LEEPO

Liposome Encapsulation Efficiency Predictor & Optimizer

This program was made based on the following research work:

Xu, Xiaoming, Mansoor A. Khan, and Diane J. Burgess. "Predicting hydrophilic drug encapsulation inside unilamellar liposomes." International journal of pharmaceutics 423.2 (2012): 410-418.

DOI : https://doi.org/10.1016/j.ijpharm.2011.12.019

Python code to calculate Encapuslation efficiecny of Liposomes

(L)iposome

(E)ncapsulation

    (E)fficiency
    
        (P)redictor &
        
            (O)ptimizer

Program Usage : python LEEPO.py mu sigma, sizerange ...

Example command : python LEEPO.py 190.0 38.0 1000 0.23 5.2 0.45 140 5 60.04

Enter the system parameters in the order of:

1. Mean (μ - nm {float})
2. Standard deviation (σ - nm {float})
3. Size range (eg: for 1-1000 nm enter "1000")
4. Anticipated defect (% {float})
5. Bilayer thickness (d - nm)
6. Molecular area of lipid (a - nm^2)
7. Lipid molar concentration (c - mMol/L)
8. Total volume (V - ml)
9. Expected Encapsulation efficiency (%) [optional] - provide only if defect value optimization is required.

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