hdac.txt

CMPD_CHEMBLID	MOLREGNO	PARENT_CMPD_CHEMBLID	PARENT_MOLREGNO	MOL_PREF_NAME	COMPOUND_KEY	MOLWEIGHT	ALOGP	PSA	NUM_RO5_VIOLATIONS	CANONICAL_SMILES	ACTIVITY_ID	STANDARD_TYPE	RELATION	STANDARD_VALUE	STANDARD_UNITS	PCHEMBL_VALUE	ACTIVITY_COMMENT	DATA_VALIDITY_COMMENT	POTENTIAL_DUPLICATE	BAO_ENDPOINT	UO_UNITS	QUDT_UNITS	ASSAY_ID	ASSAY_CHEMBLID	ASSAY_TYPE	DESCRIPTION	ASSAY_SRC_ID	ASSAY_SRC_DESCRIPTION	ASSAY_ORGANISM	ASSAY_STRAIN	ASSAY_TAX_ID	CURATED_BY	BAO_FORMAT	TID	TARGET_CHEMBLID	TARGET_TYPE	PROTEIN_ACCESSION	PREF_NAME	ORGANISM	CONFIDENCE_SCORE	TARGET_MAPPING	APD_NAME	APD_CONFIDENCE	DOC_ID	DOC_CHEMBLID	PUBMED_ID	JOURNAL	YEAR	VOLUME	ISSUE	FIRST_PAGE	CELL_ID	CELL_CHEMBL_ID	CELL_NAME
CHEMBL235674	399306	CHEMBL235674	399306		4	458.53	3.54	134.57	0	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2)c4cccs4	1998273	IC50	=	100	nM	7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	1, vorinostat	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	2161808	IC50	=	82	nM	7.09			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	476820	CHEMBL932445	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			39330	CHEMBL1144784	18370373	J. Med. Chem.	2008	51	8	2350			
CHEMBL406927	429752	CHEMBL406927	429752		18	495.01	5.11	99.87	1	COc1ccc2[nH]c(C)c(CC(=O)N[C@@H](CCCCCC(=O)C)c3nc4ccc(Cl)cc4[nH]3)c2c1	2161828	IC50	=	880	nM	6.06			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	476820	CHEMBL932445	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			39330	CHEMBL1144784	18370373	J. Med. Chem.	2008	51	8	2350			
CHEMBL27759	36237	CHEMBL27759	36237	ENTINOSTAT	3, MS-275, SNDX-275	376.41	2.07	106.33	0	Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2	2623810	IC50	=	250	nM	6.6			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	522846	CHEMBL1002514	B	Inhibition of human C-terminal FLAG-tagged HDAC2 in HEK293 cells	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46750	CHEMBL1136937	19441846	J. Med. Chem.	2009	52	11	3453	722	CHEMBL3307715	HEK293
CHEMBL1096982	627085	CHEMBL1096982	627085		3	599.68	2.53	160.69	1	OC(=O)CC\C=C/C[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC1=O	3290060	IC50	=	11400	nM	4.94			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	629198	CHEMBL1121312	B	Inhibition of full length HDAC2 expressed in HEK293 cells after 15 mins by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51141	CHEMBL1158553	20381359	Bioorg. Med. Chem.	2010	18	9	3252	722	CHEMBL3307715	HEK293
CHEMBL27759	36237	CHEMBL27759	36237	ENTINOSTAT	4, MS-275	376.41	2.07	106.33	0	Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2	3480811	IC50	=	500	nM	6.3			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	672869	CHEMBL1267844	B	Inhibition of HDAC2 by in vitro deacetylation assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			53324	CHEMBL1255383	19966789	Nat. Chem. Biol.	2010	6	1	25			
CHEMBL3356939	1821082	CHEMBL3356939	1821082		85, ST7900	417.56	2.33	117.31	0	SCCCCC[C@H](NC(=O)[C@@H]1CCCC(=O)N1)C(=O)N2CCc3ccccc3C2	15067444	Inhibition					Not Active		0	BAO_0000376			1443008	CHEMBL3379486	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate at <50 uM by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3356938	1821081	CHEMBL3356938	1821081		16, ST7817	277.42	3.48	59.11	0	SCCCCCCC(=O)N1CCc2ccccc2C1	15067445	Inhibition					Not Active		0	BAO_0000376			1443008	CHEMBL3379486	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate at <50 uM by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3338417	1792917	CHEMBL3338417	1792917		31	361.4	2.66	100.03	0	ONC(=O)c1ccc2CC[C@@H](Cc2c1)Nc3nccc(n3)c4cccnc4	15077079	IC50					Not Determined		0	BAO_0000190			1433099	CHEMBL3386356	B	Inhibition of HDAC2 (unknown origin) using fluorogenic peptide as substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			89385	CHEMBL3351740	25238284	J. Med. Chem.	2014	57	19	8026			
CHEMBL3338418	1792918	CHEMBL3338418	1792918		32	361.4	2.66	100.03	0	ONC(=O)c1ccc2CC[C@H](Cc2c1)Nc3nccc(n3)c4cccnc4	15077080	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1433099	CHEMBL3386356	B	Inhibition of HDAC2 (unknown origin) using fluorogenic peptide as substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			89385	CHEMBL3351740	25238284	J. Med. Chem.	2014	57	19	8026			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	15077081	IC50	=	240	nM	6.62			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1433099	CHEMBL3386356	B	Inhibition of HDAC2 (unknown origin) using fluorogenic peptide as substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89385	CHEMBL3351740	25238284	J. Med. Chem.	2014	57	19	8026			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	14977309	IC50	=	174.6	nM	6.76			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1444505	CHEMBL3374205	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89924	CHEMBL3351443	25462271	Eur. J. Med. Chem.	2015	89		628			
CHEMBL3354913	1819036	CHEMBL3354913	1819036		7h	485.53	4.36	112.68	0	COc1ccc(cc1)C(=O)N[C@H](COc2cccc(\C=C\C(=O)NO)c2)Cc3c[nH]c4ccccc34	14977311	IC50	=	864.5	nM	6.06			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1444505	CHEMBL3374205	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89924	CHEMBL3351443	25462271	Eur. J. Med. Chem.	2015	89		628			
CHEMBL3427743	1845139	CHEMBL3427743	1845139		3a	241.29	2.58	71.77	0	NC(=O)C1CCCc2c1[nH]nc2c3ccccc3	15255894	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL3427746	1845142	CHEMBL3427746	1845142		3c	275.73	3.25	71.77	0	NC(=O)C1CCCc2c1[nH]nc2c3cccc(Cl)c3	15255897	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL3427759	1845155	CHEMBL3427759	1845155		3o	297.37	3.74	100.01	0	NC(=O)C1CCCc2c1[nH]nc2c3cc4ccccc4s3	15255909	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL3427748	1845144	CHEMBL3427748	1845144		3e	310.18	3.91	71.77	0	NC(=O)C1CCCc2c1[nH]nc2c3ccc(Cl)c(Cl)c3	15255946	IC50	>	10000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL3427768	1845164	CHEMBL3427768	1845164		9	289.76	3.7	71.77	0	NC(=O)C1CCCCc2c1[nH]nc2c3ccc(Cl)cc3	15255995	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL3427775	1845171	CHEMBL3427775	1845171		13f, mixture of diastereomers	351.83	4.53	71.77	0	NC(=O)C1CC(Cc2c1[nH]nc2c3ccc(Cl)cc3)c4ccccc4	15256002	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL3427776	1845172	CHEMBL3427776	1845172		13g	333.77	1.74	90.23	0	NC(=O)C1CC2(Cc3c1[nH]nc3c4ccc(Cl)cc4)OCCO2	15256003	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL356066	234707	CHEMBL356066	234707	DACINOSTAT	24, LAQ-824	379.45	3.05	88.59	0	OCCN(CCc1c[nH]c2ccccc12)Cc3ccc(\C=C\C(=O)NO)cc3	1998282	IC50	=	7	nM	8.15			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL272980	434834	CHEMBL272980	434834	MOCETINOSTAT	1f	396.44	2.8	105.82	0	Nc1ccccc1NC(=O)c2ccc(CNc3nccc(n3)c4cccnc4)cc2	2106266	IC50					Not Determined		0	BAO_0000190			464924	CHEMBL946981	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38494	CHEMBL1142268	18247554	J. Med. Chem.	2008	51	6	1505			
CHEMBL484073	499961	CHEMBL484073	499961		27	327.38	2.04	91.32	0	ONC(=O)CCCCCNC(=O)\C=C\c1ccc2cccnc2c1	2306399	IC50	=	2.5	nM	8.6			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	521104	CHEMBL960365	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46897	CHEMBL1137690	18672316	Eur. J. Med. Chem.	2009	44	3	1067			
CHEMBL272980	434834	CHEMBL272980	434834	MOCETINOSTAT	8, MGCD0103	396.44	2.8	105.82	0	Nc1ccccc1NC(=O)c2ccc(CNc3nccc(n3)c4cccnc4)cc2	2450738	IC50	=	290	nM	6.54			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	492122	CHEMBL947464	B	Inhibition of human recombinant HDAC2 homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	43784	CHEMBL1155041	18570366	J. Med. Chem.	2008	51	14	4072			
CHEMBL538713	554214	CHEMBL538713	554214		3l	278.31	3.12	65.12	0	ONC(=O)\C=C\c1ccc(cc1)c2ccc3[nH]ccc3c2	2657777	IC50	=	1200	nM	5.92			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL1767037	1142076	CHEMBL1767037	1142076		21	425.48	3.29	128.09	0	CNC(=O)\C(=N/O)\CCCCCCC(=O)Nc1cccc(c1)c2ccc(cc2)C(=O)O	6174073	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL1767038	1142077	CHEMBL1767038	1142077		22	382.46	2.51	103.68	0	CNC(=O)\C(=N/O)\CCCCCCC(=O)Nc1cccc(c1)c2cccnc2	6174074	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL1767041	1142080	CHEMBL1767041	1142080		30	487.55	3.37	155.15	0	CNC(=O)\C(=N\O)\CCCCCCNC(=O)c1cc(on1)c2cccc(NC(=O)OC(C)(C)C)c2	6174077	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL1800376	1161440	CHEMBL1800376	1161440		22	276.31	2.71	108.61	0	Cc1cc(O)nc(SCC(=O)c2ccc(O)cc2)n1	6283045	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL1834362	1178406	CHEMBL1834362	1178406	N-(PHENYLCARBAMOTHIOYL)BENZAMIDE	TM-2-51	256.32	3.77	73.22	0	O=C(NC(=S)Nc1ccccc1)c2ccccc2	6377123	Inhibition	=	8	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	771822	CHEMBL1838694	B	Inhibition of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1800384	1161448	CHEMBL1800384	1161448		31	331.43	3.57	100.41	0	Cc1cc(O)nc(SCC(=O)NCCCCc2ccccc2)n1	6283054	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	3311479	Ki	=	40	nM	7.4			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	633817	CHEMBL1119895	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51319	CHEMBL1155491	20451378	Bioorg. Med. Chem. Lett.	2010	20	11	3314			
CHEMBL2047612	1351036	CHEMBL2047612	1351036		6d	425.48	5.22	65.38	1	COc1ccc(NC(=O)\C=C/c2cn(nc2c3ccc(OC)cc3)c4ccccc4)cc1	10947979	IC50	=	3020	nM	5.52			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	827843	CHEMBL2051252	B	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62524	CHEMBL2046430	22705022	Bioorg. Med. Chem.	2012	20	14	4430			
CHEMBL2022823	1338195	CHEMBL2022823	1338195		1	559.74	7.46	130.92	2	O=C(N[C@@H](CCCCCCSSc1ccccn1)C(=O)Nc2cccc3ccccc23)OCc4ccccc4	10862518	IC50	=	38.2	nM	7.42			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	816365	CHEMBL2024763	B	Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	61731	CHEMBL2021837	22465091	Eur. J. Med. Chem.	2012	52		111			
CHEMBL356769	239841	CHEMBL356769	239841	TUBACIN	Tubacin	721.86	7.18	168.45	2	OCc1ccc(cc1)[C@@H]2C[C@H](CSc3oc(c4ccccc4)c(n3)c5ccccc5)O[C@@H](O2)c6ccc(NC(=O)CCCCCCC(=O)NO)cc6	14992236	IC50	=	6270	nM	5.2			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1431996	CHEMBL3388101	B	Inhibition of full length C-terminal 6x-His tagged human HDAC2 using Arg-His-Lys-Lys(Ac) substrate incubated for 2 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89845	CHEMBL3351349	25454270	Bioorg. Med. Chem. Lett.	2014	24	23	5450			
CHEMBL3309299	1778387	CHEMBL3309299	1778387		42	399.48	2.38	107.52	0	CC1(C)CC(=O)Nc2ccc(cc12)C(=O)NC[C@@H]3CC[C@@H](CC3)\C=C\C(=O)NO	15053565	IC50	=	310	nM	6.51			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1450057	CHEMBL3373319	B	Inhibition of human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90190	CHEMBL3351757	24864038	Bioorg. Med. Chem.	2014	22	14	3720			
CHEMBL3356525	1820664	CHEMBL3356525	1820664		144, ST8023	377.5	2.04	126.1	0	SCCCCC[C@@H](NC(=O)[C@@H]1CCCC(=O)N1)C(=O)Nc2ccccc2	15067391	Inhibition					Not Active		0	BAO_0000376			1443008	CHEMBL3379486	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate at <50 uM by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3427754	1845150	CHEMBL3427754	1845150		3j	255.31	3.07	71.77	0	Cc1ccc(cc1)c2n[nH]c3C(CCCc23)C(=O)N	15255904	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL3427764	1845160	CHEMBL3427764	1845160		3t	328.8	4.04	76.69	0	Cn1c(cc2cc(Cl)ccc12)c3n[nH]c4C(CCCc34)C(=O)N	15255968	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL404054	436479	CHEMBL404054	436479		17	466.54	4.01	143.87	0	Nc1ccccc1NC(=O)c2ccc(CNc3nc(N)nc(NC4Cc5ccccc5C4)n3)cc2	2097996	Activity					Active		0	BAO_0000375			468079	CHEMBL931663	B	Activity against HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38730	CHEMBL1143113	18160287	Bioorg. Med. Chem. Lett.	2008	18	3	1067			
