diff --git a/.travis.yml b/.travis.yml
index 1c4fc86..c62ab8f 100644
--- a/.travis.yml
+++ b/.travis.yml
@@ -8,39 +8,26 @@ branches:
   only:
     - master
 
-python:
-  - "2.7"
-  #- "pypy"
-
 env:
-  - MODE=inplace
-  - MODE=sdist
-  - MODE=wheel
+  - TOXENV=py27-twlatest
+  - TOXENV=py27-twtrunk
+  - TOXENV=py27-tw14
+  # Test inplace on one variant
+  - TOXENV=py27-twlatest DEVELOP=--develop
+
+matrix:
+  allow_failures:
+    - env: TOXENV=py27-twtrunk
 
 install:
-  # Upgrade pip/setuptools
-  - pip install -U pip setuptools
-  # Tools for checking coverage and uploading to Codecov
-  - pip install coverage codecov
-  - |
-    python setup.py --version
-    if [ "${MODE}" == "inplace" ]; then
-        pip install --editable .
-    elif [ "${MODE}" == "sdist" ]; then
-        python setup.py sdist
-        pip install dist/Mantissa-"$(python setup.py --version)".tar.gz
-    elif [ "${MODE}" == "wheel" ]; then
-        pip install wheel
-        python setup.py bdist_wheel
-        pip install dist/Mantissa-"$(python setup.py --version)"-py2-none-any.whl
-    fi
+  - pip install -U pip setuptools wheel
+  - pip install tox codecov
 
 script:
-  - cd /tmp && coverage run --branch --source=xmantissa $(type -p trial) xmantissa
-  - cd /tmp && coverage report -m
+  - tox ${DEVELOP}
 
 after_success:
-  - cd "${TRAVIS_BUILD_DIR}" && mv /tmp/.coverage . && codecov
+  - mv .tox/.coverage . && codecov
 
 notifications:
   email: false
diff --git a/tox.ini b/tox.ini
new file mode 100644
index 0000000..2f482ce
--- /dev/null
+++ b/tox.ini
@@ -0,0 +1,19 @@
+[tox]
+envlist={py27}-{twtrunk,twlatest,tw14}
+
+[testenv]
+# Remove this once the PyPy branch lands:
+setenv =
+    PYTHONHASHSEED = 0
+changedir={toxworkdir}
+deps=
+    twlatest: Twisted
+    twtrunk: https://github.com/twisted/twisted/archive/trunk.zip
+    tw14: Twisted==14.0.0
+    coverage
+commands=
+    pip list
+    coverage run {envdir}/bin/trial \
+        --temp-directory={envdir}/_trial_temp {posargs:xmantissa}
+    coverage report --rcfile={toxinidir}/.coveragerc
+    coverage html --rcfile={toxinidir}/.coveragerc --directory {envdir}/_coverage