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topic1_analysis.html
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<!DOCTYPE html>
<html>
<head>
<title>Topic 1 Analysis: Arterial Endothelial Development and Metabolism</title>
<style>
body {
font-family: Arial, sans-serif;
line-height: 1.6;
max-width: 1200px;
margin: 0 auto;
padding: 20px;
}
h1, h2, h3 {
color: #2c3e50;
}
.network-container {
width: 100%;
height: 800px;
border: 1px solid #ddd;
margin: 20px 0;
}
code {
background-color: #f7f7f7;
padding: 2px 4px;
border-radius: 3px;
}
</style>
</head>
<body>
<h1>Topic 1 Analysis: Arterial Endothelial Development and Metabolism</h1>
<h2>Overview</h2>
<p>Topic 1 represents a coordinated program of arterial endothelial cell development, angiogenesis, and metabolic regulation. The gene signature suggests active vascular remodeling with strong involvement of Notch and VEGF signaling pathways.</p>
<h2>Interactive Network</h2>
<!-- STRING Network iframe -->
<iframe
src="https://string-db.org/cgi/network?identifier=Dll4%0dNotch1%0dHey1%0dFlt1%0dEsm1%0dAngpt2%0dErg%0dEts1%0dWwtr1%0dPrdm1%0dHopx%0dGja1%0dAlcam%0dEng&species=10090&network_flavor=evidence&required_score=400&hide_disconnected_nodes=1"
style="width:100%; height:800px; border:none;"
allowfullscreen
frameborder="0">
</iframe>
<h2>Key Pathway Components</h2>
<h3>1. Arterial Specification Program</h3>
<h4>Notch Signaling</h4>
<ul>
<li><code>Dll4</code> (Delta-like 4): Key arterial fate determinant</li>
<li><code>Notch1</code>: Arterial specification receptor</li>
<li><code>Hey1</code>: Notch target transcription factor</li>
<li><code>Adam10</code>: Notch pathway protease</li>
</ul>
<h4>VEGF Pathway</h4>
<ul>
<li><code>Flt1</code> (VEGFR1): VEGF receptor</li>
<li><code>Esm1</code>: VEGF-inducible endothelial marker</li>
<li><code>Angpt2</code>: Vascular remodeling factor</li>
<li><code>Flt4</code> (VEGFR3): Lymphatic/venous development</li>
</ul>
<!-- Continue with the rest of the content from the markdown -->
<h2>Functional Implications</h2>
<ol>
<li><strong>Vascular Development</strong>
<ul>
<li>Strong arterial specification program</li>
<li>Active angiogenic signaling</li>
<li>ECM remodeling capacity</li>
</ul>
</li>
<li><strong>Metabolic Adaptation</strong>
<ul>
<li>Enhanced nutrient transport</li>
<li>Active metabolic regulation</li>
<li>Energy metabolism flexibility</li>
</ul>
</li>
</ol>
<h2>Statistical Summary</h2>
<ul>
<li>Total genes analyzed: 300</li>
<li>Key pathway components: ~40% of top genes</li>
<li>Major functional categories:
<ul>
<li>Arterial development: 25%</li>
<li>Metabolism: 20%</li>
<li>Cell signaling: 30%</li>
<li>ECM/Adhesion: 15%</li>
<li>Others: 10%</li>
</ul>
</li>
</ul>
</body>
</html>