CHEMBL1095095	626202	CHEMBL1095095	626202		8	278.31	2.49	68.26	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3cocc3	3286367	Ratio IC50	=	21					0	BAO_0000179			630933	CHEMBL1116532	B	Selectivity ratio of IC50 for human recombinant HDAC2 preincubated for 1 hr with substrate to IC50 for human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1095095	626202	CHEMBL1095095	626202		8	278.31	2.49	68.26	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3cocc3	3286386	IC50	=	39	nM	7.41			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1095095	626202	CHEMBL1095095	626202		8	278.31	2.49	68.26	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3cocc3	3286406	IC50	=	810	nM	6.09			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL400141	416500	CHEMBL400141	416500		4d	320.38	2.23	87.66	0	CC(=C)COC(CCCCC(=O)NO)C(=O)Nc1ccccc1	2049596	Activity					Not Active		0	BAO_0000375			458150	CHEMBL925483	B	Inhibition of HDAC2 in HeLa cell lysates at 0.1 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL217651	363494	CHEMBL217651	363494		29	470.63	3.67	119.64	0	CN1CCCCC1C(=O)N[C@@H](CCCCCC(=O)C)C(=O)Nc2nc(cs2)c3ccccc3	1792262	IC50	=	170	nM	6.77			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	422130	CHEMBL907066	B	Inhibition of HDAC2 (mean IC50)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	34712	CHEMBL1137275	16987657	Bioorg. Med. Chem. Lett.	2006	16	23	5948			
CHEMBL236678	399038	CHEMBL236678	399038		7	213.24	.72	68	0	Nc1ccccc1NC(=O)c2cccnc2	2401162	IC50	=	6980	nM	5.16			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	493107	CHEMBL940370	B	Inhibition of human HDAC2 expressed in mammalian cells	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45872	CHEMBL1152282	18951790	Bioorg. Med. Chem. Lett.	2008	18	23	6104			
CHEMBL467793	488395	CHEMBL467793	488395		9	346.38	1.79	130.47	0	Nc1ccc(cc1)c2onc(c2)C(=O)NCCCCCCC(=O)NO	2569572	IC50	=	147	nM	6.83			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	514670	CHEMBL976442	B	Inhibition of HDAC2 after 17 hrs	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			44070	CHEMBL1155917	18642892	J. Med. Chem.	2008	51	15	4370			
CHEMBL564382	564503	CHEMBL564382	564503		4o, ST2887	407.46	5.16	80.91	1	ONC(=O)\C=C\c1ccc(cc1)C(c2c[nH]c3ccccc23)c4c[nH]c5ccccc45	2720675	IC50	=	3900	nM	5.41			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	585885	CHEMBL1053556	B	Inhibition of human HDAC2 by fluorimetry	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	48183	CHEMBL1153591	19359173	Bioorg. Med. Chem. Lett.	2009	19	10	2840			
CHEMBL2047606	1351030	CHEMBL2047606	1351030		5b	413.9	6.41	46.92	1	Cc1ccc(cc1)c2nn(cc2\C=C/C(=O)Nc3ccc(Cl)cc3)c4ccccc4	10947973	IC50	=	5860	nM	5.23			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	827843	CHEMBL2051252	B	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62524	CHEMBL2046430	22705022	Bioorg. Med. Chem.	2012	20	14	4430			
CHEMBL2047618	1351042	CHEMBL2047618	1351042		8b	444.87	5.81	92.74	1	[O-][N+](=O)c1ccc(cc1)c2nn(cc2\C=C/C(=O)Nc3ccc(Cl)cc3)c4ccccc4	10947985	IC50	=	570	nM	6.24			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	827843	CHEMBL2051252	B	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62524	CHEMBL2046430	22705022	Bioorg. Med. Chem.	2012	20	14	4430			
CHEMBL2047620	1351044	CHEMBL2047620	1351044		8d	440.45	5.13	101.97	1	COc1ccc(NC(=O)\C=C/c2cn(nc2c3ccc(cc3)[N+](=O)[O-])c4ccccc4)cc1	10947987	IC50	=	1150	nM	5.94			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	827843	CHEMBL2051252	B	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62524	CHEMBL2046430	22705022	Bioorg. Med. Chem.	2012	20	14	4430			
CHEMBL3356923	1821066	CHEMBL3356923	1821066		87, ST8083	377.5	2.07	126.1	0	Cc1cccc(NC(=O)[C@H](CCCCCS)NC(=O)[C@H]2CCC(=O)N2)c1	15138232	IC50	=	14	nM	7.85			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3356524	1820663	CHEMBL3356524	1820663		126, ST7896	377.5	2.04	126.1	0	SCCCCC[C@H](NC(=O)[C@H]1CCCC(=O)N1)C(=O)Nc2ccccc2	15138243	IC50	=	34	nM	7.47			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3352995	1817098	CHEMBL3352995	1817098		7c	541.64	2.08	169.48	2	CC(C)[C@H]1NC(=O)C[C@@H](CCCCCC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](C)NC1=O	15126327	Ki	=	300	nM	6.52			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	1440125	CHEMBL3382538	B	Inhibition of human recombinant HDAC2 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89689	CHEMBL3351463	25380299	J. Med. Chem.	2014	57	22	9644			
CHEMBL3098604	1609374	CHEMBL3098604	1609374		6	404.46	.89	136.63	0	Cc1cccc(NC(=O)[C@H](CCCCCC(=O)NO)NC(=O)[C@H]2CCC(=O)N2)c1	14976175	IC50	=	27	nM	7.57			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1444620	CHEMBL3376039	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90082	CHEMBL3352629	25563890	Bioorg. Med. Chem. Lett.	2015	25	3	459			
CHEMBL1213490	685334	CHEMBL1213490	685334	ROMIDEPSIN	FK228	541.72	2.26	208.27	1	C\C=C\1/NC(=O)[C@@H](CS)NC(=O)[C@H](CC(=O)C[C@H](OC(=O)[C@@H](NC1=O)C(C)C)\C=C\CCS)C(C)C	15136618	IC50	=	1	nM	9			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1455096	CHEMBL3366352	B	Inhibition of HDAC2 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90823	CHEMBL3352121	25147612	ACS Med. Chem. Lett.	2014	5	8	905			
CHEMBL3427750	1845146	CHEMBL3427750	1845146		3g	293.72	3.45	71.77	0	NC(=O)C1CCCc2c1[nH]nc2c3ccc(Cl)c(F)c3	15255900	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL3427770	1845166	CHEMBL3427770	1845166		13a	303.79	3.71	71.77	0	CC1(C)CC(C(=O)N)c2[nH]nc(c2C1)c3ccc(Cl)cc3	15255997	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL507114	519578	CHEMBL507114	519578		13b	336.41	.65	122.56	0	NS(=O)(=O)NCCCCCC(=O)Nc1cccc2cccnc12	2600489	Activity					Not Active		0	BAO_0000375			540708	CHEMBL1027321	B	Inhibition of human recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus by fluorimetry	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			46637	CHEMBL1149076	19084395	Bioorg. Med. Chem. Lett.	2009	19	2	336			
CHEMBL538364	554220	CHEMBL538364	554220		10b	295.33	3.28	58.56	0	COc1ccc(cc1)c2ccc(\C=C\C=C\C(=O)NO)cc2	2658574	IC50	>	5000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL1213490	685334	CHEMBL1213490	685334	ROMIDEPSIN	3, FK-228	541.72	2.26	208.27	1	C\C=C\1/NC(=O)[C@@H](CS)NC(=O)[C@H](CC(=O)C[C@H](OC(=O)[C@@H](NC1=O)C(C)C)\C=C\CCS)C(C)C	13431789	Ki	=	.038	nM	10.42			1	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	979441	CHEMBL2423477	B	Inhibition of recombinant human HDAC2 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74596	CHEMBL2417416	23865683	J. Med. Chem.	2013	56	16	6512			
CHEMBL249604	416496	CHEMBL249604	416496		4c	306.36	1.79	87.66	0	ONC(=O)CCCCC(OCC=C)C(=O)Nc1ccccc1	2049597	Activity					Not Active		0	BAO_0000375			458150	CHEMBL925483	B	Inhibition of HDAC2 in HeLa cell lysates at 0.1 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL2178221	1439014	CHEMBL2178221	1439014		49	505.01	3.24	107.69	1	Nc1ccccc1NC(=O)\C=C\c2ccc(cc2)[C@H]3CN(CCO)C[C@@H]3C(=O)Nc4ccc(Cl)cc4	12136059	IC50					Not Determined		0	BAO_0000190			874014	CHEMBL2186139	B	Inhibition of HDAC2 using p53 (379 to 382 residues) based fluorogenic peptide substrate	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			66641	CHEMBL2177000	23061376	J. Med. Chem.	2012	55	20	8903			
CHEMBL2347008	1528832	CHEMBL2347008	1528832		14, atorva-HA	573.65	4.94	123.82	1	CC(C)c1c(C(=O)Nc2ccccc2)c(c3ccccc3)c(c4ccc(F)cc4)n1CC[C@@H](O)C[C@@H](O)CC(=O)NO	12718182	IC50	=	467.2	nM	6.33			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	950484	CHEMBL2351477	B	Inhibition of recombinant HDAC2 (unknown origin) after 10 mins by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72873	CHEMBL2346500	23570542	J. Med. Chem.	2013	56	9	3645			
CHEMBL3356931	1821074	CHEMBL3356931	1821074		133, ST7786	369.52	1.86	126.1	0	SCCCCC[C@H](NC(=O)[C@@H]1CCCC(=O)N1)C(=O)NC2CCCC2	15138286	IC50	=	454	nM	6.34			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL261735	429709	CHEMBL261735	429709		19	500.63	5.29	99.86	2	CCC(=O)CCCCC[C@H](NC(=O)Cc1c(C)[nH]c2ccc(OC)cc12)c3ncc([nH]3)c4ccccc4	2161827	IC50	=	59	nM	7.23			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	476820	CHEMBL932445	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			39330	CHEMBL1144784	18370373	J. Med. Chem.	2008	51	8	2350			
CHEMBL492174	461404	CHEMBL492174	461404		(R)-21					OB(O)CCCCC[C@@H](NC(=O)c1cncs1)C(=O)Nc2cccc(c2)c3ccccc3	2513611	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	498746	CHEMBL1021938	B	Inhibition of human recombinant HDAC2 by fluorimetry	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			47121	CHEMBL1138526	19419205	J. Med. Chem.	2009	52	9	2909			
CHEMBL492097	461331	CHEMBL492097	461331		(S)-21					OB(O)CCCCC[C@H](NC(=O)c1cncs1)C(=O)Nc2cccc(c2)c3ccccc3	2513648	IC50	=	530	nM	6.28			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	498746	CHEMBL1021938	B	Inhibition of human recombinant HDAC2 by fluorimetry	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47121	CHEMBL1138526	19419205	J. Med. Chem.	2009	52	9	2909			
CHEMBL479842	473679	CHEMBL479842	473679		7b	387.43	3.44	81.67	0	ONC(=O)c1ccc(CN2[C@H](Cc3ccccc3)C(=O)Nc4ccccc24)cc1	2489475	IC50	=	260	nM	6.59			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	515266	CHEMBL991290	B	Inhibition of human recombinant histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45582	CHEMBL1143301	19111466	Bioorg. Med. Chem. Lett.	2009	19	3	688			
CHEMBL483693	508338	CHEMBL483693	508338		10a	421.49	3.72	109.14	0	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)c2cn(Cc3ccccc3)nn2	2351865	IC50	=	43	nM	7.37			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL513568	516934	CHEMBL513568	516934		12	433.57	2.91	111.52	0	Nc1ccc(cc1NC(=O)c2ccc(nc2)N3CCC4(CCNC4)CC3)c5cccs5	2380644	IC50	=	44	nM	7.36			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	493107	CHEMBL940370	B	Inhibition of human HDAC2 expressed in mammalian cells	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45872	CHEMBL1152282	18951790	Bioorg. Med. Chem. Lett.	2008	18	23	6104			
CHEMBL556332	563010	CHEMBL556332	563010		3a	255.27	2.59	69.56	0	ONC(=O)\C=C\c1ccc(cc1)c2ccc(O)cc2	2657757	IC50	=	590	nM	6.23			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL561411	559444	CHEMBL561411	559444		7	255.27	2.35	58.56	0	ONC(=O)\C=C\Oc1ccc(cc1)c2ccccc2	2658591	IC50					Not Determined		0	BAO_0000190			571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL609583	592384	CHEMBL609583	592384		1, R306465	413.45	1.24	124.11	0	ONC(=O)c1cnc(nc1)N2CCN(CC2)S(=O)(=O)c3ccc4ccccc4c3	3079136	IC50	=	9	nM	8.05			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	605911	CHEMBL1068528	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	49395	CHEMBL1153112	19906529	Bioorg. Med. Chem. Lett.	2010	20	1	294			
CHEMBL1088735	614582	CHEMBL1088735	614582		4f	437.49	3.48	129.37	0	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)c2cn(Cc3ccc(O)cc3)nn2	3201419	IC50					Not Determined		0	BAO_0000190			616013	CHEMBL1101057	B	Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			50398	CHEMBL1154884	20055418	J. Med. Chem.	2010	53	3	1347			
CHEMBL408513	435188	CHEMBL408513	435188	BELINOSTAT	10, PXD-101	318.35	1.8	103.88	0	ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)Nc2ccccc2	3389988	Ki	=	.85	nM	9.07			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL2022824	1338196	CHEMBL2022824	1338196		2	515.73	6.83	130.92	2	O=C(N[C@@H](CCCCCCSSc1ccccn1)C(=O)NC2CCCCC2)OCc3ccccc3	10862521	IC50	=	44.1	nM	7.36			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	816365	CHEMBL2024763	B	Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	61731	CHEMBL2021837	22465091	Eur. J. Med. Chem.	2012	52		111			
