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DESCRIPTION
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DESCRIPTION
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Type: Package
Package: mmrm
Title: Mixed Models for Repeated Measures
Version: 0.3.14.9001
Authors@R: c(
person("Daniel", "Sabanes Bove", , "daniel.sabanes_bove@rconis.com", role = c("aut", "cre"),
comment = c(ORCID = "0000-0002-0176-9239")),
person("Liming", "Li", , "liming.li@roche.com", role = "aut"),
person("Julia", "Dedic", , "julia.dedic@roche.com", role = "aut"),
person("Doug", "Kelkhoff", , "doug.kelkhoff@roche.com", role = "aut"),
person("Kevin", "Kunzmann", , "kevin.kunzmann@boehringer-ingelheim.com", role = "aut"),
person("Brian Matthew", "Lang", , "brian.lang@msd.com", role = "aut"),
person("Christian", "Stock", , "christian.stock@boehringer-ingelheim.com", role = "aut"),
person("Ya", "Wang", , "ya.wang10@gilead.com", role = "aut"),
person("Craig", "Gower-Page", , "craig.gower-page@roche.com", role = "ctb"),
person("Dan", "James", , "dan.james@astrazeneca.com", role = "aut"),
person("Jonathan", "Sidi", , "yoni@pinpointstrategies.io", role = "aut"),
person("Daniel", "Leibovitz", , "daniel.leibovitz@roche.com", role = "aut"),
person("Daniel D.", "Sjoberg", , "sjobergd@gene.com", role = "aut",
comment = c(ORCID = "0000-0003-0862-2018")),
person("Lukas A.", "Widmer", role = "ctb",
comment = c(ORCID = "0000-0003-1471-3493")),
person("Boehringer Ingelheim Ltd.", role = c("cph", "fnd")),
person("Gilead Sciences, Inc.", role = c("cph", "fnd")),
person("F. Hoffmann-La Roche AG", role = c("cph", "fnd")),
person("Merck Sharp & Dohme, Inc.", role = c("cph", "fnd")),
person("AstraZeneca plc", role = c("cph", "fnd")),
person("inferential.biostatistics GmbH", role = c("cph", "fnd"))
)
Description: Mixed models for repeated measures (MMRM) are a popular
choice for analyzing longitudinal continuous outcomes in randomized
clinical trials and beyond; see Cnaan, Laird and Slasor (1997)
<doi:10.1002/(SICI)1097-0258(19971030)16:20%3C2349::AID-SIM667%3E3.0.CO;2-E>
for a tutorial and Mallinckrodt, Lane, Schnell, Peng and Mancuso
(2008) <doi:10.1177/009286150804200402> for a review. This package
implements MMRM based on the marginal linear model without random
effects using Template Model Builder ('TMB') which enables fast and
robust model fitting. Users can specify a variety of covariance
matrices, weight observations, fit models with restricted or standard
maximum likelihood inference, perform hypothesis testing with
Satterthwaite or Kenward-Roger adjustment, and extract least square
means estimates by using 'emmeans'.
License: Apache License 2.0
URL: https://openpharma.github.io/mmrm/
BugReports: https://github.com/openpharma/mmrm/issues
Depends:
R (>= 4.0)
Imports:
checkmate (>= 2.0),
generics,
lifecycle,
Matrix,
methods,
nlme,
parallel,
Rcpp,
Rdpack,
stats,
stringr,
tibble,
TMB (>= 1.9.1),
utils
Suggests:
broom.helpers,
car (>= 3.1.2),
cli,
clubSandwich,
clusterGeneration,
dplyr,
emmeans (>= 1.6),
estimability,
ggplot2,
glmmTMB,
hardhat,
knitr,
lme4,
MASS,
microbenchmark,
mockery,
parallelly (>= 1.32.0),
parsnip (>= 1.1.0),
purrr,
rmarkdown,
sasr,
scales,
testthat (>= 3.0.0),
tidymodels,
withr,
xml2
LinkingTo:
Rcpp,
RcppEigen,
testthat,
TMB (>= 1.9.1)
VignetteBuilder:
knitr
RdMacros:
Rdpack
Config/testthat/edition: 3
Encoding: UTF-8
Language: en-US
LazyData: true
NeedsCompilation: yes
Roxygen: list(markdown = TRUE)
RoxygenNote: 7.3.2
Collate:
'between-within.R'
'catch-routine-registration.R'
'component.R'
'cov_struct.R'
'data.R'
'empirical.R'
'fit.R'
'kenwardroger.R'
'mmrm-methods.R'
'mmrm-package.R'
'utils.R'
'residual.R'
'utils-nse.R'
'utils-formula.R'
'satterthwaite.R'
'skipping.R'
'tidiers.R'
'testing.R'
'tmb-methods.R'
'tmb.R'
'interop-emmeans.R'
'interop-parsnip.R'
'interop-car.R'
'zzz.R'