From e57aa53d3c4598272f71d6de43908c5e77a1cace Mon Sep 17 00:00:00 2001 From: Mingye Wang Date: Sat, 18 Jan 2025 16:42:13 +0800 Subject: [PATCH] =?UTF-8?q?=E9=86=8B=E9=85=B8=E7=94=B2=E7=BE=9F=E5=AD=95?= =?UTF-8?q?=E9=85=AE=EF=BC=9A=E9=9D=92=E6=98=A5=E6=9C=9F=E6=8A=91=E5=88=B6?= =?UTF-8?q?=E7=94=A8?= MIME-Version: 1.0 Content-Type: text/plain; charset=UTF-8 Content-Transfer-Encoding: 8bit Signed-off-by: Mingye Wang --- .../docs/medicine/antiandrogen/medroxyprogesterone/index.md | 6 +++++- 1 file changed, 5 insertions(+), 1 deletion(-) diff --git a/content/zh-cn/docs/medicine/antiandrogen/medroxyprogesterone/index.md b/content/zh-cn/docs/medicine/antiandrogen/medroxyprogesterone/index.md index 07931603a4..0dd0de5873 100644 --- a/content/zh-cn/docs/medicine/antiandrogen/medroxyprogesterone/index.md +++ b/content/zh-cn/docs/medicine/antiandrogen/medroxyprogesterone/index.md @@ -10,6 +10,8 @@ description: 醋酸甲羟孕酮（Medroxyprogesterone Acetate），是一种类 醋酸甲羟孕酮（Medroxyprogesterone Acetate, MPA），是一种类固醇孕激素，具有抗促性腺激素作用，可以抑制体内雄激素水平。[^1] 在无法获取到 [醋酸环丙孕酮（色谱龙）]({{< ref cyproterone >}}) 时可作为替代品服用，但效果稍差。[^2] [^3] [^11] 关于 MPA 对睾酮水平的抑制作用，可参考[下文]({{< ref "#testosterone-suppression" >}})。 +除作为 MtF HRT 的一部分抑制雄激素水平外，也可用于未成年人的青春期阻断治疗，相比 GnRH 类似物价格更低廉。[^14]旧时也用于治疗早发育，但由于不能抑制早发育对骨的影响，现已被 GnRH 类似物替代。[^15]用于青春期阻断无此考虑。 + > **大中华区上市状况** ```csv @@ -86,4 +88,6 @@ description: 醋酸甲羟孕酮（Medroxyprogesterone Acetate），是一种类 [^10]: 嘉義基督教醫院. 藥品詳細資訊：Medrone 5mg Tablets [EB/OL]. \[[資訊頁](https://www.cych.org.tw/pharm/searchdrugdetail.aspx?drug_serial=9622)] \[[仿單](https://www.cych.org.tw/pharm/%e4%bb%bf%e5%96%ae/PROVE-1080726.pdf)] [^11]: Aly. An Introduction to Hormone Therapy for Transfeminine People [EB/OL]. *Transfeminine Science*, 2018. 译文：《[女性倾向跨性别者的激素治疗简介](https://tfsci.mtf.wiki/articles/transfem-intro/)》 [^12]: Meyer W J, Walker P A, Emory L E, et al. Physical, metabolic, and hormonal effects on men of long-term therapy with medroxyprogesterone acetate [J]. *Fertility and Sterility*, 1985, 43(1): 102-109. DOI: [10.1016/S0015-0282(16)48326-3](https://www.sciencedirect.com/science/article/pii/S0015028216483263) -[^13]: Pfizer. Prescribing Information: PROVERA® [EB/OL]. Drugs@FDA, 2024. 【[译文](https://tfsci.mtf.wiki/misc/provera/)】 \ No newline at end of file +[^13]: Pfizer. Prescribing Information: PROVERA® [EB/OL]. Drugs@FDA, 2024. 【[译文](https://tfsci.mtf.wiki/misc/provera/)】 +[^14]: Jain J, Kwan D, Forcier M. Medroxyprogesterone Acetate in Gender-Affirming Therapy for Transwomen: Results From a Retrospective Study. J Clin Endocrinol Metab. 2019 Nov 1;104(11):5148-5156. doi: [10.1210/jc.2018-02253](https://academic.oup.com/jcem/article/104/11/5148/5479358). PMID: 31127826. +[^15]: Wheeler MD, Styne DM. Diagnosis and management of precocious puberty. Pediatr Clin North Am. 1990 Dec;37(6):1255-71. doi: 10.1016/s0031-3955(16)37010-9. PMID: 2147987.