CHEMBL402718	416380	CHEMBL402718	416380		4f	356.42	2.75	87.66	0	ONC(=O)CCCCC(OCc1ccccc1)C(=O)Nc2ccccc2	2049523	IC50	=	500	nM	6.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL235191	399340	CHEMBL235191	399340	TACEDINALINE	18, pfizer,CI-994	269.3	.99	84.22	0	CC(=O)Nc1ccc(cc1)C(=O)Nc2ccccc2N	1998346	Inhibition	<	50	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	451049	CHEMBL900130	B	Inhibition of human recombinant HDAC2 at 20 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL400721	423537	CHEMBL400721	423537		15f	381.45	3.11	121.69	0	COC(=O)NCc1ccc(cc1)C(=O)Nc2cc(ccc2N)c3cccs3	2073948	IC50	=	105	nM	6.98			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	461756	CHEMBL927762	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38240	CHEMBL1140803	18060775	Bioorg. Med. Chem. Lett.	2008	18	2	726			
CHEMBL139192	232023	CHEMBL139192	232023		TWZ 104	278.35	2.34	69.64	0	ON(CCCCCCCC(=O)Nc1ccccc1)C=O	1301829	IC50	=	7800	nM	5.11			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	87875	CHEMBL697297	B	Inhibition of Histone deacetylase 2 (HDAC2) activity of HeLa nuclear extracts	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	6553	CHEMBL1137945	14698179	Bioorg. Med. Chem. Lett.	2004	14	2	449			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	II, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	2306397	IC50	=	163.6	nM	6.79			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	521104	CHEMBL960365	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46897	CHEMBL1137690	18672316	Eur. J. Med. Chem.	2009	44	3	1067			
CHEMBL492140	461328	CHEMBL492140	461328		(R)-18					OB(O)CCCCC[C@@H](NC(=O)c1ccccc1)C(=O)Nc2cccc(c2)c3ccccc3	2513601	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	498746	CHEMBL1021938	B	Inhibition of human recombinant HDAC2 by fluorimetry	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			47121	CHEMBL1138526	19419205	J. Med. Chem.	2009	52	9	2909			
CHEMBL491926	461330	CHEMBL491926	461330		(R)-20					OB(O)CCCCC[C@@H](NC(=O)c1cccnc1)C(=O)Nc2cccc(c2)c3ccccc3	2513606	IC50	=	99000	nM	4			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	498746	CHEMBL1021938	B	Inhibition of human recombinant HDAC2 by fluorimetry	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47121	CHEMBL1138526	19419205	J. Med. Chem.	2009	52	9	2909			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	2, (SAHA, vorinostat)	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	2513667	IC50	=	250	nM	6.6			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	498746	CHEMBL1021938	B	Inhibition of human recombinant HDAC2 by fluorimetry	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47121	CHEMBL1138526	19419205	J. Med. Chem.	2009	52	9	2909			
CHEMBL353581	273911	CHEMBL353581	273911	PYROXAMIDE	13	265.31	.86	91.32	0	ONC(=O)CCCCCCC(=O)Nc1cccnc1	3389997	Ki	=	36000	nM	4.44			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	1, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	3390003	Ki	=	1.6	nM	8.8			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL320497	183870	CHEMBL320497	183870	SUBEROHYDROXAMIC ACID	16, SHA	204.22	.24	98.66	0	ONC(=O)CCCCCCC(=O)NO	3390018	Ki	=	29	nM	7.54			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	8	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	3390024	Ki	=	.65	nM	9.19			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL1093033	620617	CHEMBL1093033	620617		32	449.56	5.85	68.36	1	CC(C)(C)c1[nH]c2ccccc2c1[C@H]3CCCN(Cc4ccc(\C=C\C(=O)NO)cc4F)C3	3259661	IC50	=	31	nM	7.51			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	625339	CHEMBL1111713	B	Inhibition of HDAC2 expressed in baculovirus system by fluorescent assay	1	Scientific Literature				Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			50650	CHEMBL1156307	20205394	J. Med. Chem.	2010	53	7	2952			
CHEMBL235191	399340	CHEMBL235191	399340	TACEDINALINE	20, CI-994	269.3	.99	84.22	0	CC(=O)Nc1ccc(cc1)C(=O)Nc2ccccc2N	3389928	Ki	=	190	nM	6.72			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL1213492	685336	CHEMBL1213492	685336		9, ITF-2357	421.49	3.87	90.9	0	CCN(CC)Cc1ccc2cc(COC(=O)Nc3ccc(cc3)C(=O)NO)ccc2c1	3389947	Ki	=	3	nM	8.52			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	3286372	IC50	=	72	nM	7.14			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1098337	626352	CHEMBL1098337	626352		20	306.33	3.59	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccc(F)cc3	3286374	IC50	=	32	nM	7.49			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	3286392	IC50	=	76	nM	7.12			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1098337	626352	CHEMBL1098337	626352		20	306.33	3.59	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccc(F)cc3	3286394	IC50	=	1400	nM	5.85			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL562757	566560	CHEMBL562757	566560		3f	267.28	2.59	66.4	0	ONC(=O)\C=C\c1ccc(cc1)c2ccc(C=O)cc2	2658582	IC50					Not Determined		0	BAO_0000190			571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL272980	434834	CHEMBL272980	434834	MOCETINOSTAT	A, MGCD0103	396.44	2.8	105.82	0	Nc1ccccc1NC(=O)c2ccc(CNc3nccc(n3)c4cccnc4)cc2	2489833	IC50	=	290	nM	6.54			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	515333	CHEMBL1036510	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			45586	CHEMBL1143305	19114304	Bioorg. Med. Chem. Lett.	2009	19	3	644			
CHEMBL272980	434834	CHEMBL272980	434834	MOCETINOSTAT	MGCD0103	396.44	2.8	105.82	0	Nc1ccccc1NC(=O)c2ccc(CNc3nccc(n3)c4cccnc4)cc2	2922864	IC50	=	180	nM	6.74			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	591998	CHEMBL1048395	B	Inhibition of recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus after 10 mins by fluorimetric analysis	1	Scientific Literature				Intermediate	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			48688	CHEMBL1155182	19699639	Bioorg. Med. Chem. Lett.	2009	19	19	5684			
CHEMBL356066	234707	CHEMBL356066	234707	DACINOSTAT	LAQ	379.45	3.05	88.59	0	OCCN(CCc1c[nH]c2ccccc12)Cc3ccc(\C=C\C(=O)NO)cc3	2922865	IC50	=	10	nM	8			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	591998	CHEMBL1048395	B	Inhibition of recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus after 10 mins by fluorimetric analysis	1	Scientific Literature				Intermediate	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			48688	CHEMBL1155182	19699639	Bioorg. Med. Chem. Lett.	2009	19	19	5684			
CHEMBL483254	499179	CHEMBL483254	499179	PANOBINOSTAT	11, LBH-589	349.43	3.19	77.15	0	Cc1[nH]c2ccccc2c1CCNCc3ccc(\C=C\C(=O)NO)cc3	3389965	Ki	=	.65	nM	9.19			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL272980	434834	CHEMBL272980	434834	MOCETINOSTAT	18, MGCD-0103	396.44	2.8	105.82	0	Nc1ccccc1NC(=O)c2ccc(CNc3nccc(n3)c4cccnc4)cc2	3389974	Ki	=	32.4	nM	7.49			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL1097278	626134	CHEMBL1097278	626134		4	295.36	2.25	96.25	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3nccs3	3286370	Ratio IC50	=	14					0	BAO_0000179			630933	CHEMBL1116532	B	Selectivity ratio of IC50 for human recombinant HDAC2 preincubated for 1 hr with substrate to IC50 for human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1097278	626134	CHEMBL1097278	626134		4	295.36	2.25	96.25	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3nccs3	3286390	IC50	=	390	nM	6.41			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1097278	626134	CHEMBL1097278	626134		4	295.36	2.25	96.25	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3nccs3	3286410	IC50	=	5800	nM	5.24			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL356066	234707	CHEMBL356066	234707	DACINOSTAT	NVP-LAQ824	379.45	3.05	88.59	0	OCCN(CCc1c[nH]c2ccccc12)Cc3ccc(\C=C\C(=O)NO)cc3	5090666	IC50	=	15.7	nM	7.8			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	690171	CHEMBL1634301	B	Inhibition of human HDAC2 by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	54338	CHEMBL1629537	21073160	J. Med. Chem.	2010	53	23	8387			
CHEMBL1767042	1142081	CHEMBL1767042	1142081		31	487.55	3.37	155.15	0	CNC(=O)\C(=N\O)\CCCCCCNC(=O)c1cc(on1)c2ccc(NC(=O)OC(C)(C)C)cc2	6174078	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL483254	499179	CHEMBL483254	499179	PANOBINOSTAT	LBH589	349.43	3.19	77.15	0	Cc1[nH]c2ccccc2c1CCNCc3ccc(\C=C\C(=O)NO)cc3	6370663	Ki	=	1.9	nM	8.72			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	769058	CHEMBL1832521	B	Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58940	CHEMBL1828590	21634430	J. Med. Chem.	2011	54	13	4694			
CHEMBL2057824	1353579	CHEMBL2057824	1353579		1b	335.38	4.03	133.11	0	Nc1ccc(cc1NC(=O)c2ccc(cc2)N=[N+]=[N-])c3cccs3	10955038	Inhibition					Active		0	BAO_0000376			829166	CHEMBL2059988	B	Inhibition of HDAC2 in human MDA-MB-231 cells assessed as inhibition of H4 deacetylation at 50 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025	325	CHEMBL3307960	MDA-MB-231
CHEMBL2057824	1353579	CHEMBL2057824	1353579		1b	335.38	4.03	133.11	0	Nc1ccc(cc1NC(=O)c2ccc(cc2)N=[N+]=[N-])c3cccs3	10954400	Ratio IC50	=	4.6					0	BAO_0000179			829156	CHEMBL2059978	B	Ratio of IC50 for human HDAC2 preincubated for 3 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057824	1353579	CHEMBL2057824	1353579		1b	335.38	4.03	133.11	0	Nc1ccc(cc1NC(=O)c2ccc(cc2)N=[N+]=[N-])c3cccs3	10954413	Ratio IC50	=	29					0	BAO_0000179			829157	CHEMBL2059979	B	Ratio of IC50 for human HDAC2 preincubated for 24 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057824	1353579	CHEMBL2057824	1353579		1b	335.38	4.03	133.11	0	Nc1ccc(cc1NC(=O)c2ccc(cc2)N=[N+]=[N-])c3cccs3	10954450	Inhibition					tde		0	BAO_0000376			829163	CHEMBL2059985	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057824	1353579	CHEMBL2057824	1353579		1b	335.38	4.03	133.11	0	Nc1ccc(cc1NC(=O)c2ccc(cc2)N=[N+]=[N-])c3cccs3	10954270	IC50	=	3200	nM	5.49			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829146	CHEMBL2059968	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 5 mins measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057824	1353579	CHEMBL2057824	1353579		1b	335.38	4.03	133.11	0	Nc1ccc(cc1NC(=O)c2ccc(cc2)N=[N+]=[N-])c3cccs3	10954283	IC50	=	690	nM	6.16			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829147	CHEMBL2059969	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 3 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057824	1353579	CHEMBL2057824	1353579		1b	335.38	4.03	133.11	0	Nc1ccc(cc1NC(=O)c2ccc(cc2)N=[N+]=[N-])c3cccs3	10954296	IC50	=	110	nM	6.96			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829148	CHEMBL2059970	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 24 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL430060	275631	CHEMBL430060	275631	APICIDIN	4	623.78	1.58	138.84	1	CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cn(OC)c3ccccc23)NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]4CCCCN4C1=O	10981400	IC50	=	35	nM	7.46			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	831128	CHEMBL2065941	B	Inhibition of recombinant HDAC2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			62769	CHEMBL2062402		ACS Med. Chem. Lett.	2012	3	6	505			
CHEMBL2047610	1351034	CHEMBL2047610	1351034		6b	429.9	5.9	56.15	1	COc1ccc(cc1)c2nn(cc2\C=C/C(=O)Nc3ccc(Cl)cc3)c4ccccc4	10947977	IC50	=	2360	nM	5.63			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	827843	CHEMBL2051252	B	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62524	CHEMBL2046430	22705022	Bioorg. Med. Chem.	2012	20	14	4430			
