - "partner":"6whc" + "partner":"8jiq" }, { "sim":54.0, @@ -678915,11 +681734,11 @@ }, { "sim":54.0, - "partner":"7vbh" + "partner":"7fin" }, { "sim":54.0, - "partner":"7fin" + "partner":"7vbh" }, { "sim":51.0, @@ -678938,7 +681757,7 @@ }, "seq_max_sim_natural":{ "sim":67.0, - "partner":"6lml" + "partner":"6phm" }, "struct_max_sim_designed":{ "sim":0.8022000194, @@ -679015,97 +681834,97 @@ "de novo protein" ], "keywords":[ - "many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - "mild", - "number", - "materials", - "nature", - "furthermore", - "modularity", - "dynamics", - "positions", - "assembly", - "ease", - "though", + "characterized", + "metal", "nearly", + "reactions", + "interconversion", + "furthermore", + "exceptionally", + "enabled", "thiol", - "permutations", - "framework", - "accelerate", - "transformations", - "molecular", - "expected", "frameworks", - "conditions", - "assemblies", - "calculations", - "reactions", - "redox", - "active", - "landscape", - "synthesis", - "engineering", + "positive", + "sites", + "characterization", + "ions", "several", + "nitric", + "mild", + "including", + "supporting", + "peptide", + "undergo", + "permutations", + "redox", + "toxic", "design", - "functionality", - "characterization", - "cooperative", - "using", - "exceptionally", - "negative", "displayed", - "high", - "importantly", - "underlying", - "nitric", - "notably", - "hindered", - "ion", - "sites", "diverse", - "leveraging", - "delivery", - "noncovalent", - "undergo", - "observations", - "applicable", + "active", + "assembly", + "porous", + "rich", + "synthesis", + "selective", "also", - "rational", + "applicable", + "conditions", + "modularity", + "noncovalent", + "underlying", + "notably", + "oxide", + "versatile", + "reactive", + "landscape", + "unique", + "assemblies", + "materials", + "accelerate", + "cooperative", + "dynamics", "reveal", - "uptake", - "positive", - "selective", + "calculations", + "diffraction", + "many", + "importantly", + "structurally", + "rational", "synthesized", - "biocompatible", - "complex", + "determined", "thiols", - "readily", - "enabled", - "supporting" + "supports", + "interactions", + "ion", + "nature", + "find", + "transformations", + "uptake", + "high", + "negative", + "though", + "observations" ], "release_date":"2023-11-15", "publication":"\"Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks\", J.Am.Chem.Soc., 145, 19588-19600", @@ -679226,97 +682045,97 @@ "de novo protein" ], "keywords":[ - "many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - "mild", - "number", - "materials", - "nature", - "furthermore", - "modularity", - "dynamics", - "positions", - "assembly", - "ease", - "though", + "characterized", + "metal", "nearly", + "reactions", + "interconversion", + "furthermore", + "exceptionally", + "enabled", "thiol", - "permutations", - "framework", - "accelerate", - "transformations", - "molecular", - "expected", "frameworks", - "conditions", - "assemblies", - "calculations", - 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"biocompatible", - "complex", + "determined", "thiols", - "readily", - "enabled", - "supporting" + "supports", + "interactions", + "ion", + "nature", + "find", + "transformations", + "uptake", + "high", + "negative", + "though", + "observations" ], "release_date":"2023-11-15", "publication":"\"Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks\", J.Am.Chem.Soc., 145, 19588-19600", @@ -679441,97 +682260,97 @@ "de novo protein" ], "keywords":[ - "many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - 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"undergo", - "observations", - "applicable", + "active", + "assembly", + "porous", + "rich", + "synthesis", + "selective", "also", - "rational", + "applicable", + "conditions", + "modularity", + "noncovalent", + "underlying", + "notably", + "oxide", + "versatile", + "reactive", + "landscape", + "unique", + "assemblies", + "materials", + "accelerate", + "cooperative", + "dynamics", "reveal", - "uptake", - "positive", - "selective", + "calculations", + "diffraction", + "many", + "importantly", + "structurally", + "rational", "synthesized", - "biocompatible", - "complex", + "determined", "thiols", - "readily", - "enabled", - "supporting" + "supports", + "interactions", + "ion", + "nature", + "find", + "transformations", + "uptake", + "high", + "negative", + "though", + "observations" ], "release_date":"2023-11-15", "publication":"\"Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks\", J.Am.Chem.Soc., 145, 19588-19600", @@ -679653,97 +682472,97 @@ "de novo protein" ], "keywords":[ - "many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - "mild", - "number", - "materials", - "nature", - "furthermore", - "modularity", - "dynamics", - "positions", - "assembly", - "ease", - "though", + "characterized", + "metal", "nearly", + "reactions", + "interconversion", + "furthermore", + "exceptionally", + "enabled", "thiol", - "permutations", - "framework", - "accelerate", - "transformations", - "molecular", - "expected", "frameworks", - "conditions", - "assemblies", - "calculations", - "reactions", - "redox", - "active", - "landscape", - "synthesis", - "engineering", + "positive", + "sites", + "characterization", + "ions", "several", + "nitric", + "mild", + "including", + "supporting", + "peptide", + "undergo", + "permutations", + "redox", + "toxic", "design", - "functionality", - "characterization", - "cooperative", - "using", - "exceptionally", - "negative", "displayed", - "high", - "importantly", - "underlying", - "nitric", - "notably", - "hindered", - "ion", - "sites", "diverse", - "leveraging", - "delivery", - "noncovalent", - "undergo", - "observations", - "applicable", + "active", + "assembly", + "porous", + "rich", + "synthesis", + "selective", "also", - "rational", + "applicable", + "conditions", + "modularity", + "noncovalent", + "underlying", + "notably", + "oxide", + "versatile", + "reactive", + "landscape", + "unique", + "assemblies", + "materials", + "accelerate", + "cooperative", + "dynamics", "reveal", - "uptake", - "positive", - "selective", + "calculations", + "diffraction", + "many", + "importantly", + "structurally", + "rational", "synthesized", - "biocompatible", - "complex", + "determined", "thiols", - "readily", - "enabled", - "supporting" + "supports", + "interactions", + "ion", + "nature", + "find", + "transformations", + "uptake", + "high", + "negative", + "though", + "observations" ], "release_date":"2023-11-15", "publication":"\"Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks\", J.Am.Chem.Soc., 145, 19588-19600", @@ -679864,97 +682683,97 @@ "de novo protein" ], "keywords":[ - "many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - "mild", - "number", - "materials", - "nature", - "furthermore", - "modularity", - "dynamics", - "positions", - "assembly", - "ease", - "though", + "characterized", + "metal", "nearly", + "reactions", + "interconversion", + "furthermore", + "exceptionally", + "enabled", "thiol", - "permutations", - "framework", - "accelerate", - "transformations", - "molecular", - "expected", "frameworks", - "conditions", - "assemblies", - "calculations", - "reactions", - "redox", - "active", - "landscape", - "synthesis", - "engineering", + "positive", + "sites", + "characterization", + "ions", "several", + "nitric", + "mild", + "including", + "supporting", + "peptide", + "undergo", + "permutations", + "redox", + "toxic", "design", - "functionality", - "characterization", - "cooperative", - "using", - "exceptionally", - "negative", "displayed", - "high", - "importantly", - "underlying", - "nitric", - "notably", - "hindered", - "ion", - "sites", "diverse", - "leveraging", - "delivery", - "noncovalent", - "undergo", - "observations", - "applicable", + "active", + "assembly", + "porous", + "rich", + "synthesis", + "selective", "also", - "rational", + "applicable", + "conditions", + "modularity", + "noncovalent", + "underlying", + "notably", + "oxide", + "versatile", + "reactive", + "landscape", + "unique", + "assemblies", + "materials", + "accelerate", + "cooperative", + "dynamics", "reveal", - "uptake", - "positive", - "selective", + "calculations", + "diffraction", + "many", + "importantly", + "structurally", + "rational", "synthesized", - "biocompatible", - "complex", + "determined", "thiols", - "readily", - "enabled", - "supporting" + "supports", + "interactions", + "ion", + "nature", + "find", + "transformations", + "uptake", + "high", + "negative", + "though", + "observations" ], "release_date":"2023-11-15", "publication":"\"Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks\", J.Am.Chem.Soc., 145, 19588-19600", @@ -680076,97 +682895,97 @@ "de novo protein" ], "keywords":[ - "many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - "mild", - "number", - "materials", - "nature", - "furthermore", - "modularity", - "dynamics", - "positions", - "assembly", - "ease", - "though", + "characterized", + "metal", "nearly", + "reactions", + "interconversion", + "furthermore", + "exceptionally", + "enabled", "thiol", - "permutations", - "framework", - "accelerate", - "transformations", - "molecular", - "expected", "frameworks", - "conditions", - "assemblies", - "calculations", - "reactions", - "redox", - "active", - "landscape", - "synthesis", - "engineering", + "positive", + "sites", + "characterization", + "ions", "several", + "nitric", + "mild", + "including", + "supporting", + "peptide", + "undergo", + "permutations", + "redox", + "toxic", "design", - "functionality", - "characterization", - "cooperative", - "using", - "exceptionally", - "negative", "displayed", - "high", - "importantly", - "underlying", - "nitric", - "notably", - "hindered", - "ion", - "sites", "diverse", - "leveraging", - "delivery", - "noncovalent", - "undergo", - "observations", - "applicable", + "active", + "assembly", + "porous", + "rich", + "synthesis", + "selective", "also", - "rational", + "applicable", + "conditions", + "modularity", + "noncovalent", + "underlying", + "notably", + "oxide", + "versatile", + "reactive", + "landscape", + "unique", + "assemblies", + "materials", + "accelerate", + "cooperative", + "dynamics", "reveal", - "uptake", - "positive", - "selective", + "calculations", + "diffraction", + "many", + "importantly", + "structurally", + "rational", "synthesized", - "biocompatible", - "complex", + "determined", "thiols", - "readily", - "enabled", - "supporting" + "supports", + "interactions", + "ion", + "nature", + "find", + "transformations", + "uptake", + "high", + "negative", + "though", + "observations" ], "release_date":"2023-11-15", "publication":"\"Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks\", J.Am.Chem.Soc., 145, 19588-19600", @@ -680298,87 +683117,87 @@ "subtitle":"De novo design of monomeric helical bundles for ph-controlled membrane lysis", "tags":[ "de novo protein", - "membrane lysis", "protein design", - "ph-responsive" + "ph-responsive", + "membrane lysis" ], "keywords":[ + "lysis", + "membranes", + "designed", + "analysis", + "escherichia", + "design", + "controlled", + "intracellular", + "targeted", + "histidine", + "mutational", + "help", + "30", + "platforms", + "expressed", + "experimentally", "13", - "general", + "almost", "prevent", - "containing", - "analysis", - "control", - "designs", - "amphipathic", - "delivery", - "delivered", + "lytic", + "tested", + "monomers", + "via", "cargo", "monomeric", - "tested", - "expected", - "membranes", + "structure", + "within", + "delivery", + "insertion", + "model", + "escape", + "control", + "buried", + "ph", + "tightly", "membrane", - "via", - "restricted", + "endosomal", + "4", "proteins", - "helices", + "liposomes", "neutral", - "internalization", + "achieved", + "endocytosis", + "delivered", + "artificial", + "mediate", + "showed", + "degradation", + "endosome", + "networks", "coli", - "mutational", - "escape", - "principle", + "general", + "upon", "manner", - "intracellular", - "artificial", - "almost", - "expressed", - "disrupted", - "designed", - "4", - "controlled", - "liposomes", + "lysosomal", + "hydrogen", "requires", "small", - "targeted", - "endocytosis", - "permeating", - "experimentally", - "help", - "occurring", - "platforms", - "degradation", - "design", - "model", - "narrow", - "lysosomal", - "avoid", - "upon", - "buried", + "disrupted", + "expected", "bond", - "30", + "internalization", + "principle", + "permeating", "secondary", - "insertion", - "monomers", "describe", - "structure", - "showed", - "endosome", - "tightly", - "lysis", - "escherichia", - "networks", - "within", - "endosomal", - "histidine", - "mediate", + "helices", + "range", + "avoid", + "restricted", + "containing", + "amphipathic", + "designs", "could", - "ph", - "achieved", - "lytic", - "hydrogen", - "range" + "occurring", + "narrow" ], "release_date":"2023-09-06", "publication":"\"De novo design of monomeric helical bundles for pH-controlled membrane lysis\", Protein Sci., 32, e4769-e4769", @@ -680502,97 +683321,97 @@ "de novo protein" ], "keywords":[ - "many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - "mild", - "number", - "materials", - "nature", - "furthermore", - "modularity", - "dynamics", - "positions", - "assembly", - "ease", - "though", + "characterized", + "metal", "nearly", + "reactions", + "interconversion", + "furthermore", + "exceptionally", + "enabled", "thiol", - "permutations", - "framework", - "accelerate", - "transformations", - "molecular", - "expected", "frameworks", - "conditions", - "assemblies", - "calculations", - "reactions", - "redox", - "active", - "landscape", - "synthesis", - "engineering", + "positive", + "sites", + "characterization", + "ions", "several", + "nitric", + "mild", + "including", + "supporting", + "peptide", + "undergo", + "permutations", + "redox", + "toxic", "design", - "functionality", - "characterization", - "cooperative", - "using", - "exceptionally", - "negative", "displayed", - "high", - "importantly", - "underlying", - "nitric", - "notably", - "hindered", - "ion", - "sites", "diverse", - "leveraging", - "delivery", - "noncovalent", - "undergo", - "observations", - "applicable", + "active", + "assembly", + "porous", + "rich", + "synthesis", + "selective", "also", - "rational", + "applicable", + "conditions", + "modularity", + "noncovalent", + "underlying", + "notably", + "oxide", + "versatile", + "reactive", + "landscape", + "unique", + "assemblies", + "materials", + "accelerate", + "cooperative", + "dynamics", "reveal", - "uptake", - "positive", - "selective", + "calculations", + "diffraction", + "many", + "importantly", + "structurally", + "rational", "synthesized", - "biocompatible", - "complex", + "determined", "thiols", - "readily", - "enabled", - "supporting" + "supports", + "interactions", + "ion", + "nature", + "find", + "transformations", + "uptake", + "high", + "negative", + "though", + "observations" ], "release_date":"2023-11-15", "publication":"\"Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks\", J.Am.Chem.Soc., 145, 19588-19600", @@ -680713,97 +683532,97 @@ "de novo protein" ], "keywords":[ - "many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - "mild", - "number", - "materials", - "nature", - "furthermore", - "modularity", - "dynamics", - "positions", - "assembly", - "ease", - "though", + "characterized", + "metal", "nearly", + "reactions", + "interconversion", + "furthermore", + "exceptionally", + "enabled", "thiol", - "permutations", - "framework", - "accelerate", - "transformations", - "molecular", - "expected", "frameworks", - "conditions", - "assemblies", - "calculations", - "reactions", - "redox", - "active", - "landscape", - "synthesis", - "engineering", + "positive", + "sites", + "characterization", + "ions", "several", + "nitric", + "mild", + "including", + "supporting", + "peptide", + "undergo", + "permutations", + "redox", + "toxic", "design", - "functionality", - "characterization", - "cooperative", - "using", - "exceptionally", - "negative", "displayed", - "high", - "importantly", - "underlying", - "nitric", - "notably", - "hindered", - "ion", - "sites", "diverse", - "leveraging", - "delivery", - "noncovalent", - "undergo", - "observations", - "applicable", + "active", + "assembly", + "porous", + "rich", + "synthesis", + "selective", "also", - "rational", + "applicable", + "conditions", + "modularity", + "noncovalent", + "underlying", + "notably", + "oxide", + "versatile", + "reactive", + "landscape", + "unique", + "assemblies", + "materials", + "accelerate", + "cooperative", + "dynamics", "reveal", - "uptake", - "positive", - "selective", + "calculations", + "diffraction", + "many", + "importantly", + "structurally", + "rational", "synthesized", - "biocompatible", - "complex", + "determined", "thiols", - "readily", - "enabled", - "supporting" + "supports", + "interactions", + "ion", + "nature", + "find", + "transformations", + "uptake", + "high", + "negative", + "though", + "observations" ], "release_date":"2023-11-15", "publication":"\"Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks\", J.Am.Chem.Soc., 145, 19588-19600", @@ -681019,95 +683838,95 @@ "subtitle":"Backbone model of de novo-designed chlorophyll-binding nanocage o32-15", "tags":[ "helical repeats", - "octahedral symmetry", - "chlorophyll-binding", "de novo protein", + "chlorophyll-binding", + "octahedral symmetry", "nanocage" ], "keywords":[ - "results", "accepts", - "imaging", - "suggest", - "independently", - "crystallography", - "designed", - "current", - "couple", + "technologies", "methods", + "separation", + "within", + "results", + "new", + "model", "chlorophyll", - "complexities", - "synthetic", - "c", - "structure", - "fluorescence", - "harvesting", + "protein", + "positions", + "microscopy", + "pair", + "initiates", + "confirmed", + "novo", "photophysics", - "proteins", - "reach", - "technologies", - "de", - "edge", - "conversion", - "orientation", + "systems", + "two", "binds", - "separation", + "special", + "using", + "creating", + "independently", + "reach", + "cascade", "step", - "excitation", - "positions", - "natural", - "pairs", - "excitonically", - "native", - "revealed", - "first", - "second", - "molecules", - "coupled", + "charge", + "matched", + "complexities", + "proteins", "unseen", + "2", + "conversion", "octahedral", - "systems", - "previously", - "investigate", - "special", - "toward", - "demonstrated", - "geometry", + "harvesting", + "suggest", "antenna", - "photosynthetic", - "artificial", - "closely", - "transfer", - "photosystems", + "computational", + "pairs", + "investigate", + "c", "design", - "model", - "using", - "initiates", "energy", - "juxtaposed", - "one", - "novo", - "chlorophylls", - "lifetime", - "hold", - "matched", - "charge", "spectroscopy", - "confirmed", - "two", - "arrangements", - "creating", + "current", + "hold", + "natural", + "edge", + "orientation", + "excitonically", + "chlorophylls", "light", - "protein", - "microscopy", - "2", - "within", - "computational", + "demonstrated", + "toward", + "whereas", + "couple", + "lifetime", "nanocage", - "cascade", - "pair", - "new", - "whereas" + "designed", + "fluorescence", + "photosystems", + "revealed", + "juxtaposed", + "coupled", + "one", + "geometry", + "de", + "photosynthetic", + "first", + "previously", + "imaging", + "structure", + "synthetic", + "closely", + "crystallography", + "excitation", + "molecules", + "artificial", + "native", + "arrangements", + "second", + "transfer" ], "release_date":"2024-03-27", "publication":"\"De novo design of proteins housing excitonically coupled chlorophyll special pairs\", Nat.Chem.Biol., 20, 906-915", @@ -681138,22 +683957,6 @@ "previous_design":"8gl5", "next_design":"8h7c", "seq_thr_sim_designed":[ - { - "sim":391.0, - "partner":"7uni" - }, - { - "sim":390.0, - "partner":"7unh" - }, - { - "sim":53.0, - "partner":"8tlp" - }, - { - "sim":52.0, - "partner":"8tm9" - }, { "sim":169.0, "partner":"8fwd" @@ -681217,6 +684020,22 @@ { "sim":51.0, "partner":"6n4n" + }, + { + "sim":391.0, + "partner":"7uni" + }, + { + "sim":390.0, + "partner":"7unh" + }, + { + "sim":53.0, + "partner":"8tlp" + }, + { + "sim":52.0, + "partner":"8tm9" } ], "seq_thr_sim_natural":[ @@ -681305,121 +684124,121 @@ ], "subtitle":"Crystal structure of a de novo enzyme, ferric enterobactin esterase syn-f4 (k4t) - pt derivative", "tags":[ - "de novo enzyme", "ferric enterobactin esterase", - "binary patterned library", "de novo protein", + "binary patterned library", + "de novo enzyme", "dimeric 4-helix bundle" ], "keywords":[ - "located", - "long", - "dyad", - "fes", - "designed", - "inviable", - "mutations", - "provide", - "dimeric", + "escherichia", + "interestingly", + "molecular", + "his74", + "arose", + "key", + "hole", + "around", + "ferric", + "docking", + "protein", + "study", + "activities", + "vitro", + "binding", + "showed", + "essential", + "extensive", + "site", + "novo", + "demonstrate", + "forms", + "meets", + "catalytic", + "two", "purified", "crystal", - "complete", - "expression", - "catalytically", - "synthetic", - "penetrated", - "\u03b4", - "structure", - "docking", - "allowed", - "escherichia", - "monomer", - "novel", - "glu26", + "region", "inactivity", "syn", - "topology", - "suggesting", - "supports", - "proteins", - "putative", - "de", - "enzymes", - "ferric", - "meets", - "strain", - "dramatically", + "using", + "lys78", + "previous", + "reaction", "goal", + "simulations", + "producing", + "enterobactin", + "dynamic", + "mechanisms", "arg85", + "\u03b4", + "dimer", + "comprises", + "residues", + "grow", + "completely", + "proteins", "criteria", + "end", + "enzymes", + "fes", + "penetrated", + "suggesting", + "monomer", "demonstrating", - "nature", - "vitro", - "siderophore", - "dynamics", - "structures", - "dynamic", - "essential", - "showed", - "native", - "biology", - "extensive", - "first", - "previously", - "esterase", - "reported", - "molecular", + "long", + "bundle", + "property", + "mutagenesis", + "catalytically", + "strain", + "topology", + "active", "loops", "functional", - "thereby", + "biology", + "different", + "glu26", + "experiments", + "complete", + "siderophore", "coli", - "catalytic", - "activities", - "arose", - "active", - "dimer", - "region", - "producing", - "activity", - "simulations", - "medium", - "bundle", - "interestingly", - "mutagenesis", - "using", + "reported", "describe", - "property", - "key", - "grow", - "around", - "completely", - "demonstrate", - "hole", - "study", - "hydrolyzed", - "novo", - "experiments", - "biologically", - "enzymatic", - "different", - "residues", - "enterobactin", - "his74", - "reaction", - "lys78", - "two", - "comprises", - "central", "mechanism", - "binding", - "protein", - "previous", - "mechanisms", - "end", + "dynamics", + "designed", + "central", + "medium", "vivo", + "mutations", + "esterase", + "structures", + "de", + "putative", + "first", + "previously", + "allowed", + "enzymatic", + "structure", + "synthetic", + "thereby", + "provide", "arg77", - "site", - "forms", + "supports", + "biologically", + "nature", + "hydrolyzed", + "dramatically", + "inviable", + "located", + "dyad", + "activity", + "native", + "expression", + "novel", + "dimeric", "five" ], "release_date":"2023-09-20", @@ -681453,11 +684272,11 @@ "seq_thr_sim_designed":[ { "sim":215.0, - "partner":"8h7d" + "partner":"8h7e" }, { "sim":215.0, - "partner":"8h7e" + "partner":"8h7d" }, { "sim":96.0, @@ -681486,7 +684305,7 @@ ], "seq_max_sim_designed":{ "sim":215.0, - "partner":"8h7d" + "partner":"8h7e" }, "seq_max_sim_natural":[ @@ -681555,121 +684374,121 @@ ], "subtitle":"Crystal structure of a de novo enzyme, ferric enterobactin esterase syn-f4 (k4t)", "tags":[ - "de novo enzyme", "ferric enterobactin esterase", - "binary patterned library", "de novo protein", + "binary patterned library", + "de novo enzyme", "dimeric 4-helix bundle" ], "keywords":[ - "located", - "long", - "dyad", - "fes", - "designed", - "inviable", - "mutations", - "provide", - "dimeric", + "escherichia", + "interestingly", + "molecular", + "his74", + "arose", + "key", + "hole", + "around", + "ferric", + "docking", + "protein", + "study", + "activities", + "vitro", + "binding", + "showed", + "essential", + "extensive", + "site", + "novo", + "demonstrate", + "forms", + "meets", + "catalytic", + "two", "purified", "crystal", - "complete", - "expression", - "catalytically", - "synthetic", - "penetrated", - "\u03b4", - "structure", - "docking", - "allowed", - "escherichia", - "monomer", - "novel", - "glu26", + "region", "inactivity", "syn", - "topology", - "suggesting", - "supports", - "proteins", - "putative", - "de", - "enzymes", - "ferric", - "meets", - "strain", - "dramatically", + "using", + "lys78", + "previous", + "reaction", "goal", + "simulations", + "producing", + "enterobactin", + "dynamic", + "mechanisms", "arg85", + "\u03b4", + "dimer", + "comprises", + "residues", + "grow", + "completely", + "proteins", "criteria", + "end", + "enzymes", + "fes", + "penetrated", + "suggesting", + "monomer", "demonstrating", - "nature", - "vitro", - "siderophore", - "dynamics", - "structures", - "dynamic", - "essential", - "showed", - "native", - "biology", - "extensive", - "first", - "previously", - "esterase", - "reported", - "molecular", + "long", + "bundle", + "property", + "mutagenesis", + "catalytically", + "strain", + "topology", + "active", "loops", "functional", - "thereby", + "biology", + "different", + "glu26", + "experiments", + "complete", + "siderophore", "coli", - "catalytic", - "activities", - "arose", - "active", - "dimer", - "region", - "producing", - "activity", - "simulations", - "medium", - "bundle", - "interestingly", - "mutagenesis", - "using", + "reported", "describe", - "property", - "key", - "grow", - "around", - "completely", - "demonstrate", - "hole", - "study", - "hydrolyzed", - "novo", - "experiments", - "biologically", - "enzymatic", - "different", - "residues", - "enterobactin", - "his74", - "reaction", - "lys78", - "two", - "comprises", - "central", "mechanism", - "binding", - "protein", - "previous", - "mechanisms", - "end", + "dynamics", + "designed", + "central", + "medium", "vivo", + "mutations", + "esterase", + "structures", + "de", + "putative", + "first", + "previously", + "allowed", + "enzymatic", + "structure", + "synthetic", + "thereby", + "provide", "arg77", - "site", - "forms", + "supports", + "biologically", + "nature", + "hydrolyzed", + "dramatically", + "inviable", + "located", + "dyad", + "activity", + "native", + "expression", + "novel", + "dimeric", "five" ], "release_date":"2023-09-20", @@ -681805,121 +684624,121 @@ ], "subtitle":"Crystal structure of a de novo enzyme, ferric enterobactin esterase syn-f4 (k4t) at 2.0 angstrom resolution", "tags":[ - "de novo enzyme", "ferric enterobactin esterase", - "binary patterned library", "de novo protein", + "binary patterned library", + "de novo enzyme", "dimeric 4-helix bundle" ], "keywords":[ - "located", - "long", - "dyad", - "fes", - "designed", - "inviable", - "mutations", - "provide", - "dimeric", + "escherichia", + "interestingly", + "molecular", + "his74", + "arose", + "key", + "hole", + "around", + "ferric", + "docking", + "protein", + "study", + "activities", + "vitro", + "binding", + "showed", + "essential", + "extensive", + "site", + "novo", + "demonstrate", + "forms", + "meets", + "catalytic", + "two", "purified", "crystal", - "complete", - "expression", - "catalytically", - "synthetic", - "penetrated", - "\u03b4", - "structure", - "docking", - "allowed", - "escherichia", - "monomer", - "novel", - "glu26", + "region", "inactivity", "syn", - "topology", - "suggesting", - "supports", - "proteins", - "putative", - "de", - "enzymes", - "ferric", - "meets", - "strain", - "dramatically", + "using", + "lys78", + "previous", + "reaction", "goal", + "simulations", + "producing", + "enterobactin", + "dynamic", + "mechanisms", "arg85", + "\u03b4", + "dimer", + "comprises", + "residues", + "grow", + "completely", + "proteins", "criteria", + "end", + "enzymes", + "fes", + "penetrated", + "suggesting", + "monomer", "demonstrating", - "nature", - "vitro", - "siderophore", - "dynamics", - "structures", - "dynamic", - "essential", - "showed", - "native", - "biology", - "extensive", - "first", - "previously", - "esterase", - "reported", - "molecular", + "long", + "bundle", + "property", + "mutagenesis", + "catalytically", + "strain", + "topology", + "active", "loops", "functional", - "thereby", + "biology", + "different", + "glu26", + "experiments", + "complete", + "siderophore", "coli", - "catalytic", - "activities", - "arose", - "active", - "dimer", - "region", - "producing", - "activity", - "simulations", - "medium", - "bundle", - "interestingly", - "mutagenesis", - "using", + "reported", "describe", - "property", - "key", - "grow", - "around", - "completely", - "demonstrate", - "hole", - "study", - "hydrolyzed", - "novo", - "experiments", - "biologically", - "enzymatic", - "different", - "residues", - "enterobactin", - "his74", - "reaction", - "lys78", - "two", - "comprises", - "central", "mechanism", - "binding", - "protein", - "previous", - "mechanisms", - "end", + "dynamics", + "designed", + "central", + "medium", "vivo", + "mutations", + "esterase", + "structures", + "de", + "putative", + "first", + "previously", + "allowed", + "enzymatic", + "structure", + "synthetic", + "thereby", + "provide", "arg77", - "site", - "forms", + "supports", + "biologically", + "nature", + "hydrolyzed", + "dramatically", + "inviable", + "located", + "dyad", + "activity", + "native", + "expression", + "novel", + "dimeric", "five" ], "release_date":"2023-09-20", @@ -681953,11 +684772,11 @@ "seq_thr_sim_designed":[ { "sim":215.0, - "partner":"8h7d" + "partner":"8h7c" }, { "sim":215.0, - "partner":"8h7c" + "partner":"8h7d" }, { "sim":96.0, @@ -681986,7 +684805,7 @@ ], "seq_max_sim_designed":{ "sim":215.0, - "partner":"8h7d" + "partner":"8h7c" }, "seq_max_sim_natural":[ @@ -682051,75 +684870,75 @@ ], "subtitle":"De novo design cavitated protein without predefined topology", "tags":[ - "cavitated protein", "de novo protein", + "cavitated protein", "de novo design" ], "keywords":[ - "great", + "designed", + "designing", + "introducing", + "naturally", + "design", + "sampling", + "energy", + "cavities", + "backbones", + "521", + "one", + "indicate", + "tailored", "diverse", - "statistical", + "methods", + "structures", + "hold", + "de", + "efforts", + "rmsds", + "agreement", + "dimer", + "experimentally", + "side", + "based", + "potential", + "\u00e5", + "tested", "without", - "architectures", - "restraints", - "designs", - "deviations", + "c\u03b1", "predefined", - "arrangement", - "tested", - "tailored", + "atoms", + "deviations", + "within", + "partial", + "results", + "determined", + "great", + "driven", + "closely", + "model", + "protein", "network", - "one", + "architectures", + "function", "proteins", - "results", + "neural", "5816", - "de", - "rmsds", + "backbone", + "occurring", "novo", - "efforts", - "driven", - "\u00e5", - "hold", - "designed", - "atoms", - "10", + "agrees", "requires", - "closely", - "dimer", - "agreement", - "521", + "arrangement", + "forms", + "contain", "two", - "experimentally", "crystal", - "methods", - "occurring", - "determined", - "potential", - "based", - "design", - "sampling", - "model", - "partial", - "structures", - "protein", - "naturally", + "designs", "scuba", + "10", + "restraints", "previous", - "backbone", - "agrees", - "designing", - "c\u03b1", - "neural", - "cavities", - "function", - "indicate", - "energy", - "within", - "introducing", - "side", - "backbones", - "forms", - "contain" + "statistical" ], "release_date":"2023-01-18", "publication":"\"De novo design of cavity-containing proteins with a backbone-centered neural network energy function\", Structure, 32, 424", @@ -682156,39 +684975,39 @@ }, { "sim":88.0, - "partner":"8j1x" + "partner":"8j98" }, { "sim":88.0, - "partner":"8j98" + "partner":"8j1x" }, { "sim":84.0, - "partner":"8jpa" + "partner":"8hdv" }, { "sim":84.0, - "partner":"8hdv" + "partner":"8jpa" }, { "sim":57.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":57.0, - "partner":"8v2x" + "partner":"8v09" }, { "sim":57.0, - "partner":"8w08" + "partner":"8v2w" }, { "sim":57.0, - "partner":"8v2w" + "partner":"8v2x" }, { "sim":57.0, - "partner":"8v09" + "partner":"8v0a" }, { "sim":55.0, @@ -682196,11 +685015,11 @@ }, { "sim":55.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":55.0, - "partner":"8w05" + "partner":"8w06" }, { "sim":54.0, @@ -682258,11 +685077,11 @@ }, { "sim":77.0, - "partner":"6mwy" + "partner":"6myl" }, { "sim":77.0, - "partner":"6myl" + "partner":"6mwy" }, { "sim":77.0, @@ -682380,10 +685199,6 @@ "sim":74.0, "partner":"5c2o" }, - { - "sim":74.0, - "partner":"4m02" - }, { "sim":74.0, "partner":"3zez" @@ -682416,6 +685231,10 @@ "sim":74.0, "partner":"3zf6" }, + { + "sim":74.0, + "partner":"4m02" + }, { "sim":74.0, "partner":"3s2s" @@ -682450,11 +685269,11 @@ }, { "sim":74.0, - "partner":"3la8" + "partner":"3lba" }, { "sim":74.0, - "partner":"3lba" + "partner":"3la8" }, { "sim":74.0, @@ -682504,6 +685323,18 @@ "sim":74.0, "partner":"6lkc" }, + { + "sim":74.0, + "partner":"8vjq" + }, + { + "sim":74.0, + "partner":"8vix" + }, + { + "sim":74.0, + "partner":"8vh0" + }, { "sim":73.0, "partner":"2kg1" @@ -682576,10 +685407,6 @@ "sim":73.0, "partner":"3roj" }, - { - "sim":73.0, - "partner":"6jtl" - }, { "sim":73.0, "partner":"6jti" @@ -682592,6 +685419,10 @@ "sim":73.0, "partner":"6jtk" }, + { + "sim":73.0, + "partner":"6jtl" + }, { "sim":73.0, "partner":"5jzx" @@ -682694,11 +685525,11 @@ }, { "sim":72.0, - "partner":"6hjm" + "partner":"4ofa" }, { "sim":72.0, - "partner":"4ofa" + "partner":"6hjm" }, { "sim":72.0, @@ -682732,18 +685563,6 @@ "sim":72.0, "partner":"5myi" }, - { - "sim":72.0, - "partner":"7ex2" - }, - { - "sim":72.0, - "partner":"7ex3" - }, - { - "sim":72.0, - "partner":"7ex4" - }, { "sim":72.0, "partner":"7ex6" @@ -682786,15 +685605,23 @@ }, { "sim":72.0, - "partner":"5ygv" + "partner":"7ex2" }, { "sim":72.0, - "partner":"3wg8" + "partner":"7ex3" }, { "sim":72.0, - "partner":"2uxx" + "partner":"7ex4" + }, + { + "sim":72.0, + "partner":"5ygv" + }, + { + "sim":72.0, + "partner":"3wg8" }, { "sim":72.0, @@ -682808,6 +685635,10 @@ "sim":72.0, "partner":"4kum" }, + { + "sim":72.0, + "partner":"2uxx" + }, { "sim":72.0, "partner":"3dez" @@ -682818,11 +685649,11 @@ }, { "sim":72.0, - "partner":"5feu" + "partner":"6y4d" }, { "sim":72.0, - "partner":"6y4d" + "partner":"5feu" }, { "sim":72.0, @@ -682900,10 +685731,6 @@ "sim":72.0, "partner":"4hbk" }, - { - "sim":72.0, - "partner":"7dw8" - }, { "sim":72.0, "partner":"7dwa" @@ -682920,6 +685747,10 @@ "sim":72.0, "partner":"7dvj" }, + { + "sim":72.0, + "partner":"7dw8" + }, { "sim":72.0, "partner":"5xm6" @@ -682958,27 +685789,27 @@ }, { "sim":72.0, - "partner":"6alm" + "partner":"6alo" }, { "sim":72.0, - "partner":"6aln" + "partner":"6alp" }, { "sim":72.0, - "partner":"6alo" + "partner":"6alq" }, { "sim":72.0, - "partner":"6alp" + "partner":"6alr" }, { "sim":72.0, - "partner":"6alq" + "partner":"6alm" }, { "sim":72.0, - "partner":"6alr" + "partner":"6aln" }, { "sim":72.0, @@ -682988,10 +685819,6 @@ "sim":72.0, "partner":"4irn" }, - { - "sim":72.0, - "partner":"3pln" - }, { "sim":72.0, "partner":"3phl" @@ -683006,15 +685833,15 @@ }, { "sim":72.0, - "partner":"6ix2" + "partner":"3pln" }, { "sim":72.0, - "partner":"3pid" + "partner":"6ix2" }, { "sim":72.0, - "partner":"3nc3" + "partner":"3pid" }, { "sim":72.0, @@ -683030,16 +685857,20 @@ }, { "sim":72.0, - "partner":"7oq6" + "partner":"3nc3" }, { "sim":72.0, - "partner":"4nxl" + "partner":"7oq6" }, { "sim":72.0, "partner":"4jek" }, + { + "sim":72.0, + "partner":"4nxl" + }, { "sim":72.0, "partner":"6gii" @@ -683102,28 +685933,20 @@ }, { "sim":72.0, - "partner":"6unz" - }, - { - "sim":72.0, - "partner":"6uoj" + "partner":"6msn" }, { "sim":72.0, - "partner":"6upo" + "partner":"6unz" }, { "sim":72.0, - "partner":"6msn" + "partner":"6uq8" }, { "sim":72.0, "partner":"5l2r" }, - { - "sim":72.0, - "partner":"6uq8" - }, { "sim":72.0, "partner":"6uo0" @@ -683160,6 +685983,14 @@ "sim":72.0, "partner":"6up9" }, + { + "sim":72.0, + "partner":"6uoj" + }, + { + "sim":72.0, + "partner":"6upo" + }, { "sim":72.0, "partner":"4e85" @@ -683226,11 +686057,11 @@ }, { "sim":71.0, - "partner":"5nbt" + "partner":"6gzc" }, { "sim":71.0, - "partner":"6gzc" + "partner":"5nbt" }, { "sim":71.0, @@ -683414,11 +686245,11 @@ }, { "sim":70.0, - "partner":"6isk" + "partner":"6isl" }, { "sim":70.0, - "partner":"6isl" + "partner":"6isk" }, { "sim":70.0, @@ -683460,10 +686291,6 @@ "sim":70.0, "partner":"5jre" }, - { - "sim":70.0, - "partner":"5nbh" - }, { "sim":70.0, "partner":"5n8d" @@ -683476,6 +686303,10 @@ "sim":70.0, "partner":"5n83" }, + { + "sim":70.0, + "partner":"5nbh" + }, { "sim":70.0, "partner":"7x5t" @@ -683502,11 +686333,11 @@ }, { "sim":70.0, - "partner":"6pei" + "partner":"6pej" }, { "sim":70.0, - "partner":"6pej" + "partner":"6pei" }, { "sim":70.0, @@ -683528,10 +686359,6 @@ "sim":70.0, "partner":"5yjl" }, - { - "sim":70.0, - "partner":"5yoi" - }, { "sim":70.0, "partner":"5ypj" @@ -683548,6 +686375,10 @@ "sim":70.0, "partner":"5yoh" }, + { + "sim":70.0, + "partner":"5yoi" + }, { "sim":70.0, "partner":"3pl5" @@ -683586,15 +686417,11 @@ }, { "sim":70.0, - "partner":"7cm8" - }, - { - "sim":70.0, - "partner":"7djq" + "partner":"7c35" }, { "sim":70.0, - "partner":"7c35" + "partner":"7ewo" }, { "sim":70.0, @@ -683610,7 +686437,7 @@ }, { "sim":70.0, - "partner":"7ewo" + "partner":"7cm8" }, { "sim":70.0, @@ -683618,11 +686445,11 @@ }, { "sim":70.0, - "partner":"7cd5" + "partner":"7djq" }, { "sim":70.0, - "partner":"3tro" + "partner":"7cd5" }, { "sim":70.0, @@ -683632,6 +686459,10 @@ "sim":70.0, "partner":"7myd" }, + { + "sim":70.0, + "partner":"3tro" + }, { "sim":70.0, "partner":"4m01" @@ -683650,15 +686481,15 @@ }, { "sim":70.0, - "partner":"8uen" + "partner":"8uro" }, { "sim":70.0, - "partner":"8ura" + "partner":"8uen" }, { "sim":70.0, - "partner":"8uro" + "partner":"8ura" }, { "sim":70.0, @@ -683678,23 +686509,23 @@ }, { "sim":70.0, - "partner":"7ffg" + "partner":"7ffi" }, { "sim":70.0, - "partner":"7ffh" + "partner":"7ffa" }, { "sim":70.0, - "partner":"7ffi" + "partner":"7ffc" }, { "sim":70.0, - "partner":"7ffa" + "partner":"7ffg" }, { "sim":70.0, - "partner":"7ffc" + "partner":"7ffh" }, { "sim":70.0, @@ -683742,11 +686573,11 @@ }, { "sim":70.0, - "partner":"3l7r" + "partner":"3t0c" }, { "sim":70.0, - "partner":"3t0c" + "partner":"3l7r" }, { "sim":70.0, @@ -683754,15 +686585,15 @@ }, { "sim":69.0, - "partner":"4d1f" + "partner":"4d1g" }, { "sim":69.0, - "partner":"4d1g" + "partner":"4d0u" }, { "sim":69.0, - "partner":"4d0u" + "partner":"4d1f" }, { "sim":69.0, @@ -683800,17 +686631,13 @@ "sim":69.0, "partner":"4f6c" }, - { - "sim":69.0, - "partner":"7q9z" - }, { "sim":69.0, "partner":"7q9x" }, { "sim":69.0, - "partner":"4bzc" + "partner":"7q9z" }, { "sim":69.0, @@ -683818,16 +686645,12 @@ }, { "sim":69.0, - "partner":"6dwk" + "partner":"6dwd" }, { "sim":69.0, "partner":"4qg2" }, - { - "sim":69.0, - "partner":"6dwd" - }, { "sim":69.0, "partner":"7s2y" @@ -683877,13 +686700,21 @@ "partner":"4qg0" }, { - "sim":68.0, - "partner":"3ul6" + "sim":69.0, + "partner":"6dwk" + }, + { + "sim":69.0, + "partner":"4bzc" }, { "sim":68.0, "partner":"3ul5" }, + { + "sim":68.0, + "partner":"3ul6" + }, { "sim":68.0, "partner":"5fld" @@ -683908,10 +686739,6 @@ "sim":68.0, "partner":"2fi7" }, - { - "sim":68.0, - "partner":"2zbb" - }, { "sim":68.0, "partner":"3e4o" @@ -683924,6 +686751,10 @@ "sim":68.0, "partner":"3e4q" }, + { + "sim":68.0, + "partner":"2zbb" + }, { "sim":68.0, "partner":"4nv7" @@ -684218,11 +687049,11 @@ }, { "sim":57.0, - "partner":"6wa9" + "partner":"6wa6" }, { "sim":57.0, - "partner":"6wa6" + "partner":"6wa9" }, { "sim":57.0, @@ -684234,15 +687065,15 @@ }, { "sim":56.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":56.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":56.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":56.0, @@ -684298,15 +687129,15 @@ }, { "sim":56.0, - "partner":"5kdn" + "partner":"5kds" }, { "sim":56.0, - "partner":"5kds" + "partner":"5kdu" }, { "sim":56.0, - "partner":"5kdu" + "partner":"5kdn" }, { "sim":56.0, @@ -684338,19 +687169,19 @@ }, { "sim":55.0, - "partner":"1x24" + "partner":"4gzd" }, { "sim":55.0, - "partner":"4gzc" + "partner":"1zcl" }, { "sim":55.0, - "partner":"4gzd" + "partner":"1x24" }, { "sim":55.0, - "partner":"1zcl" + "partner":"4gzc" }, { "sim":55.0, @@ -684388,14 +687219,6 @@ "sim":55.0, "partner":"2fg7" }, - { - "sim":55.0, - "partner":"5gg5" - }, - { - "sim":55.0, - "partner":"5xd1" - }, { "sim":55.0, "partner":"5gg6" @@ -684410,27 +687233,27 @@ }, { "sim":55.0, - "partner":"5gg7" + "partner":"6m6y" }, { "sim":55.0, - "partner":"5xd4" + "partner":"5gg7" }, { "sim":55.0, - "partner":"5xd5" + "partner":"5xd4" }, { "sim":55.0, - "partner":"6m6y" + "partner":"6m65" }, { "sim":55.0, - "partner":"5gg8" + "partner":"5xd5" }, { "sim":55.0, - "partner":"6m65" + "partner":"5gg8" }, { "sim":55.0, @@ -684460,6 +687283,14 @@ "sim":55.0, "partner":"6m69" }, + { + "sim":55.0, + "partner":"5gg5" + }, + { + "sim":55.0, + "partner":"5xd1" + }, { "sim":55.0, "partner":"3i8v" @@ -684498,28 +687329,12 @@ }, { "sim":55.0, - "partner":"4wya" - }, - { - "sim":55.0, - "partner":"4wyf" - }, - { - "sim":55.0, - "partner":"4cxq" - }, - { - "sim":55.0, - "partner":"5kgs" + "partner":"4cxr" }, { "sim":55.0, "partner":"4wyg" }, - { - "sim":55.0, - "partner":"4cxr" - }, { "sim":55.0, "partner":"4xjl" @@ -684584,10 +687399,26 @@ "sim":55.0, "partner":"3tfu" }, + { + "sim":55.0, + "partner":"4wya" + }, { "sim":55.0, "partner":"4wye" }, + { + "sim":55.0, + "partner":"4wyf" + }, + { + "sim":55.0, + "partner":"4cxq" + }, + { + "sim":55.0, + "partner":"5kgs" + }, { "sim":55.0, "partner":"4b28" @@ -684602,15 +687433,15 @@ }, { "sim":55.0, - "partner":"5tsh" + "partner":"6olj" }, { "sim":55.0, - "partner":"6olj" + "partner":"5tsg" }, { "sim":55.0, - "partner":"5tsg" + "partner":"5tsh" }, { "sim":55.0, @@ -684686,11 +687517,11 @@ }, { "sim":54.0, - "partner":"4f0v" + "partner":"4f0w" }, { "sim":54.0, - "partner":"4f0w" + "partner":"4f0v" }, { "sim":54.0, @@ -684700,10 +687531,6 @@ "sim":54.0, "partner":"6plj" }, - { - "sim":54.0, - "partner":"6o98" - }, { "sim":54.0, "partner":"7jh2" @@ -684718,11 +687545,7 @@ }, { "sim":54.0, - "partner":"7kqj" - }, - { - "sim":54.0, - "partner":"6vqf" + "partner":"6o98" }, { "sim":54.0, @@ -684768,6 +687591,14 @@ "sim":54.0, "partner":"7luk" }, + { + "sim":54.0, + "partner":"6vqf" + }, + { + "sim":54.0, + "partner":"7kqj" + }, { "sim":54.0, "partner":"5ldb" @@ -684810,15 +687641,15 @@ }, { "sim":54.0, - "partner":"4w7v" + "partner":"4w7u" }, { "sim":54.0, - "partner":"4w7w" + "partner":"4w7v" }, { "sim":54.0, - "partner":"4w7u" + "partner":"4w7w" }, { "sim":54.0, @@ -684828,10 +687659,6 @@ "sim":54.0, "partner":"5hpc" }, - { - "sim":54.0, - "partner":"6put" - }, { "sim":54.0, "partner":"6puw" @@ -684844,13 +687671,17 @@ "sim":54.0, "partner":"6v3k" }, + { + "sim":54.0, + "partner":"6puz" + }, { "sim":54.0, "partner":"5u1c" }, { "sim":54.0, - "partner":"6puz" + "partner":"6put" }, { "sim":54.0, @@ -684984,10 +687815,6 @@ "sim":53.0, "partner":"3o5s" }, - { - "sim":53.0, - "partner":"5cvd" - }, { "sim":53.0, "partner":"5cve" @@ -685000,6 +687827,10 @@ "sim":53.0, "partner":"3qc1" }, + { + "sim":53.0, + "partner":"5cvd" + }, { "sim":53.0, "partner":"6iz8" @@ -685028,10 +687859,6 @@ "sim":53.0, "partner":"5ltv" }, - { - "sim":53.0, - "partner":"3dbp" - }, { "sim":53.0, "partner":"3mo7" @@ -685054,7 +687881,7 @@ }, { "sim":53.0, - "partner":"4rni" + "partner":"3dbp" }, { "sim":53.0, @@ -685062,7 +687889,7 @@ }, { "sim":53.0, - "partner":"3p8e" + "partner":"4rni" }, { "sim":53.0, @@ -685080,6 +687907,10 @@ "sim":53.0, "partner":"3p8p" }, + { + "sim":53.0, + "partner":"3p8e" + }, { "sim":53.0, "partner":"6oxh" @@ -685110,15 +687941,15 @@ }, { "sim":53.0, - "partner":"2pzm" + "partner":"2pzk" }, { "sim":53.0, - "partner":"2pzk" + "partner":"2pzl" }, { "sim":53.0, - "partner":"2pzl" + "partner":"2pzm" }, { "sim":53.0, @@ -685136,10 +687967,6 @@ "sim":53.0, "partner":"1qyu" }, - { - "sim":53.0, - "partner":"7ajm" - }, { "sim":53.0, "partner":"7a4r" @@ -685154,23 +687981,7 @@ }, { "sim":53.0, - "partner":"7a53" - }, - { - "sim":53.0, - "partner":"7ajw" - }, - { - "sim":53.0, - "partner":"7akb" - }, - { - "sim":53.0, - "partner":"7ajy" - }, - { - "sim":53.0, - "partner":"7a5l" + "partner":"7ajm" }, { "sim":53.0, @@ -685232,25 +688043,37 @@ "sim":53.0, "partner":"7aka" }, + { + "sim":53.0, + "partner":"7a53" + }, { "sim":53.0, "partner":"7akl" }, { "sim":53.0, - "partner":"8t0w" + "partner":"7ajw" }, { "sim":53.0, - "partner":"8t0u" + "partner":"7akb" }, { "sim":53.0, - "partner":"3dyh" + "partner":"7ajy" }, { "sim":53.0, - "partner":"4rxd" + "partner":"7a5l" + }, + { + "sim":53.0, + "partner":"8t0w" + }, + { + "sim":53.0, + "partner":"8t0u" }, { "sim":53.0, @@ -685292,6 +688115,14 @@ "sim":53.0, "partner":"3dyg" }, + { + "sim":53.0, + "partner":"4rxd" + }, + { + "sim":53.0, + "partner":"3dyh" + }, { "sim":53.0, "partner":"7jyb" @@ -685326,31 +688157,31 @@ }, { "sim":53.0, - "partner":"6ry0" + "partner":"6ry5" }, { "sim":53.0, - "partner":"6ry1" + "partner":"6ry6" }, { "sim":53.0, - "partner":"6ry2" + "partner":"6ry7" }, { "sim":53.0, - "partner":"6ry5" + "partner":"3zpp" }, { "sim":53.0, - "partner":"6ry6" + "partner":"6ry0" }, { "sim":53.0, - "partner":"6ry7" + "partner":"6ry1" }, { "sim":53.0, - "partner":"3zpp" + "partner":"6ry2" }, { "sim":53.0, @@ -685358,11 +688189,11 @@ }, { "sim":53.0, - "partner":"3pq1" + "partner":"7tf9" }, { "sim":53.0, - "partner":"7tf9" + "partner":"3pq1" }, { "sim":53.0, @@ -685374,11 +688205,11 @@ }, { "sim":53.0, - "partner":"5dt7" + "partner":"5dt5" }, { "sim":53.0, - "partner":"5dt5" + "partner":"5dt7" }, { "sim":53.0, @@ -685398,11 +688229,11 @@ }, { "sim":53.0, - "partner":"4mdo" + "partner":"4mdp" }, { "sim":53.0, - "partner":"4mdp" + "partner":"4mdo" }, { "sim":53.0, @@ -685434,15 +688265,15 @@ }, { "sim":53.0, - "partner":"2vbg" + "partner":"2vbf" }, { "sim":53.0, - "partner":"2vbf" + "partner":"2vbg" }, { "sim":53.0, - "partner":"5m12" + "partner":"6gwg" }, { "sim":53.0, @@ -685450,31 +688281,31 @@ }, { "sim":53.0, - "partner":"6gwf" + "partner":"6gta" }, { "sim":53.0, - "partner":"6gwg" + "partner":"5m16" }, { "sim":53.0, - "partner":"5m16" + "partner":"6gvd" }, { "sim":53.0, - "partner":"6gta" + "partner":"5m0x" }, { "sim":53.0, - "partner":"6gvd" + "partner":"6gx8" }, { "sim":53.0, - "partner":"5m0x" + "partner":"5m12" }, { "sim":53.0, - "partner":"6gx8" + "partner":"6gwf" }, { "sim":53.0, @@ -685676,10 +688507,6 @@ "sim":52.0, "partner":"2m70" }, - { - "sim":52.0, - "partner":"7vo0" - }, { "sim":52.0, "partner":"7x76" @@ -685706,11 +688533,7 @@ }, { "sim":52.0, - "partner":"5scp" - }, - { - "sim":52.0, - "partner":"5scq" + "partner":"7vo0" }, { "sim":52.0, @@ -685812,6 +688635,14 @@ "sim":52.0, "partner":"5sco" }, + { + "sim":52.0, + "partner":"5scp" + }, + { + "sim":52.0, + "partner":"5scq" + }, { "sim":52.0, "partner":"6gum" @@ -685828,10 +688659,6 @@ "sim":52.0, "partner":"7l8r" }, - { - "sim":52.0, - "partner":"5l9k" - }, { "sim":52.0, "partner":"5l9q" @@ -685848,6 +688675,10 @@ "sim":52.0, "partner":"5lbp" }, + { + "sim":52.0, + "partner":"5l9k" + }, { "sim":52.0, "partner":"4jwl" @@ -685884,10 +688715,6 @@ "sim":52.0, "partner":"1wc5" }, - { - "sim":52.0, - "partner":"6a98" - }, { "sim":52.0, "partner":"6a99" @@ -685898,12 +688725,16 @@ }, { "sim":52.0, - "partner":"1wc6" + "partner":"6a98" }, { "sim":52.0, "partner":"1wc1" }, + { + "sim":52.0, + "partner":"1wc6" + }, { "sim":52.0, "partner":"6q2s" @@ -685936,14 +688767,6 @@ "sim":52.0, "partner":"5dtz" }, - { - "sim":52.0, - "partner":"6tlm" - }, - { - "sim":52.0, - "partner":"6tlq" - }, { "sim":52.0, "partner":"6tlt" @@ -685976,6 +688799,14 @@ "sim":52.0, "partner":"6t50" }, + { + "sim":52.0, + "partner":"6tlm" + }, + { + "sim":52.0, + "partner":"6tlq" + }, { "sim":52.0, "partner":"5du0" @@ -686054,31 +688885,31 @@ }, { "sim":52.0, - "partner":"3quo" + "partner":"3qur" }, { "sim":52.0, - "partner":"3qvf" + "partner":"3qvh" }, { "sim":52.0, - "partner":"3qur" + "partner":"3d40" }, { "sim":52.0, - "partner":"3qvh" + "partner":"3d41" }, { "sim":52.0, - "partner":"3d40" + "partner":"3qun" }, { "sim":52.0, - "partner":"3d41" + "partner":"3quo" }, { "sim":52.0, - "partner":"3qun" + "partner":"3qvf" }, { "sim":52.0, @@ -686118,11 +688949,11 @@ }, { "sim":52.0, - "partner":"5okt" + "partner":"7nzy" }, { "sim":52.0, - "partner":"7nzy" + "partner":"5okt" }, { "sim":52.0, @@ -686222,15 +689053,15 @@ }, { "sim":52.0, - "partner":"5zkj" + "partner":"6iid" }, { "sim":52.0, - "partner":"6iid" + "partner":"5zki" }, { "sim":52.0, - "partner":"5zki" + "partner":"5zkj" }, { "sim":52.0, @@ -686284,17 +689115,13 @@ "sim":52.0, "partner":"5cee" }, - { - "sim":52.0, - "partner":"2gqn" - }, { "sim":52.0, "partner":"2fq6" }, { "sim":52.0, - "partner":"4lre" + "partner":"2gqn" }, { "sim":52.0, @@ -686312,6 +689139,10 @@ "sim":52.0, "partner":"4lrc" }, + { + "sim":52.0, + "partner":"4lre" + }, { "sim":52.0, "partner":"4c2j" @@ -686326,15 +689157,15 @@ }, { "sim":52.0, - "partner":"5dvi" + "partner":"5dvj" }, { "sim":52.0, - "partner":"5dvj" + "partner":"5dvf" }, { "sim":52.0, - "partner":"5dvf" + "partner":"5dvi" }, { "sim":52.0, @@ -686418,11 +689249,11 @@ }, { "sim":52.0, - "partner":"1zdl" + "partner":"1zkq" }, { "sim":52.0, - "partner":"1zkq" + "partner":"1zdl" }, { "sim":52.0, @@ -686544,10 +689375,6 @@ "sim":52.0, "partner":"6vxe" }, - { - "sim":52.0, - "partner":"6jr8" - }, { "sim":52.0, "partner":"6jr6" @@ -686558,7 +689385,7 @@ }, { "sim":52.0, - "partner":"6yt0" + "partner":"6jr8" }, { "sim":52.0, @@ -686576,6 +689403,10 @@ "sim":52.0, "partner":"6ytj" }, + { + "sim":52.0, + "partner":"6yt0" + }, { "sim":51.0, "partner":"2lo4" @@ -686644,10 +689475,6 @@ "sim":51.0, "partner":"1te4" }, - { - "sim":51.0, - "partner":"4hmr" - }, { "sim":51.0, "partner":"7u0u" @@ -686662,11 +689489,11 @@ }, { "sim":51.0, - "partner":"2i39" + "partner":"4hmr" }, { "sim":51.0, - "partner":"3qna" + "partner":"2i39" }, { "sim":51.0, @@ -686680,6 +689507,10 @@ "sim":51.0, "partner":"3qn9" }, + { + "sim":51.0, + "partner":"3qna" + }, { "sim":51.0, "partner":"3urg" @@ -686700,17 +689531,13 @@ "sim":51.0, "partner":"4tns" }, - { - "sim":51.0, - "partner":"3d7j" - }, { "sim":51.0, "partner":"4gx7" }, { "sim":51.0, - "partner":"3n39" + "partner":"3d7j" }, { "sim":51.0, @@ -686726,7 +689553,7 @@ }, { "sim":51.0, - "partner":"5hso" + "partner":"3n39" }, { "sim":51.0, @@ -686746,7 +689573,7 @@ }, { "sim":51.0, - "partner":"6ebc" + "partner":"5hso" }, { "sim":51.0, @@ -686762,7 +689589,7 @@ }, { "sim":51.0, - "partner":"3sw1" + "partner":"6ebc" }, { "sim":51.0, @@ -686776,13 +689603,17 @@ "sim":51.0, "partner":"5j4e" }, + { + "sim":51.0, + "partner":"6gg9" + }, { "sim":51.0, "partner":"7r4s" }, { "sim":51.0, - "partner":"6gg9" + "partner":"3sw1" }, { "sim":51.0, @@ -686798,11 +689629,11 @@ }, { "sim":51.0, - "partner":"5aoz" + "partner":"6o20" }, { "sim":51.0, - "partner":"6o20" + "partner":"5aoz" }, { "sim":51.0, @@ -686810,11 +689641,11 @@ }, { "sim":51.0, - "partner":"7xtl" + "partner":"3l20" }, { "sim":51.0, - "partner":"3l20" + "partner":"7xtl" }, { "sim":51.0, @@ -686822,15 +689653,15 @@ }, { "sim":51.0, - "partner":"5k24" + "partner":"5t0z" }, { "sim":51.0, - "partner":"5t0z" + "partner":"5k22" }, { "sim":51.0, - "partner":"5k22" + "partner":"5k24" }, { "sim":51.0, @@ -686858,11 +689689,11 @@ }, { "sim":51.0, - "partner":"6f3z" + "partner":"6fhm" }, { "sim":51.0, - "partner":"6fhm" + "partner":"6f3z" }, { "sim":51.0, @@ -686878,15 +689709,11 @@ }, { "sim":51.0, - "partner":"6pj9" - }, - { - "sim":51.0, - "partner":"6pja" + "partner":"6pjp" }, { "sim":51.0, - "partner":"6pjp" + "partner":"6pjq" }, { "sim":51.0, @@ -686894,11 +689721,11 @@ }, { "sim":51.0, - "partner":"6pjq" + "partner":"6pjr" }, { "sim":51.0, - "partner":"6pjr" + "partner":"6pju" }, { "sim":51.0, @@ -686908,10 +689735,6 @@ "sim":51.0, "partner":"5f5d" }, - { - "sim":51.0, - "partner":"6pju" - }, { "sim":51.0, "partner":"4njp" @@ -686934,15 +689757,19 @@ }, { "sim":51.0, - "partner":"5f5j" + "partner":"6pj5" }, { "sim":51.0, - "partner":"6pj5" + "partner":"6pj7" }, { "sim":51.0, - "partner":"6pj7" + "partner":"5f5j" + }, + { + "sim":51.0, + "partner":"6pj8" }, { "sim":51.0, @@ -686950,7 +689777,11 @@ }, { "sim":51.0, - "partner":"6pj8" + "partner":"6pj9" + }, + { + "sim":51.0, + "partner":"6pja" }, { "sim":51.0, @@ -686970,11 +689801,11 @@ }, { "sim":51.0, - "partner":"6nko" + "partner":"4oki" }, { "sim":51.0, - "partner":"4oki" + "partner":"6nko" }, { "sim":51.0, @@ -687034,23 +689865,23 @@ }, { "sim":51.0, - "partner":"8vip" + "partner":"8vit" }, { "sim":51.0, - "partner":"8viq" + "partner":"2xx3" }, { "sim":51.0, - "partner":"8vir" + "partner":"8vip" }, { "sim":51.0, - "partner":"8vit" + "partner":"8viq" }, { "sim":51.0, - "partner":"2xx3" + "partner":"8vir" }, { "sim":51.0, @@ -687078,16 +689909,12 @@ }, { "sim":51.0, - "partner":"7o2t" + "partner":"6z17" }, { "sim":51.0, "partner":"7o2u" }, - { - "sim":51.0, - "partner":"6z17" - }, { "sim":51.0, "partner":"6yz3" @@ -687104,6 +689931,10 @@ "sim":51.0, "partner":"6z5k" }, + { + "sim":51.0, + "partner":"7o2t" + }, { "sim":51.0, "partner":"2whs" @@ -687194,11 +690025,11 @@ }, { "sim":51.0, - "partner":"5du6" + "partner":"2ouk" }, { "sim":51.0, - "partner":"2ouk" + "partner":"5du6" }, { "sim":51.0, @@ -687260,10 +690091,6 @@ "sim":51.0, "partner":"3kmr" }, - { - "sim":51.0, - "partner":"4jyi" - }, { "sim":51.0, "partner":"4dm6" @@ -687290,19 +690117,11 @@ }, { "sim":51.0, - "partner":"4qts" - }, - { - "sim":51.0, - "partner":"6ub4" - }, - { - "sim":51.0, - "partner":"6ub5" + "partner":"4jyi" }, { "sim":51.0, - "partner":"6ub6" + "partner":"4qts" }, { "sim":51.0, @@ -687318,15 +690137,15 @@ }, { "sim":51.0, - "partner":"5ds3" + "partner":"6ub4" }, { "sim":51.0, - "partner":"6bhv" + "partner":"6ub5" }, { "sim":51.0, - "partner":"1z5z" + "partner":"6ub6" }, { "sim":51.0, @@ -687356,6 +690175,18 @@ "sim":51.0, "partner":"6nrj" }, + { + "sim":51.0, + "partner":"6bhv" + }, + { + "sim":51.0, + "partner":"5ds3" + }, + { + "sim":51.0, + "partner":"1z5z" + }, { "sim":51.0, "partner":"1yb2" @@ -687410,24 +690241,12 @@ }, { "sim":51.0, - "partner":"5coq" - }, - { - "sim":51.0, - "partner":"5cpb" - }, - { - "sim":51.0, - "partner":"5mtr" + "partner":"4oxk" }, { "sim":51.0, "partner":"5ugt" }, - { - "sim":51.0, - "partner":"4oxk" - }, { "sim":51.0, "partner":"5ugu" @@ -687438,15 +690257,15 @@ }, { "sim":51.0, - "partner":"4oxn" + "partner":"6yuu" }, { "sim":51.0, - "partner":"4oyr" + "partner":"4oxn" }, { "sim":51.0, - "partner":"6yuu" + "partner":"4oyr" }, { "sim":51.0, @@ -687472,10 +690291,22 @@ "sim":51.0, "partner":"5cp8" }, + { + "sim":51.0, + "partner":"5mtr" + }, { "sim":51.0, "partner":"5ugs" }, + { + "sim":51.0, + "partner":"5cpb" + }, + { + "sim":51.0, + "partner":"5coq" + }, { "sim":51.0, "partner":"6y98" @@ -687506,11 +690337,11 @@ }, { "sim":51.0, - "partner":"1xhl" + "partner":"6p7g" }, { "sim":51.0, - "partner":"6p7g" + "partner":"1xhl" }, { "sim":51.0, @@ -687532,10 +690363,6 @@ "sim":51.0, "partner":"6unv" }, - { - "sim":51.0, - "partner":"3s3h" - }, { "sim":51.0, "partner":"3s3k" @@ -687550,7 +690377,7 @@ }, { "sim":51.0, - "partner":"7xif" + "partner":"3s3h" }, { "sim":51.0, @@ -687566,19 +690393,19 @@ }, { "sim":51.0, - "partner":"6zhl" + "partner":"7xif" }, { "sim":51.0, - "partner":"6zhm" + "partner":"6zhl" }, { "sim":51.0, - "partner":"6zjo" + "partner":"6zhm" }, { "sim":51.0, - "partner":"3g3d" + "partner":"6zjo" }, { "sim":51.0, @@ -687596,6 +690423,10 @@ "sim":51.0, "partner":"4hkp" }, + { + "sim":51.0, + "partner":"3g3d" + }, { "sim":51.0, "partner":"7e4m" @@ -687704,10 +690535,6 @@ "sim":51.0, "partner":"5v8y" }, - { - "sim":51.0, - "partner":"5jyf" - }, { "sim":51.0, "partner":"5v8x" @@ -687746,11 +690573,11 @@ }, { "sim":51.0, - "partner":"3ly2" + "partner":"5jyf" }, { "sim":51.0, - "partner":"1vsu" + "partner":"3ly2" }, { "sim":51.0, @@ -687764,6 +690591,10 @@ "sim":51.0, "partner":"5eqn" }, + { + "sim":51.0, + "partner":"1vsu" + }, { "sim":51.0, "partner":"6nor" @@ -687792,10 +690623,6 @@ "sim":51.0, "partner":"5c2h" }, - { - "sim":51.0, - "partner":"4m1i" - }, { "sim":51.0, "partner":"4aub" @@ -687812,6 +690639,10 @@ "sim":51.0, "partner":"4m1h" }, + { + "sim":51.0, + "partner":"4m1i" + }, { "sim":51.0, "partner":"6eow" @@ -687830,23 +690661,23 @@ }, { "sim":51.0, - "partner":"6vkk" + "partner":"6rfo" }, { "sim":51.0, - "partner":"6vkq" + "partner":"6vko" }, { "sim":51.0, - "partner":"6rfo" + "partner":"4myg" }, { "sim":51.0, - "partner":"6vko" + "partner":"6vkk" }, { "sim":51.0, - "partner":"4myg" + "partner":"6vkq" }, { "sim":51.0, @@ -687896,10 +690727,6 @@ "sim":51.0, "partner":"4rzt" }, - { - "sim":51.0, - "partner":"3pz9" - }, { "sim":51.0, "partner":"3pzg" @@ -687930,7 +690757,7 @@ }, { "sim":51.0, - "partner":"6ojx" + "partner":"3pz9" }, { "sim":51.0, @@ -687962,16 +690789,20 @@ }, { "sim":51.0, - "partner":"7dmb" + "partner":"6ojx" }, { "sim":51.0, - "partner":"8bao" + "partner":"7dmb" }, { "sim":51.0, "partner":"5j8x" }, + { + "sim":51.0, + "partner":"8bao" + }, { "sim":51.0, "partner":"5tzb" @@ -687988,10 +690819,6 @@ "sim":51.0, "partner":"3bu7" }, - { - "sim":51.0, - "partner":"1xm6" - }, { "sim":51.0, "partner":"1xos" @@ -688036,6 +690863,10 @@ "sim":51.0, "partner":"1xn0" }, + { + "sim":51.0, + "partner":"1xm6" + }, { "sim":51.0, "partner":"4ak5" @@ -688352,10 +691183,6 @@ "sim":51.0, "partner":"1rh0" }, - { - "sim":51.0, - "partner":"6rk2" - }, { "sim":51.0, "partner":"6rjo" @@ -688370,19 +691197,19 @@ }, { "sim":51.0, - "partner":"6jmw" + "partner":"6rk2" }, { "sim":51.0, - "partner":"6jzs" + "partner":"6jmw" }, { "sim":51.0, - "partner":"5l77" + "partner":"6jzs" }, { "sim":51.0, - "partner":"6pt4" + "partner":"5l77" }, { "sim":51.0, @@ -688396,6 +691223,10 @@ "sim":51.0, "partner":"6ptk" }, + { + "sim":51.0, + "partner":"6pt4" + }, { "sim":51.0, "partner":"6rim" @@ -688468,10 +691299,6 @@ "sim":51.0, "partner":"7all" }, - { - "sim":51.0, - "partner":"3qp9" - }, { "sim":51.0, "partner":"3sur" @@ -688508,6 +691335,10 @@ "sim":51.0, "partner":"3gh7" }, + { + "sim":51.0, + "partner":"3qp9" + }, { "sim":51.0, "partner":"3u9s" @@ -688526,27 +691357,27 @@ }, { "sim":51.0, - "partner":"4ids" + "partner":"4lem" }, { "sim":51.0, - "partner":"4jdc" + "partner":"4idm" }, { "sim":51.0, - "partner":"4lem" + "partner":"4ns3" }, { "sim":51.0, - "partner":"4idm" + "partner":"4ihi" }, { "sim":51.0, - "partner":"4ns3" + "partner":"4ids" }, { "sim":51.0, - "partner":"4ihi" + "partner":"4jdc" }, { "sim":51.0, @@ -688574,11 +691405,11 @@ }, { "sim":51.0, - "partner":"7jwf" + "partner":"7jw4" }, { "sim":51.0, - "partner":"7jw4" + "partner":"7jwf" }, { "sim":51.0, @@ -688592,10 +691423,6 @@ "sim":51.0, "partner":"3tj1" }, - { - "sim":51.0, - "partner":"3o8y" - }, { "sim":51.0, "partner":"7ttj" @@ -688626,7 +691453,7 @@ }, { "sim":51.0, - "partner":"6k8s" + "partner":"3o8y" }, { "sim":51.0, @@ -688638,15 +691465,15 @@ }, { "sim":51.0, - "partner":"5x7g" + "partner":"6k8s" }, { "sim":51.0, - "partner":"5x7h" + "partner":"5x7g" }, { "sim":51.0, - "partner":"6edw" + "partner":"5x7h" }, { "sim":51.0, @@ -688658,15 +691485,11 @@ }, { "sim":51.0, - "partner":"3slk" - }, - { - "sim":51.0, - "partner":"4j3t" + "partner":"6edw" }, { "sim":51.0, - "partner":"4j3u" + "partner":"3slk" }, { "sim":51.0, @@ -688686,7 +691509,11 @@ }, { "sim":51.0, - "partner":"5y1h" + "partner":"4j3t" + }, + { + "sim":51.0, + "partner":"4j3u" }, { "sim":51.0, @@ -688732,6 +691559,10 @@ "sim":51.0, "partner":"5y3i" }, + { + "sim":51.0, + "partner":"5y1h" + }, { "sim":51.0, "partner":"5wmm" @@ -688930,11 +691761,11 @@ }, { "sim":50.0, - "partner":"2wja" + "partner":"7a6p" }, { "sim":50.0, - "partner":"7a6p" + "partner":"2wja" }, { "sim":50.0, @@ -688990,11 +691821,11 @@ }, { "sim":50.0, - "partner":"6uv7" + "partner":"6uvi" }, { "sim":50.0, - "partner":"6uvi" + "partner":"6uv7" }, { "sim":50.0, @@ -689034,11 +691865,11 @@ }, { "sim":50.0, - "partner":"7u4l" + "partner":"6elw" }, { "sim":50.0, - "partner":"6elw" + "partner":"7u4l" }, { "sim":50.0, @@ -689094,23 +691925,19 @@ }, { "sim":50.0, - "partner":"3th5" - }, - { - "sim":50.0, - "partner":"4c76" + "partner":"4gzl" }, { "sim":50.0, - "partner":"4gzl" + "partner":"4gzm" }, { "sim":50.0, - "partner":"4gzm" + "partner":"3th5" }, { "sim":50.0, - "partner":"3l1u" + "partner":"4c76" }, { "sim":50.0, @@ -689128,6 +691955,10 @@ "sim":50.0, "partner":"3esr" }, + { + "sim":50.0, + "partner":"3l1u" + }, { "sim":50.0, "partner":"2l22" @@ -689152,10 +691983,6 @@ "sim":50.0, "partner":"5f51" }, - { - "sim":50.0, - "partner":"6j0l" - }, { "sim":50.0, "partner":"6j0g" @@ -689168,6 +691995,10 @@ "sim":50.0, "partner":"6j0k" }, + { + "sim":50.0, + "partner":"6j0l" + }, { "sim":50.0, "partner":"6ttr" @@ -689190,31 +692021,31 @@ }, { "sim":50.0, - "partner":"7mnq" + "partner":"7mns" }, { "sim":50.0, - "partner":"7mnr" + "partner":"7mnt" }, { "sim":50.0, - "partner":"7mns" + "partner":"4irb" }, { "sim":50.0, - "partner":"4irb" + "partner":"7mnu" }, { "sim":50.0, - "partner":"7mnt" + "partner":"7mnv" }, { "sim":50.0, - "partner":"7mnu" + "partner":"7mnq" }, { "sim":50.0, - "partner":"7mnv" + "partner":"7mnr" }, { "sim":50.0, @@ -689248,10 +692079,6 @@ "sim":50.0, "partner":"6w6b" }, - { - "sim":50.0, - "partner":"3la7" - }, { "sim":50.0, "partner":"3la2" @@ -689262,11 +692089,7 @@ }, { "sim":50.0, - "partner":"4bmx" - }, - { - "sim":50.0, - "partner":"4bmy" + "partner":"3la7" }, { "sim":50.0, @@ -689282,7 +692105,11 @@ }, { "sim":50.0, - "partner":"4da6" + "partner":"4bmx" + }, + { + "sim":50.0, + "partner":"4bmy" }, { "sim":50.0, @@ -689338,12 +692165,16 @@ }, { "sim":50.0, - "partner":"4dg7" + "partner":"4da6" }, { "sim":50.0, "partner":"2vh2" }, + { + "sim":50.0, + "partner":"4dg7" + }, { "sim":50.0, "partner":"2va1" @@ -689368,10 +692199,6 @@ "sim":50.0, "partner":"3hs9" }, - { - "sim":50.0, - "partner":"3vms" - }, { "sim":50.0, "partner":"3vmt" @@ -689384,6 +692211,10 @@ "sim":50.0, "partner":"3vmr" }, + { + "sim":50.0, + "partner":"3vms" + }, { "sim":50.0, "partner":"3nok" @@ -689428,10 +692259,6 @@ "sim":50.0, "partner":"3uic" }, - { - "sim":50.0, - "partner":"4j3f" - }, { "sim":50.0, "partner":"3p8x" @@ -689450,7 +692277,7 @@ }, { "sim":50.0, - "partner":"4fq7" + "partner":"4j3f" }, { "sim":50.0, @@ -689458,27 +692285,31 @@ }, { "sim":50.0, - "partner":"4jqc" + "partner":"4fq7" }, { "sim":50.0, - "partner":"6t2p" + "partner":"6t2o" }, { "sim":50.0, - "partner":"2wk1" + "partner":"4jx8" }, { "sim":50.0, - "partner":"6t2q" + "partner":"6t2p" }, { "sim":50.0, - "partner":"4jx8" + "partner":"4jqc" }, { "sim":50.0, - "partner":"6t2o" + "partner":"6t2q" + }, + { + "sim":50.0, + "partner":"2wk1" }, { "sim":50.0, @@ -689498,19 +692329,19 @@ }, { "sim":50.0, - "partner":"7a61" + "partner":"8rwq" }, { "sim":50.0, - "partner":"5uj3" + "partner":"6mnp" }, { "sim":50.0, - "partner":"5uj4" + "partner":"8rwr" }, { "sim":50.0, - "partner":"6mnp" + "partner":"5uj3" }, { "sim":50.0, @@ -689518,7 +692349,11 @@ }, { "sim":50.0, - "partner":"5ul8" + "partner":"8rws" + }, + { + "sim":50.0, + "partner":"5uj4" }, { "sim":50.0, @@ -689534,11 +692369,11 @@ }, { "sim":50.0, - "partner":"6d18" + "partner":"5ul8" }, { "sim":50.0, - "partner":"5zz3" + "partner":"6d18" }, { "sim":50.0, @@ -689552,6 +692387,10 @@ "sim":50.0, "partner":"6z21" }, + { + "sim":50.0, + "partner":"5zz3" + }, { "sim":50.0, "partner":"6qwa" @@ -689576,10 +692415,6 @@ "sim":50.0, "partner":"6z24" }, - { - "sim":50.0, - "partner":"4o0q" - }, { "sim":50.0, "partner":"6qwd" @@ -689594,7 +692429,7 @@ }, { "sim":50.0, - "partner":"8rwq" + "partner":"4o0q" }, { "sim":50.0, @@ -689608,10 +692443,6 @@ "sim":50.0, "partner":"6v7i" }, - { - "sim":50.0, - "partner":"4o1e" - }, { "sim":50.0, "partner":"6m7i" @@ -689624,10 +692455,26 @@ "sim":50.0, "partner":"6td1" }, + { + "sim":50.0, + "partner":"4o1e" + }, { "sim":50.0, "partner":"4o1f" }, + { + "sim":50.0, + "partner":"7a61" + }, + { + "sim":50.0, + "partner":"8rwo" + }, + { + "sim":50.0, + "partner":"8rwp" + }, { "sim":50.0, "partner":"3et1" @@ -689670,11 +692517,11 @@ }, { "sim":50.0, - "partner":"5lsg" + "partner":"6t9c" }, { "sim":50.0, - "partner":"6t9c" + "partner":"5lsg" }, { "sim":50.0, @@ -689742,11 +692589,11 @@ }, { "sim":50.0, - "partner":"6lcn" + "partner":"7x1l" }, { "sim":50.0, - "partner":"7x1l" + "partner":"6lcn" }, { "sim":50.0, @@ -689880,18 +692727,6 @@ "sim":50.0, "partner":"4ilk" }, - { - "sim":50.0, - "partner":"4m25" - }, - { - "sim":50.0, - "partner":"4m2i" - }, - { - "sim":50.0, - "partner":"4ne0" - }, { "sim":50.0, "partner":"4m26" @@ -689928,6 +692763,18 @@ "sim":50.0, "partner":"4m2g" }, + { + "sim":50.0, + "partner":"4m25" + }, + { + "sim":50.0, + "partner":"4m2i" + }, + { + "sim":50.0, + "partner":"4ne0" + }, { "sim":50.0, "partner":"3wcg" @@ -690014,31 +692861,31 @@ }, { "sim":50.0, - "partner":"6zgp" + "partner":"6y9d" }, { "sim":50.0, - "partner":"6y8j" + "partner":"6zgp" }, { "sim":50.0, - "partner":"6y9c" + "partner":"2qap" }, { "sim":50.0, - "partner":"6y9d" + "partner":"6y8s" }, { "sim":50.0, - "partner":"2qap" + "partner":"2qdg" }, { "sim":50.0, - "partner":"6y8s" + "partner":"6y8j" }, { "sim":50.0, - "partner":"2qdg" + "partner":"6y9c" }, { "sim":50.0, @@ -690114,15 +692961,15 @@ }, { "sim":50.0, - "partner":"4gpu" + "partner":"5u22" }, { "sim":50.0, - "partner":"5u22" + "partner":"4gps" }, { "sim":50.0, - "partner":"4gps" + "partner":"4gpu" }, { "sim":50.0, @@ -690146,15 +692993,15 @@ }, { "sim":50.0, - "partner":"5z8a" + "partner":"5z8k" }, { "sim":50.0, - "partner":"5z8k" + "partner":"5z83" }, { "sim":50.0, - "partner":"5z83" + "partner":"5z8a" }, { "sim":50.0, @@ -690240,10 +693087,6 @@ "sim":50.0, "partner":"6qps" }, - { - "sim":50.0, - "partner":"2wc4" - }, { "sim":50.0, "partner":"1oif" @@ -690356,6 +693199,10 @@ "sim":50.0, "partner":"1uz1" }, + { + "sim":50.0, + "partner":"2wc4" + }, { "sim":50.0, "partner":"6j0u" @@ -690410,24 +693257,20 @@ }, { "sim":50.0, - "partner":"6gcn" + "partner":"5kqw" }, { "sim":50.0, - "partner":"6gco" + "partner":"6gcn" }, { "sim":50.0, - "partner":"5kqw" + "partner":"6gco" }, { "sim":50.0, "partner":"4ife" }, - { - "sim":50.0, - "partner":"5uno" - }, { "sim":50.0, "partner":"7m7c" @@ -690446,11 +693289,11 @@ }, { "sim":50.0, - "partner":"4l6w" + "partner":"5uno" }, { "sim":50.0, - "partner":"6x0h" + "partner":"4l6w" }, { "sim":50.0, @@ -690460,6 +693303,10 @@ "sim":50.0, "partner":"6x0k" }, + { + "sim":50.0, + "partner":"6x0h" + }, { "sim":50.0, "partner":"5kky" @@ -690490,11 +693337,11 @@ }, { "sim":50.0, - "partner":"7an1" + "partner":"7oqd" }, { "sim":50.0, - "partner":"7oqd" + "partner":"7an1" }, { "sim":50.0, @@ -690508,10 +693355,6 @@ "sim":50.0, "partner":"5m1e" }, - { - "sim":50.0, - "partner":"2cj9" - }, { "sim":50.0, "partner":"2cja" @@ -690524,6 +693367,10 @@ "sim":50.0, "partner":"2cjb" }, + { + "sim":50.0, + "partner":"2cj9" + }, { "sim":50.0, "partner":"6yyh" @@ -690698,15 +693545,15 @@ }, { "sim":50.0, - "partner":"7w1c" + "partner":"7w1d" }, { "sim":50.0, - "partner":"7w1d" + "partner":"7w1e" }, { "sim":50.0, - "partner":"7w1e" + "partner":"7w1c" }, { "sim":50.0, @@ -690720,10 +693567,6 @@ "sim":50.0, "partner":"4put" }, - { - "sim":50.0, - "partner":"7wlg" - }, { "sim":50.0, "partner":"7wj9" @@ -690754,7 +693597,7 @@ }, { "sim":50.0, - "partner":"6r5p" + "partner":"7wlg" }, { "sim":50.0, @@ -690772,6 +693615,10 @@ "sim":50.0, "partner":"2wco" }, + { + "sim":50.0, + "partner":"6r5p" + }, { "sim":50.0, "partner":"3zvr" @@ -690802,35 +693649,35 @@ }, { "sim":50.0, - "partner":"3ahc" + "partner":"3ahf" }, { "sim":50.0, - "partner":"3ahd" + "partner":"3ahg" }, { "sim":50.0, - "partner":"3ahe" + "partner":"3ahh" }, { "sim":50.0, - "partner":"3ahf" + "partner":"3ahi" }, { "sim":50.0, - "partner":"3ahg" + "partner":"3ahj" }, { "sim":50.0, - "partner":"3ahh" + "partner":"3ahc" }, { "sim":50.0, - "partner":"3ahi" + "partner":"3ahd" }, { "sim":50.0, - "partner":"3ahj" + "partner":"3ahe" } ], "struct_thr_sim_designed":[ @@ -690907,75 +693754,75 @@ ], "subtitle":"De novo design cavitated protein without predefined topology", "tags":[ - "cavitated protein", "de novo protein", + "cavitated protein", "de novo design" ], "keywords":[ - "great", + "designed", + "designing", + "introducing", + "naturally", + "design", + "sampling", + "energy", + "cavities", + "backbones", + "521", + "one", + "indicate", + "tailored", "diverse", - "statistical", + "methods", + "structures", + "hold", + "de", + "efforts", + "rmsds", + "agreement", + "dimer", + "experimentally", + "side", + "based", + "potential", + "\u00e5", + "tested", "without", - "architectures", - "restraints", - "designs", - "deviations", + "c\u03b1", "predefined", - "arrangement", - "tested", - "tailored", + "atoms", + "deviations", + "within", + "partial", + "results", + "determined", + "great", + "driven", + "closely", + "model", + "protein", "network", - "one", + "architectures", + "function", "proteins", - "results", + "neural", "5816", - "de", - "rmsds", + "backbone", + "occurring", "novo", - "efforts", - "driven", - "\u00e5", - "hold", - "designed", - "atoms", - "10", + "agrees", "requires", - "closely", - "dimer", - "agreement", - "521", + "arrangement", + "forms", + "contain", "two", - "experimentally", "crystal", - "methods", - "occurring", - "determined", - "potential", - "based", - "design", - "sampling", - "model", - "partial", - "structures", - "protein", - "naturally", + "designs", "scuba", + "10", + "restraints", "previous", - "backbone", - "agrees", - "designing", - "c\u03b1", - "neural", - "cavities", - "function", - "indicate", - "energy", - "within", - "introducing", - "side", - "backbones", - "forms", - "contain" + "statistical" ], "release_date":"2023-01-18", "publication":"\"De novo design of cavity-containing proteins with a backbone-centered neural network energy function\", Structure, 32, 424", @@ -691012,11 +693859,11 @@ }, { "sim":90.0, - "partner":"8j1x" + "partner":"8j98" }, { "sim":90.0, - "partner":"8j98" + "partner":"8j1x" }, { "sim":90.0, @@ -691028,11 +693875,11 @@ }, { "sim":57.0, - "partner":"8v2w" + "partner":"8v09" }, { "sim":57.0, - "partner":"8v09" + "partner":"8v2w" }, { "sim":55.0, @@ -691040,15 +693887,15 @@ }, { "sim":55.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":55.0, - "partner":"8w05" + "partner":"8w06" }, { "sim":54.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":54.0, @@ -691056,7 +693903,7 @@ }, { "sim":54.0, - "partner":"8w08" + "partner":"8v0a" }, { "sim":53.0, @@ -691116,10 +693963,6 @@ "sim":76.0, "partner":"5gv1" }, - { - "sim":76.0, - "partner":"7dw8" - }, { "sim":76.0, "partner":"7dwa" @@ -691136,6 +693979,10 @@ "sim":76.0, "partner":"7dvj" }, + { + "sim":76.0, + "partner":"7dw8" + }, { "sim":76.0, "partner":"7dkg" @@ -691180,18 +694027,6 @@ "sim":74.0, "partner":"3l9f" }, - { - "sim":74.0, - "partner":"7ex2" - }, - { - "sim":74.0, - "partner":"7ex3" - }, - { - "sim":74.0, - "partner":"7ex4" - }, { "sim":74.0, "partner":"7ex6" @@ -691240,6 +694075,18 @@ "sim":74.0, "partner":"7ex1" }, + { + "sim":74.0, + "partner":"7ex2" + }, + { + "sim":74.0, + "partner":"7ex3" + }, + { + "sim":74.0, + "partner":"7ex4" + }, { "sim":74.0, "partner":"3l87" @@ -691354,11 +694201,11 @@ }, { "sim":73.0, - "partner":"3la8" + "partner":"3lba" }, { "sim":73.0, - "partner":"3lba" + "partner":"3la8" }, { "sim":73.0, @@ -691408,10 +694255,6 @@ "sim":73.0, "partner":"5c1t" }, - { - "sim":73.0, - "partner":"6jtl" - }, { "sim":73.0, "partner":"6jti" @@ -691424,6 +694267,10 @@ "sim":73.0, "partner":"6jtk" }, + { + "sim":73.0, + "partner":"6jtl" + }, { "sim":73.0, "partner":"3psp" @@ -691468,10 +694315,6 @@ "sim":72.0, "partner":"2kxn" }, - { - "sim":72.0, - "partner":"3ul6" - }, { "sim":72.0, "partner":"2kg1" @@ -691486,16 +694329,20 @@ }, { "sim":72.0, - "partner":"4qpj" + "partner":"3ul6" }, { "sim":72.0, - "partner":"6isk" + "partner":"4qpj" }, { "sim":72.0, "partner":"6isl" }, + { + "sim":72.0, + "partner":"6isk" + }, { "sim":72.0, "partner":"4egs" @@ -691556,10 +694403,6 @@ "sim":72.0, "partner":"3wg8" }, - { - "sim":72.0, - "partner":"2uxx" - }, { "sim":72.0, "partner":"2iw5" @@ -691572,6 +694415,10 @@ "sim":72.0, "partner":"4kum" }, + { + "sim":72.0, + "partner":"2uxx" + }, { "sim":72.0, "partner":"7vxo" @@ -691698,27 +694545,27 @@ }, { "sim":72.0, - "partner":"6alm" + "partner":"6alo" }, { "sim":72.0, - "partner":"6aln" + "partner":"6alp" }, { "sim":72.0, - "partner":"6alo" + "partner":"6alq" }, { "sim":72.0, - "partner":"6alp" + "partner":"6alr" }, { "sim":72.0, - "partner":"6alq" + "partner":"6alm" }, { "sim":72.0, - "partner":"6alr" + "partner":"6aln" }, { "sim":72.0, @@ -691728,10 +694575,6 @@ "sim":72.0, "partner":"4irn" }, - { - "sim":72.0, - "partner":"3pln" - }, { "sim":72.0, "partner":"3phl" @@ -691746,15 +694589,15 @@ }, { "sim":72.0, - "partner":"3pid" + "partner":"3pln" }, { "sim":72.0, - "partner":"5ex6" + "partner":"3pid" }, { "sim":72.0, - "partner":"3nc3" + "partner":"5ex6" }, { "sim":72.0, @@ -691768,6 +694611,10 @@ "sim":72.0, "partner":"3nc7" }, + { + "sim":72.0, + "partner":"3nc3" + }, { "sim":72.0, "partner":"4lyp" @@ -691790,11 +694637,11 @@ }, { "sim":72.0, - "partner":"4nxl" + "partner":"4jek" }, { "sim":72.0, - "partner":"4jek" + "partner":"4nxl" }, { "sim":72.0, @@ -691822,28 +694669,20 @@ }, { "sim":72.0, - "partner":"6unz" - }, - { - "sim":72.0, - "partner":"6uoj" + "partner":"6msn" }, { "sim":72.0, - "partner":"6upo" + "partner":"6unz" }, { "sim":72.0, - "partner":"6msn" + "partner":"6uq8" }, { "sim":72.0, "partner":"5l2r" }, - { - "sim":72.0, - "partner":"6uq8" - }, { "sim":72.0, "partner":"6uo0" @@ -691880,6 +694719,26 @@ "sim":72.0, "partner":"6up9" }, + { + "sim":72.0, + "partner":"6uoj" + }, + { + "sim":72.0, + "partner":"6upo" + }, + { + "sim":72.0, + "partner":"8vjq" + }, + { + "sim":72.0, + "partner":"8vix" + }, + { + "sim":72.0, + "partner":"8vh0" + }, { "sim":72.0, "partner":"4zci" @@ -691970,11 +694829,11 @@ }, { "sim":71.0, - "partner":"6mwy" + "partner":"6myl" }, { "sim":71.0, - "partner":"6myl" + "partner":"6mwy" }, { "sim":71.0, @@ -691994,11 +694853,11 @@ }, { "sim":71.0, - "partner":"5feu" + "partner":"6y4d" }, { "sim":71.0, - "partner":"6y4d" + "partner":"5feu" }, { "sim":71.0, @@ -692218,11 +695077,11 @@ }, { "sim":70.0, - "partner":"5nbt" + "partner":"6gzc" }, { "sim":70.0, - "partner":"6gzc" + "partner":"5nbt" }, { "sim":70.0, @@ -692252,10 +695111,6 @@ "sim":70.0, "partner":"4nod" }, - { - "sim":70.0, - "partner":"5nbh" - }, { "sim":70.0, "partner":"5n8d" @@ -692268,6 +695123,10 @@ "sim":70.0, "partner":"5n83" }, + { + "sim":70.0, + "partner":"5nbh" + }, { "sim":70.0, "partner":"4qpk" @@ -692302,11 +695161,11 @@ }, { "sim":70.0, - "partner":"6pei" + "partner":"6pej" }, { "sim":70.0, - "partner":"6pej" + "partner":"6pei" }, { "sim":70.0, @@ -692344,10 +695203,6 @@ "sim":70.0, "partner":"6dj6" }, - { - "sim":70.0, - "partner":"5yoi" - }, { "sim":70.0, "partner":"5ypj" @@ -692364,6 +695219,10 @@ "sim":70.0, "partner":"5yoh" }, + { + "sim":70.0, + "partner":"5yoi" + }, { "sim":70.0, "partner":"3pl5" @@ -692406,15 +695265,11 @@ }, { "sim":70.0, - "partner":"7cm8" - }, - { - "sim":70.0, - "partner":"7djq" + "partner":"7c35" }, { "sim":70.0, - "partner":"7c35" + "partner":"7ewo" }, { "sim":70.0, @@ -692430,7 +695285,7 @@ }, { "sim":70.0, - "partner":"7ewo" + "partner":"7cm8" }, { "sim":70.0, @@ -692438,11 +695293,11 @@ }, { "sim":70.0, - "partner":"7cd5" + "partner":"7djq" }, { "sim":70.0, - "partner":"3tro" + "partner":"7cd5" }, { "sim":70.0, @@ -692452,6 +695307,10 @@ "sim":70.0, "partner":"7myd" }, + { + "sim":70.0, + "partner":"3tro" + }, { "sim":70.0, "partner":"3tn3" @@ -692482,15 +695341,15 @@ }, { "sim":70.0, - "partner":"8uen" + "partner":"8uro" }, { "sim":70.0, - "partner":"8ura" + "partner":"8uen" }, { "sim":70.0, - "partner":"8uro" + "partner":"8ura" }, { "sim":70.0, @@ -692502,23 +695361,23 @@ }, { "sim":70.0, - "partner":"7ffg" + "partner":"7ffi" }, { "sim":70.0, - "partner":"7ffh" + "partner":"7ffa" }, { "sim":70.0, - "partner":"7ffi" + "partner":"7ffc" }, { "sim":70.0, - "partner":"7ffa" + "partner":"7ffg" }, { "sim":70.0, - "partner":"7ffc" + "partner":"7ffh" }, { "sim":70.0, @@ -692574,11 +695433,11 @@ }, { "sim":70.0, - "partner":"3l7r" + "partner":"3t0c" }, { "sim":70.0, - "partner":"3t0c" + "partner":"3l7r" }, { "sim":70.0, @@ -692620,21 +695479,17 @@ "sim":69.0, "partner":"7cys" }, - { - "sim":69.0, - "partner":"7q9z" - }, { "sim":69.0, "partner":"7q9x" }, { "sim":69.0, - "partner":"5e0o" + "partner":"7q9z" }, { "sim":69.0, - "partner":"4bzc" + "partner":"5e0o" }, { "sim":69.0, @@ -692642,16 +695497,12 @@ }, { "sim":69.0, - "partner":"6dwk" + "partner":"6dwd" }, { "sim":69.0, "partner":"4qg2" }, - { - "sim":69.0, - "partner":"6dwd" - }, { "sim":69.0, "partner":"7s2y" @@ -692702,11 +695553,15 @@ }, { "sim":69.0, - "partner":"4e85" + "partner":"6dwk" }, { - "sim":68.0, - "partner":"4d1f" + "sim":69.0, + "partner":"4bzc" + }, + { + "sim":69.0, + "partner":"4e85" }, { "sim":68.0, @@ -692716,6 +695571,10 @@ "sim":68.0, "partner":"4d0u" }, + { + "sim":68.0, + "partner":"4d1f" + }, { "sim":68.0, "partner":"5fld" @@ -692740,10 +695599,6 @@ "sim":68.0, "partner":"5zi0" }, - { - "sim":68.0, - "partner":"2zbb" - }, { "sim":68.0, "partner":"3e4o" @@ -692756,6 +695611,10 @@ "sim":68.0, "partner":"3e4q" }, + { + "sim":68.0, + "partner":"2zbb" + }, { "sim":68.0, "partner":"6nok" @@ -693048,10 +695907,6 @@ "sim":58.0, "partner":"2iss" }, - { - "sim":58.0, - "partner":"3g3d" - }, { "sim":58.0, "partner":"3bvj" @@ -693068,6 +695923,10 @@ "sim":58.0, "partner":"4hkp" }, + { + "sim":58.0, + "partner":"3g3d" + }, { "sim":57.0, "partner":"2lj9" @@ -693114,11 +695973,11 @@ }, { "sim":57.0, - "partner":"4f0v" + "partner":"4f0w" }, { "sim":57.0, - "partner":"4f0w" + "partner":"4f0v" }, { "sim":57.0, @@ -693212,10 +696071,6 @@ "sim":56.0, "partner":"6mhf" }, - { - "sim":56.0, - "partner":"7ajm" - }, { "sim":56.0, "partner":"7a4r" @@ -693230,23 +696085,7 @@ }, { "sim":56.0, - "partner":"7a53" - }, - { - "sim":56.0, - "partner":"7ajw" - }, - { - "sim":56.0, - "partner":"7akb" - }, - { - "sim":56.0, - "partner":"7ajy" - }, - { - "sim":56.0, - "partner":"7a5l" + "partner":"7ajm" }, { "sim":56.0, @@ -693308,17 +696147,33 @@ "sim":56.0, "partner":"7aka" }, + { + "sim":56.0, + "partner":"7a53" + }, { "sim":56.0, "partner":"7akl" }, { "sim":56.0, - "partner":"4rl1" + "partner":"7ajw" }, { "sim":56.0, - "partner":"2cj9" + "partner":"7akb" + }, + { + "sim":56.0, + "partner":"7ajy" + }, + { + "sim":56.0, + "partner":"7a5l" + }, + { + "sim":56.0, + "partner":"4rl1" }, { "sim":56.0, @@ -693332,6 +696187,10 @@ "sim":56.0, "partner":"2cjb" }, + { + "sim":56.0, + "partner":"2cj9" + }, { "sim":56.0, "partner":"6xsx" @@ -693350,15 +696209,15 @@ }, { "sim":56.0, - "partner":"5tsh" + "partner":"6olj" }, { "sim":56.0, - "partner":"6olj" + "partner":"5tsg" }, { "sim":56.0, - "partner":"5tsg" + "partner":"5tsh" }, { "sim":56.0, @@ -693400,10 +696259,6 @@ "sim":55.0, "partner":"4luj" }, - { - "sim":55.0, - "partner":"6o98" - }, { "sim":55.0, "partner":"7jh2" @@ -693418,19 +696273,15 @@ }, { "sim":55.0, - "partner":"2per" - }, - { - "sim":55.0, - "partner":"5w1q" + "partner":"6o98" }, { "sim":55.0, - "partner":"7kqj" + "partner":"2per" }, { "sim":55.0, - "partner":"6vqf" + "partner":"5w1q" }, { "sim":55.0, @@ -693466,11 +696317,11 @@ }, { "sim":55.0, - "partner":"3d9h" + "partner":"6p9f" }, { "sim":55.0, - "partner":"6p9f" + "partner":"3d9h" }, { "sim":55.0, @@ -693482,15 +696333,19 @@ }, { "sim":55.0, - "partner":"5ita" + "partner":"6vqf" }, { "sim":55.0, - "partner":"6unv" + "partner":"7kqj" }, { "sim":55.0, - "partner":"3p8e" + "partner":"5ita" + }, + { + "sim":55.0, + "partner":"6unv" }, { "sim":55.0, @@ -693508,6 +696363,10 @@ "sim":55.0, "partner":"3p8p" }, + { + "sim":55.0, + "partner":"3p8e" + }, { "sim":55.0, "partner":"5y1d" @@ -693526,11 +696385,11 @@ }, { "sim":55.0, - "partner":"3wcf" + "partner":"3wc9" }, { "sim":55.0, - "partner":"3wc9" + "partner":"3wcf" }, { "sim":55.0, @@ -693582,28 +696441,12 @@ }, { "sim":55.0, - "partner":"4wya" - }, - { - "sim":55.0, - "partner":"4wyf" - }, - { - "sim":55.0, - "partner":"4cxq" - }, - { - "sim":55.0, - "partner":"5kgs" + "partner":"4cxr" }, { "sim":55.0, "partner":"4wyg" }, - { - "sim":55.0, - "partner":"4cxr" - }, { "sim":55.0, "partner":"4xjl" @@ -693668,17 +696511,29 @@ "sim":55.0, "partner":"3tfu" }, + { + "sim":55.0, + "partner":"4wya" + }, { "sim":55.0, "partner":"4wye" }, { "sim":55.0, - "partner":"2inr" + "partner":"4wyf" }, { "sim":55.0, - "partner":"5kdn" + "partner":"4cxq" + }, + { + "sim":55.0, + "partner":"5kgs" + }, + { + "sim":55.0, + "partner":"2inr" }, { "sim":55.0, @@ -693688,6 +696543,10 @@ "sim":55.0, "partner":"5kdu" }, + { + "sim":55.0, + "partner":"5kdn" + }, { "sim":55.0, "partner":"5xzr" @@ -693730,11 +696589,11 @@ }, { "sim":54.0, - "partner":"5c7p" + "partner":"4kpc" }, { "sim":54.0, - "partner":"4kpc" + "partner":"5c7p" }, { "sim":54.0, @@ -693752,10 +696611,6 @@ "sim":54.0, "partner":"2ouk" }, - { - "sim":54.0, - "partner":"7e16" - }, { "sim":54.0, "partner":"3c4j" @@ -693772,6 +696627,10 @@ "sim":54.0, "partner":"2olk" }, + { + "sim":54.0, + "partner":"7e16" + }, { "sim":54.0, "partner":"5hii" @@ -693818,11 +696677,11 @@ }, { "sim":54.0, - "partner":"5lsg" + "partner":"6t9c" }, { "sim":54.0, - "partner":"6t9c" + "partner":"5lsg" }, { "sim":54.0, @@ -693854,15 +696713,15 @@ }, { "sim":54.0, - "partner":"1vsu" + "partner":"1vsv" }, { "sim":54.0, - "partner":"1vsv" + "partner":"3cif" }, { "sim":54.0, - "partner":"3cif" + "partner":"1vsu" }, { "sim":54.0, @@ -693926,7 +696785,7 @@ }, { "sim":54.0, - "partner":"5m12" + "partner":"6gwg" }, { "sim":54.0, @@ -693934,31 +696793,31 @@ }, { "sim":54.0, - "partner":"6gwf" + "partner":"6gta" }, { "sim":54.0, - "partner":"6gwg" + "partner":"5m16" }, { "sim":54.0, - "partner":"5m16" + "partner":"6gvd" }, { "sim":54.0, - "partner":"6gta" + "partner":"5m0x" }, { "sim":54.0, - "partner":"6gvd" + "partner":"6gx8" }, { "sim":54.0, - "partner":"5m0x" + "partner":"5m12" }, { "sim":54.0, - "partner":"6gx8" + "partner":"6gwf" }, { "sim":53.0, @@ -694008,14 +696867,6 @@ "sim":53.0, "partner":"7ck4" }, - { - "sim":53.0, - "partner":"5scp" - }, - { - "sim":53.0, - "partner":"5scq" - }, { "sim":53.0, "partner":"5scr" @@ -694116,6 +696967,14 @@ "sim":53.0, "partner":"5sco" }, + { + "sim":53.0, + "partner":"5scp" + }, + { + "sim":53.0, + "partner":"5scq" + }, { "sim":53.0, "partner":"4ay3" @@ -694130,11 +696989,11 @@ }, { "sim":53.0, - "partner":"6uv7" + "partner":"6uvi" }, { "sim":53.0, - "partner":"6uvi" + "partner":"6uv7" }, { "sim":53.0, @@ -694172,14 +697031,6 @@ "sim":53.0, "partner":"6vio" }, - { - "sim":53.0, - "partner":"6tlm" - }, - { - "sim":53.0, - "partner":"6tlq" - }, { "sim":53.0, "partner":"6tlt" @@ -694212,6 +697063,14 @@ "sim":53.0, "partner":"6t50" }, + { + "sim":53.0, + "partner":"6tlm" + }, + { + "sim":53.0, + "partner":"6tlq" + }, { "sim":53.0, "partner":"6pdk" @@ -694266,23 +697125,23 @@ }, { "sim":53.0, - "partner":"4bf9" + "partner":"2g7m" }, { "sim":53.0, - "partner":"4bfa" + "partner":"2fg6" }, { "sim":53.0, - "partner":"2g7m" + "partner":"2fg7" }, { "sim":53.0, - "partner":"2fg6" + "partner":"4bf9" }, { "sim":53.0, - "partner":"2fg7" + "partner":"4bfa" }, { "sim":53.0, @@ -694308,10 +697167,6 @@ "sim":53.0, "partner":"2fsn" }, - { - "sim":53.0, - "partner":"5zkj" - }, { "sim":53.0, "partner":"6iid" @@ -694326,11 +697181,11 @@ }, { "sim":53.0, - "partner":"5v8y" + "partner":"5zkj" }, { "sim":53.0, - "partner":"5jyf" + "partner":"5v8y" }, { "sim":53.0, @@ -694362,11 +697217,11 @@ }, { "sim":53.0, - "partner":"4myg" + "partner":"5jyf" }, { "sim":53.0, - "partner":"3c1y" + "partner":"4myg" }, { "sim":53.0, @@ -694394,19 +697249,15 @@ }, { "sim":53.0, - "partner":"8t0w" - }, - { - "sim":53.0, - "partner":"8t0u" + "partner":"3c1y" }, { "sim":53.0, - "partner":"3dyh" + "partner":"8t0w" }, { "sim":53.0, - "partner":"4rxd" + "partner":"8t0u" }, { "sim":53.0, @@ -694448,6 +697299,14 @@ "sim":53.0, "partner":"3dyg" }, + { + "sim":53.0, + "partner":"4rxd" + }, + { + "sim":53.0, + "partner":"3dyh" + }, { "sim":53.0, "partner":"4wwv" @@ -694486,15 +697345,15 @@ }, { "sim":53.0, - "partner":"7tfc" + "partner":"7tfe" }, { "sim":53.0, - "partner":"7tfe" + "partner":"7tf9" }, { "sim":53.0, - "partner":"7tf9" + "partner":"7tfc" }, { "sim":53.0, @@ -694518,11 +697377,11 @@ }, { "sim":53.0, - "partner":"4mdo" + "partner":"4mdp" }, { "sim":53.0, - "partner":"4mdp" + "partner":"4mdo" }, { "sim":53.0, @@ -694536,10 +697395,6 @@ "sim":53.0, "partner":"6xt1" }, - { - "sim":53.0, - "partner":"6crm" - }, { "sim":53.0, "partner":"6d23" @@ -694554,16 +697409,20 @@ }, { "sim":53.0, - "partner":"7onw" + "partner":"6crm" }, { "sim":53.0, - "partner":"2vbg" + "partner":"7onw" }, { "sim":53.0, "partner":"2vbf" }, + { + "sim":53.0, + "partner":"2vbg" + }, { "sim":53.0, "partner":"5fqe" @@ -694638,35 +697497,35 @@ }, { "sim":53.0, - "partner":"3ahc" + "partner":"3ahf" }, { "sim":53.0, - "partner":"3ahd" + "partner":"3ahg" }, { "sim":53.0, - "partner":"3ahe" + "partner":"3ahh" }, { "sim":53.0, - "partner":"3ahf" + "partner":"3ahi" }, { "sim":53.0, - "partner":"3ahg" + "partner":"3ahj" }, { "sim":53.0, - "partner":"3ahh" + "partner":"3ahc" }, { "sim":53.0, - "partner":"3ahi" + "partner":"3ahd" }, { "sim":53.0, - "partner":"3ahj" + "partner":"3ahe" }, { "sim":53.0, @@ -694730,15 +697589,15 @@ }, { "sim":52.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":52.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":52.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":52.0, @@ -694760,10 +697619,6 @@ "sim":52.0, "partner":"6lag" }, - { - "sim":52.0, - "partner":"3sw1" - }, { "sim":52.0, "partner":"5j3w" @@ -694776,13 +697631,17 @@ "sim":52.0, "partner":"5j4e" }, + { + "sim":52.0, + "partner":"6gg9" + }, { "sim":52.0, "partner":"7r4s" }, { "sim":52.0, - "partner":"6gg9" + "partner":"3sw1" }, { "sim":52.0, @@ -694808,21 +697667,17 @@ "sim":52.0, "partner":"3l7u" }, - { - "sim":52.0, - "partner":"1x24" - }, { "sim":52.0, "partner":"1zcl" }, { "sim":52.0, - "partner":"3rz2" + "partner":"1x24" }, { "sim":52.0, - "partner":"5l9k" + "partner":"3rz2" }, { "sim":52.0, @@ -694842,16 +697697,20 @@ }, { "sim":52.0, - "partner":"2ccg" + "partner":"5l9k" }, { "sim":52.0, - "partner":"1wc6" + "partner":"2ccg" }, { "sim":52.0, "partner":"1wc1" }, + { + "sim":52.0, + "partner":"1wc6" + }, { "sim":52.0, "partner":"6q2s" @@ -694954,19 +697813,19 @@ }, { "sim":52.0, - "partner":"4rni" + "partner":"4rnj" }, { "sim":52.0, - "partner":"4rnj" + "partner":"4rni" }, { "sim":52.0, - "partner":"5zm4" + "partner":"6pwn" }, { "sim":52.0, - "partner":"6pwn" + "partner":"6uzh" }, { "sim":52.0, @@ -694978,15 +697837,15 @@ }, { "sim":52.0, - "partner":"6uzh" + "partner":"5zm2" }, { "sim":52.0, - "partner":"5zm2" + "partner":"5zm3" }, { "sim":52.0, - "partner":"5zm3" + "partner":"5zm4" }, { "sim":52.0, @@ -695022,11 +697881,11 @@ }, { "sim":52.0, - "partner":"5okt" + "partner":"7nzy" }, { "sim":52.0, - "partner":"7nzy" + "partner":"5okt" }, { "sim":52.0, @@ -695124,25 +697983,13 @@ "sim":52.0, "partner":"3dt1" }, - { - "sim":52.0, - "partner":"6wa9" - }, { "sim":52.0, "partner":"6wa6" }, { "sim":52.0, - "partner":"4i2f" - }, - { - "sim":52.0, - "partner":"4qzb" - }, - { - "sim":52.0, - "partner":"4i2g" + "partner":"6wa9" }, { "sim":52.0, @@ -695252,6 +698099,18 @@ "sim":52.0, "partner":"6b1i" }, + { + "sim":52.0, + "partner":"4i2f" + }, + { + "sim":52.0, + "partner":"4qzb" + }, + { + "sim":52.0, + "partner":"4i2g" + }, { "sim":52.0, "partner":"6go3" @@ -695278,11 +698137,11 @@ }, { "sim":52.0, - "partner":"2gqn" + "partner":"2fq6" }, { "sim":52.0, - "partner":"2fq6" + "partner":"2gqn" }, { "sim":52.0, @@ -695358,11 +698217,11 @@ }, { "sim":52.0, - "partner":"5dt7" + "partner":"5dt5" }, { "sim":52.0, - "partner":"5dt5" + "partner":"5dt7" }, { "sim":52.0, @@ -695398,11 +698257,11 @@ }, { "sim":52.0, - "partner":"1zdl" + "partner":"1zkq" }, { "sim":52.0, - "partner":"1zkq" + "partner":"1zdl" }, { "sim":52.0, @@ -695492,10 +698351,6 @@ "sim":52.0, "partner":"7laf" }, - { - "sim":52.0, - "partner":"3o8y" - }, { "sim":52.0, "partner":"7ttj" @@ -695526,7 +698381,7 @@ }, { "sim":52.0, - "partner":"6k8s" + "partner":"3o8y" }, { "sim":52.0, @@ -695538,15 +698393,15 @@ }, { "sim":52.0, - "partner":"4nre" + "partner":"6k8s" }, { "sim":52.0, - "partner":"8viy" + "partner":"4nre" }, { "sim":52.0, - "partner":"6jr8" + "partner":"8viy" }, { "sim":52.0, @@ -695556,6 +698411,10 @@ "sim":52.0, "partner":"6jr7" }, + { + "sim":52.0, + "partner":"6jr8" + }, { "sim":51.0, "partner":"2lo4" @@ -695576,10 +698435,6 @@ "sim":51.0, "partner":"7ycu" }, - { - "sim":51.0, - "partner":"7vp1" - }, { "sim":51.0, "partner":"7vp2" @@ -695596,6 +698451,10 @@ "sim":51.0, "partner":"7vp4" }, + { + "sim":51.0, + "partner":"7vp1" + }, { "sim":51.0, "partner":"2kgo" @@ -695644,10 +698503,6 @@ "sim":51.0, "partner":"6aq7" }, - { - "sim":51.0, - "partner":"4hmr" - }, { "sim":51.0, "partner":"2wgn" @@ -695670,19 +698525,19 @@ }, { "sim":51.0, - "partner":"2y78" + "partner":"4hmr" }, { "sim":51.0, - "partner":"2i39" + "partner":"2y78" }, { "sim":51.0, - "partner":"4o1h" + "partner":"2i39" }, { "sim":51.0, - "partner":"3qna" + "partner":"4o1h" }, { "sim":51.0, @@ -695696,6 +698551,10 @@ "sim":51.0, "partner":"3qn9" }, + { + "sim":51.0, + "partner":"3qna" + }, { "sim":51.0, "partner":"6l8p" @@ -695728,10 +698587,6 @@ "sim":51.0, "partner":"2bze" }, - { - "sim":51.0, - "partner":"3rg6" - }, { "sim":51.0, "partner":"2wvw" @@ -695746,7 +698601,7 @@ }, { "sim":51.0, - "partner":"5hso" + "partner":"3rg6" }, { "sim":51.0, @@ -695764,6 +698619,10 @@ "sim":51.0, "partner":"5hsm" }, + { + "sim":51.0, + "partner":"5hso" + }, { "sim":51.0, "partner":"5luv" @@ -695774,11 +698633,11 @@ }, { "sim":51.0, - "partner":"5aoz" + "partner":"6o20" }, { "sim":51.0, - "partner":"6o20" + "partner":"5aoz" }, { "sim":51.0, @@ -695790,31 +698649,31 @@ }, { "sim":51.0, - "partner":"7xtl" + "partner":"3l20" }, { "sim":51.0, - "partner":"3l20" + "partner":"7xtl" }, { "sim":51.0, - "partner":"5ujf" + "partner":"4gzd" }, { "sim":51.0, - "partner":"4gzc" + "partner":"6gum" }, { "sim":51.0, - "partner":"4gzd" + "partner":"6gv3" }, { "sim":51.0, - "partner":"6gum" + "partner":"5ujf" }, { "sim":51.0, - "partner":"6gv3" + "partner":"4gzc" }, { "sim":51.0, @@ -695826,15 +698685,15 @@ }, { "sim":51.0, - "partner":"5t0z" + "partner":"7efj" }, { "sim":51.0, - "partner":"7efj" + "partner":"7f0m" }, { "sim":51.0, - "partner":"7f0m" + "partner":"5t0z" }, { "sim":51.0, @@ -695852,10 +698711,6 @@ "sim":51.0, "partner":"2cdn" }, - { - "sim":51.0, - "partner":"6f3z" - }, { "sim":51.0, "partner":"5lnm" @@ -695866,19 +698721,19 @@ }, { "sim":51.0, - "partner":"2d7j" + "partner":"6f3z" }, { "sim":51.0, - "partner":"6pj9" + "partner":"2d7j" }, { "sim":51.0, - "partner":"6pja" + "partner":"6pjp" }, { "sim":51.0, - "partner":"6pjp" + "partner":"6pjq" }, { "sim":51.0, @@ -695886,11 +698741,11 @@ }, { "sim":51.0, - "partner":"6pjq" + "partner":"6pjr" }, { "sim":51.0, - "partner":"6pjr" + "partner":"6pju" }, { "sim":51.0, @@ -695900,10 +698755,6 @@ "sim":51.0, "partner":"5f5d" }, - { - "sim":51.0, - "partner":"6pju" - }, { "sim":51.0, "partner":"4njp" @@ -695926,15 +698777,19 @@ }, { "sim":51.0, - "partner":"5f5j" + "partner":"6pj5" }, { "sim":51.0, - "partner":"6pj5" + "partner":"6pj7" }, { "sim":51.0, - "partner":"6pj7" + "partner":"5f5j" + }, + { + "sim":51.0, + "partner":"6pj8" }, { "sim":51.0, @@ -695942,7 +698797,11 @@ }, { "sim":51.0, - "partner":"6pj8" + "partner":"6pj9" + }, + { + "sim":51.0, + "partner":"6pja" }, { "sim":51.0, @@ -695962,11 +698821,11 @@ }, { "sim":51.0, - "partner":"6nko" + "partner":"4oki" }, { "sim":51.0, - "partner":"4oki" + "partner":"6nko" }, { "sim":51.0, @@ -696002,19 +698861,19 @@ }, { "sim":51.0, - "partner":"5n7o" + "partner":"6hry" }, { "sim":51.0, - "partner":"6hry" + "partner":"5n7o" }, { "sim":51.0, - "partner":"5n1c" + "partner":"6hrz" }, { "sim":51.0, - "partner":"6hrz" + "partner":"5n1c" }, { "sim":51.0, @@ -696062,27 +698921,27 @@ }, { "sim":51.0, - "partner":"8vip" + "partner":"7p1y" }, { "sim":51.0, - "partner":"8viq" + "partner":"8vit" }, { "sim":51.0, - "partner":"7p1y" + "partner":"2xx3" }, { "sim":51.0, - "partner":"8vir" + "partner":"8vip" }, { "sim":51.0, - "partner":"8vit" + "partner":"8viq" }, { "sim":51.0, - "partner":"2xx3" + "partner":"8vir" }, { "sim":51.0, @@ -696102,16 +698961,12 @@ }, { "sim":51.0, - "partner":"7o2t" + "partner":"6z17" }, { "sim":51.0, "partner":"7o2u" }, - { - "sim":51.0, - "partner":"6z17" - }, { "sim":51.0, "partner":"6yz3" @@ -696128,6 +698983,10 @@ "sim":51.0, "partner":"6z5k" }, + { + "sim":51.0, + "partner":"7o2t" + }, { "sim":51.0, "partner":"4d7l" @@ -696268,18 +699127,6 @@ "sim":51.0, "partner":"4qts" }, - { - "sim":51.0, - "partner":"6ub4" - }, - { - "sim":51.0, - "partner":"6ub5" - }, - { - "sim":51.0, - "partner":"6ub6" - }, { "sim":51.0, "partner":"5t65" @@ -696306,15 +699153,15 @@ }, { "sim":51.0, - "partner":"5ds3" + "partner":"6ub4" }, { "sim":51.0, - "partner":"6bhv" + "partner":"6ub5" }, { "sim":51.0, - "partner":"1z5z" + "partner":"6ub6" }, { "sim":51.0, @@ -696344,6 +699191,18 @@ "sim":51.0, "partner":"6nrj" }, + { + "sim":51.0, + "partner":"6bhv" + }, + { + "sim":51.0, + "partner":"5ds3" + }, + { + "sim":51.0, + "partner":"1z5z" + }, { "sim":51.0, "partner":"2rhr" @@ -696370,11 +699229,11 @@ }, { "sim":51.0, - "partner":"5c2d" + "partner":"6dli" }, { "sim":51.0, - "partner":"6dli" + "partner":"5c2d" }, { "sim":51.0, @@ -696430,11 +699289,11 @@ }, { "sim":51.0, - "partner":"6fcn" + "partner":"6fcm" }, { "sim":51.0, - "partner":"6fcm" + "partner":"6fcn" }, { "sim":51.0, @@ -696450,24 +699309,12 @@ }, { "sim":51.0, - "partner":"5coq" - }, - { - "sim":51.0, - "partner":"5cpb" - }, - { - "sim":51.0, - "partner":"5mtr" + "partner":"4oxk" }, { "sim":51.0, "partner":"5ugt" }, - { - "sim":51.0, - "partner":"4oxk" - }, { "sim":51.0, "partner":"5ugu" @@ -696478,15 +699325,15 @@ }, { "sim":51.0, - "partner":"4oxn" + "partner":"6yuu" }, { "sim":51.0, - "partner":"4oyr" + "partner":"4oxn" }, { "sim":51.0, - "partner":"6yuu" + "partner":"4oyr" }, { "sim":51.0, @@ -696512,13 +699359,21 @@ "sim":51.0, "partner":"5cp8" }, + { + "sim":51.0, + "partner":"5mtr" + }, { "sim":51.0, "partner":"5ugs" }, { "sim":51.0, - "partner":"5lto" + "partner":"5cpb" + }, + { + "sim":51.0, + "partner":"5coq" }, { "sim":51.0, @@ -696544,6 +699399,10 @@ "sim":51.0, "partner":"4cp2" }, + { + "sim":51.0, + "partner":"5lto" + }, { "sim":51.0, "partner":"5e0n" @@ -696564,10 +699423,6 @@ "sim":51.0, "partner":"1w4t" }, - { - "sim":51.0, - "partner":"3s3h" - }, { "sim":51.0, "partner":"3s3k" @@ -696582,7 +699437,7 @@ }, { "sim":51.0, - "partner":"7xif" + "partner":"3s3h" }, { "sim":51.0, @@ -696596,6 +699451,10 @@ "sim":51.0, "partner":"7xii" }, + { + "sim":51.0, + "partner":"7xif" + }, { "sim":51.0, "partner":"7e4m" @@ -696690,15 +699549,15 @@ }, { "sim":51.0, - "partner":"4w7v" + "partner":"4w7u" }, { "sim":51.0, - "partner":"4w7w" + "partner":"4w7v" }, { "sim":51.0, - "partner":"4w7u" + "partner":"4w7w" }, { "sim":51.0, @@ -696720,14 +699579,6 @@ "sim":51.0, "partner":"7cgv" }, - { - "sim":51.0, - "partner":"5gg5" - }, - { - "sim":51.0, - "partner":"5xd1" - }, { "sim":51.0, "partner":"5gg6" @@ -696740,6 +699591,10 @@ "sim":51.0, "partner":"5xd3" }, + { + "sim":51.0, + "partner":"6m6y" + }, { "sim":51.0, "partner":"5gg7" @@ -696750,11 +699605,11 @@ }, { "sim":51.0, - "partner":"5xd5" + "partner":"6m65" }, { "sim":51.0, - "partner":"6m6y" + "partner":"5xd5" }, { "sim":51.0, @@ -696764,10 +699619,6 @@ "sim":51.0, "partner":"5hos" }, - { - "sim":51.0, - "partner":"6m65" - }, { "sim":51.0, "partner":"5gg9" @@ -696796,6 +699647,14 @@ "sim":51.0, "partner":"6m69" }, + { + "sim":51.0, + "partner":"5gg5" + }, + { + "sim":51.0, + "partner":"5xd1" + }, { "sim":51.0, "partner":"5m8b" @@ -696848,10 +699707,6 @@ "sim":51.0, "partner":"7voc" }, - { - "sim":51.0, - "partner":"4m1i" - }, { "sim":51.0, "partner":"5b6k" @@ -696872,6 +699727,10 @@ "sim":51.0, "partner":"4m1h" }, + { + "sim":51.0, + "partner":"4m1i" + }, { "sim":51.0, "partner":"6eow" @@ -696924,10 +699783,6 @@ "sim":51.0, "partner":"4ot7" }, - { - "sim":51.0, - "partner":"6put" - }, { "sim":51.0, "partner":"6puw" @@ -696942,15 +699797,15 @@ }, { "sim":51.0, - "partner":"5u1c" + "partner":"6puz" }, { "sim":51.0, - "partner":"6puz" + "partner":"5u1c" }, { "sim":51.0, - "partner":"6ojx" + "partner":"6put" }, { "sim":51.0, @@ -696982,16 +699837,20 @@ }, { "sim":51.0, - "partner":"7dmb" + "partner":"6ojx" }, { "sim":51.0, - "partner":"8bao" + "partner":"7dmb" }, { "sim":51.0, "partner":"5j8x" }, + { + "sim":51.0, + "partner":"8bao" + }, { "sim":51.0, "partner":"5tzb" @@ -697068,10 +699927,6 @@ "sim":51.0, "partner":"3k01" }, - { - "sim":51.0, - "partner":"4lre" - }, { "sim":51.0, "partner":"4lrf" @@ -697106,11 +699961,11 @@ }, { "sim":51.0, - "partner":"5xpj" + "partner":"4lre" }, { "sim":51.0, - "partner":"5dvi" + "partner":"5xpj" }, { "sim":51.0, @@ -697120,6 +699975,10 @@ "sim":51.0, "partner":"5dvf" }, + { + "sim":51.0, + "partner":"5dvi" + }, { "sim":51.0, "partner":"2zvi" @@ -697190,27 +700049,27 @@ }, { "sim":51.0, - "partner":"6ry0" + "partner":"6ry5" }, { "sim":51.0, - "partner":"6ry1" + "partner":"6ry6" }, { "sim":51.0, - "partner":"6ry2" + "partner":"6ry7" }, { "sim":51.0, - "partner":"6ry5" + "partner":"6ry0" }, { "sim":51.0, - "partner":"6ry6" + "partner":"6ry1" }, { "sim":51.0, - "partner":"6ry7" + "partner":"6ry2" }, { "sim":51.0, @@ -697308,14 +700167,6 @@ "sim":51.0, "partner":"5hat" }, - { - "sim":51.0, - "partner":"5hjx" - }, - { - "sim":51.0, - "partner":"5koz" - }, { "sim":51.0, "partner":"5hjy" @@ -697336,6 +700187,10 @@ "sim":51.0, "partner":"4lf1" }, + { + "sim":51.0, + "partner":"5koz" + }, { "sim":51.0, "partner":"4lf2" @@ -697346,15 +700201,15 @@ }, { "sim":51.0, - "partner":"7jrl" + "partner":"5hjx" }, { "sim":51.0, - "partner":"5hqm" + "partner":"7jrl" }, { "sim":51.0, - "partner":"6rk2" + "partner":"5hqm" }, { "sim":51.0, @@ -697370,19 +700225,19 @@ }, { "sim":51.0, - "partner":"6jmw" + "partner":"6rk2" }, { "sim":51.0, - "partner":"6jzs" + "partner":"6jmw" }, { "sim":51.0, - "partner":"5l77" + "partner":"6jzs" }, { "sim":51.0, - "partner":"6pt4" + "partner":"5l77" }, { "sim":51.0, @@ -697396,6 +700251,10 @@ "sim":51.0, "partner":"6ptk" }, + { + "sim":51.0, + "partner":"6pt4" + }, { "sim":51.0, "partner":"6rim" @@ -697468,10 +700327,6 @@ "sim":51.0, "partner":"7all" }, - { - "sim":51.0, - "partner":"3qp9" - }, { "sim":51.0, "partner":"3sur" @@ -697508,13 +700363,17 @@ "sim":51.0, "partner":"3gh7" }, + { + "sim":51.0, + "partner":"3qp9" + }, { "sim":51.0, "partner":"6l4o" }, { "sim":51.0, - "partner":"6p00" + "partner":"6p2v" }, { "sim":51.0, @@ -697522,7 +700381,7 @@ }, { "sim":51.0, - "partner":"6p2v" + "partner":"6p00" }, { "sim":51.0, @@ -697544,14 +700403,6 @@ "sim":51.0, "partner":"5kd5" }, - { - "sim":51.0, - "partner":"4ids" - }, - { - "sim":51.0, - "partner":"4jdc" - }, { "sim":51.0, "partner":"7mer" @@ -697612,6 +700463,14 @@ "sim":51.0, "partner":"4lh3" }, + { + "sim":51.0, + "partner":"4ids" + }, + { + "sim":51.0, + "partner":"4jdc" + }, { "sim":51.0, "partner":"3hx6" @@ -697634,11 +700493,11 @@ }, { "sim":51.0, - "partner":"7jwf" + "partner":"7jw4" }, { "sim":51.0, - "partner":"7jw4" + "partner":"7jwf" }, { "sim":51.0, @@ -697658,23 +700517,23 @@ }, { "sim":51.0, - "partner":"7vzz" + "partner":"7vzq" }, { "sim":51.0, - "partner":"7vzu" + "partner":"7vx0" }, { "sim":51.0, - "partner":"7vzq" + "partner":"7vzy" }, { "sim":51.0, - "partner":"7vx0" + "partner":"7vzz" }, { "sim":51.0, - "partner":"7vzy" + "partner":"7vzu" }, { "sim":51.0, @@ -697684,10 +700543,6 @@ "sim":51.0, "partner":"5x7h" }, - { - "sim":51.0, - "partner":"7wlg" - }, { "sim":51.0, "partner":"7wj9" @@ -697716,6 +700571,10 @@ "sim":51.0, "partner":"7wjf" }, + { + "sim":51.0, + "partner":"7wlg" + }, { "sim":51.0, "partner":"3zvr" @@ -697732,14 +700591,6 @@ "sim":51.0, "partner":"3slk" }, - { - "sim":51.0, - "partner":"4j3t" - }, - { - "sim":51.0, - "partner":"4j3u" - }, { "sim":51.0, "partner":"4j3v" @@ -697758,7 +700609,11 @@ }, { "sim":51.0, - "partner":"5y1h" + "partner":"4j3t" + }, + { + "sim":51.0, + "partner":"4j3u" }, { "sim":51.0, @@ -697804,6 +700659,10 @@ "sim":51.0, "partner":"5y3i" }, + { + "sim":51.0, + "partner":"5y1h" + }, { "sim":51.0, "partner":"5wmm" @@ -697844,10 +700703,6 @@ "sim":51.0, "partner":"3va7" }, - { - "sim":51.0, - "partner":"6yt0" - }, { "sim":51.0, "partner":"4zhj" @@ -697864,6 +700719,10 @@ "sim":51.0, "partner":"6ytj" }, + { + "sim":51.0, + "partner":"6yt0" + }, { "sim":50.0, "partner":"4omp" @@ -698048,10 +700907,6 @@ "sim":50.0, "partner":"2ozn" }, - { - "sim":50.0, - "partner":"7c1j" - }, { "sim":50.0, "partner":"7cfw" @@ -698062,12 +700917,16 @@ }, { "sim":50.0, - "partner":"2wja" + "partner":"7c1j" }, { "sim":50.0, "partner":"7a6p" }, + { + "sim":50.0, + "partner":"2wja" + }, { "sim":50.0, "partner":"3w95" @@ -698160,10 +701019,6 @@ "sim":50.0, "partner":"2j8k" }, - { - "sim":50.0, - "partner":"3th5" - }, { "sim":50.0, "partner":"4gzl" @@ -698178,15 +701033,15 @@ }, { "sim":50.0, - "partner":"3p6b" + "partner":"3th5" }, { "sim":50.0, - "partner":"7q4s" + "partner":"3p6b" }, { "sim":50.0, - "partner":"5n2n" + "partner":"7q4s" }, { "sim":50.0, @@ -698194,15 +701049,15 @@ }, { "sim":50.0, - "partner":"3mmn" + "partner":"5n2n" }, { "sim":50.0, - "partner":"3mm4" + "partner":"3mmn" }, { "sim":50.0, - "partner":"3l1u" + "partner":"3mm4" }, { "sim":50.0, @@ -698220,6 +701075,10 @@ "sim":50.0, "partner":"3esr" }, + { + "sim":50.0, + "partner":"3l1u" + }, { "sim":50.0, "partner":"2l22" @@ -698306,31 +701165,31 @@ }, { "sim":50.0, - "partner":"7mnq" + "partner":"7mns" }, { "sim":50.0, - "partner":"7mnr" + "partner":"7mnt" }, { "sim":50.0, - "partner":"7mns" + "partner":"4irb" }, { "sim":50.0, - "partner":"4irb" + "partner":"7mnu" }, { "sim":50.0, - "partner":"7mnt" + "partner":"7mnv" }, { "sim":50.0, - "partner":"7mnu" + "partner":"7mnq" }, { "sim":50.0, - "partner":"7mnv" + "partner":"7mnr" }, { "sim":50.0, @@ -698360,10 +701219,6 @@ "sim":50.0, "partner":"7cg9" }, - { - "sim":50.0, - "partner":"5cvd" - }, { "sim":50.0, "partner":"5cve" @@ -698374,11 +701229,7 @@ }, { "sim":50.0, - "partner":"4bmx" - }, - { - "sim":50.0, - "partner":"4bmy" + "partner":"5cvd" }, { "sim":50.0, @@ -698394,7 +701245,11 @@ }, { "sim":50.0, - "partner":"4da6" + "partner":"4bmx" + }, + { + "sim":50.0, + "partner":"4bmy" }, { "sim":50.0, @@ -698450,15 +701305,15 @@ }, { "sim":50.0, - "partner":"2vh2" + "partner":"4da6" }, { "sim":50.0, - "partner":"2q60" + "partner":"2vh2" }, { "sim":50.0, - "partner":"5h5a" + "partner":"2q60" }, { "sim":50.0, @@ -698468,6 +701323,10 @@ "sim":50.0, "partner":"5owf" }, + { + "sim":50.0, + "partner":"5h5a" + }, { "sim":50.0, "partner":"3h1z" @@ -698528,10 +701387,6 @@ "sim":50.0, "partner":"4y7j" }, - { - "sim":50.0, - "partner":"3dbp" - }, { "sim":50.0, "partner":"3mo7" @@ -698554,11 +701409,11 @@ }, { "sim":50.0, - "partner":"3uic" + "partner":"3dbp" }, { "sim":50.0, - "partner":"4j3f" + "partner":"3uic" }, { "sim":50.0, @@ -698574,31 +701429,35 @@ }, { "sim":50.0, - "partner":"4jqc" + "partner":"4j3f" }, { "sim":50.0, - "partner":"6t2p" + "partner":"6akv" }, { "sim":50.0, - "partner":"2wk1" + "partner":"6t2o" }, { "sim":50.0, - "partner":"6t2q" + "partner":"4jx8" }, { "sim":50.0, - "partner":"6akv" + "partner":"6t2p" }, { "sim":50.0, - "partner":"4jx8" + "partner":"4jqc" }, { "sim":50.0, - "partner":"6t2o" + "partner":"6t2q" + }, + { + "sim":50.0, + "partner":"2wk1" }, { "sim":50.0, @@ -698614,31 +701473,31 @@ }, { "sim":50.0, - "partner":"3quo" + "partner":"3qur" }, { "sim":50.0, - "partner":"3qvf" + "partner":"3qvh" }, { "sim":50.0, - "partner":"3qur" + "partner":"3d40" }, { "sim":50.0, - "partner":"3qvh" + "partner":"3d41" }, { "sim":50.0, - "partner":"3d40" + "partner":"3qun" }, { "sim":50.0, - "partner":"3d41" + "partner":"3quo" }, { "sim":50.0, - "partner":"3qun" + "partner":"3qvf" }, { "sim":50.0, @@ -698650,19 +701509,19 @@ }, { "sim":50.0, - "partner":"7a61" + "partner":"8rwq" }, { "sim":50.0, - "partner":"5uj3" + "partner":"6mnp" }, { "sim":50.0, - "partner":"5uj4" + "partner":"8rwr" }, { "sim":50.0, - "partner":"6mnp" + "partner":"5uj3" }, { "sim":50.0, @@ -698670,7 +701529,11 @@ }, { "sim":50.0, - "partner":"5ul8" + "partner":"8rws" + }, + { + "sim":50.0, + "partner":"5uj4" }, { "sim":50.0, @@ -698684,6 +701547,10 @@ "sim":50.0, "partner":"6d17" }, + { + "sim":50.0, + "partner":"5ul8" + }, { "sim":50.0, "partner":"6d18" @@ -698724,10 +701591,6 @@ "sim":50.0, "partner":"6z24" }, - { - "sim":50.0, - "partner":"4o0q" - }, { "sim":50.0, "partner":"6qwd" @@ -698742,7 +701605,7 @@ }, { "sim":50.0, - "partner":"8rwq" + "partner":"4o0q" }, { "sim":50.0, @@ -698756,10 +701619,6 @@ "sim":50.0, "partner":"6v7i" }, - { - "sim":50.0, - "partner":"4o1e" - }, { "sim":50.0, "partner":"6m7i" @@ -698772,10 +701631,26 @@ "sim":50.0, "partner":"6td1" }, + { + "sim":50.0, + "partner":"4o1e" + }, { "sim":50.0, "partner":"4o1f" }, + { + "sim":50.0, + "partner":"7a61" + }, + { + "sim":50.0, + "partner":"8rwo" + }, + { + "sim":50.0, + "partner":"8rwp" + }, { "sim":50.0, "partner":"4ic5" @@ -698838,11 +701713,11 @@ }, { "sim":50.0, - "partner":"2qj3" + "partner":"7my7" }, { "sim":50.0, - "partner":"7my7" + "partner":"2qj3" }, { "sim":50.0, @@ -698864,14 +701739,6 @@ "sim":50.0, "partner":"5yr7" }, - { - "sim":50.0, - "partner":"2nq6" - }, - { - "sim":50.0, - "partner":"2nq7" - }, { "sim":50.0, "partner":"2b3k" @@ -698914,7 +701781,11 @@ }, { "sim":50.0, - "partner":"2pzm" + "partner":"2nq6" + }, + { + "sim":50.0, + "partner":"2nq7" }, { "sim":50.0, @@ -698926,12 +701797,16 @@ }, { "sim":50.0, - "partner":"6lcn" + "partner":"2pzm" }, { "sim":50.0, "partner":"7x1l" }, + { + "sim":50.0, + "partner":"6lcn" + }, { "sim":50.0, "partner":"7f8d" @@ -699026,99 +701901,99 @@ }, { "sim":50.0, - "partner":"1xoq" + "partner":"1y2b" }, { "sim":50.0, - "partner":"6ind" + "partner":"6imt" }, { "sim":50.0, - "partner":"1xor" + "partner":"1y2c" }, { "sim":50.0, - "partner":"3iak" + "partner":"6ink" }, { "sim":50.0, - "partner":"6imr" + "partner":"1y2d" }, { "sim":50.0, - "partner":"7cbj" + "partner":"1y2e" }, { "sim":50.0, - "partner":"1y2b" + "partner":"6inm" }, { "sim":50.0, - "partner":"6im6" + "partner":"6imb" }, { "sim":50.0, - "partner":"6imt" + "partner":"7cbq" }, { "sim":50.0, - "partner":"1y2c" + "partner":"6imd" }, { "sim":50.0, - "partner":"1y2d" + "partner":"1y2k" }, { "sim":50.0, - "partner":"6ink" + "partner":"6imi" }, { "sim":50.0, - "partner":"1y2e" + "partner":"6imo" }, { "sim":50.0, - "partner":"6inm" + "partner":"6lrm" }, { "sim":50.0, - "partner":"6imb" + "partner":"1xom" }, { "sim":50.0, - "partner":"7cbq" + "partner":"1xon" }, { "sim":50.0, - "partner":"6imd" + "partner":"3k4s" }, { "sim":50.0, - "partner":"1y2k" + "partner":"6ind" }, { "sim":50.0, - "partner":"1xom" + "partner":"1xoq" }, { "sim":50.0, - "partner":"6imi" + "partner":"7cbj" }, { "sim":50.0, - "partner":"6imo" + "partner":"6imr" }, { "sim":50.0, - "partner":"6lrm" + "partner":"1xor" }, { "sim":50.0, - "partner":"1xon" + "partner":"6im6" }, { "sim":50.0, - "partner":"3k4s" + "partner":"3iak" }, { "sim":50.0, @@ -699172,18 +702047,6 @@ "sim":50.0, "partner":"4ilk" }, - { - "sim":50.0, - "partner":"4m25" - }, - { - "sim":50.0, - "partner":"4m2i" - }, - { - "sim":50.0, - "partner":"4ne0" - }, { "sim":50.0, "partner":"4m26" @@ -699220,6 +702083,18 @@ "sim":50.0, "partner":"4m2g" }, + { + "sim":50.0, + "partner":"4m25" + }, + { + "sim":50.0, + "partner":"4m2i" + }, + { + "sim":50.0, + "partner":"4ne0" + }, { "sim":50.0, "partner":"3wcg" @@ -699284,22 +702159,6 @@ "sim":50.0, "partner":"2nqo" }, - { - "sim":50.0, - "partner":"5zzx" - }, - { - "sim":50.0, - "partner":"6a0d" - }, - { - "sim":50.0, - "partner":"5zzy" - }, - { - "sim":50.0, - "partner":"6a0v" - }, { "sim":50.0, "partner":"5zzz" @@ -699440,6 +702299,22 @@ "sim":50.0, "partner":"6a21" }, + { + "sim":50.0, + "partner":"5zzx" + }, + { + "sim":50.0, + "partner":"6a0d" + }, + { + "sim":50.0, + "partner":"5zzy" + }, + { + "sim":50.0, + "partner":"6a0v" + }, { "sim":50.0, "partner":"4gmg" @@ -699470,31 +702345,31 @@ }, { "sim":50.0, - "partner":"6zgp" + "partner":"6y9d" }, { "sim":50.0, - "partner":"6y8j" + "partner":"6zgp" }, { "sim":50.0, - "partner":"6y9c" + "partner":"2qap" }, { "sim":50.0, - "partner":"6y9d" + "partner":"6y8s" }, { "sim":50.0, - "partner":"2qap" + "partner":"2qdg" }, { "sim":50.0, - "partner":"6y8s" + "partner":"6y8j" }, { "sim":50.0, - "partner":"2qdg" + "partner":"6y9c" }, { "sim":50.0, @@ -699510,11 +702385,11 @@ }, { "sim":50.0, - "partner":"5ta7" + "partner":"5ta9" }, { "sim":50.0, - "partner":"5ta9" + "partner":"5ta7" }, { "sim":50.0, @@ -699614,15 +702489,15 @@ }, { "sim":50.0, - "partner":"4euh" + "partner":"4eue" }, { "sim":50.0, - "partner":"4eue" + "partner":"4euf" }, { "sim":50.0, - "partner":"4euf" + "partner":"4euh" }, { "sim":50.0, @@ -699666,15 +702541,15 @@ }, { "sim":50.0, - "partner":"5z8a" + "partner":"5z8k" }, { "sim":50.0, - "partner":"5z8k" + "partner":"5z83" }, { "sim":50.0, - "partner":"5z83" + "partner":"5z8a" }, { "sim":50.0, @@ -699744,10 +702619,6 @@ "sim":50.0, "partner":"3ugq" }, - { - "sim":50.0, - "partner":"4acg" - }, { "sim":50.0, "partner":"4ach" @@ -699762,19 +702633,19 @@ }, { "sim":50.0, - "partner":"5y9h" + "partner":"4acg" }, { "sim":50.0, - "partner":"4il0" + "partner":"5y9h" }, { "sim":50.0, - "partner":"6qps" + "partner":"4il0" }, { "sim":50.0, - "partner":"2wc4" + "partner":"6qps" }, { "sim":50.0, @@ -699890,7 +702761,7 @@ }, { "sim":50.0, - "partner":"2gps" + "partner":"2wc4" }, { "sim":50.0, @@ -699898,11 +702769,15 @@ }, { "sim":50.0, - "partner":"6oi9" + "partner":"2gpw" }, { "sim":50.0, - "partner":"2gpw" + "partner":"2gps" + }, + { + "sim":50.0, + "partner":"6oi9" }, { "sim":50.0, @@ -699940,10 +702815,6 @@ "sim":50.0, "partner":"5ti8" }, - { - "sim":50.0, - "partner":"5v59" - }, { "sim":50.0, "partner":"4dod" @@ -699960,6 +702831,10 @@ "sim":50.0, "partner":"4xeo" }, + { + "sim":50.0, + "partner":"5v59" + }, { "sim":50.0, "partner":"6bia" @@ -700020,10 +702895,6 @@ "sim":50.0, "partner":"4ife" }, - { - "sim":50.0, - "partner":"5uno" - }, { "sim":50.0, "partner":"7m7c" @@ -700042,11 +702913,11 @@ }, { "sim":50.0, - "partner":"4l6w" + "partner":"5uno" }, { "sim":50.0, - "partner":"6x0h" + "partner":"4l6w" }, { "sim":50.0, @@ -700058,15 +702929,15 @@ }, { "sim":50.0, - "partner":"6pop" + "partner":"6x0h" }, { "sim":50.0, - "partner":"6pnu" + "partner":"6pop" }, { "sim":50.0, - "partner":"4dqw" + "partner":"6pnu" }, { "sim":50.0, @@ -700082,12 +702953,16 @@ }, { "sim":50.0, - "partner":"7an1" + "partner":"4dqw" }, { "sim":50.0, "partner":"7oqd" }, + { + "sim":50.0, + "partner":"7an1" + }, { "sim":50.0, "partner":"5m1c" @@ -700206,23 +703081,23 @@ }, { "sim":50.0, - "partner":"7aqu" + "partner":"7cu0" }, { "sim":50.0, - "partner":"7aqv" + "partner":"7cu1" }, { "sim":50.0, - "partner":"7cu0" + "partner":"7cu2" }, { "sim":50.0, - "partner":"7cu1" + "partner":"7aqu" }, { "sim":50.0, - "partner":"7cu2" + "partner":"7aqv" }, { "sim":50.0, @@ -700328,10 +703203,6 @@ "sim":50.0, "partner":"8r72" }, - { - "sim":50.0, - "partner":"2fw3" - }, { "sim":50.0, "partner":"4ep9" @@ -700352,6 +703223,10 @@ "sim":50.0, "partner":"4eph" }, + { + "sim":50.0, + "partner":"2fw3" + }, { "sim":50.0, "partner":"4gw9" @@ -700382,15 +703257,15 @@ }, { "sim":50.0, - "partner":"7w1c" + "partner":"7w1d" }, { "sim":50.0, - "partner":"7w1d" + "partner":"7w1e" }, { "sim":50.0, - "partner":"7w1e" + "partner":"7w1c" }, { "sim":50.0, @@ -700442,15 +703317,15 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"6edz" }, { "sim":50.0, - "partner":"6edz" + "partner":"6ee1" }, { "sim":50.0, - "partner":"6ee1" + "partner":"6edw" }, { "sim":50.0, @@ -700521,110 +703396,134 @@ "surname":"Wu" }, { - "forename":"R.", - "surname":"Kammerer" + "forename":"G.", + "surname":"Zanetti" + }, + { + "forename":"S.", + "surname":"Furler" + }, + { + "forename":"T.", + "surname":"Reinberg" + }, + { + "forename":"J.", + "surname":"Marinho" + }, + { + "forename":"J.V.", + "surname":"Schaefer" + }, + { + "forename":"A.", + "surname":"Pluckthun" }, { "forename":"X.", "surname":"Li" }, { - "forename":"A.", - "surname":"Plueckthun" + "forename":"M.", + "surname":"Pirazzini" + }, + { + "forename":"R.A.", + "surname":"Kammerer" } ], "classification":"unknown", "classification_suggested":[ - + "consensus" ], "classification_suggested_reason":[ - + "Author is: A. Pluckthun" ], "subtitle":"Crystal structure of the lc\/a1-darpin18 complex", "tags":[ - "darpin", + "toxin", "catalytic domain", "botulinum neurotoxin", - "toxin" + "darpin" ], "keywords":[ - "inhibits", - "plays", - "cleavage", - "results", - "tissue", - "indicating", - "critical", - "proteins", - "reveals", - "long", - "asp", - "study", - "combined", - "contrast", - "inhibitor", - "increasing", - "tools", - "crystallography", - "darpins", - "identify", "designed", - "onset", - "substrate", + "botulinum", "interacting", - "ankyrin", - "persistence", - "darpin", - "found", - "region", - "characterize", - "activity", - "mutation", - "promotes", + "critical", + "role", + "probe", + "repeat", + "action", "requiring", - "vitro", + "neurotoxin", + "substrate", "translocation", - "a1", - "blocks", - "inhibition", - "implications", - "application", - "action", - "findings", - "probe", - "residue", + "onset", + "darpin", "muscle", - "loss", + "toxin", + "application", "structure", - "neurotoxin", - "function", - "repeat", + "important", + "indicating", + "inhibitor", "block", - "investigative", - "faster", + "results", + "residue", + "therapeutic", + "loss", + "findings", "could", - "areas", - "botulinum", + "persistence", + "crystallography", + "study", "snap25", + "plays", + "function", + "completely", + "tissue", + "combined", + "blocks", + "proteins", + "vitro", + "interaction", + "cleavage", "primary", - "role", + "identify", + "ankyrin", + "contrast", + "faster", + "activity", + "asp", + "reveals", + "found", + "implications", + "inhibition", + "region", + "long", + "a1", + "darpins", + "investigative", + "tools", + "inhibits", + "characterize", + "mutation", "neurons", - "therapeutic", - "completely", - "important", - "toxin", - "interaction" + "increasing", + "areas", + "promotes" ], "release_date":"2023-11-29", - "publication":"To be published", + "publication":"\"A DARPin promotes faster onset of botulinum neurotoxin A1 action\", Nat Commun, 14, 8317-8317", "publication_ref":{ - "DOI":"", - "PubMed":"", + "DOI":"10.1038\/s41467-023-44102-4", + "PubMed":"38110403", "CSD":"", - "ISSN":"", + "ISSN":"2041-1723", "ASTM":"" }, - "publication_country":"", + "publication_country":"UK", "abstract":"In this study, we characterize Designed Ankyrin Repeat Proteins (DARPins) as investigative tools to probe botulinum neurotoxin A1 (BoNT\/A1) structure and function. We identify DARPin-F5 that completely blocks SNAP25 substrate cleavage by BoNT\/A1 in vitro. X-ray crystallography reveals that DARPin-F5 inhibits BoNT\/A1 activity by interacting with a substrate-binding region between the \u03b1- and \u03b2-exosite. This DARPin does not block substrate cleavage of BoNT\/A3, indicating that DARPin-F5 is a subtype-specific inhibitor. BoNT\/A1 Glu-171 plays a critical role in the interaction with DARPin-F5 and its mutation to Asp, the residue found in BoNT\/A3, results in a loss of inhibition of substrate cleavage. In contrast to the in vitro results, DARPin-F5 promotes faster substrate cleavage of BoNT\/A1 in primary neurons and muscle tissue by increasing toxin translocation. Our findings could have important implications for the application of BoNT\/A1 in therapeutic areas requiring faster onset of toxin action combined with long persistence.", "crystal_structure":{ "length_a":"59.560", @@ -700666,19 +703565,19 @@ }, { "sim":215.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":215.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":213.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":213.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":213.0, @@ -700730,19 +703629,19 @@ }, { "sim":207.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":207.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":207.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":207.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":207.0, @@ -700750,35 +703649,35 @@ }, { "sim":207.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":207.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":207.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":207.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":207.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":207.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":207.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":207.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":206.0, @@ -700844,6 +703743,10 @@ "sim":197.0, "partner":"8aiw" }, + { + "sim":196.0, + "partner":"9glq" + }, { "sim":196.0, "partner":"2xee" @@ -700878,7 +703781,7 @@ }, { "sim":192.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":192.0, @@ -700886,7 +703789,7 @@ }, { "sim":192.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":192.0, @@ -700922,11 +703825,11 @@ }, { "sim":181.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":181.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":181.0, @@ -701010,10 +703913,6 @@ } ], "seq_thr_sim_natural":[ - { - "sim":259.0, - "partner":"7pd8" - }, { "sim":259.0, "partner":"7pdd" @@ -701026,6 +703925,10 @@ "sim":259.0, "partner":"7pdh" }, + { + "sim":259.0, + "partner":"7pd8" + }, { "sim":254.0, "partner":"6fp8" @@ -701166,30 +704069,18 @@ "sim":208.0, "partner":"5aq9" }, - { - "sim":207.0, - "partner":"7yz0" - }, { "sim":207.0, "partner":"6mzf" }, { "sim":207.0, - "partner":"7yz1" - }, - { - "sim":207.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":207.0, "partner":"5nqt" }, - { - "sim":207.0, - "partner":"6mze" - }, { "sim":207.0, "partner":"7yz2" @@ -701200,11 +704091,11 @@ }, { "sim":207.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":207.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":207.0, @@ -701216,23 +704107,23 @@ }, { "sim":207.0, - "partner":"4lnu" + "partner":"7yz6" }, { "sim":207.0, - "partner":"7yz6" + "partner":"4lnu" }, { "sim":207.0, - "partner":"4drx" + "partner":"6zwb" }, { "sim":207.0, - "partner":"5nm5" + "partner":"4drx" }, { "sim":207.0, - "partner":"6zwb" + "partner":"5nm5" }, { "sim":207.0, @@ -701246,17 +704137,29 @@ "sim":207.0, "partner":"7yyz" }, + { + "sim":207.0, + "partner":"7yz0" + }, + { + "sim":207.0, + "partner":"7yz1" + }, + { + "sim":207.0, + "partner":"7z01" + }, { "sim":206.0, "partner":"8p9d" }, { "sim":206.0, - "partner":"5oyj" + "partner":"6gvm" }, { "sim":206.0, - "partner":"6gvm" + "partner":"5oyj" }, { "sim":206.0, @@ -701268,27 +704171,19 @@ }, { "sim":205.0, - "partner":"5eno" - }, - { - "sim":205.0, - "partner":"6zob" - }, - { - "sim":205.0, - "partner":"6zo5" + "partner":"4dx6" }, { "sim":205.0, - "partner":"4dx6" + "partner":"4ydy" }, { "sim":205.0, - "partner":"4ydy" + "partner":"6sgs" }, { "sim":205.0, - "partner":"6q4n" + "partner":"6zoc" }, { "sim":205.0, @@ -701296,7 +704191,7 @@ }, { "sim":205.0, - "partner":"6zoc" + "partner":"6zo6" }, { "sim":205.0, @@ -701304,19 +704199,19 @@ }, { "sim":205.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":205.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":205.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":205.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":205.0, @@ -701324,11 +704219,7 @@ }, { "sim":205.0, - "partner":"6zod" - }, - { - "sim":205.0, - "partner":"7b8r" + "partner":"6zo7" }, { "sim":205.0, @@ -701336,23 +704227,23 @@ }, { "sim":205.0, - "partner":"5enq" + "partner":"6zoe" }, { "sim":205.0, - "partner":"6zo7" + "partner":"5enq" }, { "sim":205.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":205.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":205.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":205.0, @@ -701368,19 +704259,19 @@ }, { "sim":205.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":205.0, - "partner":"3noc" + "partner":"6zof" }, { "sim":205.0, - "partner":"6zo8" + "partner":"3noc" }, { "sim":205.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":205.0, @@ -701388,19 +704279,15 @@ }, { "sim":205.0, - "partner":"4u8v" - }, - { - "sim":205.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":205.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":205.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":205.0, @@ -701412,11 +704299,11 @@ }, { "sim":205.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":205.0, - "partner":"5ens" + "partner":"6gvn" }, { "sim":205.0, @@ -701424,28 +704311,32 @@ }, { "sim":205.0, - "partner":"5en5" + "partner":"5ens" }, { "sim":205.0, - "partner":"6gvn" + "partner":"5en5" }, { "sim":205.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":205.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":205.0, - "partner":"6zoh" + "partner":"4u8y" }, { "sim":205.0, "partner":"3nog" }, + { + "sim":205.0, + "partner":"6sgr" + }, { "sim":205.0, "partner":"4c48" @@ -701460,12 +704351,24 @@ }, { "sim":205.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":205.0, "partner":"4dx5" }, + { + "sim":205.0, + "partner":"5eno" + }, + { + "sim":205.0, + "partner":"6zo5" + }, + { + "sim":205.0, + "partner":"6q4n" + }, { "sim":204.0, "partner":"5eib" @@ -701528,11 +704431,11 @@ }, { "sim":199.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":199.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":199.0, @@ -701604,11 +704507,11 @@ }, { "sim":194.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":194.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":193.0, @@ -701664,11 +704567,11 @@ }, { "sim":184.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":184.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":183.0, @@ -701774,17 +704677,13 @@ "sim":175.0, "partner":"8g4e" }, - { - "sim":173.0, - "partner":"3q9n" - }, { "sim":173.0, "partner":"3q9u" }, { "sim":173.0, - "partner":"8g4f" + "partner":"3q9n" }, { "sim":173.0, @@ -701803,13 +704702,17 @@ "partner":"8g3k" }, { - "sim":171.0, - "partner":"6mog" + "sim":173.0, + "partner":"8g4f" }, { "sim":171.0, "partner":"6moh" }, + { + "sim":171.0, + "partner":"6mog" + }, { "sim":170.0, "partner":"7p3i" @@ -701864,23 +704767,23 @@ }, { "sim":94.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":94.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":94.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":94.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":94.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":94.0, @@ -701888,11 +704791,11 @@ }, { "sim":94.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":94.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":94.0, @@ -701982,10 +704885,6 @@ "sim":90.0, "partner":"4rlv" }, - { - "sim":89.0, - "partner":"5vhj" - }, { "sim":89.0, "partner":"5vhh" @@ -702016,15 +704915,15 @@ }, { "sim":89.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":89.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":89.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":89.0, @@ -702034,6 +704933,10 @@ "sim":89.0, "partner":"7vxw" }, + { + "sim":89.0, + "partner":"1uoh" + }, { "sim":89.0, "partner":"7vy4" @@ -702044,11 +704947,11 @@ }, { "sim":89.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":89.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":89.0, @@ -702104,11 +705007,11 @@ }, { "sim":84.0, - "partner":"1g3n" + "partner":"5eid" }, { "sim":84.0, - "partner":"5eid" + "partner":"1g3n" }, { "sim":83.0, @@ -702192,19 +705095,19 @@ }, { "sim":80.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":80.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":80.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":80.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":80.0, @@ -702224,11 +705127,11 @@ }, { "sim":77.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":77.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":77.0, @@ -702396,15 +705299,15 @@ }, { "sim":71.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":71.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":71.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":71.0, @@ -702468,11 +705371,11 @@ }, { "sim":69.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":69.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":69.0, @@ -702550,10 +705453,6 @@ "sim":66.0, "partner":"5et0" }, - { - "sim":66.0, - "partner":"6v9x" - }, { "sim":66.0, "partner":"6v9y" @@ -702566,6 +705465,10 @@ "sim":66.0, "partner":"6v9w" }, + { + "sim":66.0, + "partner":"6v9x" + }, { "sim":66.0, "partner":"7or0" @@ -702634,14 +705537,6 @@ "sim":65.0, "partner":"4oav" }, - { - "sim":65.0, - "partner":"6m11" - }, - { - "sim":65.0, - "partner":"6m12" - }, { "sim":65.0, "partner":"6m13" @@ -702666,6 +705561,14 @@ "sim":65.0, "partner":"4o1p" }, + { + "sim":65.0, + "partner":"6m11" + }, + { + "sim":65.0, + "partner":"6m12" + }, { "sim":64.0, "partner":"1oy3" @@ -702748,11 +705651,11 @@ }, { "sim":59.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":59.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":59.0, @@ -702778,10 +705681,6 @@ "sim":54.0, "partner":"5wo6" }, - { - "sim":54.0, - "partner":"5iwr" - }, { "sim":54.0, "partner":"5iwt" @@ -702836,11 +705735,11 @@ }, { "sim":54.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":54.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":54.0, @@ -702880,7 +705779,7 @@ }, { "sim":54.0, - "partner":"7t6m" + "partner":"6o1p" }, { "sim":54.0, @@ -702926,6 +705825,10 @@ "sim":54.0, "partner":"7t6l" }, + { + "sim":54.0, + "partner":"7t6m" + }, { "sim":53.0, "partner":"2rfa" @@ -703013,7 +705916,7 @@ }, "seq_max_sim_natural":{ "sim":259.0, - "partner":"7pd8" + "partner":"7pdd" }, "struct_max_sim_designed":{ "sim":0.9625999928, @@ -703111,77 +706014,77 @@ "structure from cyana 2.1" ], "keywords":[ - "series", - "consisting", - "obtained", - "amphipathic", "induce", + "fluorescence", + "simulations", + "hemolytic", + "introducing", "molecular", - "topology", - "propensity", - "studies", - "membrane", - "herein", - "exhibited", + "revealed", "ht2", - "also", - "antimicrobial", - "study", - "report", - "potent", - "strategy", - "rational", - "class", - "increasing", - "experiments", - "peptide", - "increased", - "optimization", - "peptides", - "antibiotics", - "number", - "dramatically", - "head", + "aromatic", + "mechanisms", "indeed", + "structural", + "design", + "topology", + "number", + "exhibited", "analogs", - "electron", - "aromatic", + "rational", + "arg", + "consisting", "residues", - "confirmed", "targeting", + "lead", + "report", + "progressive", "provide", - "tail", - "alternatives", - "activity", - "two", - "simulations", - "discovery", + "experiments", + "herein", "rearranging", - "progressive", - "design", - "dynamics", + "also", + "new", + "strategy", + "novel", + "antibiotics", + "nmr", + "adopted", + "study", + "optimization", + "increased", "cytotoxicity", - "lead", - "microscopy", + "activities", + "alternatives", + "membrane", + "propensity", + "class", + "head", "resistance", - "mechanisms", - "nmr", + "electron", + "sar", + "dramatically", + "microscopy", + "series", + "confirmed", "promising", - "activities", - "revealed", - "relationship", - "ultrashort", - "introducing", - "hemolytic", - "fluorescence", - "adopted", - "novel", + "activity", + "peptides", "conventional", + "relationship", + "tail", "conformations", - "structural", - "arg", - "sar", - "new" + "two", + "studies", + "discovery", + "potent", + "ultrashort", + "antimicrobial", + "amphipathic", + "increasing", + "peptide", + "dynamics", + "obtained" ], "release_date":"2023-10-25", "publication":"\"Design and evaluation of tadpole-like conformational antimicrobial peptides\", Commun Biol, 6, 1177-1177", @@ -703311,104 +706214,104 @@ "a computational design mutant of a fusion protein from the c terminal of 4.1g and numa" ], "keywords":[ - "domain", - "analysis", - "results", - "thus", + "complementarity", + "recognition", + "structural", + "learning", + "resolution", + "number", + "show", + "key", + "experimental", "complexes", + "intrinsically", + "core", + "combining", + "results", + "scanning", + "folding", + "protein", + "across", + "essential", + "domains", + "af2", + "numa", + "region", + "crystal", "assessment", - "increasing", - "conserved", + "corresponding", + "using", + "uncover", + "deep", + "complex", + "performing", "jointly", - "prediction", - "uses", + "dynamic", + "mechanisms", + "formed", + "thus", + "residues", + "targets", + "dihydrofolate", + "proteins", + "mutants", + "experiment", "broad", - "crystal", - "potential", - "target", - "mostly", - "show", - "based", + "highly", + "found", + "elusive", + "mutant", + "computational", "regions", - "interactions", - "idps", - "module", + "design", "dissected", - "structure", - "recently", - "applied", - "consistent", + "moreover", + "segregate", + "idp", + "domain", + "potential", + "otherwise", + "experiments", + "prediction", + "disordered", + "carry", "interaction", - "synergistic", - "combining", - "ctd", - "proteins", - "challenges", - "numa", + "predicted", + "sequence", + "applied", + "idps", "solved", + "uses", + "developed", + "method", + "increasing", + "mostly", + "reveal", + "alphafold2", + "analysis", "presents", - "number", - "highly", - "recognition", - "experiment", - "dynamic", - "disordered", - "corresponding", - "essential", - "mutants", + "one", + "indicate", + "conserved", + "true", + "mutational", + "ctd", + "approaches", "first", - "intrinsically", - "alphafold2", - "complementarity", "detailed", - "resolution", - "scanning", - "identify", - "method", - "moreover", - "mutant", - "approaches", - "region", - "true", - "design", - "elusive", - "dihydrofolate", - "core", + "based", + "structure", + "module", + "challenges", + "target", + "recently", "recognize", - "using", - "across", - "high", - "sequence", - "indicate", - "key", - "learning", - "otherwise", - "structural", - "predicted", - "one", - "mutational", - "experiments", - "experimental", - "carry", - "residues", - "reveal", - "found", + "interactions", + "synergistic", "systematic", - "domains", - "uncover", - "performing", - "protein", - "idp", - "targets", - "mechanisms", - "complex", - "segregate", - "computational", - "deep", - "folding", - "developed", - "formed", - "af2" + "identify", + "high", + "consistent" ], "release_date":"2023-04-19", "publication":"\"Combined prediction and design reveals the target recognition mechanism of an intrinsically disordered protein interaction domain\", Proc.Natl.Acad.Sci.USA, 120, e2305603120-e2305603120", @@ -703544,90 +706447,90 @@ ], "subtitle":"A near-infrared fluorescent protein of de novo backbone design", "tags":[ - "de novo backbone design", "monomerization", "de novo protein", - "near-infrared fluorescent protein" + "near-infrared fluorescent protein", + "de novo backbone design" ], "keywords":[ - "evolution", - "monomeric", - "use", - "imaging", + "molecular", + "shield", + "nir", + "13", + "fluorescent", + "new", "strategy", - "place", - "designed", + "protein", + "binding", + "weight", + "confirmed", + "apo", + "forms", + "systems", "potentially", - "experimentally", - "crystal", - "dmsmurfp", - "determined", - "based", - "enhanced", - "structure", - "applied", - "monomerize", - "fluorescence", - "biliverdin", "original", - "chain", - "proteins", - "employed", - "characterized", - "covering", - "kda", - "small", - "interface", - "used", "intersubunit", + "two", + "crystal", + "weak", + "stable", "binds", - "smurfp", - "structures", - "naturally", - "mammalian", - "suitable", - "second", - "multimeric", - "systems", + "helices", + "complex", + "characterized", + "dimer", + "experimentally", + "monomerize", + "place", + "covering", + "proteins", + "sites", "rounds", - "fluorescent", + "use", + "segment", + "biliverdin", + "interface", + "small", + "evolution", "obtained", - "molecular", - "demonstrated", - "functional", - "bright", - "engineer", - "dimer", - "fp", - "apo", + "pocket", + "mammalian", "design", - "weight", - "weak", - "nir", - "segment", - "13", - "sites", - "designs", - "helices", + "enhanced", + "chain", + "used", + "functional", + "dmsmurfp", "also", - "stable", - "directed", - "confirmed", - "two", - "state", - "protein", - "shield", - "complex", + "kda", "backbone", - "bioimaging", - "extend", + "applied", + "demonstrated", "chromophore", - "ultrared", + "engineer", + "fluorescence", + "designed", + "employed", + "directed", + "naturally", "vivo", - "pocket", - "binding", - "forms", - "new" + "structures", + "fp", + "suitable", + "smurfp", + "imaging", + "based", + "structure", + "monomeric", + "determined", + "bioimaging", + "multimeric", + "state", + "bright", + "ultrared", + "extend", + "second", + "designs" ], "release_date":"2023-10-04", "publication":"\"Using Protein Design and Directed Evolution to Monomerize a Bright Near-Infrared Fluorescent Protein\", Acs Synth Biol, 13, 1177-1190", @@ -703660,11 +706563,11 @@ "seq_thr_sim_designed":[ { "sim":428.0, - "partner":"8j1x" + "partner":"8j98" }, { "sim":428.0, - "partner":"8j98" + "partner":"8j1x" }, { "sim":370.0, @@ -703676,11 +706579,11 @@ }, { "sim":77.0, - "partner":"8jpa" + "partner":"8hdv" }, { "sim":77.0, - "partner":"8hdv" + "partner":"8jpa" }, { "sim":74.0, @@ -703700,7 +706603,7 @@ }, { "sim":51.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":51.0, @@ -703708,15 +706611,15 @@ }, { "sim":51.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":51.0, - "partner":"8w08" + "partner":"8w06" }, { "sim":51.0, - "partner":"8w05" + "partner":"8v0a" }, { "sim":51.0, @@ -703724,11 +706627,11 @@ }, { "sim":50.0, - "partner":"8v2w" + "partner":"8v09" }, { "sim":50.0, - "partner":"8v09" + "partner":"8v2w" } ], "seq_thr_sim_natural":[ @@ -703754,15 +706657,15 @@ }, { "sim":138.0, - "partner":"7sc9" + "partner":"7sc7" }, { "sim":138.0, - "partner":"7sc7" + "partner":"7scb" }, { "sim":138.0, - "partner":"7scb" + "partner":"7sc9" }, { "sim":136.0, @@ -703770,23 +706673,23 @@ }, { "sim":134.0, - "partner":"6kgx" + "partner":"7ezx" }, { "sim":134.0, - "partner":"7y7a" + "partner":"7y4l" }, { "sim":134.0, - "partner":"7ezx" + "partner":"7y5e" }, { "sim":134.0, - "partner":"7y4l" + "partner":"6kgx" }, { "sim":134.0, - "partner":"7y5e" + "partner":"7y7a" }, { "sim":133.0, @@ -703920,10 +706823,6 @@ "sim":75.0, "partner":"3roj" }, - { - "sim":75.0, - "partner":"3nc3" - }, { "sim":75.0, "partner":"3nc5" @@ -703936,6 +706835,10 @@ "sim":75.0, "partner":"3nc7" }, + { + "sim":75.0, + "partner":"3nc3" + }, { "sim":74.0, "partner":"2kg1" @@ -703956,18 +706859,6 @@ "sim":74.0, "partner":"3s2s" }, - { - "sim":74.0, - "partner":"7ex2" - }, - { - "sim":74.0, - "partner":"7ex3" - }, - { - "sim":74.0, - "partner":"7ex4" - }, { "sim":74.0, "partner":"7ex6" @@ -704016,6 +706907,18 @@ "sim":74.0, "partner":"7ex1" }, + { + "sim":74.0, + "partner":"7ex2" + }, + { + "sim":74.0, + "partner":"7ex3" + }, + { + "sim":74.0, + "partner":"7ex4" + }, { "sim":74.0, "partner":"5u4z" @@ -704152,10 +707055,6 @@ "sim":73.0, "partner":"6wyn" }, - { - "sim":73.0, - "partner":"7dw8" - }, { "sim":73.0, "partner":"7dwa" @@ -704174,15 +707073,15 @@ }, { "sim":73.0, - "partner":"4y0x" + "partner":"7dw8" }, { "sim":73.0, - "partner":"4y12" + "partner":"4y0x" }, { "sim":73.0, - "partner":"6jtl" + "partner":"4y12" }, { "sim":73.0, @@ -704198,19 +707097,19 @@ }, { "sim":73.0, - "partner":"4lit" + "partner":"6jtl" }, { "sim":73.0, - "partner":"4liu" + "partner":"4lit" }, { "sim":73.0, - "partner":"4liv" + "partner":"4liu" }, { "sim":73.0, - "partner":"3pln" + "partner":"4liv" }, { "sim":73.0, @@ -704224,6 +707123,10 @@ "sim":73.0, "partner":"3pjg" }, + { + "sim":73.0, + "partner":"3pln" + }, { "sim":73.0, "partner":"5gvx" @@ -704262,28 +707165,20 @@ }, { "sim":73.0, - "partner":"6unz" - }, - { - "sim":73.0, - "partner":"6uoj" + "partner":"6msn" }, { "sim":73.0, - "partner":"6upo" + "partner":"6unz" }, { "sim":73.0, - "partner":"6msn" + "partner":"6uq8" }, { "sim":73.0, "partner":"5l2r" }, - { - "sim":73.0, - "partner":"6uq8" - }, { "sim":73.0, "partner":"6uo0" @@ -704320,17 +707215,25 @@ "sim":73.0, "partner":"6up9" }, + { + "sim":73.0, + "partner":"6uoj" + }, + { + "sim":73.0, + "partner":"6upo" + }, { "sim":72.0, "partner":"6hrk" }, { "sim":72.0, - "partner":"6isk" + "partner":"6isl" }, { "sim":72.0, - "partner":"6isl" + "partner":"6isk" }, { "sim":72.0, @@ -704416,10 +707319,6 @@ "sim":72.0, "partner":"3wg8" }, - { - "sim":72.0, - "partner":"2uxx" - }, { "sim":72.0, "partner":"2iw5" @@ -704432,6 +707331,10 @@ "sim":72.0, "partner":"4kum" }, + { + "sim":72.0, + "partner":"2uxx" + }, { "sim":72.0, "partner":"7vxo" @@ -704508,10 +707411,6 @@ "sim":72.0, "partner":"6ddn" }, - { - "sim":72.0, - "partner":"3tro" - }, { "sim":72.0, "partner":"3tjx" @@ -704524,6 +707423,10 @@ "sim":72.0, "partner":"7myd" }, + { + "sim":72.0, + "partner":"3tro" + }, { "sim":72.0, "partner":"7m4s" @@ -704550,27 +707453,27 @@ }, { "sim":72.0, - "partner":"6alm" + "partner":"6alo" }, { "sim":72.0, - "partner":"6aln" + "partner":"6alp" }, { "sim":72.0, - "partner":"6alo" + "partner":"6alq" }, { "sim":72.0, - "partner":"6alp" + "partner":"6alr" }, { "sim":72.0, - "partner":"6alq" + "partner":"6alm" }, { "sim":72.0, - "partner":"6alr" + "partner":"6aln" }, { "sim":72.0, @@ -704638,11 +707541,11 @@ }, { "sim":72.0, - "partner":"4nxl" + "partner":"4jek" }, { "sim":72.0, - "partner":"4jek" + "partner":"4nxl" }, { "sim":72.0, @@ -704676,6 +707579,18 @@ "sim":72.0, "partner":"6lkc" }, + { + "sim":72.0, + "partner":"8vjq" + }, + { + "sim":72.0, + "partner":"8vix" + }, + { + "sim":72.0, + "partner":"8vh0" + }, { "sim":72.0, "partner":"6jym" @@ -704746,11 +707661,11 @@ }, { "sim":71.0, - "partner":"6mwy" + "partner":"6myl" }, { "sim":71.0, - "partner":"6myl" + "partner":"6mwy" }, { "sim":71.0, @@ -704778,11 +707693,11 @@ }, { "sim":71.0, - "partner":"3la8" + "partner":"3lba" }, { "sim":71.0, - "partner":"3lba" + "partner":"3la8" }, { "sim":71.0, @@ -704874,23 +707789,23 @@ }, { "sim":71.0, - "partner":"7ffg" + "partner":"7ffi" }, { "sim":71.0, - "partner":"7ffh" + "partner":"7ffa" }, { "sim":71.0, - "partner":"7ffi" + "partner":"7ffc" }, { "sim":71.0, - "partner":"7ffa" + "partner":"7ffg" }, { "sim":71.0, - "partner":"7ffc" + "partner":"7ffh" }, { "sim":71.0, @@ -704934,11 +707849,11 @@ }, { "sim":71.0, - "partner":"3l7r" + "partner":"3t0c" }, { "sim":71.0, - "partner":"3t0c" + "partner":"3l7r" }, { "sim":70.0, @@ -704976,10 +707891,6 @@ "sim":70.0, "partner":"3l1n" }, - { - "sim":70.0, - "partner":"4m02" - }, { "sim":70.0, "partner":"3zez" @@ -705016,6 +707927,10 @@ "sim":70.0, "partner":"5ffa" }, + { + "sim":70.0, + "partner":"4m02" + }, { "sim":70.0, "partner":"4e2a" @@ -705030,11 +707945,11 @@ }, { "sim":70.0, - "partner":"5nbt" + "partner":"6gzc" }, { "sim":70.0, - "partner":"6gzc" + "partner":"5nbt" }, { "sim":70.0, @@ -705060,10 +707975,6 @@ "sim":70.0, "partner":"4nod" }, - { - "sim":70.0, - "partner":"5nbh" - }, { "sim":70.0, "partner":"5n8d" @@ -705076,6 +707987,10 @@ "sim":70.0, "partner":"5n83" }, + { + "sim":70.0, + "partner":"5nbh" + }, { "sim":70.0, "partner":"3l87" @@ -705124,10 +708039,6 @@ "sim":70.0, "partner":"5ywt" }, - { - "sim":70.0, - "partner":"7eny" - }, { "sim":70.0, "partner":"8hp5" @@ -705142,19 +708053,23 @@ }, { "sim":70.0, - "partner":"5feu" + "partner":"7eny" }, { "sim":70.0, - "partner":"6pei" + "partner":"6pej" }, { "sim":70.0, - "partner":"6pej" + "partner":"6y4d" }, { "sim":70.0, - "partner":"6y4d" + "partner":"6pei" + }, + { + "sim":70.0, + "partner":"5feu" }, { "sim":70.0, @@ -705176,10 +708091,6 @@ "sim":70.0, "partner":"3b3d" }, - { - "sim":70.0, - "partner":"5yoi" - }, { "sim":70.0, "partner":"5ypj" @@ -705196,6 +708107,10 @@ "sim":70.0, "partner":"5yoh" }, + { + "sim":70.0, + "partner":"5yoi" + }, { "sim":70.0, "partner":"3p2m" @@ -705242,15 +708157,11 @@ }, { "sim":70.0, - "partner":"7cm8" - }, - { - "sim":70.0, - "partner":"7djq" + "partner":"7c35" }, { "sim":70.0, - "partner":"7c35" + "partner":"7ewo" }, { "sim":70.0, @@ -705266,12 +708177,16 @@ }, { "sim":70.0, - "partner":"7ewo" + "partner":"7cm8" }, { "sim":70.0, "partner":"5xcp" }, + { + "sim":70.0, + "partner":"7djq" + }, { "sim":70.0, "partner":"7cd5" @@ -705338,15 +708253,15 @@ }, { "sim":70.0, - "partner":"8uen" + "partner":"8uro" }, { "sim":70.0, - "partner":"8ura" + "partner":"8uen" }, { "sim":70.0, - "partner":"8uro" + "partner":"8ura" }, { "sim":70.0, @@ -705472,10 +708387,6 @@ "sim":69.0, "partner":"4jbh" }, - { - "sim":69.0, - "partner":"7q9z" - }, { "sim":69.0, "partner":"3udz" @@ -705498,15 +708409,15 @@ }, { "sim":69.0, - "partner":"5e0o" + "partner":"7q9z" }, { "sim":69.0, - "partner":"4e85" + "partner":"5e0o" }, { - "sim":68.0, - "partner":"3ul6" + "sim":69.0, + "partner":"4e85" }, { "sim":68.0, @@ -705514,7 +708425,7 @@ }, { "sim":68.0, - "partner":"4d1f" + "partner":"3ul6" }, { "sim":68.0, @@ -705524,6 +708435,10 @@ "sim":68.0, "partner":"4d0u" }, + { + "sim":68.0, + "partner":"4d1f" + }, { "sim":68.0, "partner":"5fld" @@ -705548,10 +708463,6 @@ "sim":68.0, "partner":"5zi0" }, - { - "sim":68.0, - "partner":"2zbb" - }, { "sim":68.0, "partner":"3e4o" @@ -705564,6 +708475,10 @@ "sim":68.0, "partner":"3e4q" }, + { + "sim":68.0, + "partner":"2zbb" + }, { "sim":68.0, "partner":"4nv7" @@ -705676,26 +708591,18 @@ "sim":67.0, "partner":"4f6l" }, - { - "sim":67.0, - "partner":"4bzc" - }, { "sim":67.0, "partner":"4qg1" }, { "sim":67.0, - "partner":"6dwk" + "partner":"6dwd" }, { "sim":67.0, "partner":"4qg2" }, - { - "sim":67.0, - "partner":"6dwd" - }, { "sim":67.0, "partner":"7s2y" @@ -705744,6 +708651,14 @@ "sim":67.0, "partner":"4qg0" }, + { + "sim":67.0, + "partner":"6dwk" + }, + { + "sim":67.0, + "partner":"4bzc" + }, { "sim":67.0, "partner":"8hhe" @@ -705770,15 +708685,15 @@ }, { "sim":65.0, - "partner":"2c7j" + "partner":"2c7k" }, { "sim":65.0, - "partner":"2c7k" + "partner":"2c7l" }, { "sim":65.0, - "partner":"2c7l" + "partner":"2c7j" }, { "sim":64.0, @@ -705822,11 +708737,11 @@ }, { "sim":62.0, - "partner":"2vml" + "partner":"2vjr" }, { "sim":62.0, - "partner":"2vjr" + "partner":"2vml" }, { "sim":62.0, @@ -705858,11 +708773,11 @@ }, { "sim":61.0, - "partner":"7d6w" + "partner":"1gh0" }, { "sim":61.0, - "partner":"1gh0" + "partner":"7d6w" }, { "sim":61.0, @@ -705880,10 +708795,6 @@ "sim":61.0, "partner":"2ium" }, - { - "sim":60.0, - "partner":"2uul" - }, { "sim":60.0, "partner":"7sc8" @@ -705897,20 +708808,16 @@ "partner":"4f0t" }, { - "sim":59.0, - "partner":"6ypq" - }, - { - "sim":59.0, - "partner":"7veb" + "sim":60.0, + "partner":"2uul" }, { "sim":59.0, - "partner":"4gy3" + "partner":"7eh7" }, { "sim":59.0, - "partner":"4n6s" + "partner":"7veb" }, { "sim":59.0, @@ -705922,11 +708829,11 @@ }, { "sim":59.0, - "partner":"1i7y" + "partner":"7efv" }, { "sim":59.0, - "partner":"7eh7" + "partner":"7s50" }, { "sim":59.0, @@ -705934,27 +708841,23 @@ }, { "sim":59.0, - "partner":"7s50" + "partner":"1i7y" }, { "sim":59.0, - "partner":"1jbo" + "partner":"8fwa" }, { "sim":59.0, "partner":"4gxe" }, - { - "sim":59.0, - "partner":"7efv" - }, { "sim":59.0, "partner":"1ktp" }, { "sim":59.0, - "partner":"8fwa" + "partner":"1jbo" }, { "sim":59.0, @@ -705962,27 +708865,27 @@ }, { "sim":59.0, - "partner":"1phn" + "partner":"6yqg" }, { "sim":59.0, - "partner":"6yqg" + "partner":"7efw" }, { "sim":59.0, - "partner":"4ziz" + "partner":"1phn" }, { "sim":59.0, - "partner":"1ha7" + "partner":"4ziz" }, { "sim":59.0, - "partner":"1on7" + "partner":"7eh8" }, { "sim":59.0, - "partner":"7efw" + "partner":"1on7" }, { "sim":59.0, @@ -705990,7 +708893,7 @@ }, { "sim":59.0, - "partner":"7eh8" + "partner":"1ha7" }, { "sim":59.0, @@ -706002,11 +708905,11 @@ }, { "sim":59.0, - "partner":"3o18" + "partner":"6yyj" }, { "sim":59.0, - "partner":"6yyj" + "partner":"3o18" }, { "sim":59.0, @@ -706020,13 +708923,25 @@ "sim":59.0, "partner":"5mjq" }, + { + "sim":59.0, + "partner":"6yq8" + }, { "sim":59.0, "partner":"5o7m" }, { "sim":59.0, - "partner":"6yq8" + "partner":"6ypq" + }, + { + "sim":59.0, + "partner":"4gy3" + }, + { + "sim":59.0, + "partner":"4n6s" }, { "sim":59.0, @@ -706042,15 +708957,15 @@ }, { "sim":58.0, - "partner":"6y3d" + "partner":"6xwk" }, { "sim":58.0, - "partner":"6xwk" + "partner":"4l1e" }, { "sim":58.0, - "partner":"4l1e" + "partner":"6y3d" }, { "sim":58.0, @@ -706070,11 +708985,11 @@ }, { "sim":58.0, - "partner":"4mdo" + "partner":"4mdp" }, { "sim":58.0, - "partner":"4mdp" + "partner":"4mdo" }, { "sim":58.0, @@ -706174,7 +709089,7 @@ }, { "sim":56.0, - "partner":"4lm6" + "partner":"7tlf" }, { "sim":56.0, @@ -706182,7 +709097,7 @@ }, { "sim":56.0, - "partner":"7tlf" + "partner":"4lm6" }, { "sim":56.0, @@ -706314,15 +709229,15 @@ }, { "sim":55.0, - "partner":"4bmx" + "partner":"4bmz" }, { "sim":55.0, - "partner":"4bmy" + "partner":"4bmx" }, { "sim":55.0, - "partner":"4bmz" + "partner":"4bmy" }, { "sim":55.0, @@ -706330,11 +709245,11 @@ }, { "sim":55.0, - "partner":"4jqc" + "partner":"4jx8" }, { "sim":55.0, - "partner":"4jx8" + "partner":"4jqc" }, { "sim":55.0, @@ -706344,10 +709259,6 @@ "sim":55.0, "partner":"5ita" }, - { - "sim":55.0, - "partner":"7drp" - }, { "sim":55.0, "partner":"7drm" @@ -706362,23 +709273,19 @@ }, { "sim":55.0, - "partner":"4rl1" - }, - { - "sim":55.0, - "partner":"8t0w" + "partner":"7drp" }, { "sim":55.0, - "partner":"8t0u" + "partner":"4rl1" }, { "sim":55.0, - "partner":"3dyh" + "partner":"8t0w" }, { "sim":55.0, - "partner":"4rxd" + "partner":"8t0u" }, { "sim":55.0, @@ -706422,48 +709329,40 @@ }, { "sim":55.0, - "partner":"2gqn" - }, - { - "sim":55.0, - "partner":"2fq6" + "partner":"4rxd" }, { "sim":55.0, - "partner":"5jk8" + "partner":"3dyh" }, { "sim":55.0, - "partner":"5jk5" + "partner":"2fq6" }, { "sim":55.0, - "partner":"5jk6" + "partner":"2gqn" }, { "sim":55.0, - "partner":"4wya" + "partner":"5jk8" }, { "sim":55.0, - "partner":"4wyf" + "partner":"5jk5" }, { "sim":55.0, - "partner":"4cxq" + "partner":"5jk6" }, { "sim":55.0, - "partner":"5kgs" + "partner":"4cxr" }, { "sim":55.0, "partner":"4wyg" }, - { - "sim":55.0, - "partner":"4cxr" - }, { "sim":55.0, "partner":"4xjl" @@ -706528,10 +709427,26 @@ "sim":55.0, "partner":"3tfu" }, + { + "sim":55.0, + "partner":"4wya" + }, { "sim":55.0, "partner":"4wye" }, + { + "sim":55.0, + "partner":"4wyf" + }, + { + "sim":55.0, + "partner":"4cxq" + }, + { + "sim":55.0, + "partner":"5kgs" + }, { "sim":55.0, "partner":"7jrl" @@ -706562,15 +709477,15 @@ }, { "sim":54.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":54.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":54.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":54.0, @@ -706618,11 +709533,11 @@ }, { "sim":54.0, - "partner":"4f0v" + "partner":"4f0w" }, { "sim":54.0, - "partner":"4f0w" + "partner":"4f0v" }, { "sim":54.0, @@ -706632,10 +709547,6 @@ "sim":54.0, "partner":"4bn0" }, - { - "sim":54.0, - "partner":"6o98" - }, { "sim":54.0, "partner":"7jh2" @@ -706650,15 +709561,11 @@ }, { "sim":54.0, - "partner":"2per" - }, - { - "sim":54.0, - "partner":"7kqj" + "partner":"6o98" }, { "sim":54.0, - "partner":"6vqf" + "partner":"2per" }, { "sim":54.0, @@ -706704,6 +709611,14 @@ "sim":54.0, "partner":"7luk" }, + { + "sim":54.0, + "partner":"6vqf" + }, + { + "sim":54.0, + "partner":"7kqj" + }, { "sim":54.0, "partner":"3g9g" @@ -706728,10 +709643,6 @@ "sim":54.0, "partner":"3u3j" }, - { - "sim":54.0, - "partner":"3u3r" - }, { "sim":54.0, "partner":"3u3k" @@ -706744,6 +709655,10 @@ "sim":54.0, "partner":"3u3o" }, + { + "sim":54.0, + "partner":"3u3r" + }, { "sim":54.0, "partner":"4j51" @@ -706766,11 +709681,11 @@ }, { "sim":54.0, - "partner":"7js3" + "partner":"8g5w" }, { "sim":54.0, - "partner":"8g5w" + "partner":"7js3" }, { "sim":54.0, @@ -706786,11 +709701,11 @@ }, { "sim":54.0, - "partner":"6wa9" + "partner":"6wa6" }, { "sim":54.0, - "partner":"6wa6" + "partner":"6wa9" }, { "sim":54.0, @@ -706818,11 +709733,11 @@ }, { "sim":54.0, - "partner":"5dt7" + "partner":"5dt5" }, { "sim":54.0, - "partner":"5dt5" + "partner":"5dt7" }, { "sim":54.0, @@ -706922,19 +709837,19 @@ }, { "sim":53.0, - "partner":"8b9b" + "partner":"8b9a" }, { "sim":53.0, - "partner":"6skl" + "partner":"8b9c" }, { "sim":53.0, - "partner":"8b9a" + "partner":"8b9b" }, { "sim":53.0, - "partner":"8b9c" + "partner":"6skl" }, { "sim":53.0, @@ -706982,11 +709897,11 @@ }, { "sim":53.0, - "partner":"5tii" + "partner":"5thq" }, { "sim":53.0, - "partner":"5thq" + "partner":"5tii" }, { "sim":53.0, @@ -707008,10 +709923,6 @@ "sim":53.0, "partner":"3uic" }, - { - "sim":53.0, - "partner":"4j3f" - }, { "sim":53.0, "partner":"4j4t" @@ -707024,6 +709935,10 @@ "sim":53.0, "partner":"4j1n" }, + { + "sim":53.0, + "partner":"4j3f" + }, { "sim":53.0, "partner":"5hii" @@ -707050,19 +709965,19 @@ }, { "sim":53.0, - "partner":"7a61" + "partner":"8rwq" }, { "sim":53.0, - "partner":"5uj3" + "partner":"6mnp" }, { "sim":53.0, - "partner":"5uj4" + "partner":"8rwr" }, { "sim":53.0, - "partner":"6mnp" + "partner":"5uj3" }, { "sim":53.0, @@ -707070,7 +709985,11 @@ }, { "sim":53.0, - "partner":"5ul8" + "partner":"8rws" + }, + { + "sim":53.0, + "partner":"5uj4" }, { "sim":53.0, @@ -707084,6 +710003,10 @@ "sim":53.0, "partner":"6d17" }, + { + "sim":53.0, + "partner":"5ul8" + }, { "sim":53.0, "partner":"6d18" @@ -707138,15 +710061,15 @@ }, { "sim":53.0, - "partner":"8rwq" + "partner":"6mey" }, { "sim":53.0, - "partner":"6mey" + "partner":"6v1j" }, { "sim":53.0, - "partner":"6v1j" + "partner":"8aki" }, { "sim":53.0, @@ -707154,7 +710077,7 @@ }, { "sim":53.0, - "partner":"8aki" + "partner":"8akj" }, { "sim":53.0, @@ -707166,7 +710089,7 @@ }, { "sim":53.0, - "partner":"8akj" + "partner":"8akk" }, { "sim":53.0, @@ -707174,27 +710097,27 @@ }, { "sim":53.0, - "partner":"8akk" + "partner":"8akl" }, { "sim":53.0, - "partner":"8akl" + "partner":"8akm" }, { "sim":53.0, - "partner":"8akm" + "partner":"7a61" }, { "sim":53.0, - "partner":"6loi" + "partner":"8rwo" }, { "sim":53.0, - "partner":"3p8e" + "partner":"8rwp" }, { "sim":53.0, - "partner":"7ulx" + "partner":"6loi" }, { "sim":53.0, @@ -707228,6 +710151,14 @@ "sim":53.0, "partner":"2otn" }, + { + "sim":53.0, + "partner":"3p8e" + }, + { + "sim":53.0, + "partner":"7ulx" + }, { "sim":53.0, "partner":"3utn" @@ -707250,15 +710181,15 @@ }, { "sim":53.0, - "partner":"4w7v" + "partner":"4w7u" }, { "sim":53.0, - "partner":"4w7w" + "partner":"4w7v" }, { "sim":53.0, - "partner":"4w7u" + "partner":"4w7w" }, { "sim":53.0, @@ -707288,10 +710219,6 @@ "sim":53.0, "partner":"8bft" }, - { - "sim":53.0, - "partner":"7ajm" - }, { "sim":53.0, "partner":"7a4r" @@ -707306,31 +710233,15 @@ }, { "sim":53.0, - "partner":"7a19" - }, - { - "sim":53.0, - "partner":"7a1a" - }, - { - "sim":53.0, - "partner":"7a53" - }, - { - "sim":53.0, - "partner":"7ajw" - }, - { - "sim":53.0, - "partner":"7akb" + "partner":"7ajm" }, { "sim":53.0, - "partner":"7ajy" + "partner":"7a19" }, { "sim":53.0, - "partner":"7a5l" + "partner":"7a1a" }, { "sim":53.0, @@ -707392,17 +710303,33 @@ "sim":53.0, "partner":"7aka" }, + { + "sim":53.0, + "partner":"7a53" + }, { "sim":53.0, "partner":"7akl" }, { "sim":53.0, - "partner":"8tne" + "partner":"7ajw" }, { "sim":53.0, - "partner":"8ixa" + "partner":"7akb" + }, + { + "sim":53.0, + "partner":"7ajy" + }, + { + "sim":53.0, + "partner":"7a5l" + }, + { + "sim":53.0, + "partner":"8tne" }, { "sim":53.0, @@ -707424,6 +710351,10 @@ "sim":53.0, "partner":"8ixg" }, + { + "sim":53.0, + "partner":"8ixa" + }, { "sim":53.0, "partner":"7ugb" @@ -707458,11 +710389,11 @@ }, { "sim":53.0, - "partner":"4ak5" + "partner":"7k14" }, { "sim":53.0, - "partner":"7k14" + "partner":"4ak5" }, { "sim":53.0, @@ -707474,11 +710405,11 @@ }, { "sim":53.0, - "partner":"8hsv" + "partner":"8hst" }, { "sim":53.0, - "partner":"8hst" + "partner":"8hsv" }, { "sim":53.0, @@ -707534,11 +710465,11 @@ }, { "sim":53.0, - "partner":"6ak4" + "partner":"6aej" }, { "sim":53.0, - "partner":"6aej" + "partner":"6ak4" }, { "sim":53.0, @@ -707564,10 +710495,6 @@ "sim":53.0, "partner":"3khz" }, - { - "sim":53.0, - "partner":"4ie7" - }, { "sim":53.0, "partner":"4cxw" @@ -707586,15 +710513,15 @@ }, { "sim":53.0, - "partner":"4idz" + "partner":"7e8z" }, { "sim":53.0, - "partner":"4ie0" + "partner":"4idz" }, { "sim":53.0, - "partner":"7e8z" + "partner":"4ie0" }, { "sim":53.0, @@ -707614,15 +710541,15 @@ }, { "sim":53.0, - "partner":"7oze" + "partner":"4ie7" }, { "sim":53.0, - "partner":"7ozc" + "partner":"7oze" }, { "sim":53.0, - "partner":"2cj9" + "partner":"7ozc" }, { "sim":53.0, @@ -707636,6 +710563,10 @@ "sim":53.0, "partner":"2cjb" }, + { + "sim":53.0, + "partner":"2cj9" + }, { "sim":53.0, "partner":"6d23" @@ -707662,15 +710593,15 @@ }, { "sim":53.0, - "partner":"2vbg" + "partner":"2vbf" }, { "sim":53.0, - "partner":"2vbf" + "partner":"2vbg" }, { "sim":53.0, - "partner":"5m12" + "partner":"6gwg" }, { "sim":53.0, @@ -707678,31 +710609,31 @@ }, { "sim":53.0, - "partner":"6gwf" + "partner":"6gta" }, { "sim":53.0, - "partner":"6gwg" + "partner":"5m16" }, { "sim":53.0, - "partner":"5m16" + "partner":"6gvd" }, { "sim":53.0, - "partner":"6gta" + "partner":"5m0x" }, { "sim":53.0, - "partner":"6gvd" + "partner":"6gx8" }, { "sim":53.0, - "partner":"5m0x" + "partner":"5m12" }, { "sim":53.0, - "partner":"6gx8" + "partner":"6gwf" }, { "sim":53.0, @@ -707756,21 +710687,17 @@ "sim":53.0, "partner":"2bn4" }, - { - "sim":53.0, - "partner":"3o8y" - }, { "sim":53.0, "partner":"7ttj" }, { "sim":53.0, - "partner":"7ttk" + "partner":"6n2w" }, { "sim":53.0, - "partner":"6n2w" + "partner":"7ttk" }, { "sim":53.0, @@ -707794,11 +710721,7 @@ }, { "sim":53.0, - "partner":"7vzz" - }, - { - "sim":53.0, - "partner":"7vzu" + "partner":"3o8y" }, { "sim":53.0, @@ -707812,6 +710735,14 @@ "sim":53.0, "partner":"7vzy" }, + { + "sim":53.0, + "partner":"7vzz" + }, + { + "sim":53.0, + "partner":"7vzu" + }, { "sim":53.0, "partner":"5swi" @@ -707890,15 +710821,15 @@ }, { "sim":52.0, - "partner":"3qna" + "partner":"3qn0" }, { "sim":52.0, - "partner":"3qn0" + "partner":"3qn9" }, { "sim":52.0, - "partner":"3qn9" + "partner":"3qna" }, { "sim":52.0, @@ -707924,14 +710855,6 @@ "sim":52.0, "partner":"4lmx" }, - { - "sim":52.0, - "partner":"5scp" - }, - { - "sim":52.0, - "partner":"5scq" - }, { "sim":52.0, "partner":"5scr" @@ -708034,7 +710957,11 @@ }, { "sim":52.0, - "partner":"1x24" + "partner":"5scp" + }, + { + "sim":52.0, + "partner":"5scq" }, { "sim":52.0, @@ -708042,19 +710969,19 @@ }, { "sim":52.0, - "partner":"3rz2" + "partner":"1x24" }, { "sim":52.0, - "partner":"2x7m" + "partner":"3rz2" }, { "sim":52.0, - "partner":"2j8k" + "partner":"2x7m" }, { "sim":52.0, - "partner":"5l9k" + "partner":"2j8k" }, { "sim":52.0, @@ -708068,6 +710995,10 @@ "sim":52.0, "partner":"5lau" }, + { + "sim":52.0, + "partner":"5l9k" + }, { "sim":52.0, "partner":"4b29" @@ -708078,11 +711009,11 @@ }, { "sim":52.0, - "partner":"1wc6" + "partner":"1wc1" }, { "sim":52.0, - "partner":"1wc1" + "partner":"1wc6" }, { "sim":52.0, @@ -708132,14 +711063,6 @@ "sim":52.0, "partner":"5dtz" }, - { - "sim":52.0, - "partner":"6tlm" - }, - { - "sim":52.0, - "partner":"6tlq" - }, { "sim":52.0, "partner":"6tlt" @@ -708172,6 +711095,14 @@ "sim":52.0, "partner":"6t50" }, + { + "sim":52.0, + "partner":"6tlm" + }, + { + "sim":52.0, + "partner":"6tlq" + }, { "sim":52.0, "partner":"5du0" @@ -708226,39 +711157,39 @@ }, { "sim":52.0, - "partner":"3quo" + "partner":"3qur" }, { "sim":52.0, - "partner":"3qvf" + "partner":"4rnj" }, { "sim":52.0, - "partner":"4rni" + "partner":"3qvh" }, { "sim":52.0, - "partner":"4rnj" + "partner":"3d40" }, { "sim":52.0, - "partner":"3qur" + "partner":"3d41" }, { "sim":52.0, - "partner":"3qvh" + "partner":"3qun" }, { "sim":52.0, - "partner":"3d40" + "partner":"3quo" }, { "sim":52.0, - "partner":"3d41" + "partner":"3qvf" }, { "sim":52.0, - "partner":"3qun" + "partner":"4rni" }, { "sim":52.0, @@ -708286,11 +711217,11 @@ }, { "sim":52.0, - "partner":"5okt" + "partner":"7nzy" }, { "sim":52.0, - "partner":"7nzy" + "partner":"5okt" }, { "sim":52.0, @@ -708454,15 +711385,15 @@ }, { "sim":52.0, - "partner":"5v59" + "partner":"4xem" }, { "sim":52.0, - "partner":"4xem" + "partner":"4xeo" }, { "sim":52.0, - "partner":"4xeo" + "partner":"5v59" }, { "sim":52.0, @@ -708482,11 +711413,11 @@ }, { "sim":52.0, - "partner":"1zdl" + "partner":"1zkq" }, { "sim":52.0, - "partner":"1zkq" + "partner":"1zdl" }, { "sim":52.0, @@ -708494,15 +711425,15 @@ }, { "sim":52.0, - "partner":"5kdn" + "partner":"5kds" }, { "sim":52.0, - "partner":"5kds" + "partner":"5kdu" }, { "sim":52.0, - "partner":"5kdu" + "partner":"5kdn" }, { "sim":52.0, @@ -708578,15 +711509,15 @@ }, { "sim":52.0, - "partner":"6jr8" + "partner":"6jr6" }, { "sim":52.0, - "partner":"6jr6" + "partner":"6jr7" }, { "sim":52.0, - "partner":"6jr7" + "partner":"6jr8" }, { "sim":52.0, @@ -708656,10 +711587,6 @@ "sim":51.0, "partner":"6aq7" }, - { - "sim":51.0, - "partner":"4hmr" - }, { "sim":51.0, "partner":"6t3o" @@ -708672,6 +711599,10 @@ "sim":51.0, "partner":"4hmm" }, + { + "sim":51.0, + "partner":"4hmr" + }, { "sim":51.0, "partner":"6g61" @@ -708702,23 +711633,23 @@ }, { "sim":51.0, - "partner":"3d7j" + "partner":"4nns" }, { "sim":51.0, - "partner":"5y0f" + "partner":"4nnt" }, { "sim":51.0, - "partner":"5y0g" + "partner":"6ljs" }, { "sim":51.0, - "partner":"4nns" + "partner":"6ljt" }, { "sim":51.0, - "partner":"4nnt" + "partner":"6lyw" }, { "sim":51.0, @@ -708726,7 +711657,7 @@ }, { "sim":51.0, - "partner":"6ljs" + "partner":"6lju" }, { "sim":51.0, @@ -708736,18 +711667,6 @@ "sim":51.0, "partner":"5y13" }, - { - "sim":51.0, - "partner":"6ljt" - }, - { - "sim":51.0, - "partner":"6lyw" - }, - { - "sim":51.0, - "partner":"6lju" - }, { "sim":51.0, "partner":"6ljv" @@ -708780,25 +711699,33 @@ "sim":51.0, "partner":"3q6l" }, + { + "sim":51.0, + "partner":"3d7j" + }, { "sim":51.0, "partner":"5y0x" }, { "sim":51.0, - "partner":"6lyx" + "partner":"5y0f" }, { "sim":51.0, - "partner":"2bze" + "partner":"5y0g" }, { "sim":51.0, - "partner":"3wbg" + "partner":"6lyx" }, { "sim":51.0, - "partner":"5hso" + "partner":"2bze" + }, + { + "sim":51.0, + "partner":"3wbg" }, { "sim":51.0, @@ -708818,7 +711745,7 @@ }, { "sim":51.0, - "partner":"3sw1" + "partner":"5hso" }, { "sim":51.0, @@ -708842,11 +711769,11 @@ }, { "sim":51.0, - "partner":"7r4s" + "partner":"6gg9" }, { "sim":51.0, - "partner":"6gg9" + "partner":"7r4s" }, { "sim":51.0, @@ -708854,11 +711781,11 @@ }, { "sim":51.0, - "partner":"5luv" + "partner":"3sw1" }, { "sim":51.0, - "partner":"5aoz" + "partner":"5luv" }, { "sim":51.0, @@ -708868,6 +711795,10 @@ "sim":51.0, "partner":"3ph4" }, + { + "sim":51.0, + "partner":"5aoz" + }, { "sim":51.0, "partner":"4oja" @@ -708878,11 +711809,11 @@ }, { "sim":51.0, - "partner":"7xtl" + "partner":"3l7u" }, { "sim":51.0, - "partner":"3l7u" + "partner":"3l20" }, { "sim":51.0, @@ -708890,7 +711821,7 @@ }, { "sim":51.0, - "partner":"3l20" + "partner":"7xtl" }, { "sim":51.0, @@ -708934,11 +711865,11 @@ }, { "sim":51.0, - "partner":"4nsq" + "partner":"4f07" }, { "sim":51.0, - "partner":"4f07" + "partner":"4nsq" }, { "sim":51.0, @@ -708952,10 +711883,6 @@ "sim":51.0, "partner":"3p6b" }, - { - "sim":51.0, - "partner":"6f3z" - }, { "sim":51.0, "partner":"7q4s" @@ -708970,19 +711897,19 @@ }, { "sim":51.0, - "partner":"2d7j" + "partner":"6f3z" }, { "sim":51.0, - "partner":"6pj9" + "partner":"2d7j" }, { "sim":51.0, - "partner":"6pja" + "partner":"6pjp" }, { "sim":51.0, - "partner":"6pjp" + "partner":"6pjq" }, { "sim":51.0, @@ -708990,11 +711917,11 @@ }, { "sim":51.0, - "partner":"6pjq" + "partner":"6pjr" }, { "sim":51.0, - "partner":"6pjr" + "partner":"6pju" }, { "sim":51.0, @@ -709004,10 +711931,6 @@ "sim":51.0, "partner":"5f5d" }, - { - "sim":51.0, - "partner":"6pju" - }, { "sim":51.0, "partner":"4njp" @@ -709030,15 +711953,19 @@ }, { "sim":51.0, - "partner":"5f5j" + "partner":"6pj5" }, { "sim":51.0, - "partner":"6pj5" + "partner":"6pj7" }, { "sim":51.0, - "partner":"6pj7" + "partner":"5f5j" + }, + { + "sim":51.0, + "partner":"6pj8" }, { "sim":51.0, @@ -709046,7 +711973,11 @@ }, { "sim":51.0, - "partner":"6pj8" + "partner":"6pj9" + }, + { + "sim":51.0, + "partner":"6pja" }, { "sim":51.0, @@ -709086,15 +712017,15 @@ }, { "sim":51.0, - "partner":"6j0l" + "partner":"6j0g" }, { "sim":51.0, - "partner":"6j0g" + "partner":"6j0k" }, { "sim":51.0, - "partner":"6j0k" + "partner":"6j0l" }, { "sim":51.0, @@ -709118,23 +712049,23 @@ }, { "sim":51.0, - "partner":"8vip" + "partner":"8vit" }, { "sim":51.0, - "partner":"8viq" + "partner":"2xx3" }, { "sim":51.0, - "partner":"8vir" + "partner":"8vip" }, { "sim":51.0, - "partner":"8vit" + "partner":"8viq" }, { "sim":51.0, - "partner":"2xx3" + "partner":"8vir" }, { "sim":51.0, @@ -709158,7 +712089,7 @@ }, { "sim":51.0, - "partner":"7o2t" + "partner":"6z17" }, { "sim":51.0, @@ -709166,11 +712097,11 @@ }, { "sim":51.0, - "partner":"6z17" + "partner":"6yz3" }, { "sim":51.0, - "partner":"6yz3" + "partner":"6tpr" }, { "sim":51.0, @@ -709178,15 +712109,15 @@ }, { "sim":51.0, - "partner":"6tpr" + "partner":"6z07" }, { "sim":51.0, - "partner":"6z07" + "partner":"6z5k" }, { "sim":51.0, - "partner":"6z5k" + "partner":"7o2t" }, { "sim":51.0, @@ -709232,10 +712163,6 @@ "sim":51.0, "partner":"1e42" }, - { - "sim":51.0, - "partner":"5h5a" - }, { "sim":51.0, "partner":"3v3d" @@ -709248,6 +712175,10 @@ "sim":51.0, "partner":"5owf" }, + { + "sim":51.0, + "partner":"5h5a" + }, { "sim":51.0, "partner":"2cm1" @@ -709274,11 +712205,11 @@ }, { "sim":51.0, - "partner":"5du6" + "partner":"2ouk" }, { "sim":51.0, - "partner":"2ouk" + "partner":"5du6" }, { "sim":51.0, @@ -709334,23 +712265,23 @@ }, { "sim":51.0, - "partner":"6ub4" + "partner":"6ub2" }, { "sim":51.0, - "partner":"6ub5" + "partner":"6ub3" }, { "sim":51.0, - "partner":"6ub6" + "partner":"6ub4" }, { "sim":51.0, - "partner":"6ub2" + "partner":"6ub5" }, { "sim":51.0, - "partner":"6ub3" + "partner":"6ub6" }, { "sim":51.0, @@ -709370,24 +712301,12 @@ }, { "sim":51.0, - "partner":"5coq" - }, - { - "sim":51.0, - "partner":"5cpb" - }, - { - "sim":51.0, - "partner":"5mtr" + "partner":"4oxk" }, { "sim":51.0, "partner":"5ugt" }, - { - "sim":51.0, - "partner":"4oxk" - }, { "sim":51.0, "partner":"5ugu" @@ -709398,15 +712317,15 @@ }, { "sim":51.0, - "partner":"4oxn" + "partner":"6yuu" }, { "sim":51.0, - "partner":"4oyr" + "partner":"4oxn" }, { "sim":51.0, - "partner":"6yuu" + "partner":"4oyr" }, { "sim":51.0, @@ -709432,10 +712351,22 @@ "sim":51.0, "partner":"5cp8" }, + { + "sim":51.0, + "partner":"5mtr" + }, { "sim":51.0, "partner":"5ugs" }, + { + "sim":51.0, + "partner":"5cpb" + }, + { + "sim":51.0, + "partner":"5coq" + }, { "sim":51.0, "partner":"5zz3" @@ -709466,11 +712397,11 @@ }, { "sim":51.0, - "partner":"1xhl" + "partner":"6p7g" }, { "sim":51.0, - "partner":"6p7g" + "partner":"1xhl" }, { "sim":51.0, @@ -709484,10 +712415,6 @@ "sim":51.0, "partner":"8tms" }, - { - "sim":51.0, - "partner":"3s3h" - }, { "sim":51.0, "partner":"3s3k" @@ -709502,7 +712429,7 @@ }, { "sim":51.0, - "partner":"7xif" + "partner":"3s3h" }, { "sim":51.0, @@ -709518,7 +712445,7 @@ }, { "sim":51.0, - "partner":"3g3d" + "partner":"7xif" }, { "sim":51.0, @@ -709536,6 +712463,10 @@ "sim":51.0, "partner":"4hkp" }, + { + "sim":51.0, + "partner":"3g3d" + }, { "sim":51.0, "partner":"7e4m" @@ -709688,14 +712619,6 @@ "sim":51.0, "partner":"4xzz" }, - { - "sim":51.0, - "partner":"5gg5" - }, - { - "sim":51.0, - "partner":"5xd1" - }, { "sim":51.0, "partner":"5gg6" @@ -709708,6 +712631,10 @@ "sim":51.0, "partner":"5xd3" }, + { + "sim":51.0, + "partner":"6m6y" + }, { "sim":51.0, "partner":"5gg7" @@ -709718,11 +712645,11 @@ }, { "sim":51.0, - "partner":"5xd5" + "partner":"6m65" }, { "sim":51.0, - "partner":"6m6y" + "partner":"5xd5" }, { "sim":51.0, @@ -709732,10 +712659,6 @@ "sim":51.0, "partner":"5hos" }, - { - "sim":51.0, - "partner":"6m65" - }, { "sim":51.0, "partner":"5gg9" @@ -709766,19 +712689,23 @@ }, { "sim":51.0, - "partner":"7r2e" + "partner":"5gg5" }, { "sim":51.0, - "partner":"3ren" + "partner":"5xd1" }, { "sim":51.0, - "partner":"5v8y" + "partner":"7r2e" }, { "sim":51.0, - "partner":"5jyf" + "partner":"3ren" + }, + { + "sim":51.0, + "partner":"5v8y" }, { "sim":51.0, @@ -709818,7 +712745,7 @@ }, { "sim":51.0, - "partner":"1vsu" + "partner":"5jyf" }, { "sim":51.0, @@ -709832,6 +712759,10 @@ "sim":51.0, "partner":"5eqn" }, + { + "sim":51.0, + "partner":"1vsu" + }, { "sim":51.0, "partner":"6nor" @@ -709892,10 +712823,6 @@ "sim":51.0, "partner":"4rct" }, - { - "sim":51.0, - "partner":"4m1i" - }, { "sim":51.0, "partner":"4aub" @@ -709914,12 +712841,16 @@ }, { "sim":51.0, - "partner":"6eow" + "partner":"4m1i" }, { "sim":51.0, "partner":"4lxl" }, + { + "sim":51.0, + "partner":"6eow" + }, { "sim":51.0, "partner":"3wnb" @@ -709972,14 +712903,6 @@ "sim":51.0, "partner":"4ot7" }, - { - "sim":51.0, - "partner":"3pz9" - }, - { - "sim":51.0, - "partner":"6put" - }, { "sim":51.0, "partner":"6puw" @@ -709994,11 +712917,11 @@ }, { "sim":51.0, - "partner":"3dt1" + "partner":"6puy" }, { "sim":51.0, - "partner":"6puy" + "partner":"3dt1" }, { "sim":51.0, @@ -710008,6 +712931,10 @@ "sim":51.0, "partner":"3pzm" }, + { + "sim":51.0, + "partner":"6puz" + }, { "sim":51.0, "partner":"3pzn" @@ -710022,7 +712949,7 @@ }, { "sim":51.0, - "partner":"6puz" + "partner":"6put" }, { "sim":51.0, @@ -710030,7 +712957,7 @@ }, { "sim":51.0, - "partner":"6ojx" + "partner":"3pz9" }, { "sim":51.0, @@ -710062,16 +712989,20 @@ }, { "sim":51.0, - "partner":"7dmb" + "partner":"6ojx" }, { "sim":51.0, - "partner":"8bao" + "partner":"7dmb" }, { "sim":51.0, "partner":"5j8x" }, + { + "sim":51.0, + "partner":"8bao" + }, { "sim":51.0, "partner":"5tzb" @@ -710172,10 +713103,6 @@ "sim":51.0, "partner":"6n85" }, - { - "sim":51.0, - "partner":"4lre" - }, { "sim":51.0, "partner":"4lrf" @@ -710208,6 +713135,10 @@ "sim":51.0, "partner":"4lrd" }, + { + "sim":51.0, + "partner":"4lre" + }, { "sim":51.0, "partner":"2w7y" @@ -710258,27 +713189,27 @@ }, { "sim":51.0, - "partner":"6ry0" + "partner":"6ry5" }, { "sim":51.0, - "partner":"6ry1" + "partner":"6ry6" }, { "sim":51.0, - "partner":"6ry2" + "partner":"6ry7" }, { "sim":51.0, - "partner":"6ry5" + "partner":"6ry0" }, { "sim":51.0, - "partner":"6ry6" + "partner":"6ry1" }, { "sim":51.0, - "partner":"6ry7" + "partner":"6ry2" }, { "sim":51.0, @@ -710294,11 +713225,11 @@ }, { "sim":51.0, - "partner":"8il0" + "partner":"8ila" }, { "sim":51.0, - "partner":"8ila" + "partner":"8il0" }, { "sim":51.0, @@ -710306,15 +713237,15 @@ }, { "sim":51.0, - "partner":"5v1s" + "partner":"5v1t" }, { "sim":51.0, - "partner":"5v1t" + "partner":"8s9i" }, { "sim":51.0, - "partner":"8s9i" + "partner":"8gme" }, { "sim":51.0, @@ -710322,11 +713253,11 @@ }, { "sim":51.0, - "partner":"8gme" + "partner":"5v1q" }, { "sim":51.0, - "partner":"5v1q" + "partner":"5v1s" }, { "sim":51.0, @@ -710406,15 +713337,15 @@ }, { "sim":51.0, - "partner":"4l2h" + "partner":"4epp" }, { "sim":51.0, - "partner":"4epp" + "partner":"4epq" }, { "sim":51.0, - "partner":"4epq" + "partner":"4l2h" }, { "sim":51.0, @@ -710436,10 +713367,6 @@ "sim":51.0, "partner":"4cp8" }, - { - "sim":51.0, - "partner":"6rk2" - }, { "sim":51.0, "partner":"6rjo" @@ -710454,19 +713381,19 @@ }, { "sim":51.0, - "partner":"6jmw" + "partner":"6rk2" }, { "sim":51.0, - "partner":"6jzs" + "partner":"6jmw" }, { "sim":51.0, - "partner":"5l77" + "partner":"6jzs" }, { "sim":51.0, - "partner":"6pt4" + "partner":"5l77" }, { "sim":51.0, @@ -710480,6 +713407,10 @@ "sim":51.0, "partner":"6ptk" }, + { + "sim":51.0, + "partner":"6pt4" + }, { "sim":51.0, "partner":"6rim" @@ -710634,27 +713565,27 @@ }, { "sim":51.0, - "partner":"4ids" + "partner":"4lem" }, { "sim":51.0, - "partner":"4jdc" + "partner":"4idm" }, { "sim":51.0, - "partner":"4lem" + "partner":"4ns3" }, { "sim":51.0, - "partner":"4idm" + "partner":"4ihi" }, { "sim":51.0, - "partner":"4ns3" + "partner":"4ids" }, { "sim":51.0, - "partner":"4ihi" + "partner":"4jdc" }, { "sim":51.0, @@ -710682,15 +713613,15 @@ }, { "sim":51.0, - "partner":"5tsh" + "partner":"6olj" }, { "sim":51.0, - "partner":"6olj" + "partner":"5tsg" }, { "sim":51.0, - "partner":"5tsg" + "partner":"5tsh" }, { "sim":51.0, @@ -710706,11 +713637,11 @@ }, { "sim":51.0, - "partner":"7jwf" + "partner":"7jw4" }, { "sim":51.0, - "partner":"7jw4" + "partner":"7jwf" }, { "sim":51.0, @@ -710730,15 +713661,15 @@ }, { "sim":51.0, - "partner":"6k8s" + "partner":"6k8t" }, { "sim":51.0, - "partner":"6k8t" + "partner":"6k8u" }, { "sim":51.0, - "partner":"6k8u" + "partner":"6k8s" }, { "sim":51.0, @@ -710756,10 +713687,6 @@ "sim":51.0, "partner":"5x7h" }, - { - "sim":51.0, - "partner":"7wlg" - }, { "sim":51.0, "partner":"7wj9" @@ -710790,23 +713717,19 @@ }, { "sim":51.0, - "partner":"7p1g" - }, - { - "sim":51.0, - "partner":"3slk" + "partner":"7wlg" }, { "sim":51.0, - "partner":"7p1h" + "partner":"7p1g" }, { "sim":51.0, - "partner":"4j3t" + "partner":"3slk" }, { "sim":51.0, - "partner":"4j3u" + "partner":"7p1h" }, { "sim":51.0, @@ -710826,7 +713749,11 @@ }, { "sim":51.0, - "partner":"5y1h" + "partner":"4j3t" + }, + { + "sim":51.0, + "partner":"4j3u" }, { "sim":51.0, @@ -710872,6 +713799,10 @@ "sim":51.0, "partner":"5y3i" }, + { + "sim":51.0, + "partner":"5y1h" + }, { "sim":51.0, "partner":"7s6b" @@ -710896,10 +713827,6 @@ "sim":51.0, "partner":"3va7" }, - { - "sim":51.0, - "partner":"6yt0" - }, { "sim":51.0, "partner":"4zhj" @@ -710916,6 +713843,10 @@ "sim":51.0, "partner":"6ytj" }, + { + "sim":51.0, + "partner":"6yt0" + }, { "sim":50.0, "partner":"4omp" @@ -711050,11 +713981,11 @@ }, { "sim":50.0, - "partner":"6tq2" + "partner":"6tq1" }, { "sim":50.0, - "partner":"6tq1" + "partner":"6tq2" }, { "sim":50.0, @@ -711102,11 +714033,11 @@ }, { "sim":50.0, - "partner":"2wja" + "partner":"7a6p" }, { "sim":50.0, - "partner":"7a6p" + "partner":"2wja" }, { "sim":50.0, @@ -711114,15 +714045,15 @@ }, { "sim":50.0, - "partner":"7r5n" + "partner":"4ip3" }, { "sim":50.0, - "partner":"4ip3" + "partner":"7r5n" }, { "sim":50.0, - "partner":"5edd" + "partner":"8p8o" }, { "sim":50.0, @@ -711150,15 +714081,15 @@ }, { "sim":50.0, - "partner":"8p8o" + "partner":"1sm8" }, { "sim":50.0, - "partner":"1sm8" + "partner":"3hza" }, { "sim":50.0, - "partner":"3hza" + "partner":"5edd" }, { "sim":50.0, @@ -711218,15 +714149,15 @@ }, { "sim":50.0, - "partner":"4gzc" + "partner":"4gzd" }, { "sim":50.0, - "partner":"4gzd" + "partner":"7eh9" }, { "sim":50.0, - "partner":"7eh9" + "partner":"4gzc" }, { "sim":50.0, @@ -711320,10 +714251,6 @@ "sim":50.0, "partner":"2gcp" }, - { - "sim":50.0, - "partner":"3th5" - }, { "sim":50.0, "partner":"4gzl" @@ -711342,7 +714269,7 @@ }, { "sim":50.0, - "partner":"3l1u" + "partner":"3th5" }, { "sim":50.0, @@ -711360,6 +714287,10 @@ "sim":50.0, "partner":"3esr" }, + { + "sim":50.0, + "partner":"3l1u" + }, { "sim":50.0, "partner":"2l22" @@ -711390,15 +714321,15 @@ }, { "sim":50.0, - "partner":"6a98" + "partner":"6a99" }, { "sim":50.0, - "partner":"6a99" + "partner":"6a9f" }, { "sim":50.0, - "partner":"6a9f" + "partner":"6a98" }, { "sim":50.0, @@ -711422,31 +714353,31 @@ }, { "sim":50.0, - "partner":"7mnq" + "partner":"7mns" }, { "sim":50.0, - "partner":"7mnr" + "partner":"7mnt" }, { "sim":50.0, - "partner":"7mns" + "partner":"4irb" }, { "sim":50.0, - "partner":"4irb" + "partner":"7mnu" }, { "sim":50.0, - "partner":"7mnt" + "partner":"7mnv" }, { "sim":50.0, - "partner":"7mnu" + "partner":"7mnq" }, { "sim":50.0, - "partner":"7mnv" + "partner":"7mnr" }, { "sim":50.0, @@ -711496,10 +714427,6 @@ "sim":50.0, "partner":"4zb1" }, - { - "sim":50.0, - "partner":"4da6" - }, { "sim":50.0, "partner":"4da7" @@ -711554,15 +714481,19 @@ }, { "sim":50.0, - "partner":"2dps" + "partner":"4da6" }, { "sim":50.0, - "partner":"2dpt" + "partner":"8bat" }, { "sim":50.0, - "partner":"8bat" + "partner":"2dps" + }, + { + "sim":50.0, + "partner":"2dpt" }, { "sim":50.0, @@ -711632,10 +714563,6 @@ "sim":50.0, "partner":"5m09" }, - { - "sim":50.0, - "partner":"3dbp" - }, { "sim":50.0, "partner":"3mo7" @@ -711658,23 +714585,27 @@ }, { "sim":50.0, - "partner":"6t2p" + "partner":"3dbp" }, { "sim":50.0, - "partner":"2wk1" + "partner":"6akv" }, { "sim":50.0, - "partner":"6t2q" + "partner":"6t2o" }, { "sim":50.0, - "partner":"6akv" + "partner":"6t2p" }, { "sim":50.0, - "partner":"6t2o" + "partner":"6t2q" + }, + { + "sim":50.0, + "partner":"2wk1" }, { "sim":50.0, @@ -711742,19 +714673,19 @@ }, { "sim":50.0, - "partner":"5lsg" + "partner":"6t9c" }, { "sim":50.0, - "partner":"6t9c" + "partner":"5lsg" }, { "sim":50.0, - "partner":"5l45" + "partner":"6qj5" }, { "sim":50.0, - "partner":"6qj5" + "partner":"5l45" }, { "sim":50.0, @@ -711770,11 +714701,11 @@ }, { "sim":50.0, - "partner":"6y5x" + "partner":"6y5y" }, { "sim":50.0, - "partner":"6y5y" + "partner":"6y5x" }, { "sim":50.0, @@ -711796,10 +714727,6 @@ "sim":50.0, "partner":"2qj3" }, - { - "sim":50.0, - "partner":"3aio" - }, { "sim":50.0, "partner":"3aik" @@ -711820,6 +714747,10 @@ "sim":50.0, "partner":"3ain" }, + { + "sim":50.0, + "partner":"3aio" + }, { "sim":50.0, "partner":"6t2n" @@ -711830,19 +714761,19 @@ }, { "sim":50.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":50.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":50.0, - "partner":"3tm8" + "partner":"3tmc" }, { "sim":50.0, - "partner":"3tmb" + "partner":"3tmd" }, { "sim":50.0, @@ -711852,10 +714783,6 @@ "sim":50.0, "partner":"3rlh" }, - { - "sim":50.0, - "partner":"2pzm" - }, { "sim":50.0, "partner":"2qry" @@ -711870,12 +714797,16 @@ }, { "sim":50.0, - "partner":"6lcn" + "partner":"2pzm" }, { "sim":50.0, "partner":"7x1l" }, + { + "sim":50.0, + "partner":"6lcn" + }, { "sim":50.0, "partner":"7f8d" @@ -711988,18 +714919,6 @@ "sim":50.0, "partner":"4ilk" }, - { - "sim":50.0, - "partner":"4m25" - }, - { - "sim":50.0, - "partner":"4m2i" - }, - { - "sim":50.0, - "partner":"4ne0" - }, { "sim":50.0, "partner":"4m26" @@ -712036,6 +714955,18 @@ "sim":50.0, "partner":"4m2g" }, + { + "sim":50.0, + "partner":"4m25" + }, + { + "sim":50.0, + "partner":"4m2i" + }, + { + "sim":50.0, + "partner":"4ne0" + }, { "sim":50.0, "partner":"7us5" @@ -712086,23 +715017,23 @@ }, { "sim":50.0, - "partner":"2a9y" + "partner":"2aa0" }, { "sim":50.0, - "partner":"2a9z" + "partner":"2abs" }, { "sim":50.0, - "partner":"2aa0" + "partner":"2ab8" }, { "sim":50.0, - "partner":"2abs" + "partner":"2a9y" }, { "sim":50.0, - "partner":"2ab8" + "partner":"2a9z" }, { "sim":50.0, @@ -712130,31 +715061,31 @@ }, { "sim":50.0, - "partner":"6zgp" + "partner":"6y9d" }, { "sim":50.0, - "partner":"6y8j" + "partner":"6zgp" }, { "sim":50.0, - "partner":"6y9c" + "partner":"2qap" }, { "sim":50.0, - "partner":"6y9d" + "partner":"6y8s" }, { "sim":50.0, - "partner":"2qap" + "partner":"2qdg" }, { "sim":50.0, - "partner":"6y8s" + "partner":"6y8j" }, { "sim":50.0, - "partner":"2qdg" + "partner":"6y9c" }, { "sim":50.0, @@ -712230,11 +715161,7 @@ }, { "sim":50.0, - "partner":"5dvi" - }, - { - "sim":50.0, - "partner":"5xw2" + "partner":"4e2p" }, { "sim":50.0, @@ -712242,11 +715169,11 @@ }, { "sim":50.0, - "partner":"4e2p" + "partner":"3ssm" }, { "sim":50.0, - "partner":"3ssm" + "partner":"8d19" }, { "sim":50.0, @@ -712254,16 +715181,12 @@ }, { "sim":50.0, - "partner":"8d19" + "partner":"8czk" }, { "sim":50.0, "partner":"3sso" }, - { - "sim":50.0, - "partner":"8czk" - }, { "sim":50.0, "partner":"8czl" @@ -712276,6 +715199,14 @@ "sim":50.0, "partner":"5dvf" }, + { + "sim":50.0, + "partner":"5dvi" + }, + { + "sim":50.0, + "partner":"5xw2" + }, { "sim":50.0, "partner":"3zu2" @@ -712314,15 +715245,15 @@ }, { "sim":50.0, - "partner":"5z8a" + "partner":"5z8k" }, { "sim":50.0, - "partner":"5z8k" + "partner":"5z83" }, { "sim":50.0, - "partner":"5z83" + "partner":"5z8a" }, { "sim":50.0, @@ -712428,10 +715359,6 @@ "sim":50.0, "partner":"6qps" }, - { - "sim":50.0, - "partner":"2wc4" - }, { "sim":50.0, "partner":"1oif" @@ -712544,6 +715471,10 @@ "sim":50.0, "partner":"1uz1" }, + { + "sim":50.0, + "partner":"2wc4" + }, { "sim":50.0, "partner":"6j0u" @@ -712632,10 +715563,6 @@ "sim":50.0, "partner":"4ife" }, - { - "sim":50.0, - "partner":"5uno" - }, { "sim":50.0, "partner":"7m7c" @@ -712654,11 +715581,11 @@ }, { "sim":50.0, - "partner":"4l6w" + "partner":"5uno" }, { "sim":50.0, - "partner":"6x0h" + "partner":"4l6w" }, { "sim":50.0, @@ -712668,6 +715595,10 @@ "sim":50.0, "partner":"6x0k" }, + { + "sim":50.0, + "partner":"6x0h" + }, { "sim":50.0, "partner":"6pop" @@ -712690,11 +715621,11 @@ }, { "sim":50.0, - "partner":"7an1" + "partner":"7oqd" }, { "sim":50.0, - "partner":"7oqd" + "partner":"7an1" }, { "sim":50.0, @@ -712746,15 +715677,15 @@ }, { "sim":50.0, - "partner":"7mdl" + "partner":"8g9z" }, { "sim":50.0, - "partner":"8g9z" + "partner":"7l1t" }, { "sim":50.0, - "partner":"7l1t" + "partner":"7mdl" }, { "sim":50.0, @@ -712778,47 +715709,47 @@ }, { "sim":50.0, - "partner":"8aq3" + "partner":"7aci" }, { "sim":50.0, - "partner":"8aq4" + "partner":"8b0k" }, { "sim":50.0, - "partner":"7aci" + "partner":"8b0l" }, { "sim":50.0, - "partner":"8b0k" + "partner":"8b0m" }, { "sim":50.0, - "partner":"5n6h" + "partner":"8b0n" }, { "sim":50.0, - "partner":"8b0l" + "partner":"5n6h" }, { "sim":50.0, - "partner":"8b0m" + "partner":"8b0o" }, { "sim":50.0, - "partner":"8b0n" + "partner":"8b0p" }, { "sim":50.0, - "partner":"8b0o" + "partner":"5n6l" }, { "sim":50.0, - "partner":"8b0p" + "partner":"8aq3" }, { "sim":50.0, - "partner":"5n6l" + "partner":"8aq4" }, { "sim":50.0, @@ -712950,15 +715881,15 @@ }, { "sim":50.0, - "partner":"7w1c" + "partner":"7w1d" }, { "sim":50.0, - "partner":"7w1d" + "partner":"7w1e" }, { "sim":50.0, - "partner":"7w1e" + "partner":"7w1c" }, { "sim":50.0, @@ -713026,15 +715957,15 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"6edz" }, { "sim":50.0, - "partner":"6edz" + "partner":"6ee1" }, { "sim":50.0, - "partner":"6ee1" + "partner":"6edw" }, { "sim":50.0, @@ -713076,7 +716007,7 @@ ], "seq_max_sim_designed":{ "sim":428.0, - "partner":"8j1x" + "partner":"8j98" }, "seq_max_sim_natural":{ "sim":233.0, @@ -713170,90 +716101,90 @@ ], "subtitle":"A near-infrared fluorescent protein of de novo backbone design", "tags":[ - "de novo backbone design", "monomerization", "de novo protein", - "near-infrared fluorescent protein" + "near-infrared fluorescent protein", + "de novo backbone design" ], "keywords":[ - "evolution", - "monomeric", - "use", - "imaging", + "molecular", + "shield", + "nir", + "13", + "fluorescent", + "new", "strategy", - "place", - "designed", + "protein", + "binding", + "weight", + "confirmed", + "apo", + "forms", + "systems", "potentially", - "experimentally", - "crystal", - "dmsmurfp", - "determined", - "based", - "enhanced", - "structure", - "applied", - "monomerize", - "fluorescence", - "biliverdin", "original", - "chain", - "proteins", - "employed", - "characterized", - "covering", - "kda", - "small", - "interface", - "used", "intersubunit", + "two", + "crystal", + "weak", + "stable", "binds", - "smurfp", - "structures", - "naturally", - "mammalian", - "suitable", - "second", - "multimeric", - "systems", + "helices", + "complex", + "characterized", + "dimer", + "experimentally", + "monomerize", + "place", + "covering", + "proteins", + "sites", "rounds", - "fluorescent", + "use", + "segment", + "biliverdin", + "interface", + "small", + "evolution", "obtained", - "molecular", - "demonstrated", - "functional", - "bright", - "engineer", - "dimer", - "fp", - "apo", + "pocket", + "mammalian", "design", - "weight", - "weak", - "nir", - "segment", - "13", - "sites", - "designs", - "helices", + "enhanced", + "chain", + "used", + "functional", + "dmsmurfp", "also", - "stable", - "directed", - "confirmed", - "two", - "state", - "protein", - "shield", - "complex", + "kda", "backbone", - "bioimaging", - "extend", + "applied", + "demonstrated", "chromophore", - "ultrared", + "engineer", + "fluorescence", + "designed", + "employed", + "directed", + "naturally", "vivo", - "pocket", - "binding", - "forms", - "new" + "structures", + "fp", + "suitable", + "smurfp", + "imaging", + "based", + "structure", + "monomeric", + "determined", + "bioimaging", + "multimeric", + "state", + "bright", + "ultrared", + "extend", + "second", + "designs" ], "release_date":"2023-10-04", "publication":"\"Using Protein Design and Directed Evolution to Monomerize a Bright Near-Infrared Fluorescent Protein\", Acs Synth Biol, 13, 1177-1190", @@ -713302,11 +716233,11 @@ }, { "sim":77.0, - "partner":"8jpa" + "partner":"8hdv" }, { "sim":77.0, - "partner":"8hdv" + "partner":"8jpa" }, { "sim":74.0, @@ -713326,7 +716257,7 @@ }, { "sim":51.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":51.0, @@ -713334,15 +716265,15 @@ }, { "sim":51.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":51.0, - "partner":"8w08" + "partner":"8w06" }, { "sim":51.0, - "partner":"8w05" + "partner":"8v0a" }, { "sim":51.0, @@ -713350,11 +716281,11 @@ }, { "sim":50.0, - "partner":"8v2w" + "partner":"8v09" }, { "sim":50.0, - "partner":"8v09" + "partner":"8v2w" } ], "seq_thr_sim_natural":[ @@ -713380,15 +716311,15 @@ }, { "sim":140.0, - "partner":"7sc9" + "partner":"7sc7" }, { "sim":140.0, - "partner":"7sc7" + "partner":"7scb" }, { "sim":140.0, - "partner":"7scb" + "partner":"7sc9" }, { "sim":138.0, @@ -713396,23 +716327,23 @@ }, { "sim":136.0, - "partner":"6kgx" + "partner":"7ezx" }, { "sim":136.0, - "partner":"7y7a" + "partner":"7y4l" }, { "sim":136.0, - "partner":"7ezx" + "partner":"7y5e" }, { "sim":136.0, - "partner":"7y4l" + "partner":"6kgx" }, { "sim":136.0, - "partner":"7y5e" + "partner":"7y7a" }, { "sim":132.0, @@ -713516,11 +716447,11 @@ }, { "sim":76.0, - "partner":"7y0k" + "partner":"7xwu" }, { "sim":76.0, - "partner":"7xwu" + "partner":"7y0k" }, { "sim":75.0, @@ -713546,10 +716477,6 @@ "sim":75.0, "partner":"3roj" }, - { - "sim":75.0, - "partner":"3nc3" - }, { "sim":75.0, "partner":"3nc5" @@ -713562,6 +716489,10 @@ "sim":75.0, "partner":"3nc7" }, + { + "sim":75.0, + "partner":"3nc3" + }, { "sim":75.0, "partner":"4h5y" @@ -713586,18 +716517,6 @@ "sim":74.0, "partner":"3s2s" }, - { - "sim":74.0, - "partner":"7ex2" - }, - { - "sim":74.0, - "partner":"7ex3" - }, - { - "sim":74.0, - "partner":"7ex4" - }, { "sim":74.0, "partner":"7ex6" @@ -713646,6 +716565,18 @@ "sim":74.0, "partner":"7ex1" }, + { + "sim":74.0, + "partner":"7ex2" + }, + { + "sim":74.0, + "partner":"7ex3" + }, + { + "sim":74.0, + "partner":"7ex4" + }, { "sim":74.0, "partner":"5u4z" @@ -713774,10 +716705,6 @@ "sim":73.0, "partner":"6wyn" }, - { - "sim":73.0, - "partner":"7dw8" - }, { "sim":73.0, "partner":"7dwa" @@ -713796,15 +716723,15 @@ }, { "sim":73.0, - "partner":"4y0x" + "partner":"7dw8" }, { "sim":73.0, - "partner":"4y12" + "partner":"4y0x" }, { "sim":73.0, - "partner":"6jtl" + "partner":"4y12" }, { "sim":73.0, @@ -713820,19 +716747,19 @@ }, { "sim":73.0, - "partner":"4lit" + "partner":"6jtl" }, { "sim":73.0, - "partner":"4liu" + "partner":"4lit" }, { "sim":73.0, - "partner":"4liv" + "partner":"4liu" }, { "sim":73.0, - "partner":"3pln" + "partner":"4liv" }, { "sim":73.0, @@ -713846,6 +716773,10 @@ "sim":73.0, "partner":"3pjg" }, + { + "sim":73.0, + "partner":"3pln" + }, { "sim":73.0, "partner":"5gvx" @@ -713876,28 +716807,20 @@ }, { "sim":73.0, - "partner":"6unz" - }, - { - "sim":73.0, - "partner":"6uoj" + "partner":"6msn" }, { "sim":73.0, - "partner":"6upo" + "partner":"6unz" }, { "sim":73.0, - "partner":"6msn" + "partner":"6uq8" }, { "sim":73.0, "partner":"5l2r" }, - { - "sim":73.0, - "partner":"6uq8" - }, { "sim":73.0, "partner":"6uo0" @@ -713934,17 +716857,25 @@ "sim":73.0, "partner":"6up9" }, + { + "sim":73.0, + "partner":"6uoj" + }, + { + "sim":73.0, + "partner":"6upo" + }, { "sim":72.0, "partner":"6hrk" }, { "sim":72.0, - "partner":"6isk" + "partner":"6isl" }, { "sim":72.0, - "partner":"6isl" + "partner":"6isk" }, { "sim":72.0, @@ -714030,10 +716961,6 @@ "sim":72.0, "partner":"3wg8" }, - { - "sim":72.0, - "partner":"2uxx" - }, { "sim":72.0, "partner":"2iw5" @@ -714046,6 +716973,10 @@ "sim":72.0, "partner":"4kum" }, + { + "sim":72.0, + "partner":"2uxx" + }, { "sim":72.0, "partner":"7vxo" @@ -714126,10 +717057,6 @@ "sim":72.0, "partner":"6ddn" }, - { - "sim":72.0, - "partner":"3tro" - }, { "sim":72.0, "partner":"3tjx" @@ -714142,6 +717069,10 @@ "sim":72.0, "partner":"7myd" }, + { + "sim":72.0, + "partner":"3tro" + }, { "sim":72.0, "partner":"7m4s" @@ -714168,27 +717099,27 @@ }, { "sim":72.0, - "partner":"6alm" + "partner":"6alo" }, { "sim":72.0, - "partner":"6aln" + "partner":"6alp" }, { "sim":72.0, - "partner":"6alo" + "partner":"6alq" }, { "sim":72.0, - "partner":"6alp" + "partner":"6alr" }, { "sim":72.0, - "partner":"6alq" + "partner":"6alm" }, { "sim":72.0, - "partner":"6alr" + "partner":"6aln" }, { "sim":72.0, @@ -714256,11 +717187,11 @@ }, { "sim":72.0, - "partner":"4nxl" + "partner":"4jek" }, { "sim":72.0, - "partner":"4jek" + "partner":"4nxl" }, { "sim":72.0, @@ -714294,6 +717225,18 @@ "sim":72.0, "partner":"6lkc" }, + { + "sim":72.0, + "partner":"8vjq" + }, + { + "sim":72.0, + "partner":"8vix" + }, + { + "sim":72.0, + "partner":"8vh0" + }, { "sim":72.0, "partner":"6jym" @@ -714364,11 +717307,11 @@ }, { "sim":71.0, - "partner":"6mwy" + "partner":"6myl" }, { "sim":71.0, - "partner":"6myl" + "partner":"6mwy" }, { "sim":71.0, @@ -714396,11 +717339,11 @@ }, { "sim":71.0, - "partner":"3la8" + "partner":"3lba" }, { "sim":71.0, - "partner":"3lba" + "partner":"3la8" }, { "sim":71.0, @@ -714480,23 +717423,23 @@ }, { "sim":71.0, - "partner":"7ffg" + "partner":"7ffi" }, { "sim":71.0, - "partner":"7ffh" + "partner":"7ffa" }, { "sim":71.0, - "partner":"7ffi" + "partner":"7ffc" }, { "sim":71.0, - "partner":"7ffa" + "partner":"7ffg" }, { "sim":71.0, - "partner":"7ffc" + "partner":"7ffh" }, { "sim":71.0, @@ -714548,11 +717491,11 @@ }, { "sim":71.0, - "partner":"3l7r" + "partner":"3t0c" }, { "sim":71.0, - "partner":"3t0c" + "partner":"3l7r" }, { "sim":70.0, @@ -714586,10 +717529,6 @@ "sim":70.0, "partner":"3l1n" }, - { - "sim":70.0, - "partner":"4m02" - }, { "sim":70.0, "partner":"3zez" @@ -714626,6 +717565,10 @@ "sim":70.0, "partner":"5ffa" }, + { + "sim":70.0, + "partner":"4m02" + }, { "sim":70.0, "partner":"4e2a" @@ -714640,11 +717583,11 @@ }, { "sim":70.0, - "partner":"5nbt" + "partner":"6gzc" }, { "sim":70.0, - "partner":"6gzc" + "partner":"5nbt" }, { "sim":70.0, @@ -714670,10 +717613,6 @@ "sim":70.0, "partner":"4nod" }, - { - "sim":70.0, - "partner":"5nbh" - }, { "sim":70.0, "partner":"5n8d" @@ -714686,6 +717625,10 @@ "sim":70.0, "partner":"5n83" }, + { + "sim":70.0, + "partner":"5nbh" + }, { "sim":70.0, "partner":"3l87" @@ -714734,10 +717677,6 @@ "sim":70.0, "partner":"5ywt" }, - { - "sim":70.0, - "partner":"7eny" - }, { "sim":70.0, "partner":"8hp5" @@ -714752,19 +717691,23 @@ }, { "sim":70.0, - "partner":"5feu" + "partner":"7eny" }, { "sim":70.0, - "partner":"6pei" + "partner":"6pej" }, { "sim":70.0, - "partner":"6pej" + "partner":"6y4d" }, { "sim":70.0, - "partner":"6y4d" + "partner":"6pei" + }, + { + "sim":70.0, + "partner":"5feu" }, { "sim":70.0, @@ -714798,10 +717741,6 @@ "sim":70.0, "partner":"3b3d" }, - { - "sim":70.0, - "partner":"5yoi" - }, { "sim":70.0, "partner":"5ypj" @@ -714818,6 +717757,10 @@ "sim":70.0, "partner":"5yoh" }, + { + "sim":70.0, + "partner":"5yoi" + }, { "sim":70.0, "partner":"3p2m" @@ -714864,15 +717807,11 @@ }, { "sim":70.0, - "partner":"7cm8" - }, - { - "sim":70.0, - "partner":"7djq" + "partner":"7c35" }, { "sim":70.0, - "partner":"7c35" + "partner":"7ewo" }, { "sim":70.0, @@ -714888,12 +717827,16 @@ }, { "sim":70.0, - "partner":"7ewo" + "partner":"7cm8" }, { "sim":70.0, "partner":"5xcp" }, + { + "sim":70.0, + "partner":"7djq" + }, { "sim":70.0, "partner":"7cd5" @@ -714960,15 +717903,15 @@ }, { "sim":70.0, - "partner":"8uen" + "partner":"8uro" }, { "sim":70.0, - "partner":"8ura" + "partner":"8uen" }, { "sim":70.0, - "partner":"8uro" + "partner":"8ura" }, { "sim":70.0, @@ -715098,10 +718041,6 @@ "sim":69.0, "partner":"4jbh" }, - { - "sim":69.0, - "partner":"7q9z" - }, { "sim":69.0, "partner":"3udz" @@ -715124,15 +718063,15 @@ }, { "sim":69.0, - "partner":"5e0o" + "partner":"7q9z" }, { "sim":69.0, - "partner":"4e85" + "partner":"5e0o" }, { - "sim":68.0, - "partner":"3ul6" + "sim":69.0, + "partner":"4e85" }, { "sim":68.0, @@ -715140,7 +718079,7 @@ }, { "sim":68.0, - "partner":"4d1f" + "partner":"3ul6" }, { "sim":68.0, @@ -715150,6 +718089,10 @@ "sim":68.0, "partner":"4d0u" }, + { + "sim":68.0, + "partner":"4d1f" + }, { "sim":68.0, "partner":"5fld" @@ -715174,10 +718117,6 @@ "sim":68.0, "partner":"5zi0" }, - { - "sim":68.0, - "partner":"2zbb" - }, { "sim":68.0, "partner":"3e4o" @@ -715190,6 +718129,10 @@ "sim":68.0, "partner":"3e4q" }, + { + "sim":68.0, + "partner":"2zbb" + }, { "sim":68.0, "partner":"4nv7" @@ -715306,26 +718249,18 @@ "sim":67.0, "partner":"4f6l" }, - { - "sim":67.0, - "partner":"4bzc" - }, { "sim":67.0, "partner":"4qg1" }, { "sim":67.0, - "partner":"6dwk" + "partner":"6dwd" }, { "sim":67.0, "partner":"4qg2" }, - { - "sim":67.0, - "partner":"6dwd" - }, { "sim":67.0, "partner":"7s2y" @@ -715374,6 +718309,14 @@ "sim":67.0, "partner":"4qg0" }, + { + "sim":67.0, + "partner":"6dwk" + }, + { + "sim":67.0, + "partner":"4bzc" + }, { "sim":67.0, "partner":"8hhe" @@ -715396,15 +718339,15 @@ }, { "sim":65.0, - "partner":"2c7j" + "partner":"2c7k" }, { "sim":65.0, - "partner":"2c7k" + "partner":"2c7l" }, { "sim":65.0, - "partner":"2c7l" + "partner":"2c7j" }, { "sim":64.0, @@ -715480,31 +718423,31 @@ }, { "sim":60.0, - "partner":"7d6w" + "partner":"7sc8" }, { "sim":60.0, - "partner":"2uul" + "partner":"7sca" }, { "sim":60.0, - "partner":"7sc8" + "partner":"1gh0" }, { "sim":60.0, - "partner":"7sca" + "partner":"7d6w" }, { "sim":60.0, - "partner":"1gh0" + "partner":"2uum" }, { "sim":60.0, - "partner":"2uum" + "partner":"4f0t" }, { "sim":60.0, - "partner":"4f0t" + "partner":"2uul" }, { "sim":60.0, @@ -715548,20 +718491,12 @@ }, { "sim":58.0, - "partner":"6ypq" + "partner":"7eh7" }, { "sim":58.0, "partner":"7veb" }, - { - "sim":58.0, - "partner":"4gy3" - }, - { - "sim":58.0, - "partner":"4n6s" - }, { "sim":58.0, "partner":"3l0f" @@ -715572,11 +718507,11 @@ }, { "sim":58.0, - "partner":"1i7y" + "partner":"6xwk" }, { "sim":58.0, - "partner":"7eh7" + "partner":"7efv" }, { "sim":58.0, @@ -715584,27 +718519,23 @@ }, { "sim":58.0, - "partner":"6xwk" + "partner":"1i7y" }, { "sim":58.0, - "partner":"1jbo" + "partner":"8fwa" }, { "sim":58.0, "partner":"4gxe" }, - { - "sim":58.0, - "partner":"7efv" - }, { "sim":58.0, "partner":"1ktp" }, { "sim":58.0, - "partner":"8fwa" + "partner":"1jbo" }, { "sim":58.0, @@ -715616,19 +718547,19 @@ }, { "sim":58.0, - "partner":"4ziz" + "partner":"7efw" }, { "sim":58.0, - "partner":"1ha7" + "partner":"4ziz" }, { "sim":58.0, - "partner":"1on7" + "partner":"7eh8" }, { "sim":58.0, - "partner":"7efw" + "partner":"1on7" }, { "sim":58.0, @@ -715636,7 +718567,7 @@ }, { "sim":58.0, - "partner":"7eh8" + "partner":"1ha7" }, { "sim":58.0, @@ -715648,11 +718579,11 @@ }, { "sim":58.0, - "partner":"3o18" + "partner":"6yyj" }, { "sim":58.0, - "partner":"6yyj" + "partner":"3o18" }, { "sim":58.0, @@ -715666,13 +718597,25 @@ "sim":58.0, "partner":"5mjq" }, + { + "sim":58.0, + "partner":"6yq8" + }, { "sim":58.0, "partner":"5o7m" }, { "sim":58.0, - "partner":"6yq8" + "partner":"6ypq" + }, + { + "sim":58.0, + "partner":"4gy3" + }, + { + "sim":58.0, + "partner":"4n6s" }, { "sim":58.0, @@ -715704,11 +718647,11 @@ }, { "sim":57.0, - "partner":"6y3d" + "partner":"6hrn" }, { "sim":57.0, - "partner":"6hrn" + "partner":"6y3d" }, { "sim":57.0, @@ -715728,11 +718671,11 @@ }, { "sim":57.0, - "partner":"4mdo" + "partner":"4mdp" }, { "sim":57.0, - "partner":"4mdp" + "partner":"4mdo" }, { "sim":57.0, @@ -715852,7 +718795,7 @@ }, { "sim":55.0, - "partner":"4lm6" + "partner":"7tlf" }, { "sim":55.0, @@ -715860,7 +718803,7 @@ }, { "sim":55.0, - "partner":"7tlf" + "partner":"4lm6" }, { "sim":55.0, @@ -715896,11 +718839,11 @@ }, { "sim":55.0, - "partner":"4jqc" + "partner":"4jx8" }, { "sim":55.0, - "partner":"4jx8" + "partner":"4jqc" }, { "sim":55.0, @@ -715922,14 +718865,6 @@ "sim":55.0, "partner":"8t0u" }, - { - "sim":55.0, - "partner":"3dyh" - }, - { - "sim":55.0, - "partner":"4rxd" - }, { "sim":55.0, "partner":"4rxe" @@ -715972,48 +718907,40 @@ }, { "sim":55.0, - "partner":"2gqn" - }, - { - "sim":55.0, - "partner":"2fq6" + "partner":"4rxd" }, { "sim":55.0, - "partner":"5jk8" + "partner":"3dyh" }, { "sim":55.0, - "partner":"5jk5" + "partner":"2fq6" }, { "sim":55.0, - "partner":"5jk6" + "partner":"2gqn" }, { "sim":55.0, - "partner":"4wya" + "partner":"5jk8" }, { "sim":55.0, - "partner":"4wyf" + "partner":"5jk5" }, { "sim":55.0, - "partner":"4cxq" + "partner":"5jk6" }, { "sim":55.0, - "partner":"5kgs" + "partner":"4cxr" }, { "sim":55.0, "partner":"4wyg" }, - { - "sim":55.0, - "partner":"4cxr" - }, { "sim":55.0, "partner":"4xjl" @@ -716078,10 +719005,26 @@ "sim":55.0, "partner":"3tfu" }, + { + "sim":55.0, + "partner":"4wya" + }, { "sim":55.0, "partner":"4wye" }, + { + "sim":55.0, + "partner":"4wyf" + }, + { + "sim":55.0, + "partner":"4cxq" + }, + { + "sim":55.0, + "partner":"5kgs" + }, { "sim":55.0, "partner":"7jrl" @@ -716112,15 +719055,15 @@ }, { "sim":54.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":54.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":54.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":54.0, @@ -716162,33 +719105,29 @@ "sim":54.0, "partner":"6e4e" }, - { - "sim":54.0, - "partner":"4f0v" - }, { "sim":54.0, "partner":"4f0w" }, { "sim":54.0, - "partner":"3q6b" + "partner":"4f0v" }, { "sim":54.0, - "partner":"4bmx" + "partner":"3q6b" }, { "sim":54.0, - "partner":"4bmy" + "partner":"4bmz" }, { "sim":54.0, - "partner":"4bmz" + "partner":"4bmx" }, { "sim":54.0, - "partner":"6o98" + "partner":"4bmy" }, { "sim":54.0, @@ -716202,6 +719141,10 @@ "sim":54.0, "partner":"6xfv" }, + { + "sim":54.0, + "partner":"6o98" + }, { "sim":54.0, "partner":"2per" @@ -716226,14 +719169,6 @@ "sim":54.0, "partner":"4x7x" }, - { - "sim":54.0, - "partner":"7kqj" - }, - { - "sim":54.0, - "partner":"6vqf" - }, { "sim":54.0, "partner":"7kxd" @@ -716278,6 +719213,14 @@ "sim":54.0, "partner":"7luk" }, + { + "sim":54.0, + "partner":"6vqf" + }, + { + "sim":54.0, + "partner":"7kqj" + }, { "sim":54.0, "partner":"3g9g" @@ -716302,10 +719245,6 @@ "sim":54.0, "partner":"3u3j" }, - { - "sim":54.0, - "partner":"3u3r" - }, { "sim":54.0, "partner":"3u3k" @@ -716318,6 +719257,10 @@ "sim":54.0, "partner":"3u3o" }, + { + "sim":54.0, + "partner":"3u3r" + }, { "sim":54.0, "partner":"4j51" @@ -716340,11 +719283,11 @@ }, { "sim":54.0, - "partner":"7js3" + "partner":"8g5w" }, { "sim":54.0, - "partner":"8g5w" + "partner":"7js3" }, { "sim":54.0, @@ -716360,11 +719303,11 @@ }, { "sim":54.0, - "partner":"6wa9" + "partner":"6wa6" }, { "sim":54.0, - "partner":"6wa6" + "partner":"6wa9" }, { "sim":54.0, @@ -716392,11 +719335,11 @@ }, { "sim":54.0, - "partner":"5dt7" + "partner":"5dt5" }, { "sim":54.0, - "partner":"5dt5" + "partner":"5dt7" }, { "sim":54.0, @@ -716512,19 +719455,19 @@ }, { "sim":53.0, - "partner":"8b9b" + "partner":"8b9a" }, { "sim":53.0, - "partner":"6skl" + "partner":"8b9c" }, { "sim":53.0, - "partner":"8b9a" + "partner":"8b9b" }, { "sim":53.0, - "partner":"8b9c" + "partner":"6skl" }, { "sim":53.0, @@ -716574,10 +719517,6 @@ "sim":53.0, "partner":"5b1y" }, - { - "sim":53.0, - "partner":"1z5z" - }, { "sim":53.0, "partner":"2f9t" @@ -716588,12 +719527,16 @@ }, { "sim":53.0, - "partner":"5tii" + "partner":"1z5z" }, { "sim":53.0, "partner":"5thq" }, + { + "sim":53.0, + "partner":"5tii" + }, { "sim":53.0, "partner":"5c2d" @@ -716614,10 +719557,6 @@ "sim":53.0, "partner":"3uic" }, - { - "sim":53.0, - "partner":"4j3f" - }, { "sim":53.0, "partner":"4j4t" @@ -716630,6 +719569,10 @@ "sim":53.0, "partner":"4j1n" }, + { + "sim":53.0, + "partner":"4j3f" + }, { "sim":53.0, "partner":"5hii" @@ -716656,19 +719599,19 @@ }, { "sim":53.0, - "partner":"7a61" + "partner":"8rwq" }, { "sim":53.0, - "partner":"5uj3" + "partner":"6mnp" }, { "sim":53.0, - "partner":"5uj4" + "partner":"8rwr" }, { "sim":53.0, - "partner":"6mnp" + "partner":"5uj3" }, { "sim":53.0, @@ -716676,7 +719619,11 @@ }, { "sim":53.0, - "partner":"5ul8" + "partner":"8rws" + }, + { + "sim":53.0, + "partner":"5uj4" }, { "sim":53.0, @@ -716690,6 +719637,10 @@ "sim":53.0, "partner":"6d17" }, + { + "sim":53.0, + "partner":"5ul8" + }, { "sim":53.0, "partner":"6d18" @@ -716744,15 +719695,15 @@ }, { "sim":53.0, - "partner":"8rwq" + "partner":"6mey" }, { "sim":53.0, - "partner":"6mey" + "partner":"6v1j" }, { "sim":53.0, - "partner":"6v1j" + "partner":"8aki" }, { "sim":53.0, @@ -716760,7 +719711,7 @@ }, { "sim":53.0, - "partner":"8aki" + "partner":"8akj" }, { "sim":53.0, @@ -716772,7 +719723,7 @@ }, { "sim":53.0, - "partner":"8akj" + "partner":"8akk" }, { "sim":53.0, @@ -716780,27 +719731,27 @@ }, { "sim":53.0, - "partner":"8akk" + "partner":"8akl" }, { "sim":53.0, - "partner":"8akl" + "partner":"8akm" }, { "sim":53.0, - "partner":"8akm" + "partner":"7a61" }, { "sim":53.0, - "partner":"6loi" + "partner":"8rwo" }, { "sim":53.0, - "partner":"3p8e" + "partner":"8rwp" }, { "sim":53.0, - "partner":"7ulx" + "partner":"6loi" }, { "sim":53.0, @@ -716834,6 +719785,14 @@ "sim":53.0, "partner":"2otn" }, + { + "sim":53.0, + "partner":"3p8e" + }, + { + "sim":53.0, + "partner":"7ulx" + }, { "sim":53.0, "partner":"3utn" @@ -716856,24 +719815,20 @@ }, { "sim":53.0, - "partner":"4w7v" + "partner":"4w7u" }, { "sim":53.0, - "partner":"4w7w" + "partner":"4w7v" }, { "sim":53.0, - "partner":"4w7u" + "partner":"4w7w" }, { "sim":53.0, "partner":"7lh6" }, - { - "sim":53.0, - "partner":"7drp" - }, { "sim":53.0, "partner":"7drm" @@ -716886,6 +719841,10 @@ "sim":53.0, "partner":"7dro" }, + { + "sim":53.0, + "partner":"7drp" + }, { "sim":53.0, "partner":"5hnn" @@ -716910,10 +719869,6 @@ "sim":53.0, "partner":"8bft" }, - { - "sim":53.0, - "partner":"7ajm" - }, { "sim":53.0, "partner":"7a4r" @@ -716928,31 +719883,15 @@ }, { "sim":53.0, - "partner":"7a19" - }, - { - "sim":53.0, - "partner":"7a1a" - }, - { - "sim":53.0, - "partner":"7a53" - }, - { - "sim":53.0, - "partner":"7ajw" - }, - { - "sim":53.0, - "partner":"7akb" + "partner":"7ajm" }, { "sim":53.0, - "partner":"7ajy" + "partner":"7a19" }, { "sim":53.0, - "partner":"7a5l" + "partner":"7a1a" }, { "sim":53.0, @@ -717014,21 +719953,37 @@ "sim":53.0, "partner":"7aka" }, + { + "sim":53.0, + "partner":"7a53" + }, { "sim":53.0, "partner":"7akl" }, { "sim":53.0, - "partner":"8tne" + "partner":"7ajw" }, { "sim":53.0, - "partner":"4aub" + "partner":"7akb" }, { "sim":53.0, - "partner":"8ixa" + "partner":"7ajy" + }, + { + "sim":53.0, + "partner":"7a5l" + }, + { + "sim":53.0, + "partner":"8tne" + }, + { + "sim":53.0, + "partner":"4aub" }, { "sim":53.0, @@ -717050,6 +720005,10 @@ "sim":53.0, "partner":"8ixg" }, + { + "sim":53.0, + "partner":"8ixa" + }, { "sim":53.0, "partner":"7ugb" @@ -717084,11 +720043,11 @@ }, { "sim":53.0, - "partner":"4ak5" + "partner":"7k14" }, { "sim":53.0, - "partner":"7k14" + "partner":"4ak5" }, { "sim":53.0, @@ -717100,11 +720059,11 @@ }, { "sim":53.0, - "partner":"8hsv" + "partner":"8hst" }, { "sim":53.0, - "partner":"8hst" + "partner":"8hsv" }, { "sim":53.0, @@ -717160,11 +720119,11 @@ }, { "sim":53.0, - "partner":"6ak4" + "partner":"6aej" }, { "sim":53.0, - "partner":"6aej" + "partner":"6ak4" }, { "sim":53.0, @@ -717190,10 +720149,6 @@ "sim":53.0, "partner":"3khz" }, - { - "sim":53.0, - "partner":"4ie7" - }, { "sim":53.0, "partner":"4cxw" @@ -717212,15 +720167,15 @@ }, { "sim":53.0, - "partner":"4idz" + "partner":"7e8z" }, { "sim":53.0, - "partner":"4ie0" + "partner":"4idz" }, { "sim":53.0, - "partner":"7e8z" + "partner":"4ie0" }, { "sim":53.0, @@ -717240,15 +720195,15 @@ }, { "sim":53.0, - "partner":"7oze" + "partner":"4ie7" }, { "sim":53.0, - "partner":"7ozc" + "partner":"7oze" }, { "sim":53.0, - "partner":"2cj9" + "partner":"7ozc" }, { "sim":53.0, @@ -717262,6 +720217,10 @@ "sim":53.0, "partner":"2cjb" }, + { + "sim":53.0, + "partner":"2cj9" + }, { "sim":53.0, "partner":"6d23" @@ -717288,15 +720247,15 @@ }, { "sim":53.0, - "partner":"2vbg" + "partner":"2vbf" }, { "sim":53.0, - "partner":"2vbf" + "partner":"2vbg" }, { "sim":53.0, - "partner":"5m12" + "partner":"6gwg" }, { "sim":53.0, @@ -717304,31 +720263,31 @@ }, { "sim":53.0, - "partner":"6gwf" + "partner":"6gta" }, { "sim":53.0, - "partner":"6gwg" + "partner":"5m16" }, { "sim":53.0, - "partner":"5m16" + "partner":"6gvd" }, { "sim":53.0, - "partner":"6gta" + "partner":"5m0x" }, { "sim":53.0, - "partner":"6gvd" + "partner":"6gx8" }, { "sim":53.0, - "partner":"5m0x" + "partner":"5m12" }, { "sim":53.0, - "partner":"6gx8" + "partner":"6gwf" }, { "sim":53.0, @@ -717374,21 +720333,17 @@ "sim":53.0, "partner":"2bn4" }, - { - "sim":53.0, - "partner":"3o8y" - }, { "sim":53.0, "partner":"7ttj" }, { "sim":53.0, - "partner":"7ttk" + "partner":"6n2w" }, { "sim":53.0, - "partner":"6n2w" + "partner":"7ttk" }, { "sim":53.0, @@ -717412,11 +720367,7 @@ }, { "sim":53.0, - "partner":"7vzz" - }, - { - "sim":53.0, - "partner":"7vzu" + "partner":"3o8y" }, { "sim":53.0, @@ -717430,6 +720381,14 @@ "sim":53.0, "partner":"7vzy" }, + { + "sim":53.0, + "partner":"7vzz" + }, + { + "sim":53.0, + "partner":"7vzu" + }, { "sim":53.0, "partner":"5swi" @@ -717520,15 +720479,15 @@ }, { "sim":52.0, - "partner":"3qna" + "partner":"3qn0" }, { "sim":52.0, - "partner":"3qn0" + "partner":"3qn9" }, { "sim":52.0, - "partner":"3qn9" + "partner":"3qna" }, { "sim":52.0, @@ -717554,14 +720513,6 @@ "sim":52.0, "partner":"5b13" }, - { - "sim":52.0, - "partner":"5scp" - }, - { - "sim":52.0, - "partner":"5scq" - }, { "sim":52.0, "partner":"5scr" @@ -717664,7 +720615,11 @@ }, { "sim":52.0, - "partner":"1x24" + "partner":"5scp" + }, + { + "sim":52.0, + "partner":"5scq" }, { "sim":52.0, @@ -717672,15 +720627,15 @@ }, { "sim":52.0, - "partner":"3rz2" + "partner":"1x24" }, { "sim":52.0, - "partner":"2j8k" + "partner":"3rz2" }, { "sim":52.0, - "partner":"5l9k" + "partner":"2j8k" }, { "sim":52.0, @@ -717698,6 +720653,10 @@ "sim":52.0, "partner":"5lbp" }, + { + "sim":52.0, + "partner":"5l9k" + }, { "sim":52.0, "partner":"4b29" @@ -717708,11 +720667,11 @@ }, { "sim":52.0, - "partner":"1wc6" + "partner":"1wc1" }, { "sim":52.0, - "partner":"1wc1" + "partner":"1wc6" }, { "sim":52.0, @@ -717762,14 +720721,6 @@ "sim":52.0, "partner":"5dtz" }, - { - "sim":52.0, - "partner":"6tlm" - }, - { - "sim":52.0, - "partner":"6tlq" - }, { "sim":52.0, "partner":"6tlt" @@ -717802,6 +720753,14 @@ "sim":52.0, "partner":"6t50" }, + { + "sim":52.0, + "partner":"6tlm" + }, + { + "sim":52.0, + "partner":"6tlq" + }, { "sim":52.0, "partner":"5du0" @@ -717856,39 +720815,39 @@ }, { "sim":52.0, - "partner":"3quo" + "partner":"3qur" }, { "sim":52.0, - "partner":"3qvf" + "partner":"4rnj" }, { "sim":52.0, - "partner":"4rni" + "partner":"3qvh" }, { "sim":52.0, - "partner":"4rnj" + "partner":"3d40" }, { "sim":52.0, - "partner":"3qur" + "partner":"3d41" }, { "sim":52.0, - "partner":"3qvh" + "partner":"3qun" }, { "sim":52.0, - "partner":"3d40" + "partner":"3quo" }, { "sim":52.0, - "partner":"3d41" + "partner":"3qvf" }, { "sim":52.0, - "partner":"3qun" + "partner":"4rni" }, { "sim":52.0, @@ -717916,11 +720875,11 @@ }, { "sim":52.0, - "partner":"5okt" + "partner":"7nzy" }, { "sim":52.0, - "partner":"7nzy" + "partner":"5okt" }, { "sim":52.0, @@ -718072,15 +721031,15 @@ }, { "sim":52.0, - "partner":"5v59" + "partner":"4xem" }, { "sim":52.0, - "partner":"4xem" + "partner":"4xeo" }, { "sim":52.0, - "partner":"4xeo" + "partner":"5v59" }, { "sim":52.0, @@ -718104,11 +721063,11 @@ }, { "sim":52.0, - "partner":"1zdl" + "partner":"1zkq" }, { "sim":52.0, - "partner":"1zkq" + "partner":"1zdl" }, { "sim":52.0, @@ -718116,15 +721075,15 @@ }, { "sim":52.0, - "partner":"5kdn" + "partner":"5kds" }, { "sim":52.0, - "partner":"5kds" + "partner":"5kdu" }, { "sim":52.0, - "partner":"5kdu" + "partner":"5kdn" }, { "sim":52.0, @@ -718200,15 +721159,15 @@ }, { "sim":52.0, - "partner":"6jr8" + "partner":"6jr6" }, { "sim":52.0, - "partner":"6jr6" + "partner":"6jr7" }, { "sim":52.0, - "partner":"6jr7" + "partner":"6jr8" }, { "sim":52.0, @@ -718278,10 +721237,6 @@ "sim":51.0, "partner":"6aq7" }, - { - "sim":51.0, - "partner":"4hmr" - }, { "sim":51.0, "partner":"6t3o" @@ -718294,6 +721249,10 @@ "sim":51.0, "partner":"4hmm" }, + { + "sim":51.0, + "partner":"4hmr" + }, { "sim":51.0, "partner":"6g61" @@ -718324,23 +721283,23 @@ }, { "sim":51.0, - "partner":"3d7j" + "partner":"4nns" }, { "sim":51.0, - "partner":"5y0f" + "partner":"4nnt" }, { "sim":51.0, - "partner":"5y0g" + "partner":"6ljs" }, { "sim":51.0, - "partner":"4nns" + "partner":"6ljt" }, { "sim":51.0, - "partner":"4nnt" + "partner":"6lyw" }, { "sim":51.0, @@ -718348,7 +721307,7 @@ }, { "sim":51.0, - "partner":"6ljs" + "partner":"6lju" }, { "sim":51.0, @@ -718358,18 +721317,6 @@ "sim":51.0, "partner":"5y13" }, - { - "sim":51.0, - "partner":"6ljt" - }, - { - "sim":51.0, - "partner":"6lyw" - }, - { - "sim":51.0, - "partner":"6lju" - }, { "sim":51.0, "partner":"6ljv" @@ -718402,25 +721349,33 @@ "sim":51.0, "partner":"3q6l" }, + { + "sim":51.0, + "partner":"3d7j" + }, { "sim":51.0, "partner":"5y0x" }, { "sim":51.0, - "partner":"6lyx" + "partner":"5y0f" }, { "sim":51.0, - "partner":"2bze" + "partner":"5y0g" }, { "sim":51.0, - "partner":"3wbg" + "partner":"6lyx" }, { "sim":51.0, - "partner":"5hso" + "partner":"2bze" + }, + { + "sim":51.0, + "partner":"3wbg" }, { "sim":51.0, @@ -718440,7 +721395,7 @@ }, { "sim":51.0, - "partner":"3sw1" + "partner":"5hso" }, { "sim":51.0, @@ -718464,11 +721419,11 @@ }, { "sim":51.0, - "partner":"7r4s" + "partner":"6gg9" }, { "sim":51.0, - "partner":"6gg9" + "partner":"7r4s" }, { "sim":51.0, @@ -718476,11 +721431,11 @@ }, { "sim":51.0, - "partner":"5luv" + "partner":"3sw1" }, { "sim":51.0, - "partner":"5aoz" + "partner":"5luv" }, { "sim":51.0, @@ -718490,6 +721445,10 @@ "sim":51.0, "partner":"3ph4" }, + { + "sim":51.0, + "partner":"5aoz" + }, { "sim":51.0, "partner":"4oja" @@ -718500,23 +721459,23 @@ }, { "sim":51.0, - "partner":"7xtl" + "partner":"3l7u" }, { "sim":51.0, - "partner":"3l7u" + "partner":"3l20" }, { "sim":51.0, - "partner":"8oov" + "partner":"5ook" }, { "sim":51.0, - "partner":"3l20" + "partner":"8oov" }, { "sim":51.0, - "partner":"5ook" + "partner":"7xtl" }, { "sim":51.0, @@ -718548,11 +721507,11 @@ }, { "sim":51.0, - "partner":"4nsq" + "partner":"4f07" }, { "sim":51.0, - "partner":"4f07" + "partner":"4nsq" }, { "sim":51.0, @@ -718566,10 +721525,6 @@ "sim":51.0, "partner":"3p6b" }, - { - "sim":51.0, - "partner":"6f3z" - }, { "sim":51.0, "partner":"7q4s" @@ -718584,19 +721539,19 @@ }, { "sim":51.0, - "partner":"2d7j" + "partner":"6f3z" }, { "sim":51.0, - "partner":"6pj9" + "partner":"2d7j" }, { "sim":51.0, - "partner":"6pja" + "partner":"6pjp" }, { "sim":51.0, - "partner":"6pjp" + "partner":"6pjq" }, { "sim":51.0, @@ -718604,11 +721559,11 @@ }, { "sim":51.0, - "partner":"6pjq" + "partner":"6pjr" }, { "sim":51.0, - "partner":"6pjr" + "partner":"6pju" }, { "sim":51.0, @@ -718618,10 +721573,6 @@ "sim":51.0, "partner":"5f5d" }, - { - "sim":51.0, - "partner":"6pju" - }, { "sim":51.0, "partner":"4njp" @@ -718644,15 +721595,19 @@ }, { "sim":51.0, - "partner":"5f5j" + "partner":"6pj5" }, { "sim":51.0, - "partner":"6pj5" + "partner":"6pj7" }, { "sim":51.0, - "partner":"6pj7" + "partner":"5f5j" + }, + { + "sim":51.0, + "partner":"6pj8" }, { "sim":51.0, @@ -718660,7 +721615,11 @@ }, { "sim":51.0, - "partner":"6pj8" + "partner":"6pj9" + }, + { + "sim":51.0, + "partner":"6pja" }, { "sim":51.0, @@ -718700,15 +721659,15 @@ }, { "sim":51.0, - "partner":"6j0l" + "partner":"6j0g" }, { "sim":51.0, - "partner":"6j0g" + "partner":"6j0k" }, { "sim":51.0, - "partner":"6j0k" + "partner":"6j0l" }, { "sim":51.0, @@ -718732,23 +721691,23 @@ }, { "sim":51.0, - "partner":"8vip" + "partner":"8vit" }, { "sim":51.0, - "partner":"8viq" + "partner":"2xx3" }, { "sim":51.0, - "partner":"8vir" + "partner":"8vip" }, { "sim":51.0, - "partner":"8vit" + "partner":"8viq" }, { "sim":51.0, - "partner":"2xx3" + "partner":"8vir" }, { "sim":51.0, @@ -718772,7 +721731,7 @@ }, { "sim":51.0, - "partner":"7o2t" + "partner":"6z17" }, { "sim":51.0, @@ -718780,11 +721739,11 @@ }, { "sim":51.0, - "partner":"6z17" + "partner":"6yz3" }, { "sim":51.0, - "partner":"6yz3" + "partner":"6tpr" }, { "sim":51.0, @@ -718792,15 +721751,15 @@ }, { "sim":51.0, - "partner":"6tpr" + "partner":"6z07" }, { "sim":51.0, - "partner":"6z07" + "partner":"6z5k" }, { "sim":51.0, - "partner":"6z5k" + "partner":"7o2t" }, { "sim":51.0, @@ -718850,10 +721809,6 @@ "sim":51.0, "partner":"1e42" }, - { - "sim":51.0, - "partner":"5h5a" - }, { "sim":51.0, "partner":"3v3d" @@ -718866,6 +721821,10 @@ "sim":51.0, "partner":"5owf" }, + { + "sim":51.0, + "partner":"5h5a" + }, { "sim":51.0, "partner":"2cm1" @@ -718892,11 +721851,11 @@ }, { "sim":51.0, - "partner":"5du6" + "partner":"2ouk" }, { "sim":51.0, - "partner":"2ouk" + "partner":"5du6" }, { "sim":51.0, @@ -718952,23 +721911,23 @@ }, { "sim":51.0, - "partner":"6ub4" + "partner":"6ub2" }, { "sim":51.0, - "partner":"6ub5" + "partner":"6ub3" }, { "sim":51.0, - "partner":"6ub6" + "partner":"6ub4" }, { "sim":51.0, - "partner":"6ub2" + "partner":"6ub5" }, { "sim":51.0, - "partner":"6ub3" + "partner":"6ub6" }, { "sim":51.0, @@ -719008,24 +721967,12 @@ }, { "sim":51.0, - "partner":"5coq" - }, - { - "sim":51.0, - "partner":"5cpb" - }, - { - "sim":51.0, - "partner":"5mtr" + "partner":"4oxk" }, { "sim":51.0, "partner":"5ugt" }, - { - "sim":51.0, - "partner":"4oxk" - }, { "sim":51.0, "partner":"5ugu" @@ -719036,15 +721983,15 @@ }, { "sim":51.0, - "partner":"4oxn" + "partner":"6yuu" }, { "sim":51.0, - "partner":"4oyr" + "partner":"4oxn" }, { "sim":51.0, - "partner":"6yuu" + "partner":"4oyr" }, { "sim":51.0, @@ -719070,10 +722017,22 @@ "sim":51.0, "partner":"5cp8" }, + { + "sim":51.0, + "partner":"5mtr" + }, { "sim":51.0, "partner":"5ugs" }, + { + "sim":51.0, + "partner":"5cpb" + }, + { + "sim":51.0, + "partner":"5coq" + }, { "sim":51.0, "partner":"5zz3" @@ -719104,11 +722063,11 @@ }, { "sim":51.0, - "partner":"1xhl" + "partner":"6p7g" }, { "sim":51.0, - "partner":"6p7g" + "partner":"1xhl" }, { "sim":51.0, @@ -719122,10 +722081,6 @@ "sim":51.0, "partner":"8tms" }, - { - "sim":51.0, - "partner":"3s3h" - }, { "sim":51.0, "partner":"3s3k" @@ -719140,7 +722095,7 @@ }, { "sim":51.0, - "partner":"7xif" + "partner":"3s3h" }, { "sim":51.0, @@ -719156,7 +722111,7 @@ }, { "sim":51.0, - "partner":"3g3d" + "partner":"7xif" }, { "sim":51.0, @@ -719174,6 +722129,10 @@ "sim":51.0, "partner":"4hkp" }, + { + "sim":51.0, + "partner":"3g3d" + }, { "sim":51.0, "partner":"7e4m" @@ -719326,14 +722285,6 @@ "sim":51.0, "partner":"4xzz" }, - { - "sim":51.0, - "partner":"5gg5" - }, - { - "sim":51.0, - "partner":"5xd1" - }, { "sim":51.0, "partner":"5gg6" @@ -719346,6 +722297,10 @@ "sim":51.0, "partner":"5xd3" }, + { + "sim":51.0, + "partner":"6m6y" + }, { "sim":51.0, "partner":"5gg7" @@ -719356,11 +722311,11 @@ }, { "sim":51.0, - "partner":"5xd5" + "partner":"6m65" }, { "sim":51.0, - "partner":"6m6y" + "partner":"5xd5" }, { "sim":51.0, @@ -719370,10 +722325,6 @@ "sim":51.0, "partner":"5hos" }, - { - "sim":51.0, - "partner":"6m65" - }, { "sim":51.0, "partner":"5gg9" @@ -719404,15 +722355,19 @@ }, { "sim":51.0, - "partner":"7r2e" + "partner":"5gg5" }, { "sim":51.0, - "partner":"5v8y" + "partner":"5xd1" }, { "sim":51.0, - "partner":"5jyf" + "partner":"7r2e" + }, + { + "sim":51.0, + "partner":"5v8y" }, { "sim":51.0, @@ -719452,7 +722407,7 @@ }, { "sim":51.0, - "partner":"1vsu" + "partner":"5jyf" }, { "sim":51.0, @@ -719470,6 +722425,10 @@ "sim":51.0, "partner":"5eqn" }, + { + "sim":51.0, + "partner":"1vsu" + }, { "sim":51.0, "partner":"6nor" @@ -719530,10 +722489,6 @@ "sim":51.0, "partner":"4rct" }, - { - "sim":51.0, - "partner":"4m1i" - }, { "sim":51.0, "partner":"4d8f" @@ -719548,12 +722503,16 @@ }, { "sim":51.0, - "partner":"6eow" + "partner":"4m1i" }, { "sim":51.0, "partner":"4lxl" }, + { + "sim":51.0, + "partner":"6eow" + }, { "sim":51.0, "partner":"3wnb" @@ -719606,14 +722565,6 @@ "sim":51.0, "partner":"4ot7" }, - { - "sim":51.0, - "partner":"3pz9" - }, - { - "sim":51.0, - "partner":"6put" - }, { "sim":51.0, "partner":"6puw" @@ -719628,11 +722579,11 @@ }, { "sim":51.0, - "partner":"3dt1" + "partner":"6puy" }, { "sim":51.0, - "partner":"6puy" + "partner":"3dt1" }, { "sim":51.0, @@ -719642,6 +722593,10 @@ "sim":51.0, "partner":"3pzm" }, + { + "sim":51.0, + "partner":"6puz" + }, { "sim":51.0, "partner":"3pzn" @@ -719656,7 +722611,7 @@ }, { "sim":51.0, - "partner":"6puz" + "partner":"6put" }, { "sim":51.0, @@ -719664,7 +722619,7 @@ }, { "sim":51.0, - "partner":"6ojx" + "partner":"3pz9" }, { "sim":51.0, @@ -719696,16 +722651,20 @@ }, { "sim":51.0, - "partner":"7dmb" + "partner":"6ojx" }, { "sim":51.0, - "partner":"8bao" + "partner":"7dmb" }, { "sim":51.0, "partner":"5j8x" }, + { + "sim":51.0, + "partner":"8bao" + }, { "sim":51.0, "partner":"5tzb" @@ -719814,10 +722773,6 @@ "sim":51.0, "partner":"6n85" }, - { - "sim":51.0, - "partner":"4lre" - }, { "sim":51.0, "partner":"4lrf" @@ -719850,6 +722805,10 @@ "sim":51.0, "partner":"4lrd" }, + { + "sim":51.0, + "partner":"4lre" + }, { "sim":51.0, "partner":"2w7y" @@ -719900,27 +722859,27 @@ }, { "sim":51.0, - "partner":"6ry0" + "partner":"6ry5" }, { "sim":51.0, - "partner":"6ry1" + "partner":"6ry6" }, { "sim":51.0, - "partner":"6ry2" + "partner":"6ry7" }, { "sim":51.0, - "partner":"6ry5" + "partner":"6ry0" }, { "sim":51.0, - "partner":"6ry6" + "partner":"6ry1" }, { "sim":51.0, - "partner":"6ry7" + "partner":"6ry2" }, { "sim":51.0, @@ -719948,11 +722907,11 @@ }, { "sim":51.0, - "partner":"8il0" + "partner":"8ila" }, { "sim":51.0, - "partner":"8ila" + "partner":"8il0" }, { "sim":51.0, @@ -719960,15 +722919,15 @@ }, { "sim":51.0, - "partner":"5v1s" + "partner":"5v1t" }, { "sim":51.0, - "partner":"5v1t" + "partner":"8s9i" }, { "sim":51.0, - "partner":"8s9i" + "partner":"8gme" }, { "sim":51.0, @@ -719976,11 +722935,11 @@ }, { "sim":51.0, - "partner":"8gme" + "partner":"5v1q" }, { "sim":51.0, - "partner":"5v1q" + "partner":"5v1s" }, { "sim":51.0, @@ -720064,15 +723023,15 @@ }, { "sim":51.0, - "partner":"4l2h" + "partner":"4epp" }, { "sim":51.0, - "partner":"4epp" + "partner":"4epq" }, { "sim":51.0, - "partner":"4epq" + "partner":"4l2h" }, { "sim":51.0, @@ -720090,10 +723049,6 @@ "sim":51.0, "partner":"5t3b" }, - { - "sim":51.0, - "partner":"6rk2" - }, { "sim":51.0, "partner":"6rjo" @@ -720108,19 +723063,19 @@ }, { "sim":51.0, - "partner":"6jmw" + "partner":"6rk2" }, { "sim":51.0, - "partner":"6jzs" + "partner":"6jmw" }, { "sim":51.0, - "partner":"5l77" + "partner":"6jzs" }, { "sim":51.0, - "partner":"6pt4" + "partner":"5l77" }, { "sim":51.0, @@ -720134,6 +723089,10 @@ "sim":51.0, "partner":"6ptk" }, + { + "sim":51.0, + "partner":"6pt4" + }, { "sim":51.0, "partner":"6rim" @@ -720288,27 +723247,27 @@ }, { "sim":51.0, - "partner":"4ids" + "partner":"4lem" }, { "sim":51.0, - "partner":"4jdc" + "partner":"4idm" }, { "sim":51.0, - "partner":"4lem" + "partner":"4ns3" }, { "sim":51.0, - "partner":"4idm" + "partner":"4ihi" }, { "sim":51.0, - "partner":"4ns3" + "partner":"4ids" }, { "sim":51.0, - "partner":"4ihi" + "partner":"4jdc" }, { "sim":51.0, @@ -720336,15 +723295,15 @@ }, { "sim":51.0, - "partner":"5tsh" + "partner":"6olj" }, { "sim":51.0, - "partner":"6olj" + "partner":"5tsg" }, { "sim":51.0, - "partner":"5tsg" + "partner":"5tsh" }, { "sim":51.0, @@ -720360,11 +723319,11 @@ }, { "sim":51.0, - "partner":"7jwf" + "partner":"7jw4" }, { "sim":51.0, - "partner":"7jw4" + "partner":"7jwf" }, { "sim":51.0, @@ -720384,15 +723343,15 @@ }, { "sim":51.0, - "partner":"6k8s" + "partner":"6k8t" }, { "sim":51.0, - "partner":"6k8t" + "partner":"6k8u" }, { "sim":51.0, - "partner":"6k8u" + "partner":"6k8s" }, { "sim":51.0, @@ -720410,10 +723369,6 @@ "sim":51.0, "partner":"5x7h" }, - { - "sim":51.0, - "partner":"7wlg" - }, { "sim":51.0, "partner":"7wj9" @@ -720444,23 +723399,19 @@ }, { "sim":51.0, - "partner":"7p1g" - }, - { - "sim":51.0, - "partner":"3slk" + "partner":"7wlg" }, { "sim":51.0, - "partner":"7p1h" + "partner":"7p1g" }, { "sim":51.0, - "partner":"4j3t" + "partner":"3slk" }, { "sim":51.0, - "partner":"4j3u" + "partner":"7p1h" }, { "sim":51.0, @@ -720480,7 +723431,11 @@ }, { "sim":51.0, - "partner":"5y1h" + "partner":"4j3t" + }, + { + "sim":51.0, + "partner":"4j3u" }, { "sim":51.0, @@ -720526,6 +723481,10 @@ "sim":51.0, "partner":"5y3i" }, + { + "sim":51.0, + "partner":"5y1h" + }, { "sim":51.0, "partner":"7s6b" @@ -720684,11 +723643,11 @@ }, { "sim":50.0, - "partner":"6tq2" + "partner":"6tq1" }, { "sim":50.0, - "partner":"6tq1" + "partner":"6tq2" }, { "sim":50.0, @@ -720722,10 +723681,6 @@ "sim":50.0, "partner":"6okn" }, - { - "sim":50.0, - "partner":"3v57" - }, { "sim":50.0, "partner":"7y1a" @@ -720742,6 +723697,10 @@ "sim":50.0, "partner":"8b4n" }, + { + "sim":50.0, + "partner":"3v57" + }, { "sim":50.0, "partner":"4yxl" @@ -720752,11 +723711,11 @@ }, { "sim":50.0, - "partner":"2wja" + "partner":"7a6p" }, { "sim":50.0, - "partner":"7a6p" + "partner":"2wja" }, { "sim":50.0, @@ -720764,15 +723723,15 @@ }, { "sim":50.0, - "partner":"7r5n" + "partner":"4ip3" }, { "sim":50.0, - "partner":"4ip3" + "partner":"7r5n" }, { "sim":50.0, - "partner":"5edd" + "partner":"8p8o" }, { "sim":50.0, @@ -720800,15 +723759,15 @@ }, { "sim":50.0, - "partner":"8p8o" + "partner":"1sm8" }, { "sim":50.0, - "partner":"1sm8" + "partner":"3hza" }, { "sim":50.0, - "partner":"3hza" + "partner":"5edd" }, { "sim":50.0, @@ -720852,15 +723811,15 @@ }, { "sim":50.0, - "partner":"4gzc" + "partner":"4gzd" }, { "sim":50.0, - "partner":"4gzd" + "partner":"7eh9" }, { "sim":50.0, - "partner":"7eh9" + "partner":"4gzc" }, { "sim":50.0, @@ -720954,10 +723913,6 @@ "sim":50.0, "partner":"2gcp" }, - { - "sim":50.0, - "partner":"3th5" - }, { "sim":50.0, "partner":"4gzl" @@ -720976,7 +723931,7 @@ }, { "sim":50.0, - "partner":"3l1u" + "partner":"3th5" }, { "sim":50.0, @@ -720998,6 +723953,10 @@ "sim":50.0, "partner":"3esr" }, + { + "sim":50.0, + "partner":"3l1u" + }, { "sim":50.0, "partner":"2l22" @@ -721012,11 +723971,11 @@ }, { "sim":50.0, - "partner":"3umf" + "partner":"7fe5" }, { "sim":50.0, - "partner":"7fe5" + "partner":"3umf" }, { "sim":50.0, @@ -721032,15 +723991,15 @@ }, { "sim":50.0, - "partner":"6a98" + "partner":"6a99" }, { "sim":50.0, - "partner":"6a99" + "partner":"6a9f" }, { "sim":50.0, - "partner":"6a9f" + "partner":"6a98" }, { "sim":50.0, @@ -721072,31 +724031,31 @@ }, { "sim":50.0, - "partner":"7mnq" + "partner":"7mns" }, { "sim":50.0, - "partner":"7mnr" + "partner":"7mnt" }, { "sim":50.0, - "partner":"7mns" + "partner":"4irb" }, { "sim":50.0, - "partner":"4irb" + "partner":"7mnu" }, { "sim":50.0, - "partner":"7mnt" + "partner":"7mnv" }, { "sim":50.0, - "partner":"7mnu" + "partner":"7mnq" }, { "sim":50.0, - "partner":"7mnv" + "partner":"7mnr" }, { "sim":50.0, @@ -721142,10 +724101,6 @@ "sim":50.0, "partner":"4zb1" }, - { - "sim":50.0, - "partner":"4da6" - }, { "sim":50.0, "partner":"4da7" @@ -721200,15 +724155,19 @@ }, { "sim":50.0, - "partner":"2dps" + "partner":"4da6" }, { "sim":50.0, - "partner":"2dpt" + "partner":"8bat" }, { "sim":50.0, - "partner":"8bat" + "partner":"2dps" + }, + { + "sim":50.0, + "partner":"2dpt" }, { "sim":50.0, @@ -721270,10 +724229,6 @@ "sim":50.0, "partner":"5m09" }, - { - "sim":50.0, - "partner":"3dbp" - }, { "sim":50.0, "partner":"3mo7" @@ -721296,23 +724251,27 @@ }, { "sim":50.0, - "partner":"6t2p" + "partner":"3dbp" }, { "sim":50.0, - "partner":"2wk1" + "partner":"6akv" }, { "sim":50.0, - "partner":"6t2q" + "partner":"6t2o" }, { "sim":50.0, - "partner":"6akv" + "partner":"6t2p" }, { "sim":50.0, - "partner":"6t2o" + "partner":"6t2q" + }, + { + "sim":50.0, + "partner":"2wk1" }, { "sim":50.0, @@ -721376,19 +724335,19 @@ }, { "sim":50.0, - "partner":"5lsg" + "partner":"6t9c" }, { "sim":50.0, - "partner":"6t9c" + "partner":"5lsg" }, { "sim":50.0, - "partner":"5l45" + "partner":"6qj5" }, { "sim":50.0, - "partner":"6qj5" + "partner":"5l45" }, { "sim":50.0, @@ -721404,11 +724363,11 @@ }, { "sim":50.0, - "partner":"6y5x" + "partner":"6y5y" }, { "sim":50.0, - "partner":"6y5y" + "partner":"6y5x" }, { "sim":50.0, @@ -721430,10 +724389,6 @@ "sim":50.0, "partner":"2qj3" }, - { - "sim":50.0, - "partner":"3aio" - }, { "sim":50.0, "partner":"3aik" @@ -721454,6 +724409,10 @@ "sim":50.0, "partner":"3ain" }, + { + "sim":50.0, + "partner":"3aio" + }, { "sim":50.0, "partner":"6t2n" @@ -721464,19 +724423,19 @@ }, { "sim":50.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":50.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":50.0, - "partner":"3tm8" + "partner":"3tmc" }, { "sim":50.0, - "partner":"3tmb" + "partner":"3tmd" }, { "sim":50.0, @@ -721486,10 +724445,6 @@ "sim":50.0, "partner":"3rlh" }, - { - "sim":50.0, - "partner":"2pzm" - }, { "sim":50.0, "partner":"2qry" @@ -721504,12 +724459,16 @@ }, { "sim":50.0, - "partner":"6lcn" + "partner":"2pzm" }, { "sim":50.0, "partner":"7x1l" }, + { + "sim":50.0, + "partner":"6lcn" + }, { "sim":50.0, "partner":"7f8d" @@ -721540,23 +724499,23 @@ }, { "sim":50.0, - "partner":"6q4x" + "partner":"6q4z" }, { "sim":50.0, - "partner":"6q4y" + "partner":"5zci" }, { "sim":50.0, - "partner":"6q4z" + "partner":"5zcm" }, { "sim":50.0, - "partner":"5zci" + "partner":"6q4x" }, { "sim":50.0, - "partner":"5zcm" + "partner":"6q4y" }, { "sim":50.0, @@ -721622,18 +724581,6 @@ "sim":50.0, "partner":"4ilk" }, - { - "sim":50.0, - "partner":"4m25" - }, - { - "sim":50.0, - "partner":"4m2i" - }, - { - "sim":50.0, - "partner":"4ne0" - }, { "sim":50.0, "partner":"4m26" @@ -721670,6 +724617,18 @@ "sim":50.0, "partner":"4m2g" }, + { + "sim":50.0, + "partner":"4m25" + }, + { + "sim":50.0, + "partner":"4m2i" + }, + { + "sim":50.0, + "partner":"4ne0" + }, { "sim":50.0, "partner":"7us5" @@ -721740,31 +724699,31 @@ }, { "sim":50.0, - "partner":"6zgp" + "partner":"6y9d" }, { "sim":50.0, - "partner":"6y8j" + "partner":"6zgp" }, { "sim":50.0, - "partner":"6y9c" + "partner":"2qap" }, { "sim":50.0, - "partner":"6y9d" + "partner":"6y8s" }, { "sim":50.0, - "partner":"2qap" + "partner":"2qdg" }, { "sim":50.0, - "partner":"6y8s" + "partner":"6y8j" }, { "sim":50.0, - "partner":"2qdg" + "partner":"6y9c" }, { "sim":50.0, @@ -721840,11 +724799,7 @@ }, { "sim":50.0, - "partner":"5dvi" - }, - { - "sim":50.0, - "partner":"5xw2" + "partner":"4e2p" }, { "sim":50.0, @@ -721852,11 +724807,11 @@ }, { "sim":50.0, - "partner":"4e2p" + "partner":"3ssm" }, { "sim":50.0, - "partner":"3ssm" + "partner":"8d19" }, { "sim":50.0, @@ -721864,16 +724819,12 @@ }, { "sim":50.0, - "partner":"8d19" + "partner":"8czk" }, { "sim":50.0, "partner":"3sso" }, - { - "sim":50.0, - "partner":"8czk" - }, { "sim":50.0, "partner":"8czl" @@ -721886,6 +724837,14 @@ "sim":50.0, "partner":"5dvf" }, + { + "sim":50.0, + "partner":"5dvi" + }, + { + "sim":50.0, + "partner":"5xw2" + }, { "sim":50.0, "partner":"3zu2" @@ -721924,15 +724883,15 @@ }, { "sim":50.0, - "partner":"5z8a" + "partner":"5z8k" }, { "sim":50.0, - "partner":"5z8k" + "partner":"5z83" }, { "sim":50.0, - "partner":"5z83" + "partner":"5z8a" }, { "sim":50.0, @@ -722026,10 +724985,6 @@ "sim":50.0, "partner":"6qps" }, - { - "sim":50.0, - "partner":"2wc4" - }, { "sim":50.0, "partner":"1oif" @@ -722142,6 +725097,10 @@ "sim":50.0, "partner":"1uz1" }, + { + "sim":50.0, + "partner":"2wc4" + }, { "sim":50.0, "partner":"6j0u" @@ -722230,10 +725189,6 @@ "sim":50.0, "partner":"4ife" }, - { - "sim":50.0, - "partner":"5uno" - }, { "sim":50.0, "partner":"7m7c" @@ -722252,11 +725207,11 @@ }, { "sim":50.0, - "partner":"4l6w" + "partner":"5uno" }, { "sim":50.0, - "partner":"6x0h" + "partner":"4l6w" }, { "sim":50.0, @@ -722266,6 +725221,10 @@ "sim":50.0, "partner":"6x0k" }, + { + "sim":50.0, + "partner":"6x0h" + }, { "sim":50.0, "partner":"6pop" @@ -722288,11 +725247,11 @@ }, { "sim":50.0, - "partner":"7an1" + "partner":"7oqd" }, { "sim":50.0, - "partner":"7oqd" + "partner":"7an1" }, { "sim":50.0, @@ -722344,15 +725303,15 @@ }, { "sim":50.0, - "partner":"7mdl" + "partner":"8g9z" }, { "sim":50.0, - "partner":"8g9z" + "partner":"7l1t" }, { "sim":50.0, - "partner":"7l1t" + "partner":"7mdl" }, { "sim":50.0, @@ -722376,47 +725335,47 @@ }, { "sim":50.0, - "partner":"8aq3" + "partner":"7aci" }, { "sim":50.0, - "partner":"8aq4" + "partner":"8b0k" }, { "sim":50.0, - "partner":"7aci" + "partner":"8b0l" }, { "sim":50.0, - "partner":"8b0k" + "partner":"8b0m" }, { "sim":50.0, - "partner":"5n6h" + "partner":"8b0n" }, { "sim":50.0, - "partner":"8b0l" + "partner":"5n6h" }, { "sim":50.0, - "partner":"8b0m" + "partner":"8b0o" }, { "sim":50.0, - "partner":"8b0n" + "partner":"8b0p" }, { "sim":50.0, - "partner":"8b0o" + "partner":"5n6l" }, { "sim":50.0, - "partner":"8b0p" + "partner":"8aq3" }, { "sim":50.0, - "partner":"5n6l" + "partner":"8aq4" }, { "sim":50.0, @@ -722548,15 +725507,15 @@ }, { "sim":50.0, - "partner":"7w1c" + "partner":"7w1d" }, { "sim":50.0, - "partner":"7w1d" + "partner":"7w1e" }, { "sim":50.0, - "partner":"7w1e" + "partner":"7w1c" }, { "sim":50.0, @@ -722628,15 +725587,15 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"6edz" }, { "sim":50.0, - "partner":"6edz" + "partner":"6ee1" }, { "sim":50.0, - "partner":"6ee1" + "partner":"6edw" }, { "sim":50.0, @@ -722728,10 +725687,10 @@ ], "subtitle":"A near-infrared fluorescent protein of de novo backbone design", "tags":[ - "de novo backbone design", "monomerization", "de novo protein", - "near-infrared fluorescent protein" + "near-infrared fluorescent protein", + "de novo backbone design" ], "keywords":[ "description", @@ -722784,11 +725743,11 @@ }, { "sim":77.0, - "partner":"8jpa" + "partner":"8hdv" }, { "sim":77.0, - "partner":"8hdv" + "partner":"8jpa" }, { "sim":74.0, @@ -722808,7 +725767,7 @@ }, { "sim":51.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":51.0, @@ -722816,15 +725775,15 @@ }, { "sim":51.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":51.0, - "partner":"8w08" + "partner":"8w06" }, { "sim":51.0, - "partner":"8w05" + "partner":"8v0a" }, { "sim":51.0, @@ -722832,11 +725791,11 @@ }, { "sim":50.0, - "partner":"8v2w" + "partner":"8v09" }, { "sim":50.0, - "partner":"8v09" + "partner":"8v2w" } ], "seq_thr_sim_natural":[ @@ -722862,15 +725821,15 @@ }, { "sim":140.0, - "partner":"7sc9" + "partner":"7sc7" }, { "sim":140.0, - "partner":"7sc7" + "partner":"7scb" }, { "sim":140.0, - "partner":"7scb" + "partner":"7sc9" }, { "sim":138.0, @@ -722878,23 +725837,23 @@ }, { "sim":136.0, - "partner":"6kgx" + "partner":"7ezx" }, { "sim":136.0, - "partner":"7y7a" + "partner":"7y4l" }, { "sim":136.0, - "partner":"7ezx" + "partner":"7y5e" }, { "sim":136.0, - "partner":"7y4l" + "partner":"6kgx" }, { "sim":136.0, - "partner":"7y5e" + "partner":"7y7a" }, { "sim":132.0, @@ -722998,11 +725957,11 @@ }, { "sim":76.0, - "partner":"7y0k" + "partner":"7xwu" }, { "sim":76.0, - "partner":"7xwu" + "partner":"7y0k" }, { "sim":75.0, @@ -723028,10 +725987,6 @@ "sim":75.0, "partner":"3roj" }, - { - "sim":75.0, - "partner":"3nc3" - }, { "sim":75.0, "partner":"3nc5" @@ -723044,6 +725999,10 @@ "sim":75.0, "partner":"3nc7" }, + { + "sim":75.0, + "partner":"3nc3" + }, { "sim":75.0, "partner":"4h5y" @@ -723068,18 +726027,6 @@ "sim":74.0, "partner":"3s2s" }, - { - "sim":74.0, - "partner":"7ex2" - }, - { - "sim":74.0, - "partner":"7ex3" - }, - { - "sim":74.0, - "partner":"7ex4" - }, { "sim":74.0, "partner":"7ex6" @@ -723128,6 +726075,18 @@ "sim":74.0, "partner":"7ex1" }, + { + "sim":74.0, + "partner":"7ex2" + }, + { + "sim":74.0, + "partner":"7ex3" + }, + { + "sim":74.0, + "partner":"7ex4" + }, { "sim":74.0, "partner":"5u4z" @@ -723256,10 +726215,6 @@ "sim":73.0, "partner":"6wyn" }, - { - "sim":73.0, - "partner":"7dw8" - }, { "sim":73.0, "partner":"7dwa" @@ -723278,15 +726233,15 @@ }, { "sim":73.0, - "partner":"4y0x" + "partner":"7dw8" }, { "sim":73.0, - "partner":"4y12" + "partner":"4y0x" }, { "sim":73.0, - "partner":"6jtl" + "partner":"4y12" }, { "sim":73.0, @@ -723302,19 +726257,19 @@ }, { "sim":73.0, - "partner":"4lit" + "partner":"6jtl" }, { "sim":73.0, - "partner":"4liu" + "partner":"4lit" }, { "sim":73.0, - "partner":"4liv" + "partner":"4liu" }, { "sim":73.0, - "partner":"3pln" + "partner":"4liv" }, { "sim":73.0, @@ -723328,6 +726283,10 @@ "sim":73.0, "partner":"3pjg" }, + { + "sim":73.0, + "partner":"3pln" + }, { "sim":73.0, "partner":"5gvx" @@ -723358,28 +726317,20 @@ }, { "sim":73.0, - "partner":"6unz" - }, - { - "sim":73.0, - "partner":"6uoj" + "partner":"6msn" }, { "sim":73.0, - "partner":"6upo" + "partner":"6unz" }, { "sim":73.0, - "partner":"6msn" + "partner":"6uq8" }, { "sim":73.0, "partner":"5l2r" }, - { - "sim":73.0, - "partner":"6uq8" - }, { "sim":73.0, "partner":"6uo0" @@ -723416,17 +726367,25 @@ "sim":73.0, "partner":"6up9" }, + { + "sim":73.0, + "partner":"6uoj" + }, + { + "sim":73.0, + "partner":"6upo" + }, { "sim":72.0, "partner":"6hrk" }, { "sim":72.0, - "partner":"6isk" + "partner":"6isl" }, { "sim":72.0, - "partner":"6isl" + "partner":"6isk" }, { "sim":72.0, @@ -723512,10 +726471,6 @@ "sim":72.0, "partner":"3wg8" }, - { - "sim":72.0, - "partner":"2uxx" - }, { "sim":72.0, "partner":"2iw5" @@ -723528,6 +726483,10 @@ "sim":72.0, "partner":"4kum" }, + { + "sim":72.0, + "partner":"2uxx" + }, { "sim":72.0, "partner":"7vxo" @@ -723608,10 +726567,6 @@ "sim":72.0, "partner":"6ddn" }, - { - "sim":72.0, - "partner":"3tro" - }, { "sim":72.0, "partner":"3tjx" @@ -723624,6 +726579,10 @@ "sim":72.0, "partner":"7myd" }, + { + "sim":72.0, + "partner":"3tro" + }, { "sim":72.0, "partner":"7m4s" @@ -723650,27 +726609,27 @@ }, { "sim":72.0, - "partner":"6alm" + "partner":"6alo" }, { "sim":72.0, - "partner":"6aln" + "partner":"6alp" }, { "sim":72.0, - "partner":"6alo" + "partner":"6alq" }, { "sim":72.0, - "partner":"6alp" + "partner":"6alr" }, { "sim":72.0, - "partner":"6alq" + "partner":"6alm" }, { "sim":72.0, - "partner":"6alr" + "partner":"6aln" }, { "sim":72.0, @@ -723738,11 +726697,11 @@ }, { "sim":72.0, - "partner":"4nxl" + "partner":"4jek" }, { "sim":72.0, - "partner":"4jek" + "partner":"4nxl" }, { "sim":72.0, @@ -723776,6 +726735,18 @@ "sim":72.0, "partner":"6lkc" }, + { + "sim":72.0, + "partner":"8vjq" + }, + { + "sim":72.0, + "partner":"8vix" + }, + { + "sim":72.0, + "partner":"8vh0" + }, { "sim":72.0, "partner":"6jym" @@ -723846,11 +726817,11 @@ }, { "sim":71.0, - "partner":"6mwy" + "partner":"6myl" }, { "sim":71.0, - "partner":"6myl" + "partner":"6mwy" }, { "sim":71.0, @@ -723878,11 +726849,11 @@ }, { "sim":71.0, - "partner":"3la8" + "partner":"3lba" }, { "sim":71.0, - "partner":"3lba" + "partner":"3la8" }, { "sim":71.0, @@ -723962,23 +726933,23 @@ }, { "sim":71.0, - "partner":"7ffg" + "partner":"7ffi" }, { "sim":71.0, - "partner":"7ffh" + "partner":"7ffa" }, { "sim":71.0, - "partner":"7ffi" + "partner":"7ffc" }, { "sim":71.0, - "partner":"7ffa" + "partner":"7ffg" }, { "sim":71.0, - "partner":"7ffc" + "partner":"7ffh" }, { "sim":71.0, @@ -724030,11 +727001,11 @@ }, { "sim":71.0, - "partner":"3l7r" + "partner":"3t0c" }, { "sim":71.0, - "partner":"3t0c" + "partner":"3l7r" }, { "sim":70.0, @@ -724068,10 +727039,6 @@ "sim":70.0, "partner":"3l1n" }, - { - "sim":70.0, - "partner":"4m02" - }, { "sim":70.0, "partner":"3zez" @@ -724108,6 +727075,10 @@ "sim":70.0, "partner":"5ffa" }, + { + "sim":70.0, + "partner":"4m02" + }, { "sim":70.0, "partner":"4e2a" @@ -724122,11 +727093,11 @@ }, { "sim":70.0, - "partner":"5nbt" + "partner":"6gzc" }, { "sim":70.0, - "partner":"6gzc" + "partner":"5nbt" }, { "sim":70.0, @@ -724152,10 +727123,6 @@ "sim":70.0, "partner":"4nod" }, - { - "sim":70.0, - "partner":"5nbh" - }, { "sim":70.0, "partner":"5n8d" @@ -724168,6 +727135,10 @@ "sim":70.0, "partner":"5n83" }, + { + "sim":70.0, + "partner":"5nbh" + }, { "sim":70.0, "partner":"3l87" @@ -724216,10 +727187,6 @@ "sim":70.0, "partner":"5ywt" }, - { - "sim":70.0, - "partner":"7eny" - }, { "sim":70.0, "partner":"8hp5" @@ -724234,19 +727201,23 @@ }, { "sim":70.0, - "partner":"5feu" + "partner":"7eny" }, { "sim":70.0, - "partner":"6pei" + "partner":"6pej" }, { "sim":70.0, - "partner":"6pej" + "partner":"6y4d" }, { "sim":70.0, - "partner":"6y4d" + "partner":"6pei" + }, + { + "sim":70.0, + "partner":"5feu" }, { "sim":70.0, @@ -724280,10 +727251,6 @@ "sim":70.0, "partner":"3b3d" }, - { - "sim":70.0, - "partner":"5yoi" - }, { "sim":70.0, "partner":"5ypj" @@ -724300,6 +727267,10 @@ "sim":70.0, "partner":"5yoh" }, + { + "sim":70.0, + "partner":"5yoi" + }, { "sim":70.0, "partner":"3p2m" @@ -724346,15 +727317,11 @@ }, { "sim":70.0, - "partner":"7cm8" - }, - { - "sim":70.0, - "partner":"7djq" + "partner":"7c35" }, { "sim":70.0, - "partner":"7c35" + "partner":"7ewo" }, { "sim":70.0, @@ -724370,12 +727337,16 @@ }, { "sim":70.0, - "partner":"7ewo" + "partner":"7cm8" }, { "sim":70.0, "partner":"5xcp" }, + { + "sim":70.0, + "partner":"7djq" + }, { "sim":70.0, "partner":"7cd5" @@ -724442,15 +727413,15 @@ }, { "sim":70.0, - "partner":"8uen" + "partner":"8uro" }, { "sim":70.0, - "partner":"8ura" + "partner":"8uen" }, { "sim":70.0, - "partner":"8uro" + "partner":"8ura" }, { "sim":70.0, @@ -724580,10 +727551,6 @@ "sim":69.0, "partner":"4jbh" }, - { - "sim":69.0, - "partner":"7q9z" - }, { "sim":69.0, "partner":"3udz" @@ -724606,15 +727573,15 @@ }, { "sim":69.0, - "partner":"5e0o" + "partner":"7q9z" }, { "sim":69.0, - "partner":"4e85" + "partner":"5e0o" }, { - "sim":68.0, - "partner":"3ul6" + "sim":69.0, + "partner":"4e85" }, { "sim":68.0, @@ -724622,7 +727589,7 @@ }, { "sim":68.0, - "partner":"4d1f" + "partner":"3ul6" }, { "sim":68.0, @@ -724632,6 +727599,10 @@ "sim":68.0, "partner":"4d0u" }, + { + "sim":68.0, + "partner":"4d1f" + }, { "sim":68.0, "partner":"5fld" @@ -724656,10 +727627,6 @@ "sim":68.0, "partner":"5zi0" }, - { - "sim":68.0, - "partner":"2zbb" - }, { "sim":68.0, "partner":"3e4o" @@ -724672,6 +727639,10 @@ "sim":68.0, "partner":"3e4q" }, + { + "sim":68.0, + "partner":"2zbb" + }, { "sim":68.0, "partner":"4nv7" @@ -724788,26 +727759,18 @@ "sim":67.0, "partner":"4f6l" }, - { - "sim":67.0, - "partner":"4bzc" - }, { "sim":67.0, "partner":"4qg1" }, { "sim":67.0, - "partner":"6dwk" + "partner":"6dwd" }, { "sim":67.0, "partner":"4qg2" }, - { - "sim":67.0, - "partner":"6dwd" - }, { "sim":67.0, "partner":"7s2y" @@ -724856,6 +727819,14 @@ "sim":67.0, "partner":"4qg0" }, + { + "sim":67.0, + "partner":"6dwk" + }, + { + "sim":67.0, + "partner":"4bzc" + }, { "sim":67.0, "partner":"8hhe" @@ -724878,15 +727849,15 @@ }, { "sim":65.0, - "partner":"2c7j" + "partner":"2c7k" }, { "sim":65.0, - "partner":"2c7k" + "partner":"2c7l" }, { "sim":65.0, - "partner":"2c7l" + "partner":"2c7j" }, { "sim":64.0, @@ -724962,31 +727933,31 @@ }, { "sim":60.0, - "partner":"7d6w" + "partner":"7sc8" }, { "sim":60.0, - "partner":"2uul" + "partner":"7sca" }, { "sim":60.0, - "partner":"7sc8" + "partner":"1gh0" }, { "sim":60.0, - "partner":"7sca" + "partner":"7d6w" }, { "sim":60.0, - "partner":"1gh0" + "partner":"2uum" }, { "sim":60.0, - "partner":"2uum" + "partner":"4f0t" }, { "sim":60.0, - "partner":"4f0t" + "partner":"2uul" }, { "sim":60.0, @@ -725030,20 +728001,12 @@ }, { "sim":58.0, - "partner":"6ypq" + "partner":"7eh7" }, { "sim":58.0, "partner":"7veb" }, - { - "sim":58.0, - "partner":"4gy3" - }, - { - "sim":58.0, - "partner":"4n6s" - }, { "sim":58.0, "partner":"3l0f" @@ -725054,11 +728017,11 @@ }, { "sim":58.0, - "partner":"1i7y" + "partner":"6xwk" }, { "sim":58.0, - "partner":"7eh7" + "partner":"7efv" }, { "sim":58.0, @@ -725066,27 +728029,23 @@ }, { "sim":58.0, - "partner":"6xwk" + "partner":"1i7y" }, { "sim":58.0, - "partner":"1jbo" + "partner":"8fwa" }, { "sim":58.0, "partner":"4gxe" }, - { - "sim":58.0, - "partner":"7efv" - }, { "sim":58.0, "partner":"1ktp" }, { "sim":58.0, - "partner":"8fwa" + "partner":"1jbo" }, { "sim":58.0, @@ -725098,19 +728057,19 @@ }, { "sim":58.0, - "partner":"4ziz" + "partner":"7efw" }, { "sim":58.0, - "partner":"1ha7" + "partner":"4ziz" }, { "sim":58.0, - "partner":"1on7" + "partner":"7eh8" }, { "sim":58.0, - "partner":"7efw" + "partner":"1on7" }, { "sim":58.0, @@ -725118,7 +728077,7 @@ }, { "sim":58.0, - "partner":"7eh8" + "partner":"1ha7" }, { "sim":58.0, @@ -725130,11 +728089,11 @@ }, { "sim":58.0, - "partner":"3o18" + "partner":"6yyj" }, { "sim":58.0, - "partner":"6yyj" + "partner":"3o18" }, { "sim":58.0, @@ -725148,13 +728107,25 @@ "sim":58.0, "partner":"5mjq" }, + { + "sim":58.0, + "partner":"6yq8" + }, { "sim":58.0, "partner":"5o7m" }, { "sim":58.0, - "partner":"6yq8" + "partner":"6ypq" + }, + { + "sim":58.0, + "partner":"4gy3" + }, + { + "sim":58.0, + "partner":"4n6s" }, { "sim":58.0, @@ -725186,11 +728157,11 @@ }, { "sim":57.0, - "partner":"6y3d" + "partner":"6hrn" }, { "sim":57.0, - "partner":"6hrn" + "partner":"6y3d" }, { "sim":57.0, @@ -725210,11 +728181,11 @@ }, { "sim":57.0, - "partner":"4mdo" + "partner":"4mdp" }, { "sim":57.0, - "partner":"4mdp" + "partner":"4mdo" }, { "sim":57.0, @@ -725334,7 +728305,7 @@ }, { "sim":55.0, - "partner":"4lm6" + "partner":"7tlf" }, { "sim":55.0, @@ -725342,7 +728313,7 @@ }, { "sim":55.0, - "partner":"7tlf" + "partner":"4lm6" }, { "sim":55.0, @@ -725378,11 +728349,11 @@ }, { "sim":55.0, - "partner":"4jqc" + "partner":"4jx8" }, { "sim":55.0, - "partner":"4jx8" + "partner":"4jqc" }, { "sim":55.0, @@ -725404,14 +728375,6 @@ "sim":55.0, "partner":"8t0u" }, - { - "sim":55.0, - "partner":"3dyh" - }, - { - "sim":55.0, - "partner":"4rxd" - }, { "sim":55.0, "partner":"4rxe" @@ -725454,48 +728417,40 @@ }, { "sim":55.0, - "partner":"2gqn" - }, - { - "sim":55.0, - "partner":"2fq6" + "partner":"4rxd" }, { "sim":55.0, - "partner":"5jk8" + "partner":"3dyh" }, { "sim":55.0, - "partner":"5jk5" + "partner":"2fq6" }, { "sim":55.0, - "partner":"5jk6" + "partner":"2gqn" }, { "sim":55.0, - "partner":"4wya" + "partner":"5jk8" }, { "sim":55.0, - "partner":"4wyf" + "partner":"5jk5" }, { "sim":55.0, - "partner":"4cxq" + "partner":"5jk6" }, { "sim":55.0, - "partner":"5kgs" + "partner":"4cxr" }, { "sim":55.0, "partner":"4wyg" }, - { - "sim":55.0, - "partner":"4cxr" - }, { "sim":55.0, "partner":"4xjl" @@ -725560,10 +728515,26 @@ "sim":55.0, "partner":"3tfu" }, + { + "sim":55.0, + "partner":"4wya" + }, { "sim":55.0, "partner":"4wye" }, + { + "sim":55.0, + "partner":"4wyf" + }, + { + "sim":55.0, + "partner":"4cxq" + }, + { + "sim":55.0, + "partner":"5kgs" + }, { "sim":55.0, "partner":"7jrl" @@ -725594,15 +728565,15 @@ }, { "sim":54.