Update README.Md

README.Md

@@ -27,6 +27,11 @@ This function performs all three steps in xCell, which can be performed seperate
 
 xCell loads the xCell.data object wich is a list with the spill over and calibration paramters, the signatures and the list of genes it uses. However, one can use different signautres and different spill over functions to perform the analysis.
 
+In addition xCell provides significance assessment of the null hypothesis that the cell type is not in the mixture:
+
+1. xCellSignifcanceBetaDist - uses predefined beta distribution parameters from random mixtures generated using the reference data sets. Recommended. 
+2. xCellSignifcanceRandomMatrix - uses random maxtrix and caculates beta distribution parameters. 
+
 See documentation for more details on each function.
 
 # Data input
@@ -52,4 +57,4 @@ Regarding this issue, scaling the scores by samples is extremely dangerous and w
 
 xCell is developed by the Butte lab. Please contact Dvir Aran: dvir.aran at ucsf edu for any questions or suggestions.
 
-To cite xCell: Aran, Hu and Butte, xCell: Digitally portraying the tissue cellular heterogeneity landscape. bioRxiv, 2017
+To cite xCell: Aran, Hu and Butte, xCell: Digitally portraying the tissue cellular heterogeneity landscape. bioRxiv, 2017