Problem with reproducing Ramos-Méndez et al. (2021)

[Alitmedical]

Simulation question

Dear users,

I am trying to reproduce the results of the paper "Ramos-Méndez J, et al. TOPAS-nBio validation for simulating water radiolysis and DNA damage under low-LET irradiation. Phys Med Biol. 2021" using the provided "IRTDamageToDNAPlasmid" example. This is to validate the model before adapting it to my specific research problem.

I have ran the example with the provided support files and exactly as it is, to obtain the SSB yields. However, I can not find a match between my results and those reported in the paper. I am now confused about this discrepancy. Could someone please clarify which specific graph and data point in the paper I should expect to replicate when running this example?

The following is a part of the output I get from the code:

G4WT0 > =========== Total direct SSB : 0
G4WT0 > =========== Total indirect SSB : 80
G4WT0 > =========== Total dose in envelope : 30.772 Gy
G4WT0 > =========== Total edep in envelope : 0.10056 MeV
G4WT0 > =========== SSB in plasmid /Gy: 2.5998e+24 /Gy
G4WT0 > =========== SSB in plasmid /Gy/Da: 1.9953e+17 /Gy/Da
G4WT0 > =========== SSB in plasmid /100eV: 0.079551 /100 eV
G4WT0 > =========== SSB in plasmid umol/J: 0.0082415 umol/J
G4WT0 > =========== Total events to reach a dose of 30 (Gy) = 834

Thank you in advance for your assistance.
Regards,
Ali

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