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@somethington somethington released this 16 Aug 22:18
· 58 commits to main since this release
v1.0.0-beta
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TPP Solver Beta Release v1.0.0-beta

First release of the beta version of TPP Solver, a tool designed for conducting Thermal Proteome Profiling (TPP) analysis. This application allows researchers to upload intensity data from FragPipe along with metadata in CSV format, enabling analysis of protein thermal stability.

Key Features:

  • Data Upload & Management: Upload FragPipe combined_prot TSV and metadata CSV files.
  • Interactive Data Visualization: View and edit protein data with a user-friendly interface.
  • Curve Fitting & Analysis: Performs sigmoidal curve fitting based on intensity of Max LFQ
  • Data Imputation: Handles missing data points with imputation
  • Downloadable Results: Download fitted curves in SVG format and summary table as CSV

Known Issues & Limitations:

  • Performance: Possible delays with large datasets
  • Compatibility: Currently tested with FragPipe output and specific CSV formats

Installation

Docker image: ghcr.io/username/tpp_solver:v1.0.0-beta

You can pull the image using:

docker pull ghcr.io/username/tpp_solver:v1.0.0-beta

Feedback & Contributions:

We encourage the community to test the app extensively and provide feedback. Please report any bugs, issues, or suggestions through the GitHub Issues tab.

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