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":54.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":54.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":54.0, @@ -725644,33 +728615,29 @@ "sim":54.0, "partner":"6e4e" }, - { - "sim":54.0, - "partner":"4f0v" - }, { "sim":54.0, "partner":"4f0w" }, { "sim":54.0, - "partner":"3q6b" + "partner":"4f0v" }, { "sim":54.0, - "partner":"4bmx" + "partner":"3q6b" }, { "sim":54.0, - "partner":"4bmy" + "partner":"4bmz" }, { "sim":54.0, - "partner":"4bmz" + "partner":"4bmx" }, { "sim":54.0, - "partner":"6o98" + "partner":"4bmy" }, { "sim":54.0, @@ -725684,6 +728651,10 @@ "sim":54.0, "partner":"6xfv" }, + { + "sim":54.0, + "partner":"6o98" + }, { "sim":54.0, "partner":"2per" @@ -725708,14 +728679,6 @@ "sim":54.0, "partner":"4x7x" }, - { - "sim":54.0, - "partner":"7kqj" - }, - { - "sim":54.0, - "partner":"6vqf" - }, { "sim":54.0, "partner":"7kxd" @@ -725760,6 +728723,14 @@ "sim":54.0, "partner":"7luk" }, + { + "sim":54.0, + "partner":"6vqf" + }, + { + "sim":54.0, + "partner":"7kqj" + }, { "sim":54.0, "partner":"3g9g" @@ -725784,10 +728755,6 @@ "sim":54.0, "partner":"3u3j" }, - { - "sim":54.0, - "partner":"3u3r" - }, { "sim":54.0, "partner":"3u3k" @@ -725800,6 +728767,10 @@ "sim":54.0, "partner":"3u3o" }, + { + "sim":54.0, + "partner":"3u3r" + }, { "sim":54.0, "partner":"4j51" @@ -725822,11 +728793,11 @@ }, { "sim":54.0, - "partner":"7js3" + "partner":"8g5w" }, { "sim":54.0, - "partner":"8g5w" + "partner":"7js3" }, { "sim":54.0, @@ -725842,11 +728813,11 @@ }, { "sim":54.0, - "partner":"6wa9" + "partner":"6wa6" }, { "sim":54.0, - "partner":"6wa6" + "partner":"6wa9" }, { "sim":54.0, @@ -725874,11 +728845,11 @@ }, { "sim":54.0, - "partner":"5dt7" + "partner":"5dt5" }, { "sim":54.0, - "partner":"5dt5" + "partner":"5dt7" }, { "sim":54.0, @@ -725994,19 +728965,19 @@ }, { "sim":53.0, - "partner":"8b9b" + "partner":"8b9a" }, { "sim":53.0, - "partner":"6skl" + "partner":"8b9c" }, { "sim":53.0, - "partner":"8b9a" + "partner":"8b9b" }, { "sim":53.0, - "partner":"8b9c" + "partner":"6skl" }, { "sim":53.0, @@ -726056,10 +729027,6 @@ "sim":53.0, "partner":"5b1y" }, - { - "sim":53.0, - "partner":"1z5z" - }, { "sim":53.0, "partner":"2f9t" @@ -726070,12 +729037,16 @@ }, { "sim":53.0, - "partner":"5tii" + "partner":"1z5z" }, { "sim":53.0, "partner":"5thq" }, + { + "sim":53.0, + "partner":"5tii" + }, { "sim":53.0, "partner":"5c2d" @@ -726096,10 +729067,6 @@ "sim":53.0, "partner":"3uic" }, - { - "sim":53.0, - "partner":"4j3f" - }, { "sim":53.0, "partner":"4j4t" @@ -726112,6 +729079,10 @@ "sim":53.0, "partner":"4j1n" }, + { + "sim":53.0, + "partner":"4j3f" + }, { "sim":53.0, "partner":"5hii" @@ -726138,19 +729109,19 @@ }, { "sim":53.0, - "partner":"7a61" + "partner":"8rwq" }, { "sim":53.0, - "partner":"5uj3" + "partner":"6mnp" }, { "sim":53.0, - "partner":"5uj4" + "partner":"8rwr" }, { "sim":53.0, - "partner":"6mnp" + "partner":"5uj3" }, { "sim":53.0, @@ -726158,7 +729129,11 @@ }, { "sim":53.0, - "partner":"5ul8" + "partner":"8rws" + }, + { + "sim":53.0, + "partner":"5uj4" }, { "sim":53.0, @@ -726172,6 +729147,10 @@ "sim":53.0, "partner":"6d17" }, + { + "sim":53.0, + "partner":"5ul8" + }, { "sim":53.0, "partner":"6d18" @@ -726226,15 +729205,15 @@ }, { "sim":53.0, - "partner":"8rwq" + "partner":"6mey" }, { "sim":53.0, - "partner":"6mey" + "partner":"6v1j" }, { "sim":53.0, - "partner":"6v1j" + "partner":"8aki" }, { "sim":53.0, @@ -726242,7 +729221,7 @@ }, { "sim":53.0, - "partner":"8aki" + "partner":"8akj" }, { "sim":53.0, @@ -726254,7 +729233,7 @@ }, { "sim":53.0, - "partner":"8akj" + "partner":"8akk" }, { "sim":53.0, @@ -726262,27 +729241,27 @@ }, { "sim":53.0, - "partner":"8akk" + "partner":"8akl" }, { "sim":53.0, - "partner":"8akl" + "partner":"8akm" }, { "sim":53.0, - "partner":"8akm" + "partner":"7a61" }, { "sim":53.0, - "partner":"6loi" + "partner":"8rwo" }, { "sim":53.0, - "partner":"3p8e" + "partner":"8rwp" }, { "sim":53.0, - "partner":"7ulx" + "partner":"6loi" }, { "sim":53.0, @@ -726316,6 +729295,14 @@ "sim":53.0, "partner":"2otn" }, + { + "sim":53.0, + "partner":"3p8e" + }, + { + "sim":53.0, + "partner":"7ulx" + }, { "sim":53.0, "partner":"3utn" @@ -726338,24 +729325,20 @@ }, { "sim":53.0, - "partner":"4w7v" + "partner":"4w7u" }, { "sim":53.0, - "partner":"4w7w" + "partner":"4w7v" }, { "sim":53.0, - "partner":"4w7u" + "partner":"4w7w" }, { "sim":53.0, "partner":"7lh6" }, - { - "sim":53.0, - "partner":"7drp" - }, { "sim":53.0, "partner":"7drm" @@ -726368,6 +729351,10 @@ "sim":53.0, "partner":"7dro" }, + { + "sim":53.0, + "partner":"7drp" + }, { "sim":53.0, "partner":"5hnn" @@ -726392,10 +729379,6 @@ "sim":53.0, "partner":"8bft" }, - { - "sim":53.0, - "partner":"7ajm" - }, { "sim":53.0, "partner":"7a4r" @@ -726410,31 +729393,15 @@ }, { "sim":53.0, - "partner":"7a19" - }, - { - "sim":53.0, - "partner":"7a1a" - }, - { - "sim":53.0, - "partner":"7a53" - }, - { - "sim":53.0, - "partner":"7ajw" - }, - { - "sim":53.0, - "partner":"7akb" + "partner":"7ajm" }, { "sim":53.0, - "partner":"7ajy" + "partner":"7a19" }, { "sim":53.0, - "partner":"7a5l" + "partner":"7a1a" }, { "sim":53.0, @@ -726496,21 +729463,37 @@ "sim":53.0, "partner":"7aka" }, + { + "sim":53.0, + "partner":"7a53" + }, { "sim":53.0, "partner":"7akl" }, { "sim":53.0, - "partner":"8tne" + "partner":"7ajw" }, { "sim":53.0, - "partner":"4aub" + "partner":"7akb" }, { "sim":53.0, - "partner":"8ixa" + "partner":"7ajy" + }, + { + "sim":53.0, + "partner":"7a5l" + }, + { + "sim":53.0, + "partner":"8tne" + }, + { + "sim":53.0, + "partner":"4aub" }, { "sim":53.0, @@ -726532,6 +729515,10 @@ "sim":53.0, "partner":"8ixg" }, + { + "sim":53.0, + "partner":"8ixa" + }, { "sim":53.0, "partner":"7ugb" @@ -726566,11 +729553,11 @@ }, { "sim":53.0, - "partner":"4ak5" + "partner":"7k14" }, { "sim":53.0, - "partner":"7k14" + "partner":"4ak5" }, { "sim":53.0, @@ -726582,11 +729569,11 @@ }, { "sim":53.0, - "partner":"8hsv" + "partner":"8hst" }, { "sim":53.0, - "partner":"8hst" + "partner":"8hsv" }, { "sim":53.0, @@ -726642,11 +729629,11 @@ }, { "sim":53.0, - "partner":"6ak4" + "partner":"6aej" }, { "sim":53.0, - "partner":"6aej" + "partner":"6ak4" }, { "sim":53.0, @@ -726672,10 +729659,6 @@ "sim":53.0, "partner":"3khz" }, - { - "sim":53.0, - "partner":"4ie7" - }, { "sim":53.0, "partner":"4cxw" @@ -726694,15 +729677,15 @@ }, { "sim":53.0, - "partner":"4idz" + "partner":"7e8z" }, { "sim":53.0, - "partner":"4ie0" + "partner":"4idz" }, { "sim":53.0, - "partner":"7e8z" + "partner":"4ie0" }, { "sim":53.0, @@ -726722,15 +729705,15 @@ }, { "sim":53.0, - "partner":"7oze" + "partner":"4ie7" }, { "sim":53.0, - "partner":"7ozc" + "partner":"7oze" }, { "sim":53.0, - "partner":"2cj9" + "partner":"7ozc" }, { "sim":53.0, @@ -726744,6 +729727,10 @@ "sim":53.0, "partner":"2cjb" }, + { + "sim":53.0, + "partner":"2cj9" + }, { "sim":53.0, "partner":"6d23" @@ -726770,15 +729757,15 @@ }, { "sim":53.0, - "partner":"2vbg" + "partner":"2vbf" }, { "sim":53.0, - "partner":"2vbf" + "partner":"2vbg" }, { "sim":53.0, - "partner":"5m12" + "partner":"6gwg" }, { "sim":53.0, @@ -726786,31 +729773,31 @@ }, { "sim":53.0, - "partner":"6gwf" + "partner":"6gta" }, { "sim":53.0, - "partner":"6gwg" + "partner":"5m16" }, { "sim":53.0, - "partner":"5m16" + "partner":"6gvd" }, { "sim":53.0, - "partner":"6gta" + "partner":"5m0x" }, { "sim":53.0, - "partner":"6gvd" + "partner":"6gx8" }, { "sim":53.0, - "partner":"5m0x" + "partner":"5m12" }, { "sim":53.0, - "partner":"6gx8" + "partner":"6gwf" }, { "sim":53.0, @@ -726856,21 +729843,17 @@ "sim":53.0, "partner":"2bn4" }, - { - "sim":53.0, - "partner":"3o8y" - }, { "sim":53.0, "partner":"7ttj" }, { "sim":53.0, - "partner":"7ttk" + "partner":"6n2w" }, { "sim":53.0, - "partner":"6n2w" + "partner":"7ttk" }, { "sim":53.0, @@ -726894,11 +729877,7 @@ }, { "sim":53.0, - "partner":"7vzz" - }, - { - "sim":53.0, - "partner":"7vzu" + "partner":"3o8y" }, { "sim":53.0, @@ -726912,6 +729891,14 @@ "sim":53.0, "partner":"7vzy" }, + { + "sim":53.0, + "partner":"7vzz" + }, + { + "sim":53.0, + "partner":"7vzu" + }, { "sim":53.0, "partner":"5swi" @@ -727002,15 +729989,15 @@ }, { "sim":52.0, - "partner":"3qna" + "partner":"3qn0" }, { "sim":52.0, - "partner":"3qn0" + "partner":"3qn9" }, { "sim":52.0, - "partner":"3qn9" + "partner":"3qna" }, { "sim":52.0, @@ -727036,14 +730023,6 @@ "sim":52.0, "partner":"5b13" }, - { - "sim":52.0, - "partner":"5scp" - }, - { - "sim":52.0, - "partner":"5scq" - }, { "sim":52.0, "partner":"5scr" @@ -727146,7 +730125,11 @@ }, { "sim":52.0, - "partner":"1x24" + "partner":"5scp" + }, + { + "sim":52.0, + "partner":"5scq" }, { "sim":52.0, @@ -727154,15 +730137,15 @@ }, { "sim":52.0, - "partner":"3rz2" + "partner":"1x24" }, { "sim":52.0, - "partner":"2j8k" + "partner":"3rz2" }, { "sim":52.0, - "partner":"5l9k" + "partner":"2j8k" }, { "sim":52.0, @@ -727180,6 +730163,10 @@ "sim":52.0, "partner":"5lbp" }, + { + "sim":52.0, + "partner":"5l9k" + }, { "sim":52.0, "partner":"4b29" @@ -727190,11 +730177,11 @@ }, { "sim":52.0, - "partner":"1wc6" + "partner":"1wc1" }, { "sim":52.0, - "partner":"1wc1" + "partner":"1wc6" }, { "sim":52.0, @@ -727244,14 +730231,6 @@ "sim":52.0, "partner":"5dtz" }, - { - "sim":52.0, - "partner":"6tlm" - }, - { - "sim":52.0, - "partner":"6tlq" - }, { "sim":52.0, "partner":"6tlt" @@ -727284,6 +730263,14 @@ "sim":52.0, "partner":"6t50" }, + { + "sim":52.0, + "partner":"6tlm" + }, + { + "sim":52.0, + "partner":"6tlq" + }, { "sim":52.0, "partner":"5du0" @@ -727338,39 +730325,39 @@ }, { "sim":52.0, - "partner":"3quo" + "partner":"3qur" }, { "sim":52.0, - "partner":"3qvf" + "partner":"4rnj" }, { "sim":52.0, - "partner":"4rni" + "partner":"3qvh" }, { "sim":52.0, - "partner":"4rnj" + "partner":"3d40" }, { "sim":52.0, - "partner":"3qur" + "partner":"3d41" }, { "sim":52.0, - "partner":"3qvh" + "partner":"3qun" }, { "sim":52.0, - "partner":"3d40" + "partner":"3quo" }, { "sim":52.0, - "partner":"3d41" + "partner":"3qvf" }, { "sim":52.0, - "partner":"3qun" + "partner":"4rni" }, { "sim":52.0, @@ -727398,11 +730385,11 @@ }, { "sim":52.0, - "partner":"5okt" + "partner":"7nzy" }, { "sim":52.0, - "partner":"7nzy" + "partner":"5okt" }, { "sim":52.0, @@ -727554,15 +730541,15 @@ }, { "sim":52.0, - "partner":"5v59" + "partner":"4xem" }, { "sim":52.0, - "partner":"4xem" + "partner":"4xeo" }, { "sim":52.0, - "partner":"4xeo" + "partner":"5v59" }, { "sim":52.0, @@ -727586,11 +730573,11 @@ }, { "sim":52.0, - "partner":"1zdl" + "partner":"1zkq" }, { "sim":52.0, - "partner":"1zkq" + "partner":"1zdl" }, { "sim":52.0, @@ -727598,15 +730585,15 @@ }, { "sim":52.0, - "partner":"5kdn" + "partner":"5kds" }, { "sim":52.0, - "partner":"5kds" + "partner":"5kdu" }, { "sim":52.0, - "partner":"5kdu" + "partner":"5kdn" }, { "sim":52.0, @@ -727682,15 +730669,15 @@ }, { "sim":52.0, - "partner":"6jr8" + "partner":"6jr6" }, { "sim":52.0, - "partner":"6jr6" + "partner":"6jr7" }, { "sim":52.0, - "partner":"6jr7" + "partner":"6jr8" }, { "sim":52.0, @@ -727760,10 +730747,6 @@ "sim":51.0, "partner":"6aq7" }, - { - "sim":51.0, - "partner":"4hmr" - }, { "sim":51.0, "partner":"6t3o" @@ -727776,6 +730759,10 @@ "sim":51.0, "partner":"4hmm" }, + { + "sim":51.0, + "partner":"4hmr" + }, { "sim":51.0, "partner":"6g61" @@ -727806,23 +730793,23 @@ }, { "sim":51.0, - "partner":"3d7j" + "partner":"4nns" }, { "sim":51.0, - "partner":"5y0f" + "partner":"4nnt" }, { "sim":51.0, - "partner":"5y0g" + "partner":"6ljs" }, { "sim":51.0, - "partner":"4nns" + "partner":"6ljt" }, { "sim":51.0, - "partner":"4nnt" + "partner":"6lyw" }, { "sim":51.0, @@ -727830,7 +730817,7 @@ }, { "sim":51.0, - "partner":"6ljs" + "partner":"6lju" }, { "sim":51.0, @@ -727840,18 +730827,6 @@ "sim":51.0, "partner":"5y13" }, - { - "sim":51.0, - "partner":"6ljt" - }, - { - "sim":51.0, - "partner":"6lyw" - }, - { - "sim":51.0, - "partner":"6lju" - }, { "sim":51.0, "partner":"6ljv" @@ -727884,25 +730859,33 @@ "sim":51.0, "partner":"3q6l" }, + { + "sim":51.0, + "partner":"3d7j" + }, { "sim":51.0, "partner":"5y0x" }, { "sim":51.0, - "partner":"6lyx" + "partner":"5y0f" }, { "sim":51.0, - "partner":"2bze" + "partner":"5y0g" }, { "sim":51.0, - "partner":"3wbg" + "partner":"6lyx" }, { "sim":51.0, - "partner":"5hso" + "partner":"2bze" + }, + { + "sim":51.0, + "partner":"3wbg" }, { "sim":51.0, @@ -727922,7 +730905,7 @@ }, { "sim":51.0, - "partner":"3sw1" + "partner":"5hso" }, { "sim":51.0, @@ -727946,11 +730929,11 @@ }, { "sim":51.0, - "partner":"7r4s" + "partner":"6gg9" }, { "sim":51.0, - "partner":"6gg9" + "partner":"7r4s" }, { "sim":51.0, @@ -727958,11 +730941,11 @@ }, { "sim":51.0, - "partner":"5luv" + "partner":"3sw1" }, { "sim":51.0, - "partner":"5aoz" + "partner":"5luv" }, { "sim":51.0, @@ -727972,6 +730955,10 @@ "sim":51.0, "partner":"3ph4" }, + { + "sim":51.0, + "partner":"5aoz" + }, { "sim":51.0, "partner":"4oja" @@ -727982,23 +730969,23 @@ }, { "sim":51.0, - "partner":"7xtl" + "partner":"3l7u" }, { "sim":51.0, - "partner":"3l7u" + "partner":"3l20" }, { "sim":51.0, - "partner":"8oov" + "partner":"5ook" }, { "sim":51.0, - "partner":"3l20" + "partner":"8oov" }, { "sim":51.0, - "partner":"5ook" + "partner":"7xtl" }, { "sim":51.0, @@ -728030,11 +731017,11 @@ }, { "sim":51.0, - "partner":"4nsq" + "partner":"4f07" }, { "sim":51.0, - "partner":"4f07" + "partner":"4nsq" }, { "sim":51.0, @@ -728048,10 +731035,6 @@ "sim":51.0, "partner":"3p6b" }, - { - "sim":51.0, - "partner":"6f3z" - }, { "sim":51.0, "partner":"7q4s" @@ -728066,19 +731049,19 @@ }, { "sim":51.0, - "partner":"2d7j" + "partner":"6f3z" }, { "sim":51.0, - "partner":"6pj9" + "partner":"2d7j" }, { "sim":51.0, - "partner":"6pja" + "partner":"6pjp" }, { "sim":51.0, - "partner":"6pjp" + "partner":"6pjq" }, { "sim":51.0, @@ -728086,11 +731069,11 @@ }, { "sim":51.0, - "partner":"6pjq" + "partner":"6pjr" }, { "sim":51.0, - "partner":"6pjr" + "partner":"6pju" }, { "sim":51.0, @@ -728100,10 +731083,6 @@ "sim":51.0, "partner":"5f5d" }, - { - "sim":51.0, - "partner":"6pju" - }, { "sim":51.0, "partner":"4njp" @@ -728126,15 +731105,19 @@ }, { "sim":51.0, - "partner":"5f5j" + "partner":"6pj5" }, { "sim":51.0, - "partner":"6pj5" + "partner":"6pj7" }, { "sim":51.0, - "partner":"6pj7" + "partner":"5f5j" + }, + { + "sim":51.0, + "partner":"6pj8" }, { "sim":51.0, @@ -728142,7 +731125,11 @@ }, { "sim":51.0, - "partner":"6pj8" + "partner":"6pj9" + }, + { + "sim":51.0, + "partner":"6pja" }, { "sim":51.0, @@ -728182,15 +731169,15 @@ }, { "sim":51.0, - "partner":"6j0l" + "partner":"6j0g" }, { "sim":51.0, - "partner":"6j0g" + "partner":"6j0k" }, { "sim":51.0, - "partner":"6j0k" + "partner":"6j0l" }, { "sim":51.0, @@ -728214,23 +731201,23 @@ }, { "sim":51.0, - "partner":"8vip" + "partner":"8vit" }, { "sim":51.0, - "partner":"8viq" + "partner":"2xx3" }, { "sim":51.0, - "partner":"8vir" + "partner":"8vip" }, { "sim":51.0, - "partner":"8vit" + "partner":"8viq" }, { "sim":51.0, - "partner":"2xx3" + "partner":"8vir" }, { "sim":51.0, @@ -728254,7 +731241,7 @@ }, { "sim":51.0, - "partner":"7o2t" + "partner":"6z17" }, { "sim":51.0, @@ -728262,11 +731249,11 @@ }, { "sim":51.0, - "partner":"6z17" + "partner":"6yz3" }, { "sim":51.0, - "partner":"6yz3" + "partner":"6tpr" }, { "sim":51.0, @@ -728274,15 +731261,15 @@ }, { "sim":51.0, - "partner":"6tpr" + "partner":"6z07" }, { "sim":51.0, - "partner":"6z07" + "partner":"6z5k" }, { "sim":51.0, - "partner":"6z5k" + "partner":"7o2t" }, { "sim":51.0, @@ -728332,10 +731319,6 @@ "sim":51.0, "partner":"1e42" }, - { - "sim":51.0, - "partner":"5h5a" - }, { "sim":51.0, "partner":"3v3d" @@ -728348,6 +731331,10 @@ "sim":51.0, "partner":"5owf" }, + { + "sim":51.0, + "partner":"5h5a" + }, { "sim":51.0, "partner":"2cm1" @@ -728374,11 +731361,11 @@ }, { "sim":51.0, - "partner":"5du6" + "partner":"2ouk" }, { "sim":51.0, - "partner":"2ouk" + "partner":"5du6" }, { "sim":51.0, @@ -728434,23 +731421,23 @@ }, { "sim":51.0, - "partner":"6ub4" + "partner":"6ub2" }, { "sim":51.0, - "partner":"6ub5" + "partner":"6ub3" }, { "sim":51.0, - "partner":"6ub6" + "partner":"6ub4" }, { "sim":51.0, - "partner":"6ub2" + "partner":"6ub5" }, { "sim":51.0, - "partner":"6ub3" + "partner":"6ub6" }, { "sim":51.0, @@ -728490,24 +731477,12 @@ }, { "sim":51.0, - "partner":"5coq" - }, - { - "sim":51.0, - "partner":"5cpb" - }, - { - "sim":51.0, - "partner":"5mtr" + "partner":"4oxk" }, { "sim":51.0, "partner":"5ugt" }, - { - "sim":51.0, - "partner":"4oxk" - }, { "sim":51.0, "partner":"5ugu" @@ -728518,15 +731493,15 @@ }, { "sim":51.0, - "partner":"4oxn" + "partner":"6yuu" }, { "sim":51.0, - "partner":"4oyr" + "partner":"4oxn" }, { "sim":51.0, - "partner":"6yuu" + "partner":"4oyr" }, { "sim":51.0, @@ -728552,10 +731527,22 @@ "sim":51.0, "partner":"5cp8" }, + { + "sim":51.0, + "partner":"5mtr" + }, { "sim":51.0, "partner":"5ugs" }, + { + "sim":51.0, + "partner":"5cpb" + }, + { + "sim":51.0, + "partner":"5coq" + }, { "sim":51.0, "partner":"5zz3" @@ -728586,11 +731573,11 @@ }, { "sim":51.0, - "partner":"1xhl" + "partner":"6p7g" }, { "sim":51.0, - "partner":"6p7g" + "partner":"1xhl" }, { "sim":51.0, @@ -728604,10 +731591,6 @@ "sim":51.0, "partner":"8tms" }, - { - "sim":51.0, - "partner":"3s3h" - }, { "sim":51.0, "partner":"3s3k" @@ -728622,7 +731605,7 @@ }, { "sim":51.0, - "partner":"7xif" + "partner":"3s3h" }, { "sim":51.0, @@ -728638,7 +731621,7 @@ }, { "sim":51.0, - "partner":"3g3d" + "partner":"7xif" }, { "sim":51.0, @@ -728656,6 +731639,10 @@ "sim":51.0, "partner":"4hkp" }, + { + "sim":51.0, + "partner":"3g3d" + }, { "sim":51.0, "partner":"7e4m" @@ -728808,14 +731795,6 @@ "sim":51.0, "partner":"4xzz" }, - { - "sim":51.0, - "partner":"5gg5" - }, - { - "sim":51.0, - "partner":"5xd1" - }, { "sim":51.0, "partner":"5gg6" @@ -728828,6 +731807,10 @@ "sim":51.0, "partner":"5xd3" }, + { + "sim":51.0, + "partner":"6m6y" + }, { "sim":51.0, "partner":"5gg7" @@ -728838,11 +731821,11 @@ }, { "sim":51.0, - "partner":"5xd5" + "partner":"6m65" }, { "sim":51.0, - "partner":"6m6y" + "partner":"5xd5" }, { "sim":51.0, @@ -728852,10 +731835,6 @@ "sim":51.0, "partner":"5hos" }, - { - "sim":51.0, - "partner":"6m65" - }, { "sim":51.0, "partner":"5gg9" @@ -728886,15 +731865,19 @@ }, { "sim":51.0, - "partner":"7r2e" + "partner":"5gg5" }, { "sim":51.0, - "partner":"5v8y" + "partner":"5xd1" }, { "sim":51.0, - "partner":"5jyf" + "partner":"7r2e" + }, + { + "sim":51.0, + "partner":"5v8y" }, { "sim":51.0, @@ -728934,7 +731917,7 @@ }, { "sim":51.0, - "partner":"1vsu" + "partner":"5jyf" }, { "sim":51.0, @@ -728952,6 +731935,10 @@ "sim":51.0, "partner":"5eqn" }, + { + "sim":51.0, + "partner":"1vsu" + }, { "sim":51.0, "partner":"6nor" @@ -729012,10 +731999,6 @@ "sim":51.0, "partner":"4rct" }, - { - "sim":51.0, - "partner":"4m1i" - }, { "sim":51.0, "partner":"4d8f" @@ -729030,12 +732013,16 @@ }, { "sim":51.0, - "partner":"6eow" + "partner":"4m1i" }, { "sim":51.0, "partner":"4lxl" }, + { + "sim":51.0, + "partner":"6eow" + }, { "sim":51.0, "partner":"3wnb" @@ -729088,14 +732075,6 @@ "sim":51.0, "partner":"4ot7" }, - { - "sim":51.0, - "partner":"3pz9" - }, - { - "sim":51.0, - "partner":"6put" - }, { "sim":51.0, "partner":"6puw" @@ -729110,11 +732089,11 @@ }, { "sim":51.0, - "partner":"3dt1" + "partner":"6puy" }, { "sim":51.0, - "partner":"6puy" + "partner":"3dt1" }, { "sim":51.0, @@ -729124,6 +732103,10 @@ "sim":51.0, "partner":"3pzm" }, + { + "sim":51.0, + "partner":"6puz" + }, { "sim":51.0, "partner":"3pzn" @@ -729138,7 +732121,7 @@ }, { "sim":51.0, - "partner":"6puz" + "partner":"6put" }, { "sim":51.0, @@ -729146,7 +732129,7 @@ }, { "sim":51.0, - "partner":"6ojx" + "partner":"3pz9" }, { "sim":51.0, @@ -729178,16 +732161,20 @@ }, { "sim":51.0, - "partner":"7dmb" + "partner":"6ojx" }, { "sim":51.0, - "partner":"8bao" + "partner":"7dmb" }, { "sim":51.0, "partner":"5j8x" }, + { + "sim":51.0, + "partner":"8bao" + }, { "sim":51.0, "partner":"5tzb" @@ -729296,10 +732283,6 @@ "sim":51.0, "partner":"6n85" }, - { - "sim":51.0, - "partner":"4lre" - }, { "sim":51.0, "partner":"4lrf" @@ -729332,6 +732315,10 @@ "sim":51.0, "partner":"4lrd" }, + { + "sim":51.0, + "partner":"4lre" + }, { "sim":51.0, "partner":"2w7y" @@ -729382,27 +732369,27 @@ }, { "sim":51.0, - "partner":"6ry0" + "partner":"6ry5" }, { "sim":51.0, - "partner":"6ry1" + "partner":"6ry6" }, { "sim":51.0, - "partner":"6ry2" + "partner":"6ry7" }, { "sim":51.0, - "partner":"6ry5" + "partner":"6ry0" }, { "sim":51.0, - "partner":"6ry6" + "partner":"6ry1" }, { "sim":51.0, - "partner":"6ry7" + "partner":"6ry2" }, { "sim":51.0, @@ -729430,11 +732417,11 @@ }, { "sim":51.0, - "partner":"8il0" + "partner":"8ila" }, { "sim":51.0, - "partner":"8ila" + "partner":"8il0" }, { "sim":51.0, @@ -729442,15 +732429,15 @@ }, { "sim":51.0, - "partner":"5v1s" + "partner":"5v1t" }, { "sim":51.0, - "partner":"5v1t" + "partner":"8s9i" }, { "sim":51.0, - "partner":"8s9i" + "partner":"8gme" }, { "sim":51.0, @@ -729458,11 +732445,11 @@ }, { "sim":51.0, - "partner":"8gme" + "partner":"5v1q" }, { "sim":51.0, - "partner":"5v1q" + "partner":"5v1s" }, { "sim":51.0, @@ -729546,15 +732533,15 @@ }, { "sim":51.0, - "partner":"4l2h" + "partner":"4epp" }, { "sim":51.0, - "partner":"4epp" + "partner":"4epq" }, { "sim":51.0, - "partner":"4epq" + "partner":"4l2h" }, { "sim":51.0, @@ -729572,10 +732559,6 @@ "sim":51.0, "partner":"5t3b" }, - { - "sim":51.0, - "partner":"6rk2" - }, { "sim":51.0, "partner":"6rjo" @@ -729590,19 +732573,19 @@ }, { "sim":51.0, - "partner":"6jmw" + "partner":"6rk2" }, { "sim":51.0, - "partner":"6jzs" + "partner":"6jmw" }, { "sim":51.0, - "partner":"5l77" + "partner":"6jzs" }, { "sim":51.0, - "partner":"6pt4" + "partner":"5l77" }, { "sim":51.0, @@ -729616,6 +732599,10 @@ "sim":51.0, "partner":"6ptk" }, + { + "sim":51.0, + "partner":"6pt4" + }, { "sim":51.0, "partner":"6rim" @@ -729770,27 +732757,27 @@ }, { "sim":51.0, - "partner":"4ids" + "partner":"4lem" }, { "sim":51.0, - "partner":"4jdc" + "partner":"4idm" }, { "sim":51.0, - "partner":"4lem" + "partner":"4ns3" }, { "sim":51.0, - "partner":"4idm" + "partner":"4ihi" }, { "sim":51.0, - "partner":"4ns3" + "partner":"4ids" }, { "sim":51.0, - "partner":"4ihi" + "partner":"4jdc" }, { "sim":51.0, @@ -729818,15 +732805,15 @@ }, { "sim":51.0, - "partner":"5tsh" + "partner":"6olj" }, { "sim":51.0, - "partner":"6olj" + "partner":"5tsg" }, { "sim":51.0, - "partner":"5tsg" + "partner":"5tsh" }, { "sim":51.0, @@ -729842,11 +732829,11 @@ }, { "sim":51.0, - "partner":"7jwf" + "partner":"7jw4" }, { "sim":51.0, - "partner":"7jw4" + "partner":"7jwf" }, { "sim":51.0, @@ -729866,15 +732853,15 @@ }, { "sim":51.0, - "partner":"6k8s" + "partner":"6k8t" }, { "sim":51.0, - "partner":"6k8t" + "partner":"6k8u" }, { "sim":51.0, - "partner":"6k8u" + "partner":"6k8s" }, { "sim":51.0, @@ -729892,10 +732879,6 @@ "sim":51.0, "partner":"5x7h" }, - { - "sim":51.0, - "partner":"7wlg" - }, { "sim":51.0, "partner":"7wj9" @@ -729926,23 +732909,19 @@ }, { "sim":51.0, - "partner":"7p1g" - }, - { - "sim":51.0, - "partner":"3slk" + "partner":"7wlg" }, { "sim":51.0, - "partner":"7p1h" + "partner":"7p1g" }, { "sim":51.0, - "partner":"4j3t" + "partner":"3slk" }, { "sim":51.0, - "partner":"4j3u" + "partner":"7p1h" }, { "sim":51.0, @@ -729962,7 +732941,11 @@ }, { "sim":51.0, - "partner":"5y1h" + "partner":"4j3t" + }, + { + "sim":51.0, + "partner":"4j3u" }, { "sim":51.0, @@ -730008,6 +732991,10 @@ "sim":51.0, "partner":"5y3i" }, + { + "sim":51.0, + "partner":"5y1h" + }, { "sim":51.0, "partner":"7s6b" @@ -730166,11 +733153,11 @@ }, { "sim":50.0, - "partner":"6tq2" + "partner":"6tq1" }, { "sim":50.0, - "partner":"6tq1" + "partner":"6tq2" }, { "sim":50.0, @@ -730204,10 +733191,6 @@ "sim":50.0, "partner":"6okn" }, - { - "sim":50.0, - "partner":"3v57" - }, { "sim":50.0, "partner":"7y1a" @@ -730224,6 +733207,10 @@ "sim":50.0, "partner":"8b4n" }, + { + "sim":50.0, + "partner":"3v57" + }, { "sim":50.0, "partner":"4yxl" @@ -730234,11 +733221,11 @@ }, { "sim":50.0, - "partner":"2wja" + "partner":"7a6p" }, { "sim":50.0, - "partner":"7a6p" + "partner":"2wja" }, { "sim":50.0, @@ -730246,15 +733233,15 @@ }, { "sim":50.0, - "partner":"7r5n" + "partner":"4ip3" }, { "sim":50.0, - "partner":"4ip3" + "partner":"7r5n" }, { "sim":50.0, - "partner":"5edd" + "partner":"8p8o" }, { "sim":50.0, @@ -730282,15 +733269,15 @@ }, { "sim":50.0, - "partner":"8p8o" + "partner":"1sm8" }, { "sim":50.0, - "partner":"1sm8" + "partner":"3hza" }, { "sim":50.0, - "partner":"3hza" + "partner":"5edd" }, { "sim":50.0, @@ -730334,15 +733321,15 @@ }, { "sim":50.0, - "partner":"4gzc" + "partner":"4gzd" }, { "sim":50.0, - "partner":"4gzd" + "partner":"7eh9" }, { "sim":50.0, - "partner":"7eh9" + "partner":"4gzc" }, { "sim":50.0, @@ -730436,10 +733423,6 @@ "sim":50.0, "partner":"2gcp" }, - { - "sim":50.0, - "partner":"3th5" - }, { "sim":50.0, "partner":"4gzl" @@ -730458,7 +733441,7 @@ }, { "sim":50.0, - "partner":"3l1u" + "partner":"3th5" }, { "sim":50.0, @@ -730480,6 +733463,10 @@ "sim":50.0, "partner":"3esr" }, + { + "sim":50.0, + "partner":"3l1u" + }, { "sim":50.0, "partner":"2l22" @@ -730494,11 +733481,11 @@ }, { "sim":50.0, - "partner":"3umf" + "partner":"7fe5" }, { "sim":50.0, - "partner":"7fe5" + "partner":"3umf" }, { "sim":50.0, @@ -730514,15 +733501,15 @@ }, { "sim":50.0, - "partner":"6a98" + "partner":"6a99" }, { "sim":50.0, - "partner":"6a99" + "partner":"6a9f" }, { "sim":50.0, - "partner":"6a9f" + "partner":"6a98" }, { "sim":50.0, @@ -730554,31 +733541,31 @@ }, { "sim":50.0, - "partner":"7mnq" + "partner":"7mns" }, { "sim":50.0, - "partner":"7mnr" + "partner":"7mnt" }, { "sim":50.0, - "partner":"7mns" + "partner":"4irb" }, { "sim":50.0, - "partner":"4irb" + "partner":"7mnu" }, { "sim":50.0, - "partner":"7mnt" + "partner":"7mnv" }, { "sim":50.0, - "partner":"7mnu" + "partner":"7mnq" }, { "sim":50.0, - "partner":"7mnv" + "partner":"7mnr" }, { "sim":50.0, @@ -730624,10 +733611,6 @@ "sim":50.0, "partner":"4zb1" }, - { - "sim":50.0, - "partner":"4da6" - }, { "sim":50.0, "partner":"4da7" @@ -730682,15 +733665,19 @@ }, { "sim":50.0, - "partner":"2dps" + "partner":"4da6" }, { "sim":50.0, - "partner":"2dpt" + "partner":"8bat" }, { "sim":50.0, - "partner":"8bat" + "partner":"2dps" + }, + { + "sim":50.0, + "partner":"2dpt" }, { "sim":50.0, @@ -730752,10 +733739,6 @@ "sim":50.0, "partner":"5m09" }, - { - "sim":50.0, - "partner":"3dbp" - }, { "sim":50.0, "partner":"3mo7" @@ -730778,23 +733761,27 @@ }, { "sim":50.0, - "partner":"6t2p" + "partner":"3dbp" }, { "sim":50.0, - "partner":"2wk1" + "partner":"6akv" }, { "sim":50.0, - "partner":"6t2q" + "partner":"6t2o" }, { "sim":50.0, - "partner":"6akv" + "partner":"6t2p" }, { "sim":50.0, - "partner":"6t2o" + "partner":"6t2q" + }, + { + "sim":50.0, + "partner":"2wk1" }, { "sim":50.0, @@ -730858,19 +733845,19 @@ }, { "sim":50.0, - "partner":"5lsg" + "partner":"6t9c" }, { "sim":50.0, - "partner":"6t9c" + "partner":"5lsg" }, { "sim":50.0, - "partner":"5l45" + "partner":"6qj5" }, { "sim":50.0, - "partner":"6qj5" + "partner":"5l45" }, { "sim":50.0, @@ -730886,11 +733873,11 @@ }, { "sim":50.0, - "partner":"6y5x" + "partner":"6y5y" }, { "sim":50.0, - "partner":"6y5y" + "partner":"6y5x" }, { "sim":50.0, @@ -730912,10 +733899,6 @@ "sim":50.0, "partner":"2qj3" }, - { - "sim":50.0, - "partner":"3aio" - }, { "sim":50.0, "partner":"3aik" @@ -730936,6 +733919,10 @@ "sim":50.0, "partner":"3ain" }, + { + "sim":50.0, + "partner":"3aio" + }, { "sim":50.0, "partner":"6t2n" @@ -730946,19 +733933,19 @@ }, { "sim":50.0, - "partner":"3tmc" + "partner":"3tm8" }, { "sim":50.0, - "partner":"3tmd" + "partner":"3tmb" }, { "sim":50.0, - "partner":"3tm8" + "partner":"3tmc" }, { "sim":50.0, - "partner":"3tmb" + "partner":"3tmd" }, { "sim":50.0, @@ -730968,10 +733955,6 @@ "sim":50.0, "partner":"3rlh" }, - { - "sim":50.0, - "partner":"2pzm" - }, { "sim":50.0, "partner":"2qry" @@ -730986,12 +733969,16 @@ }, { "sim":50.0, - "partner":"6lcn" + "partner":"2pzm" }, { "sim":50.0, "partner":"7x1l" }, + { + "sim":50.0, + "partner":"6lcn" + }, { "sim":50.0, "partner":"7f8d" @@ -731022,23 +734009,23 @@ }, { "sim":50.0, - "partner":"6q4x" + "partner":"6q4z" }, { "sim":50.0, - "partner":"6q4y" + "partner":"5zci" }, { "sim":50.0, - "partner":"6q4z" + "partner":"5zcm" }, { "sim":50.0, - "partner":"5zci" + "partner":"6q4x" }, { "sim":50.0, - "partner":"5zcm" + "partner":"6q4y" }, { "sim":50.0, @@ -731104,18 +734091,6 @@ "sim":50.0, "partner":"4ilk" }, - { - "sim":50.0, - "partner":"4m25" - }, - { - "sim":50.0, - "partner":"4m2i" - }, - { - "sim":50.0, - "partner":"4ne0" - }, { "sim":50.0, "partner":"4m26" @@ -731152,6 +734127,18 @@ "sim":50.0, "partner":"4m2g" }, + { + "sim":50.0, + "partner":"4m25" + }, + { + "sim":50.0, + "partner":"4m2i" + }, + { + "sim":50.0, + "partner":"4ne0" + }, { "sim":50.0, "partner":"7us5" @@ -731222,31 +734209,31 @@ }, { "sim":50.0, - "partner":"6zgp" + "partner":"6y9d" }, { "sim":50.0, - "partner":"6y8j" + "partner":"6zgp" }, { "sim":50.0, - "partner":"6y9c" + "partner":"2qap" }, { "sim":50.0, - "partner":"6y9d" + "partner":"6y8s" }, { "sim":50.0, - "partner":"2qap" + "partner":"2qdg" }, { "sim":50.0, - "partner":"6y8s" + "partner":"6y8j" }, { "sim":50.0, - "partner":"2qdg" + "partner":"6y9c" }, { "sim":50.0, @@ -731322,11 +734309,7 @@ }, { "sim":50.0, - "partner":"5dvi" - }, - { - "sim":50.0, - "partner":"5xw2" + "partner":"4e2p" }, { "sim":50.0, @@ -731334,11 +734317,11 @@ }, { "sim":50.0, - "partner":"4e2p" + "partner":"3ssm" }, { "sim":50.0, - "partner":"3ssm" + "partner":"8d19" }, { "sim":50.0, @@ -731346,16 +734329,12 @@ }, { "sim":50.0, - "partner":"8d19" + "partner":"8czk" }, { "sim":50.0, "partner":"3sso" }, - { - "sim":50.0, - "partner":"8czk" - }, { "sim":50.0, "partner":"8czl" @@ -731368,6 +734347,14 @@ "sim":50.0, "partner":"5dvf" }, + { + "sim":50.0, + "partner":"5dvi" + }, + { + "sim":50.0, + "partner":"5xw2" + }, { "sim":50.0, "partner":"3zu2" @@ -731406,15 +734393,15 @@ }, { "sim":50.0, - "partner":"5z8a" + "partner":"5z8k" }, { "sim":50.0, - "partner":"5z8k" + "partner":"5z83" }, { "sim":50.0, - "partner":"5z83" + "partner":"5z8a" }, { "sim":50.0, @@ -731508,10 +734495,6 @@ "sim":50.0, "partner":"6qps" }, - { - "sim":50.0, - "partner":"2wc4" - }, { "sim":50.0, "partner":"1oif" @@ -731624,6 +734607,10 @@ "sim":50.0, "partner":"1uz1" }, + { + "sim":50.0, + "partner":"2wc4" + }, { "sim":50.0, "partner":"6j0u" @@ -731712,10 +734699,6 @@ "sim":50.0, "partner":"4ife" }, - { - "sim":50.0, - "partner":"5uno" - }, { "sim":50.0, "partner":"7m7c" @@ -731734,11 +734717,11 @@ }, { "sim":50.0, - "partner":"4l6w" + "partner":"5uno" }, { "sim":50.0, - "partner":"6x0h" + "partner":"4l6w" }, { "sim":50.0, @@ -731748,6 +734731,10 @@ "sim":50.0, "partner":"6x0k" }, + { + "sim":50.0, + "partner":"6x0h" + }, { "sim":50.0, "partner":"6pop" @@ -731770,11 +734757,11 @@ }, { "sim":50.0, - "partner":"7an1" + "partner":"7oqd" }, { "sim":50.0, - "partner":"7oqd" + "partner":"7an1" }, { "sim":50.0, @@ -731826,15 +734813,15 @@ }, { "sim":50.0, - "partner":"7mdl" + "partner":"8g9z" }, { "sim":50.0, - "partner":"8g9z" + "partner":"7l1t" }, { "sim":50.0, - "partner":"7l1t" + "partner":"7mdl" }, { "sim":50.0, @@ -731858,47 +734845,47 @@ }, { "sim":50.0, - "partner":"8aq3" + "partner":"7aci" }, { "sim":50.0, - "partner":"8aq4" + "partner":"8b0k" }, { "sim":50.0, - "partner":"7aci" + "partner":"8b0l" }, { "sim":50.0, - "partner":"8b0k" + "partner":"8b0m" }, { "sim":50.0, - "partner":"5n6h" + "partner":"8b0n" }, { "sim":50.0, - "partner":"8b0l" + "partner":"5n6h" }, { "sim":50.0, - "partner":"8b0m" + "partner":"8b0o" }, { "sim":50.0, - "partner":"8b0n" + "partner":"8b0p" }, { "sim":50.0, - "partner":"8b0o" + "partner":"5n6l" }, { "sim":50.0, - "partner":"8b0p" + "partner":"8aq3" }, { "sim":50.0, - "partner":"5n6l" + "partner":"8aq4" }, { "sim":50.0, @@ -732030,15 +735017,15 @@ }, { "sim":50.0, - "partner":"7w1c" + "partner":"7w1d" }, { "sim":50.0, - "partner":"7w1d" + "partner":"7w1e" }, { "sim":50.0, - "partner":"7w1e" + "partner":"7w1c" }, { "sim":50.0, @@ -732110,15 +735097,15 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"6edz" }, { "sim":50.0, - "partner":"6edz" + "partner":"6ee1" }, { "sim":50.0, - "partner":"6ee1" + "partner":"6edw" }, { "sim":50.0, @@ -732235,81 +735222,81 @@ "subtitle":"Hyper-thermostable ancestral l-amino acid oxidase 2 (htanclaao2)", "tags":[ "l-amino acid oxidases", - "ancestral sequence reconstruction", + "oxidoreductase", "fad-dependent", - "oxidoreductase" + "ancestral sequence reconstruction" ], "keywords":[ - "stability", - "variant", - "derivatives", - "toward", + "designed", + "form", + "property", + "cat", + "amines", + "enables", "analysis", - "k", - "obtained", - "original", - "oxidase", - "excellent", - "demonstrated", - "exhibits", - "thermostability", - "larger", + "designing", + "octameric", + "shows", + "htanclaao2", + "compared", + "scale", + "value", "values", - "enables", - "revealing", - "study", - "\u00e5", - "four", - "screening", + "variants", + "therapeutics", "feature", - "acid", - "crystallography", - "octameric", - "peptide", + "starting", + "exhibiting", + "reconstruction", + "oxidase", + "\u00e5", + "precursors", "enzymatic", - "enzyme", - "acids", - "designed", - "cat", - "variants", + "applies", + "structure", + "thermostability", + "acid", + "derivatives", + "variant", + "provide", + "determined", + "revealing", + "oxidases", + "exhibits", "point", + "various", + "crystallography", + "aas", + "study", + "preparative", + "stability", + "given", "would", - "exhibiting", - "value", - "provide", "ancestral", "towards", + "high", + "obtained", + "increase", + "synthesizing", "activity", + "sequence", + "enzyme", + "demonstrated", + "larger", + "acids", + "excellent", + "original", + "toward", "crystal", - "amines", - "determined", - "preparative", + "k", + "four", + "screening", + "like", + "properties", + "peptide", "production", - "reconstruction", - "therapeutics", - "scale", - "given", - "htanclaao2", - "precursors", - "designing", - "high", - "structure", - "sequence", - "w220a", - "synthesizing", - "oxidases", - "various", - "property", - "increase", - "form", - "shows", - "compared", "novel", - "starting", - "applies", - "like", - "aas", - "properties" + "w220a" ], "release_date":"2023-10-04", "publication":"\"Structural and functional analysis of hyper-thermostable ancestral L-amino acid oxidase that can convert Trp derivatives to D-forms by chemoenzymatic reaction\", Commun Chem, 6, 200-200", @@ -732342,7 +735329,7 @@ "seq_thr_sim_designed":[ { "sim":166.0, - "partner":"7x7i" + "partner":"7x7k" }, { "sim":166.0, @@ -732350,7 +735337,7 @@ }, { "sim":166.0, - "partner":"7x7k" + "partner":"7x7i" } ], "seq_thr_sim_natural":[ @@ -732368,19 +735355,19 @@ }, { "sim":164.0, - "partner":"7c4k" + "partner":"7c4m" }, { "sim":164.0, - "partner":"7c4l" + "partner":"7c4n" }, { "sim":164.0, - "partner":"7c4m" + "partner":"7c4k" }, { "sim":164.0, - "partner":"7c4n" + "partner":"7c4l" }, { "sim":154.0, @@ -732400,19 +735387,19 @@ }, { "sim":51.0, - "partner":"1tdk" + "partner":"1tdo" }, { "sim":51.0, - "partner":"1tdn" + "partner":"1reo" }, { "sim":51.0, - "partner":"1tdo" + "partner":"1tdk" }, { "sim":51.0, - "partner":"1reo" + "partner":"1tdn" }, { "sim":50.0, @@ -732431,7 +735418,7 @@ ], "seq_max_sim_designed":{ "sim":166.0, - "partner":"7x7i" + "partner":"7x7k" }, "seq_max_sim_natural":{ "sim":258.0, @@ -732466,6 +735453,46 @@ { "forename":"X.X.", "surname":"Zhu" + }, + { + "forename":"W.Q.", + "surname":"Zheng" + }, + { + "forename":"Z.W.", + "surname":"Xia" + }, + { + "forename":"X.R.", + "surname":"Chen" + }, + { + "forename":"T.", + "surname":"Jin" + }, + { + "forename":"X.W.", + "surname":"Ding" + }, + { + "forename":"F.F.", + "surname":"Chen" + }, + { + "forename":"Q.", + "surname":"Chen" + }, + { + "forename":"J.H.", + "surname":"Xu" + }, + { + "forename":"X.D.", + "surname":"Kong" + }, + { + "forename":"G.W.", + "surname":"Zheng" } ], "classification":"unknown", @@ -732475,111 +735502,111 @@ "classification_suggested_reason":[ ], - "subtitle":"Ancestal imine reductase", + "subtitle":"Ancestral imine reductase n559", "tags":[ + "de novo protein", "ancestral protein", - "nadph-dependent oxidoreductase", - "de novo protein" + "nadph-dependent oxidoreductase" ], "keywords":[ - "darwinian", - "analysis", - "evolution", - "recapitulating", - "change", - "studies", - "herein", - "combined", - "crystallography", - "dearth", - "stepwise", - "mutations", - "support", + "molecular", + "role", + "collectively", "stereocomplementarity", - "trajectory", - "findings", - "discover", - "circumventing", + "six", "members", + "historical", "identifying", - "biocatalytic", - "however", + "inversion", "prevalent", - "cryptic", + "stepwise", "power", - "excellent", + "recapitulating", + "asymmetric", + "reductases", + "shows", + "however", + "reactions", + "biological", + "perspective", + "biocatalytic", + "family", "possesses", - "historical", - "ancestors", - "stereoselectivity", + "trajectory", + "asr", + "cryptic", + "library", + "functions", + "premise", + "combined", "process", + "capable", + "ancestral", "enzymes", - "family", - "ireds", "enzyme", - "remains", - "ancestral", - "evolutionary", - "reductases", + "evolution", + "behind", "reconstruct", - "empirical", - "premise", "construct", - "asr", - "shows", - "role", - "coevolution", - "plays", - "molecular", "regulate", - "inversion", - "trace", - "perspective", - "asymmetric", - "behind", - "screening", - "reactions", - "active", - "functions", - "landscape", - "six", - "fitness", - "biochemistry", "pervasive", "vital", - "biological", "property", - "extant", - "panel", - "library", - "one", + "mutagenesis", + "pocket", + "active", "reshape", - "emphasize", - "epistasis", + "extant", "imine", - "reveal", - "capable", - "central", + "stereoselectivity", + "empirical", "addition", + "ireds", + "biochemistry", + "ancestors", + "excellent", + "landscape", "mechanism", - "investigating", - "collectively", - "stereocomplementary", + "screening", + "darwinian", + "evolutionary", + "reveal", + "central", + "analysis", + "dearth", + "one", + "panel", + "mutations", "regulatory", + "epistasis", + "remains", + "emphasize", + "discover", + "herein", + "findings", + "circumventing", + "crystallography", + "plays", + "coevolution", "investigation", - "pocket", - "mutagenesis" + "change", + "support", + "trace", + "stereocomplementary", + "studies", + "investigating", + "fitness" ], "release_date":"2023-08-09", - "publication":"To be published", + "publication":"\"Evolutionary insights into the stereoselectivity of imine reductases based on ancestral sequence reconstruction\", Nat Commun, 15, 10330-10330", "publication_ref":{ - "DOI":"", - "PubMed":"", + "DOI":"10.1038\/s41467-024-54613-3", + "PubMed":"39609402", "CSD":"", - "ISSN":"", + "ISSN":"2041-1723", "ASTM":"" }, - "publication_country":"", + "publication_country":"UK", "abstract":"The stereoselectivity of enzymes plays a central role in asymmetric biocatalytic reactions, but there remains a dearth of evolution-driven biochemistry studies investigating the evolutionary trajectory of this vital property. Imine reductases (IREDs) are one such enzyme that possesses excellent stereoselectivity, and stereocomplementary members are pervasive in the family. However, the regulatory mechanism behind stereocomplementarity remains cryptic. Herein, we reconstruct a panel of active ancestral IREDs and trace the evolution of stereoselectivity from ancestors to extant IREDs. Combined with coevolution analysis, we reveal six historical mutations capable of recapitulating stereoselectivity evolution. An investigation of the mechanism with X-ray crystallography shows that they collectively reshape the substrate-binding pocket to regulate stereoselectivity inversion. In addition, we construct an empirical fitness landscape and discover that epistasis is prevalent in stereoselectivity evolution. Our findings emphasize the power of ASR in circumventing the time-consuming large-scale mutagenesis library screening for identifying mutations that change functions and support a Darwinian premise from a molecular perspective that the evolution of biological functions is a stepwise process.", "crystal_structure":{ "length_a":"71.676", @@ -732769,6 +735796,10 @@ "sim":181.0, "partner":"8a3x" }, + { + "sim":171.0, + "partner":"8y12" + }, { "sim":138.0, "partner":"7a3w" @@ -732789,10 +735820,6 @@ "sim":64.0, "partner":"3doj" }, - { - "sim":63.0, - "partner":"3ws7" - }, { "sim":63.0, "partner":"5xvh" @@ -732805,6 +735832,10 @@ "sim":63.0, "partner":"3w6z" }, + { + "sim":63.0, + "partner":"3ws7" + }, { "sim":60.0, "partner":"4gbj" @@ -732908,75 +735939,75 @@ ], "subtitle":"De novo design cavitated protein without predefined topology", "tags":[ - "cavitated protein", "de novo protein", + "cavitated protein", "de novo design" ], "keywords":[ - "great", + "designed", + "designing", + "introducing", + "naturally", + "design", + "sampling", + "energy", + "cavities", + "backbones", + "521", + "one", + "indicate", + "tailored", "diverse", - "statistical", + "methods", + "structures", + "hold", + "de", + "efforts", + "rmsds", + "agreement", + "dimer", + "experimentally", + "side", + "based", + "potential", + "\u00e5", + "tested", "without", - "architectures", - "restraints", - "designs", - "deviations", + "c\u03b1", "predefined", - "arrangement", - "tested", - "tailored", + "atoms", + "deviations", + "within", + "partial", + "results", + "determined", + "great", + "driven", + "closely", + "model", + "protein", "network", - "one", + "architectures", + "function", "proteins", - "results", + "neural", "5816", - "de", - "rmsds", + "backbone", + "occurring", "novo", - "efforts", - "driven", - "\u00e5", - "hold", - "designed", - "atoms", - "10", + "agrees", "requires", - "closely", - "dimer", - "agreement", - "521", + "arrangement", + "forms", + "contain", "two", - "experimentally", "crystal", - "methods", - "occurring", - "determined", - "potential", - "based", - "design", - "sampling", - "model", - "partial", - "structures", - "protein", - "naturally", + "designs", "scuba", + "10", + "restraints", "previous", - "backbone", - "agrees", - "designing", - "c\u03b1", - "neural", - "cavities", - "function", - "indicate", - "energy", - "within", - "introducing", - "side", - "backbones", - "forms", - "contain" + "statistical" ], "release_date":"2023-06-28", "publication":"\"De novo design of cavity-containing proteins with a backbone-centered neural network energy function\", Structure, 32, 424-432.e4", @@ -733013,11 +736044,11 @@ }, { "sim":90.0, - "partner":"8j1x" + "partner":"8j98" }, { "sim":90.0, - "partner":"8j98" + "partner":"8j1x" }, { "sim":90.0, @@ -733029,11 +736060,11 @@ }, { "sim":57.0, - "partner":"8v2w" + "partner":"8v09" }, { "sim":57.0, - "partner":"8v09" + "partner":"8v2w" }, { "sim":55.0, @@ -733041,15 +736072,15 @@ }, { "sim":55.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":55.0, - "partner":"8w05" + "partner":"8w06" }, { "sim":54.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":54.0, @@ -733057,7 +736088,7 @@ }, { "sim":54.0, - "partner":"8w08" + "partner":"8v0a" }, { "sim":53.0, @@ -733117,10 +736148,6 @@ "sim":76.0, "partner":"5gv1" }, - { - "sim":76.0, - "partner":"7dw8" - }, { "sim":76.0, "partner":"7dwa" @@ -733139,12 +736166,16 @@ }, { "sim":76.0, - "partner":"7y0k" + "partner":"7dw8" }, { "sim":76.0, "partner":"7xwu" }, + { + "sim":76.0, + "partner":"7y0k" + }, { "sim":76.0, "partner":"7dkg" @@ -733189,18 +736220,6 @@ "sim":74.0, "partner":"3l9f" }, - { - "sim":74.0, - "partner":"7ex2" - }, - { - "sim":74.0, - "partner":"7ex3" - }, - { - "sim":74.0, - "partner":"7ex4" - }, { "sim":74.0, "partner":"7ex6" @@ -733249,6 +736268,18 @@ "sim":74.0, "partner":"7ex1" }, + { + "sim":74.0, + "partner":"7ex2" + }, + { + "sim":74.0, + "partner":"7ex3" + }, + { + "sim":74.0, + "partner":"7ex4" + }, { "sim":74.0, "partner":"3l87" @@ -733363,11 +736394,11 @@ }, { "sim":73.0, - "partner":"3la8" + "partner":"3lba" }, { "sim":73.0, - "partner":"3lba" + "partner":"3la8" }, { "sim":73.0, @@ -733417,10 +736448,6 @@ "sim":73.0, "partner":"5c1t" }, - { - "sim":73.0, - "partner":"6jtl" - }, { "sim":73.0, "partner":"6jti" @@ -733433,6 +736460,10 @@ "sim":73.0, "partner":"6jtk" }, + { + "sim":73.0, + "partner":"6jtl" + }, { "sim":73.0, "partner":"3psp" @@ -733477,10 +736508,6 @@ "sim":72.0, "partner":"2kxn" }, - { - "sim":72.0, - "partner":"3ul6" - }, { "sim":72.0, "partner":"2kg1" @@ -733495,16 +736522,20 @@ }, { "sim":72.0, - "partner":"4qpj" + "partner":"3ul6" }, { "sim":72.0, - "partner":"6isk" + "partner":"4qpj" }, { "sim":72.0, "partner":"6isl" }, + { + "sim":72.0, + "partner":"6isk" + }, { "sim":72.0, "partner":"4egs" @@ -733565,10 +736596,6 @@ "sim":72.0, "partner":"3wg8" }, - { - "sim":72.0, - "partner":"2uxx" - }, { "sim":72.0, "partner":"2iw5" @@ -733581,6 +736608,10 @@ "sim":72.0, "partner":"4kum" }, + { + "sim":72.0, + "partner":"2uxx" + }, { "sim":72.0, "partner":"7vxo" @@ -733707,27 +736738,27 @@ }, { "sim":72.0, - "partner":"6alm" + "partner":"6alo" }, { "sim":72.0, - "partner":"6aln" + "partner":"6alp" }, { "sim":72.0, - "partner":"6alo" + "partner":"6alq" }, { "sim":72.0, - "partner":"6alp" + "partner":"6alr" }, { "sim":72.0, - "partner":"6alq" + "partner":"6alm" }, { "sim":72.0, - "partner":"6alr" + "partner":"6aln" }, { "sim":72.0, @@ -733737,10 +736768,6 @@ "sim":72.0, "partner":"4irn" }, - { - "sim":72.0, - "partner":"3pln" - }, { "sim":72.0, "partner":"3phl" @@ -733755,15 +736782,15 @@ }, { "sim":72.0, - "partner":"3pid" + "partner":"3pln" }, { "sim":72.0, - "partner":"5ex6" + "partner":"3pid" }, { "sim":72.0, - "partner":"3nc3" + "partner":"5ex6" }, { "sim":72.0, @@ -733777,6 +736804,10 @@ "sim":72.0, "partner":"3nc7" }, + { + "sim":72.0, + "partner":"3nc3" + }, { "sim":72.0, "partner":"4lyp" @@ -733799,11 +736830,11 @@ }, { "sim":72.0, - "partner":"4nxl" + "partner":"4jek" }, { "sim":72.0, - "partner":"4jek" + "partner":"4nxl" }, { "sim":72.0, @@ -733831,28 +736862,20 @@ }, { "sim":72.0, - "partner":"6unz" - }, - { - "sim":72.0, - "partner":"6uoj" + "partner":"6msn" }, { "sim":72.0, - "partner":"6upo" + "partner":"6unz" }, { "sim":72.0, - "partner":"6msn" + "partner":"6uq8" }, { "sim":72.0, "partner":"5l2r" }, - { - "sim":72.0, - "partner":"6uq8" - }, { "sim":72.0, "partner":"6uo0" @@ -733889,6 +736912,26 @@ "sim":72.0, "partner":"6up9" }, + { + "sim":72.0, + "partner":"6uoj" + }, + { + "sim":72.0, + "partner":"6upo" + }, + { + "sim":72.0, + "partner":"8vjq" + }, + { + "sim":72.0, + "partner":"8vix" + }, + { + "sim":72.0, + "partner":"8vh0" + }, { "sim":72.0, "partner":"4zci" @@ -733979,11 +737022,11 @@ }, { "sim":71.0, - "partner":"6mwy" + "partner":"6myl" }, { "sim":71.0, - "partner":"6myl" + "partner":"6mwy" }, { "sim":71.0, @@ -734003,11 +737046,11 @@ }, { "sim":71.0, - "partner":"5feu" + "partner":"6y4d" }, { "sim":71.0, - "partner":"6y4d" + "partner":"5feu" }, { "sim":71.0, @@ -734231,11 +737274,11 @@ }, { "sim":70.0, - "partner":"5nbt" + "partner":"6gzc" }, { "sim":70.0, - "partner":"6gzc" + "partner":"5nbt" }, { "sim":70.0, @@ -734265,10 +737308,6 @@ "sim":70.0, "partner":"4nod" }, - { - "sim":70.0, - "partner":"5nbh" - }, { "sim":70.0, "partner":"5n8d" @@ -734281,6 +737320,10 @@ "sim":70.0, "partner":"5n83" }, + { + "sim":70.0, + "partner":"5nbh" + }, { "sim":70.0, "partner":"4qpk" @@ -734309,10 +737352,6 @@ "sim":70.0, "partner":"5ywt" }, - { - "sim":70.0, - "partner":"7eny" - }, { "sim":70.0, "partner":"8hp5" @@ -734327,12 +737366,16 @@ }, { "sim":70.0, - "partner":"6pei" + "partner":"7eny" }, { "sim":70.0, "partner":"6pej" }, + { + "sim":70.0, + "partner":"6pei" + }, { "sim":70.0, "partner":"7w16" @@ -734369,10 +737412,6 @@ "sim":70.0, "partner":"6dj6" }, - { - "sim":70.0, - "partner":"5yoi" - }, { "sim":70.0, "partner":"5ypj" @@ -734389,6 +737428,10 @@ "sim":70.0, "partner":"5yoh" }, + { + "sim":70.0, + "partner":"5yoi" + }, { "sim":70.0, "partner":"3pl5" @@ -734431,15 +737474,11 @@ }, { "sim":70.0, - "partner":"7cm8" - }, - { - "sim":70.0, - "partner":"7djq" + "partner":"7c35" }, { "sim":70.0, - "partner":"7c35" + "partner":"7ewo" }, { "sim":70.0, @@ -734455,7 +737494,7 @@ }, { "sim":70.0, - "partner":"7ewo" + "partner":"7cm8" }, { "sim":70.0, @@ -734463,11 +737502,11 @@ }, { "sim":70.0, - "partner":"7cd5" + "partner":"7djq" }, { "sim":70.0, - "partner":"3tro" + "partner":"7cd5" }, { "sim":70.0, @@ -734477,6 +737516,10 @@ "sim":70.0, "partner":"7myd" }, + { + "sim":70.0, + "partner":"3tro" + }, { "sim":70.0, "partner":"3tn3" @@ -734519,15 +737562,15 @@ }, { "sim":70.0, - "partner":"8uen" + "partner":"8uro" }, { "sim":70.0, - "partner":"8ura" + "partner":"8uen" }, { "sim":70.0, - "partner":"8uro" + "partner":"8ura" }, { "sim":70.0, @@ -734539,23 +737582,23 @@ }, { "sim":70.0, - "partner":"7ffg" + "partner":"7ffi" }, { "sim":70.0, - "partner":"7ffh" + "partner":"7ffa" }, { "sim":70.0, - "partner":"7ffi" + "partner":"7ffc" }, { "sim":70.0, - "partner":"7ffa" + "partner":"7ffg" }, { "sim":70.0, - "partner":"7ffc" + "partner":"7ffh" }, { "sim":70.0, @@ -734611,11 +737654,11 @@ }, { "sim":70.0, - "partner":"3l7r" + "partner":"3t0c" }, { "sim":70.0, - "partner":"3t0c" + "partner":"3l7r" }, { "sim":70.0, @@ -734657,21 +737700,17 @@ "sim":69.0, "partner":"7cys" }, - { - "sim":69.0, - "partner":"7q9z" - }, { "sim":69.0, "partner":"7q9x" }, { "sim":69.0, - "partner":"5e0o" + "partner":"7q9z" }, { "sim":69.0, - "partner":"4bzc" + "partner":"5e0o" }, { "sim":69.0, @@ -734679,16 +737718,12 @@ }, { "sim":69.0, - "partner":"6dwk" + "partner":"6dwd" }, { "sim":69.0, "partner":"4qg2" }, - { - "sim":69.0, - "partner":"6dwd" - }, { "sim":69.0, "partner":"7s2y" @@ -734739,11 +737774,15 @@ }, { "sim":69.0, - "partner":"4e85" + "partner":"6dwk" }, { - "sim":68.0, - "partner":"4d1f" + "sim":69.0, + "partner":"4bzc" + }, + { + "sim":69.0, + "partner":"4e85" }, { "sim":68.0, @@ -734753,6 +737792,10 @@ "sim":68.0, "partner":"4d0u" }, + { + "sim":68.0, + "partner":"4d1f" + }, { "sim":68.0, "partner":"5fld" @@ -734777,10 +737820,6 @@ "sim":68.0, "partner":"5zi0" }, - { - "sim":68.0, - "partner":"2zbb" - }, { "sim":68.0, "partner":"3e4o" @@ -734793,6 +737832,10 @@ "sim":68.0, "partner":"3e4q" }, + { + "sim":68.0, + "partner":"2zbb" + }, { "sim":68.0, "partner":"6nok" @@ -735105,10 +738148,6 @@ "sim":58.0, "partner":"2iss" }, - { - "sim":58.0, - "partner":"3g3d" - }, { "sim":58.0, "partner":"3bvj" @@ -735125,6 +738164,10 @@ "sim":58.0, "partner":"4hkp" }, + { + "sim":58.0, + "partner":"3g3d" + }, { "sim":57.0, "partner":"2lj9" @@ -735171,11 +738214,11 @@ }, { "sim":57.0, - "partner":"4f0v" + "partner":"4f0w" }, { "sim":57.0, - "partner":"4f0w" + "partner":"4f0v" }, { "sim":57.0, @@ -735269,10 +738312,6 @@ "sim":56.0, "partner":"6mhf" }, - { - "sim":56.0, - "partner":"7ajm" - }, { "sim":56.0, "partner":"7a4r" @@ -735287,23 +738326,7 @@ }, { "sim":56.0, - "partner":"7a53" - }, - { - "sim":56.0, - "partner":"7ajw" - }, - { - "sim":56.0, - "partner":"7akb" - }, - { - "sim":56.0, - "partner":"7ajy" - }, - { - "sim":56.0, - "partner":"7a5l" + "partner":"7ajm" }, { "sim":56.0, @@ -735365,17 +738388,33 @@ "sim":56.0, "partner":"7aka" }, + { + "sim":56.0, + "partner":"7a53" + }, { "sim":56.0, "partner":"7akl" }, { "sim":56.0, - "partner":"4rl1" + "partner":"7ajw" }, { "sim":56.0, - "partner":"2cj9" + "partner":"7akb" + }, + { + "sim":56.0, + "partner":"7ajy" + }, + { + "sim":56.0, + "partner":"7a5l" + }, + { + "sim":56.0, + "partner":"4rl1" }, { "sim":56.0, @@ -735389,6 +738428,10 @@ "sim":56.0, "partner":"2cjb" }, + { + "sim":56.0, + "partner":"2cj9" + }, { "sim":56.0, "partner":"6xsx" @@ -735407,15 +738450,15 @@ }, { "sim":56.0, - "partner":"5tsh" + "partner":"6olj" }, { "sim":56.0, - "partner":"6olj" + "partner":"5tsg" }, { "sim":56.0, - "partner":"5tsg" + "partner":"5tsh" }, { "sim":56.0, @@ -735457,10 +738500,6 @@ "sim":55.0, "partner":"4luj" }, - { - "sim":55.0, - "partner":"6o98" - }, { "sim":55.0, "partner":"7jh2" @@ -735475,19 +738514,15 @@ }, { "sim":55.0, - "partner":"2per" - }, - { - "sim":55.0, - "partner":"5w1q" + "partner":"6o98" }, { "sim":55.0, - "partner":"7kqj" + "partner":"2per" }, { "sim":55.0, - "partner":"6vqf" + "partner":"5w1q" }, { "sim":55.0, @@ -735523,11 +738558,11 @@ }, { "sim":55.0, - "partner":"3d9h" + "partner":"6p9f" }, { "sim":55.0, - "partner":"6p9f" + "partner":"3d9h" }, { "sim":55.0, @@ -735539,15 +738574,19 @@ }, { "sim":55.0, - "partner":"5ita" + "partner":"6vqf" }, { "sim":55.0, - "partner":"6unv" + "partner":"7kqj" }, { "sim":55.0, - "partner":"3p8e" + "partner":"5ita" + }, + { + "sim":55.0, + "partner":"6unv" }, { "sim":55.0, @@ -735565,6 +738604,10 @@ "sim":55.0, "partner":"3p8p" }, + { + "sim":55.0, + "partner":"3p8e" + }, { "sim":55.0, "partner":"5y1d" @@ -735583,11 +738626,11 @@ }, { "sim":55.0, - "partner":"3wcf" + "partner":"3wc9" }, { "sim":55.0, - "partner":"3wc9" + "partner":"3wcf" }, { "sim":55.0, @@ -735639,28 +738682,12 @@ }, { "sim":55.0, - "partner":"4wya" - }, - { - "sim":55.0, - "partner":"4wyf" - }, - { - "sim":55.0, - "partner":"4cxq" - }, - { - "sim":55.0, - "partner":"5kgs" + "partner":"4cxr" }, { "sim":55.0, "partner":"4wyg" }, - { - "sim":55.0, - "partner":"4cxr" - }, { "sim":55.0, "partner":"4xjl" @@ -735725,17 +738752,29 @@ "sim":55.0, "partner":"3tfu" }, + { + "sim":55.0, + "partner":"4wya" + }, { "sim":55.0, "partner":"4wye" }, { "sim":55.0, - "partner":"2inr" + "partner":"4wyf" }, { "sim":55.0, - "partner":"5kdn" + "partner":"4cxq" + }, + { + "sim":55.0, + "partner":"5kgs" + }, + { + "sim":55.0, + "partner":"2inr" }, { "sim":55.0, @@ -735745,6 +738784,10 @@ "sim":55.0, "partner":"5kdu" }, + { + "sim":55.0, + "partner":"5kdn" + }, { "sim":55.0, "partner":"5xzr" @@ -735787,11 +738830,11 @@ }, { "sim":54.0, - "partner":"5c7p" + "partner":"4kpc" }, { "sim":54.0, - "partner":"4kpc" + "partner":"5c7p" }, { "sim":54.0, @@ -735809,10 +738852,6 @@ "sim":54.0, "partner":"2ouk" }, - { - "sim":54.0, - "partner":"7e16" - }, { "sim":54.0, "partner":"3c4j" @@ -735829,6 +738868,10 @@ "sim":54.0, "partner":"2olk" }, + { + "sim":54.0, + "partner":"7e16" + }, { "sim":54.0, "partner":"7v03" @@ -735887,11 +738930,11 @@ }, { "sim":54.0, - "partner":"5lsg" + "partner":"6t9c" }, { "sim":54.0, - "partner":"6t9c" + "partner":"5lsg" }, { "sim":54.0, @@ -735931,15 +738974,15 @@ }, { "sim":54.0, - "partner":"1vsu" + "partner":"1vsv" }, { "sim":54.0, - "partner":"1vsv" + "partner":"3cif" }, { "sim":54.0, - "partner":"3cif" + "partner":"1vsu" }, { "sim":54.0, @@ -735983,11 +739026,11 @@ }, { "sim":54.0, - "partner":"3upu" + "partner":"8gme" }, { "sim":54.0, - "partner":"8gme" + "partner":"3upu" }, { "sim":54.0, @@ -736011,7 +739054,7 @@ }, { "sim":54.0, - "partner":"5m12" + "partner":"6gwg" }, { "sim":54.0, @@ -736019,31 +739062,31 @@ }, { "sim":54.0, - "partner":"6gwf" + "partner":"6gta" }, { "sim":54.0, - "partner":"6gwg" + "partner":"5m16" }, { "sim":54.0, - "partner":"5m16" + "partner":"6gvd" }, { "sim":54.0, - "partner":"6gta" + "partner":"5m0x" }, { "sim":54.0, - "partner":"6gvd" + "partner":"6gx8" }, { "sim":54.0, - "partner":"5m0x" + "partner":"5m12" }, { "sim":54.0, - "partner":"6gx8" + "partner":"6gwf" }, { "sim":53.0, @@ -736093,14 +739136,6 @@ "sim":53.0, "partner":"7ck4" }, - { - "sim":53.0, - "partner":"5scp" - }, - { - "sim":53.0, - "partner":"5scq" - }, { "sim":53.0, "partner":"5scr" @@ -736201,6 +739236,14 @@ "sim":53.0, "partner":"5sco" }, + { + "sim":53.0, + "partner":"5scp" + }, + { + "sim":53.0, + "partner":"5scq" + }, { "sim":53.0, "partner":"4ay3" @@ -736215,11 +739258,11 @@ }, { "sim":53.0, - "partner":"6uv7" + "partner":"6uvi" }, { "sim":53.0, - "partner":"6uvi" + "partner":"6uv7" }, { "sim":53.0, @@ -736257,14 +739300,6 @@ "sim":53.0, "partner":"6vio" }, - { - "sim":53.0, - "partner":"6tlm" - }, - { - "sim":53.0, - "partner":"6tlq" - }, { "sim":53.0, "partner":"6tlt" @@ -736297,6 +739332,14 @@ "sim":53.0, "partner":"6t50" }, + { + "sim":53.0, + "partner":"6tlm" + }, + { + "sim":53.0, + "partner":"6tlq" + }, { "sim":53.0, "partner":"6pdk" @@ -736351,23 +739394,23 @@ }, { "sim":53.0, - "partner":"4bf9" + "partner":"2g7m" }, { "sim":53.0, - "partner":"4bfa" + "partner":"2fg6" }, { "sim":53.0, - "partner":"2g7m" + "partner":"2fg7" }, { "sim":53.0, - "partner":"2fg6" + "partner":"4bf9" }, { "sim":53.0, - "partner":"2fg7" + "partner":"4bfa" }, { "sim":53.0, @@ -736393,21 +739436,17 @@ "sim":53.0, "partner":"2fsn" }, - { - "sim":53.0, - "partner":"5zkj" - }, { "sim":53.0, "partner":"6iid" }, { "sim":53.0, - "partner":"7js3" + "partner":"8g5w" }, { "sim":53.0, - "partner":"8g5w" + "partner":"7js3" }, { "sim":53.0, @@ -736419,19 +739458,19 @@ }, { "sim":53.0, - "partner":"5zki" + "partner":"7txg" }, { "sim":53.0, - "partner":"7txg" + "partner":"5zki" }, { "sim":53.0, - "partner":"5v8y" + "partner":"5zkj" }, { "sim":53.0, - "partner":"5jyf" + "partner":"5v8y" }, { "sim":53.0, @@ -736463,19 +739502,19 @@ }, { "sim":53.0, - "partner":"7zgj" + "partner":"5jyf" }, { "sim":53.0, - "partner":"7zgk" + "partner":"7zgj" }, { "sim":53.0, - "partner":"4myg" + "partner":"7zgk" }, { "sim":53.0, - "partner":"3c1y" + "partner":"4myg" }, { "sim":53.0, @@ -736503,23 +739542,19 @@ }, { "sim":53.0, - "partner":"7ugb" - }, - { - "sim":53.0, - "partner":"8t0w" + "partner":"3c1y" }, { "sim":53.0, - "partner":"8t0u" + "partner":"7ugb" }, { "sim":53.0, - "partner":"3dyh" + "partner":"8t0w" }, { "sim":53.0, - "partner":"4rxd" + "partner":"8t0u" }, { "sim":53.0, @@ -736561,6 +739596,14 @@ "sim":53.0, "partner":"3dyg" }, + { + "sim":53.0, + "partner":"4rxd" + }, + { + "sim":53.0, + "partner":"3dyh" + }, { "sim":53.0, "partner":"4wwv" @@ -736613,10 +739656,6 @@ "sim":53.0, "partner":"3wx9" }, - { - "sim":53.0, - "partner":"7tfc" - }, { "sim":53.0, "partner":"7tfe" @@ -736629,6 +739668,10 @@ "sim":53.0, "partner":"8ovh" }, + { + "sim":53.0, + "partner":"7tfc" + }, { "sim":53.0, "partner":"6hr5" @@ -736649,21 +739692,17 @@ "sim":53.0, "partner":"3khz" }, - { - "sim":53.0, - "partner":"4mdo" - }, { "sim":53.0, "partner":"4mdp" }, { "sim":53.0, - "partner":"7ozc" + "partner":"4mdo" }, { "sim":53.0, - "partner":"8iat" + "partner":"7ozc" }, { "sim":53.0, @@ -736687,15 +739726,15 @@ }, { "sim":53.0, - "partner":"6xsz" + "partner":"8iat" }, { "sim":53.0, - "partner":"6xt1" + "partner":"6xsz" }, { "sim":53.0, - "partner":"6crm" + "partner":"6xt1" }, { "sim":53.0, @@ -736711,16 +739750,20 @@ }, { "sim":53.0, - "partner":"7onw" + "partner":"6crm" }, { "sim":53.0, - "partner":"2vbg" + "partner":"7onw" }, { "sim":53.0, "partner":"2vbf" }, + { + "sim":53.0, + "partner":"2vbg" + }, { "sim":53.0, "partner":"5fqe" @@ -736795,35 +739838,35 @@ }, { "sim":53.0, - "partner":"3ahc" + "partner":"3ahf" }, { "sim":53.0, - "partner":"3ahd" + "partner":"3ahg" }, { "sim":53.0, - "partner":"3ahe" + "partner":"3ahh" }, { "sim":53.0, - "partner":"3ahf" + "partner":"3ahi" }, { "sim":53.0, - "partner":"3ahg" + "partner":"3ahj" }, { "sim":53.0, - "partner":"3ahh" + "partner":"3ahc" }, { "sim":53.0, - "partner":"3ahi" + "partner":"3ahd" }, { "sim":53.0, - "partner":"3ahj" + "partner":"3ahe" }, { "sim":53.0, @@ -736887,15 +739930,15 @@ }, { "sim":52.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":52.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":52.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":52.0, @@ -736917,10 +739960,6 @@ "sim":52.0, "partner":"6lag" }, - { - "sim":52.0, - "partner":"3sw1" - }, { "sim":52.0, "partner":"5j3w" @@ -736933,13 +739972,17 @@ "sim":52.0, "partner":"5j4e" }, + { + "sim":52.0, + "partner":"6gg9" + }, { "sim":52.0, "partner":"7r4s" }, { "sim":52.0, - "partner":"6gg9" + "partner":"3sw1" }, { "sim":52.0, @@ -736969,21 +740012,17 @@ "sim":52.0, "partner":"8oov" }, - { - "sim":52.0, - "partner":"1x24" - }, { "sim":52.0, "partner":"1zcl" }, { "sim":52.0, - "partner":"3rz2" + "partner":"1x24" }, { "sim":52.0, - "partner":"5l9k" + "partner":"3rz2" }, { "sim":52.0, @@ -737003,16 +740042,20 @@ }, { "sim":52.0, - "partner":"2ccg" + "partner":"5l9k" }, { "sim":52.0, - "partner":"1wc6" + "partner":"2ccg" }, { "sim":52.0, "partner":"1wc1" }, + { + "sim":52.0, + "partner":"1wc6" + }, { "sim":52.0, "partner":"6q2s" @@ -737115,19 +740158,19 @@ }, { "sim":52.0, - "partner":"4rni" + "partner":"4rnj" }, { "sim":52.0, - "partner":"4rnj" + "partner":"4rni" }, { "sim":52.0, - "partner":"5zm4" + "partner":"6pwn" }, { "sim":52.0, - "partner":"6pwn" + "partner":"6uzh" }, { "sim":52.0, @@ -737139,15 +740182,15 @@ }, { "sim":52.0, - "partner":"6uzh" + "partner":"5zm2" }, { "sim":52.0, - "partner":"5zm2" + "partner":"5zm3" }, { "sim":52.0, - "partner":"5zm3" + "partner":"5zm4" }, { "sim":52.0, @@ -737183,11 +740226,11 @@ }, { "sim":52.0, - "partner":"5okt" + "partner":"7nzy" }, { "sim":52.0, - "partner":"7nzy" + "partner":"5okt" }, { "sim":52.0, @@ -737289,25 +740332,13 @@ "sim":52.0, "partner":"3dt1" }, - { - "sim":52.0, - "partner":"6wa9" - }, { "sim":52.0, "partner":"6wa6" }, { "sim":52.0, - "partner":"4i2f" - }, - { - "sim":52.0, - "partner":"4qzb" - }, - { - "sim":52.0, - "partner":"4i2g" + "partner":"6wa9" }, { "sim":52.0, @@ -737417,6 +740448,18 @@ "sim":52.0, "partner":"6b1i" }, + { + "sim":52.0, + "partner":"4i2f" + }, + { + "sim":52.0, + "partner":"4qzb" + }, + { + "sim":52.0, + "partner":"4i2g" + }, { "sim":52.0, "partner":"6go3" @@ -737443,11 +740486,11 @@ }, { "sim":52.0, - "partner":"2gqn" + "partner":"2fq6" }, { "sim":52.0, - "partner":"2fq6" + "partner":"2gqn" }, { "sim":52.0, @@ -737551,11 +740594,11 @@ }, { "sim":52.0, - "partner":"5dt7" + "partner":"5dt5" }, { "sim":52.0, - "partner":"5dt5" + "partner":"5dt7" }, { "sim":52.0, @@ -737591,11 +740634,11 @@ }, { "sim":52.0, - "partner":"1zdl" + "partner":"1zkq" }, { "sim":52.0, - "partner":"1zkq" + "partner":"1zdl" }, { "sim":52.0, @@ -737685,21 +740728,17 @@ "sim":52.0, "partner":"7laf" }, - { - "sim":52.0, - "partner":"3o8y" - }, { "sim":52.0, "partner":"7ttj" }, { "sim":52.0, - "partner":"7ttk" + "partner":"6n2w" }, { "sim":52.0, - "partner":"6n2w" + "partner":"7ttk" }, { "sim":52.0, @@ -737723,7 +740762,7 @@ }, { "sim":52.0, - "partner":"6k8s" + "partner":"3o8y" }, { "sim":52.0, @@ -737735,15 +740774,15 @@ }, { "sim":52.0, - "partner":"4nre" + "partner":"6k8s" }, { "sim":52.0, - "partner":"8viy" + "partner":"4nre" }, { "sim":52.0, - "partner":"6jr8" + "partner":"8viy" }, { "sim":52.0, @@ -737753,6 +740792,10 @@ "sim":52.0, "partner":"6jr7" }, + { + "sim":52.0, + "partner":"6jr8" + }, { "sim":51.0, "partner":"2lo4" @@ -737773,10 +740816,6 @@ "sim":51.0, "partner":"7ycu" }, - { - "sim":51.0, - "partner":"7vp1" - }, { "sim":51.0, "partner":"7vp2" @@ -737793,6 +740832,10 @@ "sim":51.0, "partner":"7vp4" }, + { + "sim":51.0, + "partner":"7vp1" + }, { "sim":51.0, "partner":"2kgo" @@ -737841,10 +740884,6 @@ "sim":51.0, "partner":"6aq7" }, - { - "sim":51.0, - "partner":"4hmr" - }, { "sim":51.0, "partner":"2wgn" @@ -737867,19 +740906,19 @@ }, { "sim":51.0, - "partner":"2y78" + "partner":"4hmr" }, { "sim":51.0, - "partner":"2i39" + "partner":"2y78" }, { "sim":51.0, - "partner":"4o1h" + "partner":"2i39" }, { "sim":51.0, - "partner":"3qna" + "partner":"4o1h" }, { "sim":51.0, @@ -737893,6 +740932,10 @@ "sim":51.0, "partner":"3qn9" }, + { + "sim":51.0, + "partner":"3qna" + }, { "sim":51.0, "partner":"6l8p" @@ -737925,10 +740968,6 @@ "sim":51.0, "partner":"2bze" }, - { - "sim":51.0, - "partner":"3rg6" - }, { "sim":51.0, "partner":"2wvw" @@ -737943,7 +740982,7 @@ }, { "sim":51.0, - "partner":"5hso" + "partner":"3rg6" }, { "sim":51.0, @@ -737961,6 +741000,10 @@ "sim":51.0, "partner":"5hsm" }, + { + "sim":51.0, + "partner":"5hso" + }, { "sim":51.0, "partner":"5luv" @@ -737971,11 +741014,11 @@ }, { "sim":51.0, - "partner":"5aoz" + "partner":"6o20" }, { "sim":51.0, - "partner":"6o20" + "partner":"5aoz" }, { "sim":51.0, @@ -737987,31 +741030,31 @@ }, { "sim":51.0, - "partner":"7xtl" + "partner":"3l20" }, { "sim":51.0, - "partner":"3l20" + "partner":"7xtl" }, { "sim":51.0, - "partner":"5ujf" + "partner":"4gzd" }, { "sim":51.0, - "partner":"4gzc" + "partner":"6gum" }, { "sim":51.0, - "partner":"4gzd" + "partner":"6gv3" }, { "sim":51.0, - "partner":"6gum" + "partner":"5ujf" }, { "sim":51.0, - "partner":"6gv3" + "partner":"4gzc" }, { "sim":51.0, @@ -738023,15 +741066,15 @@ }, { "sim":51.0, - "partner":"5t0z" + "partner":"7efj" }, { "sim":51.0, - "partner":"7efj" + "partner":"7f0m" }, { "sim":51.0, - "partner":"7f0m" + "partner":"5t0z" }, { "sim":51.0, @@ -738057,10 +741100,6 @@ "sim":51.0, "partner":"7xh4" }, - { - "sim":51.0, - "partner":"6f3z" - }, { "sim":51.0, "partner":"5lnm" @@ -738071,19 +741110,19 @@ }, { "sim":51.0, - "partner":"2d7j" + "partner":"6f3z" }, { "sim":51.0, - "partner":"6pj9" + "partner":"2d7j" }, { "sim":51.0, - "partner":"6pja" + "partner":"6pjp" }, { "sim":51.0, - "partner":"6pjp" + "partner":"6pjq" }, { "sim":51.0, @@ -738091,11 +741130,11 @@ }, { "sim":51.0, - "partner":"6pjq" + "partner":"6pjr" }, { "sim":51.0, - "partner":"6pjr" + "partner":"6pju" }, { "sim":51.0, @@ -738105,10 +741144,6 @@ "sim":51.0, "partner":"5f5d" }, - { - "sim":51.0, - "partner":"6pju" - }, { "sim":51.0, "partner":"4njp" @@ -738131,15 +741166,19 @@ }, { "sim":51.0, - "partner":"5f5j" + "partner":"6pj5" }, { "sim":51.0, - "partner":"6pj5" + "partner":"6pj7" }, { "sim":51.0, - "partner":"6pj7" + "partner":"5f5j" + }, + { + "sim":51.0, + "partner":"6pj8" }, { "sim":51.0, @@ -738147,7 +741186,11 @@ }, { "sim":51.0, - "partner":"6pj8" + "partner":"6pj9" + }, + { + "sim":51.0, + "partner":"6pja" }, { "sim":51.0, @@ -738167,11 +741210,11 @@ }, { "sim":51.0, - "partner":"6nko" + "partner":"4oki" }, { "sim":51.0, - "partner":"4oki" + "partner":"6nko" }, { "sim":51.0, @@ -738207,19 +741250,19 @@ }, { "sim":51.0, - "partner":"5n7o" + "partner":"6hry" }, { "sim":51.0, - "partner":"6hry" + "partner":"5n7o" }, { "sim":51.0, - "partner":"5n1c" + "partner":"6hrz" }, { "sim":51.0, - "partner":"6hrz" + "partner":"5n1c" }, { "sim":51.0, @@ -738267,27 +741310,27 @@ }, { "sim":51.0, - "partner":"8vip" + "partner":"7p1y" }, { "sim":51.0, - "partner":"8viq" + "partner":"8vit" }, { "sim":51.0, - "partner":"7p1y" + "partner":"2xx3" }, { "sim":51.0, - "partner":"8vir" + "partner":"8vip" }, { "sim":51.0, - "partner":"8vit" + "partner":"8viq" }, { "sim":51.0, - "partner":"2xx3" + "partner":"8vir" }, { "sim":51.0, @@ -738311,16 +741354,12 @@ }, { "sim":51.0, - "partner":"7o2t" + "partner":"6z17" }, { "sim":51.0, "partner":"7o2u" }, - { - "sim":51.0, - "partner":"6z17" - }, { "sim":51.0, "partner":"6yz3" @@ -738337,6 +741376,10 @@ "sim":51.0, "partner":"6z5k" }, + { + "sim":51.0, + "partner":"7o2t" + }, { "sim":51.0, "partner":"4d7l" @@ -738477,18 +741520,6 @@ "sim":51.0, "partner":"4qts" }, - { - "sim":51.0, - "partner":"6ub4" - }, - { - "sim":51.0, - "partner":"6ub5" - }, - { - "sim":51.0, - "partner":"6ub6" - }, { "sim":51.0, "partner":"5t65" @@ -738515,15 +741546,15 @@ }, { "sim":51.0, - "partner":"5ds3" + "partner":"6ub4" }, { "sim":51.0, - "partner":"6bhv" + "partner":"6ub5" }, { "sim":51.0, - "partner":"1z5z" + "partner":"6ub6" }, { "sim":51.0, @@ -738553,6 +741584,18 @@ "sim":51.0, "partner":"6nrj" }, + { + "sim":51.0, + "partner":"6bhv" + }, + { + "sim":51.0, + "partner":"5ds3" + }, + { + "sim":51.0, + "partner":"1z5z" + }, { "sim":51.0, "partner":"2rhr" @@ -738579,11 +741622,11 @@ }, { "sim":51.0, - "partner":"5c2d" + "partner":"6dli" }, { "sim":51.0, - "partner":"6dli" + "partner":"5c2d" }, { "sim":51.0, @@ -738639,11 +741682,11 @@ }, { "sim":51.0, - "partner":"6fcn" + "partner":"6fcm" }, { "sim":51.0, - "partner":"6fcm" + "partner":"6fcn" }, { "sim":51.0, @@ -738659,24 +741702,12 @@ }, { "sim":51.0, - "partner":"5coq" - }, - { - "sim":51.0, - "partner":"5cpb" - }, - { - "sim":51.0, - "partner":"5mtr" + "partner":"4oxk" }, { "sim":51.0, "partner":"5ugt" }, - { - "sim":51.0, - "partner":"4oxk" - }, { "sim":51.0, "partner":"5ugu" @@ -738687,15 +741718,15 @@ }, { "sim":51.0, - "partner":"4oxn" + "partner":"6yuu" }, { "sim":51.0, - "partner":"4oyr" + "partner":"4oxn" }, { "sim":51.0, - "partner":"6yuu" + "partner":"4oyr" }, { "sim":51.0, @@ -738721,13 +741752,21 @@ "sim":51.0, "partner":"5cp8" }, + { + "sim":51.0, + "partner":"5mtr" + }, { "sim":51.0, "partner":"5ugs" }, { "sim":51.0, - "partner":"5lto" + "partner":"5cpb" + }, + { + "sim":51.0, + "partner":"5coq" }, { "sim":51.0, @@ -738753,6 +741792,10 @@ "sim":51.0, "partner":"4cp2" }, + { + "sim":51.0, + "partner":"5lto" + }, { "sim":51.0, "partner":"5e0n" @@ -738773,10 +741816,6 @@ "sim":51.0, "partner":"1w4t" }, - { - "sim":51.0, - "partner":"3s3h" - }, { "sim":51.0, "partner":"3s3k" @@ -738791,7 +741830,7 @@ }, { "sim":51.0, - "partner":"7xif" + "partner":"3s3h" }, { "sim":51.0, @@ -738805,6 +741844,10 @@ "sim":51.0, "partner":"7xii" }, + { + "sim":51.0, + "partner":"7xif" + }, { "sim":51.0, "partner":"7e4m" @@ -738899,15 +741942,15 @@ }, { "sim":51.0, - "partner":"4w7v" + "partner":"4w7u" }, { "sim":51.0, - "partner":"4w7w" + "partner":"4w7v" }, { "sim":51.0, - "partner":"4w7u" + "partner":"4w7w" }, { "sim":51.0, @@ -738929,14 +741972,6 @@ "sim":51.0, "partner":"7cgv" }, - { - "sim":51.0, - "partner":"5gg5" - }, - { - "sim":51.0, - "partner":"5xd1" - }, { "sim":51.0, "partner":"5gg6" @@ -738949,6 +741984,10 @@ "sim":51.0, "partner":"5xd3" }, + { + "sim":51.0, + "partner":"6m6y" + }, { "sim":51.0, "partner":"5gg7" @@ -738959,11 +741998,11 @@ }, { "sim":51.0, - "partner":"5xd5" + "partner":"6m65" }, { "sim":51.0, - "partner":"6m6y" + "partner":"5xd5" }, { "sim":51.0, @@ -738973,10 +742012,6 @@ "sim":51.0, "partner":"5hos" }, - { - "sim":51.0, - "partner":"6m65" - }, { "sim":51.0, "partner":"5gg9" @@ -739005,6 +742040,14 @@ "sim":51.0, "partner":"6m69" }, + { + "sim":51.0, + "partner":"5gg5" + }, + { + "sim":51.0, + "partner":"5xd1" + }, { "sim":51.0, "partner":"5m8b" @@ -739057,10 +742100,6 @@ "sim":51.0, "partner":"7voc" }, - { - "sim":51.0, - "partner":"4m1i" - }, { "sim":51.0, "partner":"5b6k" @@ -739081,6 +742120,10 @@ "sim":51.0, "partner":"4m1h" }, + { + "sim":51.0, + "partner":"4m1i" + }, { "sim":51.0, "partner":"6eow" @@ -739133,10 +742176,6 @@ "sim":51.0, "partner":"4ot7" }, - { - "sim":51.0, - "partner":"6put" - }, { "sim":51.0, "partner":"6puw" @@ -739151,15 +742190,15 @@ }, { "sim":51.0, - "partner":"5u1c" + "partner":"6puz" }, { "sim":51.0, - "partner":"6puz" + "partner":"5u1c" }, { "sim":51.0, - "partner":"6ojx" + "partner":"6put" }, { "sim":51.0, @@ -739191,16 +742230,20 @@ }, { "sim":51.0, - "partner":"7dmb" + "partner":"6ojx" }, { "sim":51.0, - "partner":"8bao" + "partner":"7dmb" }, { "sim":51.0, "partner":"5j8x" }, + { + "sim":51.0, + "partner":"8bao" + }, { "sim":51.0, "partner":"5tzb" @@ -739277,10 +742320,6 @@ "sim":51.0, "partner":"3k01" }, - { - "sim":51.0, - "partner":"4lre" - }, { "sim":51.0, "partner":"4lrf" @@ -739315,11 +742354,11 @@ }, { "sim":51.0, - "partner":"5xpj" + "partner":"4lre" }, { "sim":51.0, - "partner":"5dvi" + "partner":"5xpj" }, { "sim":51.0, @@ -739329,6 +742368,10 @@ "sim":51.0, "partner":"5dvf" }, + { + "sim":51.0, + "partner":"5dvi" + }, { "sim":51.0, "partner":"2zvi" @@ -739399,27 +742442,27 @@ }, { "sim":51.0, - "partner":"6ry0" + "partner":"6ry5" }, { "sim":51.0, - "partner":"6ry1" + "partner":"6ry6" }, { "sim":51.0, - "partner":"6ry2" + "partner":"6ry7" }, { "sim":51.0, - "partner":"6ry5" + "partner":"6ry0" }, { "sim":51.0, - "partner":"6ry6" + "partner":"6ry1" }, { "sim":51.0, - "partner":"6ry7" + "partner":"6ry2" }, { "sim":51.0, @@ -739517,14 +742560,6 @@ "sim":51.0, "partner":"5hat" }, - { - "sim":51.0, - "partner":"5hjx" - }, - { - "sim":51.0, - "partner":"5koz" - }, { "sim":51.0, "partner":"5hjy" @@ -739545,6 +742580,10 @@ "sim":51.0, "partner":"4lf1" }, + { + "sim":51.0, + "partner":"5koz" + }, { "sim":51.0, "partner":"4lf2" @@ -739555,15 +742594,15 @@ }, { "sim":51.0, - "partner":"7jrl" + "partner":"5hjx" }, { "sim":51.0, - "partner":"5hqm" + "partner":"7jrl" }, { "sim":51.0, - "partner":"6rk2" + "partner":"5hqm" }, { "sim":51.0, @@ -739579,19 +742618,19 @@ }, { "sim":51.0, - "partner":"6jmw" + "partner":"6rk2" }, { "sim":51.0, - "partner":"6jzs" + "partner":"6jmw" }, { "sim":51.0, - "partner":"5l77" + "partner":"6jzs" }, { "sim":51.0, - "partner":"6pt4" + "partner":"5l77" }, { "sim":51.0, @@ -739605,6 +742644,10 @@ "sim":51.0, "partner":"6ptk" }, + { + "sim":51.0, + "partner":"6pt4" + }, { "sim":51.0, "partner":"6rim" @@ -739733,10 +742776,6 @@ "sim":51.0, "partner":"7all" }, - { - "sim":51.0, - "partner":"3qp9" - }, { "sim":51.0, "partner":"3sur" @@ -739773,13 +742812,17 @@ "sim":51.0, "partner":"3gh7" }, + { + "sim":51.0, + "partner":"3qp9" + }, { "sim":51.0, "partner":"6l4o" }, { "sim":51.0, - "partner":"6p00" + "partner":"6p2v" }, { "sim":51.0, @@ -739787,7 +742830,7 @@ }, { "sim":51.0, - "partner":"6p2v" + "partner":"6p00" }, { "sim":51.0, @@ -739809,14 +742852,6 @@ "sim":51.0, "partner":"5kd5" }, - { - "sim":51.0, - "partner":"4ids" - }, - { - "sim":51.0, - "partner":"4jdc" - }, { "sim":51.0, "partner":"7mer" @@ -739877,6 +742912,14 @@ "sim":51.0, "partner":"4lh3" }, + { + "sim":51.0, + "partner":"4ids" + }, + { + "sim":51.0, + "partner":"4jdc" + }, { "sim":51.0, "partner":"3hx6" @@ -739899,11 +742942,11 @@ }, { "sim":51.0, - "partner":"7jwf" + "partner":"7jw4" }, { "sim":51.0, - "partner":"7jw4" + "partner":"7jwf" }, { "sim":51.0, @@ -739923,23 +742966,23 @@ }, { "sim":51.0, - "partner":"7vzz" + "partner":"7vzq" }, { "sim":51.0, - "partner":"7vzu" + "partner":"7vx0" }, { "sim":51.0, - "partner":"7vzq" + "partner":"7vzy" }, { "sim":51.0, - "partner":"7vx0" + "partner":"7vzz" }, { "sim":51.0, - "partner":"7vzy" + "partner":"7vzu" }, { "sim":51.0, @@ -739949,10 +742992,6 @@ "sim":51.0, "partner":"5x7h" }, - { - "sim":51.0, - "partner":"7wlg" - }, { "sim":51.0, "partner":"7wj9" @@ -739981,6 +743020,10 @@ "sim":51.0, "partner":"7wjf" }, + { + "sim":51.0, + "partner":"7wlg" + }, { "sim":51.0, "partner":"3zvr" @@ -739997,14 +743040,6 @@ "sim":51.0, "partner":"3slk" }, - { - "sim":51.0, - "partner":"4j3t" - }, - { - "sim":51.0, - "partner":"4j3u" - }, { "sim":51.0, "partner":"4j3v" @@ -740023,7 +743058,11 @@ }, { "sim":51.0, - "partner":"5y1h" + "partner":"4j3t" + }, + { + "sim":51.0, + "partner":"4j3u" }, { "sim":51.0, @@ -740069,6 +743108,10 @@ "sim":51.0, "partner":"5y3i" }, + { + "sim":51.0, + "partner":"5y1h" + }, { "sim":51.0, "partner":"5wmm" @@ -740109,10 +743152,6 @@ "sim":51.0, "partner":"3va7" }, - { - "sim":51.0, - "partner":"6yt0" - }, { "sim":51.0, "partner":"4zhj" @@ -740129,6 +743168,10 @@ "sim":51.0, "partner":"6ytj" }, + { + "sim":51.0, + "partner":"6yt0" + }, { "sim":50.0, "partner":"4omp" @@ -740313,10 +743356,6 @@ "sim":50.0, "partner":"2ozn" }, - { - "sim":50.0, - "partner":"7c1j" - }, { "sim":50.0, "partner":"7cfw" @@ -740327,12 +743366,16 @@ }, { "sim":50.0, - "partner":"2wja" + "partner":"7c1j" }, { "sim":50.0, "partner":"7a6p" }, + { + "sim":50.0, + "partner":"2wja" + }, { "sim":50.0, "partner":"3w95" @@ -740433,10 +743476,6 @@ "sim":50.0, "partner":"2j8k" }, - { - "sim":50.0, - "partner":"3th5" - }, { "sim":50.0, "partner":"4gzl" @@ -740451,15 +743490,15 @@ }, { "sim":50.0, - "partner":"3p6b" + "partner":"3th5" }, { "sim":50.0, - "partner":"7q4s" + "partner":"3p6b" }, { "sim":50.0, - "partner":"5n2n" + "partner":"7q4s" }, { "sim":50.0, @@ -740467,15 +743506,15 @@ }, { "sim":50.0, - "partner":"3mmn" + "partner":"5n2n" }, { "sim":50.0, - "partner":"3mm4" + "partner":"3mmn" }, { "sim":50.0, - "partner":"3l1u" + "partner":"3mm4" }, { "sim":50.0, @@ -740493,6 +743532,10 @@ "sim":50.0, "partner":"3esr" }, + { + "sim":50.0, + "partner":"3l1u" + }, { "sim":50.0, "partner":"2l22" @@ -740579,31 +743622,31 @@ }, { "sim":50.0, - "partner":"7mnq" + "partner":"7mns" }, { "sim":50.0, - "partner":"7mnr" + "partner":"7mnt" }, { "sim":50.0, - "partner":"7mns" + "partner":"4irb" }, { "sim":50.0, - "partner":"4irb" + "partner":"7mnu" }, { "sim":50.0, - "partner":"7mnt" + "partner":"7mnv" }, { "sim":50.0, - "partner":"7mnu" + "partner":"7mnq" }, { "sim":50.0, - "partner":"7mnv" + "partner":"7mnr" }, { "sim":50.0, @@ -740633,10 +743676,6 @@ "sim":50.0, "partner":"7cg9" }, - { - "sim":50.0, - "partner":"5cvd" - }, { "sim":50.0, "partner":"5cve" @@ -740647,11 +743686,7 @@ }, { "sim":50.0, - "partner":"4bmx" - }, - { - "sim":50.0, - "partner":"4bmy" + "partner":"5cvd" }, { "sim":50.0, @@ -740667,7 +743702,11 @@ }, { "sim":50.0, - "partner":"4da6" + "partner":"4bmx" + }, + { + "sim":50.0, + "partner":"4bmy" }, { "sim":50.0, @@ -740723,15 +743762,15 @@ }, { "sim":50.0, - "partner":"2vh2" + "partner":"4da6" }, { "sim":50.0, - "partner":"2q60" + "partner":"2vh2" }, { "sim":50.0, - "partner":"5h5a" + "partner":"2q60" }, { "sim":50.0, @@ -740741,6 +743780,10 @@ "sim":50.0, "partner":"5owf" }, + { + "sim":50.0, + "partner":"5h5a" + }, { "sim":50.0, "partner":"3h1z" @@ -740805,10 +743848,6 @@ "sim":50.0, "partner":"4y7j" }, - { - "sim":50.0, - "partner":"3dbp" - }, { "sim":50.0, "partner":"3mo7" @@ -740831,11 +743870,11 @@ }, { "sim":50.0, - "partner":"3uic" + "partner":"3dbp" }, { "sim":50.0, - "partner":"4j3f" + "partner":"3uic" }, { "sim":50.0, @@ -740851,31 +743890,35 @@ }, { "sim":50.0, - "partner":"4jqc" + "partner":"4j3f" }, { "sim":50.0, - "partner":"6t2p" + "partner":"6akv" }, { "sim":50.0, - "partner":"2wk1" + "partner":"6t2o" }, { "sim":50.0, - "partner":"6t2q" + "partner":"4jx8" }, { "sim":50.0, - "partner":"6akv" + "partner":"6t2p" }, { "sim":50.0, - "partner":"4jx8" + "partner":"4jqc" }, { "sim":50.0, - "partner":"6t2o" + "partner":"6t2q" + }, + { + "sim":50.0, + "partner":"2wk1" }, { "sim":50.0, @@ -740891,31 +743934,31 @@ }, { "sim":50.0, - "partner":"3quo" + "partner":"3qur" }, { "sim":50.0, - "partner":"3qvf" + "partner":"3qvh" }, { "sim":50.0, - "partner":"3qur" + "partner":"3d40" }, { "sim":50.0, - "partner":"3qvh" + "partner":"3d41" }, { "sim":50.0, - "partner":"3d40" + "partner":"3qun" }, { "sim":50.0, - "partner":"3d41" + "partner":"3quo" }, { "sim":50.0, - "partner":"3qun" + "partner":"3qvf" }, { "sim":50.0, @@ -740931,19 +743974,19 @@ }, { "sim":50.0, - "partner":"7a61" + "partner":"8rwq" }, { "sim":50.0, - "partner":"5uj3" + "partner":"6mnp" }, { "sim":50.0, - "partner":"5uj4" + "partner":"8rwr" }, { "sim":50.0, - "partner":"6mnp" + "partner":"5uj3" }, { "sim":50.0, @@ -740951,7 +743994,11 @@ }, { "sim":50.0, - "partner":"5ul8" + "partner":"8rws" + }, + { + "sim":50.0, + "partner":"5uj4" }, { "sim":50.0, @@ -740965,6 +744012,10 @@ "sim":50.0, "partner":"6d17" }, + { + "sim":50.0, + "partner":"5ul8" + }, { "sim":50.0, "partner":"6d18" @@ -741005,10 +744056,6 @@ "sim":50.0, "partner":"6z24" }, - { - "sim":50.0, - "partner":"4o0q" - }, { "sim":50.0, "partner":"6qwd" @@ -741023,7 +744070,7 @@ }, { "sim":50.0, - "partner":"8rwq" + "partner":"4o0q" }, { "sim":50.0, @@ -741035,15 +744082,15 @@ }, { "sim":50.0, - "partner":"6v7i" + "partner":"8aki" }, { "sim":50.0, - "partner":"8aki" + "partner":"6v7i" }, { "sim":50.0, - "partner":"4o1e" + "partner":"8akj" }, { "sim":50.0, @@ -741055,7 +744102,7 @@ }, { "sim":50.0, - "partner":"8akj" + "partner":"8akk" }, { "sim":50.0, @@ -741063,7 +744110,15 @@ }, { "sim":50.0, - "partner":"8akk" + "partner":"8akl" + }, + { + "sim":50.0, + "partner":"4o1e" + }, + { + "sim":50.0, + "partner":"8akm" }, { "sim":50.0, @@ -741071,11 +744126,15 @@ }, { "sim":50.0, - "partner":"8akl" + "partner":"7a61" }, { "sim":50.0, - "partner":"8akm" + "partner":"8rwo" + }, + { + "sim":50.0, + "partner":"8rwp" }, { "sim":50.0, @@ -741139,11 +744198,11 @@ }, { "sim":50.0, - "partner":"2qj3" + "partner":"7my7" }, { "sim":50.0, - "partner":"7my7" + "partner":"2qj3" }, { "sim":50.0, @@ -741165,14 +744224,6 @@ "sim":50.0, "partner":"5yr7" }, - { - "sim":50.0, - "partner":"2nq6" - }, - { - "sim":50.0, - "partner":"2nq7" - }, { "sim":50.0, "partner":"2b3k" @@ -741215,7 +744266,11 @@ }, { "sim":50.0, - "partner":"2pzm" + "partner":"2nq6" + }, + { + "sim":50.0, + "partner":"2nq7" }, { "sim":50.0, @@ -741227,12 +744282,16 @@ }, { "sim":50.0, - "partner":"6lcn" + "partner":"2pzm" }, { "sim":50.0, "partner":"7x1l" }, + { + "sim":50.0, + "partner":"6lcn" + }, { "sim":50.0, "partner":"7f8d" @@ -741331,99 +744390,99 @@ }, { "sim":50.0, - "partner":"1xoq" + "partner":"1y2b" }, { "sim":50.0, - "partner":"6ind" + "partner":"6imt" }, { "sim":50.0, - "partner":"1xor" + "partner":"1y2c" }, { "sim":50.0, - "partner":"3iak" + "partner":"6ink" }, { "sim":50.0, - "partner":"6imr" + "partner":"1y2d" }, { "sim":50.0, - "partner":"7cbj" + "partner":"1y2e" }, { "sim":50.0, - "partner":"1y2b" + "partner":"6inm" }, { "sim":50.0, - "partner":"6im6" + "partner":"6imb" }, { "sim":50.0, - "partner":"6imt" + "partner":"7cbq" }, { "sim":50.0, - "partner":"1y2c" + "partner":"6imd" }, { "sim":50.0, - "partner":"1y2d" + "partner":"1y2k" }, { "sim":50.0, - "partner":"6ink" + "partner":"6imi" }, { "sim":50.0, - "partner":"1y2e" + "partner":"6imo" }, { "sim":50.0, - "partner":"6inm" + "partner":"6lrm" }, { "sim":50.0, - "partner":"6imb" + "partner":"1xom" }, { "sim":50.0, - "partner":"7cbq" + "partner":"1xon" }, { "sim":50.0, - "partner":"6imd" + "partner":"3k4s" }, { "sim":50.0, - "partner":"1y2k" + "partner":"6ind" }, { "sim":50.0, - "partner":"1xom" + "partner":"1xoq" }, { "sim":50.0, - "partner":"6imi" + "partner":"7cbj" }, { "sim":50.0, - "partner":"6imo" + "partner":"6imr" }, { "sim":50.0, - "partner":"6lrm" + "partner":"1xor" }, { "sim":50.0, - "partner":"1xon" + "partner":"6im6" }, { "sim":50.0, - "partner":"3k4s" + "partner":"3iak" }, { "sim":50.0, @@ -741477,18 +744536,6 @@ "sim":50.0, "partner":"4ilk" }, - { - "sim":50.0, - "partner":"4m25" - }, - { - "sim":50.0, - "partner":"4m2i" - }, - { - "sim":50.0, - "partner":"4ne0" - }, { "sim":50.0, "partner":"4m26" @@ -741525,6 +744572,18 @@ "sim":50.0, "partner":"4m2g" }, + { + "sim":50.0, + "partner":"4m25" + }, + { + "sim":50.0, + "partner":"4m2i" + }, + { + "sim":50.0, + "partner":"4ne0" + }, { "sim":50.0, "partner":"3wcg" @@ -741589,22 +744648,6 @@ "sim":50.0, "partner":"2nqo" }, - { - "sim":50.0, - "partner":"5zzx" - }, - { - "sim":50.0, - "partner":"6a0d" - }, - { - "sim":50.0, - "partner":"5zzy" - }, - { - "sim":50.0, - "partner":"6a0v" - }, { "sim":50.0, "partner":"5zzz" @@ -741745,6 +744788,22 @@ "sim":50.0, "partner":"6a21" }, + { + "sim":50.0, + "partner":"5zzx" + }, + { + "sim":50.0, + "partner":"6a0d" + }, + { + "sim":50.0, + "partner":"5zzy" + }, + { + "sim":50.0, + "partner":"6a0v" + }, { "sim":50.0, "partner":"4gmg" @@ -741775,31 +744834,31 @@ }, { "sim":50.0, - "partner":"6zgp" + "partner":"6y9d" }, { "sim":50.0, - "partner":"6y8j" + "partner":"6zgp" }, { "sim":50.0, - "partner":"6y9c" + "partner":"2qap" }, { "sim":50.0, - "partner":"6y9d" + "partner":"6y8s" }, { "sim":50.0, - "partner":"2qap" + "partner":"2qdg" }, { "sim":50.0, - "partner":"6y8s" + "partner":"6y8j" }, { "sim":50.0, - "partner":"2qdg" + "partner":"6y9c" }, { "sim":50.0, @@ -741815,11 +744874,11 @@ }, { "sim":50.0, - "partner":"5ta7" + "partner":"5ta9" }, { "sim":50.0, - "partner":"5ta9" + "partner":"5ta7" }, { "sim":50.0, @@ -741919,15 +744978,15 @@ }, { "sim":50.0, - "partner":"4euh" + "partner":"4eue" }, { "sim":50.0, - "partner":"4eue" + "partner":"4euf" }, { "sim":50.0, - "partner":"4euf" + "partner":"4euh" }, { "sim":50.0, @@ -741975,15 +745034,15 @@ }, { "sim":50.0, - "partner":"5z8a" + "partner":"5z8k" }, { "sim":50.0, - "partner":"5z8k" + "partner":"5z83" }, { "sim":50.0, - "partner":"5z83" + "partner":"5z8a" }, { "sim":50.0, @@ -742053,10 +745112,6 @@ "sim":50.0, "partner":"3ugq" }, - { - "sim":50.0, - "partner":"4acg" - }, { "sim":50.0, "partner":"4ach" @@ -742071,19 +745126,19 @@ }, { "sim":50.0, - "partner":"5y9h" + "partner":"4acg" }, { "sim":50.0, - "partner":"4il0" + "partner":"5y9h" }, { "sim":50.0, - "partner":"6qps" + "partner":"4il0" }, { "sim":50.0, - "partner":"2wc4" + "partner":"6qps" }, { "sim":50.0, @@ -742199,7 +745254,7 @@ }, { "sim":50.0, - "partner":"2gps" + "partner":"2wc4" }, { "sim":50.0, @@ -742207,11 +745262,15 @@ }, { "sim":50.0, - "partner":"6oi9" + "partner":"2gpw" }, { "sim":50.0, - "partner":"2gpw" + "partner":"2gps" + }, + { + "sim":50.0, + "partner":"6oi9" }, { "sim":50.0, @@ -742249,10 +745308,6 @@ "sim":50.0, "partner":"5ti8" }, - { - "sim":50.0, - "partner":"5v59" - }, { "sim":50.0, "partner":"4dod" @@ -742269,6 +745324,10 @@ "sim":50.0, "partner":"4xeo" }, + { + "sim":50.0, + "partner":"5v59" + }, { "sim":50.0, "partner":"6bia" @@ -742329,10 +745388,6 @@ "sim":50.0, "partner":"4ife" }, - { - "sim":50.0, - "partner":"5uno" - }, { "sim":50.0, "partner":"7m7c" @@ -742351,11 +745406,11 @@ }, { "sim":50.0, - "partner":"4l6w" + "partner":"5uno" }, { "sim":50.0, - "partner":"6x0h" + "partner":"4l6w" }, { "sim":50.0, @@ -742367,15 +745422,15 @@ }, { "sim":50.0, - "partner":"6pop" + "partner":"6x0h" }, { "sim":50.0, - "partner":"6pnu" + "partner":"6pop" }, { "sim":50.0, - "partner":"4dqw" + "partner":"6pnu" }, { "sim":50.0, @@ -742391,12 +745446,16 @@ }, { "sim":50.0, - "partner":"7an1" + "partner":"4dqw" }, { "sim":50.0, "partner":"7oqd" }, + { + "sim":50.0, + "partner":"7an1" + }, { "sim":50.0, "partner":"5m1c" @@ -742515,23 +745574,23 @@ }, { "sim":50.0, - "partner":"7aqu" + "partner":"7cu0" }, { "sim":50.0, - "partner":"7aqv" + "partner":"7cu1" }, { "sim":50.0, - "partner":"7cu0" + "partner":"7cu2" }, { "sim":50.0, - "partner":"7cu1" + "partner":"7aqu" }, { "sim":50.0, - "partner":"7cu2" + "partner":"7aqv" }, { "sim":50.0, @@ -742637,10 +745696,6 @@ "sim":50.0, "partner":"8r72" }, - { - "sim":50.0, - "partner":"2fw3" - }, { "sim":50.0, "partner":"4ep9" @@ -742661,6 +745716,10 @@ "sim":50.0, "partner":"4eph" }, + { + "sim":50.0, + "partner":"2fw3" + }, { "sim":50.0, "partner":"4gw9" @@ -742691,15 +745750,15 @@ }, { "sim":50.0, - "partner":"7w1c" + "partner":"7w1d" }, { "sim":50.0, - "partner":"7w1d" + "partner":"7w1e" }, { "sim":50.0, - "partner":"7w1e" + "partner":"7w1c" }, { "sim":50.0, @@ -742751,15 +745810,15 @@ }, { "sim":50.0, - "partner":"6edw" + "partner":"6edz" }, { "sim":50.0, - "partner":"6edz" + "partner":"6ee1" }, { "sim":50.0, - "partner":"6ee1" + "partner":"6edw" }, { "sim":50.0, @@ -742928,80 +745987,80 @@ "double zeta beta barrel" ], "keywords":[ - "predicted", - "beginning", - "early", - "evolution", - "designs", - "dpbbs", + "life", + "central", + "reconstructed", + "engineering", "molecular", - "many", - "results", - "proteins", - "ob", - "dna", - "similar", - "also", - "common", - "rna", - "although", - "similarities", "quickly", + "adopt", + "beginning", + "however", + "many", "conserved", - "topologies", - "polymerases", - "sh3", + "ob", + "metamorphic", + "indeed", + "indicate", + "diversified", + "biology", "named", - "machines", - "fold", - "means", + "simple", "modern", - "indeed", - "experiments", + "previously", "different", + "rna", + "dna", + "dogma", "remains", - "small", - "simple", - "found", - "ribosomal", - "reconstructed", - "folds", - "evolutionary", - "engineering", - "converted", "furthermore", - "central", - "ancient", - "transformed", - "drive", + "rift", + "structure", + "possess", + "fold", "discover", + "results", + "although", + "also", + "experiments", + "similarities", + "drive", + "transformed", + "means", + "protein", + "topologies", + "proteins", + "ribosomal", + "represented", + "dpbbs", + "enigmatic", + "emerged", + "ancient", "dpbb", + "sequence", + "predicted", + "early", + "small", + "distinct", + "common", + "machines", + "found", "numerous", - "life", - "dogma", - "possess", + "sh3", + "evolution", + "folds", "topologically", - "required", - "adopt", + "converted", "dzbb", - "enigmatic", - "protein", - "represented", + "ancestor", "shares", - "structure", + "designs", + "polymerases", "stage", - "rift", - "sequence", - "biology", - "emerged", - "indicate", - "distinct", + "required", + "similar", "could", - "ancestor", - "however", - "metamorphic", - "diversified", - "previously" + "evolutionary" ], "release_date":"2024-07-03", "publication":"\"An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins\", Nat Commun, 15, 5938-5938", @@ -743042,19 +746101,19 @@ }, { "sim":67.0, - "partner":"8jvq" + "partner":"8jvr" }, { "sim":67.0, - "partner":"8jvr" + "partner":"8jvq" }, { "sim":66.0, - "partner":"8jvx" + "partner":"8jvw" }, { "sim":66.0, - "partner":"8jvw" + "partner":"8jvx" } ], "seq_thr_sim_natural":[ @@ -743084,11 +746143,11 @@ }, { "sim":78.0, - "partner":"7dxt" + "partner":"7dxr" }, { "sim":78.0, - "partner":"7dxr" + "partner":"7dxt" }, { "sim":78.0, @@ -743200,80 +746259,80 @@ "double zeta beta barrel" ], "keywords":[ - "predicted", - "beginning", - "early", - "evolution", - "designs", - "dpbbs", + "life", + "central", + "reconstructed", + "engineering", "molecular", - "many", - "results", - "proteins", - "ob", - "dna", - "similar", - "also", - "common", - "rna", - "although", - "similarities", "quickly", + "adopt", + "beginning", + "however", + "many", "conserved", - "topologies", - "polymerases", - "sh3", + "ob", + "metamorphic", + "indeed", + "indicate", + "diversified", + "biology", "named", - "machines", - "fold", - "means", + "simple", "modern", - "indeed", - "experiments", + "previously", "different", + "rna", + "dna", + "dogma", "remains", - "small", - "simple", - "found", - "ribosomal", - "reconstructed", - "folds", - "evolutionary", - "engineering", - "converted", "furthermore", - "central", - "ancient", - "transformed", - "drive", + "rift", + "structure", + "possess", + "fold", "discover", + "results", + "although", + "also", + "experiments", + "similarities", + "drive", + "transformed", + "means", + "protein", + "topologies", + "proteins", + "ribosomal", + "represented", + "dpbbs", + "enigmatic", + "emerged", + "ancient", "dpbb", + "sequence", + "predicted", + "early", + "small", + "distinct", + "common", + "machines", + "found", "numerous", - "life", - "dogma", - "possess", + "sh3", + "evolution", + "folds", "topologically", - "required", - "adopt", + "converted", "dzbb", - "enigmatic", - "protein", - "represented", + "ancestor", "shares", - "structure", + "designs", + "polymerases", "stage", - "rift", - "sequence", - "biology", - "emerged", - "indicate", - "distinct", + "required", + "similar", "could", - "ancestor", - "however", - "metamorphic", - "diversified", - "previously" + "evolutionary" ], "release_date":"2024-07-03", "publication":"\"An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins\", Nat Commun, 15, 5938-5938", @@ -743314,19 +746373,19 @@ }, { "sim":55.0, - "partner":"8jvq" + "partner":"8jvr" }, { "sim":55.0, - "partner":"8jvr" + "partner":"8jvq" }, { "sim":53.0, - "partner":"8jvx" + "partner":"8jvw" }, { "sim":53.0, - "partner":"8jvw" + "partner":"8jvx" } ], "seq_thr_sim_natural":[ @@ -743352,19 +746411,19 @@ }, { "sim":68.0, - "partner":"7dxu" + "partner":"7dxw" }, { "sim":68.0, - "partner":"7dxw" + "partner":"7dxu" }, { "sim":66.0, - "partner":"7dxt" + "partner":"7dxr" }, { "sim":66.0, - "partner":"7dxr" + "partner":"7dxt" }, { "sim":66.0, @@ -743376,11 +746435,11 @@ }, { "sim":58.0, - "partner":"7du7" + "partner":"7dvh" }, { "sim":58.0, - "partner":"7dvh" + "partner":"7du7" }, { "sim":57.0, @@ -743468,80 +746527,80 @@ "double zeta beta barrel" ], "keywords":[ - "predicted", - "beginning", - "early", - "evolution", - "designs", - "dpbbs", + "life", + "central", + "reconstructed", + "engineering", "molecular", - "many", - "results", - "proteins", - "ob", - "dna", - "similar", - "also", - "common", - "rna", - "although", - "similarities", "quickly", + "adopt", + "beginning", + "however", + "many", "conserved", - "topologies", - "polymerases", - "sh3", + "ob", + "metamorphic", + "indeed", + "indicate", + "diversified", + "biology", "named", - "machines", - "fold", - "means", + "simple", "modern", - "indeed", - "experiments", + "previously", "different", + "rna", + "dna", + "dogma", "remains", - "small", - "simple", - "found", - "ribosomal", - "reconstructed", - "folds", - "evolutionary", - "engineering", - "converted", "furthermore", - "central", - "ancient", - "transformed", - "drive", + "rift", + "structure", + "possess", + "fold", "discover", + "results", + "although", + "also", + "experiments", + "similarities", + "drive", + "transformed", + "means", + "protein", + "topologies", + "proteins", + "ribosomal", + "represented", + "dpbbs", + "enigmatic", + "emerged", + "ancient", "dpbb", + "sequence", + "predicted", + "early", + "small", + "distinct", + "common", + "machines", + "found", "numerous", - "life", - "dogma", - "possess", + "sh3", + "evolution", + "folds", "topologically", - "required", - "adopt", + "converted", "dzbb", - "enigmatic", - "protein", - "represented", + "ancestor", "shares", - "structure", + "designs", + "polymerases", "stage", - "rift", - "sequence", - "biology", - "emerged", - "indicate", - "distinct", + "required", + "similar", "could", - "ancestor", - "however", - "metamorphic", - "diversified", - "previously" + "evolutionary" ], "release_date":"2024-07-03", "publication":"\"An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins\", Nat Commun, 15, 5938-5938", @@ -743586,11 +746645,11 @@ }, { "sim":75.0, - "partner":"8jvx" + "partner":"8jvw" }, { "sim":75.0, - "partner":"8jvw" + "partner":"8jvx" }, { "sim":64.0, @@ -743632,11 +746691,11 @@ }, { "sim":70.0, - "partner":"7dxt" + "partner":"7dxr" }, { "sim":70.0, - "partner":"7dxr" + "partner":"7dxt" }, { "sim":70.0, @@ -743729,80 +746788,80 @@ "rift barrel" ], "keywords":[ - "predicted", - "beginning", - "early", - "evolution", - "designs", - "dpbbs", + "life", + "central", + "reconstructed", + "engineering", "molecular", - "many", - "results", - "proteins", - "ob", - "dna", - "similar", - "also", - "common", - "rna", - "although", - "similarities", "quickly", + "adopt", + "beginning", + "however", + "many", "conserved", - "topologies", - "polymerases", - "sh3", + "ob", + "metamorphic", + "indeed", + "indicate", + "diversified", + "biology", "named", - "machines", - "fold", - "means", + "simple", "modern", - "indeed", - "experiments", + "previously", "different", + "rna", + "dna", + "dogma", "remains", - "small", - "simple", - "found", - "ribosomal", - "reconstructed", - "folds", - "evolutionary", - "engineering", - "converted", "furthermore", - "central", - "ancient", - "transformed", - "drive", + "rift", + "structure", + "possess", + "fold", "discover", + "results", + "although", + "also", + "experiments", + "similarities", + "drive", + "transformed", + "means", + "protein", + "topologies", + "proteins", + "ribosomal", + "represented", + "dpbbs", + "enigmatic", + "emerged", + "ancient", "dpbb", + "sequence", + "predicted", + "early", + "small", + "distinct", + "common", + "machines", + "found", "numerous", - "life", - "dogma", - "possess", + "sh3", + "evolution", + "folds", "topologically", - "required", - "adopt", + "converted", "dzbb", - "enigmatic", - "protein", - "represented", + "ancestor", "shares", - "structure", + "designs", + "polymerases", "stage", - "rift", - "sequence", - "biology", - "emerged", - "indicate", - "distinct", + "required", + "similar", "could", - "ancestor", - "however", - "metamorphic", - "diversified", - "previously" + "evolutionary" ], "release_date":"2024-07-03", "publication":"\"An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins\", Nat Commun, 15, 5938-5938", @@ -743881,15 +746940,15 @@ }, { "sim":59.0, - "partner":"7dxt" + "partner":"7dxr" }, { "sim":59.0, - "partner":"7dxu" + "partner":"7dxt" }, { "sim":59.0, - "partner":"7dxr" + "partner":"7dxu" }, { "sim":58.0, @@ -743962,80 +747021,80 @@ "rift barrel" ], "keywords":[ - "predicted", - "beginning", - "early", - "evolution", - "designs", - "dpbbs", + "life", + "central", + "reconstructed", + "engineering", "molecular", - "many", - "results", - "proteins", - "ob", - "dna", - "similar", - "also", - "common", - "rna", - "although", - "similarities", "quickly", + "adopt", + "beginning", + "however", + "many", "conserved", - "topologies", - "polymerases", - "sh3", + "ob", + "metamorphic", + "indeed", + "indicate", + "diversified", + "biology", "named", - "machines", - "fold", - "means", + "simple", "modern", - "indeed", - "experiments", + "previously", "different", + "rna", + "dna", + "dogma", "remains", - "small", - "simple", - "found", - "ribosomal", - "reconstructed", - "folds", - "evolutionary", - "engineering", - "converted", "furthermore", - "central", - "ancient", - "transformed", - "drive", + "rift", + "structure", + "possess", + "fold", "discover", + "results", + "although", + "also", + "experiments", + "similarities", + "drive", + "transformed", + "means", + "protein", + "topologies", + "proteins", + "ribosomal", + "represented", + "dpbbs", + "enigmatic", + "emerged", + "ancient", "dpbb", + "sequence", + "predicted", + "early", + "small", + "distinct", + "common", + "machines", + "found", "numerous", - "life", - "dogma", - "possess", + "sh3", + "evolution", + "folds", "topologically", - "required", - "adopt", + "converted", "dzbb", - "enigmatic", - "protein", - "represented", + "ancestor", "shares", - "structure", + "designs", + "polymerases", "stage", - "rift", - "sequence", - "biology", - "emerged", - "indicate", - "distinct", + "required", + "similar", "could", - "ancestor", - "however", - "metamorphic", - "diversified", - "previously" + "evolutionary" ], "release_date":"2024-07-03", "publication":"\"An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins\", Nat Commun, 15, 5938-5938", @@ -744114,15 +747173,15 @@ }, { "sim":59.0, - "partner":"7dxt" + "partner":"7dxr" }, { "sim":59.0, - "partner":"7dxu" + "partner":"7dxt" }, { "sim":59.0, - "partner":"7dxr" + "partner":"7dxu" }, { "sim":58.0, @@ -744194,84 +747253,84 @@ ], "subtitle":"Crystal structure of the chimeric protein tkol2_v1", "tags":[ - "ob fold", - "ribosomal protein" + "ribosomal protein", + "ob fold" ], "keywords":[ - "predicted", - "beginning", - "early", - "evolution", - "designs", - "dpbbs", + "life", + "central", + "reconstructed", + "engineering", "molecular", - "many", - "results", - "proteins", - "ob", - "dna", - "similar", - "also", - "common", - "rna", - "although", - "similarities", "quickly", + "adopt", + "beginning", + "however", + "many", "conserved", - "topologies", - "polymerases", - "sh3", + "ob", + "metamorphic", + "indeed", + "indicate", + "diversified", + "biology", "named", - "machines", - "fold", - "means", + "simple", "modern", - "indeed", - "experiments", + "previously", "different", + "rna", + "dna", + "dogma", "remains", - "small", - "simple", - "found", - "ribosomal", - "reconstructed", - "folds", - "evolutionary", - "engineering", - "converted", "furthermore", - "central", - "ancient", - "transformed", - "drive", + "rift", + "structure", + "possess", + "fold", "discover", + "results", + "although", + "also", + "experiments", + "similarities", + "drive", + "transformed", + "means", + "protein", + "topologies", + "proteins", + "ribosomal", + "represented", + "dpbbs", + "enigmatic", + "emerged", + "ancient", "dpbb", + "sequence", + "predicted", + "early", + "small", + "distinct", + "common", + "machines", + "found", "numerous", - "life", - "dogma", - "possess", + "sh3", + "evolution", + "folds", "topologically", - "required", - "adopt", + "converted", "dzbb", - "enigmatic", - "protein", - "represented", + "ancestor", "shares", - "structure", + "designs", + "polymerases", "stage", - "rift", - "sequence", - "biology", - "emerged", - "indicate", - "distinct", + "required", + "similar", "could", - "ancestor", - "however", - "metamorphic", - "diversified", - "previously" + "evolutionary" ], "release_date":"2024-07-03", "publication":"\"An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins\", Nat Commun, 15, 5938-5938", @@ -744346,11 +747405,11 @@ }, { "sim":68.0, - "partner":"4v6u" + "partner":"4v4n" }, { "sim":68.0, - "partner":"4v4n" + "partner":"4v6u" }, { "sim":58.0, @@ -744358,15 +747417,15 @@ }, { "sim":58.0, - "partner":"1ffk" + "partner":"1k8a" }, { "sim":58.0, - "partner":"1jj2" + "partner":"1ffk" }, { "sim":58.0, - "partner":"1k8a" + "partner":"1jj2" }, { "sim":58.0, @@ -744452,10 +747511,6 @@ "sim":57.0, "partner":"2otl" }, - { - "sim":57.0, - "partner":"3cd6" - }, { "sim":57.0, "partner":"1vqk" @@ -744625,16 +747680,16 @@ "partner":"1yjn" }, { - "sim":51.0, - "partner":"8fn2" + "sim":57.0, + "partner":"3cd6" }, { "sim":51.0, "partner":"8fmw" }, { - "sim":50.0, - "partner":"7m4x" + "sim":51.0, + "partner":"8fn2" }, { "sim":50.0, @@ -744714,7 +747769,7 @@ }, { "sim":50.0, - "partner":"6dzi" + "partner":"7m4x" }, { "sim":50.0, @@ -744726,11 +747781,11 @@ }, { "sim":50.0, - "partner":"5o60" + "partner":"6dzi" }, { "sim":50.0, - "partner":"8wi8" + "partner":"8v9l" }, { "sim":50.0, @@ -744740,25 +747795,17 @@ "sim":50.0, "partner":"5zet" }, - { - "sim":50.0, - "partner":"8v9l" - }, { "sim":50.0, "partner":"5zeb" }, - { - "sim":50.0, - "partner":"8why" - }, { "sim":50.0, "partner":"8v9k" }, { "sim":50.0, - "partner":"8wic" + "partner":"8wi8" }, { "sim":50.0, @@ -744774,7 +747821,11 @@ }, { "sim":50.0, - "partner":"8wi7" + "partner":"8why" + }, + { + "sim":50.0, + "partner":"8wic" }, { "sim":50.0, @@ -744782,7 +747833,7 @@ }, { "sim":50.0, - "partner":"8whx" + "partner":"8wi7" }, { "sim":50.0, @@ -744790,11 +747841,19 @@ }, { "sim":50.0, - "partner":"8wib" + "partner":"7y41" }, { "sim":50.0, - "partner":"7y41" + "partner":"8whx" + }, + { + "sim":50.0, + "partner":"5o60" + }, + { + "sim":50.0, + "partner":"8wib" } ], "struct_thr_sim_designed":[ @@ -744855,84 +747914,84 @@ ], "subtitle":"Crystal structure of the chimeric protein mkal2_v1", "tags":[ - "ob fold", - "ribosomal protein" + "ribosomal protein", + "ob fold" ], "keywords":[ - "predicted", - "beginning", - "early", - "evolution", - "designs", - "dpbbs", + "life", + "central", + "reconstructed", + "engineering", "molecular", - "many", - "results", - "proteins", - "ob", - "dna", - "similar", - "also", - "common", - "rna", - "although", - "similarities", "quickly", + "adopt", + "beginning", + "however", + "many", "conserved", - "topologies", - "polymerases", - "sh3", + "ob", + "metamorphic", + "indeed", + "indicate", + "diversified", + "biology", "named", - "machines", - "fold", - "means", + "simple", "modern", - "indeed", - "experiments", + "previously", "different", + "rna", + "dna", + "dogma", "remains", - "small", - "simple", - "found", - "ribosomal", - "reconstructed", - "folds", - "evolutionary", - "engineering", - "converted", "furthermore", - "central", - "ancient", - "transformed", - "drive", + "rift", + "structure", + "possess", + "fold", "discover", + "results", + "although", + "also", + "experiments", + "similarities", + "drive", + "transformed", + "means", + "protein", + "topologies", + "proteins", + "ribosomal", + "represented", + "dpbbs", + "enigmatic", + "emerged", + "ancient", "dpbb", + "sequence", + "predicted", + "early", + "small", + "distinct", + "common", + "machines", + "found", "numerous", - "life", - "dogma", - "possess", + "sh3", + "evolution", + "folds", "topologically", - "required", - "adopt", + "converted", "dzbb", - "enigmatic", - "protein", - "represented", + "ancestor", "shares", - "structure", + "designs", + "polymerases", "stage", - "rift", - "sequence", - "biology", - "emerged", - "indicate", - "distinct", + "required", + "similar", "could", - "ancestor", - "however", - "metamorphic", - "diversified", - "previously" + "evolutionary" ], "release_date":"2024-07-03", "publication":"\"An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins\", Nat Commun, 15, 5938-5938", @@ -745011,15 +748070,15 @@ }, { "sim":61.0, - "partner":"1ffk" + "partner":"1k8a" }, { "sim":61.0, - "partner":"1jj2" + "partner":"1ffk" }, { "sim":61.0, - "partner":"1k8a" + "partner":"1jj2" }, { "sim":61.0, @@ -745093,10 +748152,6 @@ "sim":61.0, "partner":"1kd1" }, - { - "sim":61.0, - "partner":"3cd6" - }, { "sim":61.0, "partner":"1vqk" @@ -745265,6 +748320,10 @@ "sim":61.0, "partner":"1yjn" }, + { + "sim":61.0, + "partner":"3cd6" + }, { "sim":59.0, "partner":"6th6" @@ -745279,19 +748338,19 @@ }, { "sim":56.0, - "partner":"4v6u" + "partner":"4v4n" }, { "sim":56.0, - "partner":"4v4n" + "partner":"4v6u" }, { "sim":50.0, - "partner":"8fn2" + "partner":"8fmw" }, { "sim":50.0, - "partner":"8fmw" + "partner":"8fn2" } ], "struct_thr_sim_designed":[ @@ -745355,84 +748414,84 @@ ], "subtitle":"Crystal structure of the chimeric protein tkol2_v1.2", "tags":[ - "ob fold", - "ribosomal protein" + "ribosomal protein", + "ob fold" ], "keywords":[ - "predicted", - "beginning", - "early", - "evolution", - "designs", - "dpbbs", + "life", + "central", + "reconstructed", + "engineering", "molecular", - "many", - "results", - "proteins", - "ob", - "dna", - "similar", - "also", - "common", - "rna", - "although", - "similarities", "quickly", + "adopt", + "beginning", + "however", + "many", "conserved", - "topologies", - "polymerases", - "sh3", + "ob", + "metamorphic", + "indeed", + "indicate", + "diversified", + "biology", "named", - "machines", - "fold", - "means", + "simple", "modern", - "indeed", - "experiments", + "previously", "different", + "rna", + "dna", + "dogma", "remains", - "small", - "simple", - "found", - "ribosomal", - "reconstructed", - "folds", - "evolutionary", - "engineering", - "converted", "furthermore", - "central", - "ancient", - "transformed", - "drive", + "rift", + "structure", + "possess", + "fold", "discover", + "results", + "although", + "also", + "experiments", + "similarities", + "drive", + "transformed", + "means", + "protein", + "topologies", + "proteins", + "ribosomal", + "represented", + "dpbbs", + "enigmatic", + "emerged", + "ancient", "dpbb", + "sequence", + "predicted", + "early", + "small", + "distinct", + "common", + "machines", + "found", "numerous", - "life", - "dogma", - "possess", + "sh3", + "evolution", + "folds", "topologically", - "required", - "adopt", + "converted", "dzbb", - "enigmatic", - "protein", - "represented", + "ancestor", "shares", - "structure", + "designs", + "polymerases", "stage", - "rift", - "sequence", - "biology", - "emerged", - "indicate", - "distinct", + "required", + "similar", "could", - "ancestor", - "however", - "metamorphic", - "diversified", - "previously" + "evolutionary" ], "release_date":"2024-07-03", "publication":"\"An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins\", Nat Commun, 15, 5938-5938", @@ -745497,11 +748556,11 @@ }, { "sim":51.0, - "partner":"8jvq" + "partner":"8jvr" }, { "sim":51.0, - "partner":"8jvr" + "partner":"8jvq" } ], "seq_thr_sim_natural":[ @@ -745519,11 +748578,11 @@ }, { "sim":62.0, - "partner":"4v6u" + "partner":"4v4n" }, { "sim":62.0, - "partner":"4v4n" + "partner":"4v6u" }, { "sim":52.0, @@ -745543,15 +748602,15 @@ }, { "sim":52.0, - "partner":"1ffk" + "partner":"1k8a" }, { "sim":52.0, - "partner":"1jj2" + "partner":"1ffk" }, { "sim":52.0, - "partner":"1k8a" + "partner":"1jj2" }, { "sim":52.0, @@ -745625,10 +748684,6 @@ "sim":52.0, "partner":"1kd1" }, - { - "sim":52.0, - "partner":"3cd6" - }, { "sim":52.0, "partner":"1vqk" @@ -745799,15 +748854,15 @@ }, { "sim":52.0, - "partner":"8fn2" + "partner":"3cd6" }, { "sim":52.0, "partner":"8fmw" }, { - "sim":50.0, - "partner":"7m4x" + "sim":52.0, + "partner":"8fn2" }, { "sim":50.0, @@ -745884,6 +748939,10 @@ { "sim":50.0, "partner":"7ryh" + }, + { + "sim":50.0, + "partner":"7m4x" } ], "struct_thr_sim_designed":[ @@ -745944,84 +749003,84 @@ ], "subtitle":"Crystal structure of the chimeric protein mkal2_v1.1", "tags":[ - "ob fold", - "ribosomal protein" + "ribosomal protein", + "ob fold" ], "keywords":[ - "predicted", - "beginning", - "early", - "evolution", - "designs", - "dpbbs", + "life", + "central", + "reconstructed", + "engineering", "molecular", - "many", - "results", - "proteins", - "ob", - "dna", - "similar", - "also", - "common", - "rna", - "although", - "similarities", "quickly", + "adopt", + "beginning", + "however", + "many", "conserved", - "topologies", - "polymerases", - "sh3", + "ob", + "metamorphic", + "indeed", + "indicate", + "diversified", + "biology", "named", - "machines", - "fold", - "means", + "simple", "modern", - "indeed", - "experiments", + "previously", "different", + "rna", + "dna", + "dogma", "remains", - "small", - "simple", - "found", - "ribosomal", - "reconstructed", - "folds", - "evolutionary", - "engineering", - "converted", "furthermore", - "central", - "ancient", - "transformed", - "drive", + "rift", + "structure", + "possess", + "fold", "discover", + "results", + "although", + "also", + "experiments", + "similarities", + "drive", + "transformed", + "means", + "protein", + "topologies", + "proteins", + "ribosomal", + "represented", + "dpbbs", + "enigmatic", + "emerged", + "ancient", "dpbb", + "sequence", + "predicted", + "early", + "small", + "distinct", + "common", + "machines", + "found", "numerous", - "life", - "dogma", - "possess", + "sh3", + "evolution", + "folds", "topologically", - "required", - "adopt", + "converted", "dzbb", - "enigmatic", - "protein", - "represented", + "ancestor", "shares", - "structure", + "designs", + "polymerases", "stage", - "rift", - "sequence", - "biology", - "emerged", - "indicate", - "distinct", + "required", + "similar", "could", - "ancestor", - "however", - "metamorphic", - "diversified", - "previously" + "evolutionary" ], "release_date":"2024-07-03", "publication":"\"An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins\", Nat Commun, 15, 5938-5938", @@ -746092,15 +749151,15 @@ }, { "sim":60.0, - "partner":"1ffk" + "partner":"1k8a" }, { "sim":60.0, - "partner":"1jj2" + "partner":"1ffk" }, { "sim":60.0, - "partner":"1k8a" + "partner":"1jj2" }, { "sim":60.0, @@ -746184,11 +749243,11 @@ }, { "sim":59.0, - "partner":"2otl" + "partner":"6th6" }, { "sim":59.0, - "partner":"6th6" + "partner":"2otl" }, { "sim":59.0, @@ -746198,10 +749257,6 @@ "sim":59.0, "partner":"6skg" }, - { - "sim":59.0, - "partner":"3cd6" - }, { "sim":59.0, "partner":"1vqk" @@ -746371,12 +749426,16 @@ "partner":"1yjn" }, { - "sim":56.0, - "partner":"4v6u" + "sim":59.0, + "partner":"3cd6" }, { "sim":56.0, "partner":"4v4n" + }, + { + "sim":56.0, + "partner":"4v6u" } ], "struct_thr_sim_designed":[ @@ -746444,80 +749503,80 @@ "double zeta beta barrel" ], "keywords":[ - "predicted", - "beginning", - "early", - "evolution", - "designs", - "dpbbs", + "life", + "central", + "reconstructed", + "engineering", "molecular", - "many", - "results", - "proteins", - "ob", - "dna", - "similar", - "also", - "common", - "rna", - "although", - "similarities", "quickly", + "adopt", + "beginning", + "however", + "many", "conserved", - "topologies", - "polymerases", - "sh3", + "ob", + "metamorphic", + "indeed", + "indicate", + "diversified", + "biology", "named", - "machines", - "fold", - "means", + "simple", "modern", - "indeed", - "experiments", + "previously", "different", + "rna", + "dna", + "dogma", "remains", - "small", - "simple", - "found", - "ribosomal", - "reconstructed", - "folds", - "evolutionary", - "engineering", - "converted", "furthermore", - "central", - "ancient", - "transformed", - "drive", + "rift", + "structure", + "possess", + "fold", "discover", + "results", + "although", + "also", + "experiments", + "similarities", + "drive", + "transformed", + "means", + "protein", + "topologies", + "proteins", + "ribosomal", + "represented", + "dpbbs", + "enigmatic", + "emerged", + "ancient", "dpbb", + "sequence", + "predicted", + "early", + "small", + "distinct", + "common", + "machines", + "found", "numerous", - "life", - "dogma", - "possess", + "sh3", + "evolution", + "folds", "topologically", - "required", - "adopt", + "converted", "dzbb", - "enigmatic", - "protein", - "represented", + "ancestor", "shares", - "structure", + "designs", + "polymerases", "stage", - "rift", - "sequence", - "biology", - "emerged", - "indicate", - "distinct", + "required", + "similar", "could", - "ancestor", - "however", - "metamorphic", - "diversified", - "previously" + "evolutionary" ], "release_date":"2024-07-03", "publication":"\"An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins\", Nat Commun, 15, 5938-5938", @@ -746612,15 +749671,15 @@ }, { "sim":55.0, - "partner":"7dxt" + "partner":"7dxw" }, { "sim":55.0, - "partner":"7dxw" + "partner":"7dxr" }, { "sim":55.0, - "partner":"7dxr" + "partner":"7dxt" }, { "sim":55.0, @@ -746689,80 +749748,80 @@ "double zeta beta barrel" ], "keywords":[ - "predicted", - "beginning", - "early", - "evolution", - "designs", - "dpbbs", + "life", + "central", + "reconstructed", + "engineering", "molecular", - "many", - "results", - "proteins", - "ob", - "dna", - "similar", - "also", - "common", - "rna", - "although", - "similarities", "quickly", + "adopt", + "beginning", + "however", + "many", "conserved", - "topologies", - "polymerases", - "sh3", + "ob", + "metamorphic", + "indeed", + "indicate", + "diversified", + "biology", "named", - "machines", - "fold", - "means", + "simple", "modern", - "indeed", - "experiments", + "previously", "different", + "rna", + "dna", + "dogma", "remains", - "small", - "simple", - "found", - "ribosomal", - "reconstructed", - "folds", - "evolutionary", - "engineering", - "converted", "furthermore", - "central", - "ancient", - "transformed", - "drive", + "rift", + "structure", + "possess", + "fold", "discover", + "results", + "although", + "also", + "experiments", + "similarities", + "drive", + "transformed", + "means", + "protein", + "topologies", + "proteins", + "ribosomal", + "represented", + "dpbbs", + "enigmatic", + "emerged", + "ancient", "dpbb", + "sequence", + "predicted", + "early", + "small", + "distinct", + "common", + "machines", + "found", "numerous", - "life", - "dogma", - "possess", + "sh3", + "evolution", + "folds", "topologically", - "required", - "adopt", + "converted", "dzbb", - "enigmatic", - "protein", - "represented", + "ancestor", "shares", - "structure", + "designs", + "polymerases", "stage", - "rift", - "sequence", - "biology", - "emerged", - "indicate", - "distinct", + "required", + "similar", "could", - "ancestor", - "however", - "metamorphic", - "diversified", - "previously" + "evolutionary" ], "release_date":"2024-07-03", "publication":"\"An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins\", Nat Commun, 15, 5938-5938", @@ -746815,11 +749874,11 @@ }, { "sim":59.0, - "partner":"8jvq" + "partner":"8jvr" }, { "sim":59.0, - "partner":"8jvr" + "partner":"8jvq" }, { "sim":56.0, @@ -746849,23 +749908,23 @@ }, { "sim":58.0, - "partner":"7dxu" + "partner":"7dxv" }, { "sim":58.0, - "partner":"7dxv" + "partner":"7dxu" }, { "sim":55.0, - "partner":"7dxt" + "partner":"7dxw" }, { "sim":55.0, - "partner":"7dxw" + "partner":"7dxr" }, { "sim":55.0, - "partner":"7dxr" + "partner":"7dxt" }, { "sim":55.0, @@ -746933,84 +749992,84 @@ ], "subtitle":"Crystal structure of the chimeric protein tkol2_v1_turn with shorten loop 1", "tags":[ - "ob fold", - "ribosomal protein" + "ribosomal protein", + "ob fold" ], "keywords":[ - "predicted", - "beginning", - "early", - "evolution", - "designs", - "dpbbs", + "life", + "central", + "reconstructed", + "engineering", "molecular", - "many", - "results", - "proteins", - "ob", - "dna", - "similar", - "also", - "common", - "rna", - "although", - "similarities", "quickly", + "adopt", + "beginning", + "however", + "many", "conserved", - "topologies", - "polymerases", - "sh3", + "ob", + "metamorphic", + "indeed", + "indicate", + "diversified", + "biology", "named", - "machines", - "fold", - "means", + "simple", "modern", - "indeed", - "experiments", + "previously", "different", + "rna", + "dna", + "dogma", "remains", - "small", - "simple", - "found", - "ribosomal", - "reconstructed", - "folds", - "evolutionary", - "engineering", - "converted", "furthermore", - "central", - "ancient", - "transformed", - "drive", + "rift", + "structure", + "possess", + "fold", "discover", + "results", + "although", + "also", + "experiments", + "similarities", + "drive", + "transformed", + "means", + "protein", + "topologies", + "proteins", + "ribosomal", + "represented", + "dpbbs", + "enigmatic", + "emerged", + "ancient", "dpbb", + "sequence", + "predicted", + "early", + "small", + "distinct", + "common", + "machines", + "found", "numerous", - "life", - "dogma", - "possess", + "sh3", + "evolution", + "folds", "topologically", - "required", - "adopt", + "converted", "dzbb", - "enigmatic", - "protein", - "represented", + "ancestor", "shares", - "structure", + "designs", + "polymerases", "stage", - "rift", - "sequence", - "biology", - "emerged", - "indicate", - "distinct", + "required", + "similar", "could", - "ancestor", - "however", - "metamorphic", - "diversified", - "previously" + "evolutionary" ], "release_date":"2024-07-03", "publication":"\"An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins\", Nat Commun, 15, 5938-5938", @@ -747127,84 +750186,84 @@ ], "subtitle":"Crystal structure of the circular-permutated protein mkal2_v1_sh3", "tags":[ - "sh3 fold", - "ribosomal protein" + "ribosomal protein", + "sh3 fold" ], "keywords":[ - "predicted", - "beginning", - "early", - "evolution", - "designs", - "dpbbs", + "life", + "central", + "reconstructed", + "engineering", "molecular", - "many", - "results", - "proteins", - "ob", - "dna", - "similar", - "also", - "common", - "rna", - "although", - "similarities", "quickly", + "adopt", + "beginning", + "however", + "many", "conserved", - "topologies", - "polymerases", - "sh3", + "ob", + "metamorphic", + "indeed", + "indicate", + "diversified", + "biology", "named", - "machines", - "fold", - "means", + "simple", "modern", - "indeed", - "experiments", + "previously", "different", + "rna", + "dna", + "dogma", "remains", - "small", - "simple", - "found", - "ribosomal", - "reconstructed", - "folds", - "evolutionary", - "engineering", - "converted", "furthermore", - "central", - "ancient", - "transformed", - "drive", + "rift", + "structure", + "possess", + "fold", "discover", + "results", + "although", + "also", + "experiments", + "similarities", + "drive", + "transformed", + "means", + "protein", + "topologies", + "proteins", + "ribosomal", + "represented", + "dpbbs", + "enigmatic", + "emerged", + "ancient", "dpbb", + "sequence", + "predicted", + "early", + "small", + "distinct", + "common", + "machines", + "found", "numerous", - "life", - "dogma", - "possess", + "sh3", + "evolution", + "folds", "topologically", - "required", - "adopt", + "converted", "dzbb", - "enigmatic", - "protein", - "represented", + "ancestor", "shares", - "structure", + "designs", + "polymerases", "stage", - "rift", - "sequence", - "biology", - "emerged", - "indicate", - "distinct", + "required", + "similar", "could", - "ancestor", - "however", - "metamorphic", - "diversified", - "previously" + "evolutionary" ], "release_date":"2024-07-03", "publication":"\"An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins\", Nat Commun, 15, 5938-5938", @@ -747237,11 +750296,11 @@ "seq_thr_sim_designed":[ { "sim":79.0, - "partner":"8jvt" + "partner":"8jvv" }, { "sim":79.0, - "partner":"8jvv" + "partner":"8jvt" }, { "sim":64.0, @@ -747259,15 +750318,15 @@ }, { "sim":53.0, - "partner":"1ffk" + "partner":"1k8a" }, { "sim":53.0, - "partner":"1jj2" + "partner":"1ffk" }, { "sim":53.0, - "partner":"1k8a" + "partner":"1jj2" }, { "sim":53.0, @@ -747353,10 +750412,6 @@ "sim":52.0, "partner":"2otl" }, - { - "sim":52.0, - "partner":"3cd6" - }, { "sim":52.0, "partner":"1vqk" @@ -747525,6 +750580,10 @@ "sim":52.0, "partner":"1yjn" }, + { + "sim":52.0, + "partner":"3cd6" + }, { "sim":51.0, "partner":"6th6" @@ -747546,7 +750605,7 @@ ], "seq_max_sim_designed":{ "sim":79.0, - "partner":"8jvt" + "partner":"8jvv" }, "seq_max_sim_natural":{ "sim":53.0, @@ -747596,9 +750655,9 @@ ], "subtitle":"Ancestral imine reducatase n560", "tags":[ - "imine reductase", + "de novo protein", "ancestral sequence reconstruction", - "de novo protein" + "imine reductase" ], "keywords":[ "description", @@ -747757,11 +750816,11 @@ }, { "sim":210.0, - "partner":"8ozw" + "partner":"8ozv" }, { "sim":210.0, - "partner":"8ozv" + "partner":"8ozw" }, { "sim":210.0, @@ -747827,6 +750886,10 @@ "sim":166.0, "partner":"8a3x" }, + { + "sim":150.0, + "partner":"8y12" + }, { "sim":141.0, "partner":"7a3w" @@ -747851,10 +750914,6 @@ "sim":64.0, "partner":"2uyy" }, - { - "sim":61.0, - "partner":"3ws7" - }, { "sim":61.0, "partner":"5xvh" @@ -747867,6 +750926,10 @@ "sim":61.0, "partner":"3w6z" }, + { + "sim":61.0, + "partner":"3ws7" + }, { "sim":58.0, "partner":"3pef" @@ -747958,8 +751021,8 @@ ], "subtitle":"De novo design protein -t01", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -748063,8 +751126,8 @@ ], "subtitle":"De novo design protein -t03", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -748167,8 +751230,8 @@ ], "subtitle":"De novo design protein -n1", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -748264,8 +751327,8 @@ ], "subtitle":"De novo design protein -n2", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -748361,8 +751424,8 @@ ], "subtitle":"De novo design protein -n3", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -748458,8 +751521,8 @@ ], "subtitle":"De novo design protein -n7", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -748562,8 +751625,8 @@ ], "subtitle":"De novo design protein -n9", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -748666,8 +751729,8 @@ ], "subtitle":"De novo design protein -n14", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -748763,8 +751826,8 @@ ], "subtitle":"De novo design protein -na7", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -748860,8 +751923,8 @@ ], "subtitle":"De novo design protein -nb7", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -748957,8 +752020,8 @@ ], "subtitle":"De novo design protein -nx1", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -749054,8 +752117,8 @@ ], "subtitle":"De novo design protein -nb8", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -749152,8 +752215,8 @@ ], "subtitle":"De novo design protein -nx5", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -749249,8 +752312,8 @@ ], "subtitle":"De novo design protein -na05", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -749346,8 +752409,8 @@ ], "subtitle":"De novo design protein -t09", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -749454,8 +752517,8 @@ ], "subtitle":"De novo design protein -t11", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -749552,8 +752615,8 @@ ], "subtitle":"De novo design protein -n7", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -749656,8 +752719,8 @@ ], "subtitle":"De novo design protein -n9", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -749760,8 +752823,8 @@ ], "subtitle":"De novo design protein -t03", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -749908,92 +752971,92 @@ ], "subtitle":"Structure of hyperstable haloalkane dehalogenase variant dhaa223", "tags":[ - "hydrolase", - "engineered haloalkane dehalogenase" + "engineered haloalkane dehalogenase", + "hydrolase" ], "keywords":[ - "compromised", - "thermostability", + "requirement", + "engineering", + "learning", + "show", "observe", - "use", - "bonds", + "machine", + "protein", + "study", + "manual", "improvement", - "still", - "including", - "prediction", - "mutations", - "potentially", - "current", - "local", - "improved", - "target", - "show", - "haloalkane", - "interactions", - "enhanced", - "designing", - "contacts", - "strategies", - "requirement", - "bioindustry", - "enzymes", - "compare", + "stabilization", + "essential", "yielding", - "tools", - "highly", - "strengthening", - "improving", - "better", - "destabilizing", "removal", - "structures", + "potentially", + "catalytic", + "stable", + "using", "introduction", - "essential", - "accompanied", - "revealed", - "achieved", - "rounds", - "previously", - "properties", + "guidance", + "due", + "automated", + "fireprot", + "disulfide", + "contacts", + "dhaa115", + "destabilizing", "stability", - "performance", - "dehalogenase", "large", - "catalytic", + "achieved", + "accuracy", + "rounds", + "use", + "enzymes", + "highly", + "saturation", + "computational", + "tools", + "including", + "local", + "designing", + "mutagenesis", "challenging", - "engineering", - "platforms", + "enhanced", + "current", + "accompanied", "provides", - "observed", - "comparison", + "platforms", + "different", + "compare", + "still", + "properties", + "dehalogenase", "applying", - "crystallographic", - "curation", - "using", + "bonds", + "prediction", + "performance", + "improved", + "backbone", + "pross", "notably", - "disulfide", - "learning", - "machine", - "accuracy", - "manual", - "saturation", - "stabilization", - "study", - "stable", - "different", + "strengthening", + "bioindustry", + "crystallographic", + "haloalkane", "reveal", + "revealed", + "strategies", + "mutations", + "observed", + "structures", + "improving", + "previously", + "curation", + "thermostability", "dehalogenases", - "fireprot", - "due", - "automated", - "dhaa115", - "protein", - "backbone", - "guidance", - "pross", - "computational", + "target", + "interactions", "silico", - "mutagenesis" + "compromised", + "better", + "comparison" ], "release_date":"2024-01-17", "publication":"\"Advancing Enzyme's Stability and Catalytic Efficiency through Synergy of Force-Field Calculations, Evolutionary Analysis, and Machine Learning\", Acs Catalysis, 13, 12506-12518", @@ -750080,15 +753143,15 @@ }, { "sim":604.0, - "partner":"3fwh" + "partner":"4hzg" }, { "sim":604.0, - "partner":"4hzg" + "partner":"4f5z" }, { "sim":604.0, - "partner":"4f5z" + "partner":"3fwh" }, { "sim":602.0, @@ -750216,31 +753279,31 @@ }, { "sim":552.0, - "partner":"7zix" + "partner":"6y7b" }, { "sim":552.0, - "partner":"7ziy" + "partner":"7zj0" }, { "sim":552.0, - "partner":"6y7a" + "partner":"8b6r" }, { "sim":552.0, - "partner":"7zj0" + "partner":"7ziw" }, { "sim":552.0, - "partner":"6y7b" + "partner":"7zix" }, { "sim":552.0, - "partner":"8b6r" + "partner":"7ziy" }, { "sim":552.0, - "partner":"7ziw" + "partner":"6y7a" }, { "sim":551.0, @@ -750264,19 +753327,19 @@ }, { "sim":549.0, - "partner":"7ziz" + "partner":"7ziv" }, { "sim":549.0, - "partner":"7ziv" + "partner":"7ziz" }, { "sim":548.0, - "partner":"6zvu" + "partner":"6zvv" }, { "sim":548.0, - "partner":"6zvv" + "partner":"6zvu" }, { "sim":546.0, @@ -750432,11 +753495,11 @@ }, { "sim":265.0, - "partner":"1iz8" + "partner":"1k63" }, { "sim":265.0, - "partner":"1k63" + "partner":"1iz8" }, { "sim":265.0, @@ -750448,15 +753511,15 @@ }, { "sim":265.0, - "partner":"7pw1" + "partner":"8b5o" }, { "sim":265.0, - "partner":"8b5o" + "partner":"1cv2" }, { "sim":265.0, - "partner":"1cv2" + "partner":"8b5k" }, { "sim":265.0, @@ -750472,15 +753535,15 @@ }, { "sim":265.0, - "partner":"8b5k" + "partner":"1g4h" }, { "sim":265.0, - "partner":"1g4h" + "partner":"1g42" }, { "sim":265.0, - "partner":"1g42" + "partner":"7pw1" }, { "sim":260.0, @@ -750582,22 +753645,10 @@ "sim":112.0, "partner":"1bee" }, - { - "sim":111.0, - "partner":"2dhc" - }, { "sim":111.0, "partner":"1hde" }, - { - "sim":111.0, - "partner":"2dhd" - }, - { - "sim":111.0, - "partner":"2dhe" - }, { "sim":111.0, "partner":"2had" @@ -750616,11 +753667,11 @@ }, { "sim":111.0, - "partner":"1cij" + "partner":"2yxp" }, { "sim":111.0, - "partner":"2yxp" + "partner":"1cij" }, { "sim":111.0, @@ -750638,10 +753689,22 @@ "sim":111.0, "partner":"1ede" }, + { + "sim":111.0, + "partner":"2dhc" + }, { "sim":111.0, "partner":"1be0" }, + { + "sim":111.0, + "partner":"2dhd" + }, + { + "sim":111.0, + "partner":"2dhe" + }, { "sim":109.0, "partner":"7avr" @@ -750666,14 +753729,6 @@ "sim":102.0, "partner":"8agn" }, - { - "sim":97.0, - "partner":"4y2x" - }, - { - "sim":97.0, - "partner":"4y2y" - }, { "sim":97.0, "partner":"4y2j" @@ -750751,8 +753806,12 @@ "partner":"4y2v" }, { - "sim":94.0, - "partner":"7p4k" + "sim":97.0, + "partner":"4y2x" + }, + { + "sim":97.0, + "partner":"4y2y" }, { "sim":94.0, @@ -750770,13 +753829,17 @@ "sim":94.0, "partner":"6yl4" }, + { + "sim":94.0, + "partner":"7a7g" + }, { "sim":94.0, "partner":"6fr2" }, { "sim":94.0, - "partner":"7a7g" + "partner":"7p4k" }, { "sim":91.0, @@ -750786,18 +753849,6 @@ "sim":91.0, "partner":"3pdc" }, - { - "sim":91.0, - "partner":"5ald" - }, - { - "sim":91.0, - "partner":"5ale" - }, - { - "sim":91.0, - "partner":"5alf" - }, { "sim":91.0, "partner":"5ake" @@ -751002,6 +754053,18 @@ "sim":91.0, "partner":"5ai6" }, + { + "sim":91.0, + "partner":"5ald" + }, + { + "sim":91.0, + "partner":"5ale" + }, + { + "sim":91.0, + "partner":"5alf" + }, { "sim":89.0, "partner":"4c4x" @@ -751042,10 +754105,6 @@ "sim":89.0, "partner":"6i5g" }, - { - "sim":89.0, - "partner":"6aum" - }, { "sim":89.0, "partner":"3i28" @@ -751102,6 +754161,10 @@ "sim":89.0, "partner":"1zd5" }, + { + "sim":89.0, + "partner":"6aum" + }, { "sim":88.0, "partner":"7ac0" @@ -751164,19 +754227,11 @@ }, { "sim":78.0, - "partner":"6qhu" - }, - { - "sim":78.0, - "partner":"6qhv" - }, - { - "sim":78.0, - "partner":"7a42" + "partner":"6gxt" }, { "sim":78.0, - "partner":"6qhw" + "partner":"6qhx" }, { "sim":78.0, @@ -751188,20 +754243,12 @@ }, { "sim":78.0, - "partner":"6gxt" - }, - { - "sim":78.0, - "partner":"6qhx" + "partner":"6qhy" }, { "sim":78.0, "partner":"3r3u" }, - { - "sim":78.0, - "partner":"6qhy" - }, { "sim":78.0, "partner":"6qhz" @@ -751210,17 +754257,13 @@ "sim":78.0, "partner":"6gxd" }, - { - "sim":78.0, - "partner":"5o2g" - }, { "sim":78.0, "partner":"6qi0" }, { "sim":78.0, - "partner":"5o2i" + "partner":"5o2g" }, { "sim":78.0, @@ -751232,12 +754275,16 @@ }, { "sim":78.0, - "partner":"5nyv" + "partner":"5o2i" }, { "sim":78.0, "partner":"6qi2" }, + { + "sim":78.0, + "partner":"5nyv" + }, { "sim":78.0, "partner":"6fsx" @@ -751248,11 +754295,11 @@ }, { "sim":78.0, - "partner":"3r3z" + "partner":"6gxh" }, { "sim":78.0, - "partner":"6gxh" + "partner":"3r3z" }, { "sim":78.0, @@ -751292,12 +754339,28 @@ }, { "sim":78.0, - "partner":"5y6y" + "partner":"6qhu" + }, + { + "sim":78.0, + "partner":"6qhv" + }, + { + "sim":78.0, + "partner":"7a42" + }, + { + "sim":78.0, + "partner":"6qhw" }, { "sim":78.0, "partner":"5yb5" }, + { + "sim":78.0, + "partner":"5y6y" + }, { "sim":78.0, "partner":"7cg6" @@ -751308,19 +754371,19 @@ }, { "sim":77.0, - "partner":"6qku" + "partner":"6qks" }, { "sim":77.0, - "partner":"6qkw" + "partner":"6qkt" }, { "sim":77.0, - "partner":"6qks" + "partner":"6qku" }, { "sim":77.0, - "partner":"6qkt" + "partner":"6qkw" }, { "sim":77.0, @@ -751334,10 +754397,6 @@ "sim":76.0, "partner":"5k3d" }, - { - "sim":76.0, - "partner":"5t4t" - }, { "sim":76.0, "partner":"5k3b" @@ -751364,15 +754423,15 @@ }, { "sim":76.0, - "partner":"7jqx" + "partner":"5t4t" }, { - "sim":75.0, - "partner":"1j1i" + "sim":76.0, + "partner":"7jqx" }, { "sim":75.0, - "partner":"5k3a" + "partner":"1j1i" }, { "sim":75.0, @@ -751386,6 +754445,10 @@ "sim":75.0, "partner":"3r41" }, + { + "sim":75.0, + "partner":"5k3a" + }, { "sim":74.0, "partner":"5swn" @@ -751534,14 +754597,6 @@ "sim":61.0, "partner":"4ccw" }, - { - "sim":61.0, - "partner":"3kd2" - }, - { - "sim":61.0, - "partner":"5hkb" - }, { "sim":61.0, "partner":"4dmf" @@ -751552,11 +754607,11 @@ }, { "sim":61.0, - "partner":"3pi6" + "partner":"8ee2" }, { "sim":61.0, - "partner":"8ee2" + "partner":"3pi6" }, { "sim":61.0, @@ -751564,11 +754619,11 @@ }, { "sim":61.0, - "partner":"4dmk" + "partner":"8eln" }, { "sim":61.0, - "partner":"8eln" + "partner":"4dmk" }, { "sim":61.0, @@ -751586,6 +754641,14 @@ "sim":61.0, "partner":"5hka" }, + { + "sim":61.0, + "partner":"3kd2" + }, + { + "sim":61.0, + "partner":"5hkb" + }, { "sim":60.0, "partner":"3fob" @@ -751682,10 +754745,6 @@ "sim":58.0, "partner":"3hi4" }, - { - "sim":58.0, - "partner":"4dln" - }, { "sim":58.0, "partner":"5tns" @@ -751695,12 +754754,12 @@ "partner":"4ehb" }, { - "sim":57.0, - "partner":"1u2e" + "sim":58.0, + "partner":"4dln" }, { "sim":57.0, - "partner":"4b9e" + "partner":"1u2e" }, { "sim":57.0, @@ -751723,8 +754782,8 @@ "partner":"4bau" }, { - "sim":56.0, - "partner":"4lyd" + "sim":57.0, + "partner":"4b9e" }, { "sim":56.0, @@ -751739,12 +754798,12 @@ "partner":"4lxi" }, { - "sim":55.0, - "partner":"4f0j" + "sim":56.0, + "partner":"4lyd" }, { "sim":55.0, - "partner":"4itv" + "partner":"4f0j" }, { "sim":55.0, @@ -751754,6 +754813,10 @@ "sim":55.0, "partner":"4iq4" }, + { + "sim":55.0, + "partner":"4itv" + }, { "sim":54.0, "partner":"4i3f" @@ -751770,10 +754833,6 @@ "sim":54.0, "partner":"4qes" }, - { - "sim":53.0, - "partner":"3t4u" - }, { "sim":53.0, "partner":"5egn" @@ -751786,6 +754845,10 @@ "sim":53.0, "partner":"3t52" }, + { + "sim":53.0, + "partner":"3t4u" + }, { "sim":53.0, "partner":"1a7u" @@ -752047,92 +755110,92 @@ ], "subtitle":"Structure of hyperstable haloalkane dehalogenase variant dhaa231", "tags":[ - "hydrolase", - "engineered haloalkane dehalogenase" + "engineered haloalkane dehalogenase", + "hydrolase" ], "keywords":[ - "compromised", - "thermostability", + "requirement", + "engineering", + "learning", + "show", "observe", - "use", - "bonds", + "machine", + "protein", + "study", + "manual", "improvement", - "still", - "including", - "prediction", - "mutations", - "potentially", - "current", - "local", - "improved", - "target", - "show", - "haloalkane", - "interactions", - "enhanced", - "designing", - "contacts", - "strategies", - "requirement", - "bioindustry", - "enzymes", - "compare", + "stabilization", + "essential", "yielding", - "tools", - "highly", - "strengthening", - "improving", - "better", - "destabilizing", "removal", - "structures", + "potentially", + "catalytic", + "stable", + "using", "introduction", - "essential", - "accompanied", - "revealed", - "achieved", - "rounds", - "previously", - "properties", + "guidance", + "due", + "automated", + "fireprot", + "disulfide", + "contacts", + "dhaa115", + "destabilizing", "stability", - "performance", - "dehalogenase", "large", - "catalytic", + "achieved", + "accuracy", + "rounds", + "use", + "enzymes", + "highly", + "saturation", + "computational", + "tools", + "including", + "local", + "designing", + "mutagenesis", "challenging", - "engineering", - "platforms", + "enhanced", + "current", + "accompanied", "provides", - "observed", - "comparison", + "platforms", + "different", + "compare", + "still", + "properties", + "dehalogenase", "applying", - "crystallographic", - "curation", - "using", + "bonds", + "prediction", + "performance", + "improved", + "backbone", + "pross", "notably", - "disulfide", - "learning", - "machine", - "accuracy", - "manual", - "saturation", - "stabilization", - "study", - "stable", - "different", + "strengthening", + "bioindustry", + "crystallographic", + "haloalkane", "reveal", + "revealed", + "strategies", + "mutations", + "observed", + "structures", + "improving", + "previously", + "curation", + "thermostability", "dehalogenases", - "fireprot", - "due", - "automated", - "dhaa115", - "protein", - "backbone", - "guidance", - "pross", - "computational", + "target", + "interactions", "silico", - "mutagenesis" + "compromised", + "better", + "comparison" ], "release_date":"2024-01-17", "publication":"\"Advancing Enzyme's Stability and Catalytic Efficiency through Synergy of Force-Field Calculations, Evolutionary Analysis, and Machine Learning\", Acs Catalysis, 13, 12506-12518", @@ -752347,31 +755410,31 @@ }, { "sim":532.0, - "partner":"7zix" + "partner":"6y7b" }, { "sim":532.0, - "partner":"7ziy" + "partner":"7zj0" }, { "sim":532.0, - "partner":"6y7a" + "partner":"8b6r" }, { "sim":532.0, - "partner":"7zj0" + "partner":"7ziw" }, { "sim":532.0, - "partner":"6y7b" + "partner":"7zix" }, { "sim":532.0, - "partner":"8b6r" + "partner":"7ziy" }, { "sim":532.0, - "partner":"7ziw" + "partner":"6y7a" }, { "sim":531.0, @@ -752379,11 +755442,11 @@ }, { "sim":531.0, - "partner":"7pcw" + "partner":"6zvw" }, { "sim":531.0, - "partner":"6zvw" + "partner":"7pcw" }, { "sim":531.0, @@ -752395,11 +755458,11 @@ }, { "sim":529.0, - "partner":"7ziz" + "partner":"7ziv" }, { "sim":529.0, - "partner":"7ziv" + "partner":"7ziz" }, { "sim":529.0, @@ -752407,11 +755470,11 @@ }, { "sim":528.0, - "partner":"6zvu" + "partner":"6zvv" }, { "sim":528.0, - "partner":"6zvv" + "partner":"6zvu" }, { "sim":527.0, @@ -752559,11 +755622,11 @@ }, { "sim":282.0, - "partner":"1iz8" + "partner":"1k63" }, { "sim":282.0, - "partner":"1k63" + "partner":"1iz8" }, { "sim":282.0, @@ -752713,18 +755776,6 @@ "sim":121.0, "partner":"4mj3" }, - { - "sim":111.0, - "partner":"2dhc" - }, - { - "sim":111.0, - "partner":"2dhd" - }, - { - "sim":111.0, - "partner":"2dhe" - }, { "sim":111.0, "partner":"2had" @@ -752743,15 +755794,15 @@ }, { "sim":111.0, - "partner":"1cij" + "partner":"2yxp" }, { "sim":111.0, - "partner":"1bez" + "partner":"1cij" }, { "sim":111.0, - "partner":"2yxp" + "partner":"1bez" }, { "sim":111.0, @@ -752773,17 +755824,21 @@ "sim":111.0, "partner":"1ede" }, + { + "sim":111.0, + "partner":"2dhc" + }, { "sim":111.0, "partner":"1be0" }, { "sim":111.0, - "partner":"4y2x" + "partner":"2dhd" }, { "sim":111.0, - "partner":"4y2y" + "partner":"2dhe" }, { "sim":111.0, @@ -752861,6 +755916,14 @@ "sim":111.0, "partner":"4y2v" }, + { + "sim":111.0, + "partner":"4y2x" + }, + { + "sim":111.0, + "partner":"4y2y" + }, { "sim":110.0, "partner":"1hde" @@ -752869,10 +755932,6 @@ "sim":108.0, "partner":"7avr" }, - { - "sim":108.0, - "partner":"7p4k" - }, { "sim":108.0, "partner":"6hgv" @@ -752889,13 +755948,17 @@ "sim":108.0, "partner":"6yl4" }, + { + "sim":108.0, + "partner":"7a7g" + }, { "sim":108.0, "partner":"6fr2" }, { "sim":108.0, - "partner":"7a7g" + "partner":"7p4k" }, { "sim":105.0, @@ -752905,18 +755968,6 @@ "sim":104.0, "partner":"3pdc" }, - { - "sim":104.0, - "partner":"5ald" - }, - { - "sim":104.0, - "partner":"5ale" - }, - { - "sim":104.0, - "partner":"5alf" - }, { "sim":104.0, "partner":"5ake" @@ -753121,6 +756172,18 @@ "sim":104.0, "partner":"5ai6" }, + { + "sim":104.0, + "partner":"5ald" + }, + { + "sim":104.0, + "partner":"5ale" + }, + { + "sim":104.0, + "partner":"5alf" + }, { "sim":103.0, "partner":"4c4x" @@ -753161,10 +756224,6 @@ "sim":103.0, "partner":"6i5g" }, - { - "sim":103.0, - "partner":"6aum" - }, { "sim":103.0, "partner":"3i28" @@ -753221,6 +756280,10 @@ "sim":103.0, "partner":"1zd5" }, + { + "sim":103.0, + "partner":"6aum" + }, { "sim":99.0, "partner":"8agp" @@ -753271,27 +756334,11 @@ }, { "sim":81.0, - "partner":"6qhu" - }, - { - "sim":81.0, - "partner":"6qku" - }, - { - "sim":81.0, - "partner":"6qhv" - }, - { - "sim":81.0, - "partner":"7a42" - }, - { - "sim":81.0, - "partner":"6qhw" + "partner":"6gxt" }, { "sim":81.0, - "partner":"6qkw" + "partner":"6qhx" }, { "sim":81.0, @@ -753303,20 +756350,12 @@ }, { "sim":81.0, - "partner":"6gxt" - }, - { - "sim":81.0, - "partner":"6qhx" + "partner":"6qhy" }, { "sim":81.0, "partner":"3r3u" }, - { - "sim":81.0, - "partner":"6qhy" - }, { "sim":81.0, "partner":"6qhz" @@ -753325,17 +756364,13 @@ "sim":81.0, "partner":"6gxd" }, - { - "sim":81.0, - "partner":"5o2g" - }, { "sim":81.0, "partner":"6qi0" }, { "sim":81.0, - "partner":"5o2i" + "partner":"5o2g" }, { "sim":81.0, @@ -753347,12 +756382,16 @@ }, { "sim":81.0, - "partner":"5nyv" + "partner":"5o2i" }, { "sim":81.0, "partner":"6qi2" }, + { + "sim":81.0, + "partner":"5nyv" + }, { "sim":81.0, "partner":"6fsx" @@ -753363,11 +756402,11 @@ }, { "sim":81.0, - "partner":"3r3z" + "partner":"6gxh" }, { "sim":81.0, - "partner":"6gxh" + "partner":"3r3z" }, { "sim":81.0, @@ -753413,6 +756452,30 @@ "sim":81.0, "partner":"6qkt" }, + { + "sim":81.0, + "partner":"6qhu" + }, + { + "sim":81.0, + "partner":"6qku" + }, + { + "sim":81.0, + "partner":"6qhv" + }, + { + "sim":81.0, + "partner":"7a42" + }, + { + "sim":81.0, + "partner":"6qhw" + }, + { + "sim":81.0, + "partner":"6qkw" + }, { "sim":81.0, "partner":"4nzz" @@ -753437,10 +756500,6 @@ "sim":79.0, "partner":"4io0" }, - { - "sim":79.0, - "partner":"5t4t" - }, { "sim":79.0, "partner":"5k3b" @@ -753467,15 +756526,15 @@ }, { "sim":79.0, - "partner":"7jqz" + "partner":"5t4t" }, { "sim":79.0, - "partner":"6unw" + "partner":"7jqz" }, { - "sim":78.0, - "partner":"5k3a" + "sim":79.0, + "partner":"6unw" }, { "sim":78.0, @@ -753489,6 +756548,10 @@ "sim":78.0, "partner":"3r41" }, + { + "sim":78.0, + "partner":"5k3a" + }, { "sim":77.0, "partner":"5swn" @@ -753535,15 +756598,15 @@ }, { "sim":75.0, - "partner":"5y6y" + "partner":"5y5d" }, { "sim":75.0, - "partner":"5y5d" + "partner":"5yb5" }, { "sim":75.0, - "partner":"5yb5" + "partner":"5y6y" }, { "sim":75.0, @@ -753669,14 +756732,6 @@ "sim":61.0, "partner":"3qyj" }, - { - "sim":61.0, - "partner":"3kd2" - }, - { - "sim":61.0, - "partner":"5hkb" - }, { "sim":61.0, "partner":"4dmf" @@ -753687,11 +756742,11 @@ }, { "sim":61.0, - "partner":"3pi6" + "partner":"8ee2" }, { "sim":61.0, - "partner":"8ee2" + "partner":"3pi6" }, { "sim":61.0, @@ -753699,11 +756754,11 @@ }, { "sim":61.0, - "partner":"4dmk" + "partner":"8eln" }, { "sim":61.0, - "partner":"8eln" + "partner":"4dmk" }, { "sim":61.0, @@ -753721,6 +756776,14 @@ "sim":61.0, "partner":"5hka" }, + { + "sim":61.0, + "partner":"3kd2" + }, + { + "sim":61.0, + "partner":"5hkb" + }, { "sim":61.0, "partner":"3b12" @@ -753811,15 +756874,15 @@ }, { "sim":58.0, - "partner":"4dln" + "partner":"5tns" }, { "sim":58.0, - "partner":"5tns" + "partner":"4ehb" }, { "sim":58.0, - "partner":"4ehb" + "partner":"4dln" }, { "sim":57.0, @@ -753843,23 +756906,23 @@ }, { "sim":57.0, - "partner":"7zm2" + "partner":"7zm4" }, { "sim":57.0, - "partner":"7zm3" + "partner":"7zm1" }, { "sim":57.0, - "partner":"7zm4" + "partner":"7zjt" }, { "sim":57.0, - "partner":"7zm1" + "partner":"7zm2" }, { "sim":57.0, - "partner":"7zjt" + "partner":"7zm3" }, { "sim":55.0, @@ -753869,10 +756932,6 @@ "sim":55.0, "partner":"3hea" }, - { - "sim":55.0, - "partner":"4lyd" - }, { "sim":55.0, "partner":"4lye" @@ -753887,7 +756946,7 @@ }, { "sim":55.0, - "partner":"4b9e" + "partner":"4lyd" }, { "sim":55.0, @@ -753909,6 +756968,10 @@ "sim":55.0, "partner":"4bau" }, + { + "sim":55.0, + "partner":"4b9e" + }, { "sim":54.0, "partner":"5egn" @@ -753919,15 +756982,15 @@ }, { "sim":54.0, - "partner":"4itv" + "partner":"4ivj" }, { "sim":54.0, - "partner":"4ivj" + "partner":"4iq4" }, { "sim":54.0, - "partner":"4iq4" + "partner":"4itv" }, { "sim":53.0, @@ -753999,11 +757062,11 @@ }, { "sim":50.0, - "partner":"3t4u" + "partner":"3t52" }, { "sim":50.0, - "partner":"3t52" + "partner":"3t4u" }, { "sim":50.0, @@ -754242,114 +757305,114 @@ ], "subtitle":"Structure of the tau-pam4 type 1 amyloid fibril", "tags":[ - "neurodegeneration", "cross-beta", - "fibril", - "amyloid", + "tau", "helical", + "fibril", "protein fibril", - "tau" + "neurodegeneration", + "amyloid" ], "keywords":[ - "encompass", - "analysis", - "palsy", - "results", - "propensity", - "contributions", - "pathologic", - "propagating", - "peptide", - "polymorphs", - "polymorph", - "polymorphic", - "underscoring", - "determine", - "alzheimer", - "synthetic", - "structure", - "repeat", - "however", - "tendencies", - "alternative", - "neurodegenerative", - "disease", - "consistent", - "intrinsic", - "fibril", "calculation", - "corticobasal", - "integrity", - "contributor", - "dictate", - "amyloidogenic", - "persistence", - "remains", - "suggests", - "motif", - "furthermore", - "preserving", - "extracted", - "highlight", - "efficiency", - "structures", - "pivotal", - "cellular", - "revealed", - "shows", + "disease", "role", - "contribute", - "pathological", - "degeneration", - "stability", - "plays", - "supranuclear", - "hampers", - "conditions", - "tau", + "structural", + "repeat", + "characterised", + "experimental", + "amyloidogenic", "group", - "extent", - "identify", - "patients", - "4", - "approaches", - "closely", - "deletion", - "polymorphism", - "progressive", "core", - "using", - "across", - "segments", - "sequence", + "pathological", + "results", + "disorders", + "new", "adopted", + "integrity", + "polymorphism", + "across", + "seeding", + "motif", + "polymorphs", + "cellular", + "together", "cells", - "structural", + "intrinsic", "aggregates", - "diverse", + "using", + "alternative", + "shows", + "however", + "hampers", + "formed", + "supranuclear", + "preserving", + "furthermore", + "alzheimer", + "extracted", + "progressive", + "strains", + "stability", + "propensity", + "corticobasal", + "adopts", + "tauopathies", + "extent", + "fibril", + "neurodegenerative", "importance", - "disorders", - "pam4", - "experimental", + "combination", + "peptide", + "polymorph", + "contributor", + "degeneration", + "highlight", + "diverse", + "suggests", + "tau", + "polymorphic", + "different", "experiments", + "propagating", + "underscoring", + "persistence", + "deletion", + "pam4", "fibrils", - "together", - "different", - "tauopathies", + "uncertain", + "conditions", + "correspond", + "segments", + "dictate", + "sequence", + "determine", + "contributions", "central", + "analysis", + "revealed", + "encompass", + "structures", + "approaches", + "contribute", + "remains", + "structure", + "synthetic", + "closely", + "plays", + "pathologic", + "4", + "tendencies", + "identify", "amyloid", - "cores", - "uncertain", "significant", - "adopts", - "characterised", - "seeding", - "combination", + "patients", "distinct", - "strains", - "formed", - "correspond", - "new" + "cores", + "efficiency", + "palsy", + "pivotal", + "consistent" ], "release_date":"2024-02-21", "publication":"\"Local structural preferences in shaping tau amyloid polymorphism\", Nat Commun, 15, 1028-1028", @@ -754499,115 +757562,115 @@ ], "subtitle":"Structure of the fmoc-tau-pam4 type 2 amyloid fibril", "tags":[ - "neurodegeneration", "cross-beta", + "tau", + "helical", "fibril", "fmoc", - "amyloid", - "helical", "protein fibril", - "tau" + "neurodegeneration", + "amyloid" ], "keywords":[ - "encompass", - "analysis", - "palsy", - "results", - "propensity", - "contributions", - "pathologic", - "propagating", - "peptide", - "polymorphs", - "polymorph", - "polymorphic", - "underscoring", - "determine", - "alzheimer", - "synthetic", - "structure", - "repeat", - "however", - "tendencies", - "alternative", - "neurodegenerative", - "disease", - "consistent", - "intrinsic", - "fibril", "calculation", - "corticobasal", - "integrity", - "contributor", - "dictate", - "amyloidogenic", - "persistence", - "remains", - "suggests", - "motif", - "furthermore", - "preserving", - "extracted", - "highlight", - "efficiency", - "structures", - "pivotal", - "cellular", - "revealed", - "shows", + "disease", "role", - "contribute", - "pathological", - "degeneration", - "stability", - "plays", - "supranuclear", - "hampers", - "conditions", - "tau", + "structural", + "repeat", + "characterised", + "experimental", + "amyloidogenic", "group", - "extent", - "identify", - "patients", - "4", - "approaches", - "closely", - "deletion", - "polymorphism", - "progressive", "core", - "using", - "across", - "segments", - "sequence", + "pathological", + "results", + "disorders", + "new", "adopted", + "integrity", + "polymorphism", + "across", + "seeding", + "motif", + "polymorphs", + "cellular", + "together", "cells", - "structural", + "intrinsic", "aggregates", - "diverse", + "using", + "alternative", + "shows", + "however", + "hampers", + "formed", + "supranuclear", + "preserving", + "furthermore", + "alzheimer", + "extracted", + "progressive", + "strains", + "stability", + "propensity", + "corticobasal", + "adopts", + "tauopathies", + "extent", + "fibril", + "neurodegenerative", "importance", - "disorders", - "pam4", - "experimental", + "combination", + "peptide", + "polymorph", + "contributor", + "degeneration", + "highlight", + "diverse", + "suggests", + "tau", + "polymorphic", + "different", "experiments", + "propagating", + "underscoring", + "persistence", + "deletion", + "pam4", "fibrils", - "together", - "different", - "tauopathies", + "uncertain", + "conditions", + "correspond", + "segments", + "dictate", + "sequence", + "determine", + "contributions", "central", + "analysis", + "revealed", + "encompass", + "structures", + "approaches", + "contribute", + "remains", + "structure", + "synthetic", + "closely", + "plays", + "pathologic", + "4", + "tendencies", + "identify", "amyloid", - "cores", - "uncertain", "significant", - "adopts", - "characterised", - "seeding", - "combination", + "patients", "distinct", - "strains", - "formed", - "correspond", - "new" + "cores", + "efficiency", + "palsy", + "pivotal", + "consistent" ], "release_date":"2024-02-21", "publication":"\"Local structural preferences in shaping tau amyloid polymorphism\", Nat Commun, 15, 1028-1028", @@ -754757,115 +757820,115 @@ ], "subtitle":"Structure of the fmoc-tau-pam4 type 3 amyloid fibril", "tags":[ - "neurodegeneration", "cross-beta", + "tau", + "helical", "fibril", "fmoc", - "amyloid", - "helical", "protein fibril", - "tau" + "neurodegeneration", + "amyloid" ], "keywords":[ - "encompass", - "analysis", - "palsy", - "results", - "propensity", - "contributions", - "pathologic", - "propagating", - "peptide", - "polymorphs", - "polymorph", - "polymorphic", - "underscoring", - "determine", - "alzheimer", - "synthetic", - "structure", - "repeat", - "however", - "tendencies", - "alternative", - "neurodegenerative", - "disease", - "consistent", - "intrinsic", - "fibril", "calculation", - "corticobasal", - "integrity", - "contributor", - "dictate", - "amyloidogenic", - "persistence", - "remains", - "suggests", - "motif", - "furthermore", - "preserving", - "extracted", - "highlight", - "efficiency", - "structures", - "pivotal", - "cellular", - "revealed", - "shows", + "disease", "role", - "contribute", - "pathological", - "degeneration", - "stability", - "plays", - "supranuclear", - "hampers", - "conditions", - "tau", + "structural", + "repeat", + "characterised", + "experimental", + "amyloidogenic", "group", - "extent", - "identify", - "patients", - "4", - "approaches", - "closely", - "deletion", - "polymorphism", - "progressive", "core", - "using", - "across", - "segments", - "sequence", + "pathological", + "results", + "disorders", + "new", "adopted", + "integrity", + "polymorphism", + "across", + "seeding", + "motif", + "polymorphs", + "cellular", + "together", "cells", - "structural", + "intrinsic", "aggregates", - "diverse", + "using", + "alternative", + "shows", + "however", + "hampers", + "formed", + "supranuclear", + "preserving", + "furthermore", + "alzheimer", + "extracted", + "progressive", + "strains", + "stability", + "propensity", + "corticobasal", + "adopts", + "tauopathies", + "extent", + "fibril", + "neurodegenerative", "importance", - "disorders", - "pam4", - "experimental", + "combination", + "peptide", + "polymorph", + "contributor", + "degeneration", + "highlight", + "diverse", + "suggests", + "tau", + "polymorphic", + "different", "experiments", + "propagating", + "underscoring", + "persistence", + "deletion", + "pam4", "fibrils", - "together", - "different", - "tauopathies", + "uncertain", + "conditions", + "correspond", + "segments", + "dictate", + "sequence", + "determine", + "contributions", "central", + "analysis", + "revealed", + "encompass", + "structures", + "approaches", + "contribute", + "remains", + "structure", + "synthetic", + "closely", + "plays", + "pathologic", + "4", + "tendencies", + "identify", "amyloid", - "cores", - "uncertain", "significant", - "adopts", - "characterised", - "seeding", - "combination", + "patients", "distinct", - "strains", - "formed", - "correspond", - "new" + "cores", + "efficiency", + "palsy", + "pivotal", + "consistent" ], "release_date":"2024-02-21", "publication":"\"Local structural preferences in shaping tau amyloid polymorphism\", Nat Commun, 15, 1028-1028", @@ -755015,115 +758078,115 @@ ], "subtitle":"Structure of the fmoc-tau-pam4 type 4 amyloid fibril", "tags":[ - "neurodegeneration", "cross-beta", + "tau", + "helical", "fibril", "fmoc", - "amyloid", - "helical", "protein fibril", - "tau" + "neurodegeneration", + "amyloid" ], "keywords":[ - "encompass", - "analysis", - "palsy", - "results", - "propensity", - "contributions", - "pathologic", - "propagating", - "peptide", - "polymorphs", - "polymorph", - "polymorphic", - "underscoring", - "determine", - "alzheimer", - "synthetic", - "structure", - "repeat", - "however", - "tendencies", - "alternative", - "neurodegenerative", - "disease", - "consistent", - "intrinsic", - "fibril", "calculation", - "corticobasal", - "integrity", - "contributor", - "dictate", - "amyloidogenic", - "persistence", - "remains", - "suggests", - "motif", - "furthermore", - "preserving", - "extracted", - "highlight", - "efficiency", - "structures", - "pivotal", - "cellular", - "revealed", - "shows", + "disease", "role", - "contribute", - "pathological", - "degeneration", - "stability", - "plays", - "supranuclear", - "hampers", - "conditions", - "tau", + "structural", + "repeat", + "characterised", + "experimental", + "amyloidogenic", "group", - "extent", - "identify", - "patients", - "4", - "approaches", - "closely", - "deletion", - "polymorphism", - "progressive", "core", - "using", - "across", - "segments", - "sequence", + "pathological", + "results", + "disorders", + "new", "adopted", + "integrity", + "polymorphism", + "across", + "seeding", + "motif", + "polymorphs", + "cellular", + "together", "cells", - "structural", + "intrinsic", "aggregates", - "diverse", + "using", + "alternative", + "shows", + "however", + "hampers", + "formed", + "supranuclear", + "preserving", + "furthermore", + "alzheimer", + "extracted", + "progressive", + "strains", + "stability", + "propensity", + "corticobasal", + "adopts", + "tauopathies", + "extent", + "fibril", + "neurodegenerative", "importance", - "disorders", - "pam4", - "experimental", + "combination", + "peptide", + "polymorph", + "contributor", + "degeneration", + "highlight", + "diverse", + "suggests", + "tau", + "polymorphic", + "different", "experiments", + "propagating", + "underscoring", + "persistence", + "deletion", + "pam4", "fibrils", - "together", - "different", - "tauopathies", + "uncertain", + "conditions", + "correspond", + "segments", + "dictate", + "sequence", + "determine", + "contributions", "central", + "analysis", + "revealed", + "encompass", + "structures", + "approaches", + "contribute", + "remains", + "structure", + "synthetic", + "closely", + "plays", + "pathologic", + "4", + "tendencies", + "identify", "amyloid", - "cores", - "uncertain", "significant", - "adopts", - "characterised", - "seeding", - "combination", + "patients", "distinct", - "strains", - "formed", - "correspond", - "new" + "cores", + "efficiency", + "palsy", + "pivotal", + "consistent" ], "release_date":"2024-02-21", "publication":"\"Local structural preferences in shaping tau amyloid polymorphism\", Nat Commun, 15, 1028-1028", @@ -755245,81 +758308,81 @@ "protein fibril" ], "keywords":[ - "derivatives", - "progresses", + "readopt", + "evolutionarily", "glucagon", - "aggregation", "bloodstream", + "progresses", + "highlight", + "ftir", + "aprs", "exendin", - "acidic", - "functional", - "afm", - "monomeric", - "large", - "results", + "role", + "conserved", "protonation", - "gastrointestinal", - "reversible", + "structures", + "functional", + "absence", "group", - "changes", - "family", - "gatekeepers", - "conserved", - "xfxxwl", - "fibrils", - "identify", - "peptides", - "apr", - "stored", "polymorphic", - "1", - "cd", - "receptor", - "determine", + "core", + "secretion", + "derivatives", "residues", + "sensitivity", + "acidic", + "monomeric", + "family", + "nine", "assays", + "results", "short", - "broad", - "readopt", - "region", - "switching", - "absence", - "sensitivity", - "crystal", + "afm", + "aggregation", + "dual", + "reversible", + "cd", + "gatekeepers", "state", - "folded", - "find", + "propose", "vesicles", - "hexapeptide", - "highlight", - "core", + "hormones", + "folded", "follow", - "amyloid", - "structures", - "secretion", - "ftir", + "gastrointestinal", + "ph", + "hexapeptide", + "large", + "binding", + "fibrils", + "changes", + "formation", + "switching", + "broad", + "find", + "identify", "2", - "states", - "propose", - "dual", "segments", - "diminishes", - "sequence", - "motifs", - "nine", - "aprs", - "released", - "formation", - "hormones", + "amyloid", "tht", - "ph", - "major", + "sequence", + "states", "initiate", - "role", - "binding", - "evolutionarily", + "peptides", + "stored", "forms", - "range" + "major", + "diminishes", + "motifs", + "xfxxwl", + "region", + "crystal", + "apr", + "determine", + "range", + "1", + "receptor", + "released" ], "release_date":"2023-08-02", "publication":"\"Polymorphic amyloid nanostructures of hormone peptides involved in glucose homeostasis display reversible amyloid formation\", Nat Commun, 14, 4621-4621", @@ -755421,86 +758484,86 @@ ], "subtitle":"Crystal structure of an 8-repeat consensus tpr superhelix with barium", "tags":[ - "metal coordination", - "ctpr", + "polymorphism", "de novo protein", - "polymorphism" + "metal coordination", + "ctpr" ], "keywords":[ - "facile", + "form", + "crystalline", + "engineering", + "calculations", + "pofs", + "allow", + "controlled", + "responsible", + "presents", + "metal", + "negatively", + "opening", + "exposed", + "thermodynamically", + "repeat", "diverse", - "scope", - "obtained", - "density", - "despite", + "comparison", + "structurally", + "requirements", "salts", - "amino", - "proteins", + "single", + "porosity", "functional", - "frameworks", + "kinetically", + "polymorphic", "thus", - "coordination", - "presents", - "assemblies", - "pofs", - "strategy", - "single", - "stable", - "metal", - "cluster", - "calculations", - "opening", - "scaffolds", + "application", + "residues", + "preferences", + "controllable", "acid", - "negatively", - "polymorphs", - "trapped", + "scaffolds", + "addition", "finding", - "controlled", - "polymorphic", - "allow", - "residues", - "abundance", - "tetratricopeptide", + "diversity", + "strategy", + "new", + "frameworks", + "ion", + "protein", + "trapped", + "polymorphism", + "amino", "exploiting", - "direct", - "crystal", - "engineering", - "geometric", + "proteins", + "tetratricopeptide", + "achieved", + "cluster", + "polymorphs", "innate", - "kinetically", - "application", - "addition", - "polymorphism", - "increasingly", - "comparison", - "protein", - "controllable", - "biocompatible", - "applications", - "states", - "requirements", - "negative", - "charged", - "theory", - "structurally", - "responsible", - "repeat", "showed", - "diversity", - "thermodynamically", - "minimal", "varying", - "crystalline", - "form", - "porosity", - "achieved", - "preferences", - "exposed", + "direct", "consensus", + "coordination", + "charged", + "biocompatible", + "negative", + "states", + "scope", "crystals", - "ion", - "new" + "increasingly", + "density", + "despite", + "applications", + "crystal", + "stable", + "theory", + "assemblies", + "minimal", + "abundance", + "obtained", + "geometric", + "facile" ], "release_date":"2024-04-24", "publication":"\"Diverse crystalline protein scaffolds through metal-dependent polymorphism\", Protein Sci., 33, e4971-e4971", @@ -755533,35 +758596,35 @@ "seq_thr_sim_designed":[ { "sim":622.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":622.0, - "partner":"8cqq" + "partner":"8cqp" }, { "sim":622.0, - "partner":"8chy" + "partner":"8cmq" }, { "sim":622.0, - "partner":"8cmq" + "partner":"8bu0" }, { "sim":622.0, - "partner":"8ckr" + "partner":"8cp8" }, { "sim":622.0, - "partner":"8cig" + "partner":"8cqq" }, { "sim":622.0, - "partner":"8cqp" + "partner":"8chy" }, { "sim":622.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":303.0, @@ -755601,11 +758664,11 @@ }, { "sim":136.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":136.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":127.0, @@ -755621,15 +758684,15 @@ }, { "sim":94.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":94.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":94.0, - "partner":"8cus" + "partner":"8cwz" } ], "seq_thr_sim_natural":[ @@ -755661,10 +758724,6 @@ "sim":178.0, "partner":"7y4i" }, - { - "sim":178.0, - "partner":"8dtf" - }, { "sim":178.0, "partner":"8dtg" @@ -755677,6 +758736,10 @@ "sim":178.0, "partner":"8dti" }, + { + "sim":178.0, + "partner":"8dtf" + }, { "sim":164.0, "partner":"8ur5" @@ -755723,23 +758786,23 @@ }, { "sim":139.0, - "partner":"7ep7" + "partner":"4g2v" }, { "sim":139.0, - "partner":"4g2v" + "partner":"7ep7" }, { "sim":138.0, - "partner":"8a5y" + "partner":"8a3t" }, { "sim":138.0, - "partner":"8a3t" + "partner":"8a61" }, { "sim":138.0, - "partner":"8a61" + "partner":"8a5y" }, { "sim":136.0, @@ -755753,10 +758816,6 @@ "sim":131.0, "partner":"6xt9" }, - { - "sim":130.0, - "partner":"4rg6" - }, { "sim":130.0, "partner":"4rg7" @@ -755767,11 +758826,7 @@ }, { "sim":130.0, - "partner":"5lcw" - }, - { - "sim":130.0, - "partner":"6q6g" + "partner":"4rg6" }, { "sim":130.0, @@ -755795,16 +758850,12 @@ }, { "sim":130.0, - "partner":"8pkp" + "partner":"6tlj" }, { "sim":130.0, "partner":"5l9u" }, - { - "sim":130.0, - "partner":"6tlj" - }, { "sim":130.0, "partner":"6q6h" @@ -755817,6 +758868,10 @@ "sim":130.0, "partner":"5a31" }, + { + "sim":130.0, + "partner":"8pkp" + }, { "sim":130.0, "partner":"5g05" @@ -755829,25 +758884,33 @@ "sim":130.0, "partner":"4ui9" }, + { + "sim":130.0, + "partner":"6q6g" + }, { "sim":130.0, "partner":"8tau" }, + { + "sim":130.0, + "partner":"5lcw" + }, { "sim":125.0, - "partner":"6voa" + "partner":"6vbu" }, { "sim":125.0, - "partner":"6vnw" + "partner":"6vbv" }, { "sim":125.0, - "partner":"6vbu" + "partner":"6voa" }, { "sim":125.0, - "partner":"6vbv" + "partner":"6vnw" }, { "sim":122.0, @@ -755873,22 +758936,6 @@ "sim":107.0, "partner":"6tka" }, - { - "sim":106.0, - "partner":"4xif" - }, - { - "sim":106.0, - "partner":"8fe7" - }, - { - "sim":106.0, - "partner":"4gyw" - }, - { - "sim":106.0, - "partner":"5vif" - }, { "sim":106.0, "partner":"4xi9" @@ -755929,6 +758976,10 @@ "sim":106.0, "partner":"5c1d" }, + { + "sim":106.0, + "partner":"6ma1" + }, { "sim":106.0, "partner":"3pe4" @@ -755951,15 +759002,15 @@ }, { "sim":106.0, - "partner":"6ma1" + "partner":"6ma2" }, { "sim":106.0, - "partner":"4n3c" + "partner":"8fe6" }, { "sim":106.0, - "partner":"6ma2" + "partner":"4n3c" }, { "sim":106.0, @@ -755967,7 +759018,7 @@ }, { "sim":106.0, - "partner":"8fe6" + "partner":"8fuf" }, { "sim":106.0, @@ -755979,7 +759030,11 @@ }, { "sim":106.0, - "partner":"8fuf" + "partner":"8cm9" + }, + { + "sim":106.0, + "partner":"6ma5" }, { "sim":106.0, @@ -755987,11 +759042,15 @@ }, { "sim":106.0, - "partner":"8cm9" + "partner":"8fe7" }, { "sim":106.0, - "partner":"6ma5" + "partner":"6ibo" + }, + { + "sim":106.0, + "partner":"6q4m" }, { "sim":106.0, @@ -755999,11 +759058,15 @@ }, { "sim":106.0, - "partner":"6ibo" + "partner":"4xif" }, { "sim":106.0, - "partner":"6q4m" + "partner":"4gyw" + }, + { + "sim":106.0, + "partner":"5vif" }, { "sim":105.0, @@ -756061,10 +759124,6 @@ "sim":87.0, "partner":"2c0m" }, - { - "sim":87.0, - "partner":"4kyo" - }, { "sim":87.0, "partner":"3r9a" @@ -756077,6 +759136,10 @@ "sim":87.0, "partner":"4kxk" }, + { + "sim":87.0, + "partner":"4kyo" + }, { "sim":87.0, "partner":"1fch" @@ -756283,11 +759346,11 @@ }, { "sim":70.0, - "partner":"5w5i" + "partner":"5w5h" }, { "sim":70.0, - "partner":"5w5h" + "partner":"5w5i" }, { "sim":69.0, @@ -756351,11 +759414,11 @@ }, { "sim":59.0, - "partner":"7qws" + "partner":"6t59" }, { "sim":59.0, - "partner":"6t59" + "partner":"7qws" }, { "sim":59.0, @@ -756411,11 +759474,11 @@ }, { "sim":58.0, - "partner":"4i9e" + "partner":"3ulq" }, { "sim":58.0, - "partner":"3ulq" + "partner":"4i9e" }, { "sim":57.0, @@ -756535,11 +759598,11 @@ }, { "sim":55.0, - "partner":"8hmc" + "partner":"8hmd" }, { "sim":55.0, - "partner":"8hmd" + "partner":"8hmc" }, { "sim":54.0, @@ -756603,11 +759666,11 @@ }, { "sim":52.0, - "partner":"6fdp" + "partner":"6fdt" }, { "sim":52.0, - "partner":"6fdt" + "partner":"6fdp" }, { "sim":52.0, @@ -756650,7 +759713,7 @@ ], "seq_max_sim_designed":{ "sim":622.0, - "partner":"8bu0" + "partner":"8ckr" }, "seq_max_sim_natural":{ "sim":233.0, @@ -756757,82 +759820,82 @@ ], "subtitle":"De novo designed tim barrel fold tbf_24", "tags":[ + "tim barrel", "de novo protein", - "de novo designed", - "tim barrel" + "de novo designed" ], "keywords":[ - "accuracy", - "stability", - "biophysical", - "thermal", - "enabling", - "demonstrate", - "expansion", - "designs", - "proteome", - "functional", - "membrane", - "proteins", - "analyses", + "designed", + "complex", + "design", + "space", + "learning", + "structural", "receptors", - "unique", - "use", - "remarkable", - "substantial", + "show", + "rates", + "soluble", "de", - "novo", - "success", - "challenge", - "topologies", "experimental", - "drug", + "structures", + "functional", + "integral", + "approaches", + "enabling", "recapitulated", - "fold", - "means", - "1", - "discovery", - "designed", - "facto", "remains", - "functionalized", - "approaches", - "functions", - "robust", - "found", - "potentially", - "folds", - "leading", - "features", - "show", - "design", "enriched", "concept", - "structures", + "facto", + "bringing", + "fold", + "new", + "pipeline", + "functions", + "thermal", + "means", "protein", - "soluble", - "using", - "2", - "complex", - "space", - "analogues", + "solely", + "topologies", + "biophysical", + "stability", + "membrane", + "proteome", + "drug", + "proteins", + "remarkable", "solution", + "leading", + "analogues", + "accuracy", + "use", + "2", + "functionalities", + "novo", "high", - "bringing", + "demonstrate", "native", - "motifs", - "computational", - "solely", + "success", "proof", - "functionalities", - "deep", + "found", + "motifs", + "potentially", + "discovery", + "functionalized", "summary", - "learning", - "rates", - "structural", - "pipeline", - "integral", - "new" + "unique", + "features", + "analyses", + "challenge", + "designs", + "expansion", + "computational", + "substantial", + "using", + "folds", + "1", + "robust", + "deep" ], "release_date":"2023-10-18", "publication":"\"Computational design of soluble and functional membrane protein analogues\", Nature, 631, 449-458", @@ -756982,83 +760045,83 @@ ], "subtitle":"De novo designed claudin fold clf_4", "tags":[ - "claudin", "de novo protein", "de novo designed", + "claudin", "solubilized" ], "keywords":[ - "accuracy", - "stability", - "biophysical", - "thermal", - "enabling", - "demonstrate", - "expansion", - "designs", - "proteome", - "functional", - "membrane", - "proteins", - "analyses", + "designed", + "complex", + "design", + "space", + "learning", + "structural", "receptors", - "unique", - "use", - "remarkable", - "substantial", + "show", + "rates", + "soluble", "de", - "novo", - "success", - "challenge", - "topologies", "experimental", - "drug", + "structures", + "functional", + "integral", + "approaches", + "enabling", "recapitulated", - "fold", - "means", - "1", - "discovery", - "designed", - "facto", "remains", - "functionalized", - "approaches", - "functions", - "robust", - "found", - "potentially", - "folds", - "leading", - "features", - "show", - "design", "enriched", "concept", - "structures", + "facto", + "bringing", + "fold", + "new", + "pipeline", + "functions", + "thermal", + "means", "protein", - "soluble", - "using", - "2", - "complex", - "space", - "analogues", + "solely", + "topologies", + "biophysical", + "stability", + "membrane", + "proteome", + "drug", + "proteins", + "remarkable", "solution", + "leading", + "analogues", + "accuracy", + "use", + "2", + "functionalities", + "novo", "high", - "bringing", + "demonstrate", "native", - "motifs", - "computational", - "solely", + "success", "proof", - "functionalities", - "deep", + "found", + "motifs", + "potentially", + "discovery", + "functionalized", "summary", - "learning", - "rates", - "structural", - "pipeline", - "integral", - "new" + "unique", + "features", + "analyses", + "challenge", + "designs", + "expansion", + "computational", + "substantial", + "using", + "folds", + "1", + "robust", + "deep" ], "release_date":"2023-10-18", "publication":"\"Computational design of soluble and functional membrane protein analogues\", Nature, 631, 449-458", @@ -757208,82 +760271,82 @@ "subtitle":"De novo designed rhomboid protease-like fold rpf_9", "tags":[ "de novo protein", - "de novo designed", "rhomboid protease", + "de novo designed", "solubilized" ], "keywords":[ - "accuracy", - "stability", - "biophysical", - "thermal", - "enabling", - "demonstrate", - "expansion", - "designs", - "proteome", - "functional", - "membrane", - "proteins", - "analyses", + "designed", + "complex", + "design", + "space", + "learning", + "structural", "receptors", - "unique", - "use", - "remarkable", - "substantial", + "show", + "rates", + "soluble", "de", - "novo", - "success", - "challenge", - "topologies", "experimental", - "drug", + "structures", + "functional", + "integral", + "approaches", + "enabling", "recapitulated", - "fold", - "means", - "1", - "discovery", - "designed", - "facto", "remains", - "functionalized", - "approaches", - "functions", - "robust", - "found", - "potentially", - "folds", - "leading", - "features", - "show", - "design", "enriched", "concept", - "structures", + "facto", + "bringing", + "fold", + "new", + "pipeline", + "functions", + "thermal", + "means", "protein", - "soluble", - "using", - "2", - "complex", - "space", - "analogues", + "solely", + "topologies", + "biophysical", + "stability", + "membrane", + "proteome", + "drug", + "proteins", + "remarkable", "solution", + "leading", + "analogues", + "accuracy", + "use", + "2", + "functionalities", + "novo", "high", - "bringing", + "demonstrate", "native", - "motifs", - "computational", - "solely", + "success", "proof", - "functionalities", - "deep", + "found", + "motifs", + "potentially", + "discovery", + "functionalized", "summary", - "learning", - "rates", - "structural", - "pipeline", - "integral", - "new" + "unique", + "features", + "analyses", + "challenge", + "designs", + "expansion", + "computational", + "substantial", + "using", + "folds", + "1", + "robust", + "deep" ], "release_date":"2023-10-18", "publication":"\"Computational design of soluble and functional membrane protein analogues\", Nature, 631, 449-458", @@ -757434,82 +760497,82 @@ "subtitle":"De novo designed soluble gpcr-like fold glf_18", "tags":[ "de novo protein", - "gpcr", "de novo designed", + "gpcr", "solubilized" ], "keywords":[ - "accuracy", - "stability", - "biophysical", - "thermal", - "enabling", - "demonstrate", - "expansion", - "designs", - "proteome", - "functional", - "membrane", - "proteins", - "analyses", + "designed", + "complex", + "design", + "space", + "learning", + "structural", "receptors", - "unique", - "use", - "remarkable", - "substantial", + "show", + "rates", + "soluble", "de", - "novo", - "success", - "challenge", - "topologies", "experimental", - "drug", + "structures", + "functional", + "integral", + "approaches", + "enabling", "recapitulated", - "fold", - "means", - "1", - "discovery", - "designed", - "facto", "remains", - "functionalized", - "approaches", - "functions", - "robust", - "found", - "potentially", - "folds", - "leading", - "features", - "show", - "design", "enriched", "concept", - "structures", + "facto", + "bringing", + "fold", + "new", + "pipeline", + "functions", + "thermal", + "means", "protein", - "soluble", - "using", - "2", - "complex", - "space", - "analogues", + "solely", + "topologies", + "biophysical", + "stability", + "membrane", + "proteome", + "drug", + "proteins", + "remarkable", "solution", + "leading", + "analogues", + "accuracy", + "use", + "2", + "functionalities", + "novo", "high", - "bringing", + "demonstrate", "native", - "motifs", - "computational", - "solely", + "success", "proof", - "functionalities", - "deep", + "found", + "motifs", + "potentially", + "discovery", + "functionalized", "summary", - "learning", - "rates", - "structural", - "pipeline", - "integral", - "new" + "unique", + "features", + "analyses", + "challenge", + "designs", + "expansion", + "computational", + "substantial", + "using", + "folds", + "1", + "robust", + "deep" ], "release_date":"2023-10-18", "publication":"\"Computational design of soluble and functional membrane protein analogues\", Nature, 631, 449-458", @@ -757663,82 +760726,82 @@ "subtitle":"De novo designed soluble gpcr-like fold glf_32", "tags":[ "de novo protein", - "gpcr", "de novo designed", + "gpcr", "solubilized" ], "keywords":[ - "accuracy", - "stability", - "biophysical", - "thermal", - "enabling", - "demonstrate", - "expansion", - "designs", - "proteome", - "functional", - "membrane", - "proteins", - "analyses", + "designed", + "complex", + "design", + "space", + "learning", + "structural", "receptors", - "unique", - "use", - "remarkable", - "substantial", + "show", + "rates", + "soluble", "de", - "novo", - "success", - "challenge", - "topologies", "experimental", - "drug", + "structures", + "functional", + "integral", + "approaches", + "enabling", "recapitulated", - "fold", - "means", - "1", - "discovery", - "designed", - "facto", "remains", - "functionalized", - "approaches", - "functions", - "robust", - "found", - "potentially", - "folds", - "leading", - "features", - "show", - "design", "enriched", "concept", - "structures", + "facto", + "bringing", + "fold", + "new", + "pipeline", + "functions", + "thermal", + "means", "protein", - "soluble", - "using", - "2", - "complex", - "space", - "analogues", + "solely", + "topologies", + "biophysical", + "stability", + "membrane", + "proteome", + "drug", + "proteins", + "remarkable", "solution", + "leading", + "analogues", + "accuracy", + "use", + "2", + "functionalities", + "novo", "high", - "bringing", + "demonstrate", "native", - "motifs", - "computational", - "solely", + "success", "proof", - "functionalities", - "deep", + "found", + "motifs", + "potentially", + "discovery", + "functionalized", "summary", - "learning", - "rates", - "structural", - "pipeline", - "integral", - "new" + "unique", + "features", + "analyses", + "challenge", + "designs", + "expansion", + "computational", + "substantial", + "using", + "folds", + "1", + "robust", + "deep" ], "release_date":"2023-10-18", "publication":"\"Computational design of soluble and functional membrane protein analogues\", Nature, 631, 449-458", @@ -757838,101 +760901,101 @@ ], "subtitle":"Coiled-coil protein origami triangle", "tags":[ - "protein origami", + "designed protein", "de novo protein", "coiled-coil", - "designed protein" + "protein origami" ], "keywords":[ - "providing", - "available", - "cyclization", - "strategy", - "densely", - "triangle", - "knot", - "lattice", - "uses", - "parallel", - "crystal", - "interactions", - "packed", - "designing", - "structure", - "predict", - "building", - "principles", - "p3", - "novel", - "contacts", - "nanobodies", - "chain", - "validates", - "topology", - "proteins", + "dimers", + "interestingly", + "molecular", + "structural", "number", - "short", "cavity", - "structures", - "ultimately", - "edges", - "p2", - "natural", - "gcn", - "neither", - "origami", - "crystallization", - "polyhedral", - "molecular", - "alphafold2", - "additionally", - "connected", - "orthogonal", - "large", - "linkers", - "report", - "globular", - "triangles", - "topologies", - "shape", + "p3", + "neighboring", "information", - "vertex", - "successful", - "blocks", - "design", - "interestingly", + "densely", + "topological", "polypeptide", + "short", + "new", + "strategy", + "insight", + "protein", + "topologies", + "globular", "facilitated", - "p4", + "stabilization", "ccpo", - "segments", - "stabilized", + "crystal", + "correct", + "formed", + "opportunities", + "enabled", + "neither", + "p4", + "connected", "fails", - "underlying", - "structural", - "stabilization", - "diverse", - "fold", - "insight", + "contacts", + "orthogonal", + "blocks", + "proteins", + "large", + "nanobodies", + "2", "modular", - "proven", - "neighboring", - "topological", + "available", + "homodimer", + "predict", + "p1", + "triangle", + "designing", + "design", + "topology", + "packed", + "principles", + "diverse", + "chain", + "natural", "inclusion", - "folds", - "dimers", - "correct", + "fold", "addition", + "successful", + "segments", + "underlying", + "parallel", + "building", + "uses", + "triangles", + "folds", + "p2", "central", - "protein", - "2", - "homodimer", + "alphafold2", + "gcn", + "providing", + "structures", + "knot", + "polyhedral", + "vertex", + "crystallization", + "structure", + "report", + "shape", + "additionally", + "validates", + "cyclization", + "interactions", + "linkers", + "lattice", + "origami", + "proven", "distinct", - "enabled", - "p1", - "opportunities", - "formed", - "new" + "ultimately", + "edges", + "stabilized", + "novel" ], "release_date":"2023-08-02", "publication":"\"Crystal Structure of de Novo Designed Coiled-Coil Protein Origami Triangle\", J.Am.Chem.Soc., 145, 16995-17000", @@ -758060,11 +761123,11 @@ }, { "sim":57.0, - "partner":"6mi4" + "partner":"6mi3" }, { "sim":57.0, - "partner":"6mi3" + "partner":"6mi4" }, { "sim":57.0, @@ -758106,10 +761169,6 @@ "sim":55.0, "partner":"7fgf" }, - { - "sim":55.0, - "partner":"6hn4" - }, { "sim":55.0, "partner":"6hn5" @@ -758120,11 +761179,7 @@ }, { "sim":55.0, - "partner":"6vwg" - }, - { - "sim":55.0, - "partner":"6vwh" + "partner":"6hn4" }, { "sim":55.0, @@ -758146,6 +761201,14 @@ "sim":55.0, "partner":"7s8v" }, + { + "sim":55.0, + "partner":"6vwg" + }, + { + "sim":55.0, + "partner":"6vwh" + }, { "sim":54.0, "partner":"1gk6" @@ -758188,15 +761251,15 @@ }, { "sim":53.0, - "partner":"4dme" + "partner":"1zta" }, { "sim":53.0, - "partner":"4nj0" + "partner":"4dme" }, { "sim":53.0, - "partner":"1zta" + "partner":"4nj0" }, { "sim":53.0, @@ -758292,11 +761355,11 @@ }, { "sim":51.0, - "partner":"4niz" + "partner":"4tl1" }, { "sim":51.0, - "partner":"4tl1" + "partner":"4niz" }, { "sim":51.0, @@ -758338,10 +761401,6 @@ "sim":50.0, "partner":"1rb4" }, - { - "sim":50.0, - "partner":"1rb5" - }, { "sim":50.0, "partner":"1rb6" @@ -758358,6 +761417,10 @@ "sim":50.0, "partner":"1zij" }, + { + "sim":50.0, + "partner":"1rb5" + }, { "sim":50.0, "partner":"2o7h" @@ -758444,12 +761507,12 @@ ], "subtitle":"Crystal structure of the sake2be protein", "tags":[ - "propeller", - "scaffold", - "computational", "design", + "unknown function", + "propeller", "kelch", - "unknown function" + "computational", + "scaffold" ], "keywords":[ "description", @@ -758494,11 +761557,11 @@ }, { "sim":199.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":199.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":199.0, @@ -758638,25 +761701,17 @@ "sim":130.0, "partner":"6zez" }, - { - "sim":130.0, - "partner":"5fnq" - }, { "sim":130.0, "partner":"6zf0" }, - { - "sim":130.0, - "partner":"5fnr" - }, { "sim":130.0, "partner":"6zf1" }, { "sim":130.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":130.0, @@ -758664,7 +761719,7 @@ }, { "sim":130.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":130.0, @@ -758672,19 +761727,23 @@ }, { "sim":130.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":130.0, "partner":"6zf4" }, + { + "sim":130.0, + "partner":"5fnt" + }, { "sim":130.0, "partner":"6zf5" }, { "sim":130.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":130.0, @@ -758694,6 +761753,10 @@ "sim":130.0, "partner":"6zf7" }, + { + "sim":130.0, + "partner":"5fzj" + }, { "sim":130.0, "partner":"6zf8" @@ -758712,15 +761775,15 @@ }, { "sim":130.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":130.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":130.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":130.0, @@ -758732,11 +761795,11 @@ }, { "sim":130.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":130.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":130.0, @@ -758826,17 +761889,13 @@ "sim":128.0, "partner":"4xmb" }, - { - "sim":128.0, - "partner":"7k2m" - }, { "sim":128.0, "partner":"6hws" }, { "sim":128.0, - "partner":"7k2r" + "partner":"7k2m" }, { "sim":128.0, @@ -758864,11 +761923,7 @@ }, { "sim":128.0, - "partner":"5x54" - }, - { - "sim":128.0, - "partner":"6rog" + "partner":"7k2r" }, { "sim":128.0, @@ -758884,23 +761939,31 @@ }, { "sim":128.0, - "partner":"7xm3" + "partner":"5x54" }, { "sim":128.0, - "partner":"7xm4" + "partner":"6rog" }, { "sim":128.0, - "partner":"7xm5" + "partner":"7xot" }, { "sim":128.0, - "partner":"7xot" + "partner":"7xm2" }, { "sim":128.0, - "partner":"7xm2" + "partner":"7xm3" + }, + { + "sim":128.0, + "partner":"7xm4" + }, + { + "sim":128.0, + "partner":"7xm5" }, { "sim":128.0, @@ -758926,10 +761989,6 @@ "sim":128.0, "partner":"6tym" }, - { - "sim":128.0, - "partner":"7q5h" - }, { "sim":128.0, "partner":"6z6a" @@ -758952,19 +762011,19 @@ }, { "sim":128.0, - "partner":"5f72" + "partner":"7q5h" }, { "sim":128.0, - "partner":"4iqk" + "partner":"5f72" }, { "sim":128.0, - "partner":"4in4" + "partner":"4iqk" }, { "sim":128.0, - "partner":"4l7d" + "partner":"4in4" }, { "sim":128.0, @@ -758980,7 +762039,7 @@ }, { "sim":128.0, - "partner":"7k2g" + "partner":"4l7d" }, { "sim":128.0, @@ -759030,6 +762089,10 @@ "sim":128.0, "partner":"7k2p" }, + { + "sim":128.0, + "partner":"7k2g" + }, { "sim":128.0, "partner":"1zgk" @@ -759060,23 +762123,23 @@ }, { "sim":128.0, - "partner":"8ivr" + "partner":"8ivg" }, { "sim":128.0, - "partner":"8xgv" + "partner":"8ixs" }, { "sim":128.0, - "partner":"8ivg" + "partner":"8xgk" }, { "sim":128.0, - "partner":"8ixs" + "partner":"8ivr" }, { "sim":128.0, - "partner":"8xgk" + "partner":"8xgv" }, { "sim":128.0, @@ -759108,23 +762171,23 @@ }, { "sim":128.0, - "partner":"5wg1" + "partner":"8ehv" }, { "sim":128.0, - "partner":"8ehv" + "partner":"5wg1" }, { "sim":128.0, - "partner":"5who" + "partner":"8ejr" }, { "sim":128.0, - "partner":"5wfl" + "partner":"5who" }, { "sim":128.0, - "partner":"8ejr" + "partner":"5wfl" }, { "sim":128.0, @@ -759172,11 +762235,11 @@ }, { "sim":117.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":117.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":110.0, @@ -759184,7 +762247,7 @@ }, { "sim":103.0, - "partner":"8rbh" + "partner":"8oio" }, { "sim":103.0, @@ -759196,11 +762259,11 @@ }, { "sim":103.0, - "partner":"8oio" + "partner":"6ttk" }, { "sim":103.0, - "partner":"6ttk" + "partner":"8rbh" }, { "sim":102.0, @@ -759212,19 +762275,19 @@ }, { "sim":76.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":76.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":72.0, - "partner":"8khp" + "partner":"8w4j" }, { "sim":72.0, - "partner":"8w4j" + "partner":"8khp" }, { "sim":72.0, @@ -759471,12 +762534,12 @@ ], "subtitle":"Crystal structure of the sake6ac-lb protein", "tags":[ - "propeller", - "scaffold", - "computational", "design", + "unknown function", + "propeller", "kelch", - "unknown function" + "computational", + "scaffold" ], "keywords":[ "description", @@ -759529,11 +762592,11 @@ }, { "sim":498.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":498.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":498.0, @@ -759653,10 +762716,6 @@ "sim":316.0, "partner":"6hws" }, - { - "sim":316.0, - "partner":"6rog" - }, { "sim":316.0, "partner":"4ifj" @@ -759671,27 +762730,27 @@ }, { "sim":316.0, - "partner":"7xm3" + "partner":"6rog" }, { "sim":316.0, - "partner":"7xm4" + "partner":"7xot" }, { "sim":316.0, - "partner":"7xm5" + "partner":"7xm2" }, { "sim":316.0, - "partner":"7xot" + "partner":"7xm3" }, { "sim":316.0, - "partner":"7xm2" + "partner":"7xm4" }, { "sim":316.0, - "partner":"4l7d" + "partner":"7xm5" }, { "sim":316.0, @@ -759705,6 +762764,10 @@ "sim":316.0, "partner":"4n1b" }, + { + "sim":316.0, + "partner":"4l7d" + }, { "sim":316.0, "partner":"7k2h" @@ -759739,23 +762802,23 @@ }, { "sim":316.0, - "partner":"8ivr" + "partner":"8ivg" }, { "sim":316.0, - "partner":"8xgv" + "partner":"8ixs" }, { "sim":316.0, - "partner":"8ivg" + "partner":"8xgk" }, { "sim":316.0, - "partner":"8ixs" + "partner":"8ivr" }, { "sim":316.0, - "partner":"8xgk" + "partner":"8xgv" }, { "sim":316.0, @@ -759869,25 +762932,17 @@ "sim":312.0, "partner":"6zez" }, - { - "sim":312.0, - "partner":"5fnq" - }, { "sim":312.0, "partner":"6zf0" }, - { - "sim":312.0, - "partner":"5fnr" - }, { "sim":312.0, "partner":"6zf1" }, { "sim":312.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":312.0, @@ -759895,7 +762950,7 @@ }, { "sim":312.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":312.0, @@ -759903,19 +762958,23 @@ }, { "sim":312.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":312.0, "partner":"6zf4" }, + { + "sim":312.0, + "partner":"5fnt" + }, { "sim":312.0, "partner":"6zf5" }, { "sim":312.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":312.0, @@ -759925,6 +762984,10 @@ "sim":312.0, "partner":"6zf7" }, + { + "sim":312.0, + "partner":"5fzj" + }, { "sim":312.0, "partner":"6zf8" @@ -759941,10 +763004,6 @@ "sim":312.0, "partner":"3zgd" }, - { - "sim":312.0, - "partner":"4zy3" - }, { "sim":312.0, "partner":"3wdz" @@ -759955,12 +763014,16 @@ }, { "sim":312.0, - "partner":"1x2j" + "partner":"4zy3" }, { "sim":312.0, "partner":"1x2r" }, + { + "sim":312.0, + "partner":"1x2j" + }, { "sim":312.0, "partner":"2z32" @@ -760063,32 +763126,28 @@ }, { "sim":311.0, - "partner":"5wg1" + "partner":"8ehv" }, { "sim":311.0, - "partner":"8ehv" + "partner":"5wg1" }, { "sim":311.0, - "partner":"5who" + "partner":"8ejr" }, { "sim":311.0, - "partner":"5wfl" + "partner":"5who" }, { "sim":311.0, - "partner":"8ejr" + "partner":"5wfl" }, { "sim":311.0, "partner":"8ejs" }, - { - "sim":310.0, - "partner":"7k2r" - }, { "sim":310.0, "partner":"7k28" @@ -760115,7 +763174,7 @@ }, { "sim":310.0, - "partner":"7q5h" + "partner":"7k2r" }, { "sim":310.0, @@ -760139,7 +763198,7 @@ }, { "sim":310.0, - "partner":"7k2g" + "partner":"7q5h" }, { "sim":310.0, @@ -760165,6 +763224,10 @@ "sim":310.0, "partner":"7k2e" }, + { + "sim":310.0, + "partner":"7k2g" + }, { "sim":309.0, "partner":"7k2l" @@ -760187,7 +763250,7 @@ }, { "sim":284.0, - "partner":"8rbh" + "partner":"8oio" }, { "sim":284.0, @@ -760199,11 +763262,11 @@ }, { "sim":284.0, - "partner":"8oio" + "partner":"6ttk" }, { "sim":284.0, - "partner":"6ttk" + "partner":"8rbh" }, { "sim":275.0, @@ -760219,11 +763282,11 @@ }, { "sim":260.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":260.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":258.0, @@ -760239,19 +763302,19 @@ }, { "sim":176.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":176.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":149.0, - "partner":"8khp" + "partner":"8w4j" }, { "sim":149.0, - "partner":"8w4j" + "partner":"8khp" }, { "sim":149.0, @@ -760345,10 +763408,6 @@ "sim":51.0, "partner":"7k5b" }, - { - "sim":51.0, - "partner":"6zyw" - }, { "sim":51.0, "partner":"8bx8" @@ -760364,6 +763423,10 @@ { "sim":51.0, "partner":"7moq" + }, + { + "sim":51.0, + "partner":"6zyw" } ], "struct_thr_sim_designed":[ @@ -760502,12 +763565,12 @@ ], "subtitle":"Crystal structure of the computationally designed sake6ceref protein", "tags":[ - "propeller", - "scaffold", - "computational", "design", + "unknown function", + "propeller", "kelch", - "unknown function" + "computational", + "scaffold" ], "keywords":[ "description", @@ -760560,15 +763623,15 @@ }, { "sim":422.0, - "partner":"7onc" + "partner":"7pvp" }, { "sim":422.0, - "partner":"7one" + "partner":"7onc" }, { "sim":422.0, - "partner":"7pvp" + "partner":"7one" }, { "sim":421.0, @@ -760576,11 +763639,11 @@ }, { "sim":415.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":415.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":415.0, @@ -760678,27 +763741,23 @@ }, { "sim":290.0, - "partner":"7xm3" - }, - { - "sim":290.0, - "partner":"7xm4" + "partner":"7xot" }, { "sim":290.0, - "partner":"7xm5" + "partner":"7xm2" }, { "sim":290.0, - "partner":"7xot" + "partner":"7xm3" }, { "sim":290.0, - "partner":"7xm2" + "partner":"7xm4" }, { "sim":290.0, - "partner":"4l7d" + "partner":"7xm5" }, { "sim":290.0, @@ -760712,6 +763771,10 @@ "sim":290.0, "partner":"4n1b" }, + { + "sim":290.0, + "partner":"4l7d" + }, { "sim":290.0, "partner":"7of8" @@ -760756,25 +763819,17 @@ "sim":290.0, "partner":"6zez" }, - { - "sim":290.0, - "partner":"5fnq" - }, { "sim":290.0, "partner":"6zf0" }, - { - "sim":290.0, - "partner":"5fnr" - }, { "sim":290.0, "partner":"6zf1" }, { "sim":290.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":290.0, @@ -760782,7 +763837,7 @@ }, { "sim":290.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":290.0, @@ -760790,19 +763845,23 @@ }, { "sim":290.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":290.0, "partner":"6zf4" }, + { + "sim":290.0, + "partner":"5fnt" + }, { "sim":290.0, "partner":"6zf5" }, { "sim":290.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":290.0, @@ -760812,6 +763871,10 @@ "sim":290.0, "partner":"6zf7" }, + { + "sim":290.0, + "partner":"5fzj" + }, { "sim":290.0, "partner":"6zf8" @@ -760888,10 +763951,6 @@ "sim":289.0, "partner":"6hws" }, - { - "sim":289.0, - "partner":"6rog" - }, { "sim":289.0, "partner":"4ifj" @@ -760908,6 +763967,10 @@ "sim":289.0, "partner":"7ofe" }, + { + "sim":289.0, + "partner":"6rog" + }, { "sim":289.0, "partner":"7yen" @@ -760946,31 +764009,31 @@ }, { "sim":289.0, - "partner":"8ivr" + "partner":"8ivg" }, { "sim":289.0, - "partner":"8xgv" + "partner":"8ixs" }, { "sim":289.0, - "partner":"8ivg" + "partner":"8xgk" }, { "sim":289.0, - "partner":"8ixs" + "partner":"8ivr" }, { "sim":289.0, - "partner":"8xgk" + "partner":"8xgv" }, { "sim":289.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":289.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":289.0, @@ -761018,15 +764081,15 @@ }, { "sim":288.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":288.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":288.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":288.0, @@ -761098,32 +764161,28 @@ }, { "sim":285.0, - "partner":"5wg1" + "partner":"8ehv" }, { "sim":285.0, - "partner":"8ehv" + "partner":"5wg1" }, { "sim":285.0, - "partner":"5who" + "partner":"8ejr" }, { "sim":285.0, - "partner":"5wfl" + "partner":"5who" }, { "sim":285.0, - "partner":"8ejr" + "partner":"5wfl" }, { "sim":285.0, "partner":"8ejs" }, - { - "sim":284.0, - "partner":"7k2r" - }, { "sim":284.0, "partner":"7k28" @@ -761150,7 +764209,7 @@ }, { "sim":284.0, - "partner":"7q5h" + "partner":"7k2r" }, { "sim":284.0, @@ -761174,11 +764233,11 @@ }, { "sim":284.0, - "partner":"5yq4" + "partner":"7q5h" }, { "sim":284.0, - "partner":"7k2g" + "partner":"5yq4" }, { "sim":284.0, @@ -761204,6 +764263,10 @@ "sim":284.0, "partner":"7k2e" }, + { + "sim":284.0, + "partner":"7k2g" + }, { "sim":284.0, "partner":"6gy5" @@ -761218,11 +764281,11 @@ }, { "sim":244.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":244.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":243.0, @@ -761246,7 +764309,7 @@ }, { "sim":211.0, - "partner":"8rbh" + "partner":"8oio" }, { "sim":211.0, @@ -761258,11 +764321,11 @@ }, { "sim":211.0, - "partner":"8oio" + "partner":"6ttk" }, { "sim":211.0, - "partner":"6ttk" + "partner":"8rbh" }, { "sim":147.0, @@ -761270,19 +764333,19 @@ }, { "sim":141.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":141.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":136.0, - "partner":"8khp" + "partner":"8w4j" }, { "sim":136.0, - "partner":"8w4j" + "partner":"8khp" }, { "sim":136.0, @@ -761442,12 +764505,12 @@ ], "subtitle":"Crystal structure of the computationally designed sake6deref protein", "tags":[ - "propeller", - "scaffold", - "computational", "design", + "unknown function", + "propeller", "kelch", - "unknown function" + "computational", + "scaffold" ], "keywords":[ "description", @@ -761536,11 +764599,11 @@ }, { "sim":456.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":456.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":456.0, @@ -761644,10 +764707,6 @@ "sim":290.0, "partner":"6hws" }, - { - "sim":290.0, - "partner":"6rog" - }, { "sim":290.0, "partner":"4ifj" @@ -761662,27 +764721,27 @@ }, { "sim":290.0, - "partner":"7xm3" + "partner":"6rog" }, { "sim":290.0, - "partner":"7xm4" + "partner":"7xot" }, { "sim":290.0, - "partner":"7xm5" + "partner":"7xm2" }, { "sim":290.0, - "partner":"7xot" + "partner":"7xm3" }, { "sim":290.0, - "partner":"7xm2" + "partner":"7xm4" }, { "sim":290.0, - "partner":"4l7d" + "partner":"7xm5" }, { "sim":290.0, @@ -761696,6 +764755,10 @@ "sim":290.0, "partner":"4n1b" }, + { + "sim":290.0, + "partner":"4l7d" + }, { "sim":290.0, "partner":"7k2h" @@ -761734,23 +764797,23 @@ }, { "sim":290.0, - "partner":"8ivr" + "partner":"8ivg" }, { "sim":290.0, - "partner":"8xgv" + "partner":"8ixs" }, { "sim":290.0, - "partner":"8ivg" + "partner":"8xgk" }, { "sim":290.0, - "partner":"8ixs" + "partner":"8ivr" }, { "sim":290.0, - "partner":"8xgk" + "partner":"8xgv" }, { "sim":290.0, @@ -761848,25 +764911,17 @@ "sim":287.0, "partner":"6zez" }, - { - "sim":287.0, - "partner":"5fnq" - }, { "sim":287.0, "partner":"6zf0" }, - { - "sim":287.0, - "partner":"5fnr" - }, { "sim":287.0, "partner":"6zf1" }, { "sim":287.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":287.0, @@ -761874,7 +764929,7 @@ }, { "sim":287.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":287.0, @@ -761882,19 +764937,23 @@ }, { "sim":287.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":287.0, "partner":"6zf4" }, + { + "sim":287.0, + "partner":"5fnt" + }, { "sim":287.0, "partner":"6zf5" }, { "sim":287.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":287.0, @@ -761904,6 +764963,10 @@ "sim":287.0, "partner":"6zf7" }, + { + "sim":287.0, + "partner":"5fzj" + }, { "sim":287.0, "partner":"6zf8" @@ -761914,11 +764977,11 @@ }, { "sim":287.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":287.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":287.0, @@ -761998,15 +765061,15 @@ }, { "sim":286.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":286.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":286.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":285.0, @@ -762062,23 +765125,23 @@ }, { "sim":285.0, - "partner":"5wg1" + "partner":"8ehv" }, { "sim":285.0, - "partner":"8ehv" + "partner":"5wg1" }, { "sim":285.0, - "partner":"5who" + "partner":"8ejr" }, { "sim":285.0, - "partner":"5wfl" + "partner":"5who" }, { "sim":285.0, - "partner":"8ejr" + "partner":"5wfl" }, { "sim":285.0, @@ -762092,10 +765155,6 @@ "sim":284.0, "partner":"7k2m" }, - { - "sim":284.0, - "partner":"7k2r" - }, { "sim":284.0, "partner":"7k28" @@ -762122,7 +765181,7 @@ }, { "sim":284.0, - "partner":"7q5h" + "partner":"7k2r" }, { "sim":284.0, @@ -762146,7 +765205,7 @@ }, { "sim":284.0, - "partner":"7k2g" + "partner":"7q5h" }, { "sim":284.0, @@ -762172,6 +765231,10 @@ "sim":284.0, "partner":"7k2e" }, + { + "sim":284.0, + "partner":"7k2g" + }, { "sim":257.0, "partner":"6hrl" @@ -762186,15 +765249,15 @@ }, { "sim":245.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":245.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":235.0, - "partner":"8rbh" + "partner":"8oio" }, { "sim":235.0, @@ -762206,11 +765269,11 @@ }, { "sim":235.0, - "partner":"8oio" + "partner":"6ttk" }, { "sim":235.0, - "partner":"6ttk" + "partner":"8rbh" }, { "sim":231.0, @@ -762226,19 +765289,19 @@ }, { "sim":158.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":158.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":147.0, - "partner":"8khp" + "partner":"8w4j" }, { "sim":147.0, - "partner":"8w4j" + "partner":"8khp" }, { "sim":147.0, @@ -762410,12 +765473,12 @@ ], "subtitle":"Crystal structure of the computationally designed sake6detal protein", "tags":[ - "propeller", - "scaffold", - "computational", "design", + "unknown function", + "propeller", "kelch", - "unknown function" + "computational", + "scaffold" ], "keywords":[ "description", @@ -762504,11 +765567,11 @@ }, { "sim":406.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":406.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":406.0, @@ -762544,15 +765607,15 @@ }, { "sim":60.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":60.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":60.0, - "partner":"7ax2" + "partner":"7ax0" } ], "seq_thr_sim_natural":[ @@ -762560,10 +765623,6 @@ "sim":417.0, "partner":"8p2u" }, - { - "sim":301.0, - "partner":"4l7d" - }, { "sim":301.0, "partner":"4l7b" @@ -762576,6 +765635,10 @@ "sim":301.0, "partner":"4n1b" }, + { + "sim":301.0, + "partner":"4l7d" + }, { "sim":300.0, "partner":"7k2h" @@ -762602,23 +765665,23 @@ }, { "sim":300.0, - "partner":"8ivr" + "partner":"8ivg" }, { "sim":300.0, - "partner":"8xgv" + "partner":"8ixs" }, { "sim":300.0, - "partner":"8ivg" + "partner":"8xgk" }, { "sim":300.0, - "partner":"8ixs" + "partner":"8ivr" }, { "sim":300.0, - "partner":"8xgk" + "partner":"8xgv" }, { "sim":300.0, @@ -762646,43 +765709,43 @@ }, { "sim":299.0, - "partner":"5x54" + "partner":"4ifj" }, { "sim":299.0, - "partner":"6rog" + "partner":"4ifl" }, { "sim":299.0, - "partner":"4ifj" + "partner":"4ifn" }, { "sim":299.0, - "partner":"4ifl" + "partner":"5x54" }, { "sim":299.0, - "partner":"4ifn" + "partner":"6rog" }, { "sim":299.0, - "partner":"7xm3" + "partner":"7xot" }, { "sim":299.0, - "partner":"7xm4" + "partner":"7xm2" }, { "sim":299.0, - "partner":"7xm5" + "partner":"7xm3" }, { "sim":299.0, - "partner":"7xot" + "partner":"7xm4" }, { "sim":299.0, - "partner":"7xm2" + "partner":"7xm5" }, { "sim":299.0, @@ -762736,10 +765799,6 @@ "sim":294.0, "partner":"7k2m" }, - { - "sim":294.0, - "partner":"7k2r" - }, { "sim":294.0, "partner":"7k28" @@ -762764,6 +765823,10 @@ "sim":294.0, "partner":"7k2q" }, + { + "sim":294.0, + "partner":"7k2r" + }, { "sim":294.0, "partner":"6sp1" @@ -762780,10 +765843,6 @@ "sim":294.0, "partner":"6sp4" }, - { - "sim":294.0, - "partner":"7q5h" - }, { "sim":294.0, "partner":"6z6a" @@ -762806,11 +765865,11 @@ }, { "sim":294.0, - "partner":"4iqk" + "partner":"7q5h" }, { "sim":294.0, - "partner":"7k2g" + "partner":"4iqk" }, { "sim":294.0, @@ -762836,6 +765895,10 @@ "sim":294.0, "partner":"7k2e" }, + { + "sim":294.0, + "partner":"7k2g" + }, { "sim":294.0, "partner":"3zgc" @@ -762874,23 +765937,23 @@ }, { "sim":294.0, - "partner":"5wg1" + "partner":"8ehv" }, { "sim":294.0, - "partner":"8ehv" + "partner":"5wg1" }, { "sim":294.0, - "partner":"5who" + "partner":"8ejr" }, { "sim":294.0, - "partner":"5wfl" + "partner":"5who" }, { "sim":294.0, - "partner":"8ejr" + "partner":"5wfl" }, { "sim":294.0, @@ -762956,25 +766019,17 @@ "sim":293.0, "partner":"6zez" }, - { - "sim":293.0, - "partner":"5fnq" - }, { "sim":293.0, "partner":"6zf0" }, - { - "sim":293.0, - "partner":"5fnr" - }, { "sim":293.0, "partner":"6zf1" }, { "sim":293.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":293.0, @@ -762982,7 +766037,7 @@ }, { "sim":293.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":293.0, @@ -762990,19 +766045,23 @@ }, { "sim":293.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":293.0, "partner":"6zf4" }, + { + "sim":293.0, + "partner":"5fnt" + }, { "sim":293.0, "partner":"6zf5" }, { "sim":293.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":293.0, @@ -763012,6 +766071,10 @@ "sim":293.0, "partner":"6zf7" }, + { + "sim":293.0, + "partner":"5fzj" + }, { "sim":293.0, "partner":"6zf8" @@ -763038,11 +766101,11 @@ }, { "sim":293.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":293.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":293.0, @@ -763118,15 +766181,15 @@ }, { "sim":292.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":292.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":292.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":271.0, @@ -763154,15 +766217,15 @@ }, { "sim":217.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":217.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":214.0, - "partner":"8rbh" + "partner":"8oio" }, { "sim":214.0, @@ -763174,11 +766237,11 @@ }, { "sim":214.0, - "partner":"8oio" + "partner":"6ttk" }, { "sim":214.0, - "partner":"6ttk" + "partner":"8rbh" }, { "sim":214.0, @@ -763194,19 +766257,19 @@ }, { "sim":153.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":153.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":138.0, - "partner":"8khp" + "partner":"8w4j" }, { "sim":138.0, - "partner":"8w4j" + "partner":"8khp" }, { "sim":138.0, @@ -763418,12 +766481,12 @@ ], "subtitle":"Crystal structure of the computationally designed sake6dr protein", "tags":[ - "propeller", - "scaffold", - "computational", "design", + "unknown function", + "propeller", "kelch", - "unknown function" + "computational", + "scaffold" ], "keywords":[ "description", @@ -763512,11 +766575,11 @@ }, { "sim":462.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":462.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":462.0, @@ -763606,23 +766669,23 @@ }, { "sim":294.0, - "partner":"8ivr" + "partner":"8ivg" }, { "sim":294.0, - "partner":"8xgv" + "partner":"8ixs" }, { "sim":294.0, - "partner":"8ivg" + "partner":"8xgk" }, { "sim":294.0, - "partner":"8ixs" + "partner":"8ivr" }, { "sim":294.0, - "partner":"8xgk" + "partner":"8xgv" }, { "sim":294.0, @@ -763648,14 +766711,6 @@ "sim":293.0, "partner":"6hws" }, - { - "sim":293.0, - "partner":"5x54" - }, - { - "sim":293.0, - "partner":"6rog" - }, { "sim":293.0, "partner":"4ifj" @@ -763670,27 +766725,31 @@ }, { "sim":293.0, - "partner":"7xm3" + "partner":"5x54" }, { "sim":293.0, - "partner":"7xm4" + "partner":"6rog" }, { "sim":293.0, - "partner":"7xm5" + "partner":"7xot" }, { "sim":293.0, - "partner":"7xot" + "partner":"7xm2" }, { "sim":293.0, - "partner":"7xm2" + "partner":"7xm3" }, { "sim":293.0, - "partner":"4l7d" + "partner":"7xm4" + }, + { + "sim":293.0, + "partner":"7xm5" }, { "sim":293.0, @@ -763704,6 +766763,10 @@ "sim":293.0, "partner":"4n1b" }, + { + "sim":293.0, + "partner":"4l7d" + }, { "sim":293.0, "partner":"7k2h" @@ -763808,25 +766871,17 @@ "sim":291.0, "partner":"6zez" }, - { - "sim":291.0, - "partner":"5fnq" - }, { "sim":291.0, "partner":"6zf0" }, - { - "sim":291.0, - "partner":"5fnr" - }, { "sim":291.0, "partner":"6zf1" }, { "sim":291.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":291.0, @@ -763834,7 +766889,7 @@ }, { "sim":291.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":291.0, @@ -763842,19 +766897,23 @@ }, { "sim":291.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":291.0, "partner":"6zf4" }, + { + "sim":291.0, + "partner":"5fnt" + }, { "sim":291.0, "partner":"6zf5" }, { "sim":291.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":291.0, @@ -763864,6 +766923,10 @@ "sim":291.0, "partner":"6zf7" }, + { + "sim":291.0, + "partner":"5fzj" + }, { "sim":291.0, "partner":"6zf8" @@ -763878,11 +766941,11 @@ }, { "sim":291.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":291.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":291.0, @@ -763998,15 +767061,15 @@ }, { "sim":289.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":289.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":289.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":289.0, @@ -764038,32 +767101,28 @@ }, { "sim":289.0, - "partner":"5wg1" + "partner":"8ehv" }, { "sim":289.0, - "partner":"8ehv" + "partner":"5wg1" }, { "sim":289.0, - "partner":"5who" + "partner":"8ejr" }, { "sim":289.0, - "partner":"5wfl" + "partner":"5who" }, { "sim":289.0, - "partner":"8ejr" + "partner":"5wfl" }, { "sim":289.0, "partner":"8ejs" }, - { - "sim":288.0, - "partner":"7k2r" - }, { "sim":288.0, "partner":"7k28" @@ -764090,7 +767149,7 @@ }, { "sim":288.0, - "partner":"7k2g" + "partner":"7k2r" }, { "sim":288.0, @@ -764117,16 +767176,16 @@ "partner":"7k2e" }, { - "sim":287.0, - "partner":"7k2l" + "sim":288.0, + "partner":"7k2g" }, { "sim":287.0, - "partner":"7k2m" + "partner":"7k2l" }, { "sim":287.0, - "partner":"7q5h" + "partner":"7k2m" }, { "sim":287.0, @@ -764148,6 +767207,10 @@ "sim":287.0, "partner":"7q6s" }, + { + "sim":287.0, + "partner":"7q5h" + }, { "sim":261.0, "partner":"6hrl" @@ -764162,15 +767225,15 @@ }, { "sim":245.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":245.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":241.0, - "partner":"8rbh" + "partner":"8oio" }, { "sim":241.0, @@ -764182,11 +767245,11 @@ }, { "sim":241.0, - "partner":"8oio" + "partner":"6ttk" }, { "sim":241.0, - "partner":"6ttk" + "partner":"8rbh" }, { "sim":229.0, @@ -764202,19 +767265,19 @@ }, { "sim":155.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":155.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":146.0, - "partner":"8khp" + "partner":"8w4j" }, { "sim":146.0, - "partner":"8w4j" + "partner":"8khp" }, { "sim":146.0, @@ -764386,12 +767449,12 @@ ], "subtitle":"Crystal structure of the computationally designed sake6fe protein", "tags":[ - "propeller", - "scaffold", - "computational", "design", + "unknown function", + "propeller", "kelch", - "unknown function" + "computational", + "scaffold" ], "keywords":[ "description", @@ -764456,11 +767519,11 @@ }, { "sim":419.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":419.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":419.0, @@ -764532,10 +767595,6 @@ "sim":317.0, "partner":"6hws" }, - { - "sim":317.0, - "partner":"6rog" - }, { "sim":317.0, "partner":"4ifj" @@ -764550,19 +767609,19 @@ }, { "sim":317.0, - "partner":"6typ" + "partner":"6rog" }, { "sim":317.0, - "partner":"6tym" + "partner":"6typ" }, { "sim":317.0, - "partner":"4in4" + "partner":"6tym" }, { "sim":317.0, - "partner":"4l7d" + "partner":"4in4" }, { "sim":317.0, @@ -764576,6 +767635,10 @@ "sim":317.0, "partner":"4n1b" }, + { + "sim":317.0, + "partner":"4l7d" + }, { "sim":317.0, "partner":"7k2h" @@ -764626,23 +767689,23 @@ }, { "sim":317.0, - "partner":"8ivr" + "partner":"8ivg" }, { "sim":317.0, - "partner":"8xgv" + "partner":"8ixs" }, { "sim":317.0, - "partner":"8ivg" + "partner":"8xgk" }, { "sim":317.0, - "partner":"8ixs" + "partner":"8ivr" }, { "sim":317.0, - "partner":"8xgk" + "partner":"8xgv" }, { "sim":317.0, @@ -764662,23 +767725,23 @@ }, { "sim":316.0, - "partner":"7xm3" + "partner":"7xot" }, { "sim":316.0, - "partner":"7xm4" + "partner":"7xm2" }, { "sim":316.0, - "partner":"7xm5" + "partner":"7xm3" }, { "sim":316.0, - "partner":"7xot" + "partner":"7xm4" }, { "sim":316.0, - "partner":"7xm2" + "partner":"7xm5" }, { "sim":316.0, @@ -764784,25 +767847,17 @@ "sim":312.0, "partner":"6zez" }, - { - "sim":312.0, - "partner":"5fnq" - }, { "sim":312.0, "partner":"6zf0" }, - { - "sim":312.0, - "partner":"5fnr" - }, { "sim":312.0, "partner":"6zf1" }, { "sim":312.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":312.0, @@ -764810,7 +767865,7 @@ }, { "sim":312.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":312.0, @@ -764818,19 +767873,23 @@ }, { "sim":312.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":312.0, "partner":"6zf4" }, + { + "sim":312.0, + "partner":"5fnt" + }, { "sim":312.0, "partner":"6zf5" }, { "sim":312.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":312.0, @@ -764840,6 +767899,10 @@ "sim":312.0, "partner":"6zf7" }, + { + "sim":312.0, + "partner":"5fzj" + }, { "sim":312.0, "partner":"6zf8" @@ -764856,10 +767919,6 @@ "sim":312.0, "partner":"3zgd" }, - { - "sim":312.0, - "partner":"1x2j" - }, { "sim":312.0, "partner":"1x2r" @@ -764880,6 +767939,10 @@ "sim":312.0, "partner":"8pkx" }, + { + "sim":312.0, + "partner":"1x2j" + }, { "sim":312.0, "partner":"2z32" @@ -764962,23 +768025,23 @@ }, { "sim":312.0, - "partner":"5wg1" + "partner":"8ehv" }, { "sim":312.0, - "partner":"8ehv" + "partner":"5wg1" }, { "sim":312.0, - "partner":"5who" + "partner":"8ejr" }, { "sim":312.0, - "partner":"5wfl" + "partner":"5who" }, { "sim":312.0, - "partner":"8ejr" + "partner":"5wfl" }, { "sim":312.0, @@ -764988,10 +768051,6 @@ "sim":312.0, "partner":"8in0" }, - { - "sim":311.0, - "partner":"7k2r" - }, { "sim":311.0, "partner":"7k28" @@ -765018,11 +768077,11 @@ }, { "sim":311.0, - "partner":"7ofe" + "partner":"7k2r" }, { "sim":311.0, - "partner":"7q5h" + "partner":"7ofe" }, { "sim":311.0, @@ -765046,7 +768105,7 @@ }, { "sim":311.0, - "partner":"7k2g" + "partner":"7q5h" }, { "sim":311.0, @@ -765068,6 +768127,10 @@ "sim":311.0, "partner":"7k2e" }, + { + "sim":311.0, + "partner":"7k2g" + }, { "sim":310.0, "partner":"7k2l" @@ -765078,15 +768141,15 @@ }, { "sim":310.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":310.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":310.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":270.0, @@ -765106,7 +768169,7 @@ }, { "sim":251.0, - "partner":"8rbh" + "partner":"8oio" }, { "sim":251.0, @@ -765118,11 +768181,11 @@ }, { "sim":251.0, - "partner":"8oio" + "partner":"6ttk" }, { "sim":251.0, - "partner":"6ttk" + "partner":"8rbh" }, { "sim":239.0, @@ -765134,11 +768197,11 @@ }, { "sim":235.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":235.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":223.0, @@ -765154,19 +768217,19 @@ }, { "sim":156.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":156.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":146.0, - "partner":"8khp" + "partner":"8w4j" }, { "sim":146.0, - "partner":"8w4j" + "partner":"8khp" }, { "sim":146.0, @@ -765342,12 +768405,12 @@ ], "subtitle":"Crystal structure of the computationally designed sake6fr protein", "tags":[ - "propeller", - "scaffold", - "computational", "design", + "unknown function", + "propeller", "kelch", - "unknown function" + "computational", + "scaffold" ], "keywords":[ "description", @@ -765424,11 +768487,11 @@ }, { "sim":392.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":392.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":392.0, @@ -765476,10 +768539,6 @@ "sim":400.0, "partner":"8p2u" }, - { - "sim":299.0, - "partner":"4l7d" - }, { "sim":299.0, "partner":"4l7b" @@ -765492,6 +768551,10 @@ "sim":299.0, "partner":"4n1b" }, + { + "sim":299.0, + "partner":"4l7d" + }, { "sim":297.0, "partner":"8x34" @@ -765510,43 +768573,43 @@ }, { "sim":297.0, - "partner":"5x54" + "partner":"4ifj" }, { "sim":297.0, - "partner":"6rog" + "partner":"4ifl" }, { "sim":297.0, - "partner":"4ifj" + "partner":"4ifn" }, { "sim":297.0, - "partner":"4ifl" + "partner":"5x54" }, { "sim":297.0, - "partner":"4ifn" + "partner":"6rog" }, { "sim":297.0, - "partner":"7xm3" + "partner":"7xot" }, { "sim":297.0, - "partner":"7xm4" + "partner":"7xm2" }, { "sim":297.0, - "partner":"7xm5" + "partner":"7xm3" }, { "sim":297.0, - "partner":"7xot" + "partner":"7xm4" }, { "sim":297.0, - "partner":"7xm2" + "partner":"7xm5" }, { "sim":297.0, @@ -765610,23 +768673,23 @@ }, { "sim":297.0, - "partner":"8ivr" + "partner":"8ivg" }, { "sim":297.0, - "partner":"8xgv" + "partner":"8ixs" }, { "sim":297.0, - "partner":"8ivg" + "partner":"8xgk" }, { "sim":297.0, - "partner":"8ixs" + "partner":"8ivr" }, { "sim":297.0, - "partner":"8xgk" + "partner":"8xgv" }, { "sim":297.0, @@ -765652,10 +768715,6 @@ "sim":291.0, "partner":"7k2m" }, - { - "sim":291.0, - "partner":"7k2r" - }, { "sim":291.0, "partner":"7k28" @@ -765680,6 +768739,10 @@ "sim":291.0, "partner":"7k2q" }, + { + "sim":291.0, + "partner":"7k2r" + }, { "sim":291.0, "partner":"6sp1" @@ -765696,10 +768759,6 @@ "sim":291.0, "partner":"6sp4" }, - { - "sim":291.0, - "partner":"7q5h" - }, { "sim":291.0, "partner":"6z6a" @@ -765722,11 +768781,11 @@ }, { "sim":291.0, - "partner":"4iqk" + "partner":"7q5h" }, { "sim":291.0, - "partner":"7k2g" + "partner":"4iqk" }, { "sim":291.0, @@ -765752,6 +768811,10 @@ "sim":291.0, "partner":"7k2e" }, + { + "sim":291.0, + "partner":"7k2g" + }, { "sim":291.0, "partner":"3zgc" @@ -765790,23 +768853,23 @@ }, { "sim":291.0, - "partner":"5wg1" + "partner":"8ehv" }, { "sim":291.0, - "partner":"8ehv" + "partner":"5wg1" }, { "sim":291.0, - "partner":"5who" + "partner":"8ejr" }, { "sim":291.0, - "partner":"5wfl" + "partner":"5who" }, { "sim":291.0, - "partner":"8ejr" + "partner":"5wfl" }, { "sim":291.0, @@ -765872,25 +768935,17 @@ "sim":290.0, "partner":"6zez" }, - { - "sim":290.0, - "partner":"5fnq" - }, { "sim":290.0, "partner":"6zf0" }, - { - "sim":290.0, - "partner":"5fnr" - }, { "sim":290.0, "partner":"6zf1" }, { "sim":290.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":290.0, @@ -765898,7 +768953,7 @@ }, { "sim":290.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":290.0, @@ -765906,19 +768961,23 @@ }, { "sim":290.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":290.0, "partner":"6zf4" }, + { + "sim":290.0, + "partner":"5fnt" + }, { "sim":290.0, "partner":"6zf5" }, { "sim":290.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":290.0, @@ -765928,6 +768987,10 @@ "sim":290.0, "partner":"6zf7" }, + { + "sim":290.0, + "partner":"5fzj" + }, { "sim":290.0, "partner":"6zf8" @@ -765954,11 +769017,11 @@ }, { "sim":290.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":290.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":290.0, @@ -766034,15 +769097,15 @@ }, { "sim":289.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":289.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":289.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":269.0, @@ -766062,7 +769125,7 @@ }, { "sim":237.0, - "partner":"8rbh" + "partner":"8oio" }, { "sim":237.0, @@ -766074,11 +769137,11 @@ }, { "sim":237.0, - "partner":"8oio" + "partner":"6ttk" }, { "sim":237.0, - "partner":"6ttk" + "partner":"8rbh" }, { "sim":233.0, @@ -766094,11 +769157,11 @@ }, { "sim":226.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":226.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":216.0, @@ -766110,19 +769173,19 @@ }, { "sim":156.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":156.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":132.0, - "partner":"8khp" + "partner":"8w4j" }, { "sim":132.0, - "partner":"8w4j" + "partner":"8khp" }, { "sim":132.0, @@ -766290,12 +769353,12 @@ ], "subtitle":"Crystal structure of the computationally designed sake6eeref protein", "tags":[ - "propeller", - "scaffold", - "computational", "design", + "unknown function", + "propeller", "kelch", - "unknown function" + "computational", + "scaffold" ], "keywords":[ "description", @@ -766376,11 +769439,11 @@ }, { "sim":447.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":447.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":447.0, @@ -766424,10 +769487,6 @@ "sim":454.0, "partner":"8p2u" }, - { - "sim":297.0, - "partner":"4l7d" - }, { "sim":297.0, "partner":"4l7b" @@ -766440,6 +769499,10 @@ "sim":297.0, "partner":"4n1b" }, + { + "sim":297.0, + "partner":"4l7d" + }, { "sim":295.0, "partner":"8x34" @@ -766458,43 +769521,43 @@ }, { "sim":295.0, - "partner":"5x54" + "partner":"4ifj" }, { "sim":295.0, - "partner":"6rog" + "partner":"4ifl" }, { "sim":295.0, - "partner":"4ifj" + "partner":"4ifn" }, { "sim":295.0, - "partner":"4ifl" + "partner":"5x54" }, { "sim":295.0, - "partner":"4ifn" + "partner":"6rog" }, { "sim":295.0, - "partner":"7xm3" + "partner":"7xot" }, { "sim":295.0, - "partner":"7xm4" + "partner":"7xm2" }, { "sim":295.0, - "partner":"7xm5" + "partner":"7xm3" }, { "sim":295.0, - "partner":"7xot" + "partner":"7xm4" }, { "sim":295.0, - "partner":"7xm2" + "partner":"7xm5" }, { "sim":295.0, @@ -766558,23 +769621,23 @@ }, { "sim":295.0, - "partner":"8ivr" + "partner":"8ivg" }, { "sim":295.0, - "partner":"8xgv" + "partner":"8ixs" }, { "sim":295.0, - "partner":"8ivg" + "partner":"8xgk" }, { "sim":295.0, - "partner":"8ixs" + "partner":"8ivr" }, { "sim":295.0, - "partner":"8xgk" + "partner":"8xgv" }, { "sim":295.0, @@ -766672,25 +769735,17 @@ "sim":292.0, "partner":"6zez" }, - { - "sim":292.0, - "partner":"5fnq" - }, { "sim":292.0, "partner":"6zf0" }, - { - "sim":292.0, - "partner":"5fnr" - }, { "sim":292.0, "partner":"6zf1" }, { "sim":292.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":292.0, @@ -766698,7 +769753,7 @@ }, { "sim":292.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":292.0, @@ -766706,19 +769761,23 @@ }, { "sim":292.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":292.0, "partner":"6zf4" }, + { + "sim":292.0, + "partner":"5fnt" + }, { "sim":292.0, "partner":"6zf5" }, { "sim":292.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":292.0, @@ -766728,6 +769787,10 @@ "sim":292.0, "partner":"6zf7" }, + { + "sim":292.0, + "partner":"5fzj" + }, { "sim":292.0, "partner":"6zf8" @@ -766810,11 +769873,11 @@ }, { "sim":291.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":291.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":291.0, @@ -766848,10 +769911,6 @@ "sim":290.0, "partner":"5yq4" }, - { - "sim":290.0, - "partner":"7k2g" - }, { "sim":290.0, "partner":"7k2s" @@ -766878,7 +769937,7 @@ }, { "sim":290.0, - "partner":"4zy3" + "partner":"7k2g" }, { "sim":290.0, @@ -766888,6 +769947,10 @@ "sim":290.0, "partner":"3wn7" }, + { + "sim":290.0, + "partner":"4zy3" + }, { "sim":290.0, "partner":"8pku" @@ -766918,23 +769981,23 @@ }, { "sim":290.0, - "partner":"5wg1" + "partner":"8ehv" }, { "sim":290.0, - "partner":"8ehv" + "partner":"5wg1" }, { "sim":290.0, - "partner":"5who" + "partner":"8ejr" }, { "sim":290.0, - "partner":"5wfl" + "partner":"5who" }, { "sim":290.0, - "partner":"8ejr" + "partner":"5wfl" }, { "sim":290.0, @@ -766948,10 +770011,6 @@ "sim":289.0, "partner":"7k2m" }, - { - "sim":289.0, - "partner":"7k2r" - }, { "sim":289.0, "partner":"7k28" @@ -766978,7 +770037,7 @@ }, { "sim":289.0, - "partner":"7q5h" + "partner":"7k2r" }, { "sim":289.0, @@ -767000,6 +770059,10 @@ "sim":289.0, "partner":"7q6s" }, + { + "sim":289.0, + "partner":"7q5h" + }, { "sim":289.0, "partner":"6gy5" @@ -767010,15 +770073,15 @@ }, { "sim":250.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":250.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":249.0, - "partner":"8rbh" + "partner":"8oio" }, { "sim":249.0, @@ -767030,11 +770093,11 @@ }, { "sim":249.0, - "partner":"8oio" + "partner":"6ttk" }, { "sim":249.0, - "partner":"6ttk" + "partner":"8rbh" }, { "sim":248.0, @@ -767058,11 +770121,11 @@ }, { "sim":146.0, - "partner":"8khp" + "partner":"8w4j" }, { "sim":146.0, - "partner":"8w4j" + "partner":"8khp" }, { "sim":146.0, @@ -767070,11 +770133,11 @@ }, { "sim":145.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":145.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":133.0, @@ -767250,12 +770313,12 @@ ], "subtitle":"Crystal structure of the computationally designed sake6eetal protein", "tags":[ - "propeller", - "scaffold", - "computational", "design", + "unknown function", + "propeller", "kelch", - "unknown function" + "computational", + "scaffold" ], "keywords":[ "description", @@ -767340,11 +770403,11 @@ }, { "sim":484.0, - "partner":"7opu" + "partner":"7opv" }, { "sim":484.0, - "partner":"7opv" + "partner":"7opu" }, { "sim":484.0, @@ -767384,15 +770447,15 @@ }, { "sim":61.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":61.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":61.0, - "partner":"7ax2" + "partner":"7ax0" } ], "seq_thr_sim_natural":[ @@ -767456,14 +770519,6 @@ "sim":299.0, "partner":"6hws" }, - { - "sim":299.0, - "partner":"5x54" - }, - { - "sim":299.0, - "partner":"6rog" - }, { "sim":299.0, "partner":"4ifj" @@ -767478,27 +770533,31 @@ }, { "sim":299.0, - "partner":"7xm3" + "partner":"5x54" }, { "sim":299.0, - "partner":"7xm4" + "partner":"6rog" }, { "sim":299.0, - "partner":"7xm5" + "partner":"7xot" }, { "sim":299.0, - "partner":"7xot" + "partner":"7xm2" }, { "sim":299.0, - "partner":"7xm2" + "partner":"7xm3" }, { "sim":299.0, - "partner":"4l7d" + "partner":"7xm4" + }, + { + "sim":299.0, + "partner":"7xm5" }, { "sim":299.0, @@ -767512,6 +770571,10 @@ "sim":299.0, "partner":"4n1b" }, + { + "sim":299.0, + "partner":"4l7d" + }, { "sim":299.0, "partner":"7k2h" @@ -767546,23 +770609,23 @@ }, { "sim":299.0, - "partner":"8ivr" + "partner":"8ivg" }, { "sim":299.0, - "partner":"8xgv" + "partner":"8ixs" }, { "sim":299.0, - "partner":"8ivg" + "partner":"8xgk" }, { "sim":299.0, - "partner":"8ixs" + "partner":"8ivr" }, { "sim":299.0, - "partner":"8xgk" + "partner":"8xgv" }, { "sim":299.0, @@ -767602,11 +770665,11 @@ }, { "sim":297.0, - "partner":"1x2j" + "partner":"1x2r" }, { "sim":297.0, - "partner":"1x2r" + "partner":"1x2j" }, { "sim":297.0, @@ -767684,25 +770747,17 @@ "sim":296.0, "partner":"6zez" }, - { - "sim":296.0, - "partner":"5fnq" - }, { "sim":296.0, "partner":"6zf0" }, - { - "sim":296.0, - "partner":"5fnr" - }, { "sim":296.0, "partner":"6zf1" }, { "sim":296.0, - "partner":"5fns" + "partner":"5fnq" }, { "sim":296.0, @@ -767710,7 +770765,7 @@ }, { "sim":296.0, - "partner":"5fnt" + "partner":"5fnr" }, { "sim":296.0, @@ -767718,19 +770773,23 @@ }, { "sim":296.0, - "partner":"5fnu" + "partner":"5fns" }, { "sim":296.0, "partner":"6zf4" }, + { + "sim":296.0, + "partner":"5fnt" + }, { "sim":296.0, "partner":"6zf5" }, { "sim":296.0, - "partner":"5fzj" + "partner":"5fnu" }, { "sim":296.0, @@ -767740,6 +770799,10 @@ "sim":296.0, "partner":"6zf7" }, + { + "sim":296.0, + "partner":"5fzj" + }, { "sim":296.0, "partner":"6zf8" @@ -767806,15 +770869,15 @@ }, { "sim":295.0, - "partner":"4zy3" + "partner":"3wdz" }, { "sim":295.0, - "partner":"3wdz" + "partner":"3wn7" }, { "sim":295.0, - "partner":"3wn7" + "partner":"4zy3" }, { "sim":294.0, @@ -767870,23 +770933,23 @@ }, { "sim":294.0, - "partner":"5wg1" + "partner":"8ehv" }, { "sim":294.0, - "partner":"8ehv" + "partner":"5wg1" }, { "sim":294.0, - "partner":"5who" + "partner":"8ejr" }, { "sim":294.0, - "partner":"5wfl" + "partner":"5who" }, { "sim":294.0, - "partner":"8ejr" + "partner":"5wfl" }, { "sim":294.0, @@ -767900,10 +770963,6 @@ "sim":293.0, "partner":"7k2m" }, - { - "sim":293.0, - "partner":"7k2r" - }, { "sim":293.0, "partner":"7k28" @@ -767930,7 +770989,7 @@ }, { "sim":293.0, - "partner":"7q5h" + "partner":"7k2r" }, { "sim":293.0, @@ -767954,7 +771013,7 @@ }, { "sim":293.0, - "partner":"7k2g" + "partner":"7q5h" }, { "sim":293.0, @@ -767980,13 +771039,17 @@ "sim":293.0, "partner":"7k2e" }, + { + "sim":293.0, + "partner":"7k2g" + }, { "sim":269.0, "partner":"6hrl" }, { "sim":265.0, - "partner":"8rbh" + "partner":"8oio" }, { "sim":265.0, @@ -767998,11 +771061,11 @@ }, { "sim":265.0, - "partner":"8oio" + "partner":"6ttk" }, { "sim":265.0, - "partner":"6ttk" + "partner":"8rbh" }, { "sim":260.0, @@ -768014,11 +771077,11 @@ }, { "sim":246.0, - "partner":"2xn4" + "partner":"4chb" }, { "sim":246.0, - "partner":"4chb" + "partner":"2xn4" }, { "sim":240.0, @@ -768034,19 +771097,19 @@ }, { "sim":167.0, - "partner":"4yy8" + "partner":"4zgc" }, { "sim":167.0, - "partner":"4zgc" + "partner":"4yy8" }, { "sim":152.0, - "partner":"8khp" + "partner":"8w4j" }, { "sim":152.0, - "partner":"8w4j" + "partner":"8khp" }, { "sim":152.0, @@ -768246,12 +771309,12 @@ ], "subtitle":"The structure of v13bagel2", "tags":[ + "self-assembly", + "biosynthetic protein", "assembly", "symmetric", "beta-propeller", - "protein design", - "biosynthetic protein", - "self-assembly" + "protein design" ], "keywords":[ "description", @@ -768300,15 +771363,15 @@ }, { "sim":158.0, - "partner":"8prr" + "partner":"8prf" }, { "sim":158.0, - "partner":"8pre" + "partner":"8prr" }, { "sim":158.0, - "partner":"8prf" + "partner":"8pre" }, { "sim":157.0, @@ -768352,15 +771415,15 @@ }, { "sim":97.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":97.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":97.0, - "partner":"7ax2" + "partner":"7ax0" } ], "seq_thr_sim_natural":[ @@ -768378,35 +771441,35 @@ }, { "sim":158.0, - "partner":"8prp" + "partner":"8prg" }, { "sim":158.0, - "partner":"8prq" + "partner":"8prh" }, { "sim":158.0, - "partner":"8prt" + "partner":"8pri" }, { "sim":158.0, - "partner":"8prd" + "partner":"8prm" }, { "sim":158.0, - "partner":"8prg" + "partner":"8prp" }, { "sim":158.0, - "partner":"8prh" + "partner":"8prq" }, { "sim":158.0, - "partner":"8pri" + "partner":"8prt" }, { "sim":158.0, - "partner":"8prm" + "partner":"8prd" }, { "sim":101.0, @@ -768534,12 +771597,12 @@ ], "subtitle":"The structure of v13bagel4", "tags":[ + "self-assembly", + "biosynthetic protein", "assembly", "symmetric", "beta-propeller", - "protein design", - "biosynthetic protein", - "self-assembly" + "protein design" ], "keywords":[ "description", @@ -768620,27 +771683,27 @@ }, { "sim":185.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":185.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":185.0, - "partner":"7ax2" + "partner":"7ax0" }, { "sim":180.0, - "partner":"8prr" + "partner":"8prf" }, { "sim":180.0, - "partner":"8pre" + "partner":"8prr" }, { "sim":180.0, - "partner":"8prf" + "partner":"8pre" }, { "sim":179.0, @@ -768666,35 +771729,35 @@ }, { "sim":180.0, - "partner":"8prp" + "partner":"8prg" }, { "sim":180.0, - "partner":"8prq" + "partner":"8prh" }, { "sim":180.0, - "partner":"8prt" + "partner":"8pri" }, { "sim":180.0, - "partner":"8prd" + "partner":"8prm" }, { "sim":180.0, - "partner":"8prg" + "partner":"8prp" }, { "sim":180.0, - "partner":"8prh" + "partner":"8prq" }, { "sim":180.0, - "partner":"8pri" + "partner":"8prt" }, { "sim":180.0, - "partner":"8prm" + "partner":"8prd" }, { "sim":179.0, @@ -768794,12 +771857,12 @@ ], "subtitle":"The structure of v13bagel6", "tags":[ + "self-assembly", + "biosynthetic protein", "assembly", "symmetric", "beta-propeller", - "protein design", - "biosynthetic protein", - "self-assembly" + "protein design" ], "keywords":[ "description", @@ -768848,15 +771911,15 @@ }, { "sim":158.0, - "partner":"8prr" + "partner":"8prf" }, { "sim":158.0, - "partner":"8pre" + "partner":"8prr" }, { "sim":158.0, - "partner":"8prf" + "partner":"8pre" }, { "sim":157.0, @@ -768900,15 +771963,15 @@ }, { "sim":97.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":97.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":97.0, - "partner":"7ax2" + "partner":"7ax0" } ], "seq_thr_sim_natural":[ @@ -768926,35 +771989,35 @@ }, { "sim":158.0, - "partner":"8prp" + "partner":"8prg" }, { "sim":158.0, - "partner":"8prq" + "partner":"8prh" }, { "sim":158.0, - "partner":"8prt" + "partner":"8pri" }, { "sim":158.0, - "partner":"8prd" + "partner":"8prm" }, { "sim":158.0, - "partner":"8prg" + "partner":"8prp" }, { "sim":158.0, - "partner":"8prh" + "partner":"8prq" }, { "sim":158.0, - "partner":"8pri" + "partner":"8prt" }, { "sim":158.0, - "partner":"8prm" + "partner":"8prd" }, { "sim":101.0, @@ -769070,12 +772133,12 @@ ], "subtitle":"The structure of nvbagel2 in the presence of zn(ii)", "tags":[ + "self-assembly", + "biosynthetic protein", "assembly", "symmetric", "beta-propeller", - "protein design", - "biosynthetic protein", - "self-assembly" + "protein design" ], "keywords":[ "description", @@ -769110,278 +772173,14 @@ "previous_design":"8prb", "next_design":"8prf", "seq_thr_sim_designed":[ - { - "sim":187.0, - "partner":"8prr" - }, { "sim":187.0, "partner":"8prf" }, - { - "sim":181.0, - "partner":"8pra" - }, - { - "sim":180.0, - "partner":"8prj" - }, - { - "sim":159.0, - "partner":"8prb" - }, - { - "sim":159.0, - "partner":"8pr9" - }, - { - "sim":136.0, - "partner":"8prl" - }, - { - "sim":124.0, - "partner":"6tjc" - }, - { - "sim":124.0, - "partner":"6tjd" - }, - { - "sim":124.0, - "partner":"6tje" - }, - { - "sim":124.0, - "partner":"6tjf" - }, - { - "sim":124.0, - "partner":"6tjg" - }, - { - "sim":124.0, - "partner":"6tjh" - }, - { - "sim":123.0, - "partner":"6tji" - }, - { - "sim":113.0, - "partner":"6tjb" - }, - { - "sim":104.0, - "partner":"7awy" - }, - { - "sim":97.0, - "partner":"7ax0" - }, - { - "sim":97.0, - "partner":"7awz" - }, - { - "sim":97.0, - "partner":"7ax2" - } - ], - "seq_thr_sim_natural":[ - { - "sim":187.0, - "partner":"8prp" - }, - { - "sim":187.0, - "partner":"8prq" - }, - { - "sim":187.0, - "partner":"8prt" - }, - { - "sim":187.0, - "partner":"8prd" - }, - { - "sim":187.0, - "partner":"8prg" - }, - { - "sim":187.0, - "partner":"8prh" - }, - { - "sim":187.0, - "partner":"8pri" - }, - { - "sim":187.0, - "partner":"8prm" - }, - { - "sim":187.0, - "partner":"8prs" - }, - { - "sim":179.0, - "partner":"8pro" - }, - { - "sim":159.0, - "partner":"8prc" - }, - { - "sim":102.0, - "partner":"3hxj" - }, - { - "sim":75.0, - "partner":"7eq5" - }, - { - "sim":73.0, - "partner":"7evf" - }, - { - "sim":73.0, - "partner":"7dxn" - } - ], - "struct_thr_sim_designed":[ - { - "sim":0.986100018, - "partner":"8prr" - }, - { - "sim":0.978399992, - "partner":"8prf" - }, - { - "sim":0.9869999886, - "partner":"8pra" - }, - { - "sim":0.9901000261, - "partner":"8prj" - }, - { - "sim":0.9585000277, - "partner":"6tjg" - }, - { - "sim":0.9650999904, - "partner":"6tjd" - } - ], - "struct_thr_sim_natural":[ - - ], - "seq_max_sim_designed":{ - "sim":187.0, - "partner":"8prr" - }, - "seq_max_sim_natural":{ - "sim":187.0, - "partner":"8prp" - }, - "struct_max_sim_designed":{ - "sim":0.9901000261, - "partner":"8prj" - }, - "struct_max_sim_natural":{ - "sim":0.9107000232, - "partner":"3hxj" - }, - "review_comment":[ - "" - ] - }, - { - "pdb":"8prf", - "picture_path":"https:\/\/cdn.rcsb.org\/images\/structures\/8prf_assembly-1.jpeg", - "chains":[ - { - "chain_id":"A", - "chain_source":"synthetic construct", - "chain_type":"D", - "chain_seq_unnat":"GSHMTGGSVHSSPAIGQDGTIYVGSNDHYLYAINPNGKLKWKFETGGSVHSSPAIGQDGTIYVGSNDHYLYAINPNGKLKWKFE", - "chain_seq_nat":"GSHMTGGSVHSSPAIGQDGTIYVGSNDHYLYAINPNGKLKWKFETGGSVHSSPAIGQDGTIYVGSNDHYLYAINPNGKLKWKFE", - "chain_length":85 - } - ], - "authors":[ - { - "forename":"L.", - "surname":"Vandebroek" - }, - { - "forename":"A.R.D.", - "surname":"Voet" - }, - { - "forename":"X.Y.", - "surname":"Lee" - } - ], - "classification":"unknown", - "classification_suggested":[ - - ], - "classification_suggested_reason":[ - - ], - "subtitle":"The structure of nvbagel5", - "tags":[ - "assembly", - "symmetric", - "beta-propeller", - "protein design", - "biosynthetic protein", - "self-assembly" - ], - "keywords":[ - "description", - "found" - ], - "release_date":"2024-07-24", - "publication":"To be published", - "publication_ref":{ - "DOI":"", - "PubMed":"", - "CSD":"", - "ISSN":"", - "ASTM":"" - }, - "publication_country":"", - "abstract":"No description found.", - "crystal_structure":{ - "length_a":"56.183", - "length_b":"56.183", - "length_c":"109.806", - "angle_a":"90.00", - "angle_b":"90.00", - "angle_g":"90.00" - }, - "symmetry":"I 4 2 2", - "exptl_method":[ - "X-RAY DIFFRACTION" - ], - "formula_weight":9050.947, - "synthesis_comment":"", - "review":true, - "previous_design":"8pre", - "next_design":"8prj", - "seq_thr_sim_designed":[ { "sim":187.0, "partner":"8prr" }, - { - "sim":187.0, - "partner":"8pre" - }, { "sim":181.0, "partner":"8pra" @@ -769440,18 +772239,34 @@ }, { "sim":97.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":97.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":97.0, - "partner":"7ax2" + "partner":"7ax0" } ], "seq_thr_sim_natural":[ + { + "sim":187.0, + "partner":"8prg" + }, + { + "sim":187.0, + "partner":"8prh" + }, + { + "sim":187.0, + "partner":"8pri" + }, + { + "sim":187.0, + "partner":"8prm" + }, { "sim":187.0, "partner":"8prp" @@ -769468,6 +772283,238 @@ "sim":187.0, "partner":"8prd" }, + { + "sim":187.0, + "partner":"8prs" + }, + { + "sim":179.0, + "partner":"8pro" + }, + { + "sim":159.0, + "partner":"8prc" + }, + { + "sim":102.0, + "partner":"3hxj" + }, + { + "sim":75.0, + "partner":"7eq5" + }, + { + "sim":73.0, + "partner":"7evf" + }, + { + "sim":73.0, + "partner":"7dxn" + } + ], + "struct_thr_sim_designed":[ + { + "sim":0.986100018, + "partner":"8prr" + }, + { + "sim":0.978399992, + "partner":"8prf" + }, + { + "sim":0.9869999886, + "partner":"8pra" + }, + { + "sim":0.9901000261, + "partner":"8prj" + }, + { + "sim":0.9585000277, + "partner":"6tjg" + }, + { + "sim":0.9650999904, + "partner":"6tjd" + } + ], + "struct_thr_sim_natural":[ + + ], + "seq_max_sim_designed":{ + "sim":187.0, + "partner":"8prf" + }, + "seq_max_sim_natural":{ + "sim":187.0, + "partner":"8prg" + }, + "struct_max_sim_designed":{ + "sim":0.9901000261, + "partner":"8prj" + }, + "struct_max_sim_natural":{ + "sim":0.9107000232, + "partner":"3hxj" + }, + "review_comment":[ + "" + ] + }, + { + "pdb":"8prf", + "picture_path":"https:\/\/cdn.rcsb.org\/images\/structures\/8prf_assembly-1.jpeg", + "chains":[ + { + "chain_id":"A", + "chain_source":"synthetic construct", + "chain_type":"D", + "chain_seq_unnat":"GSHMTGGSVHSSPAIGQDGTIYVGSNDHYLYAINPNGKLKWKFETGGSVHSSPAIGQDGTIYVGSNDHYLYAINPNGKLKWKFE", + "chain_seq_nat":"GSHMTGGSVHSSPAIGQDGTIYVGSNDHYLYAINPNGKLKWKFETGGSVHSSPAIGQDGTIYVGSNDHYLYAINPNGKLKWKFE", + "chain_length":85 + } + ], + "authors":[ + { + "forename":"L.", + "surname":"Vandebroek" + }, + { + "forename":"A.R.D.", + "surname":"Voet" + }, + { + "forename":"X.Y.", + "surname":"Lee" + } + ], + "classification":"unknown", + "classification_suggested":[ + + ], + "classification_suggested_reason":[ + + ], + "subtitle":"The structure of nvbagel5", + "tags":[ + "self-assembly", + "biosynthetic protein", + "assembly", + "symmetric", + "beta-propeller", + "protein design" + ], + "keywords":[ + "description", + "found" + ], + "release_date":"2024-07-24", + "publication":"To be published", + "publication_ref":{ + "DOI":"", + "PubMed":"", + "CSD":"", + "ISSN":"", + "ASTM":"" + }, + "publication_country":"", + "abstract":"No description found.", + "crystal_structure":{ + "length_a":"56.183", + "length_b":"56.183", + "length_c":"109.806", + "angle_a":"90.00", + "angle_b":"90.00", + "angle_g":"90.00" + }, + "symmetry":"I 4 2 2", + "exptl_method":[ + "X-RAY DIFFRACTION" + ], + "formula_weight":9050.947, + "synthesis_comment":"", + "review":true, + "previous_design":"8pre", + "next_design":"8prj", + "seq_thr_sim_designed":[ + { + "sim":187.0, + "partner":"8prr" + }, + { + "sim":187.0, + "partner":"8pre" + }, + { + "sim":181.0, + "partner":"8pra" + }, + { + "sim":180.0, + "partner":"8prj" + }, + { + "sim":159.0, + "partner":"8prb" + }, + { + "sim":159.0, + "partner":"8pr9" + }, + { + "sim":136.0, + "partner":"8prl" + }, + { + "sim":124.0, + "partner":"6tjc" + }, + { + "sim":124.0, + "partner":"6tjd" + }, + { + "sim":124.0, + "partner":"6tje" + }, + { + "sim":124.0, + "partner":"6tjf" + }, + { + "sim":124.0, + "partner":"6tjg" + }, + { + "sim":124.0, + "partner":"6tjh" + }, + { + "sim":123.0, + "partner":"6tji" + }, + { + "sim":113.0, + "partner":"6tjb" + }, + { + "sim":104.0, + "partner":"7awy" + }, + { + "sim":97.0, + "partner":"7awz" + }, + { + "sim":97.0, + "partner":"7ax2" + }, + { + "sim":97.0, + "partner":"7ax0" + } + ], + "seq_thr_sim_natural":[ { "sim":187.0, "partner":"8prg" @@ -769484,6 +772531,22 @@ "sim":187.0, "partner":"8prm" }, + { + "sim":187.0, + "partner":"8prp" + }, + { + "sim":187.0, + "partner":"8prq" + }, + { + "sim":187.0, + "partner":"8prt" + }, + { + "sim":187.0, + "partner":"8prd" + }, { "sim":187.0, "partner":"8prs" @@ -769568,7 +772631,7 @@ }, "seq_max_sim_natural":{ "sim":187.0, - "partner":"8prp" + "partner":"8prg" }, "struct_max_sim_designed":{ "sim":0.9965000153, @@ -769618,12 +772681,12 @@ ], "subtitle":"The structure of v31bagel8", "tags":[ + "self-assembly", + "biosynthetic protein", "assembly", "symmetric", "beta-propeller", - "protein design", - "biosynthetic protein", - "self-assembly" + "protein design" ], "keywords":[ "description", @@ -769684,15 +772747,15 @@ }, { "sim":352.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":352.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":352.0, - "partner":"7ax2" + "partner":"7ax0" }, { "sim":300.0, @@ -769712,15 +772775,15 @@ }, { "sim":179.0, - "partner":"8prr" + "partner":"8prf" }, { "sim":179.0, - "partner":"8pre" + "partner":"8prr" }, { "sim":179.0, - "partner":"8prf" + "partner":"8pre" }, { "sim":179.0, @@ -769762,35 +772825,35 @@ }, { "sim":179.0, - "partner":"8prp" + "partner":"8prg" }, { "sim":179.0, - "partner":"8prq" + "partner":"8prh" }, { "sim":179.0, - "partner":"8prt" + "partner":"8pri" }, { "sim":179.0, - "partner":"8prd" + "partner":"8prm" }, { "sim":179.0, - "partner":"8prg" + "partner":"8prp" }, { "sim":179.0, - "partner":"8prh" + "partner":"8prq" }, { "sim":179.0, - "partner":"8pri" + "partner":"8prt" }, { "sim":179.0, - "partner":"8prm" + "partner":"8prd" }, { "sim":179.0, @@ -769875,12 +772938,12 @@ ], "subtitle":"The structure of v22bagel8", "tags":[ + "self-assembly", + "biosynthetic protein", "assembly", "symmetric", "beta-propeller", - "protein design", - "biosynthetic protein", - "self-assembly" + "protein design" ], "keywords":[ "description", @@ -769933,15 +772996,15 @@ }, { "sim":136.0, - "partner":"8prr" + "partner":"8prf" }, { "sim":136.0, - "partner":"8pre" + "partner":"8prr" }, { "sim":136.0, - "partner":"8prf" + "partner":"8pre" }, { "sim":123.0, @@ -769981,15 +773044,15 @@ }, { "sim":102.