diff --git a/.flake8 b/.flake8
new file mode 100644
index 0000000..35967ff
--- /dev/null
+++ b/.flake8
@@ -0,0 +1,4 @@
+[flake8]
+ignore = E203, E266, E501, W503, E211, E731
+max-line-length = 88
+select = B,C,E,F,W,T4,B9
diff --git a/.github/workflows/ci-tests.yml b/.github/workflows/ci-tests.yml
index cf34d1d..573fb61 100644
--- a/.github/workflows/ci-tests.yml
+++ b/.github/workflows/ci-tests.yml
@@ -6,6 +6,10 @@ on:
   pull_request:
     branches: [ main ]
 
+concurrency:
+  group: build-${{ github.event.pull_request.number || github.ref }}
+  cancel-in-progress: true
+
 jobs:
 
   tox:
@@ -16,7 +20,7 @@ jobs:
     strategy:
       matrix:
         py-ver-major: [3]
-        py-ver-minor: [6, 7, 8, 9]
+        py-ver-minor: [6, 7, 8, 9, 10]
         step: [lint, unit, mypy]
 
     env:
@@ -54,7 +58,7 @@ jobs:
 
       - name: Upload coverage to Codecov
         if: ${{ matrix.step == 'unit' }}
-        uses: codecov/codecov-action@v1
+        uses: codecov/codecov-action@v2.1.0
         with:
           fail_ci_if_error: true
 
@@ -65,11 +69,11 @@ jobs:
 
     strategy:
       matrix:
-        step: [lint-readme, pydocstyle]
+        step: [lintreadme, pydocstyle]
 
     env:
-      py-semver: 3.9
-      TOXENV: ${{ format('py39-{0}', matrix.step) }}
+      py-semver: "3.10"
+      TOXENV: ${{ format('py310-{0}', matrix.step) }}
 
     steps:
       - uses: actions/checkout@v2
@@ -110,7 +114,7 @@ jobs:
       - name: Set up Python
         uses: actions/setup-python@v2
         with:
-          python-version: 3.9
+          python-version: "3.10"  # quoted, otherwise that turns into the number 3.1
 
       - name: Cache for pip
         uses: actions/cache@v2
diff --git a/MANIFEST.in b/MANIFEST.in
index 6e775fd..74643c8 100644
--- a/MANIFEST.in
+++ b/MANIFEST.in
@@ -1,4 +1,4 @@
-include Makefile gittaggers.py test-requirements.txt mypy_requirements.txt requirements.txt
+include Makefile gittaggers.py test-requirements.txt mypy-requirements.txt requirements.txt
 include cwltest/cwltest-schema.yml
 include cwltest/tests/*
 include cwltest/tests/test-data/*
diff --git a/Makefile b/Makefile
index abda48e..ea7110e 100644
--- a/Makefile
+++ b/Makefile
@@ -28,7 +28,7 @@ PACKAGE=cwltest
 PYSOURCES=$(wildcard ${MODULE}/**.py tests/*.py) setup.py
 DEVPKGS=diff_cover black pylint pep257 pydocstyle flake8 tox tox-pyenv \
 	isort wheel autoflake flake8-bugbear pyupgrade bandit \
-	-rtest-requirements.txt -rmypy_requirements.txt
+	-rtest-requirements.txt -rmypy-requirements.txt
 DEBDEVPKGS=pep8 python-autopep8 pylint python-coverage pydocstyle sloccount \
 	   python-flake8 python-mock shellcheck
 VERSION=2.2.$(shell TZ=UTC git log --first-parent --max-count=1 \
diff --git a/cwltest/utils.py b/cwltest/utils.py
index 984d8a8..50e1cb5 100644
--- a/cwltest/utils.py
+++ b/cwltest/utils.py
@@ -111,7 +111,7 @@ def check_keys(keys, expected, actual):
         except CompareFail as e:
             raise CompareFail.format(
                 expected, actual, f"field '{k}' failed comparison: {str(e)}"
-            )
+            ) from e
 
 
 def compare_file(expected, actual):
@@ -159,7 +159,7 @@ def compare_dict(expected, actual):
         except CompareFail as e:
             raise CompareFail.format(
                 expected, actual, f"failed comparison for key '{c}': {e}"
-            )
+            ) from e
     extra_keys = set(actual.keys()).difference(list(expected.keys()))
     for k in extra_keys:
         if actual[k] is not None:
@@ -194,13 +194,13 @@ def compare(expected, actual):  # type: (Any, Any) -> None
                 try:
                     compare(expected[c], actual[c])
                 except CompareFail as e:
-                    raise CompareFail.format(expected, actual, e)
+                    raise CompareFail.format(expected, actual, e) from e
         else:
             if expected != actual:
                 raise CompareFail.format(expected, actual)
 
