From 0f54c3c2549260893948ccd7c9c20331022bcd51 Mon Sep 17 00:00:00 2001 From: Ilya Flyamer Date: Thu, 10 Jan 2019 12:27:29 +0000 Subject: [PATCH] Update README.md Add schematic and a short explanation --- README.md | 5 +++++ 1 file changed, 5 insertions(+) diff --git a/README.md b/README.md index d35874a..4958252 100644 --- a/README.md +++ b/README.md @@ -7,6 +7,11 @@ A versatile tool to perform pile-up analysis on Hi-C data in .cool format (https `pip install coolpuppy` will make coolpup.py callable in your terminal. +This is the idea of how pileups work, in case you are checking whether certain regions tend to interacts with each other: + + + +What's not shown here is normalization to the expected values, done here by dividing the pileups by randomly shifted control regions. In the future dividing by expected values from whole-chromosome by-diagonal average will be possible. ``` Usage: coolpup.py [-h] [--pad PAD] [--minshift MINSHIFT] [--maxshift MAXSHIFT]