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":102.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":102.0, - "partner":"7ax2" + "partner":"7ax0" } ], "seq_thr_sim_natural":[ @@ -770007,35 +773070,35 @@ }, { "sim":136.0, - "partner":"8prp" + "partner":"8prg" }, { "sim":136.0, - "partner":"8prq" + "partner":"8prh" }, { "sim":136.0, - "partner":"8prt" + "partner":"8pri" }, { "sim":136.0, - "partner":"8prd" + "partner":"8prm" }, { "sim":136.0, - "partner":"8prg" + "partner":"8prp" }, { "sim":136.0, - "partner":"8prh" + "partner":"8prq" }, { "sim":136.0, - "partner":"8pri" + "partner":"8prt" }, { "sim":136.0, - "partner":"8prm" + "partner":"8prd" }, { "sim":108.0, @@ -770131,12 +773194,12 @@ ], "subtitle":"The structure of nvbagel4 in the presence of co(ii)", "tags":[ + "self-assembly", + "biosynthetic protein", "assembly", "symmetric", "beta-propeller", - "protein design", - "biosynthetic protein", - "self-assembly" + "protein design" ], "keywords":[ "description", @@ -770173,11 +773236,11 @@ "seq_thr_sim_designed":[ { "sim":187.0, - "partner":"8pre" + "partner":"8prf" }, { "sim":187.0, - "partner":"8prf" + "partner":"8pre" }, { "sim":181.0, @@ -770237,49 +773300,49 @@ }, { "sim":97.0, - "partner":"7ax0" + "partner":"7awz" }, { "sim":97.0, - "partner":"7awz" + "partner":"7ax2" }, { "sim":97.0, - "partner":"7ax2" + "partner":"7ax0" } ], "seq_thr_sim_natural":[ { "sim":187.0, - "partner":"8prp" + "partner":"8prg" }, { "sim":187.0, - "partner":"8prq" + "partner":"8prh" }, { "sim":187.0, - "partner":"8prt" + "partner":"8pri" }, { "sim":187.0, - "partner":"8prd" + "partner":"8prm" }, { "sim":187.0, - "partner":"8prg" + "partner":"8prp" }, { "sim":187.0, - "partner":"8prh" + "partner":"8prq" }, { "sim":187.0, - "partner":"8pri" + "partner":"8prt" }, { "sim":187.0, - "partner":"8prm" + "partner":"8prd" }, { "sim":187.0, @@ -770353,11 +773416,11 @@ ], "seq_max_sim_designed":{ "sim":187.0, - "partner":"8pre" + "partner":"8prf" }, "seq_max_sim_natural":{ "sim":187.0, - "partner":"8prp" + "partner":"8prg" }, "struct_max_sim_designed":{ "sim":0.9983000159, @@ -770439,97 +773502,97 @@ ], "subtitle":"X-ray crystal structure of a de novo designed antiparallel coiled-coil 6-helix bundle with 4 heptad repeats, antiparallel 6-helix bundle-alia", "tags":[ + "coiled coil", "de novo protein design", - "6-helix bundle", "de novo protein", - "coiled coil", - "peptide assembly" + "peptide assembly", + "6-helix bundle" ], "keywords":[ - "require", - "monomeric", - "channels", - "seeded", - "peptide", - "accelerating", - "including", - "pipelines", + "made", + "open", + "genes", + "defined", + "escherichia", + "minimizes", + "families", + "rapidly", + "short", + "protein", + "six", + "fully", + "novo", "throughout", - "parallel", + "match", + "motifs", + "pipelines", + "two", + "helices", + "adjacent", + "antiparallel", + "characterized", + "however", + "soluble", + "starting", + "define", + "residues", + "targets", + "connected", + "layer", + "bind", + "proteins", + "accelerating", + "process", + "accuracy", "outer", + "small", + "barrel", + "longer", + "computational", + "including", + "peptide", + "design", "sampling", - "sequences", - "expression", - "bind", - "synthetic", + "onto", + "express", "packed", - "escherichia", + "loops", + "maintained", + "oligomeric", + "namely", + "validated", + "connectors", + "coli", + "parallel", "building", - "however", - "starting", + "seeded", + "channels", + "states", + "sequence", + "peptides", + "describe", + "assemblies", + "advancing", + "central", "average", - "longer", - "connectors", - "proteins", "models", - "process", - "de", - "characterized", - "rapidly", + "sequences", + "require", "efficient", - "open", - "small", - "short", - "maintained", - "fully", - "made", - "match", - "onto", + "loop", "structures", + "de", + "70", + "synthetic", + "monomeric", "give", - "motifs", "molecules", - "layer", - "loops", - "connected", - "defined", - "families", - "assemblies", - "coli", - "70", - "namely", - "define", - "six", - "design", - "minimizes", - "express", - "soluble", - "states", "routes", - "describe", "high", - "sequence", - "genes", - "accuracy", - "designs", - "advancing", - "helices", - "barrels", - "novo", - "barrel", "sufficient", - "peptides", - "residues", - "adjacent", - "two", - "validated", - "antiparallel", - "central", - "protein", - "targets", - "computational", - "oligomeric", - "loop" + "expression", + "designs", + "barrels" ], "release_date":"2024-07-03", "publication":"\"Rationally seeded computational protein design of ɑ-helical barrels\", Nat.Chem.Biol., 20, 991-999", @@ -770594,14 +773657,14 @@ "sim":1.0, "partner":"4h8m" }, - { - "sim":1.0, - "partner":"3r3k" - }, { "sim":0.9805999994, "partner":"6q5q" }, + { + "sim":1.0, + "partner":"3r3k" + }, { "sim":1.0, "partner":"3r48" @@ -770689,7 +773752,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"8qab" + "partner":"8a3g" }, "struct_max_sim_natural":{ "sim":1.0, @@ -770767,97 +773830,97 @@ ], "subtitle":"X-ray crystal structure of a de novo designed antiparallel coiled-coil hexameric alpha-helical barrel with 4 heptad repeats, apcchex", "tags":[ + "coiled coil", "de novo protein design", "de novo protein", - "coiled coil", - "alpha-helical barrel", - "peptide assembly" + "peptide assembly", + "alpha-helical barrel" ], "keywords":[ - "require", - "monomeric", - "channels", - "seeded", - "peptide", - "accelerating", - "including", - "pipelines", + "made", + "open", + "genes", + "defined", + "escherichia", + "minimizes", + "families", + "rapidly", + "short", + "protein", + "six", + "fully", + "novo", "throughout", - "parallel", + "match", + "motifs", + "pipelines", + "two", + "helices", + "adjacent", + "antiparallel", + "characterized", + "however", + "soluble", + "starting", + "define", + "residues", + "targets", + "connected", + "layer", + "bind", + "proteins", + "accelerating", + "process", + "accuracy", "outer", + "small", + "barrel", + "longer", + "computational", + "including", + "peptide", + "design", "sampling", - "sequences", - "expression", - "bind", - "synthetic", + "onto", + "express", "packed", - "escherichia", + "loops", + "maintained", + "oligomeric", + "namely", + "validated", + "connectors", + "coli", + "parallel", "building", - "however", - "starting", + "seeded", + "channels", + "states", + "sequence", + "peptides", + "describe", + "assemblies", + "advancing", + "central", "average", - "longer", - "connectors", - "proteins", "models", - "process", - "de", - "characterized", - "rapidly", + "sequences", + "require", "efficient", - "open", - "small", - "short", - "maintained", - "fully", - "made", - "match", - "onto", + "loop", "structures", + "de", + "70", + "synthetic", + "monomeric", "give", - "motifs", "molecules", - "layer", - "loops", - "connected", - "defined", - "families", - "assemblies", - "coli", - "70", - "namely", - "define", - "six", - "design", - "minimizes", - "express", - "soluble", - "states", "routes", - "describe", "high", - "sequence", - "genes", - "accuracy", - "designs", - "advancing", - "helices", - "barrels", - "novo", - "barrel", "sufficient", - "peptides", - "residues", - "adjacent", - "two", - "validated", - "antiparallel", - "central", - "protein", - "targets", - "computational", - "oligomeric", - "loop" + "expression", + "designs", + "barrels" ], "release_date":"2024-07-03", "publication":"\"Rationally seeded computational protein design of ɑ-helical barrels\", Nat.Chem.Biol., 20, 991-999", @@ -770986,6 +774049,10 @@ "sim":1.0, "partner":"4h8o" }, + { + "sim":0.9575999975, + "partner":"5vte" + }, { "sim":1.0, "partner":"4h8g" @@ -770993,10 +774060,6 @@ { "sim":0.9575999975, "partner":"5eoj" - }, - { - "sim":0.9575999975, - "partner":"5vte" } ], "struct_thr_sim_natural":[ @@ -771091,97 +774154,97 @@ ], "subtitle":"X-ray crystal structure of a de novo designed antiparallel coiled-coil 8-helix bundle with 4 heptad repeats, antiparallel 8-helix bundle-glia", "tags":[ + "coiled coil", "de novo protein design", - "8-helix bundle", "de novo protein", - "coiled coil", + "8-helix bundle", "peptide assembly" ], "keywords":[ - "require", - "monomeric", - "channels", - "seeded", - "peptide", - "accelerating", - "including", - "pipelines", + "made", + "open", + "genes", + "defined", + "escherichia", + "minimizes", + "families", + "rapidly", + "short", + "protein", + "six", + "fully", + "novo", "throughout", - "parallel", + "match", + "motifs", + "pipelines", + "two", + "helices", + "adjacent", + "antiparallel", + "characterized", + "however", + "soluble", + "starting", + "define", + "residues", + "targets", + "connected", + "layer", + "bind", + "proteins", + "accelerating", + "process", + "accuracy", "outer", + "small", + "barrel", + "longer", + "computational", + "including", + "peptide", + "design", "sampling", - "sequences", - "expression", - "bind", - "synthetic", + "onto", + "express", "packed", - "escherichia", + "loops", + "maintained", + "oligomeric", + "namely", + "validated", + "connectors", + "coli", + "parallel", "building", - "however", - "starting", + "seeded", + "channels", + "states", + "sequence", + "peptides", + "describe", + "assemblies", + "advancing", + "central", "average", - "longer", - "connectors", - "proteins", "models", - "process", - "de", - "characterized", - "rapidly", + "sequences", + "require", "efficient", - "open", - "small", - "short", - "maintained", - "fully", - "made", - "match", - "onto", + "loop", "structures", + "de", + "70", + "synthetic", + "monomeric", "give", - "motifs", "molecules", - "layer", - "loops", - "connected", - "defined", - "families", - "assemblies", - "coli", - "70", - "namely", - "define", - "six", - "design", - "minimizes", - "express", - "soluble", - "states", "routes", - "describe", "high", - "sequence", - "genes", - "accuracy", - "designs", - "advancing", - "helices", - "barrels", - "novo", - "barrel", "sufficient", - "peptides", - "residues", - "adjacent", - "two", - "validated", - "antiparallel", - "central", - "protein", - "targets", - "computational", - "oligomeric", - "loop" + "expression", + "designs", + "barrels" ], "release_date":"2024-07-03", "publication":"\"Rationally seeded computational protein design of ɑ-helical barrels\", Nat.Chem.Biol., 20, 991-999", @@ -771236,15 +774299,7 @@ }, { "sim":1.0, - "partner":"6q5q" - }, - { - "sim":0.9965000153, - "partner":"3r47" - }, - { - "sim":1.0, - "partner":"3r48" + "partner":"3r3k" }, { "sim":1.0, @@ -771252,36 +774307,28 @@ }, { "sim":1.0, - "partner":"3r3k" + "partner":"6q5q" }, { "sim":1.0, "partner":"3r46" }, - { - "sim":1.0, - "partner":"4h8m" - }, { "sim":1.0, "partner":"6q5s" }, { - "sim":0.9761999846, - "partner":"6q5o" + "sim":1.0, + "partner":"3r48" }, { - "sim":0.9761999846, - "partner":"8qae" + "sim":1.0, + "partner":"4h8m" }, { "sim":1.0, "partner":"5eon" }, - { - "sim":0.9955999851, - "partner":"4h8o" - }, { "sim":0.9983999729, "partner":"6q5p" @@ -771290,53 +774337,53 @@ "sim":1.0, "partner":"6q5r" }, - { - "sim":0.996900022, - "partner":"4h7r" - }, { "sim":1.0, "partner":"5vte" }, { - "sim":0.9983999729, - "partner":"3r4a" + "sim":0.9761999846, + "partner":"6q5o" }, { "sim":0.9973999858, "partner":"5eoj" }, { - "sim":0.9908999801, - "partner":"4h8f" - }, - { - "sim":0.9782000184, - "partner":"6yb0" + "sim":0.9955999851, + "partner":"4h8o" }, { - "sim":0.9714999795, - "partner":"4dzk" + "sim":0.996900022, + "partner":"4h7r" }, { "sim":1.0, "partner":"8qad" }, { - "sim":0.9743999839, - "partner":"6yaz" + "sim":0.9908999801, + "partner":"4h8f" }, { - "sim":0.951399982, - "partner":"6q5i" + "sim":0.9761999846, + "partner":"8qae" }, { - "sim":0.9559999704, - "partner":"6q5h" + "sim":0.9983999729, + "partner":"3r4a" }, { - "sim":0.9844999909, - "partner":"3r4h" + "sim":0.9782000184, + "partner":"6yb0" + }, + { + "sim":0.9965000153, + "partner":"3r47" + }, + { + "sim":0.9743999839, + "partner":"6yaz" }, { "sim":0.9524999857, @@ -771382,6 +774429,14 @@ "sim":0.9524999857, "partner":"7nfo" }, + { + "sim":0.951399982, + "partner":"6q5i" + }, + { + "sim":0.9559999704, + "partner":"6q5h" + }, { "sim":0.9524999857, "partner":"5ez8" @@ -771437,6 +774492,14 @@ { "sim":0.9524999857, "partner":"6g6f" + }, + { + "sim":0.9844999909, + "partner":"3r4h" + }, + { + "sim":0.9714999795, + "partner":"4dzk" } ], "struct_thr_sim_natural":[ @@ -771446,11 +774509,11 @@ }, { "sim":0.9983999729, - "partner":"4kvv" + "partner":"4kvu" }, { "sim":0.9983999729, - "partner":"4kvu" + "partner":"4kvv" } ], "seq_max_sim_designed":[ @@ -771461,7 +774524,7 @@ ], "struct_max_sim_designed":{ "sim":1.0, - "partner":"5eon" + "partner":"3r3k" }, "struct_max_sim_natural":{ "sim":0.9983999729, @@ -771545,90 +774608,90 @@ "alpha-helical barrel" ], "keywords":[ - "require", - "monomeric", - "channels", - "seeded", - "peptide", - "accelerating", - "including", - "pipelines", + "made", + "open", + "genes", + "defined", + "escherichia", + "minimizes", + "families", + "rapidly", + "short", + "protein", + "six", + "fully", + "novo", "throughout", - "parallel", + "match", + "motifs", + "pipelines", + "two", + "helices", + "adjacent", + "antiparallel", + "characterized", + "however", + "soluble", + "starting", + "define", + "residues", + "targets", + "connected", + "layer", + "bind", + "proteins", + "accelerating", + "process", + "accuracy", "outer", + "small", + "barrel", + "longer", + "computational", + "including", + "peptide", + "design", "sampling", - "sequences", - "expression", - "bind", - "synthetic", + "onto", + "express", "packed", - "escherichia", + "loops", + "maintained", + "oligomeric", + "namely", + "validated", + "connectors", + "coli", + "parallel", "building", - "however", - "starting", + "seeded", + "channels", + "states", + "sequence", + "peptides", + "describe", + "assemblies", + "advancing", + "central", "average", - "longer", - "connectors", - "proteins", "models", - "process", - "de", - "characterized", - "rapidly", + "sequences", + "require", "efficient", - "open", - "small", - "short", - "maintained", - "fully", - "made", - "match", - "onto", + "loop", "structures", + "de", + "70", + "synthetic", + "monomeric", "give", - "motifs", "molecules", - "layer", - "loops", - "connected", - "defined", - "families", - "assemblies", - "coli", - "70", - "namely", - "define", - "six", - "design", - "minimizes", - "express", - "soluble", - "states", "routes", - "describe", "high", - "sequence", - "genes", - "accuracy", - "designs", - "advancing", - "helices", - "barrels", - "novo", - "barrel", "sufficient", - "peptides", - "residues", - "adjacent", - "two", - "validated", - "antiparallel", - "central", - "protein", - "targets", - "computational", - "oligomeric", - "loop" + "expression", + "designs", + "barrels" ], "release_date":"2024-07-03", "publication":"\"Rationally seeded computational protein design of ɑ-helical barrels\", Nat.Chem.Biol., 20, 991-999", @@ -771673,27 +774736,27 @@ }, { "sim":60.0, - "partner":"8v2w" + "partner":"8v09" }, { "sim":60.0, - "partner":"8v09" + "partner":"8v2w" }, { "sim":59.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":59.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":59.0, - "partner":"8w08" + "partner":"8w06" }, { "sim":59.0, - "partner":"8w05" + "partner":"8v0a" }, { "sim":58.0, @@ -771721,11 +774784,11 @@ }, { "sim":51.0, - "partner":"8jpa" + "partner":"8hdv" }, { "sim":51.0, - "partner":"8hdv" + "partner":"8jpa" }, { "sim":51.0, @@ -771737,11 +774800,11 @@ }, { "sim":50.0, - "partner":"8j1x" + "partner":"8j98" }, { "sim":50.0, - "partner":"8j98" + "partner":"8j1x" }, { "sim":50.0, @@ -771793,10 +774856,6 @@ "sim":60.0, "partner":"2ihy" }, - { - "sim":59.0, - "partner":"5hso" - }, { "sim":59.0, "partner":"5x7z" @@ -771811,27 +774870,31 @@ }, { "sim":59.0, - "partner":"4evc" + "partner":"5hso" }, { "sim":59.0, - "partner":"4evd" + "partner":"3ta8" }, { "sim":59.0, - "partner":"4eve" + "partner":"3t9j" }, { "sim":59.0, - "partner":"3ta8" + "partner":"4evb" }, { "sim":59.0, - "partner":"3t9j" + "partner":"4evc" }, { "sim":59.0, - "partner":"4evb" + "partner":"4evd" + }, + { + "sim":59.0, + "partner":"4eve" }, { "sim":59.0, @@ -771891,24 +774954,12 @@ }, { "sim":57.0, - "partner":"5coq" - }, - { - "sim":57.0, - "partner":"5cpb" - }, - { - "sim":57.0, - "partner":"5mtr" + "partner":"4oxk" }, { "sim":57.0, "partner":"5ugt" }, - { - "sim":57.0, - "partner":"4oxk" - }, { "sim":57.0, "partner":"5ugu" @@ -771919,15 +774970,15 @@ }, { "sim":57.0, - "partner":"4oxn" + "partner":"6yuu" }, { "sim":57.0, - "partner":"4oyr" + "partner":"4oxn" }, { "sim":57.0, - "partner":"6yuu" + "partner":"4oyr" }, { "sim":57.0, @@ -771953,10 +775004,22 @@ "sim":57.0, "partner":"5cp8" }, + { + "sim":57.0, + "partner":"5mtr" + }, { "sim":57.0, "partner":"5ugs" }, + { + "sim":57.0, + "partner":"5cpb" + }, + { + "sim":57.0, + "partner":"5coq" + }, { "sim":57.0, "partner":"1zun" @@ -771967,123 +775030,123 @@ }, { "sim":57.0, - "partner":"1xoq" + "partner":"1y2b" }, { "sim":57.0, - "partner":"6ind" + "partner":"6imt" }, { "sim":57.0, - "partner":"8w4r" + "partner":"1y2c" }, { "sim":57.0, - "partner":"1xor" + "partner":"8k4c" }, { "sim":57.0, - "partner":"3iak" + "partner":"6ink" }, { "sim":57.0, - "partner":"6imr" + "partner":"1y2d" }, { "sim":57.0, - "partner":"7cbj" + "partner":"1y2e" }, { "sim":57.0, - "partner":"1y2b" + "partner":"6inm" }, { "sim":57.0, - "partner":"6im6" + "partner":"6imb" }, { "sim":57.0, - "partner":"6imt" + "partner":"7cbq" }, { "sim":57.0, - "partner":"1y2c" + "partner":"7ysx" }, { "sim":57.0, - "partner":"1y2d" + "partner":"6imd" }, { "sim":57.0, - "partner":"6ink" + "partner":"8w4q" }, { "sim":57.0, - "partner":"1y2e" + "partner":"8w4r" }, { "sim":57.0, - "partner":"6inm" + "partner":"1y2k" }, { "sim":57.0, - "partner":"6imb" + "partner":"6imi" }, { "sim":57.0, - "partner":"8k4h" + "partner":"6imo" }, { "sim":57.0, - "partner":"7ysx" + "partner":"6lrm" }, { "sim":57.0, - "partner":"7cbq" + "partner":"1xom" }, { "sim":57.0, - "partner":"8k4c" + "partner":"1xon" }, { "sim":57.0, - "partner":"6imd" + "partner":"3k4s" }, { "sim":57.0, - "partner":"1y2k" + "partner":"7yqf" }, { "sim":57.0, - "partner":"1xom" + "partner":"6ind" }, { "sim":57.0, - "partner":"6imi" + "partner":"1xoq" }, { "sim":57.0, - "partner":"6imo" + "partner":"7cbj" }, { "sim":57.0, - "partner":"6lrm" + "partner":"6imr" }, { "sim":57.0, - "partner":"1xon" + "partner":"1xor" }, { "sim":57.0, - "partner":"3k4s" + "partner":"6im6" }, { "sim":57.0, - "partner":"7yqf" + "partner":"8k4h" }, { "sim":57.0, - "partner":"8w4q" + "partner":"3iak" }, { "sim":57.0, @@ -772157,10 +775220,6 @@ "sim":56.0, "partner":"7l9a" }, - { - "sim":56.0, - "partner":"3rg6" - }, { "sim":56.0, "partner":"2wvw" @@ -772175,7 +775234,7 @@ }, { "sim":56.0, - "partner":"6o98" + "partner":"3rg6" }, { "sim":56.0, @@ -772191,15 +775250,11 @@ }, { "sim":56.0, - "partner":"3cu0" - }, - { - "sim":56.0, - "partner":"7kqj" + "partner":"6o98" }, { "sim":56.0, - "partner":"6vqf" + "partner":"3cu0" }, { "sim":56.0, @@ -772245,6 +775300,14 @@ "sim":56.0, "partner":"7luk" }, + { + "sim":56.0, + "partner":"6vqf" + }, + { + "sim":56.0, + "partner":"7kqj" + }, { "sim":56.0, "partner":"1mx3" @@ -772379,15 +775442,15 @@ }, { "sim":55.0, - "partner":"4bmx" + "partner":"4bmz" }, { "sim":55.0, - "partner":"4bmy" + "partner":"4bmx" }, { "sim":55.0, - "partner":"4bmz" + "partner":"4bmy" }, { "sim":55.0, @@ -772431,15 +775494,15 @@ }, { "sim":55.0, - "partner":"1zw3" + "partner":"1zvz" }, { "sim":55.0, - "partner":"1zvz" + "partner":"1zw2" }, { "sim":55.0, - "partner":"1zw2" + "partner":"1zw3" }, { "sim":55.0, @@ -772457,10 +775520,6 @@ "sim":55.0, "partner":"3doj" }, - { - "sim":55.0, - "partner":"3aio" - }, { "sim":55.0, "partner":"3aik" @@ -772477,6 +775536,10 @@ "sim":55.0, "partner":"3ain" }, + { + "sim":55.0, + "partner":"3aio" + }, { "sim":55.0, "partner":"5zl1" @@ -772507,15 +775570,15 @@ }, { "sim":55.0, - "partner":"5v1s" + "partner":"5v1t" }, { "sim":55.0, - "partner":"5v1t" + "partner":"5v1q" }, { "sim":55.0, - "partner":"5v1q" + "partner":"5v1s" }, { "sim":55.0, @@ -772553,14 +775616,6 @@ "sim":54.0, "partner":"2bze" }, - { - "sim":54.0, - "partner":"5scp" - }, - { - "sim":54.0, - "partner":"5scq" - }, { "sim":54.0, "partner":"5scr" @@ -772663,7 +775718,11 @@ }, { "sim":54.0, - "partner":"7t9o" + "partner":"5scp" + }, + { + "sim":54.0, + "partner":"5scq" }, { "sim":54.0, @@ -772683,31 +775742,11 @@ }, { "sim":54.0, - "partner":"4cec" - }, - { - "sim":54.0, - "partner":"4cgf" - }, - { - "sim":54.0, - "partner":"4chp" - }, - { - "sim":54.0, - "partner":"4cjt" - }, - { - "sim":54.0, - "partner":"3avi" - }, - { - "sim":54.0, - "partner":"4chq" + "partner":"7t9o" }, { "sim":54.0, - "partner":"4ovl" + "partner":"3av9" }, { "sim":54.0, @@ -772725,10 +775764,6 @@ "sim":54.0, "partner":"4cju" }, - { - "sim":54.0, - "partner":"3av9" - }, { "sim":54.0, "partner":"4cee" @@ -772993,6 +776028,34 @@ "sim":54.0, "partner":"4cjs" }, + { + "sim":54.0, + "partner":"4chp" + }, + { + "sim":54.0, + "partner":"4cec" + }, + { + "sim":54.0, + "partner":"4cgf" + }, + { + "sim":54.0, + "partner":"4cjt" + }, + { + "sim":54.0, + "partner":"3avi" + }, + { + "sim":54.0, + "partner":"4chq" + }, + { + "sim":54.0, + "partner":"4ovl" + }, { "sim":54.0, "partner":"5w10" @@ -773055,11 +776118,11 @@ }, { "sim":54.0, - "partner":"6fcn" + "partner":"6fcm" }, { "sim":54.0, - "partner":"6fcm" + "partner":"6fcn" }, { "sim":54.0, @@ -773083,11 +776146,11 @@ }, { "sim":54.0, - "partner":"5lsg" + "partner":"6t9c" }, { "sim":54.0, - "partner":"6t9c" + "partner":"5lsg" }, { "sim":54.0, @@ -773103,19 +776166,19 @@ }, { "sim":54.0, - "partner":"3nha" + "partner":"3nh6" }, { "sim":54.0, - "partner":"3nhb" + "partner":"3nh9" }, { "sim":54.0, - "partner":"3nh6" + "partner":"3nha" }, { "sim":54.0, - "partner":"3nh9" + "partner":"3nhb" }, { "sim":54.0, @@ -773131,27 +776194,27 @@ }, { "sim":54.0, - "partner":"4mfj" + "partner":"4mfl" }, { "sim":54.0, - "partner":"4mfk" + "partner":"4mfp" }, { "sim":54.0, - "partner":"4mfl" + "partner":"4mfq" }, { "sim":54.0, - "partner":"6iix" + "partner":"4mfj" }, { "sim":54.0, - "partner":"4mfp" + "partner":"6iix" }, { "sim":54.0, - "partner":"4mfq" + "partner":"4mfk" }, { "sim":54.0, @@ -773191,15 +776254,15 @@ }, { "sim":54.0, - "partner":"6s0g" + "partner":"7bn6" }, { "sim":54.0, - "partner":"7bn6" + "partner":"6s23" }, { "sim":54.0, - "partner":"6s23" + "partner":"6s0g" }, { "sim":54.0, @@ -773239,15 +776302,15 @@ }, { "sim":54.0, - "partner":"5kdn" + "partner":"5kds" }, { "sim":54.0, - "partner":"5kds" + "partner":"5kdu" }, { "sim":54.0, - "partner":"5kdu" + "partner":"5kdn" }, { "sim":54.0, @@ -773407,27 +776470,27 @@ }, { "sim":53.0, - "partner":"6tlm" + "partner":"6tlt" }, { "sim":53.0, - "partner":"6tlq" + "partner":"6t4g" }, { "sim":53.0, - "partner":"6tlt" + "partner":"6t4i" }, { "sim":53.0, - "partner":"6t4g" + "partner":"6t4j" }, { "sim":53.0, - "partner":"6t4i" + "partner":"6t4k" }, { "sim":53.0, - "partner":"6t4j" + "partner":"6t4x" }, { "sim":53.0, @@ -773435,19 +776498,19 @@ }, { "sim":53.0, - "partner":"6t4k" + "partner":"6t4y" }, { "sim":53.0, - "partner":"6t4x" + "partner":"6t50" }, { "sim":53.0, - "partner":"6t4y" + "partner":"6tlm" }, { "sim":53.0, - "partner":"6t50" + "partner":"6tlq" }, { "sim":53.0, @@ -773473,10 +776536,6 @@ "sim":53.0, "partner":"3uic" }, - { - "sim":53.0, - "partner":"4j3f" - }, { "sim":53.0, "partner":"4j4t" @@ -773489,6 +776548,10 @@ "sim":53.0, "partner":"4j1n" }, + { + "sim":53.0, + "partner":"4j3f" + }, { "sim":53.0, "partner":"3g9g" @@ -773581,14 +776644,6 @@ "sim":53.0, "partner":"4s2b" }, - { - "sim":53.0, - "partner":"5gg5" - }, - { - "sim":53.0, - "partner":"5xd1" - }, { "sim":53.0, "partner":"5gg6" @@ -773603,27 +776658,27 @@ }, { "sim":53.0, - "partner":"5gg7" + "partner":"6m6y" }, { "sim":53.0, - "partner":"5xd4" + "partner":"5gg7" }, { "sim":53.0, - "partner":"5xd5" + "partner":"5xd4" }, { "sim":53.0, - "partner":"6m6y" + "partner":"6m65" }, { "sim":53.0, - "partner":"5gg8" + "partner":"5xd5" }, { "sim":53.0, - "partner":"6m65" + "partner":"5gg8" }, { "sim":53.0, @@ -773655,12 +776710,20 @@ }, { "sim":53.0, - "partner":"6vwr" + "partner":"5gg5" + }, + { + "sim":53.0, + "partner":"5xd1" }, { "sim":53.0, "partner":"6vwq" }, + { + "sim":53.0, + "partner":"6vwr" + }, { "sim":53.0, "partner":"8b3s" @@ -773679,23 +776742,23 @@ }, { "sim":53.0, - "partner":"1x19" + "partner":"1x1b" }, { "sim":53.0, - "partner":"1x1a" + "partner":"1x1c" }, { "sim":53.0, - "partner":"1x1b" + "partner":"1x1d" }, { "sim":53.0, - "partner":"1x1c" + "partner":"1x19" }, { "sim":53.0, - "partner":"1x1d" + "partner":"1x1a" }, { "sim":53.0, @@ -773781,10 +776844,6 @@ "sim":53.0, "partner":"3khz" }, - { - "sim":53.0, - "partner":"4dqw" - }, { "sim":53.0, "partner":"6gjv" @@ -773795,11 +776854,11 @@ }, { "sim":53.0, - "partner":"2inr" + "partner":"4dqw" }, { "sim":53.0, - "partner":"8iat" + "partner":"2inr" }, { "sim":53.0, @@ -773823,15 +776882,15 @@ }, { "sim":53.0, - "partner":"6gnf" + "partner":"8iat" }, { "sim":53.0, - "partner":"4lu6" + "partner":"6gnf" }, { "sim":53.0, - "partner":"5tsh" + "partner":"4lu6" }, { "sim":53.0, @@ -773841,6 +776900,10 @@ "sim":53.0, "partner":"5tsg" }, + { + "sim":53.0, + "partner":"5tsh" + }, { "sim":53.0, "partner":"5apn" @@ -773857,10 +776920,6 @@ "sim":53.0, "partner":"6k0w" }, - { - "sim":53.0, - "partner":"7rpw" - }, { "sim":53.0, "partner":"2hiv" @@ -773877,6 +776936,10 @@ "sim":53.0, "partner":"7rpo" }, + { + "sim":53.0, + "partner":"7rpw" + }, { "sim":52.0, "partner":"1m94" @@ -773887,15 +776950,15 @@ }, { "sim":52.0, - "partner":"2ese" + "partner":"2lmr" }, { "sim":52.0, - "partner":"2lmr" + "partner":"2es6" }, { "sim":52.0, - "partner":"2es6" + "partner":"2ese" }, { "sim":52.0, @@ -773943,15 +777006,15 @@ }, { "sim":52.0, - "partner":"6tq2" + "partner":"4azn" }, { "sim":52.0, - "partner":"4azn" + "partner":"6tq1" }, { "sim":52.0, - "partner":"6tq1" + "partner":"6tq2" }, { "sim":52.0, @@ -774027,23 +777090,23 @@ }, { "sim":52.0, - "partner":"4njh" + "partner":"4njj" }, { "sim":52.0, - "partner":"4nji" + "partner":"4njk" }, { "sim":52.0, - "partner":"4njj" + "partner":"4njg" }, { "sim":52.0, - "partner":"4njk" + "partner":"4njh" }, { "sim":52.0, - "partner":"4njg" + "partner":"4nji" }, { "sim":52.0, @@ -774199,47 +777262,47 @@ }, { "sim":52.0, - "partner":"7wxl" + "partner":"7wxp" }, { "sim":52.0, - "partner":"7wxm" + "partner":"7wxq" }, { "sim":52.0, - "partner":"7wxn" + "partner":"7wxr" }, { "sim":52.0, - "partner":"7wxo" + "partner":"7xte" }, { "sim":52.0, - "partner":"7wxp" + "partner":"7xtf" }, { "sim":52.0, - "partner":"7wxq" + "partner":"7wxj" }, { "sim":52.0, - "partner":"7wxr" + "partner":"7wxk" }, { "sim":52.0, - "partner":"7xte" + "partner":"7wxl" }, { "sim":52.0, - "partner":"7xtf" + "partner":"7wxm" }, { "sim":52.0, - "partner":"7wxj" + "partner":"7wxn" }, { "sim":52.0, - "partner":"7wxk" + "partner":"7wxo" }, { "sim":52.0, @@ -774249,10 +777312,6 @@ "sim":52.0, "partner":"5uqx" }, - { - "sim":52.0, - "partner":"3c1y" - }, { "sim":52.0, "partner":"3c1z" @@ -774277,6 +777336,10 @@ "sim":52.0, "partner":"4yxm" }, + { + "sim":52.0, + "partner":"3c1y" + }, { "sim":52.0, "partner":"4ot7" @@ -774367,15 +777430,15 @@ }, { "sim":52.0, - "partner":"8il0" + "partner":"2rim" }, { "sim":52.0, - "partner":"2rim" + "partner":"8ila" }, { "sim":52.0, - "partner":"8ila" + "partner":"8il0" }, { "sim":52.0, @@ -774411,15 +777474,15 @@ }, { "sim":52.0, - "partner":"4l2h" + "partner":"4epp" }, { "sim":52.0, - "partner":"4epp" + "partner":"4epq" }, { "sim":52.0, - "partner":"4epq" + "partner":"4l2h" }, { "sim":52.0, @@ -774441,10 +777504,6 @@ "sim":52.0, "partner":"6l4o" }, - { - "sim":52.0, - "partner":"6p00" - }, { "sim":52.0, "partner":"7ju0" @@ -774473,6 +777532,10 @@ "sim":52.0, "partner":"2e4g" }, + { + "sim":52.0, + "partner":"6p00" + }, { "sim":52.0, "partner":"8jor" @@ -774643,15 +777706,15 @@ }, { "sim":51.0, - "partner":"3qna" + "partner":"3qn0" }, { "sim":51.0, - "partner":"3qn0" + "partner":"3qn9" }, { "sim":51.0, - "partner":"3qn9" + "partner":"3qna" }, { "sim":51.0, @@ -774679,47 +777742,43 @@ }, { "sim":51.0, - "partner":"5y0f" - }, - { - "sim":51.0, - "partner":"5y0g" + "partner":"4nns" }, { "sim":51.0, - "partner":"4nns" + "partner":"4nnt" }, { "sim":51.0, - "partner":"4nnt" + "partner":"6ljs" }, { "sim":51.0, - "partner":"5y12" + "partner":"6ljt" }, { "sim":51.0, - "partner":"6ljs" + "partner":"6lyw" }, { "sim":51.0, - "partner":"5d45" + "partner":"8wdx" }, { "sim":51.0, - "partner":"5y13" + "partner":"5y12" }, { "sim":51.0, - "partner":"6ljt" + "partner":"6lju" }, { "sim":51.0, - "partner":"6lyw" + "partner":"5d45" }, { "sim":51.0, - "partner":"6lju" + "partner":"5y13" }, { "sim":51.0, @@ -774739,7 +777798,7 @@ }, { "sim":51.0, - "partner":"8wdx" + "partner":"8we3" }, { "sim":51.0, @@ -774751,19 +777810,19 @@ }, { "sim":51.0, - "partner":"8we3" + "partner":"5y0x" }, { "sim":51.0, - "partner":"5y0x" + "partner":"5y0f" }, { "sim":51.0, - "partner":"6lyx" + "partner":"5y0g" }, { "sim":51.0, - "partner":"3sw1" + "partner":"6lyx" }, { "sim":51.0, @@ -774787,11 +777846,11 @@ }, { "sim":51.0, - "partner":"7r4s" + "partner":"6gg9" }, { "sim":51.0, - "partner":"6gg9" + "partner":"7r4s" }, { "sim":51.0, @@ -774799,15 +777858,15 @@ }, { "sim":51.0, - "partner":"6bws" + "partner":"3sw1" }, { "sim":51.0, - "partner":"6c0z" + "partner":"6bws" }, { "sim":51.0, - "partner":"2o4e" + "partner":"6c0z" }, { "sim":51.0, @@ -774815,11 +777874,11 @@ }, { "sim":51.0, - "partner":"5luv" + "partner":"2o4e" }, { "sim":51.0, - "partner":"1vb6" + "partner":"5luv" }, { "sim":51.0, @@ -774833,6 +777892,10 @@ "sim":51.0, "partner":"1v9z" }, + { + "sim":51.0, + "partner":"1vb6" + }, { "sim":51.0, "partner":"5x9k" @@ -774923,7 +777986,7 @@ }, { "sim":51.0, - "partner":"8xon" + "partner":"8xoo" }, { "sim":51.0, @@ -774931,19 +777994,15 @@ }, { "sim":51.0, - "partner":"8xoo" - }, - { - "sim":51.0, - "partner":"6pj9" + "partner":"8xon" }, { "sim":51.0, - "partner":"6pja" + "partner":"6pjp" }, { "sim":51.0, - "partner":"6pjp" + "partner":"6pjq" }, { "sim":51.0, @@ -774951,11 +778010,11 @@ }, { "sim":51.0, - "partner":"6pjq" + "partner":"6pjr" }, { "sim":51.0, - "partner":"6pjr" + "partner":"6pju" }, { "sim":51.0, @@ -774965,10 +778024,6 @@ "sim":51.0, "partner":"5f5d" }, - { - "sim":51.0, - "partner":"6pju" - }, { "sim":51.0, "partner":"4njp" @@ -774991,15 +778046,19 @@ }, { "sim":51.0, - "partner":"5f5j" + "partner":"6pj5" }, { "sim":51.0, - "partner":"6pj5" + "partner":"6pj7" }, { "sim":51.0, - "partner":"6pj7" + "partner":"5f5j" + }, + { + "sim":51.0, + "partner":"6pj8" }, { "sim":51.0, @@ -775007,7 +778066,11 @@ }, { "sim":51.0, - "partner":"6pj8" + "partner":"6pj9" + }, + { + "sim":51.0, + "partner":"6pja" }, { "sim":51.0, @@ -775067,15 +778130,15 @@ }, { "sim":51.0, - "partner":"7zkt" + "partner":"3bhd" }, { "sim":51.0, - "partner":"3bhd" + "partner":"7zhc" }, { "sim":51.0, - "partner":"7zhc" + "partner":"7zkt" }, { "sim":51.0, @@ -775095,11 +778158,11 @@ }, { "sim":51.0, - "partner":"4d7l" + "partner":"8vai" }, { "sim":51.0, - "partner":"8vai" + "partner":"4d7l" }, { "sim":51.0, @@ -775177,10 +778240,6 @@ "sim":51.0, "partner":"2olk" }, - { - "sim":51.0, - "partner":"4yvk" - }, { "sim":51.0, "partner":"8apt" @@ -775225,6 +778284,10 @@ "sim":51.0, "partner":"4yvj" }, + { + "sim":51.0, + "partner":"4yvk" + }, { "sim":51.0, "partner":"4lbd" @@ -775249,14 +778312,6 @@ "sim":51.0, "partner":"4m7t" }, - { - "sim":51.0, - "partner":"5ds3" - }, - { - "sim":51.0, - "partner":"6bhv" - }, { "sim":51.0, "partner":"6ntu" @@ -775269,10 +778324,6 @@ "sim":51.0, "partner":"2f9t" }, - { - "sim":51.0, - "partner":"2f9w" - }, { "sim":51.0, "partner":"8fz1" @@ -775283,12 +778334,16 @@ }, { "sim":51.0, - "partner":"6nrf" + "partner":"2f9w" }, { "sim":51.0, "partner":"8fyz" }, + { + "sim":51.0, + "partner":"6nrf" + }, { "sim":51.0, "partner":"6nrg" @@ -775305,6 +778360,14 @@ "sim":51.0, "partner":"6nrj" }, + { + "sim":51.0, + "partner":"6bhv" + }, + { + "sim":51.0, + "partner":"5ds3" + }, { "sim":51.0, "partner":"7wzf" @@ -775399,31 +778462,31 @@ }, { "sim":51.0, - "partner":"5lto" + "partner":"8rwq" }, { "sim":51.0, - "partner":"7a61" + "partner":"6mnp" }, { "sim":51.0, - "partner":"5uj3" + "partner":"8rwr" }, { "sim":51.0, - "partner":"5uj4" + "partner":"5uj3" }, { "sim":51.0, - "partner":"6mnp" + "partner":"6d15" }, { "sim":51.0, - "partner":"6d15" + "partner":"8rws" }, { "sim":51.0, - "partner":"5ul8" + "partner":"5uj4" }, { "sim":51.0, @@ -775435,16 +778498,20 @@ }, { "sim":51.0, - "partner":"5lt9" + "partner":"6d17" }, { "sim":51.0, - "partner":"6d17" + "partner":"5ul8" }, { "sim":51.0, "partner":"6d18" }, + { + "sim":51.0, + "partner":"5lt9" + }, { "sim":51.0, "partner":"6d19" @@ -775465,10 +778532,6 @@ "sim":51.0, "partner":"6z22" }, - { - "sim":51.0, - "partner":"2vvt" - }, { "sim":51.0, "partner":"6qwb" @@ -775485,6 +778548,10 @@ "sim":51.0, "partner":"6z24" }, + { + "sim":51.0, + "partner":"2vvt" + }, { "sim":51.0, "partner":"6qwd" @@ -775499,15 +778566,15 @@ }, { "sim":51.0, - "partner":"8rwq" + "partner":"6mey" }, { "sim":51.0, - "partner":"6mey" + "partner":"6v1j" }, { "sim":51.0, - "partner":"6v1j" + "partner":"8aki" }, { "sim":51.0, @@ -775515,7 +778582,7 @@ }, { "sim":51.0, - "partner":"8aki" + "partner":"8akj" }, { "sim":51.0, @@ -775527,7 +778594,7 @@ }, { "sim":51.0, - "partner":"8akj" + "partner":"8akk" }, { "sim":51.0, @@ -775535,15 +778602,27 @@ }, { "sim":51.0, - "partner":"8akk" + "partner":"8akl" }, { "sim":51.0, - "partner":"8akl" + "partner":"8akm" }, { "sim":51.0, - "partner":"8akm" + "partner":"5lto" + }, + { + "sim":51.0, + "partner":"7a61" + }, + { + "sim":51.0, + "partner":"8rwo" + }, + { + "sim":51.0, + "partner":"8rwp" }, { "sim":51.0, @@ -775593,6 +778672,10 @@ "sim":51.0, "partner":"7qv9" }, + { + "sim":51.0, + "partner":"7emz" + }, { "sim":51.0, "partner":"7enb" @@ -775603,7 +778686,7 @@ }, { "sim":51.0, - "partner":"7emz" + "partner":"3t9w" }, { "sim":51.0, @@ -775611,16 +778694,12 @@ }, { "sim":51.0, - "partner":"3t9w" + "partner":"6juz" }, { "sim":51.0, "partner":"4pne" }, - { - "sim":51.0, - "partner":"6juz" - }, { "sim":51.0, "partner":"6jv0" @@ -775643,11 +778722,11 @@ }, { "sim":51.0, - "partner":"5a7y" + "partner":"4mup" }, { "sim":51.0, - "partner":"4mup" + "partner":"5a7y" }, { "sim":51.0, @@ -775657,10 +778736,6 @@ "sim":51.0, "partner":"7e4m" }, - { - "sim":51.0, - "partner":"3ggo" - }, { "sim":51.0, "partner":"3ggp" @@ -775673,6 +778748,10 @@ "sim":51.0, "partner":"5ybl" }, + { + "sim":51.0, + "partner":"3ggo" + }, { "sim":51.0, "partner":"7c0q" @@ -775703,11 +778782,11 @@ }, { "sim":51.0, - "partner":"3auz" + "partner":"6q75" }, { "sim":51.0, - "partner":"6q75" + "partner":"3auz" }, { "sim":51.0, @@ -775715,23 +778794,23 @@ }, { "sim":51.0, - "partner":"6q4x" + "partner":"6q4z" }, { "sim":51.0, - "partner":"6q4y" + "partner":"5zci" }, { "sim":51.0, - "partner":"6q4z" + "partner":"5zcm" }, { "sim":51.0, - "partner":"5zci" + "partner":"6q4x" }, { "sim":51.0, - "partner":"5zcm" + "partner":"6q4y" }, { "sim":51.0, @@ -775753,10 +778832,6 @@ "sim":51.0, "partner":"4h3h" }, - { - "sim":51.0, - "partner":"5g6t" - }, { "sim":51.0, "partner":"5g5u" @@ -775785,6 +778860,10 @@ "sim":51.0, "partner":"5g5k" }, + { + "sim":51.0, + "partner":"5g6t" + }, { "sim":51.0, "partner":"4ilk" @@ -775833,14 +778912,6 @@ "sim":51.0, "partner":"8skn" }, - { - "sim":51.0, - "partner":"4q3r" - }, - { - "sim":51.0, - "partner":"4q42" - }, { "sim":51.0, "partner":"4q3s" @@ -775875,7 +778946,11 @@ }, { "sim":51.0, - "partner":"7azd" + "partner":"4q3r" + }, + { + "sim":51.0, + "partner":"4q42" }, { "sim":51.0, @@ -775891,12 +778966,16 @@ }, { "sim":51.0, - "partner":"5f3w" + "partner":"8k2y" }, { "sim":51.0, "partner":"7aze" }, + { + "sim":51.0, + "partner":"5f3w" + }, { "sim":51.0, "partner":"7az6" @@ -775919,16 +778998,12 @@ }, { "sim":51.0, - "partner":"8k2y" + "partner":"7azg" }, { "sim":51.0, "partner":"5x06" }, - { - "sim":51.0, - "partner":"7azg" - }, { "sim":51.0, "partner":"7azc" @@ -775939,7 +779014,7 @@ }, { "sim":51.0, - "partner":"6c8v" + "partner":"7azd" }, { "sim":51.0, @@ -775949,6 +779024,10 @@ "sim":51.0, "partner":"3vvm" }, + { + "sim":51.0, + "partner":"6c8v" + }, { "sim":51.0, "partner":"8uce" @@ -776105,10 +779184,6 @@ "sim":51.0, "partner":"4j1s" }, - { - "sim":51.0, - "partner":"4acg" - }, { "sim":51.0, "partner":"4ach" @@ -776127,12 +779202,16 @@ }, { "sim":51.0, - "partner":"6ak4" + "partner":"4acg" }, { "sim":51.0, "partner":"6aej" }, + { + "sim":51.0, + "partner":"6ak4" + }, { "sim":51.0, "partner":"6wiu" @@ -776161,10 +779240,6 @@ "sim":51.0, "partner":"8hcz" }, - { - "sim":51.0, - "partner":"6rk2" - }, { "sim":51.0, "partner":"6rjo" @@ -776179,11 +779254,11 @@ }, { "sim":51.0, - "partner":"6akw" + "partner":"6rk2" }, { "sim":51.0, - "partner":"4ie7" + "partner":"6akw" }, { "sim":51.0, @@ -776203,15 +779278,15 @@ }, { "sim":51.0, - "partner":"4idz" + "partner":"7e8z" }, { "sim":51.0, - "partner":"4ie0" + "partner":"4idz" }, { "sim":51.0, - "partner":"7e8z" + "partner":"4ie0" }, { "sim":51.0, @@ -776229,6 +779304,10 @@ "sim":51.0, "partner":"4qho" }, + { + "sim":51.0, + "partner":"4ie7" + }, { "sim":51.0, "partner":"7x4r" @@ -776263,79 +779342,79 @@ }, { "sim":51.0, - "partner":"8gf0" + "partner":"7lam" }, { "sim":51.0, - "partner":"8gfp" + "partner":"8gfb" }, { "sim":51.0, - "partner":"8gf1" + "partner":"8gfc" }, { "sim":51.0, - "partner":"8gfq" + "partner":"8gfd" }, { "sim":51.0, - "partner":"8gfs" + "partner":"8gfe" }, { "sim":51.0, - "partner":"7lam" + "partner":"7laq" }, { "sim":51.0, - "partner":"7laq" + "partner":"8gff" }, { "sim":51.0, - "partner":"8gfb" + "partner":"8gfg" }, { "sim":51.0, - "partner":"8gfc" + "partner":"8gfh" }, { "sim":51.0, - "partner":"8gfd" + "partner":"8gfi" }, { "sim":51.0, - "partner":"8gfe" + "partner":"8gfj" }, { "sim":51.0, - "partner":"8gff" + "partner":"8gfl" }, { "sim":51.0, - "partner":"8gfg" + "partner":"8gfm" }, { "sim":51.0, - "partner":"8gfh" + "partner":"8gez" }, { "sim":51.0, - "partner":"8gfi" + "partner":"8gf0" }, { "sim":51.0, - "partner":"8gfj" + "partner":"8gfp" }, { "sim":51.0, - "partner":"8gfl" + "partner":"8gf1" }, { "sim":51.0, - "partner":"8gfm" + "partner":"8gfq" }, { "sim":51.0, - "partner":"8gez" + "partner":"8gfs" }, { "sim":51.0, @@ -776353,10 +779432,6 @@ "sim":51.0, "partner":"7xkw" }, - { - "sim":51.0, - "partner":"5wm2" - }, { "sim":51.0, "partner":"5wm3" @@ -776379,31 +779454,31 @@ }, { "sim":51.0, - "partner":"3hx6" + "partner":"5wm2" }, { "sim":51.0, - "partner":"8hdf" + "partner":"3hx6" }, { "sim":51.0, - "partner":"8iqu" + "partner":"8hd4" }, { "sim":51.0, - "partner":"8hd4" + "partner":"8hdf" }, { "sim":51.0, - "partner":"8t3k" + "partner":"8iqu" }, { "sim":51.0, - "partner":"8szc" + "partner":"8t3k" }, { "sim":51.0, - "partner":"8t1p" + "partner":"8szc" }, { "sim":51.0, @@ -776419,11 +779494,11 @@ }, { "sim":51.0, - "partner":"8fmv" + "partner":"8t1p" }, { "sim":51.0, - "partner":"7tgl" + "partner":"8fmv" }, { "sim":51.0, @@ -776445,6 +779520,10 @@ "sim":51.0, "partner":"7tgk" }, + { + "sim":51.0, + "partner":"7tgl" + }, { "sim":51.0, "partner":"7zki" @@ -776477,10 +779556,6 @@ "sim":51.0, "partner":"7bn9" }, - { - "sim":51.0, - "partner":"2bpo" - }, { "sim":51.0, "partner":"2bf4" @@ -776491,15 +779566,7 @@ }, { "sim":51.0, - "partner":"2yii" - }, - { - "sim":51.0, - "partner":"4c5s" - }, - { - "sim":51.0, - "partner":"4v2r" + "partner":"2bpo" }, { "sim":51.0, @@ -776525,13 +779592,21 @@ "sim":51.0, "partner":"4c5r" }, + { + "sim":51.0, + "partner":"2yii" + }, { "sim":51.0, "partner":"4v2q" }, { "sim":51.0, - "partner":"7wlg" + "partner":"4c5s" + }, + { + "sim":51.0, + "partner":"4v2r" }, { "sim":51.0, @@ -776563,7 +779638,7 @@ }, { "sim":51.0, - "partner":"8wxf" + "partner":"7wlg" }, { "sim":51.0, @@ -776573,6 +779648,10 @@ "sim":51.0, "partner":"8wwp" }, + { + "sim":51.0, + "partner":"8wxf" + }, { "sim":51.0, "partner":"6vxc" @@ -776617,10 +779696,6 @@ "sim":51.0, "partner":"7ufu" }, - { - "sim":51.0, - "partner":"6yt0" - }, { "sim":51.0, "partner":"4zhj" @@ -776637,6 +779712,10 @@ "sim":51.0, "partner":"6ytj" }, + { + "sim":51.0, + "partner":"6yt0" + }, { "sim":50.0, "partner":"1umq" @@ -776687,11 +779766,11 @@ }, { "sim":50.0, - "partner":"3ssq" + "partner":"6izs" }, { "sim":50.0, - "partner":"6izs" + "partner":"3ssq" }, { "sim":50.0, @@ -776703,11 +779782,11 @@ }, { "sim":50.0, - "partner":"3va4" + "partner":"6t3o" }, { "sim":50.0, - "partner":"6t3o" + "partner":"3va4" }, { "sim":50.0, @@ -776719,11 +779798,11 @@ }, { "sim":50.0, - "partner":"5x3t" + "partner":"6cky" }, { "sim":50.0, - "partner":"6cky" + "partner":"5x3t" }, { "sim":50.0, @@ -776851,11 +779930,11 @@ }, { "sim":50.0, - "partner":"4o8t" + "partner":"4o8l" }, { "sim":50.0, - "partner":"4o8l" + "partner":"4o8t" }, { "sim":50.0, @@ -776915,31 +779994,19 @@ }, { "sim":50.0, - "partner":"6vll" - }, - { - "sim":50.0, - "partner":"5wg9" - }, - { - "sim":50.0, - "partner":"6v53" - }, - { - "sim":50.0, - "partner":"8edz" + "partner":"5wap" }, { "sim":50.0, - "partner":"6wij" + "partner":"6v56" }, { "sim":50.0, - "partner":"8dvo" + "partner":"6whm" }, { "sim":50.0, - "partner":"5wap" + "partner":"7kop" }, { "sim":50.0, @@ -776947,23 +780014,15 @@ }, { "sim":50.0, - "partner":"6v56" - }, - { - "sim":50.0, - "partner":"6whm" - }, - { - "sim":50.0, - "partner":"7kop" + "partner":"6v9e" }, { "sim":50.0, - "partner":"5w7u" + "partner":"6vbr" }, { "sim":50.0, - "partner":"6v9e" + "partner":"6vg9" }, { "sim":50.0, @@ -776971,11 +780030,11 @@ }, { "sim":50.0, - "partner":"6vbr" + "partner":"8e21" }, { "sim":50.0, - "partner":"6vg9" + "partner":"5w7u" }, { "sim":50.0, @@ -776991,31 +780050,35 @@ }, { "sim":50.0, - "partner":"8e21" + "partner":"4p9g" }, { "sim":50.0, - "partner":"4p9g" + "partner":"5wfw" }, { "sim":50.0, - "partner":"5wfw" + "partner":"8dqs" }, { "sim":50.0, "partner":"5deb" }, + { + "sim":50.0, + "partner":"7kbc" + }, { "sim":50.0, "partner":"5dbs" }, { "sim":50.0, - "partner":"7kbc" + "partner":"6v6x" }, { "sim":50.0, - "partner":"5w9g" + "partner":"6vjh" }, { "sim":50.0, @@ -777023,35 +780086,35 @@ }, { "sim":50.0, - "partner":"8dqs" + "partner":"8dpj" }, { "sim":50.0, - "partner":"5vqn" + "partner":"8dtw" }, { "sim":50.0, - "partner":"5wdw" + "partner":"5w9g" }, { "sim":50.0, - "partner":"5wfz" + "partner":"7kny" }, { "sim":50.0, - "partner":"6v6x" + "partner":"7lp8" }, { "sim":50.0, - "partner":"6vjh" + "partner":"5vqn" }, { "sim":50.0, - "partner":"7kny" + "partner":"5wdw" }, { "sim":50.0, - "partner":"7lp8" + "partner":"5wfz" }, { "sim":50.0, @@ -777059,15 +780122,15 @@ }, { "sim":50.0, - "partner":"8dpj" + "partner":"8e1q" }, { "sim":50.0, - "partner":"8dtw" + "partner":"7uuh" }, { "sim":50.0, - "partner":"7uuh" + "partner":"7lm4" }, { "sim":50.0, @@ -777083,15 +780146,11 @@ }, { "sim":50.0, - "partner":"7lm4" - }, - { - "sim":50.0, - "partner":"8e1q" + "partner":"6vl3" }, { "sim":50.0, - "partner":"5vpt" + "partner":"6w7a" }, { "sim":50.0, @@ -777099,11 +780158,11 @@ }, { "sim":50.0, - "partner":"6vl3" + "partner":"8e4s" }, { "sim":50.0, - "partner":"6w7a" + "partner":"5vpt" }, { "sim":50.0, @@ -777111,27 +780170,27 @@ }, { "sim":50.0, - "partner":"5vp8" + "partner":"7k87" }, { "sim":50.0, - "partner":"5w92" + "partner":"7n47" }, { "sim":50.0, - "partner":"5wa6" + "partner":"5vp8" }, { "sim":50.0, - "partner":"7k87" + "partner":"5w92" }, { "sim":50.0, - "partner":"7n47" + "partner":"5wa6" }, { "sim":50.0, - "partner":"8e4s" + "partner":"8dip" }, { "sim":50.0, @@ -777147,7 +780206,7 @@ }, { "sim":50.0, - "partner":"5vrj" + "partner":"6wj4" }, { "sim":50.0, @@ -777155,11 +780214,11 @@ }, { "sim":50.0, - "partner":"8dip" + "partner":"5vrj" }, { "sim":50.0, - "partner":"6wj4" + "partner":"6ws3" }, { "sim":50.0, @@ -777167,7 +780226,7 @@ }, { "sim":50.0, - "partner":"6ws3" + "partner":"6viv" }, { "sim":50.0, @@ -777175,19 +780234,15 @@ }, { "sim":50.0, - "partner":"5w73" - }, - { - "sim":50.0, - "partner":"6viv" + "partner":"7k77" }, { "sim":50.0, - "partner":"7k77" + "partner":"7umr" }, { "sim":50.0, - "partner":"7umr" + "partner":"5w73" }, { "sim":50.0, @@ -777209,6 +780264,10 @@ "sim":50.0, "partner":"7mpf" }, + { + "sim":50.0, + "partner":"6vll" + }, { "sim":50.0, "partner":"7k0w" @@ -777217,6 +780276,26 @@ "sim":50.0, "partner":"7n55" }, + { + "sim":50.0, + "partner":"8edz" + }, + { + "sim":50.0, + "partner":"6v53" + }, + { + "sim":50.0, + "partner":"8dvo" + }, + { + "sim":50.0, + "partner":"6wij" + }, + { + "sim":50.0, + "partner":"5wg9" + }, { "sim":50.0, "partner":"3w2z" @@ -777247,19 +780326,19 @@ }, { "sim":50.0, - "partner":"3th5" + "partner":"4gzl" }, { "sim":50.0, - "partner":"4c76" + "partner":"4gzm" }, { "sim":50.0, - "partner":"4gzl" + "partner":"3th5" }, { "sim":50.0, - "partner":"4gzm" + "partner":"4c76" }, { "sim":50.0, @@ -777319,11 +780398,11 @@ }, { "sim":50.0, - "partner":"3c6h" + "partner":"8jnk" }, { "sim":50.0, - "partner":"8jnk" + "partner":"3c6h" }, { "sim":50.0, @@ -777335,11 +780414,11 @@ }, { "sim":50.0, - "partner":"6z0x" + "partner":"6z0y" }, { "sim":50.0, - "partner":"6z0y" + "partner":"6z0x" }, { "sim":50.0, @@ -777347,11 +780426,11 @@ }, { "sim":50.0, - "partner":"8jnr" + "partner":"2iuw" }, { "sim":50.0, - "partner":"2iuw" + "partner":"8jnr" }, { "sim":50.0, @@ -777375,15 +780454,15 @@ }, { "sim":50.0, - "partner":"3la7" + "partner":"3la2" }, { "sim":50.0, - "partner":"3la2" + "partner":"3la3" }, { "sim":50.0, - "partner":"3la3" + "partner":"3la7" }, { "sim":50.0, @@ -777445,10 +780524,6 @@ "sim":50.0, "partner":"7n8w" }, - { - "sim":50.0, - "partner":"4jyi" - }, { "sim":50.0, "partner":"4dm6" @@ -777473,21 +780548,25 @@ "sim":50.0, "partner":"4jyh" }, + { + "sim":50.0, + "partner":"4jyi" + }, { "sim":50.0, "partner":"4q20" }, { "sim":50.0, - "partner":"6jox" + "partner":"8pps" }, { "sim":50.0, - "partner":"5lom" + "partner":"6jox" }, { "sim":50.0, - "partner":"8pps" + "partner":"5lom" }, { "sim":50.0, @@ -777509,14 +780588,6 @@ "sim":50.0, "partner":"8e1a" }, - { - "sim":50.0, - "partner":"6hxo" - }, - { - "sim":50.0, - "partner":"3dbp" - }, { "sim":50.0, "partner":"3mo7" @@ -777539,12 +780610,20 @@ }, { "sim":50.0, - "partner":"2wk1" + "partner":"6hxo" + }, + { + "sim":50.0, + "partner":"3dbp" }, { "sim":50.0, "partner":"6ypa" }, + { + "sim":50.0, + "partner":"2wk1" + }, { "sim":50.0, "partner":"5nyb" @@ -777591,11 +780670,11 @@ }, { "sim":50.0, - "partner":"5ny7" + "partner":"7dbs" }, { "sim":50.0, - "partner":"7dbs" + "partner":"5ny7" }, { "sim":50.0, @@ -777637,10 +780716,6 @@ "sim":50.0, "partner":"6mni" }, - { - "sim":50.0, - "partner":"2ovb" - }, { "sim":50.0, "partner":"2ovf" @@ -777653,6 +780728,10 @@ "sim":50.0, "partner":"2ov8" }, + { + "sim":50.0, + "partner":"2ovb" + }, { "sim":50.0, "partner":"8rhv" @@ -777673,17 +780752,13 @@ "sim":50.0, "partner":"8rhu" }, - { - "sim":50.0, - "partner":"7xrt" - }, { "sim":50.0, "partner":"7xrv" }, { "sim":50.0, - "partner":"6wye" + "partner":"7xrt" }, { "sim":50.0, @@ -777701,6 +780776,10 @@ "sim":50.0, "partner":"7ra4" }, + { + "sim":50.0, + "partner":"6wye" + }, { "sim":50.0, "partner":"7z6b" @@ -777725,10 +780804,6 @@ "sim":50.0, "partner":"4rw5" }, - { - "sim":50.0, - "partner":"4pgc" - }, { "sim":50.0, "partner":"4pgd" @@ -777745,6 +780820,10 @@ "sim":50.0, "partner":"4pgb" }, + { + "sim":50.0, + "partner":"4pgc" + }, { "sim":50.0, "partner":"8tms" @@ -777763,19 +780842,19 @@ }, { "sim":50.0, - "partner":"8khm" + "partner":"3kck" }, { "sim":50.0, - "partner":"8khn" + "partner":"8khm" }, { "sim":50.0, - "partner":"8kho" + "partner":"8khn" }, { "sim":50.0, - "partner":"3kck" + "partner":"8kho" }, { "sim":50.0, @@ -777785,10 +780864,6 @@ "sim":50.0, "partner":"3u3j" }, - { - "sim":50.0, - "partner":"3u3r" - }, { "sim":50.0, "partner":"3u3k" @@ -777801,6 +780876,10 @@ "sim":50.0, "partner":"3u3o" }, + { + "sim":50.0, + "partner":"3u3r" + }, { "sim":50.0, "partner":"6l3w" @@ -777889,14 +780968,6 @@ "sim":50.0, "partner":"6unx" }, - { - "sim":50.0, - "partner":"2nq6" - }, - { - "sim":50.0, - "partner":"2nq7" - }, { "sim":50.0, "partner":"2b3k" @@ -777923,11 +780994,11 @@ }, { "sim":50.0, - "partner":"4xrw" + "partner":"6lzb" }, { "sim":50.0, - "partner":"6lzb" + "partner":"4xrw" }, { "sim":50.0, @@ -777941,6 +781012,14 @@ "sim":50.0, "partner":"2gz5" }, + { + "sim":50.0, + "partner":"2nq6" + }, + { + "sim":50.0, + "partner":"2nq7" + }, { "sim":50.0, "partner":"2qry" @@ -777981,14 +781060,6 @@ "sim":50.0, "partner":"6kxh" }, - { - "sim":50.0, - "partner":"5tyq" - }, - { - "sim":50.0, - "partner":"5u19" - }, { "sim":50.0, "partner":"5u0n" @@ -778019,27 +781090,27 @@ }, { "sim":50.0, - "partner":"8bfr" + "partner":"5tyq" }, { "sim":50.0, - "partner":"8bft" + "partner":"5u19" }, { "sim":50.0, - "partner":"7svq" + "partner":"8bfr" }, { "sim":50.0, - "partner":"7smi" + "partner":"8bft" }, { "sim":50.0, - "partner":"5glm" + "partner":"7svq" }, { "sim":50.0, - "partner":"5gln" + "partner":"7smi" }, { "sim":50.0, @@ -778069,6 +781140,14 @@ "sim":50.0, "partner":"5gll" }, + { + "sim":50.0, + "partner":"5glm" + }, + { + "sim":50.0, + "partner":"5gln" + }, { "sim":50.0, "partner":"5hs4" @@ -778087,11 +781166,11 @@ }, { "sim":50.0, - "partner":"1t9s" + "partner":"1tbf" }, { "sim":50.0, - "partner":"1tbf" + "partner":"1t9s" }, { "sim":50.0, @@ -778101,10 +781180,6 @@ "sim":50.0, "partner":"3i8v" }, - { - "sim":50.0, - "partner":"7ajm" - }, { "sim":50.0, "partner":"7a4r" @@ -778123,23 +781198,7 @@ }, { "sim":50.0, - "partner":"7a53" - }, - { - "sim":50.0, - "partner":"7ajw" - }, - { - "sim":50.0, - "partner":"7akb" - }, - { - "sim":50.0, - "partner":"7ajy" - }, - { - "sim":50.0, - "partner":"7a5l" + "partner":"7ajm" }, { "sim":50.0, @@ -778201,13 +781260,29 @@ "sim":50.0, "partner":"7aka" }, + { + "sim":50.0, + "partner":"7a53" + }, { "sim":50.0, "partner":"7akl" }, { "sim":50.0, - "partner":"8tne" + "partner":"7ajw" + }, + { + "sim":50.0, + "partner":"7akb" + }, + { + "sim":50.0, + "partner":"7ajy" + }, + { + "sim":50.0, + "partner":"7a5l" }, { "sim":50.0, @@ -778217,6 +781292,10 @@ "sim":50.0, "partner":"1xp0" }, + { + "sim":50.0, + "partner":"8tne" + }, { "sim":50.0, "partner":"3wcg" @@ -778289,10 +781368,6 @@ "sim":50.0, "partner":"3a16" }, - { - "sim":50.0, - "partner":"2iua" - }, { "sim":50.0, "partner":"6j27" @@ -778305,6 +781380,10 @@ "sim":50.0, "partner":"2iu9" }, + { + "sim":50.0, + "partner":"2iua" + }, { "sim":50.0, "partner":"6j28" @@ -778345,10 +781424,6 @@ "sim":50.0, "partner":"8if7" }, - { - "sim":50.0, - "partner":"2o0h" - }, { "sim":50.0, "partner":"2o0j" @@ -778359,7 +781434,7 @@ }, { "sim":50.0, - "partner":"8a7h" + "partner":"2o0h" }, { "sim":50.0, @@ -778379,7 +781454,7 @@ }, { "sim":50.0, - "partner":"5hxu" + "partner":"8a7h" }, { "sim":50.0, @@ -778399,23 +781474,27 @@ }, { "sim":50.0, - "partner":"6zgp" + "partner":"5hxu" }, { "sim":50.0, - "partner":"6y8j" + "partner":"6y9d" }, { "sim":50.0, - "partner":"6y9c" + "partner":"6zgp" }, { "sim":50.0, - "partner":"6y9d" + "partner":"6y8s" }, { "sim":50.0, - "partner":"6y8s" + "partner":"6y8j" + }, + { + "sim":50.0, + "partner":"6y9c" }, { "sim":50.0, @@ -778447,11 +781526,11 @@ }, { "sim":50.0, - "partner":"7sc6" + "partner":"7scq" }, { "sim":50.0, - "partner":"7scq" + "partner":"7sc6" }, { "sim":50.0, @@ -778459,11 +781538,11 @@ }, { "sim":50.0, - "partner":"7k64" + "partner":"6m7l" }, { "sim":50.0, - "partner":"6m7l" + "partner":"7k64" }, { "sim":50.0, @@ -778521,10 +781600,6 @@ "sim":50.0, "partner":"3wy0" }, - { - "sim":50.0, - "partner":"4euh" - }, { "sim":50.0, "partner":"4eue" @@ -778535,7 +781610,7 @@ }, { "sim":50.0, - "partner":"4w4t" + "partner":"4euh" }, { "sim":50.0, @@ -778543,7 +781618,11 @@ }, { "sim":50.0, - "partner":"4u7w" + "partner":"8ukz" + }, + { + "sim":50.0, + "partner":"4w4t" }, { "sim":50.0, @@ -778551,7 +781630,7 @@ }, { "sim":50.0, - "partner":"8ukz" + "partner":"4u7w" }, { "sim":50.0, @@ -778573,10 +781652,6 @@ "sim":50.0, "partner":"2zvi" }, - { - "sim":50.0, - "partner":"5cu7" - }, { "sim":50.0, "partner":"4fdt" @@ -778607,7 +781682,7 @@ }, { "sim":50.0, - "partner":"5d40" + "partner":"5cu7" }, { "sim":50.0, @@ -778615,19 +781690,19 @@ }, { "sim":50.0, - "partner":"2wio" + "partner":"5d40" }, { "sim":50.0, - "partner":"6n67" + "partner":"2wio" }, { "sim":50.0, - "partner":"5y0o" + "partner":"6n67" }, { "sim":50.0, - "partner":"4q6q" + "partner":"5y0o" }, { "sim":50.0, @@ -778661,6 +781736,10 @@ "sim":50.0, "partner":"4q6p" }, + { + "sim":50.0, + "partner":"4q6q" + }, { "sim":50.0, "partner":"8euk" @@ -778743,15 +781822,15 @@ }, { "sim":50.0, - "partner":"2gps" + "partner":"2gpw" }, { "sim":50.0, - "partner":"6oi9" + "partner":"2gps" }, { "sim":50.0, - "partner":"2gpw" + "partner":"6oi9" }, { "sim":50.0, @@ -778831,23 +781910,23 @@ }, { "sim":50.0, - "partner":"2cj9" + "partner":"2cja" }, { "sim":50.0, - "partner":"5o3m" + "partner":"2cim" }, { "sim":50.0, - "partner":"2cja" + "partner":"2cjb" }, { "sim":50.0, - "partner":"2cim" + "partner":"5o3m" }, { "sim":50.0, - "partner":"2cjb" + "partner":"2cj9" }, { "sim":50.0, @@ -778917,10 +781996,6 @@ "sim":50.0, "partner":"4lh3" }, - { - "sim":50.0, - "partner":"2q5l" - }, { "sim":50.0, "partner":"2q5o" @@ -778939,11 +782014,11 @@ }, { "sim":50.0, - "partner":"6vgs" + "partner":"2q5l" }, { "sim":50.0, - "partner":"2vbg" + "partner":"6vgs" }, { "sim":50.0, @@ -778953,6 +782028,10 @@ "sim":50.0, "partner":"2vbf" }, + { + "sim":50.0, + "partner":"2vbg" + }, { "sim":50.0, "partner":"3cpe" @@ -779007,15 +782086,15 @@ }, { "sim":50.0, - "partner":"5lj7" + "partner":"5lil" }, { "sim":50.0, - "partner":"5lil" + "partner":"5lj6" }, { "sim":50.0, - "partner":"5lj6" + "partner":"5lj7" }, { "sim":50.0, @@ -779047,23 +782126,23 @@ }, { "sim":50.0, - "partner":"7vzz" + "partner":"7vzq" }, { "sim":50.0, - "partner":"7vzu" + "partner":"7vx0" }, { "sim":50.0, - "partner":"7vzq" + "partner":"7vzy" }, { "sim":50.0, - "partner":"7vx0" + "partner":"7vzz" }, { "sim":50.0, - "partner":"7vzy" + "partner":"7vzu" }, { "sim":50.0, @@ -779099,15 +782178,15 @@ }, { "sim":50.0, - "partner":"6tsh" + "partner":"6tsk" }, { "sim":50.0, - "partner":"6tte" + "partner":"6tsh" }, { "sim":50.0, - "partner":"6tsk" + "partner":"6tte" }, { "sim":50.0, @@ -779234,90 +782313,90 @@ "alpha-helical barrel" ], "keywords":[ - "require", - "monomeric", - "channels", - "seeded", - "peptide", - "accelerating", - "including", - "pipelines", + "made", + "open", + "genes", + "defined", + "escherichia", + "minimizes", + "families", + "rapidly", + "short", + "protein", + "six", + "fully", + "novo", "throughout", - "parallel", + "match", + "motifs", + "pipelines", + "two", + "helices", + "adjacent", + "antiparallel", + "characterized", + "however", + "soluble", + "starting", + "define", + "residues", + "targets", + "connected", + "layer", + "bind", + "proteins", + "accelerating", + "process", + "accuracy", "outer", + "small", + "barrel", + "longer", + "computational", + "including", + "peptide", + "design", "sampling", - "sequences", - "expression", - "bind", - "synthetic", + "onto", + "express", "packed", - "escherichia", + "loops", + "maintained", + "oligomeric", + "namely", + "validated", + "connectors", + "coli", + "parallel", "building", - "however", - "starting", + "seeded", + "channels", + "states", + "sequence", + "peptides", + "describe", + "assemblies", + "advancing", + "central", "average", - "longer", - "connectors", - "proteins", "models", - "process", - "de", - "characterized", - "rapidly", + "sequences", + "require", "efficient", - "open", - "small", - "short", - "maintained", - "fully", - "made", - "match", - "onto", + "loop", "structures", + "de", + "70", + "synthetic", + "monomeric", "give", - "motifs", "molecules", - "layer", - "loops", - "connected", - "defined", - "families", - "assemblies", - "coli", - "70", - "namely", - "define", - "six", - "design", - "minimizes", - "express", - "soluble", - "states", "routes", - "describe", "high", - "sequence", - "genes", - "accuracy", - "designs", - "advancing", - "helices", - "barrels", - "novo", - "barrel", "sufficient", - "peptides", - "residues", - "adjacent", - "two", - "validated", - "antiparallel", - "central", - "protein", - "targets", - "computational", - "oligomeric", - "loop" + "expression", + "designs", + "barrels" ], "release_date":"2024-07-03", "publication":"\"Rationally seeded computational protein design of ɑ-helical barrels\", Nat.Chem.Biol., 20, 991-999", @@ -779362,11 +782441,11 @@ }, { "sim":57.0, - "partner":"8v2w" + "partner":"8v09" }, { "sim":57.0, - "partner":"8v09" + "partner":"8v2w" }, { "sim":56.0, @@ -779386,19 +782465,19 @@ }, { "sim":55.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":55.0, - "partner":"8w05" + "partner":"8w06" }, { "sim":53.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":53.0, - "partner":"8w08" + "partner":"8v0a" }, { "sim":52.0, @@ -779422,11 +782501,11 @@ }, { "sim":50.0, - "partner":"8c66" + "partner":"8adx" }, { "sim":50.0, - "partner":"8adx" + "partner":"8c66" }, { "sim":50.0, @@ -779536,123 +782615,123 @@ }, { "sim":58.0, - "partner":"1xoq" + "partner":"1y2b" }, { "sim":58.0, - "partner":"6ind" + "partner":"6imt" }, { "sim":58.0, - "partner":"8w4r" + "partner":"1y2c" }, { "sim":58.0, - "partner":"1xor" + "partner":"8k4c" }, { "sim":58.0, - "partner":"3iak" + "partner":"6ink" }, { "sim":58.0, - "partner":"6imr" + "partner":"1y2d" }, { "sim":58.0, - "partner":"7cbj" + "partner":"1y2e" }, { "sim":58.0, - "partner":"1y2b" + "partner":"6inm" }, { "sim":58.0, - "partner":"6im6" + "partner":"6imb" }, { "sim":58.0, - "partner":"6imt" + "partner":"7cbq" }, { "sim":58.0, - "partner":"1y2c" + "partner":"7ysx" }, { "sim":58.0, - "partner":"1y2d" + "partner":"6imd" }, { "sim":58.0, - "partner":"6ink" + "partner":"8w4q" }, { "sim":58.0, - "partner":"1y2e" + "partner":"8w4r" }, { "sim":58.0, - "partner":"6inm" + "partner":"1y2k" }, { "sim":58.0, - "partner":"6imb" + "partner":"6imi" }, { "sim":58.0, - "partner":"8k4h" + "partner":"6imo" }, { "sim":58.0, - "partner":"7ysx" + "partner":"6lrm" }, { "sim":58.0, - "partner":"7cbq" + "partner":"1xom" }, { "sim":58.0, - "partner":"8k4c" + "partner":"1xon" }, { "sim":58.0, - "partner":"6imd" + "partner":"3k4s" }, { "sim":58.0, - "partner":"1y2k" + "partner":"7yqf" }, { "sim":58.0, - "partner":"1xom" + "partner":"6ind" }, { "sim":58.0, - "partner":"6imi" + "partner":"1xoq" }, { "sim":58.0, - "partner":"6imo" + "partner":"7cbj" }, { "sim":58.0, - "partner":"6lrm" + "partner":"6imr" }, { "sim":58.0, - "partner":"1xon" + "partner":"1xor" }, { "sim":58.0, - "partner":"3k4s" + "partner":"6im6" }, { "sim":58.0, - "partner":"7yqf" + "partner":"8k4h" }, { "sim":58.0, - "partner":"8w4q" + "partner":"3iak" }, { "sim":58.0, @@ -779670,10 +782749,6 @@ "sim":57.0, "partner":"7asw" }, - { - "sim":57.0, - "partner":"4evc" - }, { "sim":57.0, "partner":"3ta8" @@ -779686,6 +782761,10 @@ "sim":57.0, "partner":"4evb" }, + { + "sim":57.0, + "partner":"4evc" + }, { "sim":57.0, "partner":"5w10" @@ -779710,10 +782789,6 @@ "sim":57.0, "partner":"7qek" }, - { - "sim":57.0, - "partner":"6o98" - }, { "sim":57.0, "partner":"7jh2" @@ -779728,7 +782803,7 @@ }, { "sim":57.0, - "partner":"6fcn" + "partner":"6o98" }, { "sim":57.0, @@ -779736,11 +782811,7 @@ }, { "sim":57.0, - "partner":"7kqj" - }, - { - "sim":57.0, - "partner":"6vqf" + "partner":"6fcn" }, { "sim":57.0, @@ -779788,19 +782859,19 @@ }, { "sim":57.0, - "partner":"4xbz" + "partner":"6vqf" }, { "sim":57.0, - "partner":"2f9y" + "partner":"7kqj" }, { "sim":57.0, - "partner":"4mfj" + "partner":"4xbz" }, { "sim":57.0, - "partner":"4mfk" + "partner":"2f9y" }, { "sim":57.0, @@ -779808,19 +782879,23 @@ }, { "sim":57.0, - "partner":"6iix" + "partner":"4mfp" }, { "sim":57.0, - "partner":"4mfp" + "partner":"4mfq" }, { "sim":57.0, - "partner":"4mfq" + "partner":"4mfj" }, { "sim":57.0, - "partner":"4l2h" + "partner":"6iix" + }, + { + "sim":57.0, + "partner":"4mfk" }, { "sim":57.0, @@ -779831,12 +782906,12 @@ "partner":"4epq" }, { - "sim":56.0, - "partner":"1kft" + "sim":57.0, + "partner":"4l2h" }, { "sim":56.0, - "partner":"3rg6" + "partner":"1kft" }, { "sim":56.0, @@ -779850,6 +782925,10 @@ "sim":56.0, "partner":"2peo" }, + { + "sim":56.0, + "partner":"3rg6" + }, { "sim":56.0, "partner":"6ede" @@ -779874,10 +782953,6 @@ "sim":56.0, "partner":"6vly" }, - { - "sim":56.0, - "partner":"3g3d" - }, { "sim":56.0, "partner":"3bvj" @@ -779894,6 +782969,10 @@ "sim":56.0, "partner":"4hkp" }, + { + "sim":56.0, + "partner":"3g3d" + }, { "sim":56.0, "partner":"3mcm" @@ -779908,79 +782987,79 @@ }, { "sim":56.0, - "partner":"8gf0" + "partner":"7lam" }, { "sim":56.0, - "partner":"8gfp" + "partner":"8gfb" }, { "sim":56.0, - "partner":"8gf1" + "partner":"8gfc" }, { "sim":56.0, - "partner":"8gfq" + "partner":"8gfd" }, { "sim":56.0, - "partner":"8gfs" + "partner":"8gfe" }, { "sim":56.0, - "partner":"7lam" + "partner":"7laq" }, { "sim":56.0, - "partner":"7laq" + "partner":"8gff" }, { "sim":56.0, - "partner":"8gfb" + "partner":"8gfg" }, { "sim":56.0, - "partner":"8gfc" + "partner":"8gfh" }, { "sim":56.0, - "partner":"8gfd" + "partner":"8gfi" }, { "sim":56.0, - "partner":"8gfe" + "partner":"8gfj" }, { "sim":56.0, - "partner":"8gff" + "partner":"8gfl" }, { "sim":56.0, - "partner":"8gfg" + "partner":"8gfm" }, { "sim":56.0, - "partner":"8gfh" + "partner":"8gez" }, { "sim":56.0, - "partner":"8gfi" + "partner":"8gf0" }, { "sim":56.0, - "partner":"8gfj" + "partner":"8gfp" }, { "sim":56.0, - "partner":"8gfl" + "partner":"8gf1" }, { "sim":56.0, - "partner":"8gfm" + "partner":"8gfq" }, { "sim":56.0, - "partner":"8gez" + "partner":"8gfs" }, { "sim":55.0, @@ -780160,15 +783239,15 @@ }, { "sim":55.0, - "partner":"6vkk" + "partner":"6vko" }, { "sim":55.0, - "partner":"6vkq" + "partner":"6vkk" }, { "sim":55.0, - "partner":"6vko" + "partner":"6vkq" }, { "sim":55.0, @@ -780206,10 +783285,6 @@ "sim":55.0, "partner":"2o1w" }, - { - "sim":55.0, - "partner":"5kdn" - }, { "sim":55.0, "partner":"5kds" @@ -780220,11 +783295,11 @@ }, { "sim":55.0, - "partner":"5jjq" + "partner":"5kdn" }, { "sim":55.0, - "partner":"5tsh" + "partner":"5jjq" }, { "sim":55.0, @@ -780234,6 +783309,10 @@ "sim":55.0, "partner":"5tsg" }, + { + "sim":55.0, + "partner":"5tsh" + }, { "sim":55.0, "partner":"2o1u" @@ -780260,15 +783339,15 @@ }, { "sim":54.0, - "partner":"6tq2" + "partner":"4azn" }, { "sim":54.0, - "partner":"4azn" + "partner":"6tq1" }, { "sim":54.0, - "partner":"6tq1" + "partner":"6tq2" }, { "sim":54.0, @@ -780306,14 +783385,6 @@ "sim":54.0, "partner":"8fy0" }, - { - "sim":54.0, - "partner":"6tlm" - }, - { - "sim":54.0, - "partner":"6tlq" - }, { "sim":54.0, "partner":"6tlt" @@ -780348,23 +783419,23 @@ }, { "sim":54.0, - "partner":"4lbd" + "partner":"6tlm" }, { "sim":54.0, - "partner":"3lbd" + "partner":"6tlq" }, { "sim":54.0, - "partner":"2lbd" + "partner":"4lbd" }, { "sim":54.0, - "partner":"5ds3" + "partner":"3lbd" }, { "sim":54.0, - "partner":"6bhv" + "partner":"2lbd" }, { "sim":54.0, @@ -780374,10 +783445,6 @@ "sim":54.0, "partner":"2f9t" }, - { - "sim":54.0, - "partner":"2f9w" - }, { "sim":54.0, "partner":"8fz1" @@ -780388,12 +783455,16 @@ }, { "sim":54.0, - "partner":"6nrf" + "partner":"2f9w" }, { "sim":54.0, "partner":"8fyz" }, + { + "sim":54.0, + "partner":"6nrf" + }, { "sim":54.0, "partner":"6nrg" @@ -780410,6 +783481,14 @@ "sim":54.0, "partner":"6nrj" }, + { + "sim":54.0, + "partner":"6bhv" + }, + { + "sim":54.0, + "partner":"5ds3" + }, { "sim":54.0, "partner":"5jo8" @@ -780482,14 +783561,6 @@ "sim":54.0, "partner":"4xzz" }, - { - "sim":54.0, - "partner":"5gg5" - }, - { - "sim":54.0, - "partner":"5xd1" - }, { "sim":54.0, "partner":"5gg6" @@ -780504,27 +783575,27 @@ }, { "sim":54.0, - "partner":"5gg7" + "partner":"6m6y" }, { "sim":54.0, - "partner":"5xd4" + "partner":"5gg7" }, { "sim":54.0, - "partner":"5xd5" + "partner":"5xd4" }, { "sim":54.0, - "partner":"6m6y" + "partner":"6m65" }, { "sim":54.0, - "partner":"5gg8" + "partner":"5xd5" }, { "sim":54.0, - "partner":"6m65" + "partner":"5gg8" }, { "sim":54.0, @@ -780556,7 +783627,11 @@ }, { "sim":54.0, - "partner":"5g6t" + "partner":"5gg5" + }, + { + "sim":54.0, + "partner":"5xd1" }, { "sim":54.0, @@ -780582,6 +783657,10 @@ "sim":54.0, "partner":"5g5k" }, + { + "sim":54.0, + "partner":"5g6t" + }, { "sim":54.0, "partner":"7a19" @@ -780632,27 +783711,27 @@ }, { "sim":54.0, - "partner":"6ry0" + "partner":"6ry5" }, { "sim":54.0, - "partner":"6ry1" + "partner":"6ry6" }, { "sim":54.0, - "partner":"6ry2" + "partner":"6ry7" }, { "sim":54.0, - "partner":"6ry5" + "partner":"6ry0" }, { "sim":54.0, - "partner":"6ry6" + "partner":"6ry1" }, { "sim":54.0, - "partner":"6ry7" + "partner":"6ry2" }, { "sim":54.0, @@ -780754,10 +783833,6 @@ "sim":53.0, "partner":"2bze" }, - { - "sim":53.0, - "partner":"5hso" - }, { "sim":53.0, "partner":"5x7z" @@ -780770,6 +783845,10 @@ "sim":53.0, "partner":"5hsm" }, + { + "sim":53.0, + "partner":"5hso" + }, { "sim":53.0, "partner":"3s9f" @@ -780808,23 +783887,23 @@ }, { "sim":53.0, - "partner":"4njh" + "partner":"4njj" }, { "sim":53.0, - "partner":"4nji" + "partner":"4njk" }, { "sim":53.0, - "partner":"4njj" + "partner":"4njg" }, { "sim":53.0, - "partner":"4njk" + "partner":"4njh" }, { "sim":53.0, - "partner":"4njg" + "partner":"4nji" }, { "sim":53.0, @@ -780836,27 +783915,27 @@ }, { "sim":53.0, - "partner":"3la7" + "partner":"3la2" }, { "sim":53.0, - "partner":"3la2" + "partner":"3la3" }, { "sim":53.0, - "partner":"3la3" + "partner":"3la7" }, { "sim":53.0, - "partner":"4bmx" + "partner":"4bmz" }, { "sim":53.0, - "partner":"4bmy" + "partner":"4bmx" }, { "sim":53.0, - "partner":"4bmz" + "partner":"4bmy" }, { "sim":53.0, @@ -780928,27 +784007,27 @@ }, { "sim":53.0, - "partner":"6mq9" + "partner":"6mqb" }, { "sim":53.0, - "partner":"6mqb" + "partner":"6mqk" }, { "sim":53.0, - "partner":"6mqk" + "partner":"6mq9" }, { "sim":53.0, - "partner":"7enb" + "partner":"7emz" }, { "sim":53.0, - "partner":"7de2" + "partner":"7enb" }, { "sim":53.0, - "partner":"7emz" + "partner":"7de2" }, { "sim":53.0, @@ -780960,19 +784039,19 @@ }, { "sim":53.0, - "partner":"3nha" + "partner":"3nh6" }, { "sim":53.0, - "partner":"3nhb" + "partner":"3nh9" }, { "sim":53.0, - "partner":"3nh6" + "partner":"3nha" }, { "sim":53.0, - "partner":"3nh9" + "partner":"3nhb" }, { "sim":53.0, @@ -781036,11 +784115,11 @@ }, { "sim":53.0, - "partner":"3auz" + "partner":"5jyp" }, { "sim":53.0, - "partner":"5jyp" + "partner":"3auz" }, { "sim":53.0, @@ -781050,14 +784129,6 @@ "sim":53.0, "partner":"6gx7" }, - { - "sim":53.0, - "partner":"5tyq" - }, - { - "sim":53.0, - "partner":"5u19" - }, { "sim":53.0, "partner":"5u0n" @@ -781076,27 +784147,27 @@ }, { "sim":53.0, - "partner":"6vwr" + "partner":"5tyq" }, { "sim":53.0, - "partner":"6vwq" + "partner":"5u19" }, { "sim":53.0, - "partner":"1t9s" + "partner":"6vwq" }, { "sim":53.0, - "partner":"1tbf" + "partner":"6vwr" }, { "sim":53.0, - "partner":"1x19" + "partner":"1tbf" }, { "sim":53.0, - "partner":"1x1a" + "partner":"1t9s" }, { "sim":53.0, @@ -781110,6 +784181,14 @@ "sim":53.0, "partner":"1x1d" }, + { + "sim":53.0, + "partner":"1x19" + }, + { + "sim":53.0, + "partner":"1x1a" + }, { "sim":53.0, "partner":"1xoz" @@ -781150,10 +784229,6 @@ "sim":53.0, "partner":"4myg" }, - { - "sim":53.0, - "partner":"2iua" - }, { "sim":53.0, "partner":"2iu8" @@ -781164,15 +784239,15 @@ }, { "sim":53.0, - "partner":"6k3f" + "partner":"2iua" }, { "sim":53.0, - "partner":"7n06" + "partner":"6k3f" }, { "sim":53.0, - "partner":"7azd" + "partner":"7n06" }, { "sim":53.0, @@ -781188,11 +784263,11 @@ }, { "sim":53.0, - "partner":"5f3w" + "partner":"7aze" }, { "sim":53.0, - "partner":"7aze" + "partner":"5f3w" }, { "sim":53.0, @@ -781216,11 +784291,11 @@ }, { "sim":53.0, - "partner":"5x06" + "partner":"7azg" }, { "sim":53.0, - "partner":"7azg" + "partner":"5x06" }, { "sim":53.0, @@ -781228,11 +784303,11 @@ }, { "sim":53.0, - "partner":"6s31" + "partner":"7azd" }, { "sim":53.0, - "partner":"6s0g" + "partner":"6s31" }, { "sim":53.0, @@ -781242,6 +784317,10 @@ "sim":53.0, "partner":"6s23" }, + { + "sim":53.0, + "partner":"6s0g" + }, { "sim":53.0, "partner":"7ah4" @@ -781264,11 +784343,11 @@ }, { "sim":53.0, - "partner":"4pk6" + "partner":"6r63" }, { "sim":53.0, - "partner":"6r63" + "partner":"4pk6" }, { "sim":53.0, @@ -781308,11 +784387,11 @@ }, { "sim":53.0, - "partner":"8il0" + "partner":"8ila" }, { "sim":53.0, - "partner":"8ila" + "partner":"8il0" }, { "sim":53.0, @@ -781412,23 +784491,23 @@ }, { "sim":53.0, - "partner":"2cj9" + "partner":"2cja" }, { "sim":53.0, - "partner":"5o3m" + "partner":"2cim" }, { "sim":53.0, - "partner":"2cja" + "partner":"2cjb" }, { "sim":53.0, - "partner":"2cim" + "partner":"5o3m" }, { "sim":53.0, - "partner":"2cjb" + "partner":"2cj9" }, { "sim":53.0, @@ -781466,10 +784545,6 @@ "sim":53.0, "partner":"5swi" }, - { - "sim":53.0, - "partner":"7wlg" - }, { "sim":53.0, "partner":"7wj9" @@ -781498,6 +784573,10 @@ "sim":53.0, "partner":"7wjf" }, + { + "sim":53.0, + "partner":"7wlg" + }, { "sim":53.0, "partner":"7jvi" @@ -781524,11 +784603,11 @@ }, { "sim":52.0, - "partner":"2ese" + "partner":"2es6" }, { "sim":52.0, - "partner":"2es6" + "partner":"2ese" }, { "sim":52.0, @@ -781570,10 +784649,6 @@ "sim":52.0, "partner":"4yif" }, - { - "sim":52.0, - "partner":"2vbq" - }, { "sim":52.0, "partner":"1s3z" @@ -781588,11 +784663,7 @@ }, { "sim":52.0, - "partner":"5scp" - }, - { - "sim":52.0, - "partner":"5scq" + "partner":"2vbq" }, { "sim":52.0, @@ -781694,6 +784765,14 @@ "sim":52.0, "partner":"5sco" }, + { + "sim":52.0, + "partner":"5scp" + }, + { + "sim":52.0, + "partner":"5scq" + }, { "sim":52.0, "partner":"7tz1" @@ -781728,19 +784807,19 @@ }, { "sim":52.0, - "partner":"5n7o" + "partner":"6hry" }, { "sim":52.0, - "partner":"6hry" + "partner":"5n7o" }, { "sim":52.0, - "partner":"5n1c" + "partner":"6hrz" }, { "sim":52.0, - "partner":"6hrz" + "partner":"5n1c" }, { "sim":52.0, @@ -781874,10 +784953,6 @@ "sim":52.0, "partner":"3oxh" }, - { - "sim":52.0, - "partner":"5lto" - }, { "sim":52.0, "partner":"5lt9" @@ -781898,6 +784973,10 @@ "sim":52.0, "partner":"4o1f" }, + { + "sim":52.0, + "partner":"5lto" + }, { "sim":52.0, "partner":"4hu3" @@ -781920,11 +784999,11 @@ }, { "sim":52.0, - "partner":"2jfp" + "partner":"6y64" }, { "sim":52.0, - "partner":"6y64" + "partner":"2jfp" }, { "sim":52.0, @@ -781972,51 +785051,51 @@ }, { "sim":52.0, - "partner":"3sie" + "partner":"4i9z" }, { "sim":52.0, - "partner":"4g2w" + "partner":"4ia0" }, { "sim":52.0, - "partner":"8w4s" + "partner":"4oew" }, { "sim":52.0, - "partner":"4g2y" + "partner":"4oex" }, { "sim":52.0, - "partner":"8w4t" + "partner":"6iwi" }, { "sim":52.0, - "partner":"4i9z" + "partner":"8w4s" }, { "sim":52.0, - "partner":"4ia0" + "partner":"8w4t" }, { "sim":52.0, - "partner":"4oew" + "partner":"3shy" }, { "sim":52.0, - "partner":"4oex" + "partner":"3shz" }, { "sim":52.0, - "partner":"6iwi" + "partner":"3sie" }, { "sim":52.0, - "partner":"3shy" + "partner":"4g2w" }, { "sim":52.0, - "partner":"3shz" + "partner":"4g2y" }, { "sim":52.0, @@ -782068,11 +785147,11 @@ }, { "sim":52.0, - "partner":"4gpu" + "partner":"4gps" }, { "sim":52.0, - "partner":"4gps" + "partner":"4gpu" }, { "sim":52.0, @@ -782128,11 +785207,11 @@ }, { "sim":52.0, - "partner":"7f79" + "partner":"7f77" }, { "sim":52.0, - "partner":"7f77" + "partner":"7f79" }, { "sim":52.0, @@ -782210,10 +785289,6 @@ "sim":52.0, "partner":"6a50" }, - { - "sim":52.0, - "partner":"6p00" - }, { "sim":52.0, "partner":"7ju0" @@ -782242,6 +785317,10 @@ "sim":52.0, "partner":"2e4g" }, + { + "sim":52.0, + "partner":"6p00" + }, { "sim":52.0, "partner":"8jor" @@ -782252,15 +785331,15 @@ }, { "sim":52.0, - "partner":"8hdf" + "partner":"8hd4" }, { "sim":52.0, - "partner":"8iqu" + "partner":"8hdf" }, { "sim":52.0, - "partner":"8hd4" + "partner":"8iqu" }, { "sim":52.0, @@ -782392,11 +785471,11 @@ }, { "sim":51.0, - "partner":"3imo" + "partner":"2y78" }, { "sim":51.0, - "partner":"2y78" + "partner":"3imo" }, { "sim":51.0, @@ -782408,15 +785487,15 @@ }, { "sim":51.0, - "partner":"3qna" + "partner":"3qn0" }, { "sim":51.0, - "partner":"3qn0" + "partner":"3qn9" }, { "sim":51.0, - "partner":"3qn9" + "partner":"3qna" }, { "sim":51.0, @@ -782450,10 +785529,6 @@ "sim":51.0, "partner":"2ydw" }, - { - "sim":51.0, - "partner":"4a9j" - }, { "sim":51.0, "partner":"4a9m" @@ -782498,6 +785573,10 @@ "sim":51.0, "partner":"4a9f" }, + { + "sim":51.0, + "partner":"4a9j" + }, { "sim":51.0, "partner":"6lag" @@ -782518,14 +785597,6 @@ "sim":51.0, "partner":"4zwr" }, - { - "sim":51.0, - "partner":"5wqi" - }, - { - "sim":51.0, - "partner":"3sw1" - }, { "sim":51.0, "partner":"5j3w" @@ -782564,11 +785635,11 @@ }, { "sim":51.0, - "partner":"7r4s" + "partner":"6gg9" }, { "sim":51.0, - "partner":"6gg9" + "partner":"7r4s" }, { "sim":51.0, @@ -782576,12 +785647,20 @@ }, { "sim":51.0, - "partner":"2o4e" + "partner":"5wqi" + }, + { + "sim":51.0, + "partner":"3sw1" }, { "sim":51.0, "partner":"2ozn" }, + { + "sim":51.0, + "partner":"2o4e" + }, { "sim":51.0, "partner":"5luv" @@ -782596,15 +785675,15 @@ }, { "sim":51.0, - "partner":"5eri" + "partner":"3ph3" }, { "sim":51.0, - "partner":"3ph3" + "partner":"3ph4" }, { "sim":51.0, - "partner":"3ph4" + "partner":"5eri" }, { "sim":51.0, @@ -782672,11 +785751,11 @@ }, { "sim":51.0, - "partner":"5ujf" + "partner":"5zrt" }, { "sim":51.0, - "partner":"5zrt" + "partner":"5ujf" }, { "sim":51.0, @@ -782696,19 +785775,19 @@ }, { "sim":51.0, - "partner":"6kz6" + "partner":"8pwz" }, { "sim":51.0, - "partner":"8pwz" + "partner":"6kz6" }, { "sim":51.0, - "partner":"4o8t" + "partner":"4o8l" }, { "sim":51.0, - "partner":"4o8l" + "partner":"4o8t" }, { "sim":51.0, @@ -782888,15 +785967,15 @@ }, { "sim":51.0, - "partner":"7d9v" + "partner":"7d8h" }, { "sim":51.0, - "partner":"7d8p" + "partner":"7d9v" }, { "sim":51.0, - "partner":"7d8h" + "partner":"7d8p" }, { "sim":51.0, @@ -782910,10 +785989,6 @@ "sim":51.0, "partner":"3kmr" }, - { - "sim":51.0, - "partner":"4jyi" - }, { "sim":51.0, "partner":"1sny" @@ -782942,6 +786017,10 @@ "sim":51.0, "partner":"4jyh" }, + { + "sim":51.0, + "partner":"4jyi" + }, { "sim":51.0, "partner":"4q20" @@ -783000,11 +786079,11 @@ }, { "sim":51.0, - "partner":"6hxo" + "partner":"6hxn" }, { "sim":51.0, - "partner":"6hxn" + "partner":"6hxo" }, { "sim":51.0, @@ -783052,24 +786131,12 @@ }, { "sim":51.0, - "partner":"5coq" - }, - { - "sim":51.0, - "partner":"5cpb" - }, - { - "sim":51.0, - "partner":"5mtr" + "partner":"4oxk" }, { "sim":51.0, "partner":"5ugt" }, - { - "sim":51.0, - "partner":"4oxk" - }, { "sim":51.0, "partner":"5ugu" @@ -783080,15 +786147,15 @@ }, { "sim":51.0, - "partner":"4oxn" + "partner":"6yuu" }, { "sim":51.0, - "partner":"4oyr" + "partner":"4oxn" }, { "sim":51.0, - "partner":"6yuu" + "partner":"4oyr" }, { "sim":51.0, @@ -783114,33 +786181,49 @@ "sim":51.0, "partner":"5cp8" }, + { + "sim":51.0, + "partner":"5mtr" + }, { "sim":51.0, "partner":"5ugs" }, { "sim":51.0, - "partner":"7a61" + "partner":"5cpb" }, { "sim":51.0, - "partner":"5uj3" + "partner":"5coq" }, { "sim":51.0, - "partner":"5uj4" + "partner":"8rwq" }, { "sim":51.0, "partner":"6mnp" }, + { + "sim":51.0, + "partner":"8rwr" + }, + { + "sim":51.0, + "partner":"5uj3" + }, { "sim":51.0, "partner":"6d15" }, { "sim":51.0, - "partner":"5ul8" + "partner":"8rws" + }, + { + "sim":51.0, + "partner":"5uj4" }, { "sim":51.0, @@ -783154,6 +786237,10 @@ "sim":51.0, "partner":"6d17" }, + { + "sim":51.0, + "partner":"5ul8" + }, { "sim":51.0, "partner":"6d18" @@ -783208,15 +786295,15 @@ }, { "sim":51.0, - "partner":"8rwq" + "partner":"6mey" }, { "sim":51.0, - "partner":"6mey" + "partner":"6v1j" }, { "sim":51.0, - "partner":"6v1j" + "partner":"8aki" }, { "sim":51.0, @@ -783224,7 +786311,7 @@ }, { "sim":51.0, - "partner":"8aki" + "partner":"8akj" }, { "sim":51.0, @@ -783236,7 +786323,7 @@ }, { "sim":51.0, - "partner":"8akj" + "partner":"8akk" }, { "sim":51.0, @@ -783244,15 +786331,23 @@ }, { "sim":51.0, - "partner":"8akk" + "partner":"8akl" }, { "sim":51.0, - "partner":"8akl" + "partner":"8akm" }, { "sim":51.0, - "partner":"8akm" + "partner":"7a61" + }, + { + "sim":51.0, + "partner":"8rwo" + }, + { + "sim":51.0, + "partner":"8rwp" }, { "sim":51.0, @@ -783280,11 +786375,11 @@ }, { "sim":51.0, - "partner":"3ta4" + "partner":"3t9w" }, { "sim":51.0, - "partner":"3t9w" + "partner":"3ta4" }, { "sim":51.0, @@ -783332,19 +786427,19 @@ }, { "sim":51.0, - "partner":"8khm" + "partner":"7e4m" }, { "sim":51.0, - "partner":"8khn" + "partner":"8khm" }, { "sim":51.0, - "partner":"8kho" + "partner":"8khn" }, { "sim":51.0, - "partner":"7e4m" + "partner":"8kho" }, { "sim":51.0, @@ -783430,10 +786525,6 @@ "sim":51.0, "partner":"4n57" }, - { - "sim":51.0, - "partner":"3aio" - }, { "sim":51.0, "partner":"3aik" @@ -783456,11 +786547,7 @@ }, { "sim":51.0, - "partner":"7v52" - }, - { - "sim":51.0, - "partner":"7v54" + "partner":"3aio" }, { "sim":51.0, @@ -783480,16 +786567,24 @@ }, { "sim":51.0, - "partner":"1w2n" + "partner":"7v52" }, { "sim":51.0, - "partner":"1w2o" + "partner":"7v54" }, { "sim":51.0, "partner":"6djt" }, + { + "sim":51.0, + "partner":"1w2n" + }, + { + "sim":51.0, + "partner":"1w2o" + }, { "sim":51.0, "partner":"1w28" @@ -783552,15 +786647,15 @@ }, { "sim":51.0, - "partner":"4bf9" + "partner":"5z76" }, { "sim":51.0, - "partner":"4bfa" + "partner":"4bf9" }, { "sim":51.0, - "partner":"5z76" + "partner":"4bfa" }, { "sim":51.0, @@ -783580,11 +786675,11 @@ }, { "sim":51.0, - "partner":"3wcf" + "partner":"3wc9" }, { "sim":51.0, - "partner":"3wc9" + "partner":"3wcf" }, { "sim":51.0, @@ -783706,14 +786801,6 @@ "sim":51.0, "partner":"8if7" }, - { - "sim":51.0, - "partner":"4q3r" - }, - { - "sim":51.0, - "partner":"4q42" - }, { "sim":51.0, "partner":"4q3s" @@ -783748,11 +786835,15 @@ }, { "sim":51.0, - "partner":"8k2y" + "partner":"4q3r" }, { "sim":51.0, - "partner":"5hxu" + "partner":"4q42" + }, + { + "sim":51.0, + "partner":"8k2y" }, { "sim":51.0, @@ -783766,6 +786857,10 @@ "sim":51.0, "partner":"5hwe" }, + { + "sim":51.0, + "partner":"5hxu" + }, { "sim":51.0, "partner":"3dkb" @@ -783862,10 +786957,6 @@ "sim":51.0, "partner":"4ggv" }, - { - "sim":51.0, - "partner":"5dvi" - }, { "sim":51.0, "partner":"5dvj" @@ -783876,15 +786967,15 @@ }, { "sim":51.0, - "partner":"5u22" + "partner":"5dvi" }, { "sim":51.0, - "partner":"2qgh" + "partner":"5u22" }, { "sim":51.0, - "partner":"5cu7" + "partner":"2qgh" }, { "sim":51.0, @@ -783906,6 +786997,10 @@ "sim":51.0, "partner":"5usr" }, + { + "sim":51.0, + "partner":"5cu7" + }, { "sim":51.0, "partner":"6hr7" @@ -783924,11 +787019,11 @@ }, { "sim":51.0, - "partner":"8xiz" + "partner":"2wio" }, { "sim":51.0, - "partner":"2wio" + "partner":"8xiz" }, { "sim":51.0, @@ -783938,10 +787033,6 @@ "sim":51.0, "partner":"3zdr" }, - { - "sim":51.0, - "partner":"4q6q" - }, { "sim":51.0, "partner":"7yp3" @@ -783974,6 +787065,10 @@ "sim":51.0, "partner":"4q6p" }, + { + "sim":51.0, + "partner":"4q6q" + }, { "sim":51.0, "partner":"6xcq" @@ -784002,10 +787097,6 @@ "sim":51.0, "partner":"3nmz" }, - { - "sim":51.0, - "partner":"5v1s" - }, { "sim":51.0, "partner":"5v1t" @@ -784016,15 +787107,15 @@ }, { "sim":51.0, - "partner":"2zfn" + "partner":"5v1s" }, { "sim":51.0, - "partner":"3rpu" + "partner":"2zfn" }, { "sim":51.0, - "partner":"4acg" + "partner":"3rpu" }, { "sim":51.0, @@ -784040,16 +787131,20 @@ }, { "sim":51.0, - "partner":"6jjo" + "partner":"4acg" }, { "sim":51.0, - "partner":"6ak4" + "partner":"6jjo" }, { "sim":51.0, "partner":"6aej" }, + { + "sim":51.0, + "partner":"6ak4" + }, { "sim":51.0, "partner":"6wiu" @@ -784070,10 +787165,6 @@ "sim":51.0, "partner":"6ewx" }, - { - "sim":51.0, - "partner":"6rk2" - }, { "sim":51.0, "partner":"6rjo" @@ -784088,11 +787179,11 @@ }, { "sim":51.0, - "partner":"4iei" + "partner":"6rjk" }, { "sim":51.0, - "partner":"6rjk" + "partner":"4iei" }, { "sim":51.0, @@ -784100,11 +787191,11 @@ }, { "sim":51.0, - "partner":"6akw" + "partner":"6rk2" }, { "sim":51.0, - "partner":"4ie7" + "partner":"6akw" }, { "sim":51.0, @@ -784124,15 +787215,15 @@ }, { "sim":51.0, - "partner":"4idz" + "partner":"7e8z" }, { "sim":51.0, - "partner":"4ie0" + "partner":"4idz" }, { "sim":51.0, - "partner":"7e8z" + "partner":"4ie0" }, { "sim":51.0, @@ -784150,6 +787241,10 @@ "sim":51.0, "partner":"4qho" }, + { + "sim":51.0, + "partner":"4ie7" + }, { "sim":51.0, "partner":"6rim" @@ -784206,10 +787301,6 @@ "sim":51.0, "partner":"7xkw" }, - { - "sim":51.0, - "partner":"5wm2" - }, { "sim":51.0, "partner":"5wm3" @@ -784230,6 +787321,10 @@ "sim":51.0, "partner":"5wm7" }, + { + "sim":51.0, + "partner":"5wm2" + }, { "sim":51.0, "partner":"6vgs" @@ -784240,11 +787335,11 @@ }, { "sim":51.0, - "partner":"5ess" + "partner":"5esd" }, { "sim":51.0, - "partner":"5esd" + "partner":"5ess" }, { "sim":51.0, @@ -784326,10 +787421,6 @@ "sim":51.0, "partner":"6k1g" }, - { - "sim":51.0, - "partner":"7rpw" - }, { "sim":51.0, "partner":"2hiv" @@ -784346,6 +787437,10 @@ "sim":51.0, "partner":"7rpo" }, + { + "sim":51.0, + "partner":"7rpw" + }, { "sim":51.0, "partner":"7kmm" @@ -784356,11 +787451,11 @@ }, { "sim":51.0, - "partner":"4gyk" + "partner":"4gyj" }, { "sim":51.0, - "partner":"4gyj" + "partner":"4gyk" }, { "sim":51.0, @@ -784384,16 +787479,12 @@ }, { "sim":51.0, - "partner":"5uw0" + "partner":"5uw1" }, { "sim":51.0, "partner":"5vnc" }, - { - "sim":51.0, - "partner":"5uw1" - }, { "sim":51.0, "partner":"4xpo" @@ -784424,11 +787515,11 @@ }, { "sim":51.0, - "partner":"4put" + "partner":"5uw0" }, { "sim":51.0, - "partner":"3rsz" + "partner":"4put" }, { "sim":51.0, @@ -784460,7 +787551,7 @@ }, { "sim":51.0, - "partner":"8wxf" + "partner":"3rsz" }, { "sim":51.0, @@ -784470,6 +787561,10 @@ "sim":51.0, "partner":"8wwp" }, + { + "sim":51.0, + "partner":"8wxf" + }, { "sim":51.0, "partner":"3slk" @@ -784510,10 +787605,6 @@ "sim":51.0, "partner":"7ufu" }, - { - "sim":51.0, - "partner":"6yt0" - }, { "sim":51.0, "partner":"4zhj" @@ -784530,6 +787621,10 @@ "sim":51.0, "partner":"6ytj" }, + { + "sim":51.0, + "partner":"6yt0" + }, { "sim":51.0, "partner":"2zxq" @@ -784640,15 +787735,15 @@ }, { "sim":50.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":50.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":50.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":50.0, @@ -784700,11 +787795,11 @@ }, { "sim":50.0, - "partner":"5x3t" + "partner":"6cky" }, { "sim":50.0, - "partner":"6cky" + "partner":"5x3t" }, { "sim":50.0, @@ -784790,18 +787885,10 @@ "sim":50.0, "partner":"5ako" }, - { - "sim":50.0, - "partner":"4gzc" - }, { "sim":50.0, "partner":"4gzd" }, - { - "sim":50.0, - "partner":"7t9o" - }, { "sim":50.0, "partner":"7u2u" @@ -784824,35 +787911,19 @@ }, { "sim":50.0, - "partner":"6e4e" - }, - { - "sim":50.0, - "partner":"4cec" - }, - { - "sim":50.0, - "partner":"4cgf" - }, - { - "sim":50.0, - "partner":"4chp" - }, - { - "sim":50.0, - "partner":"4cjt" + "partner":"4gzc" }, { "sim":50.0, - "partner":"3avi" + "partner":"7t9o" }, { "sim":50.0, - "partner":"4chq" + "partner":"6e4e" }, { "sim":50.0, - "partner":"4ovl" + "partner":"3av9" }, { "sim":50.0, @@ -784872,11 +787943,7 @@ }, { "sim":50.0, - "partner":"7ccl" - }, - { - "sim":50.0, - "partner":"3av9" + "partner":"7ccm" }, { "sim":50.0, @@ -784898,10 +787965,6 @@ "sim":50.0, "partner":"3avj" }, - { - "sim":50.0, - "partner":"7ccm" - }, { "sim":50.0, "partner":"4cef" @@ -785154,6 +788217,38 @@ "sim":50.0, "partner":"4cjs" }, + { + "sim":50.0, + "partner":"4chp" + }, + { + "sim":50.0, + "partner":"7ccl" + }, + { + "sim":50.0, + "partner":"4cec" + }, + { + "sim":50.0, + "partner":"4cgf" + }, + { + "sim":50.0, + "partner":"4cjt" + }, + { + "sim":50.0, + "partner":"3avi" + }, + { + "sim":50.0, + "partner":"4chq" + }, + { + "sim":50.0, + "partner":"4ovl" + }, { "sim":50.0, "partner":"8dpb" @@ -785164,11 +788259,11 @@ }, { "sim":50.0, - "partner":"1oqv" + "partner":"7l8l" }, { "sim":50.0, - "partner":"7l8l" + "partner":"1oqv" }, { "sim":50.0, @@ -785316,7 +788411,7 @@ }, { "sim":50.0, - "partner":"6ail" + "partner":"6ryk" }, { "sim":50.0, @@ -785324,15 +788419,15 @@ }, { "sim":50.0, - "partner":"6ryk" + "partner":"6ajp" }, { "sim":50.0, - "partner":"6ajp" + "partner":"6io9" }, { "sim":50.0, - "partner":"6io9" + "partner":"6ioa" }, { "sim":50.0, @@ -785340,7 +788435,7 @@ }, { "sim":50.0, - "partner":"6ioa" + "partner":"6ail" }, { "sim":50.0, @@ -785364,16 +788459,12 @@ }, { "sim":50.0, - "partner":"7o2t" + "partner":"6z17" }, { "sim":50.0, "partner":"7o2u" }, - { - "sim":50.0, - "partner":"6z17" - }, { "sim":50.0, "partner":"6yz3" @@ -785392,23 +788483,19 @@ }, { "sim":50.0, - "partner":"6kdr" - }, - { - "sim":50.0, - "partner":"6kds" + "partner":"7o2t" }, { "sim":50.0, - "partner":"4g7a" + "partner":"6kdr" }, { "sim":50.0, - "partner":"3ft5" + "partner":"6kds" }, { "sim":50.0, - "partner":"2xdx" + "partner":"4g7a" }, { "sim":50.0, @@ -785478,6 +788565,14 @@ "sim":50.0, "partner":"2xhx" }, + { + "sim":50.0, + "partner":"3ft5" + }, + { + "sim":50.0, + "partner":"2xdx" + }, { "sim":50.0, "partner":"4zb1" @@ -785492,11 +788587,11 @@ }, { "sim":50.0, - "partner":"6ey1" + "partner":"6f0w" }, { "sim":50.0, - "partner":"6f0w" + "partner":"6ey1" }, { "sim":50.0, @@ -785564,11 +788659,11 @@ }, { "sim":50.0, - "partner":"1z5z" + "partner":"1l2j" }, { "sim":50.0, - "partner":"1l2j" + "partner":"1z5z" }, { "sim":50.0, @@ -785594,10 +788689,6 @@ "sim":50.0, "partner":"5caj" }, - { - "sim":50.0, - "partner":"1zw3" - }, { "sim":50.0, "partner":"1zvz" @@ -785612,7 +788703,7 @@ }, { "sim":50.0, - "partner":"4fq7" + "partner":"1zw3" }, { "sim":50.0, @@ -785622,6 +788713,10 @@ "sim":50.0, "partner":"4fq5" }, + { + "sim":50.0, + "partner":"4fq7" + }, { "sim":50.0, "partner":"6jhu" @@ -785660,11 +788755,11 @@ }, { "sim":50.0, - "partner":"4rni" + "partner":"4rnj" }, { "sim":50.0, - "partner":"4rnj" + "partner":"4rni" }, { "sim":50.0, @@ -785676,15 +788771,15 @@ }, { "sim":50.0, - "partner":"2ovb" + "partner":"2ovf" }, { "sim":50.0, - "partner":"2ovf" + "partner":"2ov8" }, { "sim":50.0, - "partner":"2ov8" + "partner":"2ovb" }, { "sim":50.0, @@ -785706,10 +788801,6 @@ "sim":50.0, "partner":"8rhu" }, - { - "sim":50.0, - "partner":"7xrt" - }, { "sim":50.0, "partner":"7xrv" @@ -785720,7 +788811,7 @@ }, { "sim":50.0, - "partner":"6wye" + "partner":"7xrt" }, { "sim":50.0, @@ -785730,6 +788821,10 @@ "sim":50.0, "partner":"4ats" }, + { + "sim":50.0, + "partner":"6wye" + }, { "sim":50.0, "partner":"5nss" @@ -785754,10 +788849,6 @@ "sim":50.0, "partner":"4rw5" }, - { - "sim":50.0, - "partner":"4pgc" - }, { "sim":50.0, "partner":"4pgd" @@ -785774,6 +788865,10 @@ "sim":50.0, "partner":"4pgb" }, + { + "sim":50.0, + "partner":"4pgc" + }, { "sim":50.0, "partner":"7vmc" @@ -785810,10 +788905,6 @@ "sim":50.0, "partner":"1g93" }, - { - "sim":50.0, - "partner":"6y5x" - }, { "sim":50.0, "partner":"6y5y" @@ -785824,11 +788915,11 @@ }, { "sim":50.0, - "partner":"5a7y" + "partner":"6y5x" }, { "sim":50.0, - "partner":"5ybr" + "partner":"5a7y" }, { "sim":50.0, @@ -785858,6 +788949,10 @@ "sim":50.0, "partner":"5ybq" }, + { + "sim":50.0, + "partner":"5ybr" + }, { "sim":50.0, "partner":"1ynp" @@ -785894,14 +788989,6 @@ "sim":50.0, "partner":"5z75" }, - { - "sim":50.0, - "partner":"2nq6" - }, - { - "sim":50.0, - "partner":"2nq7" - }, { "sim":50.0, "partner":"2b3k" @@ -785946,6 +789033,14 @@ "sim":50.0, "partner":"3rlh" }, + { + "sim":50.0, + "partner":"2nq6" + }, + { + "sim":50.0, + "partner":"2nq7" + }, { "sim":50.0, "partner":"8iwl" @@ -786004,39 +789099,39 @@ }, { "sim":50.0, - "partner":"4ypv" + "partner":"6iid" }, { "sim":50.0, - "partner":"5zkj" + "partner":"8g5w" }, { "sim":50.0, - "partner":"6iid" + "partner":"7js3" }, { "sim":50.0, - "partner":"7js3" + "partner":"8g5x" }, { "sim":50.0, - "partner":"8g5w" + "partner":"7txa" }, { "sim":50.0, - "partner":"8g5x" + "partner":"7txg" }, { "sim":50.0, - "partner":"7txa" + "partner":"5zki" }, { "sim":50.0, - "partner":"5zki" + "partner":"4ypv" }, { "sim":50.0, - "partner":"7txg" + "partner":"5zkj" }, { "sim":50.0, @@ -786064,20 +789159,12 @@ }, { "sim":50.0, - "partner":"6pi5" + "partner":"6pi6" }, { "sim":50.0, "partner":"6pii" }, - { - "sim":50.0, - "partner":"7ajm" - }, - { - "sim":50.0, - "partner":"6pi6" - }, { "sim":50.0, "partner":"7a4r" @@ -786096,31 +789183,19 @@ }, { "sim":50.0, - "partner":"3ly2" - }, - { - "sim":50.0, - "partner":"5y3x" - }, - { - "sim":50.0, - "partner":"7a53" - }, - { - "sim":50.0, - "partner":"7ajw" + "partner":"6pi5" }, { "sim":50.0, - "partner":"7akb" + "partner":"7ajm" }, { "sim":50.0, - "partner":"7ajy" + "partner":"3ly2" }, { "sim":50.0, - "partner":"7a5l" + "partner":"5y3x" }, { "sim":50.0, @@ -786182,10 +789257,30 @@ "sim":50.0, "partner":"7aka" }, + { + "sim":50.0, + "partner":"7a53" + }, { "sim":50.0, "partner":"7akl" }, + { + "sim":50.0, + "partner":"7ajw" + }, + { + "sim":50.0, + "partner":"7akb" + }, + { + "sim":50.0, + "partner":"7ajy" + }, + { + "sim":50.0, + "partner":"7a5l" + }, { "sim":50.0, "partner":"7mgv" @@ -786226,17 +789321,13 @@ "sim":50.0, "partner":"3wce" }, - { - "sim":50.0, - "partner":"7f6d" - }, { "sim":50.0, "partner":"1si7" }, { "sim":50.0, - "partner":"8ixa" + "partner":"7f6d" }, { "sim":50.0, @@ -786252,11 +789343,11 @@ }, { "sim":50.0, - "partner":"6wug" + "partner":"8ixe" }, { "sim":50.0, - "partner":"8ixe" + "partner":"6wug" }, { "sim":50.0, @@ -786266,6 +789357,10 @@ "sim":50.0, "partner":"8ixg" }, + { + "sim":50.0, + "partner":"8ixa" + }, { "sim":50.0, "partner":"7qwt" @@ -786316,123 +789411,119 @@ }, { "sim":50.0, - "partner":"6x4k" - }, - { - "sim":50.0, - "partner":"7ue4" + "partner":"7ue8" }, { "sim":50.0, - "partner":"6x4l" + "partner":"7uep" }, { "sim":50.0, - "partner":"7ue5" + "partner":"7ueq" }, { "sim":50.0, - "partner":"5kpz" + "partner":"7uer" }, { "sim":50.0, - "partner":"6pe6" + "partner":"7ues" }, { "sim":50.0, - "partner":"7ue6" + "partner":"7uet" }, { "sim":50.0, - "partner":"7ue7" + "partner":"7ueu" }, { "sim":50.0, - "partner":"7ueo" + "partner":"7uev" }, { "sim":50.0, - "partner":"7ue8" + "partner":"7uex" }, { "sim":50.0, - "partner":"7uep" + "partner":"5kpt" }, { "sim":50.0, - "partner":"7ueq" + "partner":"7uey" }, { "sim":50.0, - "partner":"7uer" + "partner":"6b3v" }, { "sim":50.0, - "partner":"7ues" + "partner":"5kpr" }, { "sim":50.0, - "partner":"7uet" + "partner":"6wyo" }, { "sim":50.0, - "partner":"7ueu" + "partner":"6wyp" }, { "sim":50.0, - "partner":"7uev" + "partner":"6wyq" }, { "sim":50.0, - "partner":"5kpt" + "partner":"5kq8" }, { "sim":50.0, - "partner":"7uex" + "partner":"6x4j" }, { "sim":50.0, - "partner":"6b3v" + "partner":"5kqd" }, { "sim":50.0, - "partner":"7uey" + "partner":"6x4k" }, { "sim":50.0, - "partner":"5kpr" + "partner":"7ue3" }, { "sim":50.0, - "partner":"6wyo" + "partner":"6x4l" }, { "sim":50.0, - "partner":"6wyp" + "partner":"7ue4" }, { "sim":50.0, - "partner":"6wyq" + "partner":"6pe6" }, { "sim":50.0, - "partner":"5kq8" + "partner":"7ue5" }, { "sim":50.0, - "partner":"5kqd" + "partner":"7ue6" }, { "sim":50.0, - "partner":"6x4j" + "partner":"5kpz" }, { "sim":50.0, - "partner":"7ue3" + "partner":"7ue7" }, { "sim":50.0, - "partner":"3pz9" + "partner":"7ueo" }, { "sim":50.0, @@ -786460,7 +789551,7 @@ }, { "sim":50.0, - "partner":"2o0h" + "partner":"3pz9" }, { "sim":50.0, @@ -786472,23 +789563,11 @@ }, { "sim":50.0, - "partner":"8sm8" - }, - { - "sim":50.0, - "partner":"6kjh" - }, - { - "sim":50.0, - "partner":"6zgp" - }, - { - "sim":50.0, - "partner":"6y8j" + "partner":"2o0h" }, { "sim":50.0, - "partner":"6y9c" + "partner":"8sm8" }, { "sim":50.0, @@ -786496,7 +789575,7 @@ }, { "sim":50.0, - "partner":"6kjj" + "partner":"6zgp" }, { "sim":50.0, @@ -786518,6 +789597,22 @@ "sim":50.0, "partner":"6y8s" }, + { + "sim":50.0, + "partner":"6kjh" + }, + { + "sim":50.0, + "partner":"6y8j" + }, + { + "sim":50.0, + "partner":"6y9c" + }, + { + "sim":50.0, + "partner":"6kjj" + }, { "sim":50.0, "partner":"8iry" @@ -786542,10 +789637,6 @@ "sim":50.0, "partner":"2h4p" }, - { - "sim":50.0, - "partner":"1xm6" - }, { "sim":50.0, "partner":"1xos" @@ -786592,7 +789683,7 @@ }, { "sim":50.0, - "partner":"7sc6" + "partner":"1xm6" }, { "sim":50.0, @@ -786608,11 +789699,7 @@ }, { "sim":50.0, - "partner":"7c26" - }, - { - "sim":50.0, - "partner":"7c27" + "partner":"7sc6" }, { "sim":50.0, @@ -786646,6 +789733,14 @@ "sim":50.0, "partner":"7c25" }, + { + "sim":50.0, + "partner":"7c26" + }, + { + "sim":50.0, + "partner":"7c27" + }, { "sim":50.0, "partner":"5tuk" @@ -786670,10 +789765,6 @@ "sim":50.0, "partner":"7psu" }, - { - "sim":50.0, - "partner":"2gqn" - }, { "sim":50.0, "partner":"8spc" @@ -786688,7 +789779,7 @@ }, { "sim":50.0, - "partner":"4euh" + "partner":"2gqn" }, { "sim":50.0, @@ -786702,6 +789793,10 @@ "sim":50.0, "partner":"4euf" }, + { + "sim":50.0, + "partner":"4euh" + }, { "sim":50.0, "partner":"8d19" @@ -786724,11 +789819,11 @@ }, { "sim":50.0, - "partner":"8u2m" + "partner":"8ukz" }, { "sim":50.0, - "partner":"8ukz" + "partner":"8u2m" }, { "sim":50.0, @@ -786740,11 +789835,11 @@ }, { "sim":50.0, - "partner":"5d40" + "partner":"5d3u" }, { "sim":50.0, - "partner":"5d3u" + "partner":"5d40" }, { "sim":50.0, @@ -786760,31 +789855,31 @@ }, { "sim":50.0, - "partner":"6j87" + "partner":"6j85" }, { "sim":50.0, - "partner":"6j88" + "partner":"6j86" }, { "sim":50.0, - "partner":"6j85" + "partner":"6j87" }, { "sim":50.0, - "partner":"6j86" + "partner":"6j88" }, { "sim":50.0, - "partner":"5z8a" + "partner":"5z8k" }, { "sim":50.0, - "partner":"5z8k" + "partner":"5z83" }, { "sim":50.0, - "partner":"5z83" + "partner":"5z8a" }, { "sim":50.0, @@ -786868,15 +789963,15 @@ }, { "sim":50.0, - "partner":"2gps" + "partner":"2gpw" }, { "sim":50.0, - "partner":"6oi9" + "partner":"2gps" }, { "sim":50.0, - "partner":"2gpw" + "partner":"6oi9" }, { "sim":50.0, @@ -786928,15 +790023,15 @@ }, { "sim":50.0, - "partner":"4dqw" + "partner":"6gjv" }, { "sim":50.0, - "partner":"6gjv" + "partner":"6gk9" }, { "sim":50.0, - "partner":"6gk9" + "partner":"4dqw" }, { "sim":50.0, @@ -787128,15 +790223,15 @@ }, { "sim":50.0, - "partner":"6tsh" + "partner":"6tsk" }, { "sim":50.0, - "partner":"6tte" + "partner":"6tsh" }, { "sim":50.0, - "partner":"6tsk" + "partner":"6tte" }, { "sim":50.0, @@ -787247,90 +790342,90 @@ "8-helix anti-parallel alpha-helical barrel" ], "keywords":[ - "require", - "monomeric", - "channels", - "seeded", - "peptide", - "accelerating", - "including", - "pipelines", + "made", + "open", + "genes", + "defined", + "escherichia", + "minimizes", + "families", + "rapidly", + "short", + "protein", + "six", + "fully", + "novo", "throughout", - "parallel", + "match", + "motifs", + "pipelines", + "two", + "helices", + "adjacent", + "antiparallel", + "characterized", + "however", + "soluble", + "starting", + "define", + "residues", + "targets", + "connected", + "layer", + "bind", + "proteins", + "accelerating", + "process", + "accuracy", "outer", + "small", + "barrel", + "longer", + "computational", + "including", + "peptide", + "design", "sampling", - "sequences", - "expression", - "bind", - "synthetic", + "onto", + "express", "packed", - "escherichia", + "loops", + "maintained", + "oligomeric", + "namely", + "validated", + "connectors", + "coli", + "parallel", "building", - "however", - "starting", + "seeded", + "channels", + "states", + "sequence", + "peptides", + "describe", + "assemblies", + "advancing", + "central", "average", - "longer", - "connectors", - "proteins", "models", - "process", - "de", - "characterized", - "rapidly", + "sequences", + "require", "efficient", - "open", - "small", - "short", - "maintained", - "fully", - "made", - "match", - "onto", + "loop", "structures", + "de", + "70", + "synthetic", + "monomeric", "give", - "motifs", "molecules", - "layer", - "loops", - "connected", - "defined", - "families", - "assemblies", - "coli", - "70", - "namely", - "define", - "six", - "design", - "minimizes", - "express", - "soluble", - "states", "routes", - "describe", "high", - "sequence", - "genes", - "accuracy", - "designs", - "advancing", - "helices", - "barrels", - "novo", - "barrel", "sufficient", - "peptides", - "residues", - "adjacent", - "two", - "validated", - "antiparallel", - "central", - "protein", - "targets", - "computational", - "oligomeric", - "loop" + "expression", + "designs", + "barrels" ], "release_date":"2024-07-03", "publication":"\"Rationally seeded computational protein design of ɑ-helical barrels\", Nat.Chem.Biol., 20, 991-999", @@ -787363,11 +790458,11 @@ "seq_thr_sim_designed":[ { "sim":114.0, - "partner":"8qae" + "partner":"8qad" }, { "sim":114.0, - "partner":"8qad" + "partner":"8qae" }, { "sim":56.0, @@ -787391,11 +790486,11 @@ }, { "sim":52.0, - "partner":"8jpa" + "partner":"8hdv" }, { "sim":52.0, - "partner":"8hdv" + "partner":"8jpa" }, { "sim":51.0, @@ -787403,11 +790498,11 @@ }, { "sim":51.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":51.0, - "partner":"8w08" + "partner":"8v0a" }, { "sim":51.0, @@ -787473,15 +790568,15 @@ }, { "sim":59.0, - "partner":"5kdn" + "partner":"5kds" }, { "sim":59.0, - "partner":"5kds" + "partner":"5kdu" }, { "sim":59.0, - "partner":"5kdu" + "partner":"5kdn" }, { "sim":59.0, @@ -787521,23 +790616,23 @@ }, { "sim":58.0, - "partner":"6zgp" + "partner":"6y9d" }, { "sim":58.0, - "partner":"6y8j" + "partner":"6zgp" }, { "sim":58.0, - "partner":"6y9c" + "partner":"6y8s" }, { "sim":58.0, - "partner":"6y9d" + "partner":"6y8j" }, { "sim":58.0, - "partner":"6y8s" + "partner":"6y9c" }, { "sim":57.0, @@ -787583,10 +790678,6 @@ "sim":57.0, "partner":"5duf" }, - { - "sim":57.0, - "partner":"6o98" - }, { "sim":57.0, "partner":"7jh2" @@ -787599,6 +790690,10 @@ "sim":57.0, "partner":"6xfv" }, + { + "sim":57.0, + "partner":"6o98" + }, { "sim":57.0, "partner":"1xwj" @@ -787615,14 +790710,6 @@ "sim":57.0, "partner":"1u6h" }, - { - "sim":57.0, - "partner":"7kqj" - }, - { - "sim":57.0, - "partner":"6vqf" - }, { "sim":57.0, "partner":"7kxd" @@ -787667,6 +790754,14 @@ "sim":57.0, "partner":"7luk" }, + { + "sim":57.0, + "partner":"6vqf" + }, + { + "sim":57.0, + "partner":"7kqj" + }, { "sim":57.0, "partner":"5yc9" @@ -787717,31 +790812,31 @@ }, { "sim":57.0, - "partner":"7vzz" + "partner":"7vx0" }, { "sim":57.0, - "partner":"7vzu" + "partner":"7vzy" }, { "sim":57.0, - "partner":"7vx0" + "partner":"7vzz" }, { "sim":57.0, - "partner":"7vzy" + "partner":"7vzu" }, { "sim":57.0, - "partner":"8wxf" + "partner":"8wx0" }, { "sim":57.0, - "partner":"8wx0" + "partner":"8wwp" }, { "sim":57.0, - "partner":"8wwp" + "partner":"8wxf" }, { "sim":56.0, @@ -787833,27 +790928,27 @@ }, { "sim":55.0, - "partner":"6tlm" + "partner":"6tlt" }, { "sim":55.0, - "partner":"6tlq" + "partner":"6t4g" }, { "sim":55.0, - "partner":"6tlt" + "partner":"6t4i" }, { "sim":55.0, - "partner":"6t4g" + "partner":"6t4j" }, { "sim":55.0, - "partner":"6t4i" + "partner":"6t4k" }, { "sim":55.0, - "partner":"6t4j" + "partner":"6t4x" }, { "sim":55.0, @@ -787861,19 +790956,19 @@ }, { "sim":55.0, - "partner":"6t4k" + "partner":"6t4y" }, { "sim":55.0, - "partner":"6t4x" + "partner":"6t50" }, { "sim":55.0, - "partner":"6t4y" + "partner":"6tlm" }, { "sim":55.0, - "partner":"6t50" + "partner":"6tlq" }, { "sim":55.0, @@ -787939,14 +791034,6 @@ "sim":55.0, "partner":"5z75" }, - { - "sim":55.0, - "partner":"5tyq" - }, - { - "sim":55.0, - "partner":"5u19" - }, { "sim":55.0, "partner":"5u0n" @@ -787965,11 +791052,11 @@ }, { "sim":55.0, - "partner":"5gg5" + "partner":"5tyq" }, { "sim":55.0, - "partner":"5xd1" + "partner":"5u19" }, { "sim":55.0, @@ -787985,27 +791072,27 @@ }, { "sim":55.0, - "partner":"5gg7" + "partner":"6m6y" }, { "sim":55.0, - "partner":"5xd4" + "partner":"5gg7" }, { "sim":55.0, - "partner":"5xd5" + "partner":"5xd4" }, { "sim":55.0, - "partner":"6m6y" + "partner":"6m65" }, { "sim":55.0, - "partner":"5gg8" + "partner":"5xd5" }, { "sim":55.0, - "partner":"6m65" + "partner":"5gg8" }, { "sim":55.0, @@ -788035,6 +791122,14 @@ "sim":55.0, "partner":"6m69" }, + { + "sim":55.0, + "partner":"5gg5" + }, + { + "sim":55.0, + "partner":"5xd1" + }, { "sim":55.0, "partner":"4h3k" @@ -788105,11 +791200,11 @@ }, { "sim":54.0, - "partner":"7p4y" + "partner":"7p50" }, { "sim":54.0, - "partner":"7p50" + "partner":"7p4y" }, { "sim":54.0, @@ -788161,11 +791256,11 @@ }, { "sim":54.0, - "partner":"8jnr" + "partner":"2iuw" }, { "sim":54.0, - "partner":"2iuw" + "partner":"8jnr" }, { "sim":54.0, @@ -788179,10 +791274,6 @@ "sim":54.0, "partner":"7n8w" }, - { - "sim":54.0, - "partner":"1zw3" - }, { "sim":54.0, "partner":"1zvz" @@ -788197,12 +791288,16 @@ }, { "sim":54.0, - "partner":"6fcn" + "partner":"1zw3" }, { "sim":54.0, "partner":"6fcm" }, + { + "sim":54.0, + "partner":"6fcn" + }, { "sim":54.0, "partner":"5y7x" @@ -788273,11 +791368,11 @@ }, { "sim":54.0, - "partner":"7f79" + "partner":"7f77" }, { "sim":54.0, - "partner":"7f77" + "partner":"7f79" }, { "sim":54.0, @@ -788285,15 +791380,15 @@ }, { "sim":54.0, - "partner":"4dqw" + "partner":"6gjv" }, { "sim":54.0, - "partner":"6gjv" + "partner":"6gk9" }, { "sim":54.0, - "partner":"6gk9" + "partner":"4dqw" }, { "sim":54.0, @@ -788313,7 +791408,7 @@ }, { "sim":54.0, - "partner":"5m12" + "partner":"6gwg" }, { "sim":54.0, @@ -788321,31 +791416,31 @@ }, { "sim":54.0, - "partner":"6gwf" + "partner":"6gta" }, { "sim":54.0, - "partner":"6gwg" + "partner":"5m16" }, { "sim":54.0, - "partner":"5m16" + "partner":"6gvd" }, { "sim":54.0, - "partner":"6gta" + "partner":"5m0x" }, { "sim":54.0, - "partner":"6gvd" + "partner":"6gx8" }, { "sim":54.0, - "partner":"5m0x" + "partner":"5m12" }, { "sim":54.0, - "partner":"6gx8" + "partner":"6gwf" }, { "sim":54.0, @@ -788399,10 +791494,6 @@ "sim":53.0, "partner":"4azn" }, - { - "sim":53.0, - "partner":"5hso" - }, { "sim":53.0, "partner":"5x7z" @@ -788415,6 +791506,10 @@ "sim":53.0, "partner":"5hsm" }, + { + "sim":53.0, + "partner":"5hso" + }, { "sim":53.0, "partner":"6ecy" @@ -788447,10 +791542,6 @@ "sim":53.0, "partner":"2e1c" }, - { - "sim":53.0, - "partner":"1ri7" - }, { "sim":53.0, "partner":"7f0y" @@ -788461,11 +791552,11 @@ }, { "sim":53.0, - "partner":"7f10" + "partner":"1ri7" }, { "sim":53.0, - "partner":"2zny" + "partner":"7f10" }, { "sim":53.0, @@ -788475,6 +791566,10 @@ "sim":53.0, "partner":"7f11" }, + { + "sim":53.0, + "partner":"2zny" + }, { "sim":53.0, "partner":"8ar6" @@ -788509,15 +791604,11 @@ }, { "sim":53.0, - "partner":"6pj9" - }, - { - "sim":53.0, - "partner":"6pja" + "partner":"6pjp" }, { "sim":53.0, - "partner":"6pjp" + "partner":"6pjq" }, { "sim":53.0, @@ -788525,11 +791616,11 @@ }, { "sim":53.0, - "partner":"6pjq" + "partner":"6pjr" }, { "sim":53.0, - "partner":"6pjr" + "partner":"6pju" }, { "sim":53.0, @@ -788539,10 +791630,6 @@ "sim":53.0, "partner":"5f5d" }, - { - "sim":53.0, - "partner":"6pju" - }, { "sim":53.0, "partner":"4njp" @@ -788565,15 +791652,19 @@ }, { "sim":53.0, - "partner":"5f5j" + "partner":"6pj5" }, { "sim":53.0, - "partner":"6pj5" + "partner":"6pj7" }, { "sim":53.0, - "partner":"6pj7" + "partner":"5f5j" + }, + { + "sim":53.0, + "partner":"6pj8" }, { "sim":53.0, @@ -788581,20 +791672,24 @@ }, { "sim":53.0, - "partner":"6pj8" + "partner":"6pj9" }, { "sim":53.0, - "partner":"2kn6" + "partner":"6pja" }, { "sim":53.0, - "partner":"6z0x" + "partner":"2kn6" }, { "sim":53.0, "partner":"6z0y" }, + { + "sim":53.0, + "partner":"6z0x" + }, { "sim":53.0, "partner":"2fz4" @@ -788723,10 +791818,6 @@ "sim":53.0, "partner":"3u3j" }, - { - "sim":53.0, - "partner":"3u3r" - }, { "sim":53.0, "partner":"3u3k" @@ -788739,6 +791830,10 @@ "sim":53.0, "partner":"3u3o" }, + { + "sim":53.0, + "partner":"3u3r" + }, { "sim":53.0, "partner":"5c4k" @@ -788785,31 +791880,27 @@ }, { "sim":53.0, - "partner":"4mfj" - }, - { - "sim":53.0, - "partner":"4mfk" + "partner":"4mfl" }, { "sim":53.0, - "partner":"4mfl" + "partner":"4mfp" }, { "sim":53.0, - "partner":"6iix" + "partner":"4mfq" }, { "sim":53.0, - "partner":"4mfp" + "partner":"4mfj" }, { "sim":53.0, - "partner":"4mfq" + "partner":"6iix" }, { "sim":53.0, - "partner":"1t9s" + "partner":"4mfk" }, { "sim":53.0, @@ -788837,123 +791928,127 @@ }, { "sim":53.0, - "partner":"1xoq" + "partner":"1t9s" }, { "sim":53.0, - "partner":"6ind" + "partner":"1y2b" }, { "sim":53.0, - "partner":"8w4r" + "partner":"6imt" }, { "sim":53.0, - "partner":"1xor" + "partner":"1y2c" }, { "sim":53.0, - "partner":"3iak" + "partner":"8k4c" }, { "sim":53.0, - "partner":"6imr" + "partner":"6ink" }, { "sim":53.0, - "partner":"7cbj" + "partner":"1y2d" }, { "sim":53.0, - "partner":"1y2b" + "partner":"1y2e" }, { "sim":53.0, - "partner":"6im6" + "partner":"6inm" }, { "sim":53.0, - "partner":"6imt" + "partner":"6imb" }, { "sim":53.0, - "partner":"1y2c" + "partner":"7cbq" }, { "sim":53.0, - "partner":"1y2d" + "partner":"7ysx" }, { "sim":53.0, - "partner":"6ink" + "partner":"6imd" }, { "sim":53.0, - "partner":"1y2e" + "partner":"8w4q" }, { "sim":53.0, - "partner":"6inm" + "partner":"8w4r" }, { "sim":53.0, - "partner":"6imb" + "partner":"1y2k" }, { "sim":53.0, - "partner":"8k4h" + "partner":"6imi" }, { "sim":53.0, - "partner":"7ysx" + "partner":"6imo" }, { "sim":53.0, - "partner":"7cbq" + "partner":"6lrm" }, { "sim":53.0, - "partner":"8k4c" + "partner":"1xom" }, { "sim":53.0, - "partner":"6imd" + "partner":"1xon" }, { "sim":53.0, - "partner":"1y2k" + "partner":"3k4s" }, { "sim":53.0, - "partner":"1xom" + "partner":"7yqf" }, { "sim":53.0, - "partner":"6imi" + "partner":"6ind" }, { "sim":53.0, - "partner":"6imo" + "partner":"1xoq" }, { "sim":53.0, - "partner":"6lrm" + "partner":"7cbj" }, { "sim":53.0, - "partner":"1xon" + "partner":"6imr" }, { "sim":53.0, - "partner":"3k4s" + "partner":"1xor" }, { "sim":53.0, - "partner":"7yqf" + "partner":"6im6" }, { "sim":53.0, - "partner":"8w4q" + "partner":"8k4h" + }, + { + "sim":53.0, + "partner":"3iak" }, { "sim":53.0, @@ -789013,11 +792108,11 @@ }, { "sim":53.0, - "partner":"8u2m" + "partner":"8ukz" }, { "sim":53.0, - "partner":"8ukz" + "partner":"8u2m" }, { "sim":53.0, @@ -789095,10 +792190,6 @@ "sim":53.0, "partner":"8ufj" }, - { - "sim":53.0, - "partner":"6oi8" - }, { "sim":53.0, "partner":"4mv1" @@ -789155,6 +792246,10 @@ "sim":53.0, "partner":"6ojh" }, + { + "sim":53.0, + "partner":"6oi8" + }, { "sim":53.0, "partner":"3tai" @@ -789215,14 +792310,6 @@ "sim":53.0, "partner":"7vpd" }, - { - "sim":53.0, - "partner":"4ids" - }, - { - "sim":53.0, - "partner":"4jdc" - }, { "sim":53.0, "partner":"4lem" @@ -789241,7 +792328,11 @@ }, { "sim":53.0, - "partner":"2q5l" + "partner":"4ids" + }, + { + "sim":53.0, + "partner":"4jdc" }, { "sim":53.0, @@ -789259,6 +792350,10 @@ "sim":53.0, "partner":"2q5j" }, + { + "sim":53.0, + "partner":"2q5l" + }, { "sim":53.0, "partner":"5ahk" @@ -789279,10 +792374,6 @@ "sim":53.0, "partner":"7vz3" }, - { - "sim":53.0, - "partner":"6yt0" - }, { "sim":53.0, "partner":"4zhj" @@ -789299,6 +792390,10 @@ "sim":53.0, "partner":"6ytj" }, + { + "sim":53.0, + "partner":"6yt0" + }, { "sim":52.0, "partner":"8ske" @@ -789381,15 +792476,15 @@ }, { "sim":52.0, - "partner":"4evd" + "partner":"4yif" }, { "sim":52.0, - "partner":"4eve" + "partner":"4evd" }, { "sim":52.0, - "partner":"4yif" + "partner":"4eve" }, { "sim":52.0, @@ -789487,10 +792582,6 @@ "sim":52.0, "partner":"6w6b" }, - { - "sim":52.0, - "partner":"3la7" - }, { "sim":52.0, "partner":"3la2" @@ -789503,6 +792594,10 @@ "sim":52.0, "partner":"3qc1" }, + { + "sim":52.0, + "partner":"3la7" + }, { "sim":52.0, "partner":"2brx" @@ -789523,10 +792618,6 @@ "sim":52.0, "partner":"3kmr" }, - { - "sim":52.0, - "partner":"4jyi" - }, { "sim":52.0, "partner":"4dm6" @@ -789565,16 +792656,20 @@ }, { "sim":52.0, - "partner":"6jox" + "partner":"4jyi" }, { "sim":52.0, - "partner":"2wk1" + "partner":"6jox" }, { "sim":52.0, "partner":"6ypa" }, + { + "sim":52.0, + "partner":"2wk1" + }, { "sim":52.0, "partner":"2rhq" @@ -789611,10 +792706,6 @@ "sim":52.0, "partner":"6joq" }, - { - "sim":52.0, - "partner":"3aio" - }, { "sim":52.0, "partner":"3aik" @@ -789635,6 +792726,10 @@ "sim":52.0, "partner":"3ain" }, + { + "sim":52.0, + "partner":"3aio" + }, { "sim":52.0, "partner":"5fd4" @@ -789691,10 +792786,6 @@ "sim":52.0, "partner":"8afu" }, - { - "sim":52.0, - "partner":"4d2w" - }, { "sim":52.0, "partner":"4d2p" @@ -789727,6 +792818,10 @@ "sim":52.0, "partner":"4d2v" }, + { + "sim":52.0, + "partner":"4d2w" + }, { "sim":52.0, "partner":"3obw" @@ -789755,10 +792850,6 @@ "sim":52.0, "partner":"5ve3" }, - { - "sim":52.0, - "partner":"3c1y" - }, { "sim":52.0, "partner":"3c1z" @@ -789803,6 +792894,10 @@ "sim":52.0, "partner":"5f8f" }, + { + "sim":52.0, + "partner":"3c1y" + }, { "sim":52.0, "partner":"8skn" @@ -789843,10 +792938,6 @@ "sim":52.0, "partner":"3sso" }, - { - "sim":52.0, - "partner":"4q6q" - }, { "sim":52.0, "partner":"4q6m" @@ -789865,11 +792956,11 @@ }, { "sim":52.0, - "partner":"4kp2" + "partner":"4q6q" }, { "sim":52.0, - "partner":"2r98" + "partner":"4kp2" }, { "sim":52.0, @@ -789893,7 +792984,7 @@ }, { "sim":52.0, - "partner":"5v1s" + "partner":"2r98" }, { "sim":52.0, @@ -789903,6 +792994,10 @@ "sim":52.0, "partner":"5v1q" }, + { + "sim":52.0, + "partner":"5v1s" + }, { "sim":52.0, "partner":"2hp0" @@ -789913,15 +793008,15 @@ }, { "sim":52.0, - "partner":"2gps" + "partner":"2gpw" }, { "sim":52.0, - "partner":"6oi9" + "partner":"2gps" }, { "sim":52.0, - "partner":"2gpw" + "partner":"6oi9" }, { "sim":52.0, @@ -789955,10 +793050,6 @@ "sim":52.0, "partner":"7zah" }, - { - "sim":52.0, - "partner":"7rpw" - }, { "sim":52.0, "partner":"2hiv" @@ -789975,6 +793066,10 @@ "sim":52.0, "partner":"7rpo" }, + { + "sim":52.0, + "partner":"7rpw" + }, { "sim":52.0, "partner":"2ix0" @@ -790179,10 +793274,6 @@ "sim":51.0, "partner":"1oy7" }, - { - "sim":51.0, - "partner":"3qna" - }, { "sim":51.0, "partner":"8gdy" @@ -790199,6 +793290,10 @@ "sim":51.0, "partner":"3qn9" }, + { + "sim":51.0, + "partner":"3qna" + }, { "sim":51.0, "partner":"4nss" @@ -790229,15 +793324,15 @@ }, { "sim":51.0, - "partner":"1vb6" + "partner":"1v9y" }, { "sim":51.0, - "partner":"1v9y" + "partner":"1v9z" }, { "sim":51.0, - "partner":"1v9z" + "partner":"1vb6" }, { "sim":51.0, @@ -790289,15 +793384,15 @@ }, { "sim":51.0, - "partner":"3kh9" + "partner":"7vmo" }, { "sim":51.0, - "partner":"7vmo" + "partner":"7vms" }, { "sim":51.0, - "partner":"7vms" + "partner":"3kh9" }, { "sim":51.0, @@ -790321,11 +793416,11 @@ }, { "sim":51.0, - "partner":"6uv7" + "partner":"6uvi" }, { "sim":51.0, - "partner":"6uvi" + "partner":"6uv7" }, { "sim":51.0, @@ -790389,15 +793484,15 @@ }, { "sim":51.0, - "partner":"3th5" + "partner":"4gzl" }, { "sim":51.0, - "partner":"4gzl" + "partner":"4gzm" }, { "sim":51.0, - "partner":"4gzm" + "partner":"3th5" }, { "sim":51.0, @@ -790469,23 +793564,23 @@ }, { "sim":51.0, - "partner":"4njh" + "partner":"4njj" }, { "sim":51.0, - "partner":"4nji" + "partner":"4njk" }, { "sim":51.0, - "partner":"4njj" + "partner":"4njg" }, { "sim":51.0, - "partner":"4njk" + "partner":"4njh" }, { "sim":51.0, - "partner":"4njg" + "partner":"4nji" }, { "sim":51.0, @@ -790571,10 +793666,6 @@ "sim":51.0, "partner":"3vwu" }, - { - "sim":51.0, - "partner":"4be6" - }, { "sim":51.0, "partner":"6azq" @@ -790607,6 +793698,10 @@ "sim":51.0, "partner":"4be5" }, + { + "sim":51.0, + "partner":"4be6" + }, { "sim":51.0, "partner":"2ouk" @@ -790631,14 +793726,6 @@ "sim":51.0, "partner":"4m7t" }, - { - "sim":51.0, - "partner":"5ds3" - }, - { - "sim":51.0, - "partner":"6bhv" - }, { "sim":51.0, "partner":"6ntu" @@ -790653,11 +793740,11 @@ }, { "sim":51.0, - "partner":"6nrf" + "partner":"8fyz" }, { "sim":51.0, - "partner":"8fyz" + "partner":"6nrf" }, { "sim":51.0, @@ -790675,6 +793762,14 @@ "sim":51.0, "partner":"6nrj" }, + { + "sim":51.0, + "partner":"6bhv" + }, + { + "sim":51.0, + "partner":"5ds3" + }, { "sim":51.0, "partner":"5d6t" @@ -790757,24 +793852,12 @@ }, { "sim":51.0, - "partner":"5coq" - }, - { - "sim":51.0, - "partner":"5cpb" - }, - { - "sim":51.0, - "partner":"5mtr" + "partner":"4oxk" }, { "sim":51.0, "partner":"5ugt" }, - { - "sim":51.0, - "partner":"4oxk" - }, { "sim":51.0, "partner":"5ugu" @@ -790785,15 +793868,15 @@ }, { "sim":51.0, - "partner":"4oxn" + "partner":"6yuu" }, { "sim":51.0, - "partner":"4oyr" + "partner":"4oxn" }, { "sim":51.0, - "partner":"6yuu" + "partner":"4oyr" }, { "sim":51.0, @@ -790819,10 +793902,22 @@ "sim":51.0, "partner":"5cp8" }, + { + "sim":51.0, + "partner":"5mtr" + }, { "sim":51.0, "partner":"5ugs" }, + { + "sim":51.0, + "partner":"5cpb" + }, + { + "sim":51.0, + "partner":"5coq" + }, { "sim":51.0, "partner":"6loi" @@ -790863,10 +793958,6 @@ "sim":51.0, "partner":"4biz" }, - { - "sim":51.0, - "partner":"5zm4" - }, { "sim":51.0, "partner":"5zm2" @@ -790877,7 +793968,7 @@ }, { "sim":51.0, - "partner":"3ggo" + "partner":"5zm4" }, { "sim":51.0, @@ -790895,6 +793986,10 @@ "sim":51.0, "partner":"3ggg" }, + { + "sim":51.0, + "partner":"3ggo" + }, { "sim":51.0, "partner":"6oid" @@ -790957,11 +794052,11 @@ }, { "sim":51.0, - "partner":"3auz" + "partner":"7lh6" }, { "sim":51.0, - "partner":"7lh6" + "partner":"3auz" }, { "sim":51.0, @@ -791027,10 +794122,6 @@ "sim":51.0, "partner":"6hm2" }, - { - "sim":51.0, - "partner":"6cwo" - }, { "sim":51.0, "partner":"4de7" @@ -791053,7 +794144,7 @@ }, { "sim":51.0, - "partner":"6vwr" + "partner":"6cwo" }, { "sim":51.0, @@ -791073,60 +794164,64 @@ }, { "sim":51.0, - "partner":"3sie" + "partner":"6vwr" }, { "sim":51.0, - "partner":"4g2w" + "partner":"4i9z" }, { "sim":51.0, - "partner":"8w4s" + "partner":"4ia0" }, { "sim":51.0, - "partner":"4g2y" + "partner":"4oew" }, { "sim":51.0, - "partner":"8w4t" + "partner":"4oex" }, { "sim":51.0, - "partner":"4i9z" + "partner":"6iwi" }, { "sim":51.0, - "partner":"4ia0" + "partner":"8w4s" }, { "sim":51.0, - "partner":"4oew" + "partner":"8w4t" }, { "sim":51.0, - "partner":"4oex" + "partner":"3shy" }, { "sim":51.0, - "partner":"6iwi" + "partner":"3shz" }, { "sim":51.0, - "partner":"3shy" + "partner":"3sie" }, { "sim":51.0, - "partner":"3shz" + "partner":"4g2w" }, { "sim":51.0, - "partner":"6sf5" + "partner":"4g2y" }, { "sim":51.0, "partner":"6sf4" }, + { + "sim":51.0, + "partner":"6sf5" + }, { "sim":51.0, "partner":"4dr0" @@ -791149,23 +794244,23 @@ }, { "sim":51.0, - "partner":"1x19" + "partner":"1x1b" }, { "sim":51.0, - "partner":"1x1a" + "partner":"1x1c" }, { "sim":51.0, - "partner":"1x1b" + "partner":"1x1d" }, { "sim":51.0, - "partner":"1x1c" + "partner":"1x19" }, { "sim":51.0, - "partner":"1x1d" + "partner":"1x1a" }, { "sim":51.0, @@ -791173,15 +794268,15 @@ }, { "sim":51.0, - "partner":"8uas" + "partner":"7us5" }, { "sim":51.0, - "partner":"7us5" + "partner":"8uar" }, { "sim":51.0, - "partner":"8uar" + "partner":"8uas" }, { "sim":51.0, @@ -791207,10 +794302,6 @@ "sim":51.0, "partner":"5xnh" }, - { - "sim":51.0, - "partner":"8ixa" - }, { "sim":51.0, "partner":"8ixd" @@ -791231,6 +794322,10 @@ "sim":51.0, "partner":"8ixg" }, + { + "sim":51.0, + "partner":"8ixa" + }, { "sim":51.0, "partner":"2yrf" @@ -791249,15 +794344,15 @@ }, { "sim":51.0, - "partner":"7y0k" + "partner":"7xwu" }, { "sim":51.0, - "partner":"7xwu" + "partner":"8h61" }, { "sim":51.0, - "partner":"8h61" + "partner":"7y0k" }, { "sim":51.0, @@ -791307,10 +794402,6 @@ "sim":51.0, "partner":"3exf" }, - { - "sim":51.0, - "partner":"6put" - }, { "sim":51.0, "partner":"7s47" @@ -791327,21 +794418,17 @@ "sim":51.0, "partner":"6v3k" }, - { - "sim":51.0, - "partner":"5u1c" - }, { "sim":51.0, "partner":"6puz" }, { "sim":51.0, - "partner":"4q3r" + "partner":"5u1c" }, { "sim":51.0, - "partner":"4q42" + "partner":"6put" }, { "sim":51.0, @@ -791375,6 +794462,14 @@ "sim":51.0, "partner":"4q41" }, + { + "sim":51.0, + "partner":"4q3r" + }, + { + "sim":51.0, + "partner":"4q42" + }, { "sim":51.0, "partner":"3av0" @@ -791433,15 +794528,15 @@ }, { "sim":51.0, - "partner":"6s0g" + "partner":"7bn6" }, { "sim":51.0, - "partner":"7bn6" + "partner":"6s23" }, { "sim":51.0, - "partner":"6s23" + "partner":"6s0g" }, { "sim":51.0, @@ -791485,35 +794580,35 @@ }, { "sim":51.0, - "partner":"2y46" + "partner":"3zsn" }, { "sim":51.0, - "partner":"2y5n" + "partner":"2y98" }, { "sim":51.0, - "partner":"2yca" + "partner":"2y5z" }, { "sim":51.0, - "partner":"3zsn" + "partner":"4aw3" }, { "sim":51.0, - "partner":"2y98" + "partner":"2ygx" }, { "sim":51.0, - "partner":"2y5z" + "partner":"2y46" }, { "sim":51.0, - "partner":"4aw3" + "partner":"2y5n" }, { "sim":51.0, - "partner":"2ygx" + "partner":"2yca" }, { "sim":51.0, @@ -791523,10 +794618,6 @@ "sim":51.0, "partner":"3l5a" }, - { - "sim":51.0, - "partner":"6e9b" - }, { "sim":51.0, "partner":"6e57" @@ -791541,7 +794632,7 @@ }, { "sim":51.0, - "partner":"5d40" + "partner":"6e9b" }, { "sim":51.0, @@ -791555,6 +794646,10 @@ "sim":51.0, "partner":"5d3u" }, + { + "sim":51.0, + "partner":"5d40" + }, { "sim":51.0, "partner":"4luq" @@ -791641,11 +794736,11 @@ }, { "sim":51.0, - "partner":"8il0" + "partner":"8ila" }, { "sim":51.0, - "partner":"8ila" + "partner":"8il0" }, { "sim":51.0, @@ -791657,11 +794752,11 @@ }, { "sim":51.0, - "partner":"3upu" + "partner":"8gme" }, { "sim":51.0, - "partner":"8gme" + "partner":"3upu" }, { "sim":51.0, @@ -791739,10 +794834,6 @@ "sim":51.0, "partner":"8hcz" }, - { - "sim":51.0, - "partner":"6rk2" - }, { "sim":51.0, "partner":"6rjo" @@ -791757,11 +794848,11 @@ }, { "sim":51.0, - "partner":"4iei" + "partner":"6rjk" }, { "sim":51.0, - "partner":"6rjk" + "partner":"4iei" }, { "sim":51.0, @@ -791769,7 +794860,7 @@ }, { "sim":51.0, - "partner":"6x0h" + "partner":"6rk2" }, { "sim":51.0, @@ -791781,15 +794872,15 @@ }, { "sim":51.0, - "partner":"7x4r" + "partner":"6x0h" }, { "sim":51.0, - "partner":"7x52" + "partner":"7x4r" }, { "sim":51.0, - "partner":"6qu3" + "partner":"7x52" }, { "sim":51.0, @@ -791803,6 +794894,10 @@ "sim":51.0, "partner":"7oz9" }, + { + "sim":51.0, + "partner":"6qu3" + }, { "sim":51.0, "partner":"6s21" @@ -791823,10 +794918,6 @@ "sim":51.0, "partner":"3qp9" }, - { - "sim":51.0, - "partner":"6crm" - }, { "sim":51.0, "partner":"6d23" @@ -791841,31 +794932,31 @@ }, { "sim":51.0, - "partner":"8gf0" + "partner":"6crm" }, { "sim":51.0, - "partner":"8gfp" + "partner":"6gnf" }, { "sim":51.0, - "partner":"8gf1" + "partner":"7lam" }, { "sim":51.0, - "partner":"8gfq" + "partner":"8gfb" }, { "sim":51.0, - "partner":"6gnf" + "partner":"8gfc" }, { "sim":51.0, - "partner":"8gfs" + "partner":"8gfd" }, { "sim":51.0, - "partner":"7lam" + "partner":"8gfe" }, { "sim":51.0, @@ -791873,63 +794964,63 @@ }, { "sim":51.0, - "partner":"8gfb" + "partner":"8gff" }, { "sim":51.0, - "partner":"8gfc" + "partner":"8gfg" }, { "sim":51.0, - "partner":"8gfd" + "partner":"8gfh" }, { "sim":51.0, - "partner":"8gfe" + "partner":"8gfi" }, { "sim":51.0, - "partner":"8gff" + "partner":"8gfj" }, { "sim":51.0, - "partner":"8gfg" + "partner":"8gfl" }, { "sim":51.0, - "partner":"8gfh" + "partner":"8gfm" }, { "sim":51.0, - "partner":"8gfi" + "partner":"8gez" }, { "sim":51.0, - "partner":"8gfj" + "partner":"8gf0" }, { "sim":51.0, - "partner":"8gfl" + "partner":"8gfp" }, { "sim":51.0, - "partner":"8gfm" + "partner":"8gf1" }, { "sim":51.0, - "partner":"8gez" + "partner":"8gfq" }, { "sim":51.0, - "partner":"6a50" + "partner":"8gfs" }, { "sim":51.0, - "partner":"2v6e" + "partner":"6a50" }, { "sim":51.0, - "partner":"5wm2" + "partner":"2v6e" }, { "sim":51.0, @@ -791951,6 +795042,10 @@ "sim":51.0, "partner":"5wm7" }, + { + "sim":51.0, + "partner":"5wm2" + }, { "sim":51.0, "partner":"3bdl" @@ -791967,10 +795062,6 @@ "sim":51.0, "partner":"4imp" }, - { - "sim":51.0, - "partner":"5tsh" - }, { "sim":51.0, "partner":"6olj" @@ -791981,19 +795072,19 @@ }, { "sim":51.0, - "partner":"8hdf" + "partner":"5tsh" }, { "sim":51.0, - "partner":"8iqu" + "partner":"8hd4" }, { "sim":51.0, - "partner":"8hd4" + "partner":"8hdf" }, { "sim":51.0, - "partner":"7tgl" + "partner":"8iqu" }, { "sim":51.0, @@ -792015,6 +795106,10 @@ "sim":51.0, "partner":"7tgk" }, + { + "sim":51.0, + "partner":"7tgl" + }, { "sim":51.0, "partner":"1oz0" @@ -792075,10 +795170,6 @@ "sim":51.0, "partner":"3vsn" }, - { - "sim":51.0, - "partner":"5lj7" - }, { "sim":51.0, "partner":"5lil" @@ -792089,7 +795180,7 @@ }, { "sim":51.0, - "partner":"7w1c" + "partner":"5lj7" }, { "sim":51.0, @@ -792103,6 +795194,10 @@ "sim":51.0, "partner":"7w1e" }, + { + "sim":51.0, + "partner":"7w1c" + }, { "sim":51.0, "partner":"5js4" @@ -792153,15 +795248,15 @@ }, { "sim":51.0, - "partner":"6tsh" + "partner":"6tsk" }, { "sim":51.0, - "partner":"6tte" + "partner":"6tsh" }, { "sim":51.0, - "partner":"6tsk" + "partner":"6tte" }, { "sim":51.0, @@ -792261,11 +795356,11 @@ }, { "sim":50.0, - "partner":"4hmr" + "partner":"3va1" }, { "sim":50.0, - "partner":"3va1" + "partner":"6t3o" }, { "sim":50.0, @@ -792273,15 +795368,15 @@ }, { "sim":50.0, - "partner":"6t3o" + "partner":"4hls" }, { "sim":50.0, - "partner":"4hls" + "partner":"4hmm" }, { "sim":50.0, - "partner":"4hmm" + "partner":"4hmr" }, { "sim":50.0, @@ -792323,10 +795418,6 @@ "sim":50.0, "partner":"6omx" }, - { - "sim":50.0, - "partner":"7eva" - }, { "sim":50.0, "partner":"6rgn" @@ -792337,11 +795428,11 @@ }, { "sim":50.0, - "partner":"3d7j" + "partner":"7eva" }, { "sim":50.0, - "partner":"3n39" + "partner":"3d7j" }, { "sim":50.0, @@ -792361,7 +795452,7 @@ }, { "sim":50.0, - "partner":"3rg6" + "partner":"3n39" }, { "sim":50.0, @@ -792369,11 +795460,11 @@ }, { "sim":50.0, - "partner":"5x3t" + "partner":"6cky" }, { "sim":50.0, - "partner":"6cky" + "partner":"5x3t" }, { "sim":50.0, @@ -792383,6 +795474,10 @@ "sim":50.0, "partner":"2peo" }, + { + "sim":50.0, + "partner":"3rg6" + }, { "sim":50.0, "partner":"2a4d" @@ -792399,10 +795494,6 @@ "sim":50.0, "partner":"6okn" }, - { - "sim":50.0, - "partner":"4evc" - }, { "sim":50.0, "partner":"3ta8" @@ -792417,11 +795508,7 @@ }, { "sim":50.0, - "partner":"2o4d" - }, - { - "sim":50.0, - "partner":"2vbq" + "partner":"4evc" }, { "sim":50.0, @@ -792435,6 +795522,14 @@ "sim":50.0, "partner":"1s60" }, + { + "sim":50.0, + "partner":"2o4d" + }, + { + "sim":50.0, + "partner":"2vbq" + }, { "sim":50.0, "partner":"2mux" @@ -792471,14 +795566,6 @@ "sim":50.0, "partner":"4hr7" }, - { - "sim":50.0, - "partner":"5scp" - }, - { - "sim":50.0, - "partner":"5scq" - }, { "sim":50.0, "partner":"5scr" @@ -792583,6 +795670,14 @@ "sim":50.0, "partner":"5sco" }, + { + "sim":50.0, + "partner":"5scp" + }, + { + "sim":50.0, + "partner":"5scq" + }, { "sim":50.0, "partner":"7ckv" @@ -792669,19 +795764,19 @@ }, { "sim":50.0, - "partner":"6f3z" + "partner":"6fhm" }, { "sim":50.0, - "partner":"6fhm" + "partner":"6f3z" }, { "sim":50.0, - "partner":"8xon" + "partner":"8xoo" }, { "sim":50.0, - "partner":"8xoo" + "partner":"8xon" }, { "sim":50.0, @@ -792693,19 +795788,19 @@ }, { "sim":50.0, - "partner":"5n7o" + "partner":"6hry" }, { "sim":50.0, - "partner":"6hry" + "partner":"5n7o" }, { "sim":50.0, - "partner":"5n1c" + "partner":"6hrz" }, { "sim":50.0, - "partner":"6hrz" + "partner":"5n1c" }, { "sim":50.0, @@ -792829,19 +795924,19 @@ }, { "sim":50.0, - "partner":"4bmx" + "partner":"4bmz" }, { "sim":50.0, - "partner":"4bmy" + "partner":"4bn0" }, { "sim":50.0, - "partner":"4bmz" + "partner":"4bmx" }, { "sim":50.0, - "partner":"4bn0" + "partner":"4bmy" }, { "sim":50.0, @@ -792853,15 +795948,15 @@ }, { "sim":50.0, - "partner":"7d9v" + "partner":"7d8h" }, { "sim":50.0, - "partner":"7d8p" + "partner":"7d9v" }, { "sim":50.0, - "partner":"7d8h" + "partner":"7d8p" }, { "sim":50.0, @@ -792897,11 +795992,11 @@ }, { "sim":50.0, - "partner":"6hxo" + "partner":"6hxn" }, { "sim":50.0, - "partner":"6hxn" + "partner":"6hxo" }, { "sim":50.0, @@ -792935,14 +796030,6 @@ "sim":50.0, "partner":"5gwx" }, - { - "sim":50.0, - "partner":"4rni" - }, - { - "sim":50.0, - "partner":"8u0n" - }, { "sim":50.0, "partner":"4rnj" @@ -792961,11 +796048,15 @@ }, { "sim":50.0, - "partner":"6mni" + "partner":"8u0n" }, { "sim":50.0, - "partner":"2ovb" + "partner":"4rni" + }, + { + "sim":50.0, + "partner":"6mni" }, { "sim":50.0, @@ -792999,6 +796090,10 @@ "sim":50.0, "partner":"5djk" }, + { + "sim":50.0, + "partner":"2ovb" + }, { "sim":50.0, "partner":"8rhv" @@ -793021,19 +796116,19 @@ }, { "sim":50.0, - "partner":"7a61" + "partner":"8rwq" }, { "sim":50.0, - "partner":"5uj3" + "partner":"6mnp" }, { "sim":50.0, - "partner":"5uj4" + "partner":"8rwr" }, { "sim":50.0, - "partner":"6mnp" + "partner":"5uj3" }, { "sim":50.0, @@ -793041,11 +796136,11 @@ }, { "sim":50.0, - "partner":"5h1w" + "partner":"8rws" }, { "sim":50.0, - "partner":"5ul8" + "partner":"5uj4" }, { "sim":50.0, @@ -793059,6 +796154,14 @@ "sim":50.0, "partner":"6d17" }, + { + "sim":50.0, + "partner":"5h1w" + }, + { + "sim":50.0, + "partner":"5ul8" + }, { "sim":50.0, "partner":"6d18" @@ -793099,10 +796202,6 @@ "sim":50.0, "partner":"6z24" }, - { - "sim":50.0, - "partner":"5b7y" - }, { "sim":50.0, "partner":"6qwd" @@ -793115,13 +796214,17 @@ "sim":50.0, "partner":"6qwe" }, + { + "sim":50.0, + "partner":"5b7y" + }, { "sim":50.0, "partner":"5b7z" }, { "sim":50.0, - "partner":"8rwq" + "partner":"6mey" }, { "sim":50.0, @@ -793129,15 +796232,15 @@ }, { "sim":50.0, - "partner":"6mey" + "partner":"6v1j" }, { "sim":50.0, - "partner":"5h6h" + "partner":"8aki" }, { "sim":50.0, - "partner":"6v1j" + "partner":"5h6h" }, { "sim":50.0, @@ -793145,7 +796248,7 @@ }, { "sim":50.0, - "partner":"8aki" + "partner":"8akj" }, { "sim":50.0, @@ -793157,7 +796260,7 @@ }, { "sim":50.0, - "partner":"8akj" + "partner":"8akk" }, { "sim":50.0, @@ -793165,7 +796268,11 @@ }, { "sim":50.0, - "partner":"8akk" + "partner":"8akl" + }, + { + "sim":50.0, + "partner":"8akm" }, { "sim":50.0, @@ -793173,15 +796280,15 @@ }, { "sim":50.0, - "partner":"8akl" + "partner":"7a61" }, { "sim":50.0, - "partner":"8akm" + "partner":"8rwo" }, { "sim":50.0, - "partner":"7xrt" + "partner":"8rwp" }, { "sim":50.0, @@ -793193,7 +796300,7 @@ }, { "sim":50.0, - "partner":"6wye" + "partner":"7xrt" }, { "sim":50.0, @@ -793207,6 +796314,10 @@ "sim":50.0, "partner":"4ats" }, + { + "sim":50.0, + "partner":"6wye" + }, { "sim":50.0, "partner":"4cf6" @@ -793251,10 +796362,6 @@ "sim":50.0, "partner":"4rw5" }, - { - "sim":50.0, - "partner":"4pgc" - }, { "sim":50.0, "partner":"4pgd" @@ -793273,7 +796380,7 @@ }, { "sim":50.0, - "partner":"7xif" + "partner":"4pgc" }, { "sim":50.0, @@ -793287,6 +796394,10 @@ "sim":50.0, "partner":"7xii" }, + { + "sim":50.0, + "partner":"7xif" + }, { "sim":50.0, "partner":"5ybl" @@ -793371,14 +796482,6 @@ "sim":50.0, "partner":"7ohn" }, - { - "sim":50.0, - "partner":"2nq6" - }, - { - "sim":50.0, - "partner":"2nq7" - }, { "sim":50.0, "partner":"2b3k" @@ -793419,6 +796522,14 @@ "sim":50.0, "partner":"2gz5" }, + { + "sim":50.0, + "partner":"2nq6" + }, + { + "sim":50.0, + "partner":"2nq7" + }, { "sim":50.0, "partner":"5jyo" @@ -793505,20 +796616,12 @@ }, { "sim":50.0, - "partner":"6pi5" + "partner":"6pi6" }, { "sim":50.0, "partner":"6pii" }, - { - "sim":50.0, - "partner":"7ajm" - }, - { - "sim":50.0, - "partner":"6pi6" - }, { "sim":50.0, "partner":"7a4r" @@ -793533,23 +796636,11 @@ }, { "sim":50.0, - "partner":"7a53" - }, - { - "sim":50.0, - "partner":"7ajw" - }, - { - "sim":50.0, - "partner":"7akb" - }, - { - "sim":50.0, - "partner":"7ajy" + "partner":"6pi5" }, { "sim":50.0, - "partner":"7a5l" + "partner":"7ajm" }, { "sim":50.0, @@ -793589,11 +796680,11 @@ }, { "sim":50.0, - "partner":"4ilk" + "partner":"7aja" }, { "sim":50.0, - "partner":"7aja" + "partner":"4ilk" }, { "sim":50.0, @@ -793615,45 +796706,49 @@ "sim":50.0, "partner":"7aka" }, + { + "sim":50.0, + "partner":"7a53" + }, { "sim":50.0, "partner":"7akl" }, { "sim":50.0, - "partner":"8tne" + "partner":"7ajw" }, { "sim":50.0, - "partner":"4m1i" + "partner":"7akb" }, { "sim":50.0, - "partner":"4d8f" + "partner":"7ajy" }, { "sim":50.0, - "partner":"4d8g" + "partner":"7a5l" }, { "sim":50.0, - "partner":"4m1h" + "partner":"8tne" }, { "sim":50.0, - "partner":"7wxl" + "partner":"4d8f" }, { "sim":50.0, - "partner":"7wxm" + "partner":"4d8g" }, { "sim":50.0, - "partner":"7wxn" + "partner":"4m1h" }, { "sim":50.0, - "partner":"7wxo" + "partner":"4m1i" }, { "sim":50.0, @@ -793685,71 +796780,67 @@ }, { "sim":50.0, - "partner":"6wug" - }, - { - "sim":50.0, - "partner":"6wui" + "partner":"7wxl" }, { "sim":50.0, - "partner":"3a17" + "partner":"7wxm" }, { "sim":50.0, - "partner":"3a18" + "partner":"7wxn" }, { "sim":50.0, - "partner":"3a15" + "partner":"7wxo" }, { "sim":50.0, - "partner":"3a16" + "partner":"6wug" }, { "sim":50.0, - "partner":"2iua" + "partner":"6wui" }, { "sim":50.0, - "partner":"2iu8" + "partner":"3a17" }, { "sim":50.0, - "partner":"2iu9" + "partner":"3a18" }, { "sim":50.0, - "partner":"5eeg" + "partner":"3a15" }, { "sim":50.0, - "partner":"5jr3" + "partner":"3a16" }, { "sim":50.0, - "partner":"5eeh" + "partner":"2iu8" }, { "sim":50.0, - "partner":"5zzx" + "partner":"2iu9" }, { "sim":50.0, - "partner":"6a0d" + "partner":"2iua" }, { "sim":50.0, - "partner":"5zzy" + "partner":"5eeh" }, { "sim":50.0, - "partner":"6a0v" + "partner":"5eeg" }, { "sim":50.0, - "partner":"6k3f" + "partner":"5jr3" }, { "sim":50.0, @@ -793763,6 +796854,10 @@ "sim":50.0, "partner":"6a39" }, + { + "sim":50.0, + "partner":"6k3f" + }, { "sim":50.0, "partner":"6a00" @@ -793907,6 +797002,22 @@ "sim":50.0, "partner":"6a21" }, + { + "sim":50.0, + "partner":"5zzx" + }, + { + "sim":50.0, + "partner":"6a0d" + }, + { + "sim":50.0, + "partner":"5zzy" + }, + { + "sim":50.0, + "partner":"6a0v" + }, { "sim":50.0, "partner":"4rzs" @@ -793921,15 +797032,15 @@ }, { "sim":50.0, - "partner":"2o0h" + "partner":"2o0j" }, { "sim":50.0, - "partner":"2o0j" + "partner":"2o0k" }, { "sim":50.0, - "partner":"2o0k" + "partner":"2o0h" }, { "sim":50.0, @@ -793943,10 +797054,6 @@ "sim":50.0, "partner":"8t0u" }, - { - "sim":50.0, - "partner":"5hxu" - }, { "sim":50.0, "partner":"5hy1" @@ -793959,6 +797066,10 @@ "sim":50.0, "partner":"5hwe" }, + { + "sim":50.0, + "partner":"5hxu" + }, { "sim":50.0, "partner":"5vrd" @@ -793969,11 +797080,11 @@ }, { "sim":50.0, - "partner":"7sc6" + "partner":"7scq" }, { "sim":50.0, - "partner":"7scq" + "partner":"7sc6" }, { "sim":50.0, @@ -793993,11 +797104,11 @@ }, { "sim":50.0, - "partner":"8gqm" + "partner":"8gqf" }, { "sim":50.0, - "partner":"8gqf" + "partner":"8gqm" }, { "sim":50.0, @@ -794035,10 +797146,6 @@ "sim":50.0, "partner":"5xpj" }, - { - "sim":50.0, - "partner":"4euh" - }, { "sim":50.0, "partner":"4eue" @@ -794049,7 +797156,7 @@ }, { "sim":50.0, - "partner":"5dvi" + "partner":"4euh" }, { "sim":50.0, @@ -794059,13 +797166,17 @@ "sim":50.0, "partner":"1pie" }, + { + "sim":50.0, + "partner":"8f91" + }, { "sim":50.0, "partner":"5dvf" }, { "sim":50.0, - "partner":"8f91" + "partner":"5dvi" }, { "sim":50.0, @@ -794127,10 +797238,6 @@ "sim":50.0, "partner":"5ysm" }, - { - "sim":50.0, - "partner":"4tm4" - }, { "sim":50.0, "partner":"4tlx" @@ -794157,7 +797264,7 @@ }, { "sim":50.0, - "partner":"2imc" + "partner":"4tm4" }, { "sim":50.0, @@ -794183,6 +797290,10 @@ "sim":50.0, "partner":"2imb" }, + { + "sim":50.0, + "partner":"2imc" + }, { "sim":50.0, "partner":"5xwb" @@ -794203,10 +797314,6 @@ "sim":50.0, "partner":"8vwk" }, - { - "sim":50.0, - "partner":"7cqq" - }, { "sim":50.0, "partner":"7cqu" @@ -794221,16 +797328,20 @@ }, { "sim":50.0, - "partner":"3tkt" + "partner":"7cql" }, { "sim":50.0, - "partner":"7cql" + "partner":"3tkt" }, { "sim":50.0, "partner":"7cqn" }, + { + "sim":50.0, + "partner":"7cqq" + }, { "sim":50.0, "partner":"7lqx" @@ -794301,11 +797412,11 @@ }, { "sim":50.0, - "partner":"6vy9" + "partner":"6vya" }, { "sim":50.0, - "partner":"6vya" + "partner":"6vy9" }, { "sim":50.0, @@ -794313,15 +797424,15 @@ }, { "sim":50.0, - "partner":"4l2h" + "partner":"4epp" }, { "sim":50.0, - "partner":"4epp" + "partner":"4epq" }, { "sim":50.0, - "partner":"4epq" + "partner":"4l2h" }, { "sim":50.0, @@ -794423,10 +797534,6 @@ "sim":50.0, "partner":"3mjc" }, - { - "sim":50.0, - "partner":"6pt4" - }, { "sim":50.0, "partner":"6pt6" @@ -794439,6 +797546,18 @@ "sim":50.0, "partner":"6ptk" }, + { + "sim":50.0, + "partner":"6pt4" + }, + { + "sim":50.0, + "partner":"8oy9" + }, + { + "sim":50.0, + "partner":"8oy4" + }, { "sim":50.0, "partner":"8oya" @@ -794475,14 +797594,6 @@ "sim":50.0, "partner":"8oy3" }, - { - "sim":50.0, - "partner":"8oy9" - }, - { - "sim":50.0, - "partner":"8oy4" - }, { "sim":50.0, "partner":"6p4o" @@ -794651,10 +797762,6 @@ "sim":50.0, "partner":"8szc" }, - { - "sim":50.0, - "partner":"8t1p" - }, { "sim":50.0, "partner":"7m33" @@ -794667,6 +797774,10 @@ "sim":50.0, "partner":"8fpf" }, + { + "sim":50.0, + "partner":"8t1p" + }, { "sim":50.0, "partner":"8fmv" @@ -794709,15 +797820,15 @@ }, { "sim":50.0, - "partner":"2bpo" + "partner":"2bf4" }, { "sim":50.0, - "partner":"2bf4" + "partner":"2bn4" }, { "sim":50.0, - "partner":"2bn4" + "partner":"2bpo" }, { "sim":50.0, @@ -794739,21 +797850,17 @@ "sim":50.0, "partner":"3zw8" }, - { - "sim":50.0, - "partner":"3zw9" - }, { "sim":50.0, "partner":"6z5f" }, { "sim":50.0, - "partner":"3zwa" + "partner":"3zw9" }, { "sim":50.0, - "partner":"3zwb" + "partner":"3zwa" }, { "sim":50.0, @@ -794765,12 +797872,16 @@ }, { "sim":50.0, - "partner":"3zwc" + "partner":"3zwb" }, { "sim":50.0, "partner":"6zic" }, + { + "sim":50.0, + "partner":"3zwc" + }, { "sim":50.0, "partner":"5mgb" @@ -794825,11 +797936,11 @@ }, { "sim":50.0, - "partner":"4xc6" + "partner":"4xc7" }, { "sim":50.0, - "partner":"4xc7" + "partner":"4xc8" }, { "sim":50.0, @@ -794837,16 +797948,12 @@ }, { "sim":50.0, - "partner":"4xc8" + "partner":"5cjt" }, { "sim":50.0, "partner":"8ssl" }, - { - "sim":50.0, - "partner":"5cjt" - }, { "sim":50.0, "partner":"5cju" @@ -794858,6 +797965,10 @@ { "sim":50.0, "partner":"5cjw" + }, + { + "sim":50.0, + "partner":"4xc6" } ], "struct_thr_sim_designed":[ @@ -794868,7 +797979,7 @@ ], "seq_max_sim_designed":{ "sim":114.0, - "partner":"8qae" + "partner":"8qad" }, "seq_max_sim_natural":{ "sim":61.0, @@ -794960,90 +798071,90 @@ "alpha-helical barrel" ], "keywords":[ - "require", - "monomeric", - "channels", - "seeded", - "peptide", - "accelerating", - "including", - "pipelines", + "made", + "open", + "genes", + "defined", + "escherichia", + "minimizes", + "families", + "rapidly", + "short", + "protein", + "six", + "fully", + "novo", "throughout", - "parallel", + "match", + "motifs", + "pipelines", + "two", + "helices", + "adjacent", + "antiparallel", + "characterized", + "however", + "soluble", + "starting", + "define", + "residues", + "targets", + "connected", + "layer", + "bind", + "proteins", + "accelerating", + "process", + "accuracy", "outer", + "small", + "barrel", + "longer", + "computational", + "including", + "peptide", + "design", "sampling", - "sequences", - "expression", - "bind", - "synthetic", + "onto", + "express", "packed", - "escherichia", + "loops", + "maintained", + "oligomeric", + "namely", + "validated", + "connectors", + "coli", + "parallel", "building", - "however", - "starting", + "seeded", + "channels", + "states", + "sequence", + "peptides", + "describe", + "assemblies", + "advancing", + "central", "average", - "longer", - "connectors", - "proteins", "models", - "process", - "de", - "characterized", - "rapidly", + "sequences", + "require", "efficient", - "open", - "small", - "short", - "maintained", - "fully", - "made", - "match", - "onto", + "loop", "structures", + "de", + "70", + "synthetic", + "monomeric", "give", - "motifs", "molecules", - "layer", - "loops", - "connected", - "defined", - "families", - "assemblies", - "coli", - "70", - "namely", - "define", - "six", - "design", - "minimizes", - "express", - "soluble", - "states", "routes", - "describe", "high", - "sequence", - "genes", - "accuracy", - "designs", - "advancing", - "helices", - "barrels", - "novo", - "barrel", "sufficient", - "peptides", - "residues", - "adjacent", - "two", - "validated", - "antiparallel", - "central", - "protein", - "targets", - "computational", - "oligomeric", - "loop" + "expression", + "designs", + "barrels" ], "release_date":"2024-07-03", "publication":"\"Rationally seeded computational protein design of ɑ-helical barrels\", Nat.Chem.Biol., 20, 991-999", @@ -795197,90 +798308,90 @@ "alpha-helical barrel" ], "keywords":[ - "require", - "monomeric", - "channels", - "seeded", - "peptide", - "accelerating", - "including", - "pipelines", + "made", + "open", + "genes", + "defined", + "escherichia", + "minimizes", + "families", + "rapidly", + "short", + "protein", + "six", + "fully", + "novo", "throughout", - "parallel", + "match", + "motifs", + "pipelines", + "two", + "helices", + "adjacent", + "antiparallel", + "characterized", + "however", + "soluble", + "starting", + "define", + "residues", + "targets", + "connected", + "layer", + "bind", + "proteins", + "accelerating", + "process", + "accuracy", "outer", + "small", + "barrel", + "longer", + "computational", + "including", + "peptide", + "design", "sampling", - "sequences", - "expression", - "bind", - "synthetic", + "onto", + "express", "packed", - "escherichia", + "loops", + "maintained", + "oligomeric", + "namely", + "validated", + "connectors", + "coli", + "parallel", "building", - "however", - "starting", + "seeded", + "channels", + "states", + "sequence", + "peptides", + "describe", + "assemblies", + "advancing", + "central", "average", - "longer", - "connectors", - "proteins", "models", - "process", - "de", - "characterized", - "rapidly", + "sequences", + "require", "efficient", - "open", - "small", - "short", - "maintained", - "fully", - "made", - "match", - "onto", + "loop", "structures", + "de", + "70", + "synthetic", + "monomeric", "give", - "motifs", "molecules", - "layer", - "loops", - "connected", - "defined", - "families", - "assemblies", - "coli", - "70", - "namely", - "define", - "six", - "design", - "minimizes", - "express", - "soluble", - "states", "routes", - "describe", "high", - "sequence", - "genes", - "accuracy", - "designs", - "advancing", - "helices", - "barrels", - "novo", - "barrel", "sufficient", - "peptides", - "residues", - "adjacent", - "two", - "validated", - "antiparallel", - "central", - "protein", - "targets", - "computational", - "oligomeric", - "loop" + "expression", + "designs", + "barrels" ], "release_date":"2024-07-03", "publication":"\"Rationally seeded computational protein design of ɑ-helical barrels\", Nat.Chem.Biol., 20, 991-999", @@ -795462,90 +798573,90 @@ "alpha-helical barrel" ], "keywords":[ - "require", - "monomeric", - "channels", - "seeded", - "peptide", - "accelerating", - "including", - "pipelines", + "made", + "open", + "genes", + "defined", + "escherichia", + "minimizes", + "families", + "rapidly", + "short", + "protein", + "six", + "fully", + "novo", "throughout", - "parallel", + "match", + "motifs", + "pipelines", + "two", + "helices", + "adjacent", + "antiparallel", + "characterized", + "however", + "soluble", + "starting", + "define", + "residues", + "targets", + "connected", + "layer", + "bind", + "proteins", + "accelerating", + "process", + "accuracy", "outer", + "small", + "barrel", + "longer", + "computational", + "including", + "peptide", + "design", "sampling", - "sequences", - "expression", - "bind", - "synthetic", + "onto", + "express", "packed", - "escherichia", + "loops", + "maintained", + "oligomeric", + "namely", + "validated", + "connectors", + "coli", + "parallel", "building", - "however", - "starting", + "seeded", + "channels", + "states", + "sequence", + "peptides", + "describe", + "assemblies", + "advancing", + "central", "average", - "longer", - "connectors", - "proteins", "models", - "process", - "de", - "characterized", - "rapidly", + "sequences", + "require", "efficient", - "open", - "small", - "short", - "maintained", - "fully", - "made", - "match", - "onto", + "loop", "structures", + "de", + "70", + "synthetic", + "monomeric", "give", - "motifs", "molecules", - "layer", - "loops", - "connected", - "defined", - "families", - "assemblies", - "coli", - "70", - "namely", - "define", - "six", - "design", - "minimizes", - "express", - "soluble", - "states", "routes", - "describe", "high", - "sequence", - "genes", - "accuracy", - "designs", - "advancing", - "helices", - "barrels", - "novo", - "barrel", "sufficient", - "peptides", - "residues", - "adjacent", - "two", - "validated", - "antiparallel", - "central", - "protein", - "targets", - "computational", - "oligomeric", - "loop" + "expression", + "designs", + "barrels" ], "release_date":"2024-07-03", "publication":"\"Rationally seeded computational protein design of ɑ-helical barrels\", Nat.Chem.Biol., 20, 991-999", @@ -795727,51 +798838,51 @@ "seq_thr_sim_designed":[ { "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":342.0, - "partner":"4dui" + "partner":"9f8g" }, { "sim":342.0, - "partner":"8ql9" + "partner":"8ql6" }, { "sim":342.0, - "partner":"8ql8" + "partner":"8qla" }, { "sim":342.0, - "partner":"8ql3" + "partner":"8ql8" }, { "sim":342.0, - "partner":"9f8g" + "partner":"4dui" }, { "sim":342.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":342.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":342.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":342.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":342.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":342.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":298.0, @@ -795787,19 +798898,19 @@ }, { "sim":295.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":295.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":291.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":291.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":290.0, @@ -795855,11 +798966,11 @@ }, { "sim":261.0, - "partner":"7z72" + "partner":"7z7e" }, { "sim":261.0, - "partner":"7z7e" + "partner":"7z72" }, { "sim":259.0, @@ -795927,7 +799038,7 @@ }, { "sim":253.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":253.0, @@ -795935,7 +799046,7 @@ }, { "sim":253.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":252.0, @@ -795991,11 +799102,11 @@ }, { "sim":223.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":223.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":223.0, @@ -796019,11 +799130,11 @@ }, { "sim":207.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":207.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":205.0, @@ -796035,19 +799146,23 @@ }, { "sim":198.0, - "partner":"8rci" + "partner":"7z73" }, { "sim":198.0, - "partner":"7z73" + "partner":"8rci" }, { "sim":192.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":192.0, - "partner":"4qfv" + "partner":"4o60" + }, + { + "sim":187.0, + "partner":"9glq" }, { "sim":178.0, @@ -796095,30 +799210,18 @@ } ], "seq_thr_sim_natural":[ - { - "sim":342.0, - "partner":"7yz0" - }, { "sim":342.0, "partner":"6mzf" }, { "sim":342.0, - "partner":"7yz1" - }, - { - "sim":342.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":342.0, "partner":"5nqt" }, - { - "sim":342.0, - "partner":"6mze" - }, { "sim":342.0, "partner":"7yz2" @@ -796129,11 +799232,11 @@ }, { "sim":342.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":342.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":342.0, @@ -796145,23 +799248,23 @@ }, { "sim":342.0, - "partner":"4lnu" + "partner":"7yz6" }, { "sim":342.0, - "partner":"7yz6" + "partner":"4lnu" }, { "sim":342.0, - "partner":"4drx" + "partner":"6zwb" }, { "sim":342.0, - "partner":"5nm5" + "partner":"4drx" }, { "sim":342.0, - "partner":"6zwb" + "partner":"5nm5" }, { "sim":342.0, @@ -796175,6 +799278,18 @@ "sim":342.0, "partner":"7yyz" }, + { + "sim":342.0, + "partner":"7yz0" + }, + { + "sim":342.0, + "partner":"7yz1" + }, + { + "sim":342.0, + "partner":"7z01" + }, { "sim":338.0, "partner":"6bbn" @@ -796205,11 +799320,11 @@ }, { "sim":315.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":315.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":312.0, @@ -796273,27 +799388,19 @@ }, { "sim":290.0, - "partner":"5eno" - }, - { - "sim":290.0, - "partner":"6zob" - }, - { - "sim":290.0, - "partner":"6zo5" + "partner":"4dx6" }, { "sim":290.0, - "partner":"4dx6" + "partner":"6sgs" }, { "sim":290.0, - "partner":"6q4n" + "partner":"6zoc" }, { "sim":290.0, - "partner":"6zoc" + "partner":"6zo6" }, { "sim":290.0, @@ -796301,11 +799408,11 @@ }, { "sim":290.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":290.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":290.0, @@ -796313,11 +799420,11 @@ }, { "sim":290.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":290.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":290.0, @@ -796325,11 +799432,7 @@ }, { "sim":290.0, - "partner":"6zod" - }, - { - "sim":290.0, - "partner":"7b8r" + "partner":"6zo7" }, { "sim":290.0, @@ -796337,23 +799440,23 @@ }, { "sim":290.0, - "partner":"5enq" + "partner":"6zoe" }, { "sim":290.0, - "partner":"6zo7" + "partner":"5enq" }, { "sim":290.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":290.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":290.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":290.0, @@ -796369,24 +799472,28 @@ }, { "sim":290.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":290.0, - "partner":"3noc" + "partner":"6zof" }, { "sim":290.0, - "partner":"6zo8" + "partner":"3noc" }, { "sim":290.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":290.0, "partner":"5enr" }, + { + "sim":290.0, + "partner":"7oul" + }, { "sim":290.0, "partner":"1svx" @@ -796397,39 +799504,39 @@ }, { "sim":290.0, - "partner":"6sgu" + "partner":"7b8t" }, { "sim":290.0, - "partner":"7oul" + "partner":"6zo9" }, { "sim":290.0, - "partner":"5nc5" + "partner":"6zog" }, { "sim":290.0, - "partner":"6zo9" + "partner":"5nc5" }, { "sim":290.0, - "partner":"6zog" + "partner":"7oum" }, { "sim":290.0, - "partner":"7b8t" + "partner":"5ens" }, { "sim":290.0, - "partner":"5ens" + "partner":"5en5" }, { "sim":290.0, - "partner":"7oum" + "partner":"6zoa" }, { "sim":290.0, - "partner":"5en5" + "partner":"6zoh" }, { "sim":290.0, @@ -796437,11 +799544,11 @@ }, { "sim":290.0, - "partner":"6zoa" + "partner":"6d65" }, { "sim":290.0, - "partner":"6zoh" + "partner":"6sgr" }, { "sim":290.0, @@ -796457,15 +799564,23 @@ }, { "sim":290.0, - "partner":"6d65" + "partner":"6zob" }, { "sim":290.0, - "partner":"6sgr" + "partner":"4dx5" }, { "sim":290.0, - "partner":"4dx5" + "partner":"5eno" + }, + { + "sim":290.0, + "partner":"6zo5" + }, + { + "sim":290.0, + "partner":"6q4n" }, { "sim":289.0, @@ -796523,10 +799638,6 @@ "sim":274.0, "partner":"6gcu" }, - { - "sim":274.0, - "partner":"8tzb" - }, { "sim":274.0, "partner":"8tzc" @@ -796543,6 +799654,10 @@ "sim":274.0, "partner":"8tzh" }, + { + "sim":274.0, + "partner":"8tzb" + }, { "sim":274.0, "partner":"5lel" @@ -796649,11 +799764,11 @@ }, { "sim":262.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":262.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":262.0, @@ -796701,11 +799816,11 @@ }, { "sim":258.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":258.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":256.0, @@ -796747,10 +799862,6 @@ "sim":247.0, "partner":"6qev" }, - { - "sim":246.0, - "partner":"8g4f" - }, { "sim":246.0, "partner":"8g42" @@ -796767,6 +799878,10 @@ "sim":246.0, "partner":"8g3k" }, + { + "sim":246.0, + "partner":"8g4f" + }, { "sim":246.0, "partner":"6sh9" @@ -796777,11 +799892,11 @@ }, { "sim":244.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":244.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":244.0, @@ -796793,11 +799908,11 @@ }, { "sim":242.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":242.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":240.0, @@ -796903,10 +800018,6 @@ "sim":228.0, "partner":"4hrn" }, - { - "sim":228.0, - "partner":"7pd8" - }, { "sim":228.0, "partner":"7pdd" @@ -796919,6 +800030,10 @@ "sim":228.0, "partner":"7pdh" }, + { + "sim":228.0, + "partner":"7pd8" + }, { "sim":224.0, "partner":"6moj" @@ -797057,23 +800172,23 @@ }, { "sim":119.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":119.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":119.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":119.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":119.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":119.0, @@ -797081,11 +800196,11 @@ }, { "sim":119.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":119.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":119.0, @@ -797159,10 +800274,6 @@ "sim":103.0, "partner":"2l6b" }, - { - "sim":103.0, - "partner":"5vhj" - }, { "sim":103.0, "partner":"5vhh" @@ -797193,15 +800304,15 @@ }, { "sim":103.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":103.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":103.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":103.0, @@ -797211,6 +800322,10 @@ "sim":103.0, "partner":"7vxw" }, + { + "sim":103.0, + "partner":"1uoh" + }, { "sim":103.0, "partner":"7vy4" @@ -797221,11 +800336,11 @@ }, { "sim":103.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":103.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":103.0, @@ -797237,15 +800352,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":102.0, @@ -797285,11 +800400,11 @@ }, { "sim":102.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":102.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":100.0, @@ -797317,11 +800432,11 @@ }, { "sim":99.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":99.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":99.0, @@ -797401,15 +800516,15 @@ }, { "sim":91.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":91.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":91.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":91.0, @@ -797429,16 +800544,24 @@ }, { "sim":90.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":90.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":90.0, "partner":"7roy" }, + { + "sim":90.0, + "partner":"8wqg" + }, + { + "sim":90.0, + "partner":"8wqe" + }, { "sim":90.0, "partner":"8wqh" @@ -797467,14 +800590,6 @@ "sim":90.0, "partner":"8wqd" }, - { - "sim":90.0, - "partner":"8wqg" - }, - { - "sim":90.0, - "partner":"8wqe" - }, { "sim":90.0, "partner":"8je1" @@ -797607,10 +800722,6 @@ "sim":84.0, "partner":"6e2g" }, - { - "sim":84.0, - "partner":"6v9x" - }, { "sim":84.0, "partner":"6v9y" @@ -797623,6 +800734,10 @@ "sim":84.0, "partner":"6v9w" }, + { + "sim":84.0, + "partner":"6v9x" + }, { "sim":84.0, "partner":"7or0" @@ -797743,10 +800858,6 @@ "sim":80.0, "partner":"5wo6" }, - { - "sim":80.0, - "partner":"5iwr" - }, { "sim":80.0, "partner":"5iwt" @@ -797801,11 +800912,11 @@ }, { "sim":80.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":80.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":80.0, @@ -797845,11 +800956,7 @@ }, { "sim":80.0, - "partner":"7t6m" - }, - { - "sim":80.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":80.0, @@ -797885,15 +800992,19 @@ }, { "sim":80.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":80.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":80.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":80.0, + "partner":"7t6k" }, { "sim":80.0, @@ -797901,7 +801012,7 @@ }, { "sim":80.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":80.0, @@ -797909,7 +801020,11 @@ }, { "sim":80.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":80.0, + "partner":"8ffn" }, { "sim":79.0, @@ -797923,14 +801038,6 @@ "sim":79.0, "partner":"6kyk" }, - { - "sim":78.0, - "partner":"3aaa" - }, - { - "sim":78.0, - "partner":"7dsb" - }, { "sim":78.0, "partner":"7df7" @@ -797941,15 +801048,15 @@ }, { "sim":78.0, - "partner":"2he0" + "partner":"7dsb" }, { "sim":78.0, - "partner":"6m11" + "partner":"3aaa" }, { "sim":78.0, - "partner":"6m12" + "partner":"2he0" }, { "sim":78.0, @@ -797975,6 +801082,14 @@ "sim":78.0, "partner":"4o1p" }, + { + "sim":78.0, + "partner":"6m11" + }, + { + "sim":78.0, + "partner":"6m12" + }, { "sim":78.0, "partner":"6aun" @@ -798053,11 +801168,11 @@ }, { "sim":74.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":74.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":74.0, @@ -798083,10 +801198,6 @@ "sim":73.0, "partner":"8sp8" }, - { - "sim":73.0, - "partner":"7k4a" - }, { "sim":73.0, "partner":"7k4b" @@ -798109,7 +801220,7 @@ }, { "sim":73.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":73.0, @@ -798125,7 +801236,7 @@ }, { "sim":73.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":73.0, @@ -798137,7 +801248,7 @@ }, { "sim":73.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":73.0, @@ -798155,6 +801266,10 @@ "sim":73.0, "partner":"6bo8" }, + { + "sim":73.0, + "partner":"6bo9" + }, { "sim":72.0, "partner":"1bi7" @@ -798197,15 +801312,15 @@ }, { "sim":68.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":68.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":68.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":68.0, @@ -798365,19 +801480,19 @@ }, { "sim":50.0, - "partner":"8u43" + "partner":"8u2z" }, { "sim":50.0, - "partner":"8u4d" + "partner":"8u43" }, { "sim":50.0, - "partner":"8u3a" + "partner":"8u4d" }, { "sim":50.0, - "partner":"8u2z" + "partner":"8u3a" }, { "sim":50.0, @@ -798391,18 +801506,10 @@ "sim":50.0, "partner":"5is0" }, - { - "sim":50.0, - "partner":"7mzc" - }, { "sim":50.0, "partner":"7l2v" }, - { - "sim":50.0, - "partner":"8t3l" - }, { "sim":50.0, "partner":"7mzd" @@ -798413,7 +801520,7 @@ }, { "sim":50.0, - "partner":"8t3m" + "partner":"8t3l" }, { "sim":50.0, @@ -798431,6 +801538,10 @@ "sim":50.0, "partner":"7l2x" }, + { + "sim":50.0, + "partner":"8t3m" + }, { "sim":50.0, "partner":"7l2r" @@ -798465,35 +801576,35 @@ }, { "sim":50.0, - "partner":"8t0y" + "partner":"7mzc" }, { "sim":50.0, - "partner":"8u3l" + "partner":"8t0y" }, { "sim":50.0, - "partner":"8t0c" + "partner":"8u30" }, { "sim":50.0, - "partner":"8u30" + "partner":"8u3c" }, { "sim":50.0, - "partner":"8t0e" + "partner":"8t0c" }, { "sim":50.0, - "partner":"8t10" + "partner":"8t0e" }, { "sim":50.0, - "partner":"8u3c" + "partner":"8t10" }, { "sim":50.0, - "partner":"7l2n" + "partner":"8u3l" }, { "sim":50.0, @@ -798529,32 +801640,28 @@ }, { "sim":50.0, - "partner":"7lqy" + "partner":"7l2n" }, { "sim":50.0, - "partner":"7lqz" + "partner":"7lqy" }, { "sim":50.0, - "partner":"7lr0" + "partner":"7lqz" }, { "sim":50.0, - "partner":"7lpd" + "partner":"7lr0" }, { "sim":50.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":50.0, "partner":"7rqv" }, - { - "sim":50.0, - "partner":"7lpe" - }, { "sim":50.0, "partner":"7rqw" @@ -798586,6 +801693,14 @@ { "sim":50.0, "partner":"7lpc" + }, + { + "sim":50.0, + "partner":"7rqu" + }, + { + "sim":50.0, + "partner":"7lpd" } ], "struct_thr_sim_designed":[ @@ -798822,11 +801937,11 @@ ], "seq_max_sim_designed":{ "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, "seq_max_sim_natural":{ "sim":342.0, - "partner":"7yz0" + "partner":"6mzf" }, "struct_max_sim_designed":{ "sim":1.0, @@ -798914,90 +802029,90 @@ "alpha-helical barrel" ], "keywords":[ - "require", - "monomeric", - "channels", - "seeded", - "peptide", - "accelerating", - "including", - "pipelines", + "made", + "open", + "genes", + "defined", + "escherichia", + "minimizes", + "families", + "rapidly", + "short", + "protein", + "six", + "fully", + "novo", "throughout", - "parallel", + "match", + "motifs", + "pipelines", + "two", + "helices", + "adjacent", + "antiparallel", + "characterized", + "however", + "soluble", + "starting", + "define", + "residues", + "targets", + "connected", + "layer", + "bind", + "proteins", + "accelerating", + "process", + "accuracy", "outer", + "small", + "barrel", + "longer", + "computational", + "including", + "peptide", + "design", "sampling", - "sequences", - "expression", - "bind", - "synthetic", + "onto", + "express", "packed", - "escherichia", + "loops", + "maintained", + "oligomeric", + "namely", + "validated", + "connectors", + "coli", + "parallel", "building", - "however", - "starting", + "seeded", + "channels", + "states", + "sequence", + "peptides", + "describe", + "assemblies", + "advancing", + "central", "average", - "longer", - "connectors", - "proteins", "models", - "process", - "de", - "characterized", - "rapidly", + "sequences", + "require", "efficient", - "open", - "small", - "short", - "maintained", - "fully", - "made", - "match", - "onto", + "loop", "structures", + "de", + "70", + "synthetic", + "monomeric", "give", - "motifs", "molecules", - "layer", - "loops", - "connected", - "defined", - "families", - "assemblies", - "coli", - "70", - "namely", - "define", - "six", - "design", - "minimizes", - "express", - "soluble", - "states", "routes", - "describe", "high", - "sequence", - "genes", - "accuracy", - "designs", - "advancing", - "helices", - "barrels", - "novo", - "barrel", "sufficient", - "peptides", - "residues", - "adjacent", - "two", - "validated", - "antiparallel", - "central", - "protein", - "targets", - "computational", - "oligomeric", - "loop" + "expression", + "designs", + "barrels" ], "release_date":"2024-07-03", "publication":"\"Rationally seeded computational protein design of ɑ-helical barrels\", Nat.Chem.Biol., 20, 991-999", @@ -799171,19 +802286,19 @@ "seq_thr_sim_designed":[ { "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":342.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":342.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":342.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":342.0, @@ -799191,31 +802306,31 @@ }, { "sim":342.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":342.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":342.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":342.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":342.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":342.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":342.0, - "partner":"8qlb" + "partner":"8ql5" }, { "sim":298.0, @@ -799231,19 +802346,19 @@ }, { "sim":295.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":295.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":291.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":291.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":290.0, @@ -799299,11 +802414,11 @@ }, { "sim":261.0, - "partner":"7z72" + "partner":"7z7e" }, { "sim":261.0, - "partner":"7z7e" + "partner":"7z72" }, { "sim":259.0, @@ -799371,7 +802486,7 @@ }, { "sim":253.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":253.0, @@ -799379,7 +802494,7 @@ }, { "sim":253.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":252.0, @@ -799435,11 +802550,11 @@ }, { "sim":223.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":223.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":223.0, @@ -799463,11 +802578,11 @@ }, { "sim":207.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":207.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":205.0, @@ -799479,19 +802594,23 @@ }, { "sim":198.0, - "partner":"8rci" + "partner":"7z73" }, { "sim":198.0, - "partner":"7z73" + "partner":"8rci" }, { "sim":192.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":192.0, - "partner":"4qfv" + "partner":"4o60" + }, + { + "sim":187.0, + "partner":"9glq" }, { "sim":178.0, @@ -799539,30 +802658,18 @@ } ], "seq_thr_sim_natural":[ - { - "sim":342.0, - "partner":"7yz0" - }, { "sim":342.0, "partner":"6mzf" }, { "sim":342.0, - "partner":"7yz1" - }, - { - "sim":342.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":342.0, "partner":"5nqt" }, - { - "sim":342.0, - "partner":"6mze" - }, { "sim":342.0, "partner":"7yz2" @@ -799573,11 +802680,11 @@ }, { "sim":342.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":342.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":342.0, @@ -799589,23 +802696,23 @@ }, { "sim":342.0, - "partner":"4lnu" + "partner":"7yz6" }, { "sim":342.0, - "partner":"7yz6" + "partner":"4lnu" }, { "sim":342.0, - "partner":"4drx" + "partner":"6zwb" }, { "sim":342.0, - "partner":"5nm5" + "partner":"4drx" }, { "sim":342.0, - "partner":"6zwb" + "partner":"5nm5" }, { "sim":342.0, @@ -799619,6 +802726,18 @@ "sim":342.0, "partner":"7yyz" }, + { + "sim":342.0, + "partner":"7yz0" + }, + { + "sim":342.0, + "partner":"7yz1" + }, + { + "sim":342.0, + "partner":"7z01" + }, { "sim":338.0, "partner":"6bbn" @@ -799649,11 +802768,11 @@ }, { "sim":315.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":315.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":312.0, @@ -799717,27 +802836,19 @@ }, { "sim":290.0, - "partner":"5eno" - }, - { - "sim":290.0, - "partner":"6zob" - }, - { - "sim":290.0, - "partner":"6zo5" + "partner":"4dx6" }, { "sim":290.0, - "partner":"4dx6" + "partner":"6sgs" }, { "sim":290.0, - "partner":"6q4n" + "partner":"6zoc" }, { "sim":290.0, - "partner":"6zoc" + "partner":"6zo6" }, { "sim":290.0, @@ -799745,11 +802856,11 @@ }, { "sim":290.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":290.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":290.0, @@ -799757,11 +802868,11 @@ }, { "sim":290.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":290.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":290.0, @@ -799769,11 +802880,7 @@ }, { "sim":290.0, - "partner":"6zod" - }, - { - "sim":290.0, - "partner":"7b8r" + "partner":"6zo7" }, { "sim":290.0, @@ -799781,23 +802888,23 @@ }, { "sim":290.0, - "partner":"5enq" + "partner":"6zoe" }, { "sim":290.0, - "partner":"6zo7" + "partner":"5enq" }, { "sim":290.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":290.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":290.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":290.0, @@ -799813,24 +802920,28 @@ }, { "sim":290.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":290.0, - "partner":"3noc" + "partner":"6zof" }, { "sim":290.0, - "partner":"6zo8" + "partner":"3noc" }, { "sim":290.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":290.0, "partner":"5enr" }, + { + "sim":290.0, + "partner":"7oul" + }, { "sim":290.0, "partner":"1svx" @@ -799841,39 +802952,39 @@ }, { "sim":290.0, - "partner":"6sgu" + "partner":"7b8t" }, { "sim":290.0, - "partner":"7oul" + "partner":"6zo9" }, { "sim":290.0, - "partner":"5nc5" + "partner":"6zog" }, { "sim":290.0, - "partner":"6zo9" + "partner":"5nc5" }, { "sim":290.0, - "partner":"6zog" + "partner":"7oum" }, { "sim":290.0, - "partner":"7b8t" + "partner":"5ens" }, { "sim":290.0, - "partner":"5ens" + "partner":"5en5" }, { "sim":290.0, - "partner":"7oum" + "partner":"6zoa" }, { "sim":290.0, - "partner":"5en5" + "partner":"6zoh" }, { "sim":290.0, @@ -799881,11 +802992,11 @@ }, { "sim":290.0, - "partner":"6zoa" + "partner":"6d65" }, { "sim":290.0, - "partner":"6zoh" + "partner":"6sgr" }, { "sim":290.0, @@ -799901,15 +803012,23 @@ }, { "sim":290.0, - "partner":"6d65" + "partner":"6zob" }, { "sim":290.0, - "partner":"6sgr" + "partner":"4dx5" }, { "sim":290.0, - "partner":"4dx5" + "partner":"5eno" + }, + { + "sim":290.0, + "partner":"6zo5" + }, + { + "sim":290.0, + "partner":"6q4n" }, { "sim":289.0, @@ -799967,10 +803086,6 @@ "sim":274.0, "partner":"6gcu" }, - { - "sim":274.0, - "partner":"8tzb" - }, { "sim":274.0, "partner":"8tzc" @@ -799987,6 +803102,10 @@ "sim":274.0, "partner":"8tzh" }, + { + "sim":274.0, + "partner":"8tzb" + }, { "sim":274.0, "partner":"5lel" @@ -800097,11 +803216,11 @@ }, { "sim":262.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":262.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":262.0, @@ -800149,11 +803268,11 @@ }, { "sim":258.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":258.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":256.0, @@ -800195,10 +803314,6 @@ "sim":247.0, "partner":"6qev" }, - { - "sim":246.0, - "partner":"8g4f" - }, { "sim":246.0, "partner":"8g42" @@ -800215,6 +803330,10 @@ "sim":246.0, "partner":"8g3k" }, + { + "sim":246.0, + "partner":"8g4f" + }, { "sim":246.0, "partner":"6sh9" @@ -800225,11 +803344,11 @@ }, { "sim":244.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":244.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":244.0, @@ -800241,11 +803360,11 @@ }, { "sim":242.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":242.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":240.0, @@ -800351,10 +803470,6 @@ "sim":228.0, "partner":"4hrn" }, - { - "sim":228.0, - "partner":"7pd8" - }, { "sim":228.0, "partner":"7pdd" @@ -800367,6 +803482,10 @@ "sim":228.0, "partner":"7pdh" }, + { + "sim":228.0, + "partner":"7pd8" + }, { "sim":224.0, "partner":"6moj" @@ -800505,23 +803624,23 @@ }, { "sim":119.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":119.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":119.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":119.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":119.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":119.0, @@ -800529,11 +803648,11 @@ }, { "sim":119.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":119.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":119.0, @@ -800607,10 +803726,6 @@ "sim":103.0, "partner":"2l6b" }, - { - "sim":103.0, - "partner":"5vhj" - }, { "sim":103.0, "partner":"5vhh" @@ -800641,15 +803756,15 @@ }, { "sim":103.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":103.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":103.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":103.0, @@ -800659,6 +803774,10 @@ "sim":103.0, "partner":"7vxw" }, + { + "sim":103.0, + "partner":"1uoh" + }, { "sim":103.0, "partner":"7vy4" @@ -800669,11 +803788,11 @@ }, { "sim":103.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":103.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":103.0, @@ -800685,15 +803804,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":102.0, @@ -800733,11 +803852,11 @@ }, { "sim":102.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":102.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":100.0, @@ -800765,11 +803884,11 @@ }, { "sim":99.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":99.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":99.0, @@ -800849,15 +803968,15 @@ }, { "sim":91.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":91.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":91.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":91.0, @@ -800877,16 +803996,24 @@ }, { "sim":90.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":90.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":90.0, "partner":"7roy" }, + { + "sim":90.0, + "partner":"8wqg" + }, + { + "sim":90.0, + "partner":"8wqe" + }, { "sim":90.0, "partner":"8wqh" @@ -800915,14 +804042,6 @@ "sim":90.0, "partner":"8wqd" }, - { - "sim":90.0, - "partner":"8wqg" - }, - { - "sim":90.0, - "partner":"8wqe" - }, { "sim":90.0, "partner":"8je1" @@ -801067,10 +804186,6 @@ "sim":84.0, "partner":"6e2g" }, - { - "sim":84.0, - "partner":"6v9x" - }, { "sim":84.0, "partner":"6v9y" @@ -801083,6 +804198,10 @@ "sim":84.0, "partner":"6v9w" }, + { + "sim":84.0, + "partner":"6v9x" + }, { "sim":84.0, "partner":"7or0" @@ -801203,10 +804322,6 @@ "sim":80.0, "partner":"5wo6" }, - { - "sim":80.0, - "partner":"5iwr" - }, { "sim":80.0, "partner":"5iwt" @@ -801261,11 +804376,11 @@ }, { "sim":80.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":80.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":80.0, @@ -801305,11 +804420,7 @@ }, { "sim":80.0, - "partner":"7t6m" - }, - { - "sim":80.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":80.0, @@ -801345,15 +804456,19 @@ }, { "sim":80.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":80.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":80.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":80.0, + "partner":"7t6k" }, { "sim":80.0, @@ -801361,7 +804476,7 @@ }, { "sim":80.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":80.0, @@ -801369,7 +804484,11 @@ }, { "sim":80.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":80.0, + "partner":"8ffn" }, { "sim":79.0, @@ -801383,14 +804502,6 @@ "sim":79.0, "partner":"6kyk" }, - { - "sim":78.0, - "partner":"3aaa" - }, - { - "sim":78.0, - "partner":"7dsb" - }, { "sim":78.0, "partner":"7df7" @@ -801401,15 +804512,15 @@ }, { "sim":78.0, - "partner":"2he0" + "partner":"7dsb" }, { "sim":78.0, - "partner":"6m11" + "partner":"3aaa" }, { "sim":78.0, - "partner":"6m12" + "partner":"2he0" }, { "sim":78.0, @@ -801435,6 +804546,14 @@ "sim":78.0, "partner":"4o1p" }, + { + "sim":78.0, + "partner":"6m11" + }, + { + "sim":78.0, + "partner":"6m12" + }, { "sim":78.0, "partner":"6aun" @@ -801513,11 +804632,11 @@ }, { "sim":74.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":74.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":74.0, @@ -801543,10 +804662,6 @@ "sim":73.0, "partner":"8sp8" }, - { - "sim":73.0, - "partner":"7k4a" - }, { "sim":73.0, "partner":"7k4b" @@ -801569,7 +804684,7 @@ }, { "sim":73.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":73.0, @@ -801585,7 +804700,7 @@ }, { "sim":73.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":73.0, @@ -801597,7 +804712,7 @@ }, { "sim":73.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":73.0, @@ -801615,6 +804730,10 @@ "sim":73.0, "partner":"6bo8" }, + { + "sim":73.0, + "partner":"6bo9" + }, { "sim":72.0, "partner":"1bi7" @@ -801657,15 +804776,15 @@ }, { "sim":68.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":68.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":68.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":68.0, @@ -801825,19 +804944,19 @@ }, { "sim":50.0, - "partner":"8u43" + "partner":"8u2z" }, { "sim":50.0, - "partner":"8u4d" + "partner":"8u43" }, { "sim":50.0, - "partner":"8u3a" + "partner":"8u4d" }, { "sim":50.0, - "partner":"8u2z" + "partner":"8u3a" }, { "sim":50.0, @@ -801851,18 +804970,10 @@ "sim":50.0, "partner":"5is0" }, - { - "sim":50.0, - "partner":"7mzc" - }, { "sim":50.0, "partner":"7l2v" }, - { - "sim":50.0, - "partner":"8t3l" - }, { "sim":50.0, "partner":"7mzd" @@ -801873,7 +804984,7 @@ }, { "sim":50.0, - "partner":"8t3m" + "partner":"8t3l" }, { "sim":50.0, @@ -801891,6 +805002,10 @@ "sim":50.0, "partner":"7l2x" }, + { + "sim":50.0, + "partner":"8t3m" + }, { "sim":50.0, "partner":"7l2r" @@ -801925,35 +805040,35 @@ }, { "sim":50.0, - "partner":"8t0y" + "partner":"7mzc" }, { "sim":50.0, - "partner":"8u3l" + "partner":"8t0y" }, { "sim":50.0, - "partner":"8t0c" + "partner":"8u30" }, { "sim":50.0, - "partner":"8u30" + "partner":"8u3c" }, { "sim":50.0, - "partner":"8t0e" + "partner":"8t0c" }, { "sim":50.0, - "partner":"8t10" + "partner":"8t0e" }, { "sim":50.0, - "partner":"8u3c" + "partner":"8t10" }, { "sim":50.0, - "partner":"7l2n" + "partner":"8u3l" }, { "sim":50.0, @@ -801989,32 +805104,28 @@ }, { "sim":50.0, - "partner":"7lqy" + "partner":"7l2n" }, { "sim":50.0, - "partner":"7lqz" + "partner":"7lqy" }, { "sim":50.0, - "partner":"7lr0" + "partner":"7lqz" }, { "sim":50.0, - "partner":"7lpd" + "partner":"7lr0" }, { "sim":50.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":50.0, "partner":"7rqv" }, - { - "sim":50.0, - "partner":"7lpe" - }, { "sim":50.0, "partner":"7rqw" @@ -802046,6 +805157,14 @@ { "sim":50.0, "partner":"7lpc" + }, + { + "sim":50.0, + "partner":"7rqu" + }, + { + "sim":50.0, + "partner":"7lpd" } ], "struct_thr_sim_designed":[ @@ -802278,11 +805397,11 @@ ], "seq_max_sim_designed":{ "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, "seq_max_sim_natural":{ "sim":342.0, - "partner":"7yz0" + "partner":"6mzf" }, "struct_max_sim_designed":{ "sim":1.0, @@ -802402,19 +805521,15 @@ "seq_thr_sim_designed":[ { "sim":342.0, - "partner":"8qla" - }, - { - "sim":342.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":342.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":342.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":342.0, @@ -802422,19 +805537,19 @@ }, { "sim":342.0, - "partner":"9f8g" + "partner":"4dui" }, { "sim":342.0, - "partner":"8ql6" + "partner":"8qea" }, { "sim":342.0, - "partner":"8ql5" + "partner":"8qlb" }, { "sim":342.0, - "partner":"8ql4" + "partner":"8ql9" }, { "sim":342.0, @@ -802442,12 +805557,16 @@ }, { "sim":342.0, - "partner":"8qlb" + "partner":"8ql4" }, { "sim":342.0, "partner":"8ql2" }, + { + "sim":342.0, + "partner":"8ql5" + }, { "sim":298.0, "partner":"7dnf" @@ -802462,19 +805581,19 @@ }, { "sim":295.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":295.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":291.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":291.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":290.0, @@ -802530,11 +805649,11 @@ }, { "sim":261.0, - "partner":"7z72" + "partner":"7z7e" }, { "sim":261.0, - "partner":"7z7e" + "partner":"7z72" }, { "sim":259.0, @@ -802602,7 +805721,7 @@ }, { "sim":253.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":253.0, @@ -802610,7 +805729,7 @@ }, { "sim":253.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":252.0, @@ -802666,11 +805785,11 @@ }, { "sim":223.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":223.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":223.0, @@ -802694,11 +805813,11 @@ }, { "sim":207.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":207.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":205.0, @@ -802710,19 +805829,23 @@ }, { "sim":198.0, - "partner":"8rci" + "partner":"7z73" }, { "sim":198.0, - "partner":"7z73" + "partner":"8rci" }, { "sim":192.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":192.0, - "partner":"4qfv" + "partner":"4o60" + }, + { + "sim":187.0, + "partner":"9glq" }, { "sim":178.0, @@ -802770,30 +805893,18 @@ } ], "seq_thr_sim_natural":[ - { - "sim":342.0, - "partner":"7yz0" - }, { "sim":342.0, "partner":"6mzf" }, { "sim":342.0, - "partner":"7yz1" - }, - { - "sim":342.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":342.0, "partner":"5nqt" }, - { - "sim":342.0, - "partner":"6mze" - }, { "sim":342.0, "partner":"7yz2" @@ -802804,11 +805915,11 @@ }, { "sim":342.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":342.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":342.0, @@ -802820,23 +805931,23 @@ }, { "sim":342.0, - "partner":"4lnu" + "partner":"7yz6" }, { "sim":342.0, - "partner":"7yz6" + "partner":"4lnu" }, { "sim":342.0, - "partner":"4drx" + "partner":"6zwb" }, { "sim":342.0, - "partner":"5nm5" + "partner":"4drx" }, { "sim":342.0, - "partner":"6zwb" + "partner":"5nm5" }, { "sim":342.0, @@ -802850,6 +805961,18 @@ "sim":342.0, "partner":"7yyz" }, + { + "sim":342.0, + "partner":"7yz0" + }, + { + "sim":342.0, + "partner":"7yz1" + }, + { + "sim":342.0, + "partner":"7z01" + }, { "sim":338.0, "partner":"6bbn" @@ -802880,11 +806003,11 @@ }, { "sim":315.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":315.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":312.0, @@ -802948,27 +806071,19 @@ }, { "sim":290.0, - "partner":"5eno" - }, - { - "sim":290.0, - "partner":"6zob" - }, - { - "sim":290.0, - "partner":"6zo5" + "partner":"4dx6" }, { "sim":290.0, - "partner":"4dx6" + "partner":"6sgs" }, { "sim":290.0, - "partner":"6q4n" + "partner":"6zoc" }, { "sim":290.0, - "partner":"6zoc" + "partner":"6zo6" }, { "sim":290.0, @@ -802976,11 +806091,11 @@ }, { "sim":290.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":290.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":290.0, @@ -802988,11 +806103,11 @@ }, { "sim":290.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":290.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":290.0, @@ -803000,11 +806115,7 @@ }, { "sim":290.0, - "partner":"6zod" - }, - { - "sim":290.0, - "partner":"7b8r" + "partner":"6zo7" }, { "sim":290.0, @@ -803012,23 +806123,23 @@ }, { "sim":290.0, - "partner":"5enq" + "partner":"6zoe" }, { "sim":290.0, - "partner":"6zo7" + "partner":"5enq" }, { "sim":290.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":290.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":290.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":290.0, @@ -803044,24 +806155,28 @@ }, { "sim":290.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":290.0, - "partner":"3noc" + "partner":"6zof" }, { "sim":290.0, - "partner":"6zo8" + "partner":"3noc" }, { "sim":290.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":290.0, "partner":"5enr" }, + { + "sim":290.0, + "partner":"7oul" + }, { "sim":290.0, "partner":"1svx" @@ -803072,39 +806187,39 @@ }, { "sim":290.0, - "partner":"6sgu" + "partner":"7b8t" }, { "sim":290.0, - "partner":"7oul" + "partner":"6zo9" }, { "sim":290.0, - "partner":"5nc5" + "partner":"6zog" }, { "sim":290.0, - "partner":"6zo9" + "partner":"5nc5" }, { "sim":290.0, - "partner":"6zog" + "partner":"7oum" }, { "sim":290.0, - "partner":"7b8t" + "partner":"5ens" }, { "sim":290.0, - "partner":"5ens" + "partner":"5en5" }, { "sim":290.0, - "partner":"7oum" + "partner":"6zoa" }, { "sim":290.0, - "partner":"5en5" + "partner":"6zoh" }, { "sim":290.0, @@ -803112,11 +806227,11 @@ }, { "sim":290.0, - "partner":"6zoa" + "partner":"6d65" }, { "sim":290.0, - "partner":"6zoh" + "partner":"6sgr" }, { "sim":290.0, @@ -803132,15 +806247,23 @@ }, { "sim":290.0, - "partner":"6d65" + "partner":"6zob" }, { "sim":290.0, - "partner":"6sgr" + "partner":"4dx5" }, { "sim":290.0, - "partner":"4dx5" + "partner":"5eno" + }, + { + "sim":290.0, + "partner":"6zo5" + }, + { + "sim":290.0, + "partner":"6q4n" }, { "sim":289.0, @@ -803198,10 +806321,6 @@ "sim":274.0, "partner":"6gcu" }, - { - "sim":274.0, - "partner":"8tzb" - }, { "sim":274.0, "partner":"8tzc" @@ -803218,6 +806337,10 @@ "sim":274.0, "partner":"8tzh" }, + { + "sim":274.0, + "partner":"8tzb" + }, { "sim":274.0, "partner":"5lel" @@ -803324,11 +806447,11 @@ }, { "sim":262.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":262.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":262.0, @@ -803376,11 +806499,11 @@ }, { "sim":258.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":258.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":256.0, @@ -803422,10 +806545,6 @@ "sim":247.0, "partner":"6qev" }, - { - "sim":246.0, - "partner":"8g4f" - }, { "sim":246.0, "partner":"8g42" @@ -803442,6 +806561,10 @@ "sim":246.0, "partner":"8g3k" }, + { + "sim":246.0, + "partner":"8g4f" + }, { "sim":246.0, "partner":"6sh9" @@ -803452,11 +806575,11 @@ }, { "sim":244.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":244.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":244.0, @@ -803468,11 +806591,11 @@ }, { "sim":242.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":242.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":240.0, @@ -803578,10 +806701,6 @@ "sim":228.0, "partner":"4hrn" }, - { - "sim":228.0, - "partner":"7pd8" - }, { "sim":228.0, "partner":"7pdd" @@ -803594,6 +806713,10 @@ "sim":228.0, "partner":"7pdh" }, + { + "sim":228.0, + "partner":"7pd8" + }, { "sim":224.0, "partner":"6moj" @@ -803732,23 +806855,23 @@ }, { "sim":119.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":119.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":119.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":119.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":119.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":119.0, @@ -803756,11 +806879,11 @@ }, { "sim":119.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":119.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":119.0, @@ -803834,10 +806957,6 @@ "sim":103.0, "partner":"2l6b" }, - { - "sim":103.0, - "partner":"5vhj" - }, { "sim":103.0, "partner":"5vhh" @@ -803868,15 +806987,15 @@ }, { "sim":103.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":103.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":103.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":103.0, @@ -803886,6 +807005,10 @@ "sim":103.0, "partner":"7vxw" }, + { + "sim":103.0, + "partner":"1uoh" + }, { "sim":103.0, "partner":"7vy4" @@ -803896,11 +807019,11 @@ }, { "sim":103.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":103.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":103.0, @@ -803912,15 +807035,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":102.0, @@ -803960,11 +807083,11 @@ }, { "sim":102.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":102.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":100.0, @@ -803992,11 +807115,11 @@ }, { "sim":99.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":99.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":99.0, @@ -804076,15 +807199,15 @@ }, { "sim":91.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":91.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":91.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":91.0, @@ -804104,16 +807227,24 @@ }, { "sim":90.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":90.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":90.0, "partner":"7roy" }, + { + "sim":90.0, + "partner":"8wqg" + }, + { + "sim":90.0, + "partner":"8wqe" + }, { "sim":90.0, "partner":"8wqh" @@ -804142,14 +807273,6 @@ "sim":90.0, "partner":"8wqd" }, - { - "sim":90.0, - "partner":"8wqg" - }, - { - "sim":90.0, - "partner":"8wqe" - }, { "sim":90.0, "partner":"8je1" @@ -804286,10 +807409,6 @@ "sim":84.0, "partner":"6e2g" }, - { - "sim":84.0, - "partner":"6v9x" - }, { "sim":84.0, "partner":"6v9y" @@ -804302,6 +807421,10 @@ "sim":84.0, "partner":"6v9w" }, + { + "sim":84.0, + "partner":"6v9x" + }, { "sim":84.0, "partner":"7or0" @@ -804422,10 +807545,6 @@ "sim":80.0, "partner":"5wo6" }, - { - "sim":80.0, - "partner":"5iwr" - }, { "sim":80.0, "partner":"5iwt" @@ -804480,11 +807599,11 @@ }, { "sim":80.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":80.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":80.0, @@ -804524,11 +807643,7 @@ }, { "sim":80.0, - "partner":"7t6m" - }, - { - "sim":80.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":80.0, @@ -804564,15 +807679,19 @@ }, { "sim":80.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":80.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":80.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":80.0, + "partner":"7t6k" }, { "sim":80.0, @@ -804580,7 +807699,7 @@ }, { "sim":80.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":80.0, @@ -804588,7 +807707,11 @@ }, { "sim":80.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":80.0, + "partner":"8ffn" }, { "sim":79.0, @@ -804602,14 +807725,6 @@ "sim":79.0, "partner":"6kyk" }, - { - "sim":78.0, - "partner":"3aaa" - }, - { - "sim":78.0, - "partner":"7dsb" - }, { "sim":78.0, "partner":"7df7" @@ -804620,15 +807735,15 @@ }, { "sim":78.0, - "partner":"2he0" + "partner":"7dsb" }, { "sim":78.0, - "partner":"6m11" + "partner":"3aaa" }, { "sim":78.0, - "partner":"6m12" + "partner":"2he0" }, { "sim":78.0, @@ -804654,6 +807769,14 @@ "sim":78.0, "partner":"4o1p" }, + { + "sim":78.0, + "partner":"6m11" + }, + { + "sim":78.0, + "partner":"6m12" + }, { "sim":78.0, "partner":"6aun" @@ -804732,11 +807855,11 @@ }, { "sim":74.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":74.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":74.0, @@ -804762,10 +807885,6 @@ "sim":73.0, "partner":"8sp8" }, - { - "sim":73.0, - "partner":"7k4a" - }, { "sim":73.0, "partner":"7k4b" @@ -804788,7 +807907,7 @@ }, { "sim":73.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":73.0, @@ -804804,7 +807923,7 @@ }, { "sim":73.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":73.0, @@ -804816,7 +807935,7 @@ }, { "sim":73.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":73.0, @@ -804834,6 +807953,10 @@ "sim":73.0, "partner":"6bo8" }, + { + "sim":73.0, + "partner":"6bo9" + }, { "sim":72.0, "partner":"1bi7" @@ -804876,15 +807999,15 @@ }, { "sim":68.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":68.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":68.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":68.0, @@ -805044,19 +808167,19 @@ }, { "sim":50.0, - "partner":"8u43" + "partner":"8u2z" }, { "sim":50.0, - "partner":"8u4d" + "partner":"8u43" }, { "sim":50.0, - "partner":"8u3a" + "partner":"8u4d" }, { "sim":50.0, - "partner":"8u2z" + "partner":"8u3a" }, { "sim":50.0, @@ -805070,18 +808193,10 @@ "sim":50.0, "partner":"5is0" }, - { - "sim":50.0, - "partner":"7mzc" - }, { "sim":50.0, "partner":"7l2v" }, - { - "sim":50.0, - "partner":"8t3l" - }, { "sim":50.0, "partner":"7mzd" @@ -805092,7 +808207,7 @@ }, { "sim":50.0, - "partner":"8t3m" + "partner":"8t3l" }, { "sim":50.0, @@ -805110,6 +808225,10 @@ "sim":50.0, "partner":"7l2x" }, + { + "sim":50.0, + "partner":"8t3m" + }, { "sim":50.0, "partner":"7l2r" @@ -805144,35 +808263,35 @@ }, { "sim":50.0, - "partner":"8t0y" + "partner":"7mzc" }, { "sim":50.0, - "partner":"8u3l" + "partner":"8t0y" }, { "sim":50.0, - "partner":"8t0c" + "partner":"8u30" }, { "sim":50.0, - "partner":"8u30" + "partner":"8u3c" }, { "sim":50.0, - "partner":"8t0e" + "partner":"8t0c" }, { "sim":50.0, - "partner":"8t10" + "partner":"8t0e" }, { "sim":50.0, - "partner":"8u3c" + "partner":"8t10" }, { "sim":50.0, - "partner":"7l2n" + "partner":"8u3l" }, { "sim":50.0, @@ -805208,32 +808327,28 @@ }, { "sim":50.0, - "partner":"7lqy" + "partner":"7l2n" }, { "sim":50.0, - "partner":"7lqz" + "partner":"7lqy" }, { "sim":50.0, - "partner":"7lr0" + "partner":"7lqz" }, { "sim":50.0, - "partner":"7lpd" + "partner":"7lr0" }, { "sim":50.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":50.0, "partner":"7rqv" }, - { - "sim":50.0, - "partner":"7lpe" - }, { "sim":50.0, "partner":"7rqw" @@ -805265,6 +808380,14 @@ { "sim":50.0, "partner":"7lpc" + }, + { + "sim":50.0, + "partner":"7rqu" + }, + { + "sim":50.0, + "partner":"7lpd" } ], "struct_thr_sim_designed":[ @@ -805473,11 +808596,11 @@ ], "seq_max_sim_designed":{ "sim":342.0, - "partner":"8qla" + "partner":"9f8g" }, "seq_max_sim_natural":{ "sim":342.0, - "partner":"7yz0" + "partner":"6mzf" }, "struct_max_sim_designed":{ "sim":1.0, @@ -805597,19 +808720,19 @@ "seq_thr_sim_designed":[ { "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":342.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":342.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":342.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":342.0, @@ -805617,19 +808740,19 @@ }, { "sim":342.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":342.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":342.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":342.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":342.0, @@ -805637,11 +808760,11 @@ }, { "sim":342.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":342.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":298.0, @@ -805657,19 +808780,19 @@ }, { "sim":295.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":295.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":291.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":291.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":290.0, @@ -805725,11 +808848,11 @@ }, { "sim":261.0, - "partner":"7z72" + "partner":"7z7e" }, { "sim":261.0, - "partner":"7z7e" + "partner":"7z72" }, { "sim":259.0, @@ -805797,7 +808920,7 @@ }, { "sim":253.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":253.0, @@ -805805,7 +808928,7 @@ }, { "sim":253.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":252.0, @@ -805861,11 +808984,11 @@ }, { "sim":223.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":223.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":223.0, @@ -805889,11 +809012,11 @@ }, { "sim":207.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":207.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":205.0, @@ -805905,19 +809028,23 @@ }, { "sim":198.0, - "partner":"8rci" + "partner":"7z73" }, { "sim":198.0, - "partner":"7z73" + "partner":"8rci" }, { "sim":192.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":192.0, - "partner":"4qfv" + "partner":"4o60" + }, + { + "sim":187.0, + "partner":"9glq" }, { "sim":178.0, @@ -805965,30 +809092,18 @@ } ], "seq_thr_sim_natural":[ - { - "sim":342.0, - "partner":"7yz0" - }, { "sim":342.0, "partner":"6mzf" }, { "sim":342.0, - "partner":"7yz1" - }, - { - "sim":342.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":342.0, "partner":"5nqt" }, - { - "sim":342.0, - "partner":"6mze" - }, { "sim":342.0, "partner":"7yz2" @@ -805999,11 +809114,11 @@ }, { "sim":342.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":342.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":342.0, @@ -806015,23 +809130,23 @@ }, { "sim":342.0, - "partner":"4lnu" + "partner":"7yz6" }, { "sim":342.0, - "partner":"7yz6" + "partner":"4lnu" }, { "sim":342.0, - "partner":"4drx" + "partner":"6zwb" }, { "sim":342.0, - "partner":"5nm5" + "partner":"4drx" }, { "sim":342.0, - "partner":"6zwb" + "partner":"5nm5" }, { "sim":342.0, @@ -806045,6 +809160,18 @@ "sim":342.0, "partner":"7yyz" }, + { + "sim":342.0, + "partner":"7yz0" + }, + { + "sim":342.0, + "partner":"7yz1" + }, + { + "sim":342.0, + "partner":"7z01" + }, { "sim":338.0, "partner":"6bbn" @@ -806075,11 +809202,11 @@ }, { "sim":315.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":315.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":312.0, @@ -806143,27 +809270,19 @@ }, { "sim":290.0, - "partner":"5eno" - }, - { - "sim":290.0, - "partner":"6zob" - }, - { - "sim":290.0, - "partner":"6zo5" + "partner":"4dx6" }, { "sim":290.0, - "partner":"4dx6" + "partner":"6sgs" }, { "sim":290.0, - "partner":"6q4n" + "partner":"6zoc" }, { "sim":290.0, - "partner":"6zoc" + "partner":"6zo6" }, { "sim":290.0, @@ -806171,11 +809290,11 @@ }, { "sim":290.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":290.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":290.0, @@ -806183,11 +809302,11 @@ }, { "sim":290.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":290.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":290.0, @@ -806195,11 +809314,7 @@ }, { "sim":290.0, - "partner":"6zod" - }, - { - "sim":290.0, - "partner":"7b8r" + "partner":"6zo7" }, { "sim":290.0, @@ -806207,23 +809322,23 @@ }, { "sim":290.0, - "partner":"5enq" + "partner":"6zoe" }, { "sim":290.0, - "partner":"6zo7" + "partner":"5enq" }, { "sim":290.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":290.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":290.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":290.0, @@ -806239,24 +809354,28 @@ }, { "sim":290.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":290.0, - "partner":"3noc" + "partner":"6zof" }, { "sim":290.0, - "partner":"6zo8" + "partner":"3noc" }, { "sim":290.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":290.0, "partner":"5enr" }, + { + "sim":290.0, + "partner":"7oul" + }, { "sim":290.0, "partner":"1svx" @@ -806267,39 +809386,39 @@ }, { "sim":290.0, - "partner":"6sgu" + "partner":"7b8t" }, { "sim":290.0, - "partner":"7oul" + "partner":"6zo9" }, { "sim":290.0, - "partner":"5nc5" + "partner":"6zog" }, { "sim":290.0, - "partner":"6zo9" + "partner":"5nc5" }, { "sim":290.0, - "partner":"6zog" + "partner":"7oum" }, { "sim":290.0, - "partner":"7b8t" + "partner":"5ens" }, { "sim":290.0, - "partner":"5ens" + "partner":"5en5" }, { "sim":290.0, - "partner":"7oum" + "partner":"6zoa" }, { "sim":290.0, - "partner":"5en5" + "partner":"6zoh" }, { "sim":290.0, @@ -806307,11 +809426,11 @@ }, { "sim":290.0, - "partner":"6zoa" + "partner":"6d65" }, { "sim":290.0, - "partner":"6zoh" + "partner":"6sgr" }, { "sim":290.0, @@ -806327,15 +809446,23 @@ }, { "sim":290.0, - "partner":"6d65" + "partner":"6zob" }, { "sim":290.0, - "partner":"6sgr" + "partner":"4dx5" }, { "sim":290.0, - "partner":"4dx5" + "partner":"5eno" + }, + { + "sim":290.0, + "partner":"6zo5" + }, + { + "sim":290.0, + "partner":"6q4n" }, { "sim":289.0, @@ -806393,10 +809520,6 @@ "sim":274.0, "partner":"6gcu" }, - { - "sim":274.0, - "partner":"8tzb" - }, { "sim":274.0, "partner":"8tzc" @@ -806413,6 +809536,10 @@ "sim":274.0, "partner":"8tzh" }, + { + "sim":274.0, + "partner":"8tzb" + }, { "sim":274.0, "partner":"5lel" @@ -806519,11 +809646,11 @@ }, { "sim":262.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":262.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":262.0, @@ -806571,11 +809698,11 @@ }, { "sim":258.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":258.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":256.0, @@ -806617,10 +809744,6 @@ "sim":247.0, "partner":"6qev" }, - { - "sim":246.0, - "partner":"8g4f" - }, { "sim":246.0, "partner":"8g42" @@ -806637,6 +809760,10 @@ "sim":246.0, "partner":"8g3k" }, + { + "sim":246.0, + "partner":"8g4f" + }, { "sim":246.0, "partner":"6sh9" @@ -806647,11 +809774,11 @@ }, { "sim":244.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":244.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":244.0, @@ -806663,11 +809790,11 @@ }, { "sim":242.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":242.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":240.0, @@ -806773,10 +809900,6 @@ "sim":228.0, "partner":"4hrn" }, - { - "sim":228.0, - "partner":"7pd8" - }, { "sim":228.0, "partner":"7pdd" @@ -806789,6 +809912,10 @@ "sim":228.0, "partner":"7pdh" }, + { + "sim":228.0, + "partner":"7pd8" + }, { "sim":224.0, "partner":"6moj" @@ -806927,23 +810054,23 @@ }, { "sim":119.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":119.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":119.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":119.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":119.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":119.0, @@ -806951,11 +810078,11 @@ }, { "sim":119.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":119.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":119.0, @@ -807029,10 +810156,6 @@ "sim":103.0, "partner":"2l6b" }, - { - "sim":103.0, - "partner":"5vhj" - }, { "sim":103.0, "partner":"5vhh" @@ -807063,15 +810186,15 @@ }, { "sim":103.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":103.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":103.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":103.0, @@ -807081,6 +810204,10 @@ "sim":103.0, "partner":"7vxw" }, + { + "sim":103.0, + "partner":"1uoh" + }, { "sim":103.0, "partner":"7vy4" @@ -807091,11 +810218,11 @@ }, { "sim":103.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":103.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":103.0, @@ -807107,15 +810234,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":102.0, @@ -807155,11 +810282,11 @@ }, { "sim":102.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":102.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":100.0, @@ -807187,11 +810314,11 @@ }, { "sim":99.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":99.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":99.0, @@ -807271,15 +810398,15 @@ }, { "sim":91.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":91.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":91.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":91.0, @@ -807299,16 +810426,24 @@ }, { "sim":90.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":90.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":90.0, "partner":"7roy" }, + { + "sim":90.0, + "partner":"8wqg" + }, + { + "sim":90.0, + "partner":"8wqe" + }, { "sim":90.0, "partner":"8wqh" @@ -807337,14 +810472,6 @@ "sim":90.0, "partner":"8wqd" }, - { - "sim":90.0, - "partner":"8wqg" - }, - { - "sim":90.0, - "partner":"8wqe" - }, { "sim":90.0, "partner":"8je1" @@ -807481,10 +810608,6 @@ "sim":84.0, "partner":"6e2g" }, - { - "sim":84.0, - "partner":"6v9x" - }, { "sim":84.0, "partner":"6v9y" @@ -807497,6 +810620,10 @@ "sim":84.0, "partner":"6v9w" }, + { + "sim":84.0, + "partner":"6v9x" + }, { "sim":84.0, "partner":"7or0" @@ -807617,10 +810744,6 @@ "sim":80.0, "partner":"5wo6" }, - { - "sim":80.0, - "partner":"5iwr" - }, { "sim":80.0, "partner":"5iwt" @@ -807675,11 +810798,11 @@ }, { "sim":80.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":80.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":80.0, @@ -807719,11 +810842,7 @@ }, { "sim":80.0, - "partner":"7t6m" - }, - { - "sim":80.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":80.0, @@ -807759,15 +810878,19 @@ }, { "sim":80.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":80.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":80.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":80.0, + "partner":"7t6k" }, { "sim":80.0, @@ -807775,7 +810898,7 @@ }, { "sim":80.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":80.0, @@ -807783,7 +810906,11 @@ }, { "sim":80.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":80.0, + "partner":"8ffn" }, { "sim":79.0, @@ -807797,14 +810924,6 @@ "sim":79.0, "partner":"6kyk" }, - { - "sim":78.0, - "partner":"3aaa" - }, - { - "sim":78.0, - "partner":"7dsb" - }, { "sim":78.0, "partner":"7df7" @@ -807815,15 +810934,15 @@ }, { "sim":78.0, - "partner":"2he0" + "partner":"7dsb" }, { "sim":78.0, - "partner":"6m11" + "partner":"3aaa" }, { "sim":78.0, - "partner":"6m12" + "partner":"2he0" }, { "sim":78.0, @@ -807849,6 +810968,14 @@ "sim":78.0, "partner":"4o1p" }, + { + "sim":78.0, + "partner":"6m11" + }, + { + "sim":78.0, + "partner":"6m12" + }, { "sim":78.0, "partner":"6aun" @@ -807927,11 +811054,11 @@ }, { "sim":74.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":74.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":74.0, @@ -807957,10 +811084,6 @@ "sim":73.0, "partner":"8sp8" }, - { - "sim":73.0, - "partner":"7k4a" - }, { "sim":73.0, "partner":"7k4b" @@ -807983,7 +811106,7 @@ }, { "sim":73.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":73.0, @@ -807999,7 +811122,7 @@ }, { "sim":73.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":73.0, @@ -808011,7 +811134,7 @@ }, { "sim":73.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":73.0, @@ -808029,6 +811152,10 @@ "sim":73.0, "partner":"6bo8" }, + { + "sim":73.0, + "partner":"6bo9" + }, { "sim":72.0, "partner":"1bi7" @@ -808071,15 +811198,15 @@ }, { "sim":68.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":68.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":68.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":68.0, @@ -808239,19 +811366,19 @@ }, { "sim":50.0, - "partner":"8u43" + "partner":"8u2z" }, { "sim":50.0, - "partner":"8u4d" + "partner":"8u43" }, { "sim":50.0, - "partner":"8u3a" + "partner":"8u4d" }, { "sim":50.0, - "partner":"8u2z" + "partner":"8u3a" }, { "sim":50.0, @@ -808265,18 +811392,10 @@ "sim":50.0, "partner":"5is0" }, - { - "sim":50.0, - "partner":"7mzc" - }, { "sim":50.0, "partner":"7l2v" }, - { - "sim":50.0, - "partner":"8t3l" - }, { "sim":50.0, "partner":"7mzd" @@ -808287,7 +811406,7 @@ }, { "sim":50.0, - "partner":"8t3m" + "partner":"8t3l" }, { "sim":50.0, @@ -808305,6 +811424,10 @@ "sim":50.0, "partner":"7l2x" }, + { + "sim":50.0, + "partner":"8t3m" + }, { "sim":50.0, "partner":"7l2r" @@ -808339,35 +811462,35 @@ }, { "sim":50.0, - "partner":"8t0y" + "partner":"7mzc" }, { "sim":50.0, - "partner":"8u3l" + "partner":"8t0y" }, { "sim":50.0, - "partner":"8t0c" + "partner":"8u30" }, { "sim":50.0, - "partner":"8u30" + "partner":"8u3c" }, { "sim":50.0, - "partner":"8t0e" + "partner":"8t0c" }, { "sim":50.0, - "partner":"8t10" + "partner":"8t0e" }, { "sim":50.0, - "partner":"8u3c" + "partner":"8t10" }, { "sim":50.0, - "partner":"7l2n" + "partner":"8u3l" }, { "sim":50.0, @@ -808403,32 +811526,28 @@ }, { "sim":50.0, - "partner":"7lqy" + "partner":"7l2n" }, { "sim":50.0, - "partner":"7lqz" + "partner":"7lqy" }, { "sim":50.0, - "partner":"7lr0" + "partner":"7lqz" }, { "sim":50.0, - "partner":"7lpd" + "partner":"7lr0" }, { "sim":50.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":50.0, "partner":"7rqv" }, - { - "sim":50.0, - "partner":"7lpe" - }, { "sim":50.0, "partner":"7rqw" @@ -808460,6 +811579,14 @@ { "sim":50.0, "partner":"7lpc" + }, + { + "sim":50.0, + "partner":"7rqu" + }, + { + "sim":50.0, + "partner":"7lpd" } ], "struct_thr_sim_designed":[ @@ -808652,11 +811779,11 @@ ], "seq_max_sim_designed":{ "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, "seq_max_sim_natural":{ "sim":342.0, - "partner":"7yz0" + "partner":"6mzf" }, "struct_max_sim_designed":{ "sim":1.0, @@ -808776,19 +811903,19 @@ "seq_thr_sim_designed":[ { "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":342.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":342.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":342.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":342.0, @@ -808796,19 +811923,19 @@ }, { "sim":342.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":342.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":342.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":342.0, - "partner":"8ql4" + "partner":"8ql9" }, { "sim":342.0, @@ -808816,7 +811943,7 @@ }, { "sim":342.0, - "partner":"8qlb" + "partner":"8ql4" }, { "sim":342.0, @@ -808836,19 +811963,19 @@ }, { "sim":295.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":295.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":291.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":291.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":290.0, @@ -808904,11 +812031,11 @@ }, { "sim":261.0, - "partner":"7z72" + "partner":"7z7e" }, { "sim":261.0, - "partner":"7z7e" + "partner":"7z72" }, { "sim":259.0, @@ -808976,7 +812103,7 @@ }, { "sim":253.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":253.0, @@ -808984,7 +812111,7 @@ }, { "sim":253.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":252.0, @@ -809040,11 +812167,11 @@ }, { "sim":223.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":223.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":223.0, @@ -809068,11 +812195,11 @@ }, { "sim":207.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":207.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":205.0, @@ -809084,19 +812211,23 @@ }, { "sim":198.0, - "partner":"8rci" + "partner":"7z73" }, { "sim":198.0, - "partner":"7z73" + "partner":"8rci" }, { "sim":192.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":192.0, - "partner":"4qfv" + "partner":"4o60" + }, + { + "sim":187.0, + "partner":"9glq" }, { "sim":178.0, @@ -809144,30 +812275,18 @@ } ], "seq_thr_sim_natural":[ - { - "sim":342.0, - "partner":"7yz0" - }, { "sim":342.0, "partner":"6mzf" }, { "sim":342.0, - "partner":"7yz1" - }, - { - "sim":342.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":342.0, "partner":"5nqt" }, - { - "sim":342.0, - "partner":"6mze" - }, { "sim":342.0, "partner":"7yz2" @@ -809178,11 +812297,11 @@ }, { "sim":342.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":342.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":342.0, @@ -809194,23 +812313,23 @@ }, { "sim":342.0, - "partner":"4lnu" + "partner":"7yz6" }, { "sim":342.0, - "partner":"7yz6" + "partner":"4lnu" }, { "sim":342.0, - "partner":"4drx" + "partner":"6zwb" }, { "sim":342.0, - "partner":"5nm5" + "partner":"4drx" }, { "sim":342.0, - "partner":"6zwb" + "partner":"5nm5" }, { "sim":342.0, @@ -809224,6 +812343,18 @@ "sim":342.0, "partner":"7yyz" }, + { + "sim":342.0, + "partner":"7yz0" + }, + { + "sim":342.0, + "partner":"7yz1" + }, + { + "sim":342.0, + "partner":"7z01" + }, { "sim":338.0, "partner":"6bbn" @@ -809254,11 +812385,11 @@ }, { "sim":315.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":315.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":312.0, @@ -809322,27 +812453,19 @@ }, { "sim":290.0, - "partner":"5eno" - }, - { - "sim":290.0, - "partner":"6zob" - }, - { - "sim":290.0, - "partner":"6zo5" + "partner":"4dx6" }, { "sim":290.0, - "partner":"4dx6" + "partner":"6sgs" }, { "sim":290.0, - "partner":"6q4n" + "partner":"6zoc" }, { "sim":290.0, - "partner":"6zoc" + "partner":"6zo6" }, { "sim":290.0, @@ -809350,11 +812473,11 @@ }, { "sim":290.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":290.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":290.0, @@ -809362,11 +812485,11 @@ }, { "sim":290.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":290.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":290.0, @@ -809374,11 +812497,7 @@ }, { "sim":290.0, - "partner":"6zod" - }, - { - "sim":290.0, - "partner":"7b8r" + "partner":"6zo7" }, { "sim":290.0, @@ -809386,23 +812505,23 @@ }, { "sim":290.0, - "partner":"5enq" + "partner":"6zoe" }, { "sim":290.0, - "partner":"6zo7" + "partner":"5enq" }, { "sim":290.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":290.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":290.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":290.0, @@ -809418,24 +812537,28 @@ }, { "sim":290.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":290.0, - "partner":"3noc" + "partner":"6zof" }, { "sim":290.0, - "partner":"6zo8" + "partner":"3noc" }, { "sim":290.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":290.0, "partner":"5enr" }, + { + "sim":290.0, + "partner":"7oul" + }, { "sim":290.0, "partner":"1svx" @@ -809446,39 +812569,39 @@ }, { "sim":290.0, - "partner":"6sgu" + "partner":"7b8t" }, { "sim":290.0, - "partner":"7oul" + "partner":"6zo9" }, { "sim":290.0, - "partner":"5nc5" + "partner":"6zog" }, { "sim":290.0, - "partner":"6zo9" + "partner":"5nc5" }, { "sim":290.0, - "partner":"6zog" + "partner":"7oum" }, { "sim":290.0, - "partner":"7b8t" + "partner":"5ens" }, { "sim":290.0, - "partner":"5ens" + "partner":"5en5" }, { "sim":290.0, - "partner":"7oum" + "partner":"6zoa" }, { "sim":290.0, - "partner":"5en5" + "partner":"6zoh" }, { "sim":290.0, @@ -809486,11 +812609,11 @@ }, { "sim":290.0, - "partner":"6zoa" + "partner":"6d65" }, { "sim":290.0, - "partner":"6zoh" + "partner":"6sgr" }, { "sim":290.0, @@ -809506,15 +812629,23 @@ }, { "sim":290.0, - "partner":"6d65" + "partner":"6zob" }, { "sim":290.0, - "partner":"6sgr" + "partner":"4dx5" }, { "sim":290.0, - "partner":"4dx5" + "partner":"5eno" + }, + { + "sim":290.0, + "partner":"6zo5" + }, + { + "sim":290.0, + "partner":"6q4n" }, { "sim":289.0, @@ -809572,10 +812703,6 @@ "sim":274.0, "partner":"6gcu" }, - { - "sim":274.0, - "partner":"8tzb" - }, { "sim":274.0, "partner":"8tzc" @@ -809592,6 +812719,10 @@ "sim":274.0, "partner":"8tzh" }, + { + "sim":274.0, + "partner":"8tzb" + }, { "sim":274.0, "partner":"5lel" @@ -809698,11 +812829,11 @@ }, { "sim":262.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":262.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":262.0, @@ -809750,11 +812881,11 @@ }, { "sim":258.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":258.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":256.0, @@ -809796,10 +812927,6 @@ "sim":247.0, "partner":"6qev" }, - { - "sim":246.0, - "partner":"8g4f" - }, { "sim":246.0, "partner":"8g42" @@ -809816,6 +812943,10 @@ "sim":246.0, "partner":"8g3k" }, + { + "sim":246.0, + "partner":"8g4f" + }, { "sim":246.0, "partner":"6sh9" @@ -809826,11 +812957,11 @@ }, { "sim":244.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":244.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":244.0, @@ -809842,11 +812973,11 @@ }, { "sim":242.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":242.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":240.0, @@ -809952,10 +813083,6 @@ "sim":228.0, "partner":"4hrn" }, - { - "sim":228.0, - "partner":"7pd8" - }, { "sim":228.0, "partner":"7pdd" @@ -809968,6 +813095,10 @@ "sim":228.0, "partner":"7pdh" }, + { + "sim":228.0, + "partner":"7pd8" + }, { "sim":224.0, "partner":"6moj" @@ -810106,23 +813237,23 @@ }, { "sim":119.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":119.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":119.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":119.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":119.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":119.0, @@ -810130,11 +813261,11 @@ }, { "sim":119.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":119.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":119.0, @@ -810208,10 +813339,6 @@ "sim":103.0, "partner":"2l6b" }, - { - "sim":103.0, - "partner":"5vhj" - }, { "sim":103.0, "partner":"5vhh" @@ -810242,15 +813369,15 @@ }, { "sim":103.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":103.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":103.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":103.0, @@ -810260,6 +813387,10 @@ "sim":103.0, "partner":"7vxw" }, + { + "sim":103.0, + "partner":"1uoh" + }, { "sim":103.0, "partner":"7vy4" @@ -810270,11 +813401,11 @@ }, { "sim":103.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":103.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":103.0, @@ -810286,15 +813417,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":102.0, @@ -810334,11 +813465,11 @@ }, { "sim":102.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":102.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":100.0, @@ -810366,11 +813497,11 @@ }, { "sim":99.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":99.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":99.0, @@ -810450,15 +813581,15 @@ }, { "sim":91.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":91.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":91.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":91.0, @@ -810478,16 +813609,24 @@ }, { "sim":90.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":90.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":90.0, "partner":"7roy" }, + { + "sim":90.0, + "partner":"8wqg" + }, + { + "sim":90.0, + "partner":"8wqe" + }, { "sim":90.0, "partner":"8wqh" @@ -810516,14 +813655,6 @@ "sim":90.0, "partner":"8wqd" }, - { - "sim":90.0, - "partner":"8wqg" - }, - { - "sim":90.0, - "partner":"8wqe" - }, { "sim":90.0, "partner":"8je1" @@ -810660,10 +813791,6 @@ "sim":84.0, "partner":"6e2g" }, - { - "sim":84.0, - "partner":"6v9x" - }, { "sim":84.0, "partner":"6v9y" @@ -810676,6 +813803,10 @@ "sim":84.0, "partner":"6v9w" }, + { + "sim":84.0, + "partner":"6v9x" + }, { "sim":84.0, "partner":"7or0" @@ -810796,10 +813927,6 @@ "sim":80.0, "partner":"5wo6" }, - { - "sim":80.0, - "partner":"5iwr" - }, { "sim":80.0, "partner":"5iwt" @@ -810854,11 +813981,11 @@ }, { "sim":80.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":80.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":80.0, @@ -810898,11 +814025,7 @@ }, { "sim":80.0, - "partner":"7t6m" - }, - { - "sim":80.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":80.0, @@ -810938,15 +814061,19 @@ }, { "sim":80.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":80.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":80.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":80.0, + "partner":"7t6k" }, { "sim":80.0, @@ -810954,7 +814081,7 @@ }, { "sim":80.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":80.0, @@ -810962,7 +814089,11 @@ }, { "sim":80.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":80.0, + "partner":"8ffn" }, { "sim":79.0, @@ -810976,14 +814107,6 @@ "sim":79.0, "partner":"6kyk" }, - { - "sim":78.0, - "partner":"3aaa" - }, - { - "sim":78.0, - "partner":"7dsb" - }, { "sim":78.0, "partner":"7df7" @@ -810994,15 +814117,15 @@ }, { "sim":78.0, - "partner":"2he0" + "partner":"7dsb" }, { "sim":78.0, - "partner":"6m11" + "partner":"3aaa" }, { "sim":78.0, - "partner":"6m12" + "partner":"2he0" }, { "sim":78.0, @@ -811028,6 +814151,14 @@ "sim":78.0, "partner":"4o1p" }, + { + "sim":78.0, + "partner":"6m11" + }, + { + "sim":78.0, + "partner":"6m12" + }, { "sim":78.0, "partner":"6aun" @@ -811106,11 +814237,11 @@ }, { "sim":74.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":74.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":74.0, @@ -811136,10 +814267,6 @@ "sim":73.0, "partner":"8sp8" }, - { - "sim":73.0, - "partner":"7k4a" - }, { "sim":73.0, "partner":"7k4b" @@ -811162,7 +814289,7 @@ }, { "sim":73.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":73.0, @@ -811178,7 +814305,7 @@ }, { "sim":73.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":73.0, @@ -811190,7 +814317,7 @@ }, { "sim":73.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":73.0, @@ -811208,6 +814335,10 @@ "sim":73.0, "partner":"6bo8" }, + { + "sim":73.0, + "partner":"6bo9" + }, { "sim":72.0, "partner":"1bi7" @@ -811250,15 +814381,15 @@ }, { "sim":68.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":68.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":68.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":68.0, @@ -811418,19 +814549,19 @@ }, { "sim":50.0, - "partner":"8u43" + "partner":"8u2z" }, { "sim":50.0, - "partner":"8u4d" + "partner":"8u43" }, { "sim":50.0, - "partner":"8u3a" + "partner":"8u4d" }, { "sim":50.0, - "partner":"8u2z" + "partner":"8u3a" }, { "sim":50.0, @@ -811444,18 +814575,10 @@ "sim":50.0, "partner":"5is0" }, - { - "sim":50.0, - "partner":"7mzc" - }, { "sim":50.0, "partner":"7l2v" }, - { - "sim":50.0, - "partner":"8t3l" - }, { "sim":50.0, "partner":"7mzd" @@ -811466,7 +814589,7 @@ }, { "sim":50.0, - "partner":"8t3m" + "partner":"8t3l" }, { "sim":50.0, @@ -811484,6 +814607,10 @@ "sim":50.0, "partner":"7l2x" }, + { + "sim":50.0, + "partner":"8t3m" + }, { "sim":50.0, "partner":"7l2r" @@ -811518,35 +814645,35 @@ }, { "sim":50.0, - "partner":"8t0y" + "partner":"7mzc" }, { "sim":50.0, - "partner":"8u3l" + "partner":"8t0y" }, { "sim":50.0, - "partner":"8t0c" + "partner":"8u30" }, { "sim":50.0, - "partner":"8u30" + "partner":"8u3c" }, { "sim":50.0, - "partner":"8t0e" + "partner":"8t0c" }, { "sim":50.0, - "partner":"8t10" + "partner":"8t0e" }, { "sim":50.0, - "partner":"8u3c" + "partner":"8t10" }, { "sim":50.0, - "partner":"7l2n" + "partner":"8u3l" }, { "sim":50.0, @@ -811582,32 +814709,28 @@ }, { "sim":50.0, - "partner":"7lqy" + "partner":"7l2n" }, { "sim":50.0, - "partner":"7lqz" + "partner":"7lqy" }, { "sim":50.0, - "partner":"7lr0" + "partner":"7lqz" }, { "sim":50.0, - "partner":"7lpd" + "partner":"7lr0" }, { "sim":50.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":50.0, "partner":"7rqv" }, - { - "sim":50.0, - "partner":"7lpe" - }, { "sim":50.0, "partner":"7rqw" @@ -811639,6 +814762,14 @@ { "sim":50.0, "partner":"7lpc" + }, + { + "sim":50.0, + "partner":"7rqu" + }, + { + "sim":50.0, + "partner":"7lpd" } ], "struct_thr_sim_designed":[ @@ -811843,11 +814974,11 @@ ], "seq_max_sim_designed":{ "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, "seq_max_sim_natural":{ "sim":342.0, - "partner":"7yz0" + "partner":"6mzf" }, "struct_max_sim_designed":{ "sim":1.0, @@ -811967,19 +815098,15 @@ "seq_thr_sim_designed":[ { "sim":342.0, - "partner":"8qla" - }, - { - "sim":342.0, - "partner":"8qea" + "partner":"8ql3" }, { "sim":342.0, - "partner":"4dui" + "partner":"9f8g" }, { "sim":342.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":342.0, @@ -811987,19 +815114,19 @@ }, { "sim":342.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":342.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":342.0, - "partner":"8ql5" + "partner":"8qlb" }, { "sim":342.0, - "partner":"8ql4" + "partner":"8ql9" }, { "sim":342.0, @@ -812007,12 +815134,16 @@ }, { "sim":342.0, - "partner":"8qlb" + "partner":"8ql4" }, { "sim":342.0, "partner":"8ql2" }, + { + "sim":342.0, + "partner":"8ql5" + }, { "sim":298.0, "partner":"7dnf" @@ -812027,19 +815158,19 @@ }, { "sim":295.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":295.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":291.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":291.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":290.0, @@ -812095,11 +815226,11 @@ }, { "sim":261.0, - "partner":"7z72" + "partner":"7z7e" }, { "sim":261.0, - "partner":"7z7e" + "partner":"7z72" }, { "sim":259.0, @@ -812167,7 +815298,7 @@ }, { "sim":253.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":253.0, @@ -812175,7 +815306,7 @@ }, { "sim":253.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":252.0, @@ -812231,11 +815362,11 @@ }, { "sim":223.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":223.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":223.0, @@ -812259,11 +815390,11 @@ }, { "sim":207.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":207.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":205.0, @@ -812275,19 +815406,23 @@ }, { "sim":198.0, - "partner":"8rci" + "partner":"7z73" }, { "sim":198.0, - "partner":"7z73" + "partner":"8rci" }, { "sim":192.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":192.0, - "partner":"4qfv" + "partner":"4o60" + }, + { + "sim":187.0, + "partner":"9glq" }, { "sim":178.0, @@ -812335,30 +815470,18 @@ } ], "seq_thr_sim_natural":[ - { - "sim":342.0, - "partner":"7yz0" - }, { "sim":342.0, "partner":"6mzf" }, { "sim":342.0, - "partner":"7yz1" - }, - { - "sim":342.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":342.0, "partner":"5nqt" }, - { - "sim":342.0, - "partner":"6mze" - }, { "sim":342.0, "partner":"7yz2" @@ -812369,11 +815492,11 @@ }, { "sim":342.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":342.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":342.0, @@ -812385,23 +815508,23 @@ }, { "sim":342.0, - "partner":"4lnu" + "partner":"7yz6" }, { "sim":342.0, - "partner":"7yz6" + "partner":"4lnu" }, { "sim":342.0, - "partner":"4drx" + "partner":"6zwb" }, { "sim":342.0, - "partner":"5nm5" + "partner":"4drx" }, { "sim":342.0, - "partner":"6zwb" + "partner":"5nm5" }, { "sim":342.0, @@ -812415,6 +815538,18 @@ "sim":342.0, "partner":"7yyz" }, + { + "sim":342.0, + "partner":"7yz0" + }, + { + "sim":342.0, + "partner":"7yz1" + }, + { + "sim":342.0, + "partner":"7z01" + }, { "sim":338.0, "partner":"6bbn" @@ -812445,11 +815580,11 @@ }, { "sim":315.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":315.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":312.0, @@ -812513,27 +815648,19 @@ }, { "sim":290.0, - "partner":"5eno" - }, - { - "sim":290.0, - "partner":"6zob" - }, - { - "sim":290.0, - "partner":"6zo5" + "partner":"4dx6" }, { "sim":290.0, - "partner":"4dx6" + "partner":"6sgs" }, { "sim":290.0, - "partner":"6q4n" + "partner":"6zoc" }, { "sim":290.0, - "partner":"6zoc" + "partner":"6zo6" }, { "sim":290.0, @@ -812541,11 +815668,11 @@ }, { "sim":290.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":290.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":290.0, @@ -812553,11 +815680,11 @@ }, { "sim":290.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":290.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":290.0, @@ -812565,11 +815692,7 @@ }, { "sim":290.0, - "partner":"6zod" - }, - { - "sim":290.0, - "partner":"7b8r" + "partner":"6zo7" }, { "sim":290.0, @@ -812577,23 +815700,23 @@ }, { "sim":290.0, - "partner":"5enq" + "partner":"6zoe" }, { "sim":290.0, - "partner":"6zo7" + "partner":"5enq" }, { "sim":290.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":290.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":290.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":290.0, @@ -812609,24 +815732,28 @@ }, { "sim":290.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":290.0, - "partner":"3noc" + "partner":"6zof" }, { "sim":290.0, - "partner":"6zo8" + "partner":"3noc" }, { "sim":290.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":290.0, "partner":"5enr" }, + { + "sim":290.0, + "partner":"7oul" + }, { "sim":290.0, "partner":"1svx" @@ -812637,39 +815764,39 @@ }, { "sim":290.0, - "partner":"6sgu" + "partner":"7b8t" }, { "sim":290.0, - "partner":"7oul" + "partner":"6zo9" }, { "sim":290.0, - "partner":"5nc5" + "partner":"6zog" }, { "sim":290.0, - "partner":"6zo9" + "partner":"5nc5" }, { "sim":290.0, - "partner":"6zog" + "partner":"7oum" }, { "sim":290.0, - "partner":"7b8t" + "partner":"5ens" }, { "sim":290.0, - "partner":"5ens" + "partner":"5en5" }, { "sim":290.0, - "partner":"7oum" + "partner":"6zoa" }, { "sim":290.0, - "partner":"5en5" + "partner":"6zoh" }, { "sim":290.0, @@ -812677,11 +815804,11 @@ }, { "sim":290.0, - "partner":"6zoa" + "partner":"6d65" }, { "sim":290.0, - "partner":"6zoh" + "partner":"6sgr" }, { "sim":290.0, @@ -812697,15 +815824,23 @@ }, { "sim":290.0, - "partner":"6d65" + "partner":"6zob" }, { "sim":290.0, - "partner":"6sgr" + "partner":"4dx5" }, { "sim":290.0, - "partner":"4dx5" + "partner":"5eno" + }, + { + "sim":290.0, + "partner":"6zo5" + }, + { + "sim":290.0, + "partner":"6q4n" }, { "sim":289.0, @@ -812763,10 +815898,6 @@ "sim":274.0, "partner":"6gcu" }, - { - "sim":274.0, - "partner":"8tzb" - }, { "sim":274.0, "partner":"8tzc" @@ -812783,6 +815914,10 @@ "sim":274.0, "partner":"8tzh" }, + { + "sim":274.0, + "partner":"8tzb" + }, { "sim":274.0, "partner":"5lel" @@ -812889,11 +816024,11 @@ }, { "sim":262.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":262.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":262.0, @@ -812941,11 +816076,11 @@ }, { "sim":258.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":258.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":256.0, @@ -812987,10 +816122,6 @@ "sim":247.0, "partner":"6qev" }, - { - "sim":246.0, - "partner":"8g4f" - }, { "sim":246.0, "partner":"8g42" @@ -813007,6 +816138,10 @@ "sim":246.0, "partner":"8g3k" }, + { + "sim":246.0, + "partner":"8g4f" + }, { "sim":246.0, "partner":"6sh9" @@ -813017,11 +816152,11 @@ }, { "sim":244.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":244.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":244.0, @@ -813033,11 +816168,11 @@ }, { "sim":242.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":242.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":240.0, @@ -813143,10 +816278,6 @@ "sim":228.0, "partner":"4hrn" }, - { - "sim":228.0, - "partner":"7pd8" - }, { "sim":228.0, "partner":"7pdd" @@ -813159,6 +816290,10 @@ "sim":228.0, "partner":"7pdh" }, + { + "sim":228.0, + "partner":"7pd8" + }, { "sim":224.0, "partner":"6moj" @@ -813297,23 +816432,23 @@ }, { "sim":119.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":119.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":119.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":119.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":119.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":119.0, @@ -813321,11 +816456,11 @@ }, { "sim":119.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":119.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":119.0, @@ -813399,10 +816534,6 @@ "sim":103.0, "partner":"2l6b" }, - { - "sim":103.0, - "partner":"5vhj" - }, { "sim":103.0, "partner":"5vhh" @@ -813433,15 +816564,15 @@ }, { "sim":103.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":103.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":103.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":103.0, @@ -813451,6 +816582,10 @@ "sim":103.0, "partner":"7vxw" }, + { + "sim":103.0, + "partner":"1uoh" + }, { "sim":103.0, "partner":"7vy4" @@ -813461,11 +816596,11 @@ }, { "sim":103.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":103.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":103.0, @@ -813477,15 +816612,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":102.0, @@ -813525,11 +816660,11 @@ }, { "sim":102.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":102.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":100.0, @@ -813557,11 +816692,11 @@ }, { "sim":99.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":99.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":99.0, @@ -813641,15 +816776,15 @@ }, { "sim":91.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":91.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":91.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":91.0, @@ -813669,16 +816804,24 @@ }, { "sim":90.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":90.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":90.0, "partner":"7roy" }, + { + "sim":90.0, + "partner":"8wqg" + }, + { + "sim":90.0, + "partner":"8wqe" + }, { "sim":90.0, "partner":"8wqh" @@ -813707,14 +816850,6 @@ "sim":90.0, "partner":"8wqd" }, - { - "sim":90.0, - "partner":"8wqg" - }, - { - "sim":90.0, - "partner":"8wqe" - }, { "sim":90.0, "partner":"8je1" @@ -813851,10 +816986,6 @@ "sim":84.0, "partner":"6e2g" }, - { - "sim":84.0, - "partner":"6v9x" - }, { "sim":84.0, "partner":"6v9y" @@ -813867,6 +816998,10 @@ "sim":84.0, "partner":"6v9w" }, + { + "sim":84.0, + "partner":"6v9x" + }, { "sim":84.0, "partner":"7or0" @@ -813987,10 +817122,6 @@ "sim":80.0, "partner":"5wo6" }, - { - "sim":80.0, - "partner":"5iwr" - }, { "sim":80.0, "partner":"5iwt" @@ -814045,11 +817176,11 @@ }, { "sim":80.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":80.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":80.0, @@ -814089,11 +817220,7 @@ }, { "sim":80.0, - "partner":"7t6m" - }, - { - "sim":80.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":80.0, @@ -814129,15 +817256,19 @@ }, { "sim":80.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":80.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":80.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":80.0, + "partner":"7t6k" }, { "sim":80.0, @@ -814145,7 +817276,7 @@ }, { "sim":80.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":80.0, @@ -814153,7 +817284,11 @@ }, { "sim":80.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":80.0, + "partner":"8ffn" }, { "sim":79.0, @@ -814167,14 +817302,6 @@ "sim":79.0, "partner":"6kyk" }, - { - "sim":78.0, - "partner":"3aaa" - }, - { - "sim":78.0, - "partner":"7dsb" - }, { "sim":78.0, "partner":"7df7" @@ -814185,15 +817312,15 @@ }, { "sim":78.0, - "partner":"2he0" + "partner":"7dsb" }, { "sim":78.0, - "partner":"6m11" + "partner":"3aaa" }, { "sim":78.0, - "partner":"6m12" + "partner":"2he0" }, { "sim":78.0, @@ -814219,6 +817346,14 @@ "sim":78.0, "partner":"4o1p" }, + { + "sim":78.0, + "partner":"6m11" + }, + { + "sim":78.0, + "partner":"6m12" + }, { "sim":78.0, "partner":"6aun" @@ -814297,11 +817432,11 @@ }, { "sim":74.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":74.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":74.0, @@ -814327,10 +817462,6 @@ "sim":73.0, "partner":"8sp8" }, - { - "sim":73.0, - "partner":"7k4a" - }, { "sim":73.0, "partner":"7k4b" @@ -814353,7 +817484,7 @@ }, { "sim":73.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":73.0, @@ -814369,7 +817500,7 @@ }, { "sim":73.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":73.0, @@ -814381,7 +817512,7 @@ }, { "sim":73.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":73.0, @@ -814399,6 +817530,10 @@ "sim":73.0, "partner":"6bo8" }, + { + "sim":73.0, + "partner":"6bo9" + }, { "sim":72.0, "partner":"1bi7" @@ -814441,15 +817576,15 @@ }, { "sim":68.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":68.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":68.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":68.0, @@ -814609,19 +817744,19 @@ }, { "sim":50.0, - "partner":"8u43" + "partner":"8u2z" }, { "sim":50.0, - "partner":"8u4d" + "partner":"8u43" }, { "sim":50.0, - "partner":"8u3a" + "partner":"8u4d" }, { "sim":50.0, - "partner":"8u2z" + "partner":"8u3a" }, { "sim":50.0, @@ -814635,18 +817770,10 @@ "sim":50.0, "partner":"5is0" }, - { - "sim":50.0, - "partner":"7mzc" - }, { "sim":50.0, "partner":"7l2v" }, - { - "sim":50.0, - "partner":"8t3l" - }, { "sim":50.0, "partner":"7mzd" @@ -814657,7 +817784,7 @@ }, { "sim":50.0, - "partner":"8t3m" + "partner":"8t3l" }, { "sim":50.0, @@ -814675,6 +817802,10 @@ "sim":50.0, "partner":"7l2x" }, + { + "sim":50.0, + "partner":"8t3m" + }, { "sim":50.0, "partner":"7l2r" @@ -814709,35 +817840,35 @@ }, { "sim":50.0, - "partner":"8t0y" + "partner":"7mzc" }, { "sim":50.0, - "partner":"8u3l" + "partner":"8t0y" }, { "sim":50.0, - "partner":"8t0c" + "partner":"8u30" }, { "sim":50.0, - "partner":"8u30" + "partner":"8u3c" }, { "sim":50.0, - "partner":"8t0e" + "partner":"8t0c" }, { "sim":50.0, - "partner":"8t10" + "partner":"8t0e" }, { "sim":50.0, - "partner":"8u3c" + "partner":"8t10" }, { "sim":50.0, - "partner":"7l2n" + "partner":"8u3l" }, { "sim":50.0, @@ -814773,32 +817904,28 @@ }, { "sim":50.0, - "partner":"7lqy" + "partner":"7l2n" }, { "sim":50.0, - "partner":"7lqz" + "partner":"7lqy" }, { "sim":50.0, - "partner":"7lr0" + "partner":"7lqz" }, { "sim":50.0, - "partner":"7lpd" + "partner":"7lr0" }, { "sim":50.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":50.0, "partner":"7rqv" }, - { - "sim":50.0, - "partner":"7lpe" - }, { "sim":50.0, "partner":"7rqw" @@ -814830,6 +817957,14 @@ { "sim":50.0, "partner":"7lpc" + }, + { + "sim":50.0, + "partner":"7rqu" + }, + { + "sim":50.0, + "partner":"7lpd" } ], "struct_thr_sim_designed":[ @@ -815066,11 +818201,11 @@ ], "seq_max_sim_designed":{ "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, "seq_max_sim_natural":{ "sim":342.0, - "partner":"7yz0" + "partner":"6mzf" }, "struct_max_sim_designed":{ "sim":1.0, @@ -815190,19 +818325,19 @@ "seq_thr_sim_designed":[ { "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":342.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":342.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":342.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":342.0, @@ -815210,19 +818345,19 @@ }, { "sim":342.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":342.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":342.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":342.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":342.0, @@ -815230,11 +818365,11 @@ }, { "sim":342.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":342.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":298.0, @@ -815250,19 +818385,19 @@ }, { "sim":295.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":295.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":291.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":291.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":290.0, @@ -815318,11 +818453,11 @@ }, { "sim":261.0, - "partner":"7z72" + "partner":"7z7e" }, { "sim":261.0, - "partner":"7z7e" + "partner":"7z72" }, { "sim":259.0, @@ -815390,7 +818525,7 @@ }, { "sim":253.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":253.0, @@ -815398,7 +818533,7 @@ }, { "sim":253.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":252.0, @@ -815454,11 +818589,11 @@ }, { "sim":223.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":223.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":223.0, @@ -815482,11 +818617,11 @@ }, { "sim":207.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":207.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":205.0, @@ -815498,19 +818633,23 @@ }, { "sim":198.0, - "partner":"8rci" + "partner":"7z73" }, { "sim":198.0, - "partner":"7z73" + "partner":"8rci" }, { "sim":192.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":192.0, - "partner":"4qfv" + "partner":"4o60" + }, + { + "sim":187.0, + "partner":"9glq" }, { "sim":178.0, @@ -815558,30 +818697,18 @@ } ], "seq_thr_sim_natural":[ - { - "sim":342.0, - "partner":"7yz0" - }, { "sim":342.0, "partner":"6mzf" }, { "sim":342.0, - "partner":"7yz1" - }, - { - "sim":342.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":342.0, "partner":"5nqt" }, - { - "sim":342.0, - "partner":"6mze" - }, { "sim":342.0, "partner":"7yz2" @@ -815592,11 +818719,11 @@ }, { "sim":342.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":342.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":342.0, @@ -815608,23 +818735,23 @@ }, { "sim":342.0, - "partner":"4lnu" + "partner":"7yz6" }, { "sim":342.0, - "partner":"7yz6" + "partner":"4lnu" }, { "sim":342.0, - "partner":"4drx" + "partner":"6zwb" }, { "sim":342.0, - "partner":"5nm5" + "partner":"4drx" }, { "sim":342.0, - "partner":"6zwb" + "partner":"5nm5" }, { "sim":342.0, @@ -815638,6 +818765,18 @@ "sim":342.0, "partner":"7yyz" }, + { + "sim":342.0, + "partner":"7yz0" + }, + { + "sim":342.0, + "partner":"7yz1" + }, + { + "sim":342.0, + "partner":"7z01" + }, { "sim":338.0, "partner":"6bbn" @@ -815668,11 +818807,11 @@ }, { "sim":315.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":315.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":312.0, @@ -815736,27 +818875,19 @@ }, { "sim":290.0, - "partner":"5eno" - }, - { - "sim":290.0, - "partner":"6zob" - }, - { - "sim":290.0, - "partner":"6zo5" + "partner":"4dx6" }, { "sim":290.0, - "partner":"4dx6" + "partner":"6sgs" }, { "sim":290.0, - "partner":"6q4n" + "partner":"6zoc" }, { "sim":290.0, - "partner":"6zoc" + "partner":"6zo6" }, { "sim":290.0, @@ -815764,11 +818895,11 @@ }, { "sim":290.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":290.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":290.0, @@ -815776,11 +818907,11 @@ }, { "sim":290.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":290.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":290.0, @@ -815788,11 +818919,7 @@ }, { "sim":290.0, - "partner":"6zod" - }, - { - "sim":290.0, - "partner":"7b8r" + "partner":"6zo7" }, { "sim":290.0, @@ -815800,23 +818927,23 @@ }, { "sim":290.0, - "partner":"5enq" + "partner":"6zoe" }, { "sim":290.0, - "partner":"6zo7" + "partner":"5enq" }, { "sim":290.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":290.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":290.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":290.0, @@ -815832,24 +818959,28 @@ }, { "sim":290.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":290.0, - "partner":"3noc" + "partner":"6zof" }, { "sim":290.0, - "partner":"6zo8" + "partner":"3noc" }, { "sim":290.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":290.0, "partner":"5enr" }, + { + "sim":290.0, + "partner":"7oul" + }, { "sim":290.0, "partner":"1svx" @@ -815860,39 +818991,39 @@ }, { "sim":290.0, - "partner":"6sgu" + "partner":"7b8t" }, { "sim":290.0, - "partner":"7oul" + "partner":"6zo9" }, { "sim":290.0, - "partner":"5nc5" + "partner":"6zog" }, { "sim":290.0, - "partner":"6zo9" + "partner":"5nc5" }, { "sim":290.0, - "partner":"6zog" + "partner":"7oum" }, { "sim":290.0, - "partner":"7b8t" + "partner":"5ens" }, { "sim":290.0, - "partner":"5ens" + "partner":"5en5" }, { "sim":290.0, - "partner":"7oum" + "partner":"6zoa" }, { "sim":290.0, - "partner":"5en5" + "partner":"6zoh" }, { "sim":290.0, @@ -815900,11 +819031,11 @@ }, { "sim":290.0, - "partner":"6zoa" + "partner":"6d65" }, { "sim":290.0, - "partner":"6zoh" + "partner":"6sgr" }, { "sim":290.0, @@ -815920,15 +819051,23 @@ }, { "sim":290.0, - "partner":"6d65" + "partner":"6zob" }, { "sim":290.0, - "partner":"6sgr" + "partner":"4dx5" }, { "sim":290.0, - "partner":"4dx5" + "partner":"5eno" + }, + { + "sim":290.0, + "partner":"6zo5" + }, + { + "sim":290.0, + "partner":"6q4n" }, { "sim":289.0, @@ -815986,10 +819125,6 @@ "sim":274.0, "partner":"6gcu" }, - { - "sim":274.0, - "partner":"8tzb" - }, { "sim":274.0, "partner":"8tzc" @@ -816006,6 +819141,10 @@ "sim":274.0, "partner":"8tzh" }, + { + "sim":274.0, + "partner":"8tzb" + }, { "sim":274.0, "partner":"5lel" @@ -816112,11 +819251,11 @@ }, { "sim":262.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":262.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":262.0, @@ -816164,11 +819303,11 @@ }, { "sim":258.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":258.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":256.0, @@ -816210,10 +819349,6 @@ "sim":247.0, "partner":"6qev" }, - { - "sim":246.0, - "partner":"8g4f" - }, { "sim":246.0, "partner":"8g42" @@ -816230,6 +819365,10 @@ "sim":246.0, "partner":"8g3k" }, + { + "sim":246.0, + "partner":"8g4f" + }, { "sim":246.0, "partner":"6sh9" @@ -816240,11 +819379,11 @@ }, { "sim":244.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":244.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":244.0, @@ -816256,11 +819395,11 @@ }, { "sim":242.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":242.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":240.0, @@ -816366,10 +819505,6 @@ "sim":228.0, "partner":"4hrn" }, - { - "sim":228.0, - "partner":"7pd8" - }, { "sim":228.0, "partner":"7pdd" @@ -816382,6 +819517,10 @@ "sim":228.0, "partner":"7pdh" }, + { + "sim":228.0, + "partner":"7pd8" + }, { "sim":224.0, "partner":"6moj" @@ -816520,23 +819659,23 @@ }, { "sim":119.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":119.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":119.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":119.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":119.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":119.0, @@ -816544,11 +819683,11 @@ }, { "sim":119.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":119.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":119.0, @@ -816622,10 +819761,6 @@ "sim":103.0, "partner":"2l6b" }, - { - "sim":103.0, - "partner":"5vhj" - }, { "sim":103.0, "partner":"5vhh" @@ -816656,15 +819791,15 @@ }, { "sim":103.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":103.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":103.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":103.0, @@ -816674,6 +819809,10 @@ "sim":103.0, "partner":"7vxw" }, + { + "sim":103.0, + "partner":"1uoh" + }, { "sim":103.0, "partner":"7vy4" @@ -816684,11 +819823,11 @@ }, { "sim":103.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":103.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":103.0, @@ -816700,15 +819839,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":102.0, @@ -816748,11 +819887,11 @@ }, { "sim":102.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":102.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":100.0, @@ -816780,11 +819919,11 @@ }, { "sim":99.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":99.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":99.0, @@ -816864,15 +820003,15 @@ }, { "sim":91.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":91.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":91.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":91.0, @@ -816892,16 +820031,24 @@ }, { "sim":90.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":90.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":90.0, "partner":"7roy" }, + { + "sim":90.0, + "partner":"8wqg" + }, + { + "sim":90.0, + "partner":"8wqe" + }, { "sim":90.0, "partner":"8wqh" @@ -816930,14 +820077,6 @@ "sim":90.0, "partner":"8wqd" }, - { - "sim":90.0, - "partner":"8wqg" - }, - { - "sim":90.0, - "partner":"8wqe" - }, { "sim":90.0, "partner":"8je1" @@ -817074,10 +820213,6 @@ "sim":84.0, "partner":"6e2g" }, - { - "sim":84.0, - "partner":"6v9x" - }, { "sim":84.0, "partner":"6v9y" @@ -817090,6 +820225,10 @@ "sim":84.0, "partner":"6v9w" }, + { + "sim":84.0, + "partner":"6v9x" + }, { "sim":84.0, "partner":"7or0" @@ -817210,10 +820349,6 @@ "sim":80.0, "partner":"5wo6" }, - { - "sim":80.0, - "partner":"5iwr" - }, { "sim":80.0, "partner":"5iwt" @@ -817268,11 +820403,11 @@ }, { "sim":80.