     except Exception as e:
-        raise CompareFail(str(e))
+        raise CompareFail(str(e)) from e
 
 
 def get_test_number_by_key(tests, key, value):
diff --git a/mypy_requirements.txt b/mypy-requirements.txt
similarity index 100%
rename from mypy_requirements.txt
rename to mypy-requirements.txt
diff --git a/release-test.sh b/release-test.sh
index dcb6d90..e840392 100755
--- a/release-test.sh
+++ b/release-test.sh
@@ -7,6 +7,8 @@ export LC_ALL=C
 
 package=cwltest
 module=cwltest
+extras=""
+
 if [ "$GITHUB_ACTIONS" = "true" ]; then
     # We are running as a GH Action
     repo=${GITHUB_SERVER_URL}/${GITHUB_REPOSITORY}.git
@@ -16,8 +18,8 @@ else
     HEAD=$(git rev-parse HEAD)
 fi
 run_tests="bin/py.test --pyargs ${module}"
-pipver=20.3b1 # minimum required version of pip for Python 3.9
-setuptoolsver=41.1.0 # required for Python 3.9
+pipver=20.3.3  # minimum required version of pip for Python 3.10
+setuptoolsver=50.0.0  # required for Python 3.10
 DIR="$( cd "$( dirname "${BASH_SOURCE[0]}" )" >/dev/null && pwd )"
 
 rm -Rf testenv? || /bin/true
@@ -33,7 +35,7 @@ then
 	rm -f testenv1/lib/python-wheels/setuptools* \
 		&& pip install --force-reinstall -U pip==${pipver} \
 		&& pip install setuptools==${setuptoolsver} wheel
-	pip install -rtest-requirements.txt
+	pip install -rtest-requirements.txt ".${extras}"
 	make test
 	pip uninstall -y ${package} || true; pip uninstall -y ${package} || true; make install
 	mkdir testenv1/not-${module}
@@ -59,7 +61,7 @@ rm -f lib/python-wheels/setuptools* \
 	&& pip install --force-reinstall -U pip==${pipver} \
         && pip install setuptools==${setuptoolsver} wheel
 # The following can fail if you haven't pushed your commits to ${repo}
-pip install -e "git+${repo}@${HEAD}#egg=${package}"
+pip install -e "git+${repo}@${HEAD}#egg=${package}${extras}"
 pushd src/${package}
 pip install -rtest-requirements.txt
 make dist
@@ -83,13 +85,13 @@ rm -f lib/python-wheels/setuptools* \
         && pip install setuptools==${setuptoolsver} wheel
 package_tar=$(find . -name "${package}*tar.gz")
 pip install "-r${DIR}/test-requirements.txt"
-pip install "${package_tar}"
+pip install "${package_tar}${extras}"
 mkdir out
 tar --extract --directory=out -z -f ${package}*.tar.gz
 pushd out/${package}*
 make dist
 make test
-pip install "-r${DIR}/mypy_requirements.txt"
+pip install "-r${DIR}/mypy-requirements.txt"
 make mypy
 pip uninstall -y ${package} || true; pip uninstall -y ${package} || true; make install
 mkdir ../not-${module}
@@ -107,7 +109,7 @@ source bin/activate
 rm -f lib/python-wheels/setuptools* \
 	&& pip install --force-reinstall -U pip==${pipver} \
         && pip install setuptools==${setuptoolsver} wheel
-pip install ${module}*.whl
+pip install "$(ls ${module}*.whl)${extras}"
 pip install "-r${DIR}/test-requirements.txt"
 mkdir not-${module}
 pushd not-${module}
diff --git a/setup.py b/setup.py
index bb098fb..9c1d31b 100644
--- a/setup.py
+++ b/setup.py
@@ -61,6 +61,7 @@
         "Programming Language :: Python :: 3.7",
         "Programming Language :: Python :: 3.8",
         "Programming Language :: Python :: 3.9",
+        "Programming Language :: Python :: 3.10",
         "Typing :: Typed",
     ],
 )
diff --git a/tox.ini b/tox.ini
index 52e21a3..82b219b 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,14 +1,13 @@
 [tox]
 envlist =
-  py{36,37,38,39}-lint,
-  py{36,37,38,39}-unit,
-  py{36,37,38,39}-bandit,
-  py{36,37,38,39}-mypy,
+  py{36,37,38,39,310}-lint,
+  py{36,37,38,39,310}-unit,
+  py{36,37,38,39,310}-bandit,
+  py{36,37,38,39,310}-mypy,
   py39-pipconflictchecker,
-  py39-lint-readme,
+  py39-lintreadme,
   py39-pydocstyle
 
