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GenomicRegion.cpp
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GenomicRegion.cpp
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/*
* Part of SMITHLAB software
*
* Copyright (C) 2011 University of Southern California and
* Andrew D. Smith
*
* Authors: Andrew D. Smith
*
* This program is free software: you can redistribute it and/or modify
* it under the terms of the GNU General Public License as published by
* the Free Software Foundation, either version 3 of the License, or
* (at your option) any later version.
*
* This program is distributed in the hope that it will be useful,
* but WITHOUT ANY WARRANTY; without even the implied warranty of
* MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
* GNU General Public License for more details.
*
* You should have received a copy of the GNU General Public License
* along with this program. If not, see <http://www.gnu.org/licenses/>.
*/
#include "GenomicRegion.hpp"
#include <exception>
#include <cassert>
#include <fstream>
#include <unordered_map>
using std::ostringstream;
using std::runtime_error;
using std::string;
using std::unordered_map;
using std::vector;
unordered_map<string, chrom_id_type> SimpleGenomicRegion::fw_table_in;
unordered_map<chrom_id_type, string> SimpleGenomicRegion::fw_table_out;
chrom_id_type SimpleGenomicRegion::assign_chrom(const std::string &c) {
auto chr_id(fw_table_in.find(c));
if (chr_id == fw_table_in.end()) {
const chrom_id_type r = fw_table_in.size();
fw_table_in[c] = r;
fw_table_out[r] = c;
// return r;
}
// else return chr_id->second;
return fw_table_in[c];
}
string SimpleGenomicRegion::retrieve_chrom(chrom_id_type i) {
auto chr_name(fw_table_out.find(i));
// assert(chr_name != fw_table_out.end());
return chr_name->second;
}
SimpleGenomicRegion::SimpleGenomicRegion(const GenomicRegion &r)
: chrom(assign_chrom(r.get_chrom())), start(r.get_start()),
end(r.get_end()) {}
SimpleGenomicRegion::SimpleGenomicRegion(const char *s, const size_t len) {
size_t i = 0;
// the chrom
while (isspace(s[i]) && i < len)
++i;
size_t j = i;
while (!isspace(s[i]) && i < len)
++i;
chrom = assign_chrom(string(s + j, i - j));
// start of the region (a positive integer)
while (isspace(s[i]) && i < len)
++i;
j = i;
while (!isspace(s[i]) && i < len)
++i;
start = atoi(s + j);
// end of the region (a positive integer)
while (isspace(s[i]) && i < len)
++i;
j = i;
while (!isspace(s[i]) && i < len)
++i;
end = atoi(s + j);
}
string SimpleGenomicRegion::tostring() const {
std::ostringstream s;
s << retrieve_chrom(chrom) << "\t" << start << "\t" << end;
return s.str();
}
bool SimpleGenomicRegion::contains(const SimpleGenomicRegion &other) const {
return chrom == other.chrom && start <= other.start && other.end <= end;
}
bool SimpleGenomicRegion::overlaps(const SimpleGenomicRegion &other) const {
return chrom == other.chrom &&
((start < other.end && other.end <= end) ||
(start <= other.start && other.start < end) || other.contains(*this));
}
