GAMMORA REPOSITORY

GAMMORA : GAte Monte-Carlo MOdel for RAdiotherapy

A full Varian TrueBeam STx Model for Gate v9.0/Geant4 with the following features:

• conversion DICOM RT PLAN to GATE macros (including dynamic plans such as VMAT, DCA...)
• the particle gun is a GAN (neural network) trained using the data provided by myVarian (i.e. IAEAphsp files based on Constantin et al.) . These GANs are created using gaga
• full geometry (MLC, jaws...). As the real geometry is confidential, the proposed model is slightly different than the real machine (but same dosmetric properties)

Please, read the user guide for installation, getting started and simple examples.

Authors

Jeremy Leste¹, Maxime Chauvin¹, Tony Younes¹, Sara Beilla¹, Luc Simon^1,2

(1)CRCT, Toulouse, France

(2)IUCT-Oncopole, Toulouse, France

Validation

Jeremy Leste¹, Alexia Delbaere¹, Imene Medjahed², Maxime Chauvin¹, Tony Younes¹, Sara Beilla¹, Luc Simon^1,2

(1)CRCT, Toulouse, France

(2)IUCT-Oncopole, Toulouse, France

Publications

Reference paper:

• Jeremy Leste, Tony Younes, Maxime Chauvin, Xavier Franceries, Alexia Delbaere, Laure Vieillevigne, Regis Ferrand, Manuel Bardies, Luc Simon, Technical note: GAMMORA, a free, open-source, and validated GATE-based model for Monte-Carlo simulations of the Varian TrueBeam, Physica Medica 89 (2021) 211–218,

The following studies were made using GAMMORA:

• J. Leste, I. Medjahed, M. Chauvin, T. Younes, L. Vieillevigne, R. Ferrand, X. Franceries, M. Bardies, L. Simon. A study of the interplay effect in Radiation Therapy using a Monte-Carlo model, Physica Medica 87, 73-82 (2021)

• T. Younes, M. Chauvin, A. Delbaere, J. Labour, V. Fonteny, L. Simon, G. Fares, and L. Vieillevigne, Towards the standardization of the absorbed dose report mode in high energy photon beams, Physics in Medicine and Biology 66 (2021).

• R. Barbeiro, L. Parent, L. Vieillevigne, R. Ferrand, and X. Franceries, Dosimetric performance of continuous EPID imaging in stereotactic treatment conditions, Physica Medica 78, 117–122 (2020)

• A. Delbaere, T. Younes, and L. Vieillevigne, On the conversion from dose-to-medium to dose-to-water in heterogeneous phantoms with Acuros XB and Monte Carlo calculations, Physics in Medicine and Biology 64 (2019).

• J. Leste, T. Younes, M. Chauvin, L. Vieillevigne, M. Bardies, X. Franceries, J. Nalis and L. Simon, 36 Monte Carlo simulation of absorbed dose distribution for electron beam using GATE/GEANT4, Physica Medica 56, 21 (2018)

• S. Beilla, T. Younes, L. Vieillevigne, M. Bardies, X. Franceries, and L. Simon, Monte-Carlo dose calculation in presence of low-density media: Application to lung SBRT treated during DIBH, Physica Medica 41, 46–52 (2017).

PhD Thesis

The subjects of these PhD thesis were to implement, improve, validate or use GAMMORA:

• J. Leste Implementation and clinic application of a Monte Carlo model of an external radiotherapy linear accelerator, PhD Thesis, Universite de Toulouse. Ph.D. thesis; Universite de Toulouse; 2020

• T. Younes Methodologie pour la determination de la dose absorbee dans le cas des petits champs avec et sans heterogeneites pour des faisceaux de photons de haute energie, PhD Thesis, Universite de Toulouse.Ph.D. thesis; Universite de Toulouse; 2018

• S. Beilla Modelisation Monte-Carlo d’un accelerateur lineaire pour la prise en compte des densites pulmonaires dans le calcul de la dose absorbee en Radiotherapie Stereotaxique, PhD Thesis, Universite deToulouse. Ph.D. thesis; Universite de Toulouse; 2016

Acknowledgements:

• This work is granted access to the HPC resources of CALMIP supercomputing center under the allocation 2016-P19001.

• This work was supported by the French National Cancer Institute (INCa) within the framework of the 2016 Physics Cancer Project: STEREPID

This repository is the last version of GAMMORA. Please read the user guide to start (this manual should be improved soon).

Next release will include absolute dose scaling, example with job splitting, example with target motion for interplay effect assessment and a easy to use GUI.