diff --git a/Lib/test/test_clinic.py b/Lib/test/test_clinic.py
index a7ba7f3d99860e..e210103a80f399 100644
--- a/Lib/test/test_clinic.py
+++ b/Lib/test/test_clinic.py
@@ -731,6 +731,16 @@ def test_cloned_forced_text_signature_illegal(self):
         err = "Cannot use @text_signature when cloning a function"
         self.expect_failure(block, err, lineno=11)
 
+    def test_ignore_preprocessor_in_comments(self):
+        for dsl in "clinic", "python":
+            raw = dedent(f"""\
+                /*[{dsl} input]
+                # CPP directives, valid or not, should be ignored in C comments.
+                #
+                [{dsl} start generated code]*/
+            """)
+            self.clinic.parse(raw)
+
 
 class ParseFileUnitTest(TestCase):
     def expect_parsing_failure(
diff --git a/Misc/NEWS.d/next/Tools-Demos/2025-01-03-23-51-07.gh-issue-128152.IhzElS.rst b/Misc/NEWS.d/next/Tools-Demos/2025-01-03-23-51-07.gh-issue-128152.IhzElS.rst
new file mode 100644
index 00000000000000..9657e138e9911b
--- /dev/null
+++ b/Misc/NEWS.d/next/Tools-Demos/2025-01-03-23-51-07.gh-issue-128152.IhzElS.rst
@@ -0,0 +1,2 @@
+Fix a bug where Argument Clinic's C pre-processor parser tried to parse
+pre-processor directives inside C comments. Patch by Erlend Aasland.
diff --git a/Tools/clinic/libclinic/cpp.py b/Tools/clinic/libclinic/cpp.py
index e115d65a88e1b6..3cfe99b712641d 100644
--- a/Tools/clinic/libclinic/cpp.py
+++ b/Tools/clinic/libclinic/cpp.py
@@ -132,6 +132,9 @@ def pop_stack() -> TokenAndCondition:
         if line_comment:
             line = before.rstrip()
 
+        if self.in_comment:
+            return
+
         if not line.startswith('#'):
             return