diff --git a/newsfragments/2971.removal.rst b/newsfragments/2971.removal.rst
new file mode 100644
index 0000000000..940453ab0a
--- /dev/null
+++ b/newsfragments/2971.removal.rst
@@ -0,0 +1 @@
+Removed upload_docs command.
\ No newline at end of file
diff --git a/setuptools/command/register.py b/setuptools/command/register.py
deleted file mode 100644
index 93ef04aa0e..0000000000
--- a/setuptools/command/register.py
+++ /dev/null
@@ -1,22 +0,0 @@
-from setuptools.errors import RemovedCommandError
-
-from ..dist import Distribution
-
-import distutils.command.register as orig
-from distutils import log
-
-
-class register(orig.register):
-    """Formerly used to register packages on PyPI."""
-
-    distribution: Distribution  # override distutils.dist.Distribution with setuptools.dist.Distribution
-
-    def run(self):
-        msg = (
-            "The register command has been removed, use twine to upload "
-            "instead (https://pypi.org/p/twine)"
-        )
-
-        self.announce("ERROR: " + msg, log.ERROR)
-
-        raise RemovedCommandError(msg)
diff --git a/setuptools/command/upload.py b/setuptools/command/upload.py
deleted file mode 100644
index 649b41fa30..0000000000
--- a/setuptools/command/upload.py
+++ /dev/null
@@ -1,20 +0,0 @@
-from setuptools.dist import Distribution
-from setuptools.errors import RemovedCommandError
-
-from distutils import log
-from distutils.command import upload as orig
-
-
-class upload(orig.upload):
-    """Formerly used to upload packages to PyPI."""
-
-    distribution: Distribution  # override distutils.dist.Distribution with setuptools.dist.Distribution
-
-    def run(self):
-        msg = (
-            "The upload command has been removed, use twine to upload "
-            "instead (https://pypi.org/p/twine)"
-        )
-
-        self.announce("ERROR: " + msg, log.ERROR)
-        raise RemovedCommandError(msg)
diff --git a/setuptools/command/upload_docs.py b/setuptools/command/upload_docs.py
deleted file mode 100644
index 3c2946cfc8..0000000000
--- a/setuptools/command/upload_docs.py
+++ /dev/null
@@ -1,221 +0,0 @@
-"""upload_docs
-
-Implements a Distutils 'upload_docs' subcommand (upload documentation to
-sites other than PyPi such as devpi).
-"""
-
-import functools
-import http.client
-import itertools
-import os
-import shutil
-import tempfile
-import urllib.parse
-import zipfile
-from base64 import standard_b64encode
-
-from .._importlib import metadata
-from ..warnings import SetuptoolsDeprecationWarning
-from .upload import upload
-
-from distutils import log
-from distutils.errors import DistutilsOptionError
-
-
-def _encode(s):
-    return s.encode('utf-8', 'surrogateescape')
-
-
-class upload_docs(upload):
-    # override the default repository as upload_docs isn't
-    # supported by Warehouse (and won't be).
-    DEFAULT_REPOSITORY = 'https://pypi.python.org/pypi/'
-
-    description = 'Upload documentation to sites other than PyPi such as devpi'
-
-    user_options = [
-        (
-            'repository=',
-            'r',
-            "url of repository [default: %s]" % upload.DEFAULT_REPOSITORY,
-        ),
-        ('show-response', None, 'display full response text from server'),
-        ('upload-dir=', None, 'directory to upload'),
-    ]
-    boolean_options = upload.boolean_options
-
-    def has_sphinx(self):
-        return bool(
-            self.upload_dir is None
-            and metadata.entry_points(group='distutils.commands', name='build_sphinx')
-        )
-
-    sub_commands = [('build_sphinx', has_sphinx)]
-
-    def initialize_options(self):
-        upload.initialize_options(self)
-        self.upload_dir = None
-        self.target_dir = None
-
-    def finalize_options(self):
-        log.warn(
-            "Upload_docs command is deprecated. Use Read the Docs "
-            "(https://readthedocs.org) instead."
-        )
-        upload.finalize_options(self)
-        if self.upload_dir is None:
-            if self.has_sphinx():
-                build_sphinx = self.get_finalized_command('build_sphinx')
-                self.target_dir = dict(build_sphinx.builder_target_dirs)['html']
-            else:
-                build = self.get_finalized_command('build')
-                self.target_dir = os.path.join(build.build_base, 'docs')
-        else:
-            self.ensure_dirname('upload_dir')
-            self.target_dir = self.upload_dir
-        self.announce('Using upload directory %s' % self.target_dir)
-
-    def create_zipfile(self, filename):
-        zip_file = zipfile.ZipFile(filename, "w")
-        try:
-            self.mkpath(self.target_dir)  # just in case
-            for root, dirs, files in os.walk(self.target_dir):
-                if root == self.target_dir and not files:
-                    tmpl = "no files found in upload directory '%s'"
-                    raise DistutilsOptionError(tmpl % self.target_dir)
-                for name in files:
-                    full = os.path.join(root, name)
-                    relative = root[len(self.target_dir) :].lstrip(os.path.sep)
-                    dest = os.path.join(relative, name)
-                    zip_file.write(full, dest)
-        finally:
-            zip_file.close()
-
-    def run(self):
-        SetuptoolsDeprecationWarning.emit(
-            "Deprecated command",
-            """
-            upload_docs is deprecated and will be removed in a future version.
-            Instead, use tools like devpi and Read the Docs; or lower level tools like
-            httpie and curl to interact directly with your hosting service API.