CHEMBL2047619	1351043	CHEMBL2047619	1351043		8c	489.32	5.9	92.74	1	[O-][N+](=O)c1ccc(cc1)c2nn(cc2\C=C/C(=O)Nc3ccc(Br)cc3)c4ccccc4	10947986	IC50	=	550	nM	6.26			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	827843	CHEMBL2051252	B	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62524	CHEMBL2046430	22705022	Bioorg. Med. Chem.	2012	20	14	4430			
CHEMBL2170018	1429497	CHEMBL2170018	1429497		10	680.88	3.04	160.77	1	CCC(=O)CCCCC[C@@H]1NC(=O)[C@H](CCCCNC(=O)C)NC(=O)CCN(CC(C)C)C(=O)CN(CCc2c[nH]c3ccccc23)C1=O	12103871	IC50	=	370	nM	6.43			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	861541	CHEMBL2174389	B	Inhibition of human recombinant HDAC2 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	65900	CHEMBL2169795		ACS Med. Chem. Lett.	2012	3	9	749			
CHEMBL2347005	1528829	CHEMBL2347005	1528829		10					C[C@@H]1C[C@H](OC(=O)NCCCCCCC(=O)NO)[C@@H]2[C@@H](CC[C@@H]3C[C@H](CC(=O)O3)O[Si](C)(C)C(C)(C)C)[C@@H](C)C=CC2=C1	12718185	IC50	=	657.7	nM	6.18			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	950484	CHEMBL2351477	B	Inhibition of recombinant HDAC2 (unknown origin) after 10 mins by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72873	CHEMBL2346500	23570542	J. Med. Chem.	2013	56	9	3645			
CHEMBL2347010	1528834	CHEMBL2347010	1528834		6a					C[C@@H]1C[C@H](OC(=O)Nc2ccc(cc2)c3cn(CCCCCCC(=O)NO)nn3)[C@@H]4[C@@H](CC[C@@H]5C[C@H](CC(=O)O5)O[Si](C)(C)C(C)(C)C)[C@@H](C)C=CC4=C1	12718187	IC50	=	463.3	nM	6.33			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	950484	CHEMBL2351477	B	Inhibition of recombinant HDAC2 (unknown origin) after 10 mins by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72873	CHEMBL2346500	23570542	J. Med. Chem.	2013	56	9	3645			
CHEMBL430060	275631	CHEMBL430060	275631	APICIDIN	1	623.78	1.58	138.84	1	CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cn(OC)c3ccccc23)NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]4CCCCN4C1=O	12103875	IC50	=	34	nM	7.47			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	861541	CHEMBL2174389	B	Inhibition of human recombinant HDAC2 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	65900	CHEMBL2169795		ACS Med. Chem. Lett.	2012	3	9	749			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	12622653	IC50	=	32.1	nM	7.49			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	936031	CHEMBL2318997	B	Inhibition of human HDAC2 by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	71849	CHEMBL2311425	23252603	J. Med. Chem.	2013	56	2	427			
CHEMBL227118	382030	CHEMBL227118	382030		5	323.43	1.86	90.46	0	ONC(=O)CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2	13431379	IC50	=	2580	nM	5.59			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	977749	CHEMBL2424296	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74749	CHEMBL2417402	23627282	J. Med. Chem.	2013	56	16	6297			
CHEMBL2425964	1581083	CHEMBL2425964	1581083		3l	377.44	3.55	82	0	CC(C)C1=Nc2cc(\C=C\C(=O)NO)ccc2C(=O)N1CCc3ccccc3	13451917	IC50					Not Determined		0	BAO_0000190			983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL2407729	1572135	CHEMBL2407729	1572135		8i	440.45	2.43	143.12	0	Nc1cc(ccc1NC(=O)c2ccc(CNc3nccc(n3)c4cccnc4)cc2)C(=O)O	13395019	IC50	>	20000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL2431902	1583963	CHEMBL2431902	1583963		5b	276.33	1.8	69.64	0	CC(C)(C)C(=O)N1CCc2cc(ccc2C1)C(=O)NO	13467574	IC50	>	50000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	984990	CHEMBL2433164	B	Inhibition of full length C-terminal His6x-tagged recombinant human HDAC2 expressed in baculovirus using Arg-His-Lys-Lys (Ac) as substrate after 1 hr by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75006	CHEMBL2429834	23964961	J. Med. Chem.	2013	56	18	7201			
CHEMBL556	15938	CHEMBL556	15938	DEFEROXAMINE	Deferoxamine, Desferal	560.68	-.89	205.84	2	CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN	13488731	Inhibition					Not Active		0	BAO_0000376			987733	CHEMBL2439711	B	Inhibition of HDAC2 (unknown origin)-mediated deacetylation at 10 uM preincubated for 5 mins prior to substrate addition measured after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75182	CHEMBL2434956	24074025	J. Med. Chem.	2013	56	20	7997			
CHEMBL3110001	1615207	CHEMBL3110001	1615207		49	305.33	1.97	75.11	0	ONC(=O)[C@@H]1[C@@H]([C@H]1c2ccc3nccnc3c2)c4ccccc4	13896923	IC50	>	50000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1287880	CHEMBL3112164	B	Inhibition of human recombinant full length HDAC2 using (Ac)Arg-Gly-Lys(Ac) as substrate after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			76664	CHEMBL3108758	24261862	J. Med. Chem.	2013	56	24	9934			
CHEMBL2323285	1517442	CHEMBL2323285	1517442		6	605.77	3.9	211.59	1	CCCCCCCC(=O)SCC\C=C\[C@@H]1CC(=O)NCc2nc(cs2)c3nnn(CC(=O)N[C@@H](C(C)C)C(=O)O1)n3	12659628	IC50	=	30800	nM	4.51			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	938235	CHEMBL2328538	B	Inhibition of C-terminal His-tagged full length human recombinant HDAC2 expressed in baculovirus expression system using fluorogenic acetylated peptide as substrate preincubated with enzyme for 10 mins prior to substrate addition measured after 60 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72033	CHEMBL2321647		ACS Med. Chem. Lett.	2013	4	1	132			
CHEMBL16300	17490	CHEMBL16300	17490	BENZOHYDROXAMATE	8	137.14	.84	49.33	0	ONC(=O)c1ccccc1	12680994	IC50	=	7910	nM	5.1			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	944722	CHEMBL2340968	B	Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772			
CHEMBL2333338	1522976	CHEMBL2333338	1522976		2	306.36	.15	84.91	0	CN1CCN(CCNC(=O)c2ccc(cc2)C(=O)NO)CC1	12681000	IC50	=	16790	nM	4.77			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	944722	CHEMBL2340968	B	Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772			
CHEMBL16300	17490	CHEMBL16300	17490	BENZOHYDROXAMATE	8	137.14	.84	49.33	0	ONC(=O)c1ccccc1	12678226	Inhibition					Not Active		0	BAO_0000376			944716	CHEMBL2340962	B	Inhibition of HDAC2 in human HeLa cells assessed as increase in acetylated H3 at 30 uM measured after 24 hrs by Western blotting analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772	308	CHEMBL3308376	HeLa
CHEMBL2425966	1581085	CHEMBL2425966	1581085		3n	381.4	3.29	82	0	CCC1=Nc2cc(\C=C\C(=O)NO)ccc2C(=O)N1CCc3ccc(F)cc3	13451915	IC50	=	6880	nM	5.16			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL2425955	1581074	CHEMBL2425955	1581074		3c	321.33	2.09	82	0	CC1=Nc2cc(\C=C\C(=O)NO)ccc2C(=O)N1c3ccccc3	13451928	IC50	=	1610	nM	5.79			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL2407725	1572131	CHEMBL2407725	1572131		24i	478.61	5.5	104.81	1	Nc1ccccc1NC(=O)c2ccc(CNC3=N[C@H]([C@@H](S3)c4ccccc4)c5ccccc5)cc2	13395000	IC50	=	538	nM	6.27			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	1, SAHA, vorinostat	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	13331207	IC50	=	90	nM	7.05			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	961399	CHEMBL2387804	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	73722	CHEMBL2384983	23591111	Bioorg. Med. Chem. Lett.	2013	23	11	3346			
CHEMBL3347516	1796947	CHEMBL3347516	1796947		35	354.45	2.28	110.24	0	Nc1ccccc1NC(=O)CCCCCCC(=O)Nc2ccccc2N	14927518	IC50	=	4800	nM	5.32			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1390402	CHEMBL3391480	B	Inhibition of HDAC-2 (unknown origin) using (FAM)-labeled acetylated peptide as substrate after 17 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		85880	CHEMBL3390834		MedChemComm	2012	3	2	135			
CHEMBL3353053	1817157	CHEMBL3353053	1817157		9a	288.3	.63	79.5	0	Cn1cccc1C(=O)N2CCn3cc(cc3C2)C(=O)NO	14992232	IC50	=	39000	nM	4.41			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1431996	CHEMBL3388101	B	Inhibition of full length C-terminal 6x-His tagged human HDAC2 using Arg-His-Lys-Lys(Ac) substrate incubated for 2 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89845	CHEMBL3351349	25454270	Bioorg. Med. Chem. Lett.	2014	24	23	5450			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	1, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	15126331	Ki	=	7	nM	8.15			1	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	1440125	CHEMBL3382538	B	Inhibition of human recombinant HDAC2 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89689	CHEMBL3351463	25380299	J. Med. Chem.	2014	57	22	9644			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	Trichostatin A	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	14973543	IC50	=	28.2	nM	7.55			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1434457	CHEMBL3388274	B	Inhibition of HDAC2 (unknown origin) after 15 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89860	CHEMBL3352210	25455492	Bioorg. Med. Chem. Lett.	2014	24	23	5497			
CHEMBL14227	13450	CHEMBL14227	13450	BUTANOIC ACID	1	88.11	.92	37.29	0	CCCC(=O)O	5207851	IC50	=	12000	nM	4.92			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	718469	CHEMBL1680133	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	55650	CHEMBL1671826	21874153	ACS Med. Chem. Lett.	2011	2	1	39			
CHEMBL2407730	1572136	CHEMBL2407730	1572136		31	321.33	1.78	100.03	0	ONC(=O)c1ccc(CNc2nccc(n2)c3cccnc3)cc1	13395018	IC50	=	219	nM	6.66			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL3356927	1821070	CHEMBL3356927	1821070		47, ST7543	439.57	2.92	126.1	0	SCCCCC[C@H](NC(=O)[C@H]1[C@H](CNC1=O)c2ccccc2)C(=O)Nc3ccccc3	15138227	IC50	=	168	nM	6.77			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL180911	300856	CHEMBL180911	300856		11	323.45	1.79	100.24	0	CN(C)c1ccc(cc1)C(=O)NCCCCCNC(=O)CS	1902507	IC50	=	6460	nM	5.19			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	439074	CHEMBL889422	B	Inhibition of His-tagged HDAC2 expressed in Sf9 cells by fluorescence-based assay	1	Scientific Literature				Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			36060	CHEMBL1145385	17539623	J. Med. Chem.	2007	50	13	3054	1759	CHEMBL3308860	Sf9
CHEMBL154574	257843	CHEMBL154574	257843		11	163.17	1.31	49.33	0	ONC(=O)\C=C\c1ccccc1	12680991	IC50	=	457	nM	6.34			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	944722	CHEMBL2340968	B	Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772			
CHEMBL356769	239841	CHEMBL356769	239841	TUBACIN	15	721.86	7.18	168.45	2	OCc1ccc(cc1)[C@@H]2C[C@H](CSc3oc(c4ccccc4)c(n3)c5ccccc5)O[C@@H](O2)c6ccc(NC(=O)CCCCCCC(=O)NO)cc6	3390033	Ki	=	42	nM	7.38			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL3427755	1845151	CHEMBL3427755	1845151		3k	271.31	2.57	81	0	COc1ccc(cc1)c2n[nH]c3C(CCCc23)C(=O)N	15255905	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL271102	439215	CHEMBL271102	439215		79a, SB-429201	436.5	5.45	67.43	1	O=C(CCc1ccccc1)Nc2ccc(cc2)C(=O)Nc3ccc(Oc4ccccc4)cc3	2106199	IC50					Not Determined		0	BAO_0000190			464924	CHEMBL946981	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38494	CHEMBL1142268	18247554	J. Med. Chem.	2008	51	6	1505			
CHEMBL1094708	614707	CHEMBL1094708	614707		4l	422.48	2.97	135.16	0	Nc1ccc(cc1)n2cc(nn2)c3cccc(NC(=O)CCCCCCC(=O)NO)c3	3201425	IC50					Not Determined		0	BAO_0000190			616013	CHEMBL1101057	B	Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			50398	CHEMBL1154884	20055418	J. Med. Chem.	2010	53	3	1347			