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":80.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":80.0, @@ -817312,11 +820447,7 @@ }, { "sim":80.0, - "partner":"7t6m" - }, - { - "sim":80.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":80.0, @@ -817352,15 +820483,19 @@ }, { "sim":80.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":80.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":80.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":80.0, + "partner":"7t6k" }, { "sim":80.0, @@ -817368,7 +820503,7 @@ }, { "sim":80.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":80.0, @@ -817376,7 +820511,11 @@ }, { "sim":80.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":80.0, + "partner":"8ffn" }, { "sim":79.0, @@ -817390,14 +820529,6 @@ "sim":79.0, "partner":"6kyk" }, - { - "sim":78.0, - "partner":"3aaa" - }, - { - "sim":78.0, - "partner":"7dsb" - }, { "sim":78.0, "partner":"7df7" @@ -817408,15 +820539,15 @@ }, { "sim":78.0, - "partner":"2he0" + "partner":"7dsb" }, { "sim":78.0, - "partner":"6m11" + "partner":"3aaa" }, { "sim":78.0, - "partner":"6m12" + "partner":"2he0" }, { "sim":78.0, @@ -817442,6 +820573,14 @@ "sim":78.0, "partner":"4o1p" }, + { + "sim":78.0, + "partner":"6m11" + }, + { + "sim":78.0, + "partner":"6m12" + }, { "sim":78.0, "partner":"6aun" @@ -817520,11 +820659,11 @@ }, { "sim":74.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":74.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":74.0, @@ -817550,10 +820689,6 @@ "sim":73.0, "partner":"8sp8" }, - { - "sim":73.0, - "partner":"7k4a" - }, { "sim":73.0, "partner":"7k4b" @@ -817576,7 +820711,7 @@ }, { "sim":73.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":73.0, @@ -817592,7 +820727,7 @@ }, { "sim":73.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":73.0, @@ -817604,7 +820739,7 @@ }, { "sim":73.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":73.0, @@ -817622,6 +820757,10 @@ "sim":73.0, "partner":"6bo8" }, + { + "sim":73.0, + "partner":"6bo9" + }, { "sim":72.0, "partner":"1bi7" @@ -817664,15 +820803,15 @@ }, { "sim":68.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":68.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":68.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":68.0, @@ -817832,19 +820971,19 @@ }, { "sim":50.0, - "partner":"8u43" + "partner":"8u2z" }, { "sim":50.0, - "partner":"8u4d" + "partner":"8u43" }, { "sim":50.0, - "partner":"8u3a" + "partner":"8u4d" }, { "sim":50.0, - "partner":"8u2z" + "partner":"8u3a" }, { "sim":50.0, @@ -817858,18 +820997,10 @@ "sim":50.0, "partner":"5is0" }, - { - "sim":50.0, - "partner":"7mzc" - }, { "sim":50.0, "partner":"7l2v" }, - { - "sim":50.0, - "partner":"8t3l" - }, { "sim":50.0, "partner":"7mzd" @@ -817880,7 +821011,7 @@ }, { "sim":50.0, - "partner":"8t3m" + "partner":"8t3l" }, { "sim":50.0, @@ -817898,6 +821029,10 @@ "sim":50.0, "partner":"7l2x" }, + { + "sim":50.0, + "partner":"8t3m" + }, { "sim":50.0, "partner":"7l2r" @@ -817932,35 +821067,35 @@ }, { "sim":50.0, - "partner":"8t0y" + "partner":"7mzc" }, { "sim":50.0, - "partner":"8u3l" + "partner":"8t0y" }, { "sim":50.0, - "partner":"8t0c" + "partner":"8u30" }, { "sim":50.0, - "partner":"8u30" + "partner":"8u3c" }, { "sim":50.0, - "partner":"8t0e" + "partner":"8t0c" }, { "sim":50.0, - "partner":"8t10" + "partner":"8t0e" }, { "sim":50.0, - "partner":"8u3c" + "partner":"8t10" }, { "sim":50.0, - "partner":"7l2n" + "partner":"8u3l" }, { "sim":50.0, @@ -817996,32 +821131,28 @@ }, { "sim":50.0, - "partner":"7lqy" + "partner":"7l2n" }, { "sim":50.0, - "partner":"7lqz" + "partner":"7lqy" }, { "sim":50.0, - "partner":"7lr0" + "partner":"7lqz" }, { "sim":50.0, - "partner":"7lpd" + "partner":"7lr0" }, { "sim":50.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":50.0, "partner":"7rqv" }, - { - "sim":50.0, - "partner":"7lpe" - }, { "sim":50.0, "partner":"7rqw" @@ -818053,6 +821184,14 @@ { "sim":50.0, "partner":"7lpc" + }, + { + "sim":50.0, + "partner":"7rqu" + }, + { + "sim":50.0, + "partner":"7lpd" } ], "struct_thr_sim_designed":[ @@ -818289,11 +821428,11 @@ ], "seq_max_sim_designed":{ "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, "seq_max_sim_natural":{ "sim":342.0, - "partner":"7yz0" + "partner":"6mzf" }, "struct_max_sim_designed":{ "sim":1.0, @@ -818413,51 +821552,51 @@ "seq_thr_sim_designed":[ { "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":342.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":342.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":342.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":342.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":342.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":342.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":342.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":342.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":342.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":342.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":342.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":298.0, @@ -818473,19 +821612,19 @@ }, { "sim":295.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":295.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":291.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":291.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":290.0, @@ -818541,11 +821680,11 @@ }, { "sim":261.0, - "partner":"7z72" + "partner":"7z7e" }, { "sim":261.0, - "partner":"7z7e" + "partner":"7z72" }, { "sim":259.0, @@ -818613,7 +821752,7 @@ }, { "sim":253.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":253.0, @@ -818621,7 +821760,7 @@ }, { "sim":253.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":252.0, @@ -818677,11 +821816,11 @@ }, { "sim":223.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":223.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":223.0, @@ -818705,11 +821844,11 @@ }, { "sim":207.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":207.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":205.0, @@ -818721,19 +821860,23 @@ }, { "sim":198.0, - "partner":"8rci" + "partner":"7z73" }, { "sim":198.0, - "partner":"7z73" + "partner":"8rci" }, { "sim":192.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":192.0, - "partner":"4qfv" + "partner":"4o60" + }, + { + "sim":187.0, + "partner":"9glq" }, { "sim":178.0, @@ -818781,30 +821924,18 @@ } ], "seq_thr_sim_natural":[ - { - "sim":342.0, - "partner":"7yz0" - }, { "sim":342.0, "partner":"6mzf" }, { "sim":342.0, - "partner":"7yz1" - }, - { - "sim":342.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":342.0, "partner":"5nqt" }, - { - "sim":342.0, - "partner":"6mze" - }, { "sim":342.0, "partner":"7yz2" @@ -818815,11 +821946,11 @@ }, { "sim":342.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":342.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":342.0, @@ -818831,23 +821962,23 @@ }, { "sim":342.0, - "partner":"4lnu" + "partner":"7yz6" }, { "sim":342.0, - "partner":"7yz6" + "partner":"4lnu" }, { "sim":342.0, - "partner":"4drx" + "partner":"6zwb" }, { "sim":342.0, - "partner":"5nm5" + "partner":"4drx" }, { "sim":342.0, - "partner":"6zwb" + "partner":"5nm5" }, { "sim":342.0, @@ -818861,6 +821992,18 @@ "sim":342.0, "partner":"7yyz" }, + { + "sim":342.0, + "partner":"7yz0" + }, + { + "sim":342.0, + "partner":"7yz1" + }, + { + "sim":342.0, + "partner":"7z01" + }, { "sim":338.0, "partner":"6bbn" @@ -818891,11 +822034,11 @@ }, { "sim":315.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":315.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":312.0, @@ -818959,27 +822102,19 @@ }, { "sim":290.0, - "partner":"5eno" - }, - { - "sim":290.0, - "partner":"6zob" - }, - { - "sim":290.0, - "partner":"6zo5" + "partner":"4dx6" }, { "sim":290.0, - "partner":"4dx6" + "partner":"6sgs" }, { "sim":290.0, - "partner":"6q4n" + "partner":"6zoc" }, { "sim":290.0, - "partner":"6zoc" + "partner":"6zo6" }, { "sim":290.0, @@ -818987,11 +822122,11 @@ }, { "sim":290.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":290.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":290.0, @@ -818999,11 +822134,11 @@ }, { "sim":290.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":290.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":290.0, @@ -819011,11 +822146,7 @@ }, { "sim":290.0, - "partner":"6zod" - }, - { - "sim":290.0, - "partner":"7b8r" + "partner":"6zo7" }, { "sim":290.0, @@ -819023,23 +822154,23 @@ }, { "sim":290.0, - "partner":"5enq" + "partner":"6zoe" }, { "sim":290.0, - "partner":"6zo7" + "partner":"5enq" }, { "sim":290.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":290.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":290.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":290.0, @@ -819055,24 +822186,28 @@ }, { "sim":290.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":290.0, - "partner":"3noc" + "partner":"6zof" }, { "sim":290.0, - "partner":"6zo8" + "partner":"3noc" }, { "sim":290.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":290.0, "partner":"5enr" }, + { + "sim":290.0, + "partner":"7oul" + }, { "sim":290.0, "partner":"1svx" @@ -819083,39 +822218,39 @@ }, { "sim":290.0, - "partner":"6sgu" + "partner":"7b8t" }, { "sim":290.0, - "partner":"7oul" + "partner":"6zo9" }, { "sim":290.0, - "partner":"5nc5" + "partner":"6zog" }, { "sim":290.0, - "partner":"6zo9" + "partner":"5nc5" }, { "sim":290.0, - "partner":"6zog" + "partner":"7oum" }, { "sim":290.0, - "partner":"7b8t" + "partner":"5ens" }, { "sim":290.0, - "partner":"5ens" + "partner":"5en5" }, { "sim":290.0, - "partner":"7oum" + "partner":"6zoa" }, { "sim":290.0, - "partner":"5en5" + "partner":"6zoh" }, { "sim":290.0, @@ -819123,11 +822258,11 @@ }, { "sim":290.0, - "partner":"6zoa" + "partner":"6d65" }, { "sim":290.0, - "partner":"6zoh" + "partner":"6sgr" }, { "sim":290.0, @@ -819143,15 +822278,23 @@ }, { "sim":290.0, - "partner":"6d65" + "partner":"6zob" }, { "sim":290.0, - "partner":"6sgr" + "partner":"4dx5" }, { "sim":290.0, - "partner":"4dx5" + "partner":"5eno" + }, + { + "sim":290.0, + "partner":"6zo5" + }, + { + "sim":290.0, + "partner":"6q4n" }, { "sim":289.0, @@ -819209,10 +822352,6 @@ "sim":274.0, "partner":"6gcu" }, - { - "sim":274.0, - "partner":"8tzb" - }, { "sim":274.0, "partner":"8tzc" @@ -819229,6 +822368,10 @@ "sim":274.0, "partner":"8tzh" }, + { + "sim":274.0, + "partner":"8tzb" + }, { "sim":274.0, "partner":"5lel" @@ -819335,11 +822478,11 @@ }, { "sim":262.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":262.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":262.0, @@ -819387,11 +822530,11 @@ }, { "sim":258.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":258.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":256.0, @@ -819433,10 +822576,6 @@ "sim":247.0, "partner":"6qev" }, - { - "sim":246.0, - "partner":"8g4f" - }, { "sim":246.0, "partner":"8g42" @@ -819453,6 +822592,10 @@ "sim":246.0, "partner":"8g3k" }, + { + "sim":246.0, + "partner":"8g4f" + }, { "sim":246.0, "partner":"6sh9" @@ -819463,11 +822606,11 @@ }, { "sim":244.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":244.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":244.0, @@ -819479,11 +822622,11 @@ }, { "sim":242.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":242.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":240.0, @@ -819589,10 +822732,6 @@ "sim":228.0, "partner":"4hrn" }, - { - "sim":228.0, - "partner":"7pd8" - }, { "sim":228.0, "partner":"7pdd" @@ -819605,6 +822744,10 @@ "sim":228.0, "partner":"7pdh" }, + { + "sim":228.0, + "partner":"7pd8" + }, { "sim":224.0, "partner":"6moj" @@ -819743,23 +822886,23 @@ }, { "sim":119.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":119.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":119.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":119.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":119.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":119.0, @@ -819767,11 +822910,11 @@ }, { "sim":119.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":119.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":119.0, @@ -819845,10 +822988,6 @@ "sim":103.0, "partner":"2l6b" }, - { - "sim":103.0, - "partner":"5vhj" - }, { "sim":103.0, "partner":"5vhh" @@ -819879,15 +823018,15 @@ }, { "sim":103.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":103.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":103.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":103.0, @@ -819897,6 +823036,10 @@ "sim":103.0, "partner":"7vxw" }, + { + "sim":103.0, + "partner":"1uoh" + }, { "sim":103.0, "partner":"7vy4" @@ -819907,11 +823050,11 @@ }, { "sim":103.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":103.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":103.0, @@ -819923,15 +823066,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":102.0, @@ -819971,11 +823114,11 @@ }, { "sim":102.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":102.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":100.0, @@ -820003,11 +823146,11 @@ }, { "sim":99.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":99.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":99.0, @@ -820087,15 +823230,15 @@ }, { "sim":91.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":91.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":91.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":91.0, @@ -820115,16 +823258,24 @@ }, { "sim":90.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":90.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":90.0, "partner":"7roy" }, + { + "sim":90.0, + "partner":"8wqg" + }, + { + "sim":90.0, + "partner":"8wqe" + }, { "sim":90.0, "partner":"8wqh" @@ -820153,14 +823304,6 @@ "sim":90.0, "partner":"8wqd" }, - { - "sim":90.0, - "partner":"8wqg" - }, - { - "sim":90.0, - "partner":"8wqe" - }, { "sim":90.0, "partner":"8je1" @@ -820297,10 +823440,6 @@ "sim":84.0, "partner":"6e2g" }, - { - "sim":84.0, - "partner":"6v9x" - }, { "sim":84.0, "partner":"6v9y" @@ -820313,6 +823452,10 @@ "sim":84.0, "partner":"6v9w" }, + { + "sim":84.0, + "partner":"6v9x" + }, { "sim":84.0, "partner":"7or0" @@ -820433,10 +823576,6 @@ "sim":80.0, "partner":"5wo6" }, - { - "sim":80.0, - "partner":"5iwr" - }, { "sim":80.0, "partner":"5iwt" @@ -820491,11 +823630,11 @@ }, { "sim":80.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":80.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":80.0, @@ -820535,11 +823674,7 @@ }, { "sim":80.0, - "partner":"7t6m" - }, - { - "sim":80.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":80.0, @@ -820575,15 +823710,19 @@ }, { "sim":80.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":80.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":80.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":80.0, + "partner":"7t6k" }, { "sim":80.0, @@ -820591,7 +823730,7 @@ }, { "sim":80.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":80.0, @@ -820599,7 +823738,11 @@ }, { "sim":80.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":80.0, + "partner":"8ffn" }, { "sim":79.0, @@ -820613,14 +823756,6 @@ "sim":79.0, "partner":"6kyk" }, - { - "sim":78.0, - "partner":"3aaa" - }, - { - "sim":78.0, - "partner":"7dsb" - }, { "sim":78.0, "partner":"7df7" @@ -820631,15 +823766,15 @@ }, { "sim":78.0, - "partner":"2he0" + "partner":"7dsb" }, { "sim":78.0, - "partner":"6m11" + "partner":"3aaa" }, { "sim":78.0, - "partner":"6m12" + "partner":"2he0" }, { "sim":78.0, @@ -820665,6 +823800,14 @@ "sim":78.0, "partner":"4o1p" }, + { + "sim":78.0, + "partner":"6m11" + }, + { + "sim":78.0, + "partner":"6m12" + }, { "sim":78.0, "partner":"6aun" @@ -820743,11 +823886,11 @@ }, { "sim":74.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":74.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":74.0, @@ -820773,10 +823916,6 @@ "sim":73.0, "partner":"8sp8" }, - { - "sim":73.0, - "partner":"7k4a" - }, { "sim":73.0, "partner":"7k4b" @@ -820799,7 +823938,7 @@ }, { "sim":73.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":73.0, @@ -820815,7 +823954,7 @@ }, { "sim":73.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":73.0, @@ -820827,7 +823966,7 @@ }, { "sim":73.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":73.0, @@ -820845,6 +823984,10 @@ "sim":73.0, "partner":"6bo8" }, + { + "sim":73.0, + "partner":"6bo9" + }, { "sim":72.0, "partner":"1bi7" @@ -820887,15 +824030,15 @@ }, { "sim":68.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":68.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":68.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":68.0, @@ -821055,19 +824198,19 @@ }, { "sim":50.0, - "partner":"8u43" + "partner":"8u2z" }, { "sim":50.0, - "partner":"8u4d" + "partner":"8u43" }, { "sim":50.0, - "partner":"8u3a" + "partner":"8u4d" }, { "sim":50.0, - "partner":"8u2z" + "partner":"8u3a" }, { "sim":50.0, @@ -821081,18 +824224,10 @@ "sim":50.0, "partner":"5is0" }, - { - "sim":50.0, - "partner":"7mzc" - }, { "sim":50.0, "partner":"7l2v" }, - { - "sim":50.0, - "partner":"8t3l" - }, { "sim":50.0, "partner":"7mzd" @@ -821103,7 +824238,7 @@ }, { "sim":50.0, - "partner":"8t3m" + "partner":"8t3l" }, { "sim":50.0, @@ -821121,6 +824256,10 @@ "sim":50.0, "partner":"7l2x" }, + { + "sim":50.0, + "partner":"8t3m" + }, { "sim":50.0, "partner":"7l2r" @@ -821155,35 +824294,35 @@ }, { "sim":50.0, - "partner":"8t0y" + "partner":"7mzc" }, { "sim":50.0, - "partner":"8u3l" + "partner":"8t0y" }, { "sim":50.0, - "partner":"8t0c" + "partner":"8u30" }, { "sim":50.0, - "partner":"8u30" + "partner":"8u3c" }, { "sim":50.0, - "partner":"8t0e" + "partner":"8t0c" }, { "sim":50.0, - "partner":"8t10" + "partner":"8t0e" }, { "sim":50.0, - "partner":"8u3c" + "partner":"8t10" }, { "sim":50.0, - "partner":"7l2n" + "partner":"8u3l" }, { "sim":50.0, @@ -821219,32 +824358,28 @@ }, { "sim":50.0, - "partner":"7lqy" + "partner":"7l2n" }, { "sim":50.0, - "partner":"7lqz" + "partner":"7lqy" }, { "sim":50.0, - "partner":"7lr0" + "partner":"7lqz" }, { "sim":50.0, - "partner":"7lpd" + "partner":"7lr0" }, { "sim":50.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":50.0, "partner":"7rqv" }, - { - "sim":50.0, - "partner":"7lpe" - }, { "sim":50.0, "partner":"7rqw" @@ -821276,6 +824411,14 @@ { "sim":50.0, "partner":"7lpc" + }, + { + "sim":50.0, + "partner":"7rqu" + }, + { + "sim":50.0, + "partner":"7lpd" } ], "struct_thr_sim_designed":[ @@ -821476,11 +824619,11 @@ ], "seq_max_sim_designed":{ "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, "seq_max_sim_natural":{ "sim":342.0, - "partner":"7yz0" + "partner":"6mzf" }, "struct_max_sim_designed":{ "sim":1.0, @@ -821600,51 +824743,51 @@ "seq_thr_sim_designed":[ { "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":342.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":342.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":342.0, - "partner":"8ql8" + "partner":"8qla" }, { "sim":342.0, - "partner":"8ql3" + "partner":"8ql8" }, { "sim":342.0, - "partner":"9f8g" + "partner":"4dui" }, { "sim":342.0, - "partner":"8ql6" + "partner":"8qea" }, { "sim":342.0, - "partner":"8ql5" + "partner":"8qlb" }, { "sim":342.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":342.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":342.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":342.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":298.0, @@ -821660,19 +824803,19 @@ }, { "sim":295.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":295.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":291.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":291.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":290.0, @@ -821728,11 +824871,11 @@ }, { "sim":261.0, - "partner":"7z72" + "partner":"7z7e" }, { "sim":261.0, - "partner":"7z7e" + "partner":"7z72" }, { "sim":259.0, @@ -821800,7 +824943,7 @@ }, { "sim":253.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":253.0, @@ -821808,7 +824951,7 @@ }, { "sim":253.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":252.0, @@ -821864,11 +825007,11 @@ }, { "sim":223.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":223.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":223.0, @@ -821892,11 +825035,11 @@ }, { "sim":207.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":207.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":205.0, @@ -821908,19 +825051,23 @@ }, { "sim":198.0, - "partner":"8rci" + "partner":"7z73" }, { "sim":198.0, - "partner":"7z73" + "partner":"8rci" }, { "sim":192.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":192.0, - "partner":"4qfv" + "partner":"4o60" + }, + { + "sim":187.0, + "partner":"9glq" }, { "sim":178.0, @@ -821968,30 +825115,18 @@ } ], "seq_thr_sim_natural":[ - { - "sim":342.0, - "partner":"7yz0" - }, { "sim":342.0, "partner":"6mzf" }, { "sim":342.0, - "partner":"7yz1" - }, - { - "sim":342.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":342.0, "partner":"5nqt" }, - { - "sim":342.0, - "partner":"6mze" - }, { "sim":342.0, "partner":"7yz2" @@ -822002,11 +825137,11 @@ }, { "sim":342.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":342.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":342.0, @@ -822018,23 +825153,23 @@ }, { "sim":342.0, - "partner":"4lnu" + "partner":"7yz6" }, { "sim":342.0, - "partner":"7yz6" + "partner":"4lnu" }, { "sim":342.0, - "partner":"4drx" + "partner":"6zwb" }, { "sim":342.0, - "partner":"5nm5" + "partner":"4drx" }, { "sim":342.0, - "partner":"6zwb" + "partner":"5nm5" }, { "sim":342.0, @@ -822048,6 +825183,18 @@ "sim":342.0, "partner":"7yyz" }, + { + "sim":342.0, + "partner":"7yz0" + }, + { + "sim":342.0, + "partner":"7yz1" + }, + { + "sim":342.0, + "partner":"7z01" + }, { "sim":338.0, "partner":"6bbn" @@ -822078,11 +825225,11 @@ }, { "sim":315.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":315.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":312.0, @@ -822146,27 +825293,19 @@ }, { "sim":290.0, - "partner":"5eno" - }, - { - "sim":290.0, - "partner":"6zob" - }, - { - "sim":290.0, - "partner":"6zo5" + "partner":"4dx6" }, { "sim":290.0, - "partner":"4dx6" + "partner":"6sgs" }, { "sim":290.0, - "partner":"6q4n" + "partner":"6zoc" }, { "sim":290.0, - "partner":"6zoc" + "partner":"6zo6" }, { "sim":290.0, @@ -822174,11 +825313,11 @@ }, { "sim":290.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":290.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":290.0, @@ -822186,11 +825325,11 @@ }, { "sim":290.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":290.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":290.0, @@ -822198,11 +825337,7 @@ }, { "sim":290.0, - "partner":"6zod" - }, - { - "sim":290.0, - "partner":"7b8r" + "partner":"6zo7" }, { "sim":290.0, @@ -822210,23 +825345,23 @@ }, { "sim":290.0, - "partner":"5enq" + "partner":"6zoe" }, { "sim":290.0, - "partner":"6zo7" + "partner":"5enq" }, { "sim":290.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":290.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":290.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":290.0, @@ -822242,24 +825377,28 @@ }, { "sim":290.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":290.0, - "partner":"3noc" + "partner":"6zof" }, { "sim":290.0, - "partner":"6zo8" + "partner":"3noc" }, { "sim":290.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":290.0, "partner":"5enr" }, + { + "sim":290.0, + "partner":"7oul" + }, { "sim":290.0, "partner":"1svx" @@ -822270,39 +825409,39 @@ }, { "sim":290.0, - "partner":"6sgu" + "partner":"7b8t" }, { "sim":290.0, - "partner":"7oul" + "partner":"6zo9" }, { "sim":290.0, - "partner":"5nc5" + "partner":"6zog" }, { "sim":290.0, - "partner":"6zo9" + "partner":"5nc5" }, { "sim":290.0, - "partner":"6zog" + "partner":"7oum" }, { "sim":290.0, - "partner":"7b8t" + "partner":"5ens" }, { "sim":290.0, - "partner":"5ens" + "partner":"5en5" }, { "sim":290.0, - "partner":"7oum" + "partner":"6zoa" }, { "sim":290.0, - "partner":"5en5" + "partner":"6zoh" }, { "sim":290.0, @@ -822310,11 +825449,11 @@ }, { "sim":290.0, - "partner":"6zoa" + "partner":"6d65" }, { "sim":290.0, - "partner":"6zoh" + "partner":"6sgr" }, { "sim":290.0, @@ -822330,15 +825469,23 @@ }, { "sim":290.0, - "partner":"6d65" + "partner":"6zob" }, { "sim":290.0, - "partner":"6sgr" + "partner":"4dx5" }, { "sim":290.0, - "partner":"4dx5" + "partner":"5eno" + }, + { + "sim":290.0, + "partner":"6zo5" + }, + { + "sim":290.0, + "partner":"6q4n" }, { "sim":289.0, @@ -822396,10 +825543,6 @@ "sim":274.0, "partner":"6gcu" }, - { - "sim":274.0, - "partner":"8tzb" - }, { "sim":274.0, "partner":"8tzc" @@ -822416,6 +825559,10 @@ "sim":274.0, "partner":"8tzh" }, + { + "sim":274.0, + "partner":"8tzb" + }, { "sim":274.0, "partner":"5lel" @@ -822526,11 +825673,11 @@ }, { "sim":262.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":262.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":262.0, @@ -822578,11 +825725,11 @@ }, { "sim":258.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":258.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":256.0, @@ -822624,10 +825771,6 @@ "sim":247.0, "partner":"6qev" }, - { - "sim":246.0, - "partner":"8g4f" - }, { "sim":246.0, "partner":"8g42" @@ -822644,6 +825787,10 @@ "sim":246.0, "partner":"8g3k" }, + { + "sim":246.0, + "partner":"8g4f" + }, { "sim":246.0, "partner":"6sh9" @@ -822654,11 +825801,11 @@ }, { "sim":244.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":244.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":244.0, @@ -822670,11 +825817,11 @@ }, { "sim":242.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":242.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":240.0, @@ -822780,10 +825927,6 @@ "sim":228.0, "partner":"4hrn" }, - { - "sim":228.0, - "partner":"7pd8" - }, { "sim":228.0, "partner":"7pdd" @@ -822796,6 +825939,10 @@ "sim":228.0, "partner":"7pdh" }, + { + "sim":228.0, + "partner":"7pd8" + }, { "sim":224.0, "partner":"6moj" @@ -822934,23 +826081,23 @@ }, { "sim":119.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":119.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":119.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":119.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":119.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":119.0, @@ -822958,11 +826105,11 @@ }, { "sim":119.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":119.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":119.0, @@ -823036,10 +826183,6 @@ "sim":103.0, "partner":"2l6b" }, - { - "sim":103.0, - "partner":"5vhj" - }, { "sim":103.0, "partner":"5vhh" @@ -823070,15 +826213,15 @@ }, { "sim":103.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":103.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":103.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":103.0, @@ -823088,6 +826231,10 @@ "sim":103.0, "partner":"7vxw" }, + { + "sim":103.0, + "partner":"1uoh" + }, { "sim":103.0, "partner":"7vy4" @@ -823098,11 +826245,11 @@ }, { "sim":103.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":103.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":103.0, @@ -823114,15 +826261,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":102.0, @@ -823162,11 +826309,11 @@ }, { "sim":102.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":102.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":100.0, @@ -823194,11 +826341,11 @@ }, { "sim":99.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":99.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":99.0, @@ -823278,15 +826425,15 @@ }, { "sim":91.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":91.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":91.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":91.0, @@ -823306,16 +826453,24 @@ }, { "sim":90.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":90.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":90.0, "partner":"7roy" }, + { + "sim":90.0, + "partner":"8wqg" + }, + { + "sim":90.0, + "partner":"8wqe" + }, { "sim":90.0, "partner":"8wqh" @@ -823344,14 +826499,6 @@ "sim":90.0, "partner":"8wqd" }, - { - "sim":90.0, - "partner":"8wqg" - }, - { - "sim":90.0, - "partner":"8wqe" - }, { "sim":90.0, "partner":"8je1" @@ -823496,10 +826643,6 @@ "sim":84.0, "partner":"6e2g" }, - { - "sim":84.0, - "partner":"6v9x" - }, { "sim":84.0, "partner":"6v9y" @@ -823512,6 +826655,10 @@ "sim":84.0, "partner":"6v9w" }, + { + "sim":84.0, + "partner":"6v9x" + }, { "sim":84.0, "partner":"7or0" @@ -823632,10 +826779,6 @@ "sim":80.0, "partner":"5wo6" }, - { - "sim":80.0, - "partner":"5iwr" - }, { "sim":80.0, "partner":"5iwt" @@ -823690,11 +826833,11 @@ }, { "sim":80.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":80.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":80.0, @@ -823734,11 +826877,7 @@ }, { "sim":80.0, - "partner":"7t6m" - }, - { - "sim":80.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":80.0, @@ -823774,15 +826913,19 @@ }, { "sim":80.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":80.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":80.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":80.0, + "partner":"7t6k" }, { "sim":80.0, @@ -823790,7 +826933,7 @@ }, { "sim":80.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":80.0, @@ -823798,7 +826941,11 @@ }, { "sim":80.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":80.0, + "partner":"8ffn" }, { "sim":79.0, @@ -823812,14 +826959,6 @@ "sim":79.0, "partner":"6kyk" }, - { - "sim":78.0, - "partner":"3aaa" - }, - { - "sim":78.0, - "partner":"7dsb" - }, { "sim":78.0, "partner":"7df7" @@ -823830,15 +826969,15 @@ }, { "sim":78.0, - "partner":"2he0" + "partner":"7dsb" }, { "sim":78.0, - "partner":"6m11" + "partner":"3aaa" }, { "sim":78.0, - "partner":"6m12" + "partner":"2he0" }, { "sim":78.0, @@ -823864,6 +827003,14 @@ "sim":78.0, "partner":"4o1p" }, + { + "sim":78.0, + "partner":"6m11" + }, + { + "sim":78.0, + "partner":"6m12" + }, { "sim":78.0, "partner":"6aun" @@ -823942,11 +827089,11 @@ }, { "sim":74.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":74.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":74.0, @@ -823972,10 +827119,6 @@ "sim":73.0, "partner":"8sp8" }, - { - "sim":73.0, - "partner":"7k4a" - }, { "sim":73.0, "partner":"7k4b" @@ -823998,7 +827141,7 @@ }, { "sim":73.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":73.0, @@ -824014,7 +827157,7 @@ }, { "sim":73.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":73.0, @@ -824026,7 +827169,7 @@ }, { "sim":73.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":73.0, @@ -824044,6 +827187,10 @@ "sim":73.0, "partner":"6bo8" }, + { + "sim":73.0, + "partner":"6bo9" + }, { "sim":73.0, "partner":"9cuj" @@ -824082,11 +827229,11 @@ }, { "sim":72.0, - "partner":"9cuh" + "partner":"9cui" }, { "sim":72.0, - "partner":"9cui" + "partner":"9cuh" }, { "sim":70.0, @@ -824102,15 +827249,15 @@ }, { "sim":68.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":68.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":68.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":68.0, @@ -824270,19 +827417,19 @@ }, { "sim":50.0, - "partner":"8u43" + "partner":"8u2z" }, { "sim":50.0, - "partner":"8u4d" + "partner":"8u43" }, { "sim":50.0, - "partner":"8u3a" + "partner":"8u4d" }, { "sim":50.0, - "partner":"8u2z" + "partner":"8u3a" }, { "sim":50.0, @@ -824296,18 +827443,10 @@ "sim":50.0, "partner":"5is0" }, - { - "sim":50.0, - "partner":"7mzc" - }, { "sim":50.0, "partner":"7l2v" }, - { - "sim":50.0, - "partner":"8t3l" - }, { "sim":50.0, "partner":"7mzd" @@ -824318,7 +827457,7 @@ }, { "sim":50.0, - "partner":"8t3m" + "partner":"8t3l" }, { "sim":50.0, @@ -824336,6 +827475,10 @@ "sim":50.0, "partner":"7l2x" }, + { + "sim":50.0, + "partner":"8t3m" + }, { "sim":50.0, "partner":"7l2r" @@ -824370,35 +827513,35 @@ }, { "sim":50.0, - "partner":"8t0y" + "partner":"7mzc" }, { "sim":50.0, - "partner":"8u3l" + "partner":"8t0y" }, { "sim":50.0, - "partner":"8t0c" + "partner":"8u30" }, { "sim":50.0, - "partner":"8u30" + "partner":"8u3c" }, { "sim":50.0, - "partner":"8t0e" + "partner":"8t0c" }, { "sim":50.0, - "partner":"8t10" + "partner":"8t0e" }, { "sim":50.0, - "partner":"8u3c" + "partner":"8t10" }, { "sim":50.0, - "partner":"7l2n" + "partner":"8u3l" }, { "sim":50.0, @@ -824434,32 +827577,28 @@ }, { "sim":50.0, - "partner":"7lqy" + "partner":"7l2n" }, { "sim":50.0, - "partner":"7lqz" + "partner":"7lqy" }, { "sim":50.0, - "partner":"7lr0" + "partner":"7lqz" }, { "sim":50.0, - "partner":"7lpd" + "partner":"7lr0" }, { "sim":50.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":50.0, "partner":"7rqv" }, - { - "sim":50.0, - "partner":"7lpe" - }, { "sim":50.0, "partner":"7rqw" @@ -824491,6 +827630,14 @@ { "sim":50.0, "partner":"7lpc" + }, + { + "sim":50.0, + "partner":"7rqu" + }, + { + "sim":50.0, + "partner":"7lpd" } ], "struct_thr_sim_designed":[ @@ -824623,11 +827770,11 @@ ], "seq_max_sim_designed":{ "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, "seq_max_sim_natural":{ "sim":342.0, - "partner":"7yz0" + "partner":"6mzf" }, "struct_max_sim_designed":{ "sim":0.997699976, @@ -824747,15 +827894,15 @@ "seq_thr_sim_designed":[ { "sim":342.0, - "partner":"8qea" + "partner":"8ql3" }, { "sim":342.0, - "partner":"4dui" + "partner":"9f8g" }, { "sim":342.0, - "partner":"8ql9" + "partner":"8ql6" }, { "sim":342.0, @@ -824763,35 +827910,35 @@ }, { "sim":342.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":342.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":342.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":342.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":342.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":342.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":342.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":342.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":298.0, @@ -824807,19 +827954,19 @@ }, { "sim":295.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":295.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":291.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":291.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":290.0, @@ -824875,11 +828022,11 @@ }, { "sim":261.0, - "partner":"7z72" + "partner":"7z7e" }, { "sim":261.0, - "partner":"7z7e" + "partner":"7z72" }, { "sim":259.0, @@ -824947,7 +828094,7 @@ }, { "sim":253.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":253.0, @@ -824955,7 +828102,7 @@ }, { "sim":253.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":252.0, @@ -825011,11 +828158,11 @@ }, { "sim":223.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":223.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":223.0, @@ -825039,11 +828186,11 @@ }, { "sim":207.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":207.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":205.0, @@ -825055,19 +828202,23 @@ }, { "sim":198.0, - "partner":"8rci" + "partner":"7z73" }, { "sim":198.0, - "partner":"7z73" + "partner":"8rci" }, { "sim":192.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":192.0, - "partner":"4qfv" + "partner":"4o60" + }, + { + "sim":187.0, + "partner":"9glq" }, { "sim":178.0, @@ -825115,30 +828266,18 @@ } ], "seq_thr_sim_natural":[ - { - "sim":342.0, - "partner":"7yz0" - }, { "sim":342.0, "partner":"6mzf" }, { "sim":342.0, - "partner":"7yz1" - }, - { - "sim":342.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":342.0, "partner":"5nqt" }, - { - "sim":342.0, - "partner":"6mze" - }, { "sim":342.0, "partner":"7yz2" @@ -825149,11 +828288,11 @@ }, { "sim":342.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":342.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":342.0, @@ -825165,23 +828304,23 @@ }, { "sim":342.0, - "partner":"4lnu" + "partner":"7yz6" }, { "sim":342.0, - "partner":"7yz6" + "partner":"4lnu" }, { "sim":342.0, - "partner":"4drx" + "partner":"6zwb" }, { "sim":342.0, - "partner":"5nm5" + "partner":"4drx" }, { "sim":342.0, - "partner":"6zwb" + "partner":"5nm5" }, { "sim":342.0, @@ -825195,6 +828334,18 @@ "sim":342.0, "partner":"7yyz" }, + { + "sim":342.0, + "partner":"7yz0" + }, + { + "sim":342.0, + "partner":"7yz1" + }, + { + "sim":342.0, + "partner":"7z01" + }, { "sim":338.0, "partner":"6bbn" @@ -825225,11 +828376,11 @@ }, { "sim":315.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":315.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":312.0, @@ -825293,27 +828444,19 @@ }, { "sim":290.0, - "partner":"5eno" - }, - { - "sim":290.0, - "partner":"6zob" - }, - { - "sim":290.0, - "partner":"6zo5" + "partner":"4dx6" }, { "sim":290.0, - "partner":"4dx6" + "partner":"6sgs" }, { "sim":290.0, - "partner":"6q4n" + "partner":"6zoc" }, { "sim":290.0, - "partner":"6zoc" + "partner":"6zo6" }, { "sim":290.0, @@ -825321,11 +828464,11 @@ }, { "sim":290.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":290.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":290.0, @@ -825333,11 +828476,11 @@ }, { "sim":290.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":290.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":290.0, @@ -825345,11 +828488,7 @@ }, { "sim":290.0, - "partner":"6zod" - }, - { - "sim":290.0, - "partner":"7b8r" + "partner":"6zo7" }, { "sim":290.0, @@ -825357,23 +828496,23 @@ }, { "sim":290.0, - "partner":"5enq" + "partner":"6zoe" }, { "sim":290.0, - "partner":"6zo7" + "partner":"5enq" }, { "sim":290.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":290.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":290.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":290.0, @@ -825389,24 +828528,28 @@ }, { "sim":290.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":290.0, - "partner":"3noc" + "partner":"6zof" }, { "sim":290.0, - "partner":"6zo8" + "partner":"3noc" }, { "sim":290.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":290.0, "partner":"5enr" }, + { + "sim":290.0, + "partner":"7oul" + }, { "sim":290.0, "partner":"1svx" @@ -825417,39 +828560,39 @@ }, { "sim":290.0, - "partner":"6sgu" + "partner":"7b8t" }, { "sim":290.0, - "partner":"7oul" + "partner":"6zo9" }, { "sim":290.0, - "partner":"5nc5" + "partner":"6zog" }, { "sim":290.0, - "partner":"6zo9" + "partner":"5nc5" }, { "sim":290.0, - "partner":"6zog" + "partner":"7oum" }, { "sim":290.0, - "partner":"7b8t" + "partner":"5ens" }, { "sim":290.0, - "partner":"5ens" + "partner":"5en5" }, { "sim":290.0, - "partner":"7oum" + "partner":"6zoa" }, { "sim":290.0, - "partner":"5en5" + "partner":"6zoh" }, { "sim":290.0, @@ -825457,11 +828600,11 @@ }, { "sim":290.0, - "partner":"6zoa" + "partner":"6d65" }, { "sim":290.0, - "partner":"6zoh" + "partner":"6sgr" }, { "sim":290.0, @@ -825477,15 +828620,23 @@ }, { "sim":290.0, - "partner":"6d65" + "partner":"6zob" }, { "sim":290.0, - "partner":"6sgr" + "partner":"4dx5" }, { "sim":290.0, - "partner":"4dx5" + "partner":"5eno" + }, + { + "sim":290.0, + "partner":"6zo5" + }, + { + "sim":290.0, + "partner":"6q4n" }, { "sim":289.0, @@ -825543,10 +828694,6 @@ "sim":274.0, "partner":"6gcu" }, - { - "sim":274.0, - "partner":"8tzb" - }, { "sim":274.0, "partner":"8tzc" @@ -825563,6 +828710,10 @@ "sim":274.0, "partner":"8tzh" }, + { + "sim":274.0, + "partner":"8tzb" + }, { "sim":274.0, "partner":"5lel" @@ -825673,11 +828824,11 @@ }, { "sim":262.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":262.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":262.0, @@ -825725,11 +828876,11 @@ }, { "sim":258.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":258.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":256.0, @@ -825771,10 +828922,6 @@ "sim":247.0, "partner":"6qev" }, - { - "sim":246.0, - "partner":"8g4f" - }, { "sim":246.0, "partner":"8g42" @@ -825791,6 +828938,10 @@ "sim":246.0, "partner":"8g3k" }, + { + "sim":246.0, + "partner":"8g4f" + }, { "sim":246.0, "partner":"6sh9" @@ -825801,11 +828952,11 @@ }, { "sim":244.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":244.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":244.0, @@ -825817,11 +828968,11 @@ }, { "sim":242.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":242.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":240.0, @@ -825927,10 +829078,6 @@ "sim":228.0, "partner":"4hrn" }, - { - "sim":228.0, - "partner":"7pd8" - }, { "sim":228.0, "partner":"7pdd" @@ -825943,6 +829090,10 @@ "sim":228.0, "partner":"7pdh" }, + { + "sim":228.0, + "partner":"7pd8" + }, { "sim":224.0, "partner":"6moj" @@ -826081,23 +829232,23 @@ }, { "sim":119.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":119.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":119.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":119.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":119.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":119.0, @@ -826105,11 +829256,11 @@ }, { "sim":119.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":119.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":119.0, @@ -826183,10 +829334,6 @@ "sim":103.0, "partner":"2l6b" }, - { - "sim":103.0, - "partner":"5vhj" - }, { "sim":103.0, "partner":"5vhh" @@ -826217,15 +829364,15 @@ }, { "sim":103.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":103.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":103.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":103.0, @@ -826235,6 +829382,10 @@ "sim":103.0, "partner":"7vxw" }, + { + "sim":103.0, + "partner":"1uoh" + }, { "sim":103.0, "partner":"7vy4" @@ -826245,11 +829396,11 @@ }, { "sim":103.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":103.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":103.0, @@ -826261,15 +829412,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":102.0, @@ -826309,11 +829460,11 @@ }, { "sim":102.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":102.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":100.0, @@ -826341,11 +829492,11 @@ }, { "sim":99.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":99.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":99.0, @@ -826425,15 +829576,15 @@ }, { "sim":91.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":91.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":91.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":91.0, @@ -826453,16 +829604,24 @@ }, { "sim":90.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":90.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":90.0, "partner":"7roy" }, + { + "sim":90.0, + "partner":"8wqg" + }, + { + "sim":90.0, + "partner":"8wqe" + }, { "sim":90.0, "partner":"8wqh" @@ -826491,14 +829650,6 @@ "sim":90.0, "partner":"8wqd" }, - { - "sim":90.0, - "partner":"8wqg" - }, - { - "sim":90.0, - "partner":"8wqe" - }, { "sim":90.0, "partner":"8je1" @@ -826643,10 +829794,6 @@ "sim":84.0, "partner":"6e2g" }, - { - "sim":84.0, - "partner":"6v9x" - }, { "sim":84.0, "partner":"6v9y" @@ -826659,6 +829806,10 @@ "sim":84.0, "partner":"6v9w" }, + { + "sim":84.0, + "partner":"6v9x" + }, { "sim":84.0, "partner":"7or0" @@ -826779,10 +829930,6 @@ "sim":80.0, "partner":"5wo6" }, - { - "sim":80.0, - "partner":"5iwr" - }, { "sim":80.0, "partner":"5iwt" @@ -826837,11 +829984,11 @@ }, { "sim":80.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":80.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":80.0, @@ -826881,11 +830028,7 @@ }, { "sim":80.0, - "partner":"7t6m" - }, - { - "sim":80.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":80.0, @@ -826921,15 +830064,19 @@ }, { "sim":80.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":80.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":80.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":80.0, + "partner":"7t6k" }, { "sim":80.0, @@ -826937,7 +830084,7 @@ }, { "sim":80.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":80.0, @@ -826945,7 +830092,11 @@ }, { "sim":80.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":80.0, + "partner":"8ffn" }, { "sim":79.0, @@ -826959,14 +830110,6 @@ "sim":79.0, "partner":"6kyk" }, - { - "sim":78.0, - "partner":"3aaa" - }, - { - "sim":78.0, - "partner":"7dsb" - }, { "sim":78.0, "partner":"7df7" @@ -826977,15 +830120,15 @@ }, { "sim":78.0, - "partner":"2he0" + "partner":"7dsb" }, { "sim":78.0, - "partner":"6m11" + "partner":"3aaa" }, { "sim":78.0, - "partner":"6m12" + "partner":"2he0" }, { "sim":78.0, @@ -827011,6 +830154,14 @@ "sim":78.0, "partner":"4o1p" }, + { + "sim":78.0, + "partner":"6m11" + }, + { + "sim":78.0, + "partner":"6m12" + }, { "sim":78.0, "partner":"6aun" @@ -827089,11 +830240,11 @@ }, { "sim":74.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":74.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":74.0, @@ -827119,10 +830270,6 @@ "sim":73.0, "partner":"8sp8" }, - { - "sim":73.0, - "partner":"7k4a" - }, { "sim":73.0, "partner":"7k4b" @@ -827145,7 +830292,7 @@ }, { "sim":73.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":73.0, @@ -827161,7 +830308,7 @@ }, { "sim":73.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":73.0, @@ -827173,7 +830320,7 @@ }, { "sim":73.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":73.0, @@ -827191,6 +830338,10 @@ "sim":73.0, "partner":"6bo8" }, + { + "sim":73.0, + "partner":"6bo9" + }, { "sim":73.0, "partner":"9cuj" @@ -827229,11 +830380,11 @@ }, { "sim":72.0, - "partner":"9cuh" + "partner":"9cui" }, { "sim":72.0, - "partner":"9cui" + "partner":"9cuh" }, { "sim":70.0, @@ -827249,15 +830400,15 @@ }, { "sim":68.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":68.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":68.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":68.0, @@ -827417,19 +830568,19 @@ }, { "sim":50.0, - "partner":"8u43" + "partner":"8u2z" }, { "sim":50.0, - "partner":"8u4d" + "partner":"8u43" }, { "sim":50.0, - "partner":"8u3a" + "partner":"8u4d" }, { "sim":50.0, - "partner":"8u2z" + "partner":"8u3a" }, { "sim":50.0, @@ -827443,18 +830594,10 @@ "sim":50.0, "partner":"5is0" }, - { - "sim":50.0, - "partner":"7mzc" - }, { "sim":50.0, "partner":"7l2v" }, - { - "sim":50.0, - "partner":"8t3l" - }, { "sim":50.0, "partner":"7mzd" @@ -827465,7 +830608,7 @@ }, { "sim":50.0, - "partner":"8t3m" + "partner":"8t3l" }, { "sim":50.0, @@ -827483,6 +830626,10 @@ "sim":50.0, "partner":"7l2x" }, + { + "sim":50.0, + "partner":"8t3m" + }, { "sim":50.0, "partner":"7l2r" @@ -827517,35 +830664,35 @@ }, { "sim":50.0, - "partner":"8t0y" + "partner":"7mzc" }, { "sim":50.0, - "partner":"8u3l" + "partner":"8t0y" }, { "sim":50.0, - "partner":"8t0c" + "partner":"8u30" }, { "sim":50.0, - "partner":"8u30" + "partner":"8u3c" }, { "sim":50.0, - "partner":"8t0e" + "partner":"8t0c" }, { "sim":50.0, - "partner":"8t10" + "partner":"8t0e" }, { "sim":50.0, - "partner":"8u3c" + "partner":"8t10" }, { "sim":50.0, - "partner":"7l2n" + "partner":"8u3l" }, { "sim":50.0, @@ -827581,32 +830728,28 @@ }, { "sim":50.0, - "partner":"7lqy" + "partner":"7l2n" }, { "sim":50.0, - "partner":"7lqz" + "partner":"7lqy" }, { "sim":50.0, - "partner":"7lr0" + "partner":"7lqz" }, { "sim":50.0, - "partner":"7lpd" + "partner":"7lr0" }, { "sim":50.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":50.0, "partner":"7rqv" }, - { - "sim":50.0, - "partner":"7lpe" - }, { "sim":50.0, "partner":"7rqw" @@ -827638,6 +830781,14 @@ { "sim":50.0, "partner":"7lpc" + }, + { + "sim":50.0, + "partner":"7rqu" + }, + { + "sim":50.0, + "partner":"7lpd" } ], "struct_thr_sim_designed":[ @@ -827838,11 +830989,11 @@ ], "seq_max_sim_designed":{ "sim":342.0, - "partner":"8qea" + "partner":"8ql3" }, "seq_max_sim_natural":{ "sim":342.0, - "partner":"7yz0" + "partner":"6mzf" }, "struct_max_sim_designed":{ "sim":0.9994999766, @@ -827962,19 +831113,19 @@ "seq_thr_sim_designed":[ { "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":342.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":342.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":342.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":342.0, @@ -827982,19 +831133,19 @@ }, { "sim":342.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":342.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":342.0, - "partner":"8ql6" + "partner":"8ql9" }, { "sim":342.0, - "partner":"8ql5" + "partner":"8ql7" }, { "sim":342.0, @@ -828002,11 +831153,11 @@ }, { "sim":342.0, - "partner":"8ql7" + "partner":"8ql2" }, { "sim":342.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":298.0, @@ -828022,19 +831173,19 @@ }, { "sim":295.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":295.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":291.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":291.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":290.0, @@ -828090,11 +831241,11 @@ }, { "sim":261.0, - "partner":"7z72" + "partner":"7z7e" }, { "sim":261.0, - "partner":"7z7e" + "partner":"7z72" }, { "sim":259.0, @@ -828162,7 +831313,7 @@ }, { "sim":253.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":253.0, @@ -828170,7 +831321,7 @@ }, { "sim":253.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":252.0, @@ -828226,11 +831377,11 @@ }, { "sim":223.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":223.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":223.0, @@ -828254,11 +831405,11 @@ }, { "sim":207.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":207.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":205.0, @@ -828270,19 +831421,23 @@ }, { "sim":198.0, - "partner":"8rci" + "partner":"7z73" }, { "sim":198.0, - "partner":"7z73" + "partner":"8rci" }, { "sim":192.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":192.0, - "partner":"4qfv" + "partner":"4o60" + }, + { + "sim":187.0, + "partner":"9glq" }, { "sim":178.0, @@ -828330,30 +831485,18 @@ } ], "seq_thr_sim_natural":[ - { - "sim":342.0, - "partner":"7yz0" - }, { "sim":342.0, "partner":"6mzf" }, { "sim":342.0, - "partner":"7yz1" - }, - { - "sim":342.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":342.0, "partner":"5nqt" }, - { - "sim":342.0, - "partner":"6mze" - }, { "sim":342.0, "partner":"7yz2" @@ -828364,11 +831507,11 @@ }, { "sim":342.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":342.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":342.0, @@ -828380,23 +831523,23 @@ }, { "sim":342.0, - "partner":"4lnu" + "partner":"7yz6" }, { "sim":342.0, - "partner":"7yz6" + "partner":"4lnu" }, { "sim":342.0, - "partner":"4drx" + "partner":"6zwb" }, { "sim":342.0, - "partner":"5nm5" + "partner":"4drx" }, { "sim":342.0, - "partner":"6zwb" + "partner":"5nm5" }, { "sim":342.0, @@ -828410,6 +831553,18 @@ "sim":342.0, "partner":"7yyz" }, + { + "sim":342.0, + "partner":"7yz0" + }, + { + "sim":342.0, + "partner":"7yz1" + }, + { + "sim":342.0, + "partner":"7z01" + }, { "sim":338.0, "partner":"6bbn" @@ -828440,11 +831595,11 @@ }, { "sim":315.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":315.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":312.0, @@ -828508,27 +831663,19 @@ }, { "sim":290.0, - "partner":"5eno" - }, - { - "sim":290.0, - "partner":"6zob" - }, - { - "sim":290.0, - "partner":"6zo5" + "partner":"4dx6" }, { "sim":290.0, - "partner":"4dx6" + "partner":"6sgs" }, { "sim":290.0, - "partner":"6q4n" + "partner":"6zoc" }, { "sim":290.0, - "partner":"6zoc" + "partner":"6zo6" }, { "sim":290.0, @@ -828536,11 +831683,11 @@ }, { "sim":290.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":290.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":290.0, @@ -828548,11 +831695,11 @@ }, { "sim":290.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":290.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":290.0, @@ -828560,11 +831707,7 @@ }, { "sim":290.0, - "partner":"6zod" - }, - { - "sim":290.0, - "partner":"7b8r" + "partner":"6zo7" }, { "sim":290.0, @@ -828572,23 +831715,23 @@ }, { "sim":290.0, - "partner":"5enq" + "partner":"6zoe" }, { "sim":290.0, - "partner":"6zo7" + "partner":"5enq" }, { "sim":290.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":290.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":290.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":290.0, @@ -828604,24 +831747,28 @@ }, { "sim":290.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":290.0, - "partner":"3noc" + "partner":"6zof" }, { "sim":290.0, - "partner":"6zo8" + "partner":"3noc" }, { "sim":290.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":290.0, "partner":"5enr" }, + { + "sim":290.0, + "partner":"7oul" + }, { "sim":290.0, "partner":"1svx" @@ -828632,39 +831779,39 @@ }, { "sim":290.0, - "partner":"6sgu" + "partner":"7b8t" }, { "sim":290.0, - "partner":"7oul" + "partner":"6zo9" }, { "sim":290.0, - "partner":"5nc5" + "partner":"6zog" }, { "sim":290.0, - "partner":"6zo9" + "partner":"5nc5" }, { "sim":290.0, - "partner":"6zog" + "partner":"7oum" }, { "sim":290.0, - "partner":"7b8t" + "partner":"5ens" }, { "sim":290.0, - "partner":"5ens" + "partner":"5en5" }, { "sim":290.0, - "partner":"7oum" + "partner":"6zoa" }, { "sim":290.0, - "partner":"5en5" + "partner":"6zoh" }, { "sim":290.0, @@ -828672,11 +831819,11 @@ }, { "sim":290.0, - "partner":"6zoa" + "partner":"6d65" }, { "sim":290.0, - "partner":"6zoh" + "partner":"6sgr" }, { "sim":290.0, @@ -828692,15 +831839,23 @@ }, { "sim":290.0, - "partner":"6d65" + "partner":"6zob" }, { "sim":290.0, - "partner":"6sgr" + "partner":"4dx5" }, { "sim":290.0, - "partner":"4dx5" + "partner":"5eno" + }, + { + "sim":290.0, + "partner":"6zo5" + }, + { + "sim":290.0, + "partner":"6q4n" }, { "sim":289.0, @@ -828758,10 +831913,6 @@ "sim":274.0, "partner":"6gcu" }, - { - "sim":274.0, - "partner":"8tzb" - }, { "sim":274.0, "partner":"8tzc" @@ -828778,6 +831929,10 @@ "sim":274.0, "partner":"8tzh" }, + { + "sim":274.0, + "partner":"8tzb" + }, { "sim":274.0, "partner":"5lel" @@ -828884,11 +832039,11 @@ }, { "sim":262.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":262.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":262.0, @@ -828936,11 +832091,11 @@ }, { "sim":258.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":258.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":256.0, @@ -828982,10 +832137,6 @@ "sim":247.0, "partner":"6qev" }, - { - "sim":246.0, - "partner":"8g4f" - }, { "sim":246.0, "partner":"8g42" @@ -829002,6 +832153,10 @@ "sim":246.0, "partner":"8g3k" }, + { + "sim":246.0, + "partner":"8g4f" + }, { "sim":246.0, "partner":"6sh9" @@ -829012,11 +832167,11 @@ }, { "sim":244.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":244.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":244.0, @@ -829028,11 +832183,11 @@ }, { "sim":242.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":242.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":240.0, @@ -829138,10 +832293,6 @@ "sim":228.0, "partner":"4hrn" }, - { - "sim":228.0, - "partner":"7pd8" - }, { "sim":228.0, "partner":"7pdd" @@ -829154,6 +832305,10 @@ "sim":228.0, "partner":"7pdh" }, + { + "sim":228.0, + "partner":"7pd8" + }, { "sim":224.0, "partner":"6moj" @@ -829292,23 +832447,23 @@ }, { "sim":119.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":119.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":119.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":119.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":119.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":119.0, @@ -829316,11 +832471,11 @@ }, { "sim":119.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":119.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":119.0, @@ -829394,10 +832549,6 @@ "sim":103.0, "partner":"2l6b" }, - { - "sim":103.0, - "partner":"5vhj" - }, { "sim":103.0, "partner":"5vhh" @@ -829428,15 +832579,15 @@ }, { "sim":103.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":103.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":103.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":103.0, @@ -829446,6 +832597,10 @@ "sim":103.0, "partner":"7vxw" }, + { + "sim":103.0, + "partner":"1uoh" + }, { "sim":103.0, "partner":"7vy4" @@ -829456,11 +832611,11 @@ }, { "sim":103.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":103.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":103.0, @@ -829472,15 +832627,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":102.0, @@ -829520,11 +832675,11 @@ }, { "sim":102.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":102.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":100.0, @@ -829552,11 +832707,11 @@ }, { "sim":99.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":99.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":99.0, @@ -829636,15 +832791,15 @@ }, { "sim":91.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":91.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":91.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":91.0, @@ -829664,16 +832819,24 @@ }, { "sim":90.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":90.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":90.0, "partner":"7roy" }, + { + "sim":90.0, + "partner":"8wqg" + }, + { + "sim":90.0, + "partner":"8wqe" + }, { "sim":90.0, "partner":"8wqh" @@ -829702,14 +832865,6 @@ "sim":90.0, "partner":"8wqd" }, - { - "sim":90.0, - "partner":"8wqg" - }, - { - "sim":90.0, - "partner":"8wqe" - }, { "sim":90.0, "partner":"8je1" @@ -829846,10 +833001,6 @@ "sim":84.0, "partner":"6e2g" }, - { - "sim":84.0, - "partner":"6v9x" - }, { "sim":84.0, "partner":"6v9y" @@ -829862,6 +833013,10 @@ "sim":84.0, "partner":"6v9w" }, + { + "sim":84.0, + "partner":"6v9x" + }, { "sim":84.0, "partner":"7or0" @@ -829982,10 +833137,6 @@ "sim":80.0, "partner":"5wo6" }, - { - "sim":80.0, - "partner":"5iwr" - }, { "sim":80.0, "partner":"5iwt" @@ -830040,11 +833191,11 @@ }, { "sim":80.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":80.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":80.0, @@ -830084,11 +833235,7 @@ }, { "sim":80.0, - "partner":"7t6m" - }, - { - "sim":80.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":80.0, @@ -830124,15 +833271,19 @@ }, { "sim":80.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":80.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":80.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":80.0, + "partner":"7t6k" }, { "sim":80.0, @@ -830140,7 +833291,7 @@ }, { "sim":80.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":80.0, @@ -830148,7 +833299,11 @@ }, { "sim":80.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":80.0, + "partner":"8ffn" }, { "sim":79.0, @@ -830162,14 +833317,6 @@ "sim":79.0, "partner":"6kyk" }, - { - "sim":78.0, - "partner":"3aaa" - }, - { - "sim":78.0, - "partner":"7dsb" - }, { "sim":78.0, "partner":"7df7" @@ -830180,15 +833327,15 @@ }, { "sim":78.0, - "partner":"2he0" + "partner":"7dsb" }, { "sim":78.0, - "partner":"6m11" + "partner":"3aaa" }, { "sim":78.0, - "partner":"6m12" + "partner":"2he0" }, { "sim":78.0, @@ -830214,6 +833361,14 @@ "sim":78.0, "partner":"4o1p" }, + { + "sim":78.0, + "partner":"6m11" + }, + { + "sim":78.0, + "partner":"6m12" + }, { "sim":78.0, "partner":"6aun" @@ -830292,11 +833447,11 @@ }, { "sim":74.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":74.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":74.0, @@ -830322,10 +833477,6 @@ "sim":73.0, "partner":"8sp8" }, - { - "sim":73.0, - "partner":"7k4a" - }, { "sim":73.0, "partner":"7k4b" @@ -830348,7 +833499,7 @@ }, { "sim":73.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":73.0, @@ -830364,7 +833515,7 @@ }, { "sim":73.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":73.0, @@ -830376,7 +833527,7 @@ }, { "sim":73.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":73.0, @@ -830394,6 +833545,10 @@ "sim":73.0, "partner":"6bo8" }, + { + "sim":73.0, + "partner":"6bo9" + }, { "sim":72.0, "partner":"1bi7" @@ -830436,15 +833591,15 @@ }, { "sim":68.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":68.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":68.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":68.0, @@ -830604,19 +833759,19 @@ }, { "sim":50.0, - "partner":"8u43" + "partner":"8u2z" }, { "sim":50.0, - "partner":"8u4d" + "partner":"8u43" }, { "sim":50.0, - "partner":"8u3a" + "partner":"8u4d" }, { "sim":50.0, - "partner":"8u2z" + "partner":"8u3a" }, { "sim":50.0, @@ -830630,18 +833785,10 @@ "sim":50.0, "partner":"5is0" }, - { - "sim":50.0, - "partner":"7mzc" - }, { "sim":50.0, "partner":"7l2v" }, - { - "sim":50.0, - "partner":"8t3l" - }, { "sim":50.0, "partner":"7mzd" @@ -830652,7 +833799,7 @@ }, { "sim":50.0, - "partner":"8t3m" + "partner":"8t3l" }, { "sim":50.0, @@ -830670,6 +833817,10 @@ "sim":50.0, "partner":"7l2x" }, + { + "sim":50.0, + "partner":"8t3m" + }, { "sim":50.0, "partner":"7l2r" @@ -830704,35 +833855,35 @@ }, { "sim":50.0, - "partner":"8t0y" + "partner":"7mzc" }, { "sim":50.0, - "partner":"8u3l" + "partner":"8t0y" }, { "sim":50.0, - "partner":"8t0c" + "partner":"8u30" }, { "sim":50.0, - "partner":"8u30" + "partner":"8u3c" }, { "sim":50.0, - "partner":"8t0e" + "partner":"8t0c" }, { "sim":50.0, - "partner":"8t10" + "partner":"8t0e" }, { "sim":50.0, - "partner":"8u3c" + "partner":"8t10" }, { "sim":50.0, - "partner":"7l2n" + "partner":"8u3l" }, { "sim":50.0, @@ -830768,32 +833919,28 @@ }, { "sim":50.0, - "partner":"7lqy" + "partner":"7l2n" }, { "sim":50.0, - "partner":"7lqz" + "partner":"7lqy" }, { "sim":50.0, - "partner":"7lr0" + "partner":"7lqz" }, { "sim":50.0, - "partner":"7lpd" + "partner":"7lr0" }, { "sim":50.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":50.0, "partner":"7rqv" }, - { - "sim":50.0, - "partner":"7lpe" - }, { "sim":50.0, "partner":"7rqw" @@ -830825,6 +833972,14 @@ { "sim":50.0, "partner":"7lpc" + }, + { + "sim":50.0, + "partner":"7rqu" + }, + { + "sim":50.0, + "partner":"7lpd" } ], "struct_thr_sim_designed":[ @@ -831033,11 +834188,11 @@ ], "seq_max_sim_designed":{ "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, "seq_max_sim_natural":{ "sim":342.0, - "partner":"7yz0" + "partner":"6mzf" }, "struct_max_sim_designed":{ "sim":0.9995999932, @@ -831095,103 +834250,103 @@ ], "subtitle":"L2 forming rubisco derived from ancestral sequence reconstruction of the last common ancestor of form i'' and form i rubiscos", "tags":[ - "ancestral", - "cabp", "rubisco", - "lyase" + "cabp", + "lyase", + "ancestral" ], "keywords":[ - "work", - "evolution", - "long", - "layering", - "multiple", + "show", "complexes", - "abundant", - "proposed", + "multiple", + "precursor", "substitutions", - "show", - "broadly", - "catalysis", - "even", - "interaction", - "reverts", - "composed", - "proteins", - "gradual", - "enzyme", - "persistence", - "ancestral", - "easily", - "nature", - "evolutionary", - "often", - "essentiality", - "arise", - "tolerated", + "newly", + "explain", "lead", - "genetically", + "framework", + "partner", + "affect", + "solubility", + "new", + "start", + "protein", + "ago", + "accumulation", + "given", + "changes", + "essential", + "demonstrate", + "composed", "photosynthesis", + "persist", "cause", - "essential", - "theoretical", - "recruited", "areas", - "affect", - "highlights", - "stability", - "framework", - "accumulation", - "drastically", - "newly", - "components", - "factors", + "complex", + "mechanisms", "timescales", - "changes", - "exploration", - "complexification", - "would", + "accessible", + "factors", "deleterious", - "partner", + "stability", + "proteins", + "essentiality", + "recruited", + "ancestral", "standalone", - "persist", - "sequence", + "enzyme", + "components", "subunits", - "start", + "evolution", + "strictly", + "tolerated", + "long", "unclear", - "solubility", - "demonstrate", - "accessible", - "ago", - "rubisco", - "state", - "new", - "central", + "theoretical", + "work", + "even", + "highlights", + "arise", + "easily", + "persistence", + "interaction", + "broadly", + "sequence", "mechanism", - "explain", + "proposed", + "catalysis", + "evolutionary", + "multilayered", "partners", - "protein", - "strictly", - "given", - "complex", - "mechanisms", + "central", + "often", + "complexification", "space", - "arises", + "reverts", + "gradual", + "state", + "exploration", + "nature", + "would", + "genetically", + "drastically", + "abundant", "distinct", - "precursor", + "rubisco", + "arises", "depend", - "multilayered" + "layering" ], "release_date":"2024-10-16", - "publication":"\"Layered entrenchment maintains essentiality in the evolution of Form I Rubisco complexes\", Biorxiv", + "publication":"\"Layered entrenchment maintains essentiality in the evolution of Form I Rubisco complexes\", Embo J., 44, 269-280", "publication_ref":{ - "DOI":"10.1101\/2024.01.18.576253", - "PubMed":"", - "CSD":"", - "ISSN":"2692-8205", - "ASTM":"" + "DOI":"10.1038\/s44318-024-00311-1", + "PubMed":"39558108", + "CSD":"0897", + "ISSN":"1460-2075", + "ASTM":"EMJODG" }, - "publication_country":"US", + "publication_country":"UK", "abstract":"Protein complexes composed of strictly essential subunits are abundant in nature and often arise through the gradual complexification of ancestral precursor proteins. Essentiality can arise through the accumulation of changes that are tolerated in the complex state but would be deleterious for the standalone complex components. While this theoretical framework to explain how essentiality arises has been proposed long ago, it is unclear which factors cause essentiality to persist over evolutionary timescales. In this work we show that the central enzyme of photosynthesis, ribulose-1,5-bisphosphate carboxylase\/oxygenase (Rubisco), can easily start to depend on a newly recruited interaction partner through multiple, genetically distinct mechanisms that affect stability, solubility, and catalysis. We demonstrate that layering multiple mechanisms of essentiality can lead to its persistence, even if any given mechanism reverts. More broadly, our work highlights that new interaction partners can drastically re-shape which substitutions are tolerated in the proteins they are recruited into. This can lead to the evolution of multilayered essentiality through the exploration of areas of sequence space that are only accessible in the complex state.", "crystal_structure":{ "length_a":"121.790", @@ -831217,11 +834372,11 @@ }, { "sim":937.0, - "partner":"7qsy" + "partner":"7qsx" }, { "sim":937.0, - "partner":"7qsx" + "partner":"7qsy" }, { "sim":936.0, @@ -831229,11 +834384,11 @@ }, { "sim":935.0, - "partner":"7qt1" + "partner":"7qsz" }, { "sim":935.0, - "partner":"7qsz" + "partner":"7qt1" }, { "sim":919.0, @@ -831267,39 +834422,39 @@ }, { "sim":677.0, - "partner":"2wvw" + "partner":"8ioj" }, { "sim":677.0, - "partner":"8ilb" + "partner":"8wpz" }, { "sim":677.0, - "partner":"8ilm" + "partner":"6hbc" }, { "sim":677.0, - "partner":"8wpz" + "partner":"8bcm" }, { "sim":677.0, - "partner":"8ioj" + "partner":"1rsc" }, { "sim":677.0, - "partner":"1rsc" + "partner":"8iol" }, { "sim":677.0, - "partner":"6hbc" + "partner":"8ilm" }, { "sim":677.0, - "partner":"8bcm" + "partner":"8ilb" }, { "sim":677.0, - "partner":"8iol" + "partner":"2wvw" }, { "sim":677.0, @@ -831309,10 +834464,6 @@ "sim":677.0, "partner":"6lrs" }, - { - "sim":677.0, - "partner":"6z1f" - }, { "sim":677.0, "partner":"6z1g" @@ -831325,6 +834476,10 @@ "sim":677.0, "partner":"7xsd" }, + { + "sim":677.0, + "partner":"6z1f" + }, { "sim":677.0, "partner":"6kkm" @@ -831387,11 +834542,11 @@ }, { "sim":648.0, - "partner":"8q05" + "partner":"8q04" }, { "sim":648.0, - "partner":"8q04" + "partner":"8q05" }, { "sim":646.0, @@ -831423,23 +834578,23 @@ }, { "sim":644.0, - "partner":"2vdh" + "partner":"1upm" }, { "sim":644.0, - "partner":"1upm" + "partner":"8ruc" }, { "sim":644.0, - "partner":"8qj0" + "partner":"1upp" }, { "sim":644.0, - "partner":"1upp" + "partner":"8qj0" }, { "sim":644.0, - "partner":"8ruc" + "partner":"2vdh" }, { "sim":644.0, @@ -831447,16 +834602,12 @@ }, { "sim":643.0, - "partner":"7jn4" + "partner":"2v69" }, { "sim":643.0, "partner":"7jsx" }, - { - "sim":643.0, - "partner":"2v69" - }, { "sim":643.0, "partner":"1ir2" @@ -831467,11 +834618,11 @@ }, { "sim":643.0, - "partner":"1gk8" + "partner":"7jfo" }, { "sim":643.0, - "partner":"7jfo" + "partner":"1gk8" }, { "sim":643.0, @@ -831482,13 +834633,17 @@ "partner":"1uzd" }, { - "sim":642.0, - "partner":"1aus" + "sim":643.0, + "partner":"7jn4" }, { "sim":642.0, "partner":"1uwa" }, + { + "sim":642.0, + "partner":"1aus" + }, { "sim":642.0, "partner":"1rxo" @@ -831567,15 +834722,15 @@ }, { "sim":550.0, - "partner":"4f0k" + "partner":"4f0m" }, { "sim":550.0, - "partner":"4f0m" + "partner":"4f0h" }, { "sim":550.0, - "partner":"4f0h" + "partner":"4f0k" }, { "sim":541.0, @@ -831595,11 +834750,11 @@ }, { "sim":524.0, - "partner":"7yk5" + "partner":"5n9z" }, { "sim":524.0, - "partner":"5n9z" + "partner":"7yk5" }, { "sim":371.0, @@ -831627,11 +834782,11 @@ }, { "sim":318.0, - "partner":"3kdn" + "partner":"3a13" }, { "sim":318.0, - "partner":"3a13" + "partner":"3kdn" }, { "sim":317.0, @@ -831667,15 +834822,15 @@ }, { "sim":190.0, - "partner":"5hjx" + "partner":"4lf1" }, { "sim":190.0, - "partner":"4lf1" + "partner":"4lf2" }, { "sim":190.0, - "partner":"4lf2" + "partner":"5hjx" }, { "sim":190.0, @@ -831699,11 +834854,11 @@ }, { "sim":183.0, - "partner":"7vwx" + "partner":"9rub" }, { "sim":183.0, - "partner":"9rub" + "partner":"7vwx" }, { "sim":183.0, @@ -831739,11 +834894,11 @@ }, { "sim":148.0, - "partner":"1ykw" + "partner":"1tel" }, { "sim":148.0, - "partner":"1tel" + "partner":"1ykw" }, { "sim":145.0, @@ -831763,15 +834918,15 @@ }, { "sim":131.0, - "partner":"2oel" + "partner":"2oek" }, { "sim":131.0, - "partner":"2oem" + "partner":"2oel" }, { "sim":131.0, - "partner":"2oek" + "partner":"2oem" }, { "sim":122.0, @@ -831837,10 +834992,6 @@ "sim":0.9546999931, "partner":"1wdd" }, - { - "sim":0.9613000154, - "partner":"6ura" - }, { "sim":0.9595999718, "partner":"1rbo" @@ -831854,8 +835005,8 @@ "partner":"2v67" }, { - "sim":0.9573000073, - "partner":"2v68" + "sim":0.9613000154, + "partner":"6ura" }, { "sim":0.9528999925, @@ -831866,24 +835017,28 @@ "partner":"1uwa" }, { - "sim":0.9559999704, - "partner":"1uw9" + "sim":0.9524999857, + "partner":"2v6a" }, { - "sim":0.954400003, - "partner":"1gk8" + "sim":0.9573000073, + "partner":"2v68" }, { - "sim":0.9524999857, - "partner":"2v6a" + "sim":0.9514999986, + "partner":"2vdi" }, { "sim":0.9559999704, "partner":"1upm" }, { - "sim":0.9514999986, - "partner":"2vdi" + "sim":0.954400003, + "partner":"1gk8" + }, + { + "sim":0.9559999704, + "partner":"1uw9" }, { "sim":0.9501000047, @@ -831944,13 +835099,13 @@ "forename":"W.", "surname":"Steinchen" }, - { - "forename":"T.J.", - "surname":"Erb" - }, { "forename":"G.K.A.", "surname":"Hochberg" + }, + { + "forename":"T.J.", + "surname":"Erb" } ], "classification":"unknown", @@ -831962,98 +835117,98 @@ ], "subtitle":"Non-obligately l8s8-complex forming rubisco derived from ancestral sequence reconstruction and rational engineering in l8s8 complex with substitutions r269w, e271r, l273n", "tags":[ - "ancestral", - "cabp", "rubisco", - "lyase" + "cabp", + "lyase", + "ancestral" ], "keywords":[ - "work", - "evolution", - "long", - "layering", - "multiple", + "show", "complexes", - "abundant", - "proposed", + "multiple", + "precursor", "substitutions", - "show", - "broadly", - "catalysis", - "even", - "interaction", - "reverts", - "composed", - "proteins", - "gradual", - "enzyme", - "persistence", - "ancestral", - "easily", - "nature", - "evolutionary", - "often", - "essentiality", - "arise", - "tolerated", + "newly", + "explain", "lead", - "genetically", + "framework", + "partner", + "affect", + "solubility", + "new", + "start", + "protein", + "ago", + "accumulation", + "given", + "changes", + "essential", + "demonstrate", + "composed", "photosynthesis", + "persist", "cause", - "essential", - "theoretical", - "recruited", "areas", - "affect", - "highlights", - "stability", - "framework", - "accumulation", - "drastically", - "newly", - "components", - "factors", + "complex", + "mechanisms", "timescales", - "changes", - "exploration", - "complexification", - "would", + "accessible", + "factors", "deleterious", - "partner", + "stability", + "proteins", + "essentiality", + "recruited", + "ancestral", "standalone", - "persist", - "sequence", + "enzyme", + "components", "subunits", - "start", + "evolution", + "strictly", + "tolerated", + "long", "unclear", - "solubility", - "demonstrate", - "accessible", - "ago", - "rubisco", - "state", - "new", - "central", + "theoretical", + "work", + "even", + "highlights", + "arise", + "easily", + "persistence", + "interaction", + "broadly", + "sequence", "mechanism", - "explain", + "proposed", + "catalysis", + "evolutionary", + "multilayered", "partners", - "protein", - "strictly", - "given", - "complex", - "mechanisms", + "central", + "often", + "complexification", "space", - "arises", + "reverts", + "gradual", + "state", + "exploration", + "nature", + "would", + "genetically", + "drastically", + "abundant", "distinct", - "precursor", + "rubisco", + "arises", "depend", - "multilayered" + "layering" ], "release_date":"2024-10-02", - "publication":"\"Layered entrenchment maintains essentiality in protein-protein interactions\", Embo J.", + "publication":"\"Layered entrenchment maintains essentiality in the evolution of Form I Rubisco complexes\", Embo J., 44, 269-280", "publication_ref":{ - "DOI":"", - "PubMed":"", + "DOI":"10.1038\/s44318-024-00311-1", + "PubMed":"39558108", "CSD":"0897", "ISSN":"1460-2075", "ASTM":"EMJODG" @@ -832078,14 +835233,14 @@ "previous_design":"8qmv", "next_design":"8qtq", "seq_thr_sim_designed":[ - { - "sim":935.0, - "partner":"7qt1" - }, { "sim":782.0, "partner":"7qsw" }, + { + "sim":935.0, + "partner":"7qt1" + }, { "sim":937.0, "partner":"7qsy" @@ -832134,39 +835289,39 @@ }, { "sim":677.0, - "partner":"2wvw" + "partner":"8ioj" }, { "sim":677.0, - "partner":"8ilb" + "partner":"8wpz" }, { "sim":677.0, - "partner":"8ilm" + "partner":"6hbc" }, { "sim":677.0, - "partner":"8wpz" + "partner":"8bcm" }, { "sim":677.0, - "partner":"8ioj" + "partner":"1rsc" }, { "sim":677.0, - "partner":"1rsc" + "partner":"8iol" }, { "sim":677.0, - "partner":"6hbc" + "partner":"8ilm" }, { "sim":677.0, - "partner":"8bcm" + "partner":"8ilb" }, { "sim":677.0, - "partner":"8iol" + "partner":"2wvw" }, { "sim":677.0, @@ -832176,10 +835331,6 @@ "sim":677.0, "partner":"6lrs" }, - { - "sim":677.0, - "partner":"6z1f" - }, { "sim":677.0, "partner":"6z1g" @@ -832192,6 +835343,10 @@ "sim":677.0, "partner":"7xsd" }, + { + "sim":677.0, + "partner":"6z1f" + }, { "sim":677.0, "partner":"6kkm" @@ -832254,11 +835409,11 @@ }, { "sim":648.0, - "partner":"8q05" + "partner":"8q04" }, { "sim":648.0, - "partner":"8q04" + "partner":"8q05" }, { "sim":646.0, @@ -832290,23 +835445,23 @@ }, { "sim":644.0, - "partner":"2vdh" + "partner":"1upm" }, { "sim":644.0, - "partner":"1upm" + "partner":"8ruc" }, { "sim":644.0, - "partner":"8qj0" + "partner":"1upp" }, { "sim":644.0, - "partner":"1upp" + "partner":"8qj0" }, { "sim":644.0, - "partner":"8ruc" + "partner":"2vdh" }, { "sim":644.0, @@ -832314,16 +835469,12 @@ }, { "sim":643.0, - "partner":"7jn4" + "partner":"2v69" }, { "sim":643.0, "partner":"7jsx" }, - { - "sim":643.0, - "partner":"2v69" - }, { "sim":643.0, "partner":"1ir2" @@ -832334,11 +835485,11 @@ }, { "sim":643.0, - "partner":"1gk8" + "partner":"7jfo" }, { "sim":643.0, - "partner":"7jfo" + "partner":"1gk8" }, { "sim":643.0, @@ -832349,13 +835500,17 @@ "partner":"1uzd" }, { - "sim":642.0, - "partner":"1aus" + "sim":643.0, + "partner":"7jn4" }, { "sim":642.0, "partner":"1uwa" }, + { + "sim":642.0, + "partner":"1aus" + }, { "sim":642.0, "partner":"1rxo" @@ -832434,15 +835589,15 @@ }, { "sim":550.0, - "partner":"4f0k" + "partner":"4f0m" }, { "sim":550.0, - "partner":"4f0m" + "partner":"4f0h" }, { "sim":550.0, - "partner":"4f0h" + "partner":"4f0k" }, { "sim":541.0, @@ -832462,11 +835617,11 @@ }, { "sim":524.0, - "partner":"7yk5" + "partner":"5n9z" }, { "sim":524.0, - "partner":"5n9z" + "partner":"7yk5" }, { "sim":371.0, @@ -832494,11 +835649,11 @@ }, { "sim":318.0, - "partner":"3kdn" + "partner":"3a13" }, { "sim":318.0, - "partner":"3a13" + "partner":"3kdn" }, { "sim":317.0, @@ -832534,15 +835689,15 @@ }, { "sim":190.0, - "partner":"5hjx" + "partner":"4lf1" }, { "sim":190.0, - "partner":"4lf1" + "partner":"4lf2" }, { "sim":190.0, - "partner":"4lf2" + "partner":"5hjx" }, { "sim":190.0, @@ -832566,11 +835721,11 @@ }, { "sim":183.0, - "partner":"7vwx" + "partner":"9rub" }, { "sim":183.0, - "partner":"9rub" + "partner":"7vwx" }, { "sim":183.0, @@ -832606,11 +835761,11 @@ }, { "sim":148.0, - "partner":"1ykw" + "partner":"1tel" }, { "sim":148.0, - "partner":"1tel" + "partner":"1ykw" }, { "sim":145.0, @@ -832630,15 +835785,15 @@ }, { "sim":131.0, - "partner":"2oel" + "partner":"2oek" }, { "sim":131.0, - "partner":"2oem" + "partner":"2oel" }, { "sim":131.0, - "partner":"2oek" + "partner":"2oem" }, { "sim":122.0, @@ -832658,6 +835813,10 @@ "sim":0.9995999932, "partner":"7qt1" }, + { + "sim":0.9994999766, + "partner":"7qsw" + }, { "sim":0.9972000122, "partner":"7qsy" @@ -832666,14 +835825,14 @@ "sim":0.9965999722, "partner":"8qmv" }, - { - "sim":0.994599998, - "partner":"7qsz" - }, { "sim":0.9919000268, "partner":"7qsv" }, + { + "sim":0.994599998, + "partner":"7qsz" + }, { "sim":0.9965999722, "partner":"7qsx" @@ -832681,10 +835840,6 @@ { "sim":0.972299993, "partner":"7qvi" - }, - { - "sim":0.9994999766, - "partner":"7qsw" } ], "struct_thr_sim_natural":[ @@ -832837,108 +835992,108 @@ ], "subtitle":"Thermostable ww domain", "tags":[ - "structural protein", - "ww domain fold de novo design" + "ww domain fold de novo design", + "structural protein" ], "keywords":[ - "thermal", - "domain", - "results", - "providing", - "thus", - "thermostability", - "modes", - "metal", - "scaffolds", - "peptide", - "temperatures", - "features", - "synthetic", - "display", - "intended", - "applied", - "thermostable", - "identification", - "34", - "discrete", - "k", - "de", - "indeed", + "superior", "finally", - "grafted", - "used", - "highly", - "serve", - "motif", - "onto", + "structural", "scale", - "positions", - "material", - "atomic", - "particular", + "thermostable", + "core", + "group", "three", - "organophosphate", + "affect", + "results", + "folding", + "positions", + "decipher", + "binding", + "motif", "essential", - "biology", + "novo", + "domains", + "demonstrate", "motifs", - "exhibit", - "affect", - "contribute", - "performed", - "reliably", + "recent", + "k", "predictably", - "consensus", - "rounds", - "platform", - "properties", - "previously", - "stability", - "decipher", - "reported", + "temperatures", + "material", + "chemistry", "toolbox", - "obtained", - "yields", - "functional", - "group", - "higher", - "surge", - "article", - "temperature", - "medicinal", + "metal", "interest", + "modes", + "thus", + "identified", + "enabled", "specific", - "ww", - "design", - "melting", - "core", - "present", - "biomaterial", - "nmr", - "recent", - "high", - "sequence", - "structural", - "impressively", - "demonstrate", - "designs", - "chemistry", - "novo", + "thermal", + "intended", + "organophosphate", + "stability", + "rounds", + "reliably", + "consensus", + "34", + "scaffold", + "highly", + "higher", + "features", "iteration", - "90", - "fold", + "peptide", + "discrete", + "obtained", "solid", + "exhibit", + "design", + "miniproteins", + "onto", + "indeed", + "atomic", "spectroscopy", + "used", + "biology", + "functional", + "display", + "domain", "different", - "identified", + "properties", + "platform", + "fold", "addition", - "scaffold", - "domains", - "superior", + "impressively", + "medicinal", + "biomaterial", + "90", + "sequence", + "applied", + "reported", "relationship", - "enabled", - "folding", - "binding", - "miniproteins" + "present", + "article", + "grafted", + "particular", + "identification", + "providing", + "de", + "surge", + "yields", + "ww", + "performed", + "previously", + "contribute", + "synthetic", + "thermostability", + "scaffolds", + "serve", + "temperature", + "nmr", + "melting", + "high", + "designs" ], "release_date":"2024-07-03", "publication":"\"Thermostable WW-Domain Scaffold to Design Functional beta-Sheet Miniproteins\", J.Am.Chem.Soc.", @@ -833036,14 +836191,6 @@ "sim":51.0, "partner":"1i6c" }, - { - "sim":51.0, - "partner":"2zr4" - }, - { - "sim":51.0, - "partner":"2zr5" - }, { "sim":51.0, "partner":"2zqs" @@ -833080,6 +836227,14 @@ "sim":51.0, "partner":"6o33" }, + { + "sim":51.0, + "partner":"2zr4" + }, + { + "sim":51.0, + "partner":"2zr5" + }, { "sim":51.0, "partner":"6vaj" @@ -833192,11 +836347,11 @@ }, { "sim":71.0, - "partner":"1cd9" + "partner":"1pgr" }, { "sim":71.0, - "partner":"1pgr" + "partner":"1cd9" }, { "sim":71.0, @@ -833301,7 +836456,7 @@ }, { "forename":"R.", - "surname":"Jimenez-Perez" + "surname":"Perez-Jimenez" } ], "classification":"unknown", @@ -833313,107 +836468,107 @@ ], "subtitle":"Apo rechb", "tags":[ + "biosynthetic protein", "cryo-em", "cas", "ancestral sequence reconstruction", - "biotechnology", - "biosynthetic protein" + "biotechnology" ], "keywords":[ - "details", - "53", + "substrates", + "technologies", + "finally", + "constrict", + "molecular", + "recognition", + "activators", + "pam", + "crispr", + "three", "acid", - "efficiencies", - "requires", - "potential", - "reconstruction", - "applied", - "genome", - "quaternary", - "achieve", - "enascas12a", - "triggered", + "details", + "study", + "activities", + "collateral", + "electron", + "microscopy", + "cleavage", + "cells", "closest", - "ortholog", - "longer", - "constrict", - "dna", + "applications", "similar", - "technologies", - "characterized", - "finally", + "tertiary", + "achieve", "cas12a", - "pam", - "expands", - "ancestral", - "recognition", + "engineered", + "characterized", + "ortholog", + "enascas12a", + "editing", "furthermore", - "reconstruct", - "collateral", - "structures", - "natural", + "rna", + "dna", + "overall", + "accessible", + "targets", "asr", - "three", - "orthologs", - "tertiary", - "crispr", + "quaternary", + "efficiencies", + "sites", "hydrobacteria", - "targeting", - "properties", + "ancestral", + "inaccessible", + "reconstruct", + "longer", + "set", "obtained", - "substrates", - "cleavage", - "molecular", "identity", - "rechb", - "editing", - "common", - "activators", - "rna", - "activities", - "inaccessible", + "expanded", + "diverse", + "expands", + "natural", + "potential", + "properties", + "cryogenic", + "targeting", "application", - "applications", + "also", + "orthologs", + "enhancing", + "underscores", + "nucleic", + "leading", "underlying", + "applied", "sequence", - "ancestor", - "cells", - "nucleases", + "requires", + "common", "range", - "sites", - "diverse", - "overall", - "accessible", - "nucleic", - "also", - "underscores", - "study", - "human", - "electron", - "engineered", + "fncas12a", "reveal", - "leading", - "enhancing", - "set", - "microscopy", - "targets", - "shares", + "genome", "space", - "fncas12a", - "expanded", - "cryogenic", - "biophysical" + "structures", + "reconstruction", + "nucleases", + "biophysical", + "53", + "ancestor", + "triggered", + "shares", + "human", + "rechb" ], "release_date":"2024-10-02", - "publication":"\"A resurrected ancestor of Cas12a expands target access and substrate 2 recognition for nucleic-acid editing and detection\", Nature Biotechnology", + "publication":"\"A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection\", Nat.Biotechnol.", "publication_ref":{ - "DOI":"", - "PubMed":"", - "CSD":"", - "ISSN":"", - "ASTM":"" + "DOI":"10.1038\/s41587-024-02461-3", + "PubMed":"39482449", + "CSD":"2119", + "ISSN":"1087-0156", + "ASTM":"NABIF9" }, - "publication_country":"", + "publication_country":"US", "abstract":"The properties of Cas12a nucleases constrict the range of accessible targets and their applications. In this study, we applied ancestral sequence reconstruction (ASR) to a set of Cas12a orthologs from hydrobacteria to reconstruct a common ancestor, ReChb, characterized by near-PAMless targeting and the recognition of diverse nucleic acid activators and collateral substrates. ReChb shares 53% sequence identity with the closest Cas12a ortholog but no longer requires a T-rich PAM and can achieve genome editing in human cells at sites inaccessible to the natural FnCas12a or the engineered and PAM-flexible enAsCas12a. Furthermore, ReChb can be triggered not only by double-stranded DNA but also by single-stranded RNA and DNA targets, leading to non-specific collateral cleavage of all three nucleic acid substrates with similar efficiencies. Finally, tertiary and quaternary structures of ReChb obtained by cryogenic electron microscopy reveal the molecular details underlying its expanded biophysical activities. Overall, ReChb expands the application space of Cas12a nucleases and underscores the potential of ASR for enhancing CRISPR technologies.", "crystal_structure":{ "length_a":"1.00", @@ -833496,10 +836651,6 @@ "sim":1204.0, "partner":"8i54" }, - { - "sim":1141.0, - "partner":"6nmd" - }, { "sim":1141.0, "partner":"6nme" @@ -833522,7 +836673,7 @@ }, { "sim":1141.0, - "partner":"6klb" + "partner":"6nmd" }, { "sim":1141.0, @@ -833530,16 +836681,20 @@ }, { "sim":1141.0, - "partner":"5xuz" + "partner":"6klb" }, { "sim":1141.0, - "partner":"5xus" + "partner":"5xuz" }, { "sim":1141.0, "partner":"6p7m" }, + { + "sim":1141.0, + "partner":"5xus" + }, { "sim":1141.0, "partner":"5xut" @@ -833614,15 +836769,15 @@ }, { "sim":68.0, - "partner":"8d4a" + "partner":"8d4b" }, { "sim":68.0, - "partner":"8d4b" + "partner":"8d49" }, { "sim":68.0, - "partner":"8d49" + "partner":"8d4a" } ], "struct_thr_sim_designed":[ @@ -833702,118 +836857,118 @@ "hydrolase" ], "keywords":[ - "overcoming", - "results", - "restricted", - "architecture", - "use", - "hallucination", - "strategy", - "reducing", - "scaffolds", - "lacking", - "expressed", + "290", + "engineering", + "molecular", + "recognition", "glycoside", - "designed", - "prediction", - "indispensable", - "11", "methods", - "experimentally", - "crystal", - "determined", - "potential", - "catalytically", - "designing", - "structure", + "gh101", + "side", + "deviation", + "within", + "intricate", + "results", + "strategy", + "overcoming", + "six", + "increased", "representative", - "trrosetta", - "hydrolase", - "proteins", + "sources", + "site", + "novo", + "weight", + "subsequent", + "applications", + "recent", + "crystal", + "chains", + "100", + "using", "similar", - "de", - "enzymes", + "biocatalysts", + "initial", + "soluble", + "hallucination", + "experimentally", + "enabled", + "specific", "family", - "\u00e5", + "matched", + "derived", + "stability", + "sites", + "proteins", + "detectable", + "use", + "enzymes", + "architecture", + "success", + "may", + "scaffold", "enzyme", - "substrate", - "kda", - "serve", - "yet", - "recognition", - "initial", - "often", - "thermostabilities", + "reducing", + "iterative", + "restricted", + "computational", + "importance", + "combination", + "advantageous", + "proteinmpnn", + "11", + "designing", + "advances", "highlight", - "structures", - "numerous", - "290", - "derived", - "foundation", - "natural", + "catalytically", + "design", "compared", - "stability", - "monomers", - "100", - "molecular", + "active", + "platforms", + "natural", "functional", + "substrate", + "yet", + "potential", + "tested", + "monomers", + "n", + "prediction", + "selectivity", "amino", - "subsequent", "industrial", - "biocatalysts", - "increased", - "acids", - "limitations", - "may", - "simplified", - "active", - "closely", - "specific", - "advances", - "activity", - "engineering", - "six", + "kda", + "trrosetta", + "thermostabilities", + "incorporating", + "foundation", "challenged", - "platforms", - "design", - "iterative", - "weight", - "soluble", - "using", - "present", - "applications", - "recent", - "detectable", "sequence", - "gh101", + "simplified", + "numerous", + "present", + "indispensable", + "cycles", + "designed", + "often", + "displaying", + "structures", + "de", + "expressed", + "\u00e5", + "enzymatic", + "structure", "important", - "sites", - "advantageous", - "importance", - "designs", + "scaffolds", + "determined", + "serve", + "closely", + "hydrolase", + "activity", + "lacking", + "acids", "despite", - "chains", - "tested", - "proteinmpnn", - "n", - "novo", - "success", - "matched", - "enzymatic", - "deviation", - "displaying", - "selectivity", - "intricate", - "cycles", - "incorporating", - "scaffold", - "combination", - "within", - "computational", - "enabled", - "side", - "site", - "sources" + "limitations", + "designs" ], "release_date":"2024-03-06", "publication":"\"Carving out a Glycoside Hydrolase Active Site for Incorporation into a New Protein Scaffold Using Deep Network Hallucination\", Acs Synth Biol, 13, 862-875", @@ -833911,11 +837066,11 @@ ], "subtitle":"Crystal structure of borneoldehydrogenase ancestor n32", "tags":[ + "rossmann-like fold", "alcohol", - "terpenoid", + "oxidoreductase", "borneol", - "rossmann-like fold", - "oxidoreductase" + "terpenoid" ], "keywords":[ "description", @@ -833960,11 +837115,11 @@ }, { "sim":51.0, - "partner":"8v2w" + "partner":"8v09" }, { "sim":51.0, - "partner":"8v09" + "partner":"8v2w" }, { "sim":50.0, @@ -834062,11 +837217,11 @@ }, { "sim":145.0, - "partner":"6ixm" + "partner":"5x8h" }, { "sim":145.0, - "partner":"5x8h" + "partner":"6ixm" }, { "sim":144.0, @@ -834102,7 +837257,7 @@ }, { "sim":141.0, - "partner":"5tii" + "partner":"5thq" }, { "sim":141.0, @@ -834110,7 +837265,7 @@ }, { "sim":141.0, - "partner":"5thq" + "partner":"5tii" }, { "sim":140.0, @@ -834146,19 +837301,19 @@ }, { "sim":138.0, - "partner":"6pei" + "partner":"6pej" }, { "sim":138.0, - "partner":"6pej" + "partner":"6pei" }, { "sim":136.0, - "partner":"8y7r" + "partner":"8y83" }, { "sim":136.0, - "partner":"8y83" + "partner":"8y7r" }, { "sim":136.0, @@ -834174,15 +837329,15 @@ }, { "sim":134.0, - "partner":"2dte" + "partner":"2dtx" }, { "sim":134.0, - "partner":"2dtx" + "partner":"2dtd" }, { "sim":134.0, - "partner":"2dtd" + "partner":"2dte" }, { "sim":134.0, @@ -834216,17 +837371,13 @@ "sim":131.0, "partner":"7p7y" }, - { - "sim":131.0, - "partner":"6xew" - }, { "sim":131.0, "partner":"6vsp" }, { "sim":131.0, - "partner":"7b81" + "partner":"6xew" }, { "sim":131.0, @@ -834240,6 +837391,10 @@ "sim":131.0, "partner":"7do7" }, + { + "sim":131.0, + "partner":"7b81" + }, { "sim":131.0, "partner":"4dml" @@ -834258,11 +837413,11 @@ }, { "sim":130.0, - "partner":"4i5g" + "partner":"6y1c" }, { "sim":130.0, - "partner":"6y1c" + "partner":"4i5g" }, { "sim":130.0, @@ -834326,11 +837481,11 @@ }, { "sim":124.0, - "partner":"8w0n" + "partner":"1rwb" }, { "sim":124.0, - "partner":"1rwb" + "partner":"8w0n" }, { "sim":123.0, @@ -834342,7 +837497,7 @@ }, { "sim":123.0, - "partner":"8y46" + "partner":"8y4b" }, { "sim":123.0, @@ -834350,7 +837505,7 @@ }, { "sim":123.0, - "partner":"8y4b" + "partner":"8y46" }, { "sim":123.0, @@ -834392,25 +837547,21 @@ "sim":122.0, "partner":"1yde" }, - { - "sim":122.0, - "partner":"6zde" - }, { "sim":122.0, "partner":"6gbt" }, { "sim":122.0, - "partner":"5en4" + "partner":"6zr6" }, { "sim":122.0, - "partner":"6zr6" + "partner":"6zt2" }, { "sim":122.0, - "partner":"6zt2" + "partner":"5en4" }, { "sim":122.0, @@ -834426,15 +837577,7 @@ }, { "sim":122.0, - "partner":"5o6o" - }, - { - "sim":122.0, - "partner":"5o6x" - }, - { - "sim":122.0, - "partner":"6qck" + "partner":"6zde" }, { "sim":122.0, @@ -834462,11 +837605,11 @@ }, { "sim":122.0, - "partner":"5o7c" + "partner":"6hno" }, { "sim":122.0, - "partner":"6hno" + "partner":"5o7c" }, { "sim":122.0, @@ -834482,11 +837625,11 @@ }, { "sim":122.0, - "partner":"5ics" + "partner":"6ffb" }, { "sim":122.0, - "partner":"6ffb" + "partner":"5ics" }, { "sim":122.0, @@ -834500,13 +837643,25 @@ "sim":122.0, "partner":"5l7y" }, + { + "sim":122.0, + "partner":"6gtu" + }, { "sim":122.0, "partner":"5jsf" }, { "sim":122.0, - "partner":"6gtu" + "partner":"6qck" + }, + { + "sim":122.0, + "partner":"5o6o" + }, + { + "sim":122.0, + "partner":"5o6x" }, { "sim":121.0, @@ -834534,15 +837689,15 @@ }, { "sim":121.0, - "partner":"7ejh" + "partner":"7eji" }, { "sim":121.0, - "partner":"7eji" + "partner":"7ve7" }, { "sim":121.0, - "partner":"7ve7" + "partner":"7ejh" }, { "sim":121.0, @@ -834614,27 +837769,15 @@ }, { "sim":120.0, - "partner":"3jq9" - }, - { - "sim":120.0, - "partner":"4cm3" - }, - { - "sim":120.0, - "partner":"4cmb" - }, - { - "sim":120.0, - "partner":"5jcj" + "partner":"2yhi" }, { "sim":120.0, - "partner":"6gdp" + "partner":"3bmc" }, { "sim":120.0, - "partner":"6rx0" + "partner":"3jqa" }, { "sim":120.0, @@ -834646,35 +837789,35 @@ }, { "sim":120.0, - "partner":"6gcl" + "partner":"4cm4" }, { "sim":120.0, - "partner":"2yhi" + "partner":"4cmc" }, { "sim":120.0, - "partner":"3bmc" + "partner":"5jcj" }, { "sim":120.0, - "partner":"4cm4" + "partner":"5k6a" }, { "sim":120.0, - "partner":"4cmc" + "partner":"6gcp" }, { "sim":120.0, - "partner":"5k6a" + "partner":"8of2" }, { "sim":120.0, - "partner":"3jqa" + "partner":"6gcq" }, { "sim":120.0, - "partner":"6gcp" + "partner":"6gd0" }, { "sim":120.0, @@ -834694,31 +837837,31 @@ }, { "sim":120.0, - "partner":"6gcq" + "partner":"4clr" }, { "sim":120.0, - "partner":"6gd0" + "partner":"4cme" }, { "sim":120.0, - "partner":"4clr" + "partner":"3bmo" }, { "sim":120.0, - "partner":"4cme" + "partner":"4cm6" }, { "sim":120.0, - "partner":"3bmo" + "partner":"3jqc" }, { "sim":120.0, - "partner":"4cm6" + "partner":"6gex" }, { "sim":120.0, - "partner":"3jqc" + "partner":"6tbx" }, { "sim":120.0, @@ -834742,11 +837885,7 @@ }, { "sim":120.0, - "partner":"6gex" - }, - { - "sim":120.0, - "partner":"6tbx" + "partner":"6rx6" }, { "sim":120.0, @@ -834762,35 +837901,35 @@ }, { "sim":120.0, - "partner":"6rx6" + "partner":"6gey" }, { "sim":120.0, - "partner":"5jdi" + "partner":"6hnc" }, { "sim":120.0, - "partner":"3gn2" + "partner":"5jdi" }, { "sim":120.0, - "partner":"4cle" + "partner":"3gn2" }, { "sim":120.0, - "partner":"6gey" + "partner":"4cle" }, { "sim":120.0, - "partner":"6hnc" + "partner":"4clx" }, { "sim":120.0, - "partner":"4clx" + "partner":"4cm8" }, { "sim":120.0, - "partner":"4cm8" + "partner":"7opj" }, { "sim":120.0, @@ -834802,7 +837941,7 @@ }, { "sim":120.0, - "partner":"7opj" + "partner":"6gd4" }, { "sim":120.0, @@ -834816,10 +837955,6 @@ "sim":120.0, "partner":"5jcx" }, - { - "sim":120.0, - "partner":"6gd4" - }, { "sim":120.0, "partner":"4clh" @@ -834838,11 +837973,11 @@ }, { "sim":120.0, - "partner":"4cmj" + "partner":"6hnr" }, { "sim":120.0, - "partner":"8of2" + "partner":"4cmj" }, { "sim":120.0, @@ -834850,12 +837985,16 @@ }, { "sim":120.0, - "partner":"6hnr" + "partner":"6how" }, { "sim":120.0, "partner":"4cma" }, + { + "sim":120.0, + "partner":"6gdo" + }, { "sim":120.0, "partner":"2x9g" @@ -834874,7 +838013,7 @@ }, { "sim":120.0, - "partner":"6how" + "partner":"6rx0" }, { "sim":120.0, @@ -834882,11 +838021,23 @@ }, { "sim":120.0, - "partner":"6gdo" + "partner":"4cm3" }, { - "sim":119.0, - "partner":"2uvd" + "sim":120.0, + "partner":"4cmb" + }, + { + "sim":120.0, + "partner":"6gdp" + }, + { + "sim":120.0, + "partner":"3jq9" + }, + { + "sim":120.0, + "partner":"6gcl" }, { "sim":119.0, @@ -834896,6 +838047,10 @@ "sim":119.0, "partner":"4nbv" }, + { + "sim":119.0, + "partner":"2uvd" + }, { "sim":119.0, "partner":"7pcs" @@ -834946,7 +838101,7 @@ }, { "sim":118.0, - "partner":"7a2b" + "partner":"6h07" }, { "sim":118.0, @@ -834954,15 +838109,15 @@ }, { "sim":118.0, - "partner":"6h07" + "partner":"6h1m" }, { "sim":118.0, - "partner":"6h1m" + "partner":"1nxq" }, { "sim":118.0, - "partner":"1nxq" + "partner":"7a2b" }, { "sim":118.0, @@ -835082,11 +838237,11 @@ }, { "sim":114.0, - "partner":"5cdy" + "partner":"5cej" }, { "sim":114.0, - "partner":"5cej" + "partner":"5cdy" }, { "sim":114.0, @@ -835214,11 +838369,11 @@ }, { "sim":111.0, - "partner":"8dt1" + "partner":"4trr" }, { "sim":111.0, - "partner":"4trr" + "partner":"8dt1" }, { "sim":111.0, @@ -835234,11 +838389,11 @@ }, { "sim":110.0, - "partner":"6t6p" + "partner":"6t6n" }, { "sim":110.0, - "partner":"6t6n" + "partner":"6t6p" }, { "sim":110.0, @@ -835262,11 +838417,11 @@ }, { "sim":110.0, - "partner":"8pa1" + "partner":"8pa2" }, { "sim":110.0, - "partner":"8pa2" + "partner":"8pa1" }, { "sim":110.0, @@ -835286,19 +838441,19 @@ }, { "sim":109.0, - "partner":"4qec" + "partner":"4qed" }, { "sim":109.0, - "partner":"4qed" + "partner":"4qec" }, { "sim":109.0, - "partner":"6ihi" + "partner":"8y4j" }, { "sim":109.0, - "partner":"8y4j" + "partner":"6ihi" }, { "sim":109.0, @@ -835572,10 +838727,6 @@ "sim":100.0, "partner":"1bdb" }, - { - "sim":100.0, - "partner":"6k8s" - }, { "sim":100.0, "partner":"6k8t" @@ -835585,8 +838736,8 @@ "partner":"6k8u" }, { - "sim":99.0, - "partner":"6t60" + "sim":100.0, + "partner":"6k8s" }, { "sim":99.0, @@ -835598,11 +838749,11 @@ }, { "sim":99.0, - "partner":"8jfa" + "partner":"6t60" }, { "sim":99.0, - "partner":"8jfg" + "partner":"8jfa" }, { "sim":99.0, @@ -835616,6 +838767,10 @@ "sim":99.0, "partner":"8jf9" }, + { + "sim":99.0, + "partner":"8jfg" + }, { "sim":99.0, "partner":"3pk0" @@ -835670,11 +838825,11 @@ }, { "sim":98.0, - "partner":"8eh2" + "partner":"8gbb" }, { "sim":98.0, - "partner":"8gbb" + "partner":"8eh2" }, { "sim":98.0, @@ -835728,17 +838883,13 @@ "sim":98.0, "partner":"1xg5" }, - { - "sim":98.0, - "partner":"8hfj" - }, { "sim":98.0, "partner":"8hfk" }, { "sim":98.0, - "partner":"3zv4" + "partner":"8hfj" }, { "sim":98.0, @@ -835760,6 +838911,10 @@ "sim":98.0, "partner":"3zv3" }, + { + "sim":98.0, + "partner":"3zv4" + }, { "sim":98.0, "partner":"6m9u" @@ -835796,6 +838951,10 @@ "sim":97.0, "partner":"2pd6" }, + { + "sim":97.0, + "partner":"8xvn" + }, { "sim":97.0, "partner":"6ow4" @@ -835826,11 +838985,11 @@ }, { "sim":96.0, - "partner":"3gk3" + "partner":"5vt6" }, { "sim":96.0, - "partner":"5vt6" + "partner":"3gk3" }, { "sim":96.0, @@ -835854,11 +839013,11 @@ }, { "sim":96.0, - "partner":"4jqc" + "partner":"4jx8" }, { "sim":96.0, - "partner":"4jx8" + "partner":"4jqc" }, { "sim":96.0, @@ -835884,17 +839043,13 @@ "sim":95.0, "partner":"3rwb" }, - { - "sim":95.0, - "partner":"8hde" - }, { "sim":95.0, "partner":"8hs9" }, { "sim":95.0, - "partner":"8hs5" + "partner":"8hde" }, { "sim":95.0, @@ -835904,6 +839059,10 @@ "sim":95.0, "partner":"8hdn" }, + { + "sim":95.0, + "partner":"8hs5" + }, { "sim":95.0, "partner":"8cbo" @@ -835938,11 +839097,11 @@ }, { "sim":95.0, - "partner":"8cbk" + "partner":"8cbl" }, { "sim":95.0, - "partner":"8cbl" + "partner":"8rr3" }, { "sim":95.0, @@ -835956,10 +839115,22 @@ "sim":95.0, "partner":"8cbm" }, + { + "sim":95.0, + "partner":"8rr4" + }, { "sim":95.0, "partner":"1so8" }, + { + "sim":95.0, + "partner":"8cbk" + }, + { + "sim":95.0, + "partner":"8rr1" + }, { "sim":95.0, "partner":"2o23" @@ -835990,11 +839161,11 @@ }, { "sim":94.0, - "partner":"8hs4" + "partner":"8hs6" }, { "sim":94.0, - "partner":"8hs6" + "partner":"8hs4" }, { "sim":94.0, @@ -836070,11 +839241,11 @@ }, { "sim":93.0, - "partner":"8sc0" + "partner":"8u9a" }, { "sim":93.0, - "partner":"8u9a" + "partner":"8sc0" }, { "sim":93.0, @@ -836166,11 +839337,11 @@ }, { "sim":91.0, - "partner":"1edo" + "partner":"2cdh" }, { "sim":91.0, - "partner":"2cdh" + "partner":"1edo" }, { "sim":91.0, @@ -836192,14 +839363,6 @@ "sim":91.0, "partner":"1e6w" }, - { - "sim":91.0, - "partner":"4bnv" - }, - { - "sim":91.0, - "partner":"4bo3" - }, { "sim":91.0, "partner":"4bnw" @@ -836268,6 +839431,14 @@ "sim":91.0, "partner":"4bo2" }, + { + "sim":91.0, + "partner":"4bnv" + }, + { + "sim":91.0, + "partner":"4bo3" + }, { "sim":90.0, "partner":"1e3s" @@ -836350,11 +839521,11 @@ }, { "sim":87.0, - "partner":"7dll" + "partner":"7dmg" }, { "sim":87.0, - "partner":"7dmg" + "partner":"7dll" }, { "sim":87.0, @@ -836416,10 +839587,6 @@ "sim":85.0, "partner":"3uic" }, - { - "sim":85.0, - "partner":"4j3f" - }, { "sim":85.0, "partner":"4j4t" @@ -836432,6 +839599,10 @@ "sim":85.0, "partner":"4j1n" }, + { + "sim":85.0, + "partner":"4j3f" + }, { "sim":85.0, "partner":"5g4k" @@ -836540,10 +839711,6 @@ "sim":82.0, "partner":"9jdt" }, - { - "sim":82.0, - "partner":"6gck" - }, { "sim":82.0, "partner":"4wcd" @@ -836572,6 +839739,10 @@ "sim":82.0, "partner":"2vz0" }, + { + "sim":82.0, + "partner":"6gck" + }, { "sim":82.0, "partner":"7qy3" @@ -836602,7 +839773,7 @@ }, { "sim":81.0, - "partner":"5mtr" + "partner":"4oxk" }, { "sim":81.0, @@ -836610,11 +839781,11 @@ }, { "sim":81.0, - "partner":"4oxk" + "partner":"5ugu" }, { "sim":81.0, - "partner":"5ugu" + "partner":"6yuu" }, { "sim":81.0, @@ -836624,10 +839795,6 @@ "sim":81.0, "partner":"4oyr" }, - { - "sim":81.0, - "partner":"6yuu" - }, { "sim":81.0, "partner":"5mtp" @@ -836648,6 +839815,10 @@ "sim":81.0, "partner":"4oim" }, + { + "sim":81.0, + "partner":"5mtr" + }, { "sim":81.0, "partner":"5ugs" @@ -836702,15 +839873,15 @@ }, { "sim":80.0, - "partner":"5cpb" + "partner":"5cpf" }, { "sim":80.0, - "partner":"5cpf" + "partner":"5cp8" }, { "sim":80.0, - "partner":"5cp8" + "partner":"5cpb" }, { "sim":79.0, @@ -836718,11 +839889,11 @@ }, { "sim":79.0, - "partner":"8cwl" + "partner":"3icc" }, { "sim":79.0, - "partner":"3icc" + "partner":"8cwl" }, { "sim":79.0, @@ -836774,15 +839945,15 @@ }, { "sim":78.0, - "partner":"1x7g" + "partner":"1x7h" }, { "sim":78.0, - "partner":"1x7h" + "partner":"1xr3" }, { "sim":78.0, - "partner":"1xr3" + "partner":"1x7g" }, { "sim":78.0, @@ -836926,15 +840097,15 @@ }, { "sim":74.0, - "partner":"3tpc" + "partner":"3tl3" }, { "sim":74.0, - "partner":"3vzq" + "partner":"3tpc" }, { "sim":74.0, - "partner":"3tl3" + "partner":"3vzq" }, { "sim":74.0, @@ -837042,11 +840213,11 @@ }, { "sim":71.0, - "partner":"3vzp" + "partner":"3vzs" }, { "sim":71.0, - "partner":"3vzs" + "partner":"3vzp" }, { "sim":71.0, @@ -837092,10 +840263,6 @@ "sim":70.0, "partner":"3ojf" }, - { - "sim":70.0, - "partner":"5ycs" - }, { "sim":70.0, "partner":"3afm" @@ -837112,6 +840279,10 @@ "sim":70.0, "partner":"5ycr" }, + { + "sim":70.0, + "partner":"5ycs" + }, { "sim":70.0, "partner":"6aa8" @@ -837174,15 +840345,15 @@ }, { "sim":68.0, - "partner":"8wov" + "partner":"8wop" }, { "sim":68.0, - "partner":"8wow" + "partner":"8wov" }, { "sim":68.0, - "partner":"8wop" + "partner":"8wow" }, { "sim":68.0, @@ -837230,39 +840401,39 @@ }, { "sim":67.0, - "partner":"8aeo" + "partner":"8aer" }, { "sim":67.0, - "partner":"8aer" + "partner":"8aet" }, { "sim":67.0, - "partner":"8aet" + "partner":"8aeo" }, { "sim":66.0, - "partner":"6yq0" + "partner":"6yq3" }, { "sim":66.0, - "partner":"3gy0" + "partner":"6yq6" }, { "sim":66.0, - "partner":"6yq3" + "partner":"3f5s" }, { "sim":66.0, - "partner":"6yq6" + "partner":"6ypz" }, { "sim":66.0, - "partner":"3f5s" + "partner":"6yq0" }, { "sim":66.0, - "partner":"6ypz" + "partner":"3gy0" }, { "sim":66.0, @@ -837270,11 +840441,11 @@ }, { "sim":66.0, - "partner":"5ilg" + "partner":"5ilo" }, { "sim":66.0, - "partner":"5ilo" + "partner":"5ilg" }, { "sim":66.0, @@ -837298,11 +840469,11 @@ }, { "sim":65.0, - "partner":"3f1k" + "partner":"3f1l" }, { "sim":65.0, - "partner":"3f1l" + "partner":"3f1k" }, { "sim":65.0, @@ -837382,11 +840553,11 @@ }, { "sim":64.0, - "partner":"7btm" + "partner":"7bsx" }, { "sim":64.0, - "partner":"7bsx" + "partner":"7btm" }, { "sim":64.0, @@ -837424,10 +840595,6 @@ "sim":63.0, "partner":"2q1w" }, - { - "sim":63.0, - "partner":"2y6r" - }, { "sim":63.0, "partner":"4a99" @@ -837449,12 +840616,12 @@ "partner":"2y6q" }, { - "sim":62.0, - "partner":"1qsg" + "sim":63.0, + "partner":"2y6r" }, { "sim":62.0, - "partner":"3dbp" + "partner":"1qsg" }, { "sim":62.0, @@ -837474,7 +840641,7 @@ }, { "sim":62.0, - "partner":"2pzm" + "partner":"3dbp" }, { "sim":62.0, @@ -837484,6 +840651,10 @@ "sim":62.0, "partner":"2pzl" }, + { + "sim":62.0, + "partner":"2pzm" + }, { "sim":62.0, "partner":"7us5" @@ -837586,11 +840757,11 @@ }, { "sim":60.0, - "partner":"6uuv" + "partner":"6uut" }, { "sim":60.0, - "partner":"6uut" + "partner":"6uuv" }, { "sim":59.0, @@ -837616,14 +840787,6 @@ "sim":59.0, "partner":"3lf2" }, - { - "sim":59.0, - "partner":"5ds3" - }, - { - "sim":59.0, - "partner":"6bhv" - }, { "sim":59.0, "partner":"6ntu" @@ -837638,11 +840801,11 @@ }, { "sim":59.0, - "partner":"6nrf" + "partner":"8fyz" }, { "sim":59.0, - "partner":"8fyz" + "partner":"6nrf" }, { "sim":59.0, @@ -837662,12 +840825,20 @@ }, { "sim":59.0, - "partner":"8jfn" + "partner":"6bhv" + }, + { + "sim":59.0, + "partner":"5ds3" }, { "sim":59.0, "partner":"8jfm" }, + { + "sim":59.0, + "partner":"8jfn" + }, { "sim":59.0, "partner":"8jfj" @@ -837746,23 +840917,23 @@ }, { "sim":58.0, - "partner":"6fm0" + "partner":"6fm3" }, { "sim":58.0, - "partner":"6rm2" + "partner":"6flf" }, { "sim":58.0, - "partner":"6fko" + "partner":"6fm0" }, { "sim":58.0, - "partner":"6fm3" + "partner":"6rm2" }, { "sim":58.0, - "partner":"6flf" + "partner":"6fko" }, { "sim":58.0, @@ -837806,23 +840977,23 @@ }, { "sim":58.0, - "partner":"7aqu" + "partner":"7cu0" }, { "sim":58.0, - "partner":"7aqv" + "partner":"7cu1" }, { "sim":58.0, - "partner":"7cu0" + "partner":"7cu2" }, { "sim":58.0, - "partner":"7cu1" + "partner":"7aqu" }, { "sim":58.0, - "partner":"7cu2" + "partner":"7aqv" }, { "sim":58.0, @@ -837870,11 +841041,11 @@ }, { "sim":57.0, - "partner":"6ze0" + "partner":"6zdz" }, { "sim":57.0, - "partner":"6zdz" + "partner":"6ze0" }, { "sim":57.0, @@ -837886,15 +841057,15 @@ }, { "sim":57.0, - "partner":"8zj0" + "partner":"8zi8" }, { "sim":57.0, - "partner":"8zhy" + "partner":"8zj0" }, { "sim":57.0, - "partner":"8zi8" + "partner":"8zhy" }, { "sim":57.0, @@ -837968,10 +841139,6 @@ "sim":56.0, "partner":"3nyw" }, - { - "sim":56.0, - "partner":"5qij" - }, { "sim":56.0, "partner":"5pgz" @@ -837990,7 +841157,7 @@ }, { "sim":56.0, - "partner":"7xif" + "partner":"5qij" }, { "sim":56.0, @@ -838004,6 +841171,10 @@ "sim":56.0, "partner":"7xii" }, + { + "sim":56.0, + "partner":"7xif" + }, { "sim":56.0, "partner":"4xbz" @@ -838150,11 +841321,11 @@ }, { "sim":55.0, - "partner":"7xrt" + "partner":"7xrv" }, { "sim":55.0, - "partner":"7xrv" + "partner":"7xrt" }, { "sim":55.0, @@ -838210,11 +841381,11 @@ }, { "sim":55.0, - "partner":"7epr" + "partner":"7eps" }, { "sim":55.0, - "partner":"7eps" + "partner":"7epr" }, { "sim":55.0, @@ -838300,10 +841471,6 @@ "sim":55.0, "partner":"6bia" }, - { - "sim":55.0, - "partner":"6bzn" - }, { "sim":55.0, "partner":"6bzz" @@ -838326,7 +841493,7 @@ }, { "sim":55.0, - "partner":"6p00" + "partner":"6bzn" }, { "sim":55.0, @@ -838342,11 +841509,11 @@ }, { "sim":55.0, - "partner":"4lu6" + "partner":"6p2v" }, { "sim":55.0, - "partner":"6p2v" + "partner":"4lu6" }, { "sim":55.0, @@ -838360,6 +841527,10 @@ "sim":55.0, "partner":"2e4g" }, + { + "sim":55.0, + "partner":"6p00" + }, { "sim":55.0, "partner":"2bf4" @@ -838406,11 +841577,11 @@ }, { "sim":54.0, - "partner":"7p4y" + "partner":"7p50" }, { "sim":54.0, - "partner":"7p50" + "partner":"7p4y" }, { "sim":54.0, @@ -838574,11 +841745,11 @@ }, { "sim":54.0, - "partner":"8tne" + "partner":"6ems" }, { "sim":54.0, - "partner":"6ems" + "partner":"8tne" }, { "sim":54.0, @@ -838614,15 +841785,15 @@ }, { "sim":54.0, - "partner":"5dvi" + "partner":"5dvj" }, { "sim":54.0, - "partner":"5dvj" + "partner":"5dvf" }, { "sim":54.0, - "partner":"5dvf" + "partner":"5dvi" }, { "sim":54.0, @@ -838686,11 +841857,11 @@ }, { "sim":53.0, - "partner":"5c7p" + "partner":"4kpc" }, { "sim":53.0, - "partner":"4kpc" + "partner":"5c7p" }, { "sim":53.0, @@ -838734,15 +841905,15 @@ }, { "sim":53.0, - "partner":"3th5" + "partner":"4gzl" }, { "sim":53.0, - "partner":"4gzl" + "partner":"4gzm" }, { "sim":53.0, - "partner":"4gzm" + "partner":"3th5" }, { "sim":53.0, @@ -838782,23 +841953,23 @@ }, { "sim":53.0, - "partner":"4njh" + "partner":"4njj" }, { "sim":53.0, - "partner":"4nji" + "partner":"4njk" }, { "sim":53.0, - "partner":"4njj" + "partner":"4njg" }, { "sim":53.0, - "partner":"4njk" + "partner":"4njh" }, { "sim":53.0, - "partner":"4njg" + "partner":"4nji" }, { "sim":53.0, @@ -838814,27 +841985,27 @@ }, { "sim":53.0, - "partner":"8wbk" + "partner":"8wbm" }, { "sim":53.0, - "partner":"8wbl" + "partner":"8wbn" }, { "sim":53.0, - "partner":"8wbm" + "partner":"8wbp" }, { "sim":53.0, - "partner":"8wbn" + "partner":"8wbq" }, { "sim":53.0, - "partner":"8wbp" + "partner":"8wbk" }, { "sim":53.0, - "partner":"8wbq" + "partner":"8wbl" }, { "sim":53.0, @@ -838890,15 +842061,15 @@ }, { "sim":53.0, - "partner":"5zm4" + "partner":"5zm2" }, { "sim":53.0, - "partner":"5zm2" + "partner":"5zm3" }, { "sim":53.0, - "partner":"5zm3" + "partner":"5zm4" }, { "sim":53.0, @@ -838922,15 +842093,15 @@ }, { "sim":53.0, - "partner":"3ggo" + "partner":"3ggp" }, { "sim":53.0, - "partner":"3ggp" + "partner":"3ggg" }, { "sim":53.0, - "partner":"3ggg" + "partner":"3ggo" }, { "sim":53.0, @@ -838944,14 +842115,6 @@ "sim":53.0, "partner":"5wri" }, - { - "sim":53.0, - "partner":"5mit" - }, - { - "sim":53.0, - "partner":"5z75" - }, { "sim":53.0, "partner":"5mjk" @@ -838968,6 +842131,10 @@ "sim":53.0, "partner":"5miq" }, + { + "sim":53.0, + "partner":"5z75" + }, { "sim":53.0, "partner":"5mir" @@ -838978,7 +842145,7 @@ }, { "sim":53.0, - "partner":"7drp" + "partner":"5mit" }, { "sim":53.0, @@ -838992,6 +842159,10 @@ "sim":53.0, "partner":"7dro" }, + { + "sim":53.0, + "partner":"7drp" + }, { "sim":53.0, "partner":"1tyy" @@ -839144,10 +842315,6 @@ "sim":53.0, "partner":"5o8e" }, - { - "sim":53.0, - "partner":"6rk2" - }, { "sim":53.0, "partner":"6rjo" @@ -839162,7 +842329,7 @@ }, { "sim":53.0, - "partner":"6x0h" + "partner":"6rk2" }, { "sim":53.0, @@ -839172,6 +842339,18 @@ "sim":53.0, "partner":"6x0k" }, + { + "sim":53.0, + "partner":"6x0h" + }, + { + "sim":53.0, + "partner":"8oy9" + }, + { + "sim":53.0, + "partner":"8oy4" + }, { "sim":53.0, "partner":"8oya" @@ -839208,14 +842387,6 @@ "sim":53.0, "partner":"8oy3" }, - { - "sim":53.0, - "partner":"8oy9" - }, - { - "sim":53.0, - "partner":"8oy4" - }, { "sim":53.0, "partner":"1tz7" @@ -839224,10 +842395,6 @@ "sim":53.0, "partner":"4pxg" }, - { - "sim":53.0, - "partner":"2cj9" - }, { "sim":53.0, "partner":"2cja" @@ -839242,7 +842409,7 @@ }, { "sim":53.0, - "partner":"2r0p" + "partner":"2cj9" }, { "sim":53.0, @@ -839264,6 +842431,10 @@ "sim":53.0, "partner":"3ept" }, + { + "sim":53.0, + "partner":"2r0p" + }, { "sim":53.0, "partner":"6a37" @@ -839302,11 +842473,11 @@ }, { "sim":53.0, - "partner":"2zxh" + "partner":"2zxi" }, { "sim":53.0, - "partner":"2zxi" + "partner":"2zxh" }, { "sim":53.0, @@ -839358,27 +842529,27 @@ }, { "sim":52.0, - "partner":"4evc" + "partner":"3ta8" }, { "sim":52.0, - "partner":"4evd" + "partner":"3t9j" }, { "sim":52.0, - "partner":"4eve" + "partner":"4evb" }, { "sim":52.0, - "partner":"3ta8" + "partner":"4evc" }, { "sim":52.0, - "partner":"3t9j" + "partner":"4evd" }, { "sim":52.0, - "partner":"4evb" + "partner":"4eve" }, { "sim":52.0, @@ -839418,11 +842589,11 @@ }, { "sim":52.0, - "partner":"8jnr" + "partner":"2iuw" }, { "sim":52.0, - "partner":"2iuw" + "partner":"8jnr" }, { "sim":52.0, @@ -839448,10 +842619,6 @@ "sim":52.0, "partner":"2qw4" }, - { - "sim":52.0, - "partner":"2rbe" - }, { "sim":52.0, "partner":"3nd1" @@ -839464,6 +842631,10 @@ "sim":52.0, "partner":"3ey4" }, + { + "sim":52.0, + "partner":"2rbe" + }, { "sim":52.0, "partner":"6noo" @@ -839522,23 +842693,19 @@ }, { "sim":52.0, - "partner":"6mql" - }, - { - "sim":52.0, - "partner":"6mq9" + "partner":"6mqb" }, { "sim":52.0, - "partner":"6mqb" + "partner":"6mqk" }, { "sim":52.0, - "partner":"6mqk" + "partner":"6mql" }, { "sim":52.0, - "partner":"4rtl" + "partner":"6mq9" }, { "sim":52.0, @@ -839580,6 +842747,10 @@ "sim":52.0, "partner":"4rtk" }, + { + "sim":52.0, + "partner":"4rtl" + }, { "sim":52.0, "partner":"7c5e" @@ -839596,10 +842767,6 @@ "sim":52.0, "partner":"4otk" }, - { - "sim":52.0, - "partner":"3aio" - }, { "sim":52.0, "partner":"3aik" @@ -839618,19 +842785,23 @@ }, { "sim":52.0, - "partner":"3tmc" + "partner":"3aio" }, { "sim":52.0, - "partner":"3tmd" + "partner":"3tm8" }, { "sim":52.0, - "partner":"3tm8" + "partner":"3tmb" }, { "sim":52.0, - "partner":"3tmb" + "partner":"3tmc" + }, + { + "sim":52.0, + "partner":"3tmd" }, { "sim":52.0, @@ -839648,10 +842819,6 @@ "sim":52.0, "partner":"2fg7" }, - { - "sim":52.0, - "partner":"4wlo" - }, { "sim":52.0, "partner":"4wle" @@ -839674,12 +842841,16 @@ }, { "sim":52.0, - "partner":"7djq" + "partner":"4wlo" }, { "sim":52.0, "partner":"7ewo" }, + { + "sim":52.0, + "partner":"7djq" + }, { "sim":52.0, "partner":"3obw" @@ -839710,11 +842881,11 @@ }, { "sim":52.0, - "partner":"6wa9" + "partner":"6wa6" }, { "sim":52.0, - "partner":"6wa6" + "partner":"6wa9" }, { "sim":52.0, @@ -839726,11 +842897,11 @@ }, { "sim":52.0, - "partner":"3wkr" + "partner":"3wks" }, { "sim":52.0, - "partner":"3wks" + "partner":"3wkr" }, { "sim":52.0, @@ -839856,17 +843027,13 @@ "sim":51.0, "partner":"3va1" }, - { - "sim":51.0, - "partner":"3va4" - }, { "sim":51.0, "partner":"6t3o" }, { "sim":51.0, - "partner":"3imo" + "partner":"3va4" }, { "sim":51.0, @@ -839876,6 +843043,10 @@ "sim":51.0, "partner":"3fwt" }, + { + "sim":51.0, + "partner":"3imo" + }, { "sim":51.0, "partner":"7zyb" @@ -839924,10 +843095,6 @@ "sim":51.0, "partner":"4luq" }, - { - "sim":51.0, - "partner":"5zrk" - }, { "sim":51.0, "partner":"5zrl" @@ -839964,6 +843131,10 @@ "sim":51.0, "partner":"5zri" }, + { + "sim":51.0, + "partner":"5zrk" + }, { "sim":51.0, "partner":"1jjr" @@ -839988,17 +843159,13 @@ "sim":51.0, "partner":"8fxd" }, - { - "sim":51.0, - "partner":"3ph3" - }, { "sim":51.0, "partner":"8fvv" }, { "sim":51.0, - "partner":"3ph4" + "partner":"3ph3" }, { "sim":51.0, @@ -840006,15 +843173,15 @@ }, { "sim":51.0, - "partner":"8yeq" + "partner":"3ph4" }, { "sim":51.0, - "partner":"4n82" + "partner":"8yeq" }, { "sim":51.0, - "partner":"1x24" + "partner":"4n82" }, { "sim":51.0, @@ -840026,11 +843193,11 @@ }, { "sim":51.0, - "partner":"5e3b" + "partner":"1x24" }, { "sim":51.0, - "partner":"2h16" + "partner":"5e3b" }, { "sim":51.0, @@ -840040,6 +843207,10 @@ "sim":51.0, "partner":"8ar9" }, + { + "sim":51.0, + "partner":"2h16" + }, { "sim":51.0, "partner":"2hvv" @@ -840050,11 +843221,11 @@ }, { "sim":51.0, - "partner":"8p50" + "partner":"5c2o" }, { "sim":51.0, - "partner":"5c2o" + "partner":"8p50" }, { "sim":51.0, @@ -840142,15 +843313,11 @@ }, { "sim":51.0, - "partner":"6pj9" - }, - { - "sim":51.0, - "partner":"6pja" + "partner":"6pjp" }, { "sim":51.0, - "partner":"6pjp" + "partner":"6pjq" }, { "sim":51.0, @@ -840158,11 +843325,11 @@ }, { "sim":51.0, - "partner":"6pjq" + "partner":"6pjr" }, { "sim":51.0, - "partner":"6pjr" + "partner":"6pju" }, { "sim":51.0, @@ -840172,10 +843339,6 @@ "sim":51.0, "partner":"5f5d" }, - { - "sim":51.0, - "partner":"6pju" - }, { "sim":51.0, "partner":"4njp" @@ -840198,15 +843361,19 @@ }, { "sim":51.0, - "partner":"5f5j" + "partner":"6pj5" }, { "sim":51.0, - "partner":"6pj5" + "partner":"6pj7" }, { "sim":51.0, - "partner":"6pj7" + "partner":"5f5j" + }, + { + "sim":51.0, + "partner":"6pj8" }, { "sim":51.0, @@ -840214,11 +843381,11 @@ }, { "sim":51.0, - "partner":"6pj8" + "partner":"6pj9" }, { "sim":51.0, - "partner":"6mwy" + "partner":"6pja" }, { "sim":51.0, @@ -840244,6 +843411,10 @@ "sim":51.0, "partner":"4h3h" }, + { + "sim":51.0, + "partner":"6mwy" + }, { "sim":51.0, "partner":"2dch" @@ -840294,27 +843465,27 @@ }, { "sim":51.0, - "partner":"7mnq" + "partner":"7mns" }, { "sim":51.0, - "partner":"7mnr" + "partner":"7mnt" }, { "sim":51.0, - "partner":"7mns" + "partner":"7mnu" }, { "sim":51.0, - "partner":"7mnt" + "partner":"7mnv" }, { "sim":51.0, - "partner":"7mnu" + "partner":"7mnq" }, { "sim":51.0, - "partner":"7mnv" + "partner":"7mnr" }, { "sim":51.0, @@ -840332,25 +843503,21 @@ "sim":51.0, "partner":"2dpt" }, - { - "sim":51.0, - "partner":"6ey1" - }, { "sim":51.0, "partner":"6f0w" }, { "sim":51.0, - "partner":"2wyv" + "partner":"6ey1" }, { "sim":51.0, - "partner":"2yw9" + "partner":"2wyw" }, { "sim":51.0, - "partner":"2wyw" + "partner":"2yw9" }, { "sim":51.0, @@ -840368,6 +843535,10 @@ "sim":51.0, "partner":"2wyu" }, + { + "sim":51.0, + "partner":"2wyv" + }, { "sim":51.0, "partner":"6azq" @@ -840470,11 +843641,11 @@ }, { "sim":51.0, - "partner":"4q2g" + "partner":"4q2e" }, { "sim":51.0, - "partner":"4q2e" + "partner":"4q2g" }, { "sim":51.0, @@ -840494,11 +843665,11 @@ }, { "sim":51.0, - "partner":"4oj8" + "partner":"6y63" }, { "sim":51.0, - "partner":"6y63" + "partner":"4oj8" }, { "sim":51.0, @@ -840518,11 +843689,7 @@ }, { "sim":51.0, - "partner":"3h26" - }, - { - "sim":51.0, - "partner":"1twz" + "partner":"1tx0" }, { "sim":51.0, @@ -840532,10 +843699,6 @@ "sim":51.0, "partner":"4d8a" }, - { - "sim":51.0, - "partner":"1tx0" - }, { "sim":51.0, "partner":"1tx2" @@ -840648,6 +843811,14 @@ "sim":51.0, "partner":"3h24" }, + { + "sim":51.0, + "partner":"3h26" + }, + { + "sim":51.0, + "partner":"1twz" + }, { "sim":51.0, "partner":"4biu" @@ -840682,11 +843853,11 @@ }, { "sim":51.0, - "partner":"3ta4" + "partner":"3t9w" }, { "sim":51.0, - "partner":"3t9w" + "partner":"3ta4" }, { "sim":51.0, @@ -840706,11 +843877,11 @@ }, { "sim":51.0, - "partner":"5lsg" + "partner":"6t9c" }, { "sim":51.0, - "partner":"6t9c" + "partner":"5lsg" }, { "sim":51.0, @@ -840730,35 +843901,31 @@ }, { "sim":51.0, - "partner":"2oau" + "partner":"6uzh" }, { "sim":51.0, - "partner":"4hwa" + "partner":"2oau" }, { "sim":51.0, - "partner":"6uzh" + "partner":"4hwa" }, { "sim":51.0, "partner":"8tms" }, - { - "sim":51.0, - "partner":"5uto" - }, { "sim":51.0, "partner":"7scl" }, { "sim":51.0, - "partner":"4rnc" + "partner":"5uto" }, { "sim":51.0, - "partner":"6y5x" + "partner":"4rnc" }, { "sim":51.0, @@ -840766,11 +843933,7 @@ }, { "sim":51.0, - "partner":"3g3d" - }, - { - "sim":51.0, - "partner":"7ag7" + "partner":"6y5x" }, { "sim":51.0, @@ -840792,13 +843955,17 @@ "sim":51.0, "partner":"7ne2" }, + { + "sim":51.0, + "partner":"7ag7" + }, { "sim":51.0, "partner":"4hkp" }, { "sim":51.0, - "partner":"5ybr" + "partner":"3g3d" }, { "sim":51.0, @@ -840832,6 +843999,10 @@ "sim":51.0, "partner":"5ybq" }, + { + "sim":51.0, + "partner":"5ybr" + }, { "sim":51.0, "partner":"1ynp" @@ -840914,11 +844085,11 @@ }, { "sim":51.0, - "partner":"8zj5" + "partner":"8qfb" }, { "sim":51.0, - "partner":"8qfb" + "partner":"8zj5" }, { "sim":51.0, @@ -840934,39 +844105,39 @@ }, { "sim":51.0, - "partner":"6q4x" + "partner":"5u0n" }, { "sim":51.0, - "partner":"5tyq" + "partner":"6q4z" }, { "sim":51.0, - "partner":"5u19" + "partner":"5u1e" }, { "sim":51.0, - "partner":"6q4y" + "partner":"5u0t" }, { "sim":51.0, - "partner":"5u0n" + "partner":"5u1i" }, { "sim":51.0, - "partner":"5u1e" + "partner":"6q4x" }, { "sim":51.0, - "partner":"6q4z" + "partner":"6q4y" }, { "sim":51.0, - "partner":"5u0t" + "partner":"5tyq" }, { "sim":51.0, - "partner":"5u1i" + "partner":"5u19" }, { "sim":51.0, @@ -840990,11 +844161,11 @@ }, { "sim":51.0, - "partner":"5zkj" + "partner":"6iid" }, { "sim":51.0, - "partner":"6iid" + "partner":"8g5w" }, { "sim":51.0, @@ -841002,15 +844173,15 @@ }, { "sim":51.0, - "partner":"8g5w" + "partner":"8g5x" }, { "sim":51.0, - "partner":"8g5x" + "partner":"7txa" }, { "sim":51.0, - "partner":"7txa" + "partner":"7txg" }, { "sim":51.0, @@ -841018,7 +844189,7 @@ }, { "sim":51.0, - "partner":"7txg" + "partner":"5zkj" }, { "sim":51.0, @@ -841034,7 +844205,7 @@ }, { "sim":51.0, - "partner":"6pi5" + "partner":"6pi6" }, { "sim":51.0, @@ -841042,27 +844213,27 @@ }, { "sim":51.0, - "partner":"6pi6" + "partner":"1m1m" }, { "sim":51.0, - "partner":"1m1m" + "partner":"8afu" }, { "sim":51.0, - "partner":"8afu" + "partner":"6pi5" }, { "sim":51.0, - "partner":"4d2w" + "partner":"4d2p" }, { "sim":51.0, - "partner":"8phd" + "partner":"8phv" }, { "sim":51.0, - "partner":"4d2p" + "partner":"8phd" }, { "sim":51.0, @@ -841094,19 +844265,19 @@ }, { "sim":51.0, - "partner":"8phv" + "partner":"4d2w" }, { "sim":51.0, - "partner":"2x6t" + "partner":"2x86" }, { "sim":51.0, - "partner":"2x86" + "partner":"5y3x" }, { "sim":51.0, - "partner":"5y3x" + "partner":"2x6t" }, { "sim":51.0, @@ -841136,21 +844307,17 @@ "sim":51.0, "partner":"4g5h" }, - { - "sim":51.0, - "partner":"8uas" - }, { "sim":51.0, "partner":"8uar" }, { "sim":51.0, - "partner":"5gov" + "partner":"8uas" }, { "sim":51.0, - "partner":"4m1i" + "partner":"5gov" }, { "sim":51.0, @@ -841164,6 +844331,10 @@ "sim":51.0, "partner":"4m1h" }, + { + "sim":51.0, + "partner":"4m1i" + }, { "sim":51.0, "partner":"2pvp" @@ -841220,22 +844391,6 @@ "sim":51.0, "partner":"6nej" }, - { - "sim":51.0, - "partner":"5zzx" - }, - { - "sim":51.0, - "partner":"6a0d" - }, - { - "sim":51.0, - "partner":"5zzy" - }, - { - "sim":51.0, - "partner":"6a0v" - }, { "sim":51.0, "partner":"5zzz" @@ -841390,12 +844545,28 @@ }, { "sim":51.0, - "partner":"4zhs" + "partner":"5zzx" + }, + { + "sim":51.0, + "partner":"6a0d" + }, + { + "sim":51.0, + "partner":"5zzy" + }, + { + "sim":51.0, + "partner":"6a0v" }, { "sim":51.0, "partner":"4zic" }, + { + "sim":51.0, + "partner":"4zhs" + }, { "sim":51.0, "partner":"8skn" @@ -841412,10 +844583,6 @@ "sim":51.0, "partner":"5kvs" }, - { - "sim":51.0, - "partner":"7azd" - }, { "sim":51.0, "partner":"7az5" @@ -841448,13 +844615,17 @@ "sim":51.0, "partner":"7az8" }, + { + "sim":51.0, + "partner":"7azg" + }, { "sim":51.0, "partner":"5x06" }, { "sim":51.0, - "partner":"7azg" + "partner":"7azc" }, { "sim":51.0, @@ -841462,11 +844633,11 @@ }, { "sim":51.0, - "partner":"7azc" + "partner":"3ban" }, { "sim":51.0, - "partner":"3ban" + "partner":"7azd" }, { "sim":51.0, @@ -841490,7 +844661,7 @@ }, { "sim":51.0, - "partner":"6kjh" + "partner":"6y9d" }, { "sim":51.0, @@ -841498,43 +844669,39 @@ }, { "sim":51.0, - "partner":"6y8j" - }, - { - "sim":51.0, - "partner":"6y9c" + "partner":"6kjp" }, { "sim":51.0, - "partner":"6y9d" + "partner":"6kjq" }, { "sim":51.0, - "partner":"6kjj" + "partner":"6kjr" }, { "sim":51.0, - "partner":"6kjp" + "partner":"6kjt" }, { "sim":51.0, - "partner":"6kjq" + "partner":"6y8s" }, { "sim":51.0, - "partner":"6kjr" + "partner":"6kjh" }, { "sim":51.0, - "partner":"6kjt" + "partner":"6y8j" }, { "sim":51.0, - "partner":"6y8s" + "partner":"6y9c" }, { "sim":51.0, - "partner":"4wwv" + "partner":"6kjj" }, { "sim":51.0, @@ -841548,6 +844715,10 @@ "sim":51.0, "partner":"5zzu" }, + { + "sim":51.0, + "partner":"4wwv" + }, { "sim":51.0, "partner":"5ahl" @@ -841566,11 +844737,11 @@ }, { "sim":51.0, - "partner":"8gqm" + "partner":"8gqf" }, { "sim":51.0, - "partner":"8gqf" + "partner":"8gqm" }, { "sim":51.0, @@ -841590,11 +844761,11 @@ }, { "sim":51.0, - "partner":"8wch" + "partner":"5x6b" }, { "sim":51.0, - "partner":"5x6b" + "partner":"8wch" }, { "sim":51.0, @@ -841602,15 +844773,15 @@ }, { "sim":51.0, - "partner":"6j83" + "partner":"8jrl" }, { "sim":51.0, - "partner":"6j84" + "partner":"6j83" }, { "sim":51.0, - "partner":"8jrl" + "partner":"6j84" }, { "sim":51.0, @@ -841624,14 +844795,6 @@ "sim":51.0, "partner":"7ag4" }, - { - "sim":51.0, - "partner":"2ca0" - }, - { - "sim":51.0, - "partner":"4b7s" - }, { "sim":51.0, "partner":"2vz7" @@ -841680,6 +844843,14 @@ "sim":51.0, "partner":"4umz" }, + { + "sim":51.0, + "partner":"2ca0" + }, + { + "sim":51.0, + "partner":"4b7s" + }, { "sim":51.0, "partner":"7yp3" @@ -841706,15 +844877,15 @@ }, { "sim":51.0, - "partner":"7xbn" + "partner":"7xbm" }, { "sim":51.0, - "partner":"7xbo" + "partner":"7xbn" }, { "sim":51.0, - "partner":"7xbm" + "partner":"7xbo" }, { "sim":51.0, @@ -841742,11 +844913,11 @@ }, { "sim":51.0, - "partner":"6f47" + "partner":"6f4e" }, { "sim":51.0, - "partner":"6f4e" + "partner":"6f47" }, { "sim":51.0, @@ -841756,10 +844927,6 @@ "sim":51.0, "partner":"6qps" }, - { - "sim":51.0, - "partner":"6oi8" - }, { "sim":51.0, "partner":"4mv1" @@ -841796,6 +844963,10 @@ "sim":51.0, "partner":"6ojh" }, + { + "sim":51.0, + "partner":"6oi8" + }, { "sim":51.0, "partner":"6psm" @@ -841814,15 +844985,15 @@ }, { "sim":51.0, - "partner":"6gcn" + "partner":"5kr3" }, { "sim":51.0, - "partner":"6gco" + "partner":"6gcn" }, { "sim":51.0, - "partner":"5kr3" + "partner":"6gco" }, { "sim":51.0, @@ -841868,10 +845039,6 @@ "sim":51.0, "partner":"7qdx" }, - { - "sim":51.0, - "partner":"4dqw" - }, { "sim":51.0, "partner":"6gjv" @@ -841882,7 +845049,7 @@ }, { "sim":51.0, - "partner":"5klk" + "partner":"4dqw" }, { "sim":51.0, @@ -841906,47 +845073,51 @@ }, { "sim":51.0, - "partner":"8iat" + "partner":"5klk" }, { "sim":51.0, - "partner":"8zly" + "partner":"8iau" }, { "sim":51.0, - "partner":"8iau" + "partner":"8iav" }, { "sim":51.0, - "partner":"8xw6" + "partner":"8zly" }, { "sim":51.0, - "partner":"8iav" + "partner":"8iaw" }, { "sim":51.0, - "partner":"8xw7" + "partner":"8iax" }, { "sim":51.0, - "partner":"8xw8" + "partner":"8xw6" }, { "sim":51.0, - "partner":"8iaw" + "partner":"8xw7" }, { "sim":51.0, - "partner":"8iax" + "partner":"8ias" }, { "sim":51.0, - "partner":"8xw9" + "partner":"8xw8" }, { "sim":51.0, - "partner":"8ias" + "partner":"8iat" + }, + { + "sim":51.0, + "partner":"8xw9" }, { "sim":51.0, @@ -842020,10 +845191,6 @@ "sim":51.0, "partner":"4lh3" }, - { - "sim":51.0, - "partner":"2q5l" - }, { "sim":51.0, "partner":"2q5o" @@ -842040,6 +845207,10 @@ "sim":51.0, "partner":"2q5j" }, + { + "sim":51.0, + "partner":"2q5l" + }, { "sim":51.0, "partner":"7jvh" @@ -842082,15 +845253,15 @@ }, { "sim":51.0, - "partner":"5lj7" + "partner":"5lil" }, { "sim":51.0, - "partner":"5lil" + "partner":"5lj6" }, { "sim":51.0, - "partner":"5lj6" + "partner":"5lj7" }, { "sim":51.0, @@ -842142,15 +845313,15 @@ }, { "sim":51.0, - "partner":"6tsh" + "partner":"6tsk" }, { "sim":51.0, - "partner":"6tte" + "partner":"6tsh" }, { "sim":51.0, - "partner":"6tsk" + "partner":"6tte" }, { "sim":51.0, @@ -842162,11 +845333,11 @@ }, { "sim":50.0, - "partner":"2ktm" + "partner":"5yrz" }, { "sim":50.0, - "partner":"5yrz" + "partner":"2ktm" }, { "sim":50.0, @@ -842182,11 +845353,11 @@ }, { "sim":50.0, - "partner":"5cvo" + "partner":"6nyo" }, { "sim":50.0, - "partner":"6nyo" + "partner":"5cvo" }, { "sim":50.0, @@ -842308,10 +845479,6 @@ "sim":50.0, "partner":"4yxl" }, - { - "sim":50.0, - "partner":"1vb6" - }, { "sim":50.0, "partner":"4kiw" @@ -842324,6 +845491,10 @@ "sim":50.0, "partner":"1v9z" }, + { + "sim":50.0, + "partner":"1vb6" + }, { "sim":50.0, "partner":"2znz" @@ -842410,11 +845581,11 @@ }, { "sim":50.0, - "partner":"5k24" + "partner":"5k22" }, { "sim":50.0, - "partner":"5k22" + "partner":"5k24" }, { "sim":50.0, @@ -842482,11 +845653,11 @@ }, { "sim":50.0, - "partner":"4kce" + "partner":"8yjm" }, { "sim":50.0, - "partner":"8yjm" + "partner":"4kce" }, { "sim":50.0, @@ -842502,7 +845673,7 @@ }, { "sim":50.0, - "partner":"8xop" + "partner":"3l4c" }, { "sim":50.0, @@ -842510,19 +845681,19 @@ }, { "sim":50.0, - "partner":"3l4c" + "partner":"8xop" }, { "sim":50.0, - "partner":"6j0l" + "partner":"6j0g" }, { "sim":50.0, - "partner":"6j0g" + "partner":"6j0k" }, { "sim":50.0, - "partner":"6j0k" + "partner":"6j0l" }, { "sim":50.0, @@ -842566,19 +845737,19 @@ }, { "sim":50.0, - "partner":"8vip" + "partner":"8vit" }, { "sim":50.0, - "partner":"8viq" + "partner":"8vip" }, { "sim":50.0, - "partner":"8vir" + "partner":"8viq" }, { "sim":50.0, - "partner":"8vit" + "partner":"8vir" }, { "sim":50.0, @@ -842622,19 +845793,19 @@ }, { "sim":50.0, - "partner":"7qej" + "partner":"9ftb" }, { "sim":50.0, - "partner":"9ftb" + "partner":"9ftc" }, { "sim":50.0, - "partner":"7qek" + "partner":"7qej" }, { "sim":50.0, - "partner":"9ftc" + "partner":"7qek" }, { "sim":50.0, @@ -842758,11 +845929,11 @@ }, { "sim":50.0, - "partner":"6ub7" + "partner":"3jz0" }, { "sim":50.0, - "partner":"3jz0" + "partner":"6ub7" }, { "sim":50.0, @@ -842770,47 +845941,47 @@ }, { "sim":50.0, - "partner":"3h4v" + "partner":"4rdi" }, { "sim":50.0, - "partner":"4rdh" + "partner":"5l42" }, { "sim":50.0, - "partner":"7pxx" + "partner":"2bf7" }, { "sim":50.0, - "partner":"4rdi" + "partner":"2bfm" }, { "sim":50.0, - "partner":"5l42" + "partner":"2bfa" }, { "sim":50.0, - "partner":"2bf7" + "partner":"2bfo" }, { "sim":50.0, - "partner":"2bfm" + "partner":"2bfp" }, { "sim":50.0, - "partner":"2bfa" + "partner":"3h4v" }, { "sim":50.0, - "partner":"2bfo" + "partner":"5l4n" }, { "sim":50.0, - "partner":"2bfp" + "partner":"4rdh" }, { "sim":50.0, - "partner":"5l4n" + "partner":"7pxx" }, { "sim":50.0, @@ -842850,11 +846021,11 @@ }, { "sim":50.0, - "partner":"6rxc" + "partner":"1e7w" }, { "sim":50.0, - "partner":"1e7w" + "partner":"6rxc" }, { "sim":50.0, @@ -842914,23 +846085,23 @@ }, { "sim":50.0, - "partner":"1l9x" + "partner":"3u3k" }, { "sim":50.0, - "partner":"3u3r" + "partner":"1l9x" }, { "sim":50.0, - "partner":"3u3k" + "partner":"3u3m" }, { "sim":50.0, - "partner":"3u3m" + "partner":"3u3o" }, { "sim":50.0, - "partner":"3u3o" + "partner":"3u3r" }, { "sim":50.0, @@ -843026,39 +846197,39 @@ }, { "sim":50.0, - "partner":"7v52" + "partner":"7v56" }, { "sim":50.0, - "partner":"7v54" + "partner":"7v57" }, { "sim":50.0, - "partner":"7v56" + "partner":"7fh5" }, { "sim":50.0, - "partner":"7v57" + "partner":"7v7x" }, { "sim":50.0, - "partner":"7fh5" + "partner":"7v52" }, { "sim":50.0, - "partner":"7v7x" + "partner":"7v54" }, { "sim":50.0, - "partner":"4w7v" + "partner":"4w7u" }, { "sim":50.0, - "partner":"4w7w" + "partner":"4w7v" }, { "sim":50.0, - "partner":"4w7u" + "partner":"4w7w" }, { "sim":50.0, @@ -843130,39 +846301,39 @@ }, { "sim":50.0, - "partner":"5glm" + "partner":"5glo" }, { "sim":50.0, - "partner":"6cwo" + "partner":"5glp" }, { "sim":50.0, - "partner":"5gln" + "partner":"5glq" }, { "sim":50.0, - "partner":"5glo" + "partner":"5glr" }, { "sim":50.0, - "partner":"5glp" + "partner":"5glk" }, { "sim":50.0, - "partner":"5glq" + "partner":"5gll" }, { "sim":50.0, - "partner":"5glr" + "partner":"6cwo" }, { "sim":50.0, - "partner":"5glk" + "partner":"5glm" }, { "sim":50.0, - "partner":"5gll" + "partner":"5gln" }, { "sim":50.0, @@ -843192,10 +846363,6 @@ "sim":50.0, "partner":"4u6s" }, - { - "sim":50.0, - "partner":"6sf5" - }, { "sim":50.0, "partner":"8shh" @@ -843210,23 +846377,23 @@ }, { "sim":50.0, - "partner":"7kwm" + "partner":"6sf5" }, { "sim":50.0, - "partner":"8jwl" + "partner":"7kwm" }, { "sim":50.0, - "partner":"8jwo" + "partner":"6tg2" }, { "sim":50.0, - "partner":"5l9l" + "partner":"8jwl" }, { "sim":50.0, - "partner":"6tg2" + "partner":"8jwo" }, { "sim":50.0, @@ -843234,11 +846401,11 @@ }, { "sim":50.0, - "partner":"8jwm" + "partner":"6tg3" }, { "sim":50.0, - "partner":"6tg3" + "partner":"8jwm" }, { "sim":50.0, @@ -843258,7 +846425,7 @@ }, { "sim":50.0, - "partner":"5g6t" + "partner":"5l9l" }, { "sim":50.0, @@ -843286,7 +846453,7 @@ }, { "sim":50.0, - "partner":"1vsu" + "partner":"5g6t" }, { "sim":50.0, @@ -843302,15 +846469,15 @@ }, { "sim":50.0, - "partner":"7zgj" + "partner":"1vsu" }, { "sim":50.0, - "partner":"7zgk" + "partner":"7zgj" }, { "sim":50.0, - "partner":"7f6d" + "partner":"7zgk" }, { "sim":50.0, @@ -843320,6 +846487,10 @@ "sim":50.0, "partner":"6v8a" }, + { + "sim":50.0, + "partner":"7f6d" + }, { "sim":50.0, "partner":"3wnb" @@ -843404,10 +846575,6 @@ "sim":50.0, "partner":"8is0" }, - { - "sim":50.0, - "partner":"6c8v" - }, { "sim":50.0, "partner":"3vvl" @@ -843422,11 +846589,11 @@ }, { "sim":50.0, - "partner":"6s31" + "partner":"6c8v" }, { "sim":50.0, - "partner":"6s0g" + "partner":"6s31" }, { "sim":50.0, @@ -843438,16 +846605,20 @@ }, { "sim":50.0, - "partner":"7jyb" + "partner":"6s0g" }, { "sim":50.0, - "partner":"7k64" + "partner":"7jyb" }, { "sim":50.0, "partner":"6m7l" }, + { + "sim":50.0, + "partner":"7k64" + }, { "sim":50.0, "partner":"2o1b" @@ -843480,10 +846651,6 @@ "sim":50.0, "partner":"3k02" }, - { - "sim":50.0, - "partner":"2gqn" - }, { "sim":50.0, "partner":"3i65" @@ -843508,6 +846675,10 @@ "sim":50.0, "partner":"2fq6" }, + { + "sim":50.0, + "partner":"2gqn" + }, { "sim":50.0, "partner":"7bvt" @@ -843518,11 +846689,11 @@ }, { "sim":50.0, - "partner":"8u2m" + "partner":"8ukz" }, { "sim":50.0, - "partner":"8ukz" + "partner":"8u2m" }, { "sim":50.0, @@ -843586,24 +846757,20 @@ }, { "sim":50.0, - "partner":"6v99" + "partner":"6v96" }, { "sim":50.0, - "partner":"6v9a" + "partner":"6v99" }, { "sim":50.0, - "partner":"6v96" + "partner":"6v9a" }, { "sim":50.0, "partner":"3zpp" }, - { - "sim":50.0, - "partner":"7lr2" - }, { "sim":50.0, "partner":"7lr6" @@ -843614,11 +846781,7 @@ }, { "sim":50.0, - "partner":"6mp7" - }, - { - "sim":50.0, - "partner":"6mpa" + "partner":"7lr2" }, { "sim":50.0, @@ -843638,19 +846801,23 @@ }, { "sim":50.0, - "partner":"4buc" + "partner":"6mp7" }, { "sim":50.0, - "partner":"5upl" + "partner":"6mpa" }, { "sim":50.0, - "partner":"3qau" + "partner":"4buc" }, { "sim":50.0, - "partner":"9buj" + "partner":"5upl" + }, + { + "sim":50.0, + "partner":"3qau" }, { "sim":50.0, @@ -843662,7 +846829,7 @@ }, { "sim":50.0, - "partner":"5v1s" + "partner":"9buj" }, { "sim":50.0, @@ -843674,12 +846841,16 @@ }, { "sim":50.0, - "partner":"4j7c" + "partner":"5v1s" }, { "sim":50.0, "partner":"7xb5" }, + { + "sim":50.0, + "partner":"4j7c" + }, { "sim":50.0, "partner":"8tfb" @@ -843698,19 +846869,19 @@ }, { "sim":50.0, - "partner":"8vik" + "partner":"8vih" }, { "sim":50.0, - "partner":"8vil" + "partner":"8vii" }, { "sim":50.0, - "partner":"8vih" + "partner":"8vik" }, { "sim":50.0, - "partner":"8vii" + "partner":"8vil" }, { "sim":50.0, @@ -843718,19 +846889,19 @@ }, { "sim":50.0, - "partner":"6oi9" + "partner":"2gpw" }, { "sim":50.0, - "partner":"2gpw" + "partner":"6oi9" }, { "sim":50.0, - "partner":"6wiu" + "partner":"3tai" }, { "sim":50.0, - "partner":"3tai" + "partner":"6wiu" }, { "sim":50.0, @@ -843804,10 +846975,6 @@ "sim":50.0, "partner":"5jjq" }, - { - "sim":50.0, - "partner":"5wm2" - }, { "sim":50.0, "partner":"5wm3" @@ -843830,11 +846997,11 @@ }, { "sim":50.0, - "partner":"6j1f" + "partner":"5wm2" }, { "sim":50.0, - "partner":"6j1e" + "partner":"6j1f" }, { "sim":50.0, @@ -843856,6 +847023,10 @@ "sim":50.0, "partner":"6j0p" }, + { + "sim":50.0, + "partner":"6j1e" + }, { "sim":50.0, "partner":"5apn" @@ -843882,16 +847053,12 @@ }, { "sim":50.0, - "partner":"5uw0" + "partner":"5uw1" }, { "sim":50.0, "partner":"5vnc" }, - { - "sim":50.0, - "partner":"5uw1" - }, { "sim":50.0, "partner":"5uw4" @@ -843902,7 +847069,7 @@ }, { "sim":50.0, - "partner":"3rsz" + "partner":"5uw0" }, { "sim":50.0, @@ -843932,6 +847099,10 @@ "sim":50.0, "partner":"3nch" }, + { + "sim":50.0, + "partner":"3rsz" + }, { "sim":50.0, "partner":"2d73" @@ -844043,11 +847214,11 @@ ], "subtitle":"Crystal structure of borneoldehydrogenase ancestor n39", "tags":[ + "rossmann-like fold", "alcohol", - "terpenoid", + "oxidoreductase", "borneol", - "rossmann-like fold", - "oxidoreductase" + "terpenoid" ], "keywords":[ "description", @@ -844088,19 +847259,19 @@ }, { "sim":51.0, - "partner":"8c66" + "partner":"8adx" }, { "sim":51.0, - "partner":"8adx" + "partner":"8c66" }, { "sim":51.0, - "partner":"8v2w" + "partner":"8v09" }, { "sim":51.0, - "partner":"8v09" + "partner":"8v2w" }, { "sim":51.0, @@ -844112,15 +847283,15 @@ }, { "sim":50.0, - "partner":"8qae" + "partner":"8qad" }, { "sim":50.0, - "partner":"8qad" + "partner":"8qae" }, { "sim":50.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":50.0, @@ -844128,15 +847299,15 @@ }, { "sim":50.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":50.0, - "partner":"8w08" + "partner":"8w06" }, { "sim":50.0, - "partner":"8w05" + "partner":"8v0a" } ], "seq_thr_sim_natural":[ @@ -844266,11 +847437,11 @@ }, { "sim":141.0, - "partner":"6pei" + "partner":"6pej" }, { "sim":141.0, - "partner":"6pej" + "partner":"6pei" }, { "sim":138.0, @@ -844286,11 +847457,11 @@ }, { "sim":136.0, - "partner":"6ixm" + "partner":"5x8h" }, { "sim":136.0, - "partner":"5x8h" + "partner":"6ixm" }, { "sim":135.0, @@ -844322,11 +847493,11 @@ }, { "sim":133.0, - "partner":"5tii" + "partner":"5thq" }, { "sim":133.0, - "partner":"5thq" + "partner":"5tii" }, { "sim":132.0, @@ -844340,10 +847511,6 @@ "sim":131.0, "partner":"1g6k" }, - { - "sim":131.0, - "partner":"7b81" - }, { "sim":131.0, "partner":"7do5" @@ -844356,6 +847523,10 @@ "sim":131.0, "partner":"7do7" }, + { + "sim":131.0, + "partner":"7b81" + }, { "sim":131.0, "partner":"4jro" @@ -844398,11 +847569,11 @@ }, { "sim":129.0, - "partner":"4i5g" + "partner":"6y0z" }, { "sim":129.0, - "partner":"6y0z" + "partner":"4i5g" }, { "sim":129.0, @@ -844426,11 +847597,11 @@ }, { "sim":128.0, - "partner":"8y7r" + "partner":"8y83" }, { "sim":128.0, - "partner":"8y83" + "partner":"8y7r" }, { "sim":128.0, @@ -844502,7 +847673,7 @@ }, { "sim":123.0, - "partner":"8y46" + "partner":"8y4b" }, { "sim":123.0, @@ -844510,7 +847681,7 @@ }, { "sim":123.0, - "partner":"8y4b" + "partner":"8y46" }, { "sim":123.0, @@ -844524,10 +847695,6 @@ "sim":122.0, "partner":"7ejj" }, - { - "sim":122.0, - "partner":"7ejh" - }, { "sim":122.0, "partner":"7eji" @@ -844538,12 +847705,16 @@ }, { "sim":122.0, - "partner":"6xew" + "partner":"7ejh" }, { "sim":122.0, "partner":"6vsp" }, + { + "sim":122.0, + "partner":"6xew" + }, { "sim":122.0, "partner":"4is2" @@ -844586,27 +847757,15 @@ }, { "sim":121.0, - "partner":"3jq9" - }, - { - "sim":121.0, - "partner":"4cm3" - }, - { - "sim":121.0, - "partner":"4cmb" - }, - { - "sim":121.0, - "partner":"5jcj" + "partner":"2yhi" }, { "sim":121.0, - "partner":"6gdp" + "partner":"3bmc" }, { "sim":121.0, - "partner":"6rx0" + "partner":"3jqa" }, { "sim":121.0, @@ -844618,35 +847777,35 @@ }, { "sim":121.0, - "partner":"6gcl" + "partner":"4cm4" }, { "sim":121.0, - "partner":"2yhi" + "partner":"4cmc" }, { "sim":121.0, - "partner":"3bmc" + "partner":"5jcj" }, { "sim":121.0, - "partner":"4cm4" + "partner":"5k6a" }, { "sim":121.0, - "partner":"4cmc" + "partner":"6gcp" }, { "sim":121.0, - "partner":"5k6a" + "partner":"8of2" }, { "sim":121.0, - "partner":"3jqa" + "partner":"6gcq" }, { "sim":121.0, - "partner":"6gcp" + "partner":"6gd0" }, { "sim":121.0, @@ -844666,31 +847825,31 @@ }, { "sim":121.0, - "partner":"6gcq" + "partner":"4clr" }, { "sim":121.0, - "partner":"6gd0" + "partner":"4cme" }, { "sim":121.0, - "partner":"4clr" + "partner":"3bmo" }, { "sim":121.0, - "partner":"4cme" + "partner":"4cm6" }, { "sim":121.0, - "partner":"3bmo" + "partner":"3jqc" }, { "sim":121.0, - "partner":"4cm6" + "partner":"6gex" }, { "sim":121.0, - "partner":"3jqc" + "partner":"6tbx" }, { "sim":121.0, @@ -844714,11 +847873,7 @@ }, { "sim":121.0, - "partner":"6gex" - }, - { - "sim":121.0, - "partner":"6tbx" + "partner":"6rx6" }, { "sim":121.0, @@ -844734,35 +847889,35 @@ }, { "sim":121.0, - "partner":"6rx6" + "partner":"6gey" }, { "sim":121.0, - "partner":"5jdi" + "partner":"6hnc" }, { "sim":121.0, - "partner":"3gn2" + "partner":"5jdi" }, { "sim":121.0, - "partner":"4cle" + "partner":"3gn2" }, { "sim":121.0, - "partner":"6gey" + "partner":"4cle" }, { "sim":121.0, - "partner":"6hnc" + "partner":"4clx" }, { "sim":121.0, - "partner":"4clx" + "partner":"4cm8" }, { "sim":121.0, - "partner":"4cm8" + "partner":"7opj" }, { "sim":121.0, @@ -844774,7 +847929,7 @@ }, { "sim":121.0, - "partner":"7opj" + "partner":"6gd4" }, { "sim":121.0, @@ -844788,10 +847943,6 @@ "sim":121.0, "partner":"5jcx" }, - { - "sim":121.0, - "partner":"6gd4" - }, { "sim":121.0, "partner":"4clh" @@ -844810,11 +847961,11 @@ }, { "sim":121.0, - "partner":"4cmj" + "partner":"6hnr" }, { "sim":121.0, - "partner":"8of2" + "partner":"4cmj" }, { "sim":121.0, @@ -844822,12 +847973,16 @@ }, { "sim":121.0, - "partner":"6hnr" + "partner":"6how" }, { "sim":121.0, "partner":"4cma" }, + { + "sim":121.0, + "partner":"6gdo" + }, { "sim":121.0, "partner":"2x9g" @@ -844846,7 +848001,7 @@ }, { "sim":121.0, - "partner":"6how" + "partner":"6rx0" }, { "sim":121.0, @@ -844854,7 +848009,23 @@ }, { "sim":121.0, - "partner":"6gdo" + "partner":"4cm3" + }, + { + "sim":121.0, + "partner":"4cmb" + }, + { + "sim":121.0, + "partner":"6gdp" + }, + { + "sim":121.0, + "partner":"3jq9" + }, + { + "sim":121.0, + "partner":"6gcl" }, { "sim":121.0, @@ -844900,14 +848071,6 @@ "sim":120.0, "partner":"1yde" }, - { - "sim":120.0, - "partner":"6zde" - }, - { - "sim":120.0, - "partner":"5en4" - }, { "sim":120.0, "partner":"6zr6" @@ -844918,23 +848081,19 @@ }, { "sim":120.0, - "partner":"6zra" - }, - { - "sim":120.0, - "partner":"6zdi" + "partner":"5en4" }, { "sim":120.0, - "partner":"5o6o" + "partner":"6zra" }, { "sim":120.0, - "partner":"5o6x" + "partner":"6zdi" }, { "sim":120.0, - "partner":"6qck" + "partner":"6zde" }, { "sim":120.0, @@ -844962,11 +848121,11 @@ }, { "sim":120.0, - "partner":"5o7c" + "partner":"6hno" }, { "sim":120.0, - "partner":"6hno" + "partner":"5o7c" }, { "sim":120.0, @@ -844982,11 +848141,11 @@ }, { "sim":120.0, - "partner":"5ics" + "partner":"6ffb" }, { "sim":120.0, - "partner":"6ffb" + "partner":"5ics" }, { "sim":120.0, @@ -845000,13 +848159,25 @@ "sim":120.0, "partner":"5l7y" }, + { + "sim":120.0, + "partner":"6gtu" + }, { "sim":120.0, "partner":"5jsf" }, { "sim":120.0, - "partner":"6gtu" + "partner":"6qck" + }, + { + "sim":120.0, + "partner":"5o6o" + }, + { + "sim":120.0, + "partner":"5o6x" }, { "sim":119.0, @@ -845034,7 +848205,7 @@ }, { "sim":118.0, - "partner":"7a2b" + "partner":"6h07" }, { "sim":118.0, @@ -845042,15 +848213,15 @@ }, { "sim":118.0, - "partner":"6h07" + "partner":"6h1m" }, { "sim":118.0, - "partner":"6h1m" + "partner":"1nxq" }, { "sim":118.0, - "partner":"1nxq" + "partner":"7a2b" }, { "sim":117.0, @@ -845082,15 +848253,15 @@ }, { "sim":116.0, - "partner":"2dte" + "partner":"2dtx" }, { "sim":116.0, - "partner":"2dtx" + "partner":"2dtd" }, { "sim":116.0, - "partner":"2dtd" + "partner":"2dte" }, { "sim":116.0, @@ -845174,15 +848345,15 @@ }, { "sim":111.0, - "partner":"2zat" + "partner":"5ojg" }, { "sim":111.0, - "partner":"5ojg" + "partner":"5oji" }, { "sim":111.0, - "partner":"5oji" + "partner":"2zat" }, { "sim":111.0, @@ -845226,11 +848397,11 @@ }, { "sim":110.0, - "partner":"8pa1" + "partner":"8pa2" }, { "sim":110.0, - "partner":"8pa2" + "partner":"8pa1" }, { "sim":110.0, @@ -845286,11 +848457,11 @@ }, { "sim":108.0, - "partner":"5cdy" + "partner":"5cej" }, { "sim":108.0, - "partner":"5cej" + "partner":"5cdy" }, { "sim":108.0, @@ -845314,11 +848485,11 @@ }, { "sim":107.0, - "partner":"6t6p" + "partner":"6t6n" }, { "sim":107.0, - "partner":"6t6n" + "partner":"6t6p" }, { "sim":107.0, @@ -845338,11 +848509,11 @@ }, { "sim":107.0, - "partner":"8dt1" + "partner":"4trr" }, { "sim":107.0, - "partner":"4trr" + "partner":"8dt1" }, { "sim":106.0, @@ -845410,15 +848581,15 @@ }, { "sim":105.0, - "partner":"4qec" + "partner":"4qed" }, { "sim":105.0, - "partner":"4qed" + "partner":"5end" }, { "sim":105.0, - "partner":"5end" + "partner":"4qec" }, { "sim":105.0, @@ -845514,15 +848685,15 @@ }, { "sim":104.0, - "partner":"6k8s" + "partner":"6k8t" }, { "sim":104.0, - "partner":"6k8t" + "partner":"6k8u" }, { "sim":104.0, - "partner":"6k8u" + "partner":"6k8s" }, { "sim":103.0, @@ -845702,11 +848873,11 @@ }, { "sim":99.0, - "partner":"3gk3" + "partner":"5vt6" }, { "sim":99.0, - "partner":"5vt6" + "partner":"3gk3" }, { "sim":99.0, @@ -845826,11 +848997,11 @@ }, { "sim":97.0, - "partner":"8cbk" + "partner":"8cbl" }, { "sim":97.0, - "partner":"8cbl" + "partner":"8rr3" }, { "sim":97.0, @@ -845844,10 +849015,22 @@ "sim":97.0, "partner":"8cbm" }, + { + "sim":97.0, + "partner":"8rr4" + }, { "sim":97.0, "partner":"1so8" }, + { + "sim":97.0, + "partner":"8cbk" + }, + { + "sim":97.0, + "partner":"8rr1" + }, { "sim":97.0, "partner":"3ak4" @@ -845882,11 +849065,11 @@ }, { "sim":97.0, - "partner":"4jqc" + "partner":"4jx8" }, { "sim":97.0, - "partner":"4jx8" + "partner":"4jqc" }, { "sim":97.0, @@ -845910,11 +849093,11 @@ }, { "sim":96.0, - "partner":"8eh2" + "partner":"8gbb" }, { "sim":96.0, - "partner":"8gbb" + "partner":"8eh2" }, { "sim":96.0, @@ -845926,11 +849109,11 @@ }, { "sim":96.0, - "partner":"6pzm" + "partner":"6pzn" }, { "sim":96.0, - "partner":"6pzn" + "partner":"6pzm" }, { "sim":96.0, @@ -845952,10 +849135,6 @@ "sim":96.0, "partner":"3uve" }, - { - "sim":95.0, - "partner":"8jfg" - }, { "sim":95.0, "partner":"8jfh" @@ -845970,11 +849149,11 @@ }, { "sim":95.0, - "partner":"8hs9" + "partner":"8jfg" }, { "sim":95.0, - "partner":"8hs5" + "partner":"8hs9" }, { "sim":95.0, @@ -845984,6 +849163,10 @@ "sim":95.0, "partner":"8hdn" }, + { + "sim":95.0, + "partner":"8hs5" + }, { "sim":95.0, "partner":"3gaf" @@ -846016,6 +849199,10 @@ "sim":95.0, "partner":"5h5x" }, + { + "sim":95.0, + "partner":"8xvn" + }, { "sim":95.0, "partner":"5ovl" @@ -846034,11 +849221,11 @@ }, { "sim":94.0, - "partner":"8hs4" + "partner":"8hs6" }, { "sim":94.0, - "partner":"8hs6" + "partner":"8hs4" }, { "sim":94.0, @@ -846082,11 +849269,11 @@ }, { "sim":94.0, - "partner":"8hfj" + "partner":"8hfk" }, { "sim":94.0, - "partner":"8hfk" + "partner":"8hfj" }, { "sim":94.0, @@ -846150,23 +849337,23 @@ }, { "sim":92.0, - "partner":"6t60" + "partner":"6t65" }, { "sim":92.0, - "partner":"1edo" + "partner":"2cdh" }, { "sim":92.0, - "partner":"2cdh" + "partner":"1edo" }, { "sim":92.0, - "partner":"6t65" + "partner":"6t62" }, { "sim":92.0, - "partner":"6t62" + "partner":"6t60" }, { "sim":92.0, @@ -846216,10 +849403,6 @@ "sim":91.0, "partner":"5b4t" }, - { - "sim":91.0, - "partner":"1e6w" - }, { "sim":91.0, "partner":"5b4u" @@ -846230,7 +849413,7 @@ }, { "sim":91.0, - "partner":"4pn3" + "partner":"1e6w" }, { "sim":91.0, @@ -846238,11 +849421,7 @@ }, { "sim":91.0, - "partner":"4bnv" - }, - { - "sim":91.0, - "partner":"4bo3" + "partner":"4pn3" }, { "sim":91.0, @@ -846312,6 +849491,14 @@ "sim":91.0, "partner":"4bo2" }, + { + "sim":91.0, + "partner":"4bnv" + }, + { + "sim":91.0, + "partner":"4bo3" + }, { "sim":91.0, "partner":"1g0o" @@ -846486,11 +849673,11 @@ }, { "sim":86.0, - "partner":"7dll" + "partner":"7dmg" }, { "sim":86.0, - "partner":"7dmg" + "partner":"7dll" }, { "sim":86.0, @@ -846578,11 +849765,11 @@ }, { "sim":84.0, - "partner":"3ppi" + "partner":"3svt" }, { "sim":84.0, - "partner":"3svt" + "partner":"3ppi" }, { "sim":84.0, @@ -846604,10 +849791,6 @@ "sim":83.0, "partner":"9jdt" }, - { - "sim":83.0, - "partner":"6gck" - }, { "sim":83.0, "partner":"4wcd" @@ -846638,11 +849821,11 @@ }, { "sim":83.0, - "partner":"5vml" + "partner":"6gck" }, { "sim":83.0, - "partner":"3zv4" + "partner":"5vml" }, { "sim":83.0, @@ -846664,6 +849847,10 @@ "sim":83.0, "partner":"3zv3" }, + { + "sim":83.0, + "partner":"3zv4" + }, { "sim":83.0, "partner":"4rgb" @@ -846742,24 +849929,12 @@ }, { "sim":81.0, - "partner":"5coq" - }, - { - "sim":81.0, - "partner":"5cpb" - }, - { - "sim":81.0, - "partner":"5mtr" + "partner":"4oxk" }, { "sim":81.0, "partner":"5ugt" }, - { - "sim":81.0, - "partner":"4oxk" - }, { "sim":81.0, "partner":"5ugu" @@ -846770,15 +849945,15 @@ }, { "sim":81.0, - "partner":"4oxn" + "partner":"6yuu" }, { "sim":81.0, - "partner":"4oyr" + "partner":"4oxn" }, { "sim":81.0, - "partner":"6yuu" + "partner":"4oyr" }, { "sim":81.0, @@ -846804,10 +849979,22 @@ "sim":81.0, "partner":"5cp8" }, + { + "sim":81.0, + "partner":"5mtr" + }, { "sim":81.0, "partner":"5ugs" }, + { + "sim":81.0, + "partner":"5cpb" + }, + { + "sim":81.0, + "partner":"5coq" + }, { "sim":80.0, "partner":"2ehd" @@ -846960,10 +850147,6 @@ "sim":77.0, "partner":"3uic" }, - { - "sim":77.0, - "partner":"4j3f" - }, { "sim":77.0, "partner":"4j4t" @@ -846976,6 +850159,10 @@ "sim":77.0, "partner":"4j1n" }, + { + "sim":77.0, + "partner":"4j3f" + }, { "sim":77.0, "partner":"3rku" @@ -847006,11 +850193,11 @@ }, { "sim":76.0, - "partner":"8cwl" + "partner":"3icc" }, { "sim":76.0, - "partner":"3icc" + "partner":"8cwl" }, { "sim":76.0, @@ -847058,11 +850245,11 @@ }, { "sim":74.0, - "partner":"3tpc" + "partner":"3tl3" }, { "sim":74.0, - "partner":"3tl3" + "partner":"3tpc" }, { "sim":74.0, @@ -847090,11 +850277,11 @@ }, { "sim":73.0, - "partner":"3vzp" + "partner":"3vzs" }, { "sim":73.0, - "partner":"3vzs" + "partner":"3vzp" }, { "sim":73.0, @@ -847110,15 +850297,15 @@ }, { "sim":72.0, - "partner":"1x7g" + "partner":"1x7h" }, { "sim":72.0, - "partner":"1x7h" + "partner":"1xr3" }, { "sim":72.0, - "partner":"1xr3" + "partner":"1x7g" }, { "sim":72.0, @@ -847206,19 +850393,19 @@ }, { "sim":71.0, - "partner":"8aeo" + "partner":"8aer" }, { "sim":71.0, - "partner":"8aer" + "partner":"8aeo" }, { "sim":70.0, - "partner":"5ilg" + "partner":"5ilo" }, { "sim":70.0, - "partner":"5ilo" + "partner":"5ilg" }, { "sim":70.0, @@ -847280,10 +850467,6 @@ "sim":68.0, "partner":"6xnb" }, - { - "sim":68.0, - "partner":"6yq0" - }, { "sim":68.0, "partner":"6yq3" @@ -847298,15 +850481,15 @@ }, { "sim":68.0, - "partner":"3iah" + "partner":"6yq0" }, { "sim":68.0, - "partner":"3ojf" + "partner":"3iah" }, { "sim":68.0, - "partner":"5ycs" + "partner":"3ojf" }, { "sim":68.0, @@ -847320,6 +850503,10 @@ "sim":68.0, "partner":"5ycr" }, + { + "sim":68.0, + "partner":"5ycs" + }, { "sim":68.0, "partner":"5kwe" @@ -847346,15 +850533,15 @@ }, { "sim":68.0, - "partner":"8wov" + "partner":"8wop" }, { "sim":68.0, - "partner":"8wow" + "partner":"8wov" }, { "sim":68.0, - "partner":"8wop" + "partner":"8wow" }, { "sim":67.0, @@ -847472,10 +850659,6 @@ "sim":63.0, "partner":"2bel" }, - { - "sim":63.0, - "partner":"2y6r" - }, { "sim":63.0, "partner":"4a99" @@ -847496,6 +850679,10 @@ "sim":63.0, "partner":"2y6q" }, + { + "sim":63.0, + "partner":"2y6r" + }, { "sim":63.0, "partner":"2xyo" @@ -847526,11 +850713,11 @@ }, { "sim":61.0, - "partner":"3gy0" + "partner":"3f5s" }, { "sim":61.0, - "partner":"3f5s" + "partner":"3gy0" }, { "sim":61.0, @@ -847574,15 +850761,15 @@ }, { "sim":61.0, - "partner":"2pzm" + "partner":"2pzk" }, { "sim":61.0, - "partner":"2pzk" + "partner":"2pzl" }, { "sim":61.0, - "partner":"2pzl" + "partner":"2pzm" }, { "sim":61.0, @@ -847600,17 +850787,13 @@ "sim":61.0, "partner":"5hru" }, - { - "sim":60.0, - "partner":"3f1k" - }, { "sim":60.0, "partner":"3f1l" }, { "sim":60.0, - "partner":"7btm" + "partner":"3f1k" }, { "sim":60.0, @@ -847618,11 +850801,11 @@ }, { "sim":60.0, - "partner":"7us5" + "partner":"7btm" }, { "sim":60.0, - "partner":"2r0p" + "partner":"7us5" }, { "sim":60.0, @@ -847644,6 +850827,10 @@ "sim":60.0, "partner":"3ept" }, + { + "sim":60.0, + "partner":"2r0p" + }, { "sim":59.0, "partner":"3umf" @@ -847668,14 +850855,6 @@ "sim":59.0, "partner":"8g9m" }, - { - "sim":59.0, - "partner":"5ds3" - }, - { - "sim":59.0, - "partner":"6bhv" - }, { "sim":59.0, "partner":"6ntu" @@ -847690,11 +850869,11 @@ }, { "sim":59.0, - "partner":"6nrf" + "partner":"8fyz" }, { "sim":59.0, - "partner":"8fyz" + "partner":"6nrf" }, { "sim":59.0, @@ -847714,7 +850893,11 @@ }, { "sim":59.0, - "partner":"7fcm" + "partner":"6bhv" + }, + { + "sim":59.0, + "partner":"5ds3" }, { "sim":59.0, @@ -847724,6 +850907,10 @@ "sim":59.0, "partner":"7fc8" }, + { + "sim":59.0, + "partner":"7fcm" + }, { "sim":59.0, "partner":"6wg9" @@ -847766,23 +850953,23 @@ }, { "sim":59.0, - "partner":"7aqu" + "partner":"7cu0" }, { "sim":59.0, - "partner":"7aqv" + "partner":"7cu1" }, { "sim":59.0, - "partner":"7cu0" + "partner":"7cu2" }, { "sim":59.0, - "partner":"7cu1" + "partner":"7aqu" }, { "sim":59.0, - "partner":"7cu2" + "partner":"7aqv" }, { "sim":58.0, @@ -847856,10 +851043,6 @@ "sim":58.0, "partner":"7cgv" }, - { - "sim":58.0, - "partner":"4wlo" - }, { "sim":58.0, "partner":"4wle" @@ -847880,6 +851063,10 @@ "sim":58.0, "partner":"4wln" }, + { + "sim":58.0, + "partner":"4wlo" + }, { "sim":58.0, "partner":"2pzj" @@ -847984,21 +851171,17 @@ "sim":57.0, "partner":"5mln" }, - { - "sim":57.0, - "partner":"8jfn" - }, { "sim":57.0, "partner":"8jfm" }, { "sim":57.0, - "partner":"8jfj" + "partner":"8jfn" }, { "sim":57.0, - "partner":"3dbp" + "partner":"8jfj" }, { "sim":57.0, @@ -848016,6 +851199,10 @@ "sim":57.0, "partner":"3g3m" }, + { + "sim":57.0, + "partner":"3dbp" + }, { "sim":57.0, "partner":"6wb7" @@ -848082,19 +851269,15 @@ }, { "sim":57.0, - "partner":"2gps" - }, - { - "sim":57.0, - "partner":"6oi9" + "partner":"2gpw" }, { "sim":57.0, - "partner":"2gpw" + "partner":"2gps" }, { "sim":57.0, - "partner":"6uuv" + "partner":"6oi9" }, { "sim":57.0, @@ -848102,7 +851285,7 @@ }, { "sim":57.0, - "partner":"6p00" + "partner":"6uuv" }, { "sim":57.0, @@ -848132,6 +851315,10 @@ "sim":57.0, "partner":"2e4g" }, + { + "sim":57.0, + "partner":"6p00" + }, { "sim":57.0, "partner":"6a37" @@ -848184,10 +851371,6 @@ "sim":56.0, "partner":"8uw4" }, - { - "sim":56.0, - "partner":"5zrk" - }, { "sim":56.0, "partner":"5zrl" @@ -848216,6 +851399,10 @@ "sim":56.0, "partner":"5zri" }, + { + "sim":56.0, + "partner":"5zrk" + }, { "sim":56.0, "partner":"5uqw" @@ -848256,10 +851443,6 @@ "sim":56.0, "partner":"2pd4" }, - { - "sim":56.0, - "partner":"5qij" - }, { "sim":56.0, "partner":"5pgz" @@ -848276,6 +851459,10 @@ "sim":56.0, "partner":"4k26" }, + { + "sim":56.0, + "partner":"5qij" + }, { "sim":56.0, "partner":"6dli" @@ -848318,27 +851505,27 @@ }, { "sim":56.0, - "partner":"6fm0" + "partner":"6fm3" }, { "sim":56.0, - "partner":"6rm2" + "partner":"6flf" }, { "sim":56.0, - "partner":"6fko" + "partner":"6fm0" }, { "sim":56.0, - "partner":"6fm1" + "partner":"6rm2" }, { "sim":56.0, - "partner":"6fm3" + "partner":"6fko" }, { "sim":56.0, - "partner":"6flf" + "partner":"6fm1" }, { "sim":56.0, @@ -848422,11 +851609,11 @@ }, { "sim":55.0, - "partner":"6ze0" + "partner":"6zdz" }, { "sim":55.0, - "partner":"6zdz" + "partner":"6ze0" }, { "sim":55.0, @@ -848436,14 +851623,6 @@ "sim":55.0, "partner":"3p8k" }, - { - "sim":55.0, - "partner":"6mql" - }, - { - "sim":55.0, - "partner":"6mq9" - }, { "sim":55.0, "partner":"3grr" @@ -848470,23 +851649,23 @@ }, { "sim":55.0, - "partner":"3ta4" + "partner":"6mql" }, { "sim":55.0, - "partner":"3t9w" + "partner":"6mq9" }, { "sim":55.0, - "partner":"5ybr" + "partner":"3t9w" }, { "sim":55.0, - "partner":"5ybs" + "partner":"3ta4" }, { "sim":55.0, - "partner":"5ybt" + "partner":"5ybs" }, { "sim":55.0, @@ -848494,12 +851673,16 @@ }, { "sim":55.0, - "partner":"5ybm" + "partner":"5ybt" }, { "sim":55.0, "partner":"6lrz" }, + { + "sim":55.0, + "partner":"5ybm" + }, { "sim":55.0, "partner":"5ybn" @@ -848516,6 +851699,10 @@ "sim":55.0, "partner":"5ybq" }, + { + "sim":55.0, + "partner":"5ybr" + }, { "sim":55.0, "partner":"6hrd" @@ -848542,19 +851729,19 @@ }, { "sim":55.0, - "partner":"7wzv" + "partner":"7wzx" }, { "sim":55.0, - "partner":"7wzx" + "partner":"7x0b" }, { "sim":55.0, - "partner":"7x0b" + "partner":"7wzv" }, { "sim":55.0, - "partner":"6pi5" + "partner":"6pi6" }, { "sim":55.0, @@ -848562,7 +851749,7 @@ }, { "sim":55.0, - "partner":"6pi6" + "partner":"6pi5" }, { "sim":55.0, @@ -848574,11 +851761,11 @@ }, { "sim":55.0, - "partner":"4zhs" + "partner":"4zic" }, { "sim":55.0, - "partner":"4zic" + "partner":"4zhs" }, { "sim":55.0, @@ -848588,10 +851775,6 @@ "sim":55.0, "partner":"6j39" }, - { - "sim":55.0, - "partner":"4lre" - }, { "sim":55.0, "partner":"4lrf" @@ -848624,6 +851807,10 @@ "sim":55.0, "partner":"4lrd" }, + { + "sim":55.0, + "partner":"4lre" + }, { "sim":55.0, "partner":"7nwr" @@ -848678,47 +851865,47 @@ }, { "sim":55.0, - "partner":"8iat" + "partner":"8iau" }, { "sim":55.0, - "partner":"8zly" + "partner":"8iav" }, { "sim":55.0, - "partner":"8iau" + "partner":"8zly" }, { "sim":55.0, - "partner":"8xw6" + "partner":"8iaw" }, { "sim":55.0, - "partner":"8iav" + "partner":"8iax" }, { "sim":55.0, - "partner":"8xw7" + "partner":"8xw6" }, { "sim":55.0, - "partner":"8xw8" + "partner":"8xw7" }, { "sim":55.0, - "partner":"8iaw" + "partner":"8ias" }, { "sim":55.0, - "partner":"8iax" + "partner":"8xw8" }, { "sim":55.0, - "partner":"8xw9" + "partner":"8iat" }, { "sim":55.0, - "partner":"8ias" + "partner":"8xw9" }, { "sim":55.0, @@ -848802,27 +851989,27 @@ }, { "sim":54.0, - "partner":"7mnq" + "partner":"7mns" }, { "sim":54.0, - "partner":"7mnr" + "partner":"7mnt" }, { "sim":54.0, - "partner":"7mns" + "partner":"7mnu" }, { "sim":54.0, - "partner":"7mnt" + "partner":"7mnv" }, { "sim":54.0, - "partner":"7mnu" + "partner":"7mnq" }, { "sim":54.0, - "partner":"7mnv" + "partner":"7mnr" }, { "sim":54.0, @@ -848858,11 +852045,11 @@ }, { "sim":54.0, - "partner":"4rdh" + "partner":"4rdi" }, { "sim":54.0, - "partner":"4rdi" + "partner":"4rdh" }, { "sim":54.0, @@ -848958,11 +852145,11 @@ }, { "sim":54.0, - "partner":"6wa9" + "partner":"6wa6" }, { "sim":54.0, - "partner":"6wa6" + "partner":"6wa9" }, { "sim":54.0, @@ -848976,10 +852163,6 @@ "sim":54.0, "partner":"5xwb" }, - { - "sim":54.0, - "partner":"6bzn" - }, { "sim":54.0, "partner":"6bzz" @@ -849000,6 +852183,10 @@ "sim":54.0, "partner":"6bzi" }, + { + "sim":54.0, + "partner":"6bzn" + }, { "sim":54.0, "partner":"3bdl" @@ -849082,15 +852269,15 @@ }, { "sim":53.0, - "partner":"5c7p" + "partner":"4kpc" }, { "sim":53.0, - "partner":"4kpc" + "partner":"3w95" }, { "sim":53.0, - "partner":"3w95" + "partner":"5c7p" }, { "sim":53.0, @@ -849206,23 +852393,23 @@ }, { "sim":53.0, - "partner":"8vip" + "partner":"8vit" }, { "sim":53.0, - "partner":"8viq" + "partner":"3c6a" }, { "sim":53.0, - "partner":"8vir" + "partner":"8vip" }, { "sim":53.0, - "partner":"8vit" + "partner":"8viq" }, { "sim":53.0, - "partner":"3c6a" + "partner":"8vir" }, { "sim":53.0, @@ -849266,7 +852453,7 @@ }, { "sim":53.0, - "partner":"2wyv" + "partner":"2wyw" }, { "sim":53.0, @@ -849274,15 +852461,15 @@ }, { "sim":53.0, - "partner":"2wyw" + "partner":"1ulu" }, { "sim":53.0, - "partner":"1ulu" + "partner":"2wyu" }, { "sim":53.0, - "partner":"2wyu" + "partner":"2wyv" }, { "sim":53.0, @@ -849298,15 +852485,15 @@ }, { "sim":53.0, - "partner":"2rbe" + "partner":"3byz" }, { "sim":53.0, - "partner":"3byz" + "partner":"3ey4" }, { "sim":53.0, - "partner":"3ey4" + "partner":"2rbe" }, { "sim":53.0, @@ -849354,15 +852541,15 @@ }, { "sim":53.0, - "partner":"5zm4" + "partner":"5zm2" }, { "sim":53.0, - "partner":"5zm2" + "partner":"5zm3" }, { "sim":53.0, - "partner":"5zm3" + "partner":"5zm4" }, { "sim":53.0, @@ -849400,10 +852587,6 @@ "sim":53.0, "partner":"6k92" }, - { - "sim":53.0, - "partner":"3aio" - }, { "sim":53.0, "partner":"3aik" @@ -849420,6 +852603,10 @@ "sim":53.0, "partner":"3ain" }, + { + "sim":53.0, + "partner":"3aio" + }, { "sim":53.0, "partner":"3jrq" @@ -849454,15 +852641,15 @@ }, { "sim":53.0, - "partner":"8zj0" + "partner":"8zi8" }, { "sim":53.0, - "partner":"8zhy" + "partner":"8zj0" }, { "sim":53.0, - "partner":"8zi8" + "partner":"8zhy" }, { "sim":53.0, @@ -849518,15 +852705,15 @@ }, { "sim":53.0, - "partner":"6s0g" + "partner":"7bn6" }, { "sim":53.0, - "partner":"7bn6" + "partner":"6s23" }, { "sim":53.0, - "partner":"6s23" + "partner":"6s0g" }, { "sim":53.0, @@ -849552,14 +852739,6 @@ "sim":53.0, "partner":"4eay" }, - { - "sim":53.0, - "partner":"2ca0" - }, - { - "sim":53.0, - "partner":"4b7s" - }, { "sim":53.0, "partner":"2vz7" @@ -849606,11 +852785,11 @@ }, { "sim":53.0, - "partner":"7xbn" + "partner":"2ca0" }, { "sim":53.0, - "partner":"7xbo" + "partner":"4b7s" }, { "sim":53.0, @@ -849618,15 +852797,19 @@ }, { "sim":53.0, - "partner":"7m6u" + "partner":"7xbn" }, { "sim":53.0, - "partner":"5y9h" + "partner":"7xbo" }, { "sim":53.0, - "partner":"6oi8" + "partner":"7m6u" + }, + { + "sim":53.0, + "partner":"5y9h" }, { "sim":53.0, @@ -849664,6 +852847,10 @@ "sim":53.0, "partner":"6ojh" }, + { + "sim":53.0, + "partner":"6oi8" + }, { "sim":53.0, "partner":"7yzn" @@ -849680,10 +852867,6 @@ "sim":53.0, "partner":"7oze" }, - { - "sim":53.0, - "partner":"2cj9" - }, { "sim":53.0, "partner":"2cja" @@ -849696,6 +852879,10 @@ "sim":53.0, "partner":"2cjb" }, + { + "sim":53.0, + "partner":"2cj9" + }, { "sim":53.0, "partner":"5oy5" @@ -849722,16 +852909,12 @@ }, { "sim":53.0, - "partner":"5uw0" + "partner":"5uw1" }, { "sim":53.0, "partner":"5vnc" }, - { - "sim":53.0, - "partner":"5uw1" - }, { "sim":53.0, "partner":"5uw4" @@ -849742,7 +852925,7 @@ }, { "sim":53.0, - "partner":"3rsz" + "partner":"5uw0" }, { "sim":53.0, @@ -849774,7 +852957,7 @@ }, { "sim":53.0, - "partner":"7wlg" + "partner":"3rsz" }, { "sim":53.0, @@ -849804,6 +852987,10 @@ "sim":53.0, "partner":"7wjf" }, + { + "sim":53.0, + "partner":"7wlg" + }, { "sim":52.0, "partner":"8skx" @@ -849872,10 +853059,6 @@ "sim":52.0, "partner":"6cky" }, - { - "sim":52.0, - "partner":"6ebc" - }, { "sim":52.0, "partner":"6ebd" @@ -849890,7 +853073,7 @@ }, { "sim":52.0, - "partner":"5wqi" + "partner":"6ebc" }, { "sim":52.0, @@ -849904,6 +853087,10 @@ "sim":52.0, "partner":"5wqh" }, + { + "sim":52.0, + "partner":"5wqi" + }, { "sim":52.0, "partner":"4xx2" @@ -850038,11 +853225,11 @@ }, { "sim":52.0, - "partner":"7xrt" + "partner":"7xrv" }, { "sim":52.0, - "partner":"7xrv" + "partner":"7xrt" }, { "sim":52.0, @@ -850062,11 +853249,11 @@ }, { "sim":52.0, - "partner":"6ve6" + "partner":"7xbr" }, { "sim":52.0, - "partner":"7xbr" + "partner":"6ve6" }, { "sim":52.0, @@ -850102,11 +853289,11 @@ }, { "sim":52.0, - "partner":"7xif" + "partner":"7xig" }, { "sim":52.0, - "partner":"7xig" + "partner":"7xih" }, { "sim":52.0, @@ -850114,11 +853301,11 @@ }, { "sim":52.0, - "partner":"7xih" + "partner":"7xii" }, { "sim":52.0, - "partner":"7xii" + "partner":"7xif" }, { "sim":52.0, @@ -850140,10 +853327,6 @@ "sim":52.0, "partner":"6zjo" }, - { - "sim":52.0, - "partner":"3g3d" - }, { "sim":52.0, "partner":"3bvj" @@ -850160,6 +853343,10 @@ "sim":52.0, "partner":"4hkp" }, + { + "sim":52.0, + "partner":"3g3d" + }, { "sim":52.0, "partner":"1ynp" @@ -850176,14 +853363,6 @@ "sim":52.0, "partner":"4lrt" }, - { - "sim":52.0, - "partner":"5mit" - }, - { - "sim":52.0, - "partner":"5z75" - }, { "sim":52.0, "partner":"5mjk" @@ -850200,6 +853379,10 @@ "sim":52.0, "partner":"5miq" }, + { + "sim":52.0, + "partner":"5z75" + }, { "sim":52.0, "partner":"5mir" @@ -850210,15 +853393,19 @@ }, { "sim":52.0, - "partner":"5exi" + "partner":"5mit" }, { "sim":52.0, - "partner":"5exj" + "partner":"5exk" }, { "sim":52.0, - "partner":"5exk" + "partner":"5exi" + }, + { + "sim":52.0, + "partner":"5exj" }, { "sim":52.0, @@ -850326,11 +853513,11 @@ }, { "sim":52.0, - "partner":"8gqm" + "partner":"8gqf" }, { "sim":52.0, - "partner":"8gqf" + "partner":"8gqm" }, { "sim":52.0, @@ -850350,15 +853537,15 @@ }, { "sim":52.0, - "partner":"5dvi" + "partner":"5dvj" }, { "sim":52.0, - "partner":"5dvj" + "partner":"5dvf" }, { "sim":52.0, - "partner":"5dvf" + "partner":"5dvi" }, { "sim":52.0, @@ -850386,15 +853573,15 @@ }, { "sim":52.0, - "partner":"6v99" + "partner":"6v96" }, { "sim":52.0, - "partner":"6v9a" + "partner":"6v99" }, { "sim":52.0, - "partner":"6v96" + "partner":"6v9a" }, { "sim":52.0, @@ -850404,10 +853591,6 @@ "sim":52.0, "partner":"4zm3" }, - { - "sim":52.0, - "partner":"4acg" - }, { "sim":52.0, "partner":"4ach" @@ -850422,19 +853605,19 @@ }, { "sim":52.0, - "partner":"6psm" + "partner":"4acg" }, { "sim":52.0, - "partner":"6prm" + "partner":"6psm" }, { "sim":52.0, - "partner":"6pso" + "partner":"6prm" }, { "sim":52.0, - "partner":"6rk2" + "partner":"6pso" }, { "sim":52.0, @@ -850448,6 +853631,10 @@ "sim":52.0, "partner":"6rjm" }, + { + "sim":52.0, + "partner":"6rk2" + }, { "sim":52.0, "partner":"3vr1" @@ -850482,11 +853669,11 @@ }, { "sim":52.0, - "partner":"7jwf" + "partner":"7jw4" }, { "sim":52.0, - "partner":"7jw4" + "partner":"7jwf" }, { "sim":52.0, @@ -850546,11 +853733,11 @@ }, { "sim":51.0, - "partner":"2ese" + "partner":"2es6" }, { "sim":51.0, - "partner":"2es6" + "partner":"2ese" }, { "sim":51.0, @@ -850600,10 +853787,6 @@ "sim":51.0, "partner":"3hzq" }, - { - "sim":51.0, - "partner":"7p4y" - }, { "sim":51.0, "partner":"7p50" @@ -850620,6 +853803,10 @@ "sim":51.0, "partner":"7p4v" }, + { + "sim":51.0, + "partner":"7p4y" + }, { "sim":51.0, "partner":"5h34" @@ -850642,15 +853829,15 @@ }, { "sim":51.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":51.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":51.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":51.0, @@ -850714,15 +853901,15 @@ }, { "sim":51.0, - "partner":"8cga" + "partner":"6o20" }, { "sim":51.0, - "partner":"6o20" + "partner":"4dt4" }, { "sim":51.0, - "partner":"4dt4" + "partner":"8cga" }, { "sim":51.0, @@ -850750,7 +853937,7 @@ }, { "sim":51.0, - "partner":"5edd" + "partner":"8p8o" }, { "sim":51.0, @@ -850786,15 +853973,15 @@ }, { "sim":51.0, - "partner":"8p8o" + "partner":"1sm8" }, { "sim":51.0, - "partner":"1sm8" + "partner":"3hza" }, { "sim":51.0, - "partner":"3hza" + "partner":"5edd" }, { "sim":51.0, @@ -850862,11 +854049,11 @@ }, { "sim":51.0, - "partner":"4d70" + "partner":"8pwz" }, { "sim":51.0, - "partner":"8pwz" + "partner":"4d70" }, { "sim":51.0, @@ -850928,10 +854115,6 @@ "sim":51.0, "partner":"8tg4" }, - { - "sim":51.0, - "partner":"3l1u" - }, { "sim":51.0, "partner":"3l1v" @@ -850948,6 +854131,10 @@ "sim":51.0, "partner":"3esr" }, + { + "sim":51.0, + "partner":"3l1u" + }, { "sim":51.0, "partner":"5i2d" @@ -850966,23 +854153,23 @@ }, { "sim":51.0, - "partner":"4njh" + "partner":"4njj" }, { "sim":51.0, - "partner":"4nji" + "partner":"4njk" }, { "sim":51.0, - "partner":"4njj" + "partner":"4njg" }, { "sim":51.0, - "partner":"4njk" + "partner":"4njh" }, { "sim":51.0, - "partner":"4njg" + "partner":"4nji" }, { "sim":51.0, @@ -851008,29 +854195,17 @@ "sim":51.0, "partner":"6kft" }, - { - "sim":51.0, - "partner":"6a38" - }, { "sim":51.0, "partner":"6lq9" }, { "sim":51.0, - "partner":"6plj" - }, - { - "sim":51.0, - "partner":"3la7" - }, - { - "sim":51.0, - "partner":"3qu5" + "partner":"6a38" }, { "sim":51.0, - "partner":"3quq" + "partner":"6plj" }, { "sim":51.0, @@ -851078,15 +854253,19 @@ }, { "sim":51.0, - "partner":"6qe6" + "partner":"3qu5" }, { "sim":51.0, - "partner":"3ft5" + "partner":"3la7" }, { "sim":51.0, - "partner":"2xdx" + "partner":"3quq" + }, + { + "sim":51.0, + "partner":"6qe6" }, { "sim":51.0, @@ -851156,6 +854335,14 @@ "sim":51.0, "partner":"2xhx" }, + { + "sim":51.0, + "partner":"3ft5" + }, + { + "sim":51.0, + "partner":"2xdx" + }, { "sim":51.0, "partner":"8jms" @@ -851166,11 +854353,11 @@ }, { "sim":51.0, - "partner":"4ixt" + "partner":"8bat" }, { "sim":51.0, - "partner":"8bat" + "partner":"4ixt" }, { "sim":51.0, @@ -851188,17 +854375,13 @@ "sim":51.0, "partner":"2va1" }, - { - "sim":51.0, - "partner":"6ey1" - }, { "sim":51.0, "partner":"6f0w" }, { "sim":51.0, - "partner":"5h5a" + "partner":"6ey1" }, { "sim":51.0, @@ -851206,7 +854389,7 @@ }, { "sim":51.0, - "partner":"8twt" + "partner":"5h5a" }, { "sim":51.0, @@ -851216,6 +854399,10 @@ "sim":51.0, "partner":"8twn" }, + { + "sim":51.0, + "partner":"8twt" + }, { "sim":51.0, "partner":"6azq" @@ -851254,15 +854441,15 @@ }, { "sim":51.0, - "partner":"7d9v" + "partner":"7d8h" }, { "sim":51.0, - "partner":"7d8p" + "partner":"7d9v" }, { "sim":51.0, - "partner":"7d8h" + "partner":"7d8p" }, { "sim":51.0, @@ -851290,15 +854477,15 @@ }, { "sim":51.0, - "partner":"4m7t" + "partner":"6szg" }, { "sim":51.0, - "partner":"6szg" + "partner":"6szh" }, { "sim":51.0, - "partner":"6szh" + "partner":"4m7t" }, { "sim":51.0, @@ -851336,10 +854523,6 @@ "sim":51.0, "partner":"5ldb" }, - { - "sim":51.0, - "partner":"6ub7" - }, { "sim":51.0, "partner":"5lcd" @@ -851360,6 +854543,10 @@ "sim":51.0, "partner":"2ews" }, + { + "sim":51.0, + "partner":"6ub7" + }, { "sim":51.0, "partner":"4yqf" @@ -851384,10 +854571,6 @@ "sim":51.0, "partner":"4px9" }, - { - "sim":51.0, - "partner":"6wye" - }, { "sim":51.0, "partner":"6cb2" @@ -851402,15 +854585,15 @@ }, { "sim":51.0, - "partner":"2rhq" + "partner":"6wye" }, { "sim":51.0, - "partner":"2rhs" + "partner":"2rhq" }, { "sim":51.0, - "partner":"4rtl" + "partner":"2rhs" }, { "sim":51.0, @@ -851452,6 +854635,10 @@ "sim":51.0, "partner":"4rtk" }, + { + "sim":51.0, + "partner":"4rtl" + }, { "sim":51.0, "partner":"4x9x" @@ -851474,11 +854661,11 @@ }, { "sim":51.0, - "partner":"5uto" + "partner":"7scl" }, { "sim":51.0, - "partner":"7scl" + "partner":"5uto" }, { "sim":51.0, @@ -851486,11 +854673,11 @@ }, { "sim":51.0, - "partner":"1fg5" + "partner":"6xtu" }, { "sim":51.0, - "partner":"6xtu" + "partner":"1fg5" }, { "sim":51.0, @@ -851498,11 +854685,11 @@ }, { "sim":51.0, - "partner":"6y5x" + "partner":"6y5y" }, { "sim":51.0, - "partner":"6y5y" + "partner":"6y5x" }, { "sim":51.0, @@ -851510,15 +854697,15 @@ }, { "sim":51.0, - "partner":"7ag7" + "partner":"7ne2" }, { "sim":51.0, - "partner":"5a7y" + "partner":"7ag7" }, { "sim":51.0, - "partner":"7ne2" + "partner":"5a7y" }, { "sim":51.0, @@ -851528,17 +854715,13 @@ "sim":51.0, "partner":"3kck" }, - { - "sim":51.0, - "partner":"3iok" - }, { "sim":51.0, "partner":"6mhp" }, { "sim":51.0, - "partner":"3ggo" + "partner":"3iok" }, { "sim":51.0, @@ -851548,6 +854731,10 @@ "sim":51.0, "partner":"3ggg" }, + { + "sim":51.0, + "partner":"3ggo" + }, { "sim":51.0, "partner":"4xvc" @@ -851608,6 +854795,10 @@ "sim":51.0, "partner":"3pzv" }, + { + "sim":51.0, + "partner":"8qfb" + }, { "sim":51.0, "partner":"3rx2" @@ -851628,10 +854819,6 @@ "sim":51.0, "partner":"3v36" }, - { - "sim":51.0, - "partner":"8qfb" - }, { "sim":51.0, "partner":"3s3g" @@ -851706,11 +854893,11 @@ }, { "sim":51.0, - "partner":"7js3" + "partner":"8g5w" }, { "sim":51.0, - "partner":"8g5w" + "partner":"7js3" }, { "sim":51.0, @@ -851754,11 +854941,11 @@ }, { "sim":51.0, - "partner":"8phd" + "partner":"8phv" }, { "sim":51.0, - "partner":"8phv" + "partner":"8phd" }, { "sim":51.0, @@ -851812,14 +854999,6 @@ "sim":51.0, "partner":"1si7" }, - { - "sim":51.0, - "partner":"6vkk" - }, - { - "sim":51.0, - "partner":"6vkq" - }, { "sim":51.0, "partner":"3vaq" @@ -851828,37 +855007,29 @@ "sim":51.0, "partner":"3uq9" }, - { - "sim":51.0, - "partner":"4dc3" - }, { "sim":51.0, "partner":"6vko" }, { "sim":51.0, - "partner":"3uq6" - }, - { - "sim":51.0, - "partner":"6cdr" + "partner":"4dc3" }, { "sim":51.0, - "partner":"5zzx" + "partner":"6vkk" }, { "sim":51.0, - "partner":"6a0d" + "partner":"3uq6" }, { "sim":51.0, - "partner":"5zzy" + "partner":"6vkq" }, { "sim":51.0, - "partner":"6a0v" + "partner":"6cdr" }, { "sim":51.0, @@ -852002,15 +855173,27 @@ }, { "sim":51.0, - "partner":"8k2y" + "partner":"5zzx" }, { "sim":51.0, - "partner":"7ct4" + "partner":"6a0d" }, { "sim":51.0, - "partner":"5hxu" + "partner":"5zzy" + }, + { + "sim":51.0, + "partner":"6a0v" + }, + { + "sim":51.0, + "partner":"8k2y" + }, + { + "sim":51.0, + "partner":"7ct4" }, { "sim":51.0, @@ -852024,6 +855207,10 @@ "sim":51.0, "partner":"5hwe" }, + { + "sim":51.0, + "partner":"5hxu" + }, { "sim":51.0, "partner":"6a82" @@ -852058,11 +855245,11 @@ }, { "sim":51.0, - "partner":"3wkr" + "partner":"3wks" }, { "sim":51.0, - "partner":"3wks" + "partner":"3wkr" }, { "sim":51.0, @@ -852082,35 +855269,35 @@ }, { "sim":51.0, - "partner":"5du2" + "partner":"8czl" }, { "sim":51.0, - "partner":"8czl" + "partner":"8d0v" }, { "sim":51.0, - "partner":"8d0v" + "partner":"5du2" }, { "sim":51.0, - "partner":"6e9b" + "partner":"6e57" }, { "sim":51.0, - "partner":"7cl7" + "partner":"6l69" }, { "sim":51.0, - "partner":"7cl8" + "partner":"7cl7" }, { "sim":51.0, - "partner":"6e57" + "partner":"6e9b" }, { "sim":51.0, - "partner":"6l69" + "partner":"7cl8" }, { "sim":51.0, @@ -852140,17 +855327,13 @@ "sim":51.0, "partner":"7ljh" }, - { - "sim":51.0, - "partner":"4y1b" - }, { "sim":51.0, "partner":"7lji" }, { "sim":51.0, - "partner":"5cu7" + "partner":"4y1b" }, { "sim":51.0, @@ -852168,6 +855351,10 @@ "sim":51.0, "partner":"5cx4" }, + { + "sim":51.0, + "partner":"5cu7" + }, { "sim":51.0, "partner":"5kyo" @@ -852250,43 +855437,15 @@ }, { "sim":51.0, - "partner":"7viy" - }, - { - "sim":51.0, - "partner":"7f8t" - }, - { - "sim":51.0, - "partner":"7viz" - }, - { - "sim":51.0, - "partner":"7ycm" - }, - { - "sim":51.0, - "partner":"7yee" - }, - { - "sim":51.0, - "partner":"4cdm" - }, - { - "sim":51.0, - "partner":"7vj0" - }, - { - "sim":51.0, - "partner":"7yec" + "partner":"4cdn" }, { "sim":51.0, - "partner":"4cdn" + "partner":"7vj2" }, { "sim":51.0, - "partner":"7vj1" + "partner":"7yd7" }, { "sim":51.0, @@ -852294,11 +855453,11 @@ }, { "sim":51.0, - "partner":"7vj2" + "partner":"8kcm" }, { "sim":51.0, - "partner":"7yd7" + "partner":"7vj3" }, { "sim":51.0, @@ -852306,16 +855465,12 @@ }, { "sim":51.0, - "partner":"7vj3" + "partner":"7vj4" }, { "sim":51.0, "partner":"2xrz" }, - { - "sim":51.0, - "partner":"7vj4" - }, { "sim":51.0, "partner":"7vj5" @@ -852408,10 +855563,6 @@ "sim":51.0, "partner":"5zcw" }, - { - "sim":51.0, - "partner":"8kcm" - }, { "sim":51.0, "partner":"7yeb" @@ -852424,6 +855575,10 @@ "sim":51.0, "partner":"7yej" }, + { + "sim":51.0, + "partner":"7f8t" + }, { "sim":51.0, "partner":"7viw" @@ -852438,7 +855593,35 @@ }, { "sim":51.0, - "partner":"7jrl" + "partner":"7viy" + }, + { + "sim":51.0, + "partner":"7viz" + }, + { + "sim":51.0, + "partner":"7ycm" + }, + { + "sim":51.0, + "partner":"7yee" + }, + { + "sim":51.0, + "partner":"7vj0" + }, + { + "sim":51.0, + "partner":"7yec" + }, + { + "sim":51.0, + "partner":"4cdm" + }, + { + "sim":51.0, + "partner":"7vj1" }, { "sim":51.0, @@ -852452,6 +855635,10 @@ "sim":51.0, "partner":"5o8e" }, + { + "sim":51.0, + "partner":"7jrl" + }, { "sim":51.0, "partner":"3ki9" @@ -852472,6 +855659,14 @@ "sim":51.0, "partner":"5kky" }, + { + "sim":51.0, + "partner":"8oy9" + }, + { + "sim":51.0, + "partner":"8oy4" + }, { "sim":51.0, "partner":"8oya" @@ -852508,14 +855703,6 @@ "sim":51.0, "partner":"8oy3" }, - { - "sim":51.0, - "partner":"8oy9" - }, - { - "sim":51.0, - "partner":"8oy4" - }, { "sim":51.0, "partner":"5ccu" @@ -852582,15 +855769,15 @@ }, { "sim":51.0, - "partner":"5kdn" + "partner":"5kds" }, { "sim":51.0, - "partner":"5kds" + "partner":"5kdu" }, { "sim":51.0, - "partner":"5kdu" + "partner":"5kdn" }, { "sim":51.0, @@ -852654,11 +855841,11 @@ }, { "sim":51.0, - "partner":"2zxh" + "partner":"2zxi" }, { "sim":51.0, - "partner":"2zxi" + "partner":"2zxh" }, { "sim":51.0, @@ -852734,11 +855921,11 @@ }, { "sim":50.0, - "partner":"5cvo" + "partner":"6nyo" }, { "sim":50.0, - "partner":"6nyo" + "partner":"5cvo" }, { "sim":50.0, @@ -852794,11 +855981,11 @@ }, { "sim":50.0, - "partner":"4o1h" + "partner":"1j6y" }, { "sim":50.0, - "partner":"1j6y" + "partner":"4o1h" }, { "sim":50.0, @@ -852810,11 +855997,11 @@ }, { "sim":50.0, - "partner":"4a4y" + "partner":"6l8p" }, { "sim":50.0, - "partner":"6l8p" + "partner":"4a4y" }, { "sim":50.0, @@ -852838,43 +856025,39 @@ }, { "sim":50.0, - "partner":"5y0f" - }, - { - "sim":50.0, - "partner":"5y0g" + "partner":"4nns" }, { "sim":50.0, - "partner":"4nns" + "partner":"4nnt" }, { "sim":50.0, - "partner":"4nnt" + "partner":"6ljs" }, { "sim":50.0, - "partner":"5y12" + "partner":"6ljt" }, { "sim":50.0, - "partner":"6ljs" + "partner":"8wdx" }, { "sim":50.0, - "partner":"5d45" + "partner":"5y12" }, { "sim":50.0, - "partner":"5y13" + "partner":"6lju" }, { "sim":50.0, - "partner":"6ljt" + "partner":"5d45" }, { "sim":50.0, - "partner":"6lju" + "partner":"5y13" }, { "sim":50.0, @@ -852894,7 +856077,7 @@ }, { "sim":50.0, - "partner":"8wdx" + "partner":"8we3" }, { "sim":50.0, @@ -852914,11 +856097,15 @@ }, { "sim":50.0, - "partner":"8we3" + "partner":"5y0x" }, { "sim":50.0, - "partner":"5y0x" + "partner":"5y0f" + }, + { + "sim":50.0, + "partner":"5y0g" }, { "sim":50.0, @@ -852934,11 +856121,11 @@ }, { "sim":50.0, - "partner":"2ypj" + "partner":"6lag" }, { "sim":50.0, - "partner":"6lag" + "partner":"2ypj" }, { "sim":50.0, @@ -852948,10 +856135,6 @@ "sim":50.0, "partner":"6rcx" }, - { - "sim":50.0, - "partner":"4a41" - }, { "sim":50.0, "partner":"4a44" @@ -852966,19 +856149,19 @@ }, { "sim":50.0, - "partner":"3t8y" + "partner":"4a41" }, { "sim":50.0, - "partner":"6bws" + "partner":"3t8y" }, { "sim":50.0, - "partner":"6c0z" + "partner":"6bws" }, { "sim":50.0, - "partner":"2vbq" + "partner":"6c0z" }, { "sim":50.0, @@ -852994,7 +856177,7 @@ }, { "sim":50.0, - "partner":"1vb6" + "partner":"2vbq" }, { "sim":50.0, @@ -853004,6 +856187,10 @@ "sim":50.0, "partner":"1v9z" }, + { + "sim":50.0, + "partner":"1vb6" + }, { "sim":50.0, "partner":"8fxd" @@ -853042,27 +856229,27 @@ }, { "sim":50.0, - "partner":"7xtl" + "partner":"3u30" }, { "sim":50.0, - "partner":"3u30" + "partner":"4ip3" }, { "sim":50.0, - "partner":"4ip3" + "partner":"7f13" }, { "sim":50.0, - "partner":"8t48" + "partner":"7f14" }, { "sim":50.0, - "partner":"7f13" + "partner":"8t48" }, { "sim":50.0, - "partner":"7f14" + "partner":"7xtl" }, { "sim":50.0, @@ -853090,23 +856277,23 @@ }, { "sim":50.0, - "partner":"1x24" + "partner":"4gzd" }, { "sim":50.0, - "partner":"4gzc" + "partner":"1zcl" }, { "sim":50.0, - "partner":"4gzd" + "partner":"7ckv" }, { "sim":50.0, - "partner":"1zcl" + "partner":"1x24" }, { "sim":50.0, - "partner":"7ckv" + "partner":"4gzc" }, { "sim":50.0, @@ -853122,11 +856309,11 @@ }, { "sim":50.0, - "partner":"4nsq" + "partner":"4f07" }, { "sim":50.0, - "partner":"4f07" + "partner":"4nsq" }, { "sim":50.0, @@ -853150,15 +856337,15 @@ }, { "sim":50.0, - "partner":"3th5" + "partner":"4gzl" }, { "sim":50.0, - "partner":"4gzl" + "partner":"4gzm" }, { "sim":50.0, - "partner":"4gzm" + "partner":"3th5" }, { "sim":50.0, @@ -853186,11 +856373,11 @@ }, { "sim":50.0, - "partner":"6nko" + "partner":"3sbc" }, { "sim":50.0, - "partner":"3sbc" + "partner":"6nko" }, { "sim":50.0, @@ -853260,10 +856447,6 @@ "sim":50.0, "partner":"3uwk" }, - { - "sim":50.0, - "partner":"7f8s" - }, { "sim":50.0, "partner":"4lui" @@ -853278,23 +856461,23 @@ }, { "sim":50.0, - "partner":"3coj" + "partner":"7f8s" }, { "sim":50.0, - "partner":"2qhs" + "partner":"3coj" }, { "sim":50.0, - "partner":"7o2t" + "partner":"2qhs" }, { "sim":50.0, - "partner":"7o2u" + "partner":"6z17" }, { "sim":50.0, - "partner":"6z17" + "partner":"7o2u" }, { "sim":50.0, @@ -853314,31 +856497,31 @@ }, { "sim":50.0, - "partner":"3rpu" + "partner":"7o2t" }, { "sim":50.0, - "partner":"4iqz" + "partner":"3rpu" }, { "sim":50.0, - "partner":"4bmx" + "partner":"4iqz" }, { "sim":50.0, - "partner":"4bmy" + "partner":"4bmz" }, { "sim":50.0, - "partner":"4bmz" + "partner":"4bn0" }, { "sim":50.0, - "partner":"4bn0" + "partner":"4bmx" }, { "sim":50.0, - "partner":"4da6" + "partner":"4bmy" }, { "sim":50.0, @@ -853392,6 +856575,10 @@ "sim":50.0, "partner":"4d8v" }, + { + "sim":50.0, + "partner":"4da6" + }, { "sim":50.0, "partner":"5t38" @@ -853424,14 +856611,6 @@ "sim":50.0, "partner":"6gap" }, - { - "sim":50.0, - "partner":"5tgs" - }, - { - "sim":50.0, - "partner":"8w8h" - }, { "sim":50.0, "partner":"2ouk" @@ -853446,23 +856625,23 @@ }, { "sim":50.0, - "partner":"2olj" + "partner":"8w8h" }, { "sim":50.0, - "partner":"5th5" + "partner":"2olj" }, { "sim":50.0, - "partner":"2olk" + "partner":"5th5" }, { "sim":50.0, - "partner":"8wbk" + "partner":"2olk" }, { "sim":50.0, - "partner":"8wbl" + "partner":"5tgs" }, { "sim":50.0, @@ -853486,7 +856665,11 @@ }, { "sim":50.0, - "partner":"4ke6" + "partner":"8wbk" + }, + { + "sim":50.0, + "partner":"8wbl" }, { "sim":50.0, @@ -853510,15 +856693,19 @@ }, { "sim":50.0, - "partner":"8j7c" + "partner":"4ke6" }, { "sim":50.0, - "partner":"8jbp" + "partner":"4gnj" }, { "sim":50.0, - "partner":"4gnj" + "partner":"8j7c" + }, + { + "sim":50.0, + "partner":"8jbp" }, { "sim":50.0, @@ -853542,11 +856729,11 @@ }, { "sim":50.0, - "partner":"6hxo" + "partner":"6hxn" }, { "sim":50.0, - "partner":"6hxn" + "partner":"6hxo" }, { "sim":50.0, @@ -853554,11 +856741,11 @@ }, { "sim":50.0, - "partner":"8spk" + "partner":"6ypa" }, { "sim":50.0, - "partner":"6ypa" + "partner":"8spk" }, { "sim":50.0, @@ -853566,31 +856753,31 @@ }, { "sim":50.0, - "partner":"3quo" + "partner":"3qur" }, { "sim":50.0, - "partner":"3qvf" + "partner":"3qvh" }, { "sim":50.0, - "partner":"3qur" + "partner":"3d40" }, { "sim":50.0, - "partner":"3qvh" + "partner":"3d41" }, { "sim":50.0, - "partner":"3d40" + "partner":"3qun" }, { "sim":50.0, - "partner":"3d41" + "partner":"3quo" }, { "sim":50.0, - "partner":"3qun" + "partner":"3qvf" }, { "sim":50.0, @@ -853606,19 +856793,19 @@ }, { "sim":50.0, - "partner":"7a61" + "partner":"8rwq" }, { "sim":50.0, - "partner":"5uj3" + "partner":"6mnp" }, { "sim":50.0, - "partner":"5uj4" + "partner":"8rwr" }, { "sim":50.0, - "partner":"6mnp" + "partner":"5uj3" }, { "sim":50.0, @@ -853626,7 +856813,11 @@ }, { "sim":50.0, - "partner":"5ul8" + "partner":"8rws" + }, + { + "sim":50.0, + "partner":"5uj4" }, { "sim":50.0, @@ -853640,6 +856831,10 @@ "sim":50.0, "partner":"6d17" }, + { + "sim":50.0, + "partner":"5ul8" + }, { "sim":50.0, "partner":"6d18" @@ -853680,10 +856875,6 @@ "sim":50.0, "partner":"6z24" }, - { - "sim":50.0, - "partner":"1zct" - }, { "sim":50.0, "partner":"6qwd" @@ -853698,7 +856889,7 @@ }, { "sim":50.0, - "partner":"8rwq" + "partner":"1zct" }, { "sim":50.0, @@ -853708,13 +856899,17 @@ "sim":50.0, "partner":"6v1j" }, + { + "sim":50.0, + "partner":"8aki" + }, { "sim":50.0, "partner":"6v7i" }, { "sim":50.0, - "partner":"8aki" + "partner":"8akj" }, { "sim":50.0, @@ -853726,7 +856921,7 @@ }, { "sim":50.0, - "partner":"8akj" + "partner":"8akk" }, { "sim":50.0, @@ -853734,15 +856929,23 @@ }, { "sim":50.0, - "partner":"8akk" + "partner":"8akl" }, { "sim":50.0, - "partner":"8akl" + "partner":"8akm" }, { "sim":50.0, - "partner":"8akm" + "partner":"7a61" + }, + { + "sim":50.0, + "partner":"8rwo" + }, + { + "sim":50.0, + "partner":"8rwp" }, { "sim":50.0, @@ -853820,10 +857023,6 @@ "sim":50.0, "partner":"8tms" }, - { - "sim":50.0, - "partner":"3s3h" - }, { "sim":50.0, "partner":"3s3k" @@ -853836,6 +857035,10 @@ "sim":50.0, "partner":"3s3f" }, + { + "sim":50.0, + "partner":"3s3h" + }, { "sim":50.0, "partner":"6oxh" @@ -853862,11 +857065,11 @@ }, { "sim":50.0, - "partner":"5okt" + "partner":"7nzy" }, { "sim":50.0, - "partner":"7nzy" + "partner":"5okt" }, { "sim":50.0, @@ -853882,11 +857085,11 @@ }, { "sim":50.0, - "partner":"1l9x" + "partner":"3na8" }, { "sim":50.0, - "partner":"3na8" + "partner":"1l9x" }, { "sim":50.0, @@ -853914,11 +857117,11 @@ }, { "sim":50.0, - "partner":"4hac" + "partner":"7p5p" }, { "sim":50.0, - "partner":"7p5p" + "partner":"4hac" }, { "sim":50.0, @@ -853972,14 +857175,6 @@ "sim":50.0, "partner":"5zl1" }, - { - "sim":50.0, - "partner":"7v52" - }, - { - "sim":50.0, - "partner":"7v54" - }, { "sim":50.0, "partner":"7v56" @@ -854006,15 +857201,15 @@ }, { "sim":50.0, - "partner":"6lcn" + "partner":"7v52" }, { "sim":50.0, - "partner":"4w7v" + "partner":"7v54" }, { "sim":50.0, - "partner":"4w7w" + "partner":"6lcn" }, { "sim":50.0, @@ -854024,6 +857219,14 @@ "sim":50.0, "partner":"4w7u" }, + { + "sim":50.0, + "partner":"4w7v" + }, + { + "sim":50.0, + "partner":"4w7w" + }, { "sim":50.0, "partner":"4iql" @@ -854060,10 +857263,6 @@ "sim":50.0, "partner":"5hpc" }, - { - "sim":50.0, - "partner":"2pt0" - }, { "sim":50.0, "partner":"3d1o" @@ -854084,6 +857283,10 @@ "sim":50.0, "partner":"2psz" }, + { + "sim":50.0, + "partner":"2pt0" + }, { "sim":50.0, "partner":"7svq" @@ -854158,11 +857361,11 @@ }, { "sim":50.0, - "partner":"2x6t" + "partner":"2x86" }, { "sim":50.0, - "partner":"2x86" + "partner":"2x6t" }, { "sim":50.0, @@ -854176,10 +857379,6 @@ "sim":50.0, "partner":"7utf" }, - { - "sim":50.0, - "partner":"8tne" - }, { "sim":50.0, "partner":"6ems" @@ -854198,7 +857397,7 @@ }, { "sim":50.0, - "partner":"4m1i" + "partner":"8tne" }, { "sim":50.0, @@ -854222,12 +857421,16 @@ }, { "sim":50.0, - "partner":"6eow" + "partner":"4m1i" }, { "sim":50.0, "partner":"8s5f" }, + { + "sim":50.0, + "partner":"6eow" + }, { "sim":50.0, "partner":"5xnc" @@ -854256,21 +857459,17 @@ "sim":50.0, "partner":"6eug" }, - { - "sim":50.0, - "partner":"4rl1" - }, { "sim":50.0, "partner":"6euh" }, { "sim":50.0, - "partner":"6eui" + "partner":"4rl1" }, { "sim":50.0, - "partner":"3c1y" + "partner":"6eui" }, { "sim":50.0, @@ -854304,6 +857503,10 @@ "sim":50.0, "partner":"8h61" }, + { + "sim":50.0, + "partner":"3c1y" + }, { "sim":50.0, "partner":"6rfp" @@ -854320,10 +857523,6 @@ "sim":50.0, "partner":"4rzt" }, - { - "sim":50.0, - "partner":"3pz9" - }, { "sim":50.0, "partner":"3pzg" @@ -854350,7 +857549,7 @@ }, { "sim":50.0, - "partner":"6ojx" + "partner":"3pz9" }, { "sim":50.0, @@ -854386,11 +857585,11 @@ }, { "sim":50.0, - "partner":"5kvs" + "partner":"6olm" }, { "sim":50.0, - "partner":"6olm" + "partner":"5kvs" }, { "sim":50.0, @@ -854398,7 +857597,7 @@ }, { "sim":50.0, - "partner":"7azd" + "partner":"6ojx" }, { "sim":50.0, @@ -854430,16 +857629,20 @@ }, { "sim":50.0, - "partner":"5x06" + "partner":"7azg" }, { "sim":50.0, - "partner":"7azg" + "partner":"5x06" }, { "sim":50.0, "partner":"7azc" }, + { + "sim":50.0, + "partner":"7azd" + }, { "sim":50.0, "partner":"8sm8" @@ -854450,31 +857653,31 @@ }, { "sim":50.0, - "partner":"6zgp" + "partner":"6y9d" }, { "sim":50.0, - "partner":"6y8j" + "partner":"6zgp" }, { "sim":50.0, - "partner":"6y9c" + "partner":"2qap" }, { "sim":50.0, - "partner":"6y9d" + "partner":"6y8s" }, { "sim":50.0, - "partner":"2qap" + "partner":"2qdg" }, { "sim":50.0, - "partner":"6y8s" + "partner":"6y8j" }, { "sim":50.0, - "partner":"2qdg" + "partner":"6y9c" }, { "sim":50.0, @@ -854556,10 +857759,6 @@ "sim":50.0, "partner":"3mmr" }, - { - "sim":50.0, - "partner":"2gqn" - }, { "sim":50.0, "partner":"3i65" @@ -854584,6 +857783,10 @@ "sim":50.0, "partner":"2fq6" }, + { + "sim":50.0, + "partner":"2gqn" + }, { "sim":50.0, "partner":"1jk0" @@ -854608,10 +857811,6 @@ "sim":50.0, "partner":"4pk6" }, - { - "sim":50.0, - "partner":"3pln" - }, { "sim":50.0, "partner":"3phl" @@ -854624,6 +857823,10 @@ "sim":50.0, "partner":"3pjg" }, + { + "sim":50.0, + "partner":"3pln" + }, { "sim":50.0, "partner":"4zyj" @@ -854660,10 +857863,6 @@ "sim":50.0, "partner":"2gp6" }, - { - "sim":50.0, - "partner":"4q6q" - }, { "sim":50.0, "partner":"4q6m" @@ -854680,6 +857879,10 @@ "sim":50.0, "partner":"4q6p" }, + { + "sim":50.0, + "partner":"4q6q" + }, { "sim":50.0, "partner":"4kp1" @@ -854690,11 +857893,11 @@ }, { "sim":50.0, - "partner":"3aov" + "partner":"8eul" }, { "sim":50.0, - "partner":"8eul" + "partner":"3aov" }, { "sim":50.0, @@ -854838,83 +858041,83 @@ }, { "sim":50.0, - "partner":"8gf0" + "partner":"7lam" }, { "sim":50.0, - "partner":"8gfp" + "partner":"8gfb" }, { "sim":50.0, - "partner":"8gf1" + "partner":"8gfc" }, { "sim":50.0, - "partner":"8gfq" + "partner":"8gfd" }, { "sim":50.0, - "partner":"8gfs" + "partner":"8gfe" }, { "sim":50.0, - "partner":"7lam" + "partner":"7laq" }, { "sim":50.0, - "partner":"7laq" + "partner":"8gff" }, { "sim":50.0, - "partner":"8gfb" + "partner":"8gfg" }, { "sim":50.0, - "partner":"8gfc" + "partner":"6l4o" }, { "sim":50.0, - "partner":"8gfd" + "partner":"8gfh" }, { "sim":50.0, - "partner":"6l4o" + "partner":"8gfi" }, { "sim":50.0, - "partner":"8gfe" + "partner":"8gfj" }, { "sim":50.0, - "partner":"8gff" + "partner":"8gfl" }, { "sim":50.0, - "partner":"8gfg" + "partner":"8gfm" }, { "sim":50.0, - "partner":"8gfh" + "partner":"8gez" }, { "sim":50.0, - "partner":"8gfi" + "partner":"8gf0" }, { "sim":50.0, - "partner":"8gfj" + "partner":"8gfp" }, { "sim":50.0, - "partner":"8gfl" + "partner":"8gf1" }, { "sim":50.0, - "partner":"8gfm" + "partner":"8gfq" }, { "sim":50.0, - "partner":"8gez" + "partner":"8gfs" }, { "sim":50.0, @@ -854940,10 +858143,6 @@ "sim":50.0, "partner":"5uqn" }, - { - "sim":50.0, - "partner":"5wm2" - }, { "sim":50.0, "partner":"5wm3" @@ -854964,6 +858163,10 @@ "sim":50.0, "partner":"5wm7" }, + { + "sim":50.0, + "partner":"5wm2" + }, { "sim":50.0, "partner":"5tkv" @@ -854978,15 +858181,15 @@ }, { "sim":50.0, - "partner":"5tsh" + "partner":"6olj" }, { "sim":50.0, - "partner":"6olj" + "partner":"5tsg" }, { "sim":50.0, - "partner":"5tsg" + "partner":"5tsh" }, { "sim":50.0, @@ -855012,21 +858215,17 @@ "sim":50.0, "partner":"3zw8" }, - { - "sim":50.0, - "partner":"3zw9" - }, { "sim":50.0, "partner":"6z5f" }, { "sim":50.0, - "partner":"3zwa" + "partner":"3zw9" }, { "sim":50.0, - "partner":"3zwb" + "partner":"3zwa" }, { "sim":50.0, @@ -855038,12 +858237,16 @@ }, { "sim":50.0, - "partner":"3zwc" + "partner":"3zwb" }, { "sim":50.0, "partner":"6zic" }, + { + "sim":50.0, + "partner":"3zwc" + }, { "sim":50.0, "partner":"5mgb" @@ -855070,15 +858273,15 @@ }, { "sim":50.0, - "partner":"8wxf" + "partner":"8wx0" }, { "sim":50.0, - "partner":"8wx0" + "partner":"8wwp" }, { "sim":50.0, - "partner":"8wwp" + "partner":"8wxf" }, { "sim":50.0, @@ -855094,35 +858297,35 @@ }, { "sim":50.0, - "partner":"3ahc" + "partner":"3ahf" }, { "sim":50.0, - "partner":"3ahd" + "partner":"3ahg" }, { "sim":50.0, - "partner":"3ahe" + "partner":"3ahh" }, { "sim":50.0, - "partner":"3ahf" + "partner":"3ahi" }, { "sim":50.0, - "partner":"3ahg" + "partner":"3ahj" }, { "sim":50.0, - "partner":"3ahh" + "partner":"3ahc" }, { "sim":50.0, - "partner":"3ahi" + "partner":"3ahd" }, { "sim":50.0, - "partner":"3ahj" + "partner":"3ahe" }, { "sim":50.0, @@ -855130,19 +858333,15 @@ }, { "sim":50.0, - "partner":"6tsh" - }, - { - "sim":50.0, - "partner":"6tte" + "partner":"6tsk" }, { "sim":50.0, - "partner":"6tsk" + "partner":"6tsh" }, { "sim":50.0, - "partner":"6yt0" + "partner":"6tte" }, { "sim":50.0, @@ -855159,6 +858358,10 @@ { "sim":50.0, "partner":"6ytj" + }, + { + "sim":50.0, + "partner":"6yt0" } ], "struct_thr_sim_designed":[ @@ -855220,10 +858423,10 @@ ], "subtitle":"Human p53 dna-binding domain bound to darpin c10", "tags":[ + "designed ankyrin repeat proteins (darpins)", "dna binding protein", "p53 reactivation in hpv-infected cells", - "p53 tumor suppressor", - "designed ankyrin repeat proteins (darpins)" + "p53 tumor suppressor" ], "keywords":[ "description", @@ -855260,11 +858463,11 @@ "seq_thr_sim_designed":[ { "sim":224.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":224.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":219.0, @@ -855292,11 +858495,11 @@ }, { "sim":202.0, - "partner":"7zyu" + "partner":"7z7c" }, { "sim":202.0, - "partner":"7z7c" + "partner":"7zyu" }, { "sim":201.0, @@ -855334,6 +858537,10 @@ "sim":199.0, "partner":"8ak1" }, + { + "sim":198.0, + "partner":"9glq" + }, { "sim":198.0, "partner":"7z72" @@ -855344,19 +858551,19 @@ }, { "sim":197.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":197.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":197.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":197.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":197.0, @@ -855364,35 +858571,35 @@ }, { "sim":197.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":197.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":197.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":197.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":197.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":197.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":197.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":197.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":196.0, @@ -855440,11 +858647,11 @@ }, { "sim":189.0, - "partner":"4j8y" + "partner":"5knh" }, { "sim":189.0, - "partner":"5knh" + "partner":"4j8y" }, { "sim":188.0, @@ -855512,7 +858719,7 @@ }, { "sim":180.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":180.0, @@ -855520,7 +858727,7 @@ }, { "sim":180.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":180.0, @@ -855540,11 +858747,11 @@ }, { "sim":177.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":177.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":177.0, @@ -855600,11 +858807,11 @@ }, { "sim":138.0, - "partner":"4gpm" + "partner":"4hb5" }, { "sim":138.0, - "partner":"4hb5" + "partner":"4gpm" }, { "sim":136.0, @@ -855628,10 +858835,6 @@ } ], "seq_thr_sim_natural":[ - { - "sim":225.0, - "partner":"7pd8" - }, { "sim":225.0, "partner":"7pdd" @@ -855644,6 +858847,10 @@ "sim":225.0, "partner":"7pdh" }, + { + "sim":225.0, + "partner":"7pd8" + }, { "sim":211.0, "partner":"6fp7" @@ -855666,11 +858873,11 @@ }, { "sim":209.0, - "partner":"2y0b" + "partner":"8ipf" }, { "sim":209.0, - "partner":"8ipf" + "partner":"2y0b" }, { "sim":207.0, @@ -855690,11 +858897,11 @@ }, { "sim":205.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":205.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":205.0, @@ -855736,10 +858943,6 @@ "sim":202.0, "partner":"3zuv" }, - { - "sim":201.0, - "partner":"8tzb" - }, { "sim":201.0, "partner":"8tzc" @@ -855756,6 +858959,10 @@ "sim":201.0, "partner":"8tzh" }, + { + "sim":201.0, + "partner":"8tzb" + }, { "sim":200.0, "partner":"4hrm" @@ -855800,30 +859007,18 @@ "sim":197.0, "partner":"6bbn" }, - { - "sim":197.0, - "partner":"7yz0" - }, { "sim":197.0, "partner":"6mzf" }, { "sim":197.0, - "partner":"7yz1" - }, - { - "sim":197.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":197.0, "partner":"5nqt" }, - { - "sim":197.0, - "partner":"6mze" - }, { "sim":197.0, "partner":"7yz2" @@ -855834,11 +859029,11 @@ }, { "sim":197.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":197.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":197.0, @@ -855848,13 +859043,17 @@ "sim":197.0, "partner":"7yz5" }, + { + "sim":197.0, + "partner":"7yz6" + }, { "sim":197.0, "partner":"4lnu" }, { "sim":197.0, - "partner":"7yz6" + "partner":"6zwb" }, { "sim":197.0, @@ -855868,10 +859067,6 @@ "sim":197.0, "partner":"5nm5" }, - { - "sim":197.0, - "partner":"6zwb" - }, { "sim":197.0, "partner":"6zwc" @@ -855884,6 +859079,18 @@ "sim":197.0, "partner":"7yyz" }, + { + "sim":197.0, + "partner":"7yz0" + }, + { + "sim":197.0, + "partner":"7yz1" + }, + { + "sim":197.0, + "partner":"7z01" + }, { "sim":197.0, "partner":"6nht" @@ -855946,19 +859153,19 @@ }, { "sim":192.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":192.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":192.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":192.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":192.0, @@ -856092,45 +859299,25 @@ "sim":186.0, "partner":"5aq8" }, - { - "sim":185.0, - "partner":"5eno" - }, - { - "sim":185.0, - "partner":"6zob" - }, - { - "sim":185.0, - "partner":"6zo5" - }, { "sim":185.0, "partner":"4dx6" }, { "sim":185.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":185.0, "partner":"6zoc" }, - { - "sim":185.0, - "partner":"5enp" - }, - { - "sim":185.0, - "partner":"6sgs" - }, { "sim":185.0, "partner":"6zo6" }, { "sim":185.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":185.0, @@ -856138,7 +859325,7 @@ }, { "sim":185.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":185.0, @@ -856146,11 +859333,11 @@ }, { "sim":185.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":185.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":185.0, @@ -856160,6 +859347,10 @@ "sim":185.0, "partner":"6zoe" }, + { + "sim":185.0, + "partner":"5enq" + }, { "sim":185.0, "partner":"6q4p" @@ -856168,6 +859359,10 @@ "sim":185.0, "partner":"6sgt" }, + { + "sim":185.0, + "partner":"7b8s" + }, { "sim":185.0, "partner":"7ouk" @@ -856182,20 +859377,24 @@ }, { "sim":185.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":185.0, - "partner":"6zo8" + "partner":"6zof" }, { "sim":185.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":185.0, "partner":"5enr" }, + { + "sim":185.0, + "partner":"7oul" + }, { "sim":185.0, "partner":"1svx" @@ -856206,39 +859405,39 @@ }, { "sim":185.0, - "partner":"6sgu" + "partner":"7b8t" }, { "sim":185.0, - "partner":"7oul" + "partner":"6zo9" }, { "sim":185.0, - "partner":"5nc5" + "partner":"6zog" }, { "sim":185.0, - "partner":"6zo9" + "partner":"5nc5" }, { "sim":185.0, - "partner":"6zog" + "partner":"7oum" }, { "sim":185.0, - "partner":"7b8t" + "partner":"5ens" }, { "sim":185.0, - "partner":"5ens" + "partner":"5en5" }, { "sim":185.0, - "partner":"7oum" + "partner":"6zoa" }, { "sim":185.0, - "partner":"5en5" + "partner":"6zoh" }, { "sim":185.0, @@ -856246,11 +859445,11 @@ }, { "sim":185.0, - "partner":"6zoa" + "partner":"6d65" }, { "sim":185.0, - "partner":"6zoh" + "partner":"6sgr" }, { "sim":185.0, @@ -856266,15 +859465,23 @@ }, { "sim":185.0, - "partner":"6d65" + "partner":"6zob" }, { "sim":185.0, - "partner":"6sgr" + "partner":"4dx5" }, { "sim":185.0, - "partner":"4dx5" + "partner":"5eno" + }, + { + "sim":185.0, + "partner":"6zo5" + }, + { + "sim":185.0, + "partner":"6q4n" }, { "sim":185.0, @@ -856424,10 +859631,6 @@ "sim":172.0, "partner":"6mzg" }, - { - "sim":171.0, - "partner":"8g4f" - }, { "sim":171.0, "partner":"8g42" @@ -856445,13 +859648,17 @@ "partner":"8g3k" }, { - "sim":170.0, - "partner":"3q9n" + "sim":171.0, + "partner":"8g4f" }, { "sim":170.0, "partner":"3q9u" }, + { + "sim":170.0, + "partner":"3q9n" + }, { "sim":170.0, "partner":"5mbl" @@ -856470,11 +859677,11 @@ }, { "sim":164.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":164.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":164.0, @@ -856534,23 +859741,23 @@ }, { "sim":96.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":96.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":96.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":96.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":96.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":96.0, @@ -856558,11 +859765,11 @@ }, { "sim":96.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":96.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":96.0, @@ -856686,23 +859893,19 @@ }, { "sim":85.0, - "partner":"3aaa" - }, - { - "sim":85.0, - "partner":"7dsb" + "partner":"7df7" }, { "sim":85.0, - "partner":"7df7" + "partner":"7dsa" }, { "sim":85.0, - "partner":"7dsa" + "partner":"7dsb" }, { "sim":85.0, - "partner":"5vhj" + "partner":"3aaa" }, { "sim":85.0, @@ -856734,15 +859937,15 @@ }, { "sim":85.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":85.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":85.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":85.0, @@ -856752,6 +859955,10 @@ "sim":85.0, "partner":"7vxw" }, + { + "sim":85.0, + "partner":"1uoh" + }, { "sim":85.0, "partner":"7vy4" @@ -856762,11 +859969,11 @@ }, { "sim":85.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":85.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":85.0, @@ -856922,11 +860129,11 @@ }, { "sim":74.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":74.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":74.0, @@ -856950,16 +860157,24 @@ }, { "sim":73.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":73.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":73.0, "partner":"7roy" }, + { + "sim":73.0, + "partner":"8wqg" + }, + { + "sim":73.0, + "partner":"8wqe" + }, { "sim":73.0, "partner":"8wqh" @@ -856988,14 +860203,6 @@ "sim":73.0, "partner":"8wqd" }, - { - "sim":73.0, - "partner":"8wqg" - }, - { - "sim":73.0, - "partner":"8wqe" - }, { "sim":73.0, "partner":"8je1" @@ -857172,10 +860379,6 @@ "sim":64.0, "partner":"4oav" }, - { - "sim":64.0, - "partner":"6v9x" - }, { "sim":64.0, "partner":"6v9y" @@ -857188,6 +860391,10 @@ "sim":64.0, "partner":"6v9w" }, + { + "sim":64.0, + "partner":"6v9x" + }, { "sim":64.0, "partner":"7or0" @@ -857224,14 +860431,6 @@ "sim":63.0, "partner":"1wdy" }, - { - "sim":62.0, - "partner":"6m11" - }, - { - "sim":62.0, - "partner":"6m12" - }, { "sim":62.0, "partner":"6m13" @@ -857256,6 +860455,14 @@ "sim":62.0, "partner":"4o1p" }, + { + "sim":62.0, + "partner":"6m11" + }, + { + "sim":62.0, + "partner":"6m12" + }, { "sim":61.0, "partner":"6ghm" @@ -857324,10 +860531,6 @@ "sim":57.0, "partner":"5cer" }, - { - "sim":57.0, - "partner":"6o1p" - }, { "sim":57.0, "partner":"6b5v" @@ -857366,11 +860569,7 @@ }, { "sim":57.0, - "partner":"7t6m" - }, - { - "sim":57.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":57.0, @@ -857406,15 +860605,19 @@ }, { "sim":57.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":57.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":57.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":57.0, + "partner":"7t6k" }, { "sim":57.0, @@ -857422,7 +860625,7 @@ }, { "sim":57.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":57.0, @@ -857430,7 +860633,11 @@ }, { "sim":57.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":57.0, + "partner":"8ffn" }, { "sim":55.0, @@ -857448,10 +860655,6 @@ "sim":55.0, "partner":"5wo6" }, - { - "sim":55.0, - "partner":"5iwr" - }, { "sim":55.0, "partner":"5iwt" @@ -857504,6 +860707,10 @@ "sim":55.0, "partner":"5iwp" }, + { + "sim":55.0, + "partner":"5iwr" + }, { "sim":55.0, "partner":"5wo7" @@ -857530,6 +860737,10 @@ "sim":0.9653000236, "partner":"7z73" }, + { + "sim":0.9756000042, + "partner":"9glq" + }, { "sim":0.9609000087, "partner":"8ak1" @@ -857619,15 +860830,15 @@ ], "seq_max_sim_designed":{ "sim":224.0, - "partner":"7b4v" + "partner":"7b4u" }, "seq_max_sim_natural":{ "sim":225.0, - "partner":"7pd8" + "partner":"7pdd" }, "struct_max_sim_designed":{ - "sim":0.9653000236, - "partner":"7z73" + "sim":0.9756000042, + "partner":"9glq" }, "struct_max_sim_natural":{ "sim":0.9751999974, @@ -857675,6 +860886,10 @@ "forename":"M.", "surname":"Pacesa" }, + { + "forename":"M.", + "surname":"Elia" + }, { "forename":"P.", "surname":"Gainza" @@ -857684,13 +860899,25 @@ "surname":"Elizarova" }, { - "forename":"R.", + "forename":"R.M.", "surname":"Neeser" }, + { + "forename":"P.W.", + "surname":"Lee" + }, { "forename":"L.", "surname":"Reymond" }, + { + "forename":"Y.", + "surname":"Miao" + }, + { + "forename":"L.", + "surname":"Scheller" + }, { "forename":"S.", "surname":"Georgeon" @@ -857699,6 +860926,18 @@ "forename":"J.", "surname":"Schmidt" }, + { + "forename":"P.", + "surname":"Schwaller" + }, + { + "forename":"S.J.", + "surname":"Maerkl" + }, + { + "forename":"M.", + "surname":"Bronstein" + }, { "forename":"B.E.", "surname":"Correia" @@ -857713,30 +860952,118 @@ ], "subtitle":"Crystal structure of actinonin-bound pdf1 and the computationally designed dbact553_1 protein binder", "tags":[ - "binder", - "computational", + "de novo", "switch", + "deformylase", "de novo protein", - "actinonin", - "de novo", "cid", - "deformylase" + "actinonin", + "computational", + "binder" ], "keywords":[ - "description", - "found" + "molecular", + "recognition", + "fingerprints", + "learning", + "structural", + "complexes", + "regulation", + "three", + "new", + "generalizability", + "strategy", + "therapies", + "drive", + "protein", + "representations", + "accurate", + "cells", + "systems", + "anticipate", + "trained", + "recent", + "induced", + "leveraged", + "10", + "deep", + "geometric", + "learned", + "conditioned", + "remarkably", + "engineered", + "however", + "mechanistic", + "assessed", + "experimentally", + "biological", + "surfaces", + "approach", + "proteins", + "develop", + "characterization", + "small", + "higher", + "pathways", + "computational", + "tools", + "1", + "emerged", + "task", + "surface", + "advances", + "design", + "challenging", + "living", + "binders", + "field", + "processes", + "potential", + "assembly", + "neosurfaces", + "chemically", + "validated", + "applied", + "demonstrated", + "repertoire", + "levels", + "expand", + "present", + "could", + "designed", + "events", + "specificities", + "mutational", + "providing", + "approaches", + "previously", + "based", + "synthetic", + "demonstration", + "powerful", + "arising", + "target", + "interactions", + "molecules", + "remained", + "innovative", + "sensing", + "high", + "uncommon", + "despite", + "affinities" ], "release_date":"2024-10-30", - "publication":"To be published", + "publication":"\"Targeting protein-ligand neosurfaces with a generalizable deep learning tool\", Nature", "publication_ref":{ - "DOI":"", - "PubMed":"", - "CSD":"", - "ISSN":"", - "ASTM":"" + "DOI":"10.1038\/s41586-024-08435-4", + "PubMed":"39814890", + "CSD":"0006", + "ISSN":"1476-4687", + "ASTM":"NATUAS" }, - "publication_country":"", - "abstract":"No description found.", + "publication_country":"UK", + "abstract":"Molecular recognition events between proteins drive biological processes in living systems 1 . However, higher levels of mechanistic regulation have emerged, in which protein-protein interactions are conditioned to small molecules 2-5 . Despite recent advances, computational tools for the design of new chemically induced protein interactions have remained a challenging task for the field 6,7 . Here we present a computational strategy for the design of proteins that target neosurfaces, that is, surfaces arising from protein-ligand complexes. To develop this strategy, we leveraged a geometric deep learning approach based on learned molecular surface representations 8,9 and experimentally validated binders against three drug-bound protein complexes: Bcl2-venetoclax, DB3-progesterone and PDF1-actinonin. All binders demonstrated high affinities and accurate specificities, as assessed by mutational and structural characterization. Remarkably, surface fingerprints previously trained only on proteins could be applied to neosurfaces induced by interactions with small molecules, providing a powerful demonstration of generalizability that is uncommon in other deep learning approaches. We anticipate that such designed chemically induced protein interactions will have the potential to expand the sensing repertoire and the assembly of new synthetic pathways in engineered cells for innovative drug-controlled cell-based therapies 10 .", "crystal_structure":{ "length_a":"49.440", "length_b":"75.010", @@ -857860,80 +861187,80 @@ "p400" ], "keywords":[ - "enabling", - "accuracy", - "performance", - "scope", - "without", - "100", - "density", - "amino", - "proteins", - "multiple", - "approach", - "hallucination", - "report", - "de", - "novo", - "1000", - "also", - "designability", + "designed", + "form", + "heterodimers", + "need", + "offers", + "scalability", + "design", "characterized", - "attractive", "problems", - "sizes", "efficient", - "optimization", - "acids", - "designed", - "method", - "advanced", - "different", + "space", + "learning", + "backbones", + "methods", + "structures", + "de", + "hallucination", "used", + "multiple", "approaches", - "functions", - "pipelines", - "scales", - "broad", - "relaxed", - "two", - "methods", + "enabling", + "field", "experimentally", - "crystal", - "validated", - "heterodimers", - "generative", + "different", + "respect", + "scales", + "three", "application", - "set", - "retraining", - "increasingly", - "design", - "produced", - "applicability", - "structures", - "protein", - "microscopy", + "without", + "1000", "synthetic", + "sizes", + "report", + "retraining", + "machine", + "pipeline", + "also", + "functions", + "relaxed", "interactions", - "offers", - "respect", + "protein", + "maps", + "optimization", + "performance", + "designability", + "amino", + "approach", "validate", - "space", + "proteins", + "comprising", "across", - "dominating", - "three", + "accuracy", + "broad", + "produced", + "microscopy", + "validated", + "novo", "sequence", - "maps", - "scalability", - "form", - "comprising", - "backbones", - "learning", - "field", + "applicability", + "scope", + "acids", + "increasingly", + "pipelines", + "two", + "generative", + "density", + "crystal", + "attractive", "ml", - "pipeline", - "need", - "machine" + "dominating", + "100", + "method", + "set", + "advanced" ], "release_date":"2024-10-16", "publication":"\"Scalable protein design using optimization in a relaxed sequence space\", Science, 386, 439-445", @@ -858026,54 +861353,54 @@ "subtitle":"Apo structure of computationally designed homotrimer tet4", "tags":[ "metalloprotein", - "computational design", - "de novo protein" + "de novo protein", + "computational design" ], "keywords":[ - "accuracy", - "parent", - "demonstrate", - "architectures", - "predefined", - "overall", "construction", + "geometries", + "form", "surrounding", - "coordination", - "respectively", - "assemblies", - "approach", - "report", - "although", + "terms", + "design", "metal", + "histidine", + "targeted", + "tris", + "respectively", + "around", + "environment", + "overall", "\u00e5", - "reactivities", - "method", - "constructed", - "geometries", + "oligomeric", + "tp1", + "predefined", "apply", - "targeted", - "two", - "terms", + "report", + "tet4", + "block", + "new", "homotrimeric", - "design", - "centers", + "although", "protein", - "tetrahedral", - "tris", "illustrating", - "tet4", - "block", - "environment", + "architectures", + "tetrahedral", + "approach", + "reactivities", + "constructed", + "accuracy", + "coordination", + "centers", + "demonstrate", + "building", "distinct", - "computational", - "histidine", + "two", + "parent", + "assemblies", "versatility", - "form", - "oligomeric", - "tp1", - "building", - "around", - "new" + "method", + "computational" ], "release_date":"2023-07-05", "publication":"\"Atomically Accurate Design of Metalloproteins with Predefined Coordination Geometries\", J.Am.Chem.Soc., 145, 14208-14214", @@ -858110,11 +861437,11 @@ }, { "sim":143.0, - "partner":"8sjh" + "partner":"8sji" }, { "sim":143.0, - "partner":"8sji" + "partner":"8sjh" } ], "seq_thr_sim_natural":[ @@ -858156,15 +861483,15 @@ }, { "sim":124.0, - "partner":"7xta" + "partner":"7xt8" }, { "sim":124.0, - "partner":"7xt8" + "partner":"7xt9" }, { "sim":124.0, - "partner":"7xt9" + "partner":"7xta" }, { "sim":124.0, @@ -858220,15 +861547,15 @@ }, { "sim":123.0, - "partner":"8irt" + "partner":"7cmu" }, { "sim":123.0, - "partner":"7cmu" + "partner":"7cmv" }, { "sim":123.0, - "partner":"7cmv" + "partner":"8irt" }, { "sim":123.0, @@ -858238,10 +861565,6 @@ "sim":123.0, "partner":"7w57" }, - { - "sim":119.0, - "partner":"7wvv" - }, { "sim":119.0, "partner":"7wvw" @@ -858256,51 +861579,55 @@ }, { "sim":119.0, - "partner":"7xy6" + "partner":"7wvv" }, { "sim":119.0, "partner":"7xy7" }, + { + "sim":119.0, + "partner":"7xy6" + }, { "sim":118.0, "partner":"6wz7" }, { "sim":117.0, - "partner":"6wz1" + "partner":"6wz2" }, { "sim":117.0, - "partner":"6x7e" + "partner":"6wz3" }, { "sim":117.0, - "partner":"6wz2" + "partner":"6wzc" }, { "sim":117.0, - "partner":"6wz3" + "partner":"6wz1" }, { "sim":117.0, - "partner":"6wzc" + "partner":"6x7e" }, { "sim":115.0, - "partner":"6wz0" + "partner":"6wyu" }, { "sim":115.0, - "partner":"6wyu" + "partner":"6wz0" }, { "sim":115.0, - "partner":"6rz5" + "partner":"6rz4" }, { "sim":115.0, - "partner":"6rz4" + "partner":"6rz5" }, { "sim":114.0, @@ -858324,15 +861651,15 @@ }, { "sim":113.0, - "partner":"7koo" + "partner":"7koq" }, { "sim":113.0, - "partner":"7koq" + "partner":"7kox" }, { "sim":113.0, - "partner":"7kox" + "partner":"7koo" }, { "sim":113.0, @@ -858344,19 +861671,19 @@ }, { "sim":112.0, - "partner":"6rz6" + "partner":"6rz9" }, { "sim":112.0, - "partner":"6rz7" + "partner":"6rz6" }, { "sim":112.0, - "partner":"6rz8" + "partner":"6rz7" }, { "sim":112.0, - "partner":"6rz9" + "partner":"6rz8" }, { "sim":112.0, @@ -858410,10 +861737,6 @@ "sim":112.0, "partner":"6pv8" }, - { - "sim":111.0, - "partner":"5yo4" - }, { "sim":111.0, "partner":"5awi" @@ -858438,6 +861761,10 @@ "sim":111.0, "partner":"1apc" }, + { + "sim":111.0, + "partner":"5yo4" + }, { "sim":111.0, "partner":"7sq0" @@ -858528,11 +861855,11 @@ }, { "sim":111.0, - "partner":"7ezc" + "partner":"8gne" }, { "sim":111.0, - "partner":"8gne" + "partner":"7ezc" }, { "sim":111.0, @@ -858556,75 +861883,75 @@ }, { "sim":111.0, - "partner":"5uvi" + "partner":"4eiy" }, { "sim":111.0, - "partner":"6mh8" + "partner":"6jzh" }, { "sim":111.0, - "partner":"4eiy" + "partner":"7rm5" }, { "sim":111.0, - "partner":"8fyn" + "partner":"5k2a" }, { "sim":111.0, - "partner":"6jzh" + "partner":"7pyr" }, { "sim":111.0, - "partner":"7rm5" + "partner":"5k2b" }, { "sim":111.0, - "partner":"5k2a" + "partner":"5k2c" }, { "sim":111.0, - "partner":"5k2b" + "partner":"5k2d" }, { "sim":111.0, - "partner":"7pyr" + "partner":"6lpj" }, { "sim":111.0, - "partner":"5k2c" + "partner":"6wqa" }, { "sim":111.0, - "partner":"5k2d" + "partner":"7px4" }, { "sim":111.0, - "partner":"7px4" + "partner":"6lpk" }, { "sim":111.0, - "partner":"6lpj" + "partner":"6lpl" }, { "sim":111.0, - "partner":"6wqa" + "partner":"5jtb" }, { "sim":111.0, - "partner":"6lpk" + "partner":"5vra" }, { "sim":111.0, - "partner":"5jtb" + "partner":"6mh8" }, { "sim":111.0, - "partner":"6lpl" + "partner":"5uvi" }, { "sim":111.0, - "partner":"5vra" + "partner":"8fyn" }, { "sim":111.0, @@ -858648,11 +861975,11 @@ }, { "sim":111.0, - "partner":"6pt3" + "partner":"6pt2" }, { "sim":111.0, - "partner":"6pt2" + "partner":"6pt3" }, { "sim":111.0, @@ -858704,11 +862031,15 @@ }, { "sim":111.0, - "partner":"7w0m" + "partner":"7w0n" }, { "sim":111.0, - "partner":"7w0n" + "partner":"8xqi" + }, + { + "sim":111.0, + "partner":"8xqj" }, { "sim":111.0, @@ -858728,12 +862059,32 @@ }, { "sim":111.0, - "partner":"6iiv" + "partner":"8xqe" + }, + { + "sim":111.0, + "partner":"8z7j" + }, + { + "sim":111.0, + "partner":"7w0m" + }, + { + "sim":111.0, + "partner":"8z74" + }, + { + "sim":111.0, + "partner":"8xqf" }, { "sim":111.0, "partner":"6iiu" }, + { + "sim":111.0, + "partner":"6iiv" + }, { "sim":111.0, "partner":"6usf" @@ -858778,10 +862129,6 @@ "sim":111.0, "partner":"5ndz" }, - { - "sim":111.0, - "partner":"7f4h" - }, { "sim":111.0, "partner":"7f4d" @@ -858794,6 +862141,10 @@ "sim":111.0, "partner":"7f4f" }, + { + "sim":111.0, + "partner":"7f4h" + }, { "sim":111.0, "partner":"8hj5" @@ -858814,29 +862165,17 @@ "sim":111.0, "partner":"8dep" }, - { - "sim":111.0, - "partner":"8hii" - }, - { - "sim":111.0, - "partner":"8hij" - }, { "sim":111.0, "partner":"8hik" }, { "sim":111.0, - "partner":"8dre" - }, - { - "sim":111.0, - "partner":"8f74" + "partner":"8hii" }, { "sim":111.0, - "partner":"8f7b" + "partner":"8hij" }, { "sim":111.0, @@ -858894,6 +862233,18 @@ "sim":111.0, "partner":"8drq" }, + { + "sim":111.0, + "partner":"8dre" + }, + { + "sim":111.0, + "partner":"8f74" + }, + { + "sim":111.0, + "partner":"8f7b" + }, { "sim":110.0, "partner":"6ot9" @@ -858982,30 +862333,10 @@ "sim":110.0, "partner":"7zl9" }, - { - "sim":110.0, - "partner":"5iu4" - }, - { - "sim":110.0, - "partner":"5mzp" - }, - { - "sim":110.0, - "partner":"5nlx" - }, - { - "sim":110.0, - "partner":"6gt3" - }, { "sim":110.0, "partner":"5iu7" }, - { - "sim":110.0, - "partner":"7aro" - }, { "sim":110.0, "partner":"5iu8" @@ -859036,11 +862367,11 @@ }, { "sim":110.0, - "partner":"5n2r" + "partner":"8cic" }, { "sim":110.0, - "partner":"8cic" + "partner":"5n2r" }, { "sim":110.0, @@ -859050,6 +862381,26 @@ "sim":110.0, "partner":"6s0q" }, + { + "sim":110.0, + "partner":"6gt3" + }, + { + "sim":110.0, + "partner":"5iu4" + }, + { + "sim":110.0, + "partner":"5mzp" + }, + { + "sim":110.0, + "partner":"5nlx" + }, + { + "sim":110.0, + "partner":"7aro" + }, { "sim":110.0, "partner":"5olv" @@ -859084,19 +862435,19 @@ }, { "sim":110.0, - "partner":"7y12" + "partner":"7y15" }, { "sim":110.0, - "partner":"7y13" + "partner":"7y12" }, { "sim":110.0, - "partner":"7y14" + "partner":"7y13" }, { "sim":110.0, - "partner":"7y15" + "partner":"7y14" }, { "sim":110.0, @@ -859110,6 +862461,46 @@ "sim":110.0, "partner":"8du3" }, + { + "sim":110.0, + "partner":"8rwc" + }, + { + "sim":110.0, + "partner":"8rwd" + }, + { + "sim":110.0, + "partner":"8rwe" + }, + { + "sim":110.0, + "partner":"8rwx" + }, + { + "sim":110.0, + "partner":"8rvw" + }, + { + "sim":110.0, + "partner":"8rw0" + }, + { + "sim":110.0, + "partner":"8rwh" + }, + { + "sim":110.0, + "partner":"8rwi" + }, + { + "sim":110.0, + "partner":"8rw4" + }, + { + "sim":110.0, + "partner":"8rw7" + }, { "sim":110.0, "partner":"5tud" @@ -859180,15 +862571,19 @@ }, { "sim":110.0, - "partner":"7zi0" + "partner":"5l7d" }, { "sim":110.0, - "partner":"5l7d" + "partner":"5l7i" }, { "sim":110.0, - "partner":"5l7i" + "partner":"7zi0" + }, + { + "sim":110.0, + "partner":"8zfz" }, { "sim":110.0, @@ -859208,15 +862603,15 @@ }, { "sim":109.0, - "partner":"5ym7" + "partner":"6cbv" }, { "sim":109.0, - "partner":"5yo6" + "partner":"5ym7" }, { "sim":109.0, - "partner":"6cbv" + "partner":"5yo6" }, { "sim":109.0, @@ -859248,11 +862643,11 @@ }, { "sim":109.0, - "partner":"8djk" + "partner":"8djm" }, { "sim":109.0, - "partner":"8djm" + "partner":"8djk" }, { "sim":109.0, @@ -859295,8 +862690,8 @@ "partner":"7eib" }, { - "sim":108.0, - "partner":"6dyb" + "sim":109.0, + "partner":"8x3k" }, { "sim":108.0, @@ -859306,17 +862701,13 @@ "sim":108.0, "partner":"3foo" }, - { - "sim":108.0, - "partner":"6dyc" - }, { "sim":108.0, "partner":"5l31" }, { "sim":108.0, - "partner":"6dyd" + "partner":"6dye" }, { "sim":108.0, @@ -859324,15 +862715,15 @@ }, { "sim":108.0, - "partner":"6dye" + "partner":"5l32" }, { "sim":108.0, - "partner":"5l32" + "partner":"6dhy" }, { "sim":108.0, - "partner":"6dhy" + "partner":"6wza" }, { "sim":108.0, @@ -859340,11 +862731,11 @@ }, { "sim":108.0, - "partner":"6wza" + "partner":"2qla" }, { "sim":108.0, - "partner":"2qla" + "partner":"6dhz" }, { "sim":108.0, @@ -859352,7 +862743,7 @@ }, { "sim":108.0, - "partner":"6dhz" + "partner":"6x8x" }, { "sim":108.0, @@ -859364,20 +862755,28 @@ }, { "sim":108.0, - "partner":"6x8x" + "partner":"1yyj" }, { "sim":108.0, - "partner":"1yyj" + "partner":"6dyb" }, { "sim":108.0, - "partner":"5yo3" + "partner":"6dyc" + }, + { + "sim":108.0, + "partner":"6dyd" }, { "sim":108.0, "partner":"5yo5" }, + { + "sim":108.0, + "partner":"5yo3" + }, { "sim":108.0, "partner":"7xki" @@ -859456,11 +862855,11 @@ }, { "sim":105.0, - "partner":"4jeb" + "partner":"6ot4" }, { "sim":105.0, - "partner":"6ot4" + "partner":"4jeb" }, { "sim":104.0, @@ -859468,15 +862867,15 @@ }, { "sim":104.0, - "partner":"3c62" + "partner":"7rwu" }, { "sim":104.0, - "partner":"3qvz" + "partner":"3c62" }, { "sim":104.0, - "partner":"7rwu" + "partner":"3qvz" }, { "sim":104.0, @@ -859484,11 +862883,11 @@ }, { "sim":104.0, - "partner":"3qw0" + "partner":"7su2" }, { "sim":104.0, - "partner":"7su2" + "partner":"3qw0" }, { "sim":104.0, @@ -859522,26 +862921,18 @@ "sim":104.0, "partner":"1lm3" }, - { - "sim":103.0, - "partner":"6ot7" - }, { "sim":103.0, "partner":"6ovh" }, { "sim":103.0, - "partner":"8drf" + "partner":"8drj" }, { "sim":103.0, "partner":"3c63" }, - { - "sim":103.0, - "partner":"8drj" - }, { "sim":103.0, "partner":"8drl" @@ -859555,8 +862946,12 @@ "partner":"8drd" }, { - "sim":102.0, - "partner":"6ot8" + "sim":103.0, + "partner":"6ot7" + }, + { + "sim":103.0, + "partner":"8drf" }, { "sim":102.0, @@ -859583,8 +862978,8 @@ "partner":"6dyl" }, { - "sim":101.0, - "partner":"5bu7" + "sim":102.0, + "partner":"6ot8" }, { "sim":101.0, @@ -859602,6 +862997,10 @@ "sim":101.0, "partner":"7lsn" }, + { + "sim":101.0, + "partner":"5bu7" + }, { "sim":100.0, "partner":"7dcl" @@ -859626,10 +863025,6 @@ "sim":99.0, "partner":"3hnj" }, - { - "sim":98.0, - "partner":"7lv1" - }, { "sim":98.0, "partner":"7lv4" @@ -859662,6 +863057,10 @@ "sim":98.0, "partner":"7lrv" }, + { + "sim":98.0, + "partner":"7lv1" + }, { "sim":97.0, "partner":"4u9e" @@ -859798,54 +863197,54 @@ "subtitle":"Zn-bound structure of computationally designed homotrimer tet4", "tags":[ "metalloprotein", - "computational design", - "de novo protein" + "de novo protein", + "computational design" ], "keywords":[ - "accuracy", - "parent", - "demonstrate", - "architectures", - "predefined", - "overall", "construction", + "geometries", + "form", "surrounding", - "coordination", - "respectively", - "assemblies", - "approach", - "report", - "although", + "terms", + "design", "metal", + "histidine", + "targeted", + "tris", + "respectively", + "around", + "environment", + "overall", "\u00e5", - "reactivities", - "method", - "constructed", - "geometries", + "oligomeric", + "tp1", + "predefined", "apply", - "targeted", - "two", - "terms", + "report", + "tet4", + "block", + "new", "homotrimeric", - "design", - "centers", + "although", "protein", - "tetrahedral", - "tris", "illustrating", - "tet4", - "block", - "environment", + "architectures", + "tetrahedral", + "approach", + "reactivities", + "constructed", + "accuracy", + "coordination", + "centers", + "demonstrate", + "building", "distinct", - "computational", - "histidine", + "two", + "parent", + "assemblies", "versatility", - "form", - "oligomeric", - "tp1", - "building", - "around", - "new" + "method", + "computational" ], "release_date":"2023-07-05", "publication":"\"Atomically Accurate Design of Metalloproteins with Predefined Coordination Geometries\", J.Am.Chem.Soc., 145, 14208-14214", @@ -859882,11 +863281,11 @@ }, { "sim":143.0, - "partner":"8sjh" + "partner":"8sji" }, { "sim":143.0, - "partner":"8sji" + "partner":"8sjh" } ], "seq_thr_sim_natural":[ @@ -859928,15 +863327,15 @@ }, { "sim":124.0, - "partner":"7xta" + "partner":"7xt8" }, { "sim":124.0, - "partner":"7xt8" + "partner":"7xt9" }, { "sim":124.0, - "partner":"7xt9" + "partner":"7xta" }, { "sim":124.0, @@ -859992,15 +863391,15 @@ }, { "sim":123.0, - "partner":"8irt" + "partner":"7cmu" }, { "sim":123.0, - "partner":"7cmu" + "partner":"7cmv" }, { "sim":123.0, - "partner":"7cmv" + "partner":"8irt" }, { "sim":123.0, @@ -860010,10 +863409,6 @@ "sim":123.0, "partner":"7w57" }, - { - "sim":119.0, - "partner":"7wvv" - }, { "sim":119.0, "partner":"7wvw" @@ -860028,51 +863423,55 @@ }, { "sim":119.0, - "partner":"7xy6" + "partner":"7wvv" }, { "sim":119.0, "partner":"7xy7" }, + { + "sim":119.0, + "partner":"7xy6" + }, { "sim":118.0, "partner":"6wz7" }, { "sim":117.0, - "partner":"6wz1" + "partner":"6wz2" }, { "sim":117.0, - "partner":"6x7e" + "partner":"6wz3" }, { "sim":117.0, - "partner":"6wz2" + "partner":"6wzc" }, { "sim":117.0, - "partner":"6wz3" + "partner":"6wz1" }, { "sim":117.0, - "partner":"6wzc" + "partner":"6x7e" }, { "sim":115.0, - "partner":"6wz0" + "partner":"6wyu" }, { "sim":115.0, - "partner":"6wyu" + "partner":"6wz0" }, { "sim":115.0, - "partner":"6rz5" + "partner":"6rz4" }, { "sim":115.0, - "partner":"6rz4" + "partner":"6rz5" }, { "sim":114.0, @@ -860096,15 +863495,15 @@ }, { "sim":113.0, - "partner":"7koo" + "partner":"7koq" }, { "sim":113.0, - "partner":"7koq" + "partner":"7kox" }, { "sim":113.0, - "partner":"7kox" + "partner":"7koo" }, { "sim":113.0, @@ -860116,19 +863515,19 @@ }, { "sim":112.0, - "partner":"6rz6" + "partner":"6rz9" }, { "sim":112.0, - "partner":"6rz7" + "partner":"6rz6" }, { "sim":112.0, - "partner":"6rz8" + "partner":"6rz7" }, { "sim":112.0, - "partner":"6rz9" + "partner":"6rz8" }, { "sim":112.0, @@ -860182,10 +863581,6 @@ "sim":112.0, "partner":"6pv8" }, - { - "sim":111.0, - "partner":"5yo4" - }, { "sim":111.0, "partner":"5awi" @@ -860210,6 +863605,10 @@ "sim":111.0, "partner":"1apc" }, + { + "sim":111.0, + "partner":"5yo4" + }, { "sim":111.0, "partner":"7sq0" @@ -860300,11 +863699,11 @@ }, { "sim":111.0, - "partner":"7ezc" + "partner":"8gne" }, { "sim":111.0, - "partner":"8gne" + "partner":"7ezc" }, { "sim":111.0, @@ -860328,75 +863727,75 @@ }, { "sim":111.0, - "partner":"5uvi" + "partner":"4eiy" }, { "sim":111.0, - "partner":"6mh8" + "partner":"6jzh" }, { "sim":111.0, - "partner":"4eiy" + "partner":"7rm5" }, { "sim":111.0, - "partner":"8fyn" + "partner":"5k2a" }, { "sim":111.0, - "partner":"6jzh" + "partner":"7pyr" }, { "sim":111.0, - "partner":"7rm5" + "partner":"5k2b" }, { "sim":111.0, - "partner":"5k2a" + "partner":"5k2c" }, { "sim":111.0, - "partner":"5k2b" + "partner":"5k2d" }, { "sim":111.0, - "partner":"7pyr" + "partner":"6lpj" }, { "sim":111.0, - "partner":"5k2c" + "partner":"6wqa" }, { "sim":111.0, - "partner":"5k2d" + "partner":"7px4" }, { "sim":111.0, - "partner":"7px4" + "partner":"6lpk" }, { "sim":111.0, - "partner":"6lpj" + "partner":"6lpl" }, { "sim":111.0, - "partner":"6wqa" + "partner":"5jtb" }, { "sim":111.0, - "partner":"6lpk" + "partner":"5vra" }, { "sim":111.0, - "partner":"5jtb" + "partner":"6mh8" }, { "sim":111.0, - "partner":"6lpl" + "partner":"5uvi" }, { "sim":111.0, - "partner":"5vra" + "partner":"8fyn" }, { "sim":111.0, @@ -860420,11 +863819,11 @@ }, { "sim":111.0, - "partner":"6pt3" + "partner":"6pt2" }, { "sim":111.0, - "partner":"6pt2" + "partner":"6pt3" }, { "sim":111.0, @@ -860476,11 +863875,15 @@ }, { "sim":111.0, - "partner":"7w0m" + "partner":"7w0n" }, { "sim":111.0, - "partner":"7w0n" + "partner":"8xqi" + }, + { + "sim":111.0, + "partner":"8xqj" }, { "sim":111.0, @@ -860500,12 +863903,32 @@ }, { "sim":111.0, - "partner":"6iiv" + "partner":"8xqe" + }, + { + "sim":111.0, + "partner":"8z7j" + }, + { + "sim":111.0, + "partner":"7w0m" + }, + { + "sim":111.0, + "partner":"8z74" + }, + { + "sim":111.0, + "partner":"8xqf" }, { "sim":111.0, "partner":"6iiu" }, + { + "sim":111.0, + "partner":"6iiv" + }, { "sim":111.0, "partner":"6usf" @@ -860550,10 +863973,6 @@ "sim":111.0, "partner":"5ndz" }, - { - "sim":111.0, - "partner":"7f4h" - }, { "sim":111.0, "partner":"7f4d" @@ -860566,6 +863985,10 @@ "sim":111.0, "partner":"7f4f" }, + { + "sim":111.0, + "partner":"7f4h" + }, { "sim":111.0, "partner":"8hj5" @@ -860586,29 +864009,17 @@ "sim":111.0, "partner":"8dep" }, - { - "sim":111.0, - "partner":"8hii" - }, - { - "sim":111.0, - "partner":"8hij" - }, { "sim":111.0, "partner":"8hik" }, { "sim":111.0, - "partner":"8dre" - }, - { - "sim":111.0, - "partner":"8f74" + "partner":"8hii" }, { "sim":111.0, - "partner":"8f7b" + "partner":"8hij" }, { "sim":111.0, @@ -860666,6 +864077,18 @@ "sim":111.0, "partner":"8drq" }, + { + "sim":111.0, + "partner":"8dre" + }, + { + "sim":111.0, + "partner":"8f74" + }, + { + "sim":111.0, + "partner":"8f7b" + }, { "sim":110.0, "partner":"6ot9" @@ -860756,71 +864179,71 @@ }, { "sim":110.0, - "partner":"5iu4" + "partner":"5iu7" }, { "sim":110.0, - "partner":"5mzp" + "partner":"5iu8" }, { "sim":110.0, - "partner":"5nlx" + "partner":"5iua" }, { "sim":110.0, - "partner":"6gt3" + "partner":"5iub" }, { "sim":110.0, - "partner":"5iu7" + "partner":"6s0l" }, { "sim":110.0, - "partner":"7aro" + "partner":"5nm2" }, { "sim":110.0, - "partner":"5iu8" + "partner":"6zdr" }, { "sim":110.0, - "partner":"5iua" + "partner":"5nm4" }, { "sim":110.0, - "partner":"5iub" + "partner":"8cic" }, { "sim":110.0, - "partner":"6s0l" + "partner":"5n2r" }, { "sim":110.0, - "partner":"5nm2" + "partner":"6zdv" }, { "sim":110.0, - "partner":"6zdr" + "partner":"6s0q" }, { "sim":110.0, - "partner":"5nm4" + "partner":"6gt3" }, { "sim":110.0, - "partner":"5n2r" + "partner":"5iu4" }, { "sim":110.0, - "partner":"8cic" + "partner":"5mzp" }, { "sim":110.0, - "partner":"6zdv" + "partner":"5nlx" }, { "sim":110.0, - "partner":"6s0q" + "partner":"7aro" }, { "sim":110.0, @@ -860856,19 +864279,19 @@ }, { "sim":110.0, - "partner":"7y12" + "partner":"7y15" }, { "sim":110.0, - "partner":"7y13" + "partner":"7y12" }, { "sim":110.0, - "partner":"7y14" + "partner":"7y13" }, { "sim":110.0, - "partner":"7y15" + "partner":"7y14" }, { "sim":110.0, @@ -860882,6 +864305,46 @@ "sim":110.0, "partner":"8du3" }, + { + "sim":110.0, + "partner":"8rwc" + }, + { + "sim":110.0, + "partner":"8rwd" + }, + { + "sim":110.0, + "partner":"8rwe" + }, + { + "sim":110.0, + "partner":"8rwx" + }, + { + "sim":110.0, + "partner":"8rvw" + }, + { + "sim":110.0, + "partner":"8rw0" + }, + { + "sim":110.0, + "partner":"8rwh" + }, + { + "sim":110.0, + "partner":"8rwi" + }, + { + "sim":110.0, + "partner":"8rw4" + }, + { + "sim":110.0, + "partner":"8rw7" + }, { "sim":110.0, "partner":"5tud" @@ -860952,15 +864415,19 @@ }, { "sim":110.0, - "partner":"7zi0" + "partner":"5l7d" }, { "sim":110.0, - "partner":"5l7d" + "partner":"5l7i" }, { "sim":110.0, - "partner":"5l7i" + "partner":"7zi0" + }, + { + "sim":110.0, + "partner":"8zfz" }, { "sim":110.0, @@ -860980,15 +864447,15 @@ }, { "sim":109.0, - "partner":"5ym7" + "partner":"6cbv" }, { "sim":109.0, - "partner":"5yo6" + "partner":"5ym7" }, { "sim":109.0, - "partner":"6cbv" + "partner":"5yo6" }, { "sim":109.0, @@ -861020,11 +864487,11 @@ }, { "sim":109.0, - "partner":"8djk" + "partner":"8djm" }, { "sim":109.0, - "partner":"8djm" + "partner":"8djk" }, { "sim":109.0, @@ -861067,8 +864534,8 @@ "partner":"7eib" }, { - "sim":108.0, - "partner":"6dyb" + "sim":109.0, + "partner":"8x3k" }, { "sim":108.0, @@ -861078,17 +864545,13 @@ "sim":108.0, "partner":"3foo" }, - { - "sim":108.0, - "partner":"6dyc" - }, { "sim":108.0, "partner":"5l31" }, { "sim":108.0, - "partner":"6dyd" + "partner":"6dye" }, { "sim":108.0, @@ -861096,15 +864559,15 @@ }, { "sim":108.0, - "partner":"6dye" + "partner":"5l32" }, { "sim":108.0, - "partner":"5l32" + "partner":"6dhy" }, { "sim":108.0, - "partner":"6dhy" + "partner":"6wza" }, { "sim":108.0, @@ -861112,11 +864575,11 @@ }, { "sim":108.0, - "partner":"6wza" + "partner":"2qla" }, { "sim":108.0, - "partner":"2qla" + "partner":"6dhz" }, { "sim":108.0, @@ -861124,7 +864587,7 @@ }, { "sim":108.0, - "partner":"6dhz" + "partner":"6x8x" }, { "sim":108.0, @@ -861136,20 +864599,28 @@ }, { "sim":108.0, - "partner":"6x8x" + "partner":"1yyj" }, { "sim":108.0, - "partner":"1yyj" + "partner":"6dyb" }, { "sim":108.0, - "partner":"5yo3" + "partner":"6dyc" + }, + { + "sim":108.0, + "partner":"6dyd" }, { "sim":108.0, "partner":"5yo5" }, + { + "sim":108.0, + "partner":"5yo3" + }, { "sim":108.0, "partner":"7xki" @@ -861228,11 +864699,11 @@ }, { "sim":105.0, - "partner":"4jeb" + "partner":"6ot4" }, { "sim":105.0, - "partner":"6ot4" + "partner":"4jeb" }, { "sim":104.0, @@ -861240,15 +864711,15 @@ }, { "sim":104.0, - "partner":"3c62" + "partner":"7rwu" }, { "sim":104.0, - "partner":"3qvz" + "partner":"3c62" }, { "sim":104.0, - "partner":"7rwu" + "partner":"3qvz" }, { "sim":104.0, @@ -861256,11 +864727,11 @@ }, { "sim":104.0, - "partner":"3qw0" + "partner":"7su2" }, { "sim":104.0, - "partner":"7su2" + "partner":"3qw0" }, { "sim":104.0, @@ -861294,26 +864765,18 @@ "sim":104.0, "partner":"1lm3" }, - { - "sim":103.0, - "partner":"6ot7" - }, { "sim":103.0, "partner":"6ovh" }, { "sim":103.0, - "partner":"8drf" + "partner":"8drj" }, { "sim":103.0, "partner":"3c63" }, - { - "sim":103.0, - "partner":"8drj" - }, { "sim":103.0, "partner":"8drl" @@ -861327,8 +864790,12 @@ "partner":"8drd" }, { - "sim":102.0, - "partner":"6ot8" + "sim":103.0, + "partner":"6ot7" + }, + { + "sim":103.0, + "partner":"8drf" }, { "sim":102.0, @@ -861355,8 +864822,8 @@ "partner":"6dyl" }, { - "sim":101.0, - "partner":"5bu7" + "sim":102.0, + "partner":"6ot8" }, { "sim":101.0, @@ -861374,6 +864841,10 @@ "sim":101.0, "partner":"7lsn" }, + { + "sim":101.0, + "partner":"5bu7" + }, { "sim":100.0, "partner":"7dcl" @@ -861398,10 +864869,6 @@ "sim":99.0, "partner":"3hnj" }, - { - "sim":98.0, - "partner":"7lv1" - }, { "sim":98.0, "partner":"7lv4" @@ -861434,6 +864901,10 @@ "sim":98.0, "partner":"7lrv" }, + { + "sim":98.0, + "partner":"7lv1" + }, { "sim":97.0, "partner":"4u9e" @@ -861577,54 +865048,54 @@ "subtitle":"Zn-bound structure of computationally designed homotrimer tp1", "tags":[ "metalloprotein", - "computational design", - "de novo protein" + "de novo protein", + "computational design" ], "keywords":[ - "accuracy", - "parent", - "demonstrate", - "architectures", - "predefined", - "overall", "construction", + "geometries", + "form", "surrounding", - "coordination", - "respectively", - "assemblies", - "approach", - "report", - "although", + "terms", + "design", "metal", + "histidine", + "targeted", + "tris", + "respectively", + "around", + "environment", + "overall", "\u00e5", - "reactivities", - "method", - "constructed", - "geometries", + "oligomeric", + "tp1", + "predefined", "apply", - "targeted", - "two", - "terms", + "report", + "tet4", + "block", + "new", "homotrimeric", - "design", - "centers", + "although", "protein", - "tetrahedral", - "tris", "illustrating", - "tet4", - "block", - "environment", + "architectures", + "tetrahedral", + "approach", + "reactivities", + "constructed", + "accuracy", + "coordination", + "centers", + "demonstrate", + "building", "distinct", - "computational", - "histidine", + "two", + "parent", + "assemblies", "versatility", - "form", - "oligomeric", - "tp1", - "building", - "around", - "new" + "method", + "computational" ], "release_date":"2023-07-05", "publication":"\"Atomically Accurate Design of Metalloproteins with Predefined Coordination Geometries\", J.Am.Chem.Soc., 145, 14208-14214", @@ -861707,15 +865178,15 @@ }, { "sim":124.0, - "partner":"7xta" + "partner":"7xt8" }, { "sim":124.0, - "partner":"7xt8" + "partner":"7xt9" }, { "sim":124.0, - "partner":"7xt9" + "partner":"7xta" }, { "sim":124.0, @@ -861771,15 +865242,15 @@ }, { "sim":123.0, - "partner":"8irt" + "partner":"7cmu" }, { "sim":123.0, - "partner":"7cmu" + "partner":"7cmv" }, { "sim":123.0, - "partner":"7cmv" + "partner":"8irt" }, { "sim":123.0, @@ -861789,10 +865260,6 @@ "sim":123.0, "partner":"7w57" }, - { - "sim":119.0, - "partner":"7wvv" - }, { "sim":119.0, "partner":"7wvw" @@ -861807,20 +865274,24 @@ }, { "sim":119.0, - "partner":"7xy6" + "partner":"7wvv" }, { "sim":119.0, "partner":"7xy7" }, { - "sim":116.0, - "partner":"6rz5" + "sim":119.0, + "partner":"7xy6" }, { "sim":116.0, "partner":"6rz4" }, + { + "sim":116.0, + "partner":"6rz5" + }, { "sim":114.0, "partner":"3foo" @@ -861883,15 +865354,15 @@ }, { "sim":113.0, - "partner":"7koo" + "partner":"7koq" }, { "sim":113.0, - "partner":"7koq" + "partner":"7kox" }, { "sim":113.0, - "partner":"7kox" + "partner":"7koo" }, { "sim":113.0, @@ -861915,43 +865386,43 @@ }, { "sim":112.0, - "partner":"6wz0" + "partner":"6ot9" }, { "sim":112.0, - "partner":"5yo4" + "partner":"6wyu" }, { "sim":112.0, - "partner":"6wz1" + "partner":"6wz2" }, { "sim":112.0, - "partner":"6x7e" + "partner":"6wz3" }, { "sim":112.0, - "partner":"6wyu" + "partner":"6wzc" }, { "sim":112.0, - "partner":"6ot9" + "partner":"6wz7" }, { "sim":112.0, - "partner":"6wz2" + "partner":"6wz0" }, { "sim":112.0, - "partner":"6wz3" + "partner":"6wz1" }, { "sim":112.0, - "partner":"6wzc" + "partner":"6x7e" }, { "sim":112.0, - "partner":"6wz7" + "partner":"5yo4" }, { "sim":112.0, @@ -861959,19 +865430,19 @@ }, { "sim":112.0, - "partner":"6rz6" + "partner":"6rz9" }, { "sim":112.0, - "partner":"6rz7" + "partner":"6rz6" }, { "sim":112.0, - "partner":"6rz8" + "partner":"6rz7" }, { "sim":112.0, - "partner":"6rz9" + "partner":"6rz8" }, { "sim":112.0, @@ -862051,11 +865522,11 @@ }, { "sim":111.0, - "partner":"5awi" + "partner":"6dyi" }, { "sim":111.0, - "partner":"6dyi" + "partner":"5awi" }, { "sim":111.0, @@ -862159,11 +865630,11 @@ }, { "sim":111.0, - "partner":"7f83" + "partner":"7xay" }, { "sim":111.0, - "partner":"7xay" + "partner":"7f83" }, { "sim":111.0, @@ -862187,15 +865658,15 @@ }, { "sim":111.0, - "partner":"7ezc" + "partner":"8gne" }, { "sim":111.0, - "partner":"8gne" + "partner":"7zly" }, { "sim":111.0, - "partner":"7zly" + "partner":"7ezc" }, { "sim":111.0, @@ -862203,71 +865674,71 @@ }, { "sim":111.0, - "partner":"5iu4" + "partner":"5iu7" }, { "sim":111.0, - "partner":"5mzp" + "partner":"5iu8" }, { "sim":111.0, - "partner":"5nlx" + "partner":"5iua" }, { "sim":111.0, - "partner":"6gt3" + "partner":"5iub" }, { "sim":111.0, - "partner":"5iu7" + "partner":"6s0l" }, { "sim":111.0, - "partner":"7aro" + "partner":"5nm2" }, { "sim":111.0, - "partner":"5iu8" + "partner":"6zdr" }, { "sim":111.0, - "partner":"5iua" + "partner":"5nm4" }, { "sim":111.0, - "partner":"5iub" + "partner":"8cic" }, { "sim":111.0, - "partner":"6s0l" + "partner":"5n2r" }, { "sim":111.0, - "partner":"5nm2" + "partner":"6zdv" }, { "sim":111.0, - "partner":"6zdr" + "partner":"6s0q" }, { "sim":111.0, - "partner":"5nm4" + "partner":"6gt3" }, { "sim":111.0, - "partner":"5n2r" + "partner":"5iu4" }, { "sim":111.0, - "partner":"8cic" + "partner":"5mzp" }, { "sim":111.0, - "partner":"6zdv" + "partner":"5nlx" }, { "sim":111.0, - "partner":"6s0q" + "partner":"7aro" }, { "sim":111.0, @@ -862317,22 +865788,10 @@ "sim":111.0, "partner":"5uig" }, - { - "sim":111.0, - "partner":"5uvi" - }, - { - "sim":111.0, - "partner":"6mh8" - }, { "sim":111.0, "partner":"4eiy" }, - { - "sim":111.0, - "partner":"8fyn" - }, { "sim":111.0, "partner":"6jzh" @@ -862355,11 +865814,11 @@ }, { "sim":111.0, - "partner":"5k2b" + "partner":"7pyr" }, { "sim":111.0, - "partner":"7pyr" + "partner":"5k2b" }, { "sim":111.0, @@ -862369,10 +865828,6 @@ "sim":111.0, "partner":"5k2d" }, - { - "sim":111.0, - "partner":"7px4" - }, { "sim":111.0, "partner":"6lpj" @@ -862383,7 +865838,7 @@ }, { "sim":111.0, - "partner":"6lpk" + "partner":"7px4" }, { "sim":111.0, @@ -862391,24 +865846,80 @@ }, { "sim":111.0, - "partner":"5jtb" + "partner":"6lpk" }, { "sim":111.0, "partner":"6lpl" }, + { + "sim":111.0, + "partner":"5jtb" + }, { "sim":111.0, "partner":"5vra" }, { "sim":111.0, - "partner":"6pt3" + "partner":"6mh8" + }, + { + "sim":111.0, + "partner":"5uvi" + }, + { + "sim":111.0, + "partner":"8fyn" + }, + { + "sim":111.0, + "partner":"8rwc" + }, + { + "sim":111.0, + "partner":"8rwd" + }, + { + "sim":111.0, + "partner":"8rwe" + }, + { + "sim":111.0, + "partner":"8rwx" + }, + { + "sim":111.0, + "partner":"8rvw" + }, + { + "sim":111.0, + "partner":"8rw0" + }, + { + "sim":111.0, + "partner":"8rwh" + }, + { + "sim":111.0, + "partner":"8rwi" + }, + { + "sim":111.0, + "partner":"8rw4" + }, + { + "sim":111.0, + "partner":"8rw7" }, { "sim":111.0, "partner":"6pt2" }, + { + "sim":111.0, + "partner":"6pt3" + }, { "sim":111.0, "partner":"8hs2" @@ -862427,11 +865938,11 @@ }, { "sim":111.0, - "partner":"7y1f" + "partner":"6me9" }, { "sim":111.0, - "partner":"6me9" + "partner":"7y1f" }, { "sim":111.0, @@ -862455,11 +865966,15 @@ }, { "sim":111.0, - "partner":"7w0m" + "partner":"7w0n" }, { "sim":111.0, - "partner":"7w0n" + "partner":"8xqi" + }, + { + "sim":111.0, + "partner":"8xqj" }, { "sim":111.0, @@ -862479,12 +865994,32 @@ }, { "sim":111.0, - "partner":"6iiv" + "partner":"8xqe" + }, + { + "sim":111.0, + "partner":"8z7j" + }, + { + "sim":111.0, + "partner":"7w0m" + }, + { + "sim":111.0, + "partner":"8z74" + }, + { + "sim":111.0, + "partner":"8xqf" }, { "sim":111.0, "partner":"6iiu" }, + { + "sim":111.0, + "partner":"6iiv" + }, { "sim":111.0, "partner":"6usf" @@ -862533,10 +866068,6 @@ "sim":111.0, "partner":"5ndz" }, - { - "sim":111.0, - "partner":"7f4h" - }, { "sim":111.0, "partner":"7f4d" @@ -862551,19 +866082,19 @@ }, { "sim":111.0, - "partner":"8hj5" + "partner":"7f4h" }, { "sim":111.0, - "partner":"7dw9" + "partner":"8hj5" }, { "sim":111.0, - "partner":"8hii" + "partner":"8zfz" }, { "sim":111.0, - "partner":"8hij" + "partner":"7dw9" }, { "sim":111.0, @@ -862571,15 +866102,11 @@ }, { "sim":111.0, - "partner":"8dre" - }, - { - "sim":111.0, - "partner":"8f74" + "partner":"8hii" }, { "sim":111.0, - "partner":"8f7b" + "partner":"8hij" }, { "sim":111.0, @@ -862637,17 +866164,29 @@ "sim":111.0, "partner":"8drq" }, + { + "sim":111.0, + "partner":"8dre" + }, + { + "sim":111.0, + "partner":"8f74" + }, + { + "sim":111.0, + "partner":"8f7b" + }, { "sim":110.0, "partner":"6dhy" }, { "sim":110.0, - "partner":"3hni" + "partner":"6wza" }, { "sim":110.0, - "partner":"6wza" + "partner":"3hni" }, { "sim":110.0, @@ -862735,19 +866274,19 @@ }, { "sim":110.0, - "partner":"7y12" + "partner":"7y15" }, { "sim":110.0, - "partner":"7y13" + "partner":"7y12" }, { "sim":110.0, - "partner":"7y14" + "partner":"7y13" }, { "sim":110.0, - "partner":"7y15" + "partner":"7y14" }, { "sim":110.0, @@ -862799,15 +866338,15 @@ }, { "sim":110.0, - "partner":"7zi0" + "partner":"5l7d" }, { "sim":110.0, - "partner":"5l7d" + "partner":"5l7i" }, { "sim":110.0, - "partner":"5l7i" + "partner":"7zi0" }, { "sim":110.0, @@ -862835,15 +866374,15 @@ }, { "sim":109.0, - "partner":"5ym7" + "partner":"6cbv" }, { "sim":109.0, - "partner":"5yo6" + "partner":"5ym7" }, { "sim":109.0, - "partner":"6cbv" + "partner":"5yo6" }, { "sim":109.0, @@ -862901,45 +866440,49 @@ "sim":109.0, "partner":"4l6r" }, + { + "sim":109.0, + "partner":"8x3k" + }, { "sim":108.0, - "partner":"6dyb" + "partner":"6dye" }, { "sim":108.0, - "partner":"6dyc" + "partner":"3m15" }, { "sim":108.0, - "partner":"6dyd" + "partner":"3iq5" }, { "sim":108.0, - "partner":"6dye" + "partner":"6dy4" }, { "sim":108.0, - "partner":"3m15" + "partner":"3iq6" }, { "sim":108.0, - "partner":"3iq5" + "partner":"6dy6" }, { "sim":108.0, - "partner":"3iq6" + "partner":"3m79" }, { "sim":108.0, - "partner":"6dy4" + "partner":"6dyb" }, { "sim":108.0, - "partner":"6dy6" + "partner":"6dyc" }, { "sim":108.0, - "partner":"3m79" + "partner":"6dyd" }, { "sim":108.0, @@ -862947,11 +866490,11 @@ }, { "sim":108.0, - "partner":"8djk" + "partner":"8djm" }, { "sim":108.0, - "partner":"8djm" + "partner":"8djk" }, { "sim":108.0, @@ -862977,10 +866520,6 @@ "sim":108.0, "partner":"6os2" }, - { - "sim":107.0, - "partner":"5bu7" - }, { "sim":107.0, "partner":"5l31" @@ -862994,12 +866533,12 @@ "partner":"8drj" }, { - "sim":106.0, - "partner":"8drf" + "sim":107.0, + "partner":"5bu7" }, { "sim":106.0, - "partner":"3c62" + "partner":"6dyf" }, { "sim":106.0, @@ -863007,7 +866546,7 @@ }, { "sim":106.0, - "partner":"6dyf" + "partner":"3c62" }, { "sim":106.0, @@ -863019,11 +866558,11 @@ }, { "sim":106.0, - "partner":"7su2" + "partner":"6dyh" }, { "sim":106.0, - "partner":"6dyh" + "partner":"7su2" }, { "sim":106.0, @@ -863039,11 +866578,11 @@ }, { "sim":106.0, - "partner":"7rwy" + "partner":"8drl" }, { "sim":106.0, - "partner":"8drl" + "partner":"7rwy" }, { "sim":106.0, @@ -863065,6 +866604,10 @@ "sim":106.0, "partner":"1lm3" }, + { + "sim":106.0, + "partner":"8drf" + }, { "sim":106.0, "partner":"7yit" @@ -863121,18 +866664,10 @@ "sim":103.0, "partner":"4jeb" }, - { - "sim":102.0, - "partner":"6ot7" - }, { "sim":102.0, "partner":"6ovh" }, - { - "sim":102.0, - "partner":"7lv1" - }, { "sim":102.0, "partner":"7lv4" @@ -863147,15 +866682,15 @@ }, { "sim":102.0, - "partner":"7lr5" + "partner":"6dyj" }, { "sim":102.0, - "partner":"7lrr" + "partner":"7lr5" }, { "sim":102.0, - "partner":"6dyj" + "partner":"7lrr" }, { "sim":102.0, @@ -863163,11 +866698,11 @@ }, { "sim":102.0, - "partner":"3hnj" + "partner":"6dyl" }, { "sim":102.0, - "partner":"6dyl" + "partner":"3hnj" }, { "sim":102.0, @@ -863181,6 +866716,14 @@ "sim":102.0, "partner":"7lrv" }, + { + "sim":102.0, + "partner":"6ot7" + }, + { + "sim":102.0, + "partner":"7lv1" + }, { "sim":101.0, "partner":"7dcl" @@ -863197,10 +866740,6 @@ "sim":101.0, "partner":"4er9" }, - { - "sim":100.0, - "partner":"6ot8" - }, { "sim":100.0, "partner":"6lde" @@ -863213,6 +866752,10 @@ "sim":100.0, "partner":"5xzi" }, + { + "sim":100.0, + "partner":"6ot8" + }, { "sim":98.0, "partner":"6ldf" @@ -863363,54 +866906,54 @@ "subtitle":"Apo structure of computationally designed homotrimer tp1", "tags":[ "metalloprotein", - "computational design", - "de novo protein" + "de novo protein", + "computational design" ], "keywords":[ - "accuracy", - "parent", - "demonstrate", - "architectures", - "predefined", - "overall", "construction", + "geometries", + "form", "surrounding", - "coordination", - "respectively", - "assemblies", - "approach", - "report", - "although", + "terms", + "design", "metal", + "histidine", + "targeted", + "tris", + "respectively", + "around", + "environment", + "overall", "\u00e5", - "reactivities", - "method", - "constructed", - "geometries", + "oligomeric", + "tp1", + "predefined", "apply", - "targeted", - "two", - "terms", + "report", + "tet4", + "block", + "new", "homotrimeric", - "design", - "centers", + "although", "protein", - "tetrahedral", - "tris", "illustrating", - "tet4", - "block", - "environment", + "architectures", + "tetrahedral", + "approach", + "reactivities", + "constructed", + "accuracy", + "coordination", + "centers", + "demonstrate", + "building", "distinct", - "computational", - "histidine", + "two", + "parent", + "assemblies", "versatility", - "form", - "oligomeric", - "tp1", - "building", - "around", - "new" + "method", + "computational" ], "release_date":"2023-07-05", "publication":"\"Atomically Accurate Design of Metalloproteins with Predefined Coordination Geometries\", J.Am.Chem.Soc., 145, 14208-14214", @@ -863493,15 +867036,15 @@ }, { "sim":124.0, - "partner":"7xta" + "partner":"7xt8" }, { "sim":124.0, - "partner":"7xt8" + "partner":"7xt9" }, { "sim":124.0, - "partner":"7xt9" + "partner":"7xta" }, { "sim":124.0, @@ -863557,15 +867100,15 @@ }, { "sim":123.0, - "partner":"8irt" + "partner":"7cmu" }, { "sim":123.0, - "partner":"7cmu" + "partner":"7cmv" }, { "sim":123.0, - "partner":"7cmv" + "partner":"8irt" }, { "sim":123.0, @@ -863575,10 +867118,6 @@ "sim":123.0, "partner":"7w57" }, - { - "sim":119.0, - "partner":"7wvv" - }, { "sim":119.0, "partner":"7wvw" @@ -863593,20 +867132,24 @@ }, { "sim":119.0, - "partner":"7xy6" + "partner":"7wvv" }, { "sim":119.0, "partner":"7xy7" }, { - "sim":116.0, - "partner":"6rz5" + "sim":119.0, + "partner":"7xy6" }, { "sim":116.0, "partner":"6rz4" }, + { + "sim":116.0, + "partner":"6rz5" + }, { "sim":114.0, "partner":"3foo" @@ -863669,15 +867212,15 @@ }, { "sim":113.0, - "partner":"7koo" + "partner":"7koq" }, { "sim":113.0, - "partner":"7koq" + "partner":"7kox" }, { "sim":113.0, - "partner":"7kox" + "partner":"7koo" }, { "sim":113.0, @@ -863701,43 +867244,43 @@ }, { "sim":112.0, - "partner":"6wz0" + "partner":"6ot9" }, { "sim":112.0, - "partner":"5yo4" + "partner":"6wyu" }, { "sim":112.0, - "partner":"6wz1" + "partner":"6wz2" }, { "sim":112.0, - "partner":"6x7e" + "partner":"6wz3" }, { "sim":112.0, - "partner":"6wyu" + "partner":"6wzc" }, { "sim":112.0, - "partner":"6ot9" + "partner":"6wz7" }, { "sim":112.0, - "partner":"6wz2" + "partner":"6wz0" }, { "sim":112.0, - "partner":"6wz3" + "partner":"6wz1" }, { "sim":112.0, - "partner":"6wzc" + "partner":"6x7e" }, { "sim":112.0, - "partner":"6wz7" + "partner":"5yo4" }, { "sim":112.0, @@ -863745,19 +867288,19 @@ }, { "sim":112.0, - "partner":"6rz6" + "partner":"6rz9" }, { "sim":112.0, - "partner":"6rz7" + "partner":"6rz6" }, { "sim":112.0, - "partner":"6rz8" + "partner":"6rz7" }, { "sim":112.0, - "partner":"6rz9" + "partner":"6rz8" }, { "sim":112.0, @@ -863837,11 +867380,11 @@ }, { "sim":111.0, - "partner":"5awi" + "partner":"6dyi" }, { "sim":111.0, - "partner":"6dyi" + "partner":"5awi" }, { "sim":111.0, @@ -863945,11 +867488,11 @@ }, { "sim":111.0, - "partner":"7f83" + "partner":"7xay" }, { "sim":111.0, - "partner":"7xay" + "partner":"7f83" }, { "sim":111.0, @@ -863973,15 +867516,15 @@ }, { "sim":111.0, - "partner":"7ezc" + "partner":"8gne" }, { "sim":111.0, - "partner":"8gne" + "partner":"7zly" }, { "sim":111.0, - "partner":"7zly" + "partner":"7ezc" }, { "sim":111.0, @@ -863989,71 +867532,71 @@ }, { "sim":111.0, - "partner":"5iu4" + "partner":"5iu7" }, { "sim":111.0, - "partner":"5mzp" + "partner":"5iu8" }, { "sim":111.0, - "partner":"5nlx" + "partner":"5iua" }, { "sim":111.0, - "partner":"6gt3" + "partner":"5iub" }, { "sim":111.0, - "partner":"5iu7" + "partner":"6s0l" }, { "sim":111.0, - "partner":"7aro" + "partner":"5nm2" }, { "sim":111.0, - "partner":"5iu8" + "partner":"6zdr" }, { "sim":111.0, - "partner":"5iua" + "partner":"5nm4" }, { "sim":111.0, - "partner":"5iub" + "partner":"8cic" }, { "sim":111.0, - "partner":"6s0l" + "partner":"5n2r" }, { "sim":111.0, - "partner":"5nm2" + "partner":"6zdv" }, { "sim":111.0, - "partner":"6zdr" + "partner":"6s0q" }, { "sim":111.0, - "partner":"5nm4" + "partner":"6gt3" }, { "sim":111.0, - "partner":"5n2r" + "partner":"5iu4" }, { "sim":111.0, - "partner":"8cic" + "partner":"5mzp" }, { "sim":111.0, - "partner":"6zdv" + "partner":"5nlx" }, { "sim":111.0, - "partner":"6s0q" + "partner":"7aro" }, { "sim":111.0, @@ -864103,22 +867646,10 @@ "sim":111.0, "partner":"5uig" }, - { - "sim":111.0, - "partner":"5uvi" - }, - { - "sim":111.0, - "partner":"6mh8" - }, { "sim":111.0, "partner":"4eiy" }, - { - "sim":111.0, - "partner":"8fyn" - }, { "sim":111.0, "partner":"6jzh" @@ -864141,11 +867672,11 @@ }, { "sim":111.0, - "partner":"5k2b" + "partner":"7pyr" }, { "sim":111.0, - "partner":"7pyr" + "partner":"5k2b" }, { "sim":111.0, @@ -864155,10 +867686,6 @@ "sim":111.0, "partner":"5k2d" }, - { - "sim":111.0, - "partner":"7px4" - }, { "sim":111.0, "partner":"6lpj" @@ -864169,7 +867696,7 @@ }, { "sim":111.0, - "partner":"6lpk" + "partner":"7px4" }, { "sim":111.0, @@ -864177,24 +867704,80 @@ }, { "sim":111.0, - "partner":"5jtb" + "partner":"6lpk" }, { "sim":111.0, "partner":"6lpl" }, + { + "sim":111.0, + "partner":"5jtb" + }, { "sim":111.0, "partner":"5vra" }, { "sim":111.0, - "partner":"6pt3" + "partner":"6mh8" + }, + { + "sim":111.0, + "partner":"5uvi" + }, + { + "sim":111.0, + "partner":"8fyn" + }, + { + "sim":111.0, + "partner":"8rwc" + }, + { + "sim":111.0, + "partner":"8rwd" + }, + { + "sim":111.0, + "partner":"8rwe" + }, + { + "sim":111.0, + "partner":"8rwx" + }, + { + "sim":111.0, + "partner":"8rvw" + }, + { + "sim":111.0, + "partner":"8rw0" + }, + { + "sim":111.0, + "partner":"8rwh" + }, + { + "sim":111.0, + "partner":"8rwi" + }, + { + "sim":111.0, + "partner":"8rw4" + }, + { + "sim":111.0, + "partner":"8rw7" }, { "sim":111.0, "partner":"6pt2" }, + { + "sim":111.0, + "partner":"6pt3" + }, { "sim":111.0, "partner":"8hs2" @@ -864213,11 +867796,11 @@ }, { "sim":111.0, - "partner":"7y1f" + "partner":"6me9" }, { "sim":111.0, - "partner":"6me9" + "partner":"7y1f" }, { "sim":111.0, @@ -864241,11 +867824,15 @@ }, { "sim":111.0, - "partner":"7w0m" + "partner":"7w0n" }, { "sim":111.0, - "partner":"7w0n" + "partner":"8xqi" + }, + { + "sim":111.0, + "partner":"8xqj" }, { "sim":111.0, @@ -864265,12 +867852,32 @@ }, { "sim":111.0, - "partner":"6iiv" + "partner":"8xqe" + }, + { + "sim":111.0, + "partner":"8z7j" + }, + { + "sim":111.0, + "partner":"7w0m" + }, + { + "sim":111.0, + "partner":"8z74" + }, + { + "sim":111.0, + "partner":"8xqf" }, { "sim":111.0, "partner":"6iiu" }, + { + "sim":111.0, + "partner":"6iiv" + }, { "sim":111.0, "partner":"6usf" @@ -864319,10 +867926,6 @@ "sim":111.0, "partner":"5ndz" }, - { - "sim":111.0, - "partner":"7f4h" - }, { "sim":111.0, "partner":"7f4d" @@ -864337,19 +867940,19 @@ }, { "sim":111.0, - "partner":"8hj5" + "partner":"7f4h" }, { "sim":111.0, - "partner":"7dw9" + "partner":"8hj5" }, { "sim":111.0, - "partner":"8hii" + "partner":"8zfz" }, { "sim":111.0, - "partner":"8hij" + "partner":"7dw9" }, { "sim":111.0, @@ -864357,15 +867960,11 @@ }, { "sim":111.0, - "partner":"8dre" - }, - { - "sim":111.0, - "partner":"8f74" + "partner":"8hii" }, { "sim":111.0, - "partner":"8f7b" + "partner":"8hij" }, { "sim":111.0, @@ -864423,17 +868022,29 @@ "sim":111.0, "partner":"8drq" }, + { + "sim":111.0, + "partner":"8dre" + }, + { + "sim":111.0, + "partner":"8f74" + }, + { + "sim":111.0, + "partner":"8f7b" + }, { "sim":110.0, "partner":"6dhy" }, { "sim":110.0, - "partner":"3hni" + "partner":"6wza" }, { "sim":110.0, - "partner":"6wza" + "partner":"3hni" }, { "sim":110.0, @@ -864521,19 +868132,19 @@ }, { "sim":110.0, - "partner":"7y12" + "partner":"7y15" }, { "sim":110.0, - "partner":"7y13" + "partner":"7y12" }, { "sim":110.0, - "partner":"7y14" + "partner":"7y13" }, { "sim":110.0, - "partner":"7y15" + "partner":"7y14" }, { "sim":110.0, @@ -864585,15 +868196,15 @@ }, { "sim":110.0, - "partner":"7zi0" + "partner":"5l7d" }, { "sim":110.0, - "partner":"5l7d" + "partner":"5l7i" }, { "sim":110.0, - "partner":"5l7i" + "partner":"7zi0" }, { "sim":110.0, @@ -864621,15 +868232,15 @@ }, { "sim":109.0, - "partner":"5ym7" + "partner":"6cbv" }, { "sim":109.0, - "partner":"5yo6" + "partner":"5ym7" }, { "sim":109.0, - "partner":"6cbv" + "partner":"5yo6" }, { "sim":109.0, @@ -864687,45 +868298,49 @@ "sim":109.0, "partner":"4l6r" }, + { + "sim":109.0, + "partner":"8x3k" + }, { "sim":108.0, - "partner":"6dyb" + "partner":"6dye" }, { "sim":108.0, - "partner":"6dyc" + "partner":"3m15" }, { "sim":108.0, - "partner":"6dyd" + "partner":"3iq5" }, { "sim":108.0, - "partner":"6dye" + "partner":"6dy4" }, { "sim":108.0, - "partner":"3m15" + "partner":"3iq6" }, { "sim":108.0, - "partner":"3iq5" + "partner":"6dy6" }, { "sim":108.0, - "partner":"3iq6" + "partner":"3m79" }, { "sim":108.0, - "partner":"6dy4" + "partner":"6dyb" }, { "sim":108.0, - "partner":"6dy6" + "partner":"6dyc" }, { "sim":108.0, - "partner":"3m79" + "partner":"6dyd" }, { "sim":108.0, @@ -864733,11 +868348,11 @@ }, { "sim":108.0, - "partner":"8djk" + "partner":"8djm" }, { "sim":108.0, - "partner":"8djm" + "partner":"8djk" }, { "sim":108.0, @@ -864763,10 +868378,6 @@ "sim":108.0, "partner":"6os2" }, - { - "sim":107.0, - "partner":"5bu7" - }, { "sim":107.0, "partner":"5l31" @@ -864780,12 +868391,12 @@ "partner":"8drj" }, { - "sim":106.0, - "partner":"8drf" + "sim":107.0, + "partner":"5bu7" }, { "sim":106.0, - "partner":"3c62" + "partner":"6dyf" }, { "sim":106.0, @@ -864793,7 +868404,7 @@ }, { "sim":106.0, - "partner":"6dyf" + "partner":"3c62" }, { "sim":106.0, @@ -864805,11 +868416,11 @@ }, { "sim":106.0, - "partner":"7su2" + "partner":"6dyh" }, { "sim":106.0, - "partner":"6dyh" + "partner":"7su2" }, { "sim":106.0, @@ -864825,11 +868436,11 @@ }, { "sim":106.0, - "partner":"7rwy" + "partner":"8drl" }, { "sim":106.0, - "partner":"8drl" + "partner":"7rwy" }, { "sim":106.0, @@ -864851,6 +868462,10 @@ "sim":106.0, "partner":"1lm3" }, + { + "sim":106.0, + "partner":"8drf" + }, { "sim":106.0, "partner":"7yit" @@ -864907,18 +868522,10 @@ "sim":103.0, "partner":"4jeb" }, - { - "sim":102.0, - "partner":"6ot7" - }, { "sim":102.0, "partner":"6ovh" }, - { - "sim":102.0, - "partner":"7lv1" - }, { "sim":102.0, "partner":"7lv4" @@ -864933,15 +868540,15 @@ }, { "sim":102.0, - "partner":"7lr5" + "partner":"6dyj" }, { "sim":102.0, - "partner":"7lrr" + "partner":"7lr5" }, { "sim":102.0, - "partner":"6dyj" + "partner":"7lrr" }, { "sim":102.0, @@ -864949,11 +868556,11 @@ }, { "sim":102.0, - "partner":"3hnj" + "partner":"6dyl" }, { "sim":102.0, - "partner":"6dyl" + "partner":"3hnj" }, { "sim":102.0, @@ -864967,6 +868574,14 @@ "sim":102.0, "partner":"7lrv" }, + { + "sim":102.0, + "partner":"6ot7" + }, + { + "sim":102.0, + "partner":"7lv1" + }, { "sim":101.0, "partner":"7dcl" @@ -864983,10 +868598,6 @@ "sim":101.0, "partner":"4er9" }, - { - "sim":100.0, - "partner":"6ot8" - }, { "sim":100.0, "partner":"6lde" @@ -864999,6 +868610,10 @@ "sim":100.0, "partner":"5xzi" }, + { + "sim":100.0, + "partner":"6ot8" + }, { "sim":98.0, "partner":"6ldf" @@ -865152,11 +868767,11 @@ ], "subtitle":"De novo designed transmembrane antiparallel homo-dimer g-x6-g 01322-42", "tags":[ - "homo-dimer", "computational design", - "single-pass", + "de novo protein", + "homo-dimer", "membrane protein", - "de novo protein" + "single-pass" ], "keywords":[ "description", @@ -865281,97 +868896,97 @@ "de novo protein" ], "keywords":[ - "many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - "mild", - "number", - "materials", - "nature", - "furthermore", - "modularity", - "dynamics", - "positions", - "assembly", - "ease", - "though", + "characterized", + "metal", "nearly", + "reactions", + "interconversion", + "furthermore", + "exceptionally", + "enabled", "thiol", - "permutations", - "framework", - "accelerate", - "transformations", - "molecular", - "expected", "frameworks", - "conditions", - "assemblies", - "calculations", - "reactions", - "redox", - "active", - "landscape", - "synthesis", - "engineering", + "positive", + "sites", + "characterization", + "ions", "several", + "nitric", + "mild", + "including", + "supporting", + "peptide", + "undergo", + "permutations", + "redox", + "toxic", "design", - "functionality", - "characterization", - "cooperative", - "using", - "exceptionally", - "negative", "displayed", - "high", - "importantly", - "underlying", - "nitric", - "notably", - "hindered", - "ion", - "sites", "diverse", - "leveraging", - "delivery", - "noncovalent", - "undergo", - "observations", - "applicable", + "active", + "assembly", + "porous", + "rich", + "synthesis", + "selective", "also", - "rational", + "applicable", + "conditions", + "modularity", + "noncovalent", + "underlying", + "notably", + "oxide", + "versatile", + "reactive", + "landscape", + "unique", + "assemblies", + "materials", + "accelerate", + "cooperative", + "dynamics", "reveal", - "uptake", - "positive", - "selective", + "calculations", + "diffraction", + "many", + "importantly", + "structurally", + "rational", "synthesized", - "biocompatible", - "complex", + "determined", "thiols", - "readily", - "enabled", - "supporting" + "supports", + "interactions", + "ion", + "nature", + "find", + "transformations", + "uptake", + "high", + "negative", + "though", + "observations" ], "release_date":"2023-11-15", "publication":"\"Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks\", J.Am.Chem.Soc., 145, 19588-19600", @@ -865492,97 +869107,97 @@ "de novo protein" ], "keywords":[ - "many", - "oxide", - "metal", - "ions", - "pb", - "peptide", - "including", + "engineering", + "molecular", + "ease", + "functionality", + "number", + "leveraging", + "framework", + "delivery", "cd", - "hg", - "determined", - "find", - "versatile", - "interactions", - "interconversion", - "diffraction", - "structurally", - "rich", - "porous", - "reactive", - "toxic", - "supports", + "pb", + "readily", + "positions", + "biocompatible", "coordination", - "unique", - "characterized", + "hindered", + "expected", + "hg", + "using", + "complex", "reactivity", - "mild", - "number", - "materials", - "nature", - "furthermore", - "modularity", - "dynamics", - "positions", - "assembly", - "ease", - "though", + "characterized", + "metal", "nearly", + "reactions", + "interconversion", + "furthermore", + "exceptionally", + "enabled", "thiol", - "permutations", - "framework", - "accelerate", - "transformations", - "molecular", - "expected", "frameworks", - "conditions", - "assemblies", - "calculations", - "reactions", - "redox", - "active", - "landscape", - "synthesis", - "engineering", + "positive", + "sites", + "characterization", + "ions", "several", + "nitric", + "mild", + "including", + "supporting", + "peptide", + "undergo", + "permutations", + "redox", + "toxic", "design", - "functionality", - "characterization", - "cooperative", - "using", - "exceptionally", - "negative", "displayed", - "high", - "importantly", - "underlying", - "nitric", - "notably", - "hindered", - "ion", - "sites", "diverse", - "leveraging", - "delivery", - "noncovalent", - "undergo", - "observations", - "applicable", + "active", + "assembly", + "porous", + "rich", + "synthesis", + "selective", "also", - "rational", + "applicable", + "conditions", + "modularity", + "noncovalent", + "underlying", + "notably", + "oxide", + "versatile", + "reactive", + "landscape", + "unique", + "assemblies", + "materials", + "accelerate", + "cooperative", + "dynamics", "reveal", - "uptake", - "positive", - "selective", + "calculations", + "diffraction", + "many", + "importantly", + "structurally", + "rational", "synthesized", - "biocompatible", - "complex", + "determined", "thiols", - "readily", - "enabled", - "supporting" + "supports", + "interactions", + "ion", + "nature", + "find", + "transformations", + "uptake", + "high", + "negative", + "though", + "observations" ], "release_date":"2023-11-15", "publication":"\"Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks\", J.Am.Chem.Soc., 145, 19588-19600", @@ -865801,98 +869416,98 @@ "o32-zl4" ], "keywords":[ + "unpredictable", "largely", - "oligomers", - "architecture", - "systematically", - "challenge", - "designed", - "lattice", - "dimensions", + "engineering", + "role", + "structural", + "number", + "outstanding", + "information", + "group", + "three", "mixing", - "provide", - "unpredictable", + "degrees", + "protein", + "across", + "general", "purified", "crystal", - "extremely", - "sequences", - "interactions", - "designing", - "primary", - "porous", + "stable", + "100", + "corresponding", + "encoded", + "enables", + "engineered", + "nearly", + "overall", + "biological", + "specific", + "prespecified", "contacts", + "extremely", + "approach", "develop", - "interfaces", - "general", - "architectures", - "models", - "redesigned", - "cell", - "enables", + "packing", "process", - "outstanding", - "number", - "remains", + "accuracy", + "architecture", "highly", - "materials", - "structures", - "upon", - "empirical", - "atomic", + "freedom", + "computational", "pairs", - "three", - "hierarchically", - "corresponding", - "assembly", - "biology", - "nearly", - "role", - "preferences", + "designing", + "symmetry", + "design", + "individually", "\u00b5m", + "redesigned", + "atomic", + "biology", + "empirical", + "assembly", "platform", + "porous", + "preferences", + "precisely", + "cell", + "architectures", + "constrains", + "understood", + "spontaneously", + "primary", + "upon", + "system", + "retaining", + "crystals", + "identical", + "materials", + "hierarchically", + "designed", + "central", + "models", + "dimensions", + "poorly", + "sequences", + "space", + "interfaces", + "structures", + "oligomers", + "remains", "crystallization", - "plays", + "provide", "powerful", - "100", - "group", - "programming", - "freedom", - "information", "closely", - "specific", - "engineering", - "constrains", + "interactions", + "plays", + "programming", "unit", - "design", - "across", - "symmetry", + "lattice", "high", - "prespecified", - "encoded", - "biological", - "retaining", - "individually", - "packing", - "structural", - "accuracy", - "poorly", - "overall", "despite", - "approach", - "stable", - "engineered", - "understood", - "precisely", - "system", "arrangements", - "central", - "spontaneously", - "protein", - "degrees", - "identical", - "space", - "computational", - "crystals" + "challenge", + "systematically" ], "release_date":"2023-11-01", "publication":"\"Accurate computational design of three-dimensional protein crystals\", Nat Mater, 22, 1556-1563", @@ -866112,99 +869727,99 @@ ], "subtitle":"De novo design of high-affinity protein binders to bioactive helical peptides", "tags":[ - "deep learning", + "alpha-helical peptides", "de novo protein", - "protein design", "diffusion", - "alpha-helical peptides" + "deep learning", + "protein design" ], "keywords":[ - "many", - "propensity", - "distributions", - "clinical", - "parametric", - "specificity", - "challenge", - "peptide", - "designed", - "sensitive", - "generated", - "hormone", - "variable", - "methods", - "show", - "interactions", - "8", - "successive", - "designing", - "structure", - "optimize", - "conformationally", - "denoising", - "broadly", - "however", "affinity", - "starting", "disease", - "enrichment", - "without", + "show", + "methods", + "experimental", + "biosensors", + "short", + "protein", + "mass", "5", - "structured", + "helical", + "binding", "refining", - "proteins", - "models", + "novo", + "subsequent", + "parametric", + "either", + "deep", + "construction", + "however", + "specificity", + "distributions", + "starting", + "targets", + "input", + "address", + "optimization", + "useful", "rfdiffusion", - "receptors", - "random", - "de", + "completely", + "propensity", + "proteins", "binder", + "parathyroid", + "enrichment", + "unmet", + "peptide", "detection", - "short", - "management", + "variable", + "glucagon", + "designing", + "design", "binders", - "ability", - "better", "natural", - "either", + "clinical", + "successive", + "hormones", + "ability", + "broadly", + "peptides", + "describe", + "noising", + "could", + "optimize", + "extending", "form", - "contribute", + "designed", + "models", "generation", - "noising", - "subsequent", + "many", + "receptors", + "de", + "contribute", + "conformationally", + "partial", + "structured", + "without", + "structure", "generate", - "optimization", - "address", - "useful", - "design", - "biosensors", - "helical", + "flexible", + "interactions", + "hormone", + "random", + "enable", + "management", + "high", + "generated", "noise", + "denoising", "diffusion", - "describe", - "high", - "could", - "input", - "completely", + "challenge", "designs", - "glucagon", - "construction", - "novo", - "flexible", - "experimental", - "peptides", - "parathyroid", - "enable", - "partial", - "protein", "spectrometry", - "targets", - "unmet", - "mass", - "hormones", - "extending", - "deep", - "binding" + "better", + "8", + "sensitive" ], "release_date":"2024-01-10", "publication":"\"De novo design of high-affinity binders of bioactive helical peptides\", Nature, 626, 435-442", @@ -866326,113 +869941,113 @@ ], "keywords":[ "largely", - "\u03b2", + "anchored", + "minimum", + "learning", + "intrinsically", + "around", + "observable", + "canonical", "results", - "restricted", - "peptide", - "designed", + "new", + "machine", + "folding", + "residue", + "model", + "nonredundant", "physicochemical", - "example", - "broad", - "current", - "potential", - "features", - "based", - "sequences", + "protein", + "study", + "network", + "31", + "neural", + "biomedical", "\u03b1", - "expand", - "generates", - "structure", + "essential", + "novo", + "generative", "establish", - "fields", + "secondary", + "using", + "deep", + "conformational", + "limits", + "volume", + "synthesize", + "respectively", + "biological", + "50", + "helix", + "preliminary", "intended", - "distinguishes", - "ncbi", - "hydrophobicity", - "nonredundant", - "biomedical", - "network", - "models", + "derived", + "20", + "approach", "proteins", - "unique", - "specifically", - "de", - "beyond", - "volume", + "accuracy", + "broad", "universe", - "evolutionary", - "generative", + "created", + "features", + "restricted", + "identities", + "peptide", + "lack", + "property", + "pdb", + "robustly", "highlight", - "structures", - "derived", - "foundation", - "essential", "theoretical", - "disordered", - "minimum", - "compared", - "intrinsically", - "created", - "properties", - "data", - "homology", - "amino", - "31", - "respectively", - "synthesize", - "adversarial", - "artificial", - "anchored", - "acids", - "frontier", - "limits", - "landscape", - "canonical", - "application", "design", - "model", - "using", + "beta", "context", - "secondary", - "existing", - "96", - "promising", - "neural", - "sequence", - "biological", - "property", + "compared", + "current", "extant", - "learning", - "around", - "machine", - "accuracy", - "pdb", - "identities", - "robustly", + "potential", "tested", - "conformational", - "lack", - "approach", - "study", - "novo", - "way", + "application", + "properties", "fold", - "peptides", - "observable", + "beyond", + "disordered", + "hydrophobicity", + "amino", + "foundation", + "generates", "databases", + "promising", + "sequence", + "peptides", + "expand", + "landscape", + "frontier", + "unique", + "96", + "ncbi", + "evolutionary", + "evolutionarily", + "designed", + "example", + "models", + "sequences", + "way", "custom", - "50", - "protein", - "residue", - "helix", - "preliminary", - "beta", + "structures", + "de", + "based", "hairpin", - "20", - "deep", - "folding", - "evolutionarily", - "new" + "\u03b2", + "specifically", + "structure", + "distinguishes", + "fields", + "adversarial", + "artificial", + "acids", + "existing", + "data", + "homology" ], "release_date":"2023-06-28", "publication":"\"Generative beta-hairpin design using a residue-based physicochemical property landscape\", Biophys.J., 123, 2790-2806", @@ -866553,113 +870168,113 @@ ], "keywords":[ "largely", - "\u03b2", + "anchored", + "minimum", + "learning", + "intrinsically", + "around", + "observable", + "canonical", "results", - "restricted", - "peptide", - "designed", + "new", + "machine", + "folding", + "residue", + "model", + "nonredundant", "physicochemical", - "example", - "broad", - "current", - "potential", - "features", - "based", - "sequences", + "protein", + "study", + "network", + "31", + "neural", + "biomedical", "\u03b1", - "expand", - "generates", - "structure", + "essential", + "novo", + "generative", "establish", - "fields", + "secondary", + "using", + "deep", + "conformational", + "limits", + "volume", + "synthesize", + "respectively", + "biological", + "50", + "helix", + "preliminary", "intended", - "distinguishes", - "ncbi", - "hydrophobicity", - "nonredundant", - "biomedical", - "network", - "models", + "derived", + "20", + "approach", "proteins", - "unique", - "specifically", - "de", - "beyond", - "volume", + "accuracy", + "broad", "universe", - "evolutionary", - "generative", + "created", + "features", + "restricted", + "identities", + "peptide", + "lack", + "property", + "pdb", + "robustly", "highlight", - "structures", - "derived", - "foundation", - "essential", "theoretical", - "disordered", - "minimum", - "compared", - "intrinsically", - "created", - "properties", - "data", - "homology", - "amino", - "31", - "respectively", - "synthesize", - "adversarial", - "artificial", - "anchored", - "acids", - "frontier", - "limits", - "landscape", - "canonical", - "application", "design", - "model", - "using", + "beta", "context", - "secondary", - "existing", - "96", - "promising", - "neural", - "sequence", - "biological", - "property", + "compared", + "current", "extant", - "learning", - "around", - "machine", - "accuracy", - "pdb", - "identities", - "robustly", + "potential", "tested", - "conformational", - "lack", - "approach", - "study", - "novo", - "way", + "application", + "properties", "fold", - "peptides", - "observable", + "beyond", + "disordered", + "hydrophobicity", + "amino", + "foundation", + "generates", "databases", + "promising", + "sequence", + "peptides", + "expand", + "landscape", + "frontier", + "unique", + "96", + "ncbi", + "evolutionary", + "evolutionarily", + "designed", + "example", + "models", + "sequences", + "way", "custom", - "50", - "protein", - "residue", - "helix", - "preliminary", - "beta", + "structures", + "de", + "based", "hairpin", - "20", - "deep", - "folding", - "evolutionarily", - "new" + "\u03b2", + "specifically", + "structure", + "distinguishes", + "fields", + "adversarial", + "artificial", + "acids", + "existing", + "data", + "homology" ], "release_date":"2023-06-28", "publication":"\"Generative beta-hairpin design using a residue-based physicochemical property landscape\", Biophys.J., 123, 2790-2806", @@ -866780,113 +870395,113 @@ ], "keywords":[ "largely", - "\u03b2", + "anchored", + "minimum", + "learning", + "intrinsically", + "around", + "observable", + "canonical", "results", - "restricted", - "peptide", - "designed", + "new", + "machine", + "folding", + "residue", + "model", + "nonredundant", "physicochemical", - "example", - "broad", - "current", - "potential", - "features", - "based", - "sequences", + "protein", + "study", + "network", + "31", + "neural", + "biomedical", "\u03b1", - "expand", - "generates", - "structure", + "essential", + "novo", + "generative", "establish", - "fields", + "secondary", + "using", + "deep", + "conformational", + "limits", + "volume", + "synthesize", + "respectively", + "biological", + "50", + "helix", + "preliminary", "intended", - "distinguishes", - "ncbi", - "hydrophobicity", - "nonredundant", - "biomedical", - "network", - "models", + "derived", + "20", + "approach", "proteins", - "unique", - "specifically", - "de", - "beyond", - "volume", + "accuracy", + "broad", "universe", - "evolutionary", - "generative", + "created", + "features", + "restricted", + "identities", + "peptide", + "lack", + "property", + "pdb", + "robustly", "highlight", - "structures", - "derived", - "foundation", - "essential", "theoretical", - "disordered", - "minimum", - "compared", - "intrinsically", - "created", - "properties", - "data", - "homology", - "amino", - "31", - "respectively", - "synthesize", - "adversarial", - "artificial", - "anchored", - "acids", - "frontier", - "limits", - "landscape", - "canonical", - "application", "design", - "model", - "using", + "beta", "context", - "secondary", - "existing", - "96", - "promising", - "neural", - "sequence", - "biological", - "property", + "compared", + "current", "extant", - "learning", - "around", - "machine", - "accuracy", - "pdb", - "identities", - "robustly", + "potential", "tested", - "conformational", - "lack", - "approach", - "study", - "novo", - "way", + "application", + "properties", "fold", - "peptides", - "observable", + "beyond", + "disordered", + "hydrophobicity", + "amino", + "foundation", + "generates", "databases", + "promising", + "sequence", + "peptides", + "expand", + "landscape", + "frontier", + "unique", + "96", + "ncbi", + "evolutionary", + "evolutionarily", + "designed", + "example", + "models", + "sequences", + "way", "custom", - "50", - "protein", - "residue", - "helix", - "preliminary", - "beta", + "structures", + "de", + "based", "hairpin", - "20", - "deep", - "folding", - "evolutionarily", - "new" + "\u03b2", + "specifically", + "structure", + "distinguishes", + "fields", + "adversarial", + "artificial", + "acids", + "existing", + "data", + "homology" ], "release_date":"2023-06-28", "publication":"\"Generative beta-hairpin design using a residue-based physicochemical property landscape\", Biophys.J., 123, 2790-2806", @@ -867033,87 +870648,87 @@ ], "subtitle":"Crystal structure of t33-18.2: deep-learning sequence design of co-assembling tetrahedron protein nanoparticles", "tags":[ + "de novo design", + "de novo protein", "tetrahedrons", "rosetta", - "proteinmpnn", - "de novo protein", "deep-learning", - "de novo design" + "proteinmpnn" ], "keywords":[ - "manual", - "13", - "accuracy", - "interfaces", - "performance", - "benchmark", - "orders", - "results", - "showcase", - "proteinmpnn", - "refinement", - "components", - "similar", - "assemblies", - "substantial", - "wide", - "success", - "resolution", + "researchers", + "designed", "independently", - "rosetta", + "rate", + "design", + "resources", "problems", - "yielding", - "computation", - "test", - "less", - "expert", - "method", - "enable", - "designed", - "substantially", - "confirmed", - "requires", - "interface", - "purified", - "biologists", + "interfaces", + "structural", + "learning", + "resolution", "methods", + "structures", + "orders", + "computation", "experimentally", - "vitro", - "crystal", - "ability", - "rate", + "benchmark", + "13", + "showcase", "potential", + "widespread", + "assembly", "application", + "rosetta", + "results", "polar", - "several", - "design", - "simplify", - "structures", - "promise", + "new", + "various", "protein", - "using", - "tetrahedral", - "required", + "manual", + "performance", "facilitated", - "researchers", - "variety", + "wide", + "tetrahedral", + "disciplines", + "vitro", + "accuracy", + "several", + "enable", + "scientific", "nanomaterials", - "assembly", - "sequence", + "ability", + "yielding", + "success", + "confirmed", + "biologists", "high", - "various", - "widespread", - "resources", - "computational", - "scientific", + "test", + "simplify", + "requires", + "interface", + "sequence", + "magnitude", + "substantially", + "components", + "promise", + "expert", + "purified", + "variety", "unlock", - "disciplines", + "crystal", + "assemblies", + "refinement", + "method", + "substantial", + "computational", + "using", + "required", + "similar", + "proteinmpnn", + "less", "deep", - "magnitude", - "learning", - "biotechnology", - "structural", - "new" + "biotechnology" ], "release_date":"2024-04-24", "publication":"\"Rapid and automated design of two-component protein nanomaterials using ProteinMPNN\", Proc.Natl.Acad.Sci.USA, 121, e2314646121-e2314646121", @@ -867147,6 +870762,62 @@ ], "seq_thr_sim_natural":[ + { + "sim":195.0, + "partner":"3mf7" + }, + { + "sim":195.0, + "partner":"3mf8" + }, + { + "sim":193.0, + "partner":"2flz" + }, + { + "sim":193.0, + "partner":"2flt" + }, + { + "sim":68.0, + "partner":"7m58" + }, + { + "sim":67.0, + "partner":"3n4d" + }, + { + "sim":67.0, + "partner":"3n4g" + }, + { + "sim":67.0, + "partner":"3n4h" + }, + { + "sim":67.0, + "partner":"7ms0" + }, + { + "sim":66.0, + "partner":"7ms9" + }, + { + "sim":66.0, + "partner":"7ms8" + }, + { + "sim":65.0, + "partner":"7ms3" + }, + { + "sim":64.0, + "partner":"7ms1" + }, + { + "sim":50.0, + "partner":"3c6v" + }, { "sim":185.0, "partner":"1vhf" @@ -867258,62 +870929,6 @@ { "sim":52.0, "partner":"4y6i" - }, - { - "sim":195.0, - "partner":"3mf7" - }, - { - "sim":195.0, - "partner":"3mf8" - }, - { - "sim":193.0, - "partner":"2flz" - }, - { - "sim":193.0, - "partner":"2flt" - }, - { - "sim":68.0, - "partner":"7m58" - }, - { - "sim":67.0, - "partner":"3n4d" - }, - { - "sim":67.0, - "partner":"3n4g" - }, - { - "sim":67.0, - "partner":"3n4h" - }, - { - "sim":67.0, - "partner":"7ms0" - }, - { - "sim":66.0, - "partner":"7ms8" - }, - { - "sim":66.0, - "partner":"7ms9" - }, - { - "sim":65.0, - "partner":"7ms3" - }, - { - "sim":64.0, - "partner":"7ms1" - }, - { - "sim":50.0, - "partner":"3c6v" } ], "struct_thr_sim_designed":[ @@ -867441,87 +871056,87 @@ ], "subtitle":"Crystal structure of t33-28.3: deep-learning sequence design of co-assembling tetrahedron protein nanoparticles", "tags":[ + "de novo design", + "de novo protein", "tetrahedrons", "rosetta", - "proteinmpnn", - "de novo protein", "deep-learning", - "de novo design" + "proteinmpnn" ], "keywords":[ - "manual", - "13", - "accuracy", - "interfaces", - "performance", - "benchmark", - "orders", - "results", - "showcase", - "proteinmpnn", - "refinement", - "components", - "similar", - "assemblies", - "substantial", - "wide", - "success", - "resolution", + "researchers", + "designed", "independently", - "rosetta", + "rate", + "design", + "resources", "problems", - "yielding", - "computation", - "test", - "less", - "expert", - "method", - "enable", - "designed", - "substantially", - "confirmed", - "requires", - "interface", - "purified", - "biologists", + "interfaces", + "structural", + "learning", + "resolution", "methods", + "structures", + "orders", + "computation", "experimentally", - "vitro", - "crystal", - "ability", - "rate", + "benchmark", + "13", + "showcase", "potential", + "widespread", + "assembly", "application", + "rosetta", + "results", "polar", - "several", - "design", - "simplify", - "structures", - "promise", + "new", + "various", "protein", - "using", - "tetrahedral", - "required", + "manual", + "performance", "facilitated", - "researchers", - "variety", + "wide", + "tetrahedral", + "disciplines", + "vitro", + "accuracy", + "several", + "enable", + "scientific", "nanomaterials", - "assembly", - "sequence", + "ability", + "yielding", + "success", + "confirmed", + "biologists", "high", - "various", - "widespread", - "resources", - "computational", - "scientific", + "test", + "simplify", + "requires", + "interface", + "sequence", + "magnitude", + "substantially", + "components", + "promise", + "expert", + "purified", + "variety", "unlock", - "disciplines", + "crystal", + "assemblies", + "refinement", + "method", + "substantial", + "computational", + "using", + "required", + "similar", + "proteinmpnn", + "less", "deep", - "magnitude", - "learning", - "biotechnology", - "structural", - "new" + "biotechnology" ], "release_date":"2024-04-24", "publication":"\"Rapid and automated design of two-component protein nanomaterials using ProteinMPNN\", Proc.Natl.Acad.Sci.USA, 121, e2314646121-e2314646121", @@ -867584,6 +871199,10 @@ ], "struct_thr_sim_natural":[ + { + "sim":0.9875000119, + "partner":"3fuy" + }, { "sim":0.9811000228, "partner":"3fwu" @@ -867591,10 +871210,6 @@ { "sim":0.9825999737, "partner":"4nwr" - }, - { - "sim":0.9875000119, - "partner":"3fuy" } ], "seq_max_sim_designed":[ @@ -867705,87 +871320,87 @@ ], "subtitle":"Crystal structure of t33-27.1: deep-learning sequence design of co-assembling tetrahedron protein nanoparticles", "tags":[ + "de novo design", + "de novo protein", "tetrahedrons", "rosetta", - "proteinmpnn", - "de novo protein", "deep-learning", - "de novo design" + "proteinmpnn" ], "keywords":[ - "manual", - "13", - "accuracy", - "interfaces", - "performance", - "benchmark", - "orders", - "results", - "showcase", - "proteinmpnn", - "refinement", - "components", - "similar", - "assemblies", - "substantial", - "wide", - "success", - "resolution", + "researchers", + "designed", "independently", - "rosetta", + "rate", + "design", + "resources", "problems", - "yielding", - "computation", - "test", - "less", - "expert", - "method", - "enable", - "designed", - "substantially", - "confirmed", - "requires", - "interface", - "purified", - "biologists", + "interfaces", + "structural", + "learning", + "resolution", "methods", + "structures", + "orders", + "computation", "experimentally", - "vitro", - "crystal", - "ability", - "rate", + "benchmark", + "13", + "showcase", "potential", + "widespread", + "assembly", "application", + "rosetta", + "results", "polar", - "several", - "design", - "simplify", - "structures", - "promise", + "new", + "various", "protein", - "using", - "tetrahedral", - "required", + "manual", + "performance", "facilitated", - "researchers", - "variety", + "wide", + "tetrahedral", + "disciplines", + "vitro", + "accuracy", + "several", + "enable", + "scientific", "nanomaterials", - "assembly", - "sequence", + "ability", + "yielding", + "success", + "confirmed", + "biologists", "high", - "various", - "widespread", - "resources", - "computational", - "scientific", + "test", + "simplify", + "requires", + "interface", + "sequence", + "magnitude", + "substantially", + "components", + "promise", + "expert", + "purified", + "variety", "unlock", - "disciplines", + "crystal", + "assemblies", + "refinement", + "method", + "substantial", + "computational", + "using", + "required", + "similar", + "proteinmpnn", + "less", "deep", - "magnitude", - "learning", - "biotechnology", - "structural", - "new" + "biotechnology" ], "release_date":"2024-04-24", "publication":"\"Rapid and automated design of two-component protein nanomaterials using ProteinMPNN\", Proc.Natl.Acad.Sci.USA, 121, e2314646121-e2314646121", @@ -867834,10 +871449,6 @@ } ], "seq_thr_sim_natural":[ - { - "sim":281.0, - "partner":"3ejv" - }, { "sim":321.0, "partner":"3n79" @@ -867885,6 +871496,10 @@ { "sim":52.0, "partner":"6ner" + }, + { + "sim":281.0, + "partner":"3ejv" } ], "struct_thr_sim_designed":[ @@ -868117,89 +871732,89 @@ ], "subtitle":"Integrin alpha-v beta-8 in complex with minibinder b8_bp_dsulf", "tags":[ - "signaling", "tgf-beta", - "heterodimer", + "complex", "de novo protein", - "complex" + "signaling", + "heterodimer" ], "keywords":[ - "stability", - "thermal", - "hence", - "\u03b1v\u03b28", - "considerable", - "importance", - "overall", - "fibrotic", + "molecule", + "affinity", + "designed", + "potently", + "designing", + "homologous", "models", - "proteins", + "fibrosis", + "miniproteins", "conformational", + "design", + "hyperstable", + "show", + "structures", "complexes", - "close", - "de", "discriminate", - "clinically", - "antibody", "single", - "inhibitor", - "novo", - "miniproteins", - "method", - "homologous", - "designed", - "lung", + "de", "generalized", - "demonstrating", - "small", + "hence", "approaches", - "needed", - "selectivity", + "computationally", + "fibrotic", + "overall", + "mechanics", + "potential", + "properties", + "rgd", "specific", - "improved", - "validated", + "selective", "heterodimer", + "lung", + "targets", + "inhibitor", "new", - "state", + "therapeutic", "burden", - "\u03b1v\u03b26", - "stabilize", - "picomolar", - "integrins", - "design", - "selective", - "show", - "mouse", - "fibrosis", + "integrin", "model", - "structures", - "rgd", + "thermal", + "cryoem", + "state", + "\u03b1v\u03b28", + "inhibitors", "bind", + "selectivity", + "stability", "reduced", + "improved", + "proteins", + "binding", + "utility", + "close", + "validated", + "considerable", + "high", + "novo", + "compounds", "states", - "targets", + "small", + "picomolar", + "\u03b1v\u03b26", "existing", - "designing", + "integrins", + "stabilize", "describe", - "high", - "mechanics", - "cryoem", - "hyperstable", - "compounds", - "computationally", - "potently", - "could", - "inhibitors", - "integrin", + "mouse", + "demonstrating", + "method", + "clinically", "computational", - "potential", - "affinity", "cancer", - "therapeutic", - "binding", - "molecule", - "utility", - "properties" + "importance", + "could", + "antibody", + "needed" ], "release_date":"2023-09-27", "publication":"\"De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8\", Nat Commun, 14, 5660-5660", @@ -868472,89 +872087,89 @@ ], "subtitle":"Integrin alpha-v beta-6 in complex with minibinder b6_bp_dslf", "tags":[ + "complex", + "de novo protein", "signaling", "heterodimer", - "ecm-binding", - "de novo protein", - "complex" + "ecm-binding" ], "keywords":[ - "stability", - "thermal", - "hence", - "\u03b1v\u03b28", - "considerable", - "importance", - "overall", - "fibrotic", + "molecule", + "affinity", + "designed", + "potently", + "designing", + "homologous", "models", - "proteins", + "fibrosis", + "miniproteins", "conformational", + "design", + "hyperstable", + "show", + "structures", "complexes", - "close", - "de", "discriminate", - "clinically", - "antibody", "single", - "inhibitor", - "novo", - "miniproteins", - "method", - "homologous", - "designed", - "lung", + "de", "generalized", - "demonstrating", - "small", + "hence", "approaches", - "needed", - "selectivity", + "computationally", + "fibrotic", + "overall", + "mechanics", + "potential", + "properties", + "rgd", "specific", - "improved", - "validated", + "selective", "heterodimer", + "lung", + "targets", + "inhibitor", "new", - "state", + "therapeutic", "burden", - "\u03b1v\u03b26", - "stabilize", - "picomolar", - "integrins", - "design", - "selective", - "show", - "mouse", - "fibrosis", + "integrin", "model", - "structures", - "rgd", + "thermal", + "cryoem", + "state", + "\u03b1v\u03b28", + "inhibitors", "bind", + "selectivity", + "stability", "reduced", + "improved", + "proteins", + "binding", + "utility", + "close", + "validated", + "considerable", + "high", + "novo", + "compounds", "states", - "targets", + "small", + "picomolar", + "\u03b1v\u03b26", "existing", - "designing", + "integrins", + "stabilize", "describe", - "high", - "mechanics", - "cryoem", - "hyperstable", - "compounds", - "computationally", - "potently", - "could", - "inhibitors", - "integrin", + "mouse", + "demonstrating", + "method", + "clinically", "computational", - "potential", - "affinity", "cancer", - "therapeutic", - "binding", - "molecule", - "utility", - "properties" + "importance", + "could", + "antibody", + "needed" ], "release_date":"2023-09-27", "publication":"\"De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8\", Nat Commun, 14, 5660-5660", @@ -868779,114 +872394,114 @@ ], "subtitle":"Cryoem structure of a computationally designed t3 tetrahedral nanocage", "tags":[ - "expandable nanomaterials", - "computationally designed", "t3 tetrahedral nanocage", - "expandable nanomaterial", + "de novo", "de novo protein", - "nanocage", - "de novo" + "computationally designed", + "expandable nanomaterials", + "expandable nanomaterial", + "nanocage" ], "keywords":[ "largely", - "oligomers", - "many", + "regularity", + "specified", + "number", + "owing", + "well", + "nested", + "wooden", + "protein", + "readily", + "linear", + "electron", + "blueprinted", + "microscopy", + "straightforward", + "house", + "circular", + "multicomponent", + "standards", + "secondary", + "envelope", + "using", + "placement", + "geometric", + "construction", + "complex", + "enables", "conform", - "inherit", + "backbones", + "comparison", + "enabling", + "polygonal", + "surfaces", + "track", + "blocks", "modules", - "crystallography", - "extendable", - "designed", - "geometries", - "deliberate", - "curved", + "large", "shapes", - "envelope", - "irregular", - "geometric", + "deliberate", + "pieces", + "1", + "geometries", + "consists", "blueprints", - "interactions", - "validate", - "structure", - "owing", - "building", + "design", + "onto", "principles", - "backbones", - "interaction", - "extendability", - "enables", - "straightforward", - "house", - "linear", - "angled", - "number", - "simple", + "expanded", + "simplicity", "geometrical", - "wooden", - "concentrically", - "relationships", - "onto", - "structures", - "nanomaterial", - "complexity", - "pieces", - "polygonal", - "circular", - "unbounded", - "much", + "simple", + "possible", + "different", + "sizes", "platform", - "previously", + "straight", + "architectural", "nanocages", - "polyhedral", - "regularity", - "specified", - "large", - "nested", + "complexity", + "relationships", + "build", + "validate", + "extendability", + "lumber", + "interaction", + "varying", + "nanomaterials", + "building", + "describe", "assemblies", + "designed", + "reinforced", + "concentrically", + "contracted", + "nanomaterial", + "curved", + "many", + "unbounded", + "structures", "ranging", - "1", - "lumber", - "surfaces", + "reconfigurable", + "polyhedral", + "oligomers", + "previously", + "structure", + "extendable", + "frame", "according", - "straight", + "irregular", + "crystallography", + "interactions", + "angled", + "regular", "blank", - "blocks", - "comparison", - "design", + "much", "canvas", - "using", - "secondary", - "describe", - "nanomaterials", - "architectural", - "reinforced", - "enabling", - "multicomponent", + "struts", "designs", - "build", - "construction", - "track", - "placement", - "sizes", - "electron", - "well", - "different", - "contracted", - "protein", - "regular", - "microscopy", - "frame", - "standards", - "complex", - "reconfigurable", - "readily", - "blueprinted", - "varying", - "consists", - "simplicity", - "possible", - "expanded", - "struts" + "inherit" ], "release_date":"2024-03-13", "publication":"\"Blueprinting extendable nanomaterials with standardized protein blocks\", Nature, 627, 898-904", @@ -868986,14 +872601,14 @@ ], "subtitle":"Computationally designed tunable c2 symmetric tandem repeat homodimer, d_3_633_8x without peptide", "tags":[ - "homodimer", - "computational", "designed", - "c2 symmetric", - "de novo protein", + "homodimer", "de novo", + "de novo protein", "circular tandem repeat protein", - "ctrp" + "c2 symmetric", + "ctrp", + "computational" ], "keywords":[ "description", @@ -869141,15 +872756,15 @@ ], "subtitle":"Computationally designed tunable c2 symmetric tandem repeat homodimer, d_3_633_8x bound to peptide", "tags":[ - "homodimer", - "computational", "designed", - "c2 symmetric", - "de novo protein", + "homodimer", "de novo", + "de novo protein", "circular tandem repeat protein", - "cyclic peptide", - "ctrp" + "c2 symmetric", + "ctrp", + "computational", + "cyclic peptide" ], "keywords":[ "description", @@ -869337,80 +872952,80 @@ ], "subtitle":"De novo designed protein binds poly adp ribose polymerase inhibitors (parpi) - apo", "tags":[ - "4-helix bundle", - "drug binding", - "de novo protein", + "de novo design", "parpi", - "de novo design" + "de novo protein", + "4-helix bundle", + "drug binding" ], "keywords":[ - "series", - "accuracy", - "conclude", - "exciting", - "5", - "require", - "excellent", + "designed", + "simulations", + "typically", + "calculations", "molecular", - "one", - "nm", - "directly", - "entirely", - "proteins", "models", + "design", + "require", + "role", + "however", + "one", "specificity", - "common", - "performed", - "low", - "micromolar", + "energy", + "tuned", + "laborious", "de", - "novo", "ranging", - "energies", - "calculations", - "screening", - "laborious", - "poly", - "computation", - "optimization", - "typically", - "designed", - "seen", - "different", - "small", - "confirmed", - "affinities", + "structures", + "progress", "agreement", - "recognizes", - "simulations", + "computation", "experimentally", + "different", + "performed", + "three", + "free", "pharmacophore", - "crystal", - "feasible", - "informed", - "tuned", - "design", - "procedure", - "dynamics", - "measured", - "structures", - "protein", - "bound", + "nm", + "seen", "interactions", - "progress", - "recent", - "water", - "three", - "energy", - "computational", + "protein", + "optimization", "inhibitors", - "tunable", - "however", - "role", - "free", + "5", + "bound", + "proteins", + "feasible", "binding", + "low", + "accuracy", + "poly", + "measured", + "interaction", + "series", + "confirmed", + "novo", + "dynamics", + "entirely", + "energies", + "tunable", + "small", + "common", + "recognizes", + "informed", + "excellent", "developed", - "interaction" + "recent", + "procedure", + "crystal", + "screening", + "affinities", + "micromolar", + "computational", + "conclude", + "exciting", + "directly", + "water" ], "release_date":"2024-04-24", "publication":"\"De novo design of drug-binding proteins with predictable binding energy and specificity\", Science, 384, 106-112", @@ -869466,14 +873081,14 @@ "sim":0.9846000075, "partner":"8tnb" }, - { - "sim":0.9824000001, - "partner":"8tnc" - }, { "sim":0.9909999967, "partner":"8tnd" }, + { + "sim":0.9824000001, + "partner":"8tnc" + }, { "sim":0.9959999919, "partner":"8tn6" @@ -869582,80 +873197,80 @@ ], "subtitle":"De novo designed protein binds poly adp ribose polymerase inhibitors (parpi) - holo rucaparib", "tags":[ - "4-helix bundle", - "drug binding", - "de novo protein", + "de novo design", "parpi", - "de novo design" + "de novo protein", + "4-helix bundle", + "drug binding" ], "keywords":[ - "series", - "accuracy", - "conclude", - "exciting", - "5", - "require", - "excellent", + "designed", + "simulations", + "typically", + "calculations", "molecular", - "one", - "nm", - "directly", - "entirely", - "proteins", "models", + "design", + "require", + "role", + "however", + "one", "specificity", - "common", - "performed", - "low", - "micromolar", + "energy", + "tuned", + "laborious", "de", - "novo", "ranging", - "energies", - "calculations", - "screening", - "laborious", - "poly", - "computation", - "optimization", - "typically", - "designed", - "seen", - "different", - "small", - "confirmed", - "affinities", + "structures", + "progress", "agreement", - "recognizes", - "simulations", + "computation", "experimentally", + "different", + "performed", + "three", + "free", "pharmacophore", - "crystal", - "feasible", - "informed", - "tuned", - "design", - "procedure", - "dynamics", - "measured", - "structures", - "protein", - "bound", + "nm", + "seen", "interactions", - "progress", - "recent", - "water", - "three", - "energy", - "computational", + "protein", + "optimization", "inhibitors", - "tunable", - "however", - "role", - "free", + "5", + "bound", + "proteins", + "feasible", "binding", + "low", + "accuracy", + "poly", + "measured", + "interaction", + "series", + "confirmed", + "novo", + "dynamics", + "entirely", + "energies", + "tunable", + "small", + "common", + "recognizes", + "informed", + "excellent", "developed", - "interaction" + "recent", + "procedure", + "crystal", + "screening", + "affinities", + "micromolar", + "computational", + "conclude", + "exciting", + "directly", + "water" ], "release_date":"2024-04-24", "publication":"\"De novo design of drug-binding proteins with predictable binding energy and specificity\", Science, 384, 106-112", @@ -869715,13 +873330,13 @@ "sim":0.9908000231, "partner":"8tnd" }, - { - "sim":0.9966999888, - "partner":"8tn1" - }, { "sim":0.9811000228, "partner":"8tnc" + }, + { + "sim":0.9966999888, + "partner":"8tn1" } ], "struct_thr_sim_natural":[ @@ -869827,81 +873442,81 @@ ], "subtitle":"De novo designed protein binds poly adp ribose polymerase inhibitors (parpi) - holo mefuparib", "tags":[ - "4-helix bundle", - "drug binding", - "de novo protein", - "parpi", + "de novo design", "mefuparib", - "de novo design" + "parpi", + "de novo protein", + "4-helix bundle", + "drug binding" ], "keywords":[ - "series", - "accuracy", - "conclude", - "exciting", - "5", - "require", - "excellent", + "designed", + "simulations", + "typically", + "calculations", "molecular", - "one", - "nm", - "directly", - "entirely", - "proteins", "models", + "design", + "require", + "role", + "however", + "one", "specificity", - "common", - "performed", - "low", - "micromolar", + "energy", + "tuned", + "laborious", "de", - "novo", "ranging", - "energies", - "calculations", - "screening", - "laborious", - "poly", - "computation", - "optimization", - "typically", - "designed", - "seen", - "different", - "small", - "confirmed", - "affinities", + "structures", + "progress", "agreement", - "recognizes", - "simulations", + "computation", "experimentally", + "different", + "performed", + "three", + "free", "pharmacophore", - "crystal", - "feasible", - "informed", - "tuned", - "design", - "procedure", - "dynamics", - "measured", - "structures", - "protein", - "bound", + "nm", + "seen", "interactions", - "progress", - "recent", - "water", - "three", - "energy", - "computational", + "protein", + "optimization", "inhibitors", - "tunable", - "however", - "role", - "free", + "5", + "bound", + "proteins", + "feasible", "binding", + "low", + "accuracy", + "poly", + "measured", + "interaction", + "series", + "confirmed", + "novo", + "dynamics", + "entirely", + "energies", + "tunable", + "small", + "common", + "recognizes", + "informed", + "excellent", "developed", - "interaction" + "recent", + "procedure", + "crystal", + "screening", + "affinities", + "micromolar", + "computational", + "conclude", + "exciting", + "directly", + "water" ], "release_date":"2024-04-24", "publication":"\"De novo design of drug-binding proteins with predictable binding energy and specificity\", Science, 384, 106-112", @@ -869938,11 +873553,11 @@ }, { "sim":273.0, - "partner":"8tn1" + "partner":"8tn6" }, { "sim":273.0, - "partner":"8tn6" + "partner":"8tn1" }, { "sim":273.0, @@ -869953,10 +873568,6 @@ ], "struct_thr_sim_designed":[ - { - "sim":0.9965999722, - "partner":"8tn6" - }, { "sim":0.9930999875, "partner":"8tnd" @@ -869965,6 +873576,10 @@ "sim":0.9840000272, "partner":"8tn1" }, + { + "sim":0.9965999722, + "partner":"8tn6" + }, { "sim":0.9850000143, "partner":"8tnc" @@ -870073,80 +873688,80 @@ ], "subtitle":"De novo designed protein binds poly adp ribose polymerase inhibitors (parpi) - holo niraparib", "tags":[ - "4-helix bundle", - "drug binding", - "de novo protein", + "de novo design", "parpi", - "de novo design" + "de novo protein", + "4-helix bundle", + "drug binding" ], "keywords":[ - "series", - "accuracy", - "conclude", - "exciting", - "5", - "require", - "excellent", + "designed", + "simulations", + "typically", + "calculations", "molecular", - "one", - "nm", - "directly", - "entirely", - "proteins", "models", + "design", + "require", + "role", + "however", + "one", "specificity", - "common", - "performed", - "low", - "micromolar", + "energy", + "tuned", + "laborious", "de", - "novo", "ranging", - "energies", - "calculations", - "screening", - "laborious", - "poly", - "computation", - "optimization", - "typically", - "designed", - "seen", - "different", - "small", - "confirmed", - "affinities", + "structures", + "progress", "agreement", - "recognizes", - "simulations", + "computation", "experimentally", + "different", + "performed", + "three", + "free", "pharmacophore", - "crystal", - "feasible", - "informed", - "tuned", - "design", - "procedure", - "dynamics", - "measured", - "structures", - "protein", - "bound", + "nm", + "seen", "interactions", - "progress", - "recent", - "water", - "three", - "energy", - "computational", + "protein", + "optimization", "inhibitors", - "tunable", - "however", - "role", - "free", + "5", + "bound", + "proteins", + "feasible", "binding", + "low", + "accuracy", + "poly", + "measured", + "interaction", + "series", + "confirmed", + "novo", + "dynamics", + "entirely", + "energies", + "tunable", + "small", + "common", + "recognizes", + "informed", + "excellent", "developed", - "interaction" + "recent", + "procedure", + "crystal", + "screening", + "affinities", + "micromolar", + "computational", + "conclude", + "exciting", + "directly", + "water" ], "release_date":"2024-04-24", "publication":"\"De novo design of drug-binding proteins with predictable binding energy and specificity\", Science, 384, 106-112", @@ -870187,21 +873802,17 @@ }, { "sim":273.0, - "partner":"8tn1" + "partner":"8tn6" }, { "sim":273.0, - "partner":"8tn6" + "partner":"8tn1" } ], "seq_thr_sim_natural":[ ], "struct_thr_sim_designed":[ - { - "sim":0.9847999811, - "partner":"8tn6" - }, { "sim":0.9890000224, "partner":"8tnd" @@ -870210,6 +873821,10 @@ "sim":0.9887999892, "partner":"8tnb" }, + { + "sim":0.9847999811, + "partner":"8tn6" + }, { "sim":0.9847999811, "partner":"8tn1" @@ -870318,81 +873933,81 @@ ], "subtitle":"De novo designed protein binds poly adp ribose polymerase inhibitors (parpi) - holo veliparib", "tags":[ - "4-helix bundle", - "veliparib", - "drug binding", - "de novo protein", + "de novo design", "parpi", - "de novo design" + "de novo protein", + "veliparib", + "4-helix bundle", + "drug binding" ], "keywords":[ - "series", - "accuracy", - "conclude", - "exciting", - "5", - "require", - "excellent", + "designed", + "simulations", + "typically", + "calculations", "molecular", - "one", - "nm", - "directly", - "entirely", - "proteins", "models", + "design", + "require", + "role", + "however", + "one", "specificity", - "common", - "performed", - "low", - "micromolar", + "energy", + "tuned", + "laborious", "de", - "novo", "ranging", - "energies", - "calculations", - "screening", - "laborious", - "poly", - "computation", - "optimization", - "typically", - "designed", - "seen", - "different", - "small", - "confirmed", - "affinities", + "structures", + "progress", "agreement", - "recognizes", - "simulations", + "computation", "experimentally", + "different", + "performed", + "three", + "free", "pharmacophore", - "crystal", - "feasible", - "informed", - "tuned", - "design", - "procedure", - "dynamics", - "measured", - "structures", - "protein", - "bound", + "nm", + "seen", "interactions", - "progress", - "recent", - "water", - "three", - "energy", - "computational", + "protein", + "optimization", "inhibitors", - "tunable", - "however", - "role", - "free", + "5", + "bound", + "proteins", + "feasible", "binding", + "low", + "accuracy", + "poly", + "measured", + "interaction", + "series", + "confirmed", + "novo", + "dynamics", + "entirely", + "energies", + "tunable", + "small", + "common", + "recognizes", + "informed", + "excellent", "developed", - "interaction" + "recent", + "procedure", + "crystal", + "screening", + "affinities", + "micromolar", + "computational", + "conclude", + "exciting", + "directly", + "water" ], "release_date":"2024-04-24", "publication":"\"De novo design of drug-binding proteins with predictable binding energy and specificity\", Science, 384, 106-112", @@ -870429,11 +874044,11 @@ }, { "sim":273.0, - "partner":"8tn1" + "partner":"8tn6" }, { "sim":273.0, - "partner":"8tn6" + "partner":"8tn1" }, { "sim":273.0, @@ -870615,117 +874230,117 @@ "chroma" ], "keywords":[ - "evolution", - "constraints", - "results", - "accessing", - "architecture", + "molecular", + "scaling", + "experimental", "complexes", - "expressed", - "designed", - "geometries", - "polymer", - "achieves", - "towards", - "crystal", - "potential", - "sampling", - "sequences", - "synthetic", - "diversity", - "bayesian", - "health", - "involve", - "novel", - "algorithm", - "even", + "computation", + "around", + "matter", + "three", + "deviation", + "results", + "model", + "protein", + "hope", + "neural", + "layers", + "produced", "general", - "symmetries", + "greater", + "systems", + "two", + "generative", + "crystal", + "conditioned", + "chroma", + "enables", + "shows", + "conformational", + "substructure", + "agreement", + "functions", + "reasoning", + "favourable", "semantics", + "approach", "proteins", - "models", - "larger", - "substructure", - "enables", - "310", "process", - "\u00e5", - "efficient", + "characterization", + "architecture", + "constraints", + "inference", "highly", - "materials", - "generative", - "atomistic", - "structures", - "three", - "reasoning", - "likely", - "biology", - "exhibit", - "layers", - "shows", - "molecules", - "systems", - "much", + "external", + "benefit", + "larger", + "evolution", + "1", + "science", + "geometries", "unified", - "inference", + "polymer", + "challenging", + "sampling", + "design", + "exhibit", + "ensembles", + "even", + "biology", + "possible", + "health", + "potential", "properties", + "samples", + "fold", + "diversity", + "experiments", + "algorithm", + "billion", + "backbone", + "predicted", + "involve", + "full", "accelerate", - "years", - "molecular", + "materials", + "desired", "directly", - "chroma", - "programming", - "billion", - "1", - "shape", - "challenging", - "functions", - "agreement", + "designed", + "models", + "sequences", + "efficient", + "space", + "tremendous", + "structures", "statistics", - "matter", + "expressed", "respects", - "design", - "produced", - "model", - "characterization", + "symmetries", + "accessing", + "\u00e5", + "likely", + "efficiently", + "synthetic", "introduce", - "steer", - "diffusion", - "neural", - "favourable", - "greater", - "hope", - "tremendous", - "around", + "shape", + "biophysical", + "programming", + "molecules", + "prompts", + "enable", + "310", + "towards", + "much", "synthesizing", - "predicted", + "years", "sample", - "efficiently", - "conformational", - "approach", - "prompts", - "experiments", - "desired", - "computation", - "experimental", - "fold", + "bayesian", + "diffusion", + "steer", "human", - "enable", - "deviation", - "samples", - "benefit", - "external", - "science", - "two", - "protein", - "full", - "backbone", - "space", - "scaling", - "conditioned", - "ensembles", - "possible", - "biophysical" + "achieves", + "atomistic", + "novel" ], "release_date":"2023-11-22", "publication":"\"Illuminating protein space with a programmable generative model\", Nature, 623, 1070-1078", @@ -870917,117 +874532,117 @@ "chroma" ], "keywords":[ - "evolution", - "constraints", - "results", - "accessing", - "architecture", + "molecular", + "scaling", + "experimental", "complexes", - "expressed", - "designed", - "geometries", - "polymer", - "achieves", - "towards", - "crystal", - "potential", - "sampling", - "sequences", - "synthetic", - "diversity", - "bayesian", - "health", - "involve", - "novel", - "algorithm", - "even", + "computation", + "around", + "matter", + "three", + "deviation", + "results", + "model", + "protein", + "hope", + "neural", + "layers", + "produced", "general", - "symmetries", + "greater", + "systems", + "two", + "generative", + "crystal", + "conditioned", + "chroma", + "enables", + "shows", + "conformational", + "substructure", + "agreement", + "functions", + "reasoning", + "favourable", "semantics", + "approach", "proteins", - "models", - "larger", - "substructure", - "enables", - "310", "process", - "\u00e5", - "efficient", + "characterization", + "architecture", + "constraints", + "inference", "highly", - "materials", - "generative", - "atomistic", - "structures", - "three", - "reasoning", - "likely", - "biology", - "exhibit", - "layers", - "shows", - "molecules", - "systems", - "much", + "external", + "benefit", + "larger", + "evolution", + "1", + "science", + "geometries", "unified", - "inference", + "polymer", + "challenging", + "sampling", + "design", + "exhibit", + "ensembles", + "even", + "biology", + "possible", + "health", + "potential", "properties", + "samples", + "fold", + "diversity", + "experiments", + "algorithm", + "billion", + "backbone", + "predicted", + "involve", + "full", "accelerate", - "years", - "molecular", + "materials", + "desired", "directly", - "chroma", - "programming", - "billion", - "1", - "shape", - "challenging", - "functions", - "agreement", + "designed", + "models", + "sequences", + "efficient", + "space", + "tremendous", + "structures", "statistics", - "matter", + "expressed", "respects", - "design", - "produced", - "model", - "characterization", + "symmetries", + "accessing", + "\u00e5", + "likely", + "efficiently", + "synthetic", "introduce", - "steer", - "diffusion", - "neural", - "favourable", - "greater", - "hope", - "tremendous", - "around", + "shape", + "biophysical", + "programming", + "molecules", + "prompts", + "enable", + "310", + "towards", + "much", "synthesizing", - "predicted", + "years", "sample", - "efficiently", - "conformational", - "approach", - "prompts", - "experiments", - "desired", - "computation", - "experimental", - "fold", + "bayesian", + "diffusion", + "steer", "human", - "enable", - "deviation", - "samples", - "benefit", - "external", - "science", - "two", - "protein", - "full", - "backbone", - "space", - "scaling", - "conditioned", - "ensembles", - "possible", - "biophysical" + "achieves", + "atomistic", + "novel" ], "release_date":"2023-11-22", "publication":"\"Illuminating protein space with a programmable generative model\", Nature, 623, 1070-1078", @@ -871149,113 +874764,113 @@ ], "keywords":[ "largely", - "\u03b2", + "anchored", + "minimum", + "learning", + "intrinsically", + "around", + "observable", + "canonical", "results", - "restricted", - "peptide", - "designed", + "new", + "machine", + "folding", + "residue", + "model", + "nonredundant", "physicochemical", - "example", - "broad", - "current", - "potential", - "features", - "based", - "sequences", + "protein", + "study", + "network", + "31", + "neural", + "biomedical", "\u03b1", - "expand", - "generates", - "structure", + "essential", + "novo", + "generative", "establish", - "fields", + "secondary", + "using", + "deep", + "conformational", + "limits", + "volume", + "synthesize", + "respectively", + "biological", + "50", + "helix", + "preliminary", "intended", - "distinguishes", - "ncbi", - "hydrophobicity", - "nonredundant", - "biomedical", - "network", - "models", + "derived", + "20", + "approach", "proteins", - "unique", - "specifically", - "de", - "beyond", - "volume", + "accuracy", + "broad", "universe", - "evolutionary", - "generative", + "created", + "features", + "restricted", + "identities", + "peptide", + "lack", + "property", + "pdb", + "robustly", "highlight", - "structures", - "derived", - "foundation", - "essential", "theoretical", - "disordered", - "minimum", - "compared", - "intrinsically", - "created", - "properties", - "data", - "homology", - "amino", - "31", - "respectively", - "synthesize", - "adversarial", - "artificial", - "anchored", - "acids", - "frontier", - "limits", - "landscape", - "canonical", - "application", "design", - "model", - "using", + "beta", "context", - "secondary", - "existing", - "96", - "promising", - "neural", - "sequence", - "biological", - "property", + "compared", + "current", "extant", - "learning", - "around", - "machine", - "accuracy", - "pdb", - "identities", - "robustly", + "potential", "tested", - "conformational", - "lack", - "approach", - "study", - "novo", - "way", + "application", + "properties", "fold", - "peptides", - "observable", + "beyond", + "disordered", + "hydrophobicity", + "amino", + "foundation", + "generates", "databases", + "promising", + "sequence", + "peptides", + "expand", + "landscape", + "frontier", + "unique", + "96", + "ncbi", + "evolutionary", + "evolutionarily", + "designed", + "example", + "models", + "sequences", + "way", "custom", - "50", - "protein", - "residue", - "helix", - "preliminary", - "beta", + "structures", + "de", + "based", "hairpin", - "20", - "deep", - "folding", - "evolutionarily", - "new" + "\u03b2", + "specifically", + "structure", + "distinguishes", + "fields", + "adversarial", + "artificial", + "acids", + "existing", + "data", + "homology" ], "release_date":"2023-09-06", "publication":"\"Generative beta-hairpin design using a residue-based physicochemical property landscape\", Biophys.J., 123, 2790-2806", @@ -871352,8 +874967,8 @@ ], "subtitle":"De novo design of near infrared fluorescent proteins", "tags":[ - "de novo protein", "fluorescent proteins", + "de novo protein", "de novo design", "near infrared" ], @@ -871475,8 +875090,8 @@ ], "subtitle":"C-terminal lrrk2 bound to e11 darpin", "tags":[ - "complex", "protein binding", + "complex", "darpins", "kinase" ], @@ -871547,27 +875162,27 @@ }, { "sim":274.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":274.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":273.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":273.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":273.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":273.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":273.0, @@ -871575,35 +875190,35 @@ }, { "sim":273.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":273.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":273.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":273.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":273.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":273.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":273.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":273.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":271.0, @@ -871715,7 +875330,7 @@ }, { "sim":252.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":252.0, @@ -871723,7 +875338,7 @@ }, { "sim":252.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":251.0, @@ -871783,11 +875398,11 @@ }, { "sim":228.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":228.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":228.0, @@ -871803,11 +875418,11 @@ }, { "sim":208.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":208.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":207.0, @@ -871833,6 +875448,10 @@ "sim":192.0, "partner":"9f23" }, + { + "sim":190.0, + "partner":"9glq" + }, { "sim":184.0, "partner":"8aiw" @@ -871883,10 +875502,6 @@ } ], "seq_thr_sim_natural":[ - { - "sim":376.0, - "partner":"8tzb" - }, { "sim":376.0, "partner":"8tzc" @@ -871903,6 +875518,10 @@ "sim":376.0, "partner":"8tzh" }, + { + "sim":376.0, + "partner":"8tzb" + }, { "sim":328.0, "partner":"6fp8" @@ -871981,87 +875600,87 @@ }, { "sim":273.0, - "partner":"7yz0" + "partner":"6mzf" }, { "sim":273.0, - "partner":"5oyj" + "partner":"6mze" }, { "sim":273.0, - "partner":"6mzf" + "partner":"5nqt" }, { "sim":273.0, - "partner":"7yz1" + "partner":"7yz2" }, { "sim":273.0, - "partner":"7z01" + "partner":"7z02" }, { "sim":273.0, - "partner":"5nqt" + "partner":"7ac5" }, { "sim":273.0, - "partner":"6mze" + "partner":"5nqu" }, { "sim":273.0, - "partner":"7yz2" + "partner":"7yz3" }, { "sim":273.0, - "partner":"7z02" + "partner":"7yz5" }, { "sim":273.0, - "partner":"5nqu" + "partner":"7yz6" }, { "sim":273.0, - "partner":"7ac5" + "partner":"4lnu" }, { "sim":273.0, - "partner":"7yz3" + "partner":"6zwb" }, { "sim":273.0, - "partner":"7yz5" + "partner":"4drx" }, { "sim":273.0, - "partner":"4lnu" + "partner":"5nm5" }, { "sim":273.0, - "partner":"7yz6" + "partner":"6zwc" }, { "sim":273.0, - "partner":"4drx" + "partner":"7yyy" }, { "sim":273.0, - "partner":"5nm5" + "partner":"7yyz" }, { "sim":273.0, - "partner":"6zwb" + "partner":"7yz0" }, { "sim":273.0, - "partner":"6zwc" + "partner":"5oyj" }, { "sim":273.0, - "partner":"7yyy" + "partner":"7yz1" }, { "sim":273.0, - "partner":"7yyz" + "partner":"7z01" }, { "sim":273.0, @@ -872091,45 +875710,25 @@ "sim":270.0, "partner":"4jb8" }, - { - "sim":269.0, - "partner":"5eno" - }, - { - "sim":269.0, - "partner":"6zob" - }, - { - "sim":269.0, - "partner":"6zo5" - }, { "sim":269.0, "partner":"4dx6" }, { "sim":269.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":269.0, "partner":"6zoc" }, - { - "sim":269.0, - "partner":"5enp" - }, - { - "sim":269.0, - "partner":"6sgs" - }, { "sim":269.0, "partner":"6zo6" }, { "sim":269.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":269.0, @@ -872137,7 +875736,7 @@ }, { "sim":269.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":269.0, @@ -872145,11 +875744,11 @@ }, { "sim":269.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":269.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":269.0, @@ -872159,6 +875758,10 @@ "sim":269.0, "partner":"6zoe" }, + { + "sim":269.0, + "partner":"5enq" + }, { "sim":269.0, "partner":"6q4p" @@ -872169,19 +875772,19 @@ }, { "sim":269.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":269.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":269.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":269.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":269.0, @@ -872193,23 +875796,23 @@ }, { "sim":269.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":269.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":269.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":269.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":269.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":269.0, @@ -872221,15 +875824,15 @@ }, { "sim":269.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":269.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":269.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":269.0, @@ -872237,15 +875840,19 @@ }, { "sim":269.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":269.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":269.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":269.0, + "partner":"6sgr" }, { "sim":269.0, @@ -872261,12 +875868,24 @@ }, { "sim":269.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":269.0, "partner":"4dx5" }, + { + "sim":269.0, + "partner":"5eno" + }, + { + "sim":269.0, + "partner":"6zo5" + }, + { + "sim":269.0, + "partner":"6q4n" + }, { "sim":269.0, "partner":"5aq9" @@ -872305,11 +875924,11 @@ }, { "sim":267.0, - "partner":"4f6r" + "partner":"6gvn" }, { "sim":267.0, - "partner":"6gvn" + "partner":"4f6r" }, { "sim":267.0, @@ -872317,11 +875936,11 @@ }, { "sim":267.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":267.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":267.0, @@ -872409,11 +876028,11 @@ }, { "sim":256.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":256.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":256.0, @@ -872445,11 +876064,11 @@ }, { "sim":251.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":251.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":251.0, @@ -872483,10 +876102,6 @@ "sim":248.0, "partner":"4hll" }, - { - "sim":246.0, - "partner":"7pd8" - }, { "sim":246.0, "partner":"7pdd" @@ -872499,6 +876114,10 @@ "sim":246.0, "partner":"7pdh" }, + { + "sim":246.0, + "partner":"7pd8" + }, { "sim":246.0, "partner":"6ar6" @@ -872517,11 +876136,11 @@ }, { "sim":244.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":244.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":244.0, @@ -872623,10 +876242,6 @@ "sim":228.0, "partner":"5gik" }, - { - "sim":228.0, - "partner":"8g4f" - }, { "sim":228.0, "partner":"8g42" @@ -872643,17 +876258,21 @@ "sim":228.0, "partner":"8g3k" }, + { + "sim":228.0, + "partner":"8g4f" + }, { "sim":224.0, "partner":"6moi" }, { "sim":221.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":221.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":220.0, @@ -872777,23 +876396,23 @@ }, { "sim":127.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":127.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":127.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":127.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":127.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":127.0, @@ -872801,11 +876420,11 @@ }, { "sim":127.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":127.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":127.0, @@ -872891,10 +876510,6 @@ "sim":114.0, "partner":"5y4f" }, - { - "sim":113.0, - "partner":"5vhj" - }, { "sim":113.0, "partner":"5vhh" @@ -872925,15 +876540,15 @@ }, { "sim":113.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":113.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":113.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":113.0, @@ -872943,6 +876558,10 @@ "sim":113.0, "partner":"7vxw" }, + { + "sim":113.0, + "partner":"1uoh" + }, { "sim":113.0, "partner":"7vy4" @@ -872953,11 +876572,11 @@ }, { "sim":113.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":113.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":113.0, @@ -872969,15 +876588,15 @@ }, { "sim":113.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":113.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":113.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":113.0, @@ -873061,11 +876680,11 @@ }, { "sim":99.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":99.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":98.0, @@ -873073,16 +876692,24 @@ }, { "sim":98.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":98.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":98.0, "partner":"7roy" }, + { + "sim":98.0, + "partner":"8wqg" + }, + { + "sim":98.0, + "partner":"8wqe" + }, { "sim":98.0, "partner":"8wqh" @@ -873111,14 +876738,6 @@ "sim":98.0, "partner":"8wqd" }, - { - "sim":98.0, - "partner":"8wqg" - }, - { - "sim":98.0, - "partner":"8wqe" - }, { "sim":98.0, "partner":"8je1" @@ -873249,11 +876868,11 @@ }, { "sim":91.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":91.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":91.0, @@ -873321,19 +876940,19 @@ }, { "sim":89.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":89.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":89.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":89.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":89.0, @@ -873479,10 +877098,6 @@ "sim":82.0, "partner":"6v9h" }, - { - "sim":82.0, - "partner":"6v9x" - }, { "sim":82.0, "partner":"6v9y" @@ -873495,6 +877110,10 @@ "sim":82.0, "partner":"6v9w" }, + { + "sim":82.0, + "partner":"6v9x" + }, { "sim":82.0, "partner":"7or0" @@ -873587,14 +877206,6 @@ "sim":77.0, "partner":"7xc5" }, - { - "sim":76.0, - "partner":"6m11" - }, - { - "sim":76.0, - "partner":"6m12" - }, { "sim":76.0, "partner":"6m13" @@ -873620,12 +877231,16 @@ "partner":"4o1p" }, { - "sim":75.0, - "partner":"1ymp" + "sim":76.0, + "partner":"6m11" + }, + { + "sim":76.0, + "partner":"6m12" }, { "sim":75.0, - "partner":"2a5e" + "partner":"1ymp" }, { "sim":75.0, @@ -873635,6 +877250,10 @@ "sim":75.0, "partner":"1a5e" }, + { + "sim":75.0, + "partner":"2a5e" + }, { "sim":75.0, "partner":"4ot9" @@ -873649,11 +877268,11 @@ }, { "sim":74.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":74.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":74.0, @@ -873755,10 +877374,6 @@ "sim":66.0, "partner":"5wo6" }, - { - "sim":66.0, - "partner":"5iwr" - }, { "sim":66.0, "partner":"5iwt" @@ -873813,11 +877428,11 @@ }, { "sim":66.0, - "partner":"5wo7" + "partner":"5iwr" }, { - "sim":65.0, - "partner":"6o1p" + "sim":66.0, + "partner":"5wo7" }, { "sim":65.0, @@ -873857,11 +877472,7 @@ }, { "sim":65.0, - "partner":"7t6m" - }, - { - "sim":65.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":65.0, @@ -873897,15 +877508,19 @@ }, { "sim":65.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":65.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":65.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":65.0, + "partner":"7t6k" }, { "sim":65.0, @@ -873913,7 +877528,7 @@ }, { "sim":65.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":65.0, @@ -873921,7 +877536,11 @@ }, { "sim":65.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":65.0, + "partner":"8ffn" }, { "sim":64.0, @@ -873989,11 +877608,11 @@ }, { "sim":60.0, - "partner":"7ttr" + "partner":"7tts" }, { "sim":60.0, - "partner":"7tts" + "partner":"7ttr" }, { "sim":59.0, @@ -874043,10 +877662,6 @@ "sim":59.0, "partner":"8sp8" }, - { - "sim":59.0, - "partner":"7k4a" - }, { "sim":59.0, "partner":"7k4b" @@ -874069,7 +877684,7 @@ }, { "sim":59.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":59.0, @@ -874085,7 +877700,7 @@ }, { "sim":59.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":59.0, @@ -874097,7 +877712,7 @@ }, { "sim":59.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":59.0, @@ -874115,6 +877730,10 @@ "sim":59.0, "partner":"6bo8" }, + { + "sim":59.0, + "partner":"6bo9" + }, { "sim":58.0, "partner":"6jmt" @@ -874143,6 +877762,10 @@ "sim":51.0, "partner":"8szl" }, + { + "sim":51.0, + "partner":"8ycp" + }, { "sim":51.0, "partner":"8gf8" @@ -874176,7 +877799,7 @@ }, "seq_max_sim_natural":{ "sim":376.0, - "partner":"8tzb" + "partner":"8tzc" }, "struct_max_sim_designed":{ "sim":0.8568000197, @@ -874279,11 +877902,11 @@ "subtitle":"Crystal structure of the fis1 cytosolic domain bound to a peptide inhibitor", "tags":[ "peptide binding protein\/inhibitor", - "inhibitor", "mitochondria", - "fission", + "inhibitor", "peptide binding protein-inhibitor complex", - "tetracopipeptide repeat protein" + "tetracopipeptide repeat protein", + "fission" ], "keywords":[ "description", @@ -874434,89 +878057,89 @@ ], "subtitle":"Improving protein expression, stability, and function with proteinmpnn", "tags":[ - "stability", + "protein expression", "function", - "proteinmpnn", + "stability", + "de novo design", "de novo protein", - "protein expression", - "de novo design" + "proteinmpnn" ], "keywords":[ - "heterologous", - "stability", - "general", - "solubility", - "parent", - "reported", - "maintaining", - "designs", - "poor", - "network", - "proteins", - "proteinmpnn", - "virus", - "thus", - "optimized", - "multiple", - "approach", - "technologies", - "route", - "wide", - "produce", - "improves", - "temperature", - "catalytic", - "increasing", - "variants", - "tev", - "method", - "together", - "information", - "temperatures", - "etch", - "generated", - "highly", - "useful", + "biotechnological", "protease", - "difficult", - "activity", - "due", - "improved", - "sensitivity", - "identified", - "evolutionary", + "technologies", "often", - "improving", "limited", - "provides", - "biotechnologically", + "tobacco", + "optimized", + "structural", + "compared", + "scale", "show", - "melting", + "variants", + "provides", + "improving", + "suitable", + "natural", + "due", + "evolutionary", + "information", + "improves", + "produce", + "multiple", "previously", - "expression", - "scale", + "thus", + "identified", + "properties", + "sensitivity", + "route", + "solubility", + "important", + "virus", + "biotechnologically", + "could", + "temperature", + "network", "protein", - "applications", - "natural", + "heterologous", "myoglobin", - "neural", + "useful", "function", - "suitable", - "biotechnological", + "wide", + "stability", + "melting", + "approach", + "proteins", + "neural", + "improved", + "utility", + "together", + "poor", + "general", + "activity", "native", - "elevated", - "physical", - "sequence", "broadly", - "could", - "compared", - "deep", - "tobacco", + "highly", + "sequence", + "reported", "systems", - "structural", - "important", - "utility", - "properties" + "difficult", + "tev", + "expression", + "generated", + "elevated", + "catalytic", + "parent", + "etch", + "applications", + "physical", + "temperatures", + "designs", + "method", + "increasing", + "proteinmpnn", + "maintaining", + "deep" ], "release_date":"2024-01-17", "publication":"\"Improving Protein Expression, Stability, and Function with ProteinMPNN\", J.Am.Chem.Soc., 146, 2054-2061", @@ -874582,10 +878205,6 @@ "sim":106.0, "partner":"6g5t" }, - { - "sim":104.0, - "partner":"5ojc" - }, { "sim":104.0, "partner":"5oja" @@ -874595,48 +878214,8 @@ "partner":"5ojb" }, { - "sim":99.0, - "partner":"1mbo" - }, - { - "sim":99.0, - "partner":"1yoh" - }, - { - "sim":99.0, - "partner":"2mya" - }, - { - "sim":99.0, - "partner":"4mbn" - }, - { - "sim":99.0, - "partner":"1yoi" - }, - { - "sim":99.0, - "partner":"2ekt" - }, - { - "sim":99.0, - "partner":"2mb5" - }, - { - "sim":99.0, - "partner":"2myb" - }, - { - "sim":99.0, - "partner":"1jpb" - }, - { - "sim":99.0, - "partner":"2eku" - }, - { - "sim":99.0, - "partner":"2myc" + "sim":104.0, + "partner":"5ojc" }, { "sim":99.0, @@ -874664,19 +878243,19 @@ }, { "sim":99.0, - "partner":"1vxa" + "partner":"1jpb" }, { "sim":99.0, - "partner":"2zso" + "partner":"1vxa" }, { "sim":99.0, - "partner":"2zsz" + "partner":"2zso" }, { "sim":99.0, - "partner":"1iop" + "partner":"2zsz" }, { "sim":99.0, @@ -874722,6 +878301,10 @@ "sim":99.0, "partner":"3ed9" }, + { + "sim":99.0, + "partner":"1iop" + }, { "sim":99.0, "partner":"1u7r" @@ -874770,10 +878353,6 @@ "sim":99.0, "partner":"3edb" }, - { - "sim":99.0, - "partner":"1f6h" - }, { "sim":99.0, "partner":"1vxg" @@ -874782,14 +878361,6 @@ "sim":99.0, "partner":"3ecx" }, - { - "sim":99.0, - "partner":"1bzp" - }, - { - "sim":99.0, - "partner":"1duk" - }, { "sim":99.0, "partner":"1l2k" @@ -874798,10 +878369,6 @@ "sim":99.0, "partner":"1vxh" }, - { - "sim":99.0, - "partner":"1ebc" - }, { "sim":99.0, "partner":"3e4n" @@ -874812,7 +878379,7 @@ }, { "sim":99.0, - "partner":"1ajg" + "partner":"1f6h" }, { "sim":99.0, @@ -874820,11 +878387,11 @@ }, { "sim":99.0, - "partner":"1ajh" + "partner":"1bzp" }, { "sim":99.0, - "partner":"1bvc" + "partner":"1duk" }, { "sim":99.0, @@ -874832,7 +878399,7 @@ }, { "sim":99.0, - "partner":"1bvd" + "partner":"1ebc" }, { "sim":99.0, @@ -874840,7 +878407,7 @@ }, { "sim":99.0, - "partner":"104m" + "partner":"1ajg" }, { "sim":99.0, @@ -874852,11 +878419,19 @@ }, { "sim":99.0, - "partner":"1bz6" + "partner":"1ajh" }, { "sim":99.0, - "partner":"1bzr" + "partner":"1bvc" + }, + { + "sim":99.0, + "partner":"1bvd" + }, + { + "sim":99.0, + "partner":"104m" }, { "sim":99.0, @@ -874868,7 +878443,7 @@ }, { "sim":99.0, - "partner":"105m" + "partner":"1bz6" }, { "sim":99.0, @@ -874884,11 +878459,15 @@ }, { "sim":99.0, - "partner":"1hjt" + "partner":"1bzr" }, { "sim":99.0, - "partner":"1jp6" + "partner":"105m" + }, + { + "sim":99.0, + "partner":"1hjt" }, { "sim":99.0, @@ -874902,41 +878481,73 @@ "sim":99.0, "partner":"5mbn" }, + { + "sim":99.0, + "partner":"1jp6" + }, + { + "sim":99.0, + "partner":"1mbn" + }, + { + "sim":99.0, + "partner":"1yog" + }, { "sim":99.0, "partner":"1cq2" }, + { + "sim":99.0, + "partner":"1mbo" + }, + { + "sim":99.0, + "partner":"1yoh" + }, + { + "sim":99.0, + "partner":"2mya" + }, + { + "sim":99.0, + "partner":"4mbn" + }, { "sim":99.0, "partner":"1jp8" }, { "sim":99.0, - "partner":"1jp9" + "partner":"1yoi" }, { "sim":99.0, - "partner":"1mbn" + "partner":"2ekt" }, { "sim":99.0, - "partner":"1yog" + "partner":"2mb5" }, { "sim":99.0, - "partner":"5yce" + "partner":"2myb" }, { "sim":99.0, - "partner":"6n02" + "partner":"1jp9" }, { "sim":99.0, - "partner":"2jho" + "partner":"2eku" }, { "sim":99.0, - "partner":"6n03" + "partner":"2myc" + }, + { + "sim":99.0, + "partner":"2jho" }, { "sim":99.0, @@ -874979,44 +878590,44 @@ "partner":"6mv0" }, { - "sim":98.0, - "partner":"1a6k" + "sim":99.0, + "partner":"6n02" }, { - "sim":98.0, - "partner":"7vdn" + "sim":99.0, + "partner":"6n03" }, { - "sim":98.0, - "partner":"1a6m" + "sim":99.0, + "partner":"5yce" }, { "sim":98.0, - "partner":"1a6n" + "partner":"7vdn" }, { "sim":98.0, - "partner":"5xl0" + "partner":"1a6k" }, { "sim":98.0, - "partner":"5b85" + "partner":"1a6m" }, { "sim":98.0, - "partner":"4of9" + "partner":"1a6n" }, { "sim":98.0, - "partner":"6e03" + "partner":"5xl0" }, { "sim":98.0, - "partner":"6e04" + "partner":"4of9" }, { "sim":98.0, - "partner":"1tes" + "partner":"5b85" }, { "sim":98.0, @@ -875026,41 +878637,37 @@ "sim":98.0, "partner":"5yzf" }, - { - "sim":98.0, - "partner":"8fdj" - }, { "sim":98.0, "partner":"7a44" }, { "sim":98.0, - "partner":"109m" + "partner":"7a45" }, { "sim":98.0, - "partner":"7a45" + "partner":"5o41" }, { "sim":98.0, - "partner":"1abs" + "partner":"7ddr" }, { "sim":98.0, - "partner":"5o41" + "partner":"7dds" }, { "sim":98.0, - "partner":"1j3f" + "partner":"109m" }, { "sim":98.0, - "partner":"7ddr" + "partner":"1abs" }, { "sim":98.0, - "partner":"7dds" + "partner":"1j3f" }, { "sim":98.0, @@ -875080,15 +878687,15 @@ }, { "sim":98.0, - "partner":"110m" + "partner":"1mlo" }, { "sim":98.0, - "partner":"1mlo" + "partner":"2mgk" }, { "sim":98.0, - "partner":"2mgk" + "partner":"110m" }, { "sim":98.0, @@ -875100,11 +878707,11 @@ }, { "sim":98.0, - "partner":"111m" + "partner":"2mgm" }, { "sim":98.0, - "partner":"2mgm" + "partner":"6bmg" }, { "sim":98.0, @@ -875112,7 +878719,11 @@ }, { "sim":98.0, - "partner":"6bmg" + "partner":"111m" + }, + { + "sim":98.0, + "partner":"1v9q" }, { "sim":98.0, @@ -875120,35 +878731,39 @@ }, { "sim":98.0, - "partner":"112m" + "partner":"1ufj" }, { "sim":98.0, - "partner":"1j52" + "partner":"3ase" }, { "sim":98.0, - "partner":"1v9q" + "partner":"2ef2" }, { "sim":98.0, - "partner":"1ufj" + "partner":"2mbw" }, { "sim":98.0, - "partner":"3ase" + "partner":"5wjk" }, { "sim":98.0, - "partner":"2ef2" + "partner":"112m" }, { "sim":98.0, - "partner":"2mbw" + "partner":"1j52" }, { "sim":98.0, - "partner":"5wjk" + "partner":"4qau" + }, + { + "sim":98.0, + "partner":"6e02" }, { "sim":98.0, @@ -875156,7 +878771,7 @@ }, { "sim":98.0, - "partner":"4qau" + "partner":"6e03" }, { "sim":98.0, @@ -875164,19 +878779,19 @@ }, { "sim":98.0, - "partner":"6e02" + "partner":"6e04" }, { - "sim":97.0, - "partner":"5xkv" + "sim":98.0, + "partner":"1tes" }, { - "sim":97.0, - "partner":"2g12" + "sim":98.0, + "partner":"8fdj" }, { "sim":97.0, - "partner":"2g14" + "partner":"5xkv" }, { "sim":97.0, @@ -875194,10 +878809,6 @@ "sim":97.0, "partner":"1mlq" }, - { - "sim":97.0, - "partner":"1ch2" - }, { "sim":97.0, "partner":"1mlr" @@ -875212,11 +878823,11 @@ }, { "sim":97.0, - "partner":"2g0s" + "partner":"1ch2" }, { "sim":97.0, - "partner":"1co9" + "partner":"2g0s" }, { "sim":97.0, @@ -875224,15 +878835,15 @@ }, { "sim":97.0, - "partner":"2g0x" + "partner":"1co9" }, { "sim":97.0, - "partner":"2spl" + "partner":"2g0x" }, { "sim":97.0, - "partner":"1jdo" + "partner":"2spl" }, { "sim":97.0, @@ -875254,10 +878865,22 @@ "sim":97.0, "partner":"2spo" }, + { + "sim":97.0, + "partner":"1jdo" + }, { "sim":97.0, "partner":"2g11" }, + { + "sim":97.0, + "partner":"2g12" + }, + { + "sim":97.0, + "partner":"2g14" + }, { "sim":97.0, "partner":"5yci" @@ -875304,11 +878927,11 @@ }, { "sim":96.0, - "partner":"1dtm" + "partner":"2evp" }, { "sim":96.0, - "partner":"2evp" + "partner":"1dtm" }, { "sim":96.0, @@ -875332,19 +878955,19 @@ }, { "sim":96.0, - "partner":"108m" + "partner":"4h0b" }, { "sim":96.0, - "partner":"4h0b" + "partner":"1ltw" }, { "sim":96.0, - "partner":"1do7" + "partner":"7xc9" }, { "sim":96.0, - "partner":"1ltw" + "partner":"108m" }, { "sim":96.0, @@ -875356,7 +878979,7 @@ }, { "sim":96.0, - "partner":"7xc9" + "partner":"1do7" }, { "sim":96.0, @@ -875368,19 +878991,19 @@ }, { "sim":96.0, - "partner":"1mlk" + "partner":"7ddt" }, { "sim":96.0, - "partner":"1mll" + "partner":"1mlk" }, { "sim":96.0, - "partner":"7ddt" + "partner":"7cen" }, { "sim":96.0, - "partner":"7cen" + "partner":"1mll" }, { "sim":96.0, @@ -875394,6 +879017,14 @@ "sim":96.0, "partner":"1mti" }, + { + "sim":96.0, + "partner":"2oh9" + }, + { + "sim":96.0, + "partner":"2oha" + }, { "sim":96.0, "partner":"1cp5" @@ -875416,7 +879047,7 @@ }, { "sim":96.0, - "partner":"2oh9" + "partner":"4h07" }, { "sim":96.0, @@ -875424,11 +879055,11 @@ }, { "sim":96.0, - "partner":"2oha" + "partner":"7xcq" }, { "sim":96.0, - "partner":"4h07" + "partner":"1mlf" }, { "sim":96.0, @@ -875436,36 +879067,28 @@ }, { "sim":96.0, - "partner":"1do3" - }, - { - "sim":96.0, - "partner":"1do4" + "partner":"1mgn" }, { "sim":96.0, - "partner":"1mlf" + "partner":"1mlg" }, { "sim":96.0, - "partner":"7xcq" + "partner":"1do3" }, { "sim":96.0, - "partner":"1mgn" + "partner":"1mlh" }, { "sim":96.0, - "partner":"1mlg" + "partner":"1do4" }, { "sim":96.0, "partner":"107m" }, - { - "sim":96.0, - "partner":"1mlh" - }, { "sim":95.0, "partner":"5zeo" @@ -875488,27 +879111,23 @@ }, { "sim":95.0, - "partner":"7ehx" + "partner":"1mym" }, { "sim":95.0, "partner":"101m" }, - { - "sim":95.0, - "partner":"1mym" - }, { "sim":95.0, "partner":"4it8" }, { "sim":95.0, - "partner":"1dti" + "partner":"3sdn" }, { "sim":95.0, - "partner":"3sdn" + "partner":"1dti" }, { "sim":95.0, @@ -875522,17 +879141,13 @@ "sim":95.0, "partner":"2mgg" }, - { - "sim":95.0, - "partner":"1cp0" - }, { "sim":95.0, "partner":"2mgh" }, { "sim":95.0, - "partner":"1ch1" + "partner":"8fb0" }, { "sim":95.0, @@ -875544,23 +879159,23 @@ }, { "sim":95.0, - "partner":"4pqc" + "partner":"1cp0" }, { "sim":95.0, - "partner":"8fb0" + "partner":"4pqc" }, { "sim":95.0, - "partner":"1mtj" + "partner":"1ch1" }, { "sim":95.0, - "partner":"2oh8" + "partner":"1mtj" }, { "sim":95.0, - "partner":"1ch5" + "partner":"2oh8" }, { "sim":95.0, @@ -875576,23 +879191,23 @@ }, { "sim":95.0, - "partner":"1ch9" + "partner":"1ch5" }, { "sim":95.0, - "partner":"5ycg" + "partner":"1ch9" }, { - "sim":94.0, - "partner":"6jp1" + "sim":95.0, + "partner":"7ehx" }, { - "sim":94.0, - "partner":"5zzg" + "sim":95.0, + "partner":"5ycg" }, { "sim":94.0, - "partner":"1mbs" + "partner":"6jp1" }, { "sim":94.0, @@ -875612,11 +879227,11 @@ }, { "sim":94.0, - "partner":"5kd1" + "partner":"6krf" }, { "sim":94.0, - "partner":"6krf" + "partner":"5kd1" }, { "sim":94.0, @@ -875642,21 +879257,29 @@ "sim":94.0, "partner":"5zzf" }, + { + "sim":94.0, + "partner":"5zzg" + }, + { + "sim":94.0, + "partner":"1mbs" + }, { "sim":94.0, "partner":"5ilm" }, { "sim":94.0, - "partner":"1mob" + "partner":"8f9n" }, { "sim":94.0, - "partner":"2mga" + "partner":"1mob" }, { "sim":94.0, - "partner":"102m" + "partner":"2mga" }, { "sim":94.0, @@ -875680,47 +879303,51 @@ }, { "sim":94.0, - "partner":"8f9n" + "partner":"2mgd" }, { "sim":94.0, - "partner":"2mgd" + "partner":"102m" }, { "sim":94.0, - "partner":"1h1x" + "partner":"2mge" }, { "sim":94.0, - "partner":"2mge" + "partner":"7ddu" }, { "sim":94.0, - "partner":"103m" + "partner":"8f9h" }, { "sim":94.0, - "partner":"7ddu" + "partner":"8f9i" }, { "sim":94.0, - "partner":"2mgi" + "partner":"1h1x" }, { "sim":94.0, - "partner":"5vzo" + "partner":"103m" }, { "sim":94.0, - "partner":"8f9h" + "partner":"2mgi" }, { "sim":94.0, - "partner":"2mgj" + "partner":"5vzo" }, { "sim":94.0, - "partner":"8f9i" + "partner":"8f9j" + }, + { + "sim":94.0, + "partner":"2mgj" }, { "sim":94.0, @@ -875728,7 +879355,7 @@ }, { "sim":94.0, - "partner":"8f9j" + "partner":"6cf0" }, { "sim":94.0, @@ -875740,16 +879367,12 @@ }, { "sim":94.0, - "partner":"6cf0" + "partner":"7vw4" }, { "sim":94.0, "partner":"5ut8" }, - { - "sim":94.0, - "partner":"7vw4" - }, { "sim":94.0, "partner":"5ut9" @@ -875786,18 +879409,6 @@ "sim":94.0, "partner":"8qba" }, - { - "sim":93.0, - "partner":"2fri" - }, - { - "sim":93.0, - "partner":"2frj" - }, - { - "sim":93.0, - "partner":"3rjn" - }, { "sim":93.0, "partner":"2frk" @@ -875814,10 +879425,6 @@ "sim":93.0, "partner":"5azq" }, - { - "sim":93.0, - "partner":"1dwr" - }, { "sim":93.0, "partner":"2nsr" @@ -875830,14 +879437,6 @@ "sim":93.0, "partner":"5azr" }, - { - "sim":93.0, - "partner":"1dws" - }, - { - "sim":93.0, - "partner":"1gjn" - }, { "sim":93.0, "partner":"1npf" @@ -875854,10 +879453,6 @@ "sim":93.0, "partner":"3mn0" }, - { - "sim":93.0, - "partner":"1dwt" - }, { "sim":93.0, "partner":"1npg" @@ -875870,6 +879465,10 @@ "sim":93.0, "partner":"2v1e" }, + { + "sim":93.0, + "partner":"1dwr" + }, { "sim":93.0, "partner":"2o5m" @@ -875878,6 +879477,14 @@ "sim":93.0, "partner":"2v1f" }, + { + "sim":93.0, + "partner":"1dws" + }, + { + "sim":93.0, + "partner":"1gjn" + }, { "sim":93.0, "partner":"1wla" @@ -875890,6 +879497,10 @@ "sim":93.0, "partner":"3v2z" }, + { + "sim":93.0, + "partner":"1dwt" + }, { "sim":93.0, "partner":"1ymb" @@ -875932,7 +879543,7 @@ }, { "sim":93.0, - "partner":"1azi" + "partner":"7v5p" }, { "sim":93.0, @@ -875944,7 +879555,7 @@ }, { "sim":93.0, - "partner":"7v5p" + "partner":"7dgj" }, { "sim":93.0, @@ -875960,47 +879571,47 @@ }, { "sim":93.0, - "partner":"2vly" + "partner":"7dgk" }, { "sim":93.0, - "partner":"7dgj" + "partner":"1azi" }, { "sim":93.0, - "partner":"2vlz" + "partner":"2vly" }, { "sim":93.0, - "partner":"2vm0" + "partner":"2vlz" }, { "sim":93.0, - "partner":"7dgk" + "partner":"7dgl" }, { "sim":93.0, - "partner":"2o5b" + "partner":"2vm0" }, { "sim":93.0, - "partner":"7dgl" + "partner":"2o5b" }, { "sim":93.0, - "partner":"3wi8" + "partner":"7dgm" }, { "sim":93.0, - "partner":"3ba2" + "partner":"3wi8" }, { "sim":93.0, - "partner":"7dgm" + "partner":"7dgn" }, { "sim":93.0, - "partner":"7dgn" + "partner":"3ba2" }, { "sim":93.0, @@ -876016,23 +879627,15 @@ }, { "sim":93.0, - "partner":"1lue" - }, - { - "sim":93.0, - "partner":"1o16" - }, - { - "sim":93.0, - "partner":"8ess" + "partner":"2fri" }, { "sim":93.0, - "partner":"8esu" + "partner":"2frj" }, { "sim":93.0, - "partner":"6m8f" + "partner":"3rjn" }, { "sim":93.0, @@ -876059,16 +879662,24 @@ "partner":"2e2y" }, { - "sim":92.0, - "partner":"1yca" + "sim":93.0, + "partner":"8ess" }, { - "sim":92.0, - "partner":"1ycb" + "sim":93.0, + "partner":"8esu" }, { - "sim":92.0, - "partner":"6ltl" + "sim":93.0, + "partner":"1lue" + }, + { + "sim":93.0, + "partner":"1o16" + }, + { + "sim":93.0, + "partner":"6m8f" }, { "sim":92.0, @@ -876090,6 +879701,18 @@ "sim":92.0, "partner":"1myj" }, + { + "sim":92.0, + "partner":"1yca" + }, + { + "sim":92.0, + "partner":"6ltl" + }, + { + "sim":92.0, + "partner":"1ycb" + }, { "sim":92.0, "partner":"4twu" @@ -876170,14 +879793,6 @@ "sim":91.0, "partner":"5zze" }, - { - "sim":91.0, - "partner":"1rse" - }, - { - "sim":91.0, - "partner":"5hlq" - }, { "sim":91.0, "partner":"1mno" @@ -876216,11 +879831,11 @@ }, { "sim":91.0, - "partner":"1hrm" + "partner":"8eko" }, { "sim":91.0, - "partner":"8eko" + "partner":"1hrm" }, { "sim":91.0, @@ -876232,11 +879847,11 @@ }, { "sim":91.0, - "partner":"7spe" + "partner":"1rse" }, { "sim":91.0, - "partner":"7spf" + "partner":"5hlq" }, { "sim":91.0, @@ -876266,6 +879881,14 @@ "sim":91.0, "partner":"1ofj" }, + { + "sim":91.0, + "partner":"7spe" + }, + { + "sim":91.0, + "partner":"7spf" + }, { "sim":90.0, "partner":"4tyx" @@ -876326,10 +879949,6 @@ "sim":89.0, "partner":"1hsy" }, - { - "sim":89.0, - "partner":"3k9z" - }, { "sim":89.0, "partner":"1bje" @@ -876380,7 +879999,7 @@ }, { "sim":89.0, - "partner":"7kyr" + "partner":"3k9z" }, { "sim":89.0, @@ -876390,6 +880009,10 @@ "sim":89.0, "partner":"2w6x" }, + { + "sim":89.0, + "partner":"7kyr" + }, { "sim":88.0, "partner":"1mnh" @@ -876452,11 +880075,11 @@ }, { "sim":85.0, - "partner":"7spg" + "partner":"7sph" }, { "sim":85.0, - "partner":"7sph" + "partner":"7spg" }, { "sim":84.0, @@ -876492,11 +880115,11 @@ }, { "sim":62.0, - "partner":"4esa" + "partner":"6rp5" }, { "sim":62.0, - "partner":"6rp5" + "partner":"4esa" }, { "sim":61.0, @@ -876546,10 +880169,6 @@ "sim":60.0, "partner":"3w4u" }, - { - "sim":60.0, - "partner":"3gqg" - }, { "sim":60.0, "partner":"1pbx" @@ -876604,11 +880223,11 @@ }, { "sim":60.0, - "partner":"1hbh" + "partner":"4iro" }, { "sim":60.0, - "partner":"4iro" + "partner":"1hbh" }, { "sim":60.0, @@ -876618,6 +880237,10 @@ "sim":60.0, "partner":"3ng6" }, + { + "sim":60.0, + "partner":"3gqg" + }, { "sim":59.0, "partner":"1faw" @@ -876704,15 +880327,15 @@ }, { "sim":55.0, - "partner":"1v4w" + "partner":"1v4x" }, { "sim":55.0, - "partner":"1v4x" + "partner":"1v4u" }, { "sim":55.0, - "partner":"1v4u" + "partner":"1v4w" }, { "sim":55.0, @@ -876738,18 +880361,6 @@ "sim":54.0, "partner":"1c7d" }, - { - "sim":53.0, - "partner":"1xz5" - }, - { - "sim":53.0, - "partner":"4yu4" - }, - { - "sim":53.0, - "partner":"1vwt" - }, { "sim":53.0, "partner":"1xzv" @@ -876776,7 +880387,15 @@ }, { "sim":53.0, - "partner":"7ud7" + "partner":"1xz5" + }, + { + "sim":53.0, + "partner":"4yu4" + }, + { + "sim":53.0, + "partner":"1vwt" }, { "sim":53.0, @@ -876792,19 +880411,19 @@ }, { "sim":53.0, - "partner":"1y01" + "partner":"8egi" }, { "sim":53.0, - "partner":"7vde" + "partner":"7cue" }, { "sim":53.0, - "partner":"8egi" + "partner":"7vde" }, { "sim":53.0, - "partner":"7cue" + "partner":"1y01" }, { "sim":53.0, @@ -876820,11 +880439,11 @@ }, { "sim":53.0, - "partner":"7uf7" + "partner":"6kye" }, { "sim":53.0, - "partner":"6kye" + "partner":"7uf7" }, { "sim":53.0, @@ -876832,11 +880451,11 @@ }, { "sim":53.0, - "partner":"1bab" + "partner":"7ud7" }, { "sim":53.0, - "partner":"3gys" + "partner":"1bab" }, { "sim":53.0, @@ -876854,6 +880473,10 @@ "sim":53.0, "partner":"3gqp" }, + { + "sim":53.0, + "partner":"3gys" + }, { "sim":53.0, "partner":"1yih" @@ -876868,15 +880491,15 @@ }, { "sim":53.0, - "partner":"1a00" + "partner":"1y7c" }, { "sim":53.0, - "partner":"1y7c" + "partner":"1yeu" }, { "sim":53.0, - "partner":"1yeu" + "partner":"1a00" }, { "sim":53.0, @@ -876896,15 +880519,15 @@ }, { "sim":53.0, - "partner":"1gbu" + "partner":"1y22" }, { "sim":53.0, - "partner":"1hba" + "partner":"1gbu" }, { "sim":53.0, - "partner":"1y22" + "partner":"1hba" }, { "sim":53.0, @@ -876956,16 +880579,12 @@ }, { "sim":52.0, - "partner":"6nbc" + "partner":"6nbd" }, { "sim":52.0, "partner":"4mqi" }, - { - "sim":52.0, - "partner":"6nbd" - }, { "sim":52.0, "partner":"1y0d" @@ -876976,39 +880595,39 @@ }, { "sim":52.0, - "partner":"1hab" + "partner":"6nbc" }, { "sim":52.0, - "partner":"1m9p" + "partner":"1hab" }, { "sim":52.0, - "partner":"1shr" + "partner":"1nqp" }, { "sim":52.0, - "partner":"1si4" + "partner":"1uiw" }, { "sim":52.0, - "partner":"1y0w" + "partner":"1y5k" }, { "sim":52.0, - "partner":"4mqg" + "partner":"1y7z" }, { "sim":52.0, - "partner":"5hu6" + "partner":"1yhe" }, { "sim":52.0, - "partner":"5ksi" + "partner":"2hbs" }, { "sim":52.0, - "partner":"5urc" + "partner":"4n7n" }, { "sim":52.0, @@ -877016,39 +880635,39 @@ }, { "sim":52.0, - "partner":"6xd9" + "partner":"6kae" }, { "sim":52.0, - "partner":"1a0u" + "partner":"6xdt" }, { "sim":52.0, - "partner":"1coh" + "partner":"7jy3" }, { "sim":52.0, - "partner":"1j7w" + "partner":"7uvb" }, { "sim":52.0, - "partner":"1xzu" + "partner":"8fdk" }, { "sim":52.0, - "partner":"1yvq" + "partner":"1a0u" }, { "sim":52.0, - "partner":"2d5z" + "partner":"1coh" }, { "sim":52.0, - "partner":"4n7n" + "partner":"1j7w" }, { "sim":52.0, - "partner":"4rol" + "partner":"5ksj" }, { "sim":52.0, @@ -877070,74 +880689,6 @@ "sim":52.0, "partner":"1j40" }, - { - "sim":52.0, - "partner":"1lfv" - }, - { - "sim":52.0, - "partner":"1nqp" - }, - { - "sim":52.0, - "partner":"1y5k" - }, - { - "sim":52.0, - "partner":"1y7z" - }, - { - "sim":52.0, - "partner":"6kav" - }, - { - "sim":52.0, - "partner":"1bz0" - }, - { - "sim":52.0, - "partner":"1uiw" - }, - { - "sim":52.0, - "partner":"1yhe" - }, - { - "sim":52.0, - "partner":"2hbs" - }, - { - "sim":52.0, - "partner":"7jy3" - }, - { - "sim":52.0, - "partner":"7uvb" - }, - { - "sim":52.0, - "partner":"1hac" - }, - { - "sim":52.0, - "partner":"5ksj" - }, - { - "sim":52.0, - "partner":"6xdt" - }, - { - "sim":52.0, - "partner":"1a0z" - }, - { - "sim":52.0, - "partner":"1bzz" - }, - { - "sim":52.0, - "partner":"1gzx" - }, { "sim":52.0, "partner":"1lfy" @@ -877152,11 +880703,11 @@ }, { "sim":52.0, - "partner":"6kae" + "partner":"6ka9" }, { "sim":52.0, - "partner":"1hco" + "partner":"1bz0" }, { "sim":52.0, @@ -877180,7 +880731,11 @@ }, { "sim":52.0, - "partner":"8fdk" + "partner":"6bwp" + }, + { + "sim":52.0, + "partner":"1hac" }, { "sim":52.0, @@ -877216,7 +880771,19 @@ }, { "sim":52.0, - "partner":"6ka9" + "partner":"8fdl" + }, + { + "sim":52.0, + "partner":"1a0z" + }, + { + "sim":52.0, + "partner":"1bzz" + }, + { + "sim":52.0, + "partner":"1gzx" }, { "sim":52.0, @@ -877232,47 +880799,47 @@ }, { "sim":52.0, - "partner":"6bwp" + "partner":"6kah" }, { "sim":52.0, - "partner":"1j41" + "partner":"6l5v" }, { "sim":52.0, - "partner":"1nih" + "partner":"6nq5" }, { "sim":52.0, - "partner":"1y4r" + "partner":"1hco" }, { "sim":52.0, - "partner":"2hbd" + "partner":"1nih" }, { "sim":52.0, - "partner":"4l7y" + "partner":"1y4r" }, { "sim":52.0, - "partner":"4wjg" + "partner":"2hbd" }, { "sim":52.0, - "partner":"6kah" + "partner":"4l7y" }, { "sim":52.0, - "partner":"6l5v" + "partner":"4wjg" }, { "sim":52.0, - "partner":"6nq5" + "partner":"6l5w" }, { "sim":52.0, - "partner":"8fdl" + "partner":"8dov" }, { "sim":52.0, @@ -877296,7 +880863,11 @@ }, { "sim":52.0, - "partner":"1jy7" + "partner":"6bnr" + }, + { + "sim":52.0, + "partner":"8fdm" }, { "sim":52.0, @@ -877340,11 +880911,15 @@ }, { "sim":52.0, - "partner":"6l5w" + "partner":"6kao" }, { "sim":52.0, - "partner":"1a9w" + "partner":"6l5x" + }, + { + "sim":52.0, + "partner":"1j41" }, { "sim":52.0, @@ -877364,15 +880939,15 @@ }, { "sim":52.0, - "partner":"6bnr" + "partner":"7pcf" }, { "sim":52.0, - "partner":"8dov" + "partner":"7pcq" }, { "sim":52.0, - "partner":"1dxt" + "partner":"1jy7" }, { "sim":52.0, @@ -877392,27 +880967,7 @@ }, { "sim":52.0, - "partner":"6kao" - }, - { - "sim":52.0, - "partner":"6l5x" - }, - { - "sim":52.0, - "partner":"7pcf" - }, - { - "sim":52.0, - "partner":"7pcq" - }, - { - "sim":52.0, - "partner":"8fdm" - }, - { - "sim":52.0, - "partner":"1bij" + "partner":"6kap" }, { "sim":52.0, @@ -877436,7 +880991,11 @@ }, { "sim":52.0, - "partner":"1ird" + "partner":"8fdn" + }, + { + "sim":52.0, + "partner":"1a9w" }, { "sim":52.0, @@ -877464,35 +881023,35 @@ }, { "sim":52.0, - "partner":"6kap" + "partner":"6kai" }, { "sim":52.0, - "partner":"1hho" + "partner":"6kaq" }, { "sim":52.0, - "partner":"1rq4" + "partner":"6l5y" }, { "sim":52.0, - "partner":"1ydz" + "partner":"6lcw" }, { "sim":52.0, - "partner":"1a3n" + "partner":"1dxt" }, { "sim":52.0, - "partner":"1dxu" + "partner":"1rq4" }, { "sim":52.0, - "partner":"1hga" + "partner":"1ydz" }, { "sim":52.0, - "partner":"1j3y" + "partner":"1bij" }, { "sim":52.0, @@ -877512,47 +881071,39 @@ }, { "sim":52.0, - "partner":"6kai" - }, - { - "sim":52.0, - "partner":"6kaq" - }, - { - "sim":52.0, - "partner":"6l5y" + "partner":"6kar" }, { "sim":52.0, - "partner":"6lcw" + "partner":"1ird" }, { "sim":52.0, - "partner":"8fdn" + "partner":"1y7g" }, { "sim":52.0, - "partner":"1cls" + "partner":"1ygf" }, { "sim":52.0, - "partner":"1cmy" + "partner":"3szk" }, { "sim":52.0, - "partner":"1y7g" + "partner":"5x2r" }, { "sim":52.0, - "partner":"1ygf" + "partner":"7jjq" }, { "sim":52.0, - "partner":"3szk" + "partner":"7pch" }, { "sim":52.0, - "partner":"5x2r" + "partner":"1hho" }, { "sim":52.0, @@ -877576,27 +881127,27 @@ }, { "sim":52.0, - "partner":"6kar" + "partner":"6kas" }, { "sim":52.0, - "partner":"7jjq" + "partner":"7jxz" }, { "sim":52.0, - "partner":"7pch" + "partner":"1a3n" }, { "sim":52.0, - "partner":"1gbv" + "partner":"1dxu" }, { "sim":52.0, - "partner":"1hbb" + "partner":"1hga" }, { "sim":52.0, - "partner":"1hdb" + "partner":"1j3y" }, { "sim":52.0, @@ -877624,19 +881175,11 @@ }, { "sim":52.0, - "partner":"7jxz" - }, - { - "sim":52.0, - "partner":"1a3o" - }, - { - "sim":52.0, - "partner":"1dxv" + "partner":"1cls" }, { "sim":52.0, - "partner":"1hgb" + "partner":"1cmy" }, { "sim":52.0, @@ -877668,11 +881211,15 @@ }, { "sim":52.0, - "partner":"6kas" + "partner":"6bwu" }, { "sim":52.0, - "partner":"1c7b" + "partner":"6di4" + }, + { + "sim":52.0, + "partner":"6tb2" }, { "sim":52.0, @@ -877700,107 +881247,107 @@ }, { "sim":52.0, - "partner":"1buw" + "partner":"6xe7" }, { "sim":52.0, - "partner":"4ni1" + "partner":"1gbv" }, { "sim":52.0, - "partner":"6bwu" + "partner":"1hbb" }, { "sim":52.0, - "partner":"6di4" + "partner":"1hdb" }, { "sim":52.0, - "partner":"6tb2" + "partner":"4ni1" }, { "sim":52.0, - "partner":"1k0y" + "partner":"6kat" }, { "sim":52.0, - "partner":"1qsi" + "partner":"6lcx" }, { "sim":52.0, - "partner":"1ye1" + "partner":"7jy0" }, { "sim":52.0, - "partner":"1yh9" + "partner":"1a3o" }, { "sim":52.0, - "partner":"4m4b" + "partner":"1dxv" }, { "sim":52.0, - "partner":"4n7p" + "partner":"1hgb" }, { "sim":52.0, - "partner":"4xs0" + "partner":"1k0y" }, { "sim":52.0, - "partner":"6xe7" + "partner":"1qsi" }, { "sim":52.0, - "partner":"7jy0" + "partner":"1ye1" }, { "sim":52.0, - "partner":"1hbs" + "partner":"1yh9" }, { "sim":52.0, - "partner":"1hgc" + "partner":"4m4b" }, { "sim":52.0, - "partner":"1j3z" + "partner":"4n7p" }, { "sim":52.0, - "partner":"1qxe" + "partner":"4xs0" }, { "sim":52.0, - "partner":"2dn3" + "partner":"6hk2" }, { "sim":52.0, - "partner":"2yrs" + "partner":"1c7b" }, { "sim":52.0, - "partner":"3ic2" + "partner":"1qxe" }, { "sim":52.0, - "partner":"4ij2" + "partner":"2dn3" }, { "sim":52.0, - "partner":"6kat" + "partner":"2yrs" }, { "sim":52.0, - "partner":"6lcx" + "partner":"3ic2" }, { "sim":52.0, - "partner":"1b86" + "partner":"4ij2" }, { "sim":52.0, - "partner":"1fn3" + "partner":"1buw" }, { "sim":52.0, @@ -877828,7 +881375,7 @@ }, { "sim":52.0, - "partner":"6hk2" + "partner":"6hbw" }, { "sim":52.0, @@ -877836,7 +881383,23 @@ }, { "sim":52.0, - "partner":"1fdh" + "partner":"6kau" + }, + { + "sim":52.0, + "partner":"7jy1" + }, + { + "sim":52.0, + "partner":"1hbs" + }, + { + "sim":52.0, + "partner":"1hgc" + }, + { + "sim":52.0, + "partner":"1j3z" }, { "sim":52.0, @@ -877860,11 +881423,15 @@ }, { "sim":52.0, - "partner":"6hbw" + "partner":"6xd9" }, { "sim":52.0, - "partner":"7jy1" + "partner":"1b86" + }, + { + "sim":52.0, + "partner":"1fn3" }, { "sim":52.0, @@ -877884,51 +881451,87 @@ }, { "sim":52.0, - "partner":"6kau" + "partner":"1m9p" }, { "sim":52.0, - "partner":"7qu4" + "partner":"1si4" }, { "sim":52.0, - "partner":"3ia3" + "partner":"1fdh" }, { "sim":52.0, - "partner":"1gli" + "partner":"1shr" }, { "sim":52.0, - "partner":"1o1l" + "partner":"1y0w" }, { "sim":52.0, - "partner":"3gou" + "partner":"4mqg" }, { "sim":52.0, - "partner":"1r1x" + "partner":"5hu6" }, { "sim":52.0, - "partner":"4mqh" + "partner":"5ksi" }, { "sim":52.0, - "partner":"1r1y" + "partner":"5urc" }, { "sim":52.0, - "partner":"6fqf" + "partner":"6kav" }, { "sim":52.0, - "partner":"1cbl" + "partner":"1xzu" }, { "sim":52.0, - "partner":"1xz7" + "partner":"1yvq" + }, + { + "sim":52.0, + "partner":"2d5z" + }, + { + "sim":52.0, + "partner":"4rol" + }, + { + "sim":52.0, + "partner":"1lfv" + }, + { + "sim":52.0, + "partner":"7qu4" + }, + { + "sim":52.0, + "partner":"3ia3" + }, + { + "sim":52.0, + "partner":"1gli" + }, + { + "sim":52.0, + "partner":"4mqh" + }, + { + "sim":52.0, + "partner":"6fqf" + }, + { + "sim":52.0, + "partner":"1r1y" }, { "sim":52.0, @@ -877936,7 +881539,11 @@ }, { "sim":52.0, - "partner":"1cbm" + "partner":"1xz7" + }, + { + "sim":52.0, + "partner":"1cbl" }, { "sim":52.0, @@ -877956,11 +881563,11 @@ }, { "sim":52.0, - "partner":"2qls" + "partner":"1cbm" }, { "sim":52.0, - "partner":"3qjd" + "partner":"2qls" }, { "sim":52.0, @@ -877968,15 +881575,15 @@ }, { "sim":52.0, - "partner":"3nmm" + "partner":"3qjd" }, { "sim":52.0, - "partner":"4mqc" + "partner":"3nmm" }, { "sim":52.0, - "partner":"1j7s" + "partner":"4mqc" }, { "sim":52.0, @@ -877986,26 +881593,42 @@ "sim":52.0, "partner":"3pel" }, + { + "sim":52.0, + "partner":"1j7s" + }, { "sim":52.0, "partner":"1y09" }, + { + "sim":52.0, + "partner":"5woh" + }, + { + "sim":52.0, + "partner":"3gou" + }, { "sim":52.0, "partner":"1fhj" }, { "sim":52.0, - "partner":"5woh" + "partner":"1o1l" }, { "sim":52.0, - "partner":"1abw" + "partner":"1r1x" }, { "sim":52.0, "partner":"1o1p" }, + { + "sim":52.0, + "partner":"1abw" + }, { "sim":52.0, "partner":"1aby" @@ -878189,9 +881812,9 @@ ], "subtitle":"De novo designed pentameric helical bundle protein", "tags":[ - "pentamer", + "helical bundle", "de novo protein", - "helical bundle" + "pentamer" ], "keywords":[ "description", @@ -878340,93 +881963,93 @@ ], "subtitle":"Dphf18 filament", "tags":[ - "filament", "de novo protein", "designed", - "ph" + "ph", + "filament" ], "keywords":[ - "reconfigure", - "containing", - "evolution", - "thus", + "optimized", + "tuned", + "modulating", + "subunit", + "disassembly", "route", - "challenge", - "disassembled", - "fibre", - "drop", + "rapidly", + "fluorescent", + "model", "assembled", - "precise", - "sharp", - "designing", - "structure", + "protein", + "six", + "ph", + "electron", + "following", + "changes", + "rapid", + "microscopy", "networks", - "however", - "built", - "neutral", - "reversible", - "filaments", - "environmental", - "de", - "response", - "rapidly", - "less", - "disassembly", - "remains", - "small", - "midpoint", + "novo", + "unbound", + "precise", + "creating", + "environmentally", "nanostructures", - "assemble", - "units", "dynamic", - "buried", - "atomic", - "force", - "respond", - "transition", + "however", "nearly", + "biological", + "thus", + "residues", + "transition", + "led", + "buried", + "response", + "packing", + "characterization", + "units", "hydrogen", - "fluorescent", - "rapid", - "environmentally", - "following", - "conditions", - "geometry", - "changes", + "small", + "bond", + "evolution", + "subunits", + "computational", "1", - "unbound", - "six", - "provides", + "designing", "design", - "model", - "characterization", - "bond", - "modulating", - "describe", + "drop", + "atomic", + "provides", + "cryogenic", + "respond", + "reversible", + "midpoint", + "conditions", "nanomaterials", - "subunits", - "biological", - "histidine", - "ph", + "identical", + "describe", + "reveal", "fibres", - "packing", - "led", - "optimized", - "novo", + "filaments", + "histidine", + "geometry", + "disassembled", + "built", + "de", "responsive", - "electron", - "residues", - "reveal", - "subunit", - "creating", - "tuned", - "protein", - "microscopy", - "identical", + "remains", + "structure", "nine", - "computational", + "reconfigure", + "neutral", "internal", - "cryogenic" + "fibre", + "force", + "sharp", + "environmental", + "assemble", + "challenge", + "containing", + "less" ], "release_date":"2024-04-10", "publication":"\"De novo design of pH-responsive self-assembling helical protein filaments\", Nat Nanotechnol, 19, 1016-1021", @@ -878611,93 +882234,93 @@ ], "subtitle":"Dphf7 filament", "tags":[ - "filament", "de novo protein", "designed", - "ph" + "ph", + "filament" ], "keywords":[ - "reconfigure", - "containing", - "evolution", - "thus", + "optimized", + "tuned", + "modulating", + "subunit", + "disassembly", "route", - "challenge", - "disassembled", - "fibre", - "drop", + "rapidly", + "fluorescent", + "model", "assembled", - "precise", - "sharp", - "designing", - "structure", + "protein", + "six", + "ph", + "electron", + "following", + "changes", + "rapid", + "microscopy", "networks", - "however", - "built", - "neutral", - "reversible", - "filaments", - "environmental", - "de", - "response", - "rapidly", - "less", - "disassembly", - "remains", - "small", - "midpoint", + "novo", + "unbound", + "precise", + "creating", + "environmentally", "nanostructures", - "assemble", - "units", "dynamic", - "buried", - "atomic", - "force", - "respond", - "transition", + "however", "nearly", + "biological", + "thus", + "residues", + "transition", + "led", + "buried", + "response", + "packing", + "characterization", + "units", "hydrogen", - "fluorescent", - "rapid", - "environmentally", - "following", - "conditions", - "geometry", - "changes", + "small", + "bond", + "evolution", + "subunits", + "computational", "1", - "unbound", - "six", - "provides", + "designing", "design", - "model", - "characterization", - "bond", - "modulating", - "describe", + "drop", + "atomic", + "provides", + "cryogenic", + "respond", + "reversible", + "midpoint", + "conditions", "nanomaterials", - "subunits", - "biological", - "histidine", - "ph", + "identical", + "describe", + "reveal", "fibres", - "packing", - "led", - "optimized", - "novo", + "filaments", + "histidine", + "geometry", + "disassembled", + "built", + "de", "responsive", - "electron", - "residues", - "reveal", - "subunit", - "creating", - "tuned", - "protein", - "microscopy", - "identical", + "remains", + "structure", "nine", - "computational", + "reconfigure", + "neutral", "internal", - "cryogenic" + "fibre", + "force", + "sharp", + "environmental", + "assemble", + "challenge", + "containing", + "less" ], "release_date":"2024-04-10", "publication":"\"De novo design of pH-responsive self-assembling helical protein filaments\", Nat Nanotechnol, 19, 1016-1021", @@ -878766,11 +882389,11 @@ }, { "sim":50.0, - "partner":"6n9h" + "partner":"6naf" }, { "sim":50.0, - "partner":"6naf" + "partner":"6n9h" } ], "seq_thr_sim_natural":[ @@ -878861,109 +882484,109 @@ ], "subtitle":"Crystal structure of a reconstructed kaede-type red fluorescent protein, lea h62x, containing 3-methylhistidine at position 62", "tags":[ - "beta barrel", - "luminescent protein" + "luminescent protein", + "beta barrel" ], "keywords":[ - "bridge", - "crystallography", - "including", - "efficiencies", - "indispensable", - "mutations", + "engineering", "limited", - "potential", + "especially", + "proved", + "role", "show", - "green", - "versatile", - "enhanced", - "trna", - "lea", - "photoswitching", - "photoswitched", + "key", + "photochromic", + "fsrs", + "derivative", + "establishes", + "raman", + "fluorescent", + "luminous", + "bridge", + "various", + "protein", + "probes", + "amber", "anionic", + "sophisticated", + "playing", "aminoacyl", - "develop", - "spectroscopic", - "proteins", - "employed", - "greatly", - "suppression", - "feature", - "interplay", - "advanced", - "trans", - "targeted", + "related", + "using", + "photoconvertible", + "femtosecond", "initial", - "discovering", - "photoconversion", - "mechanistic", - "arise", - "dynamics", - "feedback", "dynamic", - "versus", + "mechanistic", + "final", + "lea", + "transient", + "incorporated", + "subset", + "efficiencies", + "displays", + "orthogonal", + "suppression", + "proteins", + "develop", + "characterization", + "interplay", + "may", + "photoswitched", + "exocyclic", "pairs", - "proved", - "derivative", + "including", + "set", "measurements", - "role", + "spectroscopic", + "enhanced", + "energy", + "photoswitching", + "spectroscopy", + "active", + "feature", "steps", + "potential", + "arise", "properties", - "fluorescent", - "loop", - "fsrs", - "incorporated", - "bright", - "orthogonal", - "stimulated", + "also", + "absorption", "dissipation", - "displays", - "among", - "photochromic", - "may", - "subset", - "active", - "engineering", - "observed", - "fps", - "transient", "reduced", - "characterization", - "using", - "absorption", - "techniques", - "energy", - "key", - "ancestor", - "functionalities", - "femtosecond", + "stimulated", "beneficial", - "sophisticated", - "cis", - "final", + "varying", + "functionalities", + "versatile", + "chromophore", + "trans", + "versus", + "techniques", + "indispensable", + "dynamics", "motion", - "also", - "establishes", - "spectroscopy", "reveal", - "especially", - "raman", - "amber", - "state", - "set", - "photoconvertible", - "protein", + "fps", + "employed", + "targeted", + "trna", + "loop", + "mutations", + "observed", + "feedback", + "discovering", + "cis", + "among", + "photoconversion", "bioimaging", - "various", - "chromophore", - "exocyclic", - "varying", - "luminous", + "crystallography", + "state", + "bright", "investigation", - "playing", - "probes", - "related", + "greatly", + "ancestor", + "green", + "advanced", "five" ], "release_date":"2023-11-29", @@ -879079,11 +882702,15 @@ }, { "sim":394.0, - "partner":"4tzg" + "partner":"4ppk" }, { "sim":394.0, - "partner":"4ppk" + "partner":"4tzg" + }, + { + "sim":393.0, + "partner":"8ul0" }, { "sim":393.0, @@ -879101,18 +882728,6 @@ "sim":393.0, "partner":"8ul5" }, - { - "sim":393.0, - "partner":"8ul0" - }, - { - "sim":393.0, - "partner":"6nqn" - }, - { - "sim":393.0, - "partner":"6nqr" - }, { "sim":393.0, "partner":"6nqo" @@ -879141,6 +882756,14 @@ "sim":393.0, "partner":"6nqq" }, + { + "sim":393.0, + "partner":"6nqn" + }, + { + "sim":393.0, + "partner":"6nqr" + }, { "sim":392.0, "partner":"5exb" @@ -879159,11 +882782,11 @@ }, { "sim":391.0, - "partner":"2vvi" + "partner":"2vvh" }, { "sim":391.0, - "partner":"2vvh" + "partner":"2vvi" }, { "sim":391.0, @@ -879201,10 +882824,6 @@ "sim":389.0, "partner":"2ie2" }, - { - "sim":389.0, - "partner":"5oqe" - }, { "sim":389.0, "partner":"5fvf" @@ -879217,6 +882836,10 @@ "sim":389.0, "partner":"5fvi" }, + { + "sim":389.0, + "partner":"5oqe" + }, { "sim":389.0, "partner":"2z1o" @@ -879249,10 +882872,6 @@ "sim":389.0, "partner":"4ppl" }, - { - "sim":389.0, - "partner":"7rrj" - }, { "sim":389.0, "partner":"2iov" @@ -879269,6 +882888,10 @@ "sim":389.0, "partner":"2pox" }, + { + "sim":389.0, + "partner":"7rrj" + }, { "sim":388.0, "partner":"7rrk" @@ -879279,35 +882902,35 @@ }, { "sim":387.0, - "partner":"7qlk" + "partner":"7qlo" }, { "sim":387.0, - "partner":"7qll" + "partner":"8ul1" }, { "sim":387.0, - "partner":"7qlm" + "partner":"7qli" }, { "sim":387.0, - "partner":"7qln" + "partner":"7qlj" }, { "sim":387.0, - "partner":"7qlo" + "partner":"7qlk" }, { "sim":387.0, - "partner":"7qli" + "partner":"7qll" }, { "sim":387.0, - "partner":"8ul1" + "partner":"7qlm" }, { "sim":387.0, - "partner":"7qlj" + "partner":"7qln" }, { "sim":387.0, @@ -879399,15 +883022,15 @@ }, { "sim":374.0, - "partner":"5hzt" + "partner":"5hzu" }, { "sim":374.0, - "partner":"5hzu" + "partner":"5hzs" }, { "sim":374.0, - "partner":"5hzs" + "partner":"5hzt" }, { "sim":374.0, @@ -879647,11 +883270,11 @@ }, { "sim":260.0, - "partner":"1ggx" + "partner":"1zgo" }, { "sim":260.0, - "partner":"1zgo" + "partner":"1ggx" }, { "sim":259.0, @@ -879727,11 +883350,11 @@ }, { "sim":248.0, - "partner":"3nez" + "partner":"5bql" }, { "sim":248.0, - "partner":"5bql" + "partner":"3nez" }, { "sim":248.0, @@ -879765,10 +883388,6 @@ "sim":246.0, "partner":"2h5q" }, - { - "sim":246.0, - "partner":"8ilx" - }, { "sim":246.0, "partner":"8im0" @@ -879781,6 +883400,10 @@ "sim":246.0, "partner":"6ir1" }, + { + "sim":246.0, + "partner":"8ilx" + }, { "sim":246.0, "partner":"7saj" @@ -880057,10 +883680,6 @@ "sim":229.0, "partner":"3e5t" }, - { - "sim":229.0, - "partner":"3bxc" - }, { "sim":229.0, "partner":"3bx9" @@ -880073,6 +883692,10 @@ "sim":229.0, "partner":"3bxb" }, + { + "sim":229.0, + "partner":"3bxc" + }, { "sim":229.0, "partner":"5yt1" @@ -880119,11 +883742,11 @@ }, { "sim":226.0, - "partner":"3h1o" + "partner":"3h1r" }, { "sim":226.0, - "partner":"3h1r" + "partner":"3h1o" }, { "sim":226.0, @@ -880267,15 +883890,15 @@ }, { "sim":162.0, - "partner":"2a53" + "partner":"2a54" }, { "sim":162.0, - "partner":"2a54" + "partner":"2a56" }, { "sim":162.0, - "partner":"2a56" + "partner":"2a53" }, { "sim":161.0, @@ -880349,10 +883972,6 @@ "sim":104.0, "partner":"8iz0" }, - { - "sim":103.0, - "partner":"2ye0" - }, { "sim":103.0, "partner":"5j2o" @@ -880375,19 +883994,19 @@ }, { "sim":103.0, - "partner":"5ox9" + "partner":"8iz1" }, { "sim":103.0, - "partner":"8iz1" + "partner":"8iz2" }, { "sim":103.0, - "partner":"4ar7" + "partner":"5ox9" }, { "sim":103.0, - "partner":"8iz2" + "partner":"4ar7" }, { "sim":103.0, @@ -880395,11 +884014,11 @@ }, { "sim":103.0, - "partner":"7km4" + "partner":"2ye0" }, { - "sim":102.0, - "partner":"4w6m" + "sim":103.0, + "partner":"7km4" }, { "sim":102.0, @@ -880431,12 +884050,16 @@ }, { "sim":102.0, - "partner":"2ye1" + "partner":"4w6m" }, { "sim":102.0, "partner":"4b5y" }, + { + "sim":102.0, + "partner":"2ye1" + }, { "sim":101.0, "partner":"4w6r" @@ -880447,15 +884070,15 @@ }, { "sim":101.0, - "partner":"7xmf" + "partner":"7xmg" }, { "sim":101.0, - "partner":"7xmg" + "partner":"7xm9" }, { "sim":101.0, - "partner":"7xm9" + "partner":"7xmf" }, { "sim":100.0, @@ -880463,11 +884086,11 @@ }, { "sim":100.0, - "partner":"8g4e" + "partner":"6nhv" }, { "sim":100.0, - "partner":"6nhv" + "partner":"8g4e" }, { "sim":100.0, @@ -880551,19 +884174,19 @@ }, { "sim":98.0, - "partner":"7a7q" + "partner":"7a7s" }, { "sim":98.0, - "partner":"7a7r" + "partner":"7a7t" }, { "sim":98.0, - "partner":"7a7s" + "partner":"7a7q" }, { "sim":98.0, - "partner":"7a7t" + "partner":"7a7r" }, { "sim":98.0, @@ -880573,10 +884196,6 @@ "sim":98.0, "partner":"7vcf" }, - { - "sim":98.0, - "partner":"7ssz" - }, { "sim":98.0, "partner":"8dfl" @@ -880593,6 +884212,10 @@ "sim":98.0, "partner":"7ssy" }, + { + "sim":98.0, + "partner":"7ssz" + }, { "sim":98.0, "partner":"8thr" @@ -880651,11 +884274,11 @@ }, { "sim":96.0, - "partner":"1jc1" + "partner":"1q73" }, { "sim":96.0, - "partner":"1q73" + "partner":"1jc1" }, { "sim":96.0, @@ -880679,15 +884302,15 @@ }, { "sim":96.0, - "partner":"7bym" + "partner":"7byn" }, { "sim":96.0, - "partner":"7byn" + "partner":"7byl" }, { "sim":96.0, - "partner":"7byl" + "partner":"7bym" }, { "sim":96.0, @@ -880751,31 +884374,23 @@ }, { "sim":95.0, - "partner":"1q4c" - }, - { - "sim":95.0, - "partner":"1q4d" - }, - { - "sim":95.0, - "partner":"1jby" + "partner":"8jl2" }, { "sim":95.0, - "partner":"1jbz" + "partner":"8jkc" }, { "sim":95.0, - "partner":"8jl2" + "partner":"8jkg" }, { "sim":95.0, - "partner":"8jkc" + "partner":"1jby" }, { "sim":95.0, - "partner":"8jkg" + "partner":"1jbz" }, { "sim":95.0, @@ -880813,13 +884428,21 @@ "sim":95.0, "partner":"8jll" }, + { + "sim":95.0, + "partner":"8jlm" + }, { "sim":95.0, "partner":"2wur" }, { "sim":95.0, - "partner":"8jlm" + "partner":"1q4c" + }, + { + "sim":95.0, + "partner":"1q4d" }, { "sim":95.0, @@ -880857,14 +884480,6 @@ "sim":95.0, "partner":"6h01" }, - { - "sim":95.0, - "partner":"7a8d" - }, - { - "sim":95.0, - "partner":"7a8e" - }, { "sim":95.0, "partner":"7a7w" @@ -880911,11 +884526,15 @@ }, { "sim":95.0, - "partner":"6m63" + "partner":"7a8d" }, { "sim":95.0, - "partner":"6wvi" + "partner":"7a8e" + }, + { + "sim":95.0, + "partner":"6m63" }, { "sim":95.0, @@ -880935,23 +884554,23 @@ }, { "sim":95.0, - "partner":"6dgv" + "partner":"6wvi" }, { "sim":95.0, - "partner":"7v80" + "partner":"6dgv" }, { "sim":95.0, - "partner":"7v87" + "partner":"7v81" }, { "sim":95.0, - "partner":"7v81" + "partner":"7v88" }, { "sim":95.0, - "partner":"7v88" + "partner":"8xal" }, { "sim":95.0, @@ -880963,15 +884582,15 @@ }, { "sim":95.0, - "partner":"7v83" + "partner":"7edj" }, { "sim":95.0, - "partner":"7v8a" + "partner":"7v83" }, { "sim":95.0, - "partner":"7edj" + "partner":"7v8a" }, { "sim":95.0, @@ -880993,6 +884612,14 @@ "sim":95.0, "partner":"7v86" }, + { + "sim":95.0, + "partner":"7v80" + }, + { + "sim":95.0, + "partner":"7v87" + }, { "sim":95.0, "partner":"7fhk" @@ -881013,10 +884640,6 @@ "sim":95.0, "partner":"4p7h" }, - { - "sim":95.0, - "partner":"7zji" - }, { "sim":95.0, "partner":"7zjd" @@ -881037,6 +884660,10 @@ "sim":95.0, "partner":"4pa0" }, + { + "sim":95.0, + "partner":"7zji" + }, { "sim":95.0, "partner":"7ysj" @@ -881063,11 +884690,11 @@ }, { "sim":94.0, - "partner":"5btt" + "partner":"5nhn" }, { "sim":94.0, - "partner":"5nhn" + "partner":"5btt" }, { "sim":94.0, @@ -881111,35 +884738,35 @@ }, { "sim":94.0, - "partner":"2hqz" + "partner":"2ah8" }, { "sim":94.0, - "partner":"2hrs" + "partner":"8rlb" }, { "sim":94.0, - "partner":"2q6p" + "partner":"1f09" }, { "sim":94.0, - "partner":"7amf" + "partner":"8rlc" }, { "sim":94.0, - "partner":"2ah8" + "partner":"1f0b" }, { "sim":94.0, - "partner":"1f09" + "partner":"8rle" }, { "sim":94.0, - "partner":"1f0b" + "partner":"7amb" }, { "sim":94.0, - "partner":"7amb" + "partner":"7amf" }, { "sim":94.0, @@ -881147,51 +884774,51 @@ }, { "sim":94.0, - "partner":"5dpj" + "partner":"2hqz" }, { "sim":94.0, - "partner":"1emc" + "partner":"2hrs" }, { "sim":94.0, - "partner":"1eme" + "partner":"2q6p" }, { "sim":94.0, - "partner":"1eml" + "partner":"8rl9" }, { "sim":94.0, - "partner":"5ehu" + "partner":"5dpj" }, { "sim":94.0, - "partner":"5dph" + "partner":"1emc" }, { "sim":94.0, - "partner":"6dq1" + "partner":"1eme" }, { "sim":94.0, - "partner":"2h9w" + "partner":"6dq1" }, { "sim":94.0, - "partner":"6gqh" + "partner":"5ehu" }, { "sim":94.0, - "partner":"6go8" + "partner":"5dph" }, { "sim":94.0, - "partner":"6grm" + "partner":"1eml" }, { "sim":94.0, - "partner":"6go9" + "partner":"2h9w" }, { "sim":94.0, @@ -881215,63 +884842,59 @@ }, { "sim":94.0, - "partner":"4lqt" - }, - { - "sim":94.0, - "partner":"4lqu" + "partner":"6gqh" }, { "sim":94.0, - "partner":"5jzk" + "partner":"6go8" }, { "sim":94.0, - "partner":"5jzl" + "partner":"6grm" }, { "sim":94.0, - "partner":"3cd9" + "partner":"6go9" }, { "sim":94.0, - "partner":"3cd1" + "partner":"4lqt" }, { "sim":94.0, - "partner":"8uqq" + "partner":"4lqu" }, { "sim":94.0, - "partner":"5mfc" + "partner":"5jzk" }, { "sim":94.0, - "partner":"5dtz" + "partner":"5jzl" }, { "sim":94.0, - "partner":"5du0" + "partner":"3cd9" }, { "sim":94.0, - "partner":"7a7m" + "partner":"3cd1" }, { "sim":94.0, - "partner":"7a7n" + "partner":"8uqq" }, { "sim":94.0, - "partner":"7a7o" + "partner":"5mfc" }, { "sim":94.0, - "partner":"7a8f" + "partner":"5dtz" }, { "sim":94.0, - "partner":"7a7p" + "partner":"5du0" }, { "sim":94.0, @@ -881283,23 +884906,23 @@ }, { "sim":94.0, - "partner":"4xov" + "partner":"7a7z" }, { "sim":94.0, - "partner":"4xow" + "partner":"7a80" }, { "sim":94.0, - "partner":"7a7z" + "partner":"4xov" }, { "sim":94.0, - "partner":"7a80" + "partner":"7a8l" }, { "sim":94.0, - "partner":"7a8l" + "partner":"4xow" }, { "sim":94.0, @@ -881329,6 +884952,26 @@ "sim":94.0, "partner":"7a8c" }, + { + "sim":94.0, + "partner":"7a7m" + }, + { + "sim":94.0, + "partner":"7a7n" + }, + { + "sim":94.0, + "partner":"7a7o" + }, + { + "sim":94.0, + "partner":"7a8f" + }, + { + "sim":94.0, + "partner":"7a7p" + }, { "sim":94.0, "partner":"6uhj" @@ -881429,10 +885072,6 @@ "sim":94.0, "partner":"7x5v" }, - { - "sim":94.0, - "partner":"8j1e" - }, { "sim":94.0, "partner":"8j0j" @@ -881445,6 +885084,10 @@ "sim":94.0, "partner":"8gw7" }, + { + "sim":94.0, + "partner":"8j1e" + }, { "sim":94.0, "partner":"7aa5" @@ -881475,11 +885118,11 @@ }, { "sim":93.0, - "partner":"1rmp" + "partner":"1rmm" }, { "sim":93.0, - "partner":"1rmm" + "partner":"1rmp" }, { "sim":93.0, @@ -881505,10 +885148,6 @@ "sim":93.0, "partner":"3vht" }, - { - "sim":93.0, - "partner":"1qyq" - }, { "sim":93.0, "partner":"3gl4" @@ -881519,11 +885158,7 @@ }, { "sim":93.0, - "partner":"1rmo" - }, - { - "sim":93.0, - "partner":"1q4e" + "partner":"1qyq" }, { "sim":93.0, @@ -881531,11 +885166,11 @@ }, { "sim":93.0, - "partner":"1ema" + "partner":"6xzf" }, { "sim":93.0, - "partner":"1emb" + "partner":"1ema" }, { "sim":93.0, @@ -881547,7 +885182,7 @@ }, { "sim":93.0, - "partner":"6xzf" + "partner":"1emb" }, { "sim":93.0, @@ -881559,11 +885194,11 @@ }, { "sim":93.0, - "partner":"1c4f" + "partner":"2okw" }, { "sim":93.0, - "partner":"2okw" + "partner":"1c4f" }, { "sim":93.0, @@ -881617,6 +885252,14 @@ "sim":93.0, "partner":"4kex" }, + { + "sim":93.0, + "partner":"1rmo" + }, + { + "sim":93.0, + "partner":"1q4e" + }, { "sim":93.0, "partner":"4eul" @@ -881639,15 +885282,15 @@ }, { "sim":93.0, - "partner":"1emm" + "partner":"5dpg" }, { "sim":93.0, - "partner":"5dpg" + "partner":"8dpd" }, { "sim":93.0, - "partner":"8dpd" + "partner":"1emm" }, { "sim":93.0, @@ -881655,11 +885298,11 @@ }, { "sim":93.0, - "partner":"2hgd" + "partner":"7sai" }, { "sim":93.0, - "partner":"7sai" + "partner":"2hgd" }, { "sim":93.0, @@ -881677,10 +885320,6 @@ "sim":93.0, "partner":"4n3d" }, - { - "sim":93.0, - "partner":"5ma4" - }, { "sim":93.0, "partner":"5ma5" @@ -881709,6 +885348,10 @@ "sim":93.0, "partner":"5ma3" }, + { + "sim":93.0, + "partner":"5ma4" + }, { "sim":93.0, "partner":"5yr2" @@ -881771,7 +885414,7 @@ }, { "sim":93.0, - "partner":"8am4" + "partner":"7amu" }, { "sim":93.0, @@ -881779,7 +885422,7 @@ }, { "sim":93.0, - "partner":"7amu" + "partner":"6ylp" }, { "sim":93.0, @@ -881791,7 +885434,7 @@ }, { "sim":93.0, - "partner":"6ylp" + "partner":"6ylq" }, { "sim":93.0, @@ -881801,10 +885444,6 @@ "sim":93.0, "partner":"8ahb" }, - { - "sim":93.0, - "partner":"6ylq" - }, { "sim":93.0, "partner":"7o7u" @@ -881817,13 +885456,17 @@ "sim":93.0, "partner":"8a7v" }, + { + "sim":93.0, + "partner":"6un4" + }, { "sim":93.0, "partner":"8a6q" }, { "sim":93.0, - "partner":"6un4" + "partner":"6t39" }, { "sim":93.0, @@ -881835,7 +885478,7 @@ }, { "sim":93.0, - "partner":"6t39" + "partner":"6t3a" }, { "sim":93.0, @@ -881843,16 +885486,12 @@ }, { "sim":93.0, - "partner":"6t3a" + "partner":"6pfr" }, { "sim":93.0, "partner":"8a83" }, - { - "sim":93.0, - "partner":"6pfr" - }, { "sim":93.0, "partner":"6pfs" @@ -881877,6 +885516,10 @@ "sim":93.0, "partner":"8a6g" }, + { + "sim":93.0, + "partner":"8am4" + }, { "sim":93.0, "partner":"8jzu" @@ -881931,15 +885574,15 @@ }, { "sim":93.0, - "partner":"7a8g" + "partner":"7a8j" }, { "sim":93.0, - "partner":"7a8j" + "partner":"7a8k" }, { "sim":93.0, - "partner":"7a8k" + "partner":"7a8g" }, { "sim":93.0, @@ -882219,11 +885862,11 @@ }, { "sim":93.0, - "partner":"6uz3" + "partner":"7k18" }, { "sim":93.0, - "partner":"7k18" + "partner":"7fbs" }, { "sim":93.0, @@ -882231,15 +885874,15 @@ }, { "sim":93.0, - "partner":"7fbs" + "partner":"6uz0" }, { "sim":93.0, - "partner":"6uz0" + "partner":"7xsu" }, { "sim":93.0, - "partner":"7xsu" + "partner":"6uz3" }, { "sim":93.0, @@ -882265,10 +885908,6 @@ "sim":92.0, "partner":"1rrx" }, - { - "sim":92.0, - "partner":"4p1q" - }, { "sim":92.0, "partner":"6kkz" @@ -882295,19 +885934,19 @@ }, { "sim":92.0, - "partner":"6kl1" + "partner":"4p1q" }, { "sim":92.0, - "partner":"5aqb" + "partner":"6kl1" }, { "sim":92.0, - "partner":"5hzo" + "partner":"5aqb" }, { "sim":92.0, - "partner":"4b30" + "partner":"5hzo" }, { "sim":92.0, @@ -882315,15 +885954,7 @@ }, { "sim":92.0, - "partner":"2dui" - }, - { - "sim":92.0, - "partner":"7cd7" - }, - { - "sim":92.0, - "partner":"7cd8" + "partner":"4b30" }, { "sim":92.0, @@ -882339,11 +885970,11 @@ }, { "sim":92.0, - "partner":"1b9c" + "partner":"1w7u" }, { "sim":92.0, - "partner":"1w7u" + "partner":"1b9c" }, { "sim":92.0, @@ -882365,13 +885996,21 @@ "sim":92.0, "partner":"7yv3" }, + { + "sim":92.0, + "partner":"7yv5" + }, + { + "sim":92.0, + "partner":"7cd7" + }, { "sim":92.0, "partner":"1gfl" }, { "sim":92.0, - "partner":"7yv5" + "partner":"3g9a" }, { "sim":92.0, @@ -882379,7 +886018,11 @@ }, { "sim":92.0, - "partner":"3g9a" + "partner":"2dui" + }, + { + "sim":92.0, + "partner":"7cd8" }, { "sim":92.0, @@ -882413,10 +886056,6 @@ "sim":92.0, "partner":"8dta" }, - { - "sim":92.0, - "partner":"8dhy" - }, { "sim":92.0, "partner":"2qu1" @@ -882427,15 +886066,7 @@ }, { "sim":92.0, - "partner":"3dqc" - }, - { - "sim":92.0, - "partner":"3dqd" - }, - { - "sim":92.0, - "partner":"3dqe" + "partner":"8dhy" }, { "sim":92.0, @@ -882529,6 +886160,18 @@ "sim":92.0, "partner":"3dqa" }, + { + "sim":92.0, + "partner":"3dqc" + }, + { + "sim":92.0, + "partner":"3dqd" + }, + { + "sim":92.0, + "partner":"3dqe" + }, { "sim":92.0, "partner":"3gex" @@ -882573,10 +886216,6 @@ "sim":92.0, "partner":"2q57" }, - { - "sim":92.0, - "partner":"3sv5" - }, { "sim":92.0, "partner":"3ssh" @@ -882613,6 +886252,10 @@ "sim":92.0, "partner":"3ss0" }, + { + "sim":92.0, + "partner":"3sv5" + }, { "sim":92.0, "partner":"8et3" @@ -882711,11 +886354,11 @@ }, { "sim":91.0, - "partner":"1emf" + "partner":"2emd" }, { "sim":91.0, - "partner":"2emd" + "partner":"1emf" }, { "sim":91.0, @@ -882731,15 +886374,11 @@ }, { "sim":91.0, - "partner":"2emn" - }, - { - "sim":91.0, - "partner":"2emo" + "partner":"6qq8" }, { "sim":91.0, - "partner":"6qq8" + "partner":"2emn" }, { "sim":91.0, @@ -882747,7 +886386,7 @@ }, { "sim":91.0, - "partner":"5dpi" + "partner":"2emo" }, { "sim":91.0, @@ -882757,6 +886396,10 @@ "sim":91.0, "partner":"6qqb" }, + { + "sim":91.0, + "partner":"5dpi" + }, { "sim":91.0, "partner":"2wso" @@ -882821,10 +886464,6 @@ "sim":91.0, "partner":"7st4" }, - { - "sim":91.0, - "partner":"3sg5" - }, { "sim":91.0, "partner":"3wlc" @@ -882837,6 +886476,10 @@ "sim":91.0, "partner":"3sg4" }, + { + "sim":91.0, + "partner":"3sg5" + }, { "sim":91.0, "partner":"7e9y" @@ -882877,21 +886520,13 @@ "sim":90.0, "partner":"1qxt" }, - { - "sim":90.0, - "partner":"1qyo" - }, { "sim":90.0, "partner":"6b7r" }, { "sim":90.0, - "partner":"1kyp" - }, - { - "sim":90.0, - "partner":"2g6e" + "partner":"1qyo" }, { "sim":90.0, @@ -882931,19 +886566,23 @@ }, { "sim":90.0, - "partner":"4rtc" + "partner":"1kyp" }, { "sim":90.0, - "partner":"3evr" + "partner":"2g6e" }, { "sim":90.0, - "partner":"4ik5" + "partner":"4rtc" }, { "sim":90.0, - "partner":"3sg7" + "partner":"3evr" + }, + { + "sim":90.0, + "partner":"4ik5" }, { "sim":90.0, @@ -882965,6 +886604,10 @@ "sim":90.0, "partner":"4ik4" }, + { + "sim":90.0, + "partner":"3sg7" + }, { "sim":90.0, "partner":"3ek7" @@ -883027,15 +886670,15 @@ }, { "sim":89.0, - "partner":"6ya9" + "partner":"6zsm" }, { "sim":89.0, - "partner":"6zsm" + "partner":"6zsn" }, { "sim":89.0, - "partner":"6zsn" + "partner":"6ya9" }, { "sim":89.0, @@ -883111,19 +886754,19 @@ }, { "sim":76.0, - "partner":"7y40" + "partner":"7yao" }, { "sim":76.0, - "partner":"8gyf" + "partner":"7yre" }, { "sim":76.0, - "partner":"7yao" + "partner":"8gyf" }, { "sim":76.0, - "partner":"7yre" + "partner":"7y40" }, { "sim":75.0, @@ -883139,19 +886782,19 @@ }, { "sim":72.0, - "partner":"6j1a" + "partner":"6jxf" }, { "sim":72.0, - "partner":"6j1b" + "partner":"6j1a" }, { "sim":72.0, - "partner":"6j1c" + "partner":"6j1b" }, { "sim":72.0, - "partner":"6jxf" + "partner":"6j1c" }, { "sim":71.0, @@ -883179,11 +886822,11 @@ }, { "sim":68.0, - "partner":"7z7p" + "partner":"7z7o" }, { "sim":68.0, - "partner":"7z7o" + "partner":"7z7p" }, { "sim":68.0, @@ -883253,10 +886896,6 @@ "sim":65.0, "partner":"6ogc" }, - { - "sim":65.0, - "partner":"4zf3" - }, { "sim":65.0, "partner":"6un5" @@ -883270,13 +886909,17 @@ "partner":"6un7" }, { - "sim":64.0, - "partner":"2g6x" + "sim":65.0, + "partner":"4zf3" }, { "sim":64.0, "partner":"2g6y" }, + { + "sim":64.0, + "partner":"2g6x" + }, { "sim":64.0, "partner":"6og8" @@ -883724,93 +887367,93 @@ ], "subtitle":"Dphf19 filament", "tags":[ - "filament", "de novo protein", "designed", - "ph" + "ph", + "filament" ], "keywords":[ - "reconfigure", - "containing", - "evolution", - "thus", + "optimized", + "tuned", + "modulating", + "subunit", + "disassembly", "route", - "challenge", - "disassembled", - "fibre", - "drop", + "rapidly", + "fluorescent", + "model", "assembled", - "precise", - "sharp", - "designing", - "structure", + "protein", + "six", + "ph", + "electron", + "following", + "changes", + "rapid", + "microscopy", "networks", - "however", - "built", - "neutral", - "reversible", - "filaments", - "environmental", - "de", - "response", - "rapidly", - "less", - "disassembly", - "remains", - "small", - "midpoint", + "novo", + "unbound", + "precise", + "creating", + "environmentally", "nanostructures", - "assemble", - "units", "dynamic", - "buried", - "atomic", - "force", - "respond", - "transition", + "however", "nearly", + "biological", + "thus", + "residues", + "transition", + "led", + "buried", + "response", + "packing", + "characterization", + "units", "hydrogen", - "fluorescent", - "rapid", - "environmentally", - "following", - "conditions", - "geometry", - "changes", + "small", + "bond", + "evolution", + "subunits", + "computational", "1", - "unbound", - "six", - "provides", + "designing", "design", - "model", - "characterization", - "bond", - "modulating", - "describe", + "drop", + "atomic", + "provides", + "cryogenic", + "respond", + "reversible", + "midpoint", + "conditions", "nanomaterials", - "subunits", - "biological", - "histidine", - "ph", + "identical", + "describe", + "reveal", "fibres", - "packing", - "led", - "optimized", - "novo", + "filaments", + "histidine", + "geometry", + "disassembled", + "built", + "de", "responsive", - "electron", - "residues", - "reveal", - "subunit", - "creating", - "tuned", - "protein", - "microscopy", - "identical", + "remains", + "structure", "nine", - "computational", + "reconfigure", + "neutral", "internal", - "cryogenic" + "fibre", + "force", + "sharp", + "environmental", + "assemble", + "challenge", + "containing", + "less" ], "release_date":"2024-04-10", "publication":"\"De novo design of pH-responsive self-assembling helical protein filaments\", Nat Nanotechnol, 19, 1016-1021", @@ -883903,29 +887546,25 @@ "sim":508.0, "partner":"2b3p" }, - { - "sim":506.0, - "partner":"4j8a" - }, { "sim":506.0, "partner":"8ovy" }, { "sim":506.0, - "partner":"7v80" + "partner":"4j8a" }, { "sim":506.0, - "partner":"7v87" + "partner":"7v81" }, { "sim":506.0, - "partner":"7v81" + "partner":"7v88" }, { "sim":506.0, - "partner":"7v88" + "partner":"8xal" }, { "sim":506.0, @@ -883937,15 +887576,15 @@ }, { "sim":506.0, - "partner":"7v83" + "partner":"7edj" }, { "sim":506.0, - "partner":"7v8a" + "partner":"7v83" }, { "sim":506.0, - "partner":"7edj" + "partner":"7v8a" }, { "sim":506.0, @@ -883967,6 +887606,14 @@ "sim":506.0, "partner":"7v86" }, + { + "sim":506.0, + "partner":"7v80" + }, + { + "sim":506.0, + "partner":"7v87" + }, { "sim":505.0, "partner":"8dhr" @@ -883983,10 +887630,6 @@ "sim":501.0, "partner":"7aa5" }, - { - "sim":500.0, - "partner":"8j1e" - }, { "sim":500.0, "partner":"8j0j" @@ -883999,6 +887642,10 @@ "sim":500.0, "partner":"8gw7" }, + { + "sim":500.0, + "partner":"8j1e" + }, { "sim":499.0, "partner":"7km4" @@ -884025,15 +887672,31 @@ }, { "sim":497.0, - "partner":"7xmf" + "partner":"7xmg" }, { "sim":497.0, - "partner":"7xmg" + "partner":"7xm9" }, { "sim":497.0, - "partner":"7xm9" + "partner":"7xmf" + }, + { + "sim":496.0, + "partner":"8rlb" + }, + { + "sim":496.0, + "partner":"8rlc" + }, + { + "sim":496.0, + "partner":"8rle" + }, + { + "sim":496.0, + "partner":"8rl9" }, { "sim":496.0, @@ -884069,15 +887732,15 @@ }, { "sim":494.0, - "partner":"5ehu" + "partner":"6dq1" }, { "sim":494.0, - "partner":"5dph" + "partner":"5ehu" }, { "sim":494.0, - "partner":"6dq1" + "partner":"5dph" }, { "sim":494.0, @@ -884163,10 +887826,6 @@ "sim":491.0, "partner":"7fho" }, - { - "sim":491.0, - "partner":"7zji" - }, { "sim":491.0, "partner":"7zjd" @@ -884183,6 +887842,10 @@ "sim":491.0, "partner":"7zjh" }, + { + "sim":491.0, + "partner":"7zji" + }, { "sim":490.0, "partner":"5dtz" @@ -884265,35 +887928,35 @@ }, { "sim":486.0, - "partner":"7a8d" + "partner":"4xov" }, { "sim":486.0, - "partner":"7a8e" + "partner":"7a8l" }, { "sim":486.0, - "partner":"7a7o" + "partner":"4xow" }, { "sim":486.0, - "partner":"7a7p" + "partner":"7a8m" }, { "sim":486.0, - "partner":"4xov" + "partner":"7a8d" }, { "sim":486.0, - "partner":"4xow" + "partner":"7a8e" }, { "sim":486.0, - "partner":"7a8l" + "partner":"7a7o" }, { "sim":486.0, - "partner":"7a8m" + "partner":"7a7p" }, { "sim":486.0, @@ -884333,23 +887996,23 @@ }, { "sim":484.0, - "partner":"7cd7" + "partner":"6ir6" }, { "sim":484.0, - "partner":"7cd8" + "partner":"7pca" }, { "sim":484.0, - "partner":"6ir6" + "partner":"2qt2" }, { "sim":484.0, - "partner":"7pca" + "partner":"7cd7" }, { "sim":484.0, - "partner":"2qt2" + "partner":"7cd8" }, { "sim":484.0, @@ -884373,43 +888036,43 @@ }, { "sim":484.0, - "partner":"7a7m" + "partner":"7a7z" }, { "sim":484.0, - "partner":"7a7n" + "partner":"7a80" }, { "sim":484.0, - "partner":"7a8f" + "partner":"7a8n" }, { "sim":484.0, - "partner":"7a7z" + "partner":"7a85" }, { "sim":484.0, - "partner":"7a80" + "partner":"7a86" }, { "sim":484.0, - "partner":"7a8n" + "partner":"7a87" }, { "sim":484.0, - "partner":"7a85" + "partner":"7a88" }, { "sim":484.0, - "partner":"7a86" + "partner":"7a7m" }, { "sim":484.0, - "partner":"7a87" + "partner":"7a7n" }, { "sim":484.0, - "partner":"7a88" + "partner":"7a8f" }, { "sim":484.0, @@ -884461,11 +888124,11 @@ }, { "sim":484.0, - "partner":"6uz3" + "partner":"7k18" }, { "sim":484.0, - "partner":"7k18" + "partner":"7fbs" }, { "sim":484.0, @@ -884473,15 +888136,15 @@ }, { "sim":484.0, - "partner":"7fbs" + "partner":"6uz0" }, { "sim":484.0, - "partner":"6uz0" + "partner":"7xsu" }, { "sim":484.0, - "partner":"7xsu" + "partner":"6uz3" }, { "sim":484.0, @@ -884497,11 +888160,11 @@ }, { "sim":483.0, - "partner":"8g4e" + "partner":"6nhv" }, { "sim":483.0, - "partner":"6nhv" + "partner":"8g4e" }, { "sim":483.0, @@ -884509,15 +888172,15 @@ }, { "sim":483.0, - "partner":"1kyp" + "partner":"1kyr" }, { "sim":483.0, - "partner":"1kyr" + "partner":"1kys" }, { "sim":483.0, - "partner":"1kys" + "partner":"1kyp" }, { "sim":483.0, @@ -884611,10 +888274,6 @@ "sim":482.0, "partner":"3ogo" }, - { - "sim":482.0, - "partner":"7a8g" - }, { "sim":482.0, "partner":"7a8h" @@ -884657,31 +888316,35 @@ }, { "sim":482.0, - "partner":"8u4n" + "partner":"7a8g" }, { "sim":482.0, - "partner":"8u4o" + "partner":"8u4r" }, { "sim":482.0, - "partner":"8u4t" + "partner":"8u4s" }, { "sim":482.0, - "partner":"8u4p" + "partner":"8u4n" }, { "sim":482.0, - "partner":"8u4q" + "partner":"8u4o" }, { "sim":482.0, - "partner":"8u4r" + "partner":"8u4t" }, { "sim":482.0, - "partner":"8u4s" + "partner":"8u4p" + }, + { + "sim":482.0, + "partner":"8u4q" }, { "sim":482.0, @@ -884697,39 +888360,39 @@ }, { "sim":481.0, - "partner":"1qyo" + "partner":"7pd0" }, { "sim":481.0, - "partner":"2hrs" + "partner":"2okw" }, { "sim":481.0, - "partner":"2q6p" + "partner":"2oky" }, { "sim":481.0, - "partner":"2okw" + "partner":"1qyo" }, { "sim":481.0, - "partner":"7pd0" + "partner":"2hrs" }, { "sim":481.0, - "partner":"2oky" + "partner":"2q6p" }, { "sim":481.0, - "partner":"2g6e" + "partner":"7sah" }, { "sim":481.0, - "partner":"7sah" + "partner":"7sai" }, { "sim":481.0, - "partner":"7sai" + "partner":"2g6e" }, { "sim":481.0, @@ -884797,11 +888460,11 @@ }, { "sim":480.0, - "partner":"2ye0" + "partner":"4ar7" }, { "sim":480.0, - "partner":"4ar7" + "partner":"2ye0" }, { "sim":480.0, @@ -884813,15 +888476,15 @@ }, { "sim":479.0, - "partner":"1ema" + "partner":"6xzf" }, { "sim":479.0, - "partner":"1emb" + "partner":"1ema" }, { "sim":479.0, - "partner":"6xzf" + "partner":"1emb" }, { "sim":479.0, @@ -884867,6 +888530,10 @@ "sim":479.0, "partner":"5wj4" }, + { + "sim":479.0, + "partner":"6gqg" + }, { "sim":479.0, "partner":"6gqh" @@ -884883,18 +888550,6 @@ "sim":479.0, "partner":"6go9" }, - { - "sim":479.0, - "partner":"6gqg" - }, - { - "sim":479.0, - "partner":"5ma4" - }, - { - "sim":479.0, - "partner":"2ye1" - }, { "sim":479.0, "partner":"5ma5" @@ -884931,6 +888586,14 @@ "sim":479.0, "partner":"5ma3" }, + { + "sim":479.0, + "partner":"5ma4" + }, + { + "sim":479.0, + "partner":"2ye1" + }, { "sim":479.0, "partner":"2y0g" @@ -885005,47 +888668,47 @@ }, { "sim":478.0, - "partner":"1q4c" + "partner":"1z1p" }, { "sim":478.0, - "partner":"1q4d" + "partner":"1w7s" }, { "sim":478.0, - "partner":"1q4e" + "partner":"1z1q" }, { "sim":478.0, - "partner":"1z1p" + "partner":"1s6z" }, { "sim":478.0, - "partner":"1w7s" + "partner":"7yv3" }, { "sim":478.0, - "partner":"1z1q" + "partner":"7yv5" }, { "sim":478.0, - "partner":"1s6z" + "partner":"1bfp" }, { "sim":478.0, - "partner":"7yv3" + "partner":"1gfl" }, { "sim":478.0, - "partner":"1bfp" + "partner":"1q4c" }, { "sim":478.0, - "partner":"1gfl" + "partner":"1q4d" }, { "sim":478.0, - "partner":"7yv5" + "partner":"1q4e" }, { "sim":478.0, @@ -885115,17 +888778,13 @@ "sim":478.0, "partner":"8htt" }, - { - "sim":477.0, - "partner":"5btt" - }, { "sim":477.0, "partner":"5nhn" }, { "sim":477.0, - "partner":"7amf" + "partner":"5btt" }, { "sim":477.0, @@ -885139,6 +888798,10 @@ "sim":477.0, "partner":"7amb" }, + { + "sim":477.0, + "partner":"7amf" + }, { "sim":477.0, "partner":"5t3i" @@ -885179,10 +888842,6 @@ "sim":477.0, "partner":"6fll" }, - { - "sim":477.0, - "partner":"3sv5" - }, { "sim":477.0, "partner":"3svb" @@ -885201,11 +888860,11 @@ }, { "sim":477.0, - "partner":"7phr" + "partner":"3sv5" }, { "sim":477.0, - "partner":"7ssz" + "partner":"7phr" }, { "sim":477.0, @@ -885223,6 +888882,10 @@ "sim":477.0, "partner":"7ssy" }, + { + "sim":477.0, + "partner":"7ssz" + }, { "sim":476.0, "partner":"4w6b" @@ -885245,11 +888908,11 @@ }, { "sim":476.0, - "partner":"1hcj" + "partner":"2dug" }, { "sim":476.0, - "partner":"2dug" + "partner":"1hcj" }, { "sim":476.0, @@ -885287,10 +888950,6 @@ "sim":476.0, "partner":"3ss0" }, - { - "sim":476.0, - "partner":"7bym" - }, { "sim":476.0, "partner":"7byn" @@ -885300,8 +888959,8 @@ "partner":"7byl" }, { - "sim":475.0, - "partner":"1rmo" + "sim":476.0, + "partner":"7bym" }, { "sim":475.0, @@ -885315,6 +888974,10 @@ "sim":475.0, "partner":"2duf" }, + { + "sim":475.0, + "partner":"1rmo" + }, { "sim":475.0, "partner":"1emc" @@ -885367,10 +889030,6 @@ "sim":475.0, "partner":"3cbe" }, - { - "sim":475.0, - "partner":"8am4" - }, { "sim":475.0, "partner":"8a6n" @@ -885403,17 +889062,13 @@ "sim":475.0, "partner":"8a6q" }, - { - "sim":475.0, - "partner":"8a6r" - }, { "sim":475.0, "partner":"6t39" }, { "sim":475.0, - "partner":"8a6s" + "partner":"8a6r" }, { "sim":475.0, @@ -885421,12 +889076,16 @@ }, { "sim":475.0, - "partner":"8a83" + "partner":"8a6s" }, { "sim":475.0, "partner":"6pfr" }, + { + "sim":475.0, + "partner":"8a83" + }, { "sim":475.0, "partner":"6pfs" @@ -885443,6 +889102,10 @@ "sim":475.0, "partner":"8a6g" }, + { + "sim":475.0, + "partner":"8am4" + }, { "sim":475.0, "partner":"4pfe" @@ -885473,31 +889136,31 @@ }, { "sim":474.0, - "partner":"1jby" + "partner":"8jl2" }, { "sim":474.0, - "partner":"1jbz" + "partner":"8jkc" }, { "sim":474.0, - "partner":"1jc0" + "partner":"8jkg" }, { "sim":474.0, - "partner":"8jl2" + "partner":"1jby" }, { "sim":474.0, - "partner":"1jc1" + "partner":"1jbz" }, { "sim":474.0, - "partner":"8jkc" + "partner":"1jc0" }, { "sim":474.0, - "partner":"8jkg" + "partner":"1jc1" }, { "sim":474.0, @@ -885525,15 +889188,15 @@ }, { "sim":473.0, - "partner":"2dui" + "partner":"4ka9" }, { "sim":473.0, - "partner":"4ka9" + "partner":"4kex" }, { "sim":473.0, - "partner":"4kex" + "partner":"2dui" }, { "sim":473.0, @@ -885541,11 +889204,11 @@ }, { "sim":473.0, - "partner":"7o7h" + "partner":"7amu" }, { "sim":473.0, - "partner":"7amu" + "partner":"7o7h" }, { "sim":473.0, @@ -885575,14 +889238,6 @@ "sim":473.0, "partner":"3v3d" }, - { - "sim":473.0, - "partner":"7a7q" - }, - { - "sim":473.0, - "partner":"7a7r" - }, { "sim":473.0, "partner":"7a7s" @@ -885607,6 +889262,14 @@ "sim":473.0, "partner":"7a7l" }, + { + "sim":473.0, + "partner":"7a7q" + }, + { + "sim":473.0, + "partner":"7a7r" + }, { "sim":473.0, "partner":"6uhj" @@ -885673,19 +889336,19 @@ }, { "sim":471.0, - "partner":"1f09" + "partner":"2yfp" }, { "sim":471.0, - "partner":"2yfp" + "partner":"1f09" }, { "sim":471.0, - "partner":"1f0b" + "partner":"8jl5" }, { "sim":471.0, - "partner":"8jl5" + "partner":"1f0b" }, { "sim":471.0, @@ -885709,19 +889372,19 @@ }, { "sim":471.0, - "partner":"4h47" + "partner":"6qq8" }, { "sim":471.0, - "partner":"4h48" + "partner":"4h47" }, { "sim":471.0, - "partner":"6qq8" + "partner":"6qq9" }, { "sim":471.0, - "partner":"6qq9" + "partner":"4h48" }, { "sim":471.0, @@ -885783,18 +889446,6 @@ "sim":470.0, "partner":"4kw4" }, - { - "sim":470.0, - "partner":"3dqc" - }, - { - "sim":470.0, - "partner":"3dqd" - }, - { - "sim":470.0, - "partner":"3dqe" - }, { "sim":470.0, "partner":"3dqf" @@ -885887,6 +889538,18 @@ "sim":470.0, "partner":"3dqa" }, + { + "sim":470.0, + "partner":"3dqc" + }, + { + "sim":470.0, + "partner":"3dqd" + }, + { + "sim":470.0, + "partner":"3dqe" + }, { "sim":470.0, "partner":"6zqo" @@ -886169,11 +889832,11 @@ }, { "sim":458.0, - "partner":"1rmp" + "partner":"1rmm" }, { "sim":458.0, - "partner":"1rmm" + "partner":"1rmp" }, { "sim":458.0, @@ -886259,10 +889922,6 @@ "sim":448.0, "partner":"4rtc" }, - { - "sim":447.0, - "partner":"4w6m" - }, { "sim":447.0, "partner":"4w6n" @@ -886287,6 +889946,10 @@ "sim":447.0, "partner":"4w6l" }, + { + "sim":447.0, + "partner":"4w6m" + }, { "sim":446.0, "partner":"4w6p" @@ -886439,10 +890102,6 @@ "sim":422.0, "partner":"7lg4" }, - { - "sim":422.0, - "partner":"6wvi" - }, { "sim":422.0, "partner":"6wv8" @@ -886459,6 +890118,10 @@ "sim":422.0, "partner":"6wvb" }, + { + "sim":422.0, + "partner":"6wvi" + }, { "sim":418.0, "partner":"8p6g" @@ -886687,14 +890350,6 @@ "sim":301.0, "partner":"7st4" }, - { - "sim":301.0, - "partner":"3sg5" - }, - { - "sim":301.0, - "partner":"3sg7" - }, { "sim":301.0, "partner":"4ik8" @@ -886727,6 +890382,14 @@ "sim":301.0, "partner":"4ik4" }, + { + "sim":301.0, + "partner":"3sg5" + }, + { + "sim":301.0, + "partner":"3sg7" + }, { "sim":301.0, "partner":"3ek7" @@ -886777,15 +890440,15 @@ }, { "sim":296.0, - "partner":"6ya9" + "partner":"6zsm" }, { "sim":296.0, - "partner":"6zsm" + "partner":"6zsn" }, { "sim":296.0, - "partner":"6zsn" + "partner":"6ya9" }, { "sim":296.0, @@ -886841,11 +890504,11 @@ }, { "sim":136.0, - "partner":"6j1a" + "partner":"6jxf" }, { "sim":136.0, - "partner":"6jxf" + "partner":"6j1a" }, { "sim":133.0, @@ -886897,7 +890560,7 @@ }, { "sim":110.0, - "partner":"7y40" + "partner":"8j3j" }, { "sim":110.0, @@ -886905,7 +890568,7 @@ }, { "sim":110.0, - "partner":"8j3j" + "partner":"7y40" }, { "sim":110.0, @@ -886929,27 +890592,27 @@ }, { "sim":109.0, - "partner":"8j2h" + "partner":"8j2l" }, { "sim":109.0, - "partner":"8gyf" + "partner":"7yre" }, { "sim":109.0, - "partner":"8j2j" + "partner":"8j2h" }, { "sim":109.0, - "partner":"8j2k" + "partner":"8gyf" }, { "sim":109.0, - "partner":"8j2l" + "partner":"8j2j" }, { "sim":109.0, - "partner":"7yre" + "partner":"8j2k" }, { "sim":108.0, @@ -886989,11 +890652,11 @@ }, { "sim":107.0, - "partner":"8k9t" + "partner":"8k9r" }, { "sim":107.0, - "partner":"8k9r" + "partner":"8k9t" }, { "sim":106.0, @@ -887081,11 +890744,11 @@ }, { "sim":102.0, - "partner":"2vvi" + "partner":"2vvh" }, { "sim":102.0, - "partner":"2vvh" + "partner":"2vvi" }, { "sim":102.0, @@ -887131,10 +890794,6 @@ "sim":102.0, "partner":"2h5q" }, - { - "sim":102.0, - "partner":"8ilx" - }, { "sim":102.0, "partner":"8im0" @@ -887147,6 +890806,10 @@ "sim":102.0, "partner":"6ir1" }, + { + "sim":102.0, + "partner":"8ilx" + }, { "sim":102.0, "partner":"7saj" @@ -887217,51 +890880,51 @@ }, { "sim":101.0, - "partner":"7qlk" + "partner":"7qlo" }, { "sim":101.0, - "partner":"8ul2" + "partner":"8ul1" }, { "sim":101.0, - "partner":"7qll" + "partner":"8ul2" }, { "sim":101.0, - "partner":"7qlm" + "partner":"8ul3" }, { "sim":101.0, - "partner":"8ul3" + "partner":"8ul4" }, { "sim":101.0, - "partner":"7qln" + "partner":"8ul5" }, { "sim":101.0, - "partner":"7qlo" + "partner":"7qli" }, { "sim":101.0, - "partner":"8ul4" + "partner":"7qlj" }, { "sim":101.0, - "partner":"8ul5" + "partner":"7qlk" }, { "sim":101.0, - "partner":"7qli" + "partner":"7qll" }, { "sim":101.0, - "partner":"8ul1" + "partner":"7qlm" }, { "sim":101.0, - "partner":"7qlj" + "partner":"7qln" }, { "sim":101.0, @@ -887373,11 +891036,11 @@ }, { "sim":98.0, - "partner":"8wgp" + "partner":"2vad" }, { "sim":98.0, - "partner":"2vad" + "partner":"8wgp" }, { "sim":98.0, @@ -887417,11 +891080,11 @@ }, { "sim":96.0, - "partner":"6qsl" + "partner":"8ul0" }, { "sim":96.0, - "partner":"4q9w" + "partner":"6qsl" }, { "sim":96.0, @@ -887429,7 +891092,7 @@ }, { "sim":96.0, - "partner":"4q9x" + "partner":"4q9w" }, { "sim":96.0, @@ -887437,7 +891100,7 @@ }, { "sim":96.0, - "partner":"8ul0" + "partner":"4q9x" }, { "sim":96.0, @@ -887453,11 +891116,11 @@ }, { "sim":96.0, - "partner":"3nf0" + "partner":"4h3n" }, { "sim":96.0, - "partner":"4h3n" + "partner":"3nf0" }, { "sim":96.0, @@ -887499,10 +891162,6 @@ "sim":94.0, "partner":"4q7r" }, - { - "sim":94.0, - "partner":"7rrj" - }, { "sim":94.0, "partner":"7rrk" @@ -887515,6 +891174,10 @@ "sim":94.0, "partner":"7rri" }, + { + "sim":94.0, + "partner":"7rrj" + }, { "sim":94.0, "partner":"6d38" @@ -887533,11 +891196,11 @@ }, { "sim":93.0, - "partner":"4tzg" + "partner":"4ppk" }, { "sim":93.0, - "partner":"4ppk" + "partner":"4tzg" }, { "sim":93.0, @@ -887605,15 +891268,15 @@ }, { "sim":90.0, - "partner":"5hzt" + "partner":"5hzu" }, { "sim":90.0, - "partner":"5hzu" + "partner":"5hzs" }, { "sim":90.0, - "partner":"5hzs" + "partner":"5hzt" }, { "sim":90.0, @@ -887707,14 +891370,6 @@ "sim":88.0, "partner":"8pei" }, - { - "sim":88.0, - "partner":"6nqn" - }, - { - "sim":88.0, - "partner":"6nqr" - }, { "sim":88.0, "partner":"6nqo" @@ -887743,6 +891398,14 @@ "sim":88.0, "partner":"6nqq" }, + { + "sim":88.0, + "partner":"6nqn" + }, + { + "sim":88.0, + "partner":"6nqr" + }, { "sim":88.0, "partner":"2z6x" @@ -887773,11 +891436,11 @@ }, { "sim":86.0, - "partner":"3mgf" + "partner":"6xwy" }, { "sim":86.0, - "partner":"6xwy" + "partner":"3mgf" }, { "sim":86.0, @@ -887933,15 +891596,15 @@ }, { "sim":82.0, - "partner":"8i4j" + "partner":"2ddc" }, { "sim":82.0, - "partner":"2ddc" + "partner":"2ddd" }, { "sim":82.0, - "partner":"2ddd" + "partner":"8i4j" }, { "sim":82.0, @@ -887953,11 +891616,11 @@ }, { "sim":81.0, - "partner":"1ggx" + "partner":"1zgo" }, { "sim":81.0, - "partner":"1zgo" + "partner":"1ggx" }, { "sim":81.0, @@ -888021,11 +891684,11 @@ }, { "sim":79.0, - "partner":"3e5v" + "partner":"3e5w" }, { "sim":79.0, - "partner":"3e5w" + "partner":"3e5v" }, { "sim":78.0, @@ -888071,10 +891734,6 @@ "sim":76.0, "partner":"4eds" }, - { - "sim":76.0, - "partner":"3bxc" - }, { "sim":76.0, "partner":"3bx9" @@ -888087,6 +891746,10 @@ "sim":76.0, "partner":"3bxb" }, + { + "sim":76.0, + "partner":"3bxc" + }, { "sim":74.0, "partner":"3pjb" @@ -888155,17 +891818,13 @@ "sim":72.0, "partner":"3pj7" }, - { - "sim":72.0, - "partner":"3h1o" - }, { "sim":72.0, "partner":"3h1r" }, { "sim":72.0, - "partner":"4nws" + "partner":"3h1o" }, { "sim":72.0, @@ -888187,6 +891846,10 @@ "sim":72.0, "partner":"3nt9" }, + { + "sim":72.0, + "partner":"4nws" + }, { "sim":71.0, "partner":"2vvj" @@ -888277,15 +891940,15 @@ }, { "sim":65.0, - "partner":"7z7p" + "partner":"7z7q" }, { "sim":65.0, - "partner":"7z7q" + "partner":"7z7o" }, { "sim":65.0, - "partner":"7z7o" + "partner":"7z7p" }, { "sim":64.0, @@ -888339,10 +892002,6 @@ "sim":55.0, "partner":"7sf9" }, - { - "sim":54.0, - "partner":"2a53" - }, { "sim":54.0, "partner":"2a54" @@ -888363,6 +892022,10 @@ "sim":54.0, "partner":"2a52" }, + { + "sim":54.0, + "partner":"2a53" + }, { "sim":53.0, "partner":"3u0k" @@ -888377,11 +892040,11 @@ }, { "sim":50.0, - "partner":"2g6x" + "partner":"2g6y" }, { "sim":50.0, - "partner":"2g6y" + "partner":"2g6x" } ], "struct_thr_sim_designed":[ @@ -888474,93 +892137,93 @@ ], "subtitle":"T33-ml23 - designed tetrahedral protein cage using machine learning algorithms", "tags":[ + "machine learning", + "tetrahedral", + "de novo protein", "two components", - "nanohedra", - "nanoparticle", + "proteinmpnn", "de novo protein interface", "protein cage", - "de novo protein", - "tetrahedral", - "proteinmpnn", - "machine learning" + "nanoparticle", + "nanohedra" ], "keywords":[ - "analysis", - "intermediate", - "available", - "including", - "substantially", - "designed", - "provide", + "learning", + "insights", + "resolution", + "polarity", + "experimental", + "tetrahedrally", + "machine", + "protein", + "increased", "identifying", + "novo", + "contact", + "motifs", + "power", + "body", + "two", + "applications", + "related", "outcomes", - "insights", "biotechnology", - "body", - "conformations", - "hydrophobicity", - "power", - "seven", - "reaching", - "unique", - "de", - "\u00e5", - "nanoparticles", + "using", + "highest", + "creation", + "opportunities", "medicine", - "remains", - "interface", - "materials", - "symmetric", - "improving", - "structures", - "motifs", - "achieved", - "highlights", - "generation", - "tetrahedrally", - "assemblies", - "methodologies", - "report", - "contact", - "resolution", - "increased", - "challenging", "adds", - "approaches", - "cages", - "polarity", - "provides", - "comparison", - "design", - "suite", - "using", - "applications", - "sequence", - "learning", - "machine", - "protocols", - "proteinmpnn", - "patterns", + "polar", "approach", - "novo", + "achieved", + "balancing", "success", - "highest", - "emphasize", - "prioritizing", - "experimental", + "interface", + "available", "along", + "computational", + "including", + "proteinmpnn", + "set", + "challenging", + "design", "preferred", + "provides", + "nanoparticles", + "highlights", + "suite", + "prioritizing", "apply", - "two", - "polar", - "set", - "creation", - "protein", - "balancing", + "hydrophobicity", + "symmetric", + "cages", + "methodologies", + "sequence", + "substantially", "docked", - "computational", - "opportunities", - "related", + "unique", + "assemblies", + "materials", + "reaching", + "designed", + "analysis", + "generation", + "improving", + "de", + "structures", + "approaches", + "remains", + "\u00e5", + "emphasize", + "report", + "provide", + "patterns", + "intermediate", + "seven", + "protocols", + "conformations", + "comparison", "five" ], "release_date":"2023-11-15", @@ -888600,14 +892263,6 @@ "sim":270.0, "partner":"8ui2" }, - { - "sim":66.0, - "partner":"8umr" - }, - { - "sim":66.0, - "partner":"8ump" - }, { "sim":232.0, "partner":"8ukm" @@ -888615,41 +892270,17 @@ { "sim":113.0, "partner":"8t6n" - } - ], - "seq_thr_sim_natural":[ - { - "sim":72.0, - "partner":"4iyq" - }, - { - "sim":67.0, - "partner":"1v6h" - }, - { - "sim":67.0, - "partner":"1nza" - }, - { - "sim":60.0, - "partner":"1osc" - }, - { - "sim":57.0, - "partner":"1xk8" - }, - { - "sim":57.0, - "partner":"2zfh" }, { - "sim":53.0, - "partner":"7l85" + "sim":66.0, + "partner":"8ump" }, { - "sim":53.0, - "partner":"4zk7" - }, + "sim":66.0, + "partner":"8umr" + } + ], + "seq_thr_sim_natural":[ { "sim":162.0, "partner":"6n06" @@ -888693,6 +892324,38 @@ { "sim":87.0, "partner":"6fdb" + }, + { + "sim":72.0, + "partner":"4iyq" + }, + { + "sim":67.0, + "partner":"1v6h" + }, + { + "sim":67.0, + "partner":"1nza" + }, + { + "sim":60.0, + "partner":"1osc" + }, + { + "sim":57.0, + "partner":"1xk8" + }, + { + "sim":57.0, + "partner":"2zfh" + }, + { + "sim":53.0, + "partner":"7l85" + }, + { + "sim":53.0, + "partner":"4zk7" } ], "struct_thr_sim_designed":[ @@ -888794,86 +892457,86 @@ "de novo design" ], "keywords":[ + "templates", "largely", - "calcite", - "unknown", - "providing", - "bypassed", - "thus", - "nanocrystals", - "route", - "ions", + "molecular", + "repeat", "spaced", - "test", - "designed", - "polymorph", - "programmed", - "carbonate", + "tuned", + "mineralization", + "route", "mesocrystals", - "110", - "find", - "structure", - "repeat", - "interfaces", - "structured", - "proteins", - "hypothesized", - "remain", - "vaterite", - "de", - "modulate", - "materials", - "regularly", - "assemble", - "oriented", - "arrays", - "templates", - "atomic", + "protein", "nanocrystal", - "hierarchically", - "size", - "attachment", - "achieved", - "first", - "crystallization", - "monomers", - "molecular", - "regulate", - "directly", - "nucleation", - "dhrs", - "assemblies", - "flat", - "generate", - "hypothesis", - "template", - "carboxylate", - "surfaces", - "faces", - "design", "helical", + "biomolecules", + "novo", + "test", + "forms", + "dhrs", + "unknown", "using", - "surface", - "nucleate", - "could", - "heterogeneous", - "202", "supramolecular", "chemistry", - "inorganic", - "novo", + "heterogeneous", + "oriented", + "faces", + "thus", + "carboxylate", + "surfaces", + "202", + "proteins", + "achieved", + "ions", + "size", + "modulate", + "hypothesis", + "regulate", + "polymorph", + "surface", + "design", + "atomic", "length", + "nanocrystals", + "absence", + "monomers", + "template", + "attachment", + "calcite", + "inorganic", + "varying", "hybrid", + "assemblies", + "materials", + "could", + "hierarchically", + "directly", + "designed", + "regularly", "displaying", - "biomolecules", - "absence", - "tuned", - "mineralization", - "protein", "biominerals", - "varying", + "interfaces", "calcium", - "forms" + "nucleate", + "bypassed", + "providing", + "de", + "carbonate", + "first", + "crystallization", + "structured", + "structure", + "110", + "nucleation", + "flat", + "programmed", + "find", + "arrays", + "remain", + "assemble", + "vaterite", + "generate", + "hypothesized" ], "release_date":"2023-12-27", "publication":"\"Directing polymorph specific calcium carbonate formation with de novo protein templates\", Nat Commun, 14, 8191-8191", @@ -888999,93 +892662,93 @@ ], "subtitle":"T33-ml28 - designed tetrahedral protein cage using machine learning algorithms", "tags":[ + "machine learning", + "tetrahedral", + "de novo protein", "two components", - "nanohedra", - "nanoparticle", + "proteinmpnn", "de novo protein interface", "protein cage", - "de novo protein", - "tetrahedral", - "proteinmpnn", - "machine learning" + "nanoparticle", + "nanohedra" ], "keywords":[ - "analysis", - "intermediate", - "available", - "including", - "substantially", - "designed", - "provide", + "learning", + "insights", + "resolution", + "polarity", + "experimental", + "tetrahedrally", + "machine", + "protein", + "increased", "identifying", + "novo", + "contact", + "motifs", + "power", + "body", + "two", + "applications", + "related", "outcomes", - "insights", "biotechnology", - "body", - "conformations", - "hydrophobicity", - "power", - "seven", - "reaching", - "unique", - "de", - "\u00e5", - "nanoparticles", + "using", + "highest", + "creation", + "opportunities", "medicine", - "remains", - "interface", - "materials", - "symmetric", - "improving", - "structures", - "motifs", - "achieved", - "highlights", - "generation", - "tetrahedrally", - "assemblies", - "methodologies", - "report", - "contact", - "resolution", - "increased", - "challenging", "adds", - "approaches", - "cages", - "polarity", - "provides", - "comparison", - "design", - "suite", - "using", - "applications", - "sequence", - "learning", - "machine", - "protocols", - "proteinmpnn", - "patterns", + "polar", "approach", - "novo", + "achieved", + "balancing", "success", - "highest", - "emphasize", - "prioritizing", - "experimental", + "interface", + "available", "along", + "computational", + "including", + "proteinmpnn", + "set", + "challenging", + "design", "preferred", + "provides", + "nanoparticles", + "highlights", + "suite", + "prioritizing", "apply", - "two", - "polar", - "set", - "creation", - "protein", - "balancing", + "hydrophobicity", + "symmetric", + "cages", + "methodologies", + "sequence", + "substantially", "docked", - "computational", - "opportunities", - "related", + "unique", + "assemblies", + "materials", + "reaching", + "designed", + "analysis", + "generation", + "improving", + "de", + "structures", + "approaches", + "remains", + "\u00e5", + "emphasize", + "report", + "provide", + "patterns", + "intermediate", + "seven", + "protocols", + "conformations", + "comparison", "five" ], "release_date":"2024-03-06", @@ -889121,28 +892784,56 @@ "sim":278.0, "partner":"8uf0" }, + { + "sim":248.0, + "partner":"8ukm" + }, { "sim":242.0, "partner":"8un1" }, { - "sim":63.0, - "partner":"8umr" + "sim":121.0, + "partner":"8t6n" }, { "sim":63.0, "partner":"8ump" }, { - "sim":248.0, - "partner":"8ukm" - }, - { - "sim":121.0, - "partner":"8t6n" + "sim":63.0, + "partner":"8umr" } ], "seq_thr_sim_natural":[ + { + "sim":91.0, + "partner":"6t76" + }, + { + "sim":91.0, + "partner":"6t7e" + }, + { + "sim":59.0, + "partner":"1v6h" + }, + { + "sim":59.0, + "partner":"1nza" + }, + { + "sim":52.0, + "partner":"1xk8" + }, + { + "sim":52.0, + "partner":"2zfh" + }, + { + "sim":50.0, + "partner":"4zk7" + }, { "sim":159.0, "partner":"6n06" @@ -889198,34 +892889,6 @@ { "sim":50.0, "partner":"7mmx" - }, - { - "sim":91.0, - "partner":"6t7e" - }, - { - "sim":91.0, - "partner":"6t76" - }, - { - "sim":59.0, - "partner":"1v6h" - }, - { - "sim":59.0, - "partner":"1nza" - }, - { - "sim":52.0, - "partner":"1xk8" - }, - { - "sim":52.0, - "partner":"2zfh" - }, - { - "sim":50.0, - "partner":"4zk7" } ], "struct_thr_sim_designed":[ @@ -889318,93 +892981,93 @@ ], "subtitle":"T33-ml30 - designed tetrahedral protein cage using machine learning algorithms", "tags":[ + "machine learning", + "tetrahedral", + "de novo protein", "two components", - "nanohedra", - "nanoparticle", + "proteinmpnn", "de novo protein interface", "protein cage", - "de novo protein", - "tetrahedral", - "proteinmpnn", - "machine learning" + "nanoparticle", + "nanohedra" ], "keywords":[ - "analysis", - "intermediate", - "available", - "including", - "substantially", - "designed", - "provide", + "learning", + "insights", + "resolution", + "polarity", + "experimental", + "tetrahedrally", + "machine", + "protein", + "increased", "identifying", + "novo", + "contact", + "motifs", + "power", + "body", + "two", + "applications", + "related", "outcomes", - "insights", "biotechnology", - "body", - "conformations", - "hydrophobicity", - "power", - "seven", - "reaching", - "unique", - "de", - "\u00e5", - "nanoparticles", + "using", + "highest", + "creation", + "opportunities", "medicine", - "remains", - "interface", - "materials", - "symmetric", - "improving", - "structures", - "motifs", - "achieved", - "highlights", - "generation", - "tetrahedrally", - "assemblies", - "methodologies", - "report", - "contact", - "resolution", - "increased", - "challenging", "adds", - "approaches", - "cages", - "polarity", - "provides", - "comparison", - "design", - "suite", - "using", - "applications", - "sequence", - "learning", - "machine", - "protocols", - "proteinmpnn", - "patterns", + "polar", "approach", - "novo", + "achieved", + "balancing", "success", - "highest", - "emphasize", - "prioritizing", - "experimental", + "interface", + "available", "along", + "computational", + "including", + "proteinmpnn", + "set", + "challenging", + "design", "preferred", + "provides", + "nanoparticles", + "highlights", + "suite", + "prioritizing", "apply", - "two", - "polar", - "set", - "creation", - "protein", - "balancing", + "hydrophobicity", + "symmetric", + "cages", + "methodologies", + "sequence", + "substantially", "docked", - "computational", - "opportunities", - "related", + "unique", + "assemblies", + "materials", + "reaching", + "designed", + "analysis", + "generation", + "improving", + "de", + "structures", + "approaches", + "remains", + "\u00e5", + "emphasize", + "report", + "provide", + "patterns", + "intermediate", + "seven", + "protocols", + "conformations", + "comparison", "five" ], "release_date":"2024-03-06", @@ -889645,93 +893308,93 @@ ], "subtitle":"T33-ml35 - designed tetrahedral protein cage using machine learning algorithms", "tags":[ + "machine learning", + "tetrahedral", + "de novo protein", "two components", - "nanohedra", - "nanoparticle", + "proteinmpnn", "de novo protein interface", "protein cage", - "de novo protein", - "tetrahedral", - "proteinmpnn", - "machine learning" + "nanoparticle", + "nanohedra" ], "keywords":[ - "analysis", - "intermediate", - "available", - "including", - "substantially", - "designed", - "provide", + "learning", + "insights", + "resolution", + "polarity", + "experimental", + "tetrahedrally", + "machine", + "protein", + "increased", "identifying", + "novo", + "contact", + "motifs", + "power", + "body", + "two", + "applications", + "related", "outcomes", - "insights", "biotechnology", - "body", - "conformations", - "hydrophobicity", - "power", - "seven", - "reaching", - "unique", - "de", - "\u00e5", - "nanoparticles", + "using", + "highest", + "creation", + "opportunities", "medicine", - "remains", - "interface", - "materials", - "symmetric", - "improving", - "structures", - "motifs", - "achieved", - "highlights", - "generation", - "tetrahedrally", - "assemblies", - "methodologies", - "report", - "contact", - "resolution", - "increased", - "challenging", "adds", - "approaches", - "cages", - "polarity", - "provides", - "comparison", - "design", - "suite", - "using", - "applications", - "sequence", - "learning", - "machine", - "protocols", - "proteinmpnn", - "patterns", + "polar", "approach", - "novo", + "achieved", + "balancing", "success", - "highest", - "emphasize", - "prioritizing", - "experimental", + "interface", + "available", "along", + "computational", + "including", + "proteinmpnn", + "set", + "challenging", + "design", "preferred", + "provides", + "nanoparticles", + "highlights", + "suite", + "prioritizing", "apply", - "two", - "polar", - "set", - "creation", - "protein", - "balancing", + "hydrophobicity", + "symmetric", + "cages", + "methodologies", + "sequence", + "substantially", "docked", - "computational", - "opportunities", - "related", + "unique", + "assemblies", + "materials", + "reaching", + "designed", + "analysis", + "generation", + "improving", + "de", + "structures", + "approaches", + "remains", + "\u00e5", + "emphasize", + "report", + "provide", + "patterns", + "intermediate", + "seven", + "protocols", + "conformations", + "comparison", "five" ], "release_date":"2023-11-15", @@ -889767,6 +893430,18 @@ "sim":248.0, "partner":"8umr" }, + { + "sim":65.0, + "partner":"8ui2" + }, + { + "sim":63.0, + "partner":"8uf0" + }, + { + "sim":63.0, + "partner":"8un1" + }, { "sim":178.0, "partner":"5hrz" @@ -889801,11 +893476,11 @@ }, { "sim":134.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":134.0, - "partner":"8cqq" + "partner":"8cqp" }, { "sim":134.0, @@ -889813,27 +893488,27 @@ }, { "sim":134.0, - "partner":"8chy" + "partner":"8cmq" }, { "sim":134.0, - "partner":"8cmq" + "partner":"8bu0" }, { "sim":134.0, - "partner":"8ckr" + "partner":"8cp8" }, { "sim":134.0, - "partner":"8cig" + "partner":"8cqq" }, { "sim":134.0, - "partner":"8cqp" + "partner":"8chy" }, { "sim":134.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":128.0, @@ -889853,31 +893528,19 @@ }, { "sim":71.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":71.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":71.0, - "partner":"8cus" + "partner":"8cwz" }, { "sim":56.0, "partner":"6xss" - }, - { - "sim":65.0, - "partner":"8ui2" - }, - { - "sim":63.0, - "partner":"8uf0" - }, - { - "sim":63.0, - "partner":"8un1" } ], "seq_thr_sim_natural":[ @@ -889925,10 +893588,6 @@ "sim":66.0, "partner":"7y4i" }, - { - "sim":66.0, - "partner":"8dtf" - }, { "sim":66.0, "partner":"8dtg" @@ -889941,6 +893600,10 @@ "sim":66.0, "partner":"8dti" }, + { + "sim":66.0, + "partner":"8dtf" + }, { "sim":66.0, "partner":"7qdr" @@ -889975,11 +893638,11 @@ }, { "sim":55.0, - "partner":"6fdp" + "partner":"6fdt" }, { "sim":55.0, - "partner":"6fdt" + "partner":"6fdp" }, { "sim":55.0, @@ -890102,93 +893765,93 @@ ], "subtitle":"T33-ml35 assembly intermediate - designed tetrahedral protein cage using machine learning algorithms", "tags":[ + "machine learning", + "tetrahedral", + "de novo protein", "two components", - "nanohedra", - "nanoparticle", + "proteinmpnn", "de novo protein interface", "protein cage", - "de novo protein", - "tetrahedral", - "proteinmpnn", - "machine learning" + "nanoparticle", + "nanohedra" ], "keywords":[ - "analysis", - "intermediate", - "available", - "including", - "substantially", - "designed", - "provide", + "learning", + "insights", + "resolution", + "polarity", + "experimental", + "tetrahedrally", + "machine", + "protein", + "increased", "identifying", + "novo", + "contact", + "motifs", + "power", + "body", + "two", + "applications", + "related", "outcomes", - "insights", "biotechnology", - "body", - "conformations", - "hydrophobicity", - "power", - "seven", - "reaching", - "unique", - "de", - "\u00e5", - "nanoparticles", + "using", + "highest", + "creation", + "opportunities", "medicine", - "remains", - "interface", - "materials", - "symmetric", - "improving", - "structures", - "motifs", - "achieved", - "highlights", - "generation", - "tetrahedrally", - "assemblies", - "methodologies", - "report", - "contact", - "resolution", - "increased", - "challenging", "adds", - "approaches", - "cages", - "polarity", - "provides", - "comparison", - "design", - "suite", - "using", - "applications", - "sequence", - "learning", - "machine", - "protocols", - "proteinmpnn", - "patterns", + "polar", "approach", - "novo", + "achieved", + "balancing", "success", - "highest", - "emphasize", - "prioritizing", - "experimental", + "interface", + "available", "along", + "computational", + "including", + "proteinmpnn", + "set", + "challenging", + "design", "preferred", + "provides", + "nanoparticles", + "highlights", + "suite", + "prioritizing", "apply", - "two", - "polar", - "set", - "creation", - "protein", - "balancing", + "hydrophobicity", + "symmetric", + "cages", + "methodologies", + "sequence", + "substantially", "docked", - "computational", - "opportunities", - "related", + "unique", + "assemblies", + "materials", + "reaching", + "designed", + "analysis", + "generation", + "improving", + "de", + "structures", + "approaches", + "remains", + "\u00e5", + "emphasize", + "report", + "provide", + "patterns", + "intermediate", + "seven", + "protocols", + "conformations", + "comparison", "five" ], "release_date":"2024-03-06", @@ -890224,18 +893887,6 @@ "sim":248.0, "partner":"8ump" }, - { - "sim":65.0, - "partner":"8ui2" - }, - { - "sim":63.0, - "partner":"8uf0" - }, - { - "sim":63.0, - "partner":"8un1" - }, { "sim":178.0, "partner":"5hrz" @@ -890270,11 +893921,11 @@ }, { "sim":134.0, - "partner":"8bu0" + "partner":"8ckr" }, { "sim":134.0, - "partner":"8cqq" + "partner":"8cqp" }, { "sim":134.0, @@ -890282,27 +893933,27 @@ }, { "sim":134.0, - "partner":"8chy" + "partner":"8cmq" }, { "sim":134.0, - "partner":"8cmq" + "partner":"8bu0" }, { "sim":134.0, - "partner":"8ckr" + "partner":"8cp8" }, { "sim":134.0, - "partner":"8cig" + "partner":"8cqq" }, { "sim":134.0, - "partner":"8cqp" + "partner":"8chy" }, { "sim":134.0, - "partner":"8cp8" + "partner":"8cig" }, { "sim":128.0, @@ -890322,22 +893973,62 @@ }, { "sim":71.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":71.0, - "partner":"8cwz" + "partner":"8cut" }, { "sim":71.0, - "partner":"8cus" + "partner":"8cwz" }, { "sim":56.0, "partner":"6xss" + }, + { + "sim":65.0, + "partner":"8ui2" + }, + { + "sim":63.0, + "partner":"8uf0" + }, + { + "sim":63.0, + "partner":"8un1" } ], "seq_thr_sim_natural":[ + { + "sim":144.0, + "partner":"6gdu" + }, + { + "sim":144.0, + "partner":"6gdv" + }, + { + "sim":144.0, + "partner":"6gdw" + }, + { + "sim":144.0, + "partner":"6gdx" + }, + { + "sim":52.0, + "partner":"1v6h" + }, + { + "sim":52.0, + "partner":"1nza" + }, + { + "sim":51.0, + "partner":"1vhf" + }, { "sim":141.0, "partner":"8ur5" @@ -890362,10 +894053,6 @@ "sim":66.0, "partner":"7y4i" }, - { - "sim":66.0, - "partner":"8dtf" - }, { "sim":66.0, "partner":"8dtg" @@ -890378,6 +894065,10 @@ "sim":66.0, "partner":"8dti" }, + { + "sim":66.0, + "partner":"8dtf" + }, { "sim":66.0, "partner":"7qdr" @@ -890416,11 +894107,11 @@ }, { "sim":55.0, - "partner":"6fdp" + "partner":"6fdt" }, { "sim":55.0, - "partner":"6fdt" + "partner":"6fdp" }, { "sim":55.0, @@ -890429,34 +894120,6 @@ { "sim":50.0, "partner":"1elw" - }, - { - "sim":144.0, - "partner":"6gdu" - }, - { - "sim":144.0, - "partner":"6gdv" - }, - { - "sim":144.0, - "partner":"6gdw" - }, - { - "sim":144.0, - "partner":"6gdx" - }, - { - "sim":52.0, - "partner":"1v6h" - }, - { - "sim":52.0, - "partner":"1nza" - }, - { - "sim":51.0, - "partner":"1vhf" } ], "struct_thr_sim_designed":[ @@ -890547,93 +894210,93 @@ ], "subtitle":"T33-ml23 assembly intermediate - designed tetrahedral protein cage using machine learning algorithms", "tags":[ + "machine learning", + "tetrahedral", + "de novo protein", "two components", - "nanohedra", - "nanoparticle", + "proteinmpnn", "de novo protein interface", "protein cage", - "de novo protein", - "tetrahedral", - "proteinmpnn", - "machine learning" + "nanoparticle", + "nanohedra" ], "keywords":[ - "analysis", - "intermediate", - "available", - "including", - "substantially", - "designed", - "provide", + "learning", + "insights", + "resolution", + "polarity", + "experimental", + "tetrahedrally", + "machine", + "protein", + "increased", "identifying", + "novo", + "contact", + "motifs", + "power", + "body", + "two", + "applications", + "related", "outcomes", - "insights", "biotechnology", - "body", - "conformations", - "hydrophobicity", - "power", - "seven", - "reaching", - "unique", - "de", - "\u00e5", - "nanoparticles", + "using", + "highest", + "creation", + "opportunities", "medicine", - "remains", - "interface", - "materials", - "symmetric", - "improving", - "structures", - "motifs", - "achieved", - "highlights", - "generation", - "tetrahedrally", - "assemblies", - "methodologies", - "report", - "contact", - "resolution", - "increased", - "challenging", "adds", - "approaches", - "cages", - "polarity", - "provides", - "comparison", - "design", - "suite", - "using", - "applications", - "sequence", - "learning", - "machine", - "protocols", - "proteinmpnn", - "patterns", + "polar", "approach", - "novo", + "achieved", + "balancing", "success", - "highest", - "emphasize", - "prioritizing", - "experimental", + "interface", + "available", "along", + "computational", + "including", + "proteinmpnn", + "set", + "challenging", + "design", "preferred", + "provides", + "nanoparticles", + "highlights", + "suite", + "prioritizing", "apply", - "two", - "polar", - "set", - "creation", - "protein", - "balancing", + "hydrophobicity", + "symmetric", + "cages", + "methodologies", + "sequence", + "substantially", "docked", - "computational", - "opportunities", - "related", + "unique", + "assemblies", + "materials", + "reaching", + "designed", + "analysis", + "generation", + "improving", + "de", + "structures", + "approaches", + "remains", + "\u00e5", + "emphasize", + "report", + "provide", + "patterns", + "intermediate", + "seven", + "protocols", + "conformations", + "comparison", "five" ], "release_date":"2024-03-06", @@ -890675,11 +894338,11 @@ }, { "sim":66.0, - "partner":"8umr" + "partner":"8ump" }, { "sim":66.0, - "partner":"8ump" + "partner":"8umr" }, { "sim":232.0, @@ -890691,38 +894354,6 @@ } ], "seq_thr_sim_natural":[ - { - "sim":72.0, - "partner":"4iyq" - }, - { - "sim":67.0, - "partner":"1v6h" - }, - { - "sim":67.0, - "partner":"1nza" - }, - { - "sim":60.0, - "partner":"1osc" - }, - { - "sim":57.0, - "partner":"1xk8" - }, - { - "sim":57.0, - "partner":"2zfh" - }, - { - "sim":53.0, - "partner":"7l85" - }, - { - "sim":53.0, - "partner":"4zk7" - }, { "sim":160.0, "partner":"6n06" @@ -890766,6 +894397,38 @@ { "sim":87.0, "partner":"6fdb" + }, + { + "sim":72.0, + "partner":"4iyq" + }, + { + "sim":67.0, + "partner":"1v6h" + }, + { + "sim":67.0, + "partner":"1nza" + }, + { + "sim":60.0, + "partner":"1osc" + }, + { + "sim":57.0, + "partner":"1xk8" + }, + { + "sim":57.0, + "partner":"2zfh" + }, + { + "sim":53.0, + "partner":"7l85" + }, + { + "sim":53.0, + "partner":"4zk7" } ], "struct_thr_sim_designed":[ @@ -890832,89 +894495,89 @@ ], "subtitle":"Solution conformations of a 12-mer peptide bearing a natural n-hydrophobic triangle", "tags":[ - "protein binding", - "hydrophobic triangle" + "hydrophobic triangle", + "protein binding" ], "keywords":[ - "synthetically", - "many", - "joining", - "biased", - "intramolecular", - "uses", - "broad", - "potentially", - "towards", - "ii", + "hydrophobic", + "structural", + "exclusively", "show", - "interactions", - "synthetic", - "validate", - "structure", - "aspartic", - "database", - "community", - "novel", - "conformations", - "develop", - "perturb", + "trends", + "side", + "comprise", + "via", + "canonical", "ppis", - "testing", - "unique", - "inducing", + "bicyclic", + "perturb", + "protein", + "study", + "probes", "linear", - "disruption", - "interface", + "helical", + "following", + "comprising", "motif", - "nature", - "exclusively", - "searchable", - "natural", - "capping", "motifs", - "heavily", - "powerful", - "following", - "via", - "bamms", - "bicyclic", - "triangles", - "acids", - "fragments", - "useful", - "iii", - "biomimetic", - "canonical", - "provides", - "observed", - "asx", - "helical", - "using", - "hydrophobic", + "potentially", + "two", "secondary", - "effect", - "stapling", - "stabilized", - "comprise", - "structural", - "mimics", + "disruption", "chains", - "accessible", + "using", + "bamms", + "stapling", + "creation", "mimicry", - "study", - "peptides", - "residues", - "two", + "biased", + "effect", + "accessible", "comprises", + "residues", + "helix", + "useful", + "develop", + "broad", + "joining", + "iii", + "intramolecular", + "interface", + "inducing", "studying", - "creation", - "protein", + "heavily", + "aspartic", + "provides", + "natural", + "testing", "section", - "helix", - "trends", - "comprising", - "side", - "probes" + "asx", + "validate", + "uses", + "peptides", + "triangles", + "unique", + "synthetically", + "many", + "community", + "observed", + "fragments", + "structure", + "synthetic", + "powerful", + "interactions", + "nature", + "capping", + "biomimetic", + "mimics", + "towards", + "acids", + "conformations", + "database", + "searchable", + "stabilized", + "novel", + "ii" ], "release_date":"2024-06-05", "publication":"\"Bioinformatics leading to conveniently accessible, helix enforcing, bicyclic ASX motif mimics (BAMMs)\", Nat Commun, 15, 4217-4217", @@ -891085,96 +894748,96 @@ ], "subtitle":"Designed il-1r antagonist il-1rmb80", "tags":[ - "antagonist", "de novo protein", + "protein design", "immune system", - "protein design" + "antagonist" ], "keywords":[ - "hence", - "long", - "studies", - "mitigate", - "signaling", - "crystallography", - "designed", - "receptor", + "treatments", + "disease", + "key", + "show", + "minibinders", + "via", + "cardiac", + "model", + "damage", + "protective", + "protein", + "binding", "syndrome", + "novo", + "storm", + "match", + "inflammatory", + "antagonists", + "promise", "induced", - "current", - "target", - "show", + "global", + "effects", + "involved", + "cytokines", + "receptor", + "administration", + "interacting", + "due", + "crs", + "targets", + "release", "bind", + "response", + "proteins", + "small", + "subunits", + "long", + "computational", + "cytokine", + "activate", + "localized", + "critical", + "design", + "signaling", + "current", + "mitigate", + "hence", "health", - "therapeutic", - "disease", - "protective", "acute", - "inflammatory", + "prevent", + "therapeutic", + "anakinra", + "commonly", + "systemic", "inflammation", - "proteins", + "demonstrated", + "present", + "range", + "reveal", + "designed", + "organoid", "models", "receptors", - "cytokines", - "de", - "involved", - "response", - "anakinra", - "less", - "small", - "threat", - "picomolar", - "match", "structures", + "de", "suitable", - "effects", - "cardiac", - "activate", - "administration", - "prevent", - "minibinders", - "demonstrated", "injection", - "making", - "cytokine", - "via", - "release", - "damage", "gp130", - "limitations", - "interacting", "closely", - "design", - "model", - "commonly", - "promise", - "present", + "target", + "crystallography", + "known", + "making", + "threat", "routes", "tocilizumab", - "antagonists", - "subunits", - "treatments", - "key", - "systemic", - "known", - "range", - "localized", - "critical", - "storm", - "novo", + "picomolar", + "studies", + "limitations", "human", - "reveal", "affinities", - "due", + "less", "subcutaneous", - "significant", - "protein", - "organoid", - "targets", - "computational", - "global", - "binding", - "crs" + "significant" ], "release_date":"2024-08-28", "publication":"\"De novo design of miniprotein antagonists of cytokine storm inducers\", Nat Commun, 15, 7064-7064", @@ -891356,95 +895019,95 @@ ], "subtitle":"Structure of gp130 in complex with a de novo designed il-6 mimetic", "tags":[ - "cytokine", "cytokine receptor", - "de novo design" + "de novo design", + "cytokine" ], "keywords":[ - "hence", - "long", - "studies", - "mitigate", - "signaling", - "crystallography", - "designed", - "receptor", + "treatments", + "disease", + "key", + "show", + "minibinders", + "via", + "cardiac", + "model", + "damage", + "protective", + "protein", + "binding", "syndrome", + "novo", + "storm", + "match", + "inflammatory", + "antagonists", + "promise", "induced", - "current", - "target", - "show", + "global", + "effects", + "involved", + "cytokines", + "receptor", + "administration", + "interacting", + "due", + "crs", + "targets", + "release", "bind", + "response", + "proteins", + "small", + "subunits", + "long", + "computational", + "cytokine", + "activate", + "localized", + "critical", + "design", + "signaling", + "current", + "mitigate", + "hence", "health", - "therapeutic", - "disease", - "protective", "acute", - "inflammatory", + "prevent", + "therapeutic", + "anakinra", + "commonly", + "systemic", "inflammation", - "proteins", + "demonstrated", + "present", + "range", + "reveal", + "designed", + "organoid", "models", "receptors", - "cytokines", - "de", - "involved", - "response", - "anakinra", - "less", - "small", - "threat", - "picomolar", - "match", "structures", + "de", "suitable", - "effects", - "cardiac", - "activate", - "administration", - "prevent", - "minibinders", - "demonstrated", "injection", - "making", - "cytokine", - "via", - "release", - "damage", "gp130", - "limitations", - "interacting", "closely", - "design", - "model", - "commonly", - "promise", - "present", + "target", + "crystallography", + "known", + "making", + "threat", "routes", "tocilizumab", - "antagonists", - "subunits", - "treatments", - "key", - "systemic", - "known", - "range", - "localized", - "critical", - "storm", - "novo", + "picomolar", + "studies", + "limitations", "human", - "reveal", "affinities", - "due", + "less", "subcutaneous", - "significant", - "protein", - "organoid", - "targets", - "computational", - "global", - "binding", - "crs" + "significant" ], "release_date":"2024-08-28", "publication":"\"De novo design of miniprotein antagonists of cytokine storm inducers\", Nat Commun, 15, 7064-7064", @@ -891617,94 +895280,94 @@ ], "subtitle":"De novo designed il-6 mimetic", "tags":[ - "cytokine", - "de novo design" + "de novo design", + "cytokine" ], "keywords":[ - "hence", - "long", - "studies", - "mitigate", - "signaling", - "crystallography", - "designed", - "receptor", + "treatments", + "disease", + "key", + "show", + "minibinders", + "via", + "cardiac", + "model", + "damage", + "protective", + "protein", + "binding", "syndrome", + "novo", + "storm", + "match", + "inflammatory", + "antagonists", + "promise", "induced", - "current", - "target", - "show", + "global", + "effects", + "involved", + "cytokines", + "receptor", + "administration", + "interacting", + "due", + "crs", + "targets", + "release", "bind", + "response", + "proteins", + "small", + "subunits", + "long", + "computational", + "cytokine", + "activate", + "localized", + "critical", + "design", + "signaling", + "current", + "mitigate", + "hence", "health", - "therapeutic", - "disease", - "protective", "acute", - "inflammatory", + "prevent", + "therapeutic", + "anakinra", + "commonly", + "systemic", "inflammation", - "proteins", + "demonstrated", + "present", + "range", + "reveal", + "designed", + "organoid", "models", "receptors", - "cytokines", - "de", - "involved", - "response", - "anakinra", - "less", - "small", - "threat", - "picomolar", - "match", "structures", + "de", "suitable", - "effects", - "cardiac", - "activate", - "administration", - "prevent", - "minibinders", - "demonstrated", "injection", - "making", - "cytokine", - "via", - "release", - "damage", "gp130", - "limitations", - "interacting", "closely", - "design", - "model", - "commonly", - "promise", - "present", + "target", + "crystallography", + "known", + "making", + "threat", "routes", "tocilizumab", - "antagonists", - "subunits", - "treatments", - "key", - "systemic", - "known", - "range", - "localized", - "critical", - "storm", - "novo", + "picomolar", + "studies", + "limitations", "human", - "reveal", "affinities", - "due", + "less", "subcutaneous", - "significant", - "protein", - "organoid", - "targets", - "computational", - "global", - "binding", - "crs" + "significant" ], "release_date":"2024-08-28", "publication":"\"De novo design of miniprotein antagonists of cytokine storm inducers\", Nat Commun, 15, 7064-7064", @@ -891856,9 +895519,9 @@ ], "subtitle":"Crystal structure of designed cortisol-binding protein hcy129_mpnn5", "tags":[ - "cortisol binding", "de novo protein", - "ntf2" + "ntf2", + "cortisol binding" ], "keywords":[ "description", @@ -892000,137 +895663,137 @@ ], "subtitle":"Cryoem structure of allosterically switchable de novo protein sr312, in open state with effector peptide", "tags":[ - "sr312", - "effector peptide", + "de novo", "allosterically switchable de novo protein", "de novo protein", - "de novo" + "effector peptide", + "sr312" ], "keywords":[ - "classic", - "many", + "optimized", + "whose", + "distance", + "resemble", + "13", + "regulated", + "presence", + "disassembly", "results", + "dihedral", + "delivery", + "characteristic", + "model", + "insight", + "protein", + "mass", + "substructures", + "electron", + "binding", + "changes", + "across", + "cellular", + "microscopy", + "novo", + "nanomachines", + "emulating", + "systems", + "variety", + "global", + "10", + "alternative", + "conformational", + "mechanisms", + "however", + "switchable", + "interest", + "signalling", + "triggers", + "eject", + "allosterically", + "inspired", + "residues", + "functions", + "cyclic", + "communication", + "control", + "allostery", + "approach", + "sites", + "proteins", "part", - "coupling", - "challenge", "modules", + "response", + "coupling", + "roadmap", + "subunits", + "distant", + "pathways", + "wherein", "including", "peptide", - "regulated", - "designed", - "photometry", - "provide", - "allosterically", "11", - "pathways", - "hinge", - "find", - "switchable", - "synthetic", - "chromatography", - "designing", - "however", - "alternative", - "cyclic", + "investigate", + "undergo", "direct", - "interfaces", - "modulation", - "without", - "generating", - "proteins", - "allostery", - "models", - "cell", - "de", - "response", - "rings", - "disassembly", - "presence", + "12", + "designing", + "design", + "subtle", "used", - "comparable", - "arise", - "whose", - "feedback", - "14", - "natural", - "dihedral", - "function", - "cellular", - "systems", - "effectors", - "investigate", - "plays", - "control", - "considerable", "functional", - "assemblies", - "generate", - "changes", - "gain", - "10", - "interest", - "circuitry", - "functions", - "closely", + "natural", + "effector", + "absence", + "arise", + "oligomeric", + "photometry", "triggerable", + "cell", + "14", + "wide", + "chromatography", "cages", - "12", - "design", - "model", - "distance", - "eject", - "distant", - "states", - "across", - "underlying", - "subunits", - "indicate", + "allosteric", "formation", - "resemble", - "communication", + "underlying", + "states", + "hinge", + "effectors", + "generating", + "classic", "incorporate", - "characteristic", - "13", - "sites", - "emulating", - "delivery", + "assemblies", "distributed", - "undergo", - "subtle", - "optimized", - "conformational", - "roadmap", - "approach", - "nanomachines", - "novo", - "wide", - "insight", - "cooperativity", - "electron", - "residues", "reveal", - "effector", - "absence", - "energetics", + "cooperativity", + "designed", "central", - "wherein", - "significant", - "protein", - "microscopy", - "mechanisms", - "signalling", - "variety", - "substructures", - "haemoglobin", - "triggers", + "models", + "many", + "interfaces", + "indicate", + "feedback", + "de", + "comparable", + "without", + "synthetic", + "provide", + "modulation", + "closely", + "circuitry", + "plays", + "function", "metabolism", - "mass", - "oligomeric", - "inspired", - "global", - "binding", + "energetics", + "find", + "gain", + "considerable", + "rings", + "haemoglobin", "create", - "allosteric" + "challenge", + "generate", + "significant" ], "release_date":"2024-08-14", "publication":"\"De novo design of allosterically switchable protein assemblies\", Nature, 632, 911-920", @@ -892167,11 +895830,11 @@ }, { "sim":84.0, - "partner":"8v3b" + "partner":"8v2d" }, { "sim":84.0, - "partner":"8v2d" + "partner":"8v3b" }, { "sim":70.0, @@ -892299,136 +895962,136 @@ ], "subtitle":"Cryoem structure of allosterically switchable de novo protein sr322, in closed state without effector peptide, off target multimeric state", "tags":[ - "closed state", "sr322", "de novo protein", - "allosterically switchable protein" + "allosterically switchable protein", + "closed state" ], "keywords":[ - "classic", - "many", + "optimized", + "whose", + "distance", + "resemble", + "13", + "regulated", + "presence", + "disassembly", "results", + "dihedral", + "delivery", + "characteristic", + "model", + "insight", + "protein", + "mass", + "substructures", + "electron", + "binding", + "changes", + "across", + "cellular", + "microscopy", + "novo", + "nanomachines", + "emulating", + "systems", + "variety", + "global", + "10", + "alternative", + "conformational", + "mechanisms", + "however", + "switchable", + "interest", + "signalling", + "triggers", + "eject", + "allosterically", + "inspired", + "residues", + "functions", + "cyclic", + "communication", + "control", + "allostery", + "approach", + "sites", + "proteins", "part", - "coupling", - "challenge", "modules", + "response", + "coupling", + "roadmap", + "subunits", + "distant", + "pathways", + "wherein", "including", "peptide", - "regulated", - "designed", - "photometry", - "provide", - "allosterically", "11", - "pathways", - "hinge", - "find", - "switchable", - "synthetic", - "chromatography", + "investigate", + "undergo", + "direct", + "12", "designing", - "however", - "alternative", - "cyclic", - "direct", - "interfaces", - "modulation", - "without", - "generating", - "proteins", - "allostery", - "models", - "cell", - "de", - "response", - "rings", - "disassembly", - "presence", + "design", + "subtle", "used", - "comparable", - "arise", - "whose", - "feedback", - "14", - "natural", - "dihedral", - "function", - "cellular", - "systems", - "effectors", - "investigate", - "plays", - "control", - "considerable", "functional", - "assemblies", - "generate", - "changes", - "gain", - "10", - "interest", - "circuitry", - "functions", - "closely", + "natural", + "effector", + "absence", + "arise", + "oligomeric", + "photometry", "triggerable", + "cell", + "14", + "wide", + "chromatography", "cages", - "12", - "design", - "model", - "distance", - "eject", - "distant", - "states", - "across", - "underlying", - "subunits", - "indicate", + "allosteric", "formation", - "resemble", - "communication", + "underlying", + "states", + "hinge", + "effectors", + "generating", + "classic", "incorporate", - "characteristic", - "13", - "sites", - "emulating", - "delivery", + "assemblies", "distributed", - "undergo", - "subtle", - "optimized", - "conformational", - "roadmap", - "approach", - "nanomachines", - "novo", - "wide", - "insight", - "cooperativity", - "electron", - "residues", "reveal", - "effector", - "absence", - "energetics", + "cooperativity", + "designed", "central", - "wherein", - "significant", - "protein", - "microscopy", - "mechanisms", - "signalling", - "variety", - "substructures", - "haemoglobin", - "triggers", + "models", + "many", + "interfaces", + "indicate", + "feedback", + "de", + "comparable", + "without", + "synthetic", + "provide", + "modulation", + "closely", + "circuitry", + "plays", + "function", "metabolism", - "mass", - "oligomeric", - "inspired", - "global", - "binding", + "energetics", + "find", + "gain", + "considerable", + "rings", + "haemoglobin", "create", - "allosteric" + "challenge", + "generate", + "significant" ], "release_date":"2024-08-14", "publication":"\"De novo design of allosterically switchable protein assemblies\", Nature, 632, 911-920", @@ -892545,89 +896208,89 @@ "subtitle":"Solution structure of a 12-mer peptide bearing a bicyclic asx motif mimic (bamm) as a synthetic n-cap", "tags":[ "peptide binding protein", - "synthetic n-cap", - "helix" + "helix", + "synthetic n-cap" ], "keywords":[ - "synthetically", - "many", - "joining", - "biased", - "intramolecular", - "uses", - "broad", - "potentially", - "towards", - "ii", + "hydrophobic", + "structural", + "exclusively", "show", - "interactions", - "synthetic", - "validate", - "structure", - "aspartic", - "database", - "community", - "novel", - "conformations", - "develop", - "perturb", + "trends", + "side", + "comprise", + "via", + "canonical", "ppis", - "testing", - "unique", - "inducing", + "bicyclic", + "perturb", + "protein", + "study", + "probes", "linear", - "disruption", - "interface", + "helical", + "following", + "comprising", "motif", - "nature", - "exclusively", - "searchable", - "natural", - "capping", "motifs", - "heavily", - "powerful", - "following", - "via", - "bamms", - "bicyclic", - "triangles", - "acids", - "fragments", - "useful", - "iii", - "biomimetic", - "canonical", - "provides", - "observed", - "asx", - "helical", - "using", - "hydrophobic", + "potentially", + "two", "secondary", - "effect", - "stapling", - "stabilized", - "comprise", - "structural", - "mimics", + "disruption", "chains", - "accessible", + "using", + "bamms", + "stapling", + "creation", "mimicry", - "study", - "peptides", - "residues", - "two", + "biased", + "effect", + "accessible", "comprises", + "residues", + "helix", + "useful", + "develop", + "broad", + "joining", + "iii", + "intramolecular", + "interface", + "inducing", "studying", - "creation", - "protein", + "heavily", + "aspartic", + "provides", + "natural", + "testing", "section", - "helix", - "trends", - "comprising", - "side", - "probes" + "asx", + "validate", + "uses", + "peptides", + "triangles", + "unique", + "synthetically", + "many", + "community", + "observed", + "fragments", + "structure", + "synthetic", + "powerful", + "interactions", + "nature", + "capping", + "biomimetic", + "mimics", + "towards", + "acids", + "conformations", + "database", + "searchable", + "stabilized", + "novel", + "ii" ], "release_date":"2024-06-05", "publication":"\"Bioinformatics leading to conveniently accessible, helix enforcing, bicyclic ASX motif mimics (BAMMs)\", Nat Commun, 15, 4217-4217", @@ -892741,24 +896404,36 @@ }, { "forename":"C.B.", - "surname":"Billesboelle" + "surname":"Billesbolle" }, { "forename":"J.", "surname":"Tewari" }, { - "forename":"C.L.", - "surname":"del Torrent" + "forename":"C.", + "surname":"Llinas Del Torrent" }, { "forename":"W.J.C.", "surname":"van der Velden" }, + { + "forename":"I.", + "surname":"Ojiro" + }, + { + "forename":"I.", + "surname":"Takayama" + }, { "forename":"B.", "surname":"Faust" }, + { + "forename":"L.", + "surname":"Li" + }, { "forename":"N.", "surname":"Vaidehi" @@ -892781,132 +896456,132 @@ ], "subtitle":"Consensus olfactory receptor consor51 in complex with mini-gs trimeric protein", "tags":[ - "odorant", - "receptor", - "olfaction", + "gpcr", "signaling protein", - "gpcr" + "olfaction", + "receptor", + "odorant" ], "keywords":[ - "lay", - "or51", - "predictive", - "thus", - "modes", + "molecular", + "individual", + "recognition", + "consor", + "consor51", + "groundwork", + "structural", + "smell", + "tuned", + "carboxylic", + "around", + "or51e2", + "three", "strategy", - "biochemical", - "odorant", - "challenge", - "consors", - "determination", - "member", - "receptor", - "generated", + "model", "physicochemical", - "provide", - "consor", - "olfactory", - "inability", - "ii", - "interactions", - "similarity", - "detects", - "represent", - "structure", - "distinguishes", + "protein", + "biochemical", + "ors", + "modelling", + "electron", + "binding", + "showed", + "microscopy", + "predictive", "power", - "receptors", - "carboxylic", + "major", + "two", + "subfamilies", + "variety", + "related", + "g", + "using", + "uncover", + "receptor", + "engineered", + "odours", + "mechanisms", + "determination", "configurations", + "ligand", + "modes", + "thus", + "comprises", + "enabled", + "specific", "family", - "main", - "superfamily", - "tractability", - "olfaction", - "remains", - "recognition", - "smell", - "crafted", - "3", - "individual", - "400", - "structures", + "odorant", "derived", - "showed", - "three", - "respond", - "native", - "revealed", + "member", + "2", "consensus", - "properties", - "homology", - "molecular", - "class", + "activation", "four", - "template", - "consor51", "1", - "acids", - "modelling", - "specific", - "g", - "classes", - "odorants", "design", - "sense", - "model", "vertebrate", - "using", - "perceive", - "high", - "sequence", - "around", - "structural", - "groundwork", + "17", "diverse", - "poorly", - "ligand", - "fundamental", - "visualize", - "wide", - "human", + "classes", + "perceive", + "represent", + "properties", + "cryogenic", + "respond", + "consors", "humans", - "ors", - "enable", - "electron", - "engineered", - "odours", + "template", + "wide", + "superfamily", "understood", - "two", - "comprises", - "repertoire", + "olfaction", + "sequence", "system", - "subfamilies", - "tuned", - "uncover", - "or51e2", - "protein", - "microscopy", - "2", - "animals", - "mechanisms", - "variety", - "17", + "repertoire", + "detects", + "whereas", + "ii", + "tractability", + "or51", + "visualize", + "fundamental", + "crafted", + "revealed", + "poorly", + "receptors", + "main", + "structures", + "400", + "3", + "remains", + "sense", + "distinguishes", + "structure", + "provide", + "olfactory", + "odorants", + "interactions", "understanding", + "class", + "enable", + "high", + "native", "distinct", - "enabled", - "major", - "activation", - "binding", - "cryogenic", - "related", - "whereas" + "generated", + "acids", + "lay", + "inability", + "human", + "challenge", + "similarity", + "animals", + "homology" ], "release_date":"2024-10-30", - "publication":"\"Engineered odorant receptors illuminate the basis of odour discrimination\", Nature", + "publication":"\"Engineered odorant receptors illuminate the basis of odour discrimination\", Nature, 635, 499-508", "publication_ref":{ "DOI":"10.1038\/s41586-024-08126-0", - "PubMed":"", + "PubMed":"39478229", "CSD":"0006", "ISSN":"1476-4687", "ASTM":"NATUAS" @@ -892955,11 +896630,11 @@ }, { "sim":373.0, - "partner":"8w77" + "partner":"8j46" }, { "sim":373.0, - "partner":"8j46" + "partner":"8w77" }, { "sim":58.0, @@ -893072,24 +896747,36 @@ }, { "forename":"C.B.", - "surname":"Billesboelle" + "surname":"Billesbolle" }, { "forename":"J.", "surname":"Tewari" }, { - "forename":"C.L.", - "surname":"del Torrent" + "forename":"C.", + "surname":"Llinas Del Torrent" }, { "forename":"W.J.C.", "surname":"van der Velden" }, + { + "forename":"I.", + "surname":"Ojiro" + }, + { + "forename":"I.", + "surname":"Takayama" + }, { "forename":"B.", "surname":"Faust" }, + { + "forename":"L.", + "surname":"Li" + }, { "forename":"N.", "surname":"Vaidehi" @@ -893112,132 +896799,132 @@ ], "subtitle":"Consensus olfactory receptor consor1 bound to l-menthol and in complex with mini-gs trimeric protein", "tags":[ - "odorant", - "receptor", - "olfaction", + "gpcr", "signaling protein", - "gpcr" + "olfaction", + "receptor", + "odorant" ], "keywords":[ - "lay", - "or51", - "predictive", - "thus", - "modes", + "molecular", + "individual", + "recognition", + "consor", + "consor51", + "groundwork", + "structural", + "smell", + "tuned", + "carboxylic", + "around", + "or51e2", + "three", "strategy", - "biochemical", - "odorant", - "challenge", - "consors", - "determination", - "member", - "receptor", - "generated", + "model", "physicochemical", - "provide", - "consor", - "olfactory", - "inability", - "ii", - "interactions", - "similarity", - "detects", - "represent", - "structure", - "distinguishes", + "protein", + "biochemical", + "ors", + "modelling", + "electron", + "binding", + "showed", + "microscopy", + "predictive", "power", - "receptors", - "carboxylic", + "major", + "two", + "subfamilies", + "variety", + "related", + "g", + "using", + "uncover", + "receptor", + "engineered", + "odours", + "mechanisms", + "determination", "configurations", + "ligand", + "modes", + "thus", + "comprises", + "enabled", + "specific", "family", - "main", - "superfamily", - "tractability", - "olfaction", - "remains", - "recognition", - "smell", - "crafted", - "3", - "individual", - "400", - "structures", + "odorant", "derived", - "showed", - "three", - "respond", - "native", - "revealed", + "member", + "2", "consensus", - "properties", - "homology", - "molecular", - "class", + "activation", "four", - "template", - "consor51", "1", - "acids", - "modelling", - "specific", - "g", - "classes", - "odorants", "design", - "sense", - "model", "vertebrate", - "using", - "perceive", - "high", - "sequence", - "around", - "structural", - "groundwork", + "17", "diverse", - "poorly", - "ligand", - "fundamental", - "visualize", - "wide", - "human", + "classes", + "perceive", + "represent", + "properties", + "cryogenic", + "respond", + "consors", "humans", - "ors", - "enable", - "electron", - "engineered", - "odours", + "template", + "wide", + "superfamily", "understood", - "two", - "comprises", - "repertoire", + "olfaction", + "sequence", "system", - "subfamilies", - "tuned", - "uncover", - "or51e2", - "protein", - "microscopy", - "2", - "animals", - "mechanisms", - "variety", - "17", + "repertoire", + "detects", + "whereas", + "ii", + "tractability", + "or51", + "visualize", + "fundamental", + "crafted", + "revealed", + "poorly", + "receptors", + "main", + "structures", + "400", + "3", + "remains", + "sense", + "distinguishes", + "structure", + "provide", + "olfactory", + "odorants", + "interactions", "understanding", + "class", + "enable", + "high", + "native", "distinct", - "enabled", - "major", - "activation", - "binding", - "cryogenic", - "related", - "whereas" + "generated", + "acids", + "lay", + "inability", + "human", + "challenge", + "similarity", + "animals", + "homology" ], "release_date":"2024-10-30", - "publication":"\"Engineered odorant receptors illuminate the basis of odour discrimination\", Nature", + "publication":"\"Engineered odorant receptors illuminate the basis of odour discrimination\", Nature, 635, 499-508", "publication_ref":{ "DOI":"10.1038\/s41586-024-08126-0", - "PubMed":"", + "PubMed":"39478229", "CSD":"0006", "ISSN":"1476-4687", "ASTM":"NATUAS" @@ -893286,11 +896973,11 @@ }, { "sim":156.0, - "partner":"8w77" + "partner":"8j46" }, { "sim":156.0, - "partner":"8j46" + "partner":"8w77" }, { "sim":65.0, @@ -893298,35 +896985,35 @@ }, { "sim":64.0, - "partner":"7f1o" + "partner":"7f1z" }, { "sim":64.0, - "partner":"7x2c" + "partner":"7x2d" }, { "sim":64.0, - "partner":"7f0t" + "partner":"7x2f" }, { "sim":64.0, - "partner":"7x2d" + "partner":"7f23" }, { "sim":64.0, - "partner":"7f1z" + "partner":"7f24" }, { "sim":64.0, - "partner":"7x2f" + "partner":"7f1o" }, { "sim":64.0, - "partner":"7f23" + "partner":"7f0t" }, { "sim":64.0, - "partner":"7f24" + "partner":"7x2c" }, { "sim":63.0, @@ -893336,14 +897023,6 @@ "sim":63.0, "partner":"7bz2" }, - { - "sim":62.0, - "partner":"8wc6" - }, - { - "sim":62.0, - "partner":"8wc7" - }, { "sim":62.0, "partner":"8wc9" @@ -893370,7 +897049,11 @@ }, { "sim":62.0, - "partner":"8wc8" + "partner":"8wc6" + }, + { + "sim":62.0, + "partner":"8wc7" }, { "sim":62.0, @@ -893394,7 +897077,7 @@ }, { "sim":62.0, - "partner":"7trk" + "partner":"8wc8" }, { "sim":62.0, @@ -893412,6 +897095,10 @@ "sim":62.0, "partner":"7trs" }, + { + "sim":62.0, + "partner":"7trk" + }, { "sim":62.0, "partner":"7dhr" @@ -893430,27 +897117,27 @@ }, { "sim":62.0, - "partner":"8jln" + "partner":"8jlp" }, { "sim":62.0, - "partner":"8jso" + "partner":"8jlq" }, { "sim":62.0, - "partner":"8jlo" + "partner":"8jlr" }, { "sim":62.0, - "partner":"8jlp" + "partner":"8jln" }, { "sim":62.0, - "partner":"8jlq" + "partner":"8jso" }, { "sim":62.0, - "partner":"8jlr" + "partner":"8jlo" }, { "sim":62.0, @@ -893458,15 +897145,15 @@ }, { "sim":62.0, - "partner":"8zsj" + "partner":"8zss" }, { "sim":62.0, - "partner":"8zsp" + "partner":"8zsj" }, { "sim":62.0, - "partner":"8zss" + "partner":"8zsp" }, { "sim":61.0, @@ -893498,319 +897185,319 @@ }, { "sim":60.0, - "partner":"8ge4" + "partner":"8ge6" }, { "sim":60.0, - "partner":"8gec" + "partner":"8gee" }, { "sim":60.0, - "partner":"8unl" + "partner":"8ggk" }, { "sim":60.0, - "partner":"8unt" + "partner":"8unr" }, { "sim":60.0, - "partner":"8gg0" + "partner":"8unz" }, { "sim":60.0, - "partner":"8gg8" + "partner":"8gg2" }, { "sim":60.0, - "partner":"8ge5" + "partner":"8gga" }, { "sim":60.0, - "partner":"8ged" + "partner":"8ggl" }, { "sim":60.0, - "partner":"8unm" + "partner":"8ggm" }, { "sim":60.0, - "partner":"8unu" + "partner":"8ggn" }, { "sim":60.0, - "partner":"8uo2" + "partner":"8ge7" }, { "sim":60.0, - "partner":"8gg1" + "partner":"8gef" }, { "sim":60.0, - "partner":"8gg9" + "partner":"8ggo" }, { "sim":60.0, - "partner":"8ggi" + "partner":"8uns" }, { "sim":60.0, - "partner":"8ggj" + "partner":"8uo0" }, { "sim":60.0, - "partner":"8ge6" + "partner":"8gdz" }, { "sim":60.0, - "partner":"8gee" + "partner":"8gfv" }, { "sim":60.0, - "partner":"8ggk" + "partner":"8gg3" }, { "sim":60.0, - "partner":"8unn" + "partner":"8ggb" }, { "sim":60.0, - "partner":"8unv" + "partner":"8ggp" }, { "sim":60.0, - "partner":"8uo3" + "partner":"8ggq" }, { "sim":60.0, - "partner":"8gg2" + "partner":"8ggr" }, { "sim":60.0, - "partner":"8gga" + "partner":"8ge8" }, { "sim":60.0, - "partner":"8ggl" + "partner":"8geg" }, { "sim":60.0, - "partner":"8ggm" + "partner":"8ggs" }, { "sim":60.0, - "partner":"8ggn" + "partner":"8unl" }, { "sim":60.0, - "partner":"8ge7" + "partner":"8unt" }, { "sim":60.0, - "partner":"8gef" + "partner":"8gfw" }, { "sim":60.0, - "partner":"8ggo" + "partner":"8gg4" }, { "sim":60.0, - "partner":"8uno" + "partner":"8ggc" }, { "sim":60.0, - "partner":"8unw" + "partner":"8ggt" }, { "sim":60.0, - "partner":"8uo4" + "partner":"8ggu" }, { "sim":60.0, - "partner":"8gdz" + "partner":"8ggv" }, { "sim":60.0, - "partner":"8gfv" + "partner":"8ge1" }, { "sim":60.0, - "partner":"8gg3" + "partner":"8ge9" }, { "sim":60.0, - "partner":"8ggb" + "partner":"8geh" }, { "sim":60.0, - "partner":"8ggp" + "partner":"8ggw" }, { "sim":60.0, - "partner":"8ggq" + "partner":"8unm" }, { "sim":60.0, - "partner":"8ggr" + "partner":"8unu" }, { "sim":60.0, - "partner":"8ge8" + "partner":"8uo2" }, { "sim":60.0, - "partner":"8geg" + "partner":"8gfx" }, { "sim":60.0, - "partner":"8ggs" + "partner":"8gg5" }, { "sim":60.0, - "partner":"8unp" + "partner":"8ggx" }, { "sim":60.0, - "partner":"8unx" + "partner":"8ggy" }, { "sim":60.0, - "partner":"8gfw" + "partner":"8ggz" }, { "sim":60.0, - "partner":"8gg4" + "partner":"8ge2" }, { "sim":60.0, - "partner":"8ggc" + "partner":"8gea" }, { "sim":60.0, - "partner":"8ggt" + "partner":"8gei" }, { "sim":60.0, - "partner":"8ggu" + "partner":"8gh0" }, { "sim":60.0, - "partner":"8ggv" + "partner":"8unn" }, { "sim":60.0, - "partner":"8ge1" + "partner":"8unv" }, { "sim":60.0, - "partner":"8ge9" + "partner":"8uo3" }, { "sim":60.0, - "partner":"8geh" + "partner":"8gfy" }, { "sim":60.0, - "partner":"8ggw" + "partner":"8gg6" }, { "sim":60.0, - "partner":"8unq" + "partner":"8gh1" }, { "sim":60.0, - "partner":"8uny" + "partner":"8gge" }, { "sim":60.0, - "partner":"8gfx" + "partner":"8ge3" }, { "sim":60.0, - "partner":"8gg5" + "partner":"8geb" }, { "sim":60.0, - "partner":"8ggx" + "partner":"8gej" }, { "sim":60.0, - "partner":"8ggy" + "partner":"8uno" }, { "sim":60.0, - "partner":"8ggz" + "partner":"8unw" }, { "sim":60.0, - "partner":"8ge2" + "partner":"8uo4" }, { "sim":60.0, - "partner":"8gea" + "partner":"8gfz" }, { "sim":60.0, - "partner":"8gei" + "partner":"8gg7" }, { "sim":60.0, - "partner":"8gh0" + "partner":"8ggf" }, { "sim":60.0, - "partner":"8unr" + "partner":"8ge4" }, { "sim":60.0, - "partner":"8unz" + "partner":"8gec" }, { "sim":60.0, - "partner":"8gfy" + "partner":"8unp" }, { "sim":60.0, - "partner":"8gg6" + "partner":"8unx" }, { "sim":60.0, - "partner":"8gh1" + "partner":"8gg0" }, { "sim":60.0, - "partner":"8gge" + "partner":"8gg8" }, { "sim":60.0, - "partner":"8ge3" + "partner":"8ge5" }, { "sim":60.0, - "partner":"8geb" + "partner":"8ged" }, { "sim":60.0, - "partner":"8gej" + "partner":"8unq" }, { "sim":60.0, - "partner":"8uns" + "partner":"8uny" }, { "sim":60.0, - "partner":"8uo0" + "partner":"8gg1" }, { "sim":60.0, - "partner":"8gfz" + "partner":"8gg9" }, { "sim":60.0, - "partner":"8gg7" + "partner":"8ggi" }, { "sim":60.0, - "partner":"8ggf" + "partner":"8ggj" }, { "sim":60.0, @@ -893822,11 +897509,11 @@ }, { "sim":59.0, - "partner":"9cbl" + "partner":"9cbm" }, { "sim":59.0, - "partner":"9cbm" + "partner":"9cbl" }, { "sim":57.0, @@ -893842,7 +897529,7 @@ }, { "sim":57.0, - "partner":"6n48" + "partner":"7xk9" }, { "sim":57.0, @@ -893850,15 +897537,15 @@ }, { "sim":57.0, - "partner":"7xk9" + "partner":"7xka" }, { "sim":57.0, - "partner":"7xka" + "partner":"4lde" }, { "sim":57.0, - "partner":"4lde" + "partner":"6n48" }, { "sim":57.0, @@ -893880,14 +897567,6 @@ "sim":56.0, "partner":"7xjl" }, - { - "sim":56.0, - "partner":"8iwm" - }, - { - "sim":56.0, - "partner":"8iw9" - }, { "sim":56.0, "partner":"8iw1" @@ -893910,15 +897589,15 @@ }, { "sim":56.0, - "partner":"6v9s" + "partner":"8iwm" }, { - "sim":55.0, - "partner":"6tp4" + "sim":56.0, + "partner":"8iw9" }, { - "sim":55.0, - "partner":"6kr8" + "sim":56.0, + "partner":"6v9s" }, { "sim":55.0, @@ -893942,7 +897621,11 @@ }, { "sim":55.0, - "partner":"7t94" + "partner":"6tp4" + }, + { + "sim":55.0, + "partner":"6kr8" }, { "sim":55.0, @@ -893962,11 +897645,11 @@ }, { "sim":55.0, - "partner":"8pm2" + "partner":"7t94" }, { "sim":55.0, - "partner":"6tp6" + "partner":"8pm2" }, { "sim":55.0, @@ -893986,19 +897669,19 @@ }, { "sim":55.0, - "partner":"6wgt" + "partner":"6tp6" }, { "sim":55.0, - "partner":"6wh4" + "partner":"6wgt" }, { "sim":55.0, - "partner":"5jqh" + "partner":"6wh4" }, { "sim":55.0, - "partner":"6ps6" + "partner":"5jqh" }, { "sim":55.0, @@ -894030,15 +897713,19 @@ }, { "sim":55.0, - "partner":"8wkz" + "partner":"6ps6" }, { "sim":55.0, - "partner":"6w25" + "partner":"8wky" }, { "sim":55.0, - "partner":"8wky" + "partner":"8wkz" + }, + { + "sim":55.0, + "partner":"6w25" }, { "sim":55.0, @@ -894058,11 +897745,11 @@ }, { "sim":54.0, - "partner":"7rmg" + "partner":"8u26" }, { "sim":54.0, - "partner":"8u26" + "partner":"7rmg" }, { "sim":54.0, @@ -894090,11 +897777,11 @@ }, { "sim":53.0, - "partner":"8zps" + "partner":"8zpt" }, { "sim":53.0, - "partner":"8zpt" + "partner":"8zps" }, { "sim":53.0, @@ -894152,17 +897839,13 @@ "sim":51.0, "partner":"8v6u" }, - { - "sim":51.0, - "partner":"7ran" - }, { "sim":51.0, "partner":"8uwl" }, { "sim":51.0, - "partner":"7piv" + "partner":"7ran" }, { "sim":51.0, @@ -894170,12 +897853,16 @@ }, { "sim":51.0, - "partner":"4mqt" + "partner":"7piv" }, { "sim":51.0, "partner":"4mqs" }, + { + "sim":51.0, + "partner":"4mqt" + }, { "sim":51.0, "partner":"8jt8" @@ -894270,15 +897957,15 @@ }, { "sim":51.0, - "partner":"8inr" + "partner":"5t04" }, { "sim":51.0, - "partner":"5t04" + "partner":"8iod" }, { "sim":51.0, - "partner":"8iod" + "partner":"8inr" }, { "sim":51.0, @@ -894286,11 +897973,11 @@ }, { "sim":51.0, - "partner":"7f8u" + "partner":"7f8y" }, { "sim":51.0, - "partner":"7f8y" + "partner":"7f8u" }, { "sim":51.0, @@ -894302,15 +897989,15 @@ }, { "sim":50.0, - "partner":"7v6a" + "partner":"7v68" }, { "sim":50.0, - "partner":"7v68" + "partner":"7v69" }, { "sim":50.0, - "partner":"7v69" + "partner":"7v6a" }, { "sim":50.0, @@ -894330,11 +898017,11 @@ }, { "sim":50.0, - "partner":"7l1u" + "partner":"7l1v" }, { "sim":50.0, - "partner":"7l1v" + "partner":"7l1u" }, { "sim":50.0, @@ -894346,11 +898033,11 @@ }, { "sim":50.0, - "partner":"7xou" + "partner":"7ezh" }, { "sim":50.0, - "partner":"7ezh" + "partner":"7xou" }, { "sim":50.0, @@ -894370,15 +898057,15 @@ }, { "sim":50.0, - "partner":"3ayn" + "partner":"2z73" }, { "sim":50.0, - "partner":"2z73" + "partner":"3aym" }, { "sim":50.0, - "partner":"3aym" + "partner":"3ayn" }, { "sim":50.0, @@ -894471,24 +898158,36 @@ }, { "forename":"C.B.", - "surname":"Billesboelle" + "surname":"Billesbolle" }, { "forename":"J.", "surname":"Tewari" }, { - "forename":"C.L.", - "surname":"del Torrent" + "forename":"C.", + "surname":"Llinas Del Torrent" }, { "forename":"W.J.C.", "surname":"van der Velden" }, + { + "forename":"I.", + "surname":"Ojiro" + }, + { + "forename":"I.", + "surname":"Takayama" + }, { "forename":"B.", "surname":"Faust" }, + { + "forename":"L.", + "surname":"Li" + }, { "forename":"N.", "surname":"Vaidehi" @@ -894511,132 +898210,132 @@ ], "subtitle":"Consensus olfactory receptor consor2 bound to s-carvone and in complex with mini-gs trimeric protein", "tags":[ - "odorant", - "receptor", - "olfaction", + "gpcr", "signaling protein", - "gpcr" + "olfaction", + "receptor", + "odorant" ], "keywords":[ - "lay", - "or51", - "predictive", - "thus", - "modes", + "molecular", + "individual", + "recognition", + "consor", + "consor51", + "groundwork", + "structural", + "smell", + "tuned", + "carboxylic", + "around", + "or51e2", + "three", "strategy", - "biochemical", - "odorant", - "challenge", - "consors", - "determination", - "member", - "receptor", - "generated", + "model", "physicochemical", - "provide", - "consor", - "olfactory", - "inability", - "ii", - "interactions", - "similarity", - "detects", - "represent", - "structure", - "distinguishes", + "protein", + "biochemical", + "ors", + "modelling", + "electron", + "binding", + "showed", + "microscopy", + "predictive", "power", - "receptors", - "carboxylic", + "major", + "two", + "subfamilies", + "variety", + "related", + "g", + "using", + "uncover", + "receptor", + "engineered", + "odours", + "mechanisms", + "determination", "configurations", + "ligand", + "modes", + "thus", + "comprises", + "enabled", + "specific", "family", - "main", - "superfamily", - "tractability", - "olfaction", - "remains", - "recognition", - "smell", - "crafted", - "3", - "individual", - "400", - "structures", + "odorant", "derived", - "showed", - "three", - "respond", - "native", - "revealed", + "member", + "2", "consensus", - "properties", - "homology", - "molecular", - "class", + "activation", "four", - "template", - "consor51", "1", - "acids", - "modelling", - "specific", - "g", - "classes", - "odorants", "design", - "sense", - "model", "vertebrate", - "using", - "perceive", - "high", - "sequence", - "around", - "structural", - "groundwork", + "17", "diverse", - "poorly", - "ligand", - "fundamental", - "visualize", - "wide", - "human", + "classes", + "perceive", + "represent", + "properties", + "cryogenic", + "respond", + "consors", "humans", - "ors", - "enable", - "electron", - "engineered", - "odours", + "template", + "wide", + "superfamily", "understood", - "two", - "comprises", - "repertoire", + "olfaction", + "sequence", "system", - "subfamilies", - "tuned", - "uncover", - "or51e2", - "protein", - "microscopy", - "2", - "animals", - "mechanisms", - "variety", - "17", + "repertoire", + "detects", + "whereas", + "ii", + "tractability", + "or51", + "visualize", + "fundamental", + "crafted", + "revealed", + "poorly", + "receptors", + "main", + "structures", + "400", + "3", + "remains", + "sense", + "distinguishes", + "structure", + "provide", + "olfactory", + "odorants", + "interactions", "understanding", + "class", + "enable", + "high", + "native", "distinct", - "enabled", - "major", - "activation", - "binding", - "cryogenic", - "related", - "whereas" + "generated", + "acids", + "lay", + "inability", + "human", + "challenge", + "similarity", + "animals", + "homology" ], "release_date":"2024-10-30", - "publication":"\"Engineered odorant receptors illuminate the basis of odour discrimination\", Nature", + "publication":"\"Engineered odorant receptors illuminate the basis of odour discrimination\", Nature, 635, 499-508", "publication_ref":{ "DOI":"10.1038\/s41586-024-08126-0", - "PubMed":"", + "PubMed":"39478229", "CSD":"0006", "ISSN":"1476-4687", "ASTM":"NATUAS" @@ -894685,11 +898384,11 @@ }, { "sim":139.0, - "partner":"8w77" + "partner":"8j46" }, { "sim":139.0, - "partner":"8j46" + "partner":"8w77" }, { "sim":76.0, @@ -894697,35 +898396,35 @@ }, { "sim":67.0, - "partner":"7f1o" + "partner":"7f1z" }, { "sim":67.0, - "partner":"7x2c" + "partner":"7x2d" }, { "sim":67.0, - "partner":"7f0t" + "partner":"7x2f" }, { "sim":67.0, - "partner":"7x2d" + "partner":"7f23" }, { "sim":67.0, - "partner":"7f1z" + "partner":"7f24" }, { "sim":67.0, - "partner":"7x2f" + "partner":"7f1o" }, { "sim":67.0, - "partner":"7f23" + "partner":"7f0t" }, { "sim":67.0, - "partner":"7f24" + "partner":"7x2c" }, { "sim":65.0, @@ -894751,10 +898450,6 @@ "sim":57.0, "partner":"8smv" }, - { - "sim":56.0, - "partner":"8wc8" - }, { "sim":56.0, "partner":"8w87" @@ -894777,39 +898472,43 @@ }, { "sim":56.0, - "partner":"8jln" + "partner":"8wc8" }, { "sim":56.0, - "partner":"8jso" + "partner":"8jlp" }, { "sim":56.0, - "partner":"8jlo" + "partner":"8jlq" }, { "sim":56.0, - "partner":"8jlp" + "partner":"8jlr" }, { "sim":56.0, - "partner":"8jlq" + "partner":"8jln" }, { "sim":56.0, - "partner":"8jlr" + "partner":"8jso" }, { "sim":56.0, - "partner":"8zsj" + "partner":"8jlo" }, { "sim":56.0, - "partner":"8zsp" + "partner":"8zss" }, { "sim":56.0, - "partner":"8zss" + "partner":"8zsj" + }, + { + "sim":56.0, + "partner":"8zsp" }, { "sim":56.0, @@ -894823,14 +898522,6 @@ "sim":55.0, "partner":"7ys6" }, - { - "sim":54.0, - "partner":"8wc6" - }, - { - "sim":54.0, - "partner":"8wc7" - }, { "sim":54.0, "partner":"8wc9" @@ -894857,11 +898548,11 @@ }, { "sim":54.0, - "partner":"8iwm" + "partner":"8wc6" }, { "sim":54.0, - "partner":"8iw9" + "partner":"8wc7" }, { "sim":54.0, @@ -894885,7 +898576,11 @@ }, { "sim":54.0, - "partner":"7trk" + "partner":"8iwm" + }, + { + "sim":54.0, + "partner":"8iw9" }, { "sim":54.0, @@ -894903,6 +898598,10 @@ "sim":54.0, "partner":"7trs" }, + { + "sim":54.0, + "partner":"7trk" + }, { "sim":54.0, "partner":"8jlj" @@ -894935,10 +898634,6 @@ "sim":53.0, "partner":"7w40" }, - { - "sim":52.0, - "partner":"7t94" - }, { "sim":52.0, "partner":"6oik" @@ -894955,6 +898650,10 @@ "sim":52.0, "partner":"7t90" }, + { + "sim":52.0, + "partner":"7t94" + }, { "sim":52.0, "partner":"7dhr" @@ -894993,335 +898692,335 @@ }, { "sim":52.0, - "partner":"8ge4" + "partner":"8ge6" }, { "sim":52.0, - "partner":"8gec" + "partner":"8gee" }, { "sim":52.0, - "partner":"8unl" + "partner":"8ggk" }, { "sim":52.0, - "partner":"8unt" + "partner":"8unr" }, { "sim":52.0, - "partner":"8gg0" + "partner":"8unz" }, { "sim":52.0, - "partner":"8gg8" + "partner":"8gg2" }, { "sim":52.0, - "partner":"8ge5" + "partner":"8gga" }, { "sim":52.0, - "partner":"8ged" + "partner":"8ggl" }, { "sim":52.0, - "partner":"8unm" + "partner":"8ggm" }, { "sim":52.0, - "partner":"8unu" + "partner":"8ggn" }, { "sim":52.0, - "partner":"8uo2" + "partner":"8ge7" }, { "sim":52.0, - "partner":"8gg1" + "partner":"8gef" }, { "sim":52.0, - "partner":"8gg9" + "partner":"8ggo" }, { "sim":52.0, - "partner":"8ggi" + "partner":"8uns" }, { "sim":52.0, - "partner":"8ggj" + "partner":"8uo0" }, { "sim":52.0, - "partner":"8ge6" + "partner":"8gdz" }, { "sim":52.0, - "partner":"8gee" + "partner":"8gfv" }, { "sim":52.0, - "partner":"8ggk" + "partner":"8gg3" }, { "sim":52.0, - "partner":"8unn" + "partner":"8ggb" }, { "sim":52.0, - "partner":"8unv" + "partner":"8ggp" }, { "sim":52.0, - "partner":"8uo3" + "partner":"8ggq" }, { "sim":52.0, - "partner":"8gg2" + "partner":"8ggr" }, { "sim":52.0, - "partner":"8gga" + "partner":"8ge8" }, { "sim":52.0, - "partner":"8ggl" + "partner":"8geg" }, { "sim":52.0, - "partner":"8ggm" + "partner":"8ggs" }, { "sim":52.0, - "partner":"8ggn" + "partner":"8unl" }, { "sim":52.0, - "partner":"8ge7" + "partner":"8unt" }, { "sim":52.0, - "partner":"8gef" + "partner":"8gfw" }, { "sim":52.0, - "partner":"8ggo" + "partner":"8gg4" }, { "sim":52.0, - "partner":"8uno" + "partner":"8ggc" }, { "sim":52.0, - "partner":"8unw" + "partner":"8ggt" }, { "sim":52.0, - "partner":"8uo4" + "partner":"8ggu" }, { "sim":52.0, - "partner":"8gdz" + "partner":"8ggv" }, { "sim":52.0, - 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"partner":"8geh" + "partner":"8gfy" }, { "sim":52.0, - "partner":"8ggw" + "partner":"8gg6" }, { "sim":52.0, - "partner":"8unq" + "partner":"8gh1" }, { "sim":52.0, - "partner":"8uny" + "partner":"8gge" }, { "sim":52.0, - "partner":"8gfx" + "partner":"8ge3" }, { "sim":52.0, - "partner":"8gg5" + "partner":"8geb" }, { "sim":52.0, - "partner":"8ggx" + "partner":"8gej" }, { "sim":52.0, - "partner":"8ggy" + "partner":"8uno" }, { "sim":52.0, - "partner":"8ggz" + "partner":"8unw" }, { "sim":52.0, - "partner":"8ge2" + "partner":"8uo4" }, { "sim":52.0, - "partner":"8gea" + "partner":"8gfz" }, { "sim":52.0, - "partner":"8gei" + "partner":"8gg7" }, { "sim":52.0, - "partner":"8gh0" + "partner":"8ggf" }, { "sim":52.0, - "partner":"8unr" + "partner":"8ge4" }, { "sim":52.0, - "partner":"8unz" + "partner":"8gec" }, { "sim":52.0, - "partner":"8gfy" + "partner":"8unp" }, { "sim":52.0, - "partner":"8gg6" + "partner":"8unx" }, { "sim":52.0, - "partner":"8gh1" + "partner":"8gg0" }, { "sim":52.0, - "partner":"8gge" + "partner":"8gg8" }, { "sim":52.0, - "partner":"8ge3" + "partner":"8ge5" }, { "sim":52.0, - "partner":"8geb" + "partner":"8ged" }, { "sim":52.0, - "partner":"8gej" + "partner":"8unq" }, { "sim":52.0, - "partner":"8uns" + "partner":"8uny" }, { "sim":52.0, - "partner":"8uo0" + "partner":"8gg1" }, { "sim":52.0, - "partner":"8gfz" + "partner":"8gg9" }, { "sim":52.0, - "partner":"8gg7" + "partner":"8ggi" }, { "sim":52.0, - "partner":"8ggf" + "partner":"8ggj" }, { "sim":51.0, - "partner":"8p12" + "partner":"8p15" }, { "sim":51.0, - "partner":"8p13" + "partner":"8p12" }, { "sim":51.0, - "partner":"8p15" + "partner":"6qno" }, { "sim":51.0, - "partner":"6qno" + "partner":"8p13" }, { "sim":51.0, @@ -895526,24 +899225,36 @@ }, { "forename":"C.B.", - "surname":"Billesboelle" + "surname":"Billesbolle" }, { "forename":"J.", "surname":"Tewari" }, { - "forename":"C.L.", - "surname":"del Torrent" + "forename":"C.", + "surname":"Llinas Del Torrent" }, { "forename":"W.J.C.", "surname":"van der Velden" }, + { + "forename":"I.", + "surname":"Ojiro" + }, + { + "forename":"I.", + "surname":"Takayama" + }, { "forename":"B.", "surname":"Faust" }, + { + "forename":"L.", + "surname":"Li" + }, { "forename":"N.", "surname":"Vaidehi" @@ -895566,132 +899277,132 @@ ], "subtitle":"Consensus olfactory receptor consor4 bound to 2-methylthiazoline and in complex with mini-gs trimeric protein", "tags":[ - "odorant", - "receptor", - "olfaction", + "gpcr", "signaling protein", - "gpcr" + "olfaction", + "receptor", + "odorant" ], "keywords":[ - "lay", - "or51", - "predictive", - "thus", - "modes", + "molecular", + "individual", + "recognition", + "consor", + "consor51", + "groundwork", + "structural", + "smell", + "tuned", + "carboxylic", + "around", + "or51e2", + "three", "strategy", - "biochemical", - "odorant", - "challenge", - "consors", - "determination", - "member", - "receptor", - "generated", + "model", "physicochemical", - "provide", - "consor", - "olfactory", - "inability", - "ii", - "interactions", - "similarity", - "detects", - "represent", - "structure", - "distinguishes", + "protein", + "biochemical", + "ors", + "modelling", + "electron", + "binding", + "showed", + "microscopy", + "predictive", "power", - "receptors", - "carboxylic", + "major", + "two", + "subfamilies", + "variety", + "related", + "g", + "using", + "uncover", + "receptor", + "engineered", + "odours", + "mechanisms", + "determination", "configurations", + "ligand", + "modes", + "thus", + "comprises", + "enabled", + "specific", "family", - "main", - "superfamily", - "tractability", - "olfaction", - "remains", - "recognition", - "smell", - "crafted", - "3", - "individual", - "400", - "structures", + "odorant", "derived", - "showed", - "three", - "respond", - "native", - "revealed", + "member", + "2", "consensus", - "properties", - "homology", - "molecular", - "class", + "activation", "four", - "template", - "consor51", "1", - "acids", - "modelling", - "specific", - "g", - "classes", - "odorants", "design", - "sense", - "model", "vertebrate", - "using", - "perceive", - "high", - "sequence", - "around", - "structural", - "groundwork", + "17", "diverse", - "poorly", - "ligand", - "fundamental", - "visualize", - "wide", - "human", + "classes", + "perceive", + "represent", + "properties", + "cryogenic", + "respond", + "consors", "humans", - "ors", - "enable", - "electron", - "engineered", - "odours", + "template", + "wide", + "superfamily", "understood", - "two", - "comprises", - "repertoire", + "olfaction", + "sequence", "system", - "subfamilies", - "tuned", - "uncover", - "or51e2", - "protein", - "microscopy", - "2", - "animals", - "mechanisms", - "variety", - "17", + "repertoire", + "detects", + "whereas", + "ii", + "tractability", + "or51", + "visualize", + "fundamental", + "crafted", + "revealed", + "poorly", + "receptors", + "main", + "structures", + "400", + "3", + "remains", + "sense", + "distinguishes", + "structure", + "provide", + "olfactory", + "odorants", + "interactions", "understanding", + "class", + "enable", + "high", + "native", "distinct", - "enabled", - "major", - "activation", - "binding", - "cryogenic", - "related", - "whereas" + "generated", + "acids", + "lay", + "inability", + "human", + "challenge", + "similarity", + "animals", + "homology" ], "release_date":"2024-10-30", - "publication":"\"Engineered odorant receptors illuminate the basis of odour discrimination\", Nature", + "publication":"\"Engineered odorant receptors illuminate the basis of odour discrimination\", Nature, 635, 499-508", "publication_ref":{ "DOI":"10.1038\/s41586-024-08126-0", - "PubMed":"", + "PubMed":"39478229", "CSD":"0006", "ISSN":"1476-4687", "ASTM":"NATUAS" @@ -895738,21 +899449,13 @@ "sim":164.0, "partner":"8f76" }, - { - "sim":146.0, - "partner":"8w77" - }, { "sim":146.0, "partner":"8j46" }, { - "sim":59.0, - "partner":"8wc6" - }, - { - "sim":59.0, - "partner":"8wc7" + "sim":146.0, + "partner":"8w77" }, { "sim":59.0, @@ -895778,6 +899481,14 @@ "sim":59.0, "partner":"8wcc" }, + { + "sim":59.0, + "partner":"8wc6" + }, + { + "sim":59.0, + "partner":"8wc7" + }, { "sim":59.0, "partner":"8jlj" @@ -895794,10 +899505,6 @@ "sim":58.0, "partner":"8hn1" }, - { - "sim":57.0, - "partner":"8wc8" - }, { "sim":57.0, "partner":"8w87" @@ -895818,41 +899525,45 @@ "sim":57.0, "partner":"8w8a" }, + { + "sim":57.0, + "partner":"8wc8" + }, { "sim":57.0, "partner":"7ymj" }, { "sim":57.0, - "partner":"7f1o" + "partner":"7f1z" }, { "sim":57.0, - "partner":"7x2c" + "partner":"7x2d" }, { "sim":57.0, - "partner":"7f0t" + "partner":"7x2f" }, { "sim":57.0, - "partner":"7x2d" + "partner":"7f23" }, { "sim":57.0, - 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{ - "sim":54.0, - "partner":"8wky" - }, { "sim":53.0, "partner":"8pm2" @@ -895940,31 +899651,31 @@ }, { "sim":51.0, - "partner":"8iwm" + "partner":"8iw1" }, { "sim":51.0, - "partner":"8iw9" + "partner":"8itf" }, { "sim":51.0, - "partner":"8iw1" + "partner":"8iw4" }, { "sim":51.0, - "partner":"8itf" + "partner":"8iw7" }, { "sim":51.0, - "partner":"8iw4" + "partner":"8iwe" }, { "sim":51.0, - "partner":"8iw7" + "partner":"8iwm" }, { "sim":51.0, - "partner":"8iwe" + "partner":"8iw9" }, { "sim":51.0, @@ -895980,11 +899691,11 @@ }, { "sim":51.0, - "partner":"8zps" + "partner":"8zpt" }, { "sim":51.0, - "partner":"8zpt" + "partner":"8zps" }, { "sim":51.0, @@ -896008,11 +899719,11 @@ }, { "sim":50.0, - "partner":"7piv" + "partner":"7piu" }, { "sim":50.0, - "partner":"7piu" + "partner":"7piv" }, { "sim":50.0, @@ -896020,319 +899731,319 @@ }, { "sim":50.0, - "partner":"8ge4" + "partner":"8ge6" }, { "sim":50.0, - "partner":"8gec" + "partner":"8gee" }, { "sim":50.0, - "partner":"8unl" + "partner":"8ggk" }, { "sim":50.0, - 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"partner":"8ggs" + "partner":"8gg5" }, { "sim":50.0, - "partner":"8unp" + "partner":"8ggx" }, { "sim":50.0, - "partner":"8unx" + "partner":"8ggy" }, { "sim":50.0, - "partner":"8gfw" + "partner":"8ggz" }, { "sim":50.0, - "partner":"8gg4" + "partner":"8ge2" }, { "sim":50.0, - "partner":"8ggc" + "partner":"8gea" }, { "sim":50.0, - "partner":"8ggt" + "partner":"8gei" }, { "sim":50.0, - "partner":"8ggu" + "partner":"8gh0" }, { "sim":50.0, - "partner":"8ggv" + "partner":"8unn" }, { "sim":50.0, - "partner":"8ge1" + "partner":"8unv" }, { "sim":50.0, - "partner":"8ge9" + "partner":"8uo3" }, { "sim":50.0, - "partner":"8geh" + "partner":"8gfy" }, { "sim":50.0, - "partner":"8ggw" + "partner":"8gg6" }, { "sim":50.0, - "partner":"8unq" + "partner":"8gh1" }, { "sim":50.0, - "partner":"8uny" + "partner":"8gge" }, { "sim":50.0, - "partner":"8gfx" + "partner":"8ge3" }, { "sim":50.0, - "partner":"8gg5" + "partner":"8geb" }, { "sim":50.0, - "partner":"8ggx" + "partner":"8gej" }, { "sim":50.0, - "partner":"8ggy" + "partner":"8uno" }, { "sim":50.0, - "partner":"8ggz" + "partner":"8unw" }, { "sim":50.0, - "partner":"8ge2" + "partner":"8uo4" }, { "sim":50.0, - "partner":"8gea" + "partner":"8gfz" }, { "sim":50.0, - "partner":"8gei" + "partner":"8gg7" }, { "sim":50.0, - "partner":"8gh0" + "partner":"8ggf" }, { "sim":50.0, - "partner":"8unr" + "partner":"8ge4" }, { "sim":50.0, - "partner":"8unz" + "partner":"8gec" }, { "sim":50.0, - "partner":"8gfy" + "partner":"8unp" }, { "sim":50.0, - "partner":"8gg6" + "partner":"8unx" }, { "sim":50.0, - "partner":"8gh1" + "partner":"8gg0" }, { "sim":50.0, - "partner":"8gge" + "partner":"8gg8" }, { "sim":50.0, - "partner":"8ge3" + "partner":"8ge5" }, { "sim":50.0, - "partner":"8geb" + "partner":"8ged" }, { "sim":50.0, - "partner":"8gej" + "partner":"8unq" }, { "sim":50.0, - "partner":"8uns" + "partner":"8uny" }, { "sim":50.0, - "partner":"8uo0" + "partner":"8gg1" }, { "sim":50.0, - "partner":"8gfz" + "partner":"8gg9" }, { "sim":50.0, - "partner":"8gg7" + "partner":"8ggi" }, { "sim":50.0, - "partner":"8ggf" + "partner":"8ggj" } ], "struct_thr_sim_designed":[ @@ -896409,123 +900120,123 @@ ], "subtitle":"Crystal structure of the reconstruction of the ancestral triosephosphate isomerase of the last opisthokont common ancestor obtained by bayesian inference with pgh", "tags":[ - "triose phosphate isomerase", + "isomerase", "ancestral sequence reconstruction", - "isomerase" + "triose phosphate isomerase" ], "keywords":[ - "work", - "tims", - "analysis", - "evolution", - "unfolding", - "lineages", - "evidence", - "oligomers", - "monomeric", - "located", - "part", - "bonds", - "conserved", - "test", - "isomerase", - "physicochemical", "opisthokonts", - "protozoan", - "reconstruction", - "sequences", - "robustness", - "equilibrium", - "structure", - "monomer", - "applied", - "oligomer", - "resembles", - "unstable", - "spectroscopic", + "tot", + "hydrodynamic", + "well", + "opisthokonta", + "presence", + "differences", + "bottom", + "locatims", "locatim", - "structured", - "reversible", - "resembling", - "reached", - "similar", - "infer", - "obligated", - "calorimetric", + "unstable", + "parameters", + "resembles", + "physicochemical", + "study", "indicated", - "although", - "strongly", - "locatims", - "presence", - "used", - "ancestral", - "comparative", - "structures", - "transitions", - "function", + "unfolding", "showed", - "triosephosphate", - "intermediates", + "equilibrium", "extensive", + "test", + "catalytic", + "two", + "infer", + "lineages", + "similar", + "worst", + "reconstructed", "shows", - "coupled", + "conformational", + "isomerase", + "ones", + "intermediates", + "although", + "last", + "case", + "strongly", + "triosephosphate", + "stability", + "part", + "evidence", + "characterization", + "several", + "ancestral", "hydrogen", "inference", - "properties", - "previously", - "stability", - "monomers", - "bottom", + "found", + "reached", + "\u03b4g", + "resembling", + "evolution", "higher", - "common", - "worst", - "methodologies", - "catalytic", - "temperature", - "four", - "unf", "diverged", - "observed", - "several", - "melting", - "characterization", - "confidence", - "rather", - "\u03b4g", - "high", - "sequence", - "parameters", + "robustness", + "four", + "monomer", + "barrel", + "correlation", "increase", + "spectroscopic", + "calorimetric", + "work", + "used", "extant", - "notably", - "ancestor", - "ones", - "tim", - "hydrodynamic", + "different", + "transitions", + "monomers", + "properties", + "bonds", + "also", + "reversible", + "confidence", + "inactive", + "methodologies", + "oligomer", + "unf", "plausible", + "notably", + "sequence", + "applied", + "common", "3d", - "opisthokonta", - "conformational", - "estimated", - "also", - "study", + "analysis", + "coupled", + "sequences", + "comparative", + "conserved", + "rather", + "observed", + "structures", + "reconstruction", + "oligomers", + "previously", + "structured", + "structure", + "monomeric", "fungi", - "barrel", - "tot", - "well", - "last", - "different", - "found", - "two", - "reconstructed", - "inactive", + "scenario", + "temperature", + "biophysical", + "function", + "melting", + "obligated", "energetics", + "located", + "high", + "estimated", + "tim", + "tims", + "ancestor", "animals", - "differences", - "scenario", - "case", - "correlation", - "biophysical" + "protozoan" ], "release_date":"2024-09-04", "publication":"\"Stable monomers in the ancestral sequence reconstruction of the last opisthokont common ancestor of dimeric triosephosphate isomerase\", Protein Sci., 33, e5134-e5134", @@ -896566,19 +900277,19 @@ }, { "sim":499.