-            """,
-            due_date=(2023, 9, 26),  # warning introduced in 27 Jul 2022
-        )
-
-        # Run sub commands
-        for cmd_name in self.get_sub_commands():
-            self.run_command(cmd_name)
-
-        tmp_dir = tempfile.mkdtemp()
-        name = self.distribution.metadata.get_name()
-        zip_file = os.path.join(tmp_dir, "%s.zip" % name)
-        try:
-            self.create_zipfile(zip_file)
-            self.upload_file(zip_file)
-        finally:
-            shutil.rmtree(tmp_dir)
-
-    @staticmethod
-    def _build_part(item, sep_boundary):
-        key, values = item
-        title = '\nContent-Disposition: form-data; name="%s"' % key
-        # handle multiple entries for the same name
-        if not isinstance(values, list):
-            values = [values]
-        for value in values:
-            if isinstance(value, tuple):
-                title += '; filename="%s"' % value[0]
-                value = value[1]
-            else:
-                value = _encode(value)
-            yield sep_boundary
-            yield _encode(title)
-            yield b"\n\n"
-            yield value
-            if value and value[-1:] == b'\r':
-                yield b'\n'  # write an extra newline (lurve Macs)
-
-    @classmethod
-    def _build_multipart(cls, data):
-        """
-        Build up the MIME payload for the POST data
-        """
-        boundary = '--------------GHSKFJDLGDS7543FJKLFHRE75642756743254'
-        sep_boundary = b'\n--' + boundary.encode('ascii')
-        end_boundary = sep_boundary + b'--'
-        end_items = (
-            end_boundary,
-            b"\n",
-        )
-        builder = functools.partial(
-            cls._build_part,
-            sep_boundary=sep_boundary,
-        )
-        part_groups = map(builder, data.items())
-        parts = itertools.chain.from_iterable(part_groups)
-        body_items = itertools.chain(parts, end_items)
-        content_type = 'multipart/form-data; boundary=%s' % boundary
-        return b''.join(body_items), content_type
-
-    def upload_file(self, filename):
-        with open(filename, 'rb') as f:
-            content = f.read()
-        meta = self.distribution.metadata
-        data = {
-            ':action': 'doc_upload',
-            'name': meta.get_name(),
-            'content': (os.path.basename(filename), content),
-        }
-        # set up the authentication
-        credentials = _encode(self.username + ':' + self.password)
-        credentials = standard_b64encode(credentials).decode('ascii')
-        auth = "Basic " + credentials
-
-        body, ct = self._build_multipart(data)
-
-        msg = "Submitting documentation to %s" % (self.repository)
-        self.announce(msg, log.INFO)
-
-        # build the Request
-        # We can't use urllib2 since we need to send the Basic
-        # auth right with the first request
-        schema, netloc, url, params, query, fragments = urllib.parse.urlparse(
-            self.repository
-        )
-        assert not params and not query and not fragments
-        if schema == 'http':
-            conn = http.client.HTTPConnection(netloc)
-        elif schema == 'https':
-            conn = http.client.HTTPSConnection(netloc)
-        else:
-            raise AssertionError("unsupported schema " + schema)
-
-        data = ''
-        try:
-            conn.connect()
-            conn.putrequest("POST", url)
-            content_type = ct
-            conn.putheader('Content-type', content_type)
-            conn.putheader('Content-length', str(len(body)))
-            conn.putheader('Authorization', auth)
-            conn.endheaders()
-            conn.send(body)
-        except OSError as e:
-            self.announce(str(e), log.ERROR)
-            return
-
-        r = conn.getresponse()
-        if r.status == 200:
-            msg = 'Server response (%s): %s' % (r.status, r.reason)
-            self.announce(msg, log.INFO)
-        elif r.status == 301:
-            location = r.getheader('Location')
-            if location is None:
-                location = 'https://pythonhosted.org/%s/' % meta.get_name()
-            msg = 'Upload successful. Visit %s' % location
-            self.announce(msg, log.INFO)
-        else:
-            msg = 'Upload failed (%s): %s' % (r.status, r.reason)
-            self.announce(msg, log.ERROR)
-        if self.show_response:
-            print('-' * 75, r.read(), '-' * 75)
diff --git a/setuptools/tests/test_register.py b/setuptools/tests/test_register.py
deleted file mode 100644
index 0c7d109d31..0000000000
--- a/setuptools/tests/test_register.py
+++ /dev/null
@@ -1,19 +0,0 @@
-from unittest import mock
-
-import pytest
-
-from setuptools.command.register import register
-from setuptools.dist import Distribution
-from setuptools.errors import RemovedCommandError
-
-
-class TestRegister:
-    def test_register_exception(self):
-        """Ensure that the register command has been properly removed."""
-        dist = Distribution()
-        dist.dist_files = [(mock.Mock(), mock.Mock(), mock.Mock())]
-
-        cmd = register(dist)
-
-        with pytest.raises(RemovedCommandError):
-            cmd.run()
diff --git a/setuptools/tests/test_upload.py b/setuptools/tests/test_upload.py
deleted file mode 100644
index cbcd455c41..0000000000
--- a/setuptools/tests/test_upload.py
+++ /dev/null
@@ -1,19 +0,0 @@
-from unittest import mock
-
-import pytest
-
-from setuptools.command.upload import upload
-from setuptools.dist import Distribution
-from setuptools.errors import RemovedCommandError
-
-
-class TestUpload:
-    def test_upload_exception(self):
-        """Ensure that the register command has been properly removed."""
-        dist = Distribution()
-        dist.dist_files = [(mock.Mock(), mock.Mock(), mock.Mock())]
-
-        cmd = upload(dist)
-
-        with pytest.raises(RemovedCommandError):
-            cmd.run()