size_t SimpleGenomicRegion::distance(const SimpleGenomicRegion &other) const {
if (chrom != other.chrom)
return std::numeric_limits<size_t>::max();
else if (overlaps(other) || other.overlaps(*this))
return 0;
else
return (end < other.start) ? other.start - end + 1 : start - other.end + 1;
}
bool SimpleGenomicRegion::operator<(const SimpleGenomicRegion &rhs) const {
return (get_chrom() < rhs.get_chrom() ||
(chrom == rhs.chrom &&
(start < rhs.start || (start == rhs.start && (end < rhs.end)))));
}
bool SimpleGenomicRegion::less1(const SimpleGenomicRegion &rhs) const {
return (get_chrom() < rhs.get_chrom() ||
(chrom == rhs.chrom &&
(end < rhs.end || (end == rhs.end && start < rhs.start))));
}
bool SimpleGenomicRegion::operator<=(const SimpleGenomicRegion &rhs) const {
return !(rhs < *this);
}
bool SimpleGenomicRegion::operator==(const SimpleGenomicRegion &rhs) const {
return (chrom == rhs.chrom && start == rhs.start && end == rhs.end);
}
bool SimpleGenomicRegion::operator!=(const SimpleGenomicRegion &rhs) const {
return (chrom != rhs.chrom || start != rhs.start || end != rhs.end);
}
#include <iostream>
unordered_map<string, chrom_id_type> GenomicRegion::fw_table_in;
unordered_map<chrom_id_type, string> GenomicRegion::fw_table_out;
chrom_id_type GenomicRegion::assign_chrom(const std::string &c) {
auto chr_id(fw_table_in.find(c));
if (chr_id == fw_table_in.end()) {
const chrom_id_type r = fw_table_in.size();
fw_table_in[c] = r;
fw_table_out[r] = c;
return r;
}
else
return chr_id->second;
}
string GenomicRegion::retrieve_chrom(chrom_id_type i) {
unordered_map<chrom_id_type, string>::const_iterator chr_name(
fw_table_out.find(i));
assert(chr_name != fw_table_out.end());
return chr_name->second;
}
GenomicRegion::GenomicRegion(const char *s, const size_t len) {
size_t i = 0;
// the chrom
while (isspace(s[i]) && i < len)
++i;
if (i == len)
throw runtime_error(
"malformatted BED file contains only one"
"column in the line below "
"(a properly formatted BED file must contain at least three):\n" +
string(s));
size_t j = i;
while (!isspace(s[i]) && i < len)
++i;
if (i == len)
throw runtime_error(
"malformatted BED file contains only two "
"columns in the line below "
"(a properly formatted BED file must contain at least three):\n" +
string(s));
chrom = assign_chrom(string(s + j, i - j));
// start of the region (a positive integer)
while (isspace(s[i]) && i < len)
++i;
j = i;
start = atoi(s + j);
while (!isspace(s[i]) && i < len)
++i;
// end of the region (a positive integer)
while (isspace(s[i]) && i < len)
++i;
j = i;
end = atoi(s + j);
while (!isspace(s[i]) && i < len)
++i;
// name of the region
while (isspace(s[i]) && i < len)
++i;
j = i;
while (!isspace(s[i]) && i < len)
++i;
name = string(s + j, i - j);
// score of the region (floating point)
while (isspace(s[i]) && i < len)
++i;
j = i;
score = atof(s + j);
while (!isspace(s[i]) && i < len)
++i;
// strand
while (isspace(s[i]) && i < len)
++i;
j = i;
strand = *(s + j);
while (!isspace(s[i]) && i < len)
++i;
// ADS: This is a hack!!!