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":499.0, - "partner":"8w05" + "partner":"8w06" }, { "sim":490.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":490.0, - "partner":"8w08" + "partner":"8v0a" }, { "sim":53.0, @@ -896590,11 +900301,11 @@ }, { "sim":50.0, - "partner":"8jpa" + "partner":"8hdv" }, { "sim":50.0, - "partner":"8hdv" + "partner":"8jpa" }, { "sim":50.0, @@ -896708,11 +900419,11 @@ }, { "sim":343.0, - "partner":"8tim" + "partner":"1tph" }, { "sim":343.0, - "partner":"1tph" + "partner":"8tim" }, { "sim":343.0, @@ -896744,19 +900455,19 @@ }, { "sim":342.0, - "partner":"1r2s" + "partner":"4owg" }, { "sim":342.0, - "partner":"1r2t" + "partner":"1r2r" }, { "sim":342.0, - "partner":"4owg" + "partner":"1r2s" }, { "sim":342.0, - "partner":"1r2r" + "partner":"1r2t" }, { "sim":342.0, @@ -896876,15 +900587,15 @@ }, { "sim":314.0, - "partner":"8j7c" + "partner":"4gnj" }, { "sim":314.0, - "partner":"8jbp" + "partner":"8j7c" }, { "sim":314.0, - "partner":"4gnj" + "partner":"8jbp" }, { "sim":308.0, @@ -896896,15 +900607,15 @@ }, { "sim":303.0, - "partner":"2ypi" + "partner":"1ypi" }, { "sim":303.0, - "partner":"1ypi" + "partner":"7tim" }, { "sim":303.0, - "partner":"7tim" + "partner":"2ypi" }, { "sim":301.0, @@ -896920,11 +900631,11 @@ }, { "sim":295.0, - "partner":"1nf0" + "partner":"1ney" }, { "sim":295.0, - "partner":"1ney" + "partner":"1nf0" }, { "sim":287.0, @@ -896942,18 +900653,6 @@ "sim":284.0, "partner":"3qsr" }, - { - "sim":282.0, - "partner":"7az3" - }, - { - "sim":282.0, - "partner":"2vxn" - }, - { - "sim":282.0, - "partner":"7az4" - }, { "sim":282.0, "partner":"1n55" @@ -896980,16 +900679,28 @@ }, { "sim":282.0, - "partner":"1if2" + "partner":"7abx" }, { "sim":282.0, - "partner":"7abx" + "partner":"7az3" }, { "sim":282.0, "partner":"1qds" }, + { + "sim":282.0, + "partner":"7az4" + }, + { + "sim":282.0, + "partner":"1if2" + }, + { + "sim":282.0, + "partner":"2vxn" + }, { "sim":281.0, "partner":"4o4v" @@ -897016,15 +900727,15 @@ }, { "sim":279.0, - "partner":"4o50" + "partner":"4o54" }, { "sim":279.0, - "partner":"4o54" + "partner":"4o57" }, { "sim":279.0, - "partner":"4o57" + "partner":"4o50" }, { "sim":279.0, @@ -897078,10 +900789,6 @@ "sim":271.0, "partner":"1iig" }, - { - "sim":271.0, - "partner":"2v0t" - }, { "sim":271.0, "partner":"1iih" @@ -897112,15 +900819,19 @@ }, { "sim":271.0, - "partner":"4tim" + "partner":"2v0t" }, { "sim":271.0, - "partner":"2v5l" + "partner":"6tim" }, { "sim":271.0, - "partner":"6tim" + "partner":"4tim" + }, + { + "sim":271.0, + "partner":"2v5l" }, { "sim":270.0, @@ -897156,7 +900867,7 @@ }, { "sim":268.0, - "partner":"1kv5" + "partner":"5i3f" }, { "sim":268.0, @@ -897164,7 +900875,7 @@ }, { "sim":268.0, - "partner":"5i3f" + "partner":"1kv5" }, { "sim":266.0, @@ -897236,19 +900947,15 @@ }, { "sim":245.0, - "partner":"2vfd" + "partner":"4ywi" }, { "sim":245.0, - "partner":"2vfe" + "partner":"2vfd" }, { "sim":245.0, - "partner":"4ywi" - }, - { - "sim":244.0, - "partner":"1lzo" + "partner":"2vfe" }, { "sim":244.0, @@ -897284,15 +900991,11 @@ }, { "sim":244.0, - "partner":"1m7p" - }, - { - "sim":243.0, - "partner":"5gv4" + "partner":"1lzo" }, { - "sim":243.0, - "partner":"5gzp" + "sim":244.0, + "partner":"1m7p" }, { "sim":243.0, @@ -897318,6 +901021,14 @@ "sim":243.0, "partner":"5brb" }, + { + "sim":243.0, + "partner":"5gzp" + }, + { + "sim":243.0, + "partner":"5gv4" + }, { "sim":242.0, "partner":"2v2d" @@ -897442,10 +901153,6 @@ "sim":227.0, "partner":"4pc8" }, - { - "sim":222.0, - "partner":"3uwz" - }, { "sim":222.0, "partner":"3uwu" @@ -897462,17 +901169,21 @@ "sim":222.0, "partner":"3uwy" }, + { + "sim":222.0, + "partner":"3uwz" + }, { "sim":220.0, "partner":"7rpn" }, { "sim":216.0, - "partner":"4iot" + "partner":"1tre" }, { "sim":216.0, - "partner":"1tre" + "partner":"4iot" }, { "sim":213.0, @@ -897642,10 +901353,6 @@ "sim":57.0, "partner":"6njq" }, - { - "sim":57.0, - "partner":"5mit" - }, { "sim":57.0, "partner":"5mjk" @@ -897672,7 +901379,7 @@ }, { "sim":57.0, - "partner":"2cj9" + "partner":"5mit" }, { "sim":57.0, @@ -897687,44 +901394,44 @@ "partner":"2cjb" }, { - "sim":56.0, - "partner":"5y0f" + "sim":57.0, + "partner":"2cj9" }, { "sim":56.0, - "partner":"5y0g" + "partner":"4nns" }, { "sim":56.0, - "partner":"4nns" + "partner":"4nnt" }, { "sim":56.0, - "partner":"4nnt" + "partner":"6ljs" }, { "sim":56.0, - "partner":"5y12" + "partner":"6ljt" }, { "sim":56.0, - "partner":"6ljs" + "partner":"8wdx" }, { "sim":56.0, - "partner":"5d45" + "partner":"5y12" }, { "sim":56.0, - "partner":"5y13" + "partner":"6lju" }, { "sim":56.0, - "partner":"6ljt" + "partner":"5d45" }, { "sim":56.0, - "partner":"6lju" + "partner":"5y13" }, { "sim":56.0, @@ -897748,7 +901455,7 @@ }, { "sim":56.0, - "partner":"8wdx" + "partner":"8we3" }, { "sim":56.0, @@ -897760,11 +901467,15 @@ }, { "sim":56.0, - "partner":"8we3" + "partner":"5y0x" }, { "sim":56.0, - "partner":"5y0x" + "partner":"5y0f" + }, + { + "sim":56.0, + "partner":"5y0g" }, { "sim":56.0, @@ -897988,15 +901699,15 @@ }, { "sim":54.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":54.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":54.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":54.0, @@ -898044,15 +901755,15 @@ }, { "sim":54.0, - "partner":"8wov" + "partner":"8wop" }, { "sim":54.0, - "partner":"8wow" + "partner":"8wov" }, { "sim":54.0, - "partner":"8wop" + "partner":"8wow" }, { "sim":54.0, @@ -898176,15 +901887,15 @@ }, { "sim":53.0, - "partner":"3th5" + "partner":"4gzl" }, { "sim":53.0, - "partner":"4gzl" + "partner":"4gzm" }, { "sim":53.0, - "partner":"4gzm" + "partner":"3th5" }, { "sim":53.0, @@ -898198,10 +901909,6 @@ "sim":53.0, "partner":"3ofv" }, - { - "sim":53.0, - "partner":"6ueo" - }, { "sim":53.0, "partner":"6uep" @@ -898216,11 +901923,11 @@ }, { "sim":53.0, - "partner":"3l4c" + "partner":"6ueo" }, { "sim":53.0, - "partner":"6j0l" + "partner":"3l4c" }, { "sim":53.0, @@ -898232,19 +901939,19 @@ }, { "sim":53.0, - "partner":"1ku1" + "partner":"6j0l" }, { "sim":53.0, - "partner":"7o2t" + "partner":"1ku1" }, { "sim":53.0, - "partner":"7o2u" + "partner":"6z17" }, { "sim":53.0, - "partner":"6z17" + "partner":"7o2u" }, { "sim":53.0, @@ -898262,6 +901969,10 @@ "sim":53.0, "partner":"6z5k" }, + { + "sim":53.0, + "partner":"7o2t" + }, { "sim":53.0, "partner":"2brx" @@ -898288,23 +901999,23 @@ }, { "sim":53.0, - "partner":"6ihr" + "partner":"6ihv" }, { "sim":53.0, - "partner":"6iht" + "partner":"6ihw" }, { "sim":53.0, - "partner":"6ihu" + "partner":"6ihr" }, { "sim":53.0, - "partner":"6ihv" + "partner":"6iht" }, { "sim":53.0, - "partner":"6ihw" + "partner":"6ihu" }, { "sim":53.0, @@ -898356,11 +902067,11 @@ }, { "sim":53.0, - "partner":"3la8" + "partner":"3lba" }, { "sim":53.0, - "partner":"3lba" + "partner":"3la8" }, { "sim":53.0, @@ -898432,15 +902143,15 @@ }, { "sim":53.0, - "partner":"7mdl" + "partner":"8g9z" }, { "sim":53.0, - "partner":"8g9z" + "partner":"7l1t" }, { "sim":53.0, - "partner":"7l1t" + "partner":"7mdl" }, { "sim":53.0, @@ -898448,11 +902159,11 @@ }, { "sim":53.0, - "partner":"2vbg" + "partner":"2vbf" }, { "sim":53.0, - "partner":"2vbf" + "partner":"2vbg" }, { "sim":53.0, @@ -898488,16 +902199,12 @@ }, { "sim":53.0, - "partner":"5uw0" + "partner":"5uw1" }, { "sim":53.0, "partner":"5vnc" }, - { - "sim":53.0, - "partner":"5uw1" - }, { "sim":53.0, "partner":"5uw4" @@ -898508,7 +902215,7 @@ }, { "sim":53.0, - "partner":"3rsz" + "partner":"5uw0" }, { "sim":53.0, @@ -898538,6 +902245,10 @@ "sim":53.0, "partner":"3nch" }, + { + "sim":53.0, + "partner":"3rsz" + }, { "sim":53.0, "partner":"3slk" @@ -898574,10 +902285,6 @@ "sim":52.0, "partner":"1w6v" }, - { - "sim":52.0, - "partner":"5zrk" - }, { "sim":52.0, "partner":"5zrl" @@ -898606,6 +902313,10 @@ "sim":52.0, "partner":"5zri" }, + { + "sim":52.0, + "partner":"5zrk" + }, { "sim":52.0, "partner":"3oq0" @@ -898624,11 +902335,11 @@ }, { "sim":52.0, - "partner":"1x24" + "partner":"1zcl" }, { "sim":52.0, - "partner":"1zcl" + "partner":"1x24" }, { "sim":52.0, @@ -898660,11 +902371,11 @@ }, { "sim":52.0, - "partner":"3oci" + "partner":"3oc3" }, { "sim":52.0, - "partner":"3oc3" + "partner":"3oci" }, { "sim":52.0, @@ -898676,27 +902387,27 @@ }, { "sim":52.0, - "partner":"4bmx" + "partner":"4bmz" }, { "sim":52.0, - "partner":"4bmy" + "partner":"4bn0" }, { "sim":52.0, - "partner":"4bmz" + "partner":"4bmx" }, { "sim":52.0, - "partner":"4bn0" + "partner":"4bmy" }, { "sim":52.0, - "partner":"5h5a" + "partner":"5h54" }, { "sim":52.0, - "partner":"5h54" + "partner":"5h5a" }, { "sim":52.0, @@ -898744,23 +902455,23 @@ }, { "sim":52.0, - "partner":"6mql" + "partner":"6mqb" }, { "sim":52.0, - "partner":"6mq9" + "partner":"6mqk" }, { "sim":52.0, - "partner":"6mqb" + "partner":"1xse" }, { "sim":52.0, - "partner":"1xse" + "partner":"6mql" }, { "sim":52.0, - "partner":"6mqk" + "partner":"6mq9" }, { "sim":52.0, @@ -898796,15 +902507,15 @@ }, { "sim":52.0, - "partner":"4w7v" + "partner":"4w7u" }, { "sim":52.0, - "partner":"4w7w" + "partner":"4w7v" }, { "sim":52.0, - "partner":"4w7u" + "partner":"4w7w" }, { "sim":52.0, @@ -898816,11 +902527,11 @@ }, { "sim":52.0, - "partner":"7js3" + "partner":"8g5w" }, { "sim":52.0, - "partner":"8g5w" + "partner":"7js3" }, { "sim":52.0, @@ -898858,10 +902569,6 @@ "sim":52.0, "partner":"4rhq" }, - { - "sim":52.0, - "partner":"5g6t" - }, { "sim":52.0, "partner":"5g5u" @@ -898890,6 +902597,10 @@ "sim":52.0, "partner":"5g5k" }, + { + "sim":52.0, + "partner":"5g6t" + }, { "sim":52.0, "partner":"3kzm" @@ -898942,22 +902653,6 @@ "sim":52.0, "partner":"3kzk" }, - { - "sim":52.0, - "partner":"7wxl" - }, - { - "sim":52.0, - "partner":"7wxm" - }, - { - "sim":52.0, - "partner":"7wxn" - }, - { - "sim":52.0, - "partner":"7wxo" - }, { "sim":52.0, "partner":"7wxp" @@ -898988,7 +902683,19 @@ }, { "sim":52.0, - "partner":"5hxu" + "partner":"7wxl" + }, + { + "sim":52.0, + "partner":"7wxm" + }, + { + "sim":52.0, + "partner":"7wxn" + }, + { + "sim":52.0, + "partner":"7wxo" }, { "sim":52.0, @@ -899002,6 +902709,10 @@ "sim":52.0, "partner":"5hwe" }, + { + "sim":52.0, + "partner":"5hxu" + }, { "sim":52.0, "partner":"4r9v" @@ -899072,51 +902783,51 @@ }, { "sim":52.0, - "partner":"4gyk" + "partner":"4gyj" }, { "sim":52.0, - "partner":"4gyj" + "partner":"4gyk" }, { "sim":52.0, - "partner":"2yii" + "partner":"4c5u" }, { "sim":52.0, - "partner":"4c5s" + "partner":"4cq5" }, { "sim":52.0, - "partner":"4v2r" + "partner":"4baa" }, { "sim":52.0, - "partner":"4c5u" + "partner":"4c6g" }, { "sim":52.0, - "partner":"4cq5" + "partner":"4bab" }, { "sim":52.0, - "partner":"4baa" + "partner":"4c5r" }, { "sim":52.0, - "partner":"4c6g" + "partner":"2yii" }, { "sim":52.0, - "partner":"4bab" + "partner":"4v2q" }, { "sim":52.0, - "partner":"4c5r" + "partner":"4c5s" }, { "sim":52.0, - "partner":"4v2q" + "partner":"4v2r" }, { "sim":52.0, @@ -899178,10 +902889,6 @@ "sim":51.0, "partner":"3ctg" }, - { - "sim":51.0, - "partner":"4hmr" - }, { "sim":51.0, "partner":"4hls" @@ -899194,6 +902901,10 @@ "sim":51.0, "partner":"1yx3" }, + { + "sim":51.0, + "partner":"4hmr" + }, { "sim":51.0, "partner":"2lea" @@ -899314,10 +903025,6 @@ "sim":51.0, "partner":"6gum" }, - { - "sim":51.0, - "partner":"3l1u" - }, { "sim":51.0, "partner":"3l1v" @@ -899334,6 +903041,10 @@ "sim":51.0, "partner":"3esr" }, + { + "sim":51.0, + "partner":"3l1u" + }, { "sim":51.0, "partner":"4kce" @@ -899482,14 +903193,6 @@ "sim":51.0, "partner":"5vrc" }, - { - "sim":51.0, - "partner":"3quo" - }, - { - "sim":51.0, - "partner":"3qvf" - }, { "sim":51.0, "partner":"3qur" @@ -899520,7 +903223,11 @@ }, { "sim":51.0, - "partner":"4rdh" + "partner":"3quo" + }, + { + "sim":51.0, + "partner":"3qvf" }, { "sim":51.0, @@ -899532,19 +903239,19 @@ }, { "sim":51.0, - "partner":"5bwl" + "partner":"4rdh" }, { "sim":51.0, - "partner":"6m09" + "partner":"5bwl" }, { "sim":51.0, - "partner":"6m0a" + "partner":"6m09" }, { "sim":51.0, - "partner":"6wye" + "partner":"6m0a" }, { "sim":51.0, @@ -899558,6 +903265,10 @@ "sim":51.0, "partner":"4ats" }, + { + "sim":51.0, + "partner":"6wye" + }, { "sim":51.0, "partner":"7umj" @@ -899592,11 +903303,11 @@ }, { "sim":51.0, - "partner":"6aa8" + "partner":"7eov" }, { "sim":51.0, - "partner":"7eov" + "partner":"6aa8" }, { "sim":51.0, @@ -899606,10 +903317,6 @@ "sim":51.0, "partner":"5dz7" }, - { - "sim":51.0, - "partner":"8wlb" - }, { "sim":51.0, "partner":"8wl5" @@ -899624,19 +903331,19 @@ }, { "sim":51.0, - "partner":"3zgc" + "partner":"8wlb" }, { "sim":51.0, - "partner":"3zgd" + "partner":"3zgc" }, { "sim":51.0, - "partner":"6toe" + "partner":"3zgd" }, { "sim":51.0, - "partner":"3g3d" + "partner":"6toe" }, { "sim":51.0, @@ -899656,51 +903363,55 @@ }, { "sim":51.0, - "partner":"7q2b" + "partner":"3g3d" }, { "sim":51.0, - "partner":"3ha3" + "partner":"7q2f" }, { "sim":51.0, - "partner":"7q2c" + "partner":"7q2g" }, { "sim":51.0, - "partner":"7q2d" + "partner":"7q2h" }, { "sim":51.0, - "partner":"7q2e" + "partner":"3ha5" }, { "sim":51.0, - "partner":"7q2f" + "partner":"2fk7" }, { "sim":51.0, - "partner":"7q2g" + "partner":"2fk8" }, { "sim":51.0, - "partner":"7q2h" + "partner":"3ha7" }, { "sim":51.0, - "partner":"3ha5" + "partner":"7q2b" }, { "sim":51.0, - "partner":"2fk7" + "partner":"7q2c" }, { "sim":51.0, - "partner":"2fk8" + "partner":"3ha3" }, { "sim":51.0, - "partner":"3ha7" + "partner":"7q2d" + }, + { + "sim":51.0, + "partner":"7q2e" }, { "sim":51.0, @@ -899842,14 +903553,6 @@ "sim":51.0, "partner":"4ig7" }, - { - "sim":51.0, - "partner":"4fif" - }, - { - "sim":51.0, - "partner":"7s46" - }, { "sim":51.0, "partner":"4fig" @@ -899900,7 +903603,11 @@ }, { "sim":51.0, - "partner":"6sf5" + "partner":"4fif" + }, + { + "sim":51.0, + "partner":"7s46" }, { "sim":51.0, @@ -899908,11 +903615,11 @@ }, { "sim":51.0, - "partner":"3ren" + "partner":"6sf5" }, { "sim":51.0, - "partner":"5l9l" + "partner":"3ren" }, { "sim":51.0, @@ -899934,6 +903641,10 @@ "sim":51.0, "partner":"5l9i" }, + { + "sim":51.0, + "partner":"5l9l" + }, { "sim":51.0, "partner":"5xm6" @@ -899950,10 +903661,6 @@ "sim":51.0, "partner":"5v8y" }, - { - "sim":51.0, - "partner":"5jyf" - }, { "sim":51.0, "partner":"5v8x" @@ -899982,6 +903689,10 @@ "sim":51.0, "partner":"5jye" }, + { + "sim":51.0, + "partner":"5jyf" + }, { "sim":51.0, "partner":"6nxc" @@ -900006,10 +903717,6 @@ "sim":51.0, "partner":"3txx" }, - { - "sim":51.0, - "partner":"8hmn" - }, { "sim":51.0, "partner":"7o9o" @@ -900020,15 +903727,15 @@ }, { "sim":51.0, - "partner":"8tne" + "partner":"8hmn" }, { "sim":51.0, - "partner":"7us5" + "partner":"8tne" }, { "sim":51.0, - "partner":"4m1i" + "partner":"7us5" }, { "sim":51.0, @@ -900042,6 +903749,10 @@ "sim":51.0, "partner":"4m1h" }, + { + "sim":51.0, + "partner":"4m1i" + }, { "sim":51.0, "partner":"4o6e" @@ -900058,10 +903769,6 @@ "sim":51.0, "partner":"3wnd" }, - { - "sim":51.0, - "partner":"3c1y" - }, { "sim":51.0, "partner":"3c1z" @@ -900088,7 +903795,7 @@ }, { "sim":51.0, - "partner":"4zhs" + "partner":"3c1y" }, { "sim":51.0, @@ -900096,19 +903803,19 @@ }, { "sim":51.0, - "partner":"4ltz" + "partner":"4zhs" }, { "sim":51.0, - "partner":"7kj8" + "partner":"3kbk" }, { "sim":51.0, - "partner":"7kj9" + "partner":"6ax9" }, { "sim":51.0, - "partner":"3kbk" + "partner":"7kjd" }, { "sim":51.0, @@ -900116,7 +903823,7 @@ }, { "sim":51.0, - "partner":"6ax9" + "partner":"7kje" }, { "sim":51.0, @@ -900124,39 +903831,31 @@ }, { "sim":51.0, - "partner":"8su2" - }, - { - "sim":51.0, - "partner":"8su3" - }, - { - "sim":51.0, - "partner":"7kjd" + "partner":"6axu" }, { "sim":51.0, - "partner":"8su4" + "partner":"7kjf" }, { "sim":51.0, - "partner":"6axu" + "partner":"8su2" }, { "sim":51.0, - "partner":"7kje" + "partner":"7kjg" }, { "sim":51.0, - "partner":"8su5" + "partner":"8su3" }, { "sim":51.0, - "partner":"7kjf" + "partner":"8v3k" }, { "sim":51.0, - "partner":"7kjg" + "partner":"8su4" }, { "sim":51.0, @@ -900164,11 +903863,11 @@ }, { "sim":51.0, - "partner":"3kb9" + "partner":"8su5" }, { "sim":51.0, - "partner":"8v3k" + "partner":"3kb9" }, { "sim":51.0, @@ -900208,7 +903907,15 @@ }, { "sim":51.0, - "partner":"3pz9" + "partner":"7kj8" + }, + { + "sim":51.0, + "partner":"4ltz" + }, + { + "sim":51.0, + "partner":"7kj9" }, { "sim":51.0, @@ -900234,6 +903941,10 @@ "sim":51.0, "partner":"3pzq" }, + { + "sim":51.0, + "partner":"3pz9" + }, { "sim":51.0, "partner":"3dkb" @@ -900260,11 +903971,11 @@ }, { "sim":51.0, - "partner":"2gqn" + "partner":"2fq6" }, { "sim":51.0, - "partner":"2fq6" + "partner":"2gqn" }, { "sim":51.0, @@ -900272,31 +903983,31 @@ }, { "sim":51.0, - "partner":"4euh" + "partner":"4eue" }, { "sim":51.0, - "partner":"4eue" + "partner":"4euf" }, { "sim":51.0, - "partner":"4euf" + "partner":"4euh" }, { "sim":51.0, - "partner":"5dvi" + "partner":"5dvj" }, { "sim":51.0, - "partner":"3l5a" + "partner":"5dvf" }, { "sim":51.0, - "partner":"5dvj" + "partner":"5dvi" }, { "sim":51.0, - "partner":"5dvf" + "partner":"3l5a" }, { "sim":51.0, @@ -900338,10 +904049,6 @@ "sim":51.0, "partner":"7ui4" }, - { - "sim":51.0, - "partner":"4q6q" - }, { "sim":51.0, "partner":"4q6m" @@ -900360,19 +904067,19 @@ }, { "sim":51.0, - "partner":"6v99" + "partner":"4q6q" }, { "sim":51.0, - "partner":"6v9a" + "partner":"6v96" }, { "sim":51.0, - "partner":"6v96" + "partner":"6v99" }, { "sim":51.0, - "partner":"2imc" + "partner":"6v9a" }, { "sim":51.0, @@ -900398,6 +904105,10 @@ "sim":51.0, "partner":"2imb" }, + { + "sim":51.0, + "partner":"2imc" + }, { "sim":51.0, "partner":"7n18" @@ -900426,10 +904137,6 @@ "sim":51.0, "partner":"4elc" }, - { - "sim":51.0, - "partner":"7lr2" - }, { "sim":51.0, "partner":"7lr6" @@ -900442,6 +904149,10 @@ "sim":51.0, "partner":"5xwb" }, + { + "sim":51.0, + "partner":"7lr2" + }, { "sim":51.0, "partner":"5ctt" @@ -900474,10 +904185,6 @@ "sim":51.0, "partner":"3cmj" }, - { - "sim":51.0, - "partner":"6oi8" - }, { "sim":51.0, "partner":"4mv1" @@ -900516,11 +904223,7 @@ }, { "sim":51.0, - "partner":"2gps" - }, - { - "sim":51.0, - "partner":"6oi9" + "partner":"6oi8" }, { "sim":51.0, @@ -900540,11 +904243,11 @@ }, { "sim":51.0, - "partner":"8u41" + "partner":"2gps" }, { "sim":51.0, - "partner":"8u42" + "partner":"6oi9" }, { "sim":51.0, @@ -900552,15 +904255,19 @@ }, { "sim":51.0, - "partner":"8ux5" + "partner":"8u41" }, { "sim":51.0, - "partner":"3oqc" + "partner":"8u42" }, { "sim":51.0, - "partner":"6x0h" + "partner":"8ux5" + }, + { + "sim":51.0, + "partner":"3oqc" }, { "sim":51.0, @@ -900578,6 +904285,10 @@ "sim":51.0, "partner":"6jzs" }, + { + "sim":51.0, + "partner":"6x0h" + }, { "sim":51.0, "partner":"5v2d" @@ -900596,15 +904307,15 @@ }, { "sim":51.0, - "partner":"4dqw" + "partner":"6gjv" }, { "sim":51.0, - "partner":"6gjv" + "partner":"6gk9" }, { "sim":51.0, - "partner":"6gk9" + "partner":"4dqw" }, { "sim":51.0, @@ -900714,10 +904425,6 @@ "sim":51.0, "partner":"4lh3" }, - { - "sim":51.0, - "partner":"5wm2" - }, { "sim":51.0, "partner":"5wm3" @@ -900738,6 +904445,10 @@ "sim":51.0, "partner":"5wm7" }, + { + "sim":51.0, + "partner":"5wm2" + }, { "sim":51.0, "partner":"3bdl" @@ -900748,7 +904459,7 @@ }, { "sim":51.0, - "partner":"5m12" + "partner":"6gwg" }, { "sim":51.0, @@ -900756,31 +904467,31 @@ }, { "sim":51.0, - "partner":"6gwf" + "partner":"6gta" }, { "sim":51.0, - "partner":"6gwg" + "partner":"5m16" }, { "sim":51.0, - "partner":"5m16" + "partner":"6gvd" }, { "sim":51.0, - "partner":"6gta" + "partner":"5m0x" }, { "sim":51.0, - "partner":"6gvd" + "partner":"6gx8" }, { "sim":51.0, - "partner":"5m0x" + "partner":"5m12" }, { "sim":51.0, - "partner":"6gx8" + "partner":"6gwf" }, { "sim":51.0, @@ -900820,11 +904531,11 @@ }, { "sim":51.0, - "partner":"3i39" + "partner":"7err" }, { "sim":51.0, - "partner":"7err" + "partner":"3i39" }, { "sim":51.0, @@ -900852,15 +904563,15 @@ }, { "sim":51.0, - "partner":"7w1c" + "partner":"7w1d" }, { "sim":51.0, - "partner":"7w1d" + "partner":"7w1e" }, { "sim":51.0, - "partner":"7w1e" + "partner":"7w1c" }, { "sim":51.0, @@ -900920,11 +904631,11 @@ }, { "sim":51.0, - "partner":"3l7r" + "partner":"3t0c" }, { "sim":51.0, - "partner":"3t0c" + "partner":"3l7r" }, { "sim":51.0, @@ -900996,11 +904707,11 @@ }, { "sim":50.0, - "partner":"2jop" + "partner":"1te4" }, { "sim":50.0, - "partner":"1te4" + "partner":"2jop" }, { "sim":50.0, @@ -901096,19 +904807,19 @@ }, { "sim":50.0, - "partner":"4gzc" + "partner":"4gzd" }, { "sim":50.0, - "partner":"4gzd" + "partner":"4gzc" }, { "sim":50.0, - "partner":"4ay3" + "partner":"6xgt" }, { "sim":50.0, - "partner":"6xgt" + "partner":"4ay3" }, { "sim":50.0, @@ -901120,15 +904831,15 @@ }, { "sim":50.0, - "partner":"2h16" + "partner":"8ar6" }, { "sim":50.0, - "partner":"8ar6" + "partner":"8ar9" }, { "sim":50.0, - "partner":"8ar9" + "partner":"2h16" }, { "sim":50.0, @@ -901346,10 +905057,6 @@ "sim":50.0, "partner":"6azo" }, - { - "sim":50.0, - "partner":"5tgs" - }, { "sim":50.0, "partner":"8w8h" @@ -901360,7 +905067,7 @@ }, { "sim":50.0, - "partner":"6t2r" + "partner":"5tgs" }, { "sim":50.0, @@ -901368,12 +905075,16 @@ }, { "sim":50.0, - "partner":"6ubb" + "partner":"6t2r" }, { "sim":50.0, "partner":"6ub8" }, + { + "sim":50.0, + "partner":"6ubb" + }, { "sim":50.0, "partner":"6uba" @@ -901410,10 +905121,6 @@ "sim":50.0, "partner":"5c12" }, - { - "sim":50.0, - "partner":"6hxo" - }, { "sim":50.0, "partner":"7lnt" @@ -901438,6 +905145,10 @@ "sim":50.0, "partner":"6hxn" }, + { + "sim":50.0, + "partner":"6hxo" + }, { "sim":50.0, "partner":"7n9d" @@ -901458,10 +905169,6 @@ "sim":50.0, "partner":"1u6h" }, - { - "sim":50.0, - "partner":"2wk1" - }, { "sim":50.0, "partner":"6ypa" @@ -901472,12 +905179,16 @@ }, { "sim":50.0, - "partner":"4rni" + "partner":"2wk1" }, { "sim":50.0, "partner":"4rnj" }, + { + "sim":50.0, + "partner":"4rni" + }, { "sim":50.0, "partner":"3jyy" @@ -901544,11 +905255,11 @@ }, { "sim":50.0, - "partner":"5lsg" + "partner":"6t9c" }, { "sim":50.0, - "partner":"6t9c" + "partner":"5lsg" }, { "sim":50.0, @@ -901562,10 +905273,6 @@ "sim":50.0, "partner":"8rej" }, - { - "sim":50.0, - "partner":"3s3h" - }, { "sim":50.0, "partner":"4gxn" @@ -901590,6 +905297,10 @@ "sim":50.0, "partner":"4gw3" }, + { + "sim":50.0, + "partner":"3s3h" + }, { "sim":50.0, "partner":"5dh0" @@ -901624,19 +905335,19 @@ }, { "sim":50.0, - "partner":"8u05" + "partner":"6l86" }, { "sim":50.0, - "partner":"8u06" + "partner":"8u05" }, { "sim":50.0, - "partner":"8u07" + "partner":"8u06" }, { "sim":50.0, - "partner":"6l86" + "partner":"8u07" }, { "sim":50.0, @@ -901682,17 +905393,13 @@ "sim":50.0, "partner":"3d7r" }, - { - "sim":50.0, - "partner":"5z75" - }, { "sim":50.0, "partner":"3utn" }, { "sim":50.0, - "partner":"2pzm" + "partner":"5z75" }, { "sim":50.0, @@ -901704,20 +905411,24 @@ }, { "sim":50.0, - "partner":"6lcn" + "partner":"2pzm" }, { "sim":50.0, - "partner":"7btm" + "partner":"7bsx" }, { "sim":50.0, - "partner":"7bsx" + "partner":"7btm" }, { "sim":50.0, "partner":"3h7r" }, + { + "sim":50.0, + "partner":"6lcn" + }, { "sim":50.0, "partner":"4zck" @@ -901758,14 +905469,6 @@ "sim":50.0, "partner":"2f9y" }, - { - "sim":50.0, - "partner":"5tyq" - }, - { - "sim":50.0, - "partner":"5u19" - }, { "sim":50.0, "partner":"5u0n" @@ -901794,6 +905497,14 @@ "sim":50.0, "partner":"5u1i" }, + { + "sim":50.0, + "partner":"5tyq" + }, + { + "sim":50.0, + "partner":"5u19" + }, { "sim":50.0, "partner":"3civ" @@ -901822,10 +905533,6 @@ "sim":50.0, "partner":"4ypv" }, - { - "sim":50.0, - "partner":"7ajm" - }, { "sim":50.0, "partner":"7a4r" @@ -901844,31 +905551,15 @@ }, { "sim":50.0, - "partner":"7a19" - }, - { - "sim":50.0, - "partner":"7a1a" - }, - { - "sim":50.0, - "partner":"7a53" - }, - { - "sim":50.0, - "partner":"7ajw" - }, - { - "sim":50.0, - "partner":"7akb" + "partner":"7ajm" }, { "sim":50.0, - "partner":"7ajy" + "partner":"7a19" }, { "sim":50.0, - "partner":"7a5l" + "partner":"7a1a" }, { "sim":50.0, @@ -901930,10 +905621,30 @@ "sim":50.0, "partner":"7aka" }, + { + "sim":50.0, + "partner":"7a53" + }, { "sim":50.0, "partner":"7akl" }, + { + "sim":50.0, + "partner":"7ajw" + }, + { + "sim":50.0, + "partner":"7akb" + }, + { + "sim":50.0, + "partner":"7ajy" + }, + { + "sim":50.0, + "partner":"7a5l" + }, { "sim":50.0, "partner":"3tn3" @@ -902004,15 +905715,15 @@ }, { "sim":50.0, - "partner":"7f6d" + "partner":"8uat" }, { "sim":50.0, - "partner":"8uat" + "partner":"8uaj" }, { "sim":50.0, - "partner":"8uaj" + "partner":"7f6d" }, { "sim":50.0, @@ -902024,11 +905735,11 @@ }, { "sim":50.0, - "partner":"5f5m" + "partner":"5f5o" }, { "sim":50.0, - "partner":"5f5o" + "partner":"5f5m" }, { "sim":50.0, @@ -902038,10 +905749,6 @@ "sim":50.0, "partner":"4ot7" }, - { - "sim":50.0, - "partner":"6put" - }, { "sim":50.0, "partner":"6puw" @@ -902056,15 +905763,15 @@ }, { "sim":50.0, - "partner":"5u1c" + "partner":"6puz" }, { "sim":50.0, - "partner":"6puz" + "partner":"5u1c" }, { "sim":50.0, - "partner":"7azd" + "partner":"6put" }, { "sim":50.0, @@ -902098,13 +905805,17 @@ "sim":50.0, "partner":"7az8" }, + { + "sim":50.0, + "partner":"7azg" + }, { "sim":50.0, "partner":"5x06" }, { "sim":50.0, - "partner":"7azg" + "partner":"7azc" }, { "sim":50.0, @@ -902112,11 +905823,11 @@ }, { "sim":50.0, - "partner":"7azc" + "partner":"3ban" }, { "sim":50.0, - "partner":"3ban" + "partner":"7azd" }, { "sim":50.0, @@ -902124,11 +905835,11 @@ }, { "sim":50.0, - "partner":"6wa9" + "partner":"6wa6" }, { "sim":50.0, - "partner":"6wa6" + "partner":"6wa9" }, { "sim":50.0, @@ -902238,10 +905949,6 @@ "sim":50.0, "partner":"4bko" }, - { - "sim":50.0, - "partner":"5cu7" - }, { "sim":50.0, "partner":"4fdt" @@ -902254,6 +905961,10 @@ "sim":50.0, "partner":"5cx4" }, + { + "sim":50.0, + "partner":"5cu7" + }, { "sim":50.0, "partner":"6hr7" @@ -902268,15 +905979,15 @@ }, { "sim":50.0, - "partner":"7d88" + "partner":"8w72" }, { "sim":50.0, - "partner":"7d89" + "partner":"7d88" }, { "sim":50.0, - "partner":"8w72" + "partner":"7d89" }, { "sim":50.0, @@ -902334,10 +906045,6 @@ "sim":50.0, "partner":"3nmz" }, - { - "sim":50.0, - "partner":"7tfc" - }, { "sim":50.0, "partner":"7d4k" @@ -902350,6 +906057,10 @@ "sim":50.0, "partner":"7d4n" }, + { + "sim":50.0, + "partner":"7tfc" + }, { "sim":50.0, "partner":"4j1q" @@ -902358,6 +906069,18 @@ "sim":50.0, "partner":"4j1s" }, + { + "sim":50.0, + "partner":"8wn5" + }, + { + "sim":50.0, + "partner":"8wn6" + }, + { + "sim":50.0, + "partner":"8wna" + }, { "sim":50.0, "partner":"2hp0" @@ -902378,17 +906101,13 @@ "sim":50.0, "partner":"8tfc" }, - { - "sim":50.0, - "partner":"8ufj" - }, { "sim":50.0, "partner":"3s6k" }, { "sim":50.0, - "partner":"2wc4" + "partner":"8ufj" }, { "sim":50.0, @@ -902516,16 +906235,20 @@ }, { "sim":50.0, - "partner":"6j0u" + "partner":"2wc4" }, { "sim":50.0, - "partner":"6ak4" + "partner":"6j0u" }, { "sim":50.0, "partner":"6aej" }, + { + "sim":50.0, + "partner":"6ak4" + }, { "sim":50.0, "partner":"6wiu" @@ -902540,11 +906263,11 @@ }, { "sim":50.0, - "partner":"4dqv" + "partner":"4u5q" }, { "sim":50.0, - "partner":"4u5q" + "partner":"4dqv" }, { "sim":50.0, @@ -902570,10 +906293,6 @@ "sim":50.0, "partner":"3khz" }, - { - "sim":50.0, - "partner":"4ie7" - }, { "sim":50.0, "partner":"4cxw" @@ -902592,15 +906311,15 @@ }, { "sim":50.0, - "partner":"4idz" + "partner":"7e8z" }, { "sim":50.0, - "partner":"4ie0" + "partner":"4idz" }, { "sim":50.0, - "partner":"7e8z" + "partner":"4ie0" }, { "sim":50.0, @@ -902618,6 +906337,10 @@ "sim":50.0, "partner":"4qho" }, + { + "sim":50.0, + "partner":"4ie7" + }, { "sim":50.0, "partner":"6rim" @@ -902658,14 +906381,6 @@ "sim":50.0, "partner":"3n6r" }, - { - "sim":50.0, - "partner":"8aq3" - }, - { - "sim":50.0, - "partner":"8aq4" - }, { "sim":50.0, "partner":"7aci" @@ -902674,10 +906389,6 @@ "sim":50.0, "partner":"8b0k" }, - { - "sim":50.0, - "partner":"5n6h" - }, { "sim":50.0, "partner":"8b0l" @@ -902690,6 +906401,10 @@ "sim":50.0, "partner":"8b0n" }, + { + "sim":50.0, + "partner":"5n6h" + }, { "sim":50.0, "partner":"8b0o" @@ -902706,6 +906421,14 @@ "sim":50.0, "partner":"5n6l" }, + { + "sim":50.0, + "partner":"8aq3" + }, + { + "sim":50.0, + "partner":"8aq4" + }, { "sim":50.0, "partner":"7lha" @@ -902774,10 +906497,6 @@ "sim":50.0, "partner":"3i3l" }, - { - "sim":50.0, - "partner":"7rpw" - }, { "sim":50.0, "partner":"2hiv" @@ -902794,6 +906513,10 @@ "sim":50.0, "partner":"7rpo" }, + { + "sim":50.0, + "partner":"7rpw" + }, { "sim":50.0, "partner":"3tj1" @@ -902838,10 +906561,6 @@ "sim":50.0, "partner":"7p1g" }, - { - "sim":50.0, - "partner":"6edw" - }, { "sim":50.0, "partner":"6edz" @@ -902852,23 +906571,15 @@ }, { "sim":50.0, - "partner":"8bou" - }, - { - "sim":50.0, - "partner":"7p1h" - }, - { - "sim":50.0, - "partner":"3ahc" + "partner":"6edw" }, { "sim":50.0, - "partner":"3ahd" + "partner":"8bou" }, { "sim":50.0, - "partner":"3ahe" + "partner":"7p1h" }, { "sim":50.0, @@ -902892,19 +906603,23 @@ }, { "sim":50.0, - "partner":"5fau" + "partner":"3ahc" }, { "sim":50.0, - "partner":"6nd3" + "partner":"3ahd" }, { "sim":50.0, - "partner":"4j3t" + "partner":"3ahe" }, { "sim":50.0, - "partner":"4j3u" + "partner":"5fau" + }, + { + "sim":50.0, + "partner":"6nd3" }, { "sim":50.0, @@ -902924,7 +906639,11 @@ }, { "sim":50.0, - "partner":"5y1h" + "partner":"4j3t" + }, + { + "sim":50.0, + "partner":"4j3u" }, { "sim":50.0, @@ -902972,11 +906691,11 @@ }, { "sim":50.0, - "partner":"7s6b" + "partner":"5y1h" }, { "sim":50.0, - "partner":"7o3m" + "partner":"7s6b" }, { "sim":50.0, @@ -902988,11 +906707,11 @@ }, { "sim":50.0, - "partner":"7c6o" + "partner":"7o3m" }, { "sim":50.0, - "partner":"6yt0" + "partner":"7c6o" }, { "sim":50.0, @@ -903009,6 +906728,10 @@ { "sim":50.0, "partner":"6ytj" + }, + { + "sim":50.0, + "partner":"6yt0" } ], "struct_thr_sim_designed":[ @@ -903135,123 +906858,123 @@ ], "subtitle":"Crystal structure of the worst case of the reconstruction of the ancestral triosephosphate isomerase of the last opisthokont common ancestor obtained by maximum likelihood with pgh", "tags":[ - "triose phosphate isomerase", + "isomerase", "ancestral sequence reconstruction", - "isomerase" + "triose phosphate isomerase" ], "keywords":[ - "work", - "tims", - "analysis", - "evolution", - "unfolding", - "lineages", - "evidence", - "oligomers", - "monomeric", - "located", - "part", - "bonds", - "conserved", - "test", - "isomerase", - "physicochemical", "opisthokonts", - "protozoan", - "reconstruction", - "sequences", - "robustness", - "equilibrium", - "structure", - "monomer", - "applied", - "oligomer", - "resembles", - "unstable", - "spectroscopic", + "tot", + "hydrodynamic", + "well", + "opisthokonta", + "presence", + "differences", + "bottom", + "locatims", "locatim", - "structured", - "reversible", - "resembling", - "reached", - "similar", - "infer", - "obligated", - "calorimetric", + "unstable", + "parameters", + "resembles", + "physicochemical", + "study", "indicated", - "although", - "strongly", - "locatims", - "presence", - "used", - "ancestral", - "comparative", - "structures", - "transitions", - "function", + "unfolding", "showed", - "triosephosphate", - "intermediates", + "equilibrium", "extensive", + "test", + "catalytic", + "two", + "infer", + "lineages", + "similar", + "worst", + "reconstructed", "shows", - "coupled", + "conformational", + "isomerase", + "ones", + "intermediates", + "although", + "last", + "case", + "strongly", + "triosephosphate", + "stability", + "part", + "evidence", + "characterization", + "several", + "ancestral", "hydrogen", "inference", - "properties", - "previously", - "stability", - "monomers", - "bottom", + "found", + "reached", + "\u03b4g", + "resembling", + "evolution", "higher", - "common", - "worst", - "methodologies", - "catalytic", - "temperature", - "four", - "unf", "diverged", - "observed", - "several", - "melting", - "characterization", - "confidence", - "rather", - "\u03b4g", - "high", - "sequence", - "parameters", + "robustness", + "four", + "monomer", + "barrel", + "correlation", "increase", + "spectroscopic", + "calorimetric", + "work", + "used", "extant", - "notably", - "ancestor", - "ones", - "tim", - "hydrodynamic", + "different", + "transitions", + "monomers", + "properties", + "bonds", + "also", + "reversible", + "confidence", + "inactive", + "methodologies", + "oligomer", + "unf", "plausible", + "notably", + "sequence", + "applied", + "common", "3d", - "opisthokonta", - "conformational", - "estimated", - "also", - "study", + "analysis", + "coupled", + "sequences", + "comparative", + "conserved", + "rather", + "observed", + "structures", + "reconstruction", + "oligomers", + "previously", + "structured", + "structure", + "monomeric", "fungi", - "barrel", - "tot", - "well", - "last", - "different", - "found", - "two", - "reconstructed", - "inactive", + "scenario", + "temperature", + "biophysical", + "function", + "melting", + "obligated", "energetics", + "located", + "high", + "estimated", + "tim", + "tims", + "ancestor", "animals", - "differences", - "scenario", - "case", - "correlation", - "biophysical" + "protozoan" ], "release_date":"2024-09-04", "publication":"\"Stable monomers in the ancestral sequence reconstruction of the last opisthokont common ancestor of dimeric triosephosphate isomerase\", Protein Sci., 33, e5134-e5134", @@ -903288,19 +907011,19 @@ }, { "sim":522.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":522.0, - "partner":"8w05" + "partner":"8w06" }, { "sim":489.0, - "partner":"8v2w" + "partner":"8v09" }, { "sim":489.0, - "partner":"8v09" + "partner":"8v2w" }, { "sim":483.0, @@ -903316,11 +907039,11 @@ }, { "sim":51.0, - "partner":"8c66" + "partner":"8adx" }, { "sim":51.0, - "partner":"8adx" + "partner":"8c66" }, { "sim":50.0, @@ -903332,11 +907055,11 @@ }, { "sim":50.0, - "partner":"8jpa" + "partner":"8hdv" }, { "sim":50.0, - "partner":"8hdv" + "partner":"8jpa" }, { "sim":50.0, @@ -903434,11 +907157,11 @@ }, { "sim":344.0, - "partner":"8tim" + "partner":"1tph" }, { "sim":344.0, - "partner":"1tph" + "partner":"8tim" }, { "sim":344.0, @@ -903478,27 +907201,27 @@ }, { "sim":342.0, - "partner":"1r2s" + "partner":"4owg" }, { "sim":342.0, - "partner":"1r2t" + "partner":"4unl" }, { "sim":342.0, - "partner":"4owg" + "partner":"1r2r" }, { "sim":342.0, - "partner":"4unl" + "partner":"1hti" }, { "sim":342.0, - "partner":"1hti" + "partner":"1r2s" }, { "sim":342.0, - "partner":"1r2r" + "partner":"1r2t" }, { "sim":342.0, @@ -903626,27 +907349,27 @@ }, { "sim":312.0, - "partner":"8j7c" + "partner":"4gnj" }, { "sim":312.0, - "partner":"8jbp" + "partner":"8j7c" }, { "sim":312.0, - "partner":"4gnj" + "partner":"8jbp" }, { "sim":306.0, - "partner":"2ypi" + "partner":"1ypi" }, { "sim":306.0, - "partner":"1ypi" + "partner":"7tim" }, { "sim":306.0, - "partner":"7tim" + "partner":"2ypi" }, { "sim":304.0, @@ -903662,11 +907385,11 @@ }, { "sim":298.0, - "partner":"1nf0" + "partner":"1ney" }, { "sim":298.0, - "partner":"1ney" + "partner":"1nf0" }, { "sim":295.0, @@ -903686,11 +907409,11 @@ }, { "sim":281.0, - "partner":"4o50" + "partner":"4o53" }, { "sim":281.0, - "partner":"4o53" + "partner":"4o50" }, { "sim":280.0, @@ -903718,51 +907441,51 @@ }, { "sim":278.0, - "partner":"7az3" + "partner":"1n55" }, { "sim":278.0, - "partner":"2vxn" + "partner":"7az9" }, { "sim":278.0, - "partner":"7az4" + "partner":"7aza" }, { "sim":278.0, - "partner":"1n55" + "partner":"2y61" }, { "sim":278.0, - "partner":"7az9" + "partner":"2y62" }, { "sim":278.0, - "partner":"7aza" + "partner":"2y63" }, { "sim":278.0, - "partner":"2y61" + "partner":"7abx" }, { "sim":278.0, - "partner":"2y62" + "partner":"7az3" }, { "sim":278.0, - "partner":"2y63" + "partner":"1qds" }, { "sim":278.0, - "partner":"1if2" + "partner":"7az4" }, { "sim":278.0, - "partner":"7abx" + "partner":"1if2" }, { "sim":278.0, - "partner":"1qds" + "partner":"2vxn" }, { "sim":277.0, @@ -903792,10 +907515,6 @@ "sim":273.0, "partner":"1iig" }, - { - "sim":273.0, - "partner":"2v0t" - }, { "sim":273.0, "partner":"4jeq" @@ -903810,11 +907529,11 @@ }, { "sim":273.0, - "partner":"1ag1" + "partner":"2oma" }, { "sim":273.0, - "partner":"2oma" + "partner":"1ag1" }, { "sim":273.0, @@ -903834,15 +907553,19 @@ }, { "sim":273.0, - "partner":"4tim" + "partner":"2v0t" }, { "sim":273.0, - "partner":"2v5l" + "partner":"6tim" }, { "sim":273.0, - "partner":"6tim" + "partner":"4tim" + }, + { + "sim":273.0, + "partner":"2v5l" }, { "sim":273.0, @@ -903874,23 +907597,23 @@ }, { "sim":271.0, - "partner":"1kv5" + "partner":"5i3j" }, { "sim":271.0, - "partner":"5i3i" + "partner":"5i3k" }, { "sim":271.0, - "partner":"5i3j" + "partner":"5i3f" }, { "sim":271.0, - "partner":"5i3k" + "partner":"5i3i" }, { "sim":271.0, - "partner":"5i3f" + "partner":"1kv5" }, { "sim":271.0, @@ -903956,10 +907679,6 @@ "sim":257.0, "partner":"2vfe" }, - { - "sim":256.0, - "partner":"1lzo" - }, { "sim":256.0, "partner":"1lyx" @@ -903996,6 +907715,10 @@ "sim":256.0, "partner":"1m7o" }, + { + "sim":256.0, + "partner":"1lzo" + }, { "sim":256.0, "partner":"1m7p" @@ -904046,11 +907769,11 @@ }, { "sim":253.0, - "partner":"5gv4" + "partner":"5gzp" }, { "sim":253.0, - "partner":"5gzp" + "partner":"5gv4" }, { "sim":252.0, @@ -904180,10 +907903,6 @@ "sim":228.0, "partner":"4y96" }, - { - "sim":228.0, - "partner":"3uwz" - }, { "sim":228.0, "partner":"3uwu" @@ -904200,6 +907919,10 @@ "sim":228.0, "partner":"3uwy" }, + { + "sim":228.0, + "partner":"3uwz" + }, { "sim":222.0, "partner":"4mva" @@ -904226,11 +907949,11 @@ }, { "sim":210.0, - "partner":"4iot" + "partner":"1tre" }, { "sim":210.0, - "partner":"1tre" + "partner":"4iot" }, { "sim":204.0, @@ -904514,43 +908237,39 @@ }, { "sim":55.0, - "partner":"5y0f" - }, - { - "sim":55.0, - "partner":"5y0g" + "partner":"4nns" }, { "sim":55.0, - "partner":"4nns" + "partner":"4nnt" }, { "sim":55.0, - "partner":"4nnt" + "partner":"6ljs" }, { "sim":55.0, - "partner":"5y12" + "partner":"6ljt" }, { "sim":55.0, - "partner":"6ljs" + "partner":"8wdx" }, { "sim":55.0, - "partner":"5d45" + "partner":"5y12" }, { "sim":55.0, - "partner":"5y13" + "partner":"6lju" }, { "sim":55.0, - "partner":"6ljt" + "partner":"5d45" }, { "sim":55.0, - "partner":"6lju" + "partner":"5y13" }, { "sim":55.0, @@ -904574,7 +908293,7 @@ }, { "sim":55.0, - "partner":"8wdx" + "partner":"8we3" }, { "sim":55.0, @@ -904586,11 +908305,15 @@ }, { "sim":55.0, - "partner":"8we3" + "partner":"5y0x" }, { "sim":55.0, - "partner":"5y0x" + "partner":"5y0f" + }, + { + "sim":55.0, + "partner":"5y0g" }, { "sim":55.0, @@ -904608,10 +908331,6 @@ "sim":55.0, "partner":"8fuh" }, - { - "sim":55.0, - "partner":"3th5" - }, { "sim":55.0, "partner":"4gzl" @@ -904640,6 +908359,10 @@ "sim":55.0, "partner":"3zf6" }, + { + "sim":55.0, + "partner":"3th5" + }, { "sim":55.0, "partner":"8spb" @@ -904696,10 +908419,6 @@ "sim":55.0, "partner":"4xkm" }, - { - "sim":55.0, - "partner":"2cj9" - }, { "sim":55.0, "partner":"2cja" @@ -904712,6 +908431,10 @@ "sim":55.0, "partner":"2cjb" }, + { + "sim":55.0, + "partner":"2cj9" + }, { "sim":55.0, "partner":"5a6j" @@ -904778,11 +908501,11 @@ }, { "sim":54.0, - "partner":"3la8" + "partner":"3lba" }, { "sim":54.0, - "partner":"3lba" + "partner":"3la8" }, { "sim":54.0, @@ -904804,10 +908527,6 @@ "sim":54.0, "partner":"5v8y" }, - { - "sim":54.0, - "partner":"5jyf" - }, { "sim":54.0, "partner":"5v8x" @@ -904836,6 +908555,10 @@ "sim":54.0, "partner":"5jye" }, + { + "sim":54.0, + "partner":"5jyf" + }, { "sim":54.0, "partner":"1v33" @@ -904890,15 +908613,15 @@ }, { "sim":53.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":53.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":53.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":53.0, @@ -904986,15 +908709,15 @@ }, { "sim":53.0, - "partner":"6j0l" + "partner":"6j0g" }, { "sim":53.0, - "partner":"6j0g" + "partner":"6j0k" }, { "sim":53.0, - "partner":"6j0k" + "partner":"6j0l" }, { "sim":53.0, @@ -905010,23 +908733,23 @@ }, { "sim":53.0, - "partner":"6ihr" + "partner":"6ihv" }, { "sim":53.0, - "partner":"6iht" + "partner":"6ihw" }, { "sim":53.0, - "partner":"6ihu" + "partner":"6ihr" }, { "sim":53.0, - "partner":"6ihv" + "partner":"6iht" }, { "sim":53.0, - "partner":"6ihw" + "partner":"6ihu" }, { "sim":53.0, @@ -905092,10 +908815,6 @@ "sim":53.0, "partner":"3t95" }, - { - "sim":53.0, - "partner":"2ikf" - }, { "sim":53.0, "partner":"2q0c" @@ -905124,6 +908843,10 @@ "sim":53.0, "partner":"5kal" }, + { + "sim":53.0, + "partner":"2ikf" + }, { "sim":53.0, "partner":"8hmn" @@ -905144,10 +908867,6 @@ "sim":53.0, "partner":"4ocv" }, - { - "sim":53.0, - "partner":"3pz9" - }, { "sim":53.0, "partner":"3pzg" @@ -905172,6 +908891,10 @@ "sim":53.0, "partner":"3pzq" }, + { + "sim":53.0, + "partner":"3pz9" + }, { "sim":53.0, "partner":"4w61" @@ -905230,15 +908953,15 @@ }, { "sim":53.0, - "partner":"7mdl" + "partner":"8g9z" }, { "sim":53.0, - "partner":"8g9z" + "partner":"7l1t" }, { "sim":53.0, - "partner":"7l1t" + "partner":"7mdl" }, { "sim":53.0, @@ -905254,11 +908977,11 @@ }, { "sim":53.0, - "partner":"2vbg" + "partner":"2vbf" }, { "sim":53.0, - "partner":"2vbf" + "partner":"2vbg" }, { "sim":53.0, @@ -905320,10 +909043,6 @@ "sim":52.0, "partner":"7rrm" }, - { - "sim":52.0, - "partner":"5zrk" - }, { "sim":52.0, "partner":"5zrl" @@ -905352,6 +909071,10 @@ "sim":52.0, "partner":"5zri" }, + { + "sim":52.0, + "partner":"5zrk" + }, { "sim":52.0, "partner":"7xtl" @@ -905362,19 +909085,19 @@ }, { "sim":52.0, - "partner":"1x24" + "partner":"4gzd" }, { "sim":52.0, - "partner":"4gzc" + "partner":"1zcl" }, { "sim":52.0, - "partner":"4gzd" + "partner":"1x24" }, { "sim":52.0, - "partner":"1zcl" + "partner":"4gzc" }, { "sim":52.0, @@ -905406,11 +909129,11 @@ }, { "sim":52.0, - "partner":"6kz6" + "partner":"8be9" }, { "sim":52.0, - "partner":"8be9" + "partner":"6kz6" }, { "sim":52.0, @@ -905436,10 +909159,6 @@ "sim":52.0, "partner":"3vwv" }, - { - "sim":52.0, - "partner":"6ueo" - }, { "sim":52.0, "partner":"6uep" @@ -905452,6 +909171,10 @@ "sim":52.0, "partner":"6uer" }, + { + "sim":52.0, + "partner":"6ueo" + }, { "sim":52.0, "partner":"4wqo" @@ -905466,19 +909189,19 @@ }, { "sim":52.0, - "partner":"4bmx" + "partner":"4bmz" }, { "sim":52.0, - "partner":"4bmy" + "partner":"4bn0" }, { "sim":52.0, - "partner":"4bmz" + "partner":"4bmx" }, { "sim":52.0, - "partner":"4bn0" + "partner":"4bmy" }, { "sim":52.0, @@ -905552,10 +909275,6 @@ "sim":52.0, "partner":"5hru" }, - { - "sim":52.0, - "partner":"7dw8" - }, { "sim":52.0, "partner":"7dwa" @@ -905570,11 +909289,11 @@ }, { "sim":52.0, - "partner":"7js3" + "partner":"8g5w" }, { "sim":52.0, - "partner":"8g5w" + "partner":"7js3" }, { "sim":52.0, @@ -905584,13 +909303,17 @@ "sim":52.0, "partner":"7txa" }, + { + "sim":52.0, + "partner":"7dvj" + }, { "sim":52.0, "partner":"7txg" }, { "sim":52.0, - "partner":"7dvj" + "partner":"7dw8" }, { "sim":52.0, @@ -905616,10 +909339,6 @@ "sim":52.0, "partner":"4rhq" }, - { - "sim":52.0, - "partner":"5g6t" - }, { "sim":52.0, "partner":"5g5u" @@ -905650,11 +909369,11 @@ }, { "sim":52.0, - "partner":"5xmd" + "partner":"5g6t" }, { "sim":52.0, - "partner":"7ajm" + "partner":"5xmd" }, { "sim":52.0, @@ -905670,23 +909389,7 @@ }, { "sim":52.0, - "partner":"7a53" - }, - { - "sim":52.0, - "partner":"7ajw" - }, - { - "sim":52.0, - "partner":"7akb" - }, - { - "sim":52.0, - "partner":"7ajy" - }, - { - "sim":52.0, - "partner":"7a5l" + "partner":"7ajm" }, { "sim":52.0, @@ -905752,25 +909455,37 @@ "sim":52.0, "partner":"7aka" }, + { + "sim":52.0, + "partner":"7a53" + }, { "sim":52.0, "partner":"7akl" }, { "sim":52.0, - "partner":"5uqv" + "partner":"7ajw" }, { "sim":52.0, - "partner":"5uqx" + "partner":"7akb" }, { "sim":52.0, - "partner":"8wov" + "partner":"7ajy" }, { "sim":52.0, - "partner":"8wow" + "partner":"7a5l" + }, + { + "sim":52.0, + "partner":"5uqv" + }, + { + "sim":52.0, + "partner":"5uqx" }, { "sim":52.0, @@ -905778,7 +909493,11 @@ }, { "sim":52.0, - "partner":"3c1y" + "partner":"8wov" + }, + { + "sim":52.0, + "partner":"8wow" }, { "sim":52.0, @@ -905800,6 +909519,10 @@ "sim":52.0, "partner":"4yvz" }, + { + "sim":52.0, + "partner":"3c1y" + }, { "sim":52.0, "partner":"3rpl" @@ -905846,15 +909569,15 @@ }, { "sim":52.0, - "partner":"5dvi" + "partner":"5dvj" }, { "sim":52.0, - "partner":"5dvj" + "partner":"5dvf" }, { "sim":52.0, - "partner":"5dvf" + "partner":"5dvi" }, { "sim":52.0, @@ -905872,14 +909595,6 @@ "sim":52.0, "partner":"5y9h" }, - { - "sim":52.0, - "partner":"6mlh" - }, - { - "sim":52.0, - "partner":"6mlw" - }, { "sim":52.0, "partner":"6nn1" @@ -905904,6 +909619,14 @@ "sim":52.0, "partner":"6mlf" }, + { + "sim":52.0, + "partner":"6mlh" + }, + { + "sim":52.0, + "partner":"6mlw" + }, { "sim":52.0, "partner":"7dtp" @@ -906022,11 +909745,11 @@ }, { "sim":52.0, - "partner":"3l7r" + "partner":"3t0c" }, { "sim":52.0, - "partner":"3t0c" + "partner":"3l7r" }, { "sim":52.0, @@ -906076,10 +909799,6 @@ "sim":51.0, "partner":"2l6m" }, - { - "sim":51.0, - "partner":"4hmr" - }, { "sim":51.0, "partner":"4hls" @@ -906092,6 +909811,10 @@ "sim":51.0, "partner":"1yx3" }, + { + "sim":51.0, + "partner":"4hmr" + }, { "sim":51.0, "partner":"5h34" @@ -906114,11 +909837,11 @@ }, { "sim":51.0, - "partner":"6isk" + "partner":"6isl" }, { "sim":51.0, - "partner":"6isl" + "partner":"6isk" }, { "sim":51.0, @@ -906192,10 +909915,6 @@ "sim":51.0, "partner":"5e3b" }, - { - "sim":51.0, - "partner":"7ccl" - }, { "sim":51.0, "partner":"7ccm" @@ -906216,6 +909935,10 @@ "sim":51.0, "partner":"7efx" }, + { + "sim":51.0, + "partner":"7ccl" + }, { "sim":51.0, "partner":"5zba" @@ -906276,10 +909999,6 @@ "sim":51.0, "partner":"2iss" }, - { - "sim":51.0, - "partner":"3l1u" - }, { "sim":51.0, "partner":"3l1v" @@ -906300,6 +910019,10 @@ "sim":51.0, "partner":"3esr" }, + { + "sim":51.0, + "partner":"3l1u" + }, { "sim":51.0, "partner":"6a4c" @@ -906314,15 +910037,15 @@ }, { "sim":51.0, - "partner":"3wyd" + "partner":"7rm7" }, { "sim":51.0, - "partner":"7rm7" + "partner":"7snb" }, { "sim":51.0, - "partner":"7snb" + "partner":"3wyd" }, { "sim":51.0, @@ -906350,19 +910073,19 @@ }, { "sim":51.0, - "partner":"8vip" + "partner":"8vit" }, { "sim":51.0, - "partner":"8viq" + "partner":"8vip" }, { "sim":51.0, - "partner":"8vir" + "partner":"8viq" }, { "sim":51.0, - "partner":"8vit" + "partner":"8vir" }, { "sim":51.0, @@ -906422,11 +910145,11 @@ }, { "sim":51.0, - "partner":"5h5a" + "partner":"5h54" }, { "sim":51.0, - "partner":"5h54" + "partner":"5h5a" }, { "sim":51.0, @@ -906548,14 +910271,6 @@ "sim":51.0, "partner":"3u4d" }, - { - "sim":51.0, - "partner":"3quo" - }, - { - "sim":51.0, - "partner":"3qvf" - }, { "sim":51.0, "partner":"3qur" @@ -906584,6 +910299,14 @@ "sim":51.0, "partner":"3qun" }, + { + "sim":51.0, + "partner":"3quo" + }, + { + "sim":51.0, + "partner":"3qvf" + }, { "sim":51.0, "partner":"3jyy" @@ -906644,10 +910367,6 @@ "sim":51.0, "partner":"6m0a" }, - { - "sim":51.0, - "partner":"6wye" - }, { "sim":51.0, "partner":"2jfo" @@ -906668,6 +910387,10 @@ "sim":51.0, "partner":"4ats" }, + { + "sim":51.0, + "partner":"6wye" + }, { "sim":51.0, "partner":"7umj" @@ -906714,11 +910437,11 @@ }, { "sim":51.0, - "partner":"6aa8" + "partner":"7eov" }, { "sim":51.0, - "partner":"7eov" + "partner":"6aa8" }, { "sim":51.0, @@ -906730,35 +910453,35 @@ }, { "sim":51.0, - "partner":"7xif" + "partner":"7xig" }, { "sim":51.0, - "partner":"8wlb" + "partner":"8wl5" }, { "sim":51.0, - "partner":"7xig" + "partner":"8wl7" }, { "sim":51.0, - "partner":"7xih" + "partner":"8wl9" }, { "sim":51.0, - "partner":"7xii" + "partner":"7xih" }, { "sim":51.0, - "partner":"8wl5" + "partner":"8wlb" }, { "sim":51.0, - "partner":"8wl7" + "partner":"7xii" }, { "sim":51.0, - "partner":"8wl9" + "partner":"7xif" }, { "sim":51.0, @@ -906770,11 +910493,11 @@ }, { "sim":51.0, - "partner":"3zgd" + "partner":"7dt2" }, { "sim":51.0, - "partner":"7dt2" + "partner":"3zgd" }, { "sim":51.0, @@ -906794,51 +910517,51 @@ }, { "sim":51.0, - "partner":"7q2b" + "partner":"7q2f" }, { "sim":51.0, - "partner":"3ha3" + "partner":"7q2g" }, { "sim":51.0, - "partner":"7q2c" + "partner":"7q2h" }, { "sim":51.0, - "partner":"7q2d" + "partner":"3ha5" }, { "sim":51.0, - "partner":"7q2e" + "partner":"2fk7" }, { "sim":51.0, - "partner":"7q2f" + "partner":"2fk8" }, { "sim":51.0, - "partner":"7q2g" + "partner":"3ha7" }, { "sim":51.0, - "partner":"7q2h" + "partner":"7q2b" }, { "sim":51.0, - "partner":"3ha5" + "partner":"7q2c" }, { "sim":51.0, - "partner":"2fk7" + "partner":"3ha3" }, { "sim":51.0, - "partner":"2fk8" + "partner":"7q2d" }, { "sim":51.0, - "partner":"3ha7" + "partner":"7q2e" }, { "sim":51.0, @@ -906948,10 +910671,6 @@ "sim":51.0, "partner":"7ohn" }, - { - "sim":51.0, - "partner":"5mit" - }, { "sim":51.0, "partner":"5mjk" @@ -906978,15 +910697,11 @@ }, { "sim":51.0, - "partner":"7x1l" - }, - { - "sim":51.0, - "partner":"4w7v" + "partner":"5mit" }, { "sim":51.0, - "partner":"4w7w" + "partner":"7x1l" }, { "sim":51.0, @@ -907008,6 +910723,14 @@ "sim":51.0, "partner":"4w7u" }, + { + "sim":51.0, + "partner":"4w7v" + }, + { + "sim":51.0, + "partner":"4w7w" + }, { "sim":51.0, "partner":"6q75" @@ -907060,14 +910783,6 @@ "sim":51.0, "partner":"5hpc" }, - { - "sim":51.0, - "partner":"4fif" - }, - { - "sim":51.0, - "partner":"7s46" - }, { "sim":51.0, "partner":"4fig" @@ -907110,11 +910825,11 @@ }, { "sim":51.0, - "partner":"3rny" + "partner":"6wlx" }, { "sim":51.0, - "partner":"6wlx" + "partner":"3rny" }, { "sim":51.0, @@ -907122,12 +910837,20 @@ }, { "sim":51.0, - "partner":"6sf5" + "partner":"4fif" + }, + { + "sim":51.0, + "partner":"7s46" }, { "sim":51.0, "partner":"6sf4" }, + { + "sim":51.0, + "partner":"6sf5" + }, { "sim":51.0, "partner":"3ren" @@ -907256,10 +910979,6 @@ "sim":51.0, "partner":"7us5" }, - { - "sim":51.0, - "partner":"4m1i" - }, { "sim":51.0, "partner":"4d8f" @@ -907274,19 +910993,7 @@ }, { "sim":51.0, - "partner":"7wxl" - }, - { - "sim":51.0, - "partner":"7wxm" - }, - { - "sim":51.0, - "partner":"7wxn" - }, - { - "sim":51.0, - "partner":"7wxo" + "partner":"4m1i" }, { "sim":51.0, @@ -907316,6 +911023,22 @@ "sim":51.0, "partner":"7wxk" }, + { + "sim":51.0, + "partner":"7wxl" + }, + { + "sim":51.0, + "partner":"7wxm" + }, + { + "sim":51.0, + "partner":"7wxn" + }, + { + "sim":51.0, + "partner":"7wxo" + }, { "sim":51.0, "partner":"4o6e" @@ -907334,11 +911057,11 @@ }, { "sim":51.0, - "partner":"5f5m" + "partner":"5f5o" }, { "sim":51.0, - "partner":"5f5o" + "partner":"5f5m" }, { "sim":51.0, @@ -907348,10 +911071,6 @@ "sim":51.0, "partner":"2yvk" }, - { - "sim":51.0, - "partner":"4zhs" - }, { "sim":51.0, "partner":"4oco" @@ -907378,19 +911097,19 @@ }, { "sim":51.0, - "partner":"4ltz" + "partner":"4zhs" }, { "sim":51.0, - "partner":"7kj8" + "partner":"3kbk" }, { "sim":51.0, - "partner":"7kj9" + "partner":"6ax9" }, { "sim":51.0, - "partner":"3kbk" + "partner":"7kjd" }, { "sim":51.0, @@ -907398,7 +911117,7 @@ }, { "sim":51.0, - "partner":"6ax9" + "partner":"7kje" }, { "sim":51.0, @@ -907406,39 +911125,31 @@ }, { "sim":51.0, - "partner":"8su2" - }, - { - "sim":51.0, - "partner":"8su3" - }, - { - "sim":51.0, - "partner":"7kjd" + "partner":"6axu" }, { "sim":51.0, - "partner":"8su4" + "partner":"7kjf" }, { "sim":51.0, - "partner":"6axu" + "partner":"8su2" }, { "sim":51.0, - "partner":"7kje" + "partner":"7kjg" }, { "sim":51.0, - "partner":"8su5" + "partner":"8su3" }, { "sim":51.0, - "partner":"7kjf" + "partner":"8v3k" }, { "sim":51.0, - "partner":"7kjg" + "partner":"8su4" }, { "sim":51.0, @@ -907446,11 +911157,11 @@ }, { "sim":51.0, - "partner":"3kb9" + "partner":"8su5" }, { "sim":51.0, - "partner":"8v3k" + "partner":"3kb9" }, { "sim":51.0, @@ -907488,6 +911199,18 @@ "sim":51.0, "partner":"4luu" }, + { + "sim":51.0, + "partner":"7kj8" + }, + { + "sim":51.0, + "partner":"4ltz" + }, + { + "sim":51.0, + "partner":"7kj9" + }, { "sim":51.0, "partner":"3fvm" @@ -907544,21 +911267,17 @@ "sim":51.0, "partner":"3k01" }, - { - "sim":51.0, - "partner":"2gqn" - }, { "sim":51.0, "partner":"2fq6" }, { "sim":51.0, - "partner":"7bvt" + "partner":"2gqn" }, { "sim":51.0, - "partner":"4euh" + "partner":"7bvt" }, { "sim":51.0, @@ -907576,6 +911295,10 @@ "sim":51.0, "partner":"4euf" }, + { + "sim":51.0, + "partner":"4euh" + }, { "sim":51.0, "partner":"5hxk" @@ -907612,10 +911335,6 @@ "sim":51.0, "partner":"7ui4" }, - { - "sim":51.0, - "partner":"4q6q" - }, { "sim":51.0, "partner":"4q6m" @@ -907634,24 +911353,28 @@ }, { "sim":51.0, - "partner":"6v99" + "partner":"4q6q" }, { "sim":51.0, - "partner":"6v9a" + "partner":"6v96" }, { "sim":51.0, - "partner":"6v96" + "partner":"6v99" }, { "sim":51.0, - "partner":"7lr2" + "partner":"6v9a" }, { "sim":51.0, "partner":"7lr1" }, + { + "sim":51.0, + "partner":"7lr2" + }, { "sim":51.0, "partner":"5ctt" @@ -907696,10 +911419,6 @@ "sim":51.0, "partner":"7tf9" }, - { - "sim":51.0, - "partner":"6oi8" - }, { "sim":51.0, "partner":"4mv1" @@ -907738,11 +911457,7 @@ }, { "sim":51.0, - "partner":"2gps" - }, - { - "sim":51.0, - "partner":"6oi9" + "partner":"6oi8" }, { "sim":51.0, @@ -907760,6 +911475,14 @@ "sim":51.0, "partner":"6pso" }, + { + "sim":51.0, + "partner":"2gps" + }, + { + "sim":51.0, + "partner":"6oi9" + }, { "sim":51.0, "partner":"6wiu" @@ -907774,15 +911497,15 @@ }, { "sim":51.0, - "partner":"6x0h" + "partner":"6x0j" }, { "sim":51.0, - "partner":"6x0j" + "partner":"6x0k" }, { "sim":51.0, - "partner":"6x0k" + "partner":"6x0h" }, { "sim":51.0, @@ -907810,15 +911533,15 @@ }, { "sim":51.0, - "partner":"4dqw" + "partner":"6gjv" }, { "sim":51.0, - "partner":"6gjv" + "partner":"6gk9" }, { "sim":51.0, - "partner":"6gk9" + "partner":"4dqw" }, { "sim":51.0, @@ -907888,10 +911611,6 @@ "sim":51.0, "partner":"6gnf" }, - { - "sim":51.0, - "partner":"5wm2" - }, { "sim":51.0, "partner":"5wm3" @@ -907912,6 +911631,10 @@ "sim":51.0, "partner":"5wm7" }, + { + "sim":51.0, + "partner":"5wm2" + }, { "sim":51.0, "partner":"3bdl" @@ -907946,11 +911669,11 @@ }, { "sim":51.0, - "partner":"3i39" + "partner":"7err" }, { "sim":51.0, - "partner":"7err" + "partner":"3i39" }, { "sim":51.0, @@ -908046,35 +911769,35 @@ }, { "sim":51.0, - "partner":"3ahc" + "partner":"3ahf" }, { "sim":51.0, - "partner":"3ahd" + "partner":"3ahg" }, { "sim":51.0, - "partner":"3ahe" + "partner":"3ahh" }, { "sim":51.0, - "partner":"3ahf" + "partner":"3ahi" }, { "sim":51.0, - "partner":"3ahg" + "partner":"3ahj" }, { "sim":51.0, - "partner":"3ahh" + "partner":"3ahc" }, { "sim":51.0, - "partner":"3ahi" + "partner":"3ahd" }, { "sim":51.0, - "partner":"3ahj" + "partner":"3ahe" }, { "sim":51.0, @@ -908182,11 +911905,11 @@ }, { "sim":50.0, - "partner":"2jop" + "partner":"1te4" }, { "sim":50.0, - "partner":"1te4" + "partner":"2jop" }, { "sim":50.0, @@ -908238,11 +911961,11 @@ }, { "sim":50.0, - "partner":"3n39" + "partner":"3n3a" }, { "sim":50.0, - "partner":"3n3a" + "partner":"6lyx" }, { "sim":50.0, @@ -908250,11 +911973,11 @@ }, { "sim":50.0, - "partner":"6lyx" + "partner":"4elz" }, { "sim":50.0, - "partner":"4elz" + "partner":"3n39" }, { "sim":50.0, @@ -908456,10 +912179,6 @@ "sim":50.0, "partner":"2ntm" }, - { - "sim":50.0, - "partner":"5wps" - }, { "sim":50.0, "partner":"5wpu" @@ -908492,6 +912211,10 @@ "sim":50.0, "partner":"5wpr" }, + { + "sim":50.0, + "partner":"5wps" + }, { "sim":50.0, "partner":"4ykb" @@ -908572,10 +912295,6 @@ "sim":50.0, "partner":"5owf" }, - { - "sim":50.0, - "partner":"5tgs" - }, { "sim":50.0, "partner":"8w8h" @@ -908586,7 +912305,7 @@ }, { "sim":50.0, - "partner":"6t2r" + "partner":"5tgs" }, { "sim":50.0, @@ -908594,12 +912313,16 @@ }, { "sim":50.0, - "partner":"6ubb" + "partner":"6t2r" }, { "sim":50.0, "partner":"6ub8" }, + { + "sim":50.0, + "partner":"6ubb" + }, { "sim":50.0, "partner":"6uba" @@ -908630,11 +912353,11 @@ }, { "sim":50.0, - "partner":"6hxo" + "partner":"6hxn" }, { "sim":50.0, - "partner":"6hxn" + "partner":"6hxo" }, { "sim":50.0, @@ -908642,15 +912365,15 @@ }, { "sim":50.0, - "partner":"2wk1" + "partner":"6ypa" }, { "sim":50.0, - "partner":"6ypa" + "partner":"6akv" }, { "sim":50.0, - "partner":"6akv" + "partner":"2wk1" }, { "sim":50.0, @@ -908658,11 +912381,11 @@ }, { "sim":50.0, - "partner":"4rni" + "partner":"4rnj" }, { "sim":50.0, - "partner":"4rnj" + "partner":"4rni" }, { "sim":50.0, @@ -908728,10 +912451,6 @@ "sim":50.0, "partner":"6cng" }, - { - "sim":50.0, - "partner":"3s3h" - }, { "sim":50.0, "partner":"4gxn" @@ -908756,6 +912475,10 @@ "sim":50.0, "partner":"4gw3" }, + { + "sim":50.0, + "partner":"3s3h" + }, { "sim":50.0, "partner":"3nib" @@ -908776,10 +912499,6 @@ "sim":50.0, "partner":"1g93" }, - { - "sim":50.0, - "partner":"3g3d" - }, { "sim":50.0, "partner":"3bvj" @@ -908796,6 +912515,10 @@ "sim":50.0, "partner":"4hkp" }, + { + "sim":50.0, + "partner":"3g3d" + }, { "sim":50.0, "partner":"5mqv" @@ -908806,23 +912529,23 @@ }, { "sim":50.0, - "partner":"5zmy" + "partner":"6f1w" }, { "sim":50.0, - "partner":"6f1w" + "partner":"5zmy" }, { "sim":50.0, - "partner":"3b3d" + "partner":"7nzy" }, { "sim":50.0, - "partner":"5okt" + "partner":"3b3d" }, { "sim":50.0, - "partner":"7nzy" + "partner":"5okt" }, { "sim":50.0, @@ -908838,19 +912561,19 @@ }, { "sim":50.0, - "partner":"8u05" + "partner":"6l86" }, { "sim":50.0, - "partner":"8u06" + "partner":"8u05" }, { "sim":50.0, - "partner":"8u07" + "partner":"8u06" }, { "sim":50.0, - "partner":"6l86" + "partner":"8u07" }, { "sim":50.0, @@ -908896,10 +912619,6 @@ "sim":50.0, "partner":"5i0k" }, - { - "sim":50.0, - "partner":"3aio" - }, { "sim":50.0, "partner":"3aik" @@ -908920,6 +912639,10 @@ "sim":50.0, "partner":"3ain" }, + { + "sim":50.0, + "partner":"3aio" + }, { "sim":50.0, "partner":"5l84" @@ -908946,19 +912669,19 @@ }, { "sim":50.0, - "partner":"2pzm" + "partner":"2pzk" }, { "sim":50.0, - "partner":"2pzk" + "partner":"2pzl" }, { "sim":50.0, - "partner":"2pzl" + "partner":"2pzm" }, { "sim":50.0, - "partner":"6lcn" + "partner":"7bsx" }, { "sim":50.0, @@ -908966,11 +912689,11 @@ }, { "sim":50.0, - "partner":"7bsx" + "partner":"3h7r" }, { "sim":50.0, - "partner":"3h7r" + "partner":"6lcn" }, { "sim":50.0, @@ -909026,27 +912749,27 @@ }, { "sim":50.0, - "partner":"5tyq" + "partner":"5u0n" }, { "sim":50.0, - "partner":"5u19" + "partner":"5u1e" }, { "sim":50.0, - "partner":"5u0n" + "partner":"5u0t" }, { "sim":50.0, - "partner":"5u1e" + "partner":"5u1i" }, { "sim":50.0, - "partner":"5u0t" + "partner":"5tyq" }, { "sim":50.0, - "partner":"5u1i" + "partner":"5u19" }, { "sim":50.0, @@ -909140,10 +912863,6 @@ "sim":50.0, "partner":"4ot7" }, - { - "sim":50.0, - "partner":"6put" - }, { "sim":50.0, "partner":"6puw" @@ -909158,15 +912877,15 @@ }, { "sim":50.0, - "partner":"5u1c" + "partner":"6puz" }, { "sim":50.0, - "partner":"6puz" + "partner":"5u1c" }, { "sim":50.0, - "partner":"7azd" + "partner":"6put" }, { "sim":50.0, @@ -909198,16 +912917,20 @@ }, { "sim":50.0, - "partner":"5x06" + "partner":"7azg" }, { "sim":50.0, - "partner":"7azg" + "partner":"5x06" }, { "sim":50.0, "partner":"7azc" }, + { + "sim":50.0, + "partner":"7azd" + }, { "sim":50.0, "partner":"6d5a" @@ -909232,10 +912955,6 @@ "sim":50.0, "partner":"2qdg" }, - { - "sim":50.0, - "partner":"4wwv" - }, { "sim":50.0, "partner":"3vvl" @@ -909256,6 +912975,10 @@ "sim":50.0, "partner":"5zzu" }, + { + "sim":50.0, + "partner":"4wwv" + }, { "sim":50.0, "partner":"5gu7" @@ -909284,10 +913007,6 @@ "sim":50.0, "partner":"4y1b" }, - { - "sim":50.0, - "partner":"5cu7" - }, { "sim":50.0, "partner":"4y0k" @@ -909306,7 +913025,7 @@ }, { "sim":50.0, - "partner":"4f6c" + "partner":"5cu7" }, { "sim":50.0, @@ -909320,21 +913039,25 @@ "sim":50.0, "partner":"6hr8" }, + { + "sim":50.0, + "partner":"4f6c" + }, { "sim":50.0, "partner":"8w6z" }, { "sim":50.0, - "partner":"7d88" + "partner":"8w72" }, { "sim":50.0, - "partner":"7d89" + "partner":"7d88" }, { "sim":50.0, - "partner":"8w72" + "partner":"7d89" }, { "sim":50.0, @@ -909348,10 +913071,6 @@ "sim":50.0, "partner":"7u7h" }, - { - "sim":50.0, - "partner":"2imc" - }, { "sim":50.0, "partner":"2ilp" @@ -909382,15 +913101,19 @@ }, { "sim":50.0, - "partner":"7n18" + "partner":"2imc" }, { "sim":50.0, - "partner":"4kuf" + "partner":"8tx8" }, { "sim":50.0, - "partner":"8tx8" + "partner":"7n18" + }, + { + "sim":50.0, + "partner":"4kuf" }, { "sim":50.0, @@ -909440,10 +913163,6 @@ "sim":50.0, "partner":"4rnh" }, - { - "sim":50.0, - "partner":"7tfc" - }, { "sim":50.0, "partner":"7d4k" @@ -909456,6 +913175,10 @@ "sim":50.0, "partner":"7d4n" }, + { + "sim":50.0, + "partner":"7tfc" + }, { "sim":50.0, "partner":"4j1q" @@ -909464,6 +913187,18 @@ "sim":50.0, "partner":"4j1s" }, + { + "sim":50.0, + "partner":"8wn5" + }, + { + "sim":50.0, + "partner":"8wn6" + }, + { + "sim":50.0, + "partner":"8wna" + }, { "sim":50.0, "partner":"8tge" @@ -909484,10 +913219,6 @@ "sim":50.0, "partner":"8ufj" }, - { - "sim":50.0, - "partner":"2wc4" - }, { "sim":50.0, "partner":"1oif" @@ -909602,11 +913333,11 @@ }, { "sim":50.0, - "partner":"6j0u" + "partner":"2wc4" }, { "sim":50.0, - "partner":"6ak4" + "partner":"6j0u" }, { "sim":50.0, @@ -909628,6 +913359,10 @@ "sim":50.0, "partner":"6llb" }, + { + "sim":50.0, + "partner":"6ak4" + }, { "sim":50.0, "partner":"8u41" @@ -909650,11 +913385,11 @@ }, { "sim":50.0, - "partner":"4dqv" + "partner":"4u5q" }, { "sim":50.0, - "partner":"4u5q" + "partner":"4dqv" }, { "sim":50.0, @@ -909692,10 +913427,6 @@ "sim":50.0, "partner":"6jzs" }, - { - "sim":50.0, - "partner":"4ie7" - }, { "sim":50.0, "partner":"4cxw" @@ -909714,15 +913445,15 @@ }, { "sim":50.0, - "partner":"4idz" + "partner":"7e8z" }, { "sim":50.0, - "partner":"4ie0" + "partner":"4idz" }, { "sim":50.0, - "partner":"7e8z" + "partner":"4ie0" }, { "sim":50.0, @@ -909740,6 +913471,10 @@ "sim":50.0, "partner":"4qho" }, + { + "sim":50.0, + "partner":"4ie7" + }, { "sim":50.0, "partner":"6u4z" @@ -909760,25 +913495,17 @@ "sim":50.0, "partner":"7wh9" }, - { - "sim":50.0, - "partner":"8w04" - }, { "sim":50.0, "partner":"8w01" }, { "sim":50.0, - "partner":"3n6r" - }, - { - "sim":50.0, - "partner":"8aq3" + "partner":"8w04" }, { "sim":50.0, - "partner":"8aq4" + "partner":"3n6r" }, { "sim":50.0, @@ -909788,10 +913515,6 @@ "sim":50.0, "partner":"8b0k" }, - { - "sim":50.0, - "partner":"5n6h" - }, { "sim":50.0, "partner":"8b0l" @@ -909804,6 +913527,10 @@ "sim":50.0, "partner":"8b0n" }, + { + "sim":50.0, + "partner":"5n6h" + }, { "sim":50.0, "partner":"8b0o" @@ -909822,12 +913549,20 @@ }, { "sim":50.0, - "partner":"8j8h" + "partner":"8aq3" + }, + { + "sim":50.0, + "partner":"8aq4" }, { "sim":50.0, "partner":"8j9g" }, + { + "sim":50.0, + "partner":"8j8h" + }, { "sim":50.0, "partner":"7wh1" @@ -909874,7 +913609,7 @@ }, { "sim":50.0, - "partner":"5m12" + "partner":"6gwg" }, { "sim":50.0, @@ -909882,20 +913617,12 @@ }, { "sim":50.0, - "partner":"6gwf" - }, - { - "sim":50.0, - "partner":"6gwg" + "partner":"6gta" }, { "sim":50.0, "partner":"5m16" }, - { - "sim":50.0, - "partner":"6gta" - }, { "sim":50.0, "partner":"6gvd" @@ -909910,11 +913637,15 @@ }, { "sim":50.0, - "partner":"6j1f" + "partner":"5m12" }, { "sim":50.0, - "partner":"6j1e" + "partner":"6gwf" + }, + { + "sim":50.0, + "partner":"6j1f" }, { "sim":50.0, @@ -909932,6 +913663,10 @@ "sim":50.0, "partner":"6j0p" }, + { + "sim":50.0, + "partner":"6j1e" + }, { "sim":50.0, "partner":"3i3l" @@ -909972,10 +913707,6 @@ "sim":50.0, "partner":"3vsn" }, - { - "sim":50.0, - "partner":"7w1c" - }, { "sim":50.0, "partner":"7w1d" @@ -909986,15 +913717,7 @@ }, { "sim":50.0, - "partner":"2yii" - }, - { - "sim":50.0, - "partner":"4c5s" - }, - { - "sim":50.0, - "partner":"4v2r" + "partner":"7w1c" }, { "sim":50.0, @@ -910020,22 +913743,30 @@ "sim":50.0, "partner":"4c5r" }, + { + "sim":50.0, + "partner":"2yii" + }, { "sim":50.0, "partner":"4v2q" }, { "sim":50.0, - "partner":"5uw0" + "partner":"4c5s" }, { "sim":50.0, - "partner":"5vnc" + "partner":"4v2r" }, { "sim":50.0, "partner":"5uw1" }, + { + "sim":50.0, + "partner":"5vnc" + }, { "sim":50.0, "partner":"5uw4" @@ -910046,7 +913777,7 @@ }, { "sim":50.0, - "partner":"3rsz" + "partner":"5uw0" }, { "sim":50.0, @@ -910076,6 +913807,10 @@ "sim":50.0, "partner":"3nch" }, + { + "sim":50.0, + "partner":"3rsz" + }, { "sim":50.0, "partner":"8eax" @@ -910096,10 +913831,6 @@ "sim":50.0, "partner":"2wco" }, - { - "sim":50.0, - "partner":"6edw" - }, { "sim":50.0, "partner":"6edz" @@ -910110,15 +913841,11 @@ }, { "sim":50.0, - "partner":"8bou" - }, - { - "sim":50.0, - "partner":"4j3t" + "partner":"6edw" }, { "sim":50.0, - "partner":"4j3u" + "partner":"8bou" }, { "sim":50.0, @@ -910138,7 +913865,11 @@ }, { "sim":50.0, - "partner":"5y1h" + "partner":"4j3t" + }, + { + "sim":50.0, + "partner":"4j3u" }, { "sim":50.0, @@ -910184,6 +913915,10 @@ "sim":50.0, "partner":"5y3i" }, + { + "sim":50.0, + "partner":"5y1h" + }, { "sim":50.0, "partner":"7s6b" @@ -910202,15 +913937,15 @@ }, { "sim":50.0, - "partner":"7o3m" + "partner":"7o3n" }, { "sim":50.0, - "partner":"7o3n" + "partner":"7o3l" }, { "sim":50.0, - "partner":"7o3l" + "partner":"7o3m" }, { "sim":50.0, @@ -910430,112 +914165,112 @@ ], "subtitle":"Computational designed nanocage o43_129", "tags":[ - "o43_129", - "extendable nanomaterials", + "de novo", "de novo protein", - "nanocage", - "de novo" + "extendable nanomaterials", + "o43_129", + "nanocage" ], "keywords":[ "largely", - "oligomers", - "many", + "regularity", + "specified", + "number", + "owing", + "well", + "nested", + "wooden", + "protein", + "readily", + "linear", + "electron", + "blueprinted", + "microscopy", + "straightforward", + "house", + "circular", + "multicomponent", + "standards", + "secondary", + "envelope", + "using", + "placement", + "geometric", + "construction", + "complex", + "enables", "conform", - "inherit", + "backbones", + "comparison", + "enabling", + "polygonal", + "surfaces", + "track", + "blocks", "modules", - "crystallography", - "extendable", - "designed", - "geometries", - "deliberate", - "curved", + "large", "shapes", - "envelope", - "irregular", - "geometric", + "deliberate", + "pieces", + "1", + "geometries", + "consists", "blueprints", - "interactions", - "validate", - "structure", - "owing", - "building", + "design", + "onto", "principles", - "backbones", - "interaction", - "extendability", - "enables", - "straightforward", - "house", - "linear", - "angled", - "number", - "simple", + "expanded", + "simplicity", "geometrical", - "wooden", - "concentrically", - "relationships", - "onto", - "structures", - "nanomaterial", - "complexity", - "pieces", - "polygonal", - "circular", - "unbounded", - "much", + "simple", + "possible", + "different", + "sizes", "platform", - "previously", + "straight", + "architectural", "nanocages", - "polyhedral", - "regularity", - "specified", - "large", - "nested", + "complexity", + "relationships", + "build", + "validate", + "extendability", + "lumber", + "interaction", + "varying", + "nanomaterials", + "building", + "describe", "assemblies", + "designed", + "reinforced", + "concentrically", + "contracted", + "nanomaterial", + "curved", + "many", + "unbounded", + "structures", "ranging", - "1", - "lumber", - "surfaces", + "reconfigurable", + "polyhedral", + "oligomers", + "previously", + "structure", + "extendable", + "frame", "according", - "straight", + "irregular", + "crystallography", + "interactions", + "angled", + "regular", "blank", - "blocks", - "comparison", - "design", + "much", "canvas", - "using", - "secondary", - "describe", - "nanomaterials", - "architectural", - "reinforced", - "enabling", - "multicomponent", + "struts", "designs", - "build", - "construction", - "track", - "placement", - "sizes", - "electron", - "well", - "different", - "contracted", - "protein", - "regular", - "microscopy", - "frame", - "standards", - "complex", - "reconfigurable", - "readily", - "blueprinted", - "varying", - "consists", - "simplicity", - "possible", - "expanded", - "struts" + "inherit" ], "release_date":"2024-03-13", "publication":"\"Blueprinting extendable nanomaterials with standardized protein blocks\", Nature, 627, 898-904", @@ -910570,6 +914305,18 @@ "sim":571.0, "partner":"8v3b" }, + { + "sim":83.0, + "partner":"8ure" + }, + { + "sim":61.0, + "partner":"7ue2" + }, + { + "sim":54.0, + "partner":"8f6r" + }, { "sim":239.0, "partner":"8e0l" @@ -910632,11 +914379,11 @@ }, { "sim":52.0, - "partner":"7udm" + "partner":"7udn" }, { "sim":52.0, - "partner":"7udn" + "partner":"7udm" }, { "sim":51.0, @@ -910649,18 +914396,6 @@ { "sim":50.0, "partner":"8evm" - }, - { - "sim":83.0, - "partner":"8ure" - }, - { - "sim":61.0, - "partner":"7ue2" - }, - { - "sim":54.0, - "partner":"8f6r" } ], "seq_thr_sim_natural":[ @@ -910743,123 +914478,123 @@ ], "subtitle":"Crystal structure of the ancestral triosephosphate isomerase reconstruction of the last opisthokont common ancestor obtained by bayesian inference", "tags":[ - "triose phosphate isomerase", + "isomerase", "ancestral sequence reconstruction", - "isomerase" + "triose phosphate isomerase" ], "keywords":[ - "work", - "tims", - "analysis", - "evolution", - "unfolding", - "lineages", - "evidence", - "oligomers", - "monomeric", - "located", - "part", - "bonds", - "conserved", - "test", - "isomerase", - "physicochemical", "opisthokonts", - "protozoan", - "reconstruction", - "sequences", - "robustness", - "equilibrium", - "structure", - "monomer", - "applied", - "oligomer", - "resembles", - "unstable", - "spectroscopic", + "tot", + "hydrodynamic", + "well", + "opisthokonta", + "presence", + "differences", + "bottom", + "locatims", "locatim", - "structured", - "reversible", - "resembling", - "reached", - "similar", - "infer", - "obligated", - "calorimetric", + "unstable", + "parameters", + "resembles", + "physicochemical", + "study", "indicated", - "although", - "strongly", - "locatims", - "presence", - "used", - "ancestral", - "comparative", - "structures", - "transitions", - "function", + "unfolding", "showed", - "triosephosphate", - "intermediates", + "equilibrium", "extensive", + "test", + "catalytic", + "two", + "infer", + "lineages", + "similar", + "worst", + "reconstructed", "shows", - "coupled", + "conformational", + "isomerase", + "ones", + "intermediates", + "although", + "last", + "case", + "strongly", + "triosephosphate", + "stability", + "part", + "evidence", + "characterization", + "several", + "ancestral", "hydrogen", "inference", - "properties", - "previously", - "stability", - "monomers", - "bottom", + "found", + "reached", + "\u03b4g", + "resembling", + "evolution", "higher", - "common", - "worst", - "methodologies", - "catalytic", - "temperature", - "four", - "unf", "diverged", - "observed", - "several", - "melting", - "characterization", - "confidence", - "rather", - "\u03b4g", - "high", - "sequence", - "parameters", + "robustness", + "four", + "monomer", + "barrel", + "correlation", "increase", + "spectroscopic", + "calorimetric", + "work", + "used", "extant", - "notably", - "ancestor", - "ones", - "tim", - "hydrodynamic", + "different", + "transitions", + "monomers", + "properties", + "bonds", + "also", + "reversible", + "confidence", + "inactive", + "methodologies", + "oligomer", + "unf", "plausible", + "notably", + "sequence", + "applied", + "common", "3d", - "opisthokonta", - "conformational", - "estimated", - "also", - "study", + "analysis", + "coupled", + "sequences", + "comparative", + "conserved", + "rather", + "observed", + "structures", + "reconstruction", + "oligomers", + "previously", + "structured", + "structure", + "monomeric", "fungi", - "barrel", - "tot", - "well", - "last", - "different", - "found", - "two", - "reconstructed", - "inactive", + "scenario", + "temperature", + "biophysical", + "function", + "melting", + "obligated", "energetics", + "located", + "high", + "estimated", + "tim", + "tims", + "ancestor", "animals", - "differences", - "scenario", - "case", - "correlation", - "biophysical" + "protozoan" ], "release_date":"2024-09-04", "publication":"\"Stable monomers in the ancestral sequence reconstruction of the last opisthokont common ancestor of dimeric triosephosphate isomerase\", Protein Sci., 33, e5134-e5134", @@ -910900,19 +914635,19 @@ }, { "sim":499.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":499.0, - "partner":"8w05" + "partner":"8w06" }, { "sim":490.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":490.0, - "partner":"8w08" + "partner":"8v0a" }, { "sim":53.0, @@ -910924,11 +914659,11 @@ }, { "sim":50.0, - "partner":"8jpa" + "partner":"8hdv" }, { "sim":50.0, - "partner":"8hdv" + "partner":"8jpa" }, { "sim":50.0, @@ -911042,11 +914777,11 @@ }, { "sim":343.0, - "partner":"8tim" + "partner":"1tph" }, { "sim":343.0, - "partner":"1tph" + "partner":"8tim" }, { "sim":343.0, @@ -911078,19 +914813,19 @@ }, { "sim":342.0, - "partner":"1r2s" + "partner":"4owg" }, { "sim":342.0, - "partner":"1r2t" + "partner":"1r2r" }, { "sim":342.0, - "partner":"4owg" + "partner":"1r2s" }, { "sim":342.0, - "partner":"1r2r" + "partner":"1r2t" }, { "sim":342.0, @@ -911210,15 +914945,15 @@ }, { "sim":314.0, - "partner":"8j7c" + "partner":"4gnj" }, { "sim":314.0, - "partner":"8jbp" + "partner":"8j7c" }, { "sim":314.0, - "partner":"4gnj" + "partner":"8jbp" }, { "sim":308.0, @@ -911230,15 +914965,15 @@ }, { "sim":303.0, - "partner":"2ypi" + "partner":"1ypi" }, { "sim":303.0, - "partner":"1ypi" + "partner":"7tim" }, { "sim":303.0, - "partner":"7tim" + "partner":"2ypi" }, { "sim":301.0, @@ -911254,11 +914989,11 @@ }, { "sim":295.0, - "partner":"1nf0" + "partner":"1ney" }, { "sim":295.0, - "partner":"1ney" + "partner":"1nf0" }, { "sim":287.0, @@ -911276,18 +915011,6 @@ "sim":284.0, "partner":"3qsr" }, - { - "sim":282.0, - "partner":"7az3" - }, - { - "sim":282.0, - "partner":"2vxn" - }, - { - "sim":282.0, - "partner":"7az4" - }, { "sim":282.0, "partner":"1n55" @@ -911314,16 +915037,28 @@ }, { "sim":282.0, - "partner":"1if2" + "partner":"7abx" }, { "sim":282.0, - "partner":"7abx" + "partner":"7az3" }, { "sim":282.0, "partner":"1qds" }, + { + "sim":282.0, + "partner":"7az4" + }, + { + "sim":282.0, + "partner":"1if2" + }, + { + "sim":282.0, + "partner":"2vxn" + }, { "sim":281.0, "partner":"4o4v" @@ -911350,15 +915085,15 @@ }, { "sim":279.0, - "partner":"4o50" + "partner":"4o54" }, { "sim":279.0, - "partner":"4o54" + "partner":"4o57" }, { "sim":279.0, - "partner":"4o57" + "partner":"4o50" }, { "sim":279.0, @@ -911412,10 +915147,6 @@ "sim":271.0, "partner":"1iig" }, - { - "sim":271.0, - "partner":"2v0t" - }, { "sim":271.0, "partner":"1iih" @@ -911446,15 +915177,19 @@ }, { "sim":271.0, - "partner":"4tim" + "partner":"2v0t" }, { "sim":271.0, - "partner":"2v5l" + "partner":"6tim" }, { "sim":271.0, - "partner":"6tim" + "partner":"4tim" + }, + { + "sim":271.0, + "partner":"2v5l" }, { "sim":270.0, @@ -911490,7 +915225,7 @@ }, { "sim":268.0, - "partner":"1kv5" + "partner":"5i3f" }, { "sim":268.0, @@ -911498,7 +915233,7 @@ }, { "sim":268.0, - "partner":"5i3f" + "partner":"1kv5" }, { "sim":266.0, @@ -911570,19 +915305,15 @@ }, { "sim":245.0, - "partner":"2vfd" + "partner":"4ywi" }, { "sim":245.0, - "partner":"2vfe" + "partner":"2vfd" }, { "sim":245.0, - "partner":"4ywi" - }, - { - "sim":244.0, - "partner":"1lzo" + "partner":"2vfe" }, { "sim":244.0, @@ -911618,15 +915349,11 @@ }, { "sim":244.0, - "partner":"1m7p" - }, - { - "sim":243.0, - "partner":"5gv4" + "partner":"1lzo" }, { - "sim":243.0, - "partner":"5gzp" + "sim":244.0, + "partner":"1m7p" }, { "sim":243.0, @@ -911652,6 +915379,14 @@ "sim":243.0, "partner":"5brb" }, + { + "sim":243.0, + "partner":"5gzp" + }, + { + "sim":243.0, + "partner":"5gv4" + }, { "sim":242.0, "partner":"2v2d" @@ -911776,10 +915511,6 @@ "sim":227.0, "partner":"4pc8" }, - { - "sim":222.0, - "partner":"3uwz" - }, { "sim":222.0, "partner":"3uwu" @@ -911796,17 +915527,21 @@ "sim":222.0, "partner":"3uwy" }, + { + "sim":222.0, + "partner":"3uwz" + }, { "sim":220.0, "partner":"7rpn" }, { "sim":216.0, - "partner":"4iot" + "partner":"1tre" }, { "sim":216.0, - "partner":"1tre" + "partner":"4iot" }, { "sim":213.0, @@ -911976,10 +915711,6 @@ "sim":57.0, "partner":"6njq" }, - { - "sim":57.0, - "partner":"5mit" - }, { "sim":57.0, "partner":"5mjk" @@ -912006,7 +915737,7 @@ }, { "sim":57.0, - "partner":"2cj9" + "partner":"5mit" }, { "sim":57.0, @@ -912021,44 +915752,44 @@ "partner":"2cjb" }, { - "sim":56.0, - "partner":"5y0f" + "sim":57.0, + "partner":"2cj9" }, { "sim":56.0, - "partner":"5y0g" + "partner":"4nns" }, { "sim":56.0, - "partner":"4nns" + "partner":"4nnt" }, { "sim":56.0, - "partner":"4nnt" + "partner":"6ljs" }, { "sim":56.0, - "partner":"5y12" + "partner":"6ljt" }, { "sim":56.0, - "partner":"6ljs" + "partner":"8wdx" }, { "sim":56.0, - "partner":"5d45" + "partner":"5y12" }, { "sim":56.0, - "partner":"5y13" + "partner":"6lju" }, { "sim":56.0, - "partner":"6ljt" + "partner":"5d45" }, { "sim":56.0, - "partner":"6lju" + "partner":"5y13" }, { "sim":56.0, @@ -912082,7 +915813,7 @@ }, { "sim":56.0, - "partner":"8wdx" + "partner":"8we3" }, { "sim":56.0, @@ -912094,11 +915825,15 @@ }, { "sim":56.0, - "partner":"8we3" + "partner":"5y0x" }, { "sim":56.0, - "partner":"5y0x" + "partner":"5y0f" + }, + { + "sim":56.0, + "partner":"5y0g" }, { "sim":56.0, @@ -912322,15 +916057,15 @@ }, { "sim":54.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":54.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":54.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":54.0, @@ -912378,15 +916113,15 @@ }, { "sim":54.0, - "partner":"8wov" + "partner":"8wop" }, { "sim":54.0, - "partner":"8wow" + "partner":"8wov" }, { "sim":54.0, - "partner":"8wop" + "partner":"8wow" }, { "sim":54.0, @@ -912510,15 +916245,15 @@ }, { "sim":53.0, - "partner":"3th5" + "partner":"4gzl" }, { "sim":53.0, - "partner":"4gzl" + "partner":"4gzm" }, { "sim":53.0, - "partner":"4gzm" + "partner":"3th5" }, { "sim":53.0, @@ -912532,10 +916267,6 @@ "sim":53.0, "partner":"3ofv" }, - { - "sim":53.0, - "partner":"6ueo" - }, { "sim":53.0, "partner":"6uep" @@ -912550,11 +916281,11 @@ }, { "sim":53.0, - "partner":"3l4c" + "partner":"6ueo" }, { "sim":53.0, - "partner":"6j0l" + "partner":"3l4c" }, { "sim":53.0, @@ -912566,19 +916297,19 @@ }, { "sim":53.0, - "partner":"1ku1" + "partner":"6j0l" }, { "sim":53.0, - "partner":"7o2t" + "partner":"1ku1" }, { "sim":53.0, - "partner":"7o2u" + "partner":"6z17" }, { "sim":53.0, - "partner":"6z17" + "partner":"7o2u" }, { "sim":53.0, @@ -912596,6 +916327,10 @@ "sim":53.0, "partner":"6z5k" }, + { + "sim":53.0, + "partner":"7o2t" + }, { "sim":53.0, "partner":"2brx" @@ -912622,23 +916357,23 @@ }, { "sim":53.0, - "partner":"6ihr" + "partner":"6ihv" }, { "sim":53.0, - "partner":"6iht" + "partner":"6ihw" }, { "sim":53.0, - "partner":"6ihu" + "partner":"6ihr" }, { "sim":53.0, - "partner":"6ihv" + "partner":"6iht" }, { "sim":53.0, - "partner":"6ihw" + "partner":"6ihu" }, { "sim":53.0, @@ -912690,11 +916425,11 @@ }, { "sim":53.0, - "partner":"3la8" + "partner":"3lba" }, { "sim":53.0, - "partner":"3lba" + "partner":"3la8" }, { "sim":53.0, @@ -912766,15 +916501,15 @@ }, { "sim":53.0, - "partner":"7mdl" + "partner":"8g9z" }, { "sim":53.0, - "partner":"8g9z" + "partner":"7l1t" }, { "sim":53.0, - "partner":"7l1t" + "partner":"7mdl" }, { "sim":53.0, @@ -912782,11 +916517,11 @@ }, { "sim":53.0, - "partner":"2vbg" + "partner":"2vbf" }, { "sim":53.0, - "partner":"2vbf" + "partner":"2vbg" }, { "sim":53.0, @@ -912822,16 +916557,12 @@ }, { "sim":53.0, - "partner":"5uw0" + "partner":"5uw1" }, { "sim":53.0, "partner":"5vnc" }, - { - "sim":53.0, - "partner":"5uw1" - }, { "sim":53.0, "partner":"5uw4" @@ -912842,7 +916573,7 @@ }, { "sim":53.0, - "partner":"3rsz" + "partner":"5uw0" }, { "sim":53.0, @@ -912872,6 +916603,10 @@ "sim":53.0, "partner":"3nch" }, + { + "sim":53.0, + "partner":"3rsz" + }, { "sim":53.0, "partner":"3slk" @@ -912908,10 +916643,6 @@ "sim":52.0, "partner":"1w6v" }, - { - "sim":52.0, - "partner":"5zrk" - }, { "sim":52.0, "partner":"5zrl" @@ -912940,6 +916671,10 @@ "sim":52.0, "partner":"5zri" }, + { + "sim":52.0, + "partner":"5zrk" + }, { "sim":52.0, "partner":"3oq0" @@ -912958,11 +916693,11 @@ }, { "sim":52.0, - "partner":"1x24" + "partner":"1zcl" }, { "sim":52.0, - "partner":"1zcl" + "partner":"1x24" }, { "sim":52.0, @@ -912994,11 +916729,11 @@ }, { "sim":52.0, - "partner":"3oci" + "partner":"3oc3" }, { "sim":52.0, - "partner":"3oc3" + "partner":"3oci" }, { "sim":52.0, @@ -913010,27 +916745,27 @@ }, { "sim":52.0, - "partner":"4bmx" + "partner":"4bmz" }, { "sim":52.0, - "partner":"4bmy" + "partner":"4bn0" }, { "sim":52.0, - "partner":"4bmz" + "partner":"4bmx" }, { "sim":52.0, - "partner":"4bn0" + "partner":"4bmy" }, { "sim":52.0, - "partner":"5h5a" + "partner":"5h54" }, { "sim":52.0, - "partner":"5h54" + "partner":"5h5a" }, { "sim":52.0, @@ -913078,23 +916813,23 @@ }, { "sim":52.0, - "partner":"6mql" + "partner":"6mqb" }, { "sim":52.0, - "partner":"6mq9" + "partner":"6mqk" }, { "sim":52.0, - "partner":"6mqb" + "partner":"1xse" }, { "sim":52.0, - "partner":"1xse" + "partner":"6mql" }, { "sim":52.0, - "partner":"6mqk" + "partner":"6mq9" }, { "sim":52.0, @@ -913130,15 +916865,15 @@ }, { "sim":52.0, - "partner":"4w7v" + "partner":"4w7u" }, { "sim":52.0, - "partner":"4w7w" + "partner":"4w7v" }, { "sim":52.0, - "partner":"4w7u" + "partner":"4w7w" }, { "sim":52.0, @@ -913150,11 +916885,11 @@ }, { "sim":52.0, - "partner":"7js3" + "partner":"8g5w" }, { "sim":52.0, - "partner":"8g5w" + "partner":"7js3" }, { "sim":52.0, @@ -913192,10 +916927,6 @@ "sim":52.0, "partner":"4rhq" }, - { - "sim":52.0, - "partner":"5g6t" - }, { "sim":52.0, "partner":"5g5u" @@ -913224,6 +916955,10 @@ "sim":52.0, "partner":"5g5k" }, + { + "sim":52.0, + "partner":"5g6t" + }, { "sim":52.0, "partner":"3kzm" @@ -913276,22 +917011,6 @@ "sim":52.0, "partner":"3kzk" }, - { - "sim":52.0, - "partner":"7wxl" - }, - { - "sim":52.0, - "partner":"7wxm" - }, - { - "sim":52.0, - "partner":"7wxn" - }, - { - "sim":52.0, - "partner":"7wxo" - }, { "sim":52.0, "partner":"7wxp" @@ -913322,7 +917041,19 @@ }, { "sim":52.0, - "partner":"5hxu" + "partner":"7wxl" + }, + { + "sim":52.0, + "partner":"7wxm" + }, + { + "sim":52.0, + "partner":"7wxn" + }, + { + "sim":52.0, + "partner":"7wxo" }, { "sim":52.0, @@ -913336,6 +917067,10 @@ "sim":52.0, "partner":"5hwe" }, + { + "sim":52.0, + "partner":"5hxu" + }, { "sim":52.0, "partner":"4r9v" @@ -913406,51 +917141,51 @@ }, { "sim":52.0, - "partner":"4gyk" + "partner":"4gyj" }, { "sim":52.0, - "partner":"4gyj" + "partner":"4gyk" }, { "sim":52.0, - "partner":"2yii" + "partner":"4c5u" }, { "sim":52.0, - "partner":"4c5s" + "partner":"4cq5" }, { "sim":52.0, - "partner":"4v2r" + "partner":"4baa" }, { "sim":52.0, - "partner":"4c5u" + "partner":"4c6g" }, { "sim":52.0, - "partner":"4cq5" + "partner":"4bab" }, { "sim":52.0, - "partner":"4baa" + "partner":"4c5r" }, { "sim":52.0, - "partner":"4c6g" + "partner":"2yii" }, { "sim":52.0, - "partner":"4bab" + "partner":"4v2q" }, { "sim":52.0, - "partner":"4c5r" + "partner":"4c5s" }, { "sim":52.0, - "partner":"4v2q" + "partner":"4v2r" }, { "sim":52.0, @@ -913512,10 +917247,6 @@ "sim":51.0, "partner":"3ctg" }, - { - "sim":51.0, - "partner":"4hmr" - }, { "sim":51.0, "partner":"4hls" @@ -913528,6 +917259,10 @@ "sim":51.0, "partner":"1yx3" }, + { + "sim":51.0, + "partner":"4hmr" + }, { "sim":51.0, "partner":"2lea" @@ -913648,10 +917383,6 @@ "sim":51.0, "partner":"6gum" }, - { - "sim":51.0, - "partner":"3l1u" - }, { "sim":51.0, "partner":"3l1v" @@ -913668,6 +917399,10 @@ "sim":51.0, "partner":"3esr" }, + { + "sim":51.0, + "partner":"3l1u" + }, { "sim":51.0, "partner":"4kce" @@ -913816,14 +917551,6 @@ "sim":51.0, "partner":"5vrc" }, - { - "sim":51.0, - "partner":"3quo" - }, - { - "sim":51.0, - "partner":"3qvf" - }, { "sim":51.0, "partner":"3qur" @@ -913854,7 +917581,11 @@ }, { "sim":51.0, - "partner":"4rdh" + "partner":"3quo" + }, + { + "sim":51.0, + "partner":"3qvf" }, { "sim":51.0, @@ -913866,19 +917597,19 @@ }, { "sim":51.0, - "partner":"5bwl" + "partner":"4rdh" }, { "sim":51.0, - "partner":"6m09" + "partner":"5bwl" }, { "sim":51.0, - "partner":"6m0a" + "partner":"6m09" }, { "sim":51.0, - "partner":"6wye" + "partner":"6m0a" }, { "sim":51.0, @@ -913892,6 +917623,10 @@ "sim":51.0, "partner":"4ats" }, + { + "sim":51.0, + "partner":"6wye" + }, { "sim":51.0, "partner":"7umj" @@ -913926,11 +917661,11 @@ }, { "sim":51.0, - "partner":"6aa8" + "partner":"7eov" }, { "sim":51.0, - "partner":"7eov" + "partner":"6aa8" }, { "sim":51.0, @@ -913940,10 +917675,6 @@ "sim":51.0, "partner":"5dz7" }, - { - "sim":51.0, - "partner":"8wlb" - }, { "sim":51.0, "partner":"8wl5" @@ -913958,19 +917689,19 @@ }, { "sim":51.0, - "partner":"3zgc" + "partner":"8wlb" }, { "sim":51.0, - "partner":"3zgd" + "partner":"3zgc" }, { "sim":51.0, - "partner":"6toe" + "partner":"3zgd" }, { "sim":51.0, - "partner":"3g3d" + "partner":"6toe" }, { "sim":51.0, @@ -913990,51 +917721,55 @@ }, { "sim":51.0, - "partner":"7q2b" + "partner":"3g3d" }, { "sim":51.0, - "partner":"3ha3" + "partner":"7q2f" }, { "sim":51.0, - "partner":"7q2c" + "partner":"7q2g" }, { "sim":51.0, - "partner":"7q2d" + "partner":"7q2h" }, { "sim":51.0, - "partner":"7q2e" + "partner":"3ha5" }, { "sim":51.0, - "partner":"7q2f" + "partner":"2fk7" }, { "sim":51.0, - "partner":"7q2g" + "partner":"2fk8" }, { "sim":51.0, - "partner":"7q2h" + "partner":"3ha7" }, { "sim":51.0, - "partner":"3ha5" + "partner":"7q2b" }, { "sim":51.0, - "partner":"2fk7" + "partner":"7q2c" }, { "sim":51.0, - "partner":"2fk8" + "partner":"3ha3" }, { "sim":51.0, - "partner":"3ha7" + "partner":"7q2d" + }, + { + "sim":51.0, + "partner":"7q2e" }, { "sim":51.0, @@ -914176,14 +917911,6 @@ "sim":51.0, "partner":"4ig7" }, - { - "sim":51.0, - "partner":"4fif" - }, - { - "sim":51.0, - "partner":"7s46" - }, { "sim":51.0, "partner":"4fig" @@ -914234,7 +917961,11 @@ }, { "sim":51.0, - "partner":"6sf5" + "partner":"4fif" + }, + { + "sim":51.0, + "partner":"7s46" }, { "sim":51.0, @@ -914242,11 +917973,11 @@ }, { "sim":51.0, - "partner":"3ren" + "partner":"6sf5" }, { "sim":51.0, - "partner":"5l9l" + "partner":"3ren" }, { "sim":51.0, @@ -914268,6 +917999,10 @@ "sim":51.0, "partner":"5l9i" }, + { + "sim":51.0, + "partner":"5l9l" + }, { "sim":51.0, "partner":"5xm6" @@ -914284,10 +918019,6 @@ "sim":51.0, "partner":"5v8y" }, - { - "sim":51.0, - "partner":"5jyf" - }, { "sim":51.0, "partner":"5v8x" @@ -914316,6 +918047,10 @@ "sim":51.0, "partner":"5jye" }, + { + "sim":51.0, + "partner":"5jyf" + }, { "sim":51.0, "partner":"6nxc" @@ -914340,10 +918075,6 @@ "sim":51.0, "partner":"3txx" }, - { - "sim":51.0, - "partner":"8hmn" - }, { "sim":51.0, "partner":"7o9o" @@ -914354,15 +918085,15 @@ }, { "sim":51.0, - "partner":"8tne" + "partner":"8hmn" }, { "sim":51.0, - "partner":"7us5" + "partner":"8tne" }, { "sim":51.0, - "partner":"4m1i" + "partner":"7us5" }, { "sim":51.0, @@ -914376,6 +918107,10 @@ "sim":51.0, "partner":"4m1h" }, + { + "sim":51.0, + "partner":"4m1i" + }, { "sim":51.0, "partner":"4o6e" @@ -914392,10 +918127,6 @@ "sim":51.0, "partner":"3wnd" }, - { - "sim":51.0, - "partner":"3c1y" - }, { "sim":51.0, "partner":"3c1z" @@ -914422,7 +918153,7 @@ }, { "sim":51.0, - "partner":"4zhs" + "partner":"3c1y" }, { "sim":51.0, @@ -914430,19 +918161,19 @@ }, { "sim":51.0, - "partner":"4ltz" + "partner":"4zhs" }, { "sim":51.0, - "partner":"7kj8" + "partner":"3kbk" }, { "sim":51.0, - "partner":"7kj9" + "partner":"6ax9" }, { "sim":51.0, - "partner":"3kbk" + "partner":"7kjd" }, { "sim":51.0, @@ -914450,7 +918181,7 @@ }, { "sim":51.0, - "partner":"6ax9" + "partner":"7kje" }, { "sim":51.0, @@ -914458,39 +918189,31 @@ }, { "sim":51.0, - "partner":"8su2" - }, - { - "sim":51.0, - "partner":"8su3" - }, - { - "sim":51.0, - "partner":"7kjd" + "partner":"6axu" }, { "sim":51.0, - "partner":"8su4" + "partner":"7kjf" }, { "sim":51.0, - "partner":"6axu" + "partner":"8su2" }, { "sim":51.0, - "partner":"7kje" + "partner":"7kjg" }, { "sim":51.0, - "partner":"8su5" + "partner":"8su3" }, { "sim":51.0, - "partner":"7kjf" + "partner":"8v3k" }, { "sim":51.0, - "partner":"7kjg" + "partner":"8su4" }, { "sim":51.0, @@ -914498,11 +918221,11 @@ }, { "sim":51.0, - "partner":"3kb9" + "partner":"8su5" }, { "sim":51.0, - "partner":"8v3k" + "partner":"3kb9" }, { "sim":51.0, @@ -914542,7 +918265,15 @@ }, { "sim":51.0, - "partner":"3pz9" + "partner":"7kj8" + }, + { + "sim":51.0, + "partner":"4ltz" + }, + { + "sim":51.0, + "partner":"7kj9" }, { "sim":51.0, @@ -914568,6 +918299,10 @@ "sim":51.0, "partner":"3pzq" }, + { + "sim":51.0, + "partner":"3pz9" + }, { "sim":51.0, "partner":"3dkb" @@ -914594,11 +918329,11 @@ }, { "sim":51.0, - "partner":"2gqn" + "partner":"2fq6" }, { "sim":51.0, - "partner":"2fq6" + "partner":"2gqn" }, { "sim":51.0, @@ -914606,31 +918341,31 @@ }, { "sim":51.0, - "partner":"4euh" + "partner":"4eue" }, { "sim":51.0, - "partner":"4eue" + "partner":"4euf" }, { "sim":51.0, - "partner":"4euf" + "partner":"4euh" }, { "sim":51.0, - "partner":"5dvi" + "partner":"5dvj" }, { "sim":51.0, - "partner":"3l5a" + "partner":"5dvf" }, { "sim":51.0, - "partner":"5dvj" + "partner":"5dvi" }, { "sim":51.0, - "partner":"5dvf" + "partner":"3l5a" }, { "sim":51.0, @@ -914672,10 +918407,6 @@ "sim":51.0, "partner":"7ui4" }, - { - "sim":51.0, - "partner":"4q6q" - }, { "sim":51.0, "partner":"4q6m" @@ -914694,19 +918425,19 @@ }, { "sim":51.0, - "partner":"6v99" + "partner":"4q6q" }, { "sim":51.0, - "partner":"6v9a" + "partner":"6v96" }, { "sim":51.0, - "partner":"6v96" + "partner":"6v99" }, { "sim":51.0, - "partner":"2imc" + "partner":"6v9a" }, { "sim":51.0, @@ -914732,6 +918463,10 @@ "sim":51.0, "partner":"2imb" }, + { + "sim":51.0, + "partner":"2imc" + }, { "sim":51.0, "partner":"7n18" @@ -914760,10 +918495,6 @@ "sim":51.0, "partner":"4elc" }, - { - "sim":51.0, - "partner":"7lr2" - }, { "sim":51.0, "partner":"7lr6" @@ -914776,6 +918507,10 @@ "sim":51.0, "partner":"5xwb" }, + { + "sim":51.0, + "partner":"7lr2" + }, { "sim":51.0, "partner":"5ctt" @@ -914808,10 +918543,6 @@ "sim":51.0, "partner":"3cmj" }, - { - "sim":51.0, - "partner":"6oi8" - }, { "sim":51.0, "partner":"4mv1" @@ -914850,11 +918581,7 @@ }, { "sim":51.0, - "partner":"2gps" - }, - { - "sim":51.0, - "partner":"6oi9" + "partner":"6oi8" }, { "sim":51.0, @@ -914874,11 +918601,11 @@ }, { "sim":51.0, - "partner":"8u41" + "partner":"2gps" }, { "sim":51.0, - "partner":"8u42" + "partner":"6oi9" }, { "sim":51.0, @@ -914886,15 +918613,19 @@ }, { "sim":51.0, - "partner":"8ux5" + "partner":"8u41" }, { "sim":51.0, - "partner":"3oqc" + "partner":"8u42" }, { "sim":51.0, - "partner":"6x0h" + "partner":"8ux5" + }, + { + "sim":51.0, + "partner":"3oqc" }, { "sim":51.0, @@ -914912,6 +918643,10 @@ "sim":51.0, "partner":"6jzs" }, + { + "sim":51.0, + "partner":"6x0h" + }, { "sim":51.0, "partner":"5v2d" @@ -914930,15 +918665,15 @@ }, { "sim":51.0, - "partner":"4dqw" + "partner":"6gjv" }, { "sim":51.0, - "partner":"6gjv" + "partner":"6gk9" }, { "sim":51.0, - "partner":"6gk9" + "partner":"4dqw" }, { "sim":51.0, @@ -915048,10 +918783,6 @@ "sim":51.0, "partner":"4lh3" }, - { - "sim":51.0, - "partner":"5wm2" - }, { "sim":51.0, "partner":"5wm3" @@ -915072,6 +918803,10 @@ "sim":51.0, "partner":"5wm7" }, + { + "sim":51.0, + "partner":"5wm2" + }, { "sim":51.0, "partner":"3bdl" @@ -915082,7 +918817,7 @@ }, { "sim":51.0, - "partner":"5m12" + "partner":"6gwg" }, { "sim":51.0, @@ -915090,31 +918825,31 @@ }, { "sim":51.0, - "partner":"6gwf" + "partner":"6gta" }, { "sim":51.0, - "partner":"6gwg" + "partner":"5m16" }, { "sim":51.0, - "partner":"5m16" + "partner":"6gvd" }, { "sim":51.0, - "partner":"6gta" + "partner":"5m0x" }, { "sim":51.0, - "partner":"6gvd" + "partner":"6gx8" }, { "sim":51.0, - "partner":"5m0x" + "partner":"5m12" }, { "sim":51.0, - "partner":"6gx8" + "partner":"6gwf" }, { "sim":51.0, @@ -915154,11 +918889,11 @@ }, { "sim":51.0, - "partner":"3i39" + "partner":"7err" }, { "sim":51.0, - "partner":"7err" + "partner":"3i39" }, { "sim":51.0, @@ -915186,15 +918921,15 @@ }, { "sim":51.0, - "partner":"7w1c" + "partner":"7w1d" }, { "sim":51.0, - "partner":"7w1d" + "partner":"7w1e" }, { "sim":51.0, - "partner":"7w1e" + "partner":"7w1c" }, { "sim":51.0, @@ -915254,11 +918989,11 @@ }, { "sim":51.0, - "partner":"3l7r" + "partner":"3t0c" }, { "sim":51.0, - "partner":"3t0c" + "partner":"3l7r" }, { "sim":51.0, @@ -915330,11 +919065,11 @@ }, { "sim":50.0, - "partner":"2jop" + "partner":"1te4" }, { "sim":50.0, - "partner":"1te4" + "partner":"2jop" }, { "sim":50.0, @@ -915430,19 +919165,19 @@ }, { "sim":50.0, - "partner":"4gzc" + "partner":"4gzd" }, { "sim":50.0, - "partner":"4gzd" + "partner":"4gzc" }, { "sim":50.0, - "partner":"4ay3" + "partner":"6xgt" }, { "sim":50.0, - "partner":"6xgt" + "partner":"4ay3" }, { "sim":50.0, @@ -915454,15 +919189,15 @@ }, { "sim":50.0, - "partner":"2h16" + "partner":"8ar6" }, { "sim":50.0, - "partner":"8ar6" + "partner":"8ar9" }, { "sim":50.0, - "partner":"8ar9" + "partner":"2h16" }, { "sim":50.0, @@ -915680,10 +919415,6 @@ "sim":50.0, "partner":"6azo" }, - { - "sim":50.0, - "partner":"5tgs" - }, { "sim":50.0, "partner":"8w8h" @@ -915694,7 +919425,7 @@ }, { "sim":50.0, - "partner":"6t2r" + "partner":"5tgs" }, { "sim":50.0, @@ -915702,12 +919433,16 @@ }, { "sim":50.0, - "partner":"6ubb" + "partner":"6t2r" }, { "sim":50.0, "partner":"6ub8" }, + { + "sim":50.0, + "partner":"6ubb" + }, { "sim":50.0, "partner":"6uba" @@ -915744,10 +919479,6 @@ "sim":50.0, "partner":"5c12" }, - { - "sim":50.0, - "partner":"6hxo" - }, { "sim":50.0, "partner":"7lnt" @@ -915772,6 +919503,10 @@ "sim":50.0, "partner":"6hxn" }, + { + "sim":50.0, + "partner":"6hxo" + }, { "sim":50.0, "partner":"7n9d" @@ -915792,10 +919527,6 @@ "sim":50.0, "partner":"1u6h" }, - { - "sim":50.0, - "partner":"2wk1" - }, { "sim":50.0, "partner":"6ypa" @@ -915806,12 +919537,16 @@ }, { "sim":50.0, - "partner":"4rni" + "partner":"2wk1" }, { "sim":50.0, "partner":"4rnj" }, + { + "sim":50.0, + "partner":"4rni" + }, { "sim":50.0, "partner":"3jyy" @@ -915878,11 +919613,11 @@ }, { "sim":50.0, - "partner":"5lsg" + "partner":"6t9c" }, { "sim":50.0, - "partner":"6t9c" + "partner":"5lsg" }, { "sim":50.0, @@ -915896,10 +919631,6 @@ "sim":50.0, "partner":"8rej" }, - { - "sim":50.0, - "partner":"3s3h" - }, { "sim":50.0, "partner":"4gxn" @@ -915924,6 +919655,10 @@ "sim":50.0, "partner":"4gw3" }, + { + "sim":50.0, + "partner":"3s3h" + }, { "sim":50.0, "partner":"5dh0" @@ -915958,19 +919693,19 @@ }, { "sim":50.0, - "partner":"8u05" + "partner":"6l86" }, { "sim":50.0, - "partner":"8u06" + "partner":"8u05" }, { "sim":50.0, - "partner":"8u07" + "partner":"8u06" }, { "sim":50.0, - "partner":"6l86" + "partner":"8u07" }, { "sim":50.0, @@ -916016,17 +919751,13 @@ "sim":50.0, "partner":"3d7r" }, - { - "sim":50.0, - "partner":"5z75" - }, { "sim":50.0, "partner":"3utn" }, { "sim":50.0, - "partner":"2pzm" + "partner":"5z75" }, { "sim":50.0, @@ -916038,20 +919769,24 @@ }, { "sim":50.0, - "partner":"6lcn" + "partner":"2pzm" }, { "sim":50.0, - "partner":"7btm" + "partner":"7bsx" }, { "sim":50.0, - "partner":"7bsx" + "partner":"7btm" }, { "sim":50.0, "partner":"3h7r" }, + { + "sim":50.0, + "partner":"6lcn" + }, { "sim":50.0, "partner":"4zck" @@ -916092,14 +919827,6 @@ "sim":50.0, "partner":"2f9y" }, - { - "sim":50.0, - "partner":"5tyq" - }, - { - "sim":50.0, - "partner":"5u19" - }, { "sim":50.0, "partner":"5u0n" @@ -916128,6 +919855,14 @@ "sim":50.0, "partner":"5u1i" }, + { + "sim":50.0, + "partner":"5tyq" + }, + { + "sim":50.0, + "partner":"5u19" + }, { "sim":50.0, "partner":"3civ" @@ -916156,10 +919891,6 @@ "sim":50.0, "partner":"4ypv" }, - { - "sim":50.0, - "partner":"7ajm" - }, { "sim":50.0, "partner":"7a4r" @@ -916178,31 +919909,15 @@ }, { "sim":50.0, - "partner":"7a19" - }, - { - "sim":50.0, - "partner":"7a1a" - }, - { - "sim":50.0, - "partner":"7a53" - }, - { - "sim":50.0, - "partner":"7ajw" - }, - { - "sim":50.0, - "partner":"7akb" + "partner":"7ajm" }, { "sim":50.0, - "partner":"7ajy" + "partner":"7a19" }, { "sim":50.0, - "partner":"7a5l" + "partner":"7a1a" }, { "sim":50.0, @@ -916264,10 +919979,30 @@ "sim":50.0, "partner":"7aka" }, + { + "sim":50.0, + "partner":"7a53" + }, { "sim":50.0, "partner":"7akl" }, + { + "sim":50.0, + "partner":"7ajw" + }, + { + "sim":50.0, + "partner":"7akb" + }, + { + "sim":50.0, + "partner":"7ajy" + }, + { + "sim":50.0, + "partner":"7a5l" + }, { "sim":50.0, "partner":"3tn3" @@ -916338,15 +920073,15 @@ }, { "sim":50.0, - "partner":"7f6d" + "partner":"8uat" }, { "sim":50.0, - "partner":"8uat" + "partner":"8uaj" }, { "sim":50.0, - "partner":"8uaj" + "partner":"7f6d" }, { "sim":50.0, @@ -916358,11 +920093,11 @@ }, { "sim":50.0, - "partner":"5f5m" + "partner":"5f5o" }, { "sim":50.0, - "partner":"5f5o" + "partner":"5f5m" }, { "sim":50.0, @@ -916372,10 +920107,6 @@ "sim":50.0, "partner":"4ot7" }, - { - "sim":50.0, - "partner":"6put" - }, { "sim":50.0, "partner":"6puw" @@ -916390,15 +920121,15 @@ }, { "sim":50.0, - "partner":"5u1c" + "partner":"6puz" }, { "sim":50.0, - "partner":"6puz" + "partner":"5u1c" }, { "sim":50.0, - "partner":"7azd" + "partner":"6put" }, { "sim":50.0, @@ -916432,13 +920163,17 @@ "sim":50.0, "partner":"7az8" }, + { + "sim":50.0, + "partner":"7azg" + }, { "sim":50.0, "partner":"5x06" }, { "sim":50.0, - "partner":"7azg" + "partner":"7azc" }, { "sim":50.0, @@ -916446,11 +920181,11 @@ }, { "sim":50.0, - "partner":"7azc" + "partner":"3ban" }, { "sim":50.0, - "partner":"3ban" + "partner":"7azd" }, { "sim":50.0, @@ -916458,11 +920193,11 @@ }, { "sim":50.0, - "partner":"6wa9" + "partner":"6wa6" }, { "sim":50.0, - "partner":"6wa6" + "partner":"6wa9" }, { "sim":50.0, @@ -916572,10 +920307,6 @@ "sim":50.0, "partner":"4bko" }, - { - "sim":50.0, - "partner":"5cu7" - }, { "sim":50.0, "partner":"4fdt" @@ -916588,6 +920319,10 @@ "sim":50.0, "partner":"5cx4" }, + { + "sim":50.0, + "partner":"5cu7" + }, { "sim":50.0, "partner":"6hr7" @@ -916602,15 +920337,15 @@ }, { "sim":50.0, - "partner":"7d88" + "partner":"8w72" }, { "sim":50.0, - "partner":"7d89" + "partner":"7d88" }, { "sim":50.0, - "partner":"8w72" + "partner":"7d89" }, { "sim":50.0, @@ -916668,10 +920403,6 @@ "sim":50.0, "partner":"3nmz" }, - { - "sim":50.0, - "partner":"7tfc" - }, { "sim":50.0, "partner":"7d4k" @@ -916684,6 +920415,10 @@ "sim":50.0, "partner":"7d4n" }, + { + "sim":50.0, + "partner":"7tfc" + }, { "sim":50.0, "partner":"4j1q" @@ -916692,6 +920427,18 @@ "sim":50.0, "partner":"4j1s" }, + { + "sim":50.0, + "partner":"8wn5" + }, + { + "sim":50.0, + "partner":"8wn6" + }, + { + "sim":50.0, + "partner":"8wna" + }, { "sim":50.0, "partner":"2hp0" @@ -916712,17 +920459,13 @@ "sim":50.0, "partner":"8tfc" }, - { - "sim":50.0, - "partner":"8ufj" - }, { "sim":50.0, "partner":"3s6k" }, { "sim":50.0, - "partner":"2wc4" + "partner":"8ufj" }, { "sim":50.0, @@ -916850,16 +920593,20 @@ }, { "sim":50.0, - "partner":"6j0u" + "partner":"2wc4" }, { "sim":50.0, - "partner":"6ak4" + "partner":"6j0u" }, { "sim":50.0, "partner":"6aej" }, + { + "sim":50.0, + "partner":"6ak4" + }, { "sim":50.0, "partner":"6wiu" @@ -916874,11 +920621,11 @@ }, { "sim":50.0, - "partner":"4dqv" + "partner":"4u5q" }, { "sim":50.0, - "partner":"4u5q" + "partner":"4dqv" }, { "sim":50.0, @@ -916904,10 +920651,6 @@ "sim":50.0, "partner":"3khz" }, - { - "sim":50.0, - "partner":"4ie7" - }, { "sim":50.0, "partner":"4cxw" @@ -916926,15 +920669,15 @@ }, { "sim":50.0, - "partner":"4idz" + "partner":"7e8z" }, { "sim":50.0, - "partner":"4ie0" + "partner":"4idz" }, { "sim":50.0, - "partner":"7e8z" + "partner":"4ie0" }, { "sim":50.0, @@ -916952,6 +920695,10 @@ "sim":50.0, "partner":"4qho" }, + { + "sim":50.0, + "partner":"4ie7" + }, { "sim":50.0, "partner":"6rim" @@ -916992,14 +920739,6 @@ "sim":50.0, "partner":"3n6r" }, - { - "sim":50.0, - "partner":"8aq3" - }, - { - "sim":50.0, - "partner":"8aq4" - }, { "sim":50.0, "partner":"7aci" @@ -917008,10 +920747,6 @@ "sim":50.0, "partner":"8b0k" }, - { - "sim":50.0, - "partner":"5n6h" - }, { "sim":50.0, "partner":"8b0l" @@ -917024,6 +920759,10 @@ "sim":50.0, "partner":"8b0n" }, + { + "sim":50.0, + "partner":"5n6h" + }, { "sim":50.0, "partner":"8b0o" @@ -917040,6 +920779,14 @@ "sim":50.0, "partner":"5n6l" }, + { + "sim":50.0, + "partner":"8aq3" + }, + { + "sim":50.0, + "partner":"8aq4" + }, { "sim":50.0, "partner":"7lha" @@ -917108,10 +920855,6 @@ "sim":50.0, "partner":"3i3l" }, - { - "sim":50.0, - "partner":"7rpw" - }, { "sim":50.0, "partner":"2hiv" @@ -917128,6 +920871,10 @@ "sim":50.0, "partner":"7rpo" }, + { + "sim":50.0, + "partner":"7rpw" + }, { "sim":50.0, "partner":"3tj1" @@ -917172,10 +920919,6 @@ "sim":50.0, "partner":"7p1g" }, - { - "sim":50.0, - "partner":"6edw" - }, { "sim":50.0, "partner":"6edz" @@ -917186,23 +920929,15 @@ }, { "sim":50.0, - "partner":"8bou" - }, - { - "sim":50.0, - "partner":"7p1h" - }, - { - "sim":50.0, - "partner":"3ahc" + "partner":"6edw" }, { "sim":50.0, - "partner":"3ahd" + "partner":"8bou" }, { "sim":50.0, - "partner":"3ahe" + "partner":"7p1h" }, { "sim":50.0, @@ -917226,19 +920961,23 @@ }, { "sim":50.0, - "partner":"5fau" + "partner":"3ahc" }, { "sim":50.0, - "partner":"6nd3" + "partner":"3ahd" }, { "sim":50.0, - "partner":"4j3t" + "partner":"3ahe" }, { "sim":50.0, - "partner":"4j3u" + "partner":"5fau" + }, + { + "sim":50.0, + "partner":"6nd3" }, { "sim":50.0, @@ -917258,7 +920997,11 @@ }, { "sim":50.0, - "partner":"5y1h" + "partner":"4j3t" + }, + { + "sim":50.0, + "partner":"4j3u" }, { "sim":50.0, @@ -917306,11 +921049,11 @@ }, { "sim":50.0, - "partner":"7s6b" + "partner":"5y1h" }, { "sim":50.0, - "partner":"7o3m" + "partner":"7s6b" }, { "sim":50.0, @@ -917322,11 +921065,11 @@ }, { "sim":50.0, - "partner":"7c6o" + "partner":"7o3m" }, { "sim":50.0, - "partner":"6yt0" + "partner":"7c6o" }, { "sim":50.0, @@ -917343,6 +921086,10 @@ { "sim":50.0, "partner":"6ytj" + }, + { + "sim":50.0, + "partner":"6yt0" } ], "struct_thr_sim_designed":[ @@ -917449,123 +921196,123 @@ ], "subtitle":"Crystal structure of the reconstruction of the worst case of the ancestral triosephosphate isomerase of the last opisthokont common ancestor obtained by bayesian inference", "tags":[ - "triose phosphate isomerase", + "isomerase", "ancestral sequence reconstruction", - "isomerase" + "triose phosphate isomerase" ], "keywords":[ - "work", - "tims", - "analysis", - "evolution", - "unfolding", - "lineages", - "evidence", - "oligomers", - "monomeric", - "located", - "part", - "bonds", - "conserved", - "test", - "isomerase", - "physicochemical", "opisthokonts", - "protozoan", - "reconstruction", - "sequences", - "robustness", - "equilibrium", - "structure", - "monomer", - "applied", - "oligomer", - "resembles", - "unstable", - "spectroscopic", + "tot", + "hydrodynamic", + "well", + "opisthokonta", + "presence", + "differences", + "bottom", + "locatims", "locatim", - "structured", - "reversible", - "resembling", - "reached", - "similar", - "infer", - "obligated", - "calorimetric", + "unstable", + "parameters", + "resembles", + "physicochemical", + "study", "indicated", - "although", - "strongly", - "locatims", - "presence", - "used", - "ancestral", - "comparative", - "structures", - "transitions", - "function", + "unfolding", "showed", - "triosephosphate", - "intermediates", + "equilibrium", "extensive", + "test", + "catalytic", + "two", + "infer", + "lineages", + "similar", + "worst", + "reconstructed", "shows", - "coupled", + "conformational", + "isomerase", + "ones", + "intermediates", + "although", + "last", + "case", + "strongly", + "triosephosphate", + "stability", + "part", + "evidence", + "characterization", + "several", + "ancestral", "hydrogen", "inference", - "properties", - "previously", - "stability", - "monomers", - "bottom", + "found", + "reached", + "\u03b4g", + "resembling", + "evolution", "higher", - "common", - "worst", - "methodologies", - "catalytic", - "temperature", - "four", - "unf", "diverged", - "observed", - "several", - "melting", - "characterization", - "confidence", - "rather", - "\u03b4g", - "high", - "sequence", - "parameters", + "robustness", + "four", + "monomer", + "barrel", + "correlation", "increase", + "spectroscopic", + "calorimetric", + "work", + "used", "extant", - "notably", - "ancestor", - "ones", - "tim", - "hydrodynamic", + "different", + "transitions", + "monomers", + "properties", + "bonds", + "also", + "reversible", + "confidence", + "inactive", + "methodologies", + "oligomer", + "unf", "plausible", + "notably", + "sequence", + "applied", + "common", "3d", - "opisthokonta", - "conformational", - "estimated", - "also", - "study", + "analysis", + "coupled", + "sequences", + "comparative", + "conserved", + "rather", + "observed", + "structures", + "reconstruction", + "oligomers", + "previously", + "structured", + "structure", + "monomeric", "fungi", - "barrel", - "tot", - "well", - "last", - "different", - "found", - "two", - "reconstructed", - "inactive", + "scenario", + "temperature", + "biophysical", + "function", + "melting", + "obligated", "energetics", + "located", + "high", + "estimated", + "tim", + "tims", + "ancestor", "animals", - "differences", - "scenario", - "case", - "correlation", - "biophysical" + "protozoan" ], "release_date":"2024-09-04", "publication":"\"Stable monomers in the ancestral sequence reconstruction of the last opisthokont common ancestor of dimeric triosephosphate isomerase\", Protein Sci., 33, e5134-e5134", @@ -917598,27 +921345,27 @@ "seq_thr_sim_designed":[ { "sim":504.0, - "partner":"8v2w" + "partner":"8v09" }, { "sim":504.0, - "partner":"8v09" + "partner":"8v2w" }, { "sim":487.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":487.0, - "partner":"8w05" + "partner":"8w06" }, { "sim":483.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":483.0, - "partner":"8w08" + "partner":"8v0a" }, { "sim":53.0, @@ -917626,11 +921373,11 @@ }, { "sim":51.0, - "partner":"8jpa" + "partner":"8hdv" }, { "sim":51.0, - "partner":"8hdv" + "partner":"8jpa" }, { "sim":51.0, @@ -917756,27 +921503,27 @@ }, { "sim":342.0, - "partner":"1r2s" + "partner":"4owg" }, { "sim":342.0, - "partner":"1r2t" + "partner":"1r2r" }, { "sim":342.0, - "partner":"4owg" + "partner":"1hti" }, { "sim":342.0, - "partner":"1hti" + "partner":"1r2s" }, { "sim":342.0, - "partner":"1r2r" + "partner":"1sw3" }, { "sim":342.0, - "partner":"1sw3" + "partner":"1r2t" }, { "sim":342.0, @@ -917828,11 +921575,11 @@ }, { "sim":339.0, - "partner":"8tim" + "partner":"1tph" }, { "sim":339.0, - "partner":"1tph" + "partner":"8tim" }, { "sim":339.0, @@ -917920,15 +921667,15 @@ }, { "sim":312.0, - "partner":"8j7c" + "partner":"4gnj" }, { "sim":312.0, - "partner":"8jbp" + "partner":"8j7c" }, { "sim":312.0, - "partner":"4gnj" + "partner":"8jbp" }, { "sim":305.0, @@ -917940,15 +921687,15 @@ }, { "sim":296.0, - "partner":"2ypi" + "partner":"1ypi" }, { "sim":296.0, - "partner":"1ypi" + "partner":"7tim" }, { "sim":296.0, - "partner":"7tim" + "partner":"2ypi" }, { "sim":295.0, @@ -917972,11 +921719,11 @@ }, { "sim":287.0, - "partner":"1nf0" + "partner":"1ney" }, { "sim":287.0, - "partner":"1ney" + "partner":"1nf0" }, { "sim":285.0, @@ -917988,59 +921735,59 @@ }, { "sim":284.0, - "partner":"7az3" + "partner":"1n55" }, { "sim":284.0, - "partner":"2vxn" + "partner":"7az9" }, { "sim":284.0, - "partner":"7az4" + "partner":"7aza" }, { "sim":284.0, - "partner":"1n55" + "partner":"2y61" }, { "sim":284.0, - "partner":"7az9" + "partner":"2y62" }, { "sim":284.0, - "partner":"7aza" + "partner":"2y63" }, { "sim":284.0, - "partner":"2y61" + "partner":"7abx" }, { "sim":284.0, - "partner":"2y62" + "partner":"7az3" }, { "sim":284.0, - "partner":"2y63" + "partner":"1qds" }, { "sim":284.0, - "partner":"1if2" + "partner":"7az4" }, { "sim":284.0, - "partner":"7abx" + "partner":"1if2" }, { "sim":284.0, - "partner":"1qds" + "partner":"2vxn" }, { "sim":284.0, - "partner":"4o50" + "partner":"4o53" }, { "sim":284.0, - "partner":"4o53" + "partner":"4o50" }, { "sim":283.0, @@ -918084,11 +921831,11 @@ }, { "sim":282.0, - "partner":"7qh0" + "partner":"4hhp" }, { "sim":282.0, - "partner":"4hhp" + "partner":"7qh0" }, { "sim":282.0, @@ -918110,10 +921857,6 @@ "sim":280.0, "partner":"1iig" }, - { - "sim":280.0, - "partner":"2v0t" - }, { "sim":280.0, "partner":"4jeq" @@ -918148,15 +921891,19 @@ }, { "sim":280.0, - "partner":"4tim" + "partner":"2v0t" }, { "sim":280.0, - "partner":"2v5l" + "partner":"6tim" }, { "sim":280.0, - "partner":"6tim" + "partner":"4tim" + }, + { + "sim":280.0, + "partner":"2v5l" }, { "sim":279.0, @@ -918176,23 +921923,23 @@ }, { "sim":278.0, - "partner":"1kv5" + "partner":"5i3j" }, { "sim":278.0, - "partner":"5i3i" + "partner":"5i3k" }, { "sim":278.0, - "partner":"5i3j" + "partner":"5i3f" }, { "sim":278.0, - "partner":"5i3k" + "partner":"5i3i" }, { "sim":278.0, - "partner":"5i3f" + "partner":"1kv5" }, { "sim":278.0, @@ -918288,24 +922035,20 @@ }, { "sim":250.0, - "partner":"2vfd" + "partner":"4ywi" }, { "sim":250.0, - "partner":"2vfe" + "partner":"2vfd" }, { "sim":250.0, - "partner":"4ywi" + "partner":"2vfe" }, { "sim":249.0, "partner":"2y70" }, - { - "sim":249.0, - "partner":"1lzo" - }, { "sim":249.0, "partner":"1lyx" @@ -918340,15 +922083,11 @@ }, { "sim":249.0, - "partner":"1m7p" - }, - { - "sim":248.0, - "partner":"5gv4" + "partner":"1lzo" }, { - "sim":248.0, - "partner":"5gzp" + "sim":249.0, + "partner":"1m7p" }, { "sim":248.0, @@ -918374,6 +922113,14 @@ "sim":248.0, "partner":"5brb" }, + { + "sim":248.0, + "partner":"5gzp" + }, + { + "sim":248.0, + "partner":"5gv4" + }, { "sim":247.0, "partner":"5bmw" @@ -918482,10 +922229,6 @@ "sim":229.0, "partner":"4y96" }, - { - "sim":227.0, - "partner":"3uwz" - }, { "sim":227.0, "partner":"3uwu" @@ -918502,6 +922245,10 @@ "sim":227.0, "partner":"3uwy" }, + { + "sim":227.0, + "partner":"3uwz" + }, { "sim":223.0, "partner":"4mva" @@ -918528,11 +922275,11 @@ }, { "sim":211.0, - "partner":"4iot" + "partner":"1tre" }, { "sim":211.0, - "partner":"1tre" + "partner":"4iot" }, { "sim":208.0, @@ -918762,14 +922509,6 @@ "sim":56.0, "partner":"5ctt" }, - { - "sim":56.0, - "partner":"2yii" - }, - { - "sim":56.0, - "partner":"4v2r" - }, { "sim":56.0, "partner":"4c5u" @@ -918790,10 +922529,18 @@ "sim":56.0, "partner":"4c5r" }, + { + "sim":56.0, + "partner":"2yii" + }, { "sim":56.0, "partner":"4v2q" }, + { + "sim":56.0, + "partner":"4v2r" + }, { "sim":55.0, "partner":"2jve" @@ -918812,43 +922559,39 @@ }, { "sim":55.0, - "partner":"5y0f" - }, - { - "sim":55.0, - "partner":"5y0g" + "partner":"4nns" }, { "sim":55.0, - "partner":"4nns" + "partner":"4nnt" }, { "sim":55.0, - "partner":"4nnt" + "partner":"6ljs" }, { "sim":55.0, - "partner":"5y12" + "partner":"6ljt" }, { "sim":55.0, - "partner":"6ljs" + "partner":"8wdx" }, { "sim":55.0, - "partner":"5d45" + "partner":"5y12" }, { "sim":55.0, - "partner":"5y13" + "partner":"6lju" }, { "sim":55.0, - "partner":"6ljt" + "partner":"5d45" }, { "sim":55.0, - "partner":"6lju" + "partner":"5y13" }, { "sim":55.0, @@ -918872,7 +922615,7 @@ }, { "sim":55.0, - "partner":"8wdx" + "partner":"8we3" }, { "sim":55.0, @@ -918884,11 +922627,15 @@ }, { "sim":55.0, - "partner":"8we3" + "partner":"5y0x" }, { "sim":55.0, - "partner":"5y0x" + "partner":"5y0f" + }, + { + "sim":55.0, + "partner":"5y0g" }, { "sim":55.0, @@ -918956,15 +922703,15 @@ }, { "sim":55.0, - "partner":"7lr2" + "partner":"7lr6" }, { "sim":55.0, - "partner":"7lr6" + "partner":"7lr1" }, { "sim":55.0, - "partner":"7lr1" + "partner":"7lr2" }, { "sim":55.0, @@ -918998,10 +922745,6 @@ "sim":55.0, "partner":"3udt" }, - { - "sim":55.0, - "partner":"2cj9" - }, { "sim":55.0, "partner":"2cja" @@ -919016,12 +922759,16 @@ }, { "sim":55.0, - "partner":"4c5s" + "partner":"2cj9" }, { "sim":55.0, "partner":"4cq5" }, + { + "sim":55.0, + "partner":"4c5s" + }, { "sim":54.0, "partner":"4pu3" @@ -919086,10 +922833,6 @@ "sim":54.0, "partner":"2zvw" }, - { - "sim":54.0, - "partner":"5mit" - }, { "sim":54.0, "partner":"5mjk" @@ -919114,6 +922857,10 @@ "sim":54.0, "partner":"5mis" }, + { + "sim":54.0, + "partner":"5mit" + }, { "sim":54.0, "partner":"7cgv" @@ -919170,10 +922917,6 @@ "sim":53.0, "partner":"7aby" }, - { - "sim":53.0, - "partner":"5zrk" - }, { "sim":53.0, "partner":"5zrl" @@ -919202,6 +922945,10 @@ "sim":53.0, "partner":"5zri" }, + { + "sim":53.0, + "partner":"5zrk" + }, { "sim":53.0, "partner":"4tns" @@ -919260,15 +923007,15 @@ }, { "sim":53.0, - "partner":"3th5" + "partner":"4gzl" }, { "sim":53.0, - "partner":"4gzl" + "partner":"4gzm" }, { "sim":53.0, - "partner":"4gzm" + "partner":"3th5" }, { "sim":53.0, @@ -919280,15 +923027,15 @@ }, { "sim":53.0, - "partner":"6j0l" + "partner":"6j0g" }, { "sim":53.0, - "partner":"6j0g" + "partner":"6j0k" }, { "sim":53.0, - "partner":"6j0k" + "partner":"6j0l" }, { "sim":53.0, @@ -919312,31 +923059,31 @@ }, { "sim":53.0, - "partner":"5h5a" + "partner":"5h54" }, { "sim":53.0, - "partner":"5h54" + "partner":"5h5a" }, { "sim":53.0, - "partner":"6ihr" + "partner":"6ihv" }, { "sim":53.0, - "partner":"6iht" + "partner":"6ihw" }, { "sim":53.0, - "partner":"6ihu" + "partner":"6ihr" }, { "sim":53.0, - "partner":"6ihv" + "partner":"6iht" }, { "sim":53.0, - "partner":"6ihw" + "partner":"6ihu" }, { "sim":53.0, @@ -919492,15 +923239,15 @@ }, { "sim":53.0, - "partner":"8u41" + "partner":"2fwr" }, { "sim":53.0, - "partner":"8u42" + "partner":"8u41" }, { "sim":53.0, - "partner":"2fwr" + "partner":"8u42" }, { "sim":53.0, @@ -919516,15 +923263,15 @@ }, { "sim":53.0, - "partner":"7mdl" + "partner":"8g9z" }, { "sim":53.0, - "partner":"8g9z" + "partner":"7l1t" }, { "sim":53.0, - "partner":"7l1t" + "partner":"7mdl" }, { "sim":53.0, @@ -919540,11 +923287,11 @@ }, { "sim":53.0, - "partner":"2vbg" + "partner":"2vbf" }, { "sim":53.0, - "partner":"2vbf" + "partner":"2vbg" }, { "sim":53.0, @@ -919598,10 +923345,6 @@ "sim":52.0, "partner":"7rrm" }, - { - "sim":52.0, - "partner":"3vwb" - }, { "sim":52.0, "partner":"3w2a" @@ -919612,11 +923355,11 @@ }, { "sim":52.0, - "partner":"6tr8" + "partner":"3vwb" }, { "sim":52.0, - "partner":"4a41" + "partner":"6tr8" }, { "sim":52.0, @@ -919630,6 +923373,10 @@ "sim":52.0, "partner":"4aax" }, + { + "sim":52.0, + "partner":"4a41" + }, { "sim":52.0, "partner":"3ffl" @@ -919648,11 +923395,11 @@ }, { "sim":52.0, - "partner":"1x24" + "partner":"1zcl" }, { "sim":52.0, - "partner":"1zcl" + "partner":"1x24" }, { "sim":52.0, @@ -919708,16 +923455,12 @@ }, { "sim":52.0, - "partner":"7o2t" + "partner":"6z17" }, { "sim":52.0, "partner":"7o2u" }, - { - "sim":52.0, - "partner":"6z17" - }, { "sim":52.0, "partner":"6yz3" @@ -919734,25 +923477,29 @@ "sim":52.0, "partner":"6z5k" }, + { + "sim":52.0, + "partner":"7o2t" + }, { "sim":52.0, "partner":"4iqz" }, { "sim":52.0, - "partner":"4bmx" + "partner":"4bmz" }, { "sim":52.0, - "partner":"4bmy" + "partner":"4bn0" }, { "sim":52.0, - "partner":"4bmz" + "partner":"4bmx" }, { "sim":52.0, - "partner":"4bn0" + "partner":"4bmy" }, { "sim":52.0, @@ -919760,11 +923507,11 @@ }, { "sim":52.0, - "partner":"6ubb" + "partner":"6ub8" }, { "sim":52.0, - "partner":"6ub8" + "partner":"6ubb" }, { "sim":52.0, @@ -919826,17 +923573,13 @@ "sim":52.0, "partner":"4rw5" }, - { - "sim":52.0, - "partner":"3la8" - }, { "sim":52.0, "partner":"3lba" }, { "sim":52.0, - "partner":"8wlb" + "partner":"3la8" }, { "sim":52.0, @@ -919852,15 +923595,19 @@ }, { "sim":52.0, - "partner":"4w7v" + "partner":"8wlb" }, { "sim":52.0, - "partner":"4w7w" + "partner":"4w7u" }, { "sim":52.0, - "partner":"4w7u" + "partner":"4w7v" + }, + { + "sim":52.0, + "partner":"4w7w" }, { "sim":52.0, @@ -919892,11 +923639,11 @@ }, { "sim":52.0, - "partner":"7js3" + "partner":"8g5w" }, { "sim":52.0, - "partner":"8g5w" + "partner":"7js3" }, { "sim":52.0, @@ -919934,10 +923681,6 @@ "sim":52.0, "partner":"4rhq" }, - { - "sim":52.0, - "partner":"5g6t" - }, { "sim":52.0, "partner":"5g5u" @@ -919962,6 +923705,10 @@ "sim":52.0, "partner":"5g5k" }, + { + "sim":52.0, + "partner":"5g6t" + }, { "sim":52.0, "partner":"4h27" @@ -919972,15 +923719,15 @@ }, { "sim":52.0, - "partner":"8wov" + "partner":"8wop" }, { "sim":52.0, - "partner":"8wow" + "partner":"8wov" }, { "sim":52.0, - "partner":"8wop" + "partner":"8wow" }, { "sim":52.0, @@ -920012,15 +923759,15 @@ }, { "sim":52.0, - "partner":"5dvi" + "partner":"5dvj" }, { "sim":52.0, - "partner":"5dvj" + "partner":"5dvf" }, { "sim":52.0, - "partner":"5dvf" + "partner":"5dvi" }, { "sim":52.0, @@ -920134,10 +923881,6 @@ "sim":51.0, "partner":"1nyn" }, - { - "sim":51.0, - "partner":"4hmr" - }, { "sim":51.0, "partner":"4hls" @@ -920150,6 +923893,10 @@ "sim":51.0, "partner":"1yx3" }, + { + "sim":51.0, + "partner":"4hmr" + }, { "sim":51.0, "partner":"1w6v" @@ -920246,21 +923993,17 @@ "sim":51.0, "partner":"7vmq" }, - { - "sim":51.0, - "partner":"7ccl" - }, { "sim":51.0, "partner":"7ccm" }, { "sim":51.0, - "partner":"5eg9" + "partner":"7ekv" }, { "sim":51.0, - "partner":"7ekv" + "partner":"5eg9" }, { "sim":51.0, @@ -920274,6 +924017,10 @@ "sim":51.0, "partner":"7efx" }, + { + "sim":51.0, + "partner":"7ccl" + }, { "sim":51.0, "partner":"2cwo" @@ -920302,10 +924049,6 @@ "sim":51.0, "partner":"3vco" }, - { - "sim":51.0, - "partner":"4c76" - }, { "sim":51.0, "partner":"3zez" @@ -920340,15 +924083,15 @@ }, { "sim":51.0, - "partner":"1t57" + "partner":"4c76" }, { "sim":51.0, - "partner":"3vwv" + "partner":"1t57" }, { "sim":51.0, - "partner":"3l1u" + "partner":"3vwv" }, { "sim":51.0, @@ -920368,19 +924111,19 @@ }, { "sim":51.0, - "partner":"7p47" + "partner":"3l1u" }, { "sim":51.0, - "partner":"2kn6" + "partner":"7p47" }, { "sim":51.0, - "partner":"6a4c" + "partner":"2kn6" }, { "sim":51.0, - "partner":"6ueo" + "partner":"6a4c" }, { "sim":51.0, @@ -920394,13 +924137,17 @@ "sim":51.0, "partner":"2q16" }, + { + "sim":51.0, + "partner":"6uer" + }, { "sim":51.0, "partner":"2pyu" }, { "sim":51.0, - "partner":"6uer" + "partner":"6ueo" }, { "sim":51.0, @@ -920508,11 +924255,11 @@ }, { "sim":51.0, - "partner":"1z5z" + "partner":"5umi" }, { "sim":51.0, - "partner":"5umi" + "partner":"1z5z" }, { "sim":51.0, @@ -920530,14 +924277,6 @@ "sim":51.0, "partner":"5vrc" }, - { - "sim":51.0, - "partner":"3quo" - }, - { - "sim":51.0, - "partner":"3qvf" - }, { "sim":51.0, "partner":"3qur" @@ -920566,6 +924305,14 @@ "sim":51.0, "partner":"3qun" }, + { + "sim":51.0, + "partner":"3quo" + }, + { + "sim":51.0, + "partner":"3qvf" + }, { "sim":51.0, "partner":"7xm0" @@ -920602,10 +924349,6 @@ "sim":51.0, "partner":"3v91" }, - { - "sim":51.0, - "partner":"6wye" - }, { "sim":51.0, "partner":"7vpf" @@ -920618,6 +924361,10 @@ "sim":51.0, "partner":"4ats" }, + { + "sim":51.0, + "partner":"6wye" + }, { "sim":51.0, "partner":"7umj" @@ -920632,11 +924379,11 @@ }, { "sim":51.0, - "partner":"6aa8" + "partner":"7eov" }, { "sim":51.0, - "partner":"7eov" + "partner":"6aa8" }, { "sim":51.0, @@ -920684,51 +924431,51 @@ }, { "sim":51.0, - "partner":"7q2b" + "partner":"7q2f" }, { "sim":51.0, - "partner":"3ha3" + "partner":"7q2g" }, { "sim":51.0, - "partner":"7q2c" + "partner":"7q2h" }, { "sim":51.0, - "partner":"7q2d" + "partner":"3ha5" }, { "sim":51.0, - "partner":"7q2e" + "partner":"2fk7" }, { "sim":51.0, - "partner":"7q2f" + "partner":"2fk8" }, { "sim":51.0, - "partner":"7q2g" + "partner":"3ha7" }, { "sim":51.0, - "partner":"7q2h" + "partner":"7q2b" }, { "sim":51.0, - "partner":"3ha5" + "partner":"7q2c" }, { "sim":51.0, - "partner":"2fk7" + "partner":"3ha3" }, { "sim":51.0, - "partner":"2fk8" + "partner":"7q2d" }, { "sim":51.0, - "partner":"3ha7" + "partner":"7q2e" }, { "sim":51.0, @@ -920874,14 +924621,6 @@ "sim":51.0, "partner":"4hbk" }, - { - "sim":51.0, - "partner":"4fif" - }, - { - "sim":51.0, - "partner":"7s46" - }, { "sim":51.0, "partner":"4fig" @@ -920932,7 +924671,11 @@ }, { "sim":51.0, - "partner":"6sf5" + "partner":"4fif" + }, + { + "sim":51.0, + "partner":"7s46" }, { "sim":51.0, @@ -920940,11 +924683,11 @@ }, { "sim":51.0, - "partner":"3ren" + "partner":"6sf5" }, { "sim":51.0, - "partner":"2ikf" + "partner":"3ren" }, { "sim":51.0, @@ -920996,11 +924739,11 @@ }, { "sim":51.0, - "partner":"5v8y" + "partner":"2ikf" }, { "sim":51.0, - "partner":"5jyf" + "partner":"5v8y" }, { "sim":51.0, @@ -921030,6 +924773,10 @@ "sim":51.0, "partner":"5jye" }, + { + "sim":51.0, + "partner":"5jyf" + }, { "sim":51.0, "partner":"6nxc" @@ -921106,10 +924853,6 @@ "sim":51.0, "partner":"3kzk" }, - { - "sim":51.0, - "partner":"8hmn" - }, { "sim":51.0, "partner":"7o9o" @@ -921120,11 +924863,11 @@ }, { "sim":51.0, - "partner":"7us5" + "partner":"8hmn" }, { "sim":51.0, - "partner":"4m1i" + "partner":"7us5" }, { "sim":51.0, @@ -921140,47 +924883,51 @@ }, { "sim":51.0, - "partner":"7wxl" + "partner":"4m1i" }, { "sim":51.0, - "partner":"7wxm" + "partner":"7wxp" }, { "sim":51.0, - "partner":"7wxn" + "partner":"7wxq" }, { "sim":51.0, - "partner":"7wxo" + "partner":"7wxr" }, { "sim":51.0, - "partner":"7wxp" + "partner":"7xte" }, { "sim":51.0, - "partner":"7wxq" + "partner":"7xtf" }, { "sim":51.0, - "partner":"7wxr" + "partner":"7wxj" }, { "sim":51.0, - "partner":"7xte" + "partner":"7wxk" }, { "sim":51.0, - "partner":"7xtf" + "partner":"7wxl" }, { "sim":51.0, - "partner":"7wxj" + "partner":"7wxm" }, { "sim":51.0, - "partner":"7wxk" + "partner":"7wxn" + }, + { + "sim":51.0, + "partner":"7wxo" }, { "sim":51.0, @@ -921202,10 +924949,6 @@ "sim":51.0, "partner":"1p5j" }, - { - "sim":51.0, - "partner":"3c1y" - }, { "sim":51.0, "partner":"3c1z" @@ -921232,7 +924975,7 @@ }, { "sim":51.0, - "partner":"4zhs" + "partner":"3c1y" }, { "sim":51.0, @@ -921240,19 +924983,19 @@ }, { "sim":51.0, - "partner":"4ltz" + "partner":"4zhs" }, { "sim":51.0, - "partner":"7kj8" + "partner":"3kbk" }, { "sim":51.0, - "partner":"7kj9" + "partner":"6ax9" }, { "sim":51.0, - "partner":"3kbk" + "partner":"7kjd" }, { "sim":51.0, @@ -921260,7 +925003,7 @@ }, { "sim":51.0, - "partner":"6ax9" + "partner":"7kje" }, { "sim":51.0, @@ -921268,39 +925011,31 @@ }, { "sim":51.0, - "partner":"8su2" - }, - { - "sim":51.0, - "partner":"8su3" - }, - { - "sim":51.0, - "partner":"7kjd" + "partner":"6axu" }, { "sim":51.0, - "partner":"8su4" + "partner":"7kjf" }, { "sim":51.0, - "partner":"6axu" + "partner":"8su2" }, { "sim":51.0, - "partner":"7kje" + "partner":"7kjg" }, { "sim":51.0, - "partner":"8su5" + "partner":"8su3" }, { "sim":51.0, - "partner":"7kjf" + "partner":"8v3k" }, { "sim":51.0, - "partner":"7kjg" + "partner":"8su4" }, { "sim":51.0, @@ -921308,11 +925043,11 @@ }, { "sim":51.0, - "partner":"3kb9" + "partner":"8su5" }, { "sim":51.0, - "partner":"8v3k" + "partner":"3kb9" }, { "sim":51.0, @@ -921352,7 +925087,15 @@ }, { "sim":51.0, - "partner":"3pz9" + "partner":"7kj8" + }, + { + "sim":51.0, + "partner":"4ltz" + }, + { + "sim":51.0, + "partner":"7kj9" }, { "sim":51.0, @@ -921378,6 +925121,10 @@ "sim":51.0, "partner":"3pzq" }, + { + "sim":51.0, + "partner":"3pz9" + }, { "sim":51.0, "partner":"3fvm" @@ -921404,11 +925151,11 @@ }, { "sim":51.0, - "partner":"4wwv" + "partner":"3bu7" }, { "sim":51.0, - "partner":"3bu7" + "partner":"4wwv" }, { "sim":51.0, @@ -921438,17 +925185,13 @@ "sim":51.0, "partner":"4w61" }, - { - "sim":51.0, - "partner":"2gqn" - }, { "sim":51.0, "partner":"2fq6" }, { "sim":51.0, - "partner":"4euh" + "partner":"2gqn" }, { "sim":51.0, @@ -921460,12 +925203,16 @@ }, { "sim":51.0, - "partner":"5xw2" + "partner":"4euh" }, { "sim":51.0, "partner":"4e2p" }, + { + "sim":51.0, + "partner":"5xw2" + }, { "sim":51.0, "partner":"5hxk" @@ -921506,10 +925253,6 @@ "sim":51.0, "partner":"7ui4" }, - { - "sim":51.0, - "partner":"4q6q" - }, { "sim":51.0, "partner":"4q6m" @@ -921528,31 +925271,31 @@ }, { "sim":51.0, - "partner":"6v99" + "partner":"4q6q" }, { "sim":51.0, - "partner":"6v9a" + "partner":"6v96" }, { "sim":51.0, - "partner":"6v96" + "partner":"6v99" }, { "sim":51.0, - "partner":"3mcm" + "partner":"6v9a" }, { "sim":51.0, - "partner":"3mcn" + "partner":"3mcm" }, { "sim":51.0, - "partner":"3mco" + "partner":"3mcn" }, { "sim":51.0, - "partner":"2imc" + "partner":"3mco" }, { "sim":51.0, @@ -921578,6 +925321,10 @@ "sim":51.0, "partner":"2imb" }, + { + "sim":51.0, + "partner":"2imc" + }, { "sim":51.0, "partner":"7n18" @@ -921626,10 +925373,6 @@ "sim":51.0, "partner":"7tf9" }, - { - "sim":51.0, - "partner":"6oi8" - }, { "sim":51.0, "partner":"4mv1" @@ -921668,11 +925411,7 @@ }, { "sim":51.0, - "partner":"2gps" - }, - { - "sim":51.0, - "partner":"6oi9" + "partner":"6oi8" }, { "sim":51.0, @@ -921692,15 +925431,19 @@ }, { "sim":51.0, - "partner":"4b28" + "partner":"2gps" }, { "sim":51.0, - "partner":"3oqc" + "partner":"6oi9" }, { "sim":51.0, - "partner":"7uji" + "partner":"4b28" + }, + { + "sim":51.0, + "partner":"3oqc" }, { "sim":51.0, @@ -921712,7 +925455,7 @@ }, { "sim":51.0, - "partner":"6x0h" + "partner":"7uji" }, { "sim":51.0, @@ -921722,6 +925465,10 @@ "sim":51.0, "partner":"6x0k" }, + { + "sim":51.0, + "partner":"6x0h" + }, { "sim":51.0, "partner":"6pop" @@ -921752,15 +925499,15 @@ }, { "sim":51.0, - "partner":"4dqw" + "partner":"6gjv" }, { "sim":51.0, - "partner":"6gjv" + "partner":"6gk9" }, { "sim":51.0, - "partner":"6gk9" + "partner":"4dqw" }, { "sim":51.0, @@ -921886,10 +925633,6 @@ "sim":51.0, "partner":"4lh3" }, - { - "sim":51.0, - "partner":"5wm2" - }, { "sim":51.0, "partner":"5wm3" @@ -921910,6 +925653,10 @@ "sim":51.0, "partner":"5wm7" }, + { + "sim":51.0, + "partner":"5wm2" + }, { "sim":51.0, "partner":"3bdl" @@ -921948,11 +925695,11 @@ }, { "sim":51.0, - "partner":"4gyk" + "partner":"4gyj" }, { "sim":51.0, - "partner":"4gyj" + "partner":"4gyk" }, { "sim":51.0, @@ -921960,11 +925707,11 @@ }, { "sim":51.0, - "partner":"3i39" + "partner":"7err" }, { "sim":51.0, - "partner":"7err" + "partner":"3i39" }, { "sim":51.0, @@ -921996,16 +925743,12 @@ }, { "sim":51.0, - "partner":"5uw0" + "partner":"5uw1" }, { "sim":51.0, "partner":"5vnc" }, - { - "sim":51.0, - "partner":"5uw1" - }, { "sim":51.0, "partner":"4xpo" @@ -922030,6 +925773,10 @@ "sim":51.0, "partner":"4xps" }, + { + "sim":51.0, + "partner":"5uw0" + }, { "sim":51.0, "partner":"2d73" @@ -922112,11 +925859,11 @@ }, { "sim":50.0, - "partner":"2jop" + "partner":"1te4" }, { "sim":50.0, - "partner":"1te4" + "partner":"2jop" }, { "sim":50.0, @@ -922228,15 +925975,15 @@ }, { "sim":50.0, - "partner":"4gzc" + "partner":"4gzd" }, { "sim":50.0, - "partner":"4gzd" + "partner":"5zrt" }, { "sim":50.0, - "partner":"5zrt" + "partner":"4gzc" }, { "sim":50.0, @@ -922308,11 +926055,11 @@ }, { "sim":50.0, - "partner":"4kce" + "partner":"8yjm" }, { "sim":50.0, - "partner":"8yjm" + "partner":"4kce" }, { "sim":50.0, @@ -922420,11 +926167,11 @@ }, { "sim":50.0, - "partner":"6ey1" + "partner":"6f0w" }, { "sim":50.0, - "partner":"6f0w" + "partner":"6ey1" }, { "sim":50.0, @@ -922456,47 +926203,47 @@ }, { "sim":50.0, - "partner":"5tgs" + "partner":"5th5" }, { "sim":50.0, - "partner":"5th5" + "partner":"5tgs" }, { "sim":50.0, - "partner":"6t2r" + "partner":"8wbm" }, { "sim":50.0, - "partner":"8wbk" + "partner":"8wbn" }, { "sim":50.0, - "partner":"8wbl" + "partner":"8wbo" }, { "sim":50.0, - "partner":"8wbm" + "partner":"8wbp" }, { "sim":50.0, - "partner":"4nec" + "partner":"8wbq" }, { "sim":50.0, - "partner":"8wbn" + "partner":"4nec" }, { "sim":50.0, - "partner":"8wbo" + "partner":"8wbk" }, { "sim":50.0, - "partner":"8wbp" + "partner":"8wbl" }, { "sim":50.0, - "partner":"8wbq" + "partner":"6t2r" }, { "sim":50.0, @@ -922520,11 +926267,11 @@ }, { "sim":50.0, - "partner":"5c2d" + "partner":"6dli" }, { "sim":50.0, - "partner":"6dli" + "partner":"5c2d" }, { "sim":50.0, @@ -922542,17 +926289,13 @@ "sim":50.0, "partner":"5c12" }, - { - "sim":50.0, - "partner":"6hxo" - }, { "sim":50.0, "partner":"6hxn" }, { "sim":50.0, - "partner":"2wk1" + "partner":"6hxo" }, { "sim":50.0, @@ -922564,12 +926307,16 @@ }, { "sim":50.0, - "partner":"4rni" + "partner":"2wk1" }, { "sim":50.0, "partner":"4rnj" }, + { + "sim":50.0, + "partner":"4rni" + }, { "sim":50.0, "partner":"3jyy" @@ -922618,10 +926365,6 @@ "sim":50.0, "partner":"3l7y" }, - { - "sim":50.0, - "partner":"3s3h" - }, { "sim":50.0, "partner":"4gxn" @@ -922646,6 +926389,10 @@ "sim":50.0, "partner":"4gw3" }, + { + "sim":50.0, + "partner":"3s3h" + }, { "sim":50.0, "partner":"3nib" @@ -922756,19 +926503,19 @@ }, { "sim":50.0, - "partner":"2pzm" + "partner":"2pzk" }, { "sim":50.0, - "partner":"2pzk" + "partner":"2pzl" }, { "sim":50.0, - "partner":"2pzl" + "partner":"2pzm" }, { "sim":50.0, - "partner":"6lcn" + "partner":"7bsx" }, { "sim":50.0, @@ -922776,11 +926523,11 @@ }, { "sim":50.0, - "partner":"7bsx" + "partner":"3h7r" }, { "sim":50.0, - "partner":"3h7r" + "partner":"6lcn" }, { "sim":50.0, @@ -922816,27 +926563,27 @@ }, { "sim":50.0, - "partner":"5tyq" + "partner":"5u0n" }, { "sim":50.0, - "partner":"5u19" + "partner":"5u1e" }, { "sim":50.0, - "partner":"5u0n" + "partner":"5u0t" }, { "sim":50.0, - "partner":"5u1e" + "partner":"5u1i" }, { "sim":50.0, - "partner":"5u0t" + "partner":"5tyq" }, { "sim":50.0, - "partner":"5u1i" + "partner":"5u19" }, { "sim":50.0, @@ -922858,10 +926605,6 @@ "sim":50.0, "partner":"3rny" }, - { - "sim":50.0, - "partner":"7dw8" - }, { "sim":50.0, "partner":"7dwa" @@ -922880,19 +926623,19 @@ }, { "sim":50.0, - "partner":"5xm6" + "partner":"7dw8" }, { "sim":50.0, - "partner":"5xmd" + "partner":"5xm6" }, { "sim":50.0, - "partner":"3i8v" + "partner":"5xmd" }, { "sim":50.0, - "partner":"7ajm" + "partner":"3i8v" }, { "sim":50.0, @@ -922912,31 +926655,15 @@ }, { "sim":50.0, - "partner":"7a19" - }, - { - "sim":50.0, - "partner":"7a1a" - }, - { - "sim":50.0, - "partner":"7a53" - }, - { - "sim":50.0, - "partner":"7ajw" - }, - { - "sim":50.0, - "partner":"7akb" + "partner":"7ajm" }, { "sim":50.0, - "partner":"7ajy" + "partner":"7a19" }, { "sim":50.0, - "partner":"7a5l" + "partner":"7a1a" }, { "sim":50.0, @@ -922998,17 +926725,33 @@ "sim":50.0, "partner":"7aka" }, + { + "sim":50.0, + "partner":"7a53" + }, { "sim":50.0, "partner":"7akl" }, { "sim":50.0, - "partner":"5ysz" + "partner":"7ajw" }, { "sim":50.0, - "partner":"8tne" + "partner":"7akb" + }, + { + "sim":50.0, + "partner":"7ajy" + }, + { + "sim":50.0, + "partner":"7a5l" + }, + { + "sim":50.0, + "partner":"5ysz" }, { "sim":50.0, @@ -923018,6 +926761,10 @@ "sim":50.0, "partner":"6clx" }, + { + "sim":50.0, + "partner":"8tne" + }, { "sim":50.0, "partner":"3wcg" @@ -923064,11 +926811,11 @@ }, { "sim":50.0, - "partner":"5f5m" + "partner":"5f5o" }, { "sim":50.0, - "partner":"5f5o" + "partner":"5f5m" }, { "sim":50.0, @@ -923078,10 +926825,6 @@ "sim":50.0, "partner":"4ot7" }, - { - "sim":50.0, - "partner":"6put" - }, { "sim":50.0, "partner":"6puw" @@ -923096,15 +926839,15 @@ }, { "sim":50.0, - "partner":"5u1c" + "partner":"6puz" }, { "sim":50.0, - "partner":"6puz" + "partner":"5u1c" }, { "sim":50.0, - "partner":"7azd" + "partner":"6put" }, { "sim":50.0, @@ -923136,16 +926879,20 @@ }, { "sim":50.0, - "partner":"5x06" + "partner":"7azg" }, { "sim":50.0, - "partner":"7azg" + "partner":"5x06" }, { "sim":50.0, "partner":"7azc" }, + { + "sim":50.0, + "partner":"7azd" + }, { "sim":50.0, "partner":"6d5a" @@ -923192,15 +926939,15 @@ }, { "sim":50.0, - "partner":"6s0g" + "partner":"7bn6" }, { "sim":50.0, - "partner":"7bn6" + "partner":"6s23" }, { "sim":50.0, - "partner":"6s23" + "partner":"6s0g" }, { "sim":50.0, @@ -923270,10 +927017,6 @@ "sim":50.0, "partner":"4bko" }, - { - "sim":50.0, - "partner":"5cu7" - }, { "sim":50.0, "partner":"4fdt" @@ -923288,7 +927031,7 @@ }, { "sim":50.0, - "partner":"4f6c" + "partner":"5cu7" }, { "sim":50.0, @@ -923298,21 +927041,25 @@ "sim":50.0, "partner":"6hr8" }, + { + "sim":50.0, + "partner":"4f6c" + }, { "sim":50.0, "partner":"8w6z" }, { "sim":50.0, - "partner":"7d88" + "partner":"8w72" }, { "sim":50.0, - "partner":"7d89" + "partner":"7d88" }, { "sim":50.0, - "partner":"8w72" + "partner":"7d89" }, { "sim":50.0, @@ -923378,6 +927125,18 @@ "sim":50.0, "partner":"4j1s" }, + { + "sim":50.0, + "partner":"8wn5" + }, + { + "sim":50.0, + "partner":"8wn6" + }, + { + "sim":50.0, + "partner":"8wna" + }, { "sim":50.0, "partner":"2hp0" @@ -923406,10 +927165,6 @@ "sim":50.0, "partner":"8ufj" }, - { - "sim":50.0, - "partner":"2wc4" - }, { "sim":50.0, "partner":"1oif" @@ -923524,16 +927279,20 @@ }, { "sim":50.0, - "partner":"6j0u" + "partner":"2wc4" }, { "sim":50.0, - "partner":"6ak4" + "partner":"6j0u" }, { "sim":50.0, "partner":"6aej" }, + { + "sim":50.0, + "partner":"6ak4" + }, { "sim":50.0, "partner":"6wiu" @@ -923548,11 +927307,11 @@ }, { "sim":50.0, - "partner":"4dqv" + "partner":"4u5q" }, { "sim":50.0, - "partner":"4u5q" + "partner":"4dqv" }, { "sim":50.0, @@ -923586,10 +927345,6 @@ "sim":50.0, "partner":"6jzs" }, - { - "sim":50.0, - "partner":"4ie7" - }, { "sim":50.0, "partner":"4cxw" @@ -923608,15 +927363,15 @@ }, { "sim":50.0, - "partner":"4idz" + "partner":"7e8z" }, { "sim":50.0, - "partner":"4ie0" + "partner":"4idz" }, { "sim":50.0, - "partner":"7e8z" + "partner":"4ie0" }, { "sim":50.0, @@ -923634,6 +927389,10 @@ "sim":50.0, "partner":"4qho" }, + { + "sim":50.0, + "partner":"4ie7" + }, { "sim":50.0, "partner":"6rim" @@ -923678,14 +927437,6 @@ "sim":50.0, "partner":"3n6r" }, - { - "sim":50.0, - "partner":"8aq3" - }, - { - "sim":50.0, - "partner":"8aq4" - }, { "sim":50.0, "partner":"7aci" @@ -923694,10 +927445,6 @@ "sim":50.0, "partner":"8b0k" }, - { - "sim":50.0, - "partner":"5n6h" - }, { "sim":50.0, "partner":"8b0l" @@ -923710,6 +927457,10 @@ "sim":50.0, "partner":"8b0n" }, + { + "sim":50.0, + "partner":"5n6h" + }, { "sim":50.0, "partner":"8b0o" @@ -923726,6 +927477,14 @@ "sim":50.0, "partner":"5n6l" }, + { + "sim":50.0, + "partner":"8aq3" + }, + { + "sim":50.0, + "partner":"8aq4" + }, { "sim":50.0, "partner":"7lha" @@ -923780,7 +927539,7 @@ }, { "sim":50.0, - "partner":"5m12" + "partner":"6gwg" }, { "sim":50.0, @@ -923788,31 +927547,31 @@ }, { "sim":50.0, - "partner":"6gwf" + "partner":"6gta" }, { "sim":50.0, - "partner":"6gwg" + "partner":"5m16" }, { "sim":50.0, - "partner":"5m16" + "partner":"6gvd" }, { "sim":50.0, - "partner":"6gta" + "partner":"5m0x" }, { "sim":50.0, - "partner":"6gvd" + "partner":"6gx8" }, { "sim":50.0, - "partner":"5m0x" + "partner":"5m12" }, { "sim":50.0, - "partner":"6gx8" + "partner":"6gwf" }, { "sim":50.0, @@ -923866,18 +927625,6 @@ "sim":50.0, "partner":"3vsn" }, - { - "sim":50.0, - "partner":"4b73" - }, - { - "sim":50.0, - "partner":"4b74" - }, - { - "sim":50.0, - "partner":"5fpy" - }, { "sim":50.0, "partner":"4b75" @@ -923920,7 +927667,15 @@ }, { "sim":50.0, - "partner":"7w1c" + "partner":"4b73" + }, + { + "sim":50.0, + "partner":"4b74" + }, + { + "sim":50.0, + "partner":"5fpy" }, { "sim":50.0, @@ -923930,6 +927685,10 @@ "sim":50.0, "partner":"7w1e" }, + { + "sim":50.0, + "partner":"7w1c" + }, { "sim":50.0, "partner":"4b6e" @@ -923962,10 +927721,6 @@ "sim":50.0, "partner":"5ir5" }, - { - "sim":50.0, - "partner":"6k8s" - }, { "sim":50.0, "partner":"6k8t" @@ -923976,15 +927731,15 @@ }, { "sim":50.0, - "partner":"5y9d" + "partner":"6k8s" }, { "sim":50.0, - "partner":"5ux7" + "partner":"5y9d" }, { "sim":50.0, - "partner":"3rsz" + "partner":"5ux7" }, { "sim":50.0, @@ -924014,6 +927769,10 @@ "sim":50.0, "partner":"3nch" }, + { + "sim":50.0, + "partner":"3rsz" + }, { "sim":50.0, "partner":"8eax" @@ -924042,17 +927801,13 @@ "sim":50.0, "partner":"7p1g" }, - { - "sim":50.0, - "partner":"3l7r" - }, { "sim":50.0, "partner":"3t0c" }, { "sim":50.0, - "partner":"6edw" + "partner":"3l7r" }, { "sim":50.0, @@ -924064,23 +927819,15 @@ }, { "sim":50.0, - "partner":"8bou" - }, - { - "sim":50.0, - "partner":"7p1h" - }, - { - "sim":50.0, - "partner":"3ahc" + "partner":"6edw" }, { "sim":50.0, - "partner":"3ahd" + "partner":"8bou" }, { "sim":50.0, - "partner":"3ahe" + "partner":"7p1h" }, { "sim":50.0, @@ -924104,15 +927851,19 @@ }, { "sim":50.0, - "partner":"7jvi" + "partner":"3ahc" }, { "sim":50.0, - "partner":"4j3t" + "partner":"3ahd" }, { "sim":50.0, - "partner":"4j3u" + "partner":"3ahe" + }, + { + "sim":50.0, + "partner":"7jvi" }, { "sim":50.0, @@ -924132,7 +927883,11 @@ }, { "sim":50.0, - "partner":"5y1h" + "partner":"4j3t" + }, + { + "sim":50.0, + "partner":"4j3u" }, { "sim":50.0, @@ -924180,11 +927935,11 @@ }, { "sim":50.0, - "partner":"7s6b" + "partner":"5y1h" }, { "sim":50.0, - "partner":"7o3m" + "partner":"7s6b" }, { "sim":50.0, @@ -924193,6 +927948,10 @@ { "sim":50.0, "partner":"7o3l" + }, + { + "sim":50.0, + "partner":"7o3m" } ], "struct_thr_sim_designed":[ @@ -924221,7 +927980,7 @@ ], "seq_max_sim_designed":{ "sim":504.0, - "partner":"8v2w" + "partner":"8v09" }, "seq_max_sim_natural":{ "sim":407.0, @@ -924400,112 +928159,112 @@ ], "subtitle":"Computational designed nanocage o43_129_+4", "tags":[ + "de novo", "de novo protein", + "o43", "nanocage", - "de novo", - "programmable design", - "o43" + "programmable design" ], "keywords":[ "largely", - "oligomers", - "many", + "regularity", + "specified", + "number", + "owing", + "well", + "nested", + "wooden", + "protein", + "readily", + "linear", + "electron", + "blueprinted", + "microscopy", + "straightforward", + "house", + "circular", + "multicomponent", + "standards", + "secondary", + "envelope", + "using", + "placement", + "geometric", + "construction", + "complex", + "enables", "conform", - "inherit", + "backbones", + "comparison", + "enabling", + "polygonal", + "surfaces", + "track", + "blocks", "modules", - "crystallography", - "extendable", - "designed", - "geometries", - "deliberate", - "curved", + "large", "shapes", - "envelope", - "irregular", - "geometric", + "deliberate", + "pieces", + "1", + "geometries", + "consists", "blueprints", - "interactions", - "validate", - "structure", - "owing", - "building", + "design", + "onto", "principles", - "backbones", - "interaction", - "extendability", - "enables", - "straightforward", - "house", - "linear", - "angled", - "number", - "simple", + "expanded", + "simplicity", "geometrical", - "wooden", - "concentrically", - "relationships", - "onto", - "structures", - "nanomaterial", - "complexity", - "pieces", - "polygonal", - "circular", - "unbounded", - "much", + "simple", + "possible", + "different", + "sizes", "platform", - "previously", + "straight", + "architectural", "nanocages", - "polyhedral", - "regularity", - "specified", - "large", - "nested", + "complexity", + "relationships", + "build", + "validate", + "extendability", + "lumber", + "interaction", + "varying", + "nanomaterials", + "building", + "describe", "assemblies", + "designed", + "reinforced", + "concentrically", + "contracted", + "nanomaterial", + "curved", + "many", + "unbounded", + "structures", "ranging", - "1", - "lumber", - "surfaces", + "reconfigurable", + "polyhedral", + "oligomers", + "previously", + "structure", + "extendable", + "frame", "according", - "straight", + "irregular", + "crystallography", + "interactions", + "angled", + "regular", "blank", - "blocks", - "comparison", - "design", + "much", "canvas", - "using", - "secondary", - "describe", - "nanomaterials", - "architectural", - "reinforced", - "enabling", - "multicomponent", + "struts", "designs", - "build", - "construction", - "track", - "placement", - "sizes", - "electron", - "well", - "different", - "contracted", - "protein", - "regular", - "microscopy", - "frame", - "standards", - "complex", - "reconfigurable", - "readily", - "blueprinted", - "varying", - "consists", - "simplicity", - "possible", - "expanded", - "struts" + "inherit" ], "release_date":"2024-03-13", "publication":"\"Blueprinting extendable nanomaterials with standardized protein blocks\", Nature, 627, 898-904", @@ -924540,18 +928299,6 @@ "sim":571.0, "partner":"8v2d" }, - { - "sim":83.0, - "partner":"8ure" - }, - { - "sim":61.0, - "partner":"7ue2" - }, - { - "sim":54.0, - "partner":"8f6r" - }, { "sim":241.0, "partner":"8e0l" @@ -924622,15 +928369,27 @@ }, { "sim":52.0, - "partner":"7udm" + "partner":"7udn" }, { "sim":52.0, - "partner":"7udn" + "partner":"7udm" }, { "sim":51.0, "partner":"8fit" + }, + { + "sim":83.0, + "partner":"8ure" + }, + { + "sim":61.0, + "partner":"7ue2" + }, + { + "sim":54.0, + "partner":"8f6r" } ], "seq_thr_sim_natural":[ @@ -924721,105 +928480,105 @@ ], "subtitle":"Imaging scaffold engineered to bind the therapeutic protein target bard1", "tags":[ - "nanohedra", - "imaging scaffold", - "protein cage", - "de novo protein", "tetrahedral", - "darpin" + "darpin", + "de novo protein", + "protein cage", + "imaging scaffold", + "nanohedra" ], "keywords":[ + "structural", + "resolution", + "repeat", + "well", + "three", + "via", + "unusually", "results", - "thus", - "imaging", - "suggest", - "scaffolds", - "crystallography", - "determination", - "designed", - "lattice", - "determine", - "towards", - "crystal", - "potential", - "findings", - "structure", + "vertices", + "ligands", + "complements", + "protein", + "electron", + "binding", "representative", - "repeat", - "alternative", - "porous", - "utility", + "microscopy", + "investigations", + "b", + "apo", "composed", - "cargo", - "suggesting", - "proteins", - "\u00e5", + "channel", + "recent", + "related", + "crystal", + "applications", + "possibility", + "alternative", "characterized", - "kda", - "small", - "serve", - "complements", - "symmetric", - "particularly", - "repurposed", "oriented", - "structures", - "vertices", - "assembly", - "three", - "biology", - "ligands", - "solvent", - "unusually", + "determination", + "thus", + "particularly", + "enabled", + "cargo", + "positioned", + "fused", "adaptors", - "reported", + "tetrahedral", + "proteins", "large", - "via", - "resolution", - "darpins", - "vertex", - "fused", + "ankyrin", + "modular", "may", - "closely", - "cages", - "apo", + "scaffold", + "small", + "soak", + "suggest", + "suggesting", + "subunits", + "24", "12", - "observed", + "diverse", + "biology", + "possible", + "potential", + "assembly", + "porous", + "cryogenic", + "also", "type", - "crystallographic", - "positioned", + "kda", + "symmetric", + "cages", + "utility", + "reported", + "crystals", "present", - "applications", - "recent", - "subunits", - "structural", - "diverse", - "designs", + "determine", + "repurposed", + "crystallographic", + "darpins", + "designed", + "extending", "one", - "also", - "possibility", - "channel", - "electron", - "well", - "modular", - "ankyrin", - "soak", + "observed", + "structures", + "vertex", + "imaging", + "\u00e5", + "structure", + "scaffolds", + "serve", "subsequently", + "closely", + "findings", + "crystallography", "state", - "24", - "scaffold", - "b", - "protein", - "microscopy", - "tetrahedral", - "investigations", - "enabled", - "extending", - "possible", - "binding", - "cryogenic", - "related", - "crystals" + "towards", + "lattice", + "solvent", + "designs" ], "release_date":"2024-05-15", "publication":"\"X-ray crystal structure of a designed rigidified imaging scaffold in the ligand-free conformation\", Acta Crystallogr.,Sect.F, 80, 107-115", @@ -924858,10 +928617,6 @@ "sim":301.0, "partner":"8ve7" }, - { - "sim":231.0, - "partner":"8vdz" - }, { "sim":254.0, "partner":"6fp9" @@ -924888,11 +928643,11 @@ }, { "sim":244.0, - "partner":"7z71" + "partner":"7z7e" }, { "sim":244.0, - "partner":"7z7e" + "partner":"7z71" }, { "sim":244.0, @@ -924960,11 +928715,11 @@ }, { "sim":232.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":232.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":231.0, @@ -924980,19 +928735,19 @@ }, { "sim":230.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":230.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":230.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":230.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":230.0, @@ -925000,35 +928755,35 @@ }, { "sim":230.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":230.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":230.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":230.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":230.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":230.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":230.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":230.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":229.0, @@ -925072,11 +928827,11 @@ }, { "sim":224.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":224.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":224.0, @@ -925088,7 +928843,7 @@ }, { "sim":223.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":223.0, @@ -925096,7 +928851,7 @@ }, { "sim":223.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":222.0, @@ -925168,11 +928923,11 @@ }, { "sim":183.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":183.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":180.0, @@ -925202,6 +928957,10 @@ "sim":169.0, "partner":"5hs0" }, + { + "sim":167.0, + "partner":"9glq" + }, { "sim":167.0, "partner":"2jab" @@ -925221,16 +928980,100 @@ { "sim":81.0, "partner":"8fre" + }, + { + "sim":231.0, + "partner":"8vdz" } ], "seq_thr_sim_natural":[ + { + "sim":573.0, + "partner":"8g3k" + }, + { + "sim":337.0, + "partner":"5cy5" + }, + { + "sim":311.0, + "partner":"1wy1" + }, + { + "sim":299.0, + "partner":"4nwp" + }, + { + "sim":299.0, + "partner":"4nwq" + }, + { + "sim":320.0, + "partner":"6nht" + }, + { + "sim":320.0, + "partner":"6nhv" + }, + { + "sim":281.0, + "partner":"6c9i" + }, + { + "sim":240.0, + "partner":"6x1i" + }, + { + "sim":110.0, + "partner":"1wvt" + }, + { + "sim":298.0, + "partner":"5vl4" + }, + { + "sim":103.0, + "partner":"2ah6" + }, + { + "sim":293.0, + "partner":"1nog" + }, + { + "sim":94.0, + "partner":"3gaj" + }, + { + "sim":94.0, + "partner":"3ci1" + }, + { + "sim":94.0, + "partner":"3ci3" + }, + { + "sim":94.0, + "partner":"3ci4" + }, + { + "sim":93.0, + "partner":"2r6t" + }, + { + "sim":93.0, + "partner":"2nt8" + }, { "sim":576.0, "partner":"8g4e" }, { - "sim":573.0, - "partner":"8g4f" + "sim":91.0, + "partner":"3gah" + }, + { + "sim":91.0, + "partner":"2r6x" }, { "sim":573.0, @@ -925246,35 +929089,59 @@ }, { "sim":573.0, - "partner":"8g3k" + "partner":"8g4f" }, { - "sim":320.0, - "partner":"6nht" + "sim":90.0, + "partner":"3gai" }, { - "sim":320.0, - "partner":"6nhv" + "sim":98.0, + "partner":"3ke4" }, { - "sim":337.0, - "partner":"5cy5" + "sim":98.0, + "partner":"3ke5" }, { - "sim":298.0, - "partner":"5vl4" + "sim":108.0, + "partner":"1rty" }, { - "sim":293.0, - "partner":"1nog" + "sim":153.0, + "partner":"1woz" }, { - "sim":254.0, - "partner":"6fp7" + "sim":88.0, + "partner":"2zhy" }, { - "sim":254.0, - "partner":"6fp8" + "sim":88.0, + "partner":"2zhz" + }, + { + "sim":85.0, + "partner":"6d5x" + }, + { + "sim":85.0, + "partner":"6d5k" + }, + { + "sim":85.0, + "partner":"2idx" + }, + { + "sim":84.0, + "partner":"7ruv" + }, + { + "sim":82.0, + "partner":"7rut" + }, + { + "sim":82.0, + "partner":"7ruu" }, { "sim":248.0, @@ -925284,6 +929151,42 @@ "sim":248.0, "partner":"8dmi" }, + { + "sim":85.0, + "partner":"5im6" + }, + { + "sim":76.0, + "partner":"8d32" + }, + { + "sim":76.0, + "partner":"2g2d" + }, + { + "sim":76.0, + "partner":"6wgs" + }, + { + "sim":76.0, + "partner":"6wgu" + }, + { + "sim":76.0, + "partner":"6wgv" + }, + { + "sim":76.0, + "partner":"6wh5" + }, + { + "sim":254.0, + "partner":"6fp7" + }, + { + "sim":254.0, + "partner":"6fp8" + }, { "sim":247.0, "partner":"4hrm" @@ -925326,11 +929229,11 @@ }, { "sim":242.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":242.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":242.0, @@ -925364,10 +929267,6 @@ "sim":239.0, "partner":"5o2s" }, - { - "sim":239.0, - "partner":"8tzb" - }, { "sim":239.0, "partner":"8tzc" @@ -925384,6 +929283,10 @@ "sim":239.0, "partner":"8tzh" }, + { + "sim":239.0, + "partner":"8tzb" + }, { "sim":238.0, "partner":"5op1" @@ -925410,19 +929313,19 @@ }, { "sim":237.0, - "partner":"4k5b" + "partner":"6d65" }, { "sim":237.0, - "partner":"6d65" + "partner":"4k5b" }, { "sim":237.0, - "partner":"4jb8" + "partner":"5mbm" }, { "sim":237.0, - "partner":"5mbm" + "partner":"4jb8" }, { "sim":237.0, @@ -925450,11 +929353,11 @@ }, { "sim":234.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":234.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":234.0, @@ -925472,45 +929375,25 @@ "sim":233.0, "partner":"5aq9" }, - { - "sim":232.0, - "partner":"5eno" - }, - { - "sim":232.0, - "partner":"6zob" - }, - { - "sim":232.0, - "partner":"6zo5" - }, { "sim":232.0, "partner":"4dx6" }, { "sim":232.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":232.0, "partner":"6zoc" }, - { - "sim":232.0, - "partner":"5enp" - }, - { - "sim":232.0, - "partner":"6sgs" - }, { "sim":232.0, "partner":"6zo6" }, { "sim":232.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":232.0, @@ -925518,7 +929401,7 @@ }, { "sim":232.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":232.0, @@ -925526,11 +929409,11 @@ }, { "sim":232.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":232.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":232.0, @@ -925540,6 +929423,10 @@ "sim":232.0, "partner":"6zoe" }, + { + "sim":232.0, + "partner":"5enq" + }, { "sim":232.0, "partner":"6q4p" @@ -925550,19 +929437,19 @@ }, { "sim":232.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":232.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":232.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":232.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":232.0, @@ -925574,23 +929461,23 @@ }, { "sim":232.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":232.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":232.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":232.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":232.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":232.0, @@ -925602,15 +929489,15 @@ }, { "sim":232.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":232.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":232.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":232.0, @@ -925618,15 +929505,19 @@ }, { "sim":232.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":232.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":232.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":232.0, + "partner":"6sgr" }, { "sim":232.0, @@ -925642,12 +929533,24 @@ }, { "sim":232.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":232.0, "partner":"4dx5" }, + { + "sim":232.0, + "partner":"5eno" + }, + { + "sim":232.0, + "partner":"6zo5" + }, + { + "sim":232.0, + "partner":"6q4n" + }, { "sim":232.0, "partner":"6z4s" @@ -925712,30 +929615,18 @@ "sim":230.0, "partner":"6bbn" }, - { - "sim":230.0, - "partner":"7yz0" - }, { "sim":230.0, "partner":"6mzf" }, { "sim":230.0, - "partner":"7yz1" - }, - { - "sim":230.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":230.0, "partner":"5nqt" }, - { - "sim":230.0, - "partner":"6mze" - }, { "sim":230.0, "partner":"7yz2" @@ -925746,11 +929637,11 @@ }, { "sim":230.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":230.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":230.0, @@ -925762,11 +929653,11 @@ }, { "sim":230.0, - "partner":"4lnu" + "partner":"7yz6" }, { "sim":230.0, - "partner":"7yz6" + "partner":"4lnu" }, { "sim":230.0, @@ -925778,19 +929669,19 @@ }, { "sim":230.0, - "partner":"4drx" + "partner":"6zwb" }, { "sim":230.0, - "partner":"5eib" + "partner":"4drx" }, { "sim":230.0, - "partner":"5nm5" + "partner":"5eib" }, { "sim":230.0, - "partner":"6zwb" + "partner":"5nm5" }, { "sim":230.0, @@ -925804,6 +929695,18 @@ "sim":230.0, "partner":"7yyz" }, + { + "sim":230.0, + "partner":"7yz0" + }, + { + "sim":230.0, + "partner":"7yz1" + }, + { + "sim":230.0, + "partner":"7z01" + }, { "sim":230.0, "partner":"5mla" @@ -925826,11 +929729,11 @@ }, { "sim":229.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":229.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":229.0, @@ -925958,11 +929861,11 @@ }, { "sim":211.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":211.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":210.0, @@ -925982,11 +929885,11 @@ }, { "sim":204.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":204.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":199.0, @@ -925996,10 +929899,6 @@ "sim":198.0, "partner":"6moi" }, - { - "sim":190.0, - "partner":"7pd8" - }, { "sim":190.0, "partner":"7pdd" @@ -926012,6 +929911,10 @@ "sim":190.0, "partner":"7pdh" }, + { + "sim":190.0, + "partner":"7pd8" + }, { "sim":186.0, "partner":"6mzg" @@ -926062,15 +929965,15 @@ }, { "sim":169.0, - "partner":"6d66" + "partner":"2xzd" }, { "sim":169.0, - "partner":"6d67" + "partner":"6d66" }, { "sim":169.0, - "partner":"2xzd" + "partner":"6d67" }, { "sim":168.0, @@ -926100,10 +930003,6 @@ "sim":155.0, "partner":"6ne2" }, - { - "sim":153.0, - "partner":"1woz" - }, { "sim":153.0, "partner":"6ne4" @@ -926162,23 +930061,23 @@ }, { "sim":121.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":121.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":121.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":121.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":121.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":121.0, @@ -926186,11 +930085,11 @@ }, { "sim":121.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":121.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":121.0, @@ -926256,18 +930155,10 @@ "sim":109.0, "partner":"5vkq" }, - { - "sim":108.0, - "partner":"1rty" - }, { "sim":108.0, "partner":"7uzq" }, - { - "sim":108.0, - "partner":"5vhj" - }, { "sim":108.0, "partner":"5vhh" @@ -926298,15 +930189,15 @@ }, { "sim":108.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":108.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":108.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":108.0, @@ -926316,6 +930207,10 @@ "sim":108.0, "partner":"7vxw" }, + { + "sim":108.0, + "partner":"1uoh" + }, { "sim":108.0, "partner":"7vy4" @@ -926326,11 +930221,11 @@ }, { "sim":108.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":108.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":108.0, @@ -926378,20 +930273,16 @@ }, { "sim":105.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":105.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":104.0, "partner":"4b93" }, - { - "sim":103.0, - "partner":"2ah6" - }, { "sim":102.0, "partner":"6by9" @@ -926444,18 +930335,6 @@ "sim":99.0, "partner":"8wfz" }, - { - "sim":311.0, - "partner":"1wy1" - }, - { - "sim":98.0, - "partner":"3ke4" - }, - { - "sim":98.0, - "partner":"3ke5" - }, { "sim":96.0, "partner":"6xkc" @@ -926498,11 +930377,11 @@ }, { "sim":96.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":96.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":95.0, @@ -926536,14 +930415,6 @@ "sim":94.0, "partner":"1mx2" }, - { - "sim":299.0, - "partner":"4nwp" - }, - { - "sim":299.0, - "partner":"4nwq" - }, { "sim":94.0, "partner":"7t4x" @@ -926594,16 +930465,24 @@ }, { "sim":93.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":93.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":93.0, "partner":"7roy" }, + { + "sim":93.0, + "partner":"8wqg" + }, + { + "sim":93.0, + "partner":"8wqe" + }, { "sim":93.0, "partner":"8wqh" @@ -926632,14 +930511,6 @@ "sim":93.0, "partner":"8wqd" }, - { - "sim":93.0, - "partner":"8wqg" - }, - { - "sim":93.0, - "partner":"8wqe" - }, { "sim":93.0, "partner":"8je1" @@ -926652,10 +930523,6 @@ "sim":93.0, "partner":"8je2" }, - { - "sim":281.0, - "partner":"6c9i" - }, { "sim":92.0, "partner":"5aar" @@ -926684,10 +930551,6 @@ "sim":90.0, "partner":"1mx6" }, - { - "sim":110.0, - "partner":"1wvt" - }, { "sim":89.0, "partner":"3v30" @@ -926700,26 +930563,6 @@ "sim":89.0, "partner":"3uxg" }, - { - "sim":94.0, - "partner":"3gaj" - }, - { - "sim":94.0, - "partner":"3ci1" - }, - { - "sim":94.0, - "partner":"3ci3" - }, - { - "sim":94.0, - "partner":"3ci4" - }, - { - "sim":93.0, - "partner":"2r6t" - }, { "sim":89.0, "partner":"1nfi" @@ -926748,26 +930591,10 @@ "sim":89.0, "partner":"7pty" }, - { - "sim":88.0, - "partner":"2zhy" - }, - { - "sim":88.0, - "partner":"2zhz" - }, - { - "sim":93.0, - "partner":"2nt8" - }, { "sim":87.0, "partner":"5ja4" }, - { - "sim":91.0, - "partner":"2r6x" - }, { "sim":87.0, "partner":"6jd6" @@ -926780,18 +930607,6 @@ "sim":87.0, "partner":"5et0" }, - { - "sim":91.0, - "partner":"3gah" - }, - { - "sim":85.0, - "partner":"5im6" - }, - { - "sim":90.0, - "partner":"3gai" - }, { "sim":85.0, "partner":"2qc9" @@ -926856,10 +930671,6 @@ "sim":83.0, "partner":"1s70" }, - { - "sim":83.0, - "partner":"6v9x" - }, { "sim":83.0, "partner":"6v9y" @@ -926872,6 +930683,10 @@ "sim":83.0, "partner":"6v9w" }, + { + "sim":83.0, + "partner":"6v9x" + }, { "sim":83.0, "partner":"7or0" @@ -926938,19 +930753,19 @@ }, { "sim":81.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":81.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":81.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":81.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":81.0, @@ -927012,10 +930827,6 @@ "sim":80.0, "partner":"5ybe" }, - { - "sim":240.0, - "partner":"6x1i" - }, { "sim":79.0, "partner":"6kyh" @@ -927028,18 +930839,6 @@ "sim":78.0, "partner":"1bi7" }, - { - "sim":85.0, - "partner":"6d5x" - }, - { - "sim":85.0, - "partner":"6d5k" - }, - { - "sim":85.0, - "partner":"2idx" - }, { "sim":78.0, "partner":"2he0" @@ -927062,40 +930861,12 @@ }, { "sim":76.0, - "partner":"8d32" - }, - { - "sim":76.0, - "partner":"2g2d" - }, - { - "sim":76.0, - "partner":"6wh5" - }, - { - "sim":76.0, - "partner":"6wgs" - }, - { - "sim":76.0, - "partner":"6wgu" - }, - { - "sim":76.0, - "partner":"6wgv" - }, - { - "sim":84.0, - "partner":"7ruv" + "partner":"1k1b" }, { "sim":76.0, "partner":"1k1a" }, - { - "sim":76.0, - "partner":"1k1b" - }, { "sim":76.0, "partner":"7xbk" @@ -927104,29 +930875,21 @@ "sim":75.0, "partner":"8fds" }, - { - "sim":82.0, - "partner":"7rut" - }, - { - "sim":82.0, - "partner":"7ruu" - }, { "sim":74.0, "partner":"1d9s" }, { "sim":74.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":74.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":74.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":74.0, @@ -927138,11 +930901,11 @@ }, { "sim":73.0, - "partner":"5z2n" + "partner":"8pef" }, { "sim":73.0, - "partner":"8pef" + "partner":"5z2n" }, { "sim":73.0, @@ -927168,10 +930931,6 @@ "sim":72.0, "partner":"5wo6" }, - { - "sim":72.0, - "partner":"5iwr" - }, { "sim":72.0, "partner":"5iwt" @@ -927224,6 +930983,10 @@ "sim":72.0, "partner":"5iwp" }, + { + "sim":72.0, + "partner":"5iwr" + }, { "sim":72.0, "partner":"5wo7" @@ -927248,10 +931011,6 @@ "sim":70.0, "partner":"6e2g" }, - { - "sim":68.0, - "partner":"6o1p" - }, { "sim":68.0, "partner":"6b5v" @@ -927290,11 +931049,7 @@ }, { "sim":68.0, - "partner":"7t6m" - }, - { - "sim":68.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":68.0, @@ -927330,15 +931085,19 @@ }, { "sim":68.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":68.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":68.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":68.0, + "partner":"7t6k" }, { "sim":68.0, @@ -927346,7 +931105,7 @@ }, { "sim":68.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":68.0, @@ -927354,7 +931113,11 @@ }, { "sim":68.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":68.0, + "partner":"8ffn" }, { "sim":68.0, @@ -927382,11 +931145,11 @@ }, { "sim":65.0, - "partner":"6tlh" + "partner":"6tmd" }, { "sim":65.0, - "partner":"6tmd" + "partner":"6tlh" }, { "sim":65.0, @@ -927440,21 +931203,17 @@ "sim":63.0, "partner":"7us2" }, - { - "sim":63.0, - "partner":"7ttr" - }, { "sim":63.0, "partner":"7tts" }, { "sim":63.0, - "partner":"8sp8" + "partner":"7ttr" }, { "sim":63.0, - "partner":"7k4a" + "partner":"8sp8" }, { "sim":63.0, @@ -927478,7 +931237,7 @@ }, { "sim":63.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":63.0, @@ -927494,7 +931253,7 @@ }, { "sim":63.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":63.0, @@ -927506,7 +931265,7 @@ }, { "sim":63.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":63.0, @@ -927524,6 +931283,10 @@ "sim":63.0, "partner":"6bo8" }, + { + "sim":63.0, + "partner":"6bo9" + }, { "sim":62.0, "partner":"8deh" @@ -927558,19 +931321,19 @@ }, { "sim":60.0, - "partner":"8u43" + "partner":"8u2z" }, { "sim":60.0, - "partner":"8u4d" + "partner":"8u43" }, { "sim":60.0, - "partner":"8u3a" + "partner":"8u4d" }, { "sim":60.0, - "partner":"8u2z" + "partner":"8u3a" }, { "sim":60.0, @@ -927584,18 +931347,10 @@ "sim":60.0, "partner":"5is0" }, - { - "sim":60.0, - "partner":"7mzc" - }, { "sim":60.0, "partner":"7l2v" }, - { - "sim":60.0, - "partner":"8t3l" - }, { "sim":60.0, "partner":"7mzd" @@ -927606,7 +931361,7 @@ }, { "sim":60.0, - "partner":"8t3m" + "partner":"8t3l" }, { "sim":60.0, @@ -927624,6 +931379,10 @@ "sim":60.0, "partner":"7l2x" }, + { + "sim":60.0, + "partner":"8t3m" + }, { "sim":60.0, "partner":"7l2r" @@ -927658,35 +931417,35 @@ }, { "sim":60.0, - "partner":"8t0y" + "partner":"7mzc" }, { "sim":60.0, - "partner":"8u3l" + "partner":"8t0y" }, { "sim":60.0, - "partner":"8t0c" + "partner":"8u30" }, { "sim":60.0, - "partner":"8u30" + "partner":"8u3c" }, { "sim":60.0, - "partner":"8t0e" + "partner":"8t0c" }, { "sim":60.0, - "partner":"8t10" + "partner":"8t0e" }, { "sim":60.0, - "partner":"8u3c" + "partner":"8t10" }, { "sim":60.0, - "partner":"7l2n" + "partner":"8u3l" }, { "sim":60.0, @@ -927722,20 +931481,16 @@ }, { "sim":60.0, - "partner":"7lpd" + "partner":"7l2n" }, { "sim":60.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":60.0, "partner":"7rqv" }, - { - "sim":60.0, - "partner":"7lpe" - }, { "sim":60.0, "partner":"7rqw" @@ -927768,6 +931523,14 @@ "sim":60.0, "partner":"7lpc" }, + { + "sim":60.0, + "partner":"7rqu" + }, + { + "sim":60.0, + "partner":"7lpd" + }, { "sim":59.0, "partner":"6l93" @@ -927796,6 +931559,10 @@ "sim":58.0, "partner":"4a63" }, + { + "sim":58.0, + "partner":"8ycp" + }, { "sim":58.0, "partner":"8gf8" @@ -927866,7 +931633,7 @@ }, { "sim":50.0, - "partner":"8gkg" + "partner":"8gka" }, { "sim":50.0, @@ -927874,11 +931641,7 @@ }, { "sim":50.0, - "partner":"8gka" - }, - { - "sim":50.0, - "partner":"6dvz" + "partner":"8gkg" }, { "sim":50.0, @@ -927890,19 +931653,11 @@ }, { "sim":50.0, - "partner":"6pvo" - }, - { - "sim":50.0, - "partner":"7mij" - }, - { - "sim":50.0, - "partner":"6pvp" + "partner":"6dvz" }, { "sim":50.0, - "partner":"7ras" + "partner":"6pvq" }, { "sim":50.0, @@ -927910,7 +931665,7 @@ }, { "sim":50.0, - "partner":"6pvq" + "partner":"7ras" }, { "sim":50.0, @@ -927938,11 +931693,11 @@ }, { "sim":50.0, - "partner":"7min" + "partner":"6pvl" }, { "sim":50.0, - "partner":"6pvl" + "partner":"7min" }, { "sim":50.0, @@ -927950,15 +931705,15 @@ }, { "sim":50.0, - "partner":"7mio" + "partner":"6pvm" }, { "sim":50.0, - "partner":"7ugg" + "partner":"7mio" }, { "sim":50.0, - "partner":"6pvm" + "partner":"7ugg" }, { "sim":50.0, @@ -927970,7 +931725,15 @@ }, { "sim":50.0, - "partner":"6mhw" + "partner":"6pvo" + }, + { + "sim":50.0, + "partner":"6pvp" + }, + { + "sim":50.0, + "partner":"7mij" }, { "sim":50.0, @@ -927988,6 +931751,10 @@ "sim":50.0, "partner":"6mhv" }, + { + "sim":50.0, + "partner":"6mhw" + }, { "sim":50.0, "partner":"7xj0" @@ -928147,77 +931914,77 @@ ], "subtitle":"Crystal structure of heme-loaded design: hem_3.c9", "tags":[ - "rosettafold", - "alphafold2", - "de novo protein", "rfdiffusion", - "de novo design" + "de novo design", + "alphafold2", + "rosettafold", + "de novo protein" ], "keywords":[ - "covalent", - "rosettafold", - "builds", + "measurements", + "rfaa", + "designed", + "digoxigenin", + "molecule", + "surrounding", "disease", - "revolutionized", + "limited", + "design", + "sequences", + "atomic", + "methods", "distributions", - "amino", - "groups", - "proteins", - "surrounding", - "nucleic", - "rfdiffusion", - "digoxigenin", + "structures", + "starting", + "metals", + "around", + "presently", + "experimentally", "dna", - "assemblies", - "chemical", - "random", - "rfdiffusionaa", - "cofactor", - "molecule", - "acid", - "crystallography", + "representation", "enzymatic", + "residues", + "structure", + "acid", "heme", - "acids", - "designed", - "bases", - "cardiac", - "bilin", "prediction", - "presently", - "small", - "residues", - "tasks", - "rfaa", - "methods", - "modifications", - "experimentally", - "validated", - "limited", - "target", - "design", + "groups", + "cardiac", "model", - "metals", - "sequences", - "structures", + "target", + "crystallography", + "covalent", + "therapeutic", "protein", - "binding", + "nucleic", "bind", + "amino", + "rfdiffusion", + "rosettafold", + "modifications", + "proteins", "given", - "atomic", - "structure", - "describe", - "denoising", - "representation", - "combines", - "measurements", - "therapeutic", + "random", + "binding", "molecules", + "revolutionized", + "validated", + "builds", + "small", + "bilin", "systems", - "around", + "acids", + "contain", + "tasks", "developed", - "starting", - "contain" + "combines", + "denoising", + "chemical", + "describe", + "assemblies", + "cofactor", + "bases", + "rfdiffusionaa" ], "release_date":"2024-03-20", "publication":"\"Generalized biomolecular modeling and design with RoseTTAFold All-Atom\", Science, 384, eadl2528-eadl2528", @@ -928378,98 +932145,98 @@ ], "subtitle":"Crystal structure of cap repeat", "tags":[ - "sequence", - "generation", + "proteingenerator", + "machine learning", + "de novo", "rosettafold", + "de novo protein", + "generation", + "diffusion", "generative model", - "machine learning", - "proteingenerator", "deep learning", - "de novo protein", - "de novo", "protein generator", - "diffusion" + "sequence" ], "keywords":[ - "beginning", - "constraints", - "intact", - "providing", - "acid", - "designed", - "probabilistic", - "trajectories", + "repeats", "limited", - "based", - "sequences", + "triples", + "structural", "overcome", - "generates", - "split", - "structure", - "denoising", - "compositions", - "limitation", - "backbones", "thermostable", - "general", - "models", - "proteins", - "de", - "multistate", - "child", - "used", - "ability", - "structures", - "versus", - "pairs", - "function", - "averaging", + "experimental", + "probabilistic", "simultaneously", - "properties", - "generation", + "acid", + "model", + "protein", + "rosettafold", + "child", + "limitation", + "guided", + "trajectories", + "novo", + "general", + "pg", + "domains", + "split", + "bioactive", "parent", - "data", - "functional", - "guide", - "amino", - "cage", + "two", + "backbones", + "supersecondary", + "integrated", "optimization", + "approach", + "proteins", + "compositions", + "constraints", + "cage", "noised", - "design", - "model", "iterative", - "diffusion", - "sequence", - "repeats", + "computational", + "pairs", + "design", + "used", + "functional", + "different", "representation", + "properties", + "amino", + "generates", + "varying", + "ability", + "multistate", + "sequence", + "peptides", + "developed", + "versus", "melittin", - "structural", - "guided", - "bioactive", - "rosettafold", - "logits", - "approach", - "novo", "desired", - "experimental", - "proteingenerator", - "peptides", - "pg", - "different", - "supersecondary", - "two", "folds", - "domains", - "integrated", - "triples", - "protein", + "designed", + "models", + "generation", + "sequences", + "beginning", + "logits", "space", + "providing", + "structures", + "de", + "proteingenerator", + "based", + "structure", + "intact", + "function", + "internal", "attributes", - "varying", "distinct", - "computational", - "internal", - "developed" + "guide", + "denoising", + "data", + "diffusion", + "averaging" ], "release_date":"2024-09-18", "publication":"\"Multistate and functional protein design using RoseTTAFold sequence space diffusion\", Nat.Biotechnol.", @@ -928577,103 +932344,103 @@ ], "subtitle":"A designed tetrahedral protein scaffold - darp14", "tags":[ - "scaffold", - "symmetrical", - "de novo protein", "tetrahedral", - "darpin" + "darpin", + "de novo protein", + "symmetrical", + "scaffold" ], "keywords":[ - "many", - "possibly", - "use", - "complexes", - "designed", "allow", - "alignment", - "flexibility", - "improved", - "particles", - "constituent", - "target", - "increasingly", - "reconstruction", "overcome", - "regions", - "detrimental", - "structure", - "cryoem", - "resolve", - "applied", - "able", - "called", - "proteins", - "detail", - "outlined", - "thousands", - "\u00e5", - "feature", - "highly", - "difficult", - "fully", - "symmetric", - "signals", - "reconstruct", - "dynamic", - "function", - "signal", - "averaging", - "processing", - "first", - "data", - "obtained", - "additionally", + "complexes", "tetrahedrally", - "refinement", - "attachments", - "approaches", + "core", + "macromolecules", + "observable", + "new", + "particles", "aligned", + "protein", + "maps", + "fully", + "together", "region", - "protocol", - "advances", - "core", - "reduced", "secondary", + "focused", + "placement", + "flexibility", + "possibly", + "dynamic", + "attachments", + "able", + "final", "effect", + "protocol", "technique", - "symmetry", - "maps", - "subunits", - "techniques", - "pronounced", - "could", - "reconstructions", + "proteins", "inherently", - "vastly", - "variant", - "designs", - "averaged", - "final", + "use", + "blurring", + "scaffold", + "highly", + "darp14", + "subunits", + "reconstruct", + "regions", + "obtained", + "mitigating", + "advances", + "symmetry", "critical", - "applicable", - "placement", + "subtraction", + "feature", + "signals", + "thousands", + "processing", + "constituent", + "called", + "variant", "also", - "flexible", - "together", - "observable", - "focused", - "darpin", - "mitigating", "precisely", - "scaffold", - "subtraction", - "macromolecules", - "protein", + "cryoem", + "resolve", + "applicable", + "reduced", + "improved", + "symmetric", + "applied", + "detrimental", + "reconstructions", + "techniques", "full", - "blurring", - "darp14", + "refinement", + "could", + "designed", + "pronounced", + "many", + "vastly", + "reconstruction", + "approaches", + "first", + "darpin", + "\u00e5", + "structure", + "flexible", + "additionally", + "target", + "function", + "signal", "becoming", - "new" + "detail", + "difficult", + "increasingly", + "data", + "designs", + "averaged", + "alignment", + "outlined", + "averaging" ], "release_date":"2024-06-05", "publication":"\"Mitigating the Blurring Effect of CryoEM Averaging on a Flexible and Highly Symmetric Protein Complex through Sub-Particle Reconstruction\", Int J Mol Sci, 25", @@ -928720,11 +932487,11 @@ "seq_thr_sim_natural":[ { "sim":273.0, - "partner":"6nht" + "partner":"6c9i" }, { "sim":273.0, - "partner":"6c9i" + "partner":"6nht" }, { "sim":273.0, @@ -928766,10 +932533,6 @@ "sim":81.0, "partner":"2ah6" }, - { - "sim":81.0, - "partner":"8g4f" - }, { "sim":81.0, "partner":"8g42" @@ -928782,6 +932545,10 @@ "sim":81.0, "partner":"8g47" }, + { + "sim":81.0, + "partner":"8g4f" + }, { "sim":81.0, "partner":"8g4e" @@ -928898,10 +932665,6 @@ "sim":55.0, "partner":"2g2d" }, - { - "sim":55.0, - "partner":"6wh5" - }, { "sim":55.0, "partner":"6wgs" @@ -928913,6 +932676,10 @@ { "sim":55.0, "partner":"6wgv" + }, + { + "sim":55.0, + "partner":"6wh5" } ], "struct_thr_sim_designed":[ @@ -929015,103 +932782,103 @@ ], "subtitle":"A darpin displayed on a designed tetrahedral protein scaffold", "tags":[ - "scaffold", - "symmetrical", - "de novo protein", "tetrahedral", - "darpin" + "darpin", + "de novo protein", + "symmetrical", + "scaffold" ], "keywords":[ - "many", - "possibly", - "use", - "complexes", - "designed", "allow", - "alignment", - "flexibility", - "improved", - "particles", - "constituent", - "target", - "increasingly", - "reconstruction", "overcome", - "regions", - "detrimental", - "structure", - "cryoem", - "resolve", - "applied", - "able", - "called", - "proteins", - "detail", - "outlined", - "thousands", - "\u00e5", - "feature", - "highly", - "difficult", - "fully", - "symmetric", - "signals", - "reconstruct", - "dynamic", - "function", - "signal", - "averaging", - "processing", - "first", - "data", - "obtained", - "additionally", + "complexes", "tetrahedrally", - "refinement", - "attachments", - "approaches", + "core", + "macromolecules", + "observable", + "new", + "particles", "aligned", + "protein", + "maps", + "fully", + "together", "region", - "protocol", - "advances", - "core", - "reduced", "secondary", + "focused", + "placement", + "flexibility", + "possibly", + "dynamic", + "attachments", + "able", + "final", "effect", + "protocol", "technique", - "symmetry", - "maps", - "subunits", - "techniques", - "pronounced", - "could", - "reconstructions", + "proteins", "inherently", - "vastly", - "variant", - "designs", - "averaged", - "final", + "use", + "blurring", + "scaffold", + "highly", + "darp14", + "subunits", + "reconstruct", + "regions", + "obtained", + "mitigating", + "advances", + "symmetry", "critical", - "applicable", - "placement", + "subtraction", + "feature", + "signals", + "thousands", + "processing", + "constituent", + "called", + "variant", "also", - "flexible", - "together", - "observable", - "focused", - "darpin", - "mitigating", "precisely", - "scaffold", - "subtraction", - "macromolecules", - "protein", + "cryoem", + "resolve", + "applicable", + "reduced", + "improved", + "symmetric", + "applied", + "detrimental", + "reconstructions", + "techniques", "full", - "blurring", - "darp14", + "refinement", + "could", + "designed", + "pronounced", + "many", + "vastly", + "reconstruction", + "approaches", + "first", + "darpin", + "\u00e5", + "structure", + "flexible", + "additionally", + "target", + "function", + "signal", "becoming", - "new" + "detail", + "difficult", + "increasingly", + "data", + "designs", + "averaged", + "alignment", + "outlined", + "averaging" ], "release_date":"2024-06-05", "publication":"\"Mitigating the Blurring Effect of CryoEM Averaging on a Flexible and Highly Symmetric Protein Complex through Sub-Particle Reconstruction\", Int J Mol Sci, 25", @@ -929140,7 +932907,7 @@ "synthesis_comment":"", "review":true, "previous_design":"8vdz", - "next_design":"8vei", + "next_design":"8vea", "seq_thr_sim_designed":[ { "sim":583.0, @@ -929212,19 +932979,19 @@ }, { "sim":255.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":255.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":255.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":255.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":255.0, @@ -929232,35 +932999,35 @@ }, { "sim":255.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":255.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":255.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":255.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":255.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":255.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":255.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":255.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":251.0, @@ -929268,11 +933035,11 @@ }, { "sim":250.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":250.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":247.0, @@ -929308,11 +933075,11 @@ }, { "sim":243.0, - "partner":"7dne" + "partner":"2xeh" }, { "sim":243.0, - "partner":"2xeh" + "partner":"7dne" }, { "sim":243.0, @@ -929376,7 +933143,7 @@ }, { "sim":222.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":222.0, @@ -929384,7 +933151,7 @@ }, { "sim":222.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":222.0, @@ -929408,11 +933175,11 @@ }, { "sim":219.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":219.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":219.0, @@ -929436,11 +933203,11 @@ }, { "sim":194.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":194.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":193.0, @@ -929498,6 +933265,10 @@ "sim":173.0, "partner":"8ak1" }, + { + "sim":171.0, + "partner":"9glq" + }, { "sim":171.0, "partner":"5eil" @@ -929528,10 +933299,6 @@ "sim":318.0, "partner":"3zu7" }, - { - "sim":313.0, - "partner":"8g4f" - }, { "sim":313.0, "partner":"8g42" @@ -929548,6 +933315,10 @@ "sim":313.0, "partner":"8g3k" }, + { + "sim":313.0, + "partner":"8g4f" + }, { "sim":300.0, "partner":"8g4e" @@ -929680,30 +933451,18 @@ "sim":255.0, "partner":"6bbn" }, - { - "sim":255.0, - "partner":"7yz0" - }, { "sim":255.0, "partner":"6mzf" }, { "sim":255.0, - "partner":"7yz1" - }, - { - "sim":255.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":255.0, "partner":"5nqt" }, - { - "sim":255.0, - "partner":"6mze" - }, { "sim":255.0, "partner":"7yz2" @@ -929714,11 +933473,11 @@ }, { "sim":255.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":255.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":255.0, @@ -929728,13 +933487,17 @@ "sim":255.0, "partner":"7yz5" }, + { + "sim":255.0, + "partner":"7yz6" + }, { "sim":255.0, "partner":"4lnu" }, { "sim":255.0, - "partner":"7yz6" + "partner":"6zwb" }, { "sim":255.0, @@ -929748,10 +933511,6 @@ "sim":255.0, "partner":"5nm5" }, - { - "sim":255.0, - "partner":"6zwb" - }, { "sim":255.0, "partner":"6zwc" @@ -929766,27 +933525,27 @@ }, { "sim":255.0, - "partner":"6ar6" + "partner":"7yz0" }, { - "sim":254.0, - "partner":"7pjf" + "sim":255.0, + "partner":"7yz1" }, { - "sim":254.0, - "partner":"6s8l" + "sim":255.0, + "partner":"7z01" }, { - "sim":254.0, - "partner":"5eno" + "sim":255.0, + "partner":"6ar6" }, { "sim":254.0, - "partner":"6zob" + "partner":"6s8l" }, { "sim":254.0, - "partner":"6zo5" + "partner":"7pjf" }, { "sim":254.0, @@ -929794,31 +933553,35 @@ }, { "sim":254.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":254.0, "partner":"6zoc" }, + { + "sim":254.0, + "partner":"6zo6" + }, { "sim":254.0, "partner":"5enp" }, { "sim":254.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":254.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":254.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":254.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":254.0, @@ -929830,11 +933593,11 @@ }, { "sim":254.0, - "partner":"6zod" + "partner":"6zo7" }, { "sim":254.0, - "partner":"7b8r" + "partner":"6zoe" }, { "sim":254.0, @@ -929842,19 +933605,15 @@ }, { "sim":254.0, - "partner":"6zo7" - }, - { - "sim":254.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":254.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":254.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":254.0, @@ -929868,10 +933627,6 @@ "sim":254.0, "partner":"4u96" }, - { - "sim":254.0, - "partner":"7b8s" - }, { "sim":254.0, "partner":"6zo8" @@ -929882,15 +933637,11 @@ }, { "sim":254.0, - "partner":"5enr" - }, - { - "sim":254.0, - "partner":"4u8v" + "partner":"6sgu" }, { "sim":254.0, - "partner":"6sgu" + "partner":"5enr" }, { "sim":254.0, @@ -929898,11 +933649,11 @@ }, { "sim":254.0, - "partner":"4lsz" + "partner":"4u8v" }, { "sim":254.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":254.0, @@ -929914,11 +933665,11 @@ }, { "sim":254.0, - "partner":"7b8t" + "partner":"4lsz" }, { "sim":254.0, - "partner":"5ens" + "partner":"5nc5" }, { "sim":254.0, @@ -929926,11 +933677,11 @@ }, { "sim":254.0, - "partner":"5en5" + "partner":"5ens" }, { "sim":254.0, - "partner":"4u8y" + "partner":"5en5" }, { "sim":254.0, @@ -929940,6 +933691,14 @@ "sim":254.0, "partner":"6zoh" }, + { + "sim":254.0, + "partner":"4u8y" + }, + { + "sim":254.0, + "partner":"6sgr" + }, { "sim":254.0, "partner":"4c48" @@ -929954,12 +933713,24 @@ }, { "sim":254.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":254.0, "partner":"4dx5" }, + { + "sim":254.0, + "partner":"5eno" + }, + { + "sim":254.0, + "partner":"6zo5" + }, + { + "sim":254.0, + "partner":"6q4n" + }, { "sim":254.0, "partner":"7alr" @@ -930038,11 +933809,11 @@ }, { "sim":248.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":248.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":248.0, @@ -930114,15 +933885,15 @@ }, { "sim":242.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":242.0, - "partner":"4zfh" + "partner":"8p9e" }, { "sim":242.0, - "partner":"8p9c" + "partner":"4zfh" }, { "sim":242.0, @@ -930132,10 +933903,6 @@ "sim":242.0, "partner":"4k5b" }, - { - "sim":242.0, - "partner":"8tzb" - }, { "sim":242.0, "partner":"8tzc" @@ -930152,6 +933919,10 @@ "sim":242.0, "partner":"8tzh" }, + { + "sim":242.0, + "partner":"8tzb" + }, { "sim":241.0, "partner":"5aq9" @@ -930230,11 +934001,11 @@ }, { "sim":232.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":232.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":232.0, @@ -930258,19 +934029,19 @@ }, { "sim":222.0, - "partner":"4jb8" + "partner":"5mbm" }, { "sim":222.0, - "partner":"5mbm" + "partner":"4jb8" }, { "sim":220.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":220.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":218.0, @@ -930316,10 +934087,6 @@ "sim":195.0, "partner":"7bhf" }, - { - "sim":195.0, - "partner":"7pd8" - }, { "sim":195.0, "partner":"7pdd" @@ -930332,6 +934099,10 @@ "sim":195.0, "partner":"7pdh" }, + { + "sim":195.0, + "partner":"7pd8" + }, { "sim":193.0, "partner":"2v4h" @@ -930486,23 +934257,23 @@ }, { "sim":119.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":119.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":119.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":119.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":119.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":119.0, @@ -930510,11 +934281,11 @@ }, { "sim":119.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":119.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":119.0, @@ -930536,10 +934307,6 @@ "sim":114.0, "partner":"2l6b" }, - { - "sim":110.0, - "partner":"5vhj" - }, { "sim":110.0, "partner":"5vhh" @@ -930570,15 +934337,15 @@ }, { "sim":110.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":110.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":110.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":110.0, @@ -930588,6 +934355,10 @@ "sim":110.0, "partner":"7vxw" }, + { + "sim":110.0, + "partner":"1uoh" + }, { "sim":110.0, "partner":"7vy4" @@ -930598,11 +934369,11 @@ }, { "sim":110.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":110.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":110.0, @@ -930614,15 +934385,15 @@ }, { "sim":109.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":109.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":109.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":109.0, @@ -930786,11 +934557,11 @@ }, { "sim":96.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":96.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":96.0, @@ -930806,11 +934577,11 @@ }, { "sim":95.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":95.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":95.0, @@ -930922,16 +934693,24 @@ }, { "sim":87.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":87.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":87.0, "partner":"7roy" }, + { + "sim":87.0, + "partner":"8wqg" + }, + { + "sim":87.0, + "partner":"8wqe" + }, { "sim":87.0, "partner":"8wqh" @@ -930960,14 +934739,6 @@ "sim":87.0, "partner":"8wqd" }, - { - "sim":87.0, - "partner":"8wqg" - }, - { - "sim":87.0, - "partner":"8wqe" - }, { "sim":87.0, "partner":"8je1" @@ -931008,14 +934779,6 @@ "sim":84.0, "partner":"3eu9" }, - { - "sim":84.0, - "partner":"6m11" - }, - { - "sim":84.0, - "partner":"6m12" - }, { "sim":84.0, "partner":"6m13" @@ -931040,6 +934803,14 @@ "sim":84.0, "partner":"4o1p" }, + { + "sim":84.0, + "partner":"6m11" + }, + { + "sim":84.0, + "partner":"6m12" + }, { "sim":84.0, "partner":"6aun" @@ -931188,10 +934959,6 @@ "sim":79.0, "partner":"6wj5" }, - { - "sim":79.0, - "partner":"6v9x" - }, { "sim":79.0, "partner":"6v9y" @@ -931204,6 +934971,10 @@ "sim":79.0, "partner":"6v9w" }, + { + "sim":79.0, + "partner":"6v9x" + }, { "sim":79.0, "partner":"7or0" @@ -931238,11 +935009,11 @@ }, { "sim":78.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":78.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":77.0, @@ -931258,19 +935029,19 @@ }, { "sim":77.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":77.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":77.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":77.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":77.0, @@ -931296,10 +935067,6 @@ "sim":76.0, "partner":"5wo6" }, - { - "sim":76.0, - "partner":"5iwr" - }, { "sim":76.0, "partner":"5iwt" @@ -931352,6 +935119,10 @@ "sim":76.0, "partner":"5iwp" }, + { + "sim":76.0, + "partner":"5iwr" + }, { "sim":76.0, "partner":"5wo7" @@ -931446,15 +935217,15 @@ }, { "sim":71.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":71.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":71.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":71.0, @@ -931508,10 +935279,6 @@ "sim":70.0, "partner":"3t9k" }, - { - "sim":70.0, - "partner":"6o1p" - }, { "sim":70.0, "partner":"6b5v" @@ -931550,11 +935317,7 @@ }, { "sim":70.0, - "partner":"7t6m" - }, - { - "sim":70.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":70.0, @@ -931590,15 +935353,19 @@ }, { "sim":70.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":70.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":70.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":70.0, + "partner":"7t6k" }, { "sim":70.0, @@ -931606,7 +935373,7 @@ }, { "sim":70.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":70.0, @@ -931614,7 +935381,11 @@ }, { "sim":70.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":70.0, + "partner":"8ffn" }, { "sim":69.0, @@ -931696,10 +935467,6 @@ "sim":64.0, "partner":"8sp8" }, - { - "sim":64.0, - "partner":"7k4a" - }, { "sim":64.0, "partner":"7k4b" @@ -931722,7 +935489,7 @@ }, { "sim":64.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":64.0, @@ -931738,7 +935505,7 @@ }, { "sim":64.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":64.0, @@ -931750,7 +935517,7 @@ }, { "sim":64.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":64.0, @@ -931768,6 +935535,10 @@ "sim":64.0, "partner":"6bo8" }, + { + "sim":64.0, + "partner":"6bo9" + }, { "sim":64.0, "partner":"6sku" @@ -931834,7 +935605,7 @@ }, { "sim":58.0, - "partner":"8gkg" + "partner":"8gka" }, { "sim":58.0, @@ -931842,7 +935613,7 @@ }, { "sim":58.0, - "partner":"8gka" + "partner":"8gkg" }, { "sim":58.0, @@ -931864,10 +935635,6 @@ "sim":58.0, "partner":"8v6o" }, - { - "sim":58.0, - "partner":"6mhw" - }, { "sim":58.0, "partner":"6mhx" @@ -931884,6 +935651,10 @@ "sim":58.0, "partner":"6mhv" }, + { + "sim":58.0, + "partner":"6mhw" + }, { "sim":58.0, "partner":"7xj0" @@ -931922,15 +935693,15 @@ }, { "sim":57.0, - "partner":"6uw9" + "partner":"6uw6" }, { "sim":57.0, - "partner":"6uw6" + "partner":"6uw8" }, { "sim":57.0, - "partner":"6uw8" + "partner":"6uw9" }, { "sim":55.0, @@ -931940,10 +935711,6 @@ "sim":55.0, "partner":"2g2d" }, - { - "sim":55.0, - "partner":"6wh5" - }, { "sim":55.0, "partner":"6wgs" @@ -931956,6 +935723,10 @@ "sim":55.0, "partner":"6wgv" }, + { + "sim":55.0, + "partner":"6wh5" + }, { "sim":54.0, "partner":"4n5q" @@ -931964,10 +935735,6 @@ "sim":53.0, "partner":"6lgp" }, - { - "sim":53.0, - "partner":"6dvz" - }, { "sim":53.0, "partner":"6dvw" @@ -931978,19 +935745,11 @@ }, { "sim":53.0, - "partner":"6pvo" - }, - { - "sim":53.0, - "partner":"7mij" - }, - { - "sim":53.0, - "partner":"6pvp" + "partner":"6dvz" }, { "sim":53.0, - "partner":"7ras" + "partner":"6pvq" }, { "sim":53.0, @@ -931998,7 +935757,7 @@ }, { "sim":53.0, - "partner":"6pvq" + "partner":"7ras" }, { "sim":53.0, @@ -932012,13 +935771,17 @@ "sim":53.0, "partner":"7mim" }, + { + "sim":53.0, + "partner":"6pvl" + }, { "sim":53.0, "partner":"7min" }, { "sim":53.0, - "partner":"6pvl" + "partner":"6pvm" }, { "sim":53.0, @@ -932030,11 +935793,19 @@ }, { "sim":53.0, - "partner":"6pvm" + "partner":"6pvn" }, { "sim":53.0, - "partner":"6pvn" + "partner":"6pvo" + }, + { + "sim":53.0, + "partner":"6pvp" + }, + { + "sim":53.0, + "partner":"7mij" }, { "sim":51.0, @@ -932046,11 +935817,11 @@ }, { "sim":51.0, - "partner":"7ttr" + "partner":"7tts" }, { "sim":51.0, - "partner":"7tts" + "partner":"7ttr" }, { "sim":50.0, @@ -932083,6 +935854,118 @@ "" ] }, + { + "pdb":"8vea", + "picture_path":"https:\/\/cdn.rcsb.org\/images\/structures\/8vea_assembly-1.jpeg", + "chains":[ + { + "chain_id":"A,B,C", + "chain_source":"synthetic construct", + "chain_type":"D", + "chain_seq_unnat":"GFEEALELTIRAKEEGDPRLLERALEILERRLKEAQERGDLHLVLTIALLLAAIAHRLGDPRYLEVAVRVLEEAIREALERGDVQLVYNLVEVLLHVARLLGDPRVFRFMLHILLEAYRIARENGDEQILIEIVHLFTEVIRG", + "chain_seq_nat":"GFEEALELTIRAKEEGDPRLLERALEILERRLKEAQERGDLHLVLTIALLLAAIAHRLGDPRYLEVAVRVLEEAIREALERGDVQLVYNLVEVLLHVARLLGDPRVFRFMLHILLEAYRIARENGDEQILIEIVHLFTEVIRG", + "chain_length":144 + } + ], + "authors":[ + { + "forename":"J.", + "surname":"Sims" + }, + { + "forename":"D.", + "surname":"Baker" + }, + { + "forename":"A.K.", + "surname":"Bera" + } + ], + "classification":"unknown", + "classification_suggested":[ + "computational", + "deep-learning based" + ], + "classification_suggested_reason":[ + "Author is: D. Baker" + ], + "subtitle":"De novo designed helical oligomer sg266", + "tags":[ + "de novo protein", + "mass spectrometry", + "peptide barcoding", + "de novo designed protein" + ], + "keywords":[ + "description", + "found" + ], + "release_date":"2025-01-15", + "publication":"To be published", + "publication_ref":{ + "DOI":"", + "PubMed":"", + "CSD":"", + "ISSN":"", + "ASTM":"" + }, + "publication_country":"", + "abstract":"No description found.", + "crystal_structure":{ + "length_a":"115.335", + "length_b":"115.335", + "length_c":"59.994", + "angle_a":"90.000", + "angle_b":"90.000", + "angle_g":"120.000" + }, + "symmetry":"P 63", + "exptl_method":[ + "X-RAY DIFFRACTION" + ], + "formula_weight":16512.213, + "synthesis_comment":"", + "review":true, + "previous_design":"8ve7", + "next_design":"8vei", + "seq_thr_sim_designed":[ + { + "sim":69.0, + "partner":"7rmx" + }, + { + "sim":56.0, + "partner":"7rmy" + } + ], + "seq_thr_sim_natural":[ + + ], + "struct_thr_sim_designed":[ + + ], + "struct_thr_sim_natural":[ + + ], + "seq_max_sim_designed":{ + "sim":69.0, + "partner":"7rmx" + }, + "seq_max_sim_natural":[ + + ], + "struct_max_sim_designed":{ + "sim":0.7526000142, + "partner":"9dze" + }, + "struct_max_sim_natural":{ + "sim":0.6895999908, + "partner":"6e9r" + }, + "review_comment":[ + "" + ] + }, { "pdb":"8vei", "picture_path":"https:\/\/cdn.rcsb.org\/images\/structures\/8vei_assembly-1.jpeg", @@ -932208,78 +936091,78 @@ ], "subtitle":"De novo designed colic acid binder chd_r1", "tags":[ - "de novo designed protein", + "small molecule binder", "de novo protein", - "colic acid", - "small molecule binder" + "de novo designed protein", + "colic acid" ], "keywords":[ - "diverse", - "designs", - "dock", - "ligand", - "proteins", + "affinity", + "central", "surrounding", - "use", - "approach", + "designing", + "dock", + "design", + "repeating", + "structural", + "reassemble", "geometry", - "taking", - "highest", - "flexible", - "four", - "including", - "identify", - "shape", "number", - "modular", - "small", - "interest", - "surfaces", - "induced", - "shapes", + "repeat", + "highest", "binders", - "complementary", - "reassemble", + "interest", + "diverse", "experimentally", - "thyroxine", + "screen", + "ligand", + "methotrexate", + "nanopore", + "structure", "pseudocycles", - "sensors", - "central", - "obtain", + "addition", + "shape", "polar", + "flexible", + "widely", + "surfaces", "chemically", - "design", + "pockets", + "approach", + "proteins", + "binding", + "dimerization", + "molecules", + "interaction", + "thyroxine", + "varying", + "use", + "identify", + "units", "sensing", + "shapes", + "downstream", + "high", + "advantage", + "modular", "splitting", - "units", "domains", - "downstream", - "methotrexate", "upon", - "advantage", - "nanopore", - "widely", - "pockets", - "designing", - "repeating", + "small", + "systems", + "sensors", + "taking", + "induced", + "poised", "describe", - "high", - "structure", - "construct", - "repeat", - "varying", "depend", - "screen", - "addition", + "four", + "designs", + "construct", + "complementary", + "including", "deep", - "affinity", - "molecules", - "systems", - "binding", - "structural", - "poised", - "dimerization", - "interaction" + "obtain" ], "release_date":"2024-07-17", "publication":"\"Binding and sensing diverse small molecules using shape-complementary pseudocycles\", Science, 385, 276-282", @@ -932307,7 +936190,7 @@ "formula_weight":14795.93, "synthesis_comment":"", "review":true, - "previous_design":"8ve7", + "previous_design":"8vea", "next_design":"8vej", "seq_thr_sim_designed":[ @@ -932465,78 +936348,78 @@ ], "subtitle":"De novo designed cholic acid binder: chd_buttress", "tags":[ - "de novo designed protein", + "small molecule binder", "de novo protein", "cholic acid", - "small molecule binder" + "de novo designed protein" ], "keywords":[ - "diverse", - "designs", - "dock", - "ligand", - "proteins", + "affinity", + "central", "surrounding", - "use", - "approach", + "designing", + "dock", + "design", + "repeating", + "structural", + "reassemble", "geometry", - "taking", - "highest", - "flexible", - "four", - "including", - "identify", - "shape", "number", - "modular", - "small", - "interest", - "surfaces", - "induced", - "shapes", + "repeat", + "highest", "binders", - "complementary", - "reassemble", + "interest", + "diverse", "experimentally", - "thyroxine", + "screen", + "ligand", + "methotrexate", + "nanopore", + "structure", "pseudocycles", - "sensors", - "central", - "obtain", + "addition", + "shape", "polar", + "flexible", + "widely", + "surfaces", "chemically", - "design", + "pockets", + "approach", + "proteins", + "binding", + "dimerization", + "molecules", + "interaction", + "thyroxine", + "varying", + "use", + "identify", + "units", "sensing", + "shapes", + "downstream", + "high", + "advantage", + "modular", "splitting", - "units", "domains", - "downstream", - "methotrexate", "upon", - "advantage", - "nanopore", - "widely", - "pockets", - "designing", - "repeating", + "small", + "systems", + "sensors", + "taking", + "induced", + "poised", "describe", - "high", - "structure", - "construct", - "repeat", - "varying", "depend", - "screen", - "addition", + "four", + "designs", + "construct", + "complementary", + "including", "deep", - "affinity", - "molecules", - "systems", - "binding", - "structural", - "poised", - "dimerization", - "interaction" + "obtain" ], "release_date":"2024-07-17", "publication":"\"Binding and sensing diverse small molecules using shape-complementary pseudocycles\", Science, 385, 276-282", @@ -932565,7 +936448,7 @@ "synthesis_comment":"", "review":true, "previous_design":"8vei", - "next_design":"8vfq", + "next_design":"8vez", "seq_thr_sim_designed":[ ], @@ -932597,6 +936480,116 @@ "" ] }, + { + "pdb":"8vez", + "picture_path":"https:\/\/cdn.rcsb.org\/images\/structures\/8vez_assembly-1.jpeg", + "chains":[ + { + "chain_id":"A", + "chain_source":"synthetic construct", + "chain_type":"D", + "chain_seq_unnat":"SGGSSARIAKAKKLIYKLEKLWNARDNDGILKLFKDDAVFNLNGVPYKGKEAIKKVLESAPKAKYKITKIDIKIVGNEIIVNVDVLATGPSGFTLKVKSTITFDEDMKITSYEVNLEGS", + "chain_seq_nat":"SGGSSARIAKAKKLIYKLEKLWNARDNDGILKLFKDDAVFNLNGVPYKGKEAIKKVLESAPKAKYKITKIDIKIVGNEIIVNVDVLATGPSGFTLKVKSTITFDEDMKITSYEVNLEGS", + "chain_length":120 + } + ], + "authors":[ + { + "forename":"G.R.", + "surname":"Lee" + }, + { + "forename":"A.K.", + "surname":"Bera" + }, + { + "forename":"D.", + "surname":"Baker" + } + ], + "classification":"unknown", + "classification_suggested":[ + "computational", + "deep-learning based" + ], + "classification_suggested_reason":[ + "Author is: D. Baker" + ], + "subtitle":"De novo design apixaban-binding protein: apx1049", + "tags":[ + "small-molecule-binding", + "de novo design", + "de novo protein", + "deep learning", + "protein design", + "apixaban" + ], + "keywords":[ + "description", + "found" + ], + "release_date":"2025-01-15", + "publication":"To be published", + "publication_ref":{ + "DOI":"", + "PubMed":"", + "CSD":"", + "ISSN":"", + "ASTM":"" + }, + "publication_country":"", + "abstract":"No description found.", + "crystal_structure":{ + "length_a":"54.971", + "length_b":"64.176", + "length_c":"60.108", + "angle_a":"90.000", + "angle_b":"90.000", + "angle_g":"90.000" + }, + "symmetry":"C 2 2 21", + "exptl_method":[ + "X-RAY DIFFRACTION" + ], + "formula_weight":13098.239, + "synthesis_comment":"", + "review":true, + "previous_design":"8vej", + "next_design":"8vfq", + "seq_thr_sim_designed":[ + { + "sim":229.0, + "partner":"8vfq" + } + ], + "seq_thr_sim_natural":[ + + ], + "struct_thr_sim_designed":[ + + ], + "struct_thr_sim_natural":[ + + ], + "seq_max_sim_designed":{ + "sim":229.0, + "partner":"8vfq" + }, + "seq_max_sim_natural":[ + + ], + "struct_max_sim_designed":{ + "sim":0.9437000155, + "partner":"8vfq" + }, + "struct_max_sim_natural":{ + "sim":0.7736999989, + "partner":"1ask" + }, + "review_comment":[ + "" + ] + }, { "pdb":"8vfq", "picture_path":"https:\/\/cdn.rcsb.org\/images\/structures\/8vfq_assembly-1.jpeg", @@ -932635,10 +936628,10 @@ "subtitle":"De novo design apixaban-binding protein: apx1049", "tags":[ "small-molecule-binding", - "deep learning", + "de novo design", "de novo protein", - "protein design", - "de novo design" + "deep learning", + "protein design" ], "keywords":[ "description", @@ -932670,29 +936663,36 @@ "formula_weight":12954.11, "synthesis_comment":"", "review":true, - "previous_design":"8vej", + "previous_design":"8vez", "next_design":"8vl3", "seq_thr_sim_designed":[ - + { + "sim":229.0, + "partner":"8vez" + } ], "seq_thr_sim_natural":[ ], "struct_thr_sim_designed":[ - + { + "sim":0.9603000283, + "partner":"8vez" + } ], "struct_thr_sim_natural":[ ], - "seq_max_sim_designed":[ - - ], + "seq_max_sim_designed":{ + "sim":229.0, + "partner":"8vez" + }, "seq_max_sim_natural":[ ], "struct_max_sim_designed":{ - "sim":0.7048000097, - "partner":"5ieo" + "sim":0.9603000283, + "partner":"8vez" }, "struct_max_sim_natural":{ "sim":0.7846000195, @@ -932717,20 +936717,89 @@ ], "authors":[ { - "forename":"A.C.", - "surname":"McShan" + "forename":"S.L.", + "surname":"Lisanza" + }, + { + "forename":"J.M.", + "surname":"Gershon" + }, + { + "forename":"S.W.K.", + "surname":"Tipps" + }, + { + "forename":"J.N.", + "surname":"Sims" + }, + { + "forename":"L.", + "surname":"Arnoldt" + }, + { + "forename":"S.J.", + "surname":"Hendel" }, { "forename":"M.K.", "surname":"Simma" + }, + { + "forename":"G.", + "surname":"Liu" + }, + { + "forename":"M.", + "surname":"Yase" + }, + { + "forename":"H.", + "surname":"Wu" + }, + { + "forename":"C.D.", + "surname":"Tharp" + }, + { + "forename":"X.", + "surname":"Li" + }, + { + "forename":"A.", + "surname":"Kang" + }, + { + "forename":"E.", + "surname":"Brackenbrough" + }, + { + "forename":"A.K.", + "surname":"Bera" + }, + { + "forename":"S.", + "surname":"Gerben" + }, + { + "forename":"B.J.", + "surname":"Wittmann" + }, + { + "forename":"A.C.", + "surname":"McShan" + }, + { + "forename":"D.", + "surname":"Baker" } ], "classification":"unknown", "classification_suggested":[ - + "computational", + "deep-learning based" ], "classification_suggested_reason":[ - + "Author is: D. Baker" ], "subtitle":"Solution nmr structure of de novo designed protein f3 parent", "tags":[ @@ -932740,96 +936809,96 @@ "machine learning" ], "keywords":[ - "beginning", - "constraints", - "intact", - "providing", - "acid", - "designed", - "probabilistic", - "trajectories", + "repeats", "limited", - "based", - "sequences", + "triples", + "structural", "overcome", - "generates", - "split", - "structure", - "denoising", - "compositions", - "limitation", - "backbones", "thermostable", - "general", - "models", - "proteins", - "de", - "multistate", - "child", - "used", - "ability", - "structures", - "versus", - "pairs", - "function", - "averaging", + "experimental", + "probabilistic", "simultaneously", - "properties", - "generation", + "acid", + "model", + "protein", + "rosettafold", + "child", + "limitation", + "guided", + "trajectories", + "novo", + "general", + "pg", + "domains", + "split", + "bioactive", "parent", - "data", - "functional", - "guide", - "amino", - "cage", + "two", + "backbones", + "supersecondary", + "integrated", "optimization", + "approach", + "proteins", + "compositions", + "constraints", + "cage", "noised", - "design", - "model", "iterative", - "diffusion", - "sequence", - "repeats", + "computational", + "pairs", + "design", + "used", + "functional", + "different", "representation", + "properties", + "amino", + "generates", + "varying", + "ability", + "multistate", + "sequence", + "peptides", + "developed", + "versus", "melittin", - "structural", - "guided", - "bioactive", - "rosettafold", - "logits", - "approach", - "novo", "desired", - "experimental", - "proteingenerator", - "peptides", - "pg", - "different", - "supersecondary", - "two", "folds", - "domains", - "integrated", - "triples", - "protein", + "designed", + "models", + "generation", + "sequences", + "beginning", + "logits", "space", + "providing", + "structures", + "de", + "proteingenerator", + "based", + "structure", + "intact", + "function", + "internal", "attributes", - "varying", "distinct", - "computational", - "internal", - "developed" + "guide", + "denoising", + "data", + "diffusion", + "averaging" ], "release_date":"2024-08-07", - "publication":"To be published", + "publication":"\"Multistate and functional protein design using RoseTTAFold sequence space diffusion\", Nat.Biotechnol.", "publication_ref":{ - "DOI":"", - "PubMed":"", - "CSD":"", - "ISSN":"", - "ASTM":"" + "DOI":"10.1038\/s41587-024-02395-w", + "PubMed":"39322764", + "CSD":"2119", + "ISSN":"1087-0156", + "ASTM":"NABIF9" }, - "publication_country":"", + "publication_country":"US", "abstract":"Protein denoising diffusion probabilistic models are used for the de novo generation of protein backbones but are limited in their ability to guide generation of proteins with sequence-specific attributes and functional properties. To overcome this limitation, we developed ProteinGenerator (PG), a sequence space diffusion model based on RoseTTAFold that simultaneously generates protein sequences and structures. Beginning from a noised sequence representation, PG generates sequence and structure pairs by iterative denoising, guided by desired sequence and structural protein attributes. We designed thermostable proteins with varying amino acid compositions and internal sequence repeats and cage bioactive peptides, such as melittin. By averaging sequence logits between diffusion trajectories with distinct structural constraints, we designed multistate parent-child protein triples in which the same sequence folds to different supersecondary structures when intact in the parent versus split into two child domains. PG design trajectories can be guided by experimental sequence-activity data, providing a general approach for integrated computational and experimental optimization of protein function.", "crystal_structure":{ "length_a":"", @@ -932897,20 +936966,89 @@ ], "authors":[ { - "forename":"A.C.", - "surname":"McShan" + "forename":"S.L.", + "surname":"Lisanza" + }, + { + "forename":"J.M.", + "surname":"Gershon" + }, + { + "forename":"S.W.K.", + "surname":"Tipps" + }, + { + "forename":"J.N.", + "surname":"Sims" + }, + { + "forename":"L.", + "surname":"Arnoldt" + }, + { + "forename":"S.J.", + "surname":"Hendel" }, { "forename":"M.K.", "surname":"Simma" + }, + { + "forename":"G.", + "surname":"Liu" + }, + { + "forename":"M.", + "surname":"Yase" + }, + { + "forename":"H.", + "surname":"Wu" + }, + { + "forename":"C.D.", + "surname":"Tharp" + }, + { + "forename":"X.", + "surname":"Li" + }, + { + "forename":"A.", + "surname":"Kang" + }, + { + "forename":"E.", + "surname":"Brackenbrough" + }, + { + "forename":"A.K.", + "surname":"Bera" + }, + { + "forename":"S.", + "surname":"Gerben" + }, + { + "forename":"B.J.", + "surname":"Wittmann" + }, + { + "forename":"A.C.", + "surname":"McShan" + }, + { + "forename":"D.", + "surname":"Baker" } ], "classification":"unknown", "classification_suggested":[ - + "computational", + "deep-learning based" ], "classification_suggested_reason":[ - + "Author is: D. Baker" ], "subtitle":"Solution nmr structure of de novo design protein 312 parent", "tags":[ @@ -932920,96 +937058,96 @@ "machine learning" ], "keywords":[ - "beginning", - "constraints", - "intact", - "providing", - "acid", - "designed", - "probabilistic", - "trajectories", + "repeats", "limited", - "based", - "sequences", + "triples", + "structural", "overcome", - "generates", - "split", - "structure", - "denoising", - "compositions", - "limitation", - "backbones", "thermostable", - "general", - "models", - "proteins", - "de", - "multistate", - "child", - "used", - "ability", - "structures", - "versus", - "pairs", - "function", - "averaging", + "experimental", + "probabilistic", "simultaneously", - "properties", - "generation", + "acid", + "model", + "protein", + "rosettafold", + "child", + "limitation", + "guided", + "trajectories", + "novo", + "general", + "pg", + "domains", + "split", + "bioactive", "parent", - "data", - "functional", - "guide", - "amino", - "cage", + "two", + "backbones", + "supersecondary", + "integrated", "optimization", + "approach", + "proteins", + "compositions", + "constraints", + "cage", "noised", - "design", - "model", "iterative", - "diffusion", - "sequence", - "repeats", + "computational", + "pairs", + "design", + "used", + "functional", + "different", "representation", + "properties", + "amino", + "generates", + "varying", + "ability", + "multistate", + "sequence", + "peptides", + "developed", + "versus", "melittin", - "structural", - "guided", - "bioactive", - "rosettafold", - "logits", - "approach", - "novo", "desired", - "experimental", - "proteingenerator", - "peptides", - "pg", - "different", - "supersecondary", - "two", "folds", - "domains", - "integrated", - "triples", - "protein", + "designed", + "models", + "generation", + "sequences", + "beginning", + "logits", "space", + "providing", + "structures", + "de", + "proteingenerator", + "based", + "structure", + "intact", + "function", + "internal", "attributes", - "varying", "distinct", - "computational", - "internal", - "developed" + "guide", + "denoising", + "data", + "diffusion", + "averaging" ], "release_date":"2024-08-07", - "publication":"To be published", + "publication":"\"Multistate and functional protein design using RoseTTAFold sequence space diffusion\", Nat.Biotechnol.", "publication_ref":{ - "DOI":"", - "PubMed":"", - "CSD":"", - "ISSN":"", - "ASTM":"" + "DOI":"10.1038\/s41587-024-02395-w", + "PubMed":"39322764", + "CSD":"2119", + "ISSN":"1087-0156", + "ASTM":"NABIF9" }, - "publication_country":"", + "publication_country":"US", "abstract":"Protein denoising diffusion probabilistic models are used for the de novo generation of protein backbones but are limited in their ability to guide generation of proteins with sequence-specific attributes and functional properties. To overcome this limitation, we developed ProteinGenerator (PG), a sequence space diffusion model based on RoseTTAFold that simultaneously generates protein sequences and structures. Beginning from a noised sequence representation, PG generates sequence and structure pairs by iterative denoising, guided by desired sequence and structural protein attributes. We designed thermostable proteins with varying amino acid compositions and internal sequence repeats and cage bioactive peptides, such as melittin. By averaging sequence logits between diffusion trajectories with distinct structural constraints, we designed multistate parent-child protein triples in which the same sequence folds to different supersecondary structures when intact in the parent versus split into two child domains. PG design trajectories can be guided by experimental sequence-activity data, providing a general approach for integrated computational and experimental optimization of protein function.", "crystal_structure":{ "length_a":"", @@ -933110,112 +937248,112 @@ "synthetic construct" ], "keywords":[ + "polyaromatic", + "tectons", "tune", - "conjugated", - "architecture", + "development", + "additional", + "number", + "polarity", + "single", + "rationally", "intermolecular", - "influences", + "pore", + "elongation", "acid", - "peptide", - "including", - "shapes", - "tuning", - "generally", - "find", - "lastly", - "interactions", - "designing", - "structure", - "diversity", - "networks", - "building", - "novel", - "porous", - "like", - "aim", - "strategies", + "framework", + "protein", "adjusting", - "suggesting", - "integrate", - "unique", - "produce", - "modulate", - "straightforward", - "pore", - "number", - "strongly", - "advanced", - "simple", - "simpler", - "materials", - "structures", - "complexity", - "essential", - "representing", - "assembly", - "size", "significantly", - "additional", - "indirectly", - "predictably", - "properties", "rapid", - "framework", - "data", - "accelerate", + "predicting", + "essential", + "networks", + "straightforward", + "hindered", + "predictors", "expected", - "amino", - "identity", - "frameworks", + "weak", + "predictably", + "using", + "correlating", + "complex", + "indirectly", + "conjugated", + "influences", + "residues", "factors", - "assemblies", - "geometry", + "frameworks", + "occur", + "case", + "integrate", + "strongly", + "representing", + "blocks", + "generally", "remarkable", - "report", - "dimension", - "detailed", - "shape", - "elongation", + "size", + "architecture", "growing", - "engineer", - "polarity", - "blocks", - "crystallographic", - "predicting", - "rationally", - "using", - "weak", - "occur", - "insertion", - "sequence", + "shapes", + "modulate", + "suggesting", + "like", + "including", + "peptide", "difficulty", - "could", + "designing", + "identity", + "simpler", + "simple", + "produce", + "assembly", + "properties", + "sizes", + "porous", + "diversity", + "also", + "driven", + "groups", + "insertion", + "complexity", + "amino", "notably", - "hindered", - "polyaromatic", + "building", + "sequence", "angle", - "capabilities", - "despite", "jumps", - "groups", - "also", - "predictors", - "single", - "driven", - "sizes", "peptides", - "appears", - "residues", + "capabilities", "mesoporous", - "tectons", - "guidelines", + "unique", + "assemblies", + "materials", "mechanism", - "protein", - "complex", - "development", - "case", + "engineer", + "crystallographic", + "accelerate", + "aim", + "could", + "strategies", + "geometry", + "structures", + "detailed", + "structure", + "report", + "shape", + "interactions", + "guidelines", + "tuning", + "find", + "lastly", + "appears", + "despite", + "data", "create", - "correlating" + "dimension", + "novel", + "advanced" ], "release_date":"2024-08-07", "publication":"\"Diverse Proteomimetic Frameworks via Rational Design of pi-Stacking Peptide Tectons\", J.Am.Chem.Soc., 146, 22236-22246", @@ -933333,112 +937471,112 @@ "synthetic construct" ], "keywords":[ + "polyaromatic", + "tectons", "tune", - "conjugated", - "architecture", + "development", + "additional", + "number", + "polarity", + "single", + "rationally", "intermolecular", - "influences", + "pore", + "elongation", "acid", - "peptide", - "including", - "shapes", - "tuning", - "generally", - "find", - "lastly", - "interactions", - "designing", - "structure", - "diversity", - "networks", - "building", - "novel", - "porous", - "like", - "aim", - "strategies", + "framework", + "protein", "adjusting", - "suggesting", - "integrate", - "unique", - "produce", - "modulate", - "straightforward", - "pore", - "number", - "strongly", - "advanced", - "simple", - "simpler", - "materials", - "structures", - "complexity", - "essential", - "representing", - "assembly", - "size", "significantly", - "additional", - "indirectly", - "predictably", - "properties", "rapid", - "framework", - "data", - "accelerate", + "predicting", + "essential", + "networks", + "straightforward", + "hindered", + "predictors", "expected", - "amino", - "identity", - "frameworks", + "weak", + "predictably", + "using", + "correlating", + "complex", + "indirectly", + "conjugated", + "influences", + "residues", "factors", - "assemblies", - "geometry", + "frameworks", + "occur", + "case", + "integrate", + "strongly", + "representing", + "blocks", + "generally", "remarkable", - "report", - "dimension", - "detailed", - "shape", - "elongation", + "size", + "architecture", "growing", - "engineer", - "polarity", - "blocks", - "crystallographic", - "predicting", - "rationally", - "using", - "weak", - "occur", - "insertion", - "sequence", + "shapes", + "modulate", + "suggesting", + "like", + "including", + "peptide", "difficulty", - "could", + "designing", + "identity", + "simpler", + "simple", + "produce", + "assembly", + "properties", + "sizes", + "porous", + "diversity", + "also", + "driven", + "groups", + "insertion", + "complexity", + "amino", "notably", - "hindered", - "polyaromatic", + "building", + "sequence", "angle", - "capabilities", - "despite", "jumps", - "groups", - "also", - "predictors", - "single", - "driven", - "sizes", "peptides", - "appears", - "residues", + "capabilities", "mesoporous", - "tectons", - "guidelines", + "unique", + "assemblies", + "materials", "mechanism", - "protein", - "complex", - "development", - "case", + "engineer", + "crystallographic", + "accelerate", + "aim", + "could", + "strategies", + "geometry", + "structures", + "detailed", + "structure", + "report", + "shape", + "interactions", + "guidelines", + "tuning", + "find", + "lastly", + "appears", + "despite", + "data", "create", - "correlating" + "dimension", + "novel", + "advanced" ], "release_date":"2024-08-07", "publication":"\"Diverse Proteomimetic Frameworks via Rational Design of pi-Stacking Peptide Tectons\", J.Am.Chem.Soc., 146, 22236-22246", @@ -933548,112 +937686,112 @@ "synthetic construct" ], "keywords":[ + "polyaromatic", + "tectons", "tune", - "conjugated", - "architecture", + "development", + "additional", + "number", + "polarity", + "single", + "rationally", "intermolecular", - "influences", + "pore", + "elongation", "acid", - "peptide", - "including", - "shapes", - "tuning", - "generally", - "find", - "lastly", - "interactions", - "designing", - "structure", - "diversity", - "networks", - "building", - "novel", - "porous", - "like", - "aim", - "strategies", + "framework", + "protein", "adjusting", - "suggesting", - "integrate", - "unique", - "produce", - "modulate", - "straightforward", - "pore", - "number", - "strongly", - "advanced", - "simple", - "simpler", - "materials", - "structures", - "complexity", - "essential", - "representing", - "assembly", - "size", "significantly", - "additional", - "indirectly", - "predictably", - "properties", "rapid", - "framework", - "data", - "accelerate", + "predicting", + "essential", + "networks", + "straightforward", + "hindered", + "predictors", "expected", - "amino", - "identity", - "frameworks", + "weak", + "predictably", + "using", + "correlating", + "complex", + "indirectly", + "conjugated", + "influences", + "residues", "factors", - "assemblies", - "geometry", + "frameworks", + "occur", + "case", + "integrate", + "strongly", + "representing", + "blocks", + "generally", "remarkable", - "report", - "dimension", - "detailed", - "shape", - "elongation", + "size", + "architecture", "growing", - "engineer", - "polarity", - "blocks", - "crystallographic", - "predicting", - "rationally", - "using", - "weak", - "occur", - "insertion", - "sequence", + "shapes", + "modulate", + "suggesting", + "like", + "including", + "peptide", "difficulty", - "could", + "designing", + "identity", + "simpler", + "simple", + "produce", + "assembly", + "properties", + "sizes", + "porous", + "diversity", + "also", + "driven", + "groups", + "insertion", + "complexity", + "amino", "notably", - "hindered", - "polyaromatic", + "building", + "sequence", "angle", - "capabilities", - "despite", "jumps", - "groups", - "also", - "predictors", - "single", - "driven", - "sizes", "peptides", - "appears", - "residues", + "capabilities", "mesoporous", - "tectons", - "guidelines", + "unique", + "assemblies", + "materials", "mechanism", - "protein", - "complex", - "development", - "case", + "engineer", + "crystallographic", + "accelerate", + "aim", + "could", + "strategies", + "geometry", + "structures", + "detailed", + "structure", + "report", + "shape", + "interactions", + "guidelines", + "tuning", + "find", + "lastly", + "appears", + "despite", + "data", "create", - "correlating" + "dimension", + "novel", + "advanced" ], "release_date":"2024-08-07", "publication":"\"Diverse Proteomimetic Frameworks via Rational Design of pi-Stacking Peptide Tectons\", J.Am.Chem.Soc., 146, 22236-22246", @@ -933771,112 +937909,112 @@ "synthetic construct" ], "keywords":[ + "polyaromatic", + "tectons", "tune", - "conjugated", - "architecture", + "development", + "additional", + "number", + "polarity", + "single", + "rationally", "intermolecular", - "influences", + "pore", + "elongation", "acid", - "peptide", - "including", - "shapes", - "tuning", - "generally", - "find", - "lastly", - "interactions", - "designing", - "structure", - "diversity", - "networks", - "building", - "novel", - "porous", - "like", - "aim", - "strategies", + "framework", + "protein", "adjusting", - "suggesting", - "integrate", - "unique", - "produce", - "modulate", - "straightforward", - "pore", - "number", - "strongly", - "advanced", - "simple", - "simpler", - "materials", - "structures", - "complexity", - "essential", - "representing", - "assembly", - "size", "significantly", - "additional", - "indirectly", - "predictably", - "properties", "rapid", - "framework", - "data", - "accelerate", + "predicting", + "essential", + "networks", + "straightforward", + "hindered", + "predictors", "expected", - "amino", - "identity", - "frameworks", + "weak", + "predictably", + "using", + "correlating", + "complex", + "indirectly", + "conjugated", + "influences", + "residues", "factors", - "assemblies", - "geometry", + "frameworks", + "occur", + "case", + "integrate", + "strongly", + "representing", + "blocks", + "generally", "remarkable", - 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"correlating" + "dimension", + "novel", + "advanced" ], "release_date":"2024-08-07", "publication":"\"Diverse Proteomimetic Frameworks via Rational Design of pi-Stacking Peptide Tectons\", J.Am.Chem.Soc., 146, 22236-22246", @@ -933994,112 +938132,112 @@ "synthetic construct" ], "keywords":[ + "polyaromatic", + "tectons", "tune", - "conjugated", - "architecture", + "development", + "additional", + "number", + "polarity", + "single", + "rationally", "intermolecular", - "influences", + "pore", + "elongation", "acid", - "peptide", - "including", - "shapes", - "tuning", - "generally", - "find", - "lastly", - "interactions", - "designing", - "structure", - "diversity", - "networks", - "building", - "novel", - "porous", - "like", - "aim", - "strategies", + "framework", + "protein", "adjusting", - "suggesting", - "integrate", - "unique", - "produce", - "modulate", - "straightforward", - "pore", - "number", - "strongly", - "advanced", - "simple", - "simpler", - "materials", - "structures", - "complexity", - 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"conjugated", - "architecture", + "development", + "additional", + "number", + "polarity", + "single", + "rationally", "intermolecular", - "influences", + "pore", + "elongation", "acid", - "peptide", - "including", - "shapes", - "tuning", - "generally", - "find", - "lastly", - "interactions", - "designing", - "structure", - "diversity", - "networks", - "building", - "novel", - "porous", - "like", - "aim", - "strategies", + "framework", + "protein", "adjusting", - "suggesting", - "integrate", - "unique", - "produce", - "modulate", - "straightforward", - "pore", - "number", - "strongly", - "advanced", - "simple", - "simpler", - "materials", - "structures", - "complexity", - "essential", - "representing", - "assembly", - "size", "significantly", - "additional", - "indirectly", - "predictably", - "properties", "rapid", - "framework", - "data", - "accelerate", + "predicting", + "essential", + "networks", + "straightforward", + "hindered", + "predictors", "expected", - "amino", - "identity", - 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"influences", + "pore", + "elongation", "acid", - "peptide", - "including", - "shapes", - "tuning", - "generally", - "find", - "lastly", - "interactions", - "designing", - "structure", - "diversity", - "networks", - "building", - "novel", - "porous", - "like", - "aim", - "strategies", + "framework", + "protein", "adjusting", - "suggesting", - "integrate", - "unique", - "produce", - "modulate", - "straightforward", - "pore", - "number", - "strongly", - "advanced", - "simple", - "simpler", - "materials", - "structures", - "complexity", - "essential", - "representing", - "assembly", - "size", "significantly", - "additional", - "indirectly", - "predictably", - "properties", "rapid", - "framework", - "data", - "accelerate", + "predicting", + "essential", + "networks", + "straightforward", + "hindered", + "predictors", "expected", - "amino", - "identity", - "frameworks", + "weak", + "predictably", + "using", + "correlating", + "complex", + "indirectly", + "conjugated", + "influences", + "residues", "factors", - 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"lastly", - "interactions", - "designing", - "structure", - "diversity", - "networks", - "building", - "novel", - "porous", - "like", - "aim", - "strategies", + "framework", + "protein", "adjusting", - "suggesting", - "integrate", - "unique", - "produce", - "modulate", - "straightforward", - "pore", - "number", - "strongly", - "advanced", - "simple", - "simpler", - "materials", - "structures", - "complexity", - "essential", - "representing", - "assembly", - "size", "significantly", - "additional", - "indirectly", - "predictably", - "properties", "rapid", - "framework", - "data", - "accelerate", + "predicting", + "essential", + "networks", + "straightforward", + "hindered", + "predictors", "expected", - "amino", - "identity", - "frameworks", + "weak", + "predictably", + "using", + "correlating", + "complex", + "indirectly", + "conjugated", + "influences", + "residues", "factors", - "assemblies", - "geometry", + "frameworks", + "occur", + "case", + "integrate", + "strongly", + "representing", + "blocks", + "generally", "remarkable", - 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"correlating" + "dimension", + "novel", + "advanced" ], "release_date":"2024-08-07", "publication":"\"Diverse Proteomimetic Frameworks via Rational Design of pi-Stacking Peptide Tectons\", J.Am.Chem.Soc., 146, 22236-22246", @@ -934862,112 +939000,112 @@ "synthetic construct" ], "keywords":[ + "polyaromatic", + "tectons", "tune", - "conjugated", - "architecture", - "intermolecular", - "influences", - "acid", - "peptide", - "including", - "shapes", - "tuning", - "generally", - "find", - "lastly", - "interactions", - "designing", - "structure", - "diversity", - "networks", - "building", - "novel", - "porous", - "like", - "aim", - "strategies", - "adjusting", - "suggesting", - "integrate", - "unique", - "produce", - "modulate", - "straightforward", - "pore", + "development", + "additional", "number", - "strongly", - "advanced", - "simple", - "simpler", - "materials", - "structures", - "complexity", - "essential", - "representing", - "assembly", - "size", + "polarity", + "single", + "rationally", + "intermolecular", + "pore", + "elongation", + "acid", + "framework", + "protein", + "adjusting", "significantly", - 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"hindered", - "polyaromatic", + "building", + "sequence", "angle", - "capabilities", - "despite", "jumps", - "groups", - "also", - "predictors", - "single", - "driven", - "sizes", "peptides", - "appears", - "residues", + "capabilities", "mesoporous", - "tectons", - "guidelines", + "unique", + "assemblies", + "materials", "mechanism", - "protein", - "complex", - "development", - "case", + "engineer", + "crystallographic", + "accelerate", + "aim", + "could", + "strategies", + "geometry", + "structures", + "detailed", + "structure", + "report", + "shape", + "interactions", + "guidelines", + "tuning", + "find", + "lastly", + "appears", + "despite", + "data", "create", - "correlating" + "dimension", + "novel", + "advanced" ], "release_date":"2024-08-07", "publication":"\"Diverse Proteomimetic Frameworks via Rational Design of pi-Stacking Peptide Tectons\", J.Am.Chem.Soc., 146, 22236-22246", @@ -935073,112 +939211,112 @@ "synthetic construct" ], "keywords":[ + "polyaromatic", + "tectons", "tune", - "conjugated", - "architecture", + "development", + "additional", + "number", + "polarity", + "single", + "rationally", "intermolecular", - "influences", + "pore", + "elongation", "acid", - "peptide", - "including", - "shapes", - "tuning", - "generally", - "find", - "lastly", - "interactions", - "designing", - "structure", - "diversity", - "networks", - "building", - "novel", - "porous", - "like", - "aim", - "strategies", + "framework", + "protein", "adjusting", - "suggesting", - "integrate", - "unique", - "produce", - "modulate", - "straightforward", - "pore", - "number", - "strongly", - "advanced", - "simple", - "simpler", - "materials", - "structures", - "complexity", - "essential", - "representing", - "assembly", - "size", "significantly", - "additional", - "indirectly", - "predictably", - "properties", "rapid", - "framework", - "data", - "accelerate", + "predicting", + "essential", + "networks", + "straightforward", + "hindered", + "predictors", "expected", - "amino", - "identity", - "frameworks", + "weak", + "predictably", + "using", + "correlating", + "complex", + "indirectly", + "conjugated", + "influences", + "residues", "factors", - "assemblies", - "geometry", + "frameworks", + "occur", + "case", + "integrate", + "strongly", + "representing", + "blocks", + "generally", "remarkable", - "report", - "dimension", - "detailed", - "shape", - "elongation", + "size", + "architecture", "growing", - "engineer", - "polarity", - "blocks", - "crystallographic", - "predicting", - "rationally", - "using", - "weak", - "occur", - "insertion", - "sequence", + "shapes", + "modulate", + "suggesting", + "like", + "including", + "peptide", "difficulty", - "could", + "designing", + "identity", + "simpler", + "simple", + "produce", + "assembly", + "properties", + "sizes", + "porous", + "diversity", + "also", + "driven", + "groups", + "insertion", + "complexity", + "amino", "notably", - "hindered", - "polyaromatic", + "building", + "sequence", "angle", - "capabilities", - "despite", "jumps", - "groups", - "also", - "predictors", - "single", - "driven", - "sizes", "peptides", - "appears", - "residues", + "capabilities", "mesoporous", - "tectons", - "guidelines", + "unique", + "assemblies", + "materials", "mechanism", - "protein", - "complex", - "development", - "case", + "engineer", + "crystallographic", + "accelerate", + "aim", + "could", + "strategies", + "geometry", + "structures", + "detailed", + "structure", + "report", + "shape", + "interactions", + "guidelines", + "tuning", + "find", + "lastly", + "appears", + "despite", + "data", "create", - "correlating" + "dimension", + "novel", + "advanced" ], "release_date":"2024-08-07", "publication":"\"Diverse Proteomimetic Frameworks via Rational Design of pi-Stacking Peptide Tectons\", J.Am.Chem.Soc., 146, 22236-22246", @@ -935284,112 +939422,112 @@ "synthetic construct" ], "keywords":[ + "polyaromatic", + "tectons", "tune", - "conjugated", - "architecture", + "development", + "additional", + "number", + "polarity", + "single", + "rationally", "intermolecular", - "influences", + "pore", + "elongation", "acid", - "peptide", - "including", - "shapes", - "tuning", - "generally", - "find", - "lastly", - "interactions", - "designing", - "structure", - "diversity", - "networks", - "building", - "novel", - "porous", - "like", - "aim", - "strategies", + "framework", + "protein", "adjusting", - "suggesting", - "integrate", - "unique", - "produce", - "modulate", - "straightforward", - "pore", - "number", - "strongly", - "advanced", - "simple", - "simpler", - "materials", - "structures", - "complexity", - "essential", - "representing", - "assembly", - "size", "significantly", - "additional", - "indirectly", - "predictably", - "properties", "rapid", - "framework", - "data", - "accelerate", + "predicting", + "essential", + "networks", + "straightforward", + "hindered", + "predictors", "expected", - "amino", - "identity", - "frameworks", + "weak", + "predictably", + "using", + "correlating", + "complex", + "indirectly", + "conjugated", + "influences", + "residues", "factors", - 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"correlating" + "dimension", + "novel", + "advanced" ], "release_date":"2024-08-07", "publication":"\"Diverse Proteomimetic Frameworks via Rational Design of pi-Stacking Peptide Tectons\", J.Am.Chem.Soc., 146, 22236-22246", @@ -935706,112 +939844,112 @@ "synthetic construct" ], "keywords":[ + "polyaromatic", + "tectons", "tune", - "conjugated", - "architecture", + "development", + "additional", + "number", + "polarity", + "single", + "rationally", "intermolecular", - "influences", + "pore", + "elongation", "acid", - "peptide", - "including", - "shapes", - "tuning", - "generally", - "find", - "lastly", - "interactions", - "designing", - "structure", - "diversity", - "networks", - "building", - "novel", - "porous", - "like", - "aim", - "strategies", + "framework", + "protein", "adjusting", - "suggesting", - "integrate", - "unique", - "produce", - "modulate", - "straightforward", - "pore", - "number", - "strongly", - "advanced", - "simple", - "simpler", - "materials", - "structures", - "complexity", - 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"conjugated", - "architecture", + "development", + "additional", + "number", + "polarity", + "single", + "rationally", "intermolecular", - "influences", + "pore", + "elongation", "acid", - "peptide", - "including", - "shapes", - "tuning", - "generally", - "find", - "lastly", - "interactions", - "designing", - "structure", - "diversity", - "networks", - "building", - "novel", - "porous", - "like", - "aim", - "strategies", + "framework", + "protein", "adjusting", - "suggesting", - "integrate", - "unique", - "produce", - "modulate", - "straightforward", - "pore", - "number", - "strongly", - "advanced", - "simple", - "simpler", - "materials", - "structures", - "complexity", - "essential", - "representing", - "assembly", - "size", "significantly", - "additional", - "indirectly", - "predictably", - "properties", "rapid", - "framework", - "data", - "accelerate", + "predicting", + "essential", + "networks", + "straightforward", + "hindered", + "predictors", "expected", - "amino", - "identity", - 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"groups", - "also", - "predictors", - "single", - "driven", - "sizes", "peptides", - "appears", - "residues", + "capabilities", "mesoporous", - "tectons", - "guidelines", + "unique", + "assemblies", + "materials", "mechanism", - "protein", - "complex", - "development", - "case", + "engineer", + "crystallographic", + "accelerate", + "aim", + "could", + "strategies", + "geometry", + "structures", + "detailed", + "structure", + "report", + "shape", + "interactions", + "guidelines", + "tuning", + "find", + "lastly", + "appears", + "despite", + "data", "create", - "correlating" + "dimension", + "novel", + "advanced" ], "release_date":"2024-08-07", "publication":"\"Diverse Proteomimetic Frameworks via Rational Design of pi-Stacking Peptide Tectons\", J.Am.Chem.Soc., 146, 22236-22246", @@ -936144,112 +940282,112 @@ "synthetic construct" ], "keywords":[ + "polyaromatic", + "tectons", "tune", - "conjugated", - "architecture", + "development", + "additional", + "number", + "polarity", + "single", + "rationally", "intermolecular", - "influences", + "pore", + "elongation", "acid", - "peptide", - "including", - "shapes", - "tuning", - "generally", - "find", - "lastly", - "interactions", - "designing", - "structure", - "diversity", - "networks", - "building", - "novel", - "porous", - "like", - "aim", - "strategies", + "framework", + "protein", "adjusting", - "suggesting", - "integrate", - "unique", - "produce", - "modulate", - "straightforward", - "pore", - "number", - "strongly", - "advanced", - "simple", - "simpler", - "materials", - "structures", - "complexity", - "essential", - "representing", - "assembly", - "size", "significantly", - "additional", - "indirectly", - "predictably", - "properties", "rapid", - "framework", - "data", - "accelerate", + "predicting", + "essential", + "networks", + "straightforward", + "hindered", + "predictors", "expected", - "amino", - "identity", - "frameworks", + "weak", + "predictably", + "using", + "correlating", + "complex", + "indirectly", + "conjugated", + "influences", + "residues", "factors", - 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"guidelines", + "unique", + "assemblies", + "materials", "mechanism", - "protein", - "complex", - "development", - "case", + "engineer", + "crystallographic", + "accelerate", + "aim", + "could", + "strategies", + "geometry", + "structures", + "detailed", + "structure", + "report", + "shape", + "interactions", + "guidelines", + "tuning", + "find", + "lastly", + "appears", + "despite", + "data", "create", - "correlating" + "dimension", + "novel", + "advanced" ], "release_date":"2024-08-07", "publication":"\"Diverse Proteomimetic Frameworks via Rational Design of pi-Stacking Peptide Tectons\", J.Am.Chem.Soc., 146, 22236-22246", @@ -936367,112 +940505,112 @@ "synthetic construct" ], "keywords":[ + "polyaromatic", + "tectons", "tune", - "conjugated", - "architecture", + "development", + "additional", + "number", + "polarity", + "single", + "rationally", "intermolecular", - "influences", + "pore", + "elongation", "acid", - "peptide", - "including", - "shapes", - "tuning", - "generally", - "find", - "lastly", - "interactions", - "designing", - "structure", - "diversity", - "networks", - "building", - "novel", - "porous", - "like", - "aim", - "strategies", + "framework", + "protein", "adjusting", - "suggesting", - "integrate", - "unique", - "produce", - "modulate", - "straightforward", - "pore", - "number", - "strongly", - "advanced", - "simple", - "simpler", - "materials", - "structures", - "complexity", - "essential", - "representing", - "assembly", - "size", "significantly", - "additional", - "indirectly", - "predictably", - "properties", "rapid", - "framework", - "data", - "accelerate", + "predicting", + "essential", + "networks", + "straightforward", + "hindered", + "predictors", "expected", - "amino", - "identity", - "frameworks", + "weak", + "predictably", + "using", + "correlating", + "complex", + "indirectly", + "conjugated", + "influences", + "residues", "factors", - "assemblies", - "geometry", + "frameworks", + "occur", + "case", + "integrate", + "strongly", + "representing", + "blocks", + "generally", "remarkable", - "report", - "dimension", - "detailed", - "shape", - "elongation", + "size", + "architecture", "growing", - "engineer", - "polarity", - "blocks", - "crystallographic", - "predicting", - "rationally", - "using", - "weak", - "occur", - "insertion", - "sequence", + "shapes", + "modulate", + "suggesting", + "like", + "including", + "peptide", "difficulty", - "could", + "designing", + "identity", + "simpler", + "simple", + "produce", + "assembly", + "properties", + "sizes", + "porous", + "diversity", + "also", + "driven", + "groups", + "insertion", + "complexity", + "amino", "notably", - "hindered", - "polyaromatic", + "building", + "sequence", "angle", - "capabilities", - "despite", "jumps", - "groups", - "also", - "predictors", - "single", - "driven", - "sizes", "peptides", - "appears", - "residues", + "capabilities", "mesoporous", - "tectons", - "guidelines", + "unique", + "assemblies", + "materials", "mechanism", - "protein", - "complex", - "development", - "case", + "engineer", + "crystallographic", + "accelerate", + "aim", + "could", + "strategies", + "geometry", + "structures", + "detailed", + "structure", + "report", + "shape", + "interactions", + "guidelines", + "tuning", + "find", + "lastly", + "appears", + "despite", + "data", "create", - "correlating" + "dimension", + "novel", + "advanced" ], "release_date":"2024-08-07", "publication":"\"Diverse Proteomimetic Frameworks via Rational Design of pi-Stacking Peptide Tectons\", J.Am.Chem.Soc., 146, 22236-22246", @@ -936590,112 +940728,112 @@ "synthetic construct" ], "keywords":[ + "polyaromatic", + "tectons", "tune", - "conjugated", - "architecture", + "development", + "additional", + "number", + "polarity", + "single", + "rationally", "intermolecular", - "influences", + "pore", + "elongation", "acid", - "peptide", - "including", - "shapes", - "tuning", - "generally", - "find", - "lastly", - "interactions", - "designing", - "structure", - "diversity", - "networks", - "building", - "novel", - "porous", - "like", - "aim", - "strategies", + "framework", + "protein", "adjusting", - "suggesting", - "integrate", - "unique", - "produce", - "modulate", - "straightforward", - "pore", - "number", - "strongly", - "advanced", - "simple", - "simpler", - "materials", - "structures", - "complexity", - "essential", - "representing", - "assembly", - "size", "significantly", - "additional", - "indirectly", - "predictably", - "properties", "rapid", - "framework", - "data", - "accelerate", + "predicting", + "essential", + "networks", + "straightforward", + "hindered", + "predictors", "expected", - "amino", - "identity", - "frameworks", + "weak", + "predictably", + "using", + "correlating", + "complex", + "indirectly", + "conjugated", + "influences", + "residues", "factors", - "assemblies", - "geometry", + "frameworks", + "occur", + "case", + "integrate", + "strongly", + "representing", + "blocks", + "generally", "remarkable", - "report", - "dimension", - "detailed", - "shape", - "elongation", + "size", + "architecture", "growing", - "engineer", - "polarity", - "blocks", - "crystallographic", - "predicting", - "rationally", - "using", - "weak", - "occur", - "insertion", - "sequence", + "shapes", + "modulate", + "suggesting", + "like", + "including", + "peptide", "difficulty", - "could", + "designing", + "identity", + "simpler", + "simple", + "produce", + "assembly", + "properties", + "sizes", + "porous", + "diversity", + "also", + "driven", + "groups", + "insertion", + "complexity", + "amino", "notably", - "hindered", - "polyaromatic", + "building", + "sequence", "angle", - "capabilities", - "despite", "jumps", - "groups", - "also", - "predictors", - "single", - "driven", - "sizes", "peptides", - "appears", - "residues", + "capabilities", "mesoporous", - "tectons", - "guidelines", + "unique", + "assemblies", + "materials", "mechanism", - "protein", - "complex", - "development", - "case", + "engineer", + "crystallographic", + "accelerate", + "aim", + "could", + "strategies", + "geometry", + "structures", + "detailed", + "structure", + "report", + "shape", + "interactions", + "guidelines", + "tuning", + "find", + "lastly", + "appears", + "despite", + "data", "create", - "correlating" + "dimension", + "novel", + "advanced" ], "release_date":"2024-08-07", "publication":"\"Diverse Proteomimetic Frameworks via Rational Design of pi-Stacking Peptide Tectons\", J.Am.Chem.Soc., 146, 22236-22246", @@ -936802,123 +940940,123 @@ ], "subtitle":"Crystal structure of the reconstruction of the ancestral triosephosphate isomerase of the last opisthokont common ancestor obtained by maximum likelihood", "tags":[ - "triose phosphate isomerase", + "isomerase", "ancestral sequence reconstruction", - "isomerase" + "triose phosphate isomerase" ], "keywords":[ - "work", - "tims", - "analysis", - "evolution", - "unfolding", - "lineages", - "evidence", - "oligomers", - "monomeric", - "located", - "part", - "bonds", - "conserved", - "test", - "isomerase", - "physicochemical", "opisthokonts", - "protozoan", - "reconstruction", - "sequences", - "robustness", - "equilibrium", - "structure", - "monomer", - "applied", - "oligomer", - "resembles", - "unstable", - "spectroscopic", + "tot", + "hydrodynamic", + "well", + "opisthokonta", + "presence", + "differences", + "bottom", + "locatims", "locatim", - "structured", - "reversible", - "resembling", - "reached", - "similar", - "infer", - "obligated", - "calorimetric", + "unstable", + "parameters", + "resembles", + "physicochemical", + "study", "indicated", - "although", - "strongly", - "locatims", - "presence", - "used", - "ancestral", - "comparative", - "structures", - "transitions", - "function", + "unfolding", "showed", - "triosephosphate", - "intermediates", + "equilibrium", "extensive", + "test", + "catalytic", + "two", + "infer", + "lineages", + "similar", + "worst", + "reconstructed", "shows", - "coupled", + "conformational", + "isomerase", + "ones", + "intermediates", + "although", + "last", + "case", + "strongly", + "triosephosphate", + "stability", + "part", + "evidence", + "characterization", + "several", + "ancestral", "hydrogen", "inference", - "properties", - "previously", - "stability", - "monomers", - "bottom", + "found", + "reached", + "\u03b4g", + "resembling", + "evolution", "higher", - "common", - "worst", - "methodologies", - "catalytic", - "temperature", - "four", - "unf", "diverged", - "observed", - "several", - "melting", - "characterization", - "confidence", - "rather", - "\u03b4g", - "high", - "sequence", - "parameters", + "robustness", + "four", + "monomer", + "barrel", + "correlation", "increase", + "spectroscopic", + "calorimetric", + "work", + "used", "extant", - "notably", - "ancestor", - "ones", - "tim", - "hydrodynamic", + "different", + "transitions", + "monomers", + "properties", + "bonds", + "also", + "reversible", + "confidence", + "inactive", + "methodologies", + "oligomer", + "unf", "plausible", + "notably", + "sequence", + "applied", + "common", "3d", - "opisthokonta", - "conformational", - "estimated", - "also", - "study", + "analysis", + "coupled", + "sequences", + "comparative", + "conserved", + "rather", + "observed", + "structures", + "reconstruction", + "oligomers", + "previously", + "structured", + "structure", + "monomeric", "fungi", - "barrel", - "tot", - "well", - "last", - "different", - "found", - "two", - "reconstructed", - "inactive", + "scenario", + "temperature", + "biophysical", + "function", + "melting", + "obligated", "energetics", + "located", + "high", + "estimated", + "tim", + "tims", + "ancestor", "animals", - "differences", - "scenario", - "case", - "correlation", - "biophysical" + "protozoan" ], "release_date":"2024-09-04", "publication":"\"Stable monomers in the ancestral sequence reconstruction of the last opisthokont common ancestor of dimeric triosephosphate isomerase\", Protein Sci., 33, e5134-e5134", @@ -936955,19 +941093,19 @@ }, { "sim":520.