CHEMBL1834369	1178413	CHEMBL1834369	1178413		TM-2-126	338.35	4.44	73.22	0	FC(F)(F)c1ccc(CNC(=S)NC(=O)c2ccccc2)cc1	6376235	Inhibition	=	7	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	771822	CHEMBL1838694	B	Inhibition of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL2425953	1581072	CHEMBL2425953	1581072		3a	321.33	2.09	82	0	CC1=Nc2cccc(\C=C\C(=O)NO)c2C(=O)N1c3ccccc3	13451930	IC50	>	10000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL227120	382032	CHEMBL227120	382032		5	322.4	1.91	93.7	0	CN(C)c1ccc(NC(=O)NCCCCCCC(=O)NO)cc1	1902513	IC50	=	647	nM	6.19			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	439074	CHEMBL889422	B	Inhibition of His-tagged HDAC2 expressed in Sf9 cells by fluorescence-based assay	1	Scientific Literature				Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			36060	CHEMBL1145385	17539623	J. Med. Chem.	2007	50	13	3054	1759	CHEMBL3308860	Sf9
CHEMBL251009	416381	CHEMBL251009	416381		7a	280.32	1.22	98.66	0	ONC(=O)CCCCCC(O)C(=O)Nc1ccccc1	2049522	IC50	=	500	nM	6.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL2417782	1576546	CHEMBL2417782	1576546		8	462.56	3.64	157.88	0	CC(C)(C)OC(=O)Nc1cccc(c1)c2csc(NC(=O)CCCCCCC(=O)NO)n2	13431366	IC50	=	21	nM	7.68			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	977740	CHEMBL2424287	B	Inhibition of His-6-tagged full length HDAC2 (unknown origin) expressed in sf9 cells using carboxyfluorescein (FAM)-labeled acetylated peptide as substrate after 17 hrs by fluorescence-based electrophoretic assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74749	CHEMBL2417402	23627282	J. Med. Chem.	2013	56	16	6297			
CHEMBL2442698	1589225	CHEMBL2442698	1589225		7c	661.7	4.06	173.91	2	COc1cc(cc(OC)c1O)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](Nc4ccc(NC(=O)CCCCCCC(=O)NO)cc4)c5cc6OCOc6cc25	13502671	IC50	=	140	nM	6.85			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	989630	CHEMBL2445174	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	75370	CHEMBL2439983	24095018	Bioorg. Med. Chem.	2013	21	22	6981			
CHEMBL3098606	1609376	CHEMBL3098606	1609376		30	404.46	.89	136.63	0	Cc1ccc(NC(=O)[C@H](CCCCCC(=O)NO)NC(=O)[C@H]2CCC(=O)N2)cc1	13867798	IC50	=	93	nM	7.03			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL3086767	1604238	CHEMBL3086767	1604238		1, Synthetic SCA, santacruzamate A	278.35	1.9	67.43	0	CCOC(=O)NCCCC(=O)NCCc1ccccc1	13838843	Inhibition					Active		0	BAO_0000376			1276437	CHEMBL3088533	B	Inhibition of human recombinant HDAC2 at 1 uM after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			76042	CHEMBL3085682	24164245	J. Nat. Prod.	2013	76	11	2026			
CHEMBL3086768	1604239	CHEMBL3086768	1604239		3, 1-SAHA hybrid	250.29	.97	78.43	0	ONC(=O)CCCC(=O)NCCc1ccccc1	13838847	Inhibition					Active		0	BAO_0000376			1276437	CHEMBL3088533	B	Inhibition of human recombinant HDAC2 at 1 uM after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			76042	CHEMBL3085682	24164245	J. Nat. Prod.	2013	76	11	2026			
CHEMBL3086768	1604239	CHEMBL3086768	1604239		3, 1-SAHA hybrid	250.29	.97	78.43	0	ONC(=O)CCCC(=O)NCCc1ccccc1	13838873	IC50	=	3.5	nM	8.46			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1276444	CHEMBL3088540	B	Inhibition of human recombinant HDAC2 after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76042	CHEMBL3085682	24164245	J. Nat. Prod.	2013	76	11	2026			
CHEMBL3086767	1604238	CHEMBL3086767	1604238		1, Synthetic SCA, santacruzamate A	278.35	1.9	67.43	0	CCOC(=O)NCCCC(=O)NCCc1ccccc1	13838874	IC50	=	.112	nM	9.95			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1276444	CHEMBL3088540	B	Inhibition of human recombinant HDAC2 after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76042	CHEMBL3085682	24164245	J. Nat. Prod.	2013	76	11	2026			
CHEMBL556532	559430	CHEMBL556532	559430		1a	239.27	2.83	49.33	0	ONC(=O)\C=C\c1ccc(cc1)c2ccccc2	14570735	IC50	=	820	nM	6.09			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1335247	CHEMBL3238600	B	Inhibition of HDAC2 in human HeLa cells using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82343	CHEMBL3232764	24742384	Eur. J. Med. Chem.	2014	79		251			
CHEMBL3309284	1778372	CHEMBL3309284	1778372		27	345.39	1.47	98.73	0	CN1C(=O)C=Cc2cc(ccc12)C(=O)NCCCCCCC(=O)NO	15053558	IC50	=	90	nM	7.05			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1450057	CHEMBL3373319	B	Inhibition of human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90190	CHEMBL3351757	24864038	Bioorg. Med. Chem.	2014	22	14	3720			
CHEMBL3309300	1778388	CHEMBL3309300	1778388		43	401.5	2.4	107.52	0	CC1(C)CC(=O)Nc2ccc(cc12)C(=O)NC[C@@H]3CC[C@H](CCC(=O)NO)CC3	15053566	IC50	=	25	nM	7.6			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1450057	CHEMBL3373319	B	Inhibition of human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90190	CHEMBL3351757	24864038	Bioorg. Med. Chem.	2014	22	14	3720			
CHEMBL3317815	1782454	CHEMBL3317815	1782454		8	511.68	.87	228.11	1	C[C@@]12CSC(=N1)c3csc(CNC(=O)C[C@H](OC(=O)[C@H](CCCN)NC2=O)\C=C\CCS)n3	15060231	IC50	=	6.3	nM	8.2			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1452234	CHEMBL3366146	B	Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90621	CHEMBL3352389	25070421	Bioorg. Med. Chem. Lett.	2014	24	16	3728			
CHEMBL3329622	1788610	CHEMBL3329622	1788610		5	772.03	4.57	278.52	2	CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c3csc(CNC(=O)C[C@H](OC1=O)\C=C\CCSSC[C@H](NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)n3	15136619	IC50	=	.9	nM	9.05			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1455096	CHEMBL3366352	B	Inhibition of HDAC2 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90823	CHEMBL3352121	25147612	ACS Med. Chem. Lett.	2014	5	8	905			
CHEMBL483495	508155	CHEMBL483495	508155		6d	530.41	3.96	129.37	1	ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)c2cn(CC(O)c3cccc(Br)c3)nn2	2351866	IC50	=	143	nM	6.84			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL471042	521234	CHEMBL471042	521234		12, ST2987	341.32	2.66	116.73	0	ONC(=O)\C=C\c1ccc(\C=N\OCc2ccc(cc2)[N+](=O)[O-])cc1	2409598	IC50	=	2670	nM	5.57			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	565674	CHEMBL960032	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46441	CHEMBL1153969	19285395	Bioorg. Med. Chem. Lett.	2009	19	8	2346			
CHEMBL1496179	920063	CHEMBL1496179	920063		TM-2-139	288.34	3.7	73.22	0	Fc1ccccc1C(=O)NC(=S)NCc2ccccc2	6376230	Inhibition					Not Active		0	BAO_0000376			771822	CHEMBL1838694	B	Inhibition of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1496179	920063	CHEMBL1496179	920063		TM-2-139	288.34	3.7	73.22	0	Fc1ccccc1C(=O)NC(=S)NCc2ccccc2	6377078	Activity					Not Active		0	BAO_0000375			771836	CHEMBL1838708	B	Activation of HDAC2 using Fluor-de-Lys as substrate at 10 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1496179	920063	CHEMBL1496179	920063		TM-2-139	288.34	3.7	73.22	0	Fc1ccccc1C(=O)NC(=S)NCc2ccccc2	6376318	Activity					Not Active		0	BAO_0000375			771829	CHEMBL1838701	B	Activation of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL3233687	1732192	CHEMBL3233687	1732192		11e	455.51	4.38	103.45	0	ONC(=O)\C=C\c1ccc(OC[C@H](Cc2c[nH]c3ccccc23)NC(=O)c4ccccc4)cc1	14573362	Inhibition					Active		0	BAO_0000376			1337867	CHEMBL3240894	B	Inhibition of HDAC2 in human U937 cells assessed as increase of intracellular acetylated histone H3 level at 1 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			82316	CHEMBL3232921	24694055	J. Med. Chem.	2014	57	8	3324			
CHEMBL3233687	1732192	CHEMBL3233687	1732192		11e	455.51	4.38	103.45	0	ONC(=O)\C=C\c1ccc(OC[C@H](Cc2c[nH]c3ccccc23)NC(=O)c4ccccc4)cc1	14570586	IC50	=	535.5	nM	6.27			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1337840	CHEMBL3240668	B	Inhibition of HDAC2 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82316	CHEMBL3232921	24694055	J. Med. Chem.	2014	57	8	3324			
CHEMBL141909	231664	CHEMBL141909	231664		TWZ 107	328.41	3.25	69.64	0	ON(CCCCCCCC(=O)Nc1ccc2ccccc2c1)C=O	1275490	IC50	=	890	nM	6.05			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	87875	CHEMBL697297	B	Inhibition of Histone deacetylase 2 (HDAC2) activity of HeLa nuclear extracts	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	6553	CHEMBL1137945	14698179	Bioorg. Med. Chem. Lett.	2004	14	2	449			
CHEMBL1088736	614583	CHEMBL1088736	614583		4g	467.52	2.5	149.6	0	OCc1cc(CO)cc(c1)n2cc(nn2)c3cccc(NC(=O)CCCCCCC(=O)NO)c3	3201394	IC50	=	27.8	nM	7.56			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	616013	CHEMBL1101057	B	Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			50398	CHEMBL1154884	20055418	J. Med. Chem.	2010	53	3	1347			
CHEMBL1213490	685334	CHEMBL1213490	685334	ROMIDEPSIN	2, FK-228	541.72	2.26	208.27	1	C\C=C\1/NC(=O)[C@@H](CS)NC(=O)[C@H](CC(=O)C[C@H](OC(=O)[C@@H](NC1=O)C(C)C)\C=C\CCS)C(C)C	3389934	Ki	=	.038	nM	10.42			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL2407734	1572140	CHEMBL2407734	1572140		13a	455.51	2.75	116.88	0	CC(=O)N1C(Cc2ccccc2)C(=O)N=C1NCc3ccc(cc3)C(=O)Nc4ccccc4N	13395014	IC50	=	260	nM	6.59			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL408513	435188	CHEMBL408513	435188	BELINOSTAT	PXD101	318.35	1.8	103.88	0	ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)Nc2ccccc2	6370664	Ki	=	22	nM	7.66			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	769058	CHEMBL1832521	B	Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58940	CHEMBL1828590	21634430	J. Med. Chem.	2011	54	13	4694			
CHEMBL1800379	1161443	CHEMBL1800379	1161443		26	266.34	2.9	116.61	0	Cc1cc(O)nc(SCC(=O)c2cccs2)n1	6283049	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL1914702	1262141	CHEMBL1914702	1262141		2b	546.54	4.71	233.05	1	ONC(=O)CCCCCCNC(=O)c1cc(on1)c2ccc(NC(=O)c3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2	7921739	IC50	=	780	nM	6.11			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	785884	CHEMBL1921153	B	Inhibition of human recombinant HDAC2 using fluorophore-conjugated substrate Boc-L-Lys(Ac)-AMC after 60 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	60081	CHEMBL1914352	21548582	J. Med. Chem.	2011	54	13	4350			
CHEMBL1914702	1262141	CHEMBL1914702	1262141		2b	546.54	4.71	233.05	1	ONC(=O)CCCCCCNC(=O)c1cc(on1)c2ccc(NC(=O)c3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2	7921766	Ratio IC50	=	11.5					0	BAO_0000179			785760	CHEMBL1920780	B	Selectivity ratio of compound IC50 to TSA IC50 for human recombinant HDAC2 using fluorophore-conjugated substrate Boc-L-Lys(Ac)-AMC after 60 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			60081	CHEMBL1914352	21548582	J. Med. Chem.	2011	54	13	4350			
CHEMBL1914702	1262141	CHEMBL1914702	1262141		2b	546.54	4.71	233.05	1	ONC(=O)CCCCCCNC(=O)c1cc(on1)c2ccc(NC(=O)c3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2	7921784	Ratio IC50	=	7.8					0	BAO_0000179			785751	CHEMBL1920771	B	Selectivity ratio of compound IC50 to SAHA IC50 for human recombinant HDAC2 using fluorophore-conjugated substrate Boc-L-Lys(Ac)-AMC after 60 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			60081	CHEMBL1914352	21548582	J. Med. Chem.	2011	54	13	4350			
CHEMBL1957459	1282990	CHEMBL1957459	1282990		8c	449.57	2.63	118.93	0	CN1CCN(CC1)C(=O)NCc2ccc(cc2)C(=O)Nc3cc(ccc3N)c4cccs4	8048589	IC50	=	800	nM	6.1			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	807676	CHEMBL1959441	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			61262	CHEMBL1955769	22321215	Bioorg. Med. Chem. Lett.	2012	22	5	1926			
CHEMBL1801238	1162311	CHEMBL1801238	1162311		21f	359.81	1.19	90.38	0	ONC(=O)c1cnc(nc1)N2C[C@@H]3[C@H](C2)[C@H]3NCc4ccc(Cl)cc4	6273618	IC50	=	14	nM	7.85			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	755404	CHEMBL1804720	B	Inhibition of human recombinant HDAC2 using fluor de Lys as substrate by fluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	58134	CHEMBL1800056	21080647	J. Med. Chem.	2010	53	24	8663			
CHEMBL1487	417180	CHEMBL1487	417180	ATORVASTATIN	atorvastatin	558.64	5.56	111.79	2	CC(C)c1c(C(=O)Nc2ccccc2)c(c3ccccc3)c(c4ccc(F)cc4)n1CC[C@@H](O)C[C@@H](O)CC(=O)O	12718189	IC50	=	22547	nM	4.65			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	950484	CHEMBL2351477	B	Inhibition of recombinant HDAC2 (unknown origin) after 10 mins by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72873	CHEMBL2346500	23570542	J. Med. Chem.	2013	56	9	3645			
