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Improve introduction to projects and goals.
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yjcyxky committed Jul 3, 2024
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10 changes: 5 additions & 5 deletions docs/goals.md
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## 📚 Research Tasks

> Auto-immune diseases, such as ME/CFS, Long Covid, ALS, etc.
> Rare and complex diseases, such as ME/CFS, Long Covid, ALS, etc.
### 🧑‍🔬 Curating BioMedical Knowledges and Omics Data

- Curate multi-omics data and knowledge from public databases and literatures for `auto-immune diseases`.
- Curate multi-omics data and knowledge from public databases and literatures for `Rare and complex diseases`.

### 🕸️ Building BioMedical Knowledge Graph

- Build a biomedical knowledge graph for drug repurposing and disease mechanism for `auto-immune diseases`.
- Build a biomedical knowledge graph for drug repurposing and disease mechanism for `Rare and complex diseases`.

> <img alt="Knowledge Graph" src="/assets/images/knowledge-graph.png" width="100%" />
### 🧮 Data Analysis and Modeling

- Analyze multi-omics data for `auto-immune diseases`.
- Train deep learning models to integrate multi-omics data and knowledge graph to predict drugs and understand disease mechanisms for `auto-immune diseases`.
- Analyze multi-omics data for `Rare and complex diseases`.
- Train deep learning models to integrate multi-omics data and knowledge graph to predict drugs and understand disease mechanisms for `Rare and complex diseases`.
13 changes: 9 additions & 4 deletions docs/platform.md
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- navigation
---

## Introduction to Our Platform

<div style="position: relative; width: 100%;
padding-top: calc(100% * 720 / 1280);
border: 2px black solid;">
<iframe src="//player.bilibili.com/player.html?aid=364614495&bvid=BV1S94y187ev&cid=1296306181&p=1" scrolling="no" border="0" frameborder="no" framespacing="0" allowfullscreen="true" style="position: absolute; width: 100%; height: 100%; top: 0;">
</iframe>
</div>

## 🖥️ Open-Source Projects from Our Lab

### Knowledge Curation and Databases
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| Title | Description |
|--|--|
| [Quartet Data Portal](https://www.chinese-quartet.org/#/data/download/quartet-genomics) | A data portal for quality control of multi-omics data. It contains a lot of high quality multi-omics data based on the quartet reference materials. If you want to ensure your data quality, you can use it as a reference. |

### For Auto-Immune Disease

Comming soon.
58 changes: 6 additions & 52 deletions docs/projects.md
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# 📝 Ongoing Research Projects - 2024

## Introduction
## Curation - Building Knowledge Graph for ME/CFS and Long COVID

<div style="position: relative; width: 100%;
padding-top: calc(100% * 720 / 1280);
border: 2px black solid;">
<iframe src="//player.bilibili.com/player.html?aid=364614495&bvid=BV1S94y187ev&cid=1296306181&p=1" scrolling="no" border="0" frameborder="no" framespacing="0" allowfullscreen="true" style="position: absolute; width: 100%; height: 100%; top: 0;">
</iframe>
</div>

## Curation - Building Your Own Knowledge Graph

### 🧑‍🔬 Curation of BioMedical Knowledges for Chemotherapy-induced Thrombocytopenia (CIT)

> Goal: curate latest findings from literatures and build a knowledgebase for Thrombocytopenia. It may complete the knowledge graph for thrombocytopenia.
>
> Category: Knowledge Curation; Database;
> Description:
> Group Members: Zhixing Zhu, Xiuwen Chen, Feng Zhu, Mingming Li
> Publication:
> Website: [Thrombocytopenia Knowledgebase](https://prophet-studio.3steps.cn)
### 🧑‍🔬 Curation of BioMedical Knowledges for ME/CFS and Long COVID

> Goal: curate latest findings from literatures and build a knowledgebase for ME/CFS and Long COVID. These findings include drug targets, disease mechanisms and biomarkers. It may help us to train deep learning models to curate knowledges automatically and be part of the knowledge graph for drug repurposing, disease mechanism and biomarker screening.
> Goal: curate latest findings from literatures and build a knowledgebase for ME/CFS and Long COVID. These findings include drug targets, disease mechanisms and biomarkers. It may help us to train deep learning models to curate knowledges automatically and be part of the knowledge graph for drug repurposing, disease mechanism.
> Category: Knowledge Curation; Database;
> Description:
> Group Members: Yuchen Ye, Yurong Zhao
> Group Members: Yuchen Ye, Jingcheng Yang
> Publication:
> Website: [ME/CFS and Long COVID Knowledgebase](https://prophet-studio.3steps.cn)

## Platform

### 🕸️ Building of BioMedical Knowledge Graph and Graph Neural Network for Drug Repurposing
## AI Model - Building of BioMedical Knowledge Graph and Graph Neural Network for finding existing drugs for ME/CFS and Long COVID

> <img alt="BioMedGPS" src="/assets/images/biomedgps.png" width="100%" />
> Goal: build a common biomedical knowledge graph for drug repurposing, disease mechanism and biomarker screening.
> Goal: build a specialized knowledge graph for ME/CFS and Long COVID, and train a graph neural network model to predict new indications for known drugs through drug repurposing.
> Category: Deep Learning; Online Platform;
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> Publication:
> Repository: [BioMedGPS](https://github.com/yjcyxky/biomedgps)

## Databases

### 🧬 Building of sgRNA database for CRISPR/Cas9

> Goal: curate all sgRNAs from literatures and develop an online database.
> Category: Database; Knowledge Curation
> Description:
> Website: [CRISPR/Cas9 sgRNA Database](https://biosolver.cn)
> Group Members: Fanhao Zhou, Yiming Cai, Zijing Ma, Xiuwen Chen
> Publication:
> Repository: [sgRNA Checker](https://github.com/yjcyxky/sgrna-checker)
> Repository: [BioMedGPS](https://github.com/yjcyxky/biomedgps-data)

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