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":520.0, - "partner":"8w08" + "partner":"8v0a" }, { "sim":496.0, - "partner":"8v2w" + "partner":"8v09" }, { "sim":496.0, - "partner":"8v09" + "partner":"8v2w" }, { "sim":485.0, @@ -936987,11 +941125,11 @@ }, { "sim":51.0, - "partner":"8c66" + "partner":"8adx" }, { "sim":51.0, - "partner":"8adx" + "partner":"8c66" }, { "sim":50.0, @@ -937093,11 +941231,11 @@ }, { "sim":341.0, - "partner":"8tim" + "partner":"1tph" }, { "sim":341.0, - "partner":"1tph" + "partner":"8tim" }, { "sim":341.0, @@ -937149,23 +941287,23 @@ }, { "sim":339.0, - "partner":"1r2s" + "partner":"4owg" }, { "sim":339.0, - "partner":"1r2t" + "partner":"1r2r" }, { "sim":339.0, - "partner":"4owg" + "partner":"1hti" }, { "sim":339.0, - "partner":"1hti" + "partner":"1r2s" }, { "sim":339.0, - "partner":"1r2r" + "partner":"1r2t" }, { "sim":339.0, @@ -937285,27 +941423,27 @@ }, { "sim":313.0, - "partner":"8j7c" + "partner":"4gnj" }, { "sim":313.0, - "partner":"8jbp" + "partner":"8j7c" }, { "sim":313.0, - "partner":"4gnj" + "partner":"8jbp" }, { "sim":307.0, - "partner":"2ypi" + "partner":"1ypi" }, { "sim":307.0, - "partner":"1ypi" + "partner":"7tim" }, { "sim":307.0, - "partner":"7tim" + "partner":"2ypi" }, { "sim":305.0, @@ -937321,11 +941459,11 @@ }, { "sim":299.0, - "partner":"1nf0" + "partner":"1ney" }, { "sim":299.0, - "partner":"1ney" + "partner":"1nf0" }, { "sim":295.0, @@ -937353,11 +941491,11 @@ }, { "sim":290.0, - "partner":"4o50" + "partner":"4o57" }, { "sim":290.0, - "partner":"4o57" + "partner":"4o50" }, { "sim":290.0, @@ -937385,51 +941523,51 @@ }, { "sim":277.0, - "partner":"7az3" + "partner":"1n55" }, { "sim":277.0, - "partner":"2vxn" + "partner":"7az9" }, { "sim":277.0, - "partner":"7az4" + "partner":"7aza" }, { "sim":277.0, - "partner":"1n55" + "partner":"2y61" }, { "sim":277.0, - "partner":"7az9" + "partner":"2y62" }, { "sim":277.0, - "partner":"7aza" + "partner":"2y63" }, { "sim":277.0, - "partner":"2y61" + "partner":"7abx" }, { "sim":277.0, - "partner":"2y62" + "partner":"7az3" }, { "sim":277.0, - "partner":"2y63" + "partner":"1qds" }, { "sim":277.0, - "partner":"1if2" + "partner":"7az4" }, { "sim":277.0, - "partner":"7abx" + "partner":"1if2" }, { "sim":277.0, - "partner":"1qds" + "partner":"2vxn" }, { "sim":276.0, @@ -937463,10 +941601,6 @@ "sim":271.0, "partner":"1iig" }, - { - "sim":271.0, - "partner":"2v0t" - }, { "sim":271.0, "partner":"1iih" @@ -937477,11 +941611,11 @@ }, { "sim":271.0, - "partner":"1ag1" + "partner":"2oma" }, { "sim":271.0, - "partner":"2oma" + "partner":"1ag1" }, { "sim":271.0, @@ -937501,15 +941635,19 @@ }, { "sim":271.0, - "partner":"4tim" + "partner":"2v0t" }, { "sim":271.0, - "partner":"2v5l" + "partner":"6tim" }, { "sim":271.0, - "partner":"6tim" + "partner":"4tim" + }, + { + "sim":271.0, + "partner":"2v5l" }, { "sim":271.0, @@ -937565,7 +941703,7 @@ }, { "sim":268.0, - "partner":"1kv5" + "partner":"5i3f" }, { "sim":268.0, @@ -937573,7 +941711,7 @@ }, { "sim":268.0, - "partner":"5i3f" + "partner":"1kv5" }, { "sim":268.0, @@ -937601,19 +941739,15 @@ }, { "sim":261.0, - "partner":"2vfd" + "partner":"4ywi" }, { "sim":261.0, - "partner":"2vfe" + "partner":"2vfd" }, { "sim":261.0, - "partner":"4ywi" - }, - { - "sim":260.0, - "partner":"1lzo" + "partner":"2vfe" }, { "sim":260.0, @@ -937639,6 +941773,10 @@ "sim":260.0, "partner":"1m7o" }, + { + "sim":260.0, + "partner":"1lzo" + }, { "sim":260.0, "partner":"1m7p" @@ -937665,31 +941803,31 @@ }, { "sim":258.0, - "partner":"5gv4" + "partner":"2vff" }, { "sim":258.0, - "partner":"5gzp" + "partner":"5bmw" }, { "sim":258.0, - "partner":"2vff" + "partner":"2vfg" }, { "sim":258.0, - "partner":"5bmw" + "partner":"4zz9" }, { "sim":258.0, - "partner":"2vfg" + "partner":"5bnk" }, { "sim":258.0, - "partner":"4zz9" + "partner":"5gzp" }, { "sim":258.0, - "partner":"5bnk" + "partner":"5gv4" }, { "sim":257.0, @@ -937831,10 +941969,6 @@ "sim":228.0, "partner":"4pcf" }, - { - "sim":228.0, - "partner":"3uwz" - }, { "sim":228.0, "partner":"3uwu" @@ -937851,6 +941985,10 @@ "sim":228.0, "partner":"3uwy" }, + { + "sim":228.0, + "partner":"3uwz" + }, { "sim":226.0, "partner":"4y96" @@ -938109,43 +942247,39 @@ }, { "sim":55.0, - "partner":"5y0f" - }, - { - "sim":55.0, - "partner":"5y0g" + "partner":"4nns" }, { "sim":55.0, - "partner":"4nns" + "partner":"4nnt" }, { "sim":55.0, - "partner":"4nnt" + "partner":"6ljs" }, { "sim":55.0, - "partner":"5y12" + "partner":"6ljt" }, { "sim":55.0, - "partner":"6ljs" + "partner":"8wdx" }, { "sim":55.0, - "partner":"5d45" + "partner":"5y12" }, { "sim":55.0, - "partner":"5y13" + "partner":"6lju" }, { "sim":55.0, - "partner":"6ljt" + "partner":"5d45" }, { "sim":55.0, - "partner":"6lju" + "partner":"5y13" }, { "sim":55.0, @@ -938169,7 +942303,7 @@ }, { "sim":55.0, - "partner":"8wdx" + "partner":"8we3" }, { "sim":55.0, @@ -938181,11 +942315,15 @@ }, { "sim":55.0, - "partner":"8we3" + "partner":"5y0x" }, { "sim":55.0, - "partner":"5y0x" + "partner":"5y0f" + }, + { + "sim":55.0, + "partner":"5y0g" }, { "sim":55.0, @@ -938299,10 +942437,6 @@ "sim":54.0, "partner":"1nyn" }, - { - "sim":54.0, - "partner":"5zrk" - }, { "sim":54.0, "partner":"5zrl" @@ -938331,6 +942465,10 @@ "sim":54.0, "partner":"5zri" }, + { + "sim":54.0, + "partner":"5zrk" + }, { "sim":54.0, "partner":"3rsw" @@ -938365,11 +942503,11 @@ }, { "sim":54.0, - "partner":"3th5" + "partner":"4gzl" }, { "sim":54.0, - "partner":"4gzl" + "partner":"3th5" }, { "sim":54.0, @@ -938405,19 +942543,19 @@ }, { "sim":54.0, - "partner":"8vip" + "partner":"8vit" }, { "sim":54.0, - "partner":"8viq" + "partner":"8vip" }, { "sim":54.0, - "partner":"8vir" + "partner":"8viq" }, { "sim":54.0, - "partner":"8vit" + "partner":"8vir" }, { "sim":54.0, @@ -938487,10 +942625,6 @@ "sim":54.0, "partner":"5xix" }, - { - "sim":54.0, - "partner":"2cj9" - }, { "sim":54.0, "partner":"2cja" @@ -938503,6 +942637,10 @@ "sim":54.0, "partner":"2cjb" }, + { + "sim":54.0, + "partner":"2cj9" + }, { "sim":53.0, "partner":"2jve" @@ -938609,15 +942747,15 @@ }, { "sim":53.0, - "partner":"6j0l" + "partner":"6j0g" }, { "sim":53.0, - "partner":"6j0g" + "partner":"6j0k" }, { "sim":53.0, - "partner":"6j0k" + "partner":"6j0l" }, { "sim":53.0, @@ -938641,23 +942779,23 @@ }, { "sim":53.0, - "partner":"6ihr" + "partner":"6ihv" }, { "sim":53.0, - "partner":"6iht" + "partner":"6ihw" }, { "sim":53.0, - "partner":"6ihu" + "partner":"6ihr" }, { "sim":53.0, - "partner":"6ihv" + "partner":"6iht" }, { "sim":53.0, - "partner":"6ihw" + "partner":"6ihu" }, { "sim":53.0, @@ -938725,11 +942863,11 @@ }, { "sim":53.0, - "partner":"3la8" + "partner":"3lba" }, { "sim":53.0, - "partner":"3lba" + "partner":"3la8" }, { "sim":53.0, @@ -938747,10 +942885,6 @@ "sim":53.0, "partner":"6jtz" }, - { - "sim":53.0, - "partner":"3pz9" - }, { "sim":53.0, "partner":"3pzg" @@ -938775,6 +942909,10 @@ "sim":53.0, "partner":"3pzq" }, + { + "sim":53.0, + "partner":"3pz9" + }, { "sim":53.0, "partner":"3fvm" @@ -938837,15 +942975,15 @@ }, { "sim":53.0, - "partner":"7mdl" + "partner":"8g9z" }, { "sim":53.0, - "partner":"8g9z" + "partner":"7l1t" }, { "sim":53.0, - "partner":"7l1t" + "partner":"7mdl" }, { "sim":53.0, @@ -938869,11 +943007,11 @@ }, { "sim":53.0, - "partner":"2vbg" + "partner":"2vbf" }, { "sim":53.0, - "partner":"2vbf" + "partner":"2vbg" }, { "sim":53.0, @@ -938957,15 +943095,15 @@ }, { "sim":52.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":52.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":52.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":52.0, @@ -939005,19 +943143,19 @@ }, { "sim":52.0, - "partner":"1x24" + "partner":"4gzd" }, { "sim":52.0, - "partner":"4gzc" + "partner":"1zcl" }, { "sim":52.0, - "partner":"4gzd" + "partner":"1x24" }, { "sim":52.0, - "partner":"1zcl" + "partner":"4gzc" }, { "sim":52.0, @@ -939049,11 +943187,11 @@ }, { "sim":52.0, - "partner":"6kz6" + "partner":"8be9" }, { "sim":52.0, - "partner":"8be9" + "partner":"6kz6" }, { "sim":52.0, @@ -939091,10 +943229,6 @@ "sim":52.0, "partner":"3vwv" }, - { - "sim":52.0, - "partner":"3l1u" - }, { "sim":52.0, "partner":"3l1v" @@ -939111,6 +943245,10 @@ "sim":52.0, "partner":"3esr" }, + { + "sim":52.0, + "partner":"3l1u" + }, { "sim":52.0, "partner":"2kn6" @@ -939145,19 +943283,19 @@ }, { "sim":52.0, - "partner":"4bmx" + "partner":"4bmz" }, { "sim":52.0, - "partner":"4bmy" + "partner":"4bn0" }, { "sim":52.0, - "partner":"4bmz" + "partner":"4bmx" }, { "sim":52.0, - "partner":"4bn0" + "partner":"4bmy" }, { "sim":52.0, @@ -939235,10 +943373,6 @@ "sim":52.0, "partner":"6l86" }, - { - "sim":52.0, - "partner":"5mit" - }, { "sim":52.0, "partner":"5mjk" @@ -939263,6 +943397,10 @@ "sim":52.0, "partner":"5mis" }, + { + "sim":52.0, + "partner":"5mit" + }, { "sim":52.0, "partner":"2yhw" @@ -939289,11 +943427,11 @@ }, { "sim":52.0, - "partner":"7js3" + "partner":"8g5w" }, { "sim":52.0, - "partner":"8g5w" + "partner":"7js3" }, { "sim":52.0, @@ -939331,10 +943469,6 @@ "sim":52.0, "partner":"4rhq" }, - { - "sim":52.0, - "partner":"5g6t" - }, { "sim":52.0, "partner":"5g5u" @@ -939361,7 +943495,7 @@ }, { "sim":52.0, - "partner":"7ajm" + "partner":"5g6t" }, { "sim":52.0, @@ -939381,15 +943515,15 @@ }, { "sim":52.0, - "partner":"5jyf" + "partner":"7ajm" }, { "sim":52.0, - "partner":"8phd" + "partner":"5v8x" }, { "sim":52.0, - "partner":"5v8x" + "partner":"8phv" }, { "sim":52.0, @@ -939399,6 +943533,10 @@ "sim":52.0, "partner":"5utl" }, + { + "sim":52.0, + "partner":"8phd" + }, { "sim":52.0, "partner":"5utm" @@ -939417,27 +943555,7 @@ }, { "sim":52.0, - "partner":"8phv" - }, - { - "sim":52.0, - "partner":"7a53" - }, - { - "sim":52.0, - "partner":"7ajw" - }, - { - "sim":52.0, - "partner":"7akb" - }, - { - "sim":52.0, - "partner":"7ajy" - }, - { - "sim":52.0, - "partner":"7a5l" + "partner":"5jyf" }, { "sim":52.0, @@ -939499,22 +943617,42 @@ "sim":52.0, "partner":"7aka" }, + { + "sim":52.0, + "partner":"7a53" + }, { "sim":52.0, "partner":"7akl" }, { "sim":52.0, - "partner":"8wov" + "partner":"7ajw" }, { "sim":52.0, - "partner":"8wow" + "partner":"7akb" + }, + { + "sim":52.0, + "partner":"7ajy" + }, + { + "sim":52.0, + "partner":"7a5l" }, { "sim":52.0, "partner":"8wop" }, + { + "sim":52.0, + "partner":"8wov" + }, + { + "sim":52.0, + "partner":"8wow" + }, { "sim":52.0, "partner":"4rl1" @@ -939635,10 +943773,6 @@ "sim":51.0, "partner":"1te4" }, - { - "sim":51.0, - "partner":"4hmr" - }, { "sim":51.0, "partner":"4hls" @@ -939651,6 +943785,10 @@ "sim":51.0, "partner":"1yx3" }, + { + "sim":51.0, + "partner":"4hmr" + }, { "sim":51.0, "partner":"6l8p" @@ -939811,10 +943949,6 @@ "sim":51.0, "partner":"6a4c" }, - { - "sim":51.0, - "partner":"6ueo" - }, { "sim":51.0, "partner":"6uep" @@ -939827,6 +943961,10 @@ "sim":51.0, "partner":"6uer" }, + { + "sim":51.0, + "partner":"6ueo" + }, { "sim":51.0, "partner":"3wyd" @@ -939853,16 +943991,12 @@ }, { "sim":51.0, - "partner":"7o2t" + "partner":"6z17" }, { "sim":51.0, "partner":"7o2u" }, - { - "sim":51.0, - "partner":"6z17" - }, { "sim":51.0, "partner":"6yz3" @@ -939879,6 +944013,10 @@ "sim":51.0, "partner":"6z5k" }, + { + "sim":51.0, + "partner":"7o2t" + }, { "sim":51.0, "partner":"1zw9" @@ -939955,14 +944093,6 @@ "sim":51.0, "partner":"6azo" }, - { - "sim":51.0, - "partner":"8wbk" - }, - { - "sim":51.0, - "partner":"8wbl" - }, { "sim":51.0, "partner":"8wbm" @@ -939985,20 +944115,28 @@ }, { "sim":51.0, - "partner":"6ubb" + "partner":"8wbk" }, { "sim":51.0, - "partner":"6ihs" + "partner":"8wbl" }, { "sim":51.0, "partner":"6ub8" }, + { + "sim":51.0, + "partner":"6ubb" + }, { "sim":51.0, "partner":"6uba" }, + { + "sim":51.0, + "partner":"6ihs" + }, { "sim":51.0, "partner":"4ag0" @@ -940013,11 +944151,11 @@ }, { "sim":51.0, - "partner":"5c2d" + "partner":"6dli" }, { "sim":51.0, - "partner":"6dli" + "partner":"5c2d" }, { "sim":51.0, @@ -940039,14 +944177,6 @@ "sim":51.0, "partner":"5vrc" }, - { - "sim":51.0, - "partner":"3quo" - }, - { - "sim":51.0, - "partner":"3qvf" - }, { "sim":51.0, "partner":"3qur" @@ -940075,6 +944205,14 @@ "sim":51.0, "partner":"3qun" }, + { + "sim":51.0, + "partner":"3quo" + }, + { + "sim":51.0, + "partner":"3qvf" + }, { "sim":51.0, "partner":"3jyy" @@ -940123,10 +944261,6 @@ "sim":51.0, "partner":"3v91" }, - { - "sim":51.0, - "partner":"6wye" - }, { "sim":51.0, "partner":"2jfo" @@ -940147,6 +944281,10 @@ "sim":51.0, "partner":"4ats" }, + { + "sim":51.0, + "partner":"6wye" + }, { "sim":51.0, "partner":"7umj" @@ -940165,11 +944303,11 @@ }, { "sim":51.0, - "partner":"6aa8" + "partner":"7eov" }, { "sim":51.0, - "partner":"7eov" + "partner":"6aa8" }, { "sim":51.0, @@ -940179,10 +944317,6 @@ "sim":51.0, "partner":"5dz7" }, - { - "sim":51.0, - "partner":"8wlb" - }, { "sim":51.0, "partner":"8wl5" @@ -940195,6 +944329,10 @@ "sim":51.0, "partner":"8wl9" }, + { + "sim":51.0, + "partner":"8wlb" + }, { "sim":51.0, "partner":"3zgc" @@ -940217,51 +944355,51 @@ }, { "sim":51.0, - "partner":"7q2b" + "partner":"7q2f" }, { "sim":51.0, - "partner":"3ha3" + "partner":"7q2g" }, { "sim":51.0, - "partner":"7q2c" + "partner":"7q2h" }, { "sim":51.0, - "partner":"7q2d" + "partner":"3ha5" }, { "sim":51.0, - "partner":"7q2e" + "partner":"2fk7" }, { "sim":51.0, - "partner":"7q2f" + "partner":"2fk8" }, { "sim":51.0, - "partner":"7q2g" + "partner":"3ha7" }, { "sim":51.0, - "partner":"7q2h" + "partner":"7q2b" }, { "sim":51.0, - "partner":"3ha5" + "partner":"7q2c" }, { "sim":51.0, - "partner":"2fk7" + "partner":"3ha3" }, { "sim":51.0, - "partner":"2fk8" + "partner":"7q2d" }, { "sim":51.0, - "partner":"3ha7" + "partner":"7q2e" }, { "sim":51.0, @@ -940357,31 +944495,31 @@ }, { "sim":51.0, - "partner":"4w7v" + "partner":"7f8d" }, { "sim":51.0, - "partner":"4w7w" + "partner":"7by8" }, { "sim":51.0, - "partner":"7f8d" + "partner":"7by9" }, { "sim":51.0, - "partner":"7by8" + "partner":"7bya" }, { "sim":51.0, - "partner":"7by9" + "partner":"4w7u" }, { "sim":51.0, - "partner":"7bya" + "partner":"4w7v" }, { "sim":51.0, - "partner":"4w7u" + "partner":"4w7w" }, { "sim":51.0, @@ -940435,14 +944573,6 @@ "sim":51.0, "partner":"4hbk" }, - { - "sim":51.0, - "partner":"4fif" - }, - { - "sim":51.0, - "partner":"7s46" - }, { "sim":51.0, "partner":"4fig" @@ -940493,11 +944623,11 @@ }, { "sim":51.0, - "partner":"6sf5" + "partner":"4fif" }, { "sim":51.0, - "partner":"7dw8" + "partner":"7s46" }, { "sim":51.0, @@ -940521,19 +944651,23 @@ }, { "sim":51.0, - "partner":"3ren" + "partner":"6sf5" }, { "sim":51.0, - "partner":"8fbx" + "partner":"7dw8" }, { "sim":51.0, - "partner":"5xm6" + "partner":"3ren" }, { "sim":51.0, - "partner":"2ikf" + "partner":"8fbx" + }, + { + "sim":51.0, + "partner":"5xm6" }, { "sim":51.0, @@ -940587,6 +944721,10 @@ "sim":51.0, "partner":"5kal" }, + { + "sim":51.0, + "partner":"2ikf" + }, { "sim":51.0, "partner":"6nxc" @@ -940607,10 +944745,6 @@ "sim":51.0, "partner":"2him" }, - { - "sim":51.0, - "partner":"1vsu" - }, { "sim":51.0, "partner":"1vsv" @@ -940667,6 +944801,10 @@ "sim":51.0, "partner":"3m5c" }, + { + "sim":51.0, + "partner":"1vsu" + }, { "sim":51.0, "partner":"3m5d" @@ -940687,10 +944825,6 @@ "sim":51.0, "partner":"7us5" }, - { - "sim":51.0, - "partner":"4m1i" - }, { "sim":51.0, "partner":"4d8f" @@ -940705,47 +944839,51 @@ }, { "sim":51.0, - "partner":"7wxl" + "partner":"4m1i" }, { "sim":51.0, - "partner":"7wxm" + "partner":"7wxp" }, { "sim":51.0, - "partner":"7wxn" + "partner":"7wxq" }, { "sim":51.0, - "partner":"7wxo" + "partner":"7wxr" }, { "sim":51.0, - "partner":"7wxp" + "partner":"7xte" }, { "sim":51.0, - "partner":"7wxq" + "partner":"7xtf" }, { "sim":51.0, - "partner":"7wxr" + "partner":"7wxj" }, { "sim":51.0, - "partner":"7xte" + "partner":"7wxk" }, { "sim":51.0, - "partner":"7xtf" + "partner":"7wxl" }, { "sim":51.0, - "partner":"7wxj" + "partner":"7wxm" }, { "sim":51.0, - "partner":"7wxk" + "partner":"7wxn" + }, + { + "sim":51.0, + "partner":"7wxo" }, { "sim":51.0, @@ -940783,17 +944921,13 @@ "sim":51.0, "partner":"3wnd" }, - { - "sim":51.0, - "partner":"5f5m" - }, { "sim":51.0, "partner":"5f5o" }, { "sim":51.0, - "partner":"3c1y" + "partner":"5f5m" }, { "sim":51.0, @@ -940821,7 +944955,7 @@ }, { "sim":51.0, - "partner":"4zhs" + "partner":"3c1y" }, { "sim":51.0, @@ -940849,19 +944983,19 @@ }, { "sim":51.0, - "partner":"4ltz" + "partner":"4zhs" }, { "sim":51.0, - "partner":"7kj8" + "partner":"3kbk" }, { "sim":51.0, - "partner":"7kj9" + "partner":"6ax9" }, { "sim":51.0, - "partner":"3kbk" + "partner":"7kjd" }, { "sim":51.0, @@ -940869,7 +945003,7 @@ }, { "sim":51.0, - "partner":"6ax9" + "partner":"7kje" }, { "sim":51.0, @@ -940877,39 +945011,31 @@ }, { "sim":51.0, - "partner":"8su2" - }, - { - "sim":51.0, - "partner":"8su3" - }, - { - "sim":51.0, - "partner":"7kjd" + "partner":"6axu" }, { "sim":51.0, - "partner":"8su4" + "partner":"7kjf" }, { "sim":51.0, - "partner":"6axu" + "partner":"8su2" }, { "sim":51.0, - "partner":"7kje" + "partner":"7kjg" }, { "sim":51.0, - "partner":"8su5" + "partner":"8su3" }, { "sim":51.0, - "partner":"7kjf" + "partner":"8v3k" }, { "sim":51.0, - "partner":"7kjg" + "partner":"8su4" }, { "sim":51.0, @@ -940917,11 +945043,11 @@ }, { "sim":51.0, - "partner":"3kb9" + "partner":"8su5" }, { "sim":51.0, - "partner":"8v3k" + "partner":"3kb9" }, { "sim":51.0, @@ -940959,6 +945085,18 @@ "sim":51.0, "partner":"4luu" }, + { + "sim":51.0, + "partner":"7kj8" + }, + { + "sim":51.0, + "partner":"4ltz" + }, + { + "sim":51.0, + "partner":"7kj9" + }, { "sim":51.0, "partner":"8sm8" @@ -940969,11 +945107,11 @@ }, { "sim":51.0, - "partner":"4wwv" + "partner":"3bu7" }, { "sim":51.0, - "partner":"3bu7" + "partner":"4wwv" }, { "sim":51.0, @@ -941015,10 +945153,6 @@ "sim":51.0, "partner":"4w61" }, - { - "sim":51.0, - "partner":"2gqn" - }, { "sim":51.0, "partner":"2fq6" @@ -941033,15 +945167,15 @@ }, { "sim":51.0, - "partner":"7bvt" + "partner":"2gqn" }, { "sim":51.0, - "partner":"5xpj" + "partner":"7bvt" }, { "sim":51.0, - "partner":"4euh" + "partner":"5xpj" }, { "sim":51.0, @@ -941053,7 +945187,7 @@ }, { "sim":51.0, - "partner":"5dvi" + "partner":"4euh" }, { "sim":51.0, @@ -941063,6 +945197,10 @@ "sim":51.0, "partner":"5dvf" }, + { + "sim":51.0, + "partner":"5dvi" + }, { "sim":51.0, "partner":"5hxk" @@ -941099,10 +945237,6 @@ "sim":51.0, "partner":"7ui4" }, - { - "sim":51.0, - "partner":"4q6q" - }, { "sim":51.0, "partner":"4q6m" @@ -941121,24 +945255,28 @@ }, { "sim":51.0, - "partner":"6v99" + "partner":"4q6q" }, { "sim":51.0, - "partner":"6v9a" + "partner":"6v96" }, { "sim":51.0, - "partner":"6v96" + "partner":"6v99" }, { "sim":51.0, - "partner":"7lr2" + "partner":"6v9a" }, { "sim":51.0, "partner":"7lr1" }, + { + "sim":51.0, + "partner":"7lr2" + }, { "sim":51.0, "partner":"5ctt" @@ -941169,28 +945307,16 @@ }, { "sim":51.0, - "partner":"6mlh" - }, - { - "sim":51.0, - "partner":"6oi8" + "partner":"6nn1" }, { "sim":51.0, - "partner":"6mlw" + "partner":"6n1e" }, { "sim":51.0, "partner":"4mv1" }, - { - "sim":51.0, - "partner":"6nn1" - }, - { - "sim":51.0, - "partner":"6n1e" - }, { "sim":51.0, "partner":"4mv3" @@ -941253,11 +945379,15 @@ }, { "sim":51.0, - "partner":"2gps" + "partner":"6mlh" }, { "sim":51.0, - "partner":"6oi9" + "partner":"6oi8" + }, + { + "sim":51.0, + "partner":"6mlw" }, { "sim":51.0, @@ -941277,20 +945407,28 @@ }, { "sim":51.0, - "partner":"6wiu" + "partner":"2gps" }, { "sim":51.0, - "partner":"8u41" + "partner":"6oi9" }, { "sim":51.0, - "partner":"8u42" + "partner":"6wiu" }, { "sim":51.0, "partner":"2fwr" }, + { + "sim":51.0, + "partner":"8u41" + }, + { + "sim":51.0, + "partner":"8u42" + }, { "sim":51.0, "partner":"8ux5" @@ -941305,15 +945443,15 @@ }, { "sim":51.0, - "partner":"6x0h" + "partner":"6x0j" }, { "sim":51.0, - "partner":"6x0j" + "partner":"6x0k" }, { "sim":51.0, - "partner":"6x0k" + "partner":"6x0h" }, { "sim":51.0, @@ -941337,15 +945475,15 @@ }, { "sim":51.0, - "partner":"4dqw" + "partner":"6gjv" }, { "sim":51.0, - "partner":"6gjv" + "partner":"6gk9" }, { "sim":51.0, - "partner":"6gk9" + "partner":"4dqw" }, { "sim":51.0, @@ -941479,10 +945617,6 @@ "sim":51.0, "partner":"4lh3" }, - { - "sim":51.0, - "partner":"5wm2" - }, { "sim":51.0, "partner":"5wm3" @@ -941503,6 +945637,10 @@ "sim":51.0, "partner":"5wm7" }, + { + "sim":51.0, + "partner":"5wm2" + }, { "sim":51.0, "partner":"3bdl" @@ -941527,10 +945665,6 @@ "sim":51.0, "partner":"5wdg" }, - { - "sim":51.0, - "partner":"6j1e" - }, { "sim":51.0, "partner":"6j1i" @@ -941543,6 +945677,10 @@ "sim":51.0, "partner":"6j0p" }, + { + "sim":51.0, + "partner":"6j1e" + }, { "sim":51.0, "partner":"6k0w" @@ -941557,11 +945695,11 @@ }, { "sim":51.0, - "partner":"3i39" + "partner":"7err" }, { "sim":51.0, - "partner":"7err" + "partner":"3i39" }, { "sim":51.0, @@ -941609,43 +945747,43 @@ }, { "sim":51.0, - "partner":"2yii" + "partner":"4c5u" }, { "sim":51.0, - "partner":"4c5s" + "partner":"4cq5" }, { "sim":51.0, - "partner":"4v2r" + "partner":"4baa" }, { "sim":51.0, - "partner":"4c5u" + "partner":"4c6g" }, { "sim":51.0, - "partner":"4cq5" + "partner":"4bab" }, { "sim":51.0, - "partner":"4baa" + "partner":"4c5r" }, { "sim":51.0, - "partner":"4c6g" + "partner":"2yii" }, { "sim":51.0, - "partner":"4bab" + "partner":"4v2q" }, { "sim":51.0, - "partner":"4c5r" + "partner":"4c5s" }, { "sim":51.0, - "partner":"4v2q" + "partner":"4v2r" }, { "sim":51.0, @@ -941693,11 +945831,11 @@ }, { "sim":51.0, - "partner":"3l7r" + "partner":"3t0c" }, { "sim":51.0, - "partner":"3t0c" + "partner":"3l7r" }, { "sim":51.0, @@ -941715,10 +945853,6 @@ "sim":51.0, "partner":"5n6u" }, - { - "sim":51.0, - "partner":"5y1h" - }, { "sim":51.0, "partner":"5y1k" @@ -941763,6 +945897,10 @@ "sim":51.0, "partner":"5y3i" }, + { + "sim":51.0, + "partner":"5y1h" + }, { "sim":51.0, "partner":"7ufr" @@ -941919,10 +946057,6 @@ "sim":50.0, "partner":"6rcx" }, - { - "sim":50.0, - "partner":"4a41" - }, { "sim":50.0, "partner":"4a44" @@ -941937,11 +946071,11 @@ }, { "sim":50.0, - "partner":"6t73" + "partner":"4a41" }, { "sim":50.0, - "partner":"2vbq" + "partner":"6t73" }, { "sim":50.0, @@ -941955,6 +946089,10 @@ "sim":50.0, "partner":"1s60" }, + { + "sim":50.0, + "partner":"2vbq" + }, { "sim":50.0, "partner":"6o20" @@ -942061,11 +946199,11 @@ }, { "sim":50.0, - "partner":"3s2s" + "partner":"3hth" }, { "sim":50.0, - "partner":"3hth" + "partner":"3s2s" }, { "sim":50.0, @@ -942081,11 +946219,11 @@ }, { "sim":50.0, - "partner":"3oci" + "partner":"3oc3" }, { "sim":50.0, - "partner":"3oc3" + "partner":"3oci" }, { "sim":50.0, @@ -942205,19 +946343,19 @@ }, { "sim":50.0, - "partner":"5tgs" + "partner":"5th5" }, { "sim":50.0, - "partner":"5th5" + "partner":"5tgs" }, { "sim":50.0, - "partner":"6t2r" + "partner":"4nec" }, { "sim":50.0, - "partner":"4nec" + "partner":"6t2r" }, { "sim":50.0, @@ -942249,11 +946387,11 @@ }, { "sim":50.0, - "partner":"6hxo" + "partner":"6hxn" }, { "sim":50.0, - "partner":"6hxn" + "partner":"6hxo" }, { "sim":50.0, @@ -942273,23 +946411,23 @@ }, { "sim":50.0, - "partner":"6fcn" + "partner":"6ypa" }, { "sim":50.0, - "partner":"2wk1" + "partner":"6akv" }, { "sim":50.0, - "partner":"6ypa" + "partner":"6fcm" }, { "sim":50.0, - "partner":"6akv" + "partner":"6fcn" }, { "sim":50.0, - "partner":"6fcm" + "partner":"2wk1" }, { "sim":50.0, @@ -942297,11 +946435,11 @@ }, { "sim":50.0, - "partner":"4rni" + "partner":"4rnj" }, { "sim":50.0, - "partner":"4rnj" + "partner":"4rni" }, { "sim":50.0, @@ -942331,10 +946469,6 @@ "sim":50.0, "partner":"4x9x" }, - { - "sim":50.0, - "partner":"3s3h" - }, { "sim":50.0, "partner":"4gxn" @@ -942361,7 +946495,7 @@ }, { "sim":50.0, - "partner":"7xif" + "partner":"3s3h" }, { "sim":50.0, @@ -942375,6 +946509,10 @@ "sim":50.0, "partner":"7xii" }, + { + "sim":50.0, + "partner":"7xif" + }, { "sim":50.0, "partner":"3doj" @@ -942401,19 +946539,19 @@ }, { "sim":50.0, - "partner":"5zmy" + "partner":"6f1w" }, { "sim":50.0, - "partner":"6f1w" + "partner":"5zmy" }, { "sim":50.0, - "partner":"5okt" + "partner":"7nzy" }, { "sim":50.0, - "partner":"7nzy" + "partner":"5okt" }, { "sim":50.0, @@ -942521,19 +946659,19 @@ }, { "sim":50.0, - "partner":"2pzm" + "partner":"2pzk" }, { "sim":50.0, - "partner":"2pzk" + "partner":"2pzl" }, { "sim":50.0, - "partner":"2pzl" + "partner":"2pzm" }, { "sim":50.0, - "partner":"6lcn" + "partner":"7bsx" }, { "sim":50.0, @@ -942541,11 +946679,11 @@ }, { "sim":50.0, - "partner":"7bsx" + "partner":"3h7r" }, { "sim":50.0, - "partner":"3h7r" + "partner":"6lcn" }, { "sim":50.0, @@ -942591,14 +946729,6 @@ "sim":50.0, "partner":"4hg5" }, - { - "sim":50.0, - "partner":"5tyq" - }, - { - "sim":50.0, - "partner":"5u19" - }, { "sim":50.0, "partner":"5u0n" @@ -942627,6 +946757,14 @@ "sim":50.0, "partner":"5u1i" }, + { + "sim":50.0, + "partner":"5tyq" + }, + { + "sim":50.0, + "partner":"5u19" + }, { "sim":50.0, "partner":"4de7" @@ -942671,10 +946809,6 @@ "sim":50.0, "partner":"7o9p" }, - { - "sim":50.0, - "partner":"8tne" - }, { "sim":50.0, "partner":"6clw" @@ -942687,6 +946821,10 @@ "sim":50.0, "partner":"3obw" }, + { + "sim":50.0, + "partner":"8tne" + }, { "sim":50.0, "partner":"3wcg" @@ -942759,10 +946897,6 @@ "sim":50.0, "partner":"4ot7" }, - { - "sim":50.0, - "partner":"6put" - }, { "sim":50.0, "partner":"6puw" @@ -942777,15 +946911,15 @@ }, { "sim":50.0, - "partner":"5u1c" + "partner":"6puz" }, { "sim":50.0, - "partner":"6puz" + "partner":"5u1c" }, { "sim":50.0, - "partner":"7azd" + "partner":"6put" }, { "sim":50.0, @@ -942817,16 +946951,20 @@ }, { "sim":50.0, - "partner":"5x06" + "partner":"7azg" }, { "sim":50.0, - "partner":"7azg" + "partner":"5x06" }, { "sim":50.0, "partner":"7azc" }, + { + "sim":50.0, + "partner":"7azd" + }, { "sim":50.0, "partner":"6d5a" @@ -942879,10 +947017,6 @@ "sim":50.0, "partner":"3egt" }, - { - "sim":50.0, - "partner":"8hsv" - }, { "sim":50.0, "partner":"4ov4" @@ -942897,11 +947031,11 @@ }, { "sim":50.0, - "partner":"4bko" + "partner":"8hsv" }, { "sim":50.0, - "partner":"5cu7" + "partner":"4bko" }, { "sim":50.0, @@ -942915,6 +947049,10 @@ "sim":50.0, "partner":"5cx4" }, + { + "sim":50.0, + "partner":"5cu7" + }, { "sim":50.0, "partner":"6hr7" @@ -942929,15 +947067,15 @@ }, { "sim":50.0, - "partner":"7d88" + "partner":"8w72" }, { "sim":50.0, - "partner":"7d89" + "partner":"7d88" }, { "sim":50.0, - "partner":"8w72" + "partner":"7d89" }, { "sim":50.0, @@ -942945,11 +947083,11 @@ }, { "sim":50.0, - "partner":"7r39" + "partner":"3c48" }, { "sim":50.0, - "partner":"3c48" + "partner":"7r39" }, { "sim":50.0, @@ -943011,10 +947149,6 @@ "sim":50.0, "partner":"4kk0" }, - { - "sim":50.0, - "partner":"7tfc" - }, { "sim":50.0, "partner":"7d4k" @@ -943027,6 +947161,10 @@ "sim":50.0, "partner":"7d4n" }, + { + "sim":50.0, + "partner":"7tfc" + }, { "sim":50.0, "partner":"4j1q" @@ -943035,6 +947173,18 @@ "sim":50.0, "partner":"4j1s" }, + { + "sim":50.0, + "partner":"8wn5" + }, + { + "sim":50.0, + "partner":"8wn6" + }, + { + "sim":50.0, + "partner":"8wna" + }, { "sim":50.0, "partner":"8tge" @@ -943059,10 +947209,6 @@ "sim":50.0, "partner":"8ufj" }, - { - "sim":50.0, - "partner":"2wc4" - }, { "sim":50.0, "partner":"1oif" @@ -943177,16 +947323,20 @@ }, { "sim":50.0, - "partner":"6j0u" + "partner":"2wc4" }, { "sim":50.0, - "partner":"6ak4" + "partner":"6j0u" }, { "sim":50.0, "partner":"6aej" }, + { + "sim":50.0, + "partner":"6ak4" + }, { "sim":50.0, "partner":"4kc7" @@ -943201,11 +947351,11 @@ }, { "sim":50.0, - "partner":"4dqv" + "partner":"4u5q" }, { "sim":50.0, - "partner":"4u5q" + "partner":"4dqv" }, { "sim":50.0, @@ -943247,10 +947397,6 @@ "sim":50.0, "partner":"3udt" }, - { - "sim":50.0, - "partner":"4ie7" - }, { "sim":50.0, "partner":"4cxw" @@ -943269,15 +947415,15 @@ }, { "sim":50.0, - "partner":"4idz" + "partner":"7e8z" }, { "sim":50.0, - "partner":"4ie0" + "partner":"4idz" }, { "sim":50.0, - "partner":"7e8z" + "partner":"4ie0" }, { "sim":50.0, @@ -943295,6 +947441,10 @@ "sim":50.0, "partner":"4qho" }, + { + "sim":50.0, + "partner":"4ie7" + }, { "sim":50.0, "partner":"6u4z" @@ -943319,14 +947469,6 @@ "sim":50.0, "partner":"3n6r" }, - { - "sim":50.0, - "partner":"8aq3" - }, - { - "sim":50.0, - "partner":"8aq4" - }, { "sim":50.0, "partner":"7aci" @@ -943335,10 +947477,6 @@ "sim":50.0, "partner":"8b0k" }, - { - "sim":50.0, - "partner":"5n6h" - }, { "sim":50.0, "partner":"8b0l" @@ -943351,6 +947489,10 @@ "sim":50.0, "partner":"8b0n" }, + { + "sim":50.0, + "partner":"5n6h" + }, { "sim":50.0, "partner":"8b0o" @@ -943367,6 +947509,14 @@ "sim":50.0, "partner":"5n6l" }, + { + "sim":50.0, + "partner":"8aq3" + }, + { + "sim":50.0, + "partner":"8aq4" + }, { "sim":50.0, "partner":"7lha" @@ -943405,7 +947555,7 @@ }, { "sim":50.0, - "partner":"5m12" + "partner":"6gwg" }, { "sim":50.0, @@ -943413,31 +947563,31 @@ }, { "sim":50.0, - "partner":"6gwf" + "partner":"6gta" }, { "sim":50.0, - "partner":"6gwg" + "partner":"5m16" }, { "sim":50.0, - "partner":"5m16" + "partner":"6gvd" }, { "sim":50.0, - "partner":"6gta" + "partner":"5m0x" }, { "sim":50.0, - "partner":"6gvd" + "partner":"6gx8" }, { "sim":50.0, - "partner":"5m0x" + "partner":"5m12" }, { "sim":50.0, - "partner":"6gx8" + "partner":"6gwf" }, { "sim":50.0, @@ -943469,15 +947619,15 @@ }, { "sim":50.0, - "partner":"7w1c" + "partner":"7w1d" }, { "sim":50.0, - "partner":"7w1d" + "partner":"7w1e" }, { "sim":50.0, - "partner":"7w1e" + "partner":"7w1c" }, { "sim":50.0, @@ -943489,16 +947639,12 @@ }, { "sim":50.0, - "partner":"5uw0" + "partner":"5uw1" }, { "sim":50.0, "partner":"5vnc" }, - { - "sim":50.0, - "partner":"5uw1" - }, { "sim":50.0, "partner":"5uw4" @@ -943509,7 +947655,7 @@ }, { "sim":50.0, - "partner":"3rsz" + "partner":"5uw0" }, { "sim":50.0, @@ -943539,6 +947685,10 @@ "sim":50.0, "partner":"3nch" }, + { + "sim":50.0, + "partner":"3rsz" + }, { "sim":50.0, "partner":"8eax" @@ -943559,10 +947709,6 @@ "sim":50.0, "partner":"2wco" }, - { - "sim":50.0, - "partner":"6edw" - }, { "sim":50.0, "partner":"6edz" @@ -943573,19 +947719,11 @@ }, { "sim":50.0, - "partner":"8bou" - }, - { - "sim":50.0, - "partner":"3ahc" - }, - { - "sim":50.0, - "partner":"3ahd" + "partner":"6edw" }, { "sim":50.0, - "partner":"3ahe" + "partner":"8bou" }, { "sim":50.0, @@ -943609,11 +947747,15 @@ }, { "sim":50.0, - "partner":"4j3t" + "partner":"3ahc" }, { "sim":50.0, - "partner":"4j3u" + "partner":"3ahd" + }, + { + "sim":50.0, + "partner":"3ahe" }, { "sim":50.0, @@ -943631,6 +947773,14 @@ "sim":50.0, "partner":"4j3s" }, + { + "sim":50.0, + "partner":"4j3t" + }, + { + "sim":50.0, + "partner":"4j3u" + }, { "sim":50.0, "partner":"7s6b" @@ -943645,15 +947795,15 @@ }, { "sim":50.0, - "partner":"7o3m" + "partner":"7o3n" }, { "sim":50.0, - "partner":"7o3n" + "partner":"7o3l" }, { "sim":50.0, - "partner":"7o3l" + "partner":"7o3m" }, { "sim":50.0, @@ -943687,10 +947837,6 @@ } ], "struct_thr_sim_natural":[ - { - "sim":0.9534999728, - "partner":"7v03" - }, { "sim":0.9603999853, "partner":"1sw3" @@ -943704,20 +947850,24 @@ "partner":"1tpv" }, { - "sim":0.9539999962, - "partner":"1tpu" + "sim":0.9534999728, + "partner":"7v03" + }, + { + "sim":0.9520999789, + "partner":"1tpw" }, { "sim":0.9556000233, "partner":"1tpb" }, { - "sim":0.9575999975, - "partner":"1tpc" + "sim":0.9539999962, + "partner":"1tpu" }, { - "sim":0.9520999789, - "partner":"1tpw" + "sim":0.9575999975, + "partner":"1tpc" } ], "seq_max_sim_designed":{ @@ -943788,123 +947938,123 @@ ], "subtitle":"Crystal structure of the reconstruction of the ancestral triosephosphate isomerase of the last opisthokont common ancestor obtained by maximum likelihood with pgh", "tags":[ - "triose phosphate isomerase", + "isomerase", "ancestral sequence reconstruction", - "isomerase" + "triose phosphate isomerase" ], "keywords":[ - "work", - "tims", - "analysis", - "evolution", - "unfolding", - "lineages", - "evidence", - "oligomers", - "monomeric", - "located", - "part", - "bonds", - "conserved", - "test", - "isomerase", - "physicochemical", "opisthokonts", - "protozoan", - "reconstruction", - "sequences", - "robustness", - "equilibrium", - "structure", - "monomer", - "applied", - "oligomer", - "resembles", - "unstable", - "spectroscopic", + "tot", + "hydrodynamic", + "well", + "opisthokonta", + "presence", + "differences", + "bottom", + "locatims", "locatim", - "structured", - "reversible", - "resembling", - "reached", - "similar", - "infer", - "obligated", - "calorimetric", + "unstable", + "parameters", + "resembles", + "physicochemical", + "study", "indicated", - "although", - "strongly", - "locatims", - "presence", - "used", - "ancestral", - "comparative", - "structures", - "transitions", - "function", + "unfolding", "showed", - "triosephosphate", - "intermediates", + "equilibrium", "extensive", + "test", + "catalytic", + "two", + "infer", + "lineages", + "similar", + "worst", + "reconstructed", "shows", - "coupled", + "conformational", + "isomerase", + "ones", + "intermediates", + "although", + "last", + "case", + "strongly", + "triosephosphate", + "stability", + "part", + "evidence", + "characterization", + "several", + "ancestral", "hydrogen", "inference", - "properties", - "previously", - "stability", - "monomers", - "bottom", + "found", + "reached", + "\u03b4g", + "resembling", + "evolution", "higher", - "common", - "worst", - "methodologies", - "catalytic", - "temperature", - "four", - "unf", "diverged", - "observed", - "several", - "melting", - "characterization", - "confidence", - "rather", - "\u03b4g", - "high", - "sequence", - "parameters", + "robustness", + "four", + "monomer", + "barrel", + "correlation", "increase", + "spectroscopic", + "calorimetric", + "work", + "used", "extant", - "notably", - "ancestor", - "ones", - "tim", - "hydrodynamic", + "different", + "transitions", + "monomers", + "properties", + "bonds", + "also", + "reversible", + "confidence", + "inactive", + "methodologies", + "oligomer", + "unf", "plausible", + "notably", + "sequence", + "applied", + "common", "3d", - "opisthokonta", - "conformational", - "estimated", - "also", - "study", + "analysis", + "coupled", + "sequences", + "comparative", + "conserved", + "rather", + "observed", + "structures", + "reconstruction", + "oligomers", + "previously", + "structured", + "structure", + "monomeric", "fungi", - "barrel", - "tot", - "well", - "last", - "different", - "found", - "two", - "reconstructed", - "inactive", + "scenario", + "temperature", + "biophysical", + "function", + "melting", + "obligated", "energetics", + "located", + "high", + "estimated", + "tim", + "tims", + "ancestor", "animals", - "differences", - "scenario", - "case", - "correlation", - "biophysical" + "protozoan" ], "release_date":"2024-09-04", "publication":"\"Stable monomers in the ancestral sequence reconstruction of the last opisthokont common ancestor of dimeric triosephosphate isomerase\", Protein Sci., 33, e5134-e5134", @@ -943941,19 +948091,19 @@ }, { "sim":520.0, - "partner":"8v0a" + "partner":"8w08" }, { "sim":520.0, - "partner":"8w08" + "partner":"8v0a" }, { "sim":496.0, - "partner":"8v2w" + "partner":"8v09" }, { "sim":496.0, - "partner":"8v09" + "partner":"8v2w" }, { "sim":485.0, @@ -943973,11 +948123,11 @@ }, { "sim":51.0, - "partner":"8c66" + "partner":"8adx" }, { "sim":51.0, - "partner":"8adx" + "partner":"8c66" }, { "sim":50.0, @@ -944079,11 +948229,11 @@ }, { "sim":341.0, - "partner":"8tim" + "partner":"1tph" }, { "sim":341.0, - "partner":"1tph" + "partner":"8tim" }, { "sim":341.0, @@ -944135,23 +948285,23 @@ }, { "sim":339.0, - "partner":"1r2s" + "partner":"4owg" }, { "sim":339.0, - "partner":"1r2t" + "partner":"1r2r" }, { "sim":339.0, - "partner":"4owg" + "partner":"1hti" }, { "sim":339.0, - "partner":"1hti" + "partner":"1r2s" }, { "sim":339.0, - "partner":"1r2r" + "partner":"1r2t" }, { "sim":339.0, @@ -944271,27 +948421,27 @@ }, { "sim":313.0, - "partner":"8j7c" + "partner":"4gnj" }, { "sim":313.0, - "partner":"8jbp" + "partner":"8j7c" }, { "sim":313.0, - "partner":"4gnj" + "partner":"8jbp" }, { "sim":307.0, - "partner":"2ypi" + "partner":"1ypi" }, { "sim":307.0, - "partner":"1ypi" + "partner":"7tim" }, { "sim":307.0, - "partner":"7tim" + "partner":"2ypi" }, { "sim":305.0, @@ -944307,11 +948457,11 @@ }, { "sim":299.0, - "partner":"1nf0" + "partner":"1ney" }, { "sim":299.0, - "partner":"1ney" + "partner":"1nf0" }, { "sim":295.0, @@ -944339,11 +948489,11 @@ }, { "sim":290.0, - "partner":"4o50" + "partner":"4o57" }, { "sim":290.0, - "partner":"4o57" + "partner":"4o50" }, { "sim":290.0, @@ -944371,51 +948521,51 @@ }, { "sim":277.0, - "partner":"7az3" + "partner":"1n55" }, { "sim":277.0, - "partner":"2vxn" + "partner":"7az9" }, { "sim":277.0, - "partner":"7az4" + "partner":"7aza" }, { "sim":277.0, - "partner":"1n55" + "partner":"2y61" }, { "sim":277.0, - "partner":"7az9" + "partner":"2y62" }, { "sim":277.0, - "partner":"7aza" + "partner":"2y63" }, { "sim":277.0, - "partner":"2y61" + "partner":"7abx" }, { "sim":277.0, - "partner":"2y62" + "partner":"7az3" }, { "sim":277.0, - "partner":"2y63" + "partner":"1qds" }, { "sim":277.0, - "partner":"1if2" + "partner":"7az4" }, { "sim":277.0, - "partner":"7abx" + "partner":"1if2" }, { "sim":277.0, - "partner":"1qds" + "partner":"2vxn" }, { "sim":276.0, @@ -944449,10 +948599,6 @@ "sim":271.0, "partner":"1iig" }, - { - "sim":271.0, - "partner":"2v0t" - }, { "sim":271.0, "partner":"1iih" @@ -944463,11 +948609,11 @@ }, { "sim":271.0, - "partner":"1ag1" + "partner":"2oma" }, { "sim":271.0, - "partner":"2oma" + "partner":"1ag1" }, { "sim":271.0, @@ -944487,15 +948633,19 @@ }, { "sim":271.0, - "partner":"4tim" + "partner":"2v0t" }, { "sim":271.0, - "partner":"2v5l" + "partner":"6tim" }, { "sim":271.0, - "partner":"6tim" + "partner":"4tim" + }, + { + "sim":271.0, + "partner":"2v5l" }, { "sim":271.0, @@ -944551,7 +948701,7 @@ }, { "sim":268.0, - "partner":"1kv5" + "partner":"5i3f" }, { "sim":268.0, @@ -944559,7 +948709,7 @@ }, { "sim":268.0, - "partner":"5i3f" + "partner":"1kv5" }, { "sim":268.0, @@ -944587,19 +948737,15 @@ }, { "sim":261.0, - "partner":"2vfd" + "partner":"4ywi" }, { "sim":261.0, - "partner":"2vfe" + "partner":"2vfd" }, { "sim":261.0, - "partner":"4ywi" - }, - { - "sim":260.0, - "partner":"1lzo" + "partner":"2vfe" }, { "sim":260.0, @@ -944625,6 +948771,10 @@ "sim":260.0, "partner":"1m7o" }, + { + "sim":260.0, + "partner":"1lzo" + }, { "sim":260.0, "partner":"1m7p" @@ -944651,31 +948801,31 @@ }, { "sim":258.0, - "partner":"5gv4" + "partner":"2vff" }, { "sim":258.0, - "partner":"5gzp" + "partner":"5bmw" }, { "sim":258.0, - "partner":"2vff" + "partner":"2vfg" }, { "sim":258.0, - "partner":"5bmw" + "partner":"4zz9" }, { "sim":258.0, - "partner":"2vfg" + "partner":"5bnk" }, { "sim":258.0, - "partner":"4zz9" + "partner":"5gzp" }, { "sim":258.0, - "partner":"5bnk" + "partner":"5gv4" }, { "sim":257.0, @@ -944817,10 +948967,6 @@ "sim":228.0, "partner":"4pcf" }, - { - "sim":228.0, - "partner":"3uwz" - }, { "sim":228.0, "partner":"3uwu" @@ -944837,6 +948983,10 @@ "sim":228.0, "partner":"3uwy" }, + { + "sim":228.0, + "partner":"3uwz" + }, { "sim":226.0, "partner":"4y96" @@ -945095,43 +949245,39 @@ }, { "sim":55.0, - "partner":"5y0f" - }, - { - "sim":55.0, - "partner":"5y0g" + "partner":"4nns" }, { "sim":55.0, - "partner":"4nns" + "partner":"4nnt" }, { "sim":55.0, - "partner":"4nnt" + "partner":"6ljs" }, { "sim":55.0, - "partner":"5y12" + "partner":"6ljt" }, { "sim":55.0, - "partner":"6ljs" + "partner":"8wdx" }, { "sim":55.0, - "partner":"5d45" + "partner":"5y12" }, { "sim":55.0, - "partner":"5y13" + "partner":"6lju" }, { "sim":55.0, - "partner":"6ljt" + "partner":"5d45" }, { "sim":55.0, - "partner":"6lju" + "partner":"5y13" }, { "sim":55.0, @@ -945155,7 +949301,7 @@ }, { "sim":55.0, - "partner":"8wdx" + "partner":"8we3" }, { "sim":55.0, @@ -945167,11 +949313,15 @@ }, { "sim":55.0, - "partner":"8we3" + "partner":"5y0x" }, { "sim":55.0, - "partner":"5y0x" + "partner":"5y0f" + }, + { + "sim":55.0, + "partner":"5y0g" }, { "sim":55.0, @@ -945285,10 +949435,6 @@ "sim":54.0, "partner":"1nyn" }, - { - "sim":54.0, - "partner":"5zrk" - }, { "sim":54.0, "partner":"5zrl" @@ -945317,6 +949463,10 @@ "sim":54.0, "partner":"5zri" }, + { + "sim":54.0, + "partner":"5zrk" + }, { "sim":54.0, "partner":"3rsw" @@ -945351,11 +949501,11 @@ }, { "sim":54.0, - "partner":"3th5" + "partner":"4gzl" }, { "sim":54.0, - "partner":"4gzl" + "partner":"3th5" }, { "sim":54.0, @@ -945391,19 +949541,19 @@ }, { "sim":54.0, - "partner":"8vip" + "partner":"8vit" }, { "sim":54.0, - "partner":"8viq" + "partner":"8vip" }, { "sim":54.0, - "partner":"8vir" + "partner":"8viq" }, { "sim":54.0, - "partner":"8vit" + "partner":"8vir" }, { "sim":54.0, @@ -945473,10 +949623,6 @@ "sim":54.0, "partner":"5xix" }, - { - "sim":54.0, - "partner":"2cj9" - }, { "sim":54.0, "partner":"2cja" @@ -945489,6 +949635,10 @@ "sim":54.0, "partner":"2cjb" }, + { + "sim":54.0, + "partner":"2cj9" + }, { "sim":53.0, "partner":"2jve" @@ -945595,15 +949745,15 @@ }, { "sim":53.0, - "partner":"6j0l" + "partner":"6j0g" }, { "sim":53.0, - "partner":"6j0g" + "partner":"6j0k" }, { "sim":53.0, - "partner":"6j0k" + "partner":"6j0l" }, { "sim":53.0, @@ -945627,23 +949777,23 @@ }, { "sim":53.0, - "partner":"6ihr" + "partner":"6ihv" }, { "sim":53.0, - "partner":"6iht" + "partner":"6ihw" }, { "sim":53.0, - "partner":"6ihu" + "partner":"6ihr" }, { "sim":53.0, - "partner":"6ihv" + "partner":"6iht" }, { "sim":53.0, - "partner":"6ihw" + "partner":"6ihu" }, { "sim":53.0, @@ -945711,11 +949861,11 @@ }, { "sim":53.0, - "partner":"3la8" + "partner":"3lba" }, { "sim":53.0, - "partner":"3lba" + "partner":"3la8" }, { "sim":53.0, @@ -945733,10 +949883,6 @@ "sim":53.0, "partner":"6jtz" }, - { - "sim":53.0, - "partner":"3pz9" - }, { "sim":53.0, "partner":"3pzg" @@ -945761,6 +949907,10 @@ "sim":53.0, "partner":"3pzq" }, + { + "sim":53.0, + "partner":"3pz9" + }, { "sim":53.0, "partner":"3fvm" @@ -945823,15 +949973,15 @@ }, { "sim":53.0, - "partner":"7mdl" + "partner":"8g9z" }, { "sim":53.0, - "partner":"8g9z" + "partner":"7l1t" }, { "sim":53.0, - "partner":"7l1t" + "partner":"7mdl" }, { "sim":53.0, @@ -945855,11 +950005,11 @@ }, { "sim":53.0, - "partner":"2vbg" + "partner":"2vbf" }, { "sim":53.0, - "partner":"2vbf" + "partner":"2vbg" }, { "sim":53.0, @@ -945943,15 +950093,15 @@ }, { "sim":52.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":52.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":52.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":52.0, @@ -945991,19 +950141,19 @@ }, { "sim":52.0, - "partner":"1x24" + "partner":"4gzd" }, { "sim":52.0, - "partner":"4gzc" + "partner":"1zcl" }, { "sim":52.0, - "partner":"4gzd" + "partner":"1x24" }, { "sim":52.0, - "partner":"1zcl" + "partner":"4gzc" }, { "sim":52.0, @@ -946035,11 +950185,11 @@ }, { "sim":52.0, - "partner":"6kz6" + "partner":"8be9" }, { "sim":52.0, - "partner":"8be9" + "partner":"6kz6" }, { "sim":52.0, @@ -946077,10 +950227,6 @@ "sim":52.0, "partner":"3vwv" }, - { - "sim":52.0, - "partner":"3l1u" - }, { "sim":52.0, "partner":"3l1v" @@ -946097,6 +950243,10 @@ "sim":52.0, "partner":"3esr" }, + { + "sim":52.0, + "partner":"3l1u" + }, { "sim":52.0, "partner":"2kn6" @@ -946131,19 +950281,19 @@ }, { "sim":52.0, - "partner":"4bmx" + "partner":"4bmz" }, { "sim":52.0, - "partner":"4bmy" + "partner":"4bn0" }, { "sim":52.0, - "partner":"4bmz" + "partner":"4bmx" }, { "sim":52.0, - "partner":"4bn0" + "partner":"4bmy" }, { "sim":52.0, @@ -946221,10 +950371,6 @@ "sim":52.0, "partner":"6l86" }, - { - "sim":52.0, - "partner":"5mit" - }, { "sim":52.0, "partner":"5mjk" @@ -946249,6 +950395,10 @@ "sim":52.0, "partner":"5mis" }, + { + "sim":52.0, + "partner":"5mit" + }, { "sim":52.0, "partner":"2yhw" @@ -946275,11 +950425,11 @@ }, { "sim":52.0, - "partner":"7js3" + "partner":"8g5w" }, { "sim":52.0, - "partner":"8g5w" + "partner":"7js3" }, { "sim":52.0, @@ -946317,10 +950467,6 @@ "sim":52.0, "partner":"4rhq" }, - { - "sim":52.0, - "partner":"5g6t" - }, { "sim":52.0, "partner":"5g5u" @@ -946347,7 +950493,7 @@ }, { "sim":52.0, - "partner":"7ajm" + "partner":"5g6t" }, { "sim":52.0, @@ -946367,15 +950513,15 @@ }, { "sim":52.0, - "partner":"5jyf" + "partner":"7ajm" }, { "sim":52.0, - "partner":"8phd" + "partner":"5v8x" }, { "sim":52.0, - "partner":"5v8x" + "partner":"8phv" }, { "sim":52.0, @@ -946385,6 +950531,10 @@ "sim":52.0, "partner":"5utl" }, + { + "sim":52.0, + "partner":"8phd" + }, { "sim":52.0, "partner":"5utm" @@ -946403,27 +950553,7 @@ }, { "sim":52.0, - "partner":"8phv" - }, - { - "sim":52.0, - "partner":"7a53" - }, - { - "sim":52.0, - "partner":"7ajw" - }, - { - "sim":52.0, - "partner":"7akb" - }, - { - "sim":52.0, - "partner":"7ajy" - }, - { - "sim":52.0, - "partner":"7a5l" + "partner":"5jyf" }, { "sim":52.0, @@ -946485,22 +950615,42 @@ "sim":52.0, "partner":"7aka" }, + { + "sim":52.0, + "partner":"7a53" + }, { "sim":52.0, "partner":"7akl" }, { "sim":52.0, - "partner":"8wov" + "partner":"7ajw" }, { "sim":52.0, - "partner":"8wow" + "partner":"7akb" + }, + { + "sim":52.0, + "partner":"7ajy" + }, + { + "sim":52.0, + "partner":"7a5l" }, { "sim":52.0, "partner":"8wop" }, + { + "sim":52.0, + "partner":"8wov" + }, + { + "sim":52.0, + "partner":"8wow" + }, { "sim":52.0, "partner":"4rl1" @@ -946621,10 +950771,6 @@ "sim":51.0, "partner":"1te4" }, - { - "sim":51.0, - "partner":"4hmr" - }, { "sim":51.0, "partner":"4hls" @@ -946637,6 +950783,10 @@ "sim":51.0, "partner":"1yx3" }, + { + "sim":51.0, + "partner":"4hmr" + }, { "sim":51.0, "partner":"6l8p" @@ -946797,10 +950947,6 @@ "sim":51.0, "partner":"6a4c" }, - { - "sim":51.0, - "partner":"6ueo" - }, { "sim":51.0, "partner":"6uep" @@ -946813,6 +950959,10 @@ "sim":51.0, "partner":"6uer" }, + { + "sim":51.0, + "partner":"6ueo" + }, { "sim":51.0, "partner":"3wyd" @@ -946839,16 +950989,12 @@ }, { "sim":51.0, - "partner":"7o2t" + "partner":"6z17" }, { "sim":51.0, "partner":"7o2u" }, - { - "sim":51.0, - "partner":"6z17" - }, { "sim":51.0, "partner":"6yz3" @@ -946865,6 +951011,10 @@ "sim":51.0, "partner":"6z5k" }, + { + "sim":51.0, + "partner":"7o2t" + }, { "sim":51.0, "partner":"1zw9" @@ -946941,14 +951091,6 @@ "sim":51.0, "partner":"6azo" }, - { - "sim":51.0, - "partner":"8wbk" - }, - { - "sim":51.0, - "partner":"8wbl" - }, { "sim":51.0, "partner":"8wbm" @@ -946971,20 +951113,28 @@ }, { "sim":51.0, - "partner":"6ubb" + "partner":"8wbk" }, { "sim":51.0, - "partner":"6ihs" + "partner":"8wbl" }, { "sim":51.0, "partner":"6ub8" }, + { + "sim":51.0, + "partner":"6ubb" + }, { "sim":51.0, "partner":"6uba" }, + { + "sim":51.0, + "partner":"6ihs" + }, { "sim":51.0, "partner":"4ag0" @@ -946999,11 +951149,11 @@ }, { "sim":51.0, - "partner":"5c2d" + "partner":"6dli" }, { "sim":51.0, - "partner":"6dli" + "partner":"5c2d" }, { "sim":51.0, @@ -947025,14 +951175,6 @@ "sim":51.0, "partner":"5vrc" }, - { - "sim":51.0, - "partner":"3quo" - }, - { - "sim":51.0, - "partner":"3qvf" - }, { "sim":51.0, "partner":"3qur" @@ -947061,6 +951203,14 @@ "sim":51.0, "partner":"3qun" }, + { + "sim":51.0, + "partner":"3quo" + }, + { + "sim":51.0, + "partner":"3qvf" + }, { "sim":51.0, "partner":"3jyy" @@ -947109,10 +951259,6 @@ "sim":51.0, "partner":"3v91" }, - { - "sim":51.0, - "partner":"6wye" - }, { "sim":51.0, "partner":"2jfo" @@ -947133,6 +951279,10 @@ "sim":51.0, "partner":"4ats" }, + { + "sim":51.0, + "partner":"6wye" + }, { "sim":51.0, "partner":"7umj" @@ -947151,11 +951301,11 @@ }, { "sim":51.0, - "partner":"6aa8" + "partner":"7eov" }, { "sim":51.0, - "partner":"7eov" + "partner":"6aa8" }, { "sim":51.0, @@ -947165,10 +951315,6 @@ "sim":51.0, "partner":"5dz7" }, - { - "sim":51.0, - "partner":"8wlb" - }, { "sim":51.0, "partner":"8wl5" @@ -947181,6 +951327,10 @@ "sim":51.0, "partner":"8wl9" }, + { + "sim":51.0, + "partner":"8wlb" + }, { "sim":51.0, "partner":"3zgc" @@ -947203,51 +951353,51 @@ }, { "sim":51.0, - "partner":"7q2b" + "partner":"7q2f" }, { "sim":51.0, - "partner":"3ha3" + "partner":"7q2g" }, { "sim":51.0, - "partner":"7q2c" + "partner":"7q2h" }, { "sim":51.0, - "partner":"7q2d" + "partner":"3ha5" }, { "sim":51.0, - "partner":"7q2e" + "partner":"2fk7" }, { "sim":51.0, - "partner":"7q2f" + "partner":"2fk8" }, { "sim":51.0, - "partner":"7q2g" + "partner":"3ha7" }, { "sim":51.0, - "partner":"7q2h" + "partner":"7q2b" }, { "sim":51.0, - "partner":"3ha5" + "partner":"7q2c" }, { "sim":51.0, - "partner":"2fk7" + "partner":"3ha3" }, { "sim":51.0, - "partner":"2fk8" + "partner":"7q2d" }, { "sim":51.0, - "partner":"3ha7" + "partner":"7q2e" }, { "sim":51.0, @@ -947343,31 +951493,31 @@ }, { "sim":51.0, - "partner":"4w7v" + "partner":"7f8d" }, { "sim":51.0, - "partner":"4w7w" + "partner":"7by8" }, { "sim":51.0, - "partner":"7f8d" + "partner":"7by9" }, { "sim":51.0, - "partner":"7by8" + "partner":"7bya" }, { "sim":51.0, - "partner":"7by9" + "partner":"4w7u" }, { "sim":51.0, - "partner":"7bya" + "partner":"4w7v" }, { "sim":51.0, - "partner":"4w7u" + "partner":"4w7w" }, { "sim":51.0, @@ -947421,14 +951571,6 @@ "sim":51.0, "partner":"4hbk" }, - { - "sim":51.0, - "partner":"4fif" - }, - { - "sim":51.0, - "partner":"7s46" - }, { "sim":51.0, "partner":"4fig" @@ -947479,11 +951621,11 @@ }, { "sim":51.0, - "partner":"6sf5" + "partner":"4fif" }, { "sim":51.0, - "partner":"7dw8" + "partner":"7s46" }, { "sim":51.0, @@ -947507,19 +951649,23 @@ }, { "sim":51.0, - "partner":"3ren" + "partner":"6sf5" }, { "sim":51.0, - "partner":"8fbx" + "partner":"7dw8" }, { "sim":51.0, - "partner":"5xm6" + "partner":"3ren" }, { "sim":51.0, - "partner":"2ikf" + "partner":"8fbx" + }, + { + "sim":51.0, + "partner":"5xm6" }, { "sim":51.0, @@ -947573,6 +951719,10 @@ "sim":51.0, "partner":"5kal" }, + { + "sim":51.0, + "partner":"2ikf" + }, { "sim":51.0, "partner":"6nxc" @@ -947593,10 +951743,6 @@ "sim":51.0, "partner":"2him" }, - { - "sim":51.0, - "partner":"1vsu" - }, { "sim":51.0, "partner":"1vsv" @@ -947653,6 +951799,10 @@ "sim":51.0, "partner":"3m5c" }, + { + "sim":51.0, + "partner":"1vsu" + }, { "sim":51.0, "partner":"3m5d" @@ -947673,10 +951823,6 @@ "sim":51.0, "partner":"7us5" }, - { - "sim":51.0, - "partner":"4m1i" - }, { "sim":51.0, "partner":"4d8f" @@ -947691,47 +951837,51 @@ }, { "sim":51.0, - "partner":"7wxl" + "partner":"4m1i" }, { "sim":51.0, - "partner":"7wxm" + "partner":"7wxp" }, { "sim":51.0, - "partner":"7wxn" + "partner":"7wxq" }, { "sim":51.0, - "partner":"7wxo" + "partner":"7wxr" }, { "sim":51.0, - "partner":"7wxp" + "partner":"7xte" }, { "sim":51.0, - "partner":"7wxq" + "partner":"7xtf" }, { "sim":51.0, - "partner":"7wxr" + "partner":"7wxj" }, { "sim":51.0, - "partner":"7xte" + "partner":"7wxk" }, { "sim":51.0, - "partner":"7xtf" + "partner":"7wxl" }, { "sim":51.0, - "partner":"7wxj" + "partner":"7wxm" }, { "sim":51.0, - "partner":"7wxk" + "partner":"7wxn" + }, + { + "sim":51.0, + "partner":"7wxo" }, { "sim":51.0, @@ -947769,17 +951919,13 @@ "sim":51.0, "partner":"3wnd" }, - { - "sim":51.0, - "partner":"5f5m" - }, { "sim":51.0, "partner":"5f5o" }, { "sim":51.0, - "partner":"3c1y" + "partner":"5f5m" }, { "sim":51.0, @@ -947807,7 +951953,7 @@ }, { "sim":51.0, - "partner":"4zhs" + "partner":"3c1y" }, { "sim":51.0, @@ -947835,19 +951981,19 @@ }, { "sim":51.0, - "partner":"4ltz" + "partner":"4zhs" }, { "sim":51.0, - "partner":"7kj8" + "partner":"3kbk" }, { "sim":51.0, - "partner":"7kj9" + "partner":"6ax9" }, { "sim":51.0, - "partner":"3kbk" + "partner":"7kjd" }, { "sim":51.0, @@ -947855,7 +952001,7 @@ }, { "sim":51.0, - "partner":"6ax9" + "partner":"7kje" }, { "sim":51.0, @@ -947863,39 +952009,31 @@ }, { "sim":51.0, - "partner":"8su2" - }, - { - "sim":51.0, - "partner":"8su3" - }, - { - "sim":51.0, - "partner":"7kjd" + "partner":"6axu" }, { "sim":51.0, - "partner":"8su4" + "partner":"7kjf" }, { "sim":51.0, - "partner":"6axu" + "partner":"8su2" }, { "sim":51.0, - "partner":"7kje" + "partner":"7kjg" }, { "sim":51.0, - "partner":"8su5" + "partner":"8su3" }, { "sim":51.0, - "partner":"7kjf" + "partner":"8v3k" }, { "sim":51.0, - "partner":"7kjg" + "partner":"8su4" }, { "sim":51.0, @@ -947903,11 +952041,11 @@ }, { "sim":51.0, - "partner":"3kb9" + "partner":"8su5" }, { "sim":51.0, - "partner":"8v3k" + "partner":"3kb9" }, { "sim":51.0, @@ -947945,6 +952083,18 @@ "sim":51.0, "partner":"4luu" }, + { + "sim":51.0, + "partner":"7kj8" + }, + { + "sim":51.0, + "partner":"4ltz" + }, + { + "sim":51.0, + "partner":"7kj9" + }, { "sim":51.0, "partner":"8sm8" @@ -947955,11 +952105,11 @@ }, { "sim":51.0, - "partner":"4wwv" + "partner":"3bu7" }, { "sim":51.0, - "partner":"3bu7" + "partner":"4wwv" }, { "sim":51.0, @@ -948001,10 +952151,6 @@ "sim":51.0, "partner":"4w61" }, - { - "sim":51.0, - "partner":"2gqn" - }, { "sim":51.0, "partner":"2fq6" @@ -948019,15 +952165,15 @@ }, { "sim":51.0, - "partner":"7bvt" + "partner":"2gqn" }, { "sim":51.0, - "partner":"5xpj" + "partner":"7bvt" }, { "sim":51.0, - "partner":"4euh" + "partner":"5xpj" }, { "sim":51.0, @@ -948039,7 +952185,7 @@ }, { "sim":51.0, - "partner":"5dvi" + "partner":"4euh" }, { "sim":51.0, @@ -948049,6 +952195,10 @@ "sim":51.0, "partner":"5dvf" }, + { + "sim":51.0, + "partner":"5dvi" + }, { "sim":51.0, "partner":"5hxk" @@ -948085,10 +952235,6 @@ "sim":51.0, "partner":"7ui4" }, - { - "sim":51.0, - "partner":"4q6q" - }, { "sim":51.0, "partner":"4q6m" @@ -948107,24 +952253,28 @@ }, { "sim":51.0, - "partner":"6v99" + "partner":"4q6q" }, { "sim":51.0, - "partner":"6v9a" + "partner":"6v96" }, { "sim":51.0, - "partner":"6v96" + "partner":"6v99" }, { "sim":51.0, - "partner":"7lr2" + "partner":"6v9a" }, { "sim":51.0, "partner":"7lr1" }, + { + "sim":51.0, + "partner":"7lr2" + }, { "sim":51.0, "partner":"5ctt" @@ -948155,28 +952305,16 @@ }, { "sim":51.0, - "partner":"6mlh" - }, - { - "sim":51.0, - "partner":"6oi8" + "partner":"6nn1" }, { "sim":51.0, - "partner":"6mlw" + "partner":"6n1e" }, { "sim":51.0, "partner":"4mv1" }, - { - "sim":51.0, - "partner":"6nn1" - }, - { - "sim":51.0, - "partner":"6n1e" - }, { "sim":51.0, "partner":"4mv3" @@ -948239,11 +952377,15 @@ }, { "sim":51.0, - "partner":"2gps" + "partner":"6mlh" }, { "sim":51.0, - "partner":"6oi9" + "partner":"6oi8" + }, + { + "sim":51.0, + "partner":"6mlw" }, { "sim":51.0, @@ -948263,20 +952405,28 @@ }, { "sim":51.0, - "partner":"6wiu" + "partner":"2gps" }, { "sim":51.0, - "partner":"8u41" + "partner":"6oi9" }, { "sim":51.0, - "partner":"8u42" + "partner":"6wiu" }, { "sim":51.0, "partner":"2fwr" }, + { + "sim":51.0, + "partner":"8u41" + }, + { + "sim":51.0, + "partner":"8u42" + }, { "sim":51.0, "partner":"8ux5" @@ -948291,15 +952441,15 @@ }, { "sim":51.0, - "partner":"6x0h" + "partner":"6x0j" }, { "sim":51.0, - "partner":"6x0j" + "partner":"6x0k" }, { "sim":51.0, - "partner":"6x0k" + "partner":"6x0h" }, { "sim":51.0, @@ -948323,15 +952473,15 @@ }, { "sim":51.0, - "partner":"4dqw" + "partner":"6gjv" }, { "sim":51.0, - "partner":"6gjv" + "partner":"6gk9" }, { "sim":51.0, - "partner":"6gk9" + "partner":"4dqw" }, { "sim":51.0, @@ -948465,10 +952615,6 @@ "sim":51.0, "partner":"4lh3" }, - { - "sim":51.0, - "partner":"5wm2" - }, { "sim":51.0, "partner":"5wm3" @@ -948489,6 +952635,10 @@ "sim":51.0, "partner":"5wm7" }, + { + "sim":51.0, + "partner":"5wm2" + }, { "sim":51.0, "partner":"3bdl" @@ -948513,10 +952663,6 @@ "sim":51.0, "partner":"5wdg" }, - { - "sim":51.0, - "partner":"6j1e" - }, { "sim":51.0, "partner":"6j1i" @@ -948529,6 +952675,10 @@ "sim":51.0, "partner":"6j0p" }, + { + "sim":51.0, + "partner":"6j1e" + }, { "sim":51.0, "partner":"6k0w" @@ -948543,11 +952693,11 @@ }, { "sim":51.0, - "partner":"3i39" + "partner":"7err" }, { "sim":51.0, - "partner":"7err" + "partner":"3i39" }, { "sim":51.0, @@ -948595,43 +952745,43 @@ }, { "sim":51.0, - "partner":"2yii" + "partner":"4c5u" }, { "sim":51.0, - "partner":"4c5s" + "partner":"4cq5" }, { "sim":51.0, - "partner":"4v2r" + "partner":"4baa" }, { "sim":51.0, - "partner":"4c5u" + "partner":"4c6g" }, { "sim":51.0, - "partner":"4cq5" + "partner":"4bab" }, { "sim":51.0, - "partner":"4baa" + "partner":"4c5r" }, { "sim":51.0, - "partner":"4c6g" + "partner":"2yii" }, { "sim":51.0, - "partner":"4bab" + "partner":"4v2q" }, { "sim":51.0, - "partner":"4c5r" + "partner":"4c5s" }, { "sim":51.0, - "partner":"4v2q" + "partner":"4v2r" }, { "sim":51.0, @@ -948679,11 +952829,11 @@ }, { "sim":51.0, - "partner":"3l7r" + "partner":"3t0c" }, { "sim":51.0, - "partner":"3t0c" + "partner":"3l7r" }, { "sim":51.0, @@ -948701,10 +952851,6 @@ "sim":51.0, "partner":"5n6u" }, - { - "sim":51.0, - "partner":"5y1h" - }, { "sim":51.0, "partner":"5y1k" @@ -948749,6 +952895,10 @@ "sim":51.0, "partner":"5y3i" }, + { + "sim":51.0, + "partner":"5y1h" + }, { "sim":51.0, "partner":"7ufr" @@ -948905,10 +953055,6 @@ "sim":50.0, "partner":"6rcx" }, - { - "sim":50.0, - "partner":"4a41" - }, { "sim":50.0, "partner":"4a44" @@ -948923,11 +953069,11 @@ }, { "sim":50.0, - "partner":"6t73" + "partner":"4a41" }, { "sim":50.0, - "partner":"2vbq" + "partner":"6t73" }, { "sim":50.0, @@ -948941,6 +953087,10 @@ "sim":50.0, "partner":"1s60" }, + { + "sim":50.0, + "partner":"2vbq" + }, { "sim":50.0, "partner":"6o20" @@ -949047,11 +953197,11 @@ }, { "sim":50.0, - "partner":"3s2s" + "partner":"3hth" }, { "sim":50.0, - "partner":"3hth" + "partner":"3s2s" }, { "sim":50.0, @@ -949067,11 +953217,11 @@ }, { "sim":50.0, - "partner":"3oci" + "partner":"3oc3" }, { "sim":50.0, - "partner":"3oc3" + "partner":"3oci" }, { "sim":50.0, @@ -949191,19 +953341,19 @@ }, { "sim":50.0, - "partner":"5tgs" + "partner":"5th5" }, { "sim":50.0, - "partner":"5th5" + "partner":"5tgs" }, { "sim":50.0, - "partner":"6t2r" + "partner":"4nec" }, { "sim":50.0, - "partner":"4nec" + "partner":"6t2r" }, { "sim":50.0, @@ -949235,11 +953385,11 @@ }, { "sim":50.0, - "partner":"6hxo" + "partner":"6hxn" }, { "sim":50.0, - "partner":"6hxn" + "partner":"6hxo" }, { "sim":50.0, @@ -949259,23 +953409,23 @@ }, { "sim":50.0, - "partner":"6fcn" + "partner":"6ypa" }, { "sim":50.0, - "partner":"2wk1" + "partner":"6akv" }, { "sim":50.0, - "partner":"6ypa" + "partner":"6fcm" }, { "sim":50.0, - "partner":"6akv" + "partner":"6fcn" }, { "sim":50.0, - "partner":"6fcm" + "partner":"2wk1" }, { "sim":50.0, @@ -949283,11 +953433,11 @@ }, { "sim":50.0, - "partner":"4rni" + "partner":"4rnj" }, { "sim":50.0, - "partner":"4rnj" + "partner":"4rni" }, { "sim":50.0, @@ -949317,10 +953467,6 @@ "sim":50.0, "partner":"4x9x" }, - { - "sim":50.0, - "partner":"3s3h" - }, { "sim":50.0, "partner":"4gxn" @@ -949347,7 +953493,7 @@ }, { "sim":50.0, - "partner":"7xif" + "partner":"3s3h" }, { "sim":50.0, @@ -949361,6 +953507,10 @@ "sim":50.0, "partner":"7xii" }, + { + "sim":50.0, + "partner":"7xif" + }, { "sim":50.0, "partner":"3doj" @@ -949387,19 +953537,19 @@ }, { "sim":50.0, - "partner":"5zmy" + "partner":"6f1w" }, { "sim":50.0, - "partner":"6f1w" + "partner":"5zmy" }, { "sim":50.0, - "partner":"5okt" + "partner":"7nzy" }, { "sim":50.0, - "partner":"7nzy" + "partner":"5okt" }, { "sim":50.0, @@ -949507,19 +953657,19 @@ }, { "sim":50.0, - "partner":"2pzm" + "partner":"2pzk" }, { "sim":50.0, - "partner":"2pzk" + "partner":"2pzl" }, { "sim":50.0, - "partner":"2pzl" + "partner":"2pzm" }, { "sim":50.0, - "partner":"6lcn" + "partner":"7bsx" }, { "sim":50.0, @@ -949527,11 +953677,11 @@ }, { "sim":50.0, - "partner":"7bsx" + "partner":"3h7r" }, { "sim":50.0, - "partner":"3h7r" + "partner":"6lcn" }, { "sim":50.0, @@ -949577,14 +953727,6 @@ "sim":50.0, "partner":"4hg5" }, - { - "sim":50.0, - "partner":"5tyq" - }, - { - "sim":50.0, - "partner":"5u19" - }, { "sim":50.0, "partner":"5u0n" @@ -949613,6 +953755,14 @@ "sim":50.0, "partner":"5u1i" }, + { + "sim":50.0, + "partner":"5tyq" + }, + { + "sim":50.0, + "partner":"5u19" + }, { "sim":50.0, "partner":"4de7" @@ -949657,10 +953807,6 @@ "sim":50.0, "partner":"7o9p" }, - { - "sim":50.0, - "partner":"8tne" - }, { "sim":50.0, "partner":"6clw" @@ -949673,6 +953819,10 @@ "sim":50.0, "partner":"3obw" }, + { + "sim":50.0, + "partner":"8tne" + }, { "sim":50.0, "partner":"3wcg" @@ -949745,10 +953895,6 @@ "sim":50.0, "partner":"4ot7" }, - { - "sim":50.0, - "partner":"6put" - }, { "sim":50.0, "partner":"6puw" @@ -949763,15 +953909,15 @@ }, { "sim":50.0, - "partner":"5u1c" + "partner":"6puz" }, { "sim":50.0, - "partner":"6puz" + "partner":"5u1c" }, { "sim":50.0, - "partner":"7azd" + "partner":"6put" }, { "sim":50.0, @@ -949803,16 +953949,20 @@ }, { "sim":50.0, - "partner":"5x06" + "partner":"7azg" }, { "sim":50.0, - "partner":"7azg" + "partner":"5x06" }, { "sim":50.0, "partner":"7azc" }, + { + "sim":50.0, + "partner":"7azd" + }, { "sim":50.0, "partner":"6d5a" @@ -949865,10 +954015,6 @@ "sim":50.0, "partner":"3egt" }, - { - "sim":50.0, - "partner":"8hsv" - }, { "sim":50.0, "partner":"4ov4" @@ -949883,11 +954029,11 @@ }, { "sim":50.0, - "partner":"4bko" + "partner":"8hsv" }, { "sim":50.0, - "partner":"5cu7" + "partner":"4bko" }, { "sim":50.0, @@ -949901,6 +954047,10 @@ "sim":50.0, "partner":"5cx4" }, + { + "sim":50.0, + "partner":"5cu7" + }, { "sim":50.0, "partner":"6hr7" @@ -949915,15 +954065,15 @@ }, { "sim":50.0, - "partner":"7d88" + "partner":"8w72" }, { "sim":50.0, - "partner":"7d89" + "partner":"7d88" }, { "sim":50.0, - "partner":"8w72" + "partner":"7d89" }, { "sim":50.0, @@ -949931,11 +954081,11 @@ }, { "sim":50.0, - "partner":"7r39" + "partner":"3c48" }, { "sim":50.0, - "partner":"3c48" + "partner":"7r39" }, { "sim":50.0, @@ -949997,10 +954147,6 @@ "sim":50.0, "partner":"4kk0" }, - { - "sim":50.0, - "partner":"7tfc" - }, { "sim":50.0, "partner":"7d4k" @@ -950013,6 +954159,10 @@ "sim":50.0, "partner":"7d4n" }, + { + "sim":50.0, + "partner":"7tfc" + }, { "sim":50.0, "partner":"4j1q" @@ -950021,6 +954171,18 @@ "sim":50.0, "partner":"4j1s" }, + { + "sim":50.0, + "partner":"8wn5" + }, + { + "sim":50.0, + "partner":"8wn6" + }, + { + "sim":50.0, + "partner":"8wna" + }, { "sim":50.0, "partner":"8tge" @@ -950045,10 +954207,6 @@ "sim":50.0, "partner":"8ufj" }, - { - "sim":50.0, - "partner":"2wc4" - }, { "sim":50.0, "partner":"1oif" @@ -950163,16 +954321,20 @@ }, { "sim":50.0, - "partner":"6j0u" + "partner":"2wc4" }, { "sim":50.0, - "partner":"6ak4" + "partner":"6j0u" }, { "sim":50.0, "partner":"6aej" }, + { + "sim":50.0, + "partner":"6ak4" + }, { "sim":50.0, "partner":"4kc7" @@ -950187,11 +954349,11 @@ }, { "sim":50.0, - "partner":"4dqv" + "partner":"4u5q" }, { "sim":50.0, - "partner":"4u5q" + "partner":"4dqv" }, { "sim":50.0, @@ -950233,10 +954395,6 @@ "sim":50.0, "partner":"3udt" }, - { - "sim":50.0, - "partner":"4ie7" - }, { "sim":50.0, "partner":"4cxw" @@ -950255,15 +954413,15 @@ }, { "sim":50.0, - "partner":"4idz" + "partner":"7e8z" }, { "sim":50.0, - "partner":"4ie0" + "partner":"4idz" }, { "sim":50.0, - "partner":"7e8z" + "partner":"4ie0" }, { "sim":50.0, @@ -950281,6 +954439,10 @@ "sim":50.0, "partner":"4qho" }, + { + "sim":50.0, + "partner":"4ie7" + }, { "sim":50.0, "partner":"6u4z" @@ -950305,14 +954467,6 @@ "sim":50.0, "partner":"3n6r" }, - { - "sim":50.0, - "partner":"8aq3" - }, - { - "sim":50.0, - "partner":"8aq4" - }, { "sim":50.0, "partner":"7aci" @@ -950321,10 +954475,6 @@ "sim":50.0, "partner":"8b0k" }, - { - "sim":50.0, - "partner":"5n6h" - }, { "sim":50.0, "partner":"8b0l" @@ -950337,6 +954487,10 @@ "sim":50.0, "partner":"8b0n" }, + { + "sim":50.0, + "partner":"5n6h" + }, { "sim":50.0, "partner":"8b0o" @@ -950353,6 +954507,14 @@ "sim":50.0, "partner":"5n6l" }, + { + "sim":50.0, + "partner":"8aq3" + }, + { + "sim":50.0, + "partner":"8aq4" + }, { "sim":50.0, "partner":"7lha" @@ -950391,7 +954553,7 @@ }, { "sim":50.0, - "partner":"5m12" + "partner":"6gwg" }, { "sim":50.0, @@ -950399,31 +954561,31 @@ }, { "sim":50.0, - "partner":"6gwf" + "partner":"6gta" }, { "sim":50.0, - "partner":"6gwg" + "partner":"5m16" }, { "sim":50.0, - "partner":"5m16" + "partner":"6gvd" }, { "sim":50.0, - "partner":"6gta" + "partner":"5m0x" }, { "sim":50.0, - "partner":"6gvd" + "partner":"6gx8" }, { "sim":50.0, - "partner":"5m0x" + "partner":"5m12" }, { "sim":50.0, - "partner":"6gx8" + "partner":"6gwf" }, { "sim":50.0, @@ -950455,15 +954617,15 @@ }, { "sim":50.0, - "partner":"7w1c" + "partner":"7w1d" }, { "sim":50.0, - "partner":"7w1d" + "partner":"7w1e" }, { "sim":50.0, - "partner":"7w1e" + "partner":"7w1c" }, { "sim":50.0, @@ -950475,16 +954637,12 @@ }, { "sim":50.0, - "partner":"5uw0" + "partner":"5uw1" }, { "sim":50.0, "partner":"5vnc" }, - { - "sim":50.0, - "partner":"5uw1" - }, { "sim":50.0, "partner":"5uw4" @@ -950495,7 +954653,7 @@ }, { "sim":50.0, - "partner":"3rsz" + "partner":"5uw0" }, { "sim":50.0, @@ -950525,6 +954683,10 @@ "sim":50.0, "partner":"3nch" }, + { + "sim":50.0, + "partner":"3rsz" + }, { "sim":50.0, "partner":"8eax" @@ -950545,10 +954707,6 @@ "sim":50.0, "partner":"2wco" }, - { - "sim":50.0, - "partner":"6edw" - }, { "sim":50.0, "partner":"6edz" @@ -950559,19 +954717,11 @@ }, { "sim":50.0, - "partner":"8bou" - }, - { - "sim":50.0, - "partner":"3ahc" - }, - { - "sim":50.0, - "partner":"3ahd" + "partner":"6edw" }, { "sim":50.0, - "partner":"3ahe" + "partner":"8bou" }, { "sim":50.0, @@ -950595,11 +954745,15 @@ }, { "sim":50.0, - "partner":"4j3t" + "partner":"3ahc" }, { "sim":50.0, - "partner":"4j3u" + "partner":"3ahd" + }, + { + "sim":50.0, + "partner":"3ahe" }, { "sim":50.0, @@ -950617,6 +954771,14 @@ "sim":50.0, "partner":"4j3s" }, + { + "sim":50.0, + "partner":"4j3t" + }, + { + "sim":50.0, + "partner":"4j3u" + }, { "sim":50.0, "partner":"7s6b" @@ -950631,15 +954793,15 @@ }, { "sim":50.0, - "partner":"7o3m" + "partner":"7o3n" }, { "sim":50.0, - "partner":"7o3n" + "partner":"7o3l" }, { "sim":50.0, - "partner":"7o3l" + "partner":"7o3m" }, { "sim":50.0, @@ -950682,12 +954844,12 @@ "partner":"1sw3" }, { - "sim":0.9548000097, - "partner":"1tpv" + "sim":0.9539999962, + "partner":"1ssd" }, { - "sim":0.9550999999, - "partner":"1tpw" + "sim":0.9548000097, + "partner":"1tpv" }, { "sim":0.9552000165, @@ -950698,12 +954860,12 @@ "partner":"1tpc" }, { - "sim":0.9555000067, - "partner":"1tpb" + "sim":0.9550999999, + "partner":"1tpw" }, { - "sim":0.9539999962, - "partner":"1ssd" + "sim":0.9555000067, + "partner":"1tpb" } ], "seq_max_sim_designed":{ @@ -950774,123 +954936,123 @@ ], "subtitle":"Crystal structure of the worst case reconstruction of the ancestral triosephosphate isomerase of the last opisthokont common ancestor obtained by maximum likelihood", "tags":[ - "triosephosphate isomerase", + "isomerase", "ancestral sequence reconstruction", - "isomerase" + "triosephosphate isomerase" ], "keywords":[ - "work", - "tims", - "analysis", - "evolution", - "unfolding", - "lineages", - "evidence", - "oligomers", - "monomeric", - "located", - "part", - "bonds", - "conserved", - "test", - "isomerase", - "physicochemical", "opisthokonts", - "protozoan", - "reconstruction", - "sequences", - "robustness", - "equilibrium", - "structure", - "monomer", - "applied", - "oligomer", - "resembles", - "unstable", - "spectroscopic", + "tot", + "hydrodynamic", + "well", + "opisthokonta", + "presence", + "differences", + "bottom", + "locatims", "locatim", - "structured", - "reversible", - "resembling", - "reached", - "similar", - "infer", - "obligated", - "calorimetric", + "unstable", + "parameters", + "resembles", + "physicochemical", + "study", "indicated", - "although", - "strongly", - "locatims", - "presence", - "used", - "ancestral", - "comparative", - "structures", - "transitions", - "function", + "unfolding", "showed", - "triosephosphate", - "intermediates", + "equilibrium", "extensive", + "test", + "catalytic", + "two", + "infer", + "lineages", + "similar", + "worst", + "reconstructed", "shows", - "coupled", + "conformational", + "isomerase", + "ones", + "intermediates", + "although", + "last", + "case", + "strongly", + "triosephosphate", + "stability", + "part", + "evidence", + "characterization", + "several", + "ancestral", "hydrogen", "inference", - "properties", - "previously", - "stability", - "monomers", - "bottom", + "found", + "reached", + "\u03b4g", + "resembling", + "evolution", "higher", - "common", - "worst", - "methodologies", - "catalytic", - "temperature", - "four", - "unf", "diverged", - "observed", - "several", - "melting", - "characterization", - "confidence", - "rather", - "\u03b4g", - "high", - "sequence", - "parameters", + "robustness", + "four", + "monomer", + "barrel", + "correlation", "increase", + "spectroscopic", + "calorimetric", + "work", + "used", "extant", - "notably", - "ancestor", - "ones", - "tim", - "hydrodynamic", + "different", + "transitions", + "monomers", + "properties", + "bonds", + "also", + "reversible", + "confidence", + "inactive", + "methodologies", + "oligomer", + "unf", "plausible", + "notably", + "sequence", + "applied", + "common", "3d", - "opisthokonta", - "conformational", - "estimated", - "also", - "study", + "analysis", + "coupled", + "sequences", + "comparative", + "conserved", + "rather", + "observed", + "structures", + "reconstruction", + "oligomers", + "previously", + "structured", + "structure", + "monomeric", "fungi", - "barrel", - "tot", - "well", - "last", - "different", - "found", - "two", - "reconstructed", - "inactive", + "scenario", + "temperature", + "biophysical", + "function", + "melting", + "obligated", "energetics", + "located", + "high", + "estimated", + "tim", + "tims", + "ancestor", "animals", - "differences", - "scenario", - "case", - "correlation", - "biophysical" + "protozoan" ], "release_date":"2024-09-04", "publication":"\"Stable monomers in the ancestral sequence reconstruction of the last opisthokont common ancestor of dimeric triosephosphate isomerase\", Protein Sci., 33, e5134-e5134", @@ -950927,19 +955089,19 @@ }, { "sim":522.0, - "partner":"8w06" + "partner":"8w05" }, { "sim":522.0, - "partner":"8w05" + "partner":"8w06" }, { "sim":489.0, - "partner":"8v2w" + "partner":"8v09" }, { "sim":489.0, - "partner":"8v09" + "partner":"8v2w" }, { "sim":483.0, @@ -950955,11 +955117,11 @@ }, { "sim":51.0, - "partner":"8c66" + "partner":"8adx" }, { "sim":51.0, - "partner":"8adx" + "partner":"8c66" }, { "sim":50.0, @@ -950971,11 +955133,11 @@ }, { "sim":50.0, - "partner":"8jpa" + "partner":"8hdv" }, { "sim":50.0, - "partner":"8hdv" + "partner":"8jpa" }, { "sim":50.0, @@ -951073,11 +955235,11 @@ }, { "sim":344.0, - "partner":"8tim" + "partner":"1tph" }, { "sim":344.0, - "partner":"1tph" + "partner":"8tim" }, { "sim":344.0, @@ -951117,27 +955279,27 @@ }, { "sim":342.0, - "partner":"1r2s" + "partner":"4owg" }, { "sim":342.0, - "partner":"1r2t" + "partner":"4unl" }, { "sim":342.0, - "partner":"4owg" + "partner":"1r2r" }, { "sim":342.0, - "partner":"4unl" + "partner":"1hti" }, { "sim":342.0, - "partner":"1hti" + "partner":"1r2s" }, { "sim":342.0, - "partner":"1r2r" + "partner":"1r2t" }, { "sim":342.0, @@ -951265,27 +955427,27 @@ }, { "sim":312.0, - "partner":"8j7c" + "partner":"4gnj" }, { "sim":312.0, - "partner":"8jbp" + "partner":"8j7c" }, { "sim":312.0, - "partner":"4gnj" + "partner":"8jbp" }, { "sim":306.0, - "partner":"2ypi" + "partner":"1ypi" }, { "sim":306.0, - "partner":"1ypi" + "partner":"7tim" }, { "sim":306.0, - "partner":"7tim" + "partner":"2ypi" }, { "sim":304.0, @@ -951301,11 +955463,11 @@ }, { "sim":298.0, - "partner":"1nf0" + "partner":"1ney" }, { "sim":298.0, - "partner":"1ney" + "partner":"1nf0" }, { "sim":295.0, @@ -951325,11 +955487,11 @@ }, { "sim":281.0, - "partner":"4o50" + "partner":"4o53" }, { "sim":281.0, - "partner":"4o53" + "partner":"4o50" }, { "sim":280.0, @@ -951357,51 +955519,51 @@ }, { "sim":278.0, - "partner":"7az3" + "partner":"1n55" }, { "sim":278.0, - "partner":"2vxn" + "partner":"7az9" }, { "sim":278.0, - "partner":"7az4" + "partner":"7aza" }, { "sim":278.0, - "partner":"1n55" + "partner":"2y61" }, { "sim":278.0, - "partner":"7az9" + "partner":"2y62" }, { "sim":278.0, - "partner":"7aza" + "partner":"2y63" }, { "sim":278.0, - "partner":"2y61" + "partner":"7abx" }, { "sim":278.0, - "partner":"2y62" + "partner":"7az3" }, { "sim":278.0, - "partner":"2y63" + "partner":"1qds" }, { "sim":278.0, - "partner":"1if2" + "partner":"7az4" }, { "sim":278.0, - "partner":"7abx" + "partner":"1if2" }, { "sim":278.0, - "partner":"1qds" + "partner":"2vxn" }, { "sim":277.0, @@ -951431,10 +955593,6 @@ "sim":273.0, "partner":"1iig" }, - { - "sim":273.0, - "partner":"2v0t" - }, { "sim":273.0, "partner":"4jeq" @@ -951449,11 +955607,11 @@ }, { "sim":273.0, - "partner":"1ag1" + "partner":"2oma" }, { "sim":273.0, - "partner":"2oma" + "partner":"1ag1" }, { "sim":273.0, @@ -951473,15 +955631,19 @@ }, { "sim":273.0, - "partner":"4tim" + "partner":"2v0t" }, { "sim":273.0, - "partner":"2v5l" + "partner":"6tim" }, { "sim":273.0, - "partner":"6tim" + "partner":"4tim" + }, + { + "sim":273.0, + "partner":"2v5l" }, { "sim":273.0, @@ -951513,23 +955675,23 @@ }, { "sim":271.0, - "partner":"1kv5" + "partner":"5i3j" }, { "sim":271.0, - "partner":"5i3i" + "partner":"5i3k" }, { "sim":271.0, - "partner":"5i3j" + "partner":"5i3f" }, { "sim":271.0, - "partner":"5i3k" + "partner":"5i3i" }, { "sim":271.0, - "partner":"5i3f" + "partner":"1kv5" }, { "sim":271.0, @@ -951595,10 +955757,6 @@ "sim":257.0, "partner":"2vfe" }, - { - "sim":256.0, - "partner":"1lzo" - }, { "sim":256.0, "partner":"1lyx" @@ -951635,6 +955793,10 @@ "sim":256.0, "partner":"1m7o" }, + { + "sim":256.0, + "partner":"1lzo" + }, { "sim":256.0, "partner":"1m7p" @@ -951685,11 +955847,11 @@ }, { "sim":253.0, - "partner":"5gv4" + "partner":"5gzp" }, { "sim":253.0, - "partner":"5gzp" + "partner":"5gv4" }, { "sim":252.0, @@ -951819,10 +955981,6 @@ "sim":228.0, "partner":"4y96" }, - { - "sim":228.0, - "partner":"3uwz" - }, { "sim":228.0, "partner":"3uwu" @@ -951839,6 +955997,10 @@ "sim":228.0, "partner":"3uwy" }, + { + "sim":228.0, + "partner":"3uwz" + }, { "sim":222.0, "partner":"4mva" @@ -951865,11 +956027,11 @@ }, { "sim":210.0, - "partner":"4iot" + "partner":"1tre" }, { "sim":210.0, - "partner":"1tre" + "partner":"4iot" }, { "sim":204.0, @@ -952153,43 +956315,39 @@ }, { "sim":55.0, - "partner":"5y0f" - }, - { - "sim":55.0, - "partner":"5y0g" + "partner":"4nns" }, { "sim":55.0, - "partner":"4nns" + "partner":"4nnt" }, { "sim":55.0, - "partner":"4nnt" + "partner":"6ljs" }, { "sim":55.0, - "partner":"5y12" + "partner":"6ljt" }, { "sim":55.0, - "partner":"6ljs" + "partner":"8wdx" }, { "sim":55.0, - "partner":"5d45" + "partner":"5y12" }, { "sim":55.0, - "partner":"5y13" + "partner":"6lju" }, { "sim":55.0, - "partner":"6ljt" + "partner":"5d45" }, { "sim":55.0, - "partner":"6lju" + "partner":"5y13" }, { "sim":55.0, @@ -952213,7 +956371,7 @@ }, { "sim":55.0, - "partner":"8wdx" + "partner":"8we3" }, { "sim":55.0, @@ -952225,11 +956383,15 @@ }, { "sim":55.0, - "partner":"8we3" + "partner":"5y0x" }, { "sim":55.0, - "partner":"5y0x" + "partner":"5y0f" + }, + { + "sim":55.0, + "partner":"5y0g" }, { "sim":55.0, @@ -952247,10 +956409,6 @@ "sim":55.0, "partner":"8fuh" }, - { - "sim":55.0, - "partner":"3th5" - }, { "sim":55.0, "partner":"4gzl" @@ -952279,6 +956437,10 @@ "sim":55.0, "partner":"3zf6" }, + { + "sim":55.0, + "partner":"3th5" + }, { "sim":55.0, "partner":"8spb" @@ -952335,10 +956497,6 @@ "sim":55.0, "partner":"4xkm" }, - { - "sim":55.0, - "partner":"2cj9" - }, { "sim":55.0, "partner":"2cja" @@ -952351,6 +956509,10 @@ "sim":55.0, "partner":"2cjb" }, + { + "sim":55.0, + "partner":"2cj9" + }, { "sim":55.0, "partner":"5a6j" @@ -952417,11 +956579,11 @@ }, { "sim":54.0, - "partner":"3la8" + "partner":"3lba" }, { "sim":54.0, - "partner":"3lba" + "partner":"3la8" }, { "sim":54.0, @@ -952443,10 +956605,6 @@ "sim":54.0, "partner":"5v8y" }, - { - "sim":54.0, - "partner":"5jyf" - }, { "sim":54.0, "partner":"5v8x" @@ -952475,6 +956633,10 @@ "sim":54.0, "partner":"5jye" }, + { + "sim":54.0, + "partner":"5jyf" + }, { "sim":54.0, "partner":"1v33" @@ -952529,15 +956691,15 @@ }, { "sim":53.0, - "partner":"3vwb" + "partner":"3w2a" }, { "sim":53.0, - "partner":"3w2a" + "partner":"3w3c" }, { "sim":53.0, - "partner":"3w3c" + "partner":"3vwb" }, { "sim":53.0, @@ -952625,15 +956787,15 @@ }, { "sim":53.0, - "partner":"6j0l" + "partner":"6j0g" }, { "sim":53.0, - "partner":"6j0g" + "partner":"6j0k" }, { "sim":53.0, - "partner":"6j0k" + "partner":"6j0l" }, { "sim":53.0, @@ -952649,23 +956811,23 @@ }, { "sim":53.0, - "partner":"6ihr" + "partner":"6ihv" }, { "sim":53.0, - "partner":"6iht" + "partner":"6ihw" }, { "sim":53.0, - "partner":"6ihu" + "partner":"6ihr" }, { "sim":53.0, - "partner":"6ihv" + "partner":"6iht" }, { "sim":53.0, - "partner":"6ihw" + "partner":"6ihu" }, { "sim":53.0, @@ -952731,10 +956893,6 @@ "sim":53.0, "partner":"3t95" }, - { - "sim":53.0, - "partner":"2ikf" - }, { "sim":53.0, "partner":"2q0c" @@ -952763,6 +956921,10 @@ "sim":53.0, "partner":"5kal" }, + { + "sim":53.0, + "partner":"2ikf" + }, { "sim":53.0, "partner":"8hmn" @@ -952783,10 +956945,6 @@ "sim":53.0, "partner":"4ocv" }, - { - "sim":53.0, - "partner":"3pz9" - }, { "sim":53.0, "partner":"3pzg" @@ -952811,6 +956969,10 @@ "sim":53.0, "partner":"3pzq" }, + { + "sim":53.0, + "partner":"3pz9" + }, { "sim":53.0, "partner":"4w61" @@ -952869,15 +957031,15 @@ }, { "sim":53.0, - "partner":"7mdl" + "partner":"8g9z" }, { "sim":53.0, - "partner":"8g9z" + "partner":"7l1t" }, { "sim":53.0, - "partner":"7l1t" + "partner":"7mdl" }, { "sim":53.0, @@ -952893,11 +957055,11 @@ }, { "sim":53.0, - "partner":"2vbg" + "partner":"2vbf" }, { "sim":53.0, - "partner":"2vbf" + "partner":"2vbg" }, { "sim":53.0, @@ -952959,10 +957121,6 @@ "sim":52.0, "partner":"7rrm" }, - { - "sim":52.0, - "partner":"5zrk" - }, { "sim":52.0, "partner":"5zrl" @@ -952991,6 +957149,10 @@ "sim":52.0, "partner":"5zri" }, + { + "sim":52.0, + "partner":"5zrk" + }, { "sim":52.0, "partner":"7xtl" @@ -953001,19 +957163,19 @@ }, { "sim":52.0, - "partner":"1x24" + "partner":"4gzd" }, { "sim":52.0, - "partner":"4gzc" + "partner":"1zcl" }, { "sim":52.0, - "partner":"4gzd" + "partner":"1x24" }, { "sim":52.0, - "partner":"1zcl" + "partner":"4gzc" }, { "sim":52.0, @@ -953045,11 +957207,11 @@ }, { "sim":52.0, - "partner":"6kz6" + "partner":"8be9" }, { "sim":52.0, - "partner":"8be9" + "partner":"6kz6" }, { "sim":52.0, @@ -953075,10 +957237,6 @@ "sim":52.0, "partner":"3vwv" }, - { - "sim":52.0, - "partner":"6ueo" - }, { "sim":52.0, "partner":"6uep" @@ -953091,6 +957249,10 @@ "sim":52.0, "partner":"6uer" }, + { + "sim":52.0, + "partner":"6ueo" + }, { "sim":52.0, "partner":"4wqo" @@ -953105,19 +957267,19 @@ }, { "sim":52.0, - "partner":"4bmx" + "partner":"4bmz" }, { "sim":52.0, - "partner":"4bmy" + "partner":"4bn0" }, { "sim":52.0, - "partner":"4bmz" + "partner":"4bmx" }, { "sim":52.0, - "partner":"4bn0" + "partner":"4bmy" }, { "sim":52.0, @@ -953191,10 +957353,6 @@ "sim":52.0, "partner":"5hru" }, - { - "sim":52.0, - "partner":"7dw8" - }, { "sim":52.0, "partner":"7dwa" @@ -953209,11 +957367,11 @@ }, { "sim":52.0, - "partner":"7js3" + "partner":"8g5w" }, { "sim":52.0, - "partner":"8g5w" + "partner":"7js3" }, { "sim":52.0, @@ -953223,13 +957381,17 @@ "sim":52.0, "partner":"7txa" }, + { + "sim":52.0, + "partner":"7dvj" + }, { "sim":52.0, "partner":"7txg" }, { "sim":52.0, - "partner":"7dvj" + "partner":"7dw8" }, { "sim":52.0, @@ -953255,10 +957417,6 @@ "sim":52.0, "partner":"4rhq" }, - { - "sim":52.0, - "partner":"5g6t" - }, { "sim":52.0, "partner":"5g5u" @@ -953289,11 +957447,11 @@ }, { "sim":52.0, - "partner":"5xmd" + "partner":"5g6t" }, { "sim":52.0, - "partner":"7ajm" + "partner":"5xmd" }, { "sim":52.0, @@ -953309,23 +957467,7 @@ }, { "sim":52.0, - "partner":"7a53" - }, - { - "sim":52.0, - "partner":"7ajw" - }, - { - "sim":52.0, - "partner":"7akb" - }, - { - "sim":52.0, - "partner":"7ajy" - }, - { - "sim":52.0, - "partner":"7a5l" + "partner":"7ajm" }, { "sim":52.0, @@ -953391,25 +957533,37 @@ "sim":52.0, "partner":"7aka" }, + { + "sim":52.0, + "partner":"7a53" + }, { "sim":52.0, "partner":"7akl" }, { "sim":52.0, - "partner":"5uqv" + "partner":"7ajw" }, { "sim":52.0, - "partner":"5uqx" + "partner":"7akb" }, { "sim":52.0, - "partner":"8wov" + "partner":"7ajy" }, { "sim":52.0, - "partner":"8wow" + "partner":"7a5l" + }, + { + "sim":52.0, + "partner":"5uqv" + }, + { + "sim":52.0, + "partner":"5uqx" }, { "sim":52.0, @@ -953417,7 +957571,11 @@ }, { "sim":52.0, - "partner":"3c1y" + "partner":"8wov" + }, + { + "sim":52.0, + "partner":"8wow" }, { "sim":52.0, @@ -953439,6 +957597,10 @@ "sim":52.0, "partner":"4yvz" }, + { + "sim":52.0, + "partner":"3c1y" + }, { "sim":52.0, "partner":"3rpl" @@ -953485,15 +957647,15 @@ }, { "sim":52.0, - "partner":"5dvi" + "partner":"5dvj" }, { "sim":52.0, - "partner":"5dvj" + "partner":"5dvf" }, { "sim":52.0, - "partner":"5dvf" + "partner":"5dvi" }, { "sim":52.0, @@ -953511,14 +957673,6 @@ "sim":52.0, "partner":"5y9h" }, - { - "sim":52.0, - "partner":"6mlh" - }, - { - "sim":52.0, - "partner":"6mlw" - }, { "sim":52.0, "partner":"6nn1" @@ -953543,6 +957697,14 @@ "sim":52.0, "partner":"6mlf" }, + { + "sim":52.0, + "partner":"6mlh" + }, + { + "sim":52.0, + "partner":"6mlw" + }, { "sim":52.0, "partner":"7dtp" @@ -953661,11 +957823,11 @@ }, { "sim":52.0, - "partner":"3l7r" + "partner":"3t0c" }, { "sim":52.0, - "partner":"3t0c" + "partner":"3l7r" }, { "sim":52.0, @@ -953715,10 +957877,6 @@ "sim":51.0, "partner":"2l6m" }, - { - "sim":51.0, - "partner":"4hmr" - }, { "sim":51.0, "partner":"4hls" @@ -953731,6 +957889,10 @@ "sim":51.0, "partner":"1yx3" }, + { + "sim":51.0, + "partner":"4hmr" + }, { "sim":51.0, "partner":"5h34" @@ -953753,11 +957915,11 @@ }, { "sim":51.0, - "partner":"6isk" + "partner":"6isl" }, { "sim":51.0, - "partner":"6isl" + "partner":"6isk" }, { "sim":51.0, @@ -953831,10 +957993,6 @@ "sim":51.0, "partner":"5e3b" }, - { - "sim":51.0, - "partner":"7ccl" - }, { "sim":51.0, "partner":"7ccm" @@ -953855,6 +958013,10 @@ "sim":51.0, "partner":"7efx" }, + { + "sim":51.0, + "partner":"7ccl" + }, { "sim":51.0, "partner":"5zba" @@ -953915,10 +958077,6 @@ "sim":51.0, "partner":"2iss" }, - { - "sim":51.0, - "partner":"3l1u" - }, { "sim":51.0, "partner":"3l1v" @@ -953939,6 +958097,10 @@ "sim":51.0, "partner":"3esr" }, + { + "sim":51.0, + "partner":"3l1u" + }, { "sim":51.0, "partner":"6a4c" @@ -953953,15 +958115,15 @@ }, { "sim":51.0, - "partner":"3wyd" + "partner":"7rm7" }, { "sim":51.0, - "partner":"7rm7" + "partner":"7snb" }, { "sim":51.0, - "partner":"7snb" + "partner":"3wyd" }, { "sim":51.0, @@ -953989,19 +958151,19 @@ }, { "sim":51.0, - "partner":"8vip" + "partner":"8vit" }, { "sim":51.0, - "partner":"8viq" + "partner":"8vip" }, { "sim":51.0, - "partner":"8vir" + "partner":"8viq" }, { "sim":51.0, - "partner":"8vit" + "partner":"8vir" }, { "sim":51.0, @@ -954061,11 +958223,11 @@ }, { "sim":51.0, - "partner":"5h5a" + "partner":"5h54" }, { "sim":51.0, - "partner":"5h54" + "partner":"5h5a" }, { "sim":51.0, @@ -954187,14 +958349,6 @@ "sim":51.0, "partner":"3u4d" }, - { - "sim":51.0, - "partner":"3quo" - }, - { - "sim":51.0, - "partner":"3qvf" - }, { "sim":51.0, "partner":"3qur" @@ -954223,6 +958377,14 @@ "sim":51.0, "partner":"3qun" }, + { + "sim":51.0, + "partner":"3quo" + }, + { + "sim":51.0, + "partner":"3qvf" + }, { "sim":51.0, "partner":"3jyy" @@ -954283,10 +958445,6 @@ "sim":51.0, "partner":"6m0a" }, - { - "sim":51.0, - "partner":"6wye" - }, { "sim":51.0, "partner":"2jfo" @@ -954307,6 +958465,10 @@ "sim":51.0, "partner":"4ats" }, + { + "sim":51.0, + "partner":"6wye" + }, { "sim":51.0, "partner":"7umj" @@ -954353,11 +958515,11 @@ }, { "sim":51.0, - "partner":"6aa8" + "partner":"7eov" }, { "sim":51.0, - "partner":"7eov" + "partner":"6aa8" }, { "sim":51.0, @@ -954369,35 +958531,35 @@ }, { "sim":51.0, - "partner":"7xif" + "partner":"7xig" }, { "sim":51.0, - "partner":"8wlb" + "partner":"8wl5" }, { "sim":51.0, - "partner":"7xig" + "partner":"8wl7" }, { "sim":51.0, - "partner":"7xih" + "partner":"8wl9" }, { "sim":51.0, - "partner":"7xii" + "partner":"7xih" }, { "sim":51.0, - "partner":"8wl5" + "partner":"8wlb" }, { "sim":51.0, - "partner":"8wl7" + "partner":"7xii" }, { "sim":51.0, - "partner":"8wl9" + "partner":"7xif" }, { "sim":51.0, @@ -954409,11 +958571,11 @@ }, { "sim":51.0, - "partner":"3zgd" + "partner":"7dt2" }, { "sim":51.0, - "partner":"7dt2" + "partner":"3zgd" }, { "sim":51.0, @@ -954433,51 +958595,51 @@ }, { "sim":51.0, - "partner":"7q2b" + "partner":"7q2f" }, { "sim":51.0, - "partner":"3ha3" + "partner":"7q2g" }, { "sim":51.0, - "partner":"7q2c" + "partner":"7q2h" }, { "sim":51.0, - "partner":"7q2d" + "partner":"3ha5" }, { "sim":51.0, - "partner":"7q2e" + "partner":"2fk7" }, { "sim":51.0, - "partner":"7q2f" + "partner":"2fk8" }, { "sim":51.0, - "partner":"7q2g" + "partner":"3ha7" }, { "sim":51.0, - "partner":"7q2h" + "partner":"7q2b" }, { "sim":51.0, - "partner":"3ha5" + "partner":"7q2c" }, { "sim":51.0, - "partner":"2fk7" + "partner":"3ha3" }, { "sim":51.0, - "partner":"2fk8" + "partner":"7q2d" }, { "sim":51.0, - "partner":"3ha7" + "partner":"7q2e" }, { "sim":51.0, @@ -954587,10 +958749,6 @@ "sim":51.0, "partner":"7ohn" }, - { - "sim":51.0, - "partner":"5mit" - }, { "sim":51.0, "partner":"5mjk" @@ -954617,15 +958775,11 @@ }, { "sim":51.0, - "partner":"7x1l" - }, - { - "sim":51.0, - "partner":"4w7v" + "partner":"5mit" }, { "sim":51.0, - "partner":"4w7w" + "partner":"7x1l" }, { "sim":51.0, @@ -954647,6 +958801,14 @@ "sim":51.0, "partner":"4w7u" }, + { + "sim":51.0, + "partner":"4w7v" + }, + { + "sim":51.0, + "partner":"4w7w" + }, { "sim":51.0, "partner":"6q75" @@ -954699,14 +958861,6 @@ "sim":51.0, "partner":"5hpc" }, - { - "sim":51.0, - "partner":"4fif" - }, - { - "sim":51.0, - "partner":"7s46" - }, { "sim":51.0, "partner":"4fig" @@ -954749,11 +958903,11 @@ }, { "sim":51.0, - "partner":"3rny" + "partner":"6wlx" }, { "sim":51.0, - "partner":"6wlx" + "partner":"3rny" }, { "sim":51.0, @@ -954761,12 +958915,20 @@ }, { "sim":51.0, - "partner":"6sf5" + "partner":"4fif" + }, + { + "sim":51.0, + "partner":"7s46" }, { "sim":51.0, "partner":"6sf4" }, + { + "sim":51.0, + "partner":"6sf5" + }, { "sim":51.0, "partner":"3ren" @@ -954895,10 +959057,6 @@ "sim":51.0, "partner":"7us5" }, - { - "sim":51.0, - "partner":"4m1i" - }, { "sim":51.0, "partner":"4d8f" @@ -954913,19 +959071,7 @@ }, { "sim":51.0, - "partner":"7wxl" - }, - { - "sim":51.0, - "partner":"7wxm" - }, - { - "sim":51.0, - "partner":"7wxn" - }, - { - "sim":51.0, - "partner":"7wxo" + "partner":"4m1i" }, { "sim":51.0, @@ -954955,6 +959101,22 @@ "sim":51.0, "partner":"7wxk" }, + { + "sim":51.0, + "partner":"7wxl" + }, + { + "sim":51.0, + "partner":"7wxm" + }, + { + "sim":51.0, + "partner":"7wxn" + }, + { + "sim":51.0, + "partner":"7wxo" + }, { "sim":51.0, "partner":"4o6e" @@ -954973,11 +959135,11 @@ }, { "sim":51.0, - "partner":"5f5m" + "partner":"5f5o" }, { "sim":51.0, - "partner":"5f5o" + "partner":"5f5m" }, { "sim":51.0, @@ -954987,10 +959149,6 @@ "sim":51.0, "partner":"2yvk" }, - { - "sim":51.0, - "partner":"4zhs" - }, { "sim":51.0, "partner":"4oco" @@ -955017,19 +959175,19 @@ }, { "sim":51.0, - "partner":"4ltz" + "partner":"4zhs" }, { "sim":51.0, - "partner":"7kj8" + "partner":"3kbk" }, { "sim":51.0, - "partner":"7kj9" + "partner":"6ax9" }, { "sim":51.0, - "partner":"3kbk" + "partner":"7kjd" }, { "sim":51.0, @@ -955037,7 +959195,7 @@ }, { "sim":51.0, - "partner":"6ax9" + "partner":"7kje" }, { "sim":51.0, @@ -955045,39 +959203,31 @@ }, { "sim":51.0, - "partner":"8su2" - }, - { - "sim":51.0, - "partner":"8su3" - }, - { - "sim":51.0, - "partner":"7kjd" + "partner":"6axu" }, { "sim":51.0, - "partner":"8su4" + "partner":"7kjf" }, { "sim":51.0, - "partner":"6axu" + "partner":"8su2" }, { "sim":51.0, - "partner":"7kje" + "partner":"7kjg" }, { "sim":51.0, - "partner":"8su5" + "partner":"8su3" }, { "sim":51.0, - "partner":"7kjf" + "partner":"8v3k" }, { "sim":51.0, - "partner":"7kjg" + "partner":"8su4" }, { "sim":51.0, @@ -955085,11 +959235,11 @@ }, { "sim":51.0, - "partner":"3kb9" + "partner":"8su5" }, { "sim":51.0, - "partner":"8v3k" + "partner":"3kb9" }, { "sim":51.0, @@ -955127,6 +959277,18 @@ "sim":51.0, "partner":"4luu" }, + { + "sim":51.0, + "partner":"7kj8" + }, + { + "sim":51.0, + "partner":"4ltz" + }, + { + "sim":51.0, + "partner":"7kj9" + }, { "sim":51.0, "partner":"3fvm" @@ -955183,21 +959345,17 @@ "sim":51.0, "partner":"3k01" }, - { - "sim":51.0, - "partner":"2gqn" - }, { "sim":51.0, "partner":"2fq6" }, { "sim":51.0, - "partner":"7bvt" + "partner":"2gqn" }, { "sim":51.0, - "partner":"4euh" + "partner":"7bvt" }, { "sim":51.0, @@ -955215,6 +959373,10 @@ "sim":51.0, "partner":"4euf" }, + { + "sim":51.0, + "partner":"4euh" + }, { "sim":51.0, "partner":"5hxk" @@ -955251,10 +959413,6 @@ "sim":51.0, "partner":"7ui4" }, - { - "sim":51.0, - "partner":"4q6q" - }, { "sim":51.0, "partner":"4q6m" @@ -955273,24 +959431,28 @@ }, { "sim":51.0, - "partner":"6v99" + "partner":"4q6q" }, { "sim":51.0, - "partner":"6v9a" + "partner":"6v96" }, { "sim":51.0, - "partner":"6v96" + "partner":"6v99" }, { "sim":51.0, - "partner":"7lr2" + "partner":"6v9a" }, { "sim":51.0, "partner":"7lr1" }, + { + "sim":51.0, + "partner":"7lr2" + }, { "sim":51.0, "partner":"5ctt" @@ -955335,10 +959497,6 @@ "sim":51.0, "partner":"7tf9" }, - { - "sim":51.0, - "partner":"6oi8" - }, { "sim":51.0, "partner":"4mv1" @@ -955377,11 +959535,7 @@ }, { "sim":51.0, - "partner":"2gps" - }, - { - "sim":51.0, - "partner":"6oi9" + "partner":"6oi8" }, { "sim":51.0, @@ -955399,6 +959553,14 @@ "sim":51.0, "partner":"6pso" }, + { + "sim":51.0, + "partner":"2gps" + }, + { + "sim":51.0, + "partner":"6oi9" + }, { "sim":51.0, "partner":"6wiu" @@ -955413,15 +959575,15 @@ }, { "sim":51.0, - "partner":"6x0h" + "partner":"6x0j" }, { "sim":51.0, - "partner":"6x0j" + "partner":"6x0k" }, { "sim":51.0, - "partner":"6x0k" + "partner":"6x0h" }, { "sim":51.0, @@ -955449,15 +959611,15 @@ }, { "sim":51.0, - "partner":"4dqw" + "partner":"6gjv" }, { "sim":51.0, - "partner":"6gjv" + "partner":"6gk9" }, { "sim":51.0, - "partner":"6gk9" + "partner":"4dqw" }, { "sim":51.0, @@ -955527,10 +959689,6 @@ "sim":51.0, "partner":"6gnf" }, - { - "sim":51.0, - "partner":"5wm2" - }, { "sim":51.0, "partner":"5wm3" @@ -955551,6 +959709,10 @@ "sim":51.0, "partner":"5wm7" }, + { + "sim":51.0, + "partner":"5wm2" + }, { "sim":51.0, "partner":"3bdl" @@ -955585,11 +959747,11 @@ }, { "sim":51.0, - "partner":"3i39" + "partner":"7err" }, { "sim":51.0, - "partner":"7err" + "partner":"3i39" }, { "sim":51.0, @@ -955685,35 +959847,35 @@ }, { "sim":51.0, - "partner":"3ahc" + "partner":"3ahf" }, { "sim":51.0, - "partner":"3ahd" + "partner":"3ahg" }, { "sim":51.0, - "partner":"3ahe" + "partner":"3ahh" }, { "sim":51.0, - "partner":"3ahf" + "partner":"3ahi" }, { "sim":51.0, - "partner":"3ahg" + "partner":"3ahj" }, { "sim":51.0, - "partner":"3ahh" + "partner":"3ahc" }, { "sim":51.0, - "partner":"3ahi" + "partner":"3ahd" }, { "sim":51.0, - "partner":"3ahj" + "partner":"3ahe" }, { "sim":51.0, @@ -955821,11 +959983,11 @@ }, { "sim":50.0, - "partner":"2jop" + "partner":"1te4" }, { "sim":50.0, - "partner":"1te4" + "partner":"2jop" }, { "sim":50.0, @@ -955877,11 +960039,11 @@ }, { "sim":50.0, - "partner":"3n39" + "partner":"3n3a" }, { "sim":50.0, - "partner":"3n3a" + "partner":"6lyx" }, { "sim":50.0, @@ -955889,11 +960051,11 @@ }, { "sim":50.0, - "partner":"6lyx" + "partner":"4elz" }, { "sim":50.0, - "partner":"4elz" + "partner":"3n39" }, { "sim":50.0, @@ -956095,10 +960257,6 @@ "sim":50.0, "partner":"2ntm" }, - { - "sim":50.0, - "partner":"5wps" - }, { "sim":50.0, "partner":"5wpu" @@ -956131,6 +960289,10 @@ "sim":50.0, "partner":"5wpr" }, + { + "sim":50.0, + "partner":"5wps" + }, { "sim":50.0, "partner":"4ykb" @@ -956211,10 +960373,6 @@ "sim":50.0, "partner":"5owf" }, - { - "sim":50.0, - "partner":"5tgs" - }, { "sim":50.0, "partner":"8w8h" @@ -956225,7 +960383,7 @@ }, { "sim":50.0, - "partner":"6t2r" + "partner":"5tgs" }, { "sim":50.0, @@ -956233,12 +960391,16 @@ }, { "sim":50.0, - "partner":"6ubb" + "partner":"6t2r" }, { "sim":50.0, "partner":"6ub8" }, + { + "sim":50.0, + "partner":"6ubb" + }, { "sim":50.0, "partner":"6uba" @@ -956269,11 +960431,11 @@ }, { "sim":50.0, - "partner":"6hxo" + "partner":"6hxn" }, { "sim":50.0, - "partner":"6hxn" + "partner":"6hxo" }, { "sim":50.0, @@ -956281,15 +960443,15 @@ }, { "sim":50.0, - "partner":"2wk1" + "partner":"6ypa" }, { "sim":50.0, - "partner":"6ypa" + "partner":"6akv" }, { "sim":50.0, - "partner":"6akv" + "partner":"2wk1" }, { "sim":50.0, @@ -956297,11 +960459,11 @@ }, { "sim":50.0, - "partner":"4rni" + "partner":"4rnj" }, { "sim":50.0, - "partner":"4rnj" + "partner":"4rni" }, { "sim":50.0, @@ -956367,10 +960529,6 @@ "sim":50.0, "partner":"6cng" }, - { - "sim":50.0, - "partner":"3s3h" - }, { "sim":50.0, "partner":"4gxn" @@ -956395,6 +960553,10 @@ "sim":50.0, "partner":"4gw3" }, + { + "sim":50.0, + "partner":"3s3h" + }, { "sim":50.0, "partner":"3nib" @@ -956415,10 +960577,6 @@ "sim":50.0, "partner":"1g93" }, - { - "sim":50.0, - "partner":"3g3d" - }, { "sim":50.0, "partner":"3bvj" @@ -956435,6 +960593,10 @@ "sim":50.0, "partner":"4hkp" }, + { + "sim":50.0, + "partner":"3g3d" + }, { "sim":50.0, "partner":"5mqv" @@ -956445,23 +960607,23 @@ }, { "sim":50.0, - "partner":"5zmy" + "partner":"6f1w" }, { "sim":50.0, - "partner":"6f1w" + "partner":"5zmy" }, { "sim":50.0, - "partner":"3b3d" + "partner":"7nzy" }, { "sim":50.0, - "partner":"5okt" + "partner":"3b3d" }, { "sim":50.0, - "partner":"7nzy" + "partner":"5okt" }, { "sim":50.0, @@ -956477,19 +960639,19 @@ }, { "sim":50.0, - "partner":"8u05" + "partner":"6l86" }, { "sim":50.0, - "partner":"8u06" + "partner":"8u05" }, { "sim":50.0, - "partner":"8u07" + "partner":"8u06" }, { "sim":50.0, - "partner":"6l86" + "partner":"8u07" }, { "sim":50.0, @@ -956535,10 +960697,6 @@ "sim":50.0, "partner":"5i0k" }, - { - "sim":50.0, - "partner":"3aio" - }, { "sim":50.0, "partner":"3aik" @@ -956559,6 +960717,10 @@ "sim":50.0, "partner":"3ain" }, + { + "sim":50.0, + "partner":"3aio" + }, { "sim":50.0, "partner":"5l84" @@ -956585,19 +960747,19 @@ }, { "sim":50.0, - "partner":"2pzm" + "partner":"2pzk" }, { "sim":50.0, - "partner":"2pzk" + "partner":"2pzl" }, { "sim":50.0, - "partner":"2pzl" + "partner":"2pzm" }, { "sim":50.0, - "partner":"6lcn" + "partner":"7bsx" }, { "sim":50.0, @@ -956605,11 +960767,11 @@ }, { "sim":50.0, - "partner":"7bsx" + "partner":"3h7r" }, { "sim":50.0, - "partner":"3h7r" + "partner":"6lcn" }, { "sim":50.0, @@ -956665,27 +960827,27 @@ }, { "sim":50.0, - "partner":"5tyq" + "partner":"5u0n" }, { "sim":50.0, - "partner":"5u19" + "partner":"5u1e" }, { "sim":50.0, - "partner":"5u0n" + "partner":"5u0t" }, { "sim":50.0, - "partner":"5u1e" + "partner":"5u1i" }, { "sim":50.0, - "partner":"5u0t" + "partner":"5tyq" }, { "sim":50.0, - "partner":"5u1i" + "partner":"5u19" }, { "sim":50.0, @@ -956779,10 +960941,6 @@ "sim":50.0, "partner":"4ot7" }, - { - "sim":50.0, - "partner":"6put" - }, { "sim":50.0, "partner":"6puw" @@ -956797,15 +960955,15 @@ }, { "sim":50.0, - "partner":"5u1c" + "partner":"6puz" }, { "sim":50.0, - "partner":"6puz" + "partner":"5u1c" }, { "sim":50.0, - "partner":"7azd" + "partner":"6put" }, { "sim":50.0, @@ -956837,16 +960995,20 @@ }, { "sim":50.0, - "partner":"5x06" + "partner":"7azg" }, { "sim":50.0, - "partner":"7azg" + "partner":"5x06" }, { "sim":50.0, "partner":"7azc" }, + { + "sim":50.0, + "partner":"7azd" + }, { "sim":50.0, "partner":"6d5a" @@ -956871,10 +961033,6 @@ "sim":50.0, "partner":"2qdg" }, - { - "sim":50.0, - "partner":"4wwv" - }, { "sim":50.0, "partner":"3vvl" @@ -956895,6 +961053,10 @@ "sim":50.0, "partner":"5zzu" }, + { + "sim":50.0, + "partner":"4wwv" + }, { "sim":50.0, "partner":"5gu7" @@ -956923,10 +961085,6 @@ "sim":50.0, "partner":"4y1b" }, - { - "sim":50.0, - "partner":"5cu7" - }, { "sim":50.0, "partner":"4y0k" @@ -956945,7 +961103,7 @@ }, { "sim":50.0, - "partner":"4f6c" + "partner":"5cu7" }, { "sim":50.0, @@ -956959,21 +961117,25 @@ "sim":50.0, "partner":"6hr8" }, + { + "sim":50.0, + "partner":"4f6c" + }, { "sim":50.0, "partner":"8w6z" }, { "sim":50.0, - "partner":"7d88" + "partner":"8w72" }, { "sim":50.0, - "partner":"7d89" + "partner":"7d88" }, { "sim":50.0, - "partner":"8w72" + "partner":"7d89" }, { "sim":50.0, @@ -956987,10 +961149,6 @@ "sim":50.0, "partner":"7u7h" }, - { - "sim":50.0, - "partner":"2imc" - }, { "sim":50.0, "partner":"2ilp" @@ -957021,15 +961179,19 @@ }, { "sim":50.0, - "partner":"7n18" + "partner":"2imc" }, { "sim":50.0, - "partner":"4kuf" + "partner":"8tx8" }, { "sim":50.0, - "partner":"8tx8" + "partner":"7n18" + }, + { + "sim":50.0, + "partner":"4kuf" }, { "sim":50.0, @@ -957079,10 +961241,6 @@ "sim":50.0, "partner":"4rnh" }, - { - "sim":50.0, - "partner":"7tfc" - }, { "sim":50.0, "partner":"7d4k" @@ -957095,6 +961253,10 @@ "sim":50.0, "partner":"7d4n" }, + { + "sim":50.0, + "partner":"7tfc" + }, { "sim":50.0, "partner":"4j1q" @@ -957103,6 +961265,18 @@ "sim":50.0, "partner":"4j1s" }, + { + "sim":50.0, + "partner":"8wn5" + }, + { + "sim":50.0, + "partner":"8wn6" + }, + { + "sim":50.0, + "partner":"8wna" + }, { "sim":50.0, "partner":"8tge" @@ -957123,10 +961297,6 @@ "sim":50.0, "partner":"8ufj" }, - { - "sim":50.0, - "partner":"2wc4" - }, { "sim":50.0, "partner":"1oif" @@ -957241,11 +961411,11 @@ }, { "sim":50.0, - "partner":"6j0u" + "partner":"2wc4" }, { "sim":50.0, - "partner":"6ak4" + "partner":"6j0u" }, { "sim":50.0, @@ -957267,6 +961437,10 @@ "sim":50.0, "partner":"6llb" }, + { + "sim":50.0, + "partner":"6ak4" + }, { "sim":50.0, "partner":"8u41" @@ -957289,11 +961463,11 @@ }, { "sim":50.0, - "partner":"4dqv" + "partner":"4u5q" }, { "sim":50.0, - "partner":"4u5q" + "partner":"4dqv" }, { "sim":50.0, @@ -957331,10 +961505,6 @@ "sim":50.0, "partner":"6jzs" }, - { - "sim":50.0, - "partner":"4ie7" - }, { "sim":50.0, "partner":"4cxw" @@ -957353,15 +961523,15 @@ }, { "sim":50.0, - "partner":"4idz" + "partner":"7e8z" }, { "sim":50.0, - "partner":"4ie0" + "partner":"4idz" }, { "sim":50.0, - "partner":"7e8z" + "partner":"4ie0" }, { "sim":50.0, @@ -957379,6 +961549,10 @@ "sim":50.0, "partner":"4qho" }, + { + "sim":50.0, + "partner":"4ie7" + }, { "sim":50.0, "partner":"6u4z" @@ -957399,25 +961573,17 @@ "sim":50.0, "partner":"7wh9" }, - { - "sim":50.0, - "partner":"8w04" - }, { "sim":50.0, "partner":"8w01" }, { "sim":50.0, - "partner":"3n6r" - }, - { - "sim":50.0, - "partner":"8aq3" + "partner":"8w04" }, { "sim":50.0, - "partner":"8aq4" + "partner":"3n6r" }, { "sim":50.0, @@ -957427,10 +961593,6 @@ "sim":50.0, "partner":"8b0k" }, - { - "sim":50.0, - "partner":"5n6h" - }, { "sim":50.0, "partner":"8b0l" @@ -957443,6 +961605,10 @@ "sim":50.0, "partner":"8b0n" }, + { + "sim":50.0, + "partner":"5n6h" + }, { "sim":50.0, "partner":"8b0o" @@ -957461,12 +961627,20 @@ }, { "sim":50.0, - "partner":"8j8h" + "partner":"8aq3" + }, + { + "sim":50.0, + "partner":"8aq4" }, { "sim":50.0, "partner":"8j9g" }, + { + "sim":50.0, + "partner":"8j8h" + }, { "sim":50.0, "partner":"7wh1" @@ -957513,7 +961687,7 @@ }, { "sim":50.0, - "partner":"5m12" + "partner":"6gwg" }, { "sim":50.0, @@ -957521,20 +961695,12 @@ }, { "sim":50.0, - "partner":"6gwf" - }, - { - "sim":50.0, - "partner":"6gwg" + "partner":"6gta" }, { "sim":50.0, "partner":"5m16" }, - { - "sim":50.0, - "partner":"6gta" - }, { "sim":50.0, "partner":"6gvd" @@ -957549,11 +961715,15 @@ }, { "sim":50.0, - "partner":"6j1f" + "partner":"5m12" }, { "sim":50.0, - "partner":"6j1e" + "partner":"6gwf" + }, + { + "sim":50.0, + "partner":"6j1f" }, { "sim":50.0, @@ -957571,6 +961741,10 @@ "sim":50.0, "partner":"6j0p" }, + { + "sim":50.0, + "partner":"6j1e" + }, { "sim":50.0, "partner":"3i3l" @@ -957611,10 +961785,6 @@ "sim":50.0, "partner":"3vsn" }, - { - "sim":50.0, - "partner":"7w1c" - }, { "sim":50.0, "partner":"7w1d" @@ -957625,15 +961795,7 @@ }, { "sim":50.0, - "partner":"2yii" - }, - { - "sim":50.0, - "partner":"4c5s" - }, - { - "sim":50.0, - "partner":"4v2r" + "partner":"7w1c" }, { "sim":50.0, @@ -957659,22 +961821,30 @@ "sim":50.0, "partner":"4c5r" }, + { + "sim":50.0, + "partner":"2yii" + }, { "sim":50.0, "partner":"4v2q" }, { "sim":50.0, - "partner":"5uw0" + "partner":"4c5s" }, { "sim":50.0, - "partner":"5vnc" + "partner":"4v2r" }, { "sim":50.0, "partner":"5uw1" }, + { + "sim":50.0, + "partner":"5vnc" + }, { "sim":50.0, "partner":"5uw4" @@ -957685,7 +961855,7 @@ }, { "sim":50.0, - "partner":"3rsz" + "partner":"5uw0" }, { "sim":50.0, @@ -957715,6 +961885,10 @@ "sim":50.0, "partner":"3nch" }, + { + "sim":50.0, + "partner":"3rsz" + }, { "sim":50.0, "partner":"8eax" @@ -957735,10 +961909,6 @@ "sim":50.0, "partner":"2wco" }, - { - "sim":50.0, - "partner":"6edw" - }, { "sim":50.0, "partner":"6edz" @@ -957749,15 +961919,11 @@ }, { "sim":50.0, - "partner":"8bou" - }, - { - "sim":50.0, - "partner":"4j3t" + "partner":"6edw" }, { "sim":50.0, - "partner":"4j3u" + "partner":"8bou" }, { "sim":50.0, @@ -957777,7 +961943,11 @@ }, { "sim":50.0, - "partner":"5y1h" + "partner":"4j3t" + }, + { + "sim":50.0, + "partner":"4j3u" }, { "sim":50.0, @@ -957823,6 +961993,10 @@ "sim":50.0, "partner":"5y3i" }, + { + "sim":50.0, + "partner":"5y1h" + }, { "sim":50.0, "partner":"7s6b" @@ -957841,15 +962015,15 @@ }, { "sim":50.0, - "partner":"7o3m" + "partner":"7o3n" }, { "sim":50.0, - "partner":"7o3n" + "partner":"7o3l" }, { "sim":50.0, - "partner":"7o3l" + "partner":"7o3m" }, { "sim":50.0, @@ -957861,14 +962035,14 @@ "sim":0.9980999827, "partner":"8v0a" }, - { - "sim":0.9674999714, - "partner":"8w05" - }, { "sim":0.9933000207, "partner":"8v2w" }, + { + "sim":0.9674999714, + "partner":"8w05" + }, { "sim":0.9681000113, "partner":"8w06" @@ -957883,14 +962057,18 @@ } ], "struct_thr_sim_natural":[ - { - "sim":0.950699985, - "partner":"5zg5" - }, { "sim":0.9516999722, "partner":"5zfx" }, + { + "sim":0.9526000023, + "partner":"4obt" + }, + { + "sim":0.950699985, + "partner":"5zg5" + }, { "sim":0.9531999826, "partner":"6nxq" @@ -957898,10 +962076,6 @@ { "sim":0.9520999789, "partner":"6nxr" - }, - { - "sim":0.9526000023, - "partner":"4obt" } ], "seq_max_sim_designed":{ @@ -958075,10 +962249,6 @@ "sim":153.0, "partner":"5tt3" }, - { - "sim":153.0, - "partner":"5tv3" - }, { "sim":153.0, "partner":"4ygf" @@ -958095,6 +962265,10 @@ "sim":153.0, "partner":"5tuo" }, + { + "sim":153.0, + "partner":"5tv3" + }, { "sim":150.0, "partner":"4twl" @@ -958113,7 +962287,7 @@ }, { "sim":146.0, - "partner":"8ttr" + "partner":"8ufw" }, { "sim":146.0, @@ -958133,7 +962307,7 @@ }, { "sim":146.0, - "partner":"8ufw" + "partner":"8ttr" }, { "sim":145.0, @@ -958143,42 +962317,6 @@ "sim":143.0, "partner":"4qk3" }, - { - "sim":143.0, - "partner":"6yzj" - }, - { - "sim":143.0, - "partner":"6yzk" - }, - { - "sim":143.0, - "partner":"6yzl" - }, - { - "sim":143.0, - "partner":"6yj3" - }, - { - "sim":143.0, - "partner":"6yo7" - }, - { - "sim":143.0, - "partner":"6yzm" - }, - { - "sim":143.0, - "partner":"8olf" - }, - { - "sim":143.0, - "partner":"6ykh" - }, - { - "sim":143.0, - "partner":"6yzn" - }, { "sim":143.0, "partner":"6gcy" @@ -958187,18 +962325,10 @@ "sim":143.0, "partner":"6yzo" }, - { - "sim":143.0, - "partner":"8ola" - }, { "sim":143.0, "partner":"6yzp" }, - { - "sim":143.0, - "partner":"8okj" - }, { "sim":143.0, "partner":"6fji" @@ -958233,11 +962363,11 @@ }, { "sim":143.0, - "partner":"4zao" + "partner":"7jo2" }, { "sim":143.0, - "partner":"7jo2" + "partner":"4zao" }, { "sim":143.0, @@ -958245,47 +962375,43 @@ }, { "sim":143.0, - "partner":"8oko" + "partner":"8olf" }, { "sim":143.0, - "partner":"8oke" + "partner":"8ola" }, { "sim":143.0, - "partner":"8okp" + "partner":"8okj" }, { "sim":143.0, "partner":"4riu" }, - { - "sim":143.0, - "partner":"8okg" - }, { "sim":143.0, "partner":"4riv" }, { "sim":143.0, - "partner":"4r59" + "partner":"6yo2" }, { "sim":143.0, - "partner":"4r5a" + "partner":"4r59" }, { "sim":143.0, - "partner":"6yo2" + "partner":"6ql1" }, { "sim":143.0, - "partner":"6ql1" + "partner":"6rzx" }, { "sim":143.0, - "partner":"6rzx" + "partner":"4r5a" }, { "sim":143.0, @@ -958307,18 +962433,30 @@ "sim":143.0, "partner":"6yoi" }, + { + "sim":143.0, + "partner":"8oko" + }, { "sim":143.0, "partner":"6yo4" }, { "sim":143.0, - "partner":"7k6x" + "partner":"8oke" + }, + { + "sim":143.0, + "partner":"8okp" }, { "sim":143.0, "partner":"6yok" }, + { + "sim":143.0, + "partner":"7k6x" + }, { "sim":143.0, "partner":"6ykc" @@ -958331,10 +962469,46 @@ "sim":143.0, "partner":"6z04" }, + { + "sim":143.0, + "partner":"8okg" + }, { "sim":143.0, "partner":"7k6z" }, + { + "sim":143.0, + "partner":"6yzj" + }, + { + "sim":143.0, + "partner":"6yzk" + }, + { + "sim":143.0, + "partner":"6yzl" + }, + { + "sim":143.0, + "partner":"6yj3" + }, + { + "sim":143.0, + "partner":"6yo7" + }, + { + "sim":143.0, + "partner":"6yzm" + }, + { + "sim":143.0, + "partner":"6ykh" + }, + { + "sim":143.0, + "partner":"6yzn" + }, { "sim":143.0, "partner":"6nj3" @@ -958349,67 +962523,75 @@ }, { "sim":142.0, - "partner":"6yh4" + "partner":"6t7u" }, { "sim":142.0, - "partner":"6yh5" + "partner":"6yh9" }, { "sim":142.0, - "partner":"6yh6" + "partner":"6yha" }, { "sim":142.0, - "partner":"6yh7" + "partner":"4q08" }, { "sim":142.0, - "partner":"6yh8" + "partner":"6yhb" }, { "sim":142.0, - "partner":"4q08" + "partner":"8quf" }, { "sim":142.0, - "partner":"6t7u" + "partner":"4q09" }, { "sim":142.0, - "partner":"6yh9" + "partner":"6yhc" }, { "sim":142.0, - "partner":"4q09" + "partner":"8rlq" }, { "sim":142.0, - "partner":"6yha" + "partner":"5g01" }, { "sim":142.0, - "partner":"6yhb" + "partner":"8okt" }, { "sim":142.0, - "partner":"6yhc" + "partner":"5g0c" }, { "sim":142.0, - "partner":"8okt" + "partner":"6yh4" }, { "sim":142.0, - "partner":"8quf" + "partner":"6yh5" }, { "sim":142.0, - "partner":"5g01" + "partner":"6yh6" }, { "sim":142.0, - "partner":"5g0c" + "partner":"8rns" + }, + { + "sim":142.0, + "partner":"6yh7" + }, + { + "sim":142.0, + "partner":"6yh8" }, { "sim":142.0, @@ -958431,10 +962613,6 @@ "sim":141.0, "partner":"4k0z" }, - { - "sim":141.0, - "partner":"3ryy" - }, { "sim":141.0, "partner":"3ryv" @@ -958447,6 +962625,10 @@ "sim":141.0, "partner":"5ogp" }, + { + "sim":141.0, + "partner":"3ryy" + }, { "sim":141.0, "partner":"1jv0" @@ -958469,35 +962651,35 @@ }, { "sim":140.0, - "partner":"6nlv" + "partner":"6b5a" }, { "sim":140.0, - "partner":"6b5a" + "partner":"6eeh" }, { "sim":140.0, - "partner":"6ugz" + "partner":"6e8p" }, { "sim":140.0, - "partner":"6eeh" + "partner":"6e8x" }, { "sim":140.0, - "partner":"7rrf" + "partner":"6gxb" }, { "sim":140.0, - "partner":"6e8p" + "partner":"7rrf" }, { "sim":140.0, - "partner":"6e8x" + "partner":"6oum" }, { "sim":140.0, - "partner":"6gxb" + "partner":"6ugo" }, { "sim":140.0, @@ -958509,31 +962691,31 @@ }, { "sim":140.0, - "partner":"6oum" + "partner":"6eea" }, { "sim":140.0, - "partner":"5sz4" + "partner":"6gxe" }, { "sim":140.0, - "partner":"6ugo" + "partner":"7suw" }, { "sim":140.0, - "partner":"7suw" + "partner":"5sz4" }, { "sim":140.0, - "partner":"5sz5" + "partner":"6ugq" }, { "sim":140.0, - "partner":"6eea" + "partner":"5sz5" }, { "sim":140.0, - "partner":"6gxe" + "partner":"7suy" }, { "sim":140.0, @@ -958545,11 +962727,7 @@ }, { "sim":140.0, - "partner":"6ugq" - }, - { - "sim":140.0, - "partner":"7suy" + "partner":"6uzu" }, { "sim":140.0, @@ -958561,19 +962739,19 @@ }, { "sim":140.0, - "partner":"4zwz" + "partner":"6e91" }, { "sim":140.0, - "partner":"6uzu" + "partner":"6u4t" }, { "sim":140.0, - "partner":"6e91" + "partner":"4zwz" }, { "sim":140.0, - "partner":"6u4t" + "partner":"6e92" }, { "sim":140.0, @@ -958581,15 +962759,11 @@ }, { "sim":140.0, - "partner":"4m2w" - }, - { - "sim":140.0, - "partner":"6e92" + "partner":"6oud" }, { "sim":140.0, - "partner":"6oud" + "partner":"4m2w" }, { "sim":140.0, @@ -958607,17 +962781,13 @@ "sim":140.0, "partner":"6otk" }, - { - "sim":140.0, - "partner":"6otm" - }, { "sim":140.0, "partner":"8fr1" }, { "sim":140.0, - "partner":"5jmz" + "partner":"6otm" }, { "sim":140.0, @@ -958629,19 +962799,19 @@ }, { "sim":140.0, - "partner":"6cjv" + "partner":"5jmz" }, { "sim":140.0, - "partner":"7sv8" + "partner":"6cjv" }, { "sim":140.0, - "partner":"5jn3" + "partner":"8fr4" }, { "sim":140.0, - "partner":"8fr4" + "partner":"7sv8" }, { "sim":140.0, @@ -958649,36 +962819,40 @@ }, { "sim":140.0, - "partner":"4ygj" + "partner":"5jn3" }, { "sim":140.0, - "partner":"4ygk" + "partner":"6nlv" }, { "sim":140.0, - "partner":"4ygl" + "partner":"6ugz" }, { "sim":140.0, - "partner":"4ygn" + "partner":"4ygj" }, { "sim":140.0, - "partner":"8s4f" + "partner":"4ygk" }, { "sim":140.0, - "partner":"8vzg" + "partner":"4ygl" }, { "sim":140.0, - "partner":"4wr7" + "partner":"4ygn" }, { "sim":140.0, "partner":"4q06" }, + { + "sim":140.0, + "partner":"4wr7" + }, { "sim":140.0, "partner":"4q07" @@ -958713,27 +962887,27 @@ }, { "sim":140.0, - "partner":"8rbp" + "partner":"8vzg" }, { "sim":140.0, - "partner":"7q0c" + "partner":"8rbp" }, { "sim":140.0, - "partner":"8rar" + "partner":"8s4f" }, { "sim":140.0, - "partner":"1v9i" + "partner":"7q0c" }, { "sim":140.0, - "partner":"6h38" + "partner":"8rar" }, { "sim":140.0, - "partner":"6sdt" + "partner":"1v9i" }, { "sim":140.0, @@ -958753,16 +962927,24 @@ }, { "sim":140.0, - "partner":"8q3u" + "partner":"6h36" }, { "sim":140.0, - "partner":"6h36" + "partner":"8q3u" }, { "sim":140.0, "partner":"6h37" }, + { + "sim":140.0, + "partner":"6h38" + }, + { + "sim":140.0, + "partner":"6sdt" + }, { "sim":139.0, "partner":"4k0s" @@ -958779,10 +962961,6 @@ "sim":139.0, "partner":"1ugf" }, - { - "sim":139.0, - "partner":"1v9e" - }, { "sim":139.0, "partner":"2pov" @@ -958793,7 +962971,7 @@ }, { "sim":139.0, - "partner":"3dc9" + "partner":"1v9e" }, { "sim":139.0, @@ -958821,7 +962999,7 @@ }, { "sim":139.0, - "partner":"1crm" + "partner":"7nzs" }, { "sim":139.0, @@ -958831,29 +963009,25 @@ "sim":139.0, "partner":"3w6i" }, - { - "sim":139.0, - "partner":"7nzs" - }, { "sim":139.0, "partner":"7nzt" }, { "sim":139.0, - "partner":"1hug" + "partner":"7nzu" }, { "sim":139.0, - "partner":"7nzu" + "partner":"6sks" }, { "sim":139.0, - "partner":"1bzm" + "partner":"1crm" }, { "sim":139.0, - "partner":"1huh" + "partner":"6skt" }, { "sim":139.0, @@ -958869,35 +963043,31 @@ }, { "sim":139.0, - "partner":"6sks" - }, - { - "sim":139.0, - "partner":"3dcs" + "partner":"7nzw" }, { "sim":139.0, - "partner":"6skt" + "partner":"1hug" }, { "sim":139.0, - "partner":"7nzw" + "partner":"3dcs" }, { "sim":139.0, - "partner":"3lxe" + "partner":"7nzx" }, { "sim":139.0, - "partner":"7nzx" + "partner":"1bzm" }, { "sim":139.0, - "partner":"1czm" + "partner":"1huh" }, { "sim":139.0, - "partner":"1hcb" + "partner":"3lxe" }, { "sim":139.0, @@ -958917,12 +963087,20 @@ }, { "sim":139.0, - "partner":"1azm" + "partner":"1czm" + }, + { + "sim":139.0, + "partner":"1hcb" }, { "sim":139.0, "partner":"3dcw" }, + { + "sim":139.0, + "partner":"1azm" + }, { "sim":139.0, "partner":"3dc3" @@ -958949,31 +963127,15 @@ }, { "sim":139.0, - "partner":"8cdx" - }, - { - "sim":139.0, - "partner":"8q6l" - }, - { - "sim":139.0, - "partner":"6hwz" - }, - { - "sim":139.0, - "partner":"6xzx" - }, - { - "sim":139.0, - "partner":"8cdz" + "partner":"3dc9" }, { "sim":139.0, - "partner":"8qq9" + "partner":"6f3b" }, { "sim":139.0, - "partner":"6f3b" + "partner":"6i0j" }, { "sim":139.0, @@ -958983,10 +963145,6 @@ "sim":139.0, "partner":"6xzy" }, - { - "sim":139.0, - "partner":"6i0j" - }, { "sim":139.0, "partner":"6i0l" @@ -959001,23 +963159,27 @@ }, { "sim":139.0, - "partner":"7zl5" + "partner":"8rlo" }, { "sim":139.0, "partner":"6swm" }, + { + "sim":139.0, + "partner":"7zl5" + }, { "sim":139.0, "partner":"6g3v" }, { "sim":139.0, - "partner":"6ex1" + "partner":"8qun" }, { "sim":139.0, - "partner":"8q7g" + "partner":"6ex1" }, { "sim":139.0, @@ -959029,19 +963191,19 @@ }, { "sim":139.0, - "partner":"8qun" + "partner":"8q7g" }, { "sim":139.0, - "partner":"5gmm" + "partner":"6fag" }, { "sim":139.0, - "partner":"6fag" + "partner":"6xzs" }, { "sim":139.0, - "partner":"6xzs" + "partner":"5gmm" }, { "sim":139.0, @@ -959049,44 +963211,48 @@ }, { "sim":139.0, - "partner":"6xzo" + "partner":"8qq9" }, { "sim":139.0, - "partner":"7q0d" + "partner":"6xzo" }, { "sim":139.0, - "partner":"4cnr" + "partner":"8cdx" }, { "sim":139.0, - "partner":"6rm1" + "partner":"7q0d" }, { "sim":139.0, - "partner":"6sfu" + "partner":"6hwz" }, { "sim":139.0, - "partner":"6roe" + "partner":"8cdz" }, { "sim":139.0, - "partner":"5m78" + "partner":"6xzx" }, { "sim":139.0, - "partner":"6gdc" + "partner":"8q6l" }, { "sim":139.0, - "partner":"3m1k" + "partner":"4cnr" }, { "sim":139.0, "partner":"6rs5" }, + { + "sim":139.0, + "partner":"3m1k" + }, { "sim":139.0, "partner":"6hxd" @@ -959097,23 +963263,23 @@ }, { "sim":139.0, - "partner":"3m14" + "partner":"6hr3" }, { "sim":139.0, - "partner":"3m04" + "partner":"6sac" }, { "sim":139.0, - "partner":"6hr3" + "partner":"6sbh" }, { "sim":139.0, - "partner":"6sac" + "partner":"3m14" }, { "sim":139.0, - "partner":"6sbh" + "partner":"3m04" }, { "sim":139.0, @@ -959133,15 +963299,15 @@ }, { "sim":139.0, - "partner":"6rg5" + "partner":"8r1i" }, { "sim":139.0, - "partner":"6rmp" + "partner":"6rg5" }, { "sim":139.0, - "partner":"8r1i" + "partner":"6rmp" }, { "sim":139.0, @@ -959197,35 +963363,35 @@ }, { "sim":139.0, - "partner":"3m2x" + "partner":"6sdl" }, { "sim":139.0, - "partner":"5ll8" + "partner":"6hqx" }, { "sim":139.0, - "partner":"6sdl" + "partner":"6i0w" }, { "sim":139.0, - "partner":"3m2y" + "partner":"6rjj" }, { "sim":139.0, - "partner":"6hqx" + "partner":"3m2x" }, { "sim":139.0, - "partner":"6i0w" + "partner":"5ll8" }, { "sim":139.0, - "partner":"6rjj" + "partner":"6say" }, { "sim":139.0, - "partner":"6say" + "partner":"3m2y" }, { "sim":139.0, @@ -959277,47 +963443,35 @@ }, { "sim":139.0, - "partner":"5zxw" + "partner":"6rm1" }, { "sim":139.0, - "partner":"3ml5" + "partner":"6sfu" }, { "sim":139.0, - "partner":"3mdz" - }, - { - "sim":138.0, - "partner":"4mdm" - }, - { - "sim":138.0, - "partner":"5ljq" - }, - { - "sim":138.0, - "partner":"7a6v" + "partner":"6roe" }, { - "sim":138.0, - "partner":"7q0e" + "sim":139.0, + "partner":"6gdc" }, { - "sim":138.0, - "partner":"5ljt" + "sim":139.0, + "partner":"5m78" }, { - "sim":138.0, - "partner":"5nxo" + "sim":139.0, + "partner":"5zxw" }, { - "sim":138.0, - "partner":"1ugd" + "sim":139.0, + "partner":"3ml5" }, { - "sim":138.0, - "partner":"5nxp" + "sim":139.0, + "partner":"3mdz" }, { "sim":138.0, @@ -959379,6 +963533,10 @@ "sim":138.0, "partner":"4z0q" }, + { + "sim":138.0, + "partner":"6vj3" + }, { "sim":138.0, "partner":"3rj7" @@ -959389,11 +963547,11 @@ }, { "sim":138.0, - "partner":"6vj3" + "partner":"4mdg" }, { "sim":138.0, - "partner":"4mdg" + "partner":"8q0c" }, { "sim":138.0, @@ -959413,35 +963571,35 @@ }, { "sim":138.0, - "partner":"8phl" + "partner":"5e2s" }, { "sim":138.0, - "partner":"8p6u" + "partner":"5jdv" }, { "sim":138.0, - "partner":"5e2s" + "partner":"7m23" }, { "sim":138.0, - "partner":"8q0c" + "partner":"7m24" }, { "sim":138.0, - "partner":"5jdv" + "partner":"5ny3" }, { "sim":138.0, - "partner":"7m23" + "partner":"8b29" }, { "sim":138.0, - "partner":"5ny3" + "partner":"7m26" }, { "sim":138.0, - "partner":"7m24" + "partner":"8phl" }, { "sim":138.0, @@ -959449,7 +963607,7 @@ }, { "sim":138.0, - "partner":"7m26" + "partner":"7a6v" }, { "sim":138.0, @@ -959457,7 +963615,7 @@ }, { "sim":138.0, - "partner":"8b29" + "partner":"8p6u" }, { "sim":138.0, @@ -959469,147 +963627,139 @@ }, { "sim":138.0, - "partner":"1bnt" - }, - { - "sim":138.0, - "partner":"1g4o" - }, - { - "sim":138.0, - "partner":"1if5" + "partner":"7q0e" }, { "sim":138.0, - "partner":"1rze" + "partner":"4mdm" }, { "sim":138.0, - "partner":"1zfk" + "partner":"5ljq" }, { "sim":138.0, - "partner":"1bnu" + "partner":"5ljt" }, { "sim":138.0, - "partner":"1if6" + "partner":"5nxo" }, { "sim":138.0, - "partner":"2hd6" + "partner":"1ugd" }, { "sim":138.0, - "partner":"2hl4" + "partner":"5nxp" }, { "sim":138.0, - "partner":"2qo8" + "partner":"1bnt" }, { "sim":138.0, - "partner":"3ryx" + "partner":"1g4o" }, { "sim":138.0, - "partner":"1bnv" + "partner":"1if5" }, { "sim":138.0, - "partner":"1f2w" + "partner":"2ca2" }, { "sim":138.0, - "partner":"1if7" + "partner":"2osf" }, { "sim":138.0, - "partner":"1lug" + "partner":"2qoa" }, { "sim":138.0, - "partner":"2qp6" + "partner":"3ryz" }, { "sim":138.0, - "partner":"1bnw" + "partner":"4fl7" }, { "sim":138.0, - "partner":"1bv3" + "partner":"1bnu" }, { "sim":138.0, - "partner":"1if8" + "partner":"1if6" }, { "sim":138.0, - "partner":"2ca2" + "partner":"3rz0" }, { "sim":138.0, - "partner":"2osf" + "partner":"3v7x" }, { "sim":138.0, - "partner":"2qoa" + "partner":"1bnv" }, { "sim":138.0, - "partner":"3ryz" + "partner":"1f2w" }, { "sim":138.0, - "partner":"4fl7" + "partner":"1if7" }, { "sim":138.0, - "partner":"7ntb" + "partner":"1ze8" }, { "sim":138.0, - "partner":"1if9" + "partner":"3rz1" }, { "sim":138.0, - "partner":"3rz0" + "partner":"5jeg" }, { "sim":138.0, - "partner":"3v7x" + "partner":"1bnw" }, { "sim":138.0, - "partner":"1avn" + "partner":"1bv3" }, { "sim":138.0, - "partner":"1ze8" + "partner":"1if8" }, { "sim":138.0, - "partner":"3rz1" + "partner":"1oq5" }, { "sim":138.0, - "partner":"5jeg" + "partner":"3t5u" }, { "sim":138.0, - "partner":"1oq5" + "partner":"4bf1" }, { "sim":138.0, - "partner":"3t5u" + "partner":"1if9" }, { "sim":138.0, - "partner":"4bf1" + "partner":"2x7s" }, { "sim":138.0, - "partner":"2x7s" + "partner":"1avn" }, { "sim":138.0, @@ -959641,7 +963791,7 @@ }, { "sim":138.0, - "partner":"1cay" + "partner":"6h6s" }, { "sim":138.0, @@ -959653,15 +963803,15 @@ }, { "sim":138.0, - "partner":"1zfq" + "partner":"6q3o" }, { "sim":138.0, - "partner":"4cac" + "partner":"1zfq" }, { "sim":138.0, - "partner":"6h6s" + "partner":"4cac" }, { "sim":138.0, @@ -959669,19 +963819,19 @@ }, { "sim":138.0, - "partner":"6q3o" + "partner":"6q9t" }, { "sim":138.0, - "partner":"2osm" + "partner":"1cay" }, { "sim":138.0, - "partner":"5cac" + "partner":"2osm" }, { "sim":138.0, - "partner":"1g1d" + "partner":"5cac" }, { "sim":138.0, @@ -959695,14 +963845,6 @@ "sim":138.0, "partner":"4yvy" }, - { - "sim":138.0, - "partner":"6q9t" - }, - { - "sim":138.0, - "partner":"1a42" - }, { "sim":138.0, "partner":"2hoc" @@ -959717,11 +963859,7 @@ }, { "sim":138.0, - "partner":"1bn1" - }, - { - "sim":138.0, - "partner":"1i9l" + "partner":"1g1d" }, { "sim":138.0, @@ -959733,11 +963871,7 @@ }, { "sim":138.0, - "partner":"1bn3" - }, - { - "sim":138.0, - "partner":"1i9m" + "partner":"1a42" }, { "sim":138.0, @@ -959755,33 +963889,17 @@ "sim":138.0, "partner":"5nxi" }, - { - "sim":138.0, - "partner":"8oo8" - }, - { - "sim":138.0, - "partner":"1bn4" - }, - { - "sim":138.0, - "partner":"1i9n" - }, { "sim":138.0, "partner":"1xq0" }, { "sim":138.0, - "partner":"1bcd" - }, - { - "sim":138.0, - "partner":"1ca2" + "partner":"1bn1" }, { "sim":138.0, - "partner":"1i9o" + "partner":"1i9l" }, { "sim":138.0, @@ -959797,11 +963915,11 @@ }, { "sim":138.0, - "partner":"1cah" + "partner":"1bn3" }, { "sim":138.0, - "partner":"1i9p" + "partner":"1i9m" }, { "sim":138.0, @@ -959817,11 +963935,11 @@ }, { "sim":138.0, - "partner":"1g52" + "partner":"1bn4" }, { "sim":138.0, - "partner":"1i9q" + "partner":"1i9n" }, { "sim":138.0, @@ -959833,15 +963951,15 @@ }, { "sim":138.0, - "partner":"1bnm" + "partner":"1bcd" }, { "sim":138.0, - "partner":"1g3z" + "partner":"1ca2" }, { "sim":138.0, - "partner":"1g53" + "partner":"1i9o" }, { "sim":138.0, @@ -959853,19 +963971,23 @@ }, { "sim":138.0, - "partner":"1bnn" + "partner":"6ceh" }, { "sim":138.0, - "partner":"1cil" + "partner":"1cah" }, { "sim":138.0, - "partner":"1g54" + "partner":"1i9p" }, { "sim":138.0, - "partner":"1cim" + "partner":"1g52" + }, + { + "sim":138.0, + "partner":"1i9q" }, { "sim":138.0, @@ -959881,47 +964003,47 @@ }, { "sim":138.0, - "partner":"6ceh" + "partner":"1bnm" }, { "sim":138.0, - "partner":"1cin" + "partner":"1g3z" }, { "sim":138.0, - "partner":"1g4j" + "partner":"1g53" }, { "sim":138.0, - "partner":"1bnq" + "partner":"1bnn" }, { "sim":138.0, - "partner":"1g45" + "partner":"1cil" }, { "sim":138.0, - "partner":"3ca2" + "partner":"1g54" }, { "sim":138.0, - "partner":"3gz0" + "partner":"3ca2" }, { "sim":138.0, - "partner":"3po6" + "partner":"3gz0" }, { "sim":138.0, - "partner":"1am6" + "partner":"3po6" }, { "sim":138.0, - "partner":"1g46" + "partner":"8oo8" }, { "sim":138.0, - "partner":"1i8z" + "partner":"1cim" }, { "sim":138.0, @@ -959941,7 +964063,11 @@ }, { "sim":138.0, - "partner":"1i90" + "partner":"1cin" + }, + { + "sim":138.0, + "partner":"1g4j" }, { "sim":138.0, @@ -959965,11 +964091,11 @@ }, { "sim":138.0, - "partner":"1g48" + "partner":"1bnq" }, { "sim":138.0, - "partner":"1i91" + "partner":"1g45" }, { "sim":138.0, @@ -959989,176 +964115,88 @@ }, { "sim":138.0, - "partner":"1if4" - }, - { - "sim":138.0, - "partner":"1rzd" - }, - { - "sim":138.0, - "partner":"1zgf" - }, - { - "sim":138.0, - "partner":"2ili" - }, - { - "sim":138.0, - "partner":"1teq" - }, - { - "sim":138.0, - "partner":"2fov" - }, - { - "sim":138.0, - "partner":"2hkk" - }, - { - "sim":138.0, - "partner":"3bl1" - }, - { - "sim":138.0, - "partner":"3qyk" - }, - { - "sim":138.0, - "partner":"5dsk" - }, - { - "sim":138.0, - "partner":"6luw" - }, - { - "sim":138.0, - "partner":"7oyo" - }, - { - "sim":138.0, - "partner":"7qsi" - }, - { - "sim":138.0, - "partner":"8fal" + "partner":"1am6" }, { "sim":138.0, - "partner":"8fau" + "partner":"1g46" }, { "sim":138.0, - "partner":"3mmf" + "partner":"1i8z" }, { "sim":138.0, - "partner":"3myq" + "partner":"1rzd" }, { "sim":138.0, - "partner":"4fvn" + "partner":"1zgf" }, { "sim":138.0, - "partner":"4mlt" + "partner":"2ili" }, { "sim":138.0, - "partner":"4yxu" + "partner":"1i90" }, { "sim":138.0, - "partner":"5dsl" + "partner":"1rze" }, { "sim":138.0, - "partner":"6lux" + "partner":"1zfk" }, { "sim":138.0, - "partner":"7agn" + "partner":"1g48" }, { "sim":138.0, - "partner":"7asj" + "partner":"1i91" }, { "sim":138.0, - "partner":"7onp" + "partner":"2hd6" }, { "sim":138.0, - "partner":"7oyp" + "partner":"2hl4" }, { "sim":138.0, - "partner":"8aae" + "partner":"2qo8" }, { "sim":138.0, - "partner":"3k2f" + "partner":"3ryx" }, { "sim":138.0, - "partner":"3p5a" + "partner":"1if4" }, { "sim":138.0, - "partner":"3u3a" + "partner":"1lug" }, { "sim":138.0, - "partner":"4fvo" + "partner":"2qp6" }, { "sim":138.0, - "partner":"4mty" + "partner":"7ntb" }, { "sim":138.0, - "partner":"4q81" + "partner":"3f4x" }, { "sim":138.0, "partner":"4qiy" }, - { - "sim":138.0, - "partner":"4yx4" - }, - { - "sim":138.0, - "partner":"5dsm" - }, - { - "sim":138.0, - "partner":"6bc9" - }, - { - "sim":138.0, - "partner":"6h3q" - }, - { - "sim":138.0, - "partner":"6luy" - }, - { - "sim":138.0, - "partner":"6odz" - }, - { - "sim":138.0, - "partner":"7onq" - }, - { - "sim":138.0, - "partner":"7oyq" - }, - { - "sim":138.0, - "partner":"3f4x" - }, { "sim":138.0, "partner":"4rn4" @@ -960173,27 +964211,27 @@ }, { "sim":138.0, - "partner":"6luz" + "partner":"6g3q" }, { "sim":138.0, - "partner":"6oe0" + "partner":"6r6f" }, { "sim":138.0, - "partner":"6sds" + "partner":"6ufd" }, { "sim":138.0, - "partner":"6ufb" + "partner":"7orq" }, { "sim":138.0, - "partner":"7orp" + "partner":"7y2a" }, { "sim":138.0, - "partner":"8aa6" + "partner":"8omp" }, { "sim":138.0, @@ -960229,23 +964267,35 @@ }, { "sim":138.0, - "partner":"6oe1" + "partner":"6lv1" }, { "sim":138.0, - "partner":"6ufc" + "partner":"7jnv" }, { "sim":138.0, - "partner":"7orq" + "partner":"7oyr" }, { "sim":138.0, - "partner":"7y2a" + "partner":"7rre" }, { "sim":138.0, - "partner":"8rj2" + "partner":"7ywt" + }, + { + "sim":138.0, + "partner":"7zwb" + }, + { + "sim":138.0, + "partner":"8c0r" + }, + { + "sim":138.0, + "partner":"8emu" }, { "sim":138.0, @@ -960309,43 +964359,23 @@ }, { "sim":138.0, - "partner":"6g3q" - }, - { - "sim":138.0, - "partner":"6r6f" - }, - { - "sim":138.0, - "partner":"6ufd" - }, - { - "sim":138.0, - "partner":"7jnv" - }, - { - "sim":138.0, - "partner":"7oyr" - }, - { - "sim":138.0, - "partner":"7rre" + "partner":"6lv2" }, { "sim":138.0, - "partner":"7ywt" + "partner":"6t5c" }, { "sim":138.0, - "partner":"7zwb" + "partner":"6yzq" }, { "sim":138.0, - "partner":"8qqa" + "partner":"7jnw" }, { "sim":138.0, - "partner":"1g6v" + "partner":"7y2c" }, { "sim":138.0, @@ -960373,15 +964403,23 @@ }, { "sim":138.0, - "partner":"6lv1" + "partner":"6lv3" }, { "sim":138.0, - "partner":"7jnw" + "partner":"6wka" }, { "sim":138.0, - "partner":"7y2c" + "partner":"6yzr" + }, + { + "sim":138.0, + "partner":"7jnx" + }, + { + "sim":138.0, + "partner":"7k6i" }, { "sim":138.0, @@ -960409,31 +964447,39 @@ }, { "sim":138.0, - "partner":"6lv2" + "partner":"6lv4" }, { "sim":138.0, - "partner":"6t5c" + "partner":"6yzs" }, { "sim":138.0, - "partner":"6yzq" + "partner":"7aeq" }, { "sim":138.0, - "partner":"7jnx" + "partner":"7k6j" }, { "sim":138.0, - "partner":"7k6i" + "partner":"7y2e" }, { "sim":138.0, - "partner":"8c0r" + "partner":"8boe" }, { "sim":138.0, - "partner":"8emu" + "partner":"8omb" + }, + { + "sim":138.0, + "partner":"8rou" + }, + { + "sim":138.0, + "partner":"8ufx" }, { "sim":138.0, @@ -960453,27 +964499,39 @@ }, { "sim":138.0, - "partner":"6lv3" + "partner":"6lv5" }, { "sim":138.0, - "partner":"6wka" + "partner":"6yzt" }, { "sim":138.0, - "partner":"6yzr" + "partner":"7jnz" }, { "sim":138.0, - "partner":"7k6j" + "partner":"7k6k" }, { "sim":138.0, - "partner":"7y2e" + "partner":"7qbh" }, { "sim":138.0, - "partner":"1cnw" + "partner":"7y2f" + }, + { + "sim":138.0, + "partner":"8eyl" + }, + { + "sim":138.0, + "partner":"8oub" + }, + { + "sim":138.0, + "partner":"1g6v" }, { "sim":138.0, @@ -960529,31 +964587,35 @@ }, { "sim":138.0, - "partner":"6lv4" + "partner":"6got" }, { "sim":138.0, - "partner":"6yzs" + "partner":"6lv6" }, { "sim":138.0, - "partner":"7jnz" + "partner":"6yzu" }, { "sim":138.0, - "partner":"7k6k" + "partner":"7k6l" }, { "sim":138.0, - "partner":"7qbh" + "partner":"7y2g" }, { "sim":138.0, - "partner":"7y2f" + "partner":"8exc" }, { "sim":138.0, - "partner":"1cnx" + "partner":"8j2o" + }, + { + "sim":138.0, + "partner":"8rlp" }, { "sim":138.0, @@ -960601,35 +964663,23 @@ }, { "sim":138.0, - "partner":"6lv5" - }, - { - "sim":138.0, - "partner":"6yzt" - }, - { - "sim":138.0, - "partner":"7aeq" - }, - { - "sim":138.0, - "partner":"7k6l" + "partner":"6lv7" }, { "sim":138.0, - "partner":"7y2g" + "partner":"6qeb" }, { "sim":138.0, - "partner":"8boe" + "partner":"6yzv" }, { "sim":138.0, - "partner":"8olm" + "partner":"7y2h" }, { "sim":138.0, - "partner":"1cny" + "partner":"8row" }, { "sim":138.0, @@ -960665,31 +964715,35 @@ }, { "sim":138.0, - "partner":"6got" + "partner":"6lv8" }, { "sim":138.0, - "partner":"6lv6" + "partner":"6rg3" }, { "sim":138.0, - "partner":"6yzu" + "partner":"6yma" }, { "sim":138.0, - "partner":"7y2h" + "partner":"6yzw" }, { "sim":138.0, - "partner":"8eyl" + "partner":"7nh6" }, { "sim":138.0, - "partner":"8ogf" + "partner":"7y2i" }, { "sim":138.0, - "partner":"8oli" + "partner":"7zl6" + }, + { + "sim":138.0, + "partner":"1cnw" }, { "sim":138.0, @@ -960725,99 +964779,99 @@ }, { "sim":138.0, - "partner":"6lv7" + "partner":"6hd2" }, { "sim":138.0, - "partner":"6qeb" + "partner":"6klz" }, { "sim":138.0, - "partner":"6yzv" + "partner":"6lv9" }, { "sim":138.0, - "partner":"7nh6" + "partner":"6rg4" }, { "sim":138.0, - "partner":"7y2i" + "partner":"6syb" }, { "sim":138.0, - "partner":"7zl6" + "partner":"6ymb" }, { "sim":138.0, - "partner":"8exc" + "partner":"6yzx" }, { "sim":138.0, - "partner":"3cyu" + "partner":"7aes" }, { "sim":138.0, - "partner":"3d8w" + "partner":"7qrk" }, { "sim":138.0, - "partner":"3d9z" + "partner":"7qzx" }, { "sim":138.0, - "partner":"5fnl" + "partner":"7y2j" }, { "sim":138.0, - "partner":"5u0g" + "partner":"1cnx" }, { "sim":138.0, - "partner":"5uln" + "partner":"3cyu" }, { "sim":138.0, - "partner":"6lv8" + "partner":"3d8w" }, { "sim":138.0, - "partner":"6rg3" + "partner":"3d9z" }, { "sim":138.0, - "partner":"6yma" + "partner":"5fnl" }, { "sim":138.0, - "partner":"6yzw" + "partner":"5u0g" }, { "sim":138.0, - "partner":"7qrk" + "partner":"5uln" }, { "sim":138.0, - "partner":"7qzx" + "partner":"6km0" }, { "sim":138.0, - "partner":"7y2j" + "partner":"6lva" }, { "sim":138.0, - "partner":"8olk" + "partner":"6wq4" }, { "sim":138.0, - "partner":"8omh" + "partner":"7bhh" }, { "sim":138.0, - "partner":"8saf" + "partner":"7y2k" }, { "sim":138.0, - "partner":"1hca" + "partner":"1cny" }, { "sim":138.0, @@ -960833,47 +964887,31 @@ }, { "sim":138.0, - "partner":"6hd2" - }, - { - "sim":138.0, - "partner":"6klz" - }, - { - "sim":138.0, - "partner":"6lv9" - }, - { - "sim":138.0, - "partner":"6rg4" - }, - { - "sim":138.0, - "partner":"6syb" + "partner":"6km1" }, { "sim":138.0, - "partner":"6ymb" + "partner":"6wq5" }, { "sim":138.0, - "partner":"6yzx" + "partner":"7bi5" }, { "sim":138.0, - "partner":"7y2k" + "partner":"7nh8" }, { "sim":138.0, - "partner":"8j2o" + "partner":"7qnv" }, { "sim":138.0, - "partner":"8sag" + "partner":"7y2l" }, { "sim":138.0, - "partner":"8sd1" + "partner":"8bzz" }, { "sim":138.0, @@ -960905,31 +964943,39 @@ }, { "sim":138.0, - "partner":"6km0" + "partner":"6km2" }, { "sim":138.0, - "partner":"6lva" + "partner":"6r6j" }, { "sim":138.0, - "partner":"6wq4" + "partner":"6t4n" }, { "sim":138.0, - "partner":"7aes" + "partner":"7u5w" }, { "sim":138.0, - "partner":"7nh8" + "partner":"7y2m" }, { "sim":138.0, - "partner":"7qnv" + "partner":"8bjx" }, { "sim":138.0, - "partner":"7y2l" + "partner":"8dj9" + }, + { + "sim":138.0, + "partner":"8fqx" + }, + { + "sim":138.0, + "partner":"8rj2" }, { "sim":138.0, @@ -960977,23 +965023,43 @@ }, { "sim":138.0, - "partner":"6km1" + "partner":"6h29" }, { "sim":138.0, - "partner":"6wq5" + "partner":"6km3" }, { "sim":138.0, - "partner":"7bhh" + "partner":"6t4o" }, { "sim":138.0, - "partner":"7u5w" + "partner":"6wq7" }, { "sim":138.0, - "partner":"7y2m" + "partner":"7bfa" + }, + { + "sim":138.0, + "partner":"7u5x" + }, + { + "sim":138.0, + "partner":"7y2n" + }, + { + "sim":138.0, + "partner":"8fqy" + }, + { + "sim":138.0, + "partner":"8saf" + }, + { + "sim":138.0, + "partner":"1hca" }, { "sim":138.0, @@ -961033,35 +965099,43 @@ }, { "sim":138.0, - "partner":"6km2" + "partner":"6g6t" }, { "sim":138.0, - "partner":"6r6j" + "partner":"6km4" }, { "sim":138.0, - "partner":"6t4n" + "partner":"6rhj" }, { "sim":138.0, - "partner":"7bi5" + "partner":"6t4p" }, { "sim":138.0, - "partner":"7u5x" + "partner":"6wq8" }, { "sim":138.0, - "partner":"7y2n" + "partner":"7ok8" }, { "sim":138.0, - "partner":"8bzz" + "partner":"7y2o" }, { "sim":138.0, - "partner":"8okq" + "partner":"8fqz" + }, + { + "sim":138.0, + "partner":"8sag" + }, + { + "sim":138.0, + "partner":"8sd1" }, { "sim":138.0, @@ -961097,39 +965171,23 @@ }, { "sim":138.0, - "partner":"6h29" - }, - { - "sim":138.0, - "partner":"6km3" - }, - { - "sim":138.0, - "partner":"6t4o" - }, - { - "sim":138.0, - "partner":"6wq7" - }, - { - "sim":138.0, - "partner":"7ok8" + "partner":"6km5" }, { "sim":138.0, - "partner":"7y2o" + "partner":"6pdv" }, { "sim":138.0, - "partner":"8bjx" + "partner":"6rhk" }, { "sim":138.0, - "partner":"8dj9" + "partner":"6wq9" }, { "sim":138.0, - "partner":"8fqx" + "partner":"8exg" }, { "sim":138.0, @@ -961153,31 +965211,23 @@ }, { "sim":138.0, - "partner":"6g6t" - }, - { - "sim":138.0, - "partner":"6km4" - }, - { - "sim":138.0, - "partner":"6rhj" + "partner":"6ic2" }, { "sim":138.0, - "partner":"6t4p" + "partner":"6km6" }, { "sim":138.0, - "partner":"6wq8" + "partner":"6qfu" }, { "sim":138.0, - "partner":"7bfa" + "partner":"6t81" }, { "sim":138.0, - "partner":"8fqy" + "partner":"8olm" }, { "sim":138.0, @@ -961209,27 +965259,23 @@ }, { "sim":138.0, - "partner":"6km5" - }, - { - "sim":138.0, - "partner":"6pdv" + "partner":"6qfv" }, { "sim":138.0, - "partner":"6rhk" + "partner":"6sys" }, { "sim":138.0, - "partner":"6wq9" + "partner":"7y2q" }, { "sim":138.0, - "partner":"8fqz" + "partner":"8ogf" }, { "sim":138.0, - "partner":"1ca3" + "partner":"8oli" }, { "sim":138.0, @@ -961261,27 +965307,23 @@ }, { "sim":138.0, - "partner":"6ic2" - }, - { - "sim":138.0, - "partner":"6km6" + "partner":"6d1l" }, { "sim":138.0, - "partner":"6qfu" + "partner":"6qfw" }, { "sim":138.0, - "partner":"6t81" + "partner":"6ypw" }, { "sim":138.0, - "partner":"7y2q" + "partner":"7bg5" }, { "sim":138.0, - "partner":"8exg" + "partner":"7y2r" }, { "sim":138.0, @@ -961329,15 +965371,27 @@ }, { "sim":138.0, - "partner":"6qfv" + "partner":"6d1m" }, { "sim":138.0, - "partner":"6sys" + "partner":"6qfx" }, { "sim":138.0, - "partner":"7y2r" + "partner":"7y2s" + }, + { + "sim":138.0, + "partner":"8em3" + }, + { + "sim":138.0, + "partner":"8olk" + }, + { + "sim":138.0, + "partner":"8omh" }, { "sim":138.0, @@ -961381,31 +965435,23 @@ }, { "sim":138.0, - "partner":"6d1l" - }, - { - "sim":138.0, - "partner":"6qfw" - }, - { - "sim":138.0, - "partner":"6ypw" + "partner":"6hx5" }, { "sim":138.0, - "partner":"7y2s" + "partner":"6xwz" }, { "sim":138.0, - "partner":"8omn" + "partner":"7qse" }, { "sim":138.0, - "partner":"8otp" + "partner":"7y2t" }, { "sim":138.0, - "partner":"1cra" + "partner":"1ca3" }, { "sim":138.0, @@ -961461,27 +965507,23 @@ }, { "sim":138.0, - "partner":"6d1m" - }, - { - "sim":138.0, - "partner":"6qfx" + "partner":"6c7w" }, { "sim":138.0, - "partner":"7bg5" + "partner":"6pea" }, { "sim":138.0, - "partner":"7qse" + "partner":"6ux1" }, { "sim":138.0, - "partner":"7y2t" + "partner":"7y2u" }, { "sim":138.0, - "partner":"8sf1" + "partner":"8r2k" }, { "sim":138.0, @@ -961533,19 +965575,23 @@ }, { "sim":138.0, - "partner":"6hx5" + "partner":"6c7x" }, { "sim":138.0, - "partner":"6xwz" + "partner":"7r1x" }, { "sim":138.0, - "partner":"7y2u" + "partner":"7rny" }, { "sim":138.0, - "partner":"8em3" + "partner":"7y2v" + }, + { + "sim":138.0, + "partner":"8r2f" }, { "sim":138.0, @@ -961609,35 +965655,23 @@ }, { "sim":138.0, - "partner":"6c7w" - }, - { - "sim":138.0, - "partner":"6pea" - }, - { - "sim":138.0, - "partner":"6ux1" - }, - { - "sim":138.0, - "partner":"7r1x" + "partner":"7rnz" }, { "sim":138.0, - "partner":"7rny" + "partner":"7y2w" }, { "sim":138.0, - "partner":"7y2v" + "partner":"8cr0" }, { "sim":138.0, - "partner":"8omp" + "partner":"8okq" }, { "sim":138.0, - "partner":"1can" + "partner":"1cra" }, { "sim":138.0, @@ -961689,27 +965723,19 @@ }, { "sim":138.0, - "partner":"6c7x" - }, - { - "sim":138.0, - "partner":"7rnz" - }, - { - "sim":138.0, - "partner":"7y2w" + "partner":"7jnr" }, { "sim":138.0, - "partner":"8sd6" + "partner":"7oym" }, { "sim":138.0, - "partner":"1cao" + "partner":"7y2x" }, { "sim":138.0, - "partner":"1eou" + "partner":"8sf1" }, { "sim":138.0, @@ -961765,27 +965791,31 @@ }, { "sim":138.0, - "partner":"7jnr" + "partner":"6luu" }, { "sim":138.0, - "partner":"7oym" + "partner":"6oto" }, { "sim":138.0, - "partner":"7y2x" + "partner":"6pgx" }, { "sim":138.0, - "partner":"8r2k" + "partner":"6sx9" }, { "sim":138.0, - "partner":"8sd7" + "partner":"6yqt" }, { "sim":138.0, - "partner":"8ufx" + "partner":"7qgx" + }, + { + "sim":138.0, + "partner":"8qqa" }, { "sim":138.0, @@ -961829,19 +965859,35 @@ }, { "sim":138.0, - "partner":"7qgx" + "partner":"6luv" }, { "sim":138.0, - "partner":"8cr0" + "partner":"6yqu" }, { "sim":138.0, - "partner":"8r2f" + "partner":"7onm" }, { "sim":138.0, - "partner":"8sd8" + "partner":"7oyn" + }, + { + "sim":138.0, + "partner":"7qgy" + }, + { + "sim":138.0, + "partner":"8fal" + }, + { + "sim":138.0, + "partner":"8fau" + }, + { + "sim":138.0, + "partner":"1can" }, { "sim":138.0, @@ -961889,43 +965935,31 @@ }, { "sim":138.0, - "partner":"6luu" - }, - { - "sim":138.0, - "partner":"6oto" - }, - { - "sim":138.0, - "partner":"6pgx" - }, - { - "sim":138.0, - "partner":"6sx9" + "partner":"6luw" }, { "sim":138.0, - "partner":"6yqt" + "partner":"7agn" }, { "sim":138.0, - "partner":"7onm" + "partner":"7asj" }, { "sim":138.0, - "partner":"7oyn" + "partner":"7qgz" }, { "sim":138.0, - "partner":"7qgy" + "partner":"8sd6" }, { "sim":138.0, - "partner":"8omb" + "partner":"1cao" }, { "sim":138.0, - "partner":"8sd9" + "partner":"1eou" }, { "sim":138.0, @@ -961981,43 +966015,199 @@ }, { "sim":138.0, - "partner":"6luv" + "partner":"6lux" }, { "sim":138.0, - "partner":"6yqu" + "partner":"7oyo" }, { "sim":138.0, - "partner":"7qgz" + "partner":"7qsi" }, { "sim":138.0, - "partner":"8oub" + "partner":"8sd7" }, { "sim":138.0, - "partner":"8c0q" + "partner":"1teq" }, { "sim":138.0, - "partner":"7onv" + "partner":"2fov" }, { "sim":138.0, - "partner":"6equ" + "partner":"2hkk" }, { "sim":138.0, - "partner":"8zwv" + "partner":"3bl1" }, { "sim":138.0, - "partner":"6rvf" + "partner":"3qyk" }, { "sim":138.0, - "partner":"6rw1" + "partner":"5dsk" + }, + { + "sim":138.0, + "partner":"6h3q" + }, + { + "sim":138.0, + "partner":"6luy" + }, + { + "sim":138.0, + "partner":"6odz" + }, + { + "sim":138.0, + "partner":"7onp" + }, + { + "sim":138.0, + "partner":"7oyp" + }, + { + "sim":138.0, + "partner":"8aae" + }, + { + "sim":138.0, + "partner":"8omn" + }, + { + "sim":138.0, + "partner":"8otp" + }, + { + "sim":138.0, + "partner":"8sd8" + }, + { + "sim":138.0, + "partner":"3mmf" + }, + { + "sim":138.0, + "partner":"3myq" + }, + { + "sim":138.0, + "partner":"4fvn" + }, + { + "sim":138.0, + "partner":"4mlt" + }, + { + "sim":138.0, + "partner":"4yxu" + }, + { + "sim":138.0, + "partner":"5dsl" + }, + { + "sim":138.0, + "partner":"6luz" + }, + { + "sim":138.0, + "partner":"6oe0" + }, + { + "sim":138.0, + "partner":"6sds" + }, + { + "sim":138.0, + "partner":"6ufb" + }, + { + "sim":138.0, + "partner":"7onq" + }, + { + "sim":138.0, + "partner":"7oyq" + }, + { + "sim":138.0, + "partner":"8sd9" + }, + { + "sim":138.0, + "partner":"3k2f" + }, + { + "sim":138.0, + "partner":"3p5a" + }, + { + "sim":138.0, + "partner":"3u3a" + }, + { + "sim":138.0, + "partner":"4fvo" + }, + { + "sim":138.0, + "partner":"4mty" + }, + { + "sim":138.0, + "partner":"4q81" + }, + { + "sim":138.0, + "partner":"4yx4" + }, + { + "sim":138.0, + "partner":"5dsm" + }, + { + "sim":138.0, + "partner":"6bc9" + }, + { + "sim":138.0, + "partner":"6oe1" + }, + { + "sim":138.0, + "partner":"6ufc" + }, + { + "sim":138.0, + "partner":"7orp" + }, + { + "sim":138.0, + "partner":"8aa6" + }, + { + "sim":138.0, + "partner":"8c0q" + }, + { + "sim":138.0, + "partner":"7onv" + }, + { + "sim":138.0, + "partner":"8zwv" + }, + { + "sim":138.0, + "partner":"6equ" }, { "sim":138.0, @@ -962029,11 +966219,11 @@ }, { "sim":138.0, - "partner":"4cnw" + "partner":"6rvl" }, { "sim":138.0, - "partner":"6rvl" + "partner":"4cnw" }, { "sim":138.0, @@ -962055,10 +966245,6 @@ "sim":138.0, "partner":"5jq0" }, - { - "sim":138.0, - "partner":"5e2r" - }, { "sim":138.0, "partner":"6h2z" @@ -962071,6 +966257,10 @@ "sim":138.0, "partner":"6zr8" }, + { + "sim":138.0, + "partner":"5e2r" + }, { "sim":138.0, "partner":"6xxt" @@ -962081,16 +966271,24 @@ }, { "sim":138.0, - "partner":"5jqt" + "partner":"6h34" }, { "sim":138.0, - "partner":"6h34" + "partner":"5jqt" }, { "sim":138.0, "partner":"5lmd" }, + { + "sim":138.0, + "partner":"6rvf" + }, + { + "sim":138.0, + "partner":"6rw1" + }, { "sim":137.0, "partner":"4xiw" @@ -962109,19 +966307,19 @@ }, { "sim":137.0, - "partner":"1ugb" + "partner":"3tvo" }, { "sim":137.0, - "partner":"1ugc" + "partner":"4idr" }, { "sim":137.0, - "partner":"3tvo" + "partner":"1ugb" }, { "sim":137.0, - "partner":"4idr" + "partner":"1ugc" }, { "sim":137.0, @@ -962133,15 +966331,15 @@ }, { "sim":137.0, - "partner":"1cnh" + "partner":"1zsa" }, { "sim":137.0, - "partner":"1zsa" + "partner":"1zsb" }, { "sim":137.0, - "partner":"1zsb" + "partner":"1cnh" }, { "sim":137.0, @@ -962189,239 +966387,235 @@ }, { "sim":136.0, - "partner":"4itp" - }, - { - "sim":136.0, - "partner":"5wg7" + "partner":"5clu" }, { "sim":136.0, - "partner":"6eda" + "partner":"6ebe" }, { "sim":136.0, - "partner":"6otq" + "partner":"6ecz" }, { "sim":136.0, - "partner":"6ouk" + "partner":"4kuw" }, { "sim":136.0, - "partner":"5jn7" + "partner":"4iwz" }, { "sim":136.0, - "partner":"5nya" + "partner":"4z1k" }, { "sim":136.0, - "partner":"6b59" + "partner":"4g0c" }, { "sim":136.0, - "partner":"5clu" + "partner":"5sz0" }, { "sim":136.0, - "partner":"6uh0" + "partner":"5sz1" }, { "sim":136.0, - "partner":"4kuw" + "partner":"6ugn" }, { "sim":136.0, - "partner":"4iwz" + "partner":"5sz2" }, { "sim":136.0, - "partner":"4z1k" + "partner":"4kuy" }, { "sim":136.0, - "partner":"6ebe" + "partner":"4m2r" }, { "sim":136.0, - "partner":"6ecz" + "partner":"5e2k" }, { "sim":136.0, - "partner":"4g0c" + "partner":"5sz3" }, { "sim":136.0, - "partner":"5sz0" + "partner":"6ugp" }, { "sim":136.0, - "partner":"5sz1" + "partner":"6u4q" }, { "sim":136.0, - "partner":"5sz2" + "partner":"3r16" }, { "sim":136.0, - "partner":"4kuy" + "partner":"6ugr" }, { "sim":136.0, - "partner":"4m2r" + "partner":"3r17" }, { "sim":136.0, - "partner":"5e2k" + "partner":"4kv0" }, { "sim":136.0, - "partner":"5sz3" + "partner":"5je7" }, { "sim":136.0, - "partner":"6ugn" + "partner":"5wlt" }, { "sim":136.0, - "partner":"3r16" + "partner":"4zwy" }, { "sim":136.0, - "partner":"6ugp" + "partner":"5e28" }, { "sim":136.0, - "partner":"3r17" + "partner":"5nxg" }, { "sim":136.0, - "partner":"4kv0" + "partner":"6oub" }, { "sim":136.0, - "partner":"5je7" + "partner":"4m2u" }, { "sim":136.0, - "partner":"5wlt" + "partner":"4zwi" }, { "sim":136.0, - "partner":"6u4q" + "partner":"5eij" }, { "sim":136.0, - "partner":"4zwy" + "partner":"5wlv" }, { "sim":136.0, - "partner":"5e28" + "partner":"6nm0" }, { "sim":136.0, - "partner":"5nxg" + "partner":"4zx0" }, { "sim":136.0, - "partner":"6ugr" + "partner":"8jee" }, { "sim":136.0, - "partner":"4m2u" + "partner":"6hzx" }, { "sim":136.0, - "partner":"4zwi" + "partner":"6mbv" }, { "sim":136.0, - "partner":"5eij" + "partner":"6oue" }, { "sim":136.0, - "partner":"5wlv" + "partner":"8igf" }, { "sim":136.0, - "partner":"4zx0" + "partner":"5bnl" }, { "sim":136.0, - "partner":"6oub" + "partner":"5nxw" }, { "sim":136.0, - "partner":"6nm0" + "partner":"6b4d" }, { "sim":136.0, - "partner":"5bnl" + "partner":"6mby" }, { "sim":136.0, - "partner":"5nxw" + "partner":"5ny1" }, { "sim":136.0, - "partner":"6hzx" + "partner":"5w8b" }, { "sim":136.0, - "partner":"6mbv" + "partner":"6xvh" }, { "sim":136.0, - "partner":"6oue" + "partner":"4ilx" }, { "sim":136.0, - "partner":"6b4d" + "partner":"6ouh" }, { "sim":136.0, - "partner":"8jee" + "partner":"6otp" }, { "sim":136.0, - "partner":"8igf" + "partner":"6ouj" }, { "sim":136.0, - "partner":"5ny1" + "partner":"6eda" }, { "sim":136.0, - "partner":"5w8b" + "partner":"6otq" }, { "sim":136.0, - "partner":"6mby" + "partner":"6ouk" }, { "sim":136.0, - "partner":"4ilx" + "partner":"4itp" }, { "sim":136.0, - "partner":"6xvh" + "partner":"5wg7" }, { "sim":136.0, - "partner":"6ouh" + "partner":"5jn7" }, { "sim":136.0, - "partner":"6otp" + "partner":"5nya" }, { "sim":136.0, - "partner":"6ouj" + "partner":"6b59" }, { "sim":136.0, - "partner":"5jep" + "partner":"6uh0" }, { "sim":136.0, @@ -962429,7 +966623,7 @@ }, { "sim":136.0, - "partner":"1cct" + "partner":"5jep" }, { "sim":136.0, @@ -962439,6 +966633,10 @@ "sim":136.0, "partner":"5jeh" }, + { + "sim":136.0, + "partner":"1cct" + }, { "sim":136.0, "partner":"3dvd" @@ -962449,27 +966647,27 @@ }, { "sim":136.0, - "partner":"1cni" + "partner":"1yda" }, { "sim":136.0, - "partner":"1cnj" + "partner":"1cni" }, { "sim":136.0, - "partner":"1cnk" + "partner":"1ydb" }, { "sim":136.0, - "partner":"1yda" + "partner":"1cnj" }, { "sim":136.0, - "partner":"1ydb" + "partner":"1ydc" }, { "sim":136.0, - "partner":"1ydc" + "partner":"1cnk" }, { "sim":136.0, @@ -962495,10 +966693,6 @@ "sim":136.0, "partner":"1cam" }, - { - "sim":136.0, - "partner":"6rof" - }, { "sim":136.0, "partner":"2nxr" @@ -962517,19 +966711,15 @@ }, { "sim":136.0, - "partner":"1lg5" - }, - { - "sim":136.0, - "partner":"3v3f" + "partner":"8ca2" }, { "sim":136.0, - "partner":"12ca" + "partner":"1lg5" }, { "sim":136.0, - "partner":"1dca" + "partner":"3v3f" }, { "sim":136.0, @@ -962537,11 +966727,7 @@ }, { "sim":136.0, - "partner":"1dcb" - }, - { - "sim":136.0, - "partner":"8ca2" + "partner":"9ca2" }, { "sim":136.0, @@ -962557,19 +966743,19 @@ }, { "sim":136.0, - "partner":"1heb" + "partner":"12ca" }, { "sim":136.0, - "partner":"1hec" + "partner":"1dca" }, { "sim":136.0, - "partner":"4l5u" + "partner":"1dcb" }, { "sim":136.0, - "partner":"1hed" + "partner":"4l5u" }, { "sim":136.0, @@ -962581,11 +966767,15 @@ }, { "sim":136.0, - "partner":"1fql" + "partner":"1heb" }, { "sim":136.0, - "partner":"9ca2" + "partner":"1hec" + }, + { + "sim":136.0, + "partner":"1hed" }, { "sim":136.0, @@ -962595,22 +966785,34 @@ "sim":136.0, "partner":"5ti0" }, + { + "sim":136.0, + "partner":"1fql" + }, { "sim":136.0, "partner":"1tg9" }, + { + "sim":136.0, + "partner":"6ca2" + }, { "sim":136.0, "partner":"1lgd" }, { "sim":136.0, - "partner":"6ca2" + "partner":"6rof" }, { "sim":135.0, "partner":"1mua" }, + { + "sim":135.0, + "partner":"2h4n" + }, { "sim":135.0, "partner":"1ccs" @@ -962621,7 +966823,7 @@ }, { "sim":135.0, - "partner":"2h4n" + "partner":"5jg5" }, { "sim":135.0, @@ -962631,10 +966833,6 @@ "sim":135.0, "partner":"1bic" }, - { - "sim":135.0, - "partner":"5jg5" - }, { "sim":135.0, "partner":"3dv7" @@ -962677,11 +966875,11 @@ }, { "sim":134.0, - "partner":"1h9q" + "partner":"3dvb" }, { "sim":134.0, - "partner":"3dvb" + "partner":"1h9q" }, { "sim":134.0, @@ -962713,23 +966911,23 @@ }, { "sim":134.0, - "partner":"1fr4" + "partner":"4fik" }, { "sim":134.0, - "partner":"1hva" + "partner":"4jsz" }, { "sim":134.0, - "partner":"4fik" + "partner":"1fr4" }, { "sim":134.0, - "partner":"4jsz" + "partner":"4hew" }, { "sim":134.0, - "partner":"4hew" + "partner":"1hva" }, { "sim":134.0, @@ -962741,19 +966939,15 @@ }, { "sim":134.0, - "partner":"1g0e" - }, - { - "sim":134.0, - "partner":"1g0f" + "partner":"7ca2" }, { "sim":134.0, - "partner":"7ca2" + "partner":"1g0e" }, { "sim":134.0, - "partner":"1fqm" + "partner":"1g0f" }, { "sim":134.0, @@ -962765,16 +966959,20 @@ }, { "sim":134.0, - "partner":"1fqn" + "partner":"1moo" }, { "sim":134.0, - "partner":"1moo" + "partner":"1fqm" }, { "sim":134.0, "partner":"4hf3" }, + { + "sim":134.0, + "partner":"1fqn" + }, { "sim":134.0, "partner":"4jss" @@ -962813,11 +967011,11 @@ }, { "sim":133.0, - "partner":"8phm" + "partner":"5jgs" }, { "sim":133.0, - "partner":"5jgs" + "partner":"8phm" }, { "sim":133.0, @@ -962825,11 +967023,11 @@ }, { "sim":133.0, - "partner":"8oge" + "partner":"1fr7" }, { "sim":133.0, - "partner":"1fr7" + "partner":"8oge" }, { "sim":133.0, @@ -962913,11 +967111,11 @@ }, { "sim":129.0, - "partner":"3m1w" + "partner":"3m1q" }, { "sim":129.0, - "partner":"3m1q" + "partner":"3m1w" }, { "sim":129.0, @@ -962937,7 +967135,7 @@ }, { "sim":117.0, - "partner":"5ll5" + "partner":"4ww8" }, { "sim":117.0, @@ -962945,59 +967143,59 @@ }, { "sim":117.0, - "partner":"6g7a" + "partner":"5msa" }, { "sim":117.0, - "partner":"7puv" + "partner":"7puw" }, { "sim":117.0, - "partner":"5msa" + "partner":"5llp" }, { "sim":117.0, - "partner":"6qn0" + "partner":"4kp5" }, { "sim":117.0, - "partner":"4ww8" + "partner":"5msb" }, { "sim":117.0, - "partner":"5llp" + "partner":"6qng" }, { "sim":117.0, - "partner":"7puw" + "partner":"6t5p" }, { "sim":117.0, - "partner":"4kp5" + "partner":"4qjw" }, { "sim":117.0, - "partner":"5msb" + "partner":"6g5l" }, { "sim":117.0, - "partner":"4qjw" + "partner":"4qj0" }, { "sim":117.0, - "partner":"6qng" + "partner":"6t5q" }, { "sim":117.0, - "partner":"6t5p" + "partner":"4q0l" }, { "sim":117.0, - "partner":"4qj0" + "partner":"4kp8" }, { "sim":117.0, - "partner":"6g5l" + "partner":"8co3" }, { "sim":117.0, @@ -963005,55 +967203,55 @@ }, { "sim":117.0, - "partner":"4q0l" + "partner":"1jd0" }, { "sim":117.0, - "partner":"6t5q" + "partner":"6qnl" }, { "sim":117.0, - "partner":"4kp8" + "partner":"7pp9" }, { "sim":117.0, - "partner":"1jd0" + "partner":"4ht2" }, { "sim":117.0, - "partner":"8co3" + "partner":"6r6y" }, { "sim":117.0, - "partner":"6qnl" + "partner":"6r71" }, { "sim":117.0, - "partner":"7pp9" + "partner":"4qjo" }, { "sim":117.0, - "partner":"4ht2" + "partner":"5ll9" }, { "sim":117.0, - "partner":"4qjo" + "partner":"7puu" }, { "sim":117.0, - "partner":"6r6y" + "partner":"6g7a" }, { "sim":117.0, - "partner":"6r71" + "partner":"5ll5" }, { "sim":117.0, - "partner":"5ll9" + "partner":"6qn0" }, { "sim":117.0, - "partner":"7puu" + "partner":"7puv" }, { "sim":116.0, @@ -963145,31 +967343,31 @@ }, { "sim":105.0, - "partner":"7pom" + "partner":"6tl5" }, { "sim":105.0, - "partner":"8co0" + "partner":"8q18" }, { "sim":105.0, - "partner":"8q18" + "partner":"6tl6" }, { "sim":105.0, - "partner":"8q19" + "partner":"8co0" }, { "sim":105.0, - "partner":"8q1a" + "partner":"8q19" }, { "sim":105.0, - "partner":"6tl5" + "partner":"7pom" }, { "sim":105.0, - "partner":"6tl6" + "partner":"8q1a" }, { "sim":105.0, @@ -963213,51 +967411,51 @@ }, { "sim":104.0, - "partner":"3iai" + "partner":"6g9u" }, { "sim":104.0, - "partner":"5fl6" + "partner":"6g98" }, { "sim":104.0, - "partner":"6qn6" + "partner":"6fe0" }, { "sim":104.0, - "partner":"6g9u" + "partner":"6qn2" }, { "sim":104.0, - "partner":"6g98" + "partner":"6fe1" }, { "sim":104.0, - "partner":"6fe0" + "partner":"5fl4" }, { "sim":104.0, - "partner":"6qn2" + "partner":"6fe2" }, { "sim":104.0, - "partner":"5fl4" + "partner":"6qn5" }, { "sim":104.0, - "partner":"6fe1" + "partner":"5fl5" }, { "sim":104.0, - "partner":"5fl5" + "partner":"3iai" }, { "sim":104.0, - "partner":"6fe2" + "partner":"6qn6" }, { "sim":104.0, - "partner":"6qn5" + "partner":"5fl6" }, { "sim":104.0, @@ -963351,10 +967549,6 @@ "sim":99.0, "partner":"7yzh" }, - { - "sim":99.0, - "partner":"7o2s" - }, { "sim":99.0, "partner":"7ng1" @@ -963367,6 +967561,10 @@ "sim":99.0, "partner":"7nex" }, + { + "sim":99.0, + "partner":"7o2s" + }, { "sim":98.0, "partner":"7pri" @@ -963453,8 +967651,8 @@ ], "subtitle":"De novo design protein -pk16", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -963562,8 +967760,8 @@ ], "subtitle":"De novo design binder of hras -120-4", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -963663,8 +967861,8 @@ ], "subtitle":"De novo design protein -t09", "tags":[ - "de novo design protein", - "de novo protein" + "de novo protein", + "de novo design protein" ], "keywords":[ "description", @@ -963786,115 +967984,115 @@ "de novo protein" ], "keywords":[ - "thermal", - "spatial", - "monomeric", - "available", - "glutathione", - "details", - "low", - "hallucinated", - "expressed", - "designed", - "prediction", - "generated", - "uses", "recovery", - "achieves", - "improved", + "demonstrates", + "rate", + "minimum", + "learning", + "hydrophobic", + "key", "methods", - "complete", + "23", + "experimental", + "neighboring", + "core", + "spatial", + "side", + "framework", + "details", + "new", + "residue", + "protein", + "significantly", + "5", + "showed", + "predicting", + "match", + "accurately", + "original", "crystal", + "creating", + "deep", "geometric", - "features", - "sequences", - "altered", - "interactions", + "needed", "conformation", - "similarity", - "designing", - "23", "backbones", - "novel", - "conformations", - "geoseqbuilder", - "5", - "original", - "chain", - "proteins", - "models", - "testing", - "solved", - "redesigned", - "produce", + "soluble", + "step", + "integrates", + "residues", + "specific", "although", + "thermal", + "thioredoxin", + "stability", + "proteins", + "low", + "includes", + "2", + "success", "enzyme", - "https", - "used", - "demonstrates", + "available", + "15", "peroxidase", - "step", - "3", - "match", - "comparable", - "structures", - "includes", - "integrates", - "atomic", - "showed", - "minimum", - "native", - "significantly", + "features", + "bundle", + "proteinmpnn", + "designing", "exhibit", - "first", - "stability", - "framework", - "generation", - "powerful", - "predefined", + "design", + "redesigned", + "atomic", + "chain", + "used", "functional", "explicitly", - "4", - "closely", - "specific", - "activity", - "rate", - "bundle", + "geoseqbuilder", + "produce", + "altered", + "testing", + "tested", + "tool", + "prediction", + "complete", "type", - "predicting", - "design", - "core", - "soluble", + "improved", + "leading", + "glutathione", + "sequence", + "uses", + "solved", + "https", + "designed", + "hallucinated", + "models", + "generation", + "sequences", + "structures", + "expressed", + "first", + "3", + "comparable", + "predefined", + "monomeric", "introduce", - "hydrophobic", + "powerful", + "closely", + "interactions", + "4", "high", - "sequence", - "key", - "learning", - "designs", - "tested", - "proteinmpnn", - "accurately", - "success", - "thioredoxin", - "experimental", - "residues", - "neighboring", - "needed", - "leading", - "creating", + "activity", + "native", + "generated", "cores", - "protein", - "residue", - "15", - "2", - "deep", - "side", - "tool", - "new" + "conformations", + "similarity", + "achieves", + "designs", + "novel" ], "release_date":"2024-10-02", - "publication":"\"All-Atom Protein Sequence Design Based on Geometric Deep Learning\", Angew.Chem.Int.Ed.Engl., e202411461-e202411461", + "publication":"\"All-Atom Protein Sequence Design Based on Geometric Deep Learning\", Angew.Chem.Int.Ed.Engl., 63", "publication_ref":{ "DOI":"10.1002\/anie.202411461", "PubMed":"39295564", @@ -964236,115 +968434,115 @@ "de novo protein" ], "keywords":[ - "thermal", - "spatial", - "monomeric", - "available", - "glutathione", - "details", - "low", - "hallucinated", - "expressed", - "designed", - "prediction", - "generated", - "uses", "recovery", - "achieves", - "improved", + "demonstrates", + "rate", + "minimum", + "learning", + "hydrophobic", + "key", "methods", - "complete", + "23", + "experimental", + "neighboring", + "core", + "spatial", + "side", + "framework", + "details", + "new", + "residue", + "protein", + "significantly", + "5", + "showed", + "predicting", + "match", + "accurately", + "original", "crystal", + "creating", + "deep", "geometric", - "features", - "sequences", - "altered", - "interactions", + "needed", "conformation", - "similarity", - "designing", - "23", "backbones", - "novel", - "conformations", - "geoseqbuilder", - "5", - "original", - "chain", - "proteins", - "models", - "testing", - "solved", - "redesigned", - "produce", + "soluble", + "step", + "integrates", + "residues", + "specific", "although", + "thermal", + "thioredoxin", + "stability", + "proteins", + "low", + "includes", + "2", + "success", "enzyme", - "https", - "used", - "demonstrates", + "available", + "15", "peroxidase", - "step", - "3", - "match", - "comparable", - "structures", - "includes", - "integrates", - "atomic", - "showed", - "minimum", - "native", - "significantly", + "features", + "bundle", + "proteinmpnn", + "designing", "exhibit", - "first", - "stability", - "framework", - "generation", - "powerful", - "predefined", + "design", + "redesigned", + "atomic", + "chain", + "used", "functional", "explicitly", - "4", - "closely", - "specific", - "activity", - "rate", - "bundle", + "geoseqbuilder", + "produce", + "altered", + "testing", + "tested", + "tool", + "prediction", + "complete", "type", - "predicting", - "design", - "core", - "soluble", + "improved", + "leading", + "glutathione", + "sequence", + "uses", + "solved", + "https", + "designed", + "hallucinated", + "models", + "generation", + "sequences", + "structures", + "expressed", + "first", + "3", + "comparable", + "predefined", + "monomeric", "introduce", - "hydrophobic", + "powerful", + "closely", + "interactions", + "4", "high", - "sequence", - "key", - "learning", - "designs", - "tested", - "proteinmpnn", - "accurately", - "success", - "thioredoxin", - "experimental", - "residues", - "neighboring", - "needed", - "leading", - "creating", + "activity", + "native", + "generated", "cores", - "protein", - "residue", - "15", - "2", - "deep", - "side", - "tool", - "new" + "conformations", + "similarity", + "achieves", + "designs", + "novel" ], "release_date":"2024-10-02", - "publication":"\"All-Atom Protein Sequence Design Based on Geometric Deep Learning\", Angew.Chem.Int.Ed.Engl., e202411461-e202411461", + "publication":"\"All-Atom Protein Sequence Design Based on Geometric Deep Learning\", Angew.Chem.Int.Ed.Engl., 63", "publication_ref":{ "DOI":"10.1002\/anie.202411461", "PubMed":"39295564", @@ -964678,115 +968876,115 @@ "de novo protein" ], "keywords":[ - "thermal", - "spatial", - "monomeric", - "available", - "glutathione", - "details", - "low", - "hallucinated", - "expressed", - "designed", - "prediction", - "generated", - "uses", "recovery", - "achieves", - "improved", + "demonstrates", + "rate", + "minimum", + "learning", + "hydrophobic", + "key", "methods", - "complete", + "23", + "experimental", + "neighboring", + "core", + "spatial", + "side", + "framework", + "details", + "new", + "residue", + "protein", + "significantly", + "5", + "showed", + "predicting", + "match", + "accurately", + "original", "crystal", + "creating", + "deep", "geometric", - "features", - "sequences", - "altered", - "interactions", + "needed", "conformation", - "similarity", - "designing", - "23", "backbones", - "novel", - "conformations", - "geoseqbuilder", - "5", - "original", - "chain", - "proteins", - "models", - "testing", - "solved", - "redesigned", - "produce", + "soluble", + "step", + "integrates", + "residues", + "specific", "although", + "thermal", + "thioredoxin", + "stability", + "proteins", + "low", + "includes", + "2", + "success", "enzyme", - "https", - "used", - "demonstrates", + "available", + "15", "peroxidase", - "step", - "3", - "match", - "comparable", - "structures", - "includes", - "integrates", - "atomic", - "showed", - "minimum", - "native", - "significantly", + "features", + "bundle", + "proteinmpnn", + "designing", "exhibit", - "first", - "stability", - "framework", - "generation", - "powerful", - "predefined", + "design", + "redesigned", + "atomic", + "chain", + "used", "functional", "explicitly", - "4", - "closely", - "specific", - "activity", - "rate", - "bundle", + "geoseqbuilder", + "produce", + "altered", + "testing", + "tested", + "tool", + "prediction", + "complete", "type", - "predicting", - "design", - "core", - "soluble", + "improved", + "leading", + "glutathione", + "sequence", + "uses", + "solved", + "https", + "designed", + "hallucinated", + "models", + "generation", + "sequences", + "structures", + "expressed", + "first", + "3", + "comparable", + "predefined", + "monomeric", "introduce", - "hydrophobic", + "powerful", + "closely", + "interactions", + "4", "high", - "sequence", - "key", - "learning", - "designs", - "tested", - "proteinmpnn", - "accurately", - "success", - "thioredoxin", - "experimental", - "residues", - "neighboring", - "needed", - "leading", - "creating", + "activity", + "native", + "generated", "cores", - "protein", - "residue", - "15", - "2", - "deep", - "side", - "tool", - "new" + "conformations", + "similarity", + "achieves", + "designs", + "novel" ], "release_date":"2024-10-02", - "publication":"\"All-Atom Protein Sequence Design Based on Geometric Deep Learning\", Angew.Chem.Int.Ed.Engl., e202411461-e202411461", + "publication":"\"All-Atom Protein Sequence Design Based on Geometric Deep Learning\", Angew.Chem.Int.Ed.Engl., 63", "publication_ref":{ "DOI":"10.1002\/anie.202411461", "PubMed":"39295564", @@ -965128,115 +969326,115 @@ "de novo protein" ], "keywords":[ - "thermal", - "spatial", - "monomeric", - "available", - "glutathione", - "details", - "low", - "hallucinated", - "expressed", - "designed", - "prediction", - "generated", - "uses", "recovery", - "achieves", - "improved", + "demonstrates", + "rate", + "minimum", + "learning", + "hydrophobic", + "key", "methods", - "complete", + "23", + "experimental", + "neighboring", + "core", + "spatial", + "side", + "framework", + "details", + "new", + "residue", + "protein", + "significantly", + "5", + "showed", + "predicting", + "match", + "accurately", + "original", "crystal", + "creating", + "deep", "geometric", - "features", - "sequences", - "altered", - "interactions", + "needed", "conformation", - "similarity", - "designing", - "23", "backbones", - "novel", - "conformations", - "geoseqbuilder", - "5", - "original", - "chain", - "proteins", - "models", - "testing", - "solved", - "redesigned", - "produce", + "soluble", + "step", + "integrates", + "residues", + "specific", "although", + "thermal", + "thioredoxin", + "stability", + "proteins", + "low", + "includes", + "2", + "success", "enzyme", - "https", - "used", - "demonstrates", + "available", + "15", "peroxidase", - "step", - "3", - "match", - "comparable", - "structures", - "includes", - "integrates", - "atomic", - "showed", - "minimum", - "native", - "significantly", + "features", + "bundle", + "proteinmpnn", + "designing", "exhibit", - "first", - "stability", - "framework", - "generation", - "powerful", - "predefined", + "design", + "redesigned", + "atomic", + "chain", + "used", "functional", "explicitly", - "4", - "closely", - "specific", - "activity", - "rate", - "bundle", + "geoseqbuilder", + "produce", + "altered", + "testing", + "tested", + "tool", + "prediction", + "complete", "type", - "predicting", - "design", - "core", - "soluble", + "improved", + "leading", + "glutathione", + "sequence", + "uses", + "solved", + "https", + "designed", + "hallucinated", + "models", + "generation", + "sequences", + "structures", + "expressed", + "first", + "3", + "comparable", + "predefined", + "monomeric", "introduce", - "hydrophobic", + "powerful", + "closely", + "interactions", + "4", "high", - "sequence", - "key", - "learning", - "designs", - "tested", - "proteinmpnn", - "accurately", - "success", - "thioredoxin", - "experimental", - "residues", - "neighboring", - "needed", - "leading", - "creating", + "activity", + "native", + "generated", "cores", - "protein", - "residue", - "15", - "2", - "deep", - "side", - "tool", - "new" + "conformations", + "similarity", + "achieves", + "designs", + "novel" ], "release_date":"2024-10-02", - "publication":"\"All-Atom Protein Sequence Design Based on Geometric Deep Learning\", Angew.Chem.Int.Ed.Engl., e202411461-e202411461", + "publication":"\"All-Atom Protein Sequence Design Based on Geometric Deep Learning\", Angew.Chem.Int.Ed.Engl., 63", "publication_ref":{ "DOI":"10.1002\/anie.202411461", "PubMed":"39295564", @@ -965554,115 +969752,115 @@ "de novo protein" ], "keywords":[ - "thermal", - "spatial", - "monomeric", - "available", - "glutathione", - "details", - "low", - "hallucinated", - "expressed", - "designed", - "prediction", - "generated", - "uses", "recovery", - "achieves", - "improved", + "demonstrates", + "rate", + "minimum", + "learning", + "hydrophobic", + "key", "methods", - "complete", + "23", + "experimental", + "neighboring", + "core", + "spatial", + "side", + "framework", + "details", + "new", + "residue", + "protein", + "significantly", + "5", + "showed", + "predicting", + "match", + "accurately", + "original", "crystal", + "creating", + "deep", "geometric", - "features", - "sequences", - "altered", - "interactions", + "needed", "conformation", - "similarity", - "designing", - "23", "backbones", - "novel", - "conformations", - "geoseqbuilder", - "5", - "original", - "chain", - "proteins", - "models", - "testing", - "solved", - "redesigned", - "produce", + "soluble", + "step", + "integrates", + "residues", + "specific", "although", + "thermal", + "thioredoxin", + "stability", + "proteins", + "low", + "includes", + "2", + "success", "enzyme", - "https", - "used", - "demonstrates", + "available", + "15", "peroxidase", - "step", - "3", - "match", - "comparable", - "structures", - "includes", - "integrates", - "atomic", - "showed", - "minimum", - "native", - "significantly", + "features", + "bundle", + "proteinmpnn", + "designing", "exhibit", - "first", - "stability", - "framework", - "generation", - "powerful", - "predefined", + "design", + "redesigned", + "atomic", + "chain", + "used", "functional", "explicitly", - "4", - "closely", - "specific", - "activity", - "rate", - "bundle", + "geoseqbuilder", + "produce", + "altered", + "testing", + "tested", + "tool", + "prediction", + "complete", "type", - "predicting", - "design", - "core", - "soluble", + "improved", + "leading", + "glutathione", + "sequence", + "uses", + "solved", + "https", + "designed", + "hallucinated", + "models", + "generation", + "sequences", + "structures", + "expressed", + "first", + "3", + "comparable", + "predefined", + "monomeric", "introduce", - "hydrophobic", + "powerful", + "closely", + "interactions", + "4", "high", - "sequence", - "key", - "learning", - "designs", - "tested", - "proteinmpnn", - "accurately", - "success", - "thioredoxin", - "experimental", - "residues", - "neighboring", - "needed", - "leading", - "creating", + "activity", + "native", + "generated", "cores", - "protein", - "residue", - "15", - "2", - "deep", - "side", - "tool", - "new" + "conformations", + "similarity", + "achieves", + "designs", + "novel" ], "release_date":"2024-10-02", - "publication":"\"All-Atom Protein Sequence Design Based on Geometric Deep Learning\", Angew.Chem.Int.Ed.Engl., e202411461-e202411461", + "publication":"\"All-Atom Protein Sequence Design Based on Geometric Deep Learning\", Angew.Chem.Int.Ed.Engl., 63", "publication_ref":{ "DOI":"10.1002\/anie.202411461", "PubMed":"39295564", @@ -965767,115 +969965,115 @@ "de novo protein" ], "keywords":[ - "thermal", - "spatial", - "monomeric", - "available", - "glutathione", - "details", - "low", - "hallucinated", - "expressed", - "designed", - "prediction", - "generated", - "uses", "recovery", - "achieves", - "improved", + "demonstrates", + "rate", + "minimum", + "learning", + "hydrophobic", + "key", "methods", - "complete", + "23", + "experimental", + "neighboring", + "core", + "spatial", + "side", + "framework", + "details", + "new", + "residue", + "protein", + "significantly", + "5", + "showed", + "predicting", + "match", + "accurately", + "original", "crystal", + "creating", + "deep", "geometric", - "features", - "sequences", - "altered", - "interactions", + "needed", "conformation", - "similarity", - "designing", - "23", "backbones", - "novel", - "conformations", - "geoseqbuilder", - "5", - "original", - "chain", - "proteins", - "models", - "testing", - "solved", - "redesigned", - "produce", + "soluble", + "step", + "integrates", + "residues", + "specific", "although", + "thermal", + "thioredoxin", + "stability", + "proteins", + "low", + "includes", + "2", + "success", "enzyme", - "https", - "used", - "demonstrates", + "available", + "15", "peroxidase", - "step", - "3", - "match", - "comparable", - "structures", - "includes", - "integrates", - "atomic", - "showed", - "minimum", - "native", - "significantly", + "features", + "bundle", + "proteinmpnn", + "designing", "exhibit", - "first", - "stability", - "framework", - "generation", - "powerful", - "predefined", + "design", + "redesigned", + "atomic", + "chain", + "used", "functional", "explicitly", - "4", - "closely", - "specific", - "activity", - "rate", - "bundle", + "geoseqbuilder", + "produce", + "altered", + "testing", + "tested", + "tool", + "prediction", + "complete", "type", - "predicting", - "design", - "core", - "soluble", + "improved", + "leading", + "glutathione", + "sequence", + "uses", + "solved", + "https", + "designed", + "hallucinated", + "models", + "generation", + "sequences", + "structures", + "expressed", + "first", + "3", + "comparable", + "predefined", + "monomeric", "introduce", - "hydrophobic", + "powerful", + "closely", + "interactions", + "4", "high", - "sequence", - "key", - "learning", - "designs", - "tested", - "proteinmpnn", - "accurately", - "success", - "thioredoxin", - "experimental", - "residues", - "neighboring", - "needed", - "leading", - "creating", + "activity", + "native", + "generated", "cores", - "protein", - "residue", - "15", - "2", - "deep", - "side", - "tool", - "new" + "conformations", + "similarity", + "achieves", + "designs", + "novel" ], "release_date":"2024-10-02", - "publication":"\"All-Atom Protein Sequence Design Based on Geometric Deep Learning\", Angew.Chem.Int.Ed.Engl., e202411461-e202411461", + "publication":"\"All-Atom Protein Sequence Design Based on Geometric Deep Learning\", Angew.Chem.Int.Ed.Engl., 63", "publication_ref":{ "DOI":"10.1002\/anie.202411461", "PubMed":"39295564", @@ -965951,11 +970149,11 @@ }, { "sim":121.0, - "partner":"2yj7" + "partner":"2puk" }, { "sim":121.0, - "partner":"2puk" + "partner":"2yj7" }, { "sim":120.0, @@ -966019,15 +970217,15 @@ }, { "sim":104.0, - "partner":"6y4y" + "partner":"6y4z" }, { "sim":104.0, - "partner":"6y4z" + "partner":"6y73" }, { "sim":104.0, - "partner":"6y73" + "partner":"6y4y" }, { "sim":104.0, @@ -966107,11 +970305,11 @@ }, { "sim":96.0, - "partner":"1nw2" + "partner":"5ikn" }, { "sim":96.0, - "partner":"5ikn" + "partner":"1nw2" }, { "sim":96.0, @@ -966149,10 +970347,6 @@ "sim":95.0, "partner":"2i4a" }, - { - "sim":95.0, - "partner":"1tk5" - }, { "sim":95.0, "partner":"1sl0" @@ -966245,6 +970439,10 @@ "sim":95.0, "partner":"1t8e" }, + { + "sim":95.0, + "partner":"1tk5" + }, { "sim":95.0, "partner":"6p7e" @@ -966255,11 +970453,11 @@ }, { "sim":95.0, - "partner":"5hr1" + "partner":"6n7w" }, { "sim":95.0, - "partner":"6n7w" + "partner":"5hr1" }, { "sim":95.0, @@ -966299,11 +970497,11 @@ }, { "sim":94.0, - "partner":"7scd" + "partner":"7sce" }, { "sim":94.0, - "partner":"7sce" + "partner":"7scd" }, { "sim":94.0, @@ -966339,11 +970537,11 @@ }, { "sim":93.0, - "partner":"6nup" + "partner":"6mza" }, { "sim":93.0, - "partner":"6mza" + "partner":"6nup" }, { "sim":92.0, @@ -966665,10 +970863,6 @@ "sim":72.0, "partner":"5ykw" }, - { - "sim":72.0, - "partner":"6q6v" - }, { "sim":72.0, "partner":"1ti3" @@ -966681,6 +970875,10 @@ "sim":72.0, "partner":"6q6u" }, + { + "sim":72.0, + "partner":"6q6v" + }, { "sim":72.0, "partner":"4j56" @@ -966699,11 +970897,11 @@ }, { "sim":70.0, - "partner":"3qfb" + "partner":"3qfa" }, { "sim":70.0, - "partner":"3qfa" + "partner":"3qfb" }, { "sim":69.0, @@ -966723,15 +970921,15 @@ }, { "sim":68.0, - "partner":"1xwb" + "partner":"1xw9" }, { "sim":68.0, - "partner":"1xwc" + "partner":"1xwb" }, { "sim":68.0, - "partner":"1xw9" + "partner":"1xwc" }, { "sim":68.0, @@ -966823,11 +971021,11 @@ }, { "sim":66.0, - "partner":"7p9d" + "partner":"7p9e" }, { "sim":66.0, - "partner":"7p9e" + "partner":"7p9d" }, { "sim":65.0, @@ -966835,15 +971033,15 @@ }, { "sim":65.0, - "partner":"5nyk" + "partner":"5nym" }, { "sim":65.0, - "partner":"5nym" + "partner":"5nyn" }, { "sim":65.0, - "partner":"5nyn" + "partner":"5nyk" }, { "sim":65.0, @@ -966959,35 +971157,35 @@ }, { "sim":61.0, - "partner":"1mdj" + "partner":"4ll1" }, { "sim":61.0, - "partner":"4ll4" + "partner":"1cqg" }, { "sim":61.0, - "partner":"1mdk" + "partner":"1cqh" }, { "sim":61.0, - "partner":"1cqg" + "partner":"4i8b" }, { "sim":61.0, - "partner":"4ll1" + "partner":"1mdi" }, { "sim":61.0, - "partner":"1cqh" + "partner":"4ll4" }, { "sim":61.0, - "partner":"4i8b" + "partner":"1mdj" }, { "sim":61.0, - "partner":"1mdi" + "partner":"1mdk" }, { "sim":60.0, @@ -967203,11 +971401,11 @@ }, { "sim":51.0, - "partner":"2pu9" + "partner":"2pvo" }, { "sim":51.0, - "partner":"2pvo" + "partner":"2pu9" }, { "sim":51.0, @@ -967227,15 +971425,15 @@ }, { "sim":50.0, - "partner":"7moq" + "partner":"6zyw" }, { "sim":50.0, - "partner":"6zyw" + "partner":"8bwy" }, { "sim":50.0, - "partner":"8bwy" + "partner":"7moq" }, { "sim":50.0, @@ -967356,90 +971554,90 @@ ], "subtitle":"A near-infrared fluorescent protein of de novo backbone design", "tags":[ - "de novo backbone design", "monomerization", "de novo protein", - "near-infrared fluorescent protein" + "near-infrared fluorescent protein", + "de novo backbone design" ], "keywords":[ - "evolution", - "monomeric", - "use", - "imaging", + "molecular", + "shield", + "nir", + "13", + "fluorescent", + "new", "strategy", - "place", - "designed", + "protein", + "binding", + "weight", + "confirmed", + "apo", + "forms", + "systems", "potentially", - "experimentally", - "crystal", - "dmsmurfp", - "determined", - "based", - "enhanced", - "structure", - "applied", - "monomerize", - "fluorescence", - "biliverdin", "original", - "chain", - "proteins", - "employed", - "characterized", - "covering", - "kda", - "small", - "interface", - "used", "intersubunit", + "two", + "crystal", + "weak", + "stable", "binds", - "smurfp", - "structures", - "naturally", - "mammalian", - "suitable", - "second", - "multimeric", - "systems", + "helices", + "complex", + "characterized", + "dimer", + "experimentally", + "monomerize", + "place", + "covering", + "proteins", + "sites", "rounds", - "fluorescent", + "use", + "segment", + "biliverdin", + "interface", + "small", + "evolution", "obtained", - "molecular", - "demonstrated", - "functional", - "bright", - "engineer", - "dimer", - "fp", - "apo", + "pocket", + "mammalian", "design", - "weight", - "weak", - "nir", - "segment", - "13", - "sites", - "designs", - "helices", + "enhanced", + "chain", + "used", + "functional", + "dmsmurfp", "also", - "stable", - "directed", - "confirmed", - "two", - "state", - "protein", - "shield", - "complex", + "kda", "backbone", - "bioimaging", - "extend", + "applied", + "demonstrated", "chromophore", - "ultrared", + "engineer", + "fluorescence", + "designed", + "employed", + "directed", + "naturally", "vivo", - "pocket", - "binding", - "forms", - "new" + "structures", + "fp", + "suitable", + "smurfp", + "imaging", + "based", + "structure", + "monomeric", + "determined", + "bioimaging", + "multimeric", + "state", + "bright", + "ultrared", + "extend", + "second", + "designs" ], "release_date":"2024-02-28", "publication":"\"Using Protein Design and Directed Evolution to Monomerize a Bright Near-Infrared Fluorescent Protein\", Acs Synth Biol, 13, 1177-1190", @@ -967472,11 +971670,11 @@ "seq_thr_sim_designed":[ { "sim":377.0, - "partner":"8j1x" + "partner":"8j98" }, { "sim":377.0, - "partner":"8j98" + "partner":"8j1x" }, { "sim":369.0, @@ -967510,15 +971708,15 @@ }, { "sim":140.0, - "partner":"7sc9" + "partner":"7sc7" }, { "sim":140.0, - "partner":"7sc7" + "partner":"7scb" }, { "sim":140.0, - "partner":"7scb" + "partner":"7sc9" }, { "sim":138.0, @@ -967526,23 +971724,23 @@ }, { "sim":136.0, - "partner":"6kgx" + "partner":"7ezx" }, { "sim":136.0, - "partner":"7y7a" + "partner":"7y4l" }, { "sim":136.0, - "partner":"7ezx" + "partner":"7y5e" }, { "sim":136.0, - "partner":"7y4l" + "partner":"6kgx" }, { "sim":136.0, - "partner":"7y5e" + "partner":"7y7a" }, { "sim":132.0, @@ -967606,11 +971804,11 @@ }, { "sim":100.0, - "partner":"8imj" + "partner":"8imk" }, { "sim":100.0, - "partner":"8imk" + "partner":"8imj" }, { "sim":98.0, @@ -967630,15 +971828,15 @@ }, { "sim":65.0, - "partner":"2c7j" + "partner":"2c7k" }, { "sim":65.0, - "partner":"2c7k" + "partner":"2c7l" }, { "sim":65.0, - "partner":"2c7l" + "partner":"2c7j" }, { "sim":63.0, @@ -967652,10 +971850,6 @@ "sim":61.0, "partner":"8iml" }, - { - "sim":61.0, - "partner":"8imo" - }, { "sim":61.0, "partner":"8imm" @@ -967665,12 +971859,8 @@ "partner":"8imn" }, { - "sim":60.0, - "partner":"7d6w" - }, - { - "sim":60.0, - "partner":"2uul" + "sim":61.0, + "partner":"8imo" }, { "sim":60.0, @@ -967688,6 +971878,10 @@ "sim":60.0, "partner":"1gh0" }, + { + "sim":60.0, + "partner":"7d6w" + }, { "sim":60.0, "partner":"2uum" @@ -967696,6 +971890,10 @@ "sim":60.0, "partner":"4f0t" }, + { + "sim":60.0, + "partner":"2uul" + }, { "sim":60.0, "partner":"4h0m" @@ -967722,20 +971920,12 @@ }, { "sim":58.0, - "partner":"6ypq" + "partner":"7eh7" }, { "sim":58.0, "partner":"7veb" }, - { - "sim":58.0, - "partner":"4gy3" - }, - { - "sim":58.0, - "partner":"4n6s" - }, { "sim":58.0, "partner":"3l0f" @@ -967746,11 +971936,11 @@ }, { "sim":58.0, - "partner":"1i7y" + "partner":"6xwk" }, { "sim":58.0, - "partner":"7eh7" + "partner":"7efv" }, { "sim":58.0, @@ -967758,27 +971948,23 @@ }, { "sim":58.0, - "partner":"6xwk" + "partner":"1i7y" }, { "sim":58.0, - "partner":"1jbo" + "partner":"8fwa" }, { "sim":58.0, "partner":"4gxe" }, - { - "sim":58.0, - "partner":"7efv" - }, { "sim":58.0, "partner":"1ktp" }, { "sim":58.0, - "partner":"8fwa" + "partner":"1jbo" }, { "sim":58.0, @@ -967790,19 +971976,19 @@ }, { "sim":58.0, - "partner":"4ziz" + "partner":"7efw" }, { "sim":58.0, - "partner":"1ha7" + "partner":"4ziz" }, { "sim":58.0, - "partner":"1on7" + "partner":"7eh8" }, { "sim":58.0, - "partner":"7efw" + "partner":"1on7" }, { "sim":58.0, @@ -967810,7 +971996,7 @@ }, { "sim":58.0, - "partner":"7eh8" + "partner":"1ha7" }, { "sim":58.0, @@ -967822,11 +972008,11 @@ }, { "sim":58.0, - "partner":"3o18" + "partner":"6yyj" }, { "sim":58.0, - "partner":"6yyj" + "partner":"3o18" }, { "sim":58.0, @@ -967840,22 +972026,34 @@ "sim":58.0, "partner":"5mjq" }, + { + "sim":58.0, + "partner":"6yq8" + }, { "sim":58.0, "partner":"5o7m" }, { "sim":58.0, - "partner":"6yq8" + "partner":"6ypq" }, { - "sim":57.0, - "partner":"6y3d" + "sim":58.0, + "partner":"4gy3" + }, + { + "sim":58.0, + "partner":"4n6s" }, { "sim":57.0, "partner":"6hrn" }, + { + "sim":57.0, + "partner":"6y3d" + }, { "sim":57.0, "partner":"7s96" @@ -967886,7 +972084,7 @@ }, { "sim":55.0, - "partner":"4lm6" + "partner":"7tlf" }, { "sim":55.0, @@ -967894,7 +972092,7 @@ }, { "sim":55.0, - "partner":"7tlf" + "partner":"4lm6" }, { "sim":54.0, @@ -967926,15 +972124,11 @@ }, { "sim":51.0, - "partner":"7sut" - }, - { - "sim":51.0, - "partner":"8el3" + "partner":"7ssf" }, { "sim":51.0, - "partner":"7ssf" + "partner":"8el4" }, { "sim":51.0, @@ -967942,19 +972136,19 @@ }, { "sim":51.0, - "partner":"8el4" + "partner":"8el5" }, { "sim":51.0, - "partner":"8el5" + "partner":"8el6" }, { "sim":51.0, - "partner":"8el6" + "partner":"7sut" }, { - "sim":50.0, - "partner":"3v57" + "sim":51.0, + "partner":"8el3" }, { "sim":50.0, @@ -967968,6 +972162,10 @@ "sim":50.0, "partner":"8b4n" }, + { + "sim":50.0, + "partner":"3v57" + }, { "sim":50.0, "partner":"1xg0" @@ -967996,7 +972194,7 @@ ], "seq_max_sim_designed":{ "sim":377.0, - "partner":"8j1x" + "partner":"8j98" }, "seq_max_sim_natural":{ "sim":231.0, @@ -968074,93 +972272,93 @@ ], "subtitle":"Tcdb1 in complex with mini-binder", "tags":[ - "mini-binder against c.difficle infection", "toxin-de novo protein complex", + "mini-binder against c.difficle infection", "toxin\/de novo protein" ], "keywords":[ - "pm", - "nm", - "challenge", - "receptor", - "provide", "neutralize", - "findings", - "consistent", - "starting", - "poses", - "models", + "sulfate", + "development", + "accounting", + "key", + "exhibiting", + "varied", + "points", + "difficile", + "successfully", + "protein", + "binding", + "microscopy", "rbi", - "neutralizing", - "assay", - "de", + "novo", + "b", + "cells", + "virulence", + "major", + "clostridioides", + "proteoglycan", + "binds", + "10", + "tcdb4", + "using", + "receptor", + "cdi", + "complex", + "engineered", + "starting", + "symptoms", + "20", + "valuable", + "characterization", + "factor", "binder", - "variants", - "successfully", - "effectively", "interface", + "subtypes", + "mice", + "female", + "computational", + "cspg4", + "design", + "pm", + "another", "binders", - "binds", - "mini", - "better", - "tcdb4", - "structures", "therapeutics", - "virulence", "natural", - "solution", - "difficile", - "evolved", - "first", - "second", + "different", + "nm", "targeting", - "sulfate", - "valuable", + "infections", + "solution", "demonstrated", - "another", - "cspg4", - "ranging", - "4", - "exhibiting", - "10", - "cdi", - "mice", - "universal", - "points", - "accounting", - "symptoms", - "design", - "characterization", - "using", + "neutralizing", + "effectively", "present", + "universal", + "evolved", + "assay", + "models", + "vivo", + "variants", + "poses", + "structures", + "de", + "ranging", "tcdb1", - "tcdb", - "key", - "cells", - "factor", - "infections", - "novo", - "engineered", - "different", - "affinities", - "varied", + "first", + "toxin", + "provide", + "findings", + "4", "chondroitin", - "clostridioides", - "female", "significant", - "b", - "microscopy", - "protein", - "complex", - "development", - "computational", - "vivo", - "proteoglycan", - "20", - "subtypes", - "major", - "binding", - "toxin" + "tcdb", + "challenge", + "affinities", + "mini", + "second", + "better", + "consistent" ], "release_date":"2024-08-28", "publication":"\"De novo design of mini-protein binders broadly neutralizing Clostridioides difficile toxin B variants\", Nat Commun, 15, 8521-8521", @@ -968284,94 +972482,94 @@ ], "subtitle":"De novo design mini-binder in complex with tcdb4", "tags":[ - "toxin-de novo protein complex", "de novo protein", + "toxin-de novo protein complex", "toxin\/de novo protein", "de novo design mini-binder against c.difficle toxin b" ], "keywords":[ - "pm", - "nm", - "challenge", - "receptor", - "provide", "neutralize", - "findings", - "consistent", - "starting", - "poses", - "models", + "sulfate", + "development", + "accounting", + "key", + "exhibiting", + "varied", + "points", + "difficile", + "successfully", + "protein", + "binding", + "microscopy", "rbi", - "neutralizing", - "assay", - "de", + "novo", + "b", + "cells", + "virulence", + "major", + "clostridioides", + "proteoglycan", + "binds", + "10", + "tcdb4", + "using", + "receptor", + "cdi", + "complex", + "engineered", + "starting", + "symptoms", + "20", + "valuable", + "characterization", + "factor", "binder", - "variants", - "successfully", - "effectively", "interface", + "subtypes", + "mice", + "female", + "computational", + "cspg4", + "design", + "pm", + "another", "binders", - "binds", - "mini", - "better", - "tcdb4", - "structures", "therapeutics", - "virulence", "natural", - "solution", - "difficile", - "evolved", - "first", - "second", + "different", + "nm", "targeting", - "sulfate", - "valuable", + "infections", + "solution", "demonstrated", - "another", - "cspg4", - "ranging", - "4", - "exhibiting", - "10", - "cdi", - "mice", - "universal", - "points", - "accounting", - "symptoms", - "design", - "characterization", - "using", + "neutralizing", + "effectively", "present", + "universal", + "evolved", + "assay", + "models", + "vivo", + "variants", + "poses", + "structures", + "de", + "ranging", "tcdb1", - "tcdb", - "key", - "cells", - "factor", - "infections", - "novo", - "engineered", - "different", - "affinities", - "varied", + "first", + "toxin", + "provide", + "findings", + "4", "chondroitin", - "clostridioides", - "female", "significant", - "b", - "microscopy", - "protein", - "complex", - "development", - "computational", - "vivo", - "proteoglycan", - "20", - "subtypes", - "major", - "binding", - "toxin" + "tcdb", + "challenge", + "affinities", + "mini", + "second", + "better", + "consistent" ], "release_date":"2024-08-28", "publication":"\"De novo design of mini-protein binders broadly neutralizing Clostridioides difficile toxin B variants\", Nat Commun, 15, 8521-8521", @@ -968655,83 +972853,83 @@ "subtitle":"Cryo-em of azo-ffspy fiber", "tags":[ "helical", + "peptide-fiber", "protein fibril", - "d-peptide", - "peptide-fiber" + "d-peptide" ], "keywords":[ - "depending", + "thinning", + "complex", "relies", - "morphologies", - "demonstrate", - "vertical", - "unexpected", - "mimics", - "one", - "indicating", - "challenges", - "serving", - "reveals", + "demonstrates", + "nanostructures", + "example", + "pillars", + "embryos", + "driving", "presents", - "growth", - "thinning", - "assemblies", - "approach", "bundles", - "changes", - "process", - "study", - "sculpting", - "remodel", - "fibronectin", + "one", + "collagen", + "governed", "recruit", + "concentrations", + "constructing", "multiprotein", - "template", - "composition", - "nanopillars", - "peptide", - "enzyme", - "shape", - "method", - "example", - "demonstrates", - "intricate", - "collagen", - "nanostructures", - "aggregates", - "phosphopeptides", - "assemble", "observed", - "utilizes", - "constructing", - "action", "creation", - "protein", - "using", - "driving", - "complex", - "outside", - "nanotube", - "structure", + "nonequilibrium", + "action", + "serving", + "triggers", "assembly", - "governed", - "types", - "pillar", - "dephosphorylation", + "structure", + "challenges", + "indicating", + "intricate", + "shape", + "nanotubes", + "template", "directionality", - "replicating", - "triggers", + "morphologies", + "fibronectin", + "protein", + "study", + "depending", + "approach", + "utilizes", + "packing", + "changes", + "process", + "mimics", "formation", + "replicating", + "phosphopeptides", + "demonstrate", "cells", - "nanopillar", - "embryos", - "packing", - "nonequilibrium", - "forms", + "types", + "enzyme", + "reveals", + "vertical", + "outside", "contain", - "nanotubes", - "pillars", - "concentrations" + "forms", + "remodel", + "dephosphorylation", + "unexpected", + "sculpting", + "composition", + "using", + "assemble", + "aggregates", + "assemblies", + "nanotube", + "growth", + "nanopillars", + "method", + "pillar", + "peptide", + "nanopillar" ], "release_date":"2024-09-18", "publication":"\"Cell-Free Nonequilibrium Assembly for Hierarchical Protein\/Peptide Nanopillars\", J.Am.Chem.Soc., 146, 26102-26112", @@ -968874,83 +973072,83 @@ "subtitle":"Cryo-em of azo-ffsy fiber", "tags":[ "helical", + "peptide-fiber", "protein fibril", - "d-peptide", - "peptide-fiber" + "d-peptide" ], "keywords":[ - "depending", + "thinning", + "complex", "relies", - "morphologies", - "demonstrate", - "vertical", - "unexpected", - "mimics", - "one", - "indicating", - "challenges", - "serving", - "reveals", + "demonstrates", + "nanostructures", + "example", + "pillars", + "embryos", + "driving", "presents", - "growth", - "thinning", - "assemblies", - "approach", "bundles", - "changes", - "process", - "study", - "sculpting", - "remodel", - "fibronectin", + "one", + "collagen", + "governed", "recruit", + "concentrations", + "constructing", "multiprotein", - "template", - "composition", - "nanopillars", - "peptide", - "enzyme", - "shape", - "method", - "example", - "demonstrates", - "intricate", - "collagen", - "nanostructures", - "aggregates", - "phosphopeptides", - "assemble", "observed", - "utilizes", - "constructing", - "action", "creation", - "protein", - "using", - "driving", - "complex", - "outside", - "nanotube", - "structure", + "nonequilibrium", + "action", + "serving", + "triggers", "assembly", - "governed", - "types", - "pillar", - "dephosphorylation", + "structure", + "challenges", + "indicating", + "intricate", + "shape", + "nanotubes", + "template", "directionality", - "replicating", - "triggers", + "morphologies", + "fibronectin", + "protein", + "study", + "depending", + "approach", + "utilizes", + "packing", + "changes", + "process", + "mimics", "formation", + "replicating", + "phosphopeptides", + "demonstrate", "cells", - "nanopillar", - "embryos", - "packing", - "nonequilibrium", - "forms", + "types", + "enzyme", + "reveals", + "vertical", + "outside", "contain", - "nanotubes", - "pillars", - "concentrations" + "forms", + "remodel", + "dephosphorylation", + "unexpected", + "sculpting", + "composition", + "using", + "assemble", + "aggregates", + "assemblies", + "nanotube", + "growth", + "nanopillars", + "method", + "pillar", + "peptide", + "nanopillar" ], "release_date":"2024-09-18", "publication":"\"Cell-Free Nonequilibrium Assembly for Hierarchical Protein\/Peptide Nanopillars\", J.Am.Chem.Soc., 146, 26102-26112", @@ -969054,12 +973252,12 @@ "subtitle":"Structure of lng binder complex", "tags":[ "de novo protein\/toxin", - "deep learning", - "protein design", + "cobra toxin", "de novo protein", - "de novo protein-toxin complex", "diffusion", - "cobra toxin" + "de novo protein-toxin complex", + "deep learning", + "protein design" ], "keywords":[ "description", @@ -969168,13 +973366,13 @@ ], "subtitle":"Structure of b10_cytx binder-complex", "tags":[ - "de novo protein\/toxin", - "deep learning", - "protein design", "cytotoxins", + "de novo protein\/toxin", "de novo protein", + "diffusion", "de novo protein-toxin complex", - "diffusion" + "deep learning", + "protein design" ], "keywords":[ "description", @@ -969253,13 +973451,133 @@ ], "authors":[ { - "forename":"S.V.", - "surname":"Torres" + "forename":"S.", + "surname":"Vazquez Torres" + }, + { + "forename":"M.", + "surname":"Benard Valle" + }, + { + "forename":"S.P.", + "surname":"Mackessy" + }, + { + "forename":"S.K.", + "surname":"Menzies" + }, + { + "forename":"N.R.", + "surname":"Casewell" + }, + { + "forename":"S.", + "surname":"Ahmadi" + }, + { + "forename":"N.J.", + "surname":"Burlet" + }, + { + "forename":"E.", + "surname":"Muratspahic" + }, + { + "forename":"I.", + "surname":"Sappington" + }, + { + "forename":"M.D.", + "surname":"Overath" + }, + { + "forename":"E.", + "surname":"Rivera-de-Torre" + }, + { + "forename":"J.", + "surname":"Ledergerber" + }, + { + "forename":"A.H.", + "surname":"Laustsen" + }, + { + "forename":"K.", + "surname":"Boddum" }, { "forename":"A.K.", "surname":"Bera" }, + { + "forename":"A.", + "surname":"Kang" + }, + { + "forename":"E.", + "surname":"Brackenbrough" + }, + { + "forename":"I.A.", + "surname":"Cardoso" + }, + { + "forename":"E.P.", + "surname":"Crittenden" + }, + { + "forename":"R.J.", + "surname":"Edge" + }, + { + "forename":"J.", + "surname":"Decarreau" + }, + { + "forename":"R.J.", + "surname":"Ragotte" + }, + { + "forename":"A.S.", + "surname":"Pillai" + }, + { + "forename":"M.", + "surname":"Abedi" + }, + { + "forename":"H.L.", + "surname":"Han" + }, + { + "forename":"S.R.", + "surname":"Gerben" + }, + { + "forename":"A.", + "surname":"Murray" + }, + { + "forename":"R.", + "surname":"Skotheim" + }, + { + "forename":"L.", + "surname":"Stuart" + }, + { + "forename":"L.", + "surname":"Stewart" + }, + { + "forename":"T.J.A.", + "surname":"Fryer" + }, + { + "forename":"T.P.", + "surname":"Jenkins" + }, { "forename":"D.", "surname":"Baker" @@ -969275,27 +973593,142 @@ ], "subtitle":"Structure of shrt_binder", "tags":[ + "de novo protein", + "diffusion", "shrt_binder", "deep learning", - "protein design", - "de novo protein", - "diffusion" + "protein design" ], "keywords":[ - "description", - "found" + "affinity", + "treatments", + "disease", + "annually", + "limited", + "learning", + "development", + "methods", + "experimental", + "requirements", + "antivenom", + "three", + "results", + "therapies", + "damage", + "protein", + "readily", + "tissue", + "vitro", + "binding", + "novo", + "envenoming", + "cytotoxins", + "subfamilies", + "stable", + "consist", + "immunized", + "elapid", + "snakebites", + "manufacturable", + "cause", + "resource", + "deep", + "lethal", + "tropical", + "democratize", + "neglected", + "agreement", + "accessible", + "particularly", + "family", + "widely", + "neurotoxicity", + "thermal", + "derived", + "bind", + "basis", + "stability", + "proteins", + "remarkable", + "highly", + "available", + "components", + "snake", + "mice", + "pathologies", + "costs", + "reducing", + "safer", + "computational", + "toxins", + "including", + "obtained", + "toxic", + "highlight", + "design", + "diverse", + "help", + "used", + "therapeutics", + "venoms", + "beyond", + "therapeutic", + "complications", + "claiming", + "protected", + "settings", + "substantially", + "polyclonal", + "effectively", + "present", + "inhibition", + "screening", + "could", + "causing", + "designed", + "disabilities", + "models", + "many", + "3ftxs", + "3ftx", + "receptors", + "de", + "acetylcholine", + "efficacy", + "neurotoxin", + "snakebite", + "3", + "remains", + "severe", + "plasma", + "provide", + "resulting", + "lives", + "neutralized", + "devastating", + "4", + "diseases", + "cost", + "high", + "discovery", + "potent", + "designs", + "challenge", + "animals", + "nicotinic", + "antibodies" ], "release_date":"2024-10-09", - "publication":"To be published", + "publication":"\"De novo designed proteins neutralize lethal snake venom toxins\", Nature", "publication_ref":{ - "DOI":"", - "PubMed":"", - "CSD":"", - "ISSN":"", - "ASTM":"" + "DOI":"10.1038\/s41586-024-08393-x", + "PubMed":"39814879", + "CSD":"0006", + "ISSN":"1476-4687", + "ASTM":"NATUAS" }, - "publication_country":"", - "abstract":"No description found.", + "publication_country":"UK", + "abstract":"Snakebite envenoming remains a devastating and neglected tropical disease, claiming over 100,000 lives annually and causing severe complications and long-lasting disabilities for many more 1,2 . Three-finger toxins (3FTx) are highly toxic components of elapid snake venoms that can cause diverse pathologies, including severe tissue damage 3 and inhibition of nicotinic acetylcholine receptors, resulting in life-threatening neurotoxicity 4 . At present, the only available treatments for snakebites consist of polyclonal antibodies derived from the plasma of immunized animals, which have high cost and limited efficacy against 3FTxs 5-7 . Here we used deep learning methods to de novo design proteins to bind short-chain and long-chain \u03b1-neurotoxins and cytotoxins from the 3FTx family. With limited experimental screening, we obtained protein designs with remarkable thermal stability, high binding affinity and near-atomic-level agreement with the computational models. The designed proteins effectively neutralized all three 3FTx subfamilies in vitro and protected mice from a lethal neurotoxin challenge. Such potent, stable and readily manufacturable toxin-neutralizing proteins could provide the basis for safer, cost-effective and widely accessible next-generation antivenom therapeutics. Beyond snakebite, our results highlight how computational design could help democratize therapeutic discovery, particularly in resource-limited settings, by substantially reducing costs and resource requirements for the development of therapies for neglected tropical diseases.", "crystal_structure":{ "length_a":"75.334", "length_b":"75.334", @@ -969399,73 +973832,73 @@ ], "subtitle":"X-ray crystal structure of cu-tz4h tryptophan zipper metallo-peptide", "tags":[ - "hairpin", "de novo protein", "beta-sheet", + "hairpin", "copper" ], "keywords":[ - "supramolecular", - "demonstrate", - "obtained", - "unexpected", - "mimics", - "overall", - "importance", - "many", - "poor", + "designed", "chemistry", - "pathology", + "supramolecular", + "metallopeptides", + "disease", "models", - "proteins", - "available", - "assemblies", - "also", - "elucidating", - "de", - "novo", - "stable", - "cu", + "engineered", + "diffraction", + "many", "metal", + "however", + "structural", + "pursued", + "stark", + "implicated", + "de", + "structures", "metalloproteins", - "contrast", - "ions", "single", - "crystallography", - "peptides", - "designed", - "engineered", - "tryptophan", - "address", - "range", - "landscape", + "triggers", "yet", + "overall", "alzheimer", - "implicated", - "zippers", + "cu", + "rich", "canonical", - "leading", - "crystal", - "pursued", - "find", - "several", - "ii", - "stark", - "examples", - "binding", - "structures", - "bind", + "elucidating", + "also", "findings", - "diffraction", - "underscore", - "understanding", - "triggers", - "rich", - "however", + "pathology", "occurs", - "disease", - "structural", - "metallopeptides" + "crystallography", + "address", + "bind", + "understanding", + "underscore", + "proteins", + "binding", + "examples", + "leading", + "mimics", + "ions", + "several", + "find", + "poor", + "contrast", + "novo", + "zippers", + "demonstrate", + "tryptophan", + "available", + "peptides", + "landscape", + "unexpected", + "crystal", + "stable", + "range", + "assemblies", + "importance", + "obtained", + "ii" ], "release_date":"2024-09-04", "publication":"\"Crystallography Reveals Metal-Triggered Restructuring of beta-Hairpins\", Chemistry, 30, e202402101-e202402101", @@ -969580,67 +974013,67 @@ "beta-sheet" ], "keywords":[ - "supramolecular", - "demonstrate", - "obtained", - "unexpected", - "mimics", - "overall", - "importance", - "many", - "poor", + "designed", "chemistry", - "pathology", + "supramolecular", + "metallopeptides", + "disease", "models", - "proteins", - "available", - "assemblies", - "also", - "elucidating", - "de", - "novo", - "stable", - "cu", + "engineered", + "diffraction", + "many", "metal", + "however", + "structural", + "pursued", + "stark", + "implicated", + "de", + "structures", "metalloproteins", - "contrast", - "ions", "single", - "crystallography", - "peptides", - "designed", - "engineered", - "tryptophan", - "address", - "range", - "landscape", + "triggers", "yet", + "overall", "alzheimer", - "implicated", - "zippers", + "cu", + "rich", "canonical", - "leading", - "crystal", - "pursued", - "find", - "several", - "ii", - "stark", - "examples", - "binding", - "structures", - "bind", + "elucidating", + "also", "findings", - "diffraction", - "underscore", - "understanding", - "triggers", - "rich", - "however", + "pathology", "occurs", - "disease", - "structural", - "metallopeptides" + "crystallography", + "address", + "bind", + "understanding", + "underscore", + "proteins", + "binding", + "examples", + "leading", + "mimics", + "ions", + "several", + "find", + "poor", + "contrast", + "novo", + "zippers", + "demonstrate", + "tryptophan", + "available", + "peptides", + "landscape", + "unexpected", + "crystal", + "stable", + "range", + "assemblies", + "importance", + "obtained", + "ii" ], "release_date":"2024-09-04", "publication":"\"Crystallography Reveals Metal-Triggered Restructuring of beta-Hairpins\", Chemistry, 30, e202402101-e202402101", @@ -969794,82 +974227,82 @@ ], "subtitle":"Crystal structure of tnfr2 tnfr2_mb1 complex", "tags":[ - "tnfr1", + "tnfr2", "de novo protein", "antagonists and agonists", - "tnfr2" + "tnfr1" ], "keywords":[ - "factor", - "designs", - "despite", + "affinity", + "relatively", + "made", + "tnfr1", + "designing", + "superagonists", + "design", + "challenging", "many", - "tested", - "proteins", - "failed", - "hypothesized", + "whose", "specificity", - "higher", + "binders", + "rather", "complexes", - "flat", - "random", - "generate", - "approach", - "tnfr1", - "low", "efforts", - "family", - "presented", - "screening", - "presages", - "superagonists", - "computation", - "valency", - "1", - "shape", - "pharmacologically", - "receptor", - "challenging", - "surfaces", + "progress", "approaches", - "binders", + "computation", "agonists", - "ability", - "made", - "polar", - "obtain", - "picomolar", - "immunization", - "design", - "whose", + "free", + "tested", "partial", - "protein", - "rather", - "noise", - "using", - "diffusion", + "immunization", + "important", + "family", + "pharmacologically", + "shape", "targets", + "polar", + "generate", + "necrosis", + "surfaces", + "era", + "protein", + "function", + "completely", + "approach", + "failed", + "random", + "proteins", + "flat", "members", - "progress", - "ox40", - "designing", - "tumor", + "low", + "valency", + "silico", + "presages", "matching", - "relatively", - "function", + "factor", + "presented", + "1", + "tumor", + "ability", "native", - "antagonists", "switched", - "could", - "silico", - "affinity", + "antagonists", + "noise", + "picomolar", + "ox40", "coming", - "necrosis", - "free", - "completely", - "era", - "important", - "lower" + "despite", + "higher", + "diffusion", + "screening", + "designs", + "hypothesized", + "using", + "lower", + "receptor", + "could", + "obtain" ], "release_date":"2024-12-04", "publication":"\"Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists\", Science, 386, 1154-1161", @@ -969993,75 +974426,75 @@ ], "subtitle":"Constrained b-hairpins targeting the epha4 ligand binding domain", "tags":[ - "receptor tyrosine kinase epha4", - "lipid binding protein" + "lipid binding protein", + "receptor tyrosine kinase epha4" ], "keywords":[ - "great", - "agonistic", - "domain", - "cancers", - "reported", - "pharmacological", - "ligand", - "pancreatic", - "studies", - "phage", - "lack", - "amyotrophic", - "potent", - "kinase", - "strategy", - "inhibitor", - "oncology", - "lateral", - "hold", - "drug", - "including", - "peptide", - "moreover", + "affinity", "designed", - "peptides", - "receptor", - "mimetic", - "validation", - "alzheimer", - "implicated", - "activity", - "gastric", "advances", - "constrained", + "disease", "limited", - "target", - "several", - "based", - "tyrosine", - "design", - "sclerosis", - "binding", - "promise", - "therapeutics", "agents", - "introduce", - "previous", - "validating", + "design", + "constrained", + "however", "development", - "high", - "pathologies", + "validating", + "moreover", + "kinase", + "sclerosis", + "implicated", + "hold", "suitable", + "therapeutics", + "possible", "display", + "agonistic", + "ligand", + "alzheimer", + "domain", + "based", + "targeting", + "great", + "introduce", + "tyrosine", + "inhibitor", + "strategy", + "target", "recently", + "cyclic", "inhibitors", + "previous", + "drug", "diseases", + "oncology", + "binding", + "mimetic", + "several", + "phage", + "amyotrophic", + "high", + "activity", + "pharmacological", + "reported", + "peptides", + "promise", + "lateral", + "studies", + "pathologies", + "potent", "epha4", - "lbd", - "however", - "affinity", "neurodegenerative", - "possible", - "disease", - "cyclic", - "targeting" + "cancers", + "peptide", + "validation", + "lbd", + "gastric", + "including", + "receptor", + "lack", + "pancreatic" ], "release_date":"2024-12-25", "publication":"\"Constrained beta-Hairpins Targeting the EphA4 Ligand Binding Domain\", J.Med.Chem., 67, 22245-22253", @@ -970189,13 +974622,13 @@ "classification_suggested_reason":[ ], - "subtitle":"A darpin fused to the 1tel crystallization chaperone via a direct helical fusion", + "subtitle":"Crystal structure of a darpin fused to the 1tel crystallization chaperone via a direct helical fusion in a 3-fold crystal form", "tags":[ + "darpin", "designed ankyrin repeat protein", - "etv6", + "protein binding", "telsam", - "darpin", - "protein binding" + "etv6" ], "keywords":[ "description", @@ -970329,11 +974762,11 @@ ], "subtitle":"A darpin fused to the 1tel crystallization chaperone via a proline-alanine linker", "tags":[ + "darpin", "designed ankyrin repeat protein", - "etv6", + "protein binding", "telsam", - "darpin", - "protein binding" + "etv6" ], "keywords":[ "description", @@ -970427,11 +974860,11 @@ ], "subtitle":"Ancestral hydroxynitrile lyase with fifteen substitutions", "tags":[ - "esterase", + "engineered protein", "hydroxynitrile lyase", "hydrolase fold", - "lyase", - "engineered protein" + "esterase", + "lyase" ], "keywords":[ "description", @@ -970519,11 +974952,11 @@ }, { "sim":412.0, - "partner":"2yas" + "partner":"7yas" }, { "sim":412.0, - "partner":"7yas" + "partner":"2yas" }, { "sim":412.0, @@ -970609,10 +975042,6 @@ "sim":365.0, "partner":"3wwp" }, - { - "sim":335.0, - "partner":"6coi" - }, { "sim":335.0, "partner":"6cod" @@ -970629,6 +975058,10 @@ "sim":335.0, "partner":"6coh" }, + { + "sim":335.0, + "partner":"6coi" + }, { "sim":332.0, "partner":"6cob" @@ -970655,11 +975088,11 @@ }, { "sim":297.0, - "partner":"1y7i" + "partner":"1y7h" }, { "sim":297.0, - "partner":"1y7h" + "partner":"1y7i" }, { "sim":295.0, @@ -970717,10 +975150,6 @@ "sim":63.0, "partner":"5y51" }, - { - "sim":57.0, - "partner":"7p4k" - }, { "sim":57.0, "partner":"6hgv" @@ -970737,33 +975166,29 @@ "sim":57.0, "partner":"6yl4" }, - { - "sim":57.0, - "partner":"6fr2" - }, { "sim":57.0, "partner":"7a7g" }, { "sim":57.0, - "partner":"8qmz" + "partner":"6fr2" }, { "sim":57.0, - "partner":"8qzd" + "partner":"7p4k" }, { "sim":57.0, - "partner":"8qn0" + "partner":"8qmz" }, { "sim":57.0, - "partner":"4y2x" + "partner":"8qzd" }, { "sim":57.0, - "partner":"4y2y" + "partner":"8qn0" }, { "sim":57.0, @@ -970841,6 +975266,14 @@ "sim":57.0, "partner":"4y2v" }, + { + "sim":57.0, + "partner":"4y2x" + }, + { + "sim":57.0, + "partner":"4y2y" + }, { "sim":52.0, "partner":"6tj2" @@ -970976,90 +975409,90 @@ ], "subtitle":"Pseudosymmetric protein nanocage gi4 -f7 (local refinement)", "tags":[ - "seattle structural genomics center for infectious disease", - "viral protein", "pseudosymmetric protein nanocages", - "structural genomics", + "seattle structural genomics center for infectious disease", "fusion protein", - "ssgcid" + "viral protein", + "ssgcid", + "structural genomics" ], "keywords":[ + "designed", + "960", + "designing", + "limited", + "symmetry", + "design", + "megadaltons", "work", + "240", + "observed", + "used", + "feature", + "ranging", + "progress", + "computationally", + "heterooligomeric", + "3", + "inspired", + "moving", + "biological", + "accessible", + "nm", + "hierarchical", + "capsids", + "specialized", "nanocages", + "new", + "beyond", + "540", + "functions", + "bounded", + "complexity", "largest", - "reliance", - "containing", - "discrete", - "hierarchical", + "protein", + "broadens", "architectures", - "heterooligomeric", - "49", - "megadaltons", - "kilodaltons", - "despite", - "bacterial", - "nm", + "strict", "proteins", - "viral", - "large", - "240", - "accessible", - "components", + "reliance", "remarkable", - "assemblies", + "large", + "71", + "size", + "bacterial", + "viral", + "ubiquitous", + "nanomaterials", + "diameter", + "49", + "microcompartments", "hundreds", - "accurately", + "highly", "date", - "ranging", - "feature", - "540", - "substantially", - "method", - "designed", + "broadly", + "systems", + "accurately", "perform", - "960", - "diameter", + "components", "generated", - "moving", - "used", - "highly", - "functions", - "icosahedral", - "beyond", - "3", - "limited", - "observed", - "bounded", - "design", - "protein", - "strict", + "substantially", + "despite", + "developed", + "recent", + "kilodaltons", "pseudosymmetric", "pseudosymmetry", - "progress", - "designing", - "complexity", - "recent", - "symmetry", - "nanomaterials", - "96", - "broadens", "subunits", "variety", - "biological", - "size", - "specialized", - "computationally", - "computational", - "71", - "broadly", - "microcompartments", - "ubiquitous", - "inspired", - "systems", - "developed", + "assemblies", "create", - "capsids", - "new" + "icosahedral", + "method", + "containing", + "computational", + "96", + "discrete" ], "release_date":"2024-12-18", "publication":"\"Hierarchical design of pseudosymmetric protein nanocages\", Nature", @@ -971094,22 +975527,22 @@ "sim":449.0, "partner":"9dne" }, - { - "sim":356.0, - "partner":"8far" - }, { "sim":366.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":366.0, - "partner":"8cus" + "partner":"8cut" }, { "sim":364.0, "partner":"8cwz" }, + { + "sim":356.0, + "partner":"8far" + }, { "sim":329.0, "partner":"6xh5" @@ -971117,48 +975550,56 @@ ], "seq_thr_sim_natural":[ { - "sim":385.0, - "partner":"9ck7" + "sim":409.0, + "partner":"8e01" }, { - "sim":385.0, - "partner":"9cj7" + "sim":387.0, + "partner":"1wa3" }, { - "sim":385.0, - "partner":"9ck8" + "sim":392.0, + "partner":"1vlw" + }, + { + "sim":398.0, + "partner":"5kp9" + }, + { + "sim":397.0, + "partner":"8a8n" }, { "sim":391.0, - "partner":"8jgc" + "partner":"7b3y" }, { - "sim":387.0, - "partner":"1wa3" + "sim":391.0, + "partner":"8jgc" }, { - "sim":392.0, - "partner":"1vlw" + "sim":391.0, + "partner":"9fo3" }, { - "sim":409.0, - "partner":"8e01" + "sim":391.0, + "partner":"8jga" }, { - "sim":383.0, - "partner":"9cj8" + "sim":391.0, + "partner":"8ed3" }, { - "sim":383.0, - "partner":"8ejh" + "sim":385.0, + "partner":"9cj7" }, { - "sim":383.0, - "partner":"8ejd" + "sim":385.0, + "partner":"9ck7" }, { - "sim":383.0, - "partner":"8eji" + "sim":385.0, + "partner":"9ck8" }, { "sim":383.0, @@ -971166,11 +975607,11 @@ }, { "sim":383.0, - "partner":"8vcv" + "partner":"8ejd" }, { "sim":383.0, - "partner":"8ejf" + "partner":"8eji" }, { "sim":383.0, @@ -971178,55 +975619,43 @@ }, { "sim":383.0, - "partner":"8ve8" + "partner":"8ejf" }, { "sim":383.0, - "partner":"7sgd" + "partner":"8vcv" }, { "sim":383.0, - "partner":"7sge" + "partner":"9cj8" }, { "sim":383.0, - "partner":"7sgf" - }, - { - "sim":398.0, - "partner":"5kp9" - }, - { - "sim":397.0, - "partner":"8a8n" - }, - { - "sim":391.0, - "partner":"7b3y" + "partner":"8ve8" }, { - "sim":391.0, - "partner":"8jga" + "sim":383.0, + "partner":"8ejh" }, { - "sim":391.0, - "partner":"9fo3" + "sim":383.0, + "partner":"7sgd" }, { - "sim":377.0, - "partner":"8tvb" + "sim":383.0, + "partner":"7sge" }, { - "sim":391.0, - "partner":"8ed3" + "sim":383.0, + "partner":"7sgf" }, { "sim":381.0, "partner":"6p6f" }, { - "sim":113.0, - "partner":"3vcr" + "sim":377.0, + "partner":"8tvb" }, { "sim":111.0, @@ -971236,6 +975665,10 @@ "sim":111.0, "partner":"2yw4" }, + { + "sim":113.0, + "partner":"3vcr" + }, { "sim":110.0, "partner":"2v81" @@ -971244,14 +975677,6 @@ "sim":110.0, "partner":"2v82" }, - { - "sim":108.0, - "partner":"5im5" - }, - { - "sim":108.0, - "partner":"1vhc" - }, { "sim":106.0, "partner":"6ovi" @@ -971262,11 +975687,11 @@ }, { "sim":101.0, - "partner":"8di1" + "partner":"4qcc" }, { "sim":101.0, - "partner":"4qcc" + "partner":"8di1" }, { "sim":100.0, @@ -971296,10 +975721,22 @@ "sim":96.0, "partner":"1fwr" }, + { + "sim":108.0, + "partner":"5im5" + }, + { + "sim":108.0, + "partner":"1vhc" + }, { "sim":93.0, "partner":"1mxs" }, + { + "sim":90.0, + "partner":"4bk9" + }, { "sim":86.0, "partner":"5xse" @@ -971307,10 +975744,6 @@ { "sim":86.0, "partner":"5xsf" - }, - { - "sim":90.0, - "partner":"4bk9" } ], "struct_thr_sim_designed":[ @@ -971446,90 +975879,90 @@ ], "subtitle":"Pseudosymmetric protein nanocage gi9-f7 (local refinement)", "tags":[ - "seattle structural genomics center for infectious disease", - "viral protein", "pseudosymmetric protein nanocages", - "structural genomics", + "seattle structural genomics center for infectious disease", "fusion protein", - "ssgcid" + "viral protein", + "ssgcid", + "structural genomics" ], "keywords":[ + "designed", + "960", + "designing", + "limited", + "symmetry", + "design", + "megadaltons", "work", + "240", + "observed", + "used", + "feature", + "ranging", + "progress", + "computationally", + "heterooligomeric", + "3", + "inspired", + "moving", + "biological", + "accessible", + "nm", + "hierarchical", + "capsids", + "specialized", "nanocages", + "new", + "beyond", + "540", + "functions", + "bounded", + "complexity", "largest", - "reliance", - "containing", - "discrete", - "hierarchical", + "protein", + "broadens", "architectures", - "heterooligomeric", - "49", - "megadaltons", - "kilodaltons", - "despite", - "bacterial", - "nm", + "strict", "proteins", - "viral", - "large", - "240", - "accessible", - "components", + "reliance", "remarkable", - "assemblies", + "large", + "71", + "size", + "bacterial", + "viral", + "ubiquitous", + "nanomaterials", + "diameter", + "49", + "microcompartments", "hundreds", - "accurately", + "highly", "date", - "ranging", - "feature", - "540", - "substantially", - "method", - "designed", + "broadly", + "systems", + "accurately", "perform", - "960", - "diameter", + "components", "generated", - "moving", - "used", - "highly", - "functions", - "icosahedral", - "beyond", - "3", - "limited", - "observed", - "bounded", - "design", - "protein", - "strict", + "substantially", + "despite", + "developed", + "recent", + "kilodaltons", "pseudosymmetric", "pseudosymmetry", - "progress", - "designing", - "complexity", - "recent", - "symmetry", - "nanomaterials", - "96", - "broadens", "subunits", "variety", - "biological", - "size", - "specialized", - "computationally", - "computational", - "71", - "broadly", - "microcompartments", - "ubiquitous", - "inspired", - "systems", - "developed", + "assemblies", "create", - "capsids", - "new" + "icosahedral", + "method", + "containing", + "computational", + "96", + "discrete" ], "release_date":"2024-12-18", "publication":"\"Hierarchical design of pseudosymmetric protein nanocages\", Nature", @@ -971566,11 +975999,11 @@ }, { "sim":366.0, - "partner":"8cut" + "partner":"8cus" }, { "sim":366.0, - "partner":"8cus" + "partner":"8cut" }, { "sim":364.0, @@ -971587,40 +976020,48 @@ ], "seq_thr_sim_natural":[ { - "sim":385.0, - "partner":"9ck7" + "sim":409.0, + "partner":"8e01" }, { - "sim":385.0, - "partner":"9cj7" + "sim":398.0, + "partner":"5kp9" }, { - "sim":385.0, - "partner":"9ck8" + "sim":397.0, + "partner":"8a8n" + }, + { + "sim":392.0, + "partner":"1vlw" }, { "sim":391.0, - "partner":"8jgc" + "partner":"8ed3" }, { - "sim":387.0, - "partner":"1wa3" + "sim":391.0, + "partner":"9fo3" }, { - "sim":392.0, - "partner":"1vlw" + "sim":391.0, + "partner":"7b3y" }, { - "sim":409.0, - "partner":"8e01" + "sim":391.0, + "partner":"8jga" }, { - "sim":383.0, - "partner":"9cj8" + "sim":391.0, + "partner":"8jgc" + }, + { + "sim":387.0, + "partner":"1wa3" }, { "sim":383.0, - "partner":"8ejh" + "partner":"8tyc" }, { "sim":383.0, @@ -971632,19 +976073,19 @@ }, { "sim":383.0, - "partner":"8tyc" + "partner":"8tye" }, { "sim":383.0, - "partner":"8vcv" + "partner":"8ejf" }, { "sim":383.0, - "partner":"8ejf" + "partner":"8vcv" }, { "sim":383.0, - "partner":"8tye" + "partner":"9cj8" }, { "sim":383.0, @@ -971652,51 +976093,43 @@ }, { "sim":383.0, - "partner":"7sgd" + "partner":"8ejh" }, { - "sim":383.0, - "partner":"7sge" + "sim":385.0, + "partner":"9cj7" }, { - "sim":383.0, - "partner":"7sgf" + "sim":385.0, + "partner":"9ck7" }, { - "sim":398.0, - "partner":"5kp9" + "sim":385.0, + "partner":"9ck8" }, { - "sim":397.0, - "partner":"8a8n" + "sim":383.0, + "partner":"7sgd" }, { - "sim":391.0, - "partner":"7b3y" + "sim":383.0, + "partner":"7sge" }, { - "sim":391.0, - "partner":"8jga" + "sim":383.0, + "partner":"7sgf" }, { - "sim":391.0, - "partner":"9fo3" + "sim":381.0, + "partner":"6p6f" }, { "sim":377.0, "partner":"8tvb" }, { - "sim":391.0, - "partner":"8ed3" - }, - { - "sim":381.0, - "partner":"6p6f" - }, - { - "sim":113.0, - "partner":"3vcr" + "sim":106.0, + "partner":"6ovi" }, { "sim":111.0, @@ -971706,6 +976139,10 @@ "sim":111.0, "partner":"2yw4" }, + { + "sim":113.0, + "partner":"3vcr" + }, { "sim":110.0, "partner":"2v81" @@ -971714,22 +976151,6 @@ "sim":110.0, "partner":"2v82" }, - { - "sim":108.0, - "partner":"5im5" - }, - { - "sim":108.0, - "partner":"1vhc" - }, - { - "sim":106.0, - "partner":"6ovi" - }, - { - "sim":102.0, - "partner":"4e38" - }, { "sim":101.0, "partner":"8di1" @@ -971738,6 +976159,10 @@ "sim":101.0, "partner":"4qcc" }, + { + "sim":102.0, + "partner":"4e38" + }, { "sim":100.0, "partner":"1eun" @@ -971766,21 +976191,29 @@ "sim":96.0, "partner":"1fwr" }, + { + "sim":90.0, + "partner":"4bk9" + }, + { + "sim":108.0, + "partner":"1vhc" + }, { "sim":93.0, "partner":"1mxs" }, { - "sim":86.0, - "partner":"5xse" + "sim":108.0, + "partner":"5im5" }, { "sim":86.0, "partner":"5xsf" }, { - "sim":90.0, - "partner":"4bk9" + "sim":86.0, + "partner":"5xse" } ], "struct_thr_sim_designed":[ @@ -971882,13 +976315,13 @@ "classification_suggested_reason":[ ], - "subtitle":"A darpin fused to the 1tel crystallization chaperone via a direct helical fusion", + "subtitle":"Crystal structure of a darpin fused to the 1tel crystallization chaperone via a direct helical fusion in a 2-fold crystal form", "tags":[ + "darpin", "designed ankyrin repeat protein", - "etv6", + "protein binding", "telsam", - "darpin", - "protein binding" + "etv6" ], "keywords":[ "description", @@ -972017,7 +976450,7 @@ "surname":"Lee" }, { - "forename":"J.H.", + "forename":"J.", "surname":"Chun" }, { @@ -972034,7 +976467,7 @@ }, { "forename":"M.", - "surname":"Gloegl" + "surname":"Glogl" }, { "forename":"C.", @@ -972063,115 +976496,115 @@ ], "subtitle":"Computationally designed bifaceted protein nanomaterial pd5-14", "tags":[ - "4 component", - "penton", + "nanomaterial", "de novo protein", + "4 component", "bifaceted", - "nanomaterial" + "penton" ], "keywords":[ - "require", - "precludes", - "date", - "strategy", - "controllably", - "morphology", - "designed", - "generated", + "structural", + "additional", "methods", - "target", - "obtain", - "altered", - "designing", + "minibinders", + "heterooligomeric", + "group", + "subunit", + "extensions", + "addressable", + "dihedral", + "strategy", "docking", - "diversity", - "broadly", - "however", - "building", - "colocalization", - "distinctly", - "general", - "architectures", - "receptors", - "de", - "nanoparticles", - "variants", - "point", - "interface", - "used", - "initial", - "ability", + "protein", + "symmetrically", "sides", + "general", "centers", - "structures", - "pseudosymmetric", - "dihedral", - "assembly", - "size", - "exhibit", - "additional", - "functionalization", - "nearly", - "achieved", - "polystyrene", - "considerable", - "minibinders", - "microparticles", - "group", + "novo", + "controllably", + "accurately", + "two", + "recent", + "related", + "applications", "asymmetric", - "method", + "initial", + "however", "limits", - "useful", - "functions", - "anisotropic", - "advances", - "specific", + "nearly", "faces", + "enabled", + "specific", + "functionalization", + "functions", + "led", + "useful", + "populations", + "approach", "blocks", - "design", - "addressable", - "symmetrically", - "applications", - "progress", - "symmetry", - "recent", - "describe", - "nanomaterials", - "colocalizing", + "achieved", + "occupying", + "size", + "interface", + "tunable", + "15", "subunits", + "precludes", + "moieties", + "computational", "property", - "structural", - "led", - "heterooligomeric", - "one", - "approach", - "accurately", - "novo", - "populations", - "extensions", + "designing", + "advances", + "colocalizing", + "exhibit", + "design", + "symmetry", "bifaceted", - "subunit", - "two", - "coated", + "used", + "nanoparticles", + "distinctly", + "polystyrene", + "anisotropic", + "environment", + "altered", + "assembly", + "diversity", + "point", "precisely", - "occupying", - "protein", - "strict", - "15", + "architectures", + "microparticles", + "nanomaterials", + "ability", + "broadly", + "building", "identical", - "environment", + "describe", + "method", + "obtain", + "designed", + "coated", + "require", + "one", + "receptors", + "variants", + "structures", + "de", + "progress", + "target", + "strict", + "considerable", + "date", "distinct", - "computational", - "enabled", - "tunable", - "moieties", - "related" + "generated", + "morphology", + "pseudosymmetric", + "colocalization" ], "release_date":"2024-10-30", "publication":"\"Computational design of bifaceted protein nanomaterials with tailorable properties\", Biorxiv", "publication_ref":{ "DOI":"10.1101\/2024.10.18.619149", - "PubMed":"", + 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}, - { - "sim":108.0, - "partner":"7a8m" - }, - { - "sim":108.0, - "partner":"7a83" - }, - { - "sim":108.0, - "partner":"7a84" - }, { "sim":108.0, "partner":"6uhj" @@ -975086,22 +980511,6 @@ "sim":108.0, "partner":"6t90" }, - { - "sim":108.0, - "partner":"8j1e" - }, - { - "sim":108.0, - "partner":"8j0j" - }, - { - "sim":108.0, - "partner":"8gw6" - }, - { - "sim":108.0, - "partner":"8gw7" - }, { "sim":108.0, "partner":"7sun" @@ -975110,46 +980519,18 @@ "sim":108.0, "partner":"4anj" }, - { - "sim":108.0, - "partner":"6rmg" - }, - { - "sim":108.0, - "partner":"6r4o" - }, - { - "sim":108.0, - "partner":"6r4p" - }, - { - "sim":108.0, - "partner":"6r3q" - }, - { - "sim":107.0, - "partner":"2q6p" - }, - { - "sim":107.0, - "partner":"1jc0" - }, { "sim":107.0, "partner":"6xzf" }, { "sim":107.0, - "partner":"7pca" + "partner":"1jc0" }, { "sim":107.0, "partner":"1jc1" }, - { - "sim":107.0, - "partner":"7pcz" - }, { "sim":107.0, "partner":"1rm9" @@ -975162,17 +980543,13 @@ "sim":107.0, "partner":"8jlt" }, - { - "sim":107.0, - "partner":"7yv3" - }, { "sim":107.0, "partner":"8jlu" }, { "sim":107.0, - "partner":"7yv5" + "partner":"8jlm" }, { "sim":107.0, @@ -975180,36 +980557,16 @@ }, { "sim":107.0, - "partner":"8jlm" - }, - { - "sim":107.0, - "partner":"1kyp" + "partner":"2q6p" }, { "sim":107.0, "partner":"5dpj" }, - { - "sim":107.0, - "partner":"2fwq" - }, - { - "sim":107.0, - "partner":"1kyr" - }, - { - "sim":107.0, - "partner":"1kys" - }, { "sim":107.0, "partner":"4eul" }, - { - "sim":107.0, - "partner":"7ugs" - }, { "sim":107.0, "partner":"2emd" @@ -975228,11 +980585,11 @@ }, { "sim":107.0, - "partner":"2emn" + "partner":"6qq8" }, { "sim":107.0, - "partner":"6qq8" + "partner":"2emn" }, { "sim":107.0, @@ -975278,22 +980635,6 @@ "sim":107.0, "partner":"3ogo" }, - { - "sim":107.0, - "partner":"3cd9" - }, - { - "sim":107.0, - "partner":"3cb9" - }, - { - "sim":107.0, - "partner":"3cd1" - }, - { - "sim":107.0, - "partner":"3cbe" - }, { "sim":107.0, "partner":"2y0g" @@ -975318,18 +980659,10 @@ "sim":107.0, "partner":"6uhk" }, - { - "sim":107.0, - "partner":"7xhb" - }, { "sim":107.0, "partner":"7rfp" }, - { - "sim":107.0, - "partner":"7eeb" - }, { "sim":107.0, "partner":"7ks0" @@ -975350,30 +980683,6 @@ "sim":107.0, "partner":"8wg4" }, - { - "sim":107.0, - "partner":"8t1f" - }, - { - "sim":107.0, - "partner":"8t1b" - }, - { - "sim":107.0, - "partner":"8t1c" - }, - { - "sim":107.0, - "partner":"8t1d" - }, - { - "sim":107.0, - "partner":"8t1e" - }, - { - "sim":107.0, - "partner":"8jf7" - }, { "sim":107.0, "partner":"7eyq" @@ -975382,37 +980691,25 @@ "sim":107.0, "partner":"7wji" }, - { - "sim":106.0, - "partner":"7pd0" - }, { "sim":106.0, "partner":"8bvg" }, - { - "sim":106.0, - "partner":"2g6e" - }, { "sim":106.0, "partner":"1emc" }, - { - "sim":106.0, - "partner":"1yhg" - }, { "sim":106.0, "partner":"3la1" }, { "sim":106.0, - "partner":"1eme" + "partner":"1yhi" }, { "sim":106.0, - "partner":"1yhi" + "partner":"1eme" }, { "sim":106.0, @@ -975420,19 +980717,19 @@ }, { "sim":106.0, - "partner":"1emk" + "partner":"6dq0" }, { "sim":106.0, - "partner":"1eml" + "partner":"5dpg" }, { "sim":106.0, - "partner":"6dq0" + "partner":"1emk" }, { "sim":106.0, - "partner":"5dpg" + "partner":"1eml" }, { "sim":106.0, @@ -975450,10 +980747,6 @@ "sim":106.0, "partner":"3i19" }, - { - "sim":106.0, - "partner":"5ma4" - }, { "sim":106.0, "partner":"5ma5" @@ -975488,31 +980781,27 @@ }, { "sim":106.0, - "partner":"7km4" - }, - { - "sim":106.0, - "partner":"4lqu" + "partner":"5ma4" }, { "sim":106.0, - "partner":"5jzl" + "partner":"8et3" }, { "sim":106.0, - "partner":"8et3" + "partner":"8sok" }, { "sim":106.0, - "partner":"7sqy" + "partner":"8b6s" }, { "sim":106.0, - "partner":"8sok" + "partner":"8u4r" }, { "sim":106.0, - "partner":"8b6s" + "partner":"8u4s" }, { "sim":106.0, @@ -975534,14 +980823,6 @@ "sim":106.0, "partner":"8u4q" }, - { - "sim":106.0, - "partner":"8u4r" - }, - { - "sim":106.0, - "partner":"8u4s" - }, { "sim":106.0, "partner":"7ydq" @@ -975574,10 +980855,6 @@ "sim":106.0, "partner":"4p7h" }, - { - "sim":106.0, - "partner":"7zji" - }, { "sim":106.0, "partner":"7zjd" @@ -975594,6 +980871,10 @@ "sim":106.0, "partner":"7zjh" }, + { + "sim":106.0, + "partner":"7zji" + }, { "sim":106.0, "partner":"8soj" @@ -975646,10 +980927,6 @@ "sim":105.0, "partner":"4orn" }, - { - "sim":105.0, - "partner":"4lqt" - }, { "sim":105.0, "partner":"9f33" @@ -975694,10 +980971,6 @@ "sim":104.0, "partner":"4kw8" }, - { - "sim":104.0, - "partner":"8dhy" - }, { "sim":104.0, "partner":"4kw9" @@ -975706,10 +980979,6 @@ "sim":104.0, "partner":"4kw4" }, - { - "sim":104.0, - "partner":"6krg" - }, { "sim":104.0, "partner":"3st2" @@ -975726,665 +980995,309 @@ "sim":104.0, "partner":"4en1" }, - { - "sim":506.0, - "partner":"8y6h" - }, - { - "sim":506.0, - "partner":"8y6i" - }, { "sim":103.0, "partner":"5hzo" }, { "sim":103.0, - "partner":"1qyq" + "partner":"8pko" }, { - "sim":103.0, - "partner":"1qyo" + "sim":102.0, + "partner":"6sm0" }, { - "sim":103.0, - "partner":"1yhh" + "sim":102.0, + "partner":"3lva" }, { - "sim":103.0, - "partner":"4j88" + "sim":102.0, + "partner":"1rmo" }, { - "sim":103.0, - "partner":"4j89" + "sim":102.0, + "partner":"5dqm" }, { - "sim":103.0, - "partner":"8kex" + "sim":102.0, + "partner":"5dqb" }, { - "sim":103.0, - "partner":"8k4s" + "sim":102.0, + "partner":"5drf" }, { - "sim":103.0, - "partner":"8j7m" + "sim":102.0, + "partner":"5drg" }, { - "sim":103.0, - "partner":"7x5v" + "sim":101.0, + "partner":"4ka9" }, { - "sim":103.0, - "partner":"8j7h" + "sim":100.0, + "partner":"5mse" }, { - "sim":103.0, - "partner":"7xj0" + "sim":100.0, + "partner":"4gf6" }, { - "sim":103.0, - "partner":"7xj1" + "sim":100.0, + "partner":"4u2v" }, { - "sim":103.0, - "partner":"7xj2" + "sim":99.0, + "partner":"7lg4" }, { - "sim":103.0, - "partner":"7xj3" + "sim":99.0, + "partner":"5ktg" }, { - "sim":103.0, - "partner":"8j6m" + "sim":99.0, + "partner":"4bdu" }, { - "sim":103.0, - "partner":"8j6o" + "sim":98.0, + "partner":"1yfp" }, { - "sim":103.0, - "partner":"8jqr" + "sim":98.0, + "partner":"6mb2" }, { - "sim":103.0, - "partner":"8x94" + "sim":98.0, + "partner":"2awm" }, { - "sim":103.0, - "partner":"8jvi" + "sim":98.0, + "partner":"5aqb" }, { - "sim":103.0, - "partner":"8ju5" + "sim":98.0, + "partner":"3vht" }, { - "sim":103.0, - "partner":"8jvj" + "sim":98.0, + "partner":"4w6n" }, { - "sim":103.0, - "partner":"8ju6" + "sim":98.0, + "partner":"4w6o" }, { - "sim":103.0, - "partner":"8pko" + "sim":98.0, + "partner":"4w6j" }, { - "sim":103.0, - "partner":"7xmf" + "sim":98.0, + "partner":"4w6k" }, { - "sim":103.0, - "partner":"7xmg" + "sim":98.0, + "partner":"4w6l" }, { - "sim":103.0, - "partner":"7xm9" + "sim":98.0, + "partner":"4w6m" }, { - "sim":102.0, - "partner":"6sm0" + "sim":98.0, + "partner":"4lw5" }, { - "sim":102.0, - "partner":"5wwk" + "sim":98.0, + "partner":"8bav" }, { - "sim":484.0, - "partner":"7z7p" + "sim":98.0, + "partner":"8ban" }, { - "sim":484.0, - "partner":"7z7o" + "sim":98.0, + "partner":"8bbj" }, { - "sim":102.0, - "partner":"1rmo" + "sim":98.0, + "partner":"4z4m" }, { - "sim":102.0, - "partner":"3lva" + "sim":98.0, + "partner":"3ai4" }, { - "sim":102.0, - "partner":"5dqm" + "sim":98.0, + "partner":"4z4k" }, { - "sim":102.0, - "partner":"5dqb" + "sim":98.0, + "partner":"3ai5" }, { - "sim":102.0, - "partner":"5drf" + "sim":98.0, + "partner":"4jrb" }, { - "sim":102.0, - "partner":"5drg" + "sim":98.0, + "partner":"5fgu" }, { - "sim":102.0, - "partner":"4xgy" + "sim":98.0, + "partner":"4pa0" }, { - "sim":101.0, - "partner":"6jgj" + "sim":97.0, + "partner":"2awj" }, { - "sim":101.0, - "partner":"7e53" + "sim":97.0, + "partner":"2awk" }, { - "sim":101.0, - "partner":"4ka9" + "sim":97.0, + "partner":"2awl" }, { - "sim":101.0, - "partner":"1kp5" + "sim":97.0, + "partner":"1qyf" }, { - "sim":502.0, - "partner":"5ltp" + "sim":97.0, + "partner":"1qxt" }, { - "sim":502.0, - "partner":"5ltr" + "sim":97.0, + "partner":"4l1i" }, { - "sim":101.0, - "partner":"3wck" + "sim":97.0, + "partner":"4l12" }, { - "sim":101.0, - "partner":"7xha" + "sim":97.0, + "partner":"4l13" }, { - "sim":101.0, - "partner":"4xbi" + "sim":97.0, + "partner":"4rtc" }, { - "sim":100.0, - "partner":"4p1q" + "sim":97.0, + "partner":"6wrf" }, { - "sim":100.0, - "partner":"6kkz" + "sim":97.0, + "partner":"6wsg" }, { - "sim":100.0, - "partner":"6kl0" + "sim":97.0, + "partner":"6mks" }, { - "sim":100.0, - "partner":"2qz0" + "sim":97.0, + "partner":"8x9p" }, { - "sim":100.0, - "partner":"6jgh" + "sim":96.0, + "partner":"1rrx" }, { - "sim":100.0, - "partner":"6jgi" + "sim":96.0, + "partner":"1qy3" }, { - "sim":100.0, - "partner":"3gj1" + "sim":96.0, + "partner":"4w6s" }, { - "sim":100.0, - "partner":"6kl1" + "sim":96.0, + "partner":"4w75" }, { - "sim":100.0, - "partner":"3gj2" + "sim":96.0, + "partner":"4w76" }, { - "sim":100.0, - "partner":"7ugt" + "sim":96.0, + "partner":"4w77" }, { - "sim":479.0, - "partner":"7z7q" + "sim":96.0, + "partner":"4w6c" }, { - "sim":100.0, - "partner":"6b9c" + "sim":96.0, + "partner":"4w6f" }, { - "sim":100.0, - "partner":"6oa8" + "sim":96.0, + "partner":"4w7a" }, { - "sim":100.0, - "partner":"7amf" + "sim":96.0, + "partner":"4w7c" }, { - "sim":100.0, - "partner":"7amb" + "sim":96.0, + "partner":"4w7r" }, { - "sim":100.0, - "partner":"5mse" + "sim":96.0, + "partner":"4w7d" }, { - "sim":100.0, - "partner":"4jfg" + "sim":96.0, + "partner":"4w7e" }, { - "sim":100.0, - "partner":"4gf6" + "sim":96.0, + "partner":"4w7f" }, { - "sim":100.0, - "partner":"4u2v" + "sim":96.0, + "partner":"4w6d" }, { - "sim":99.0, - "partner":"5bt0" + "sim":96.0, + "partner":"4w6g" }, { - "sim":99.0, - "partner":"8bxp" + "sim":96.0, + "partner":"4w6h" }, { - "sim":99.0, - "partner":"8g4e" + "sim":96.0, + "partner":"4w6i" }, { - "sim":99.0, - "partner":"6nhv" + "sim":95.0, + "partner":"1oxd" }, { - "sim":99.0, - "partner":"7lg4" + "sim":95.0, + "partner":"1oxe" }, { - "sim":99.0, - "partner":"4bdu" + "sim":95.0, + "partner":"4w69" }, { - "sim":99.0, - "partner":"5ktg" + "sim":95.0, + "partner":"4w6a" }, { - "sim":99.0, - "partner":"5wts" + "sim":95.0, + "partner":"4w6p" }, { - "sim":99.0, - "partner":"8gz3" - }, - { - "sim":99.0, - "partner":"5wua" - }, - { - "sim":99.0, - "partner":"7ewr" - }, - { - "sim":99.0, - "partner":"7ewp" - }, - { - "sim":98.0, - "partner":"1yfp" - }, - { - "sim":98.0, - "partner":"5ni3" - }, - { - "sim":98.0, - "partner":"6mb2" - }, - { - "sim":98.0, - "partner":"5btt" - }, - { - "sim":98.0, - "partner":"2awm" - }, - { - "sim":98.0, - "partner":"2qrf" - }, - { - "sim":98.0, - "partner":"5nhn" - }, - { - "sim":98.0, - "partner":"5aqb" - }, - { - "sim":98.0, - "partner":"3vht" - }, - { - "sim":98.0, - "partner":"4w6m" - }, - { - "sim":98.0, - "partner":"4w6n" - }, - { - "sim":98.0, - "partner":"4w6o" - }, - { - "sim":98.0, - "partner":"4w6j" - }, - { - "sim":98.0, - "partner":"4w6k" - }, - { - "sim":98.0, - "partner":"4w6l" - }, - { - "sim":98.0, - "partner":"4b30" - }, - { - "sim":98.0, - 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"sim":97.0, - "partner":"4l1i" - }, - { - "sim":97.0, - "partner":"4l12" - }, - { - "sim":97.0, - "partner":"4l13" - }, - { - "sim":97.0, - "partner":"6b7t" - }, - { - "sim":97.0, - "partner":"4rtc" - }, - { - "sim":97.0, - "partner":"6ofo" - }, - { - "sim":97.0, - "partner":"2wiq" - }, - { - "sim":97.0, - "partner":"2wis" - }, - { - "sim":97.0, - "partner":"6wrf" - }, - { - "sim":97.0, - "partner":"6wsg" - }, - { - "sim":97.0, - "partner":"6mks" - }, - { - "sim":97.0, - "partner":"8x9p" - }, - { - "sim":96.0, - "partner":"1rrx" - }, - { - "sim":96.0, - "partner":"1qy3" - }, - { - "sim":96.0, - "partner":"4w6s" - }, - { - "sim":96.0, - "partner":"4w75" - }, - { - "sim":96.0, - "partner":"4w76" - }, - { - "sim":96.0, - "partner":"4w77" - }, - { - "sim":96.0, - "partner":"4w6c" - }, - { - "sim":96.0, - "partner":"4w6f" - }, - { - "sim":96.0, - "partner":"4w7a" - }, - { - "sim":96.0, - "partner":"4w7c" - }, - { - "sim":96.0, - "partner":"4w7r" - }, - { - "sim":96.0, - "partner":"4w7d" - }, - { - "sim":96.0, - "partner":"4w7e" - }, - { - "sim":96.0, - "partner":"4w7f" - }, - { - "sim":96.0, - "partner":"8c1x" - }, - { - "sim":96.0, - "partner":"8b2y" - }, - { - "sim":96.0, - "partner":"4w6b" - }, - { - "sim":96.0, - "partner":"4w6d" - }, - { - "sim":96.0, - "partner":"4w6g" - }, - { - "sim":96.0, - "partner":"4w6h" - }, - { - "sim":96.0, - "partner":"4w6i" - }, - { - "sim":96.0, - "partner":"3gl4" - }, - { - "sim":96.0, - "partner":"3gb3" - }, - { - "sim":96.0, - "partner":"8i4o" - }, - { - "sim":96.0, - "partner":"4zbl" - }, - { - "sim":96.0, - "partner":"3o77" - }, - { - "sim":96.0, - "partner":"3o78" - }, - { - "sim":95.0, - "partner":"1oxd" - }, - { - "sim":95.0, - "partner":"1oxe" - }, - { - "sim":95.0, - "partner":"4w69" - }, - { - "sim":95.0, - "partner":"4w6a" - }, - { - "sim":95.0, - "partner":"4w6p" + "sim":95.0, + "partner":"6l02" }, { "sim":95.0, - "partner":"6l02" + "partner":"8xh0" }, { "sim":95.0, @@ -976394,18 +981307,10 @@ "sim":95.0, "partner":"8xh2" }, - { - "sim":95.0, - "partner":"8xh0" - }, { "sim":95.0, "partner":"4n3d" }, - { - "sim":95.0, - "partner":"8uqq" - }, { "sim":94.0, "partner":"3ako" @@ -976414,14 +981319,6 @@ "sim":94.0, "partner":"1oxf" }, - { - "sim":94.0, - "partner":"3ufz" - }, - { - "sim":94.0, - "partner":"3ug0" - }, { "sim":94.0, "partner":"4w6t" @@ -976430,94 +981327,6 @@ "sim":94.0, "partner":"4w6u" }, - { - "sim":94.0, - "partner":"4he4" - }, - { - "sim":94.0, - "partner":"6wve" - }, - { - "sim":94.0, - "partner":"7y96" - }, - { - "sim":94.0, - "partner":"6m63" - }, - { - "sim":94.0, - "partner":"6wv3" - }, - { - "sim":94.0, - "partner":"6wv4" - }, - { - "sim":94.0, - "partner":"6wv5" - }, - { - "sim":94.0, - "partner":"6wv6" - }, - { - "sim":94.0, - "partner":"6wv7" - }, - { - "sim":94.0, - "partner":"6wvh" - }, - { - "sim":94.0, - "partner":"6wvi" - }, - { - "sim":94.0, - "partner":"6wv8" - }, - { - "sim":94.0, - "partner":"6wv9" - }, - { - "sim":94.0, - "partner":"6wva" - }, - { - "sim":94.0, - "partner":"6wvb" - }, - { - "sim":94.0, - "partner":"6wvd" - }, - { - "sim":94.0, - "partner":"6wvg" - }, - { - "sim":94.0, - "partner":"6efr" - }, - { - "sim":94.0, - "partner":"6gel" - }, - { - "sim":94.0, - "partner":"6gez" - }, - { - "sim":94.0, - "partner":"6uru" - }, - { - "sim":93.0, - "partner":"5dy6" - }, { "sim":93.0, "partner":"1cv7" @@ -976542,81 +981351,21 @@ "sim":93.0, "partner":"4w6r" }, - { - "sim":93.0, - "partner":"4zfs" - }, - { - "sim":93.0, - "partner":"5f9g" - }, { "sim":93.0, "partner":"8p6g" }, - { - "sim":93.0, - "partner":"6wvf" - }, { "sim":93.0, "partner":"6lnp" }, - { - "sim":93.0, - "partner":"8ovn" - }, - { - "sim":93.0, - "partner":"8ovo" - }, - { - "sim":93.0, - "partner":"8ovp" - }, - { - "sim":93.0, - "partner":"7s7t" - }, - { - "sim":93.0, - "partner":"7s7u" - }, - { - "sim":93.0, - "partner":"7s7v" - }, - { - "sim":93.0, - "partner":"6per" - }, - { - "sim":93.0, - "partner":"6dgv" - }, - { - "sim":93.0, - "partner":"8xb2" - }, - { - "sim":93.0, - "partner":"8xb3" - }, - { - "sim":93.0, - "partner":"8xb4" - }, - { - "sim":324.0, - "partner":"4dkm" - }, { "sim":92.0, - "partner":"1rmp" + "partner":"1rmm" }, { "sim":92.0, - "partner":"1rmm" + "partner":"1rmp" }, { "sim":92.0, @@ -976626,34 +981375,14 @@ "sim":92.0, "partner":"4rys" }, - { - "sim":92.0, - "partner":"3evp" - }, { "sim":92.0, "partner":"4ryw" }, - { - "sim":458.0, - "partner":"5ltq" - }, { "sim":92.0, "partner":"7vcm" }, - { - "sim":92.0, - "partner":"6xu4" - }, - { - "sim":92.0, - "partner":"7e9y" - }, - { - "sim":92.0, - "partner":"3osq" - }, { "sim":91.0, "partner":"6l26" @@ -976662,146 +981391,6 @@ "sim":91.0, "partner":"6l27" }, - { - "sim":91.0, - "partner":"3evr" - }, - { - "sim":91.0, - "partner":"4ik5" - }, - { - "sim":91.0, - "partner":"7st4" - }, - { - "sim":91.0, - "partner":"3sg5" - }, - { - "sim":91.0, - "partner":"3sg7" - }, - { - "sim":91.0, - "partner":"4ik8" - }, - { - "sim":91.0, - "partner":"4ik9" - }, - { - "sim":91.0, - "partner":"3wlc" - }, - { - "sim":91.0, - "partner":"3wld" - }, - { - "sim":91.0, - "partner":"4ik1" - }, - { - "sim":91.0, - "partner":"4ik3" - }, - { - "sim":91.0, - "partner":"3sg4" - }, - { - "sim":91.0, - "partner":"4ik4" - }, - { - "sim":91.0, - "partner":"3ek7" - }, - { - "sim":91.0, - "partner":"3ek8" - }, - { - "sim":91.0, - "partner":"3ekh" - }, - { - "sim":91.0, - "partner":"3ekj" - }, - { - "sim":91.0, - "partner":"3evu" - }, - { - "sim":91.0, - "partner":"3ek4" - }, - { - "sim":91.0, - "partner":"3sg2" - }, - { - "sim":91.0, - "partner":"3sg3" - }, - { - "sim":91.0, - "partner":"3sg6" - }, - { - "sim":91.0, - "partner":"3osr" - }, - { - "sim":332.0, - "partner":"4jge" - }, - { - "sim":332.0, - "partner":"4jf9" - }, - { - "sim":332.0, - "partner":"4jeo" - }, - { - "sim":90.0, - "partner":"5z6y" - }, - { - "sim":90.0, - "partner":"6ya9" - }, - { - "sim":90.0, - "partner":"6zsm" - }, - { - "sim":90.0, - "partner":"6zsn" - }, - { - "sim":90.0, - "partner":"7aug" - }, - { - "sim":90.0, - "partner":"6tv7" - }, - { - "sim":135.0, - "partner":"2g6x" - }, - { - "sim":135.0, - "partner":"2g6y" - }, - { - "sim":132.0, - "partner":"2g3o" - }, { "sim":89.0, "partner":"6quh" @@ -976814,29 +981403,13 @@ "sim":89.0, "partner":"6quj" }, - { - "sim":89.0, - "partner":"8yq4" - }, - { - "sim":261.0, - "partner":"4dkn" - }, - { - "sim":350.0, - "partner":"6mas" - }, - { - "sim":88.0, - "partner":"8j2h" - }, { "sim":88.0, "partner":"8j2l" }, { - "sim":436.0, - "partner":"8c0t" + "sim":88.0, + "partner":"8j2h" }, { "sim":87.0, @@ -976860,23 +981433,15 @@ }, { "sim":87.0, - "partner":"8qdd" - }, - { - "sim":87.0, - "partner":"8q79" + "partner":"7yao" }, { "sim":87.0, - "partner":"8qbj" - }, - { - "sim":362.0, - "partner":"7sf9" + "partner":"8j3j" }, { "sim":87.0, - "partner":"7y40" + "partner":"7yre" }, { "sim":87.0, @@ -976888,7 +981453,7 @@ }, { "sim":87.0, - "partner":"7yao" + "partner":"7y40" }, { "sim":87.0, @@ -976898,34 +981463,10 @@ "sim":87.0, "partner":"8j2k" }, - { - "sim":87.0, - "partner":"8j3j" - }, - { - "sim":87.0, - "partner":"7yre" - }, { "sim":86.0, "partner":"8bxt" }, - { - "sim":86.0, - "partner":"5yr3" - }, - { - "sim":86.0, - "partner":"6ofk" - }, - { - "sim":86.0, - "partner":"6ofm" - }, - { - "sim":86.0, - "partner":"6ofn" - }, { "sim":86.0, "partner":"5y00" @@ -976935,76 +981476,12 @@ "partner":"5y01" }, { - "sim":85.0, - "partner":"2hpw" - }, - { - "sim":85.0, - "partner":"6og8" - }, - { - "sim":85.0, - "partner":"6og9" - }, - { - "sim":85.0, - "partner":"6oga" - }, - { - "sim":85.0, - "partner":"6ogb" - }, - { - "sim":85.0, - "partner":"6ogc" - }, - { - "sim":85.0, - "partner":"6un5" - }, - { - "sim":85.0, - "partner":"6un6" - }, - { - "sim":85.0, - "partner":"6un7" - }, - { - "sim":85.0, - "partner":"7cao" - }, - { - "sim":340.0, - "partner":"6m9x" - }, - { - "sim":355.0, - "partner":"7sfa" - }, - { - "sim":84.0, - "partner":"5yr2" - }, - { - "sim":84.0, - "partner":"4zf3" - }, - { - "sim":83.0, - "partner":"3evv" - }, - { - "sim":371.0, - "partner":"4hvf" - }, - { - "sim":448.0, - "partner":"5mwc" + "sim":78.0, + "partner":"3p28" }, { "sim":78.0, - "partner":"3p28" + "partner":"6jxf" }, { "sim":78.0, @@ -977018,10 +981495,6 @@ "sim":78.0, "partner":"6j1c" }, - { - "sim":78.0, - "partner":"6jxf" - }, { "sim":78.0, "partner":"3u8p" @@ -977030,14 +981503,6 @@ "sim":78.0, "partner":"8smu" }, - { - "sim":406.0, - "partner":"6xw2" - }, - { - "sim":396.0, - "partner":"8osi" - }, { "sim":76.0, "partner":"6ofl" @@ -977065,18 +981530,6 @@ { "sim":64.0, "partner":"2g16" - }, - { - "sim":233.0, - "partner":"6m9y" - }, - { - "sim":114.0, - "partner":"2dd9" - }, - { - "sim":113.0, - "partner":"2dd7" } ], "struct_thr_sim_designed":[ @@ -977181,11 +981634,11 @@ ], "subtitle":"A darpin fused to the 3tel crystallization chaperone via a gly-gly-gly fusion", "tags":[ + "darpin", "designed ankyrin repeat protein", - "etv6", + "protein binding", "telsam", - "darpin", - "protein binding" + "etv6" ], "keywords":[ "description", @@ -977287,12 +981740,12 @@ ], "subtitle":"Vanadate-bound putative ancestral protein tyrosine phosphatase shufptp - intermediate p-loop conformation", "tags":[ - "asr", - "inhibitor", "phosphatase", + "oxidized cystine", "hydrolase", - "cso", - "oxidized cystine" + "inhibitor", + "asr", + "cso" ], "keywords":[ "description", @@ -977329,15 +981782,15 @@ "seq_thr_sim_designed":[ { "sim":302.0, - "partner":"9e9m" + "partner":"9e9n" }, { "sim":302.0, - "partner":"9e9u" + "partner":"9e9m" }, { "sim":302.0, - "partner":"9e9n" + "partner":"9e9u" } ], "seq_thr_sim_natural":[ @@ -977379,15 +981832,15 @@ }, { "sim":95.0, - "partner":"2dxp" + "partner":"2i6o" }, { "sim":95.0, - "partner":"2i6o" + "partner":"2i6p" }, { "sim":95.0, - "partner":"2i6p" + "partner":"2dxp" }, { "sim":65.0, @@ -977452,7 +981905,7 @@ ], "seq_max_sim_designed":{ "sim":302.0, - "partner":"9e9m" + "partner":"9e9n" }, "seq_max_sim_natural":{ "sim":255.0, @@ -977510,13 +981963,13 @@ ], "subtitle":"Ligand free putative ancestral protein tyrosine phosphatase shufptp - c93-cyclic sulfenamide - intermediate p-loop conformation", "tags":[ - "asr", - "inhibitor", "phosphatase", - "hydrolase", - "cso", + "oxidized cystine", "cyclic sulfenamide", - "oxidized cystine" + "hydrolase", + "inhibitor", + "asr", + "cso" ], "keywords":[ "description", @@ -977553,15 +982006,15 @@ "seq_thr_sim_designed":[ { "sim":302.0, - "partner":"9e9l" + "partner":"9e9n" }, { "sim":302.0, - "partner":"9e9u" + "partner":"9e9l" }, { "sim":302.0, - "partner":"9e9n" + "partner":"9e9u" } ], "seq_thr_sim_natural":[ @@ -977603,15 +982056,15 @@ }, { "sim":95.0, - "partner":"2dxp" + "partner":"2i6o" }, { "sim":95.0, - "partner":"2i6o" + "partner":"2i6p" }, { "sim":95.0, - "partner":"2i6p" + "partner":"2dxp" }, { "sim":65.0, @@ -977676,7 +982129,7 @@ ], "seq_max_sim_designed":{ "sim":302.0, - "partner":"9e9l" + "partner":"9e9n" }, "seq_max_sim_natural":{ "sim":255.0, @@ -977734,12 +982187,12 @@ ], "subtitle":"Ligand free putative ancestral protein tyrosine phosphatase shufptp - lowest p-loop conformation", "tags":[ - "asr", - "inhibitor", "phosphatase", + "oxidized cystine", "hydrolase", - "cso", - "oxidized cystine" + "inhibitor", + "asr", + "cso" ], "keywords":[ "description", @@ -977826,15 +982279,15 @@ }, { "sim":95.0, - "partner":"2dxp" + "partner":"2i6o" }, { "sim":95.0, - "partner":"2i6o" + "partner":"2i6p" }, { "sim":95.0, - "partner":"2i6p" + "partner":"2dxp" }, { "sim":65.0, @@ -977961,13 +982414,13 @@ ], "subtitle":"Vanadate-bound putative ancestral protein tyrosine phosphatase shufptp - highest p-loop conformation", "tags":[ - "asr", - "inhibitor", "phosphatase", - "hydrolase", - "cso", + "ocs", "oxidized cystine", - "ocs" + "hydrolase", + "inhibitor", + "asr", + "cso" ], "keywords":[ "description", @@ -978004,15 +982457,15 @@ "seq_thr_sim_designed":[ { "sim":302.0, - "partner":"9e9l" + "partner":"9e9n" }, { "sim":302.0, - "partner":"9e9m" + "partner":"9e9l" }, { "sim":302.0, - "partner":"9e9n" + "partner":"9e9m" } ], "seq_thr_sim_natural":[ @@ -978054,15 +982507,15 @@ }, { "sim":95.0, - "partner":"2dxp" + "partner":"2i6o" }, { "sim":95.0, - "partner":"2i6o" + "partner":"2i6p" }, { "sim":95.0, - "partner":"2i6p" + "partner":"2dxp" }, { "sim":65.0, @@ -978127,7 +982580,7 @@ ], "seq_max_sim_designed":{ "sim":302.0, - "partner":"9e9l" + "partner":"9e9n" }, "seq_max_sim_natural":{ "sim":255.0, @@ -978221,80 +982674,80 @@ "de novo designed protein k12" ], "keywords":[ - "enabling", - "accuracy", - "performance", - "scope", - "without", - "100", - "density", - "amino", - "proteins", - "multiple", - "approach", - "hallucination", - "report", - "de", - "novo", - "1000", - "also", - "designability", + "designed", + "form", + "heterodimers", + "need", + "offers", + "scalability", + "design", "characterized", - "attractive", "problems", - "sizes", "efficient", - "optimization", - "acids", - "designed", - "method", - "advanced", - "different", + "space", + "learning", + "backbones", + "methods", + "structures", + "de", + "hallucination", "used", + "multiple", "approaches", - "functions", - "pipelines", - "scales", - "broad", - "relaxed", - "two", - "methods", + "enabling", + "field", "experimentally", - "crystal", - "validated", - "heterodimers", - "generative", + "different", + "respect", + "scales", + "three", "application", - "set", - "retraining", - "increasingly", - "design", - "produced", - "applicability", - "structures", - "protein", - "microscopy", + "without", + "1000", "synthetic", + "sizes", + "report", + "retraining", + "machine", + "pipeline", + "also", + "functions", + "relaxed", "interactions", - "offers", - "respect", + "protein", + "maps", + "optimization", + "performance", + "designability", + "amino", + "approach", "validate", - "space", + "proteins", + "comprising", "across", - "dominating", - "three", + "accuracy", + "broad", + "produced", + "microscopy", + "validated", + "novo", "sequence", - "maps", - "scalability", - "form", - "comprising", - "backbones", - "learning", - "field", + "applicability", + "scope", + "acids", + "increasingly", + "pipelines", + "two", + "generative", + "density", + "crystal", + "attractive", "ml", - "pipeline", - "need", - "machine" + "dominating", + "100", + "method", + "set", + "advanced" ], "release_date":"2024-10-16", "publication":"\"Scalable protein design using optimization in a relaxed sequence space\", Science, 386, 439-445", @@ -978427,84 +982880,84 @@ ], "subtitle":"Efficient and scalable protein design using a relaxed sequence space", "tags":[ - "p600", - "de novo protein" + "de novo protein", + "p600" ], "keywords":[ - "enabling", - "accuracy", - "performance", - "scope", - "without", - "100", - "density", - "amino", - "proteins", - "multiple", - "approach", - "hallucination", - "report", - "de", - "novo", - "1000", - "also", - "designability", + "designed", + "form", + "heterodimers", + "need", + "offers", + "scalability", + "design", "characterized", - "attractive", "problems", - "sizes", "efficient", - "optimization", - "acids", - "designed", - "method", - "advanced", - "different", + "space", + "learning", + "backbones", + "methods", + "structures", + "de", + "hallucination", "used", + "multiple", "approaches", - "functions", - "pipelines", - "scales", - "broad", - "relaxed", - "two", - "methods", + "enabling", + "field", "experimentally", - "crystal", - "validated", - "heterodimers", - "generative", + "different", + "respect", + "scales", + "three", "application", - "set", - "retraining", - "increasingly", - "design", - "produced", - "applicability", - "structures", - "protein", - "microscopy", + "without", + "1000", "synthetic", + "sizes", + "report", + "retraining", + "machine", + "pipeline", + "also", + "functions", + "relaxed", "interactions", - "offers", - "respect", + "protein", + "maps", + "optimization", + "performance", + "designability", + "amino", + "approach", "validate", - "space", + "proteins", + "comprising", "across", - "dominating", - "three", + "accuracy", + "broad", + "produced", + "microscopy", + "validated", + "novo", "sequence", - "maps", - "scalability", - "form", - "comprising", - "backbones", - "learning", - "field", + "applicability", + "scope", + "acids", + "increasingly", + "pipelines", + "two", + "generative", + "density", + "crystal", + "attractive", "ml", - "pipeline", - "need", - "machine" + "dominating", + "100", + "method", + "set", + "advanced" ], "release_date":"2024-10-16", "publication":"\"Scalable protein design using optimization in a relaxed sequence space\", Science, 386, 439-445", @@ -978599,17 +983052,21 @@ "surname":"Korf" }, { - "forename":"F.", - "surname":"Abendroth" + "forename":"A.V.", + "surname":"Dinh-Fricke" }, { - "forename":"A.V.", - "surname":"Fricke" + "forename":"F.", + "surname":"Abendroth" }, { "forename":"A.", "surname":"Koide" }, + { + "forename":"U.", + "surname":"Linne" + }, { "forename":"M.", "surname":"Rakwalska-Bange" @@ -978619,7 +983076,7 @@ "surname":"Koide" }, { - "forename":"L.