CHEMBL2407741	1572147	CHEMBL2407741	1572147		8c	475.34	3.55	105.82	0	Nc1cc(Br)ccc1NC(=O)c2ccc(CNc3nccc(n3)c4cccnc4)cc2	13395025	IC50	>	20000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL3427758	1845154	CHEMBL3427758	1845154		3n	326.21	3.28	100.01	0	NC(=O)C1CCCc2c1[nH]nc2c3cc(Br)cs3	15255908	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL1097651	626206	CHEMBL1097651	626206		12	278.31	2.78	68.26	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3occc3	3286435	Ratio IC50	=	42					0	BAO_0000179			630933	CHEMBL1116532	B	Selectivity ratio of IC50 for human recombinant HDAC2 preincubated for 1 hr with substrate to IC50 for human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1097651	626206	CHEMBL1097651	626206		12	278.31	2.78	68.26	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3occc3	3286382	IC50	=	43	nM	7.37			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1097651	626206	CHEMBL1097651	626206		12	278.31	2.78	68.26	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3occc3	3286402	IC50	=	1800	nM	5.74			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL250005	416401	CHEMBL250005	416401		7m	430.49	3.18	106.12	0	COc1ccc(COC(CCCCCC(=O)NO)C(=O)Nc2ccc(OC)cc2)cc1	2049599	Activity					Not Active		0	BAO_0000375			458150	CHEMBL925483	B	Inhibition of HDAC2 in HeLa cell lysates at 0.1 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	1613701	IC50	=	39	nM	7.41			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	321268	CHEMBL881893	B	Inhibitory concentration against histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	30039	CHEMBL1142838	16137884	Bioorg. Med. Chem. Lett.	2005	15	20	4427			
CHEMBL139193	232024	CHEMBL139193	232024		TWZ 105	264.32	1.88	69.64	0	ON(CCCCCCC(=O)Nc1ccccc1)C=O	1282958	IC50	=	11000	nM	4.96			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	87875	CHEMBL697297	B	Inhibition of Histone deacetylase 2 (HDAC2) activity of HeLa nuclear extracts	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	6553	CHEMBL1137945	14698179	Bioorg. Med. Chem. Lett.	2004	14	2	449			
CHEMBL227170	382035	CHEMBL227170	382035		9	518.6	3.48	153.78	2	N[C@@H](Cc1ccc(O)cc1)C(=O)Nc2ccccc2c3ccc(NC(=O)CCCCCCC(=O)NO)cc3	1902509	IC50	=	205	nM	6.69			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	439074	CHEMBL889422	B	Inhibition of His-tagged HDAC2 expressed in Sf9 cells by fluorescence-based assay	1	Scientific Literature				Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			36060	CHEMBL1145385	17539623	J. Med. Chem.	2007	50	13	3054	1759	CHEMBL3308860	Sf9
CHEMBL248998	416397	CHEMBL248998	416397		7j	430.49	3.18	106.12	0	COc1cc(COC(CCCCCC(=O)NO)C(=O)Nc2ccccc2)cc(OC)c1	2049527	IC50	>=	50	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL248590	416387	CHEMBL248590	416387		17	400.47	3.19	96.89	0	COc1ccc(CO[C@H](CCCCCC(=O)NO)C(=O)Nc2ccccc2)cc1	2049532	IC50	>=	50	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL393242	399343	CHEMBL393242	399343		21	346.41	2.8	109.14	0	Nc1ccc(cc1NC(=O)c2ccc3nccnc3c2)c4cccs4	1998285	IC50	=	200	nM	6.7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL1164992	645852	CHEMBL1164992	645852	TRICIFEROL	4	429.59	4.17	89.79	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)[C@H]1CC[C@H]2\C(=C\C=C/3\C[C@H](O)C[C@H](O)C3)\CCC[C@]12C	3341233	IC50	=	10400	nM	4.98			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	639020	CHEMBL1166158	B	Inhibition of HDAC2 after 10 mins by fluorometric assay	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51523	CHEMBL1165922	20452225	Bioorg. Med. Chem.	2010	18	11	4119			
CHEMBL1165293	645982	CHEMBL1165293	645982		23b	494.71	5.22	95.58	1	C[C@H](CCCCC(=O)Nc1ccccc1N)[C@H]2CC[C@H]3\C(=C\C=C4C[C@@H](O)C[C@H](O)C4)\CCC[C@]23C	3341235	IC50	=	189000	nM			Outside typical range	0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	639020	CHEMBL1166158	B	Inhibition of HDAC2 after 10 mins by fluorometric assay	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51523	CHEMBL1165922	20452225	Bioorg. Med. Chem.	2010	18	11	4119			
CHEMBL1164244	645338	CHEMBL1164244	645338		30b	445.63	4.26	86.63	0	CNC(=O)C(=O)CCCC[C@@H](C)[C@H]1CC[C@H]2\C(=C\C=C3C[C@@H](O)C[C@H](O)C3)\CCC[C@]12C	3341237	IC50	=	90400	nM	4.04			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	639020	CHEMBL1166158	B	Inhibition of HDAC2 after 10 mins by fluorometric assay	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51523	CHEMBL1165922	20452225	Bioorg. Med. Chem.	2010	18	11	4119			
CHEMBL2170019	1429498	CHEMBL2170019	1429498		9	666.85	2.43	193.57	2	CCC(=O)CCCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)CCN(CC(C)C)C(=O)CN(CCc2c[nH]c3ccccc23)C1=O	12103872	IC50	=	300	nM	6.52			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	861541	CHEMBL2174389	B	Inhibition of human recombinant HDAC2 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	65900	CHEMBL2169795		ACS Med. Chem. Lett.	2012	3	9	749			
CHEMBL2152613	1423292	CHEMBL2152613	1423292		33a	332.4	4.27	64.35	0	NC(=O)c1ccccc1Nc2cccc(OCCc3ccccc3)c2	12064405	IC50	>	30000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	851448	CHEMBL2156454	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			65400	CHEMBL2150931	22642300	J. Med. Chem.	2012	55	12	5760			
CHEMBL2178342	1439136	CHEMBL2178342	1439136		C149	326.37	3.15	105.34	0	ONC(=O)c1cccc(c1)c2cn(CSc3ccccc3)nn2	12148684	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	878901	CHEMBL2185052	B	Inhibition of HDAC2 by fluorometric assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			66685	CHEMBL2176939	23116147	J. Med. Chem.	2012	55	22	9562			
CHEMBL2170177	1429658	CHEMBL2170177	1429658		6, PCI-34051	296.32	2.91	63.48	0	COc1ccc(Cn2ccc3ccc(cc23)C(=O)NO)cc1	12148688	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	878901	CHEMBL2185052	B	Inhibition of HDAC2 by fluorometric assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			66685	CHEMBL2176939	23116147	J. Med. Chem.	2012	55	22	9562			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	2	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	12148689	IC50	=	780	nM	6.11			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	878901	CHEMBL2185052	B	Inhibition of HDAC2 by fluorometric assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			66685	CHEMBL2176939	23116147	J. Med. Chem.	2012	55	22	9562			
CHEMBL2179618	1440425	CHEMBL2179618	1440425	NEXTURASTAT A	5g, Nexturastat A	341.4	3.08	81.67	0	CCCCN(Cc1ccc(cc1)C(=O)NO)C(=O)Nc2ccccc2	12143994	IC50	=	6920	nM	5.16			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	875956	CHEMBL2188462	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			66616	CHEMBL2176914	23009203	J. Med. Chem.	2012	55	22	9891			
CHEMBL1800246	1161309	CHEMBL1800246	1161309		12	301.3	1.51	101.41	0	CC(=O)Nc1ccc(cc1)C(=O)COc2nc(C)cc(O)n2	6283035	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL2178223	1439016	CHEMBL2178223	1439016		51	533.06	3.82	107.69	1	CC(C)(O)CN1C[C@@H]([C@H](C1)c2ccc(\C=C\C(=O)Nc3ccccc3N)cc2)C(=O)Nc4ccc(Cl)cc4	12136058	IC50					Not Determined		0	BAO_0000190			874014	CHEMBL2186139	B	Inhibition of HDAC2 using p53 (379 to 382 residues) based fluorogenic peptide substrate	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			66641	CHEMBL2177000	23061376	J. Med. Chem.	2012	55	20	8903			
CHEMBL483254	499179	CHEMBL483254	499179	PANOBINOSTAT	LBH-589	349.43	3.19	77.15	0	Cc1[nH]c2ccccc2c1CCNCc3ccc(\C=C\C(=O)NO)cc3	13297579	IC50	<	300	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	958899	CHEMBL2384807	B	Inhibition of HDAC2 (unknown origin) after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			73668	CHEMBL2380312	23672185	J. Med. Chem.	2013	56	11	4816			
CHEMBL2425967	1581086	CHEMBL2425967	1581086		4a	381.4	3.29	82	0	CCC1=Nc2cc(\C=C\C(=O)NO)c(F)cc2C(=O)N1CCc3ccccc3	13451914	IC50	>	10000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL2425963	1581082	CHEMBL2425963	1581082		3k	375.42	3.18	82	0	ONC(=O)\C=C\c1ccc2C(=O)N(CCc3ccccc3)C(=Nc2c1)C4CC4	13451918	IC50					Not Determined		0	BAO_0000190			983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL2407737	1572143	CHEMBL2407737	1572143		30b	472.62	5.71	133.87	1	Nc1ccccc1NC(=O)c2ccc(CSC3=N[C@@H](Cc4c[nH]c5ccccc45)CS3)cc2	13395011	IC50	=	920	nM	6.04			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL2407732	1572138	CHEMBL2407732	1572138		13b	494.54	3.05	132.67	0	CC(=O)N1C(Cc2c[nH]c3ccccc23)C(=O)N=C1NCc4ccc(cc4)C(=O)Nc5ccccc5N	13395016	IC50	=	116	nM	6.94			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL178456	301032	CHEMBL178456	301032		4	331.43	1.98	109.89	0	SCC(=O)NCCCCCC(=O)Nc1cccc2cccnc12	13431388	IC50	=	1250	nM	5.9			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	977749	CHEMBL2424296	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74749	CHEMBL2417402	23627282	J. Med. Chem.	2013	56	16	6297			
CHEMBL272980	434834	CHEMBL272980	434834	MOCETINOSTAT	MGCD0103, Mocetinostat	396.44	2.8	105.82	0	Nc1ccccc1NC(=O)c2ccc(CNc3nccc(n3)c4cccnc4)cc2	13394009	IC50	=	22	nM	7.66			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL2436594	1585745	CHEMBL2436594	1585745		12	606.8	4.61	190.56	1	CCCCCCCC(=O)SCC\C=C\[C@@H]1CC(=O)NCc2occ(n2)C3=N[C@@](C)(CS3)C(=O)N[C@@H](C(C)C)C(=O)O1	13472699	IC50	=	2100	nM	5.68			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	988355	CHEMBL2437618	B	Inhibition of HDAC2 (unknown origin) using MAZ1600 and MAZ1675 as substrate assessed as fluorogenic release of 7-amino-4-methylcoumarin from substrate by optimized homogenous assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	75140	CHEMBL2434914	24035339	Bioorg. Med. Chem. Lett.	2013	23	21	6025			
CHEMBL27759	36237	CHEMBL27759	36237	ENTINOSTAT	MS-275	376.41	2.07	106.33	0	Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2	13297578	IC50	<	300	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	958899	CHEMBL2384807	B	Inhibition of HDAC2 (unknown origin) after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			73668	CHEMBL2380312	23672185	J. Med. Chem.	2013	56	11	4816			
CHEMBL2425970	1581089	CHEMBL2425970	1581089		5a	427.5	4.6	82	0	CCC1=Nc2ccc(Cc3ccc(cc3)C(=O)NO)cc2C(=O)N1CCc4ccccc4	13451911	IC50	=	3610	nM	5.44			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL2018302	1336035	CHEMBL2018302	1336035	TUBASTATIN A	tubustatin A	335.4	3.08	57.5	0	CN1CCc2c(C1)c3ccccc3n2Cc4ccc(cc4)C(=O)NO	13451925	IC50	>	30000	nM				1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL2407739	1572145	CHEMBL2407739	1572145		8a	446.5	3.71	105.82	0	Nc1cc2ccccc2cc1NC(=O)c3ccc(CNc4nccc(n4)c5cccnc5)cc3	13395027	IC50	>	20000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL2441614	1588130	CHEMBL3040723	1593534		2, NO-MS275	542.55	-.42	184.86	1	CN(Cc1ccc(COC(=O)NCc2ccc(cc2)C(=O)Nc3ccccc3N)cn1)Cc4no[n+]([O-])c4C#N.CS(=O)(=O)O	13492739	Activity					Not Active		0	BAO_0000375			991422	CHEMBL2444402	B	Induction of HDAC2 cysteine S-nitrosylation in human HaCaT cells at 10 uM after 1 hr by immunoprecipitation method in prsence of NO scavenger PTIO	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75273	CHEMBL2440104		ACS Med. Chem. Lett.	2013	4	10	994			