-skipsdist = True
 skip_missing_interpreters = True
 
 [pytest]
@@ -21,42 +20,48 @@ python =
   3.7: py37
   3.8: py38
   3.9: py39
+  3.10: py310
 
 [testenv]
 description =
-  py{36,37,38,39}-unit: Run the unit tests
-  py{36,37,38,39}-lint: Lint the Python code
-  py{36,37,38,39}-bandit: Search for common security issues
-  py{36,37,38,39}-mypy: Check for type safety
+  py{36,37,38,39,310}-unit: Run the unit tests
+  py{36,37,38,39,310}-lint: Lint the Python code
+  py{36,37,38,39,310}-bandit: Search for common security issues
+  py{36,37,38,39,310}-mypy: Check for type safety
   py39-pydocstyle: docstring style checker
-  py39-lint-readme: Lint the README.rst->.md conversion
+  py39-lintreadme: Lint the README.rst->.md conversion
 
 passenv =
   CI
   GITHUB_*
 deps =
-  py{36,37,38,39}-{unit,lint,bandit,mypy}: -rrequirements.txt
-  py{36,37,38,39}-{unit,mypy}: -rtest-requirements.txt
-  py{36,37,38,39}-lint: flake8-bugbear
-  py{36,37,38,39}-lint: black
-  py{36,37,38,39}-bandit: bandit
-  py{36,37,38,39}-mypy: -rmypy_requirements.txt
+  py{36,37,38,39,310}-{unit,mypy}: -rrequirements.txt
+  py{36,37,38,39,310}-{unit,mypy}: -rtest-requirements.txt
+  py{36,37,38,39,310}-lint: flake8-bugbear
+  py{36,37,38,39,310}-lint: black
+  py{36,37,38,39,310}-bandit: bandit
+  py{36,37,38,39,310}-mypy: -rmypy-requirements.txt
 
 setenv =
-  py{36,37,38,39}-unit: LC_ALL = C.UTF-8
+  py{36,37,38,39,310}-unit: LC_ALL = C.UTF-8
 
 commands =
-  py{36,37,38,39}-unit: python -m pip install -U pip setuptools wheel
-  py{36,37,38,39}-unit: make coverage-report coverage.xml PYTEST_EXTRA={posargs}
-  py{36,37,38,39}-bandit: bandit --recursive cwltest
-  py{36,37,38,39}-lint: make flake8
-  py{36,37,38,39}-lint: make format-check
-  py{36,37,38,39}-mypy: make mypy
+  py{36,37,38,39,310}-unit: python -m pip install -U pip setuptools wheel
+  py{36,37,38,39,310}-unit: make coverage-report coverage.xml PYTEST_EXTRA={posargs}
+  py{36,37,38,39,310}-bandit: bandit --recursive cwltest --exclude cwltest/tests/*
+  py{36,37,38,39,310}-lint: make flake8
+  py{36,37,38,39,310}-lint: make format-check
+  py{36,37,38,39,310}-mypy: make mypy
 
 whitelist_externals =
-  py{36,37,38,39}-lint: flake8
-  py{36,37,38,39}-lint: black
-  py{36,37,38,39}-{mypy,shellcheck,lint,unit}: make
+  py{36,37,38,39,310}-lint: flake8
+  py{36,37,38,39,310}-lint: black
+  py{36,37,38,39,310}-{mypy,shellcheck,lint,unit}: make
+
+skip_install =
+  py{36,37,38,39,310}-lint: true
+  py{36,37,38,39,310}-bandit: true
+
 
 [testenv:py39-pydocstyle]
 whitelist_externals = make
@@ -64,6 +69,7 @@ commands = make diff_pydocstyle_report
 deps =
     pydocstyle
     diff-cover
+skip_install = true
 
 [testenv:py39-pipconflictchecker]
 commands = pipconflictchecker
@@ -72,7 +78,8 @@ deps =
   pip-conflict-checker
   pip==9.0.3
 
-[testenv:py39-lint-readme]
+[testenv:py39-lintreadme]
+description = Lint the README.rst->.md conversion
 commands =
   python setup.py sdist
   python setup.py bdist_wheel
@@ -81,3 +88,4 @@ deps =
     twine
     wheel
     readme_renderer[md]
+skip_install = true