-O.", + "forename":"L.O.", "surname":"Essen" }, { @@ -978640,28 +983097,118 @@ ], "subtitle":"Complex between d-sh2 domain of abl with monobody dam27", "tags":[ - "d-protein", - "sh2 domain", - "mirror-image phage display", "complex", + "d-protein", "protein binding", - "monobody" + "monobody", + "sh2 domain", + "mirror-image phage display" ], "keywords":[ - "description", - "found" + "development", + "show", + "methods", + "complexes", + "tyrosine", + "delivery", + "make", + "folding", + "readily", + "binding", + "cells", + "demonstrate", + "composed", + "physiological", + "two", + "crystal", + "attractive", + "either", + "prepare", + "represents", + "step", + "accessible", + "particularly", + "residues", + "endogenous", + "library", + "bind", + "stability", + "combined", + "proteins", + "develop", + "achieved", + "cytoplasmic", + "size", + "use", + "small", + "consequently", + "chemical", + "future", + "nanomolar", + "leukemic", + "lysates", + "metabolic", + "lack", + "pocket", + "exhibit", + "bcr", + "selection", + "work", + "functional", + "inhibit", + "hence", + "display", + "proper", + "domain", + "possible", + "targeting", + "synthesis", + "ligation", + "cysteine", + "therapeutic", + "cell", + "chemically", + "shown", + "immunogenicity", + "monobodies", + "mode", + "unconventional", + "permeabilized", + "modality", + "developed", + "reveal", + "ligating", + "kinase", + "structures", + "synthesized", + "plasma", + "without", + "important", + "synthetic", + "determined", + "py", + "enable", + "phage", + "towards", + "high", + "activity", + "heterochiral", + "acids", + "potent", + "affinities", + "emerging" ], "release_date":"2024-12-25", - "publication":"To be published", + "publication":"\"Development of mirror-image monobodies targeting the oncogenic BCR::ABL1 kinase\", Nat Commun, 15, 10724-10724", "publication_ref":{ - "DOI":"", - "PubMed":"", + "DOI":"10.1038\/s41467-024-54901-y", + "PubMed":"39715735", "CSD":"", - "ISSN":"", + "ISSN":"2041-1723", "ASTM":"" }, - "publication_country":"", - "abstract":"No description found.", + "publication_country":"UK", + "abstract":"Mirror-image proteins, composed of D-amino acids, are an attractive therapeutic modality, as they exhibit high metabolic stability and lack immunogenicity. Development of mirror-image binding proteins is achieved through chemical synthesis of D-target proteins, phage display library selection of L-binders and chemical synthesis of (mirror-image) D-binders that consequently bind the physiological L-targets. Monobodies are well-established synthetic (L-)binding proteins and their small size (~90 residues) and lack of endogenous cysteine residues make them particularly accessible to chemical synthesis. Here, we develop monobodies with nanomolar binding affinities against the D-SH2 domain of the leukemic tyrosine kinase BCR::ABL1. Two crystal structures of heterochiral monobody-SH2 complexes reveal targeting of the pY binding pocket by an unconventional binding mode. We then prepare potent D-monobodies by either ligating two chemically synthesized D-peptides or by self-assembly without ligation. Their proper folding and stability are determined and high-affinity binding to the L-target is shown. D-monobodies are protease-resistant, show long-term plasma stability, inhibit BCR::ABL1 kinase activity and bind BCR::ABL1 in cell lysates and permeabilized cells. Hence, we demonstrate that functional D-monobodies can be developed readily. Our work represents an important step towards possible future therapeutic use of D-monobodies when combined with emerging methods to enable cytoplasmic delivery of monobodies.", "crystal_structure":{ "length_a":"111.326", "length_b":"111.326", @@ -978726,502 +983273,6 @@ } ], "seq_thr_sim_natural":[ - { - "sim":153.0, - "partner":"8pr7" - }, - { - "sim":152.0, - "partner":"6c83" - }, - { - "sim":152.0, - "partner":"6cpg" - }, - { - "sim":152.0, - "partner":"8sso" - }, - { - "sim":151.0, - "partner":"5mtj" - }, - { - "sim":151.0, - "partner":"6zzd" - }, - { - "sim":207.0, - "partner":"5dc9" - }, - { - "sim":207.0, - "partner":"5dc4" - }, - { - "sim":150.0, - "partner":"5e95" - }, - { - "sim":149.0, - "partner":"6zzc" - }, - { - "sim":149.0, - "partner":"6bqo" - }, - { - "sim":149.0, - "partner":"5kvm" - }, - { - "sim":149.0, - "partner":"5n7e" - }, - { - "sim":148.0, - "partner":"6byn" - }, - { - "sim":147.0, - "partner":"6sm5" - }, - { - "sim":147.0, - "partner":"4je4" - }, - { - "sim":147.0, - 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}, - { - "sim":123.0, - "partner":"6d0n" - }, - { - "sim":123.0, - "partner":"3csg" - }, - { - "sim":121.0, - "partner":"6d0j" - }, - { - "sim":121.0, - "partner":"6d0k" - }, - { - "sim":121.0, - "partner":"9cqj" - }, - { - "sim":121.0, - "partner":"4jmh" - }, - { - "sim":120.0, - "partner":"7mh6" - }, - { - "sim":120.0, - "partner":"8vxu" - }, - { - "sim":119.0, - "partner":"7mgx" - }, - { - "sim":119.0, - "partner":"7t00" - }, - { - "sim":119.0, - "partner":"6wk9" - }, - { - "sim":119.0, - "partner":"7svx" - }, - { - "sim":119.0, - "partner":"8tgy" - }, - { - "sim":119.0, - "partner":"7szt" - }, - { - "sim":119.0, - "partner":"6wk5" - }, - { - "sim":119.0, - "partner":"7ssu" - }, - { - "sim":119.0, - "partner":"7sv9" - }, - { - "sim":119.0, - "partner":"6wk8" - }, - { - "sim":119.0, - "partner":"7yld" - }, - { - "sim":118.0, - "partner":"1mfn" - }, - { - "sim":118.0, - "partner":"2mfn" - }, - { - "sim":117.0, - "partner":"3qwq" - }, - { - "sim":115.0, - "partner":"4ov6" - }, - { - "sim":114.0, - "partner":"7ylb" - }, - { - "sim":112.0, - "partner":"3qwr" - }, - { - "sim":109.0, - "partner":"2ck2" - }, - { - "sim":104.0, - "partner":"4s0s" - }, - { - "sim":104.0, - "partner":"4s0t" - }, - { - "sim":103.0, - "partner":"7t0o" - }, - { - "sim":102.0, - "partner":"7t0r" - }, - { - "sim":102.0, - "partner":"5j7c" - }, - { - "sim":100.0, - "partner":"7ypl" - }, - { - "sim":64.0, - "partner":"3teu" - }, - { - "sim":60.0, - "partner":"3tes" - }, - { - "sim":53.0, - "partner":"6hnf" - }, - { - "sim":53.0, - "partner":"1fnh" - }, - { - "sim":53.0, - "partner":"3r8q" - }, { "sim":208.0, "partner":"6amv" @@ -979254,10 +983305,34 @@ "sim":207.0, "partner":"1ab2" }, + { + "sim":207.0, + "partner":"5dc0" + }, + { + "sim":207.0, + "partner":"3t04" + }, + { + "sim":207.0, + "partner":"5dc4" + }, + { + "sim":207.0, + "partner":"3uyo" + }, + { + "sim":207.0, + "partner":"5dc9" + }, { "sim":207.0, "partner":"4xey" }, + { + "sim":206.0, + "partner":"3k2m" + }, { "sim":204.0, "partner":"2abl" @@ -979274,10 +983349,6 @@ "sim":83.0, "partner":"1a81" }, - { - "sim":83.0, - "partner":"7q5u" - }, { "sim":83.0, "partner":"7q5w" @@ -979290,6 +983361,10 @@ "sim":83.0, "partner":"7q63" }, + { + "sim":83.0, + "partner":"7q5u" + }, { "sim":83.0, "partner":"7sa7" @@ -979330,26 +983405,10 @@ "sim":74.0, "partner":"2hck" }, - { - "sim":74.0, - "partner":"2c0o" - }, - { - "sim":74.0, - "partner":"3vs3" - }, - { - "sim":74.0, - "partner":"3vs4" - }, { "sim":74.0, "partner":"3vs5" }, - { - "sim":74.0, - "partner":"9byj" - }, { "sim":74.0, "partner":"3vs6" @@ -979362,6 +983421,10 @@ "sim":74.0, "partner":"2c0t" }, + { + "sim":74.0, + "partner":"9byj" + }, { "sim":74.0, "partner":"2c0i" @@ -979418,6 +983481,18 @@ "sim":74.0, "partner":"1qcf" }, + { + "sim":74.0, + "partner":"3vs3" + }, + { + "sim":74.0, + "partner":"2c0o" + }, + { + "sim":74.0, + "partner":"3vs4" + }, { "sim":73.0, "partner":"2rsy" @@ -979450,6 +983525,14 @@ "sim":72.0, "partner":"8x2p" }, + { + "sim":140.0, + "partner":"5mtm" + }, + { + "sim":136.0, + "partner":"5mtn" + }, { "sim":72.0, "partner":"1k9a" @@ -979490,6 +983573,10 @@ "sim":70.0, "partner":"2mrj" }, + { + "sim":151.0, + "partner":"5mtj" + }, { "sim":70.0, "partner":"4u1p" @@ -979508,11 +983595,11 @@ }, { "sim":70.0, - "partner":"7uy0" + "partner":"7uy3" }, { "sim":70.0, - "partner":"7uy3" + "partner":"7uy0" }, { "sim":69.0, @@ -979568,15 +983655,15 @@ }, { "sim":66.0, - "partner":"1a09" + "partner":"1shd" }, { "sim":66.0, - "partner":"1a1e" + "partner":"1a09" }, { "sim":66.0, - "partner":"1shd" + "partner":"1a1e" }, { "sim":66.0, @@ -979594,18 +983681,6 @@ "sim":66.0, "partner":"1a1b" }, - { - "sim":66.0, - "partner":"1o4k" - }, - { - "sim":66.0, - "partner":"1o4l" - }, - { - "sim":66.0, - "partner":"1o4m" - }, { "sim":66.0, "partner":"1o4n" @@ -979702,6 +983777,18 @@ "sim":66.0, "partner":"1o4j" }, + { + "sim":66.0, + "partner":"1o4k" + }, + { + "sim":66.0, + "partner":"1o4l" + }, + { + "sim":66.0, + "partner":"1o4m" + }, { "sim":66.0, "partner":"4k11" @@ -979712,11 +983799,11 @@ }, { "sim":66.0, - "partner":"1fmk" + "partner":"2src" }, { "sim":66.0, - "partner":"2src" + "partner":"1fmk" }, { "sim":66.0, @@ -979788,11 +983875,11 @@ }, { "sim":63.0, - "partner":"1cj1" + "partner":"6vk2" }, { "sim":63.0, - "partner":"6vk2" + "partner":"1cj1" }, { "sim":63.0, @@ -979836,27 +983923,27 @@ }, { "sim":63.0, - "partner":"1spr" + "partner":"1sps" }, { "sim":63.0, - "partner":"1shb" + "partner":"1x0n" }, { "sim":63.0, - "partner":"1sps" + "partner":"1qg1" }, { "sim":63.0, - "partner":"1x0n" + "partner":"1sha" }, { "sim":63.0, - "partner":"1qg1" + "partner":"1spr" }, { "sim":63.0, - "partner":"1sha" + "partner":"1shb" }, { "sim":63.0, @@ -979898,10 +983985,6 @@ "sim":63.0, "partner":"3c7i" }, - { - "sim":63.0, - "partner":"3s8o" - }, { "sim":63.0, "partner":"3imd" @@ -979940,16 +984023,20 @@ }, { "sim":63.0, - "partner":"1bm2" + "partner":"3s8l" }, { "sim":63.0, - "partner":"3s8l" + "partner":"1bm2" }, { "sim":63.0, "partner":"4p9z" }, + { + "sim":63.0, + "partner":"6wo2" + }, { "sim":63.0, "partner":"3n8m" @@ -979960,12 +984047,20 @@ }, { "sim":63.0, - "partner":"6wo2" + "partner":"3s8o" }, { "sim":63.0, "partner":"1bmb" }, + { + "sim":63.0, + "partner":"8vcg" + }, + { + "sim":63.0, + "partner":"8vcf" + }, { "sim":63.0, "partner":"1gri" @@ -980040,19 +984135,15 @@ }, { "sim":62.0, - "partner":"7jvm" - }, - { - "sim":62.0, - "partner":"7jvn" + "partner":"8gww" }, { "sim":62.0, - "partner":"8gww" + "partner":"7jvm" }, { "sim":62.0, - "partner":"5i6v" + "partner":"7jvn" }, { "sim":62.0, @@ -980060,11 +984151,11 @@ }, { "sim":62.0, - "partner":"7rct" + "partner":"5i6v" }, { "sim":62.0, - "partner":"6md7" + "partner":"7rct" }, { "sim":62.0, @@ -980072,11 +984163,11 @@ }, { "sim":62.0, - "partner":"8t7q" + "partner":"6md9" }, { "sim":62.0, - "partner":"6md9" + "partner":"8t7q" }, { "sim":62.0, @@ -980086,10 +984177,6 @@ "sim":62.0, "partner":"6mdb" }, - { - "sim":62.0, - "partner":"5ibm" - }, { "sim":62.0, "partner":"6mdc" @@ -980100,11 +984187,11 @@ }, { "sim":62.0, - "partner":"8wx7" + "partner":"8b5y" }, { "sim":62.0, - "partner":"5ehp" + "partner":"5ibm" }, { "sim":62.0, @@ -980112,15 +984199,15 @@ }, { "sim":62.0, - "partner":"8b5y" + "partner":"5ehp" }, { "sim":62.0, - "partner":"8t8q" + "partner":"6bmu" }, { "sim":62.0, - "partner":"8t6g" + "partner":"8cbh" }, { "sim":62.0, @@ -980128,11 +984215,7 @@ }, { "sim":62.0, - "partner":"6bmu" - }, - { - "sim":62.0, - "partner":"8cbh" + "partner":"8t8q" }, { "sim":62.0, @@ -980144,7 +984227,7 @@ }, { "sim":62.0, - "partner":"8t6d" + "partner":"8t6g" }, { "sim":62.0, @@ -980160,23 +984243,27 @@ }, { "sim":62.0, - "partner":"6atd" + "partner":"8t6d" }, { "sim":62.0, - "partner":"6cmp" + "partner":"8wx7" }, { "sim":62.0, - "partner":"6cmr" + "partner":"6md7" }, { "sim":62.0, - "partner":"7r75" + "partner":"6atd" }, { "sim":62.0, - "partner":"7r7l" + "partner":"6cmp" + }, + { + "sim":62.0, + "partner":"6cmr" }, { "sim":62.0, @@ -980224,80 +984311,88 @@ }, { "sim":62.0, - "partner":"8rzw" + "partner":"7r75" }, { "sim":62.0, - "partner":"8s0h" + "partner":"7r7l" }, { "sim":62.0, - "partner":"8rzy" + "partner":"8s0o" }, { "sim":62.0, - "partner":"8s0i" + "partner":"8s0p" }, { "sim":62.0, - "partner":"8s0j" + "partner":"8s0q" }, { "sim":62.0, - "partner":"8s01" + "partner":"8s0s" }, { "sim":62.0, - "partner":"8s0k" + "partner":"8rzw" }, { "sim":62.0, - "partner":"8s04" + "partner":"8s0h" }, { "sim":62.0, - "partner":"8s06" + "partner":"8rzy" }, { "sim":62.0, - "partner":"8s07" + "partner":"8s0i" }, { "sim":62.0, - "partner":"8s0o" + "partner":"8s0j" }, { "sim":62.0, - "partner":"8s0p" + "partner":"8s01" }, { "sim":62.0, - "partner":"8s0q" + "partner":"8s0k" }, { "sim":62.0, - "partner":"8s0s" + "partner":"8s04" }, { "sim":62.0, - "partner":"9blg" + "partner":"8s06" }, { "sim":62.0, - "partner":"4nwf" + "partner":"8s07" }, { "sim":62.0, - "partner":"4nwg" + "partner":"8u7w" }, { "sim":62.0, - "partner":"8u7w" + "partner":"4nwf" }, { "sim":62.0, "partner":"8u7x" }, + { + "sim":62.0, + "partner":"4nwg" + }, + { + "sim":62.0, + "partner":"9blg" + }, { "sim":62.0, "partner":"4h1o" @@ -980343,12 +984438,12 @@ "partner":"6roz" }, { - "sim":61.0, - "partner":"4qsy" + "sim":147.0, + "partner":"4je4" }, { "sim":61.0, - "partner":"3tkz" + "partner":"4qsy" }, { "sim":61.0, @@ -980358,6 +984453,10 @@ "sim":61.0, "partner":"2mk2" }, + { + "sim":61.0, + "partner":"3tkz" + }, { "sim":61.0, "partner":"2ekx" @@ -980408,15 +984507,15 @@ }, { "sim":60.0, - "partner":"2rvf" + "partner":"1f1w" }, { "sim":60.0, - "partner":"1f1w" + "partner":"1f2f" }, { "sim":60.0, - "partner":"1f2f" + "partner":"2rvf" }, { "sim":60.0, @@ -980464,11 +984563,15 @@ }, { "sim":59.0, - "partner":"2mc1" + "partner":"2lct" }, { "sim":59.0, - "partner":"2lct" + "partner":"2mc1" + }, + { + "sim":138.0, + "partner":"4jeg" }, { "sim":59.0, @@ -980510,6 +984613,14 @@ "sim":57.0, "partner":"8gmb" }, + { + "sim":121.0, + "partner":"4jmh" + }, + { + "sim":126.0, + "partner":"4jmg" + }, { "sim":56.0, "partner":"4xi2" @@ -980576,11 +984687,11 @@ }, { "sim":53.0, - "partner":"6pbc" + "partner":"7z3j" }, { "sim":53.0, - "partner":"7z3j" + "partner":"6pbc" }, { "sim":53.0, @@ -980705,698 +984816,732 @@ { "sim":50.0, "partner":"1ju5" - } - ], - "struct_thr_sim_designed":[ - - ], - "struct_thr_sim_natural":[ - - ], - "seq_max_sim_designed":{ - "sim":209.0, - "partner":"9f01" - }, - "seq_max_sim_natural":{ - "sim":208.0, - "partner":"6amv" - }, - "struct_max_sim_designed":[ - - ], - 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"sim":130.0, - "partner":"5mtn" + "chain_id":"A,B,C,D", + "chain_source":"unknown", + "chain_type":"U", + "chain_seq_unnat":"(DGL)(DLY)(DHI)(DSN)(DTR)(DTY)(DHI)G(DPR)(DVA)(DSN)(DAR)(DSG)(DAL)(DAL)(DGL)(DTY)(DLE)(DLE)(DSN)(DSN)G(DIL)(DSG)G(DSN)(DPN)(DLE)(DVA)(DAR)(DGL)(DSN)(DGL)(DSN)(DSN)(DPR)G(DGN)(DAR)(DSN)(DIL)(DSN)(DLE)(DAR)(DTY)(DGL)G(DAR)(DVA)(DTY)(DHI)(DTY)(DAR)(DIL)(DSG)(DTH)(DCY)(DSN)(DAS)G(DLY)(DLE)(DTY)(DVA)(DSN)(DSN)(DGL)(DSN)(DAR)(DPN)(DSG)(DTH)(DLE)(DAL)(DGL)(DLE)(DVA)(DHI)(DHI)(DHI)(DSN)(DTH)(DVA)(DAL)(DAS)G(DLE)(DIL)(DTH)(DTH)(DLE)(DHI)(DTY)(DPR)(DAL)(DPR)(DLY)(DAR)(DSG)", + "chain_seq_nat":"EKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTCSDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRN", + "chain_length":100 }, { - "sim":130.0, - "partner":"3qwq" + "chain_id":"E,F,G,H", + "chain_source":"unknown", + "chain_type":"U", + "chain_seq_unnat":"GSMAASSVPTKLEVVAATPTSLLISWDAPAVTVDHYVITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYASDYYDGEISWYSPISINYRT", + "chain_seq_nat":"GSMAASSVPTKLEVVAATPTSLLISWDAPAVTVDHYVITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYASDYYDGEISWYSPISINYRT", + "chain_length":99 + } + ], + "authors":[ + { + "forename":"N.", + "surname":"Schmidt" }, { - "sim":207.0, - "partner":"3t04" + "forename":"A.", + "surname":"Kumar" }, { - "sim":128.0, - "partner":"7yld" + "forename":"L.", + "surname":"Korf" }, { - "sim":128.0, - "partner":"1mfn" + "forename":"A.V.", + "surname":"Dinh-Fricke" }, { - "sim":128.0, - "partner":"2mfn" + "forename":"F.", + "surname":"Abendroth" }, { - "sim":127.0, - "partner":"3qwr" + "forename":"A.", + "surname":"Koide" }, { - "sim":126.0, - "partner":"4ov6" + "forename":"U.", + "surname":"Linne" }, { - "sim":124.0, - "partner":"7ylb" + "forename":"M.", + "surname":"Rakwalska-Bange" }, { - "sim":119.0, - "partner":"2ck2" + "forename":"S.", + "surname":"Koide" }, { - "sim":117.0, - "partner":"4s0s" + "forename":"L.O.", + "surname":"Essen" }, { - "sim":117.0, - "partner":"4s0t" + "forename":"O.", + "surname":"Vazquez" }, { - "sim":114.0, - "partner":"7ypl" + "forename":"O.", + "surname":"Hantschel" + } + ], + "classification":"unknown", + "classification_suggested":[ + + ], + "classification_suggested_reason":[ + + ], + "subtitle":"Complex between d-sh2 domain of abl with monobody 'dam21", + "tags":[ + "complex", + "d-protein", + "nanobody", + "protein binding", + "sh2 domain", + "mirror-image phage display" + ], + "keywords":[ + "development", + "show", + "methods", + "complexes", + "tyrosine", + "delivery", + "make", + "folding", + "readily", + "binding", + "cells", + "demonstrate", + "composed", + "physiological", + "two", + "crystal", + "attractive", + "either", + "prepare", + "represents", + "step", + "accessible", + "particularly", + "residues", + "endogenous", + "library", + "bind", + "stability", + "combined", + "proteins", + "develop", + "achieved", + "cytoplasmic", + "size", + "use", + "small", + "consequently", + "chemical", + "future", + "nanomolar", + "leukemic", + "lysates", + "metabolic", + "lack", + "pocket", + "exhibit", + "bcr", + "selection", + "work", + "functional", + "inhibit", + "hence", + "display", + "proper", + "domain", + "possible", + "targeting", + "synthesis", + "ligation", + "cysteine", + "therapeutic", + "cell", + "chemically", + "shown", + "immunogenicity", + "monobodies", + "mode", + "unconventional", + "permeabilized", + "modality", + "developed", + "reveal", + "ligating", + "kinase", + "structures", + "synthesized", + "plasma", + "without", + "important", + "synthetic", + "determined", + "py", + "enable", + "phage", + "towards", + "high", + "activity", + "heterochiral", + "acids", + "potent", + "affinities", + "emerging" + ], + "release_date":"2024-12-25", + "publication":"\"Development of mirror-image monobodies targeting the oncogenic BCR::ABL1 kinase\", Nat Commun, 15, 10724-10724", + "publication_ref":{ + "DOI":"10.1038\/s41467-024-54901-y", + "PubMed":"39715735", + "CSD":"", + "ISSN":"2041-1723", + "ASTM":"" + }, + "publication_country":"UK", + "abstract":"Mirror-image proteins, composed of D-amino acids, are an attractive therapeutic modality, as they exhibit high metabolic stability and lack immunogenicity. Development of mirror-image binding proteins is achieved through chemical synthesis of D-target proteins, phage display library selection of L-binders and chemical synthesis of (mirror-image) D-binders that consequently bind the physiological L-targets. Monobodies are well-established synthetic (L-)binding proteins and their small size (~90 residues) and lack of endogenous cysteine residues make them particularly accessible to chemical synthesis. Here, we develop monobodies with nanomolar binding affinities against the D-SH2 domain of the leukemic tyrosine kinase BCR::ABL1. Two crystal structures of heterochiral monobody-SH2 complexes reveal targeting of the pY binding pocket by an unconventional binding mode. We then prepare potent D-monobodies by either ligating two chemically synthesized D-peptides or by self-assembly without ligation. Their proper folding and stability are determined and high-affinity binding to the L-target is shown. D-monobodies are protease-resistant, show long-term plasma stability, inhibit BCR::ABL1 kinase activity and bind BCR::ABL1 in cell lysates and permeabilized cells. Hence, we demonstrate that functional D-monobodies can be developed readily. Our work represents an important step towards possible future therapeutic use of D-monobodies when combined with emerging methods to enable cytoplasmic delivery of monobodies.", + "crystal_structure":{ + "length_a":"76.637", + "length_b":"62.290", + "length_c":"116.664", + "angle_a":"90.00", + "angle_b":"98.06", + "angle_g":"90.00" + }, + "symmetry":"P 1 21 1", + "exptl_method":[ + "X-RAY DIFFRACTION" + ], + "formula_weight":11206.376, + "synthesis_comment":"", + "review":true, + "previous_design":"9f00", + "next_design":"9f07", + "seq_thr_sim_designed":[ + { + "sim":209.0, + "partner":"9f00" }, { - "sim":110.0, - "partner":"5j7c" + "sim":133.0, + "partner":"3qht" }, { - "sim":106.0, - "partner":"7t0r" + "sim":63.0, + "partner":"4lpu" }, { - "sim":106.0, - "partner":"7t0o" + "sim":62.0, + "partner":"4lpw" }, { - "sim":64.0, - "partner":"3teu" + "sim":61.0, + "partner":"4lpy" }, { "sim":59.0, - "partner":"3tes" + "partner":"4m6a" }, { - "sim":57.0, - "partner":"6hnf" + "sim":59.0, + "partner":"4lpv" }, { - "sim":57.0, - "partner":"1fnh" + "sim":59.0, + "partner":"4lpx" }, { - "sim":57.0, - "partner":"3r8q" + "sim":59.0, + "partner":"4lpt" }, { - "sim":51.0, - "partner":"7t87" + "sim":57.0, + "partner":"4u3h" }, { - "sim":50.0, - "partner":"2ekj" - }, + "sim":56.0, + "partner":"5l2h" + } + ], + "seq_thr_sim_natural":[ { "sim":208.0, "partner":"6amv" @@ -981429,6 +985574,30 @@ "sim":208.0, "partner":"1opl" }, + { + "sim":207.0, + "partner":"3k2m" + }, + { + "sim":207.0, + "partner":"5dc0" + }, + { + "sim":207.0, + "partner":"3t04" + }, + { + "sim":207.0, + "partner":"5dc4" + }, + { + "sim":207.0, + "partner":"3uyo" + }, + { + "sim":207.0, + "partner":"5dc9" + }, { "sim":205.0, "partner":"1ab2" @@ -981449,10 +985618,6 @@ "sim":83.0, "partner":"1a81" }, - { - "sim":83.0, - "partner":"7q5u" - }, { "sim":83.0, "partner":"7q5w" @@ -981465,6 +985630,10 @@ "sim":83.0, "partner":"7q63" }, + { + "sim":83.0, + "partner":"7q5u" + }, { "sim":83.0, "partner":"7sa7" @@ -981505,26 +985674,10 @@ "sim":73.0, "partner":"2hck" }, - { - "sim":73.0, - "partner":"2c0o" - }, - { - "sim":73.0, - "partner":"3vs3" - }, - { - "sim":73.0, - "partner":"3vs4" - }, { "sim":73.0, "partner":"3vs5" }, - { - "sim":73.0, - "partner":"9byj" - }, { "sim":73.0, "partner":"3vs6" @@ -981537,6 +985690,10 @@ "sim":73.0, "partner":"2c0t" }, + { + "sim":73.0, + "partner":"9byj" + }, { "sim":73.0, "partner":"2c0i" @@ -981593,6 +985750,18 @@ "sim":73.0, "partner":"1qcf" }, + { + "sim":73.0, + "partner":"3vs3" + }, + { + "sim":73.0, + "partner":"2c0o" + }, + { + "sim":73.0, + "partner":"3vs4" + }, { "sim":72.0, "partner":"2dly" @@ -981653,6 +985822,14 @@ "sim":70.0, "partner":"2mrj" }, + { + "sim":136.0, + "partner":"5mtm" + }, + { + "sim":130.0, + "partner":"5mtn" + }, { "sim":70.0, "partner":"4u1p" @@ -981673,6 +985850,10 @@ "sim":69.0, "partner":"1lcj" }, + { + "sim":162.0, + "partner":"5mtj" + }, { "sim":69.0, "partner":"1x27" @@ -981687,11 +985868,11 @@ }, { "sim":69.0, - "partner":"7uy0" + "partner":"7uy3" }, { "sim":69.0, - "partner":"7uy3" + "partner":"7uy0" }, { "sim":68.0, @@ -981735,11 +985916,11 @@ }, { "sim":66.0, - "partner":"1fmk" + "partner":"2src" }, { "sim":66.0, - "partner":"2src" + "partner":"1fmk" }, { "sim":66.0, @@ -981787,15 +985968,15 @@ }, { "sim":64.0, - "partner":"1a09" + "partner":"1shd" }, { "sim":64.0, - "partner":"1a1e" + "partner":"1a09" }, { "sim":64.0, - "partner":"1shd" + "partner":"1a1e" }, { "sim":64.0, @@ -981813,18 +985994,6 @@ "sim":64.0, "partner":"1a1b" }, - { - "sim":64.0, - "partner":"1o4k" - }, - { - "sim":64.0, - "partner":"1o4l" - }, - { - "sim":64.0, - "partner":"1o4m" - }, { "sim":64.0, "partner":"1o4n" @@ -981921,6 +986090,18 @@ "sim":64.0, "partner":"1o4j" }, + { + "sim":64.0, + "partner":"1o4k" + }, + { + "sim":64.0, + "partner":"1o4l" + }, + { + "sim":64.0, + "partner":"1o4m" + }, { "sim":64.0, "partner":"1bkl" @@ -981939,11 +986120,11 @@ }, { "sim":63.0, - "partner":"1cj1" + "partner":"6vk2" }, { "sim":63.0, - "partner":"6vk2" + "partner":"1cj1" }, { "sim":63.0, @@ -981995,27 +986176,27 @@ }, { "sim":63.0, - "partner":"1spr" + "partner":"1sps" }, { "sim":63.0, - "partner":"1shb" + "partner":"1x0n" }, { "sim":63.0, - "partner":"1sps" + "partner":"1qg1" }, { "sim":63.0, - "partner":"1x0n" + "partner":"1sha" }, { "sim":63.0, - "partner":"1qg1" + "partner":"1spr" }, { "sim":63.0, - "partner":"1sha" + "partner":"1shb" }, { "sim":63.0, @@ -982053,10 +986234,6 @@ "sim":63.0, "partner":"3c7i" }, - { - "sim":63.0, - "partner":"3s8o" - }, { "sim":63.0, "partner":"3imd" @@ -982101,6 +986278,10 @@ "sim":63.0, "partner":"4p9z" }, + { + "sim":63.0, + "partner":"6wo2" + }, { "sim":63.0, "partner":"3n8m" @@ -982111,7 +986292,7 @@ }, { "sim":63.0, - "partner":"6wo2" + "partner":"3s8o" }, { "sim":63.0, @@ -982179,19 +986360,19 @@ }, { "sim":62.0, - "partner":"5x94" + "partner":"8vcg" }, { "sim":62.0, - "partner":"5x7b" + "partner":"8vcf" }, { "sim":62.0, - "partner":"7jvm" + "partner":"5x94" }, { "sim":62.0, - "partner":"7jvn" + "partner":"5x7b" }, { "sim":62.0, @@ -982199,11 +986380,11 @@ }, { "sim":62.0, - "partner":"8wfy" + "partner":"7jvm" }, { "sim":62.0, - "partner":"5i6v" + "partner":"7jvn" }, { "sim":62.0, @@ -982211,23 +986392,23 @@ }, { "sim":62.0, - "partner":"7rct" + "partner":"5i6v" }, { "sim":62.0, - "partner":"2shp" + "partner":"8wfy" }, { "sim":62.0, - "partner":"6md7" + "partner":"7rct" }, { "sim":62.0, - "partner":"7vxg" + "partner":"2shp" }, { "sim":62.0, - "partner":"8t7q" + "partner":"7vxg" }, { "sim":62.0, @@ -982235,15 +986416,15 @@ }, { "sim":62.0, - "partner":"6mda" + "partner":"8t7q" }, { "sim":62.0, - "partner":"6mdb" + "partner":"6mda" }, { "sim":62.0, - "partner":"5ibm" + "partner":"6mdb" }, { "sim":62.0, @@ -982255,11 +986436,11 @@ }, { "sim":62.0, - "partner":"8wx7" + "partner":"8b5y" }, { "sim":62.0, - "partner":"5ehp" + "partner":"5ibm" }, { "sim":62.0, @@ -982267,15 +986448,15 @@ }, { "sim":62.0, - "partner":"8b5y" + "partner":"5ehp" }, { "sim":62.0, - "partner":"8t8q" + "partner":"6bmu" }, { "sim":62.0, - "partner":"8t6g" + "partner":"8cbh" }, { "sim":62.0, @@ -982283,11 +986464,7 @@ }, { "sim":62.0, - "partner":"6bmu" - }, - { - "sim":62.0, - "partner":"8cbh" + "partner":"8t8q" }, { "sim":62.0, @@ -982299,7 +986476,7 @@ }, { "sim":62.0, - "partner":"8t6d" + "partner":"8t6g" }, { "sim":62.0, @@ -982315,23 +986492,27 @@ }, { "sim":62.0, - "partner":"6atd" + "partner":"8t6d" }, { "sim":62.0, - "partner":"6cmp" + "partner":"8wx7" }, { "sim":62.0, - "partner":"6cmr" + "partner":"6md7" }, { "sim":62.0, - "partner":"7r75" + "partner":"6atd" }, { "sim":62.0, - "partner":"7r7l" + "partner":"6cmp" + }, + { + "sim":62.0, + "partner":"6cmr" }, { "sim":62.0, @@ -982379,80 +986560,88 @@ }, { "sim":62.0, - "partner":"8rzw" + "partner":"7r75" }, { "sim":62.0, - "partner":"8s0h" + "partner":"7r7l" }, { "sim":62.0, - "partner":"8rzy" + "partner":"8s0o" }, { "sim":62.0, - "partner":"8s0i" + "partner":"8s0p" }, { "sim":62.0, - "partner":"8s0j" + "partner":"8s0q" }, { "sim":62.0, - "partner":"8s01" + "partner":"8s0s" }, { "sim":62.0, - "partner":"8s0k" + "partner":"8rzw" }, { "sim":62.0, - "partner":"8s04" + "partner":"8s0h" }, { "sim":62.0, - "partner":"8s06" + "partner":"8rzy" }, { "sim":62.0, - "partner":"8s07" + "partner":"8s0i" }, { "sim":62.0, - "partner":"8s0o" + "partner":"8s0j" }, { "sim":62.0, - "partner":"8s0p" + "partner":"8s01" }, { "sim":62.0, - "partner":"8s0q" + "partner":"8s0k" }, { "sim":62.0, - "partner":"8s0s" + "partner":"8s04" }, { "sim":62.0, - "partner":"9blg" + "partner":"8s06" }, { "sim":62.0, - "partner":"4nwf" + "partner":"8s07" }, { "sim":62.0, - "partner":"4nwg" + "partner":"8u7w" }, { "sim":62.0, - "partner":"8u7w" + "partner":"4nwf" }, { "sim":62.0, "partner":"8u7x" }, + { + "sim":62.0, + "partner":"4nwg" + }, + { + "sim":62.0, + "partner":"9blg" + }, { "sim":62.0, "partner":"4gwf" @@ -982518,12 +986707,12 @@ "partner":"6roz" }, { - "sim":61.0, - "partner":"4qsy" + "sim":141.0, + "partner":"4je4" }, { "sim":61.0, - "partner":"3tkz" + "partner":"4qsy" }, { "sim":61.0, @@ -982533,6 +986722,10 @@ "sim":61.0, "partner":"2mk2" }, + { + "sim":61.0, + "partner":"3tkz" + }, { "sim":61.0, "partner":"2ysx" @@ -982579,15 +986772,15 @@ }, { "sim":60.0, - "partner":"2rvf" + "partner":"1f1w" }, { "sim":60.0, - "partner":"1f1w" + "partner":"1f2f" }, { "sim":60.0, - "partner":"1f2f" + "partner":"2rvf" }, { "sim":60.0, @@ -982629,6 +986822,10 @@ "sim":59.0, "partner":"1d1z" }, + { + "sim":137.0, + "partner":"4jeg" + }, { "sim":59.0, "partner":"6cmq" @@ -982673,6 +986870,14 @@ "sim":56.0, "partner":"4tzi" }, + { + "sim":131.0, + "partner":"4jmh" + }, + { + "sim":139.0, + "partner":"4jmg" + }, { "sim":56.0, "partner":"3cxl" @@ -982735,11 +986940,11 @@ }, { "sim":53.0, - "partner":"6pbc" + "partner":"7z3j" }, { "sim":53.0, - "partner":"7z3j" + "partner":"6pbc" }, { "sim":53.0, @@ -982856,6 +987061,458 @@ { "sim":50.0, "partner":"2kk6" + }, + { + "sim":165.0, + "partner":"8pr7" + }, + { + "sim":164.0, + "partner":"6c83" + }, + { + "sim":164.0, + "partner":"6cpg" + }, + { + "sim":164.0, + "partner":"8sso" + }, + { + "sim":159.0, + "partner":"6zzd" + }, + { + "sim":158.0, + "partner":"5ecj" + }, + { + "sim":157.0, + "partner":"6bx5" + }, + { + "sim":157.0, + "partner":"5e95" + }, + { + "sim":156.0, + "partner":"6o03" + }, + { + "sim":156.0, + "partner":"6bqo" + }, + { + "sim":156.0, + "partner":"6byn" + }, + { + "sim":154.0, + "partner":"5n7e" + }, + { + "sim":154.0, + "partner":"6bx4" + }, + { + "sim":154.0, + "partner":"5a43" + }, + { + "sim":154.0, + "partner":"6b2a" + }, + { + "sim":154.0, + "partner":"6b2b" + }, + { + "sim":154.0, + "partner":"6b24" + }, + { + "sim":154.0, + "partner":"6b2d" + }, + { + "sim":154.0, + "partner":"7kk9" + }, + { + "sim":154.0, + "partner":"7kka" + }, + { + "sim":154.0, + "partner":"7kkb" + }, + { + "sim":154.0, + "partner":"5kbn" + }, + { + "sim":154.0, + "partner":"5kom" + }, + { + "sim":154.0, + "partner":"7kk8" + }, + { + "sim":154.0, + "partner":"7kkr" + }, + { + "sim":153.0, + "partner":"5v7p" + }, + { + "sim":153.0, + "partner":"6tlc" + }, + { + "sim":151.0, + "partner":"5oc7" + }, + { + "sim":151.0, + "partner":"6zz8" + }, + { + "sim":151.0, + "partner":"6zzg" + }, + { + "sim":150.0, + "partner":"5c6p" + }, + { + "sim":150.0, + "partner":"4huk" + }, + { + "sim":150.0, + "partner":"4hul" + }, + { + "sim":150.0, + "partner":"4hum" + }, + { + "sim":150.0, + "partner":"4hun" + }, + { + "sim":149.0, + "partner":"8gzv" + }, + { + "sim":149.0, + "partner":"8gzw" + }, + { + "sim":149.0, + "partner":"8h1o" + }, + { + "sim":149.0, + "partner":"8gzx" + }, + { + "sim":149.0, + "partner":"8gzy" + }, + { + "sim":149.0, + "partner":"2ocf" + }, + { + "sim":147.0, + "partner":"8ezg" + }, + { + "sim":147.0, + "partner":"4mmy" + }, + { + "sim":147.0, + "partner":"4mmz" + }, + { + "sim":147.0, + "partner":"7jxu" + }, + { + "sim":147.0, + "partner":"6xay" + }, + { + "sim":146.0, + "partner":"6zzc" + }, + { + "sim":146.0, + "partner":"9cqi" + }, + { + "sim":146.0, + "partner":"4lxo" + }, + { + "sim":145.0, + "partner":"5nkq" + }, + { + "sim":145.0, + "partner":"5kvm" + }, + { + "sim":145.0, + "partner":"8f0m" + }, + { + "sim":145.0, + "partner":"4mmx" + }, + { + "sim":144.0, + "partner":"1ttf" + }, + { + "sim":144.0, + "partner":"1ttg" + }, + { + "sim":144.0, + "partner":"7nwl" + }, + { + "sim":144.0, + "partner":"1fnf" + }, + { + "sim":143.0, + "partner":"6apx" + }, + { + "sim":143.0, + "partner":"6o02" + }, + { + "sim":143.0, + "partner":"2qbw" + }, + { + "sim":142.0, + "partner":"5a40" + }, + { + "sim":142.0, + "partner":"6naj" + }, + { + "sim":141.0, + "partner":"3rzw" + }, + { + "sim":141.0, + "partner":"5g15" + }, + { + "sim":141.0, + "partner":"8ssp" + }, + { + "sim":140.0, + "partner":"6sm5" + }, + { + "sim":140.0, + "partner":"6ux8" + }, + { + "sim":140.0, + "partner":"7jw7" + }, + { + "sim":140.0, + "partner":"3csb" + }, + { + "sim":139.0, + "partner":"6d0n" + }, + { + "sim":138.0, + "partner":"1fna" + }, + { + "sim":138.0, + "partner":"3ch8" + }, + { + "sim":137.0, + "partner":"6d0j" + }, + { + "sim":137.0, + "partner":"6d0k" + }, + { + "sim":135.0, + "partner":"7l0g" + }, + { + "sim":134.0, + "partner":"8vxu" + }, + { + "sim":134.0, + "partner":"7mh6" + }, + { + "sim":133.0, + "partner":"6wk9" + }, + { + "sim":133.0, + "partner":"7mgx" + }, + { + "sim":133.0, + "partner":"7svx" + }, + { + "sim":133.0, + "partner":"8tgy" + }, + { + "sim":133.0, + "partner":"7szt" + }, + { + "sim":133.0, + "partner":"6wk5" + }, + { + "sim":133.0, + "partner":"7ssu" + }, + { + "sim":133.0, + "partner":"6wk8" + }, + { + "sim":133.0, + "partner":"7sv9" + }, + { + "sim":133.0, + "partner":"7t00" + }, + { + "sim":133.0, + "partner":"7l0f" + }, + { + "sim":133.0, + "partner":"9cqj" + }, + { + "sim":133.0, + "partner":"2obg" + }, + { + "sim":132.0, + "partner":"7tvj" + }, + { + "sim":131.0, + "partner":"3csg" + }, + { + "sim":130.0, + "partner":"3qwq" + }, + { + "sim":128.0, + "partner":"7yld" + }, + { + "sim":128.0, + "partner":"1mfn" + }, + { + "sim":128.0, + "partner":"2mfn" + }, + { + "sim":127.0, + "partner":"3qwr" + }, + { + "sim":126.0, + "partner":"4ov6" + }, + { + "sim":124.0, + "partner":"7ylb" + }, + { + "sim":119.0, + "partner":"2ck2" + }, + { + "sim":117.0, + "partner":"4s0s" + }, + { + "sim":117.0, + "partner":"4s0t" + }, + { + "sim":114.0, + "partner":"7ypl" + }, + { + "sim":110.0, + "partner":"5j7c" + }, + { + "sim":106.0, + "partner":"7t0r" + }, + { + "sim":106.0, + "partner":"7t0o" + }, + { + "sim":64.0, + "partner":"3teu" + }, + { + "sim":59.0, + "partner":"3tes" + }, + { + "sim":57.0, + "partner":"6hnf" + }, + { + "sim":57.0, + "partner":"1fnh" + }, + { + "sim":57.0, + "partner":"3r8q" + }, + { + "sim":51.0, + "partner":"7t87" + }, + { + "sim":50.0, + "partner":"2ekj" } ], "struct_thr_sim_designed":[ @@ -982946,59 +987603,59 @@ ], "subtitle":"Tubulin:stathmin:darpin:tau mtbr3 complex", "tags":[ - "cell cycle", - "microtubule tau fusion protein" + "microtubule tau fusion protein", + "cell cycle" ], "keywords":[ - "reported", + "complex", "molecular", - "aggregation", - "results", + "phf6", + "structures", + "transposed", "regulation", - "conditions", - "tau", - "oligomerization", - "involved", + "dimer", "axonal", - "protofilaments", - "filamentous", - "fibrils", + "tau", + "pathological", "pore", + "assembly", + "aggregation", + "structure", "microtubule", - "would", - "dimer", - "fragment", - "binds", - "tauopathies", - "motif", - "markers", - "transposed", + "results", "new", - "phf6", - "microtubules", - "structures", + "markers", + "fragment", "protein", + "oligomerization", + "known", "bound", - "present", - "complex", - "construct", - "structure", - "assembly", - "hypotheses", - "tubulin", + "microtubules", "diseases", + "oligopeptide", + "fibrils", "comprising", - "neurons", - "known", + "would", + "motif", + "stabilization", + "tubulin", + "conditions", + "correspond", + "site", "raise", + "reported", + "forms", + "tauopathies", + "filamentous", + "present", "neurodegenerative", - "pathological", - "site", + "hypotheses", "aggregates", - "forms", - "correspond", - "oligopeptide", - "stabilization" + "construct", + "involved", + "binds", + "neurons", + "protofilaments" ], "release_date":"2024-11-13", "publication":"\"The structure of a Tau fragment bound to tubulin prompts new hypotheses on Tau mechanism and oligomerization\", Pnas Nexus, 3, pgae487-pgae487", @@ -983035,19 +987692,19 @@ }, { "sim":280.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":280.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":280.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":280.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":280.0, @@ -983055,35 +987712,35 @@ }, { "sim":280.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":280.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":280.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":280.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":280.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":280.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":280.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":280.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":277.0, @@ -983115,7 +987772,7 @@ }, { "sim":265.0, - "partner":"4j8y" + "partner":"5knh" }, { "sim":265.0, @@ -983123,7 +987780,7 @@ }, { "sim":265.0, - "partner":"5knh" + "partner":"4j8y" }, { "sim":262.0, @@ -983179,7 +987836,7 @@ }, { "sim":248.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":248.0, @@ -983187,7 +987844,7 @@ }, { "sim":248.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":247.0, @@ -983295,11 +987952,11 @@ }, { "sim":208.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":208.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":208.0, @@ -983321,6 +987978,10 @@ "sim":196.0, "partner":"8ak1" }, + { + "sim":190.0, + "partner":"9glq" + }, { "sim":190.0, "partner":"4qfv" @@ -983347,11 +988008,11 @@ }, { "sim":182.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":182.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":172.0, @@ -983359,11 +988020,11 @@ }, { "sim":171.0, - "partner":"5kba" + "partner":"4hqd" }, { "sim":171.0, - "partner":"4hqd" + "partner":"5kba" }, { "sim":169.0, @@ -983407,30 +988068,18 @@ "sim":320.0, "partner":"4hna" }, - { - "sim":280.0, - "partner":"7yz0" - }, { "sim":280.0, "partner":"6mzf" }, { "sim":280.0, - "partner":"7yz1" - }, - { - "sim":280.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":280.0, "partner":"5nqt" }, - { - "sim":280.0, - "partner":"6mze" - }, { "sim":280.0, "partner":"7yz2" @@ -983441,11 +988090,11 @@ }, { "sim":280.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":280.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":280.0, @@ -983457,23 +988106,23 @@ }, { "sim":280.0, - "partner":"4lnu" + "partner":"7yz6" }, { "sim":280.0, - "partner":"7yz6" + "partner":"4lnu" }, { "sim":280.0, - "partner":"4drx" + "partner":"6zwb" }, { "sim":280.0, - "partner":"5nm5" + "partner":"4drx" }, { "sim":280.0, - "partner":"6zwb" + "partner":"5nm5" }, { "sim":280.0, @@ -983487,6 +988136,18 @@ "sim":280.0, "partner":"7yyz" }, + { + "sim":280.0, + "partner":"7yz0" + }, + { + "sim":280.0, + "partner":"7yz1" + }, + { + "sim":280.0, + "partner":"7z01" + }, { "sim":279.0, "partner":"5op1" @@ -983539,45 +988200,25 @@ "sim":273.0, "partner":"2y1l" }, - { - "sim":272.0, - "partner":"5eno" - }, - { - "sim":272.0, - "partner":"6zob" - }, - { - "sim":272.0, - "partner":"6zo5" - }, { "sim":272.0, "partner":"4dx6" }, { "sim":272.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":272.0, "partner":"6zoc" }, - { - "sim":272.0, - "partner":"5enp" - }, - { - "sim":272.0, - "partner":"6sgs" - }, { "sim":272.0, "partner":"6zo6" }, { "sim":272.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":272.0, @@ -983585,7 +988226,7 @@ }, { "sim":272.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":272.0, @@ -983593,11 +988234,11 @@ }, { "sim":272.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":272.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":272.0, @@ -983607,6 +988248,10 @@ "sim":272.0, "partner":"6zoe" }, + { + "sim":272.0, + "partner":"5enq" + }, { "sim":272.0, "partner":"6q4p" @@ -983617,19 +988262,19 @@ }, { "sim":272.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":272.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":272.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":272.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":272.0, @@ -983641,23 +988286,23 @@ }, { "sim":272.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":272.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":272.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":272.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":272.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":272.0, @@ -983669,15 +988314,15 @@ }, { "sim":272.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":272.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":272.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":272.0, @@ -983685,20 +988330,24 @@ }, { "sim":272.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":272.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":272.0, - "partner":"6zoh" + "partner":"4u8y" }, { "sim":272.0, "partner":"3nog" }, + { + "sim":272.0, + "partner":"6sgr" + }, { "sim":272.0, "partner":"4c48" @@ -983713,12 +988362,24 @@ }, { "sim":272.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":272.0, "partner":"4dx5" }, + { + "sim":272.0, + "partner":"5eno" + }, + { + "sim":272.0, + "partner":"6zo5" + }, + { + "sim":272.0, + "partner":"6q4n" + }, { "sim":271.0, "partner":"1svx" @@ -983729,15 +988390,15 @@ }, { "sim":269.0, - "partner":"5oyj" + "partner":"2p2c" }, { "sim":269.0, - "partner":"2p2c" + "partner":"5eyp" }, { "sim":269.0, - "partner":"5eyp" + "partner":"5oyj" }, { "sim":269.0, @@ -983809,11 +988470,11 @@ }, { "sim":259.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":259.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":258.0, @@ -983861,11 +988522,11 @@ }, { "sim":253.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":253.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":253.0, @@ -983883,10 +988544,6 @@ "sim":251.0, "partner":"6s9s" }, - { - "sim":250.0, - "partner":"8tzb" - }, { "sim":250.0, "partner":"8tzc" @@ -983903,6 +988560,10 @@ "sim":250.0, "partner":"8tzh" }, + { + "sim":250.0, + "partner":"8tzb" + }, { "sim":250.0, "partner":"5lw1" @@ -983937,11 +988598,11 @@ }, { "sim":243.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":243.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":243.0, @@ -984061,11 +988722,11 @@ }, { "sim":226.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":226.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":226.0, @@ -984083,10 +988744,6 @@ "sim":222.0, "partner":"4zfh" }, - { - "sim":222.0, - "partner":"8g4f" - }, { "sim":222.0, "partner":"8g42" @@ -984103,6 +988760,10 @@ "sim":222.0, "partner":"8g3k" }, + { + "sim":222.0, + "partner":"8g4f" + }, { "sim":222.0, "partner":"7b6w" @@ -984151,17 +988812,13 @@ "sim":218.0, "partner":"5itz" }, - { - "sim":218.0, - "partner":"6mog" - }, { "sim":218.0, "partner":"6moh" }, { - "sim":216.0, - "partner":"7pd8" + "sim":218.0, + "partner":"6mog" }, { "sim":216.0, @@ -984175,6 +988832,10 @@ "sim":216.0, "partner":"7pdh" }, + { + "sim":216.0, + "partner":"7pd8" + }, { "sim":214.0, "partner":"6mol" @@ -984369,23 +989030,23 @@ }, { "sim":120.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":120.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":120.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":120.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":120.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":120.0, @@ -984393,11 +989054,11 @@ }, { "sim":120.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":120.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":120.0, @@ -984439,10 +989100,6 @@ "sim":109.0, "partner":"2l6b" }, - { - "sim":109.0, - "partner":"5vhj" - }, { "sim":109.0, "partner":"5vhh" @@ -984473,15 +989130,15 @@ }, { "sim":109.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":109.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":109.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":109.0, @@ -984491,6 +989148,10 @@ "sim":109.0, "partner":"7vxw" }, + { + "sim":109.0, + "partner":"1uoh" + }, { "sim":109.0, "partner":"7vy4" @@ -984501,11 +989162,11 @@ }, { "sim":109.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":109.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":109.0, @@ -984517,15 +989178,15 @@ }, { "sim":109.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":109.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":109.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":106.0, @@ -984609,11 +989270,11 @@ }, { "sim":96.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":96.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":95.0, @@ -984653,11 +989314,11 @@ }, { "sim":95.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":95.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":94.0, @@ -984665,16 +989326,24 @@ }, { "sim":94.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":94.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":94.0, "partner":"7roy" }, + { + "sim":94.0, + "partner":"8wqg" + }, + { + "sim":94.0, + "partner":"8wqe" + }, { "sim":94.0, "partner":"8wqh" @@ -984703,14 +989372,6 @@ "sim":94.0, "partner":"8wqd" }, - { - "sim":94.0, - "partner":"8wqg" - }, - { - "sim":94.0, - "partner":"8wqe" - }, { "sim":94.0, "partner":"8je1" @@ -984873,19 +989534,19 @@ }, { "sim":84.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":84.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":84.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":84.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":84.0, @@ -984931,10 +989592,6 @@ "sim":83.0, "partner":"8wui" }, - { - "sim":83.0, - "partner":"6v9x" - }, { "sim":83.0, "partner":"6v9y" @@ -984947,6 +989604,10 @@ "sim":83.0, "partner":"6v9w" }, + { + "sim":83.0, + "partner":"6v9x" + }, { "sim":83.0, "partner":"7or0" @@ -985007,14 +989668,6 @@ "sim":82.0, "partner":"5et0" }, - { - "sim":82.0, - "partner":"6m11" - }, - { - "sim":82.0, - "partner":"6m12" - }, { "sim":82.0, "partner":"6m13" @@ -985039,6 +989692,14 @@ "sim":82.0, "partner":"4o1p" }, + { + "sim":82.0, + "partner":"6m11" + }, + { + "sim":82.0, + "partner":"6m12" + }, { "sim":81.0, "partner":"3zkj" @@ -985157,11 +989818,11 @@ }, { "sim":74.0, - "partner":"5z2n" + "partner":"1d9s" }, { "sim":74.0, - "partner":"1d9s" + "partner":"5z2n" }, { "sim":74.0, @@ -985199,10 +989860,6 @@ "sim":74.0, "partner":"5wo6" }, - { - "sim":74.0, - "partner":"5iwr" - }, { "sim":74.0, "partner":"5iwt" @@ -985257,11 +989914,11 @@ }, { "sim":74.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":74.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":74.0, @@ -985301,11 +989958,7 @@ }, { "sim":74.0, - "partner":"7t6m" - }, - { - "sim":74.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":74.0, @@ -985341,15 +989994,19 @@ }, { "sim":74.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":74.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":74.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":74.0, + "partner":"7t6k" }, { "sim":74.0, @@ -985357,7 +990014,7 @@ }, { "sim":74.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":74.0, @@ -985365,7 +990022,11 @@ }, { "sim":74.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":74.0, + "partner":"8ffn" }, { "sim":73.0, @@ -985397,15 +990058,15 @@ }, { "sim":70.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":70.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":70.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":70.0, @@ -985449,11 +990110,11 @@ }, { "sim":68.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":68.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":68.0, @@ -985527,10 +990188,6 @@ "sim":64.0, "partner":"8sp8" }, - { - "sim":64.0, - "partner":"7k4a" - }, { "sim":64.0, "partner":"7k4b" @@ -985553,7 +990210,7 @@ }, { "sim":64.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":64.0, @@ -985569,7 +990226,7 @@ }, { "sim":64.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":64.0, @@ -985581,7 +990238,7 @@ }, { "sim":64.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":64.0, @@ -985601,7 +990258,7 @@ }, { "sim":64.0, - "partner":"9cuh" + "partner":"6bo9" }, { "sim":64.0, @@ -985615,6 +990272,10 @@ "sim":64.0, "partner":"9cuk" }, + { + "sim":64.0, + "partner":"9cuh" + }, { "sim":64.0, "partner":"6sku" @@ -985733,19 +990394,19 @@ }, { "sim":56.0, - "partner":"8u43" + "partner":"8u2z" }, { "sim":56.0, - "partner":"8u4d" + "partner":"8u43" }, { "sim":56.0, - "partner":"8u3a" + "partner":"8u4d" }, { "sim":56.0, - "partner":"8u2z" + "partner":"8u3a" }, { "sim":56.0, @@ -985759,18 +990420,10 @@ "sim":56.0, "partner":"5is0" }, - { - "sim":56.0, - "partner":"7mzc" - }, { "sim":56.0, "partner":"7l2v" }, - { - "sim":56.0, - "partner":"8t3l" - }, { "sim":56.0, "partner":"7mzd" @@ -985781,7 +990434,7 @@ }, { "sim":56.0, - "partner":"8t3m" + "partner":"8t3l" }, { "sim":56.0, @@ -985799,6 +990452,10 @@ "sim":56.0, "partner":"7l2x" }, + { + "sim":56.0, + "partner":"8t3m" + }, { "sim":56.0, "partner":"7l2r" @@ -985833,35 +990490,35 @@ }, { "sim":56.0, - "partner":"8t0y" + "partner":"7mzc" }, { "sim":56.0, - "partner":"8u3l" + "partner":"8t0y" }, { "sim":56.0, - "partner":"8t0c" + "partner":"8u30" }, { "sim":56.0, - "partner":"8u30" + "partner":"8u3c" }, { "sim":56.0, - "partner":"8t0e" + "partner":"8t0c" }, { "sim":56.0, - "partner":"8t10" + "partner":"8t0e" }, { "sim":56.0, - "partner":"8u3c" + "partner":"8t10" }, { "sim":56.0, - "partner":"7l2n" + "partner":"8u3l" }, { "sim":56.0, @@ -985897,32 +990554,28 @@ }, { "sim":56.0, - "partner":"7lqy" + "partner":"7l2n" }, { "sim":56.0, - "partner":"7lqz" + "partner":"7lqy" }, { "sim":56.0, - "partner":"7lr0" + "partner":"7lqz" }, { "sim":56.0, - "partner":"7lpd" + "partner":"7lr0" }, { "sim":56.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":56.0, "partner":"7rqv" }, - { - "sim":56.0, - "partner":"7lpe" - }, { "sim":56.0, "partner":"7rqw" @@ -985955,10 +990608,22 @@ "sim":56.0, "partner":"7lpc" }, + { + "sim":56.0, + "partner":"7rqu" + }, + { + "sim":56.0, + "partner":"7lpd" + }, { "sim":55.0, "partner":"6l93" }, + { + "sim":55.0, + "partner":"8ycp" + }, { "sim":55.0, "partner":"8gf8" @@ -985989,11 +990654,11 @@ }, { "sim":53.0, - "partner":"7ttr" + "partner":"7tts" }, { "sim":53.0, - "partner":"7tts" + "partner":"7ttr" }, { "sim":52.0, @@ -986011,10 +990676,6 @@ "sim":51.0, "partner":"6lgp" }, - { - "sim":51.0, - "partner":"6dvz" - }, { "sim":51.0, "partner":"6dvw" @@ -986025,19 +990686,11 @@ }, { "sim":51.0, - "partner":"6pvo" - }, - { - "sim":51.0, - "partner":"7mij" - }, - { - "sim":51.0, - "partner":"6pvp" + "partner":"6dvz" }, { "sim":51.0, - "partner":"7ras" + "partner":"6pvq" }, { "sim":51.0, @@ -986045,7 +990698,7 @@ }, { "sim":51.0, - "partner":"6pvq" + "partner":"7ras" }, { "sim":51.0, @@ -986059,13 +990712,17 @@ "sim":51.0, "partner":"7mim" }, + { + "sim":51.0, + "partner":"6pvl" + }, { "sim":51.0, "partner":"7min" }, { "sim":51.0, - "partner":"6pvl" + "partner":"6pvm" }, { "sim":51.0, @@ -986077,11 +990734,19 @@ }, { "sim":51.0, - "partner":"6pvm" + "partner":"6pvn" }, { "sim":51.0, - "partner":"6pvn" + "partner":"6pvo" + }, + { + "sim":51.0, + "partner":"6pvp" + }, + { + "sim":51.0, + "partner":"7mij" }, { "sim":50.0, @@ -986584,80 +991249,80 @@ "de novo designed protein k12" ], "keywords":[ - "enabling", - "accuracy", - "performance", - "scope", - "without", - "100", - "density", - "amino", - "proteins", - "multiple", - "approach", - "hallucination", - "report", - "de", - "novo", - "1000", - "also", - "designability", + "designed", + "form", + "heterodimers", + "need", + "offers", + "scalability", + "design", "characterized", - "attractive", "problems", - "sizes", "efficient", - "optimization", - "acids", - "designed", - "method", - "advanced", - "different", + "space", + "learning", + "backbones", + "methods", + "structures", + "de", + "hallucination", "used", + "multiple", "approaches", - "functions", - "pipelines", - "scales", - "broad", - "relaxed", - "two", - "methods", + "enabling", + "field", "experimentally", - "crystal", - "validated", - "heterodimers", - "generative", + "different", + "respect", + "scales", + "three", "application", - "set", - "retraining", - "increasingly", - "design", - "produced", - "applicability", - "structures", - "protein", - "microscopy", + "without", + "1000", "synthetic", + "sizes", + "report", + "retraining", + "machine", + "pipeline", + "also", + "functions", + "relaxed", "interactions", - "offers", - "respect", + "protein", + "maps", + "optimization", + "performance", + "designability", + "amino", + "approach", "validate", - "space", + "proteins", + "comprising", "across", - "dominating", - "three", + "accuracy", + "broad", + "produced", + "microscopy", + "validated", + "novo", "sequence", - "maps", - "scalability", - "form", - "comprising", - "backbones", - "learning", - "field", + "applicability", + "scope", + "acids", + "increasingly", + "pipelines", + "two", + "generative", + "density", + "crystal", + "attractive", "ml", - "pipeline", - "need", - "machine" + "dominating", + "100", + "method", + "set", + "advanced" ], "release_date":"2024-10-16", "publication":"\"Scalable protein design using optimization in a relaxed sequence space\", Science, 386, 439-445", @@ -986758,9 +991423,9 @@ ], "subtitle":"Darpin egfp complex dp1 (3g190.24)", "tags":[ - "darpin", "protein binding", - "gfp" + "gfp", + "darpin" ], "keywords":[ "description", @@ -986809,19 +991474,19 @@ }, { "sim":273.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":273.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":273.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":273.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":273.0, @@ -986829,35 +991494,35 @@ }, { "sim":273.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":273.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":273.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":273.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":273.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":273.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":273.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":273.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":267.0, @@ -986897,11 +991562,11 @@ }, { "sim":257.0, - "partner":"7z72" + "partner":"7z71" }, { "sim":257.0, - "partner":"7z71" + "partner":"7z72" }, { "sim":257.0, @@ -986913,11 +991578,11 @@ }, { "sim":256.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":256.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":255.0, @@ -987025,7 +991690,7 @@ }, { "sim":223.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":223.0, @@ -987033,7 +991698,7 @@ }, { "sim":223.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":222.0, @@ -987069,11 +991734,11 @@ }, { "sim":213.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":213.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":213.0, @@ -987085,11 +991750,11 @@ }, { "sim":196.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":196.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":194.0, @@ -987111,6 +991776,10 @@ "sim":189.0, "partner":"8rci" }, + { + "sim":188.0, + "partner":"9glq" + }, { "sim":188.0, "partner":"2jab" @@ -987173,30 +991842,18 @@ "sim":273.0, "partner":"6bbn" }, - { - "sim":273.0, - "partner":"7yz0" - }, { "sim":273.0, "partner":"6mzf" }, { "sim":273.0, - "partner":"7yz1" - }, - { - "sim":273.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":273.0, "partner":"5nqt" }, - { - "sim":273.0, - "partner":"6mze" - }, { "sim":273.0, "partner":"7yz2" @@ -987207,11 +991864,11 @@ }, { "sim":273.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":273.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":273.0, @@ -987221,13 +991878,17 @@ "sim":273.0, "partner":"7yz5" }, + { + "sim":273.0, + "partner":"7yz6" + }, { "sim":273.0, "partner":"4lnu" }, { "sim":273.0, - "partner":"7yz6" + "partner":"6zwb" }, { "sim":273.0, @@ -987241,10 +991902,6 @@ "sim":273.0, "partner":"5nm5" }, - { - "sim":273.0, - "partner":"6zwb" - }, { "sim":273.0, "partner":"6zwc" @@ -987257,6 +991914,18 @@ "sim":273.0, "partner":"7yyz" }, + { + "sim":273.0, + "partner":"7yz0" + }, + { + "sim":273.0, + "partner":"7yz1" + }, + { + "sim":273.0, + "partner":"7z01" + }, { "sim":272.0, "partner":"7mxi" @@ -987287,11 +991956,11 @@ }, { "sim":269.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":269.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":269.0, @@ -987343,11 +992012,11 @@ }, { "sim":265.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":265.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":265.0, @@ -987433,45 +992102,25 @@ "sim":258.0, "partner":"6fp7" }, - { - "sim":258.0, - "partner":"5eno" - }, - { - "sim":258.0, - "partner":"6zob" - }, - { - "sim":258.0, - "partner":"6zo5" - }, { "sim":258.0, "partner":"4dx6" }, { "sim":258.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":258.0, "partner":"6zoc" }, - { - "sim":258.0, - "partner":"5enp" - }, - { - "sim":258.0, - "partner":"6sgs" - }, { "sim":258.0, "partner":"6zo6" }, { "sim":258.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":258.0, @@ -987479,7 +992128,7 @@ }, { "sim":258.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":258.0, @@ -987487,11 +992136,11 @@ }, { "sim":258.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":258.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":258.0, @@ -987501,6 +992150,10 @@ "sim":258.0, "partner":"6zoe" }, + { + "sim":258.0, + "partner":"5enq" + }, { "sim":258.0, "partner":"6q4p" @@ -987511,19 +992164,19 @@ }, { "sim":258.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":258.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":258.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":258.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":258.0, @@ -987535,23 +992188,23 @@ }, { "sim":258.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":258.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":258.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":258.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":258.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":258.0, @@ -987563,15 +992216,15 @@ }, { "sim":258.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":258.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":258.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":258.0, @@ -987579,15 +992232,19 @@ }, { "sim":258.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":258.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":258.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":258.0, + "partner":"6sgr" }, { "sim":258.0, @@ -987603,12 +992260,24 @@ }, { "sim":258.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":258.0, "partner":"4dx5" }, + { + "sim":258.0, + "partner":"5eno" + }, + { + "sim":258.0, + "partner":"6zo5" + }, + { + "sim":258.0, + "partner":"6q4n" + }, { "sim":258.0, "partner":"6fp8" @@ -987667,11 +992336,11 @@ }, { "sim":252.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":252.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":252.0, @@ -987721,10 +992390,6 @@ "sim":248.0, "partner":"5fio" }, - { - "sim":246.0, - "partner":"8tzb" - }, { "sim":246.0, "partner":"8tzc" @@ -987741,6 +992406,10 @@ "sim":246.0, "partner":"8tzh" }, + { + "sim":246.0, + "partner":"8tzb" + }, { "sim":246.0, "partner":"6qev" @@ -987761,10 +992430,6 @@ "sim":244.0, "partner":"6qfk" }, - { - "sim":243.0, - "partner":"8g4f" - }, { "sim":243.0, "partner":"8g42" @@ -987781,6 +992446,10 @@ "sim":243.0, "partner":"8g3k" }, + { + "sim":243.0, + "partner":"8g4f" + }, { "sim":243.0, "partner":"5lel" @@ -987827,11 +992496,11 @@ }, { "sim":236.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":236.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":236.0, @@ -987859,11 +992528,11 @@ }, { "sim":229.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":229.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":229.0, @@ -987981,10 +992650,6 @@ "sim":199.0, "partner":"2y0b" }, - { - "sim":196.0, - "partner":"7pd8" - }, { "sim":196.0, "partner":"7pdd" @@ -987997,6 +992662,10 @@ "sim":196.0, "partner":"7pdh" }, + { + "sim":196.0, + "partner":"7pd8" + }, { "sim":194.0, "partner":"6d66" @@ -988131,23 +992800,23 @@ }, { "sim":115.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":115.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":115.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":115.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":115.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":115.0, @@ -988155,11 +992824,11 @@ }, { "sim":115.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":115.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":115.0, @@ -988257,17 +992926,13 @@ "sim":103.0, "partner":"6len" }, - { - "sim":103.0, - "partner":"8q7r" - }, { "sim":103.0, "partner":"8pql" }, { - "sim":102.0, - "partner":"4cym" + "sim":103.0, + "partner":"8q7r" }, { "sim":102.0, @@ -988275,7 +992940,7 @@ }, { "sim":102.0, - "partner":"5vhj" + "partner":"4cym" }, { "sim":102.0, @@ -988307,15 +992972,15 @@ }, { "sim":102.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":102.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":102.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":102.0, @@ -988325,6 +992990,10 @@ "sim":102.0, "partner":"7vxw" }, + { + "sim":102.0, + "partner":"1uoh" + }, { "sim":102.0, "partner":"7vy4" @@ -988335,11 +993004,11 @@ }, { "sim":102.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":102.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":102.0, @@ -988363,15 +993032,15 @@ }, { "sim":101.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":101.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":101.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":99.0, @@ -988423,16 +993092,24 @@ }, { "sim":96.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":96.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":96.0, "partner":"7roy" }, + { + "sim":96.0, + "partner":"8wqg" + }, + { + "sim":96.0, + "partner":"8wqe" + }, { "sim":96.0, "partner":"8wqh" @@ -988461,14 +993138,6 @@ "sim":96.0, "partner":"8wqd" }, - { - "sim":96.0, - "partner":"8wqg" - }, - { - "sim":96.0, - "partner":"8wqe" - }, { "sim":96.0, "partner":"8je1" @@ -988779,19 +993448,19 @@ }, { "sim":76.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":76.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":76.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":76.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":76.0, @@ -988813,10 +993482,6 @@ "sim":76.0, "partner":"6wj5" }, - { - "sim":76.0, - "partner":"6v9x" - }, { "sim":76.0, "partner":"6v9y" @@ -988829,6 +993494,10 @@ "sim":76.0, "partner":"6v9w" }, + { + "sim":76.0, + "partner":"6v9x" + }, { "sim":76.0, "partner":"7or0" @@ -988905,10 +993574,6 @@ "sim":74.0, "partner":"5wo6" }, - { - "sim":74.0, - "partner":"5iwr" - }, { "sim":74.0, "partner":"5iwt" @@ -988963,15 +993628,15 @@ }, { "sim":74.0, - "partner":"5wo7" + "partner":"5iwr" }, { - "sim":73.0, - "partner":"1yyh" + "sim":74.0, + "partner":"5wo7" }, { "sim":73.0, - "partner":"6o1p" + "partner":"1yyh" }, { "sim":73.0, @@ -989011,11 +993676,7 @@ }, { "sim":73.0, - "partner":"7t6m" - }, - { - "sim":73.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":73.0, @@ -989051,15 +993712,19 @@ }, { "sim":73.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":73.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":73.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":73.0, + "partner":"7t6k" }, { "sim":73.0, @@ -989067,7 +993732,7 @@ }, { "sim":73.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":73.0, @@ -989075,7 +993740,11 @@ }, { "sim":73.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":73.0, + "partner":"8ffn" }, { "sim":72.0, @@ -989101,14 +993770,6 @@ "sim":72.0, "partner":"1wg0" }, - { - "sim":72.0, - "partner":"6m11" - }, - { - "sim":72.0, - "partner":"6m12" - }, { "sim":72.0, "partner":"6m13" @@ -989134,8 +993795,12 @@ "partner":"4o1p" }, { - "sim":71.0, - "partner":"2a5e" + "sim":72.0, + "partner":"6m11" + }, + { + "sim":72.0, + "partner":"6m12" }, { "sim":71.0, @@ -989147,16 +993812,20 @@ }, { "sim":71.0, - "partner":"7ozt" + "partner":"2a5e" }, { "sim":71.0, - "partner":"1k1a" + "partner":"7ozt" }, { "sim":71.0, "partner":"1k1b" }, + { + "sim":71.0, + "partner":"1k1a" + }, { "sim":70.0, "partner":"5z2n" @@ -989201,10 +993870,6 @@ "sim":67.0, "partner":"8sp8" }, - { - "sim":67.0, - "partner":"7k4a" - }, { "sim":67.0, "partner":"7k4b" @@ -989227,7 +993892,7 @@ }, { "sim":67.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":67.0, @@ -989243,7 +993908,7 @@ }, { "sim":67.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":67.0, @@ -989255,7 +993920,7 @@ }, { "sim":67.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":67.0, @@ -989273,6 +993938,10 @@ "sim":67.0, "partner":"6bo8" }, + { + "sim":67.0, + "partner":"6bo9" + }, { "sim":66.0, "partner":"8qfb" @@ -989618,9 +994287,9 @@ ], "subtitle":"Darpin egfp complex dp2 (2g156)", "tags":[ - "darpin", "protein binding", - "gfp" + "gfp", + "darpin" ], "keywords":[ "description", @@ -989665,11 +994334,11 @@ }, { "sim":216.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":216.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":214.0, @@ -989677,19 +994346,19 @@ }, { "sim":214.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":214.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":214.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":214.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":214.0, @@ -989697,35 +994366,35 @@ }, { "sim":214.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":214.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":214.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":214.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":214.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":214.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":214.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":214.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":212.0, @@ -989741,11 +994410,11 @@ }, { "sim":210.0, - "partner":"4j7w" + "partner":"7dnf" }, { "sim":210.0, - "partner":"7dnf" + "partner":"4j7w" }, { "sim":210.0, @@ -989805,11 +994474,11 @@ }, { "sim":198.0, - "partner":"5lw2" + "partner":"5knh" }, { "sim":198.0, - "partner":"5knh" + "partner":"5lw2" }, { "sim":197.0, @@ -989851,6 +994520,10 @@ "sim":192.0, "partner":"8aiw" }, + { + "sim":191.0, + "partner":"9glq" + }, { "sim":191.0, "partner":"8ve7" @@ -989929,7 +994602,7 @@ }, { "sim":173.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":173.0, @@ -989937,7 +994610,7 @@ }, { "sim":173.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":172.0, @@ -989957,11 +994630,11 @@ }, { "sim":170.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":170.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":170.0, @@ -989997,15 +994670,15 @@ }, { "sim":128.0, - "partner":"4gpm" + "partner":"5hry" }, { "sim":128.0, - "partner":"5hry" + "partner":"4hb5" }, { "sim":128.0, - "partner":"4hb5" + "partner":"4gpm" }, { "sim":123.0, @@ -990043,11 +994716,11 @@ }, { "sim":222.0, - "partner":"3zuv" + "partner":"8ipf" }, { "sim":222.0, - "partner":"8ipf" + "partner":"3zuv" }, { "sim":221.0, @@ -990073,10 +994746,6 @@ "sim":218.0, "partner":"7mxi" }, - { - "sim":218.0, - "partner":"7pd8" - }, { "sim":218.0, "partner":"7pdd" @@ -990089,6 +994758,10 @@ "sim":218.0, "partner":"7pdh" }, + { + "sim":218.0, + "partner":"7pd8" + }, { "sim":218.0, "partner":"7alr" @@ -990101,30 +994774,18 @@ "sim":214.0, "partner":"6bbn" }, - { - "sim":214.0, - "partner":"7yz0" - }, { "sim":214.0, "partner":"6mzf" }, { "sim":214.0, - "partner":"7yz1" - }, - { - "sim":214.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":214.0, "partner":"5nqt" }, - { - "sim":214.0, - "partner":"6mze" - }, { "sim":214.0, "partner":"7yz2" @@ -990135,11 +994796,11 @@ }, { "sim":214.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":214.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":214.0, @@ -990149,13 +994810,17 @@ "sim":214.0, "partner":"7yz5" }, + { + "sim":214.0, + "partner":"7yz6" + }, { "sim":214.0, "partner":"4lnu" }, { "sim":214.0, - "partner":"7yz6" + "partner":"6zwb" }, { "sim":214.0, @@ -990169,10 +994834,6 @@ "sim":214.0, "partner":"5nm5" }, - { - "sim":214.0, - "partner":"6zwb" - }, { "sim":214.0, "partner":"6zwc" @@ -990185,6 +994846,18 @@ "sim":214.0, "partner":"7yyz" }, + { + "sim":214.0, + "partner":"7yz0" + }, + { + "sim":214.0, + "partner":"7yz1" + }, + { + "sim":214.0, + "partner":"7z01" + }, { "sim":213.0, "partner":"6d66" @@ -990211,11 +994884,11 @@ }, { "sim":210.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":210.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":210.0, @@ -990279,11 +994952,11 @@ }, { "sim":207.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":207.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":207.0, @@ -990317,10 +994990,6 @@ "sim":205.0, "partner":"6s9t" }, - { - "sim":205.0, - "partner":"5oyj" - }, { "sim":205.0, "partner":"2p2c" @@ -990333,6 +995002,10 @@ "sim":205.0, "partner":"6d65" }, + { + "sim":205.0, + "partner":"5oyj" + }, { "sim":205.0, "partner":"5cbn" @@ -990363,11 +995036,11 @@ }, { "sim":203.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":203.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":203.0, @@ -990405,45 +995078,25 @@ "sim":201.0, "partner":"6fp8" }, - { - "sim":200.0, - "partner":"5eno" - }, - { - "sim":200.0, - "partner":"6zob" - }, - { - "sim":200.0, - "partner":"6zo5" - }, { "sim":200.0, "partner":"4dx6" }, { "sim":200.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":200.0, "partner":"6zoc" }, - { - "sim":200.0, - "partner":"5enp" - }, - { - "sim":200.0, - "partner":"6sgs" - }, { "sim":200.0, "partner":"6zo6" }, { "sim":200.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":200.0, @@ -990451,7 +995104,7 @@ }, { "sim":200.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":200.0, @@ -990459,11 +995112,11 @@ }, { "sim":200.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":200.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":200.0, @@ -990473,6 +995126,10 @@ "sim":200.0, "partner":"6zoe" }, + { + "sim":200.0, + "partner":"5enq" + }, { "sim":200.0, "partner":"6q4p" @@ -990483,19 +995140,19 @@ }, { "sim":200.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":200.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":200.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":200.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":200.0, @@ -990507,23 +995164,23 @@ }, { "sim":200.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":200.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":200.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":200.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":200.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":200.0, @@ -990535,15 +995192,15 @@ }, { "sim":200.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":200.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":200.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":200.0, @@ -990551,15 +995208,19 @@ }, { "sim":200.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":200.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":200.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":200.0, + "partner":"6sgr" }, { "sim":200.0, @@ -990575,12 +995236,24 @@ }, { "sim":200.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":200.0, "partner":"4dx5" }, + { + "sim":200.0, + "partner":"5eno" + }, + { + "sim":200.0, + "partner":"6zo5" + }, + { + "sim":200.0, + "partner":"6q4n" + }, { "sim":200.0, "partner":"5mla" @@ -990657,10 +995330,6 @@ "sim":193.0, "partner":"6mof" }, - { - "sim":193.0, - "partner":"8tzb" - }, { "sim":193.0, "partner":"8tzc" @@ -990677,6 +995346,10 @@ "sim":193.0, "partner":"8tzh" }, + { + "sim":193.0, + "partner":"8tzb" + }, { "sim":192.0, "partner":"4k5c" @@ -990741,10 +995414,6 @@ "sim":186.0, "partner":"5itz" }, - { - "sim":186.0, - "partner":"8g4f" - }, { "sim":186.0, "partner":"8g42" @@ -990761,6 +995430,10 @@ "sim":186.0, "partner":"8g3k" }, + { + "sim":186.0, + "partner":"8g4f" + }, { "sim":185.0, "partner":"6f5e" @@ -990779,11 +995452,11 @@ }, { "sim":181.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":181.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":180.0, @@ -990795,11 +995468,11 @@ }, { "sim":179.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":179.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":179.0, @@ -990923,23 +995596,23 @@ }, { "sim":98.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":98.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":98.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":98.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":98.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":98.0, @@ -990947,11 +995620,11 @@ }, { "sim":98.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":98.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":98.0, @@ -991103,11 +995776,11 @@ }, { "sim":85.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":85.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":85.0, @@ -991131,19 +995804,19 @@ }, { "sim":82.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":82.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":82.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":82.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":81.0, @@ -991163,11 +995836,11 @@ }, { "sim":80.0, - "partner":"1ap7" + "partner":"1mx6" }, { "sim":80.0, - "partner":"1mx6" + "partner":"1ap7" }, { "sim":80.0, @@ -991209,10 +995882,6 @@ "sim":78.0, "partner":"1nfi" }, - { - "sim":78.0, - "partner":"5vhj" - }, { "sim":78.0, "partner":"5vhh" @@ -991243,15 +995912,15 @@ }, { "sim":78.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":78.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":78.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":78.0, @@ -991261,6 +995930,10 @@ "sim":78.0, "partner":"7vxw" }, + { + "sim":78.0, + "partner":"1uoh" + }, { "sim":78.0, "partner":"7vy4" @@ -991271,11 +995944,11 @@ }, { "sim":78.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":78.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":78.0, @@ -991287,15 +995960,15 @@ }, { "sim":78.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":78.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":78.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":78.0, @@ -991411,11 +996084,11 @@ }, { "sim":71.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":71.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":71.0, @@ -991423,16 +996096,24 @@ }, { "sim":71.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":71.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":71.0, "partner":"7roy" }, + { + "sim":71.0, + "partner":"8wqg" + }, + { + "sim":71.0, + "partner":"8wqe" + }, { "sim":71.0, "partner":"8wqh" @@ -991461,14 +996142,6 @@ "sim":71.0, "partner":"8wqd" }, - { - "sim":71.0, - "partner":"8wqg" - }, - { - "sim":71.0, - "partner":"8wqe" - }, { "sim":71.0, "partner":"8je1" @@ -991587,15 +996260,15 @@ }, { "sim":68.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":68.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":68.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":68.0, @@ -991705,10 +996378,6 @@ "sim":61.0, "partner":"4ot9" }, - { - "sim":61.0, - "partner":"6o1p" - }, { "sim":61.0, "partner":"6b5v" @@ -991747,11 +996416,7 @@ }, { "sim":61.0, - "partner":"7t6m" - }, - { - "sim":61.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":61.0, @@ -991787,15 +996452,19 @@ }, { "sim":61.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":61.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":61.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":61.0, + "partner":"7t6k" }, { "sim":61.0, @@ -991803,7 +996472,7 @@ }, { "sim":61.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":61.0, @@ -991811,7 +996480,11 @@ }, { "sim":61.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":61.0, + "partner":"8ffn" }, { "sim":60.0, @@ -991863,11 +996536,11 @@ }, { "sim":59.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":59.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":59.0, @@ -991881,10 +996554,6 @@ "sim":59.0, "partner":"5wo6" }, - { - "sim":59.0, - "partner":"5iwr" - }, { "sim":59.0, "partner":"5iwt" @@ -991939,15 +996608,15 @@ }, { "sim":59.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":59.0, - "partner":"6e2g" + "partner":"5wo7" }, { "sim":59.0, - "partner":"6v9x" + "partner":"6e2g" }, { "sim":59.0, @@ -991961,6 +996630,10 @@ "sim":59.0, "partner":"6v9w" }, + { + "sim":59.0, + "partner":"6v9x" + }, { "sim":59.0, "partner":"7or0" @@ -992053,10 +996726,6 @@ "sim":53.0, "partner":"8sp8" }, - { - "sim":53.0, - "partner":"7k4a" - }, { "sim":53.0, "partner":"7k4b" @@ -992079,7 +996748,7 @@ }, { "sim":53.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":53.0, @@ -992095,7 +996764,7 @@ }, { "sim":53.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":53.0, @@ -992107,7 +996776,7 @@ }, { "sim":53.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":53.0, @@ -992125,6 +996794,10 @@ "sim":53.0, "partner":"6bo8" }, + { + "sim":53.0, + "partner":"6bo9" + }, { "sim":52.0, "partner":"3deo" @@ -992230,9 +996903,9 @@ ], "subtitle":"Darpin egfp complex dp4 (2g71)", "tags":[ - "darpin", "protein binding", - "gfp" + "gfp", + "darpin" ], "keywords":[ "description", @@ -992277,19 +996950,19 @@ }, { "sim":206.0, - "partner":"8qla" + "partner":"8ql3" }, { "sim":206.0, - "partner":"8qea" + "partner":"9f8g" }, { "sim":206.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":206.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":206.0, @@ -992297,35 +996970,35 @@ }, { "sim":206.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":206.0, - "partner":"9f8g" + "partner":"8qea" }, { "sim":206.0, - "partner":"8ql6" + "partner":"8qlb" }, { "sim":206.0, - "partner":"8ql5" + "partner":"8ql9" }, { "sim":206.0, - "partner":"8ql4" + "partner":"8ql7" }, { "sim":206.0, - "partner":"8ql7" + "partner":"8ql4" }, { "sim":206.0, - "partner":"8qlb" + "partner":"8ql2" }, { "sim":206.0, - "partner":"8ql2" + "partner":"8ql5" }, { "sim":205.0, @@ -992333,11 +997006,11 @@ }, { "sim":205.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":205.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":203.0, @@ -992381,11 +997054,11 @@ }, { "sim":193.0, - "partner":"7z72" + "partner":"7z71" }, { "sim":193.0, - "partner":"7z71" + "partner":"7z72" }, { "sim":193.0, @@ -992447,6 +997120,10 @@ "sim":188.0, "partner":"5knh" }, + { + "sim":187.0, + "partner":"9glq" + }, { "sim":187.0, "partner":"5lw2" @@ -992457,11 +997134,11 @@ }, { "sim":183.0, - "partner":"7dne" + "partner":"2xee" }, { "sim":183.0, - "partner":"2xee" + "partner":"7dne" }, { "sim":183.0, @@ -992537,7 +997214,7 @@ }, { "sim":168.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":168.0, @@ -992545,7 +997222,7 @@ }, { "sim":168.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":166.0, @@ -992577,11 +997254,11 @@ }, { "sim":161.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":161.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":161.0, @@ -992681,10 +997358,6 @@ "sim":207.0, "partner":"2v4h" }, - { - "sim":207.0, - "partner":"7pd8" - }, { "sim":207.0, "partner":"7pdd" @@ -992699,15 +997372,15 @@ }, { "sim":207.0, - "partner":"6h46" + "partner":"7pd8" }, { - "sim":206.0, - "partner":"6bbn" + "sim":207.0, + "partner":"6h46" }, { "sim":206.0, - "partner":"7yz0" + "partner":"6bbn" }, { "sim":206.0, @@ -992715,20 +997388,12 @@ }, { "sim":206.0, - "partner":"7yz1" - }, - { - "sim":206.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":206.0, "partner":"5nqt" }, - { - "sim":206.0, - "partner":"6mze" - }, { "sim":206.0, "partner":"7yz2" @@ -992739,11 +997404,11 @@ }, { "sim":206.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":206.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":206.0, @@ -992753,13 +997418,17 @@ "sim":206.0, "partner":"7yz5" }, + { + "sim":206.0, + "partner":"7yz6" + }, { "sim":206.0, "partner":"4lnu" }, { "sim":206.0, - "partner":"7yz6" + "partner":"6zwb" }, { "sim":206.0, @@ -992773,10 +997442,6 @@ "sim":206.0, "partner":"5nm5" }, - { - "sim":206.0, - "partner":"6zwb" - }, { "sim":206.0, "partner":"6zwc" @@ -992789,6 +997454,18 @@ "sim":206.0, "partner":"7yyz" }, + { + "sim":206.0, + "partner":"7yz0" + }, + { + "sim":206.0, + "partner":"7yz1" + }, + { + "sim":206.0, + "partner":"7z01" + }, { "sim":205.0, "partner":"3hg0" @@ -992835,11 +997512,11 @@ }, { "sim":201.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":201.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":201.0, @@ -992851,11 +997528,11 @@ }, { "sim":201.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":201.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":201.0, @@ -992887,11 +997564,11 @@ }, { "sim":199.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":199.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":199.0, @@ -992907,11 +997584,11 @@ }, { "sim":199.0, - "partner":"4f6r" + "partner":"6gvn" }, { "sim":199.0, - "partner":"6gvn" + "partner":"4f6r" }, { "sim":199.0, @@ -992971,11 +997648,11 @@ }, { "sim":196.0, - "partner":"4k5b" + "partner":"6d65" }, { "sim":196.0, - "partner":"6d65" + "partner":"4k5b" }, { "sim":196.0, @@ -993069,45 +997746,25 @@ "sim":190.0, "partner":"8dw3" }, - { - "sim":190.0, - "partner":"5eno" - }, - { - "sim":190.0, - "partner":"6zob" - }, - { - "sim":190.0, - "partner":"6zo5" - }, { "sim":190.0, "partner":"4dx6" }, { "sim":190.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":190.0, "partner":"6zoc" }, - { - "sim":190.0, - "partner":"5enp" - }, - { - "sim":190.0, - "partner":"6sgs" - }, { "sim":190.0, "partner":"6zo6" }, { "sim":190.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":190.0, @@ -993115,7 +997772,7 @@ }, { "sim":190.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":190.0, @@ -993123,11 +997780,11 @@ }, { "sim":190.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":190.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":190.0, @@ -993137,6 +997794,10 @@ "sim":190.0, "partner":"6zoe" }, + { + "sim":190.0, + "partner":"5enq" + }, { "sim":190.0, "partner":"6q4p" @@ -993147,19 +997808,19 @@ }, { "sim":190.0, - "partner":"7ouk" + "partner":"7b8s" }, { "sim":190.0, - "partner":"2j8s" + "partner":"7ouk" }, { "sim":190.0, - "partner":"4u96" + "partner":"2j8s" }, { "sim":190.0, - "partner":"7b8s" + "partner":"4u96" }, { "sim":190.0, @@ -993171,23 +997832,23 @@ }, { "sim":190.0, - "partner":"5enr" + "partner":"6sgu" }, { "sim":190.0, - "partner":"4u8v" + "partner":"5enr" }, { "sim":190.0, - "partner":"6sgu" + "partner":"7oul" }, { "sim":190.0, - "partner":"7oul" + "partner":"4u8v" }, { "sim":190.0, - "partner":"5nc5" + "partner":"7b8t" }, { "sim":190.0, @@ -993199,15 +997860,15 @@ }, { "sim":190.0, - "partner":"7b8t" + "partner":"5nc5" }, { "sim":190.0, - "partner":"5ens" + "partner":"7oum" }, { "sim":190.0, - "partner":"7oum" + "partner":"5ens" }, { "sim":190.0, @@ -993215,15 +997876,19 @@ }, { "sim":190.0, - "partner":"4u8y" + "partner":"6zoa" }, { "sim":190.0, - "partner":"6zoa" + "partner":"6zoh" }, { "sim":190.0, - "partner":"6zoh" + "partner":"4u8y" + }, + { + "sim":190.0, + "partner":"6sgr" }, { "sim":190.0, @@ -993239,12 +997904,24 @@ }, { "sim":190.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":190.0, "partner":"4dx5" }, + { + "sim":190.0, + "partner":"5eno" + }, + { + "sim":190.0, + "partner":"6zo5" + }, + { + "sim":190.0, + "partner":"6q4n" + }, { "sim":190.0, "partner":"5h76" @@ -993305,10 +997982,6 @@ "sim":183.0, "partner":"6mzg" }, - { - "sim":182.0, - "partner":"8g4f" - }, { "sim":182.0, "partner":"8g42" @@ -993325,6 +997998,10 @@ "sim":182.0, "partner":"8g3k" }, + { + "sim":182.0, + "partner":"8g4f" + }, { "sim":182.0, "partner":"6qev" @@ -993337,10 +998014,6 @@ "sim":181.0, "partner":"4ydy" }, - { - "sim":181.0, - "partner":"8tzb" - }, { "sim":181.0, "partner":"8tzc" @@ -993357,6 +998030,10 @@ "sim":181.0, "partner":"8tzh" }, + { + "sim":181.0, + "partner":"8tzb" + }, { "sim":181.0, "partner":"5aq9" @@ -993371,11 +998048,11 @@ }, { "sim":177.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":177.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":177.0, @@ -993427,11 +998104,11 @@ }, { "sim":171.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":171.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":171.0, @@ -993607,19 +998284,19 @@ }, { "sim":85.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":85.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":85.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":85.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":85.0, @@ -993635,23 +998312,23 @@ }, { "sim":85.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":85.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":85.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":85.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":85.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":85.0, @@ -993659,11 +998336,11 @@ }, { "sim":85.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":85.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":85.0, @@ -993751,11 +998428,11 @@ }, { "sim":83.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":83.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":82.0, @@ -993877,10 +998554,6 @@ "sim":78.0, "partner":"5eid" }, - { - "sim":78.0, - "partner":"5vhj" - }, { "sim":78.0, "partner":"5vhh" @@ -993911,15 +998584,15 @@ }, { "sim":78.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":78.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":78.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":78.0, @@ -993929,6 +998602,10 @@ "sim":78.0, "partner":"7vxw" }, + { + "sim":78.0, + "partner":"1uoh" + }, { "sim":78.0, "partner":"7vy4" @@ -993939,11 +998616,11 @@ }, { "sim":78.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":78.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":78.0, @@ -993955,15 +998632,15 @@ }, { "sim":78.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":78.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":78.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":78.0, @@ -993983,16 +998660,24 @@ }, { "sim":78.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":78.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":78.0, "partner":"7roy" }, + { + "sim":78.0, + "partner":"8wqg" + }, + { + "sim":78.0, + "partner":"8wqe" + }, { "sim":78.0, "partner":"8wqh" @@ -994021,14 +998706,6 @@ "sim":78.0, "partner":"8wqd" }, - { - "sim":78.0, - "partner":"8wqg" - }, - { - "sim":78.0, - "partner":"8wqe" - }, { "sim":78.0, "partner":"8je1" @@ -994043,11 +998720,11 @@ }, { "sim":76.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":76.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":75.0, @@ -994219,15 +998896,15 @@ }, { "sim":65.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":65.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":65.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":65.0, @@ -994293,10 +998970,6 @@ "sim":63.0, "partner":"4ot9" }, - { - "sim":63.0, - "partner":"6v9x" - }, { "sim":63.0, "partner":"6v9y" @@ -994309,6 +998982,10 @@ "sim":63.0, "partner":"6v9w" }, + { + "sim":63.0, + "partner":"6v9x" + }, { "sim":63.0, "partner":"7or0" @@ -994405,14 +999082,6 @@ "sim":60.0, "partner":"6wj5" }, - { - "sim":60.0, - "partner":"6m11" - }, - { - "sim":60.0, - "partner":"6m12" - }, { "sim":60.0, "partner":"6m13" @@ -994437,6 +999106,14 @@ "sim":60.0, "partner":"4o1p" }, + { + "sim":60.0, + "partner":"6m11" + }, + { + "sim":60.0, + "partner":"6m12" + }, { "sim":60.0, "partner":"7ykr" @@ -994483,11 +999160,11 @@ }, { "sim":57.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":57.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":57.0, @@ -994505,10 +999182,6 @@ "sim":57.0, "partner":"5wo6" }, - { - "sim":57.0, - "partner":"5iwr" - }, { "sim":57.0, "partner":"5iwt" @@ -994561,6 +999234,10 @@ "sim":57.0, "partner":"5iwp" }, + { + "sim":57.0, + "partner":"5iwr" + }, { "sim":57.0, "partner":"5wo7" @@ -994585,10 +999262,6 @@ "sim":56.0, "partner":"4bet" }, - { - "sim":56.0, - "partner":"6o1p" - }, { "sim":56.0, "partner":"6b5v" @@ -994627,11 +999300,7 @@ }, { "sim":56.0, - "partner":"7t6m" - }, - { - "sim":56.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":56.0, @@ -994667,15 +999336,19 @@ }, { "sim":56.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":56.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":56.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":56.0, + "partner":"7t6k" }, { "sim":56.0, @@ -994683,7 +999356,7 @@ }, { "sim":56.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":56.0, @@ -994691,7 +999364,11 @@ }, { "sim":56.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":56.0, + "partner":"8ffn" }, { "sim":56.0, @@ -994761,10 +999438,6 @@ "sim":50.0, "partner":"8sp8" }, - { - "sim":50.0, - "partner":"7k4a" - }, { "sim":50.0, "partner":"7k4b" @@ -994787,7 +999460,7 @@ }, { "sim":50.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":50.0, @@ -994803,7 +999476,7 @@ }, { "sim":50.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":50.0, @@ -994815,7 +999488,7 @@ }, { "sim":50.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":50.0, @@ -994832,6 +999505,10 @@ { "sim":50.0, "partner":"6bo8" + }, + { + "sim":50.0, + "partner":"6bo9" } ], "struct_thr_sim_designed":[ @@ -994976,116 +999653,116 @@ "subtitle":"Photostatin (photoswitchable azo-combretastatin) z-pst27 bound to tubulin-darpin d1 complex", "tags":[ "tubulin polymerisation inhibitor", - "photopharmacology", "sensitisation", + "photopharmacology", "antimitotics", - "microtubule dynamics", "photoswitch", + "microtubule dynamics", "cell cycle" ], "keywords":[ + "molecular", + "redesign", "tune", - "cargos", + "structural", + "subsecond", "spatial", - "fluorophores", - "azobenzene", - "bioactivity", - "unknown", - "remained", - "results", - "link", - "synthesised", - "ret", - "use", - "imaging", - "potent", - "inhibitor", - "time", - "enhance", + "precision", "microtubule", - "broad", - "towards", - "instead", - "expand", + "inhibitor", + "results", + "new", + "drive", "photoswitchable", - "identifying", - "redesign", - "minimal", - "inhibitors", - "however", - "photoswitching", - "novel", - "general", - "photoresponse", - "reversible", - "greatly", + "probes", "reporter", "untested", - "response", - "aiming", - "subsecond", - "onset", - "used", - "furthermore", - "antennas", - "drive", - "dynamics", - "living", - "tolerated", + "wavelengths", + "identifying", + "together", + "bioactivity", + "general", + "cells", + "systems", + "scope", + "applications", "attach", - "function", - "tubulin", "effects", - "systems", + "live", + "unknown", + "a4", + "photoisomerisation", "embryos", - "exploring", - "previously", - "scope", + "taken", + "however", "psts", + "enhance", + "furthermore", + "identified", + "ret", + "cargos", "control", - "taken", - "molecular", - "functional", - "guide", - "sufficiently", - "linkers", - "temporal", + "azobenzene", + "exploring", + "modifications", + "response", + "sites", + "broad", + "use", "tandem", - "situ", - "optically", + "found", + "antennas", + "tolerated", + "sufficiently", + "aiming", "design", - "live", "isomerisation", - "applications", - "progress", - "lipophilicity", - "promising", - "variations", - "polymerisation", - "cells", - "structural", - "panel", - "sites", - "a4", + "photoswitching", + "living", + "used", + "instead", + "functional", "tested", - "wavelengths", "also", - "cytostatic", - "together", - "reveal", - "precision", - "found", - "combretastatin", - "identified", - "modifications", + "reversible", "light", - "mechanism", - "analogues", - "probes", + "polymerisation", + "tubulin", + "promising", + "time", + "expand", + "photoresponse", + "lipophilicity", "developed", + "optically", + "combretastatin", + "mechanism", + "minimal", + "dynamics", + "reveal", + "fluorophores", "photopharmaceuticals", - "photoisomerisation", - "new" + "panel", + "link", + "progress", + "onset", + "previously", + "imaging", + "situ", + "cytostatic", + "inhibitors", + "function", + "linkers", + "temporal", + "synthesised", + "analogues", + "remained", + "greatly", + "towards", + "guide", + "potent", + "variations", + "novel" ], "release_date":"2024-09-04", "publication":"\"A photo-SAR study of photoswitchable azobenzene tubulin-inhibiting antimitotics identifying a general method for near-quantitative photocontrol\", Chem Sci, 15, 12301-12309", @@ -995118,19 +999795,15 @@ "seq_thr_sim_designed":[ { "sim":342.0, - "partner":"8qla" - }, - { - "sim":342.0, - "partner":"8qea" + "partner":"8ql3" }, { "sim":342.0, - "partner":"4dui" + "partner":"8ql6" }, { "sim":342.0, - "partner":"8ql9" + "partner":"8qla" }, { "sim":342.0, @@ -995138,19 +999811,19 @@ }, { "sim":342.0, - "partner":"8ql3" + "partner":"4dui" }, { "sim":342.0, - "partner":"8ql6" + "partner":"8qea" }, { "sim":342.0, - "partner":"8ql5" + "partner":"8qlb" }, { "sim":342.0, - "partner":"8ql4" + "partner":"8ql9" }, { "sim":342.0, @@ -995158,12 +999831,16 @@ }, { "sim":342.0, - "partner":"8qlb" + "partner":"8ql4" }, { "sim":342.0, "partner":"8ql2" }, + { + "sim":342.0, + "partner":"8ql5" + }, { "sim":298.0, "partner":"7dnf" @@ -995178,19 +999855,19 @@ }, { "sim":295.0, - "partner":"4j8y" + "partner":"4j7w" }, { "sim":295.0, - "partner":"4j7w" + "partner":"4j8y" }, { "sim":291.0, - "partner":"5oou" + "partner":"5op3" }, { "sim":291.0, - "partner":"5op3" + "partner":"5oou" }, { "sim":290.0, @@ -995246,11 +999923,11 @@ }, { "sim":261.0, - "partner":"7z72" + "partner":"7z7e" }, { "sim":261.0, - "partner":"7z7e" + "partner":"7z72" }, { "sim":259.0, @@ -995318,7 +999995,7 @@ }, { "sim":253.0, - "partner":"5lec" + "partner":"5lee" }, { "sim":253.0, @@ -995326,7 +1000003,7 @@ }, { "sim":253.0, - "partner":"5lee" + "partner":"5lec" }, { "sim":252.0, @@ -995382,11 +1000059,11 @@ }, { "sim":223.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":223.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":223.0, @@ -995410,11 +1000087,11 @@ }, { "sim":207.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":207.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":205.0, @@ -995426,19 +1000103,23 @@ }, { "sim":198.0, - "partner":"8rci" + "partner":"7z73" }, { "sim":198.0, - "partner":"7z73" + "partner":"8rci" }, { "sim":192.0, - "partner":"4o60" + "partner":"4qfv" }, { "sim":192.0, - "partner":"4qfv" + "partner":"4o60" + }, + { + "sim":187.0, + "partner":"9glq" }, { "sim":178.0, @@ -995486,30 +1000167,18 @@ } ], "seq_thr_sim_natural":[ - { - "sim":342.0, - "partner":"7yz0" - }, { "sim":342.0, "partner":"6mzf" }, { "sim":342.0, - "partner":"7yz1" - }, - { - "sim":342.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":342.0, "partner":"5nqt" }, - { - "sim":342.0, - "partner":"6mze" - }, { "sim":342.0, "partner":"7yz2" @@ -995520,11 +1000189,11 @@ }, { "sim":342.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":342.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":342.0, @@ -995536,23 +1000205,23 @@ }, { "sim":342.0, - "partner":"4lnu" + "partner":"7yz6" }, { "sim":342.0, - "partner":"7yz6" + "partner":"4lnu" }, { "sim":342.0, - "partner":"4drx" + "partner":"6zwb" }, { "sim":342.0, - "partner":"5nm5" + "partner":"4drx" }, { "sim":342.0, - "partner":"6zwb" + "partner":"5nm5" }, { "sim":342.0, @@ -995566,6 +1000235,18 @@ "sim":342.0, "partner":"7yyz" }, + { + "sim":342.0, + "partner":"7yz0" + }, + { + "sim":342.0, + "partner":"7yz1" + }, + { + "sim":342.0, + "partner":"7z01" + }, { "sim":338.0, "partner":"6bbn" @@ -995596,11 +1000277,11 @@ }, { "sim":315.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":315.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":312.0, @@ -995664,27 +1000345,19 @@ }, { "sim":290.0, - "partner":"5eno" - }, - { - "sim":290.0, - "partner":"6zob" - }, - { - "sim":290.0, - "partner":"6zo5" + "partner":"4dx6" }, { "sim":290.0, - "partner":"4dx6" + "partner":"6sgs" }, { "sim":290.0, - "partner":"6q4n" + "partner":"6zoc" }, { "sim":290.0, - "partner":"6zoc" + "partner":"6zo6" }, { "sim":290.0, @@ -995692,11 +1000365,11 @@ }, { "sim":290.0, - "partner":"6sgs" + "partner":"6q4o" }, { "sim":290.0, - "partner":"6zo6" + "partner":"7b8r" }, { "sim":290.0, @@ -995704,11 +1000377,11 @@ }, { "sim":290.0, - "partner":"4dx7" + "partner":"6zod" }, { "sim":290.0, - "partner":"6q4o" + "partner":"4dx7" }, { "sim":290.0, @@ -995716,11 +1000389,7 @@ }, { "sim":290.0, - "partner":"6zod" - }, - { - "sim":290.0, - "partner":"7b8r" + "partner":"6zo7" }, { "sim":290.0, @@ -995728,23 +1000397,23 @@ }, { "sim":290.0, - "partner":"5enq" + "partner":"6zoe" }, { "sim":290.0, - "partner":"6zo7" + "partner":"5enq" }, { "sim":290.0, - "partner":"6zoe" + "partner":"6q4p" }, { "sim":290.0, - "partner":"6q4p" + "partner":"6sgt" }, { "sim":290.0, - "partner":"6sgt" + "partner":"7b8s" }, { "sim":290.0, @@ -995760,24 +1000429,28 @@ }, { "sim":290.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":290.0, - "partner":"3noc" + "partner":"6zof" }, { "sim":290.0, - "partner":"6zo8" + "partner":"3noc" }, { "sim":290.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":290.0, "partner":"5enr" }, + { + "sim":290.0, + "partner":"7oul" + }, { "sim":290.0, "partner":"1svx" @@ -995788,39 +1000461,39 @@ }, { "sim":290.0, - "partner":"6sgu" + "partner":"7b8t" }, { "sim":290.0, - "partner":"7oul" + "partner":"6zo9" }, { "sim":290.0, - "partner":"5nc5" + "partner":"6zog" }, { "sim":290.0, - "partner":"6zo9" + "partner":"5nc5" }, { "sim":290.0, - "partner":"6zog" + "partner":"7oum" }, { "sim":290.0, - "partner":"7b8t" + "partner":"5ens" }, { "sim":290.0, - "partner":"5ens" + "partner":"5en5" }, { "sim":290.0, - "partner":"7oum" + "partner":"6zoa" }, { "sim":290.0, - "partner":"5en5" + "partner":"6zoh" }, { "sim":290.0, @@ -995828,11 +1000501,11 @@ }, { "sim":290.0, - "partner":"6zoa" + "partner":"6d65" }, { "sim":290.0, - "partner":"6zoh" + "partner":"6sgr" }, { "sim":290.0, @@ -995848,15 +1000521,23 @@ }, { "sim":290.0, - "partner":"6d65" + "partner":"6zob" }, { "sim":290.0, - "partner":"6sgr" + "partner":"4dx5" }, { "sim":290.0, - "partner":"4dx5" + "partner":"5eno" + }, + { + "sim":290.0, + "partner":"6zo5" + }, + { + "sim":290.0, + "partner":"6q4n" }, { "sim":289.0, @@ -995914,10 +1000595,6 @@ "sim":274.0, "partner":"6gcu" }, - { - "sim":274.0, - "partner":"8tzb" - }, { "sim":274.0, "partner":"8tzc" @@ -995934,6 +1000611,10 @@ "sim":274.0, "partner":"8tzh" }, + { + "sim":274.0, + "partner":"8tzb" + }, { "sim":274.0, "partner":"5lel" @@ -996040,11 +1000721,11 @@ }, { "sim":262.0, - "partner":"5ma4" + "partner":"5mak" }, { "sim":262.0, - "partner":"5mak" + "partner":"5ma4" }, { "sim":262.0, @@ -996092,11 +1000773,11 @@ }, { "sim":258.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":258.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":256.0, @@ -996138,10 +1000819,6 @@ "sim":247.0, "partner":"6qev" }, - { - "sim":246.0, - "partner":"8g4f" - }, { "sim":246.0, "partner":"8g42" @@ -996158,6 +1000835,10 @@ "sim":246.0, "partner":"8g3k" }, + { + "sim":246.0, + "partner":"8g4f" + }, { "sim":246.0, "partner":"6sh9" @@ -996168,11 +1000849,11 @@ }, { "sim":244.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":244.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":244.0, @@ -996184,11 +1000865,11 @@ }, { "sim":242.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":242.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":240.0, @@ -996294,10 +1000975,6 @@ "sim":228.0, "partner":"4hrn" }, - { - "sim":228.0, - "partner":"7pd8" - }, { "sim":228.0, "partner":"7pdd" @@ -996310,6 +1000987,10 @@ "sim":228.0, "partner":"7pdh" }, + { + "sim":228.0, + "partner":"7pd8" + }, { "sim":224.0, "partner":"6moj" @@ -996448,23 +1001129,23 @@ }, { "sim":119.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":119.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":119.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":119.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":119.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":119.0, @@ -996472,11 +1001153,11 @@ }, { "sim":119.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":119.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":119.0, @@ -996550,10 +1001231,6 @@ "sim":103.0, "partner":"2l6b" }, - { - "sim":103.0, - "partner":"5vhj" - }, { "sim":103.0, "partner":"5vhh" @@ -996584,15 +1001261,15 @@ }, { "sim":103.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":103.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":103.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":103.0, @@ -996602,6 +1001279,10 @@ "sim":103.0, "partner":"7vxw" }, + { + "sim":103.0, + "partner":"1uoh" + }, { "sim":103.0, "partner":"7vy4" @@ -996612,11 +1001293,11 @@ }, { "sim":103.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":103.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":103.0, @@ -996628,15 +1001309,15 @@ }, { "sim":102.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":102.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":102.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":102.0, @@ -996676,11 +1001357,11 @@ }, { "sim":102.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":102.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":100.0, @@ -996708,11 +1001389,11 @@ }, { "sim":99.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":99.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":99.0, @@ -996792,15 +1001473,15 @@ }, { "sim":91.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":91.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":91.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":91.0, @@ -996820,16 +1001501,24 @@ }, { "sim":90.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":90.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":90.0, "partner":"7roy" }, + { + "sim":90.0, + "partner":"8wqg" + }, + { + "sim":90.0, + "partner":"8wqe" + }, { "sim":90.0, "partner":"8wqh" @@ -996858,14 +1001547,6 @@ "sim":90.0, "partner":"8wqd" }, - { - "sim":90.0, - "partner":"8wqg" - }, - { - "sim":90.0, - "partner":"8wqe" - }, { "sim":90.0, "partner":"8je1" @@ -996998,10 +1001679,6 @@ "sim":84.0, "partner":"6e2g" }, - { - "sim":84.0, - "partner":"6v9x" - }, { "sim":84.0, "partner":"6v9y" @@ -997014,6 +1001691,10 @@ "sim":84.0, "partner":"6v9w" }, + { + "sim":84.0, + "partner":"6v9x" + }, { "sim":84.0, "partner":"7or0" @@ -997134,10 +1001815,6 @@ "sim":80.0, "partner":"5wo6" }, - { - "sim":80.0, - "partner":"5iwr" - }, { "sim":80.0, "partner":"5iwt" @@ -997192,11 +1001869,11 @@ }, { "sim":80.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":80.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":80.0, @@ -997236,11 +1001913,7 @@ }, { "sim":80.0, - "partner":"7t6m" - }, - { - "sim":80.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":80.0, @@ -997276,15 +1001949,19 @@ }, { "sim":80.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":80.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":80.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":80.0, + "partner":"7t6k" }, { "sim":80.0, @@ -997292,7 +1001969,7 @@ }, { "sim":80.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":80.0, @@ -997300,7 +1001977,11 @@ }, { "sim":80.0, - "partner":"7t6l" + "partner":"7t6m" + }, + { + "sim":80.0, + "partner":"8ffn" }, { "sim":79.0, @@ -997314,14 +1001995,6 @@ "sim":79.0, "partner":"6kyk" }, - { - "sim":78.0, - "partner":"3aaa" - }, - { - "sim":78.0, - "partner":"7dsb" - }, { "sim":78.0, "partner":"7df7" @@ -997332,15 +1002005,15 @@ }, { "sim":78.0, - "partner":"2he0" + "partner":"7dsb" }, { "sim":78.0, - "partner":"6m11" + "partner":"3aaa" }, { "sim":78.0, - "partner":"6m12" + "partner":"2he0" }, { "sim":78.0, @@ -997366,6 +1002039,14 @@ "sim":78.0, "partner":"4o1p" }, + { + "sim":78.0, + "partner":"6m11" + }, + { + "sim":78.0, + "partner":"6m12" + }, { "sim":78.0, "partner":"6aun" @@ -997444,11 +1002125,11 @@ }, { "sim":74.0, - "partner":"1k1a" + "partner":"1k1b" }, { "sim":74.0, - "partner":"1k1b" + "partner":"1k1a" }, { "sim":74.0, @@ -997474,10 +1002155,6 @@ "sim":73.0, "partner":"8sp8" }, - { - "sim":73.0, - "partner":"7k4a" - }, { "sim":73.0, "partner":"7k4b" @@ -997500,7 +1002177,7 @@ }, { "sim":73.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":73.0, @@ -997516,7 +1002193,7 @@ }, { "sim":73.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":73.0, @@ -997528,7 +1002205,7 @@ }, { "sim":73.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":73.0, @@ -997546,6 +1002223,10 @@ "sim":73.0, "partner":"6bo8" }, + { + "sim":73.0, + "partner":"6bo9" + }, { "sim":72.0, "partner":"1bi7" @@ -997588,15 +1002269,15 @@ }, { "sim":68.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":68.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":68.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":68.0, @@ -997752,19 +1002433,19 @@ }, { "sim":50.0, - "partner":"8u43" + "partner":"8u2z" }, { "sim":50.0, - "partner":"8u4d" + "partner":"8u43" }, { "sim":50.0, - "partner":"8u3a" + "partner":"8u4d" }, { "sim":50.0, - "partner":"8u2z" + "partner":"8u3a" }, { "sim":50.0, @@ -997778,18 +1002459,10 @@ "sim":50.0, "partner":"5is0" }, - { - "sim":50.0, - "partner":"7mzc" - }, { "sim":50.0, "partner":"7l2v" }, - { - "sim":50.0, - "partner":"8t3l" - }, { "sim":50.0, "partner":"7mzd" @@ -997800,7 +1002473,7 @@ }, { "sim":50.0, - "partner":"8t3m" + "partner":"8t3l" }, { "sim":50.0, @@ -997818,6 +1002491,10 @@ "sim":50.0, "partner":"7l2x" }, + { + "sim":50.0, + "partner":"8t3m" + }, { "sim":50.0, "partner":"7l2r" @@ -997852,35 +1002529,35 @@ }, { "sim":50.0, - "partner":"8t0y" + "partner":"7mzc" }, { "sim":50.0, - "partner":"8u3l" + "partner":"8t0y" }, { "sim":50.0, - "partner":"8t0c" + "partner":"8u30" }, { "sim":50.0, - "partner":"8u30" + "partner":"8u3c" }, { "sim":50.0, - "partner":"8t0e" + "partner":"8t0c" }, { "sim":50.0, - "partner":"8t10" + "partner":"8t0e" }, { "sim":50.0, - "partner":"8u3c" + "partner":"8t10" }, { "sim":50.0, - "partner":"7l2n" + "partner":"8u3l" }, { "sim":50.0, @@ -997916,32 +1002593,28 @@ }, { "sim":50.0, - "partner":"7lqy" + "partner":"7l2n" }, { "sim":50.0, - "partner":"7lqz" + "partner":"7lqy" }, { "sim":50.0, - "partner":"7lr0" + "partner":"7lqz" }, { "sim":50.0, - "partner":"7lpd" + "partner":"7lr0" }, { "sim":50.0, - "partner":"7rqu" + "partner":"7lpe" }, { "sim":50.0, "partner":"7rqv" }, - { - "sim":50.0, - "partner":"7lpe" - }, { "sim":50.0, "partner":"7rqw" @@ -997973,6 +1002646,14 @@ { "sim":50.0, "partner":"7lpc" + }, + { + "sim":50.0, + "partner":"7rqu" + }, + { + "sim":50.0, + "partner":"7lpd" } ], "struct_thr_sim_designed":[ @@ -997983,11 +1002664,11 @@ ], "seq_max_sim_designed":{ "sim":342.0, - "partner":"8qla" + "partner":"8ql3" }, "seq_max_sim_natural":{ "sim":342.0, - "partner":"7yz0" + "partner":"6mzf" }, "struct_max_sim_designed":[ @@ -998088,77 +1002769,77 @@ ], "subtitle":"Solution structure of a de novo designed 12-stranded transmembrane beta-barrel in ldao micelles", "tags":[ - "membrane protein", - "structure from cyana 3.98.15" + "structure from cyana 3.98.15", + "membrane protein" ], "keywords":[ - "general", + "geometries", + "stably", + "designing", + "engineering", + "models", + "limited", + "naturally", + "design", + "custom", + "transmembrane", + "number", + "show", "opens", + "current", "unlimited", - "considerable", - "designs", - "channels", - "magnetic", - "models", - "picosiemens", - "resembling", - "nanopores", - "approach", "de", - "novo", - "conductances", + "starting", + "structures", + "correlate", "ranging", - "contrast", - "principle", - "door", - "desired", - "stably", - "pore", - "properties", - "number", - "geometries", - "diameter", - "different", - "custom", "approaches", - "broad", - "provide", - "current", - "diameters", - "nuclear", - "engineering", - "occurring", - "sensors", + "different", "potential", - "limited", - "folded", + "pore", + "nanopore", "points", + "properties", + "provide", + "new", "110", - "show", - "design", - "sensing", - "crystallographic", - "characterization", - "structures", - "naturally", "protein", - "pores", - "nanometer", - "applications", - "nanopore", - "designing", - "describe", - "resonance", + "magnetic", + "folded", + "approach", + "conductances", + "characterization", + "broad", + "picosiemens", + "considerable", + "sensing", + "contrast", + "novo", + "general", + "diameter", + "430", "sequencing", + "resonance", + "nanopores", + "channels", "distinct", - "transmembrane", - "430", + "nanometer", + "resembling", + "sensors", + "principle", "suboptimal", - "starting", - "correlate", + "diameters", + "applications", + "nuclear", + "range", + "describe", "create", - "new", - "range" + "desired", + "crystallographic", + "designs", + "door", + "pores", + "occurring" ], "release_date":"2024-10-16", "publication":"\"Sculpting conducting nanopore size and shape through de novo protein design\", Science, 385, 282-288", @@ -998287,75 +1002968,75 @@ "subtitle":"Structure of ubiquitin bound of coiled-coil uim form 2", "tags":[ "ubiquitin", - "uim", "coiled-coil peptide", + "uim", "signaling protein" ], "keywords":[ - "coiled", - "polarization", - "original", - "studies", - "rise", - "exhibits", - "cc", - "low", - "report", - "stable", - "strategy", - "binder", - "hybrid", - "act", - "peptide", - "stronger", - "preorganization", - "number", - "challenging", - "interacting", - "small", - "residues", + "affinity", "crosslinked", - "short", - "assays", - "successful", - "binders", - "recognition", - "reconciles", - "motif", - "crystal", + "fluorescence", + "complex", + "designing", "often", - "uim", "events", - "furthermore", - "chemically", - "domains", - "scaffold", - "features", + "recognition", + "interacting", + "challenging", "design", - "show", "sequences", - "gives", - "onto", - "helical", - "interactions", "enhanced", - "present", - "complex", - "ub", - "designing", - "structure", - "sequence", - "conformationally", - "coil", + "compared", + "onto", "key", - "mediated", - "fluorescence", + "show", + "binders", "ubiquitin", - "affinity", + "number", + "polarization", + "furthermore", + "conformationally", + "residues", + "important", + "stronger", + "uim", + "structure", + "report", + "gives", + "assays", + "short", + "exhibits", + "successful", + "strategy", + "preorganization", + "interactions", + "chemically", "known", - "compared", + "helical", "binding", - "important" + "low", + "cc", + "motif", + "act", + "coiled", + "mediated", + "domains", + "binder", + "scaffold", + "ub", + "coil", + "small", + "sequence", + "original", + "studies", + "present", + "crystal", + "stable", + "hybrid", + "peptide", + "features", + "reconciles", + "rise" ], "release_date":"2024-09-18", "publication":"\"An engineered ubiquitin binding coiled coil peptide\", Chem Sci, 15, 15776-15782", @@ -998476,70 +1003157,70 @@ "signaling protein" ], "keywords":[ - "coiled", - "polarization", - "original", - "studies", - "rise", - "exhibits", - "cc", - "low", - "report", - "stable", - "strategy", - "binder", - "hybrid", - "act", - "peptide", - "stronger", - "preorganization", - "number", - "challenging", - "interacting", - "small", - "residues", + "affinity", "crosslinked", - "short", - "assays", - "successful", - "binders", - "recognition", - "reconciles", - "motif", - "crystal", + "fluorescence", + "complex", + "designing", "often", - "uim", "events", - "furthermore", - "chemically", - "domains", - "scaffold", - "features", + "recognition", + "interacting", + "challenging", "design", - "show", "sequences", - "gives", - "onto", - "helical", - "interactions", "enhanced", - "present", - "complex", - "ub", - "designing", - "structure", - "sequence", - "conformationally", - "coil", + "compared", + "onto", "key", - "mediated", - "fluorescence", + "show", + "binders", "ubiquitin", - "affinity", + "number", + "polarization", + "furthermore", + "conformationally", + "residues", + "important", + "stronger", + "uim", + "structure", + "report", + "gives", + "assays", + "short", + "exhibits", + "successful", + "strategy", + "preorganization", + "interactions", + "chemically", "known", - "compared", + "helical", "binding", - "important" + "low", + "cc", + "motif", + "act", + "coiled", + "mediated", + "domains", + "binder", + "scaffold", + "ub", + "coil", + "small", + "sequence", + "original", + "studies", + "present", + "crystal", + "stable", + "hybrid", + "peptide", + "features", + "reconciles", + "rise" ], "release_date":"2024-09-18", "publication":"\"An engineered ubiquitin binding coiled coil peptide\", Chem Sci, 15, 15776-15782", @@ -998660,6 +1003341,10 @@ "forename":"M.", "surname":"Pacesa" }, + { + "forename":"M.", + "surname":"Elia" + }, { "forename":"P.", "surname":"Gainza" @@ -998681,8 +1003366,8 @@ "surname":"Reymond" }, { - "forename":"M.", - "surname":"Elia" + "forename":"Y.", + "surname":"Miao" }, { "forename":"L.", @@ -998722,28 +1003407,116 @@ ], "subtitle":"Progesterone-bound db3 fab in complex with computationally designed dbpro1156_2 protein binder", "tags":[ - "binder", + "fab", + "de novo", + "de novo protein", "progesterone", "anti-kappa", - "de novo protein", - "de novo", - "fab" + "binder" ], "keywords":[ - "description", - "found" + "molecular", + "recognition", + "fingerprints", + "learning", + "structural", + "complexes", + "regulation", + "three", + "new", + "generalizability", + "strategy", + "therapies", + "drive", + "protein", + "representations", + "accurate", + "cells", + "systems", + "anticipate", + "trained", + "recent", + "induced", + "leveraged", + "10", + "deep", + "geometric", + "learned", + "conditioned", + "remarkably", + "engineered", + "however", + "mechanistic", + "assessed", + "experimentally", + "biological", + "surfaces", + "approach", + "proteins", + "develop", + "characterization", + "small", + "higher", + "pathways", + "computational", + "tools", + "1", + "emerged", + "task", + "surface", + "advances", + "design", + "challenging", + "living", + "binders", + "field", + "processes", + "potential", + "assembly", + "neosurfaces", + "chemically", + "validated", + "applied", + "demonstrated", + "repertoire", + "levels", + "expand", + "present", + "could", + "designed", + "events", + "specificities", + "mutational", + "providing", + "approaches", + "previously", + "based", + "synthetic", + "demonstration", + "powerful", + "arising", + "target", + "interactions", + "molecules", + "remained", + "innovative", + "sensing", + "high", + "uncommon", + "despite", + "affinities" ], "release_date":"2024-10-30", - "publication":"To be published", + "publication":"\"Targeting protein-ligand neosurfaces with a generalizable deep learning tool\", Nature", "publication_ref":{ - "DOI":"", - "PubMed":"", - "CSD":"", - "ISSN":"", - "ASTM":"" + "DOI":"10.1038\/s41586-024-08435-4", + "PubMed":"39814890", + "CSD":"0006", + "ISSN":"1476-4687", + "ASTM":"NATUAS" }, - "publication_country":"", - "abstract":"No description found.", + "publication_country":"UK", + "abstract":"Molecular recognition events between proteins drive biological processes in living systems 1 . However, higher levels of mechanistic regulation have emerged, in which protein-protein interactions are conditioned to small molecules 2-5 . Despite recent advances, computational tools for the design of new chemically induced protein interactions have remained a challenging task for the field 6,7 . Here we present a computational strategy for the design of proteins that target neosurfaces, that is, surfaces arising from protein-ligand complexes. To develop this strategy, we leveraged a geometric deep learning approach based on learned molecular surface representations 8,9 and experimentally validated binders against three drug-bound protein complexes: Bcl2-venetoclax, DB3-progesterone and PDF1-actinonin. All binders demonstrated high affinities and accurate specificities, as assessed by mutational and structural characterization. Remarkably, surface fingerprints previously trained only on proteins could be applied to neosurfaces induced by interactions with small molecules, providing a powerful demonstration of generalizability that is uncommon in other deep learning approaches. We anticipate that such designed chemically induced protein interactions will have the potential to expand the sensing repertoire and the assembly of new synthetic pathways in engineered cells for innovative drug-controlled cell-based therapies 10 .", "crystal_structure":{ "length_a":"1.00", "length_b":"1.00", @@ -998770,40660 +1003543,40852 @@ "partner":"6pyc" }, { - "sim":387.0, - "partner":"7u62" + "sim":417.0, + "partner":"5ezi" }, { - "sim":372.0, - "partner":"7u61" + "sim":416.0, + "partner":"7t0l" }, { - "sim":371.0, - "partner":"6z06" + "sim":413.0, + "partner":"8yxi" }, { - "sim":371.0, - "partner":"7b09" + "sim":413.0, + "partner":"5ezj" }, { - "sim":369.0, - "partner":"7l5j" + "sim":413.0, + "partner":"5ezl" }, { - "sim":369.0, - "partner":"4ncc" + "sim":413.0, + "partner":"5ezo" }, { - "sim":364.0, - "partner":"8gkj" + "sim":410.0, + "partner":"2q8a" }, { - "sim":364.0, - "partner":"8gkl" + "sim":410.0, + "partner":"2q8b" }, { - "sim":362.0, - "partner":"2ez0" + "sim":408.0, + "partner":"3vfg" }, { - 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"partner":"8bpg" + "partner":"8bpf" }, { "sim":50.0, - "partner":"8bpf" + "partner":"8bpg" }, { "sim":50.0, @@ -1039580,12 +1044545,36 @@ { "sim":50.0, "partner":"7qdo" + }, + { + "sim":74.0, + "partner":"8u0y" + }, + { + "sim":67.0, + "partner":"8vz9" + }, + { + "sim":59.0, + "partner":"8sku" + }, + { + "sim":59.0, + "partner":"8skv" + }, + { + "sim":51.0, + "partner":"2w59" } ], "struct_thr_sim_designed":[ ], "struct_thr_sim_natural":[ + { + "sim":0.9510999918, + "partner":"8fjb" + }, { "sim":0.951300025, "partner":"5ezl" @@ -1039609,10 +1044598,6 @@ { "sim":0.9502000213, "partner":"5nbw" - }, - { - "sim":0.9510999918, - "partner":"8fjb" } ], "seq_max_sim_designed":[ @@ -1039649,8 +1044634,48 @@ ], "authors":[ { - "forename":"L.", + "forename":"L.F.", "surname":"Di Costanzo" + }, + { + "forename":"G.", + "surname":"Sgueglia" + }, + { + "forename":"C.", + "surname":"Orlando" + }, + { + "forename":"M.", + "surname":"Polentarutti" + }, + { + "forename":"L.", + "surname":"Leone" + }, + { + "forename":"S.", + "surname":"La Gatta" + }, + { + "forename":"M.", + "surname":"De Fenza" + }, + { + "forename":"L.", + "surname":"De Gioia" + }, + { + "forename":"A.", + "surname":"Lombardi" + }, + { + "forename":"F.", + "surname":"Arrigoni" + }, + { + "forename":"M.", + "surname":"Chino" } ], "classification":"unknown", @@ -1039662,27 +1044687,123 @@ ], "subtitle":"Crystal structure of the artificial protein metp in complex with cadmium ion at different temperature (data set at 100 k)", "tags":[ - "room temperature", "cadmium-sulphur cluster", + "de novo design", "denovo protein", "de novo protein", - "de novo design" + "room temperature" ], "keywords":[ - "description", - "found" + "molecular", + "role", + "structural", + "insights", + "mirroring", + "rubredoxins", + "complexes", + "matrix", + "rapidly", + "folding", + "exhibits", + "protein", + "study", + "motions", + "electron", + "across", + "coordination", + "recoil", + "composed", + "two", + "applications", + "adapt", + "k", + "crystal", + "temperatures", + "involved", + "100", + "similar", + "correlating", + "complex", + "simulations", + "flexibility", + "dynamic", + "metal", + "metalloproteins", + "particularly", + "residues", + "comprehensive", + "lengths", + "packing", + "sulfur", + "ions", + "intramolecular", + "300", + "hydrogen", + "bond", + "elucidates", + "increase", + "bonding", + "metpsc1", + "redox", + "highlight", + "designing", + "design", + "subtle", + "suggests", + "natural", + "functional", + "anisotropic", + "shifts", + "potential", + "atoms", + "bonds", + "unveil", + "varying", + "allows", + "backbone", + "upon", + "notably", + "plasticity", + "concerted", + "unique", + "mechanism", + "catalysis", + "miniaturized", + "dynamics", + "advancing", + "bioremediation", + "reveal", + "radii", + "cadmium", + "cycling", + "cds", + "observed", + "contribute", + "report", + "findings", + "temperature", + "halves", + "crystallography", + "impact", + "spanning", + "artificial", + "investigation", + "sensing", + "conformations", + "stabilized", + "transfer" ], "release_date":"2024-12-04", - "publication":"To be published", + "publication":"\"Structural insights into temperature-dependent dynamics of METPsc1, a miniaturized electron-transfer protein\", J.Inorg.Biochem., 264, 112810-112810", "publication_ref":{ - "DOI":"", - "PubMed":"", - "CSD":"", - "ISSN":"", - "ASTM":"" + "DOI":"10.1016\/j.jinorgbio.2024.112810", + "PubMed":"39689412", + "CSD":"0525", + "ISSN":"0162-0134", + "ASTM":"JIBIDJ" }, - "publication_country":"", - "abstract":"No description found.", + "publication_country":"US", + "abstract":"The design of protein-metal complexes is rapidly advancing, with applications spanning catalysis, sensing, and bioremediation. We report a comprehensive investigation of METPsc1, a Miniaturized Electron Transfer Protein, in complex with cadmium. This study elucidates the impact of metal coordination on protein folding and structural dynamics across temperatures from 100\u00a0K to 300\u00a0K. Our findings reveal that METPsc1, composed of two similar halves stabilized by intramolecular hydrogen bonds, exhibits a unique \"clothespin-like\" recoil mechanism. This allows it to adapt to metal ions of varying radii, mirroring the flexibility observed in natural rubredoxins. High-resolution crystallography and molecular dynamics simulations unveil concerted backbone motions and subtle temperature-dependent shifts in side-chain conformations, particularly for residues involved in crystal packing. Notably, CdS bond lengths increase with temperature, correlating with anisotropic motions of the sulfur atoms involved in second-shell hydrogen bonding. This suggests a dynamic role of protein matrix upon redox cycling. These insights into METPsc1 highlight its potential for catalysis and contribute to the designing of artificial metalloproteins with functional plasticity.", "crystal_structure":{ "length_a":"37.070", "length_b":"56.654", @@ -1039703,31 +1044824,31 @@ "seq_thr_sim_designed":[ { "sim":65.0, - "partner":"5sbj" + "partner":"9g3c" }, { "sim":65.0, - "partner":"9g3b" + "partner":"5sbg" }, { "sim":65.0, - "partner":"5sbi" + "partner":"9g3a" }, { "sim":65.0, - "partner":"9g3c" + "partner":"5sbj" }, { "sim":65.0, - "partner":"9g3u" + "partner":"9g3b" }, { "sim":65.0, - "partner":"9g3a" + "partner":"9g3u" }, { "sim":65.0, - "partner":"5sbg" + "partner":"5sbi" } ], "seq_thr_sim_natural":[ @@ -1039768,7 +1044889,7 @@ ], "seq_max_sim_designed":{ "sim":65.0, - "partner":"5sbj" + "partner":"9g3c" }, "seq_max_sim_natural":[ @@ -1039800,131 +1044921,263 @@ ], "authors":[ { - "forename":"L.", + "forename":"L.F.", "surname":"Di Costanzo" }, { - "forename":"M.", - "surname":"Chino" - } - ], - "classification":"unknown", - "classification_suggested":[ - - ], - "classification_suggested_reason":[ - - ], - "subtitle":"Crystal structure of the artificial protein metp in complex with cadmium ion at different temperature, 160 k", - "tags":[ - "room temperature", - "cadmium-sulphur cluster", - "denovo protein", - "de novo protein", - "de novo design" - ], - "keywords":[ - "description", - "found" - ], - "release_date":"2024-12-04", - "publication":"To be published", - "publication_ref":{ - "DOI":"", - "PubMed":"", - "CSD":"", - "ISSN":"", - "ASTM":"" - }, - "publication_country":"", - "abstract":"No description found.", - "crystal_structure":{ - "length_a":"37.384", - "length_b":"56.338", - "length_c":"19.191", - "angle_a":"90.000", - "angle_b":"90.000", - "angle_g":"90.000" - }, - "symmetry":"C 2 2 21", - "exptl_method":[ - "X-RAY DIFFRACTION" - ], - "formula_weight":2955.254, - "synthesis_comment":"Chemically synthesized", - "review":true, - "previous_design":"9g39", - "next_design":"9g3b", - "seq_thr_sim_designed":[ - { - "sim":65.0, - "partner":"5sbj" - }, - { - "sim":65.0, - "partner":"9g3b" - }, - { - "sim":65.0, - "partner":"5sbi" - }, - { - "sim":65.0, - "partner":"9g3c" + "forename":"G.", + "surname":"Sgueglia" }, { - "sim":65.0, - "partner":"9g39" + "forename":"C.", + "surname":"Orlando" }, { - "sim":65.0, - "partner":"9g3u" + "forename":"M.", + "surname":"Polentarutti" }, { - "sim":65.0, - "partner":"5sbg" - } - ], - "seq_thr_sim_natural":[ - - ], - "struct_thr_sim_designed":[ - { - "sim":1.0, - "partner":"9g3b" + "forename":"L.", + "surname":"Leone" }, { - "sim":1.0, - "partner":"9g3u" + "forename":"S.", + "surname":"La Gatta" }, { - "sim":1.0, - "partner":"5sbg" + "forename":"M.", + "surname":"De Fenza" }, { - "sim":1.0, - "partner":"5sbj" + "forename":"L.", + "surname":"De Gioia" }, { - "sim":1.0, - "partner":"9g39" + "forename":"A.", + "surname":"Lombardi" }, { - "sim":1.0, - "partner":"5sbi" + "forename":"F.", + "surname":"Arrigoni" }, { - "sim":1.0, - "partner":"9g3c" + "forename":"M.", + "surname":"Chino" } ], - "struct_thr_sim_natural":[ + "classification":"unknown", + "classification_suggested":[ ], - "seq_max_sim_designed":{ - "sim":65.0, - "partner":"5sbj" - }, + "classification_suggested_reason":[ + + ], + "subtitle":"Crystal structure of the artificial protein metp in complex with cadmium ion at different temperature, 160 k", + "tags":[ + "cadmium-sulphur cluster", + "de novo design", + "denovo protein", + "de novo protein", + "room temperature" + ], + "keywords":[ + "molecular", + "role", + "structural", + "insights", + "mirroring", + "rubredoxins", + "complexes", + "matrix", + "rapidly", + "folding", + "exhibits", + "protein", + "study", + "motions", + "electron", + "across", + "coordination", + "recoil", + "composed", + "two", + "applications", + "adapt", + "k", + "crystal", + "temperatures", + "involved", + "100", + "similar", + "correlating", + "complex", + "simulations", + "flexibility", + "dynamic", + "metal", + "metalloproteins", + "particularly", + "residues", + "comprehensive", + "lengths", + "packing", + "sulfur", + "ions", + "intramolecular", + "300", + "hydrogen", + "bond", + "elucidates", + "increase", + "bonding", + "metpsc1", + "redox", + "highlight", + "designing", + "design", + "subtle", + "suggests", + "natural", + "functional", + "anisotropic", + "shifts", + "potential", + "atoms", + "bonds", + "unveil", + "varying", + "allows", + "backbone", + "upon", + "notably", + "plasticity", + "concerted", + "unique", + "mechanism", + "catalysis", + "miniaturized", + "dynamics", + "advancing", + "bioremediation", + "reveal", + "radii", + "cadmium", + "cycling", + "cds", + "observed", + "contribute", + "report", + "findings", + "temperature", + "halves", + "crystallography", + "impact", + "spanning", + "artificial", + "investigation", + "sensing", + "conformations", + "stabilized", + "transfer" + ], + "release_date":"2024-12-04", + "publication":"\"Structural insights into temperature-dependent dynamics of METPsc1, a miniaturized electron-transfer protein\", J.Inorg.Biochem., 264, 112810-112810", + "publication_ref":{ + "DOI":"10.1016\/j.jinorgbio.2024.112810", + "PubMed":"39689412", + "CSD":"0525", + "ISSN":"0162-0134", + "ASTM":"JIBIDJ" + }, + "publication_country":"US", + "abstract":"The design of protein-metal complexes is rapidly advancing, with applications spanning catalysis, sensing, and bioremediation. We report a comprehensive investigation of METPsc1, a Miniaturized Electron Transfer Protein, in complex with cadmium. This study elucidates the impact of metal coordination on protein folding and structural dynamics across temperatures from 100\u00a0K to 300\u00a0K. Our findings reveal that METPsc1, composed of two similar halves stabilized by intramolecular hydrogen bonds, exhibits a unique \"clothespin-like\" recoil mechanism. This allows it to adapt to metal ions of varying radii, mirroring the flexibility observed in natural rubredoxins. High-resolution crystallography and molecular dynamics simulations unveil concerted backbone motions and subtle temperature-dependent shifts in side-chain conformations, particularly for residues involved in crystal packing. Notably, CdS bond lengths increase with temperature, correlating with anisotropic motions of the sulfur atoms involved in second-shell hydrogen bonding. This suggests a dynamic role of protein matrix upon redox cycling. These insights into METPsc1 highlight its potential for catalysis and contribute to the designing of artificial metalloproteins with functional plasticity.", + "crystal_structure":{ + "length_a":"37.384", + "length_b":"56.338", + "length_c":"19.191", + "angle_a":"90.000", + "angle_b":"90.000", + "angle_g":"90.000" + }, + "symmetry":"C 2 2 21", + "exptl_method":[ + "X-RAY DIFFRACTION" + ], + "formula_weight":2955.254, + "synthesis_comment":"Chemically synthesized", + "review":true, + "previous_design":"9g39", + "next_design":"9g3b", + "seq_thr_sim_designed":[ + { + "sim":65.0, + "partner":"9g3c" + }, + { + "sim":65.0, + "partner":"5sbg" + }, + { + "sim":65.0, + "partner":"9g39" + }, + { + "sim":65.0, + "partner":"5sbj" + }, + { + "sim":65.0, + "partner":"9g3b" + }, + { + "sim":65.0, + "partner":"9g3u" + }, + { + "sim":65.0, + "partner":"5sbi" + } + ], + "seq_thr_sim_natural":[ + + ], + "struct_thr_sim_designed":[ + { + "sim":1.0, + "partner":"9g3b" + }, + { + "sim":1.0, + "partner":"9g3u" + }, + { + "sim":1.0, + "partner":"5sbg" + }, + { + "sim":1.0, + "partner":"5sbj" + }, + { + "sim":1.0, + "partner":"9g39" + }, + { + "sim":1.0, + "partner":"5sbi" + }, + { + "sim":1.0, + "partner":"9g3c" + } + ], + "struct_thr_sim_natural":[ + + ], + "seq_max_sim_designed":{ + "sim":65.0, + "partner":"9g3c" + }, "seq_max_sim_natural":[ ], @@ -1039955,9 +1045208,45 @@ ], "authors":[ { - "forename":"L.", + "forename":"L.F.", "surname":"Di Costanzo" }, + { + "forename":"G.", + "surname":"Sgueglia" + }, + { + "forename":"C.", + "surname":"Orlando" + }, + { + "forename":"M.", + "surname":"Polentarutti" + }, + { + "forename":"L.", + "surname":"Leone" + }, + { + "forename":"S.", + "surname":"La Gatta" + }, + { + "forename":"M.", + "surname":"De Fenza" + }, + { + "forename":"L.", + "surname":"De Gioia" + }, + { + "forename":"A.", + "surname":"Lombardi" + }, + { + "forename":"F.", + "surname":"Arrigoni" + }, { "forename":"M.", "surname":"Chino" @@ -1039972,27 +1045261,123 @@ ], "subtitle":"Crystal structure of the artificial protein metp in complex with cadmium ion at different temperature, 130 k", "tags":[ - "room temperature", "cadmium-sulphur cluster", + "de novo design", "denovo protein", "de novo protein", - "de novo design" + "room temperature" ], "keywords":[ - "description", - "found" + "molecular", + "role", + "structural", + "insights", + "mirroring", + "rubredoxins", + "complexes", + "matrix", + "rapidly", + "folding", + "exhibits", + "protein", + "study", + "motions", + "electron", + "across", + "coordination", + "recoil", + "composed", + "two", + "applications", + "adapt", + "k", + "crystal", + "temperatures", + "involved", + "100", + "similar", + "correlating", + "complex", + "simulations", + "flexibility", + "dynamic", + "metal", + "metalloproteins", + "particularly", + "residues", + "comprehensive", + "lengths", + "packing", + "sulfur", + "ions", + "intramolecular", + "300", + "hydrogen", + "bond", + "elucidates", + "increase", + "bonding", + "metpsc1", + "redox", + "highlight", + "designing", + "design", + "subtle", + "suggests", + "natural", + "functional", + "anisotropic", + "shifts", + "potential", + "atoms", + "bonds", + "unveil", + "varying", + "allows", + "backbone", + "upon", + "notably", + "plasticity", + "concerted", + "unique", + "mechanism", + "catalysis", + "miniaturized", + "dynamics", + "advancing", + "bioremediation", + "reveal", + "radii", + "cadmium", + "cycling", + "cds", + "observed", + "contribute", + "report", + "findings", + "temperature", + "halves", + "crystallography", + "impact", + "spanning", + "artificial", + "investigation", + "sensing", + "conformations", + "stabilized", + "transfer" ], "release_date":"2024-12-04", - "publication":"To be published", + "publication":"\"Structural insights into temperature-dependent dynamics of METPsc1, a miniaturized electron-transfer protein\", J.Inorg.Biochem., 264, 112810-112810", "publication_ref":{ - "DOI":"", - "PubMed":"", - "CSD":"", - "ISSN":"", - "ASTM":"" + "DOI":"10.1016\/j.jinorgbio.2024.112810", + "PubMed":"39689412", + "CSD":"0525", + "ISSN":"0162-0134", + "ASTM":"JIBIDJ" }, - "publication_country":"", - "abstract":"No description found.", + "publication_country":"US", + "abstract":"The design of protein-metal complexes is rapidly advancing, with applications spanning catalysis, sensing, and bioremediation. We report a comprehensive investigation of METPsc1, a Miniaturized Electron Transfer Protein, in complex with cadmium. This study elucidates the impact of metal coordination on protein folding and structural dynamics across temperatures from 100\u00a0K to 300\u00a0K. Our findings reveal that METPsc1, composed of two similar halves stabilized by intramolecular hydrogen bonds, exhibits a unique \"clothespin-like\" recoil mechanism. This allows it to adapt to metal ions of varying radii, mirroring the flexibility observed in natural rubredoxins. High-resolution crystallography and molecular dynamics simulations unveil concerted backbone motions and subtle temperature-dependent shifts in side-chain conformations, particularly for residues involved in crystal packing. Notably, CdS bond lengths increase with temperature, correlating with anisotropic motions of the sulfur atoms involved in second-shell hydrogen bonding. This suggests a dynamic role of protein matrix upon redox cycling. These insights into METPsc1 highlight its potential for catalysis and contribute to the designing of artificial metalloproteins with functional plasticity.", "crystal_structure":{ "length_a":"34.419", "length_b":"56.352", @@ -1040013,15 +1045398,15 @@ "seq_thr_sim_designed":[ { "sim":65.0, - "partner":"5sbj" + "partner":"9g3c" }, { "sim":65.0, - "partner":"5sbi" + "partner":"5sbg" }, { "sim":65.0, - "partner":"9g3c" + "partner":"9g3a" }, { "sim":65.0, @@ -1040029,15 +1045414,15 @@ }, { "sim":65.0, - "partner":"9g3u" + "partner":"5sbj" }, { "sim":65.0, - "partner":"9g3a" + "partner":"9g3u" }, { "sim":65.0, - "partner":"5sbg" + "partner":"5sbi" } ], "seq_thr_sim_natural":[ @@ -1040078,7 +1045463,7 @@ ], "seq_max_sim_designed":{ "sim":65.0, - "partner":"5sbj" + "partner":"9g3c" }, "seq_max_sim_natural":[ @@ -1040110,9 +1045495,45 @@ ], "authors":[ { - "forename":"L.", + "forename":"L.F.", "surname":"Di Costanzo" }, + { + "forename":"G.", + "surname":"Sgueglia" + }, + { + "forename":"C.", + "surname":"Orlando" + }, + { + "forename":"M.", + "surname":"Polentarutti" + }, + { + "forename":"L.", + "surname":"Leone" + }, + { + "forename":"S.", + "surname":"La Gatta" + }, + { + "forename":"M.", + "surname":"De Fenza" + }, + { + "forename":"L.", + "surname":"De Gioia" + }, + { + "forename":"A.", + "surname":"Lombardi" + }, + { + "forename":"F.", + "surname":"Arrigoni" + }, { "forename":"M.", "surname":"Chino" @@ -1040127,27 +1045548,123 @@ ], "subtitle":"Crystal structure of the artificial protein metp in complex with cadmium ion at different temperatures. 200 k data collection", "tags":[ - "room temperature", "cadmium-sulphur cluster", + "de novo design", "denovo protein", "de novo protein", - "de novo design" + "room temperature" ], "keywords":[ - "description", - "found" + "molecular", + "role", + "structural", + "insights", + "mirroring", + "rubredoxins", + "complexes", + "matrix", + "rapidly", + "folding", + "exhibits", + "protein", + "study", + "motions", + "electron", + "across", + "coordination", + "recoil", + "composed", + "two", + "applications", + "adapt", + "k", + "crystal", + "temperatures", + "involved", + "100", + "similar", + "correlating", + "complex", + "simulations", + "flexibility", + "dynamic", + "metal", + "metalloproteins", + "particularly", + "residues", + "comprehensive", + "lengths", + "packing", + "sulfur", + "ions", + "intramolecular", + "300", + "hydrogen", + "bond", + "elucidates", + "increase", + "bonding", + "metpsc1", + "redox", + "highlight", + "designing", + "design", + "subtle", + "suggests", + "natural", + "functional", + "anisotropic", + "shifts", + "potential", + "atoms", + "bonds", + "unveil", + "varying", + "allows", + "backbone", + "upon", + "notably", + "plasticity", + "concerted", + "unique", + "mechanism", + "catalysis", + "miniaturized", + "dynamics", + "advancing", + "bioremediation", + "reveal", + "radii", + "cadmium", + "cycling", + "cds", + "observed", + "contribute", + "report", + "findings", + "temperature", + "halves", + "crystallography", + "impact", + "spanning", + "artificial", + "investigation", + "sensing", + "conformations", + "stabilized", + "transfer" ], "release_date":"2024-12-04", - "publication":"To be published", + "publication":"\"Structural insights into temperature-dependent dynamics of METPsc1, a miniaturized electron-transfer protein\", J.Inorg.Biochem., 264, 112810-112810", "publication_ref":{ - "DOI":"", - "PubMed":"", - "CSD":"", - "ISSN":"", - "ASTM":"" + "DOI":"10.1016\/j.jinorgbio.2024.112810", + "PubMed":"39689412", + "CSD":"0525", + "ISSN":"0162-0134", + "ASTM":"JIBIDJ" }, - "publication_country":"", - "abstract":"No description found.", + "publication_country":"US", + "abstract":"The design of protein-metal complexes is rapidly advancing, with applications spanning catalysis, sensing, and bioremediation. We report a comprehensive investigation of METPsc1, a Miniaturized Electron Transfer Protein, in complex with cadmium. This study elucidates the impact of metal coordination on protein folding and structural dynamics across temperatures from 100\u00a0K to 300\u00a0K. Our findings reveal that METPsc1, composed of two similar halves stabilized by intramolecular hydrogen bonds, exhibits a unique \"clothespin-like\" recoil mechanism. This allows it to adapt to metal ions of varying radii, mirroring the flexibility observed in natural rubredoxins. High-resolution crystallography and molecular dynamics simulations unveil concerted backbone motions and subtle temperature-dependent shifts in side-chain conformations, particularly for residues involved in crystal packing. Notably, CdS bond lengths increase with temperature, correlating with anisotropic motions of the sulfur atoms involved in second-shell hydrogen bonding. This suggests a dynamic role of protein matrix upon redox cycling. These insights into METPsc1 highlight its potential for catalysis and contribute to the designing of artificial metalloproteins with functional plasticity.", "crystal_structure":{ "length_a":"37.830", "length_b":"56.655", @@ -1040168,31 +1045685,31 @@ "seq_thr_sim_designed":[ { "sim":65.0, - "partner":"5sbj" + "partner":"5sbg" }, { "sim":65.0, - "partner":"9g3b" + "partner":"9g3a" }, { "sim":65.0, - "partner":"5sbi" + "partner":"9g39" }, { "sim":65.0, - "partner":"9g39" + "partner":"5sbj" }, { "sim":65.0, - "partner":"9g3u" + "partner":"9g3b" }, { "sim":65.0, - "partner":"9g3a" + "partner":"9g3u" }, { "sim":65.0, - "partner":"5sbg" + "partner":"5sbi" } ], "seq_thr_sim_natural":[ @@ -1040233,7 +1045750,7 @@ ], "seq_max_sim_designed":{ "sim":65.0, - "partner":"5sbj" + "partner":"5sbg" }, "seq_max_sim_natural":[ @@ -1040265,9 +1045782,45 @@ ], "authors":[ { - "forename":"L.", + "forename":"L.F.", "surname":"Di Costanzo" }, + { + "forename":"G.", + "surname":"Sgueglia" + }, + { + "forename":"C.", + "surname":"Orlando" + }, + { + "forename":"M.", + "surname":"Polentarutti" + }, + { + "forename":"L.", + "surname":"Leone" + }, + { + "forename":"S.", + "surname":"La Gatta" + }, + { + "forename":"M.", + "surname":"De Fenza" + }, + { + "forename":"L.", + "surname":"De Gioia" + }, + { + "forename":"A.", + "surname":"Lombardi" + }, + { + "forename":"F.", + "surname":"Arrigoni" + }, { "forename":"M.", "surname":"Chino" @@ -1040282,27 +1045835,123 @@ ], "subtitle":"Crystal structure of the artificial protein metp in complex with cadmium ion at different temperatures. room temperature data collection", "tags":[ - "room temperature", "cadmium-sulphur cluster", + "de novo design", "denovo protein", "de novo protein", - "de novo design" + "room temperature" ], "keywords":[ - "description", - "found" + "molecular", + "role", + "structural", + "insights", + "mirroring", + "rubredoxins", + "complexes", + "matrix", + "rapidly", + "folding", + "exhibits", + "protein", + "study", + "motions", + "electron", + "across", + "coordination", + "recoil", + "composed", + "two", + "applications", + "adapt", + "k", + "crystal", + "temperatures", + "involved", + "100", + "similar", + "correlating", + "complex", + "simulations", + "flexibility", + "dynamic", + "metal", + "metalloproteins", + "particularly", + "residues", + "comprehensive", + "lengths", + "packing", + "sulfur", + "ions", + "intramolecular", + "300", + "hydrogen", + "bond", + "elucidates", + "increase", + "bonding", + "metpsc1", + "redox", + "highlight", + "designing", + "design", + "subtle", + "suggests", + "natural", + "functional", + "anisotropic", + "shifts", + "potential", + "atoms", + "bonds", + "unveil", + "varying", + "allows", + "backbone", + "upon", + "notably", + "plasticity", + "concerted", + "unique", + "mechanism", + "catalysis", + "miniaturized", + "dynamics", + "advancing", + "bioremediation", + "reveal", + "radii", + "cadmium", + "cycling", + "cds", + "observed", + "contribute", + "report", + "findings", + "temperature", + "halves", + "crystallography", + "impact", + "spanning", + "artificial", + "investigation", + "sensing", + "conformations", + "stabilized", + "transfer" ], "release_date":"2024-12-04", - "publication":"To be published", + "publication":"\"Structural insights into temperature-dependent dynamics of METPsc1, a miniaturized electron-transfer protein\", J.Inorg.Biochem., 264, 112810-112810", "publication_ref":{ - "DOI":"", - "PubMed":"", - "CSD":"", - "ISSN":"", - "ASTM":"" + "DOI":"10.1016\/j.jinorgbio.2024.112810", + "PubMed":"39689412", + "CSD":"0525", + "ISSN":"0162-0134", + "ASTM":"JIBIDJ" }, - "publication_country":"", - "abstract":"No description found.", + "publication_country":"US", + "abstract":"The design of protein-metal complexes is rapidly advancing, with applications spanning catalysis, sensing, and bioremediation. We report a comprehensive investigation of METPsc1, a Miniaturized Electron Transfer Protein, in complex with cadmium. This study elucidates the impact of metal coordination on protein folding and structural dynamics across temperatures from 100\u00a0K to 300\u00a0K. Our findings reveal that METPsc1, composed of two similar halves stabilized by intramolecular hydrogen bonds, exhibits a unique \"clothespin-like\" recoil mechanism. This allows it to adapt to metal ions of varying radii, mirroring the flexibility observed in natural rubredoxins. High-resolution crystallography and molecular dynamics simulations unveil concerted backbone motions and subtle temperature-dependent shifts in side-chain conformations, particularly for residues involved in crystal packing. Notably, CdS bond lengths increase with temperature, correlating with anisotropic motions of the sulfur atoms involved in second-shell hydrogen bonding. This suggests a dynamic role of protein matrix upon redox cycling. These insights into METPsc1 highlight its potential for catalysis and contribute to the designing of artificial metalloproteins with functional plasticity.", "crystal_structure":{ "length_a":"35.029", "length_b":"57.107", @@ -1040319,35 +1045968,35 @@ "synthesis_comment":"Chemically synthesized", "review":true, "previous_design":"9g3c", - "next_design":"9gnb", + "next_design":"9gf2", "seq_thr_sim_designed":[ { "sim":65.0, - "partner":"5sbj" + "partner":"9g3c" }, { "sim":65.0, - "partner":"9g3b" + "partner":"5sbg" }, { "sim":65.0, - "partner":"5sbi" + "partner":"9g3a" }, { "sim":65.0, - "partner":"9g3c" + "partner":"9g39" }, { "sim":65.0, - "partner":"9g39" + "partner":"5sbj" }, { "sim":65.0, - "partner":"9g3a" + "partner":"9g3b" }, { "sim":65.0, - "partner":"5sbg" + "partner":"5sbi" } ], "seq_thr_sim_natural":[ @@ -1040388,7 +1046037,7 @@ ], "seq_max_sim_designed":{ "sim":65.0, - "partner":"5sbj" + "partner":"9g3c" }, "seq_max_sim_natural":[ @@ -1040406,30 +1046055,870 @@ ] }, { - "pdb":"9gnb", - "picture_path":"https:\/\/cdn.rcsb.org\/images\/structures\/9gnb_assembly-1.jpeg", + "pdb":"9gf2", + "picture_path":"https:\/\/cdn.rcsb.org\/images\/structures\/9gf2_assembly-1.jpeg", "chains":[ { - "chain_id":"A", + "chain_id":"A,B,C,D,E,F", + "chain_source":"unknown", + "chain_type":"U", + "chain_seq_unnat":"(ACE)GEIAKSLKEIAKSAAAALKEIAWSLKEIAKSLKG(NH2)", + "chain_seq_nat":"XGEIAKSLKEIAKSAAAALKEIAWSLKEIAKSLKGX", + "chain_length":36 + } + ], + "authors":[ + { + "forename":"K.W.", + "surname":"Kurgan" + }, + { + "forename":"F.J.O.", + "surname":"Martin" + }, + { + "forename":"W.M.", + "surname":"Dawson" + }, + { + "forename":"T.", + "surname":"Brunnock" + }, + { + "forename":"A.J.", + "surname":"Orr-Ewing" + }, + { + "forename":"D.N.", + "surname":"Woolfson" + } + ], + "classification":"unknown", + "classification_suggested":[ + "rational" + ], + "classification_suggested_reason":[ + "Author is: D.N. Woolfson" + ], + "subtitle":"Cc-hex-hen2 variant peptide with hendecad repeat substitution", + "tags":[ + "de novo protein", + "hendecad repeat", + "de novo design", + "coiled-coils" + ], + "keywords":[ + "repeats", + "dimers", + "finally", + "interestingly", + "single", + "positioning", + "within", + "promiscuous", + "new", + "bridge", + "\u03bcm", + "orthogonality", + "protein", + "study", + "200", + "reporter", + "salt", + "across", + "rapid", + "novo", + "straightforward", + "polypeptides", + "implement", + "systems", + "two", + "using", + "faithful", + "similar", + "improve", + "reconcile", + "dynamic", + "however", + "delivering", + "thus", + "homotypic", + "finding", + "examining", + "useful", + "modules", + "develop", + "generally", + "concentration", + "former", + "chemical", + "coils", + "peptide", + "set", + "undergo", + "aspect", + "design", + "pace", + "biology", + "different", + "species", + "oligomeric", + "properties", + "application", + "apply", + "explore", + "namely", + "incorporating", + "series", + "broadly", + "states", + "exchange", + "peptides", + "heptamers", + "implications", + "whereas", + "deliver", + "assemblies", + "dynamics", + "designed", + "form", + "assay", + "sequences", + "many", + "one", + "others", + "strategies", + "promiscuity", + "structures", + "de", + "first", + "oligomers", + "detailed", + "synthetic", + "alternate", + "provide", + "findings", + "minutes", + "interactions", + "known", + "would", + "find", + "coiled", + "strand", + "heterotypic", + "coil", + "unexpected", + "assessing", + "designs", + "less", + "dimeric", + "ii" + ], + "release_date":"2025-01-22", + "publication":"\"Exchange, promiscuity, and orthogonality in de novo designed coiled-coil peptide assemblies\", Chem Sci", + "publication_ref":{ + "DOI":"10.1039\/d4sc06329e", + "PubMed":"39720134", + "CSD":"", + "ISSN":"2041-6520", + "ASTM":"" + }, + "publication_country":"UK", + "abstract":" De novo protein design is delivering new peptide and protein structures at a rapid pace. Many of these synthetic polypeptides form well-defined and hyperthermal-stable structures. Generally, however, less is known about the dynamic properties of the de novo designed structures. Here, we explore one aspect of dynamics in a series of de novo coiled-coil peptide assemblies: namely, peptide exchange within and between different oligomers from dimers through to heptamers. First, we develop a fluorescence-based reporter assay for peptide exchange that is straightforward to implement, and, thus, would be useful to others examining similar systems. We apply this assay to explore both homotypic exchange within single species, and heterotypic exchange between coiled coils of different oligomeric states. For the former, we provide a detailed study for a dimeric coiled coil, CC-Di, finding a half-life for exchange of 4.2 \u00b1 0.3 minutes at a peptide concentration of 200 \u03bcM. Interestingly, more broadly when assessing exchange across all of the oligomeric states, we find that some of the designs are faithful and only undergo homotypic strand exchange, whereas others are promiscuous and exchange to form unexpected hetero-oligomers. Finally, we develop two design strategies to improve the orthogonality of the different oligomers: (i) using alternate positioning of salt bridge interactions; and (ii) incorporating non-canonical repeats into the designed sequences. In so doing, we reconcile the promiscuity and deliver a set of faithful homo-oligomeric de novo coiled-coil peptides. Our findings have implications for the application of these and other coiled coils as modules in chemical and synthetic biology.", + "crystal_structure":{ + "length_a":"48.563", + "length_b":"58.157", + "length_c":"59.258", + "angle_a":"90", + "angle_b":"90", + "angle_g":"90" + }, + "symmetry":"P 2 21 21", + "exptl_method":[ + "X-RAY DIFFRACTION" + ], + "formula_weight":3585.284, + "synthesis_comment":"", + "review":true, + "previous_design":"9g3u", + "next_design":"9gf3", + "seq_thr_sim_designed":[ + { + "sim":54.0, + "partner":"9gf3" + }, + { + "sim":52.0, + "partner":"4pn9" + }, + { + "sim":52.0, + "partner":"6eiz" + } + ], + "seq_thr_sim_natural":[ + + ], + "struct_thr_sim_designed":[ + { + "sim":0.9865999818, + "partner":"9gf3" + }, + { + "sim":0.9800999761, + "partner":"9gf4" + }, + { + "sim":0.9624000192, + "partner":"6xy1" + }, + { + "sim":0.9502000213, + "partner":"7bau" + }, + { + "sim":0.9624000192, + "partner":"8b16" + }, + { + "sim":0.9581999779, + "partner":"6xy0" + }, + { + "sim":0.9610000253, + "partner":"7bim" + }, + { + "sim":0.9610000253, + "partner":"7nfi" + }, + { + "sim":0.9610000253, + "partner":"4pna" + }, + { + "sim":0.9584000111, + "partner":"6g6a" + }, + { + "sim":0.9624000192, + "partner":"7bas" + }, + { + "sim":0.9624000192, + "partner":"7bav" + }, + { + "sim":0.9635999799, + "partner":"6g6c" + }, + { + "sim":0.9610000253, + "partner":"6g6d" + }, + { + "sim":0.9596999884, + "partner":"7nfg" + }, + { + "sim":0.9624000192, + "partner":"7nfj" + }, + { + "sim":0.9624000192, + "partner":"6g6g" + }, + { + "sim":0.9610000253, + "partner":"7a1t" + }, + { + "sim":0.9624000192, + "partner":"7baw" + }, + { + "sim":0.9613000154, + "partner":"5ez8" + }, + { + "sim":0.9636999965, + "partner":"6yb2" + }, + { + "sim":0.9607999921, + "partner":"7bat" + }, + { + "sim":0.9624000192, + "partner":"7nfl" + }, + { + "sim":0.9606999755, + "partner":"7nfm" + }, + { + "sim":0.9570999742, + "partner":"6g6b" + }, + { + "sim":0.9592999816, + "partner":"6g69" + }, + { + "sim":0.9624000192, + "partner":"6zt1" + }, + { + "sim":0.9624000192, + "partner":"7nff" + }, + { + "sim":0.9512000084, + "partner":"6g67" + }, + { + "sim":0.9580000043, + "partner":"6g68" + }, + { + "sim":0.9552999735, + "partner":"7bo9" + }, + { + "sim":0.9580000043, + "partner":"6g66" + }, + { + "sim":0.9564999938, + "partner":"4pnd" + }, + { + "sim":0.969900012, + "partner":"6yaz" + }, + { + "sim":0.9570000172, + "partner":"7bo8" + } + ], + "struct_thr_sim_natural":[ + + ], + "seq_max_sim_designed":{ + "sim":54.0, + "partner":"9gf3" + }, + "seq_max_sim_natural":[ + + ], + "struct_max_sim_designed":{ + "sim":0.9865999818, + "partner":"9gf3" + }, + "struct_max_sim_natural":[ + + ], + "review_comment":[ + "" + ] + }, + { + "pdb":"9gf3", + "picture_path":"https:\/\/cdn.rcsb.org\/images\/structures\/9gf3_assembly-1.jpeg", + "chains":[ + { + "chain_id":"M,N,C,D,E,F,G,H,I,J,K,L,A,B", + "chain_source":"unknown", + "chain_type":"U", + "chain_seq_unnat":"(ACE)GEIAQALKEIAKAAAAALKEIAWALKEIAQALKG(NH2)", + "chain_seq_nat":"XGEIAQALKEIAKAAAAALKEIAWALKEIAQALKGX", + "chain_length":36 + } + ], + "authors":[ + { + "forename":"K.W.", + "surname":"Kurgan" + }, + { + "forename":"F.J.O.", + "surname":"Martin" + }, + { + "forename":"W.M.", + "surname":"Dawson" + }, + { + "forename":"T.", + "surname":"Brunnock" + }, + { + "forename":"A.J.", + "surname":"Orr-Ewing" + }, + { + "forename":"D.N.", + "surname":"Woolfson" + } + ], + "classification":"unknown", + "classification_suggested":[ + "rational" + ], + "classification_suggested_reason":[ + "Author is: D.N. Woolfson" + ], + "subtitle":"Cc-hept-hen2 variant peptide with hendecad repeat substitution", + "tags":[ + "de novo protein", + "hendecad repeat", + "de novo design", + "coiled-coil" + ], + "keywords":[ + "repeats", + "dimers", + "finally", + "interestingly", + "single", + "positioning", + "within", + "promiscuous", + "new", + "bridge", + "\u03bcm", + "orthogonality", + "protein", + "study", + "200", + "reporter", + "salt", + "across", + "rapid", + "novo", + "straightforward", + "polypeptides", + "implement", + "systems", + "two", + "using", + "faithful", + "similar", + "improve", + "reconcile", + "dynamic", + "however", + "delivering", + "thus", + "homotypic", + "finding", + "examining", + "useful", + "modules", + "develop", + "generally", + "concentration", + "former", + "chemical", + "coils", + "peptide", + "set", + "undergo", + "aspect", + "design", + "pace", + "biology", + "different", + "species", + "oligomeric", + "properties", + "application", + "apply", + "explore", + "namely", + "incorporating", + "series", + "broadly", + "states", + "exchange", + "peptides", + "heptamers", + "implications", + "whereas", + "deliver", + "assemblies", + "dynamics", + "designed", + "form", + "assay", + "sequences", + "many", + "one", + "others", + "strategies", + "promiscuity", + "structures", + "de", + "first", + "oligomers", + "detailed", + "synthetic", + "alternate", + "provide", + "findings", + "minutes", + "interactions", + "known", + "would", + "find", + "coiled", + "strand", + "heterotypic", + "coil", + "unexpected", + "assessing", + "designs", + "less", + "dimeric", + "ii" + ], + "release_date":"2025-01-22", + "publication":"\"Exchange, promiscuity, and orthogonality in de novo designed coiled-coil peptide assemblies\", Chem Sci", + "publication_ref":{ + "DOI":"10.1039\/d4sc06329e", + "PubMed":"39720134", + "CSD":"", + "ISSN":"2041-6520", + "ASTM":"" + }, + "publication_country":"UK", + "abstract":" De novo protein design is delivering new peptide and protein structures at a rapid pace. Many of these synthetic polypeptides form well-defined and hyperthermal-stable structures. Generally, however, less is known about the dynamic properties of the de novo designed structures. Here, we explore one aspect of dynamics in a series of de novo coiled-coil peptide assemblies: namely, peptide exchange within and between different oligomers from dimers through to heptamers. First, we develop a fluorescence-based reporter assay for peptide exchange that is straightforward to implement, and, thus, would be useful to others examining similar systems. We apply this assay to explore both homotypic exchange within single species, and heterotypic exchange between coiled coils of different oligomeric states. For the former, we provide a detailed study for a dimeric coiled coil, CC-Di, finding a half-life for exchange of 4.2 \u00b1 0.3 minutes at a peptide concentration of 200 \u03bcM. Interestingly, more broadly when assessing exchange across all of the oligomeric states, we find that some of the designs are faithful and only undergo homotypic strand exchange, whereas others are promiscuous and exchange to form unexpected hetero-oligomers. Finally, we develop two design strategies to improve the orthogonality of the different oligomers: (i) using alternate positioning of salt bridge interactions; and (ii) incorporating non-canonical repeats into the designed sequences. In so doing, we reconcile the promiscuity and deliver a set of faithful homo-oligomeric de novo coiled-coil peptides. Our findings have implications for the application of these and other coiled coils as modules in chemical and synthetic biology.", + "crystal_structure":{ + "length_a":"60.267", + "length_b":"61.754", + "length_c":"154.441", + "angle_a":"90.00", + "angle_b":"90.00", + "angle_g":"90.00" + }, + "symmetry":"P 21 21 21", + "exptl_method":[ + "X-RAY DIFFRACTION" + ], + "formula_weight":3519.183, + "synthesis_comment":"", + "review":true, + "previous_design":"9gf2", + "next_design":"9gf4", + "seq_thr_sim_designed":[ + { + "sim":55.0, + "partner":"9gf4" + }, + { + "sim":53.0, + "partner":"9gf2" + }, + { + "sim":51.0, + "partner":"4pna" + }, + { + "sim":51.0, + "partner":"7nfg" + }, + { + "sim":50.0, + "partner":"7nfi" + }, + { + "sim":50.0, + "partner":"7nfj" + } + ], + "seq_thr_sim_natural":[ + + ], + "struct_thr_sim_designed":[ + { + "sim":0.9872000217, + "partner":"9gf2" + }, + { + "sim":1.0, + "partner":"9gf4" + } + ], + "struct_thr_sim_natural":[ + + ], + "seq_max_sim_designed":{ + "sim":55.0, + "partner":"9gf4" + }, + "seq_max_sim_natural":[ + + ], + "struct_max_sim_designed":{ + "sim":1.0, + "partner":"9gf4" + }, + "struct_max_sim_natural":[ + + ], + "review_comment":[ + "" + ] + }, + { + "pdb":"9gf4", + "picture_path":"https:\/\/cdn.rcsb.org\/images\/structures\/9gf4_assembly-1.jpeg", + "chains":[ + { + "chain_id":"A,B,C,D,E,F,G", + "chain_source":"unknown", + "chain_type":"U", + "chain_seq_unnat":"(ACE)GEVAQAIKEVAKAVAAAIKEVAWAIKEVAQAIKG(NH2)", + "chain_seq_nat":"XGEVAQAIKEVAKAVAAAIKEVAWAIKEVAQAIKGX", + "chain_length":36 + } + ], + "authors":[ + { + "forename":"K.W.", + "surname":"Kurgan" + }, + { + "forename":"F.J.O.", + "surname":"Martin" + }, + { + "forename":"W.M.", + "surname":"Dawson" + }, + { + "forename":"T.", + "surname":"Brunnock" + }, + { + "forename":"A.J.", + "surname":"Orr-Ewing" + }, + { + "forename":"D.N.", + "surname":"Woolfson" + } + ], + "classification":"unknown", + "classification_suggested":[ + "rational" + ], + "classification_suggested_reason":[ + "Author is: D.N. Woolfson" + ], + "subtitle":"Cc-hept-iv-hen2 variant peptide with hendecad repeat substitution", + "tags":[ + "de novo protein", + "hendecad repeat", + "de novo design", + "coiled-coil" + ], + "keywords":[ + "repeats", + "dimers", + "finally", + "interestingly", + "single", + "positioning", + "within", + "promiscuous", + "new", + "bridge", + "\u03bcm", + "orthogonality", + "protein", + "study", + "200", + "reporter", + "salt", + "across", + "rapid", + "novo", + "straightforward", + "polypeptides", + "implement", + "systems", + "two", + "using", + "faithful", + "similar", + "improve", + "reconcile", + "dynamic", + "however", + "delivering", + "thus", + "homotypic", + "finding", + "examining", + "useful", + "modules", + "develop", + "generally", + "concentration", + "former", + "chemical", + "coils", + "peptide", + "set", + "undergo", + "aspect", + "design", + "pace", + "biology", + "different", + "species", + "oligomeric", + "properties", + "application", + "apply", + "explore", + "namely", + "incorporating", + "series", + "broadly", + "states", + "exchange", + "peptides", + "heptamers", + "implications", + "whereas", + "deliver", + "assemblies", + "dynamics", + "designed", + "form", + "assay", + "sequences", + "many", + "one", + "others", + "strategies", + "promiscuity", + "structures", + "de", + "first", + "oligomers", + "detailed", + "synthetic", + "alternate", + "provide", + "findings", + "minutes", + "interactions", + "known", + "would", + "find", + "coiled", + "strand", + "heterotypic", + "coil", + "unexpected", + "assessing", + "designs", + "less", + "dimeric", + "ii" + ], + "release_date":"2025-01-22", + "publication":"\"Exchange, promiscuity, and orthogonality in de novo designed coiled-coil peptide assemblies\", Chem Sci", + "publication_ref":{ + "DOI":"10.1039\/d4sc06329e", + "PubMed":"39720134", + "CSD":"", + "ISSN":"2041-6520", + "ASTM":"" + }, + "publication_country":"UK", + "abstract":" De novo protein design is delivering new peptide and protein structures at a rapid pace. Many of these synthetic polypeptides form well-defined and hyperthermal-stable structures. Generally, however, less is known about the dynamic properties of the de novo designed structures. Here, we explore one aspect of dynamics in a series of de novo coiled-coil peptide assemblies: namely, peptide exchange within and between different oligomers from dimers through to heptamers. First, we develop a fluorescence-based reporter assay for peptide exchange that is straightforward to implement, and, thus, would be useful to others examining similar systems. We apply this assay to explore both homotypic exchange within single species, and heterotypic exchange between coiled coils of different oligomeric states. For the former, we provide a detailed study for a dimeric coiled coil, CC-Di, finding a half-life for exchange of 4.2 \u00b1 0.3 minutes at a peptide concentration of 200 \u03bcM. Interestingly, more broadly when assessing exchange across all of the oligomeric states, we find that some of the designs are faithful and only undergo homotypic strand exchange, whereas others are promiscuous and exchange to form unexpected hetero-oligomers. Finally, we develop two design strategies to improve the orthogonality of the different oligomers: (i) using alternate positioning of salt bridge interactions; and (ii) incorporating non-canonical repeats into the designed sequences. In so doing, we reconcile the promiscuity and deliver a set of faithful homo-oligomeric de novo coiled-coil peptides. Our findings have implications for the application of these and other coiled coils as modules in chemical and synthetic biology.", + "crystal_structure":{ + "length_a":"38.546", + "length_b":"47.919", + "length_c":"153.020", + "angle_a":"90.00", + "angle_b":"90.00", + "angle_g":"90.00" + }, + "symmetry":"P 2 21 21", + "exptl_method":[ + "X-RAY DIFFRACTION" + ], + "formula_weight":3491.127, + "synthesis_comment":"", + "review":true, + "previous_design":"9gf3", + "next_design":"9glq", + "seq_thr_sim_designed":[ + + ], + "seq_thr_sim_natural":[ + + ], + "struct_thr_sim_designed":[ + { + "sim":1.0, + "partner":"9gf3" + }, + { + "sim":0.980799973, + "partner":"9gf2" + } + ], + "struct_thr_sim_natural":[ + + ], + "seq_max_sim_designed":[ + + ], + "seq_max_sim_natural":[ + + ], + "struct_max_sim_designed":{ + "sim":1.0, + "partner":"9gf3" + }, + "struct_max_sim_natural":[ + + ], + "review_comment":[ + "" + ] + }, + { + "pdb":"9glq", + "picture_path":"https:\/\/cdn.rcsb.org\/images\/structures\/9glq_assembly-1.jpeg", + "chains":[ + { + "chain_id":"A,B", "chain_source":"Homo sapiens", "chain_type":"N", - "chain_seq_unnat":"GSADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQ", - "chain_seq_nat":"GSADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQ", - "chain_length":64 + "chain_seq_unnat":"GSDEDTYYLQVRGRKNFEILMKLKESLELMELVPQPLVDSYRQQQQLLQR", + "chain_seq_nat":"GSDEDTYYLQVRGRKNFEILMKLKESLELMELVPQPLVDSYRQQQQLLQR", + "chain_length":50 }, { - "chain_id":"B", + "chain_id":"C", "chain_source":"unknown", "chain_type":"U", - "chain_seq_unnat":"GSDLGKKLLEAARAGQDDEVRILMANGADVNALDSWGFTPLHLAAFFGHLEIVEVLLKTGADVNAVDNAGTTPLHLAAHAGHLEIVEVLLKAGADVNAHDQHGTVTPLHLAAHMGHLEIVEVLLKHGADVNAQDKFGKTPFDLAIDNGNEDIAEVLQKAA", - "chain_seq_nat":"GSDLGKKLLEAARAGQDDEVRILMANGADVNALDSWGFTPLHLAAFFGHLEIVEVLLKTGADVNAVDNAGTTPLHLAAHAGHLEIVEVLLKAGADVNAHDQHGTVTPLHLAAHMGHLEIVEVLLKHGADVNAQDKFGKTPFDLAIDNGNEDIAEVLQKAA", - "chain_length":161 + "chain_seq_unnat":"GSDLGKKLLEAAAVGQDDEVRILMANGADVNAMDQNGETPLHLAAMNGHLEIVEVLLKTGADVNASDFHGDTPLHLAAMAGHLEIVEVLLKHGADVNAQDTWGYIPFDLAAWAGNEDIAEVLQKAA", + "chain_seq_nat":"GSDLGKKLLEAAAVGQDDEVRILMANGADVNAMDQNGETPLHLAAMNGHLEIVEVLLKTGADVNASDFHGDTPLHLAAMAGHLEIVEVLLKHGADVNAQDTWGYIPFDLAAWAGNEDIAEVLQKAA", + "chain_length":127 } ], "authors":[ { "forename":"P.", - "surname":"Muenick" + "surname":"Munick" }, { "forename":"J.", @@ -1040438,288 +1046927,3450 @@ { "forename":"A.", "surname":"Strubel" + }, + { + "forename":"N.", + "surname":"Gutfreund" + }, + { + "forename":"B.", + "surname":"Dreier" + }, + { + "forename":"J.V.", + "surname":"Schaefer" + }, + { + "forename":"B.", + "surname":"Schafer" + }, + { + "forename":"J.", + "surname":"Gebel" + }, + { + "forename":"C.", + "surname":"Osterburg" + }, + { + "forename":"A.", + "surname":"Chaikuad" + }, + { + "forename":"S.", + "surname":"Knapp" + }, + { + "forename":"A.", + "surname":"Pluckthun" + }, + { + "forename":"V.", + "surname":"Dotsch" } ], "classification":"unknown", "classification_suggested":[ - + "consensus" ], "classification_suggested_reason":[ - + "Author is: A. Pluckthun" ], - "subtitle":"Structure of p73 sam domain in complex with darpin b9", + "subtitle":"Crystal structure of p73 tetramerisation domain in complex with darpins 1800", "tags":[ - "tumor suppressor", - "transcription", + "sgc", "tp73", - "cancer", - "transcription factor", - "darpin" + "structural genomics consortium", + "tetramerisation domain", + "darpins", + "structural genomics", + "dna binding protein" ], "keywords":[ - "description", - "found" + "requirement", + "isoform", + "molecular", + "development", + "repeat", + "amenable", + "complexes", + "well", + "simultaneously", + "lead", + "protein", + "pockets", + "tissue", + "binding", + "cellular", + "close", + "demonstrate", + "transcription", + "adaptor", + "two", + "attractive", + "binds", + "bioptotacs", + "either", + "alternative", + "p53", + "interest", + "proteolysis", + "family", + "targets", + "fused", + "makes", + "spop", + "bind", + "approach", + "proteins", + "modules", + "member", + "characterization", + "speckle", + "factor", + "ankyrin", + "highly", + "small", + "pulldown", + "chemical", + "eliminates", + "introduced", + "required", + "lysates", + "molecule", + "effective", + "need", + "pocket", + "p73", + "protac", + "\u03b4np73\u03b1", + "used", + "sam", + "represent", + "proximity", + "virtually", + "domain", + "targeting", + "selective", + "pharmacologically", + "experiments", + "beyond", + "also", + "cell", + "oligomerization", + "reactivates", + "type", + "degradation", + "primary", + "poz", + "inhibition", + "range", + "describe", + "method", + "darpins", + "culture", + "directly", + "designed", + "bioprotacs", + "ligase", + "one", + "targeted", + "classical", + "occupancy", + "extension", + "e3", + "synthesized", + "yields", + "based", + "staining", + "concept", + "module", + "linkage", + "target", + "inhibitors", + "bring", + "class", + "molecules", + "chimeras", + "tpd", + "degraders", + "generated", + "extend", + "glue", + "fusing" ], - "release_date":"2024-12-18", - "publication":"To be published", + "release_date":"2025-01-22", + "publication":"\"DARPins as a novel tool to detect and degrade p73\", Cell Death Dis, 15, 909-909", "publication_ref":{ - "DOI":"", - "PubMed":"", + "DOI":"10.1038\/s41419-024-07304-2", + "PubMed":"39695090", "CSD":"", - "ISSN":"", + "ISSN":"2041-4889", "ASTM":"" }, "publication_country":"", - "abstract":"No description found.", + "abstract":"The concept of Targeted Protein Degradation (TPD) has been introduced as an attractive alternative to the development of classical inhibitors. TPD can extend the range of proteins that can be pharmacologically targeted beyond the classical targets for small molecule inhibitors, as a binding pocket is required but its occupancy does not need to lead to inhibition. The method is based on either small molecules that simultaneously bind to a protein of interest and to a cellular E3 ligase and bring them in close proximity (molecular glue) or a bi-functional molecule synthesized from the chemical linkage of a target protein-specific small molecule and one that binds to an E3 ligase (Proteolysis Targeting Chimeras (PROTAC)). The further extension of this approach to bioPROTACs, in which a small protein-based binding module is fused directly to an E3 ligase or an E3 ligase adaptor protein, makes virtually all proteins amenable to targeted degradation, as this method eliminates the requirement for binding pockets for small molecules. Designed Ankyrin Repeat Proteins (DARPins) represent a very attractive class of small protein-based binding modules that can be used for the development of bioPTOTACS. Here we describe the characterization of two DARPins generated against the oligomerization domain and the SAM domain of the transcription factor p73, a member of the p53 protein family. The DARPins can be used for (isoform-)selective pulldown experiments both in cell culture as well as primary tissue lysates. We also demonstrate that they can be used for staining in cell culture experiments. Fusing them to the speckle type POZ protein (SPOP), an adaptor protein for cullin-3 E3 ligase complexes, yields highly selective and effective degraders. We demonstrate that selective degradation of the \u0394Np73\u03b1 isoform reactivates p53.", "crystal_structure":{ - "length_a":"48.304", - "length_b":"31.234", - "length_c":"68.355", - "angle_a":"90.000", - "angle_b":"95.970", - "angle_g":"90.000" + "length_a":"62.763", + "length_b":"94.816", + "length_c":"96.433", + "angle_a":"90.00", + "angle_b":"90.00", + "angle_g":"90.00" }, - "symmetry":"P 1 21 1", + "symmetry":"I 2 2 2", "exptl_method":[ "X-RAY DIFFRACTION" ], - "formula_weight":7178.164, + "formula_weight":6034.894, "synthesis_comment":"", "review":true, - "previous_design":"9g3u", - "next_design":"9hac", + "previous_design":"9gf4", + "next_design":"9gnb", "seq_thr_sim_designed":[ { - "sim":277.0, - "partner":"6fp9" + "sim":217.0, + "partner":"8ak1" }, { - "sim":273.0, - "partner":"7b4w" + "sim":211.0, + "partner":"8aiw" }, { - "sim":271.0, - "partner":"7z7c" + "sim":200.0, + "partner":"7z73" }, { - "sim":269.0, - "partner":"7b4t" + "sim":199.0, + "partner":"8hkh" }, { - "sim":268.0, + "sim":198.0, + "partner":"8rci" + }, + { + "sim":198.0, + "partner":"7b4u" + }, + { + "sim":198.0, + "partner":"7b4v" + }, + { + "sim":193.0, "partner":"7z7e" }, { - "sim":267.0, - "partner":"8u1b" + "sim":192.0, + "partner":"9f07" }, { - "sim":266.0, - "partner":"7zyu" + "sim":190.0, + "partner":"9f23" }, { - "sim":266.0, - "partner":"6fpb" + "sim":190.0, + "partner":"8u1b" }, { - "sim":266.0, - "partner":"6fpa" + "sim":189.0, + "partner":"7z7c" }, { - "sim":265.0, - "partner":"7z72" + "sim":189.0, + "partner":"7b4t" }, { - "sim":264.0, + "sim":188.0, "partner":"7z71" }, { - "sim":262.0, - "partner":"8aed" + "sim":188.0, + "partner":"8ql3" }, { - "sim":261.0, - "partner":"2xee" + "sim":188.0, + "partner":"9f8g" }, { - "sim":261.0, - "partner":"5oou" + "sim":188.0, + "partner":"8ql6" }, { - "sim":261.0, - "partner":"8a19" + "sim":188.0, + "partner":"8qla" }, { - "sim":259.0, - "partner":"5oos" + "sim":188.0, + "partner":"8ql8" }, { - "sim":259.0, - "partner":"8qla" + "sim":188.0, + "partner":"4dui" }, { - "sim":259.0, + "sim":188.0, "partner":"8qea" }, { - "sim":259.0, - "partner":"4dui" + "sim":188.0, + "partner":"8qlb" }, { - "sim":259.0, + "sim":188.0, "partner":"8ql9" }, { - "sim":259.0, - "partner":"8ql8" + "sim":188.0, + "partner":"8ql7" }, { - "sim":259.0, - "partner":"8ql3" + "sim":188.0, + "partner":"8ql4" }, { - "sim":259.0, - "partner":"9f8g" + "sim":188.0, + "partner":"8ql2" }, { - "sim":259.0, - "partner":"8ql6" + "sim":188.0, + "partner":"8ql5" }, { - "sim":259.0, - "partner":"8ql5" + "sim":187.0, + "partner":"9f22" }, { - "sim":259.0, - "partner":"8ql4" + "sim":186.0, + "partner":"9f24" }, { - "sim":259.0, - "partner":"8ql7" + "sim":186.0, + "partner":"2jab" }, { - "sim":259.0, - "partner":"8qlb" + "sim":186.0, + "partner":"7zyu" }, { - "sim":259.0, - "partner":"8ql2" + "sim":186.0, + "partner":"6fpb" }, { - "sim":256.0, + "sim":186.0, + "partner":"6fpa" + }, + { + "sim":185.0, "partner":"2bkg" }, { - "sim":256.0, + "sim":185.0, + "partner":"5oos" + }, + { + "sim":185.0, + "partner":"6fp9" + }, + { + "sim":185.0, + "partner":"8a1a" + }, + { + "sim":184.0, + "partner":"7z72" + }, + { + "sim":184.0, + "partner":"9gnb" + }, + { + "sim":184.0, + "partner":"7b4w" + }, + { + "sim":184.0, + "partner":"5oou" + }, + { + "sim":184.0, "partner":"5kng" }, { - "sim":256.0, + "sim":184.0, + "partner":"5knh" + }, + { + "sim":184.0, "partner":"7dnf" }, { - "sim":256.0, - "partner":"5knh" + "sim":184.0, + "partner":"4j7w" }, { - "sim":256.0, + "sim":184.0, "partner":"7dng" }, { - "sim":255.0, - "partner":"5op3" + "sim":184.0, + "partner":"4j8y" }, { - "sim":255.0, - "partner":"8a1a" + "sim":182.0, + "partner":"8a19" }, { - "sim":254.0, - "partner":"4ydw" + "sim":181.0, + "partner":"5op3" }, { - "sim":254.0, - "partner":"4j8y" + "sim":181.0, + "partner":"4ydw" }, { - "sim":254.0, - "partner":"4j7w" + "sim":178.0, + "partner":"2xee" }, { - "sim":253.0, + "sim":178.0, "partner":"2xeh" }, { - "sim":249.0, - "partner":"4atz" + "sim":178.0, + "partner":"8aed" }, { - "sim":248.0, - "partner":"9f22" + "sim":177.0, + "partner":"5le9" }, { - "sim":247.0, - "partner":"6c9k" + "sim":177.0, + "partner":"5lea" }, { - "sim":246.0, - "partner":"5lw2" + "sim":175.0, + "partner":"6fes" }, { - "sim":246.0, - "partner":"8ve7" + "sim":173.0, + "partner":"4atz" }, { - "sim":242.0, - "partner":"5leb" + "sim":173.0, + "partner":"5lw2" }, { - "sim":241.0, - "partner":"7dne" + "sim":173.0, + "partner":"5le3" }, { - "sim":240.0, - "partner":"5le9" + "sim":173.0, + "partner":"5le6" }, { - "sim":240.0, - "partner":"5lea" + "sim":173.0, + "partner":"5le4" }, { - "sim":240.0, + "sim":173.0, "partner":"5le7" }, { - "sim":239.0, + "sim":173.0, "partner":"5le8" }, { - "sim":239.0, + "sim":173.0, + "partner":"5leb" + }, + { + "sim":173.0, + "partner":"5lee" + }, + { + "sim":173.0, + "partner":"5led" + }, + { + "sim":173.0, + "partner":"5lec" + }, + { + "sim":173.0, "partner":"5le2" }, { - "sim":237.0, - "partner":"5le3" + "sim":172.0, + 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+ "Author is: A. Pluckthun" + ], + "subtitle":"Structure of p73 sam domain in complex with darpin b9", + "tags":[ + "tp73", + "darpin", + "transcription factor", + "cancer", + "transcription", + "tumor suppressor" + ], + "keywords":[ + "requirement", + "isoform", + "molecular", + "development", + "repeat", + "amenable", + "complexes", + "well", + "simultaneously", + "lead", + "protein", + "pockets", + "tissue", + "binding", + "cellular", + "close", + "demonstrate", + "transcription", + "adaptor", + "two", + "attractive", + "binds", + "bioptotacs", + "either", + "alternative", + "p53", + "interest", + "proteolysis", + "family", + "targets", + "fused", + "makes", + "spop", + "bind", + "approach", + "proteins", + "modules", + "member", + "characterization", + "speckle", + "factor", + "ankyrin", + "highly", + "small", + "pulldown", + "chemical", + "eliminates", + "introduced", + "required", + "lysates", + "molecule", + "effective", + "need", + "pocket", + "p73", + "protac", + "\u03b4np73\u03b1", + "used", + "sam", + "represent", + "proximity", + "virtually", + "domain", + "targeting", + "selective", + "pharmacologically", + "experiments", + "beyond", + "also", + "cell", + "oligomerization", + "reactivates", + "type", + "degradation", + "primary", + "poz", + "inhibition", + "range", + "describe", + "method", + "darpins", + "culture", + "directly", + "designed", + "bioprotacs", + "ligase", + "one", + "targeted", + "classical", + "occupancy", + "extension", + "e3", + "synthesized", + "yields", + "based", + "staining", + "concept", + "module", + "linkage", + "target", + "inhibitors", + "bring", + "class", + "molecules", + "chimeras", + "tpd", + "degraders", + "generated", + "extend", + "glue", + "fusing" + ], + "release_date":"2024-12-18", + "publication":"\"DARPins as a novel tool to detect and degrade p73\", Cell Death Dis, 15, 909-909", + "publication_ref":{ + "DOI":"10.1038\/s41419-024-07304-2", + "PubMed":"39695090", + "CSD":"", + "ISSN":"2041-4889", + "ASTM":"" + }, + "publication_country":"", + "abstract":"The concept of Targeted Protein Degradation (TPD) has been introduced as an attractive alternative to the development of classical inhibitors. TPD can extend the range of proteins that can be pharmacologically targeted beyond the classical targets for small molecule inhibitors, as a binding pocket is required but its occupancy does not need to lead to inhibition. The method is based on either small molecules that simultaneously bind to a protein of interest and to a cellular E3 ligase and bring them in close proximity (molecular glue) or a bi-functional molecule synthesized from the chemical linkage of a target protein-specific small molecule and one that binds to an E3 ligase (Proteolysis Targeting Chimeras (PROTAC)). The further extension of this approach to bioPROTACs, in which a small protein-based binding module is fused directly to an E3 ligase or an E3 ligase adaptor protein, makes virtually all proteins amenable to targeted degradation, as this method eliminates the requirement for binding pockets for small molecules. Designed Ankyrin Repeat Proteins (DARPins) represent a very attractive class of small protein-based binding modules that can be used for the development of bioPTOTACS. Here we describe the characterization of two DARPins generated against the oligomerization domain and the SAM domain of the transcription factor p73, a member of the p53 protein family. The DARPins can be used for (isoform-)selective pulldown experiments both in cell culture as well as primary tissue lysates. We also demonstrate that they can be used for staining in cell culture experiments. Fusing them to the speckle type POZ protein (SPOP), an adaptor protein for cullin-3 E3 ligase complexes, yields highly selective and effective degraders. We demonstrate that selective degradation of the \u0394Np73\u03b1 isoform reactivates p53.", + "crystal_structure":{ + "length_a":"48.304", + "length_b":"31.234", + "length_c":"68.355", + "angle_a":"90.000", + "angle_b":"95.970", + "angle_g":"90.000" + }, + "symmetry":"P 1 21 1", + "exptl_method":[ + "X-RAY DIFFRACTION" + ], + "formula_weight":7178.164, + "synthesis_comment":"", + "review":true, + "previous_design":"9glq", + "next_design":"9hac", + "seq_thr_sim_designed":[ + { + "sim":277.0, + "partner":"6fp9" + }, + { + "sim":273.0, + "partner":"7b4w" + }, + { + "sim":271.0, + "partner":"7z7c" + }, + { + "sim":269.0, + "partner":"7b4t" + }, + { + "sim":268.0, + "partner":"7z7e" + }, + { + "sim":267.0, + "partner":"8u1b" + }, + { + "sim":266.0, + "partner":"7zyu" + }, + { + "sim":266.0, + "partner":"6fpb" + }, + { + "sim":266.0, + "partner":"6fpa" + }, + { + "sim":265.0, + "partner":"7z72" + }, + { + "sim":264.0, + "partner":"7z71" + }, + { + "sim":262.0, + "partner":"8aed" + }, + { + "sim":261.0, + "partner":"2xee" + }, + { + "sim":261.0, + "partner":"5oou" + }, + { + "sim":261.0, + "partner":"8a19" + }, + { + "sim":259.0, + "partner":"5oos" + }, + { + "sim":259.0, + "partner":"8ql3" + }, + { + "sim":259.0, + "partner":"9f8g" + }, + { + "sim":259.0, + "partner":"8ql6" + }, + { + "sim":259.0, + "partner":"8qla" + }, + { + "sim":259.0, + "partner":"8ql8" + }, + { + "sim":259.0, + "partner":"4dui" + }, + { + "sim":259.0, + "partner":"8qea" + }, + { + "sim":259.0, + "partner":"8qlb" + }, + { + "sim":259.0, + "partner":"8ql9" + }, + { + "sim":259.0, + "partner":"8ql7" + }, + { + "sim":259.0, + "partner":"8ql4" + }, + { + "sim":259.0, + "partner":"8ql2" + }, + { + "sim":259.0, + "partner":"8ql5" + }, + { + "sim":256.0, + "partner":"2bkg" + }, + { + "sim":256.0, + "partner":"5kng" + }, + { + "sim":256.0, + "partner":"5knh" + }, + { + "sim":256.0, + "partner":"7dnf" + }, + { + "sim":256.0, + "partner":"7dng" + }, + { + "sim":255.0, + "partner":"5op3" + }, + { + "sim":255.0, + "partner":"8a1a" + }, + { + "sim":254.0, + "partner":"4ydw" + }, + { + "sim":254.0, + "partner":"4j7w" + }, + { + "sim":254.0, + "partner":"4j8y" + }, + { + "sim":253.0, + "partner":"2xeh" + }, + { + "sim":249.0, + "partner":"4atz" + }, + { + "sim":248.0, + "partner":"9f22" + }, + { + "sim":247.0, + "partner":"6c9k" + }, + { + "sim":246.0, + "partner":"5lw2" + }, + { + "sim":246.0, + "partner":"8ve7" + }, + { + "sim":242.0, + "partner":"5leb" + }, + { + "sim":241.0, + "partner":"7dne" + }, + { + "sim":240.0, + "partner":"5le9" + }, + { + "sim":240.0, + "partner":"5lea" + }, + { + "sim":240.0, + "partner":"5le7" + }, + { + "sim":239.0, + "partner":"5le8" + }, + { + "sim":239.0, + "partner":"5le2" + }, + { + "sim":237.0, + "partner":"5le3" + }, + { + "sim":236.0, + "partner":"5le6" + }, + { + "sim":235.0, + "partner":"9f07" + }, + { + "sim":235.0, + "partner":"5lee" + }, + { + "sim":235.0, + "partner":"5led" + }, + { + "sim":235.0, + "partner":"5lec" }, { "sim":233.0, @@ -1040759,11 +1050410,11 @@ }, { "sim":224.0, - "partner":"7tbq" + "partner":"7tbn" }, { "sim":224.0, - "partner":"7tbn" + "partner":"7tbq" }, { "sim":224.0, @@ -1040775,11 +1050426,11 @@ }, { "sim":205.0, - "partner":"7b4v" + "partner":"7b4u" }, { "sim":205.0, - "partner":"7b4u" + "partner":"7b4v" }, { "sim":202.0, @@ -1040817,6 +1050468,10 @@ "sim":184.0, "partner":"9f24" }, + { + "sim":184.0, + "partner":"9glq" + }, { "sim":182.0, "partner":"4hqd" @@ -1040875,10 +1050530,6 @@ "sim":268.0, "partner":"6s9s" }, - { - "sim":267.0, - "partner":"8tzb" - }, { "sim":267.0, "partner":"8tzc" @@ -1040895,6 +1050546,10 @@ "sim":267.0, "partner":"8tzh" }, + { + "sim":267.0, + "partner":"8tzb" + }, { "sim":265.0, "partner":"3nog" @@ -1040917,11 +1050572,11 @@ }, { "sim":263.0, - "partner":"5oyj" + "partner":"4k5a" }, { "sim":263.0, - "partner":"4k5a" + "partner":"5oyj" }, { "sim":263.0, @@ -1040935,45 +1050590,25 @@ "sim":262.0, "partner":"5ma8" }, - { - "sim":262.0, - "partner":"5eno" - }, - { - "sim":262.0, - "partner":"6zob" - }, - { - "sim":262.0, - "partner":"6zo5" - }, { "sim":262.0, "partner":"4dx6" }, { "sim":262.0, - "partner":"6q4n" + "partner":"6sgs" }, { "sim":262.0, "partner":"6zoc" }, - { - "sim":262.0, - "partner":"5enp" - }, - { - "sim":262.0, - "partner":"6sgs" - }, { "sim":262.0, "partner":"6zo6" }, { "sim":262.0, - "partner":"4dx7" + "partner":"5enp" }, { "sim":262.0, @@ -1040981,7 +1050616,7 @@ }, { "sim":262.0, - "partner":"4u95" + "partner":"7b8r" }, { "sim":262.0, @@ -1040989,11 +1050624,11 @@ }, { "sim":262.0, - "partner":"7b8r" + "partner":"4dx7" }, { "sim":262.0, - "partner":"5enq" + "partner":"4u95" }, { "sim":262.0, @@ -1041003,6 +1050638,10 @@ "sim":262.0, "partner":"6zoe" }, + { + "sim":262.0, + "partner":"5enq" + }, { "sim":262.0, "partner":"6q4p" @@ -1041011,6 +1050650,10 @@ "sim":262.0, "partner":"6sgt" }, + { + "sim":262.0, + "partner":"7b8s" + }, { "sim":262.0, "partner":"7ouk" @@ -1041025,19 +1050668,19 @@ }, { "sim":262.0, - "partner":"7b8s" + "partner":"6zo8" }, { "sim":262.0, - "partner":"3noc" + "partner":"6zof" }, { "sim":262.0, - "partner":"6zo8" + "partner":"3noc" }, { "sim":262.0, - "partner":"6zof" + "partner":"6sgu" }, { "sim":262.0, @@ -1041045,31 +1050688,31 @@ }, { "sim":262.0, - "partner":"4u8v" + "partner":"7oul" }, { "sim":262.0, - "partner":"6sgu" + "partner":"4u8v" }, { "sim":262.0, - "partner":"7oul" + "partner":"7b8t" }, { "sim":262.0, - "partner":"5nc5" + "partner":"6zo9" }, { "sim":262.0, - "partner":"6zo9" + "partner":"6zog" }, { "sim":262.0, - "partner":"6zog" + "partner":"5nc5" }, { "sim":262.0, - "partner":"7b8t" + "partner":"7oum" }, { "sim":262.0, @@ -1041077,23 +1050720,23 @@ }, { "sim":262.0, - "partner":"7oum" + "partner":"5en5" }, { "sim":262.0, - "partner":"5en5" + "partner":"6zoa" }, { "sim":262.0, - "partner":"4u8y" + "partner":"6zoh" }, { "sim":262.0, - "partner":"6zoa" + "partner":"4u8y" }, { "sim":262.0, - "partner":"6zoh" + "partner":"6sgr" }, { "sim":262.0, @@ -1041109,7 +1050752,7 @@ }, { "sim":262.0, - "partner":"6sgr" + "partner":"6zob" }, { "sim":262.0, @@ -1041117,16 +1050760,28 @@ }, { "sim":262.0, - "partner":"4hrm" + "partner":"5eno" }, { "sim":262.0, - "partner":"5ma4" + "partner":"6zo5" + }, + { + "sim":262.0, + "partner":"6q4n" + }, + { + "sim":262.0, + "partner":"4hrm" }, { "sim":262.0, "partner":"5mak" }, + { + "sim":262.0, + "partner":"5ma4" + }, { "sim":262.0, "partner":"5ma5" @@ -1041155,30 +1050810,18 @@ "sim":259.0, "partner":"6bbn" }, - { - "sim":259.0, - "partner":"7yz0" - }, { "sim":259.0, "partner":"6mzf" }, { "sim":259.0, - "partner":"7yz1" - }, - { - "sim":259.0, - "partner":"7z01" + "partner":"6mze" }, { "sim":259.0, "partner":"5nqt" }, - { - "sim":259.0, - "partner":"6mze" - }, { "sim":259.0, "partner":"7yz2" @@ -1041189,11 +1050832,11 @@ }, { "sim":259.0, - "partner":"5nqu" + "partner":"7ac5" }, { "sim":259.0, - "partner":"7ac5" + "partner":"5nqu" }, { "sim":259.0, @@ -1041205,11 +1050848,11 @@ }, { "sim":259.0, - "partner":"4lnu" + "partner":"7yz6" }, { "sim":259.0, - "partner":"7yz6" + "partner":"4lnu" }, { "sim":259.0, @@ -1041217,19 +1050860,19 @@ }, { "sim":259.0, - "partner":"4drx" + "partner":"6zwb" }, { "sim":259.0, - "partner":"5eib" + "partner":"4drx" }, { "sim":259.0, - "partner":"5nm5" + "partner":"5eib" }, { "sim":259.0, - "partner":"6zwb" + "partner":"5nm5" }, { "sim":259.0, @@ -1041243,6 +1050886,18 @@ "sim":259.0, "partner":"7yyz" }, + { + "sim":259.0, + "partner":"7yz0" + }, + { + "sim":259.0, + "partner":"7yz1" + }, + { + "sim":259.0, + "partner":"7z01" + }, { "sim":259.0, "partner":"5fin" @@ -1041277,11 +1050932,11 @@ }, { "sim":256.0, - "partner":"8p9e" + "partner":"8p9c" }, { "sim":256.0, - "partner":"8p9c" + "partner":"8p9e" }, { "sim":256.0, @@ -1041317,11 +1050972,11 @@ }, { "sim":254.0, - "partner":"7pjf" + "partner":"6s8l" }, { "sim":254.0, - "partner":"6s8l" + "partner":"7pjf" }, { "sim":254.0, @@ -1041519,10 +1051174,6 @@ "sim":239.0, "partner":"7p3i" }, - { - "sim":239.0, - "partner":"8g4f" - }, { "sim":239.0, "partner":"8g42" @@ -1041539,6 +1051190,10 @@ "sim":239.0, "partner":"8g3k" }, + { + "sim":239.0, + "partner":"8g4f" + }, { "sim":238.0, "partner":"8dw2" @@ -1041585,11 +1051240,11 @@ }, { "sim":230.0, - "partner":"3q9n" + "partner":"3q9u" }, { "sim":230.0, - "partner":"3q9u" + "partner":"3q9n" }, { "sim":229.0, @@ -1041605,11 +1051260,11 @@ }, { "sim":228.0, - "partner":"6mog" + "partner":"6moh" }, { "sim":228.0, - "partner":"6moh" + "partner":"6mog" }, { "sim":226.0, @@ -1041627,10 +1051282,6 @@ "sim":221.0, "partner":"5aq7" }, - { - "sim":213.0, - "partner":"7pd8" - }, { "sim":213.0, "partner":"7pdd" @@ -1041643,6 +1051294,10 @@ "sim":213.0, "partner":"7pdh" }, + { + "sim":213.0, + "partner":"7pd8" + }, { "sim":212.0, "partner":"6moj" @@ -1041709,15 +1051364,15 @@ }, { "sim":188.0, - "partner":"6d66" + "partner":"2xzd" }, { "sim":188.0, - "partner":"6d67" + "partner":"6d66" }, { "sim":188.0, - "partner":"2xzd" + "partner":"6d67" }, { "sim":184.0, @@ -1041753,23 +1051408,23 @@ }, { "sim":120.0, - "partner":"7tw6" + "partner":"8csl" }, { "sim":120.0, - "partner":"7v0k" + "partner":"7tw6" }, { "sim":120.0, - "partner":"8csl" + "partner":"7v0k" }, { "sim":120.0, - "partner":"7v0s" + "partner":"8csv" }, { "sim":120.0, - "partner":"8csv" + "partner":"7v0s" }, { "sim":120.0, @@ -1041777,11 +1051432,11 @@ }, { "sim":120.0, - "partner":"7uzu" + "partner":"8cte" }, { "sim":120.0, - "partner":"8cte" + "partner":"7uzu" }, { "sim":120.0, @@ -1041871,10 +1051526,6 @@ "sim":110.0, "partner":"5gp7" }, - { - "sim":109.0, - "partner":"5vhj" - }, { "sim":109.0, "partner":"5vhh" @@ -1041905,15 +1051556,15 @@ }, { "sim":109.0, - "partner":"5vhp" + "partner":"5vhj" }, { "sim":109.0, - "partner":"7vxv" + "partner":"5vhp" }, { "sim":109.0, - "partner":"1uoh" + "partner":"7vxv" }, { "sim":109.0, @@ -1041923,6 +1051574,10 @@ "sim":109.0, "partner":"7vxw" }, + { + "sim":109.0, + "partner":"1uoh" + }, { "sim":109.0, "partner":"7vy4" @@ -1041933,11 +1051588,11 @@ }, { "sim":109.0, - "partner":"1tr4" + "partner":"7vy7" }, { "sim":109.0, - "partner":"7vy7" + "partner":"1tr4" }, { "sim":109.0, @@ -1041965,15 +1051620,15 @@ }, { "sim":108.0, - "partner":"3aji" + "partner":"2dvw" }, { "sim":108.0, - "partner":"2dvw" + "partner":"2dwz" }, { "sim":108.0, - "partner":"2dwz" + "partner":"3aji" }, { "sim":107.0, @@ -1042073,15 +1051728,15 @@ }, { "sim":94.0, - "partner":"1bu9" + "partner":"1mx6" }, { "sim":94.0, - "partner":"1g3n" + "partner":"1bu9" }, { "sim":94.0, - "partner":"1mx6" + "partner":"1g3n" }, { "sim":94.0, @@ -1042089,11 +1051744,11 @@ }, { "sim":94.0, - "partner":"4cym" + "partner":"4cz2" }, { "sim":94.0, - "partner":"4cz2" + "partner":"4cym" }, { "sim":93.0, @@ -1042113,11 +1051768,11 @@ }, { "sim":92.0, - "partner":"7el6" + "partner":"7cng" }, { "sim":92.0, - "partner":"7cng" + "partner":"7el6" }, { "sim":92.0, @@ -1042127,6 +1051782,14 @@ "sim":92.0, "partner":"8v0e" }, + { + "sim":92.0, + "partner":"8wqg" + }, + { + "sim":92.0, + "partner":"8wqe" + }, { "sim":92.0, "partner":"8wqh" @@ -1042155,14 +1051818,6 @@ "sim":92.0, "partner":"8wqd" }, - { - "sim":92.0, - "partner":"8wqg" - }, - { - "sim":92.0, - "partner":"8wqe" - }, { "sim":92.0, "partner":"8je1" @@ -1042257,11 +1051912,11 @@ }, { "sim":89.0, - "partner":"8q7r" + "partner":"8pql" }, { "sim":89.0, - "partner":"8pql" + "partner":"8q7r" }, { "sim":88.0, @@ -1042453,19 +1052108,19 @@ }, { "sim":79.0, - "partner":"3aaa" + "partner":"7df7" }, { "sim":79.0, - "partner":"7dsb" + "partner":"7dsa" }, { "sim":79.0, - "partner":"7df7" + "partner":"7dsb" }, { "sim":79.0, - "partner":"7dsa" + "partner":"3aaa" }, { "sim":79.0, @@ -1042487,14 +1052142,6 @@ "sim":79.0, "partner":"8y1u" }, - { - "sim":79.0, - "partner":"6m11" - }, - { - "sim":79.0, - "partner":"6m12" - }, { "sim":79.0, "partner":"6m13" @@ -1042519,6 +1052166,14 @@ "sim":79.0, "partner":"4o1p" }, + { + "sim":79.0, + "partner":"6m11" + }, + { + "sim":79.0, + "partner":"6m12" + }, { "sim":78.0, "partner":"8zq3" @@ -1042551,10 +1052206,6 @@ "sim":76.0, "partner":"5z2m" }, - { - "sim":76.0, - "partner":"6v9x" - }, { "sim":76.0, "partner":"6v9y" @@ -1042567,6 +1052218,10 @@ "sim":76.0, "partner":"6v9w" }, + { + "sim":76.0, + "partner":"6v9x" + }, { "sim":76.0, "partner":"7or0" @@ -1042645,15 +1052300,15 @@ }, { "sim":70.0, - "partner":"2a5e" + "partner":"1dc2" }, { "sim":70.0, - "partner":"1dc2" + "partner":"1a5e" }, { "sim":70.0, - "partner":"1a5e" + "partner":"2a5e" }, { "sim":70.0, @@ -1042683,10 +1052338,6 @@ "sim":70.0, "partner":"5wo6" }, - { - "sim":70.0, - "partner":"5iwr" - }, { "sim":70.0, "partner":"5iwt" @@ -1042741,11 +1052392,11 @@ }, { "sim":70.0, - "partner":"5wo7" + "partner":"5iwr" }, { "sim":70.0, - "partner":"6o1p" + "partner":"5wo7" }, { "sim":70.0, @@ -1042785,11 +1052436,7 @@ }, { "sim":70.0, - "partner":"7t6m" - }, - { - "sim":70.0, - "partner":"8ffn" + "partner":"6o1p" }, { "sim":70.0, @@ -1042825,15 +1052472,19 @@ }, { "sim":70.0, - "partner":"8tf2" + "partner":"7t6j" }, { "sim":70.0, - "partner":"7t6j" + "partner":"7t6r" }, { "sim":70.0, - "partner":"7t6r" + "partner":"8tf2" + }, + { + "sim":70.0, + "partner":"7t6k" }, { "sim":70.0, @@ -1042841,7 +1052492,7 @@ }, { "sim":70.0, - "partner":"7t6k" + "partner":"7t6l" }, { "sim":70.0, @@ -1042849,16 +1052500,20 @@ }, { "sim":70.0, - "partner":"7t6l" + "partner":"7t6m" }, { - "sim":69.0, - "partner":"1k1a" + "sim":70.0, + "partner":"8ffn" }, { "sim":69.0, "partner":"1k1b" }, + { + "sim":69.0, + "partner":"1k1a" + }, { "sim":68.0, "partner":"4f1p" @@ -1042931,10 +1052586,6 @@ "sim":62.0, "partner":"8sp8" }, - { - "sim":62.0, - "partner":"7k4a" - }, { "sim":62.0, "partner":"7k4b" @@ -1042957,7 +1052608,7 @@ }, { "sim":62.0, - "partner":"7s89" + "partner":"7k4a" }, { "sim":62.0, @@ -1042973,7 +1052624,7 @@ }, { "sim":62.0, - "partner":"6e2f" + "partner":"7s89" }, { "sim":62.0, @@ -1042985,7 +1052636,7 @@ }, { "sim":62.0, - "partner":"6bo9" + "partner":"6e2f" }, { "sim":62.0, @@ -1043003,6 +1052654,10 @@ "sim":62.0, "partner":"6bo8" }, + { + "sim":62.0, + "partner":"6bo9" + }, { "sim":62.0, "partner":"9cuj" @@ -1043041,11 +1052696,11 @@ }, { "sim":61.0, - "partner":"9cuh" + "partner":"9cui" }, { "sim":61.0, - "partner":"9cui" + "partner":"9cuh" }, { "sim":59.0, @@ -1043077,11 +1052732,11 @@ }, { "sim":56.0, - "partner":"7ttr" + "partner":"7tts" }, { "sim":56.0, - "partner":"7tts" + "partner":"7ttr" }, { "sim":55.0, @@ -1043464,105 +1053119,105 @@ ], "subtitle":"De novo designed bbf-14 beta barrel with computationally designed bbf-14_b4 binder", "tags":[ + "de novo protein", "binder", "computational", - "de novo protein", - "bbf-14", - "beta barrel" + "beta barrel", + "bbf-14" ], "keywords":[ - "work", - "aav", - "utilize", - "gene", - "represents", - "reducing", - "including", - "designed", - "determine", - "cas9", - "redirect", - "towards", - "potential", - "features", - "lastly", - "interactions", - "however", "affinity", - "biotechnology", - "therapeutic", - "rates", - "pipeline", - "even", + "structural", + "key", + "experimental", + "modulating", + "core", "capsids", - "without", + "weights", + "delivery", "ppis", + "foodborne", + "protein", + "successfully", + "binding", + "bacterial", + "novo", + "ige", + "utilize", + "birch", + "however", + "showcase", + "editing", + "represents", + "biological", + "gene", + "automated", + "targets", + "immense", + "pipeline", + "makes", + "optimization", + "approach", + "sites", "proteins", - "receptors", - "cell", - "de", + "advancement", + "success", "binder", - "successfully", - "processes", - "targeted", - "binders", - "leverages", - "cytotoxicity", + "features", + "reducing", "nanomolar", - "therapeutics", - "weights", - "complexity", - "foodborne", + "computational", + "rates", + "including", + "1", + "set", + "surface", "need", - "makes", - "alphafold2", + "design", + "challenging", + "work", + "binders", + "diverse", + "even", + "therapeutics", "functional", - "editing", + "absence", + "processes", + "potential", + "samples", + "therapeutic", + "complexity", + "cell", + "cytotoxicity", + "redirect", "common", - "generate", - "screening", - "1", - "optimization", - "challenging", - "activity", - "advancement", - "design", - "core", - "birch", "present", - "modulating", - "surface", - "biological", - "key", - "known", - "allergen", - "structural", - "nucleases", - "sites", - "diverse", - "delivery", - "showcase", - "bacterial", - "one", - "approach", - "novo", - "success", - "experimental", + "determine", + "screening", "enterotoxin", - "allergens", - "samples", - "absence", - "automated", + "designed", "bindcraft", - "set", - "significant", - "protein", - "targets", - "ige", - "computational", - "immense", + "alphafold2", + "one", + "leverages", + "aav", + "targeted", + "receptors", + "de", + "nucleases", + "without", + "interactions", + "known", + "lastly", + "towards", + "activity", + "allergens", + "cas9", + "allergen", "diagnostics", - "binding" + "generate", + "biotechnology", + "significant" ], "release_date":"2024-12-18", "publication":"\"BindCraft: one-shot design of functional protein binders\", Biorxiv", @@ -1043774,107 +1053429,107 @@ ], "subtitle":"Der f 21 dust mite allergen with computationally designed derf21_b10 binder", "tags":[ - "binder", - "dust mite", - "computational", "der f 21", + "de novo", "de novo protein", "allergen", - "de novo" + "dust mite", + "computational", + "binder" ], "keywords":[ - "work", - "aav", - "utilize", - "gene", - "represents", - "reducing", - "including", - "designed", - "determine", - "cas9", - "redirect", - "towards", - "potential", - "features", - "lastly", - "interactions", - "however", "affinity", - "biotechnology", - "therapeutic", - "rates", - "pipeline", - "even", + "structural", + "key", + "experimental", + "modulating", + "core", "capsids", - "without", + "weights", + "delivery", "ppis", + "foodborne", + "protein", + "successfully", + "binding", + "bacterial", + "novo", + "ige", + "utilize", + "birch", + "however", + "showcase", + "editing", + "represents", + "biological", + "gene", + "automated", + "targets", + "immense", + "pipeline", + "makes", + "optimization", + "approach", + "sites", "proteins", - "receptors", - "cell", - "de", + "advancement", + "success", "binder", - "successfully", - "processes", - "targeted", - "binders", - "leverages", - "cytotoxicity", + "features", + "reducing", "nanomolar", - "therapeutics", - "weights", - "complexity", - "foodborne", + "computational", + "rates", + "including", + "1", + "set", + "surface", "need", - "makes", - "alphafold2", + "design", + "challenging", + "work", + "binders", + "diverse", + "even", + "therapeutics", "functional", - "editing", + "absence", + "processes", + "potential", + "samples", + "therapeutic", + "complexity", + "cell", + "cytotoxicity", + "redirect", "common", - "generate", - "screening", - "1", - "optimization", - "challenging", - "activity", - "advancement", - "design", - "core", - "birch", "present", - "modulating", - "surface", - "biological", - "key", - "known", - "allergen", - "structural", - "nucleases", - "sites", - "diverse", - "delivery", - "showcase", - "bacterial", - "one", - "approach", - "novo", - "success", - "experimental", + "determine", + "screening", "enterotoxin", - "allergens", - "samples", - "absence", - "automated", + "designed", "bindcraft", - "set", - "significant", - "protein", - "targets", - "ige", - "computational", - "immense", + "alphafold2", + "one", + "leverages", + "aav", + "targeted", + "receptors", + "de", + "nucleases", + "without", + "interactions", + "known", + "lastly", + "towards", + "activity", + "allergens", + "cas9", + "allergen", "diagnostics", - "binding" + "generate", + "biotechnology", + "significant" ], "release_date":"2024-12-18", "publication":"\"BindCraft: one-shot design of functional protein binders\", Biorxiv", @@ -1044082,107 +1053737,107 @@ ], "subtitle":"Dust mite allergen der f 7 with computationally designed derf7_b2 binder", "tags":[ - "binder", - "dust mite", - "computational", + "de novo", "de novo protein", "allergen", - "de novo", - "der f 7" + "der f 7", + "dust mite", + "computational", + "binder" ], "keywords":[ - "work", - "aav", - "utilize", - "gene", - "represents", - "reducing", - "including", - "designed", - "determine", - "cas9", - "redirect", - "towards", - "potential", - "features", - "lastly", - "interactions", - "however", "affinity", - "biotechnology", - "therapeutic", - "rates", - "pipeline", - "even", + "structural", + "key", + "experimental", + "modulating", + "core", "capsids", - "without", + "weights", + "delivery", "ppis", + "foodborne", + "protein", + "successfully", + "binding", + "bacterial", + "novo", + "ige", + "utilize", + "birch", + "however", + "showcase", + "editing", + "represents", + "biological", + "gene", + "automated", + "targets", + "immense", + "pipeline", + "makes", + "optimization", + "approach", + "sites", "proteins", - "receptors", - "cell", - "de", + "advancement", + "success", "binder", - "successfully", - "processes", - "targeted", - "binders", - "leverages", - "cytotoxicity", + "features", + "reducing", "nanomolar", - "therapeutics", - "weights", - "complexity", - "foodborne", + "computational", + "rates", + "including", + "1", + "set", + "surface", "need", - "makes", - "alphafold2", + "design", + "challenging", + "work", + "binders", + "diverse", + "even", + "therapeutics", "functional", - "editing", + "absence", + "processes", + "potential", + "samples", + "therapeutic", + "complexity", + "cell", + "cytotoxicity", + "redirect", "common", - "generate", - "screening", - "1", - "optimization", - "challenging", - "activity", - "advancement", - "design", - "core", - "birch", "present", - "modulating", - "surface", - "biological", - "key", - "known", - "allergen", - "structural", - "nucleases", - "sites", - "diverse", - "delivery", - "showcase", - "bacterial", - "one", - "approach", - "novo", - "success", - "experimental", + "determine", + "screening", "enterotoxin", - "allergens", - "samples", - "absence", - "automated", + "designed", "bindcraft", - "set", - "significant", - "protein", - "targets", - "ige", - "computational", - "immense", + "alphafold2", + "one", + "leverages", + "aav", + "targeted", + "receptors", + "de", + "nucleases", + "without", + "interactions", + "known", + "lastly", + "towards", + "activity", + "allergens", + "cas9", + "allergen", "diagnostics", - "binding" + "generate", + "biotechnology", + "significant" ], "release_date":"2024-12-18", "publication":"\"BindCraft: one-shot design of functional protein binders\", Biorxiv", @@ -1044394,107 +1054049,107 @@ ], "subtitle":"Dust mite allergen der f 7 with computationally designed derf7_b2 binder", "tags":[ - "binder", - "dust mite", - "computational", + "de novo", "de novo protein", "allergen", - "de novo", - "der f 7" + "der f 7", + "dust mite", + "computational", + "binder" ], "keywords":[ - "work", - "aav", - "utilize", - "gene", - "represents", - "reducing", - "including", - "designed", - "determine", - "cas9", - "redirect", - "towards", - "potential", - "features", - "lastly", - "interactions", - "however", "affinity", - "biotechnology", - "therapeutic", - "rates", - "pipeline", - "even", + "structural", + "key", + "experimental", + "modulating", + "core", "capsids", - "without", + "weights", + "delivery", "ppis", + "foodborne", + "protein", + "successfully", + "binding", + "bacterial", + "novo", + "ige", + "utilize", + "birch", + "however", + "showcase", + "editing", + "represents", + "biological", + "gene", + "automated", + "targets", + "immense", + "pipeline", + "makes", + "optimization", + "approach", + "sites", "proteins", - "receptors", - "cell", - "de", + "advancement", + "success", "binder", - "successfully", - "processes", - "targeted", - "binders", - "leverages", - "cytotoxicity", + "features", + "reducing", "nanomolar", - "therapeutics", - "weights", - "complexity", - "foodborne", + "computational", + "rates", + "including", + "1", + "set", + "surface", "need", - "makes", - "alphafold2", + "design", + "challenging", + "work", + "binders", + "diverse", + "even", + "therapeutics", "functional", - "editing", + "absence", + "processes", + "potential", + "samples", + "therapeutic", + "complexity", + "cell", + "cytotoxicity", + "redirect", "common", - "generate", - "screening", - "1", - "optimization", - "challenging", - "activity", - "advancement", - "design", - "core", - "birch", "present", - "modulating", - "surface", - "biological", - "key", - "known", - "allergen", - "structural", - "nucleases", - "sites", - "diverse", - "delivery", - "showcase", - "bacterial", - "one", - "approach", - "novo", - "success", - "experimental", + "determine", + "screening", "enterotoxin", - "allergens", - "samples", - "absence", - "automated", + "designed", "bindcraft", - "set", - "significant", - "protein", - "targets", - "ige", - "computational", - "immense", + "alphafold2", + "one", + "leverages", + "aav", + "targeted", + "receptors", + "de", + "nucleases", + "without", + "interactions", + "known", + "lastly", + "towards", + "activity", + "allergens", + "cas9", + "allergen", "diagnostics", - "binding" + "generate", + "biotechnology", + "significant" ], "release_date":"2024-12-18", "publication":"\"BindCraft: one-shot design of functional protein binders\", Biorxiv", @@ -1044600,10 +1054255,10 @@ ], "subtitle":"De novo designed beta barrel fold bbf-14", "tags":[ - "peg", - "beta barrel", "de novo protein", - "de novo" + "beta barrel", + "de novo", + "peg" ], "keywords":[ "description", @@ -1044715,139 +1054370,139 @@ ], "subtitle":"De novo designed cell-penetrating peptide self-assembly featuring distinctive tertiary structure", "tags":[ - "cell-penetration", "amphipathic peptides", - "cpp", + "cell-penetration", "de novo protein", - "protein design", - "peptide self-assembly" + "cpp", + "peptide self-assembly", + "protein design" ], "keywords":[ - "enantiomers", - "analysis", - "amphipathic", - "oligomers", - "evidence", - "propensity", - "significance", - "link", - "dsc", - "low", "trimer", - "challenge", + "paralleling", + "pure", + "dimers", + "conclusion", + "capability", + "hydrophobic", + "concentrations", + "core", "acid", - "lacking", - "crystallography", - "including", - "peptide", - "underscoring", + "scanning", + "calorimetry", + "various", + "protein", + "study", + "mass", "lkklclklkklcklag", - "hexamers", - "f\u00f6rster", - "enhanced", - "suggested", - "structure", - "penetration", - "fret", - "involve", - "acceptor", - "instability", - "oligomer", - "quaternary", - "crucial", - "direct", - "concentrations", - "derivatives", - "considering", + "showed", + "photobleaching", "notion", - "poses", - "differential", - "proteins", + "confirmed", + "novo", + "cells", + "acceptor", + "resonance", "forms", + "recent", + "related", + "stable", + "focused", + "using", + "formed", + "interest", "exhibited", - "cell", - "specifically", - "de", - "advancements", - "yet", - "highlighting", - "particularly", - "attention", - "nanomolar", - "structures", - "conclusion", - "biopharmaceuticals", + "due", + "dimer", "mixture", + "particularly", "enantiomeric", - "atomic", - "particular", - "function", - "resonance", - "showed", - "revealed", - "native", - "compared", - "molecules", - "status", - "capability", + "crucial", + "hexamers", + "finding", + "quaternary", + "considering", "exploring", - "previously", - "properties", - "functional", - "amino", + "concrete", + "propensity", + "proteins", "large", - "associated", - "oligomerization", - "scanning", - "finding", - "interest", - "dimer", + "low", + "evidence", + "supported", + "penetration", + "status", + "nanomolar", + "importance", + "including", + "characterize", + "peptide", "promotes", - "photobleaching", - "transfer", + "direct", "behavior", - "provides", - "calorimetry", "design", - "core", - "intriguing", - "supported", - "using", - "states", - "hydrophobic", - "recent", - "sequence", - "techniques", + "enhanced", "energy", + "enantiomers", + "compared", + "atomic", + "provides", + "functional", + "yet", + "properties", + "derivatives", + "experiments", + "instability", + "underscoring", + "cell", + "oligomerization", + "amino", "bridged", - "concrete", - "abilities", - "paralleling", "formation", - "cells", - "designs", - "importance", - "study", - "novo", - "stable", - "experiments", + "oligomer", + "highlighting", + "states", + "sequence", + "involve", + "biopharmaceuticals", "peptides", - "focused", - "confirmed", - "characterize", - "due", - "dimers", - "sought", + "suggested", + "intriguing", "achieving", - "significant", - "protein", - "spectrometry", + "abilities", + "techniques", + "dsc", + "associated", + "amphipathic", + "fret", "ms", - "various", - "pure", - "mass", - "formed", - "related" + "analysis", + "particular", + "revealed", + "significance", + "advancements", + "sought", + "poses", + "structures", + "de", + "link", + "oligomers", + "previously", + "differential", + "specifically", + "structure", + "crystallography", + "attention", + "function", + "f\u00f6rster", + "molecules", + "native", + "lacking", + "designs", + "challenge", + "spectrometry", + "transfer", + "significant" ], "release_date":"2024-09-11", "publication":"\"De Novo Designed Cell-Penetrating Peptide Self-Assembly Featuring Distinctive Tertiary Structure\", Acs Omega, 9, 32991-32999", @@ -1044942,139 +1054597,139 @@ ], "subtitle":"De novo designed cell-penetrating peptide self-assembly featuring distinctive tertiary structure", "tags":[ - "cell-penetration", "amphipathic peptides", - "cpp", + "cell-penetration", "de novo protein", - "protein design", - "peptide self-assembly" + "cpp", + "peptide self-assembly", + "protein design" ], "keywords":[ - "enantiomers", - "analysis", - "amphipathic", - "oligomers", - "evidence", - "propensity", - "significance", - "link", - "dsc", - "low", "trimer", - "challenge", + "paralleling", + "pure", + "dimers", + "conclusion", + "capability", + "hydrophobic", + "concentrations", + "core", "acid", - "lacking", - "crystallography", - "including", - "peptide", - "underscoring", + "scanning", + "calorimetry", + "various", + "protein", + "study", + "mass", "lkklclklkklcklag", - "hexamers", - "f\u00f6rster", - "enhanced", - "suggested", - "structure", - "penetration", - "fret", - "involve", - "acceptor", - "instability", - "oligomer", - "quaternary", - "crucial", - "direct", - "concentrations", - "derivatives", - "considering", + "showed", + "photobleaching", "notion", - "poses", - "differential", - "proteins", + "confirmed", + "novo", + "cells", + "acceptor", + "resonance", "forms", + "recent", + "related", + "stable", + "focused", + "using", + "formed", + "interest", "exhibited", - "cell", - "specifically", - "de", - "advancements", - "yet", - "highlighting", - "particularly", - "attention", - "nanomolar", - "structures", - "conclusion", - "biopharmaceuticals", + "due", + "dimer", "mixture", + "particularly", "enantiomeric", - "atomic", - "particular", - "function", - "resonance", - "showed", - "revealed", - "native", - "compared", - "molecules", - "status", - "capability", + "crucial", + "hexamers", + "finding", + "quaternary", + "considering", "exploring", - "previously", - "properties", - "functional", - "amino", + "concrete", + "propensity", + "proteins", "large", - "associated", - "oligomerization", - "scanning", - "finding", - "interest", - "dimer", + "low", + "evidence", + "supported", + "penetration", + "status", + "nanomolar", + "importance", + "including", + "characterize", + "peptide", "promotes", - "photobleaching", - "transfer", + "direct", "behavior", - "provides", - "calorimetry", "design", - "core", - "intriguing", - "supported", - "using", - "states", - "hydrophobic", - "recent", - "sequence", - "techniques", + "enhanced", "energy", + "enantiomers", + "compared", + "atomic", + "provides", + "functional", + "yet", + "properties", + "derivatives", + "experiments", + "instability", + "underscoring", + "cell", + "oligomerization", + "amino", "bridged", - "concrete", - "abilities", - "paralleling", "formation", - "cells", - "designs", - "importance", - "study", - "novo", - "stable", - "experiments", + "oligomer", + "highlighting", + "states", + "sequence", + "involve", + "biopharmaceuticals", "peptides", - "focused", - "confirmed", - "characterize", - "due", - "dimers", - "sought", + "suggested", + "intriguing", "achieving", - "significant", - "protein", - "spectrometry", + "abilities", + "techniques", + "dsc", + "associated", + "amphipathic", + "fret", "ms", - "various", - "pure", - "mass", - "formed", - "related" + "analysis", + "particular", + "revealed", + "significance", + "advancements", + "sought", + "poses", + "structures", + "de", + "link", + "oligomers", + "previously", + "differential", + "specifically", + "structure", + "crystallography", + "attention", + "function", + "f\u00f6rster", + "molecules", + "native", + "lacking", + "designs", + "challenge", + "spectrometry", + "transfer", + "significant" ], "release_date":"2024-09-04", "publication":"\"De Novo Designed Cell-Penetrating Peptide Self-Assembly Featuring Distinctive Tertiary Structure\", Acs Omega, 9, 32991-32999", @@ -1045197,90 +1054852,90 @@ ], "subtitle":"Helix-loop-helix peptide (vs42-lr3) in complex with vegf-a", "tags":[ - "inhibitor", - "immune system-de novo protein complex", + "complex", "de novo protein", - "immune system\/de novo protein", + "inhibitor", "helix-loop-helix", - "complex" + "immune system-de novo protein complex", + "immune system\/de novo protein" ], "keywords":[ - "analysis", - "valuable", - "advancing", - "molecular", - "monomeric", - "play", - "whole", - "growth", - "higher", - "combinatorial", - "rigidity", - "generate", - "report", - "murine", - "stable", - "resolution", - "therapies", - "xenograft", - "thermodynamic", - "human", - "peptide", - "peptides", + "affinity", "designed", - "well", - "crucial", - "modality", - "region", - "endothelial", "screened", - "simulations", - "provide", - "colorectal", - "crystal", - "site", + "complex", "suppressed", - "scaffold", - "vascular", - "interestingly", - "model", - "design", + "murine", "vegf", + "analysis", + "interestingly", "mutagenesis", - "findings", - "protein", - "bound", - "using", + "inhibited", + "revealed", + "molecular", "dynamic", - "complex", - "affected", - "surface", - "tumor", - "structure", - "high", + "design", + "role", + "structural", + "insights", + "resolution", + "loop", "structurally", - "revealed", - "emerged", + "well", "hlh", - "insights", + "xenograft", + "first", + "structure", + "monomeric", + "crucial", + "report", + "provide", + "new", + "affected", + "play", + "therapeutic", + "findings", + "model", "recently", - "increase", - "could", - "turned", + "therapies", + "vascular", + "protein", "adopted", - "affinity", - "cancer", - "therapeutic", - "first", - "inhibited", + "advancing", + "endothelial", + "bound", "binding", - "structural", - "role", - "loop", + "valuable", + "interaction", + "modality", + "thermodynamic", + "simulations", + "site", + "high", + "tumor", + "surface", + "increase", + "combinatorial", + "scaffold", + "peptides", "crystals", "libraries", - "new", - "interaction" + "rigidity", + "crystal", + "region", + "whole", + "stable", + "higher", + "human", + "turned", + "colorectal", + "growth", + "cancer", + "using", + "generate", + "peptide", + "could", + "emerged" ], "release_date":"2024-12-25", "publication":"\"Structural insights into molecular-targeting helix-loop-helix peptide against vascular endothelial growth factor-A\", Biochem Biophys Res Commun, 734, 150749", @@ -1045408,93 +1055063,93 @@ ], "subtitle":"Helix-loop-helix peptide (m49) in complex with vegf-a", "tags":[ - "inhibitor", - "immune system-de novo protein complex", + "complex", "de novo protein", - "immune system\/de novo protein", + "inhibitor", "helix-loop-helix", - "complex" + "immune system-de novo protein complex", + "immune system\/de novo protein" ], "keywords":[ - "work", - "analysis", - "studies", - "specificity", - "biochemical", - "peptide", - "m49", - "interacts", - "receptor", - "illustrated", - "crystal", - "target", - "conjugates", - "basis", - "structure", - "conformationally", - "hlh", - "alternative", - "forces", - "induce", - "growth", - "cell", - "\u00e5", - "used", - "endothelial", - "constrained", "made", - "vascular", - "pdcs", + "molecular", "driving", - "showed", - "cellular", - "biology", + "constrained", + "resolution", "carrier", - "research", - "contribute", - "provided", - "targeting", - "molecular", + "well", + "information", + "extracellular", "via", - "internalization", - "chemical", - "resolution", + "provided", + "delivery", + "new", + "vascular", + "protein", + "study", + "biochemical", + "binding", + "cellular", + "showed", + "pdcs", "thermodynamic", - "information", - "would", - "mode", - "endocytic", - "design", + "crystal", + "growth", "using", - "present", + "receptor", + "induce", + "complex", + "alternative", + "specificity", + "hlh", + "basis", + "endothelial", + "illustrated", + "conjugates", + "chemical", + "tight", + "peptide", "surface", - "extracellular", - "high", + "vegf", + "grown", + "design", + "intracellular", "microgravity", + "work", + "used", + "endocytic", + "research", + "biology", + "environment", + "targeting", + "addition", + "cell", + "mode", + "forces", "formation", - "advancing", - "delivery", - "grown", + "interacts", "pathway", + "peptides", + "developed", + "present", + "mechanism", + "advancing", + "analysis", "mutational", - "study", - "tight", - "intracellular", + "contribute", + "conformationally", + "\u00e5", + "structure", + "m49", + "target", "drug", - "human", - "peptides", - "discovery", - "well", + "would", "uptake", - "addition", - "mechanism", - "vegf", - "protein", - "complex", - "environment", - "binding", - "developed", - "new" + "high", + "internalization", + "discovery", + "studies", + "human" ], "release_date":"2024-12-11", "publication":"\"Structural Insights into Helix-Loop-Helix Peptides for \"Ligand-Targeting\" Intracellular Drug Delivery via VEGF Receptor-Mediated Endocytosis\", Biochem.Biophys.Res.Commun., 741, 150980-150980", @@ -1045523,7 +1055178,7 @@ "synthesis_comment":"", "review":true, "previous_design":"9ju1", - "next_design":"1abz", + "next_design":"9mrf", "seq_thr_sim_designed":[ { "sim":53.0, @@ -1045557,5 +1055212,105 @@ "review_comment":[ "" ] + }, + { + "pdb":"9mrf", + "picture_path":"https:\/\/cdn.rcsb.org\/images\/structures\/9mrf_assembly-1.jpeg", + "chains":[ + { + "chain_id":"A,B", + "chain_source":"synthetic construct", + "chain_type":"D", + "chain_seq_unnat":"SAASDLDELLWVIAVTIFGLVLIASILKFYK", + "chain_seq_nat":"SAASDLDELLWVIAVTIFGLVLIASILKFYK", + "chain_length":31 + } + ], + "authors":[ + { + "forename":"M.", + "surname":"Mravic" + }, + { + "forename":"M.", + "surname":"Zhang" + }, + { + "forename":"C.T.", + "surname":"Anderson" + } + ], + "classification":"unknown", + "classification_suggested":[ + + ], + "classification_suggested_reason":[ + + ], + "subtitle":"De novo designed apolar residue motif transmembrane helix", + "tags":[ + "membrane protein", + "de novo protein", + "de novo design" + ], + "keywords":[ + "description", + "found" + ], + "release_date":"2025-01-22", + "publication":"To be published", + "publication_ref":{ + "DOI":"", + "PubMed":"", + "CSD":"", + "ISSN":"", + "ASTM":"" + }, + "publication_country":"", + "abstract":"No description found.", + "crystal_structure":{ + "length_a":"39.599", + "length_b":"48.745", + "length_c":"29.756", + "angle_a":"90.000", + "angle_b":"90.000", + "angle_g":"90.000" + }, + "symmetry":"P 2 2 21", + "exptl_method":[ + "X-RAY DIFFRACTION" + ], + "formula_weight":3412.066, + "synthesis_comment":"", + "review":true, + "previous_design":"9kku", + "next_design":"1abz", + "seq_thr_sim_designed":[ + + ], + "seq_thr_sim_natural":[ + + ], + "struct_thr_sim_designed":[ + + ], + "struct_thr_sim_natural":[ + + ], + "seq_max_sim_designed":[ + + ], + "seq_max_sim_natural":[ + + ], + "struct_max_sim_designed":[ + + ], + "struct_max_sim_natural":[ + + ], + "review_comment":[ + "" + ] } ] \ No newline at end of file diff --git a/frontend/src/Components/Title.elm b/frontend/src/Components/Title.elm index 6dc9e78..d7f8a32 100644 --- a/frontend/src/Components/Title.elm +++ b/frontend/src/Components/Title.elm @@ -97,5 +97,5 @@ footerArea = ] } ] - , row [ width <| fillPortion 1, centerX, padding 10 ] [ text <| "Date of last update: " ++ "2025-01-01" ] + , row [ width <| fillPortion 1, centerX, padding 10 ] [ text <| "Date of last update: " ++ "2025-02-01" ] ]