CHEMBL2441614	1588130	CHEMBL3040723	1593534		2, NO-MS275	542.55	-.42	184.86	1	CN(Cc1ccc(COC(=O)NCc2ccc(cc2)C(=O)Nc3ccccc3N)cn1)Cc4no[n+]([O-])c4C#N.CS(=O)(=O)O	13492740	Activity					Active		0	BAO_0000375			991423	CHEMBL2444403	B	Induction of HDAC2 cysteine S-nitrosylation in human HaCaT cells at 10 uM after 1 hr by immunoprecipitation method	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75273	CHEMBL2440104		ACS Med. Chem. Lett.	2013	4	10	994			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	13488693	Inhibition					Active		0	BAO_0000376			987733	CHEMBL2439711	B	Inhibition of HDAC2 (unknown origin)-mediated deacetylation at 10 uM preincubated for 5 mins prior to substrate addition measured after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75182	CHEMBL2434956	24074025	J. Med. Chem.	2013	56	20	7997			
CHEMBL2387320	1564095	CHEMBL2387320	1564095		3	1305.19				OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3CO)O[C@H]4[C@H](O)[C@@H](O)[C@H](O[C@@H]4CO)O[C@H]5[C@H](O)[C@@H](O)[C@H](O[C@@H]5CO)O[C@H]6[C@H](O)[C@@H](O)[C@H](O[C@@H]6CNC(=O)CCCCCCC(=O)NO)O[C@H]7[C@H](O)[C@@H](O)[C@H](O[C@@H]7CO)O[C@H]8[C@H](O)[C@@H](O)[C@H](O[C@@H]8CO)O[C@H]1[C@H](O)[C@H]2O	13331206	IC50	=	1200	nM	5.92			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	961399	CHEMBL2387804	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	73722	CHEMBL2384983	23591111	Bioorg. Med. Chem. Lett.	2013	23	11	3346			
CHEMBL3098605	1609375	CHEMBL3098605	1609375		34	278.35	2.49	78.43	0	Cc1ccc(NC(=O)CCCCCCC(=O)NO)cc1	13867799	IC50	=	589	nM	6.23			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	14570723	IC50	=	100	nM	7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1335247	CHEMBL3238600	B	Inhibition of HDAC2 in human HeLa cells using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82343	CHEMBL3232764	24742384	Eur. J. Med. Chem.	2014	79		251			
CHEMBL3235464	1733987	CHEMBL3235464	1733987		2c, ST3056	403.51	5.22	58.56	1	COc1ccc(cc1C23CC4CC(CC(C4)C2)C3)c5ccc(\C=C\C(=O)NO)cc5	14570781	IC50	=	2300	nM	5.64			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1335247	CHEMBL3238600	B	Inhibition of HDAC2 in human HeLa cells using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82343	CHEMBL3232764	24742384	Eur. J. Med. Chem.	2014	79		251			
CHEMBL3356916	1821059	CHEMBL3356916	1821059		129, ST8001	391.53	2.53	126.1	0	Cc1cccc(NC(=O)[C@H](CCCCCS)NC(=O)[C@@H]2CCCC(=O)N2)c1	15138239	IC50	=	15	nM	7.82			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3356523	1820662	CHEMBL3356523	1820662		127, ST7538	377.5	2.04	126.1	0	SCCCCC[C@H](NC(=O)[C@@H]1CCCC(=O)N1)C(=O)Nc2ccccc2	15138244	IC50	=	67	nM	7.17			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3317814	1782453	CHEMBL3317814	1782453		7	497.65	.29	228.11	0	C[C@@]12CSC(=N1)c3csc(CNC(=O)C[C@H](OC(=O)[C@H](CCN)NC2=O)\C=C\CCS)n3	15060215	IC50	=	21	nM	7.68			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1452234	CHEMBL3366146	B	Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90621	CHEMBL3352389	25070421	Bioorg. Med. Chem. Lett.	2014	24	16	3728			
CHEMBL593229	593690	CHEMBL593229	593690	AUREUSIDIN	36	286.24	2.17	107.22	0	Oc1cc(O)c2C(=O)\C(=C\c3ccc(O)c(O)c3)\Oc2c1	14973542	IC50	=	38900	nM	4.41			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1434457	CHEMBL3388274	B	Inhibition of HDAC2 (unknown origin) after 15 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89860	CHEMBL3352210	25455492	Bioorg. Med. Chem. Lett.	2014	24	23	5497			
CHEMBL3426803	1844189	CHEMBL3426803	1844189		1, MC1742	395.47	3.61	116.09	0	ONC(=O)CCCCSC1=NC(=CC(=O)N1)c2ccc(cc2)c3ccccc3	15248545	IC50	=	110	nM	6.96			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1478435	CHEMBL3429373	B	Inhibition of recombinant HDAC2 (unknown origin) by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91811	CHEMBL3425488	25905694	J. Med. Chem.	2015	58	9	4073			
CHEMBL483254	499179	CHEMBL483254	499179	PANOBINOSTAT	LBH, LBH589	349.43	3.19	77.15	0	Cc1[nH]c2ccccc2c1CCNCc3ccc(\C=C\C(=O)NO)cc3	14573454	Inhibition					Active		0	BAO_0000376			1337867	CHEMBL3240894	B	Inhibition of HDAC2 in human U937 cells assessed as increase of intracellular acetylated histone H3 level at 1 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			82316	CHEMBL3232921	24694055	J. Med. Chem.	2014	57	8	3324			
CHEMBL226817	377845	CHEMBL1182267	656217		10b	518.86	12.65	7.76	2	[Cl-].[I-].C=CCCCCCC[n+]1cccc(CCCCCCCCCCCC[n+]2cccc(CCCCC=C)c2)c1	1861904	Activity					Not Active		0	BAO_0000375			434815	CHEMBL917043	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			35656	CHEMBL1139873	17447750	J. Med. Chem.	2007	50	10	2497			
CHEMBL3417215	1840423	CHEMBL3417215	1840423		11c	581.66	4.08	121.14	1	COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NCc4cccc(c4)C(=O)Nc5ccccc5N	15218880	IC50	>	20	ug.mL-1				0	BAO_0000190	UO_0000274	http://www.openphacts.org/units/MicrogramPerMilliliter	1471124	CHEMBL3421014	B	Inhibition of recombinant human HDAC2 expressed in baculovirus infected insect High5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91571	CHEMBL3414494	25805446	Eur. J. Med. Chem.	2015	95		127			
CHEMBL27759	36237	CHEMBL27759	36237	ENTINOSTAT	MS-275	376.41	2.07	106.33	0	Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2	15234985	IC50	=	650	nM	6.19			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL3356936	1821079	CHEMBL3356936	1821079		20, ST7807	279.44	4	67.9	0	Cc1cccc(CCNC(=O)CCCCCCS)c1	15138291	IC50	=	10700	nM	4.97			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3311466	1780576	CHEMBL3311466	1780576		14	361.44	1.91	107.53	0	CC1(C)CC(=O)Nc2ccc(NC(=O)CCCCCCC(=O)NO)cc12	15053554	IC50	=	10	nM	8			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1450057	CHEMBL3373319	B	Inhibition of human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90190	CHEMBL3351757	24864038	Bioorg. Med. Chem.	2014	22	14	3720			
CHEMBL3427753	1845149	CHEMBL3427753	1845149		3i	259.28	2.79	71.77	0	NC(=O)C1CCCc2c1[nH]nc2c3ccc(F)cc3	15255903	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL3427771	1845167	CHEMBL3427771	1845167		13b	338.23	4.37	71.77	0	CC1(C)CC(C(=O)N)c2[nH]nc(c2C1)c3ccc(Cl)c(Cl)c3	15255998	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL178456	301032	CHEMBL178456	301032		2	331.43	1.98	109.89	0	SCC(=O)NCCCCCC(=O)Nc1cccc2cccnc12	1902516	IC50	=	7380	nM	5.13			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	439074	CHEMBL889422	B	Inhibition of His-tagged HDAC2 expressed in Sf9 cells by fluorescence-based assay	1	Scientific Literature				Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			36060	CHEMBL1145385	17539623	J. Med. Chem.	2007	50	13	3054	1759	CHEMBL3308860	Sf9
CHEMBL565140	555984	CHEMBL565140	555984		3m	289.71	3.25	69.56	0	ONC(=O)\C=C\c1ccc(cc1)c2ccc(O)c(Cl)c2	2657753	IC50	=	460	nM	6.34			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL356066	234707	CHEMBL356066	234707	DACINOSTAT	12, LAQ-824	379.45	3.05	88.59	0	OCCN(CCc1c[nH]c2ccccc12)Cc3ccc(\C=C\C(=O)NO)cc3	3389956	Ki	=	1.4	nM	8.85			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL272980	434834	CHEMBL272980	434834	MOCETINOSTAT	MGCD0103	396.44	2.8	105.82	0	Nc1ccccc1NC(=O)c2ccc(CNc3nccc(n3)c4cccnc4)cc2	13502672	IC50	=	280	nM	6.55			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	989630	CHEMBL2445174	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	75370	CHEMBL2439983	24095018	Bioorg. Med. Chem.	2013	21	22	6981			
CHEMBL1830424	1177130	CHEMBL1830424	1177130		10s	358.48	3.93	70.39	0	CCCCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(C)C	6370659	Ki	=	21	nM	7.68			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	769058	CHEMBL1832521	B	Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58940	CHEMBL1828590	21634430	J. Med. Chem.	2011	54	13	4694			
CHEMBL3421749	1841185	CHEMBL3421749	1841185		11c	354.36	1.53	109.51	0	COc1ccc(cc1)c2noc(CNCc3ccc(cc3)C(=O)NO)n2	15234978	IC50	>	10000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL440018	301132	CHEMBL440018	301132		7	337.48	2.25	100.24	0	CN(C)c1ccc(cc1)C(=O)NCCCCCCNC(=O)CS	1902511	IC50	=	4640	nM	5.33			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	439074	CHEMBL889422	B	Inhibition of His-tagged HDAC2 expressed in Sf9 cells by fluorescence-based assay	1	Scientific Literature				Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			36060	CHEMBL1145385	17539623	J. Med. Chem.	2007	50	13	3054	1759	CHEMBL3308860	Sf9
CHEMBL2177587	1438373	CHEMBL2177587	1438373		5	474.98	3.78	87.46	0	CN1C[C@@H]([C@H](C1)c2ccc(\C=C\C(=O)Nc3ccccc3N)cc2)C(=O)Nc4ccc(Cl)cc4	12136060	IC50	=	250	nM	6.6			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	874014	CHEMBL2186139	B	Inhibition of HDAC2 using p53 (379 to 382 residues) based fluorogenic peptide substrate	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			66641	CHEMBL2177000	23061376	J. Med. Chem.	2012	55	20	8903			
CHEMBL3427760	1845156	CHEMBL3427760	1845156		3p	281.31	3.18	84.91	0	NC(=O)C1CCCc2c1[nH]nc2c3oc4ccccc4c3	15255972	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL1094710	614709	CHEMBL1094710	614709		11b	413.51	4.17	109.14	0	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)n2cc(nn2)C3CCCCC3	3201403	IC50	=	48.2	nM	7.32			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	616013	CHEMBL1101057	B	Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			50398	CHEMBL1154884	20055418	J. Med. Chem.	2010	53	3	1347			
CHEMBL3421751	1841187	CHEMBL3421751	1841187		11e	358.78	2.21	100.28	0	ONC(=O)c1ccc(CNCc2onc(n2)c3ccc(Cl)cc3)cc1	15234980	IC50	=	8520	nM	5.07			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL1796689	1159741	CHEMBL1796689	1159741	LARGAZOLE THIOL	2	496.67	2.25	202.09	0	CC(C)[C@H]1NC(=O)[C@]2(C)CSC(=N2)c3csc(CNC(=O)C[C@H](OC1=O)\C=C\CCS)n3	15136623	IC50	=	.9	nM	9.05			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1455084	CHEMBL3366340	B	Inhibition of HDAC2 (unknown origin) incubated for 30 mins in presence of BSA and in absence of DTT by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90823	CHEMBL3352121	25147612	ACS Med. Chem. Lett.	2014	5	8	905			
CHEMBL235210	399345	CHEMBL235210	399345		23	324.4	3.32	92.59	0	COc1ccc(cc1)C(=O)Nc2cc(ccc2N)c3cccs3	1998283	IC50	=	200	nM	6.7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL251009	416381	CHEMBL251009	416381		7a	280.32	1.22	98.66	0	ONC(=O)CCCCCC(O)C(=O)Nc1ccccc1	2049604	Activity					Not Active		0	BAO_0000375			458150	CHEMBL925483	B	Inhibition of HDAC2 in HeLa cell lysates at 0.1 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL138626	232022	CHEMBL138626	232022		TWZ 103	292.37	2.42	69.64	0	CC(=O)N(O)CCCCCCCC(=O)Nc1ccccc1	1266088	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	87875	CHEMBL697297	B	Inhibition of Histone deacetylase 2 (HDAC2) activity of HeLa nuclear extracts	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			6553	CHEMBL1137945	14698179	Bioorg. Med. Chem. Lett.	2004	14	2	449			
CHEMBL336935	232370	CHEMBL336935	232370		TWZ 113	485.53	3.02	124.52	0	ON(CCCCCC(C(=O)Nc1ccc2ncccc2c1)C(=O)Nc3ccc4ncccc4c3)C=O	1270389	IC50	=	270	nM	6.57			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	87875	CHEMBL697297	B	Inhibition of Histone deacetylase 2 (HDAC2) activity of HeLa nuclear extracts	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	6553	CHEMBL1137945	14698179	Bioorg. Med. Chem. Lett.	2004	14	2	449			
CHEMBL405072	435637	CHEMBL405072	435637		53	212.25	1.87	55.12	0	Nc1ccccc1NC(=O)c2ccccc2	2099177	IC50	=	3300	nM	5.48			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	468835	CHEMBL947922	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38804	CHEMBL1143185	18182289	Bioorg. Med. Chem. Lett.	2008	18	3	973			
CHEMBL471043	521235	CHEMBL471043	521235		13, ST3049	354.36	2.62	97.22	0	COC(=O)c1ccc(CO\N=C\c2ccc(\C=C\C(=O)NO)cc2)cc1	2409609	IC50	=	15800	nM	4.8			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	565674	CHEMBL960032	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46441	CHEMBL1153969	19285395	Bioorg. Med. Chem. Lett.	2009	19	8	2346			
