A bit confused about the documentation for the runtime

[yf-yang]

https://module-federation.io/guide/basic/runtime.html#api

On the top of the example code, there are comments said:

// You can use the runtime to load modules without depending on the build plugin
// When not using the build plugin, shared dependencies cannot be automatically configured

What does it mean exactly?
Suppose a modern.js host app (without using build plugin) specifies shared singleton dependency package SomePackage, when loading remote who also shares SomePackage as a singleton, could it work?