diff --git a/.changeset/weak-jars-tap.md b/.changeset/weak-jars-tap.md
new file mode 100644
index 00000000000..5322d48f086
--- /dev/null
+++ b/.changeset/weak-jars-tap.md
@@ -0,0 +1,5 @@
+---
+'@module-federation/runtime': patch
+---
+
+fix: window.location.origin will be "null" in iframe srcDoc
diff --git a/packages/runtime/src/core.ts b/packages/runtime/src/core.ts
index e5ece7a9f92..27e340a1b4f 100644
--- a/packages/runtime/src/core.ts
+++ b/packages/runtime/src/core.ts
@@ -764,7 +764,7 @@ export class FederationHost {
         }
         // Set the remote entry to a complete path
         if ('entry' in remote) {
-          if (isBrowserEnv()) {
+          if (isBrowserEnv() && !remote.entry.startsWith('http')) {
             remote.entry = new URL(remote.entry, window.location.origin).href;
           }
         }