if (strand != '-')
strand = '+';
}
string GenomicRegion::tostring() const {
std::ostringstream s;
s << retrieve_chrom(chrom) << "\t" << start << "\t" << end;
if (!name.empty())
s << "\t" << name << "\t" << score << "\t" << strand;
return s.str();
}
bool GenomicRegion::contains(const GenomicRegion &other) const {
return chrom == other.chrom && start <= other.start && other.end <= end;
}
bool GenomicRegion::overlaps(const GenomicRegion &other) const {
return chrom == other.chrom &&
((start < other.end && other.end <= end) ||
(start <= other.start && other.start < end) || other.contains(*this));
}
size_t GenomicRegion::distance(const GenomicRegion &other) const {
if (chrom != other.chrom)
return std::numeric_limits<size_t>::max();
else if (overlaps(other) || other.overlaps(*this))
return 0;
else
return (end < other.start) ? other.start - end + 1 : start - other.end + 1;
}
bool GenomicRegion::operator<(const GenomicRegion &rhs) const {
return ((chrom == rhs.chrom &&
(start < rhs.start ||
(start == rhs.start &&
(end < rhs.end || (end == rhs.end &&
(strand < rhs.strand
// || (strand == rhs.strand && name < rhs.name)
)))))) ||
get_chrom() < rhs.get_chrom());
}
bool GenomicRegion::less1(const GenomicRegion &rhs) const {
return ((chrom == rhs.chrom &&
(end < rhs.end || (end == rhs.end &&
(start < rhs.start ||
(start == rhs.start &&
(strand < rhs.strand
// || (strand == rhs.strand && name < rhs.name)
)))))) ||
get_chrom() < rhs.get_chrom());
}
bool GenomicRegion::operator<=(const GenomicRegion &rhs) const {
return !(rhs < *this);
}
bool GenomicRegion::operator==(const GenomicRegion &rhs) const {
return (chrom == rhs.chrom && start == rhs.start && end == rhs.end &&
name == rhs.name && score == rhs.score && strand == rhs.strand);
}
bool GenomicRegion::operator!=(const GenomicRegion &rhs) const {
return (chrom != rhs.chrom || start != rhs.start || end != rhs.end ||
name != rhs.name || score != rhs.score || strand != rhs.strand);
}
void separate_chromosomes(
const vector<SimpleGenomicRegion> ®ions,
vector<vector<SimpleGenomicRegion>> &separated_by_chrom) {
typedef unordered_map<chrom_id_type, vector<SimpleGenomicRegion>> Separator;
Separator separator;
for (vector<SimpleGenomicRegion>::const_iterator i = regions.begin();
i != regions.end(); ++i) {
const chrom_id_type the_chrom(i->chrom);
if (separator.find(the_chrom) == separator.end())
separator[the_chrom] = vector<SimpleGenomicRegion>();
separator[the_chrom].push_back(*i);
}
separated_by_chrom.clear();
for (Separator::iterator i = separator.begin(); i != separator.end(); ++i)
separated_by_chrom.push_back(i->second);
}
void separate_chromosomes(const vector<GenomicRegion> ®ions,
vector<vector<GenomicRegion>> &separated_by_chrom) {
typedef unordered_map<chrom_id_type, vector<GenomicRegion>> Separator;
Separator separator;
for (vector<GenomicRegion>::const_iterator i = regions.begin();
i != regions.end(); ++i) {
const chrom_id_type the_chrom(i->chrom);
if (separator.find(the_chrom) == separator.end())
separator[the_chrom] = vector<GenomicRegion>();
separator[the_chrom].push_back(*i);
}
separated_by_chrom.clear();
for (Separator::iterator i = separator.begin(); i != separator.end(); ++i)
separated_by_chrom.push_back(i->second);
}
static inline auto is_header_line(const string &line) -> bool {
static constexpr auto browser_label = "browser";
static constexpr auto browser_label_len = 7u;
for (auto i = 0u; i < browser_label_len; ++i)
if (line[i] != browser_label[i])
return false;
return true;
}
static inline auto is_track_line(const string &line) -> bool {
static constexpr auto track_label = "track";
static constexpr auto track_label_len = 5u;
for (auto i = 0u; i < track_label_len; ++i)
if (line[i] != track_label[i])
return false;
return true;
}
void ReadBEDFile(const string &filename, vector<GenomicRegion> &the_regions) {
std::ifstream in(filename);
if (!in)
throw runtime_error("failed to open file " + filename);
string line;
while (getline(in, line))
if (!is_header_line(line) && !is_track_line(line))
the_regions.push_back(GenomicRegion(line));
}
void ReadBEDFile(const string &filename,
vector<SimpleGenomicRegion> &the_regions) {
std::ifstream in(filename);
if (isdir(filename.c_str()))
throw runtime_error("BED file is a directory: " + filename);
if (!in.good())
throw runtime_error("cannot open input file " + filename);
string line;
while (getline(in, line))
if (!is_header_line(line) && !is_track_line(line))
the_regions.push_back(SimpleGenomicRegion(line));
}