CHEMBL405072	435637	CHEMBL405072	435637		3	212.25	1.87	55.12	0	Nc1ccccc1NC(=O)c2ccccc2	3286371	Ratio IC50	=	3					0	BAO_0000179			630933	CHEMBL1116532	B	Selectivity ratio of IC50 for human recombinant HDAC2 preincubated for 1 hr with substrate to IC50 for human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL405072	435637	CHEMBL405072	435637		3	212.25	1.87	55.12	0	Nc1ccccc1NC(=O)c2ccccc2	3286391	IC50	=	3100	nM	5.51			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL405072	435637	CHEMBL405072	435637		3	212.25	1.87	55.12	0	Nc1ccccc1NC(=O)c2ccccc2	3286411	IC50	=	10000	nM	5			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1469	397873	CHEMBL1469	397873	PHENYLBUTANOIC ACID	3	164.2	2.41	37.29	0	OC(=O)CCCc1ccccc1	5207869	IC50	=	65000	nM	4.19			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	718469	CHEMBL1680133	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	55650	CHEMBL1671826	21874153	ACS Med. Chem. Lett.	2011	2	1	39			
CHEMBL109	15217	CHEMBL109	15217	VALPROIC ACID	5	144.21	2.75	37.29	0	CCCC(CCC)C(=O)O	5207887	IC50	=	62000	nM	4.21			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	718469	CHEMBL1680133	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	55650	CHEMBL1671826	21874153	ACS Med. Chem. Lett.	2011	2	1	39			
CHEMBL1800375	1161439	CHEMBL1800375	1161439		21	294.76	3.61	88.38	0	Cc1cc(O)nc(SCC(=O)c2ccc(Cl)cc2)n1	6283044	IC50	=	67000	nM	4.17			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL489332	457990	CHEMBL489332	457990		2c	418.53	4.51	70.39	0	ONC(=O)\C=C\c1ccc2c(c1)nc(CCc3ccccc3)n2CCN4CCCCC4	6370653	Ki	=	39	nM	7.41			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	769058	CHEMBL1832521	B	Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58940	CHEMBL1828590	21634430	J. Med. Chem.	2011	54	13	4694			
CHEMBL2057826	1353581	CHEMBL2057826	1353581		1d	384.39	4.77	154.62	0	Nc1ccc(cc1NC(=O)c2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c3ccccc3	10955022	Activity					Active		0	BAO_0000375			829164	CHEMBL2059986	B	Binding affinity to His-tagged human HDAC2 assessed as decrease in biotinylation of HDAC2 at 25 uM preincubated for 24 hrs measured after 1 hr by Western blot analysis in presence of five-fold molar excess of Trichostatin A	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057826	1353581	CHEMBL2057826	1353581		1d	384.39	4.77	154.62	0	Nc1ccc(cc1NC(=O)c2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c3ccccc3	10955040	Inhibition					Active		0	BAO_0000376			829166	CHEMBL2059988	B	Inhibition of HDAC2 in human MDA-MB-231 cells assessed as inhibition of H4 deacetylation at 50 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025	325	CHEMBL3307960	MDA-MB-231
CHEMBL2057826	1353581	CHEMBL2057826	1353581		1d	384.39	4.77	154.62	0	Nc1ccc(cc1NC(=O)c2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c3ccccc3	10954402	Ratio IC50	=	1.5					0	BAO_0000179			829156	CHEMBL2059978	B	Ratio of IC50 for human HDAC2 preincubated for 3 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057826	1353581	CHEMBL2057826	1353581		1d	384.39	4.77	154.62	0	Nc1ccc(cc1NC(=O)c2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c3ccccc3	10954415	Ratio IC50	=	3.2					0	BAO_0000179			829157	CHEMBL2059979	B	Ratio of IC50 for human HDAC2 preincubated for 24 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057826	1353581	CHEMBL2057826	1353581		1d	384.39	4.77	154.62	0	Nc1ccc(cc1NC(=O)c2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c3ccccc3	10954452	Inhibition					tde		0	BAO_0000376			829163	CHEMBL2059985	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057826	1353581	CHEMBL2057826	1353581		1d	384.39	4.77	154.62	0	Nc1ccc(cc1NC(=O)c2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c3ccccc3	10954272	IC50	=	32000	nM	4.49			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829146	CHEMBL2059968	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 5 mins measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057826	1353581	CHEMBL2057826	1353581		1d	384.39	4.77	154.62	0	Nc1ccc(cc1NC(=O)c2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c3ccccc3	10954285	IC50	=	21000	nM	4.68			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829147	CHEMBL2059969	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 3 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057826	1353581	CHEMBL2057826	1353581		1d	384.39	4.77	154.62	0	Nc1ccc(cc1NC(=O)c2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c3ccccc3	10954298	IC50	=	10000	nM	5			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829148	CHEMBL2059970	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 24 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL3098691	1609462	CHEMBL3098691	1609462		11	390.43	.4	136.63	0	ONC(=O)CCCCC[C@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)Nc2ccccc2	13867810	IC50	=	143	nM	6.84			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL585365	570729	CHEMBL585365	570729		10	241.29	2.79	49.33	0	CC(C(=O)NO)(c1ccccc1)c2ccccc2	2922898	Inhibition					Not Active		0	BAO_0000376			592005	CHEMBL1050120	B	Inhibition of recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus at 20 uM after 10 mins by fluorimetric analysis	1	Scientific Literature				Intermediate	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			48688	CHEMBL1155182	19699639	Bioorg. Med. Chem. Lett.	2009	19	19	5684			
CHEMBL1096985	627089	CHEMBL1096985	627089		7	616.71	2.36	172.72	2	ONC(=O)CCCCC[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC1=O	3291075	Inhibition	=	30	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	629199	CHEMBL1121313	B	Inhibition of full length HDAC2 expressed in HEK293 cells at 50 uM after 15 mins by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51141	CHEMBL1158553	20381359	Bioorg. Med. Chem.	2010	18	9	3252	722	CHEMBL3307715	HEK293
CHEMBL481719	474788	CHEMBL481719	474788		12b	392.41	1.26	114.53	0	ONC(=O)c1ccc(CN2[C@H](Cc3c[nH]c4ccccc34)C(=O)NCC2=O)cc1	2489485	IC50	=	1810	nM	5.74			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	515266	CHEMBL991290	B	Inhibition of human recombinant histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45582	CHEMBL1143301	19111466	Bioorg. Med. Chem. Lett.	2009	19	3	688			
CHEMBL552750	557698	CHEMBL552750	557698		10c	290.32	3.18	73.12	0	ONC(=O)\C=C\C=C\c1ccc(cc1)c2ccc(cc2)C#N	2657778	IC50	=	1200	nM	5.92			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL1094108	626207	CHEMBL1094108	626207		13	302.37	3.87	55.12	0	Cc1cccc(c1)c2ccc(N)c(NC(=O)c3ccccc3)c2	3286436	Ratio IC50	=	2					0	BAO_0000179			630933	CHEMBL1116532	B	Selectivity ratio of IC50 for human recombinant HDAC2 preincubated for 1 hr with substrate to IC50 for human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1094108	626207	CHEMBL1094108	626207		13	302.37	3.87	55.12	0	Cc1cccc(c1)c2ccc(N)c(NC(=O)c3ccccc3)c2	3286381	IC50	=	3100	nM	5.51			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1094108	626207	CHEMBL1094108	626207		13	302.37	3.87	55.12	0	Cc1cccc(c1)c2ccc(N)c(NC(=O)c3ccccc3)c2	3286401	IC50	=	7200	nM	5.14			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1767045	1142084	CHEMBL1767045	1142084		40	540.65	4.43	129.55	1	CNC(=O)\C(=N/O)\CCCCC[C@H](N(Cc1ccc(OC)cc1)C(=O)OC(C)(C)C)C(=O)Nc2ccccc2	6174081	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL1958431	1283972	CHEMBL1958431	1283972		10	417.48	2.04	107.56	0	COc1ccc(cc1)N2CCN(CC2)S(=O)(=O)c3cccc(\C=C\C(=O)NO)c3	8054598	ED50	=	36	nM			Non standard unit for type	0	BAO_0003036	UO_0000065	http://www.openphacts.org/units/Nanomolar	808465	CHEMBL1961041	B	Inhibition of human recombinant HDAC2 expressed using baculovirus expression system using Flour- De-Lys as substrate after 3 hrs by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			61278	CHEMBL1955831	22326398	Bioorg. Med. Chem. Lett.	2012	22	5	1886			
CHEMBL2425962	1581081	CHEMBL2425962	1581081		3j	377.44	3.55	82	0	CCC1=Nc2cc(\C=C\C(=O)NO)ccc2C(=O)N1CCCc3ccccc3	13451919	IC50	>	12000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL2407742	1572148	CHEMBL2407742	1572148		8d	426.47	2.78	115.05	0	COc1ccc(NC(=O)c2ccc(CNc3nccc(n3)c4cccnc4)cc2)c(N)c1	13395024	IC50	=	248	nM	6.61			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL556332	563010	CHEMBL556332	563010		1b	255.27	2.59	69.56	0	ONC(=O)\C=C\c1ccc(cc1)c2ccc(O)cc2	14570730	IC50	=	590	nM	6.23			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1335247	CHEMBL3238600	B	Inhibition of HDAC2 in human HeLa cells using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82343	CHEMBL3232764	24742384	Eur. J. Med. Chem.	2014	79		251			
CHEMBL3417211	1840419	CHEMBL3417211	1840419		6c	595.64	3.75	138.21	1	COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(=O)c4cccc(c4)C(=O)Nc5ccccc5N	15218915	IC50	=	4910	nM	5.31			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1471124	CHEMBL3421014	B	Inhibition of recombinant human HDAC2 expressed in baculovirus infected insect High5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91571	CHEMBL3414494	25805446	Eur. J. Med. Chem.	2015	95		127			
CHEMBL3335288	1791421	CHEMBL3335288	1791421		10	259.3	2.48	67.15	0	ONC(=O)CCCCc1ccn(n1)c2ccccc2	15086176	IC50	=	2747	nM	5.56			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1433878	CHEMBL3388839	B	Inhibition of human recombinant HDAC2 after 60 mins by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89339	CHEMBL3352093	25218912	Eur. J. Med. Chem.	2014	86		639			
CHEMBL3317812	1782451	CHEMBL3317812	1782451		5	534.67	.99	230.76	1	C[C@@]12CSC(=N1)c3csc(CNC(=O)C[C@H](OC(=O)[C@H](Cc4c[nH]cn4)NC2=O)\C=C\CCS)n3	15060217	IC50	=	1.4	nM	8.85			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1452234	CHEMBL3366146	B	Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90621	CHEMBL3352389	25070421	Bioorg. Med. Chem. Lett.	2014	24	16	3728			
CHEMBL3355256	1819382	CHEMBL3355256	1819382		35	254.24	2.65	66.76	0	Oc1cccc(\C=C\2/Oc3ccccc3C2=O)c1O	14973541	IC50	=	16400	nM	4.79			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1434457	CHEMBL3388274	B	Inhibition of HDAC2 (unknown origin) after 15 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89860	CHEMBL3352210	25455492	Bioorg. Med. Chem. Lett.	2014	24	23	5497			
CHEMBL3427766	1845162	CHEMBL3427766	1845162		3v	294.35	3.08	76.69	0	Cn1cc(c2n[nH]c3C(CCCc23)C(=O)N)c4ccccc14	15255993	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL1076939	614584	CHEMBL1076939	614584		4h	455.48	3.9	118.37	0	COc1cc(ccc1F)n2cc(nn2)c3cccc(NC(=O)CCCCCCC(=O)NO)c3	3201422	IC50					Not Determined		0	BAO_0000190			616013	CHEMBL1101057	B	Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			50398	CHEMBL1154884	20055418	J. Med. Chem.	2010	53	3	1347			
CHEMBL3317816	1782455	CHEMBL3317816	1782455		9	597.77	1.89	240.41	1	CC(C)(C)OC(=O)NCC[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c3csc(CNC(=O)C[C@H](OC1=O)\C=C\CCS)n3	15060232	IC50	=	3.1	nM	8.51			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1452234	CHEMBL3366146	B	Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90621	CHEMBL3352389	25070421	Bioorg. Med. Chem. Lett.	2014	24	16	3728			
CHEMBL3427761	1845157	CHEMBL3427761	1845157		3q	298.36	3.07	112.9	0	NC(=O)C1CCCc2c1[nH]nc2c3nc4ccccc4s3	15255971	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL486686	499247	CHEMBL486686	499247		3	557.64	.79	171.8	1	CC(C)C[C@H](NC(=O)C)C(=O)NCC(=O)N[C@@H](CCCCNC(=O)C)C(=O)Nc1ccc2C(=CC(=O)Oc2c1)C	3389888	Km	=	3000	nM				0	BAO_0000477	UO_0000065	http://www.openphacts.org/units/Nanomolar	646833	CHEMBL1216974	B	Activity of HDAC2 at 10 uM	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL486686	499247	CHEMBL486686	499247		3	557.64	.79	171.8	1	CC(C)C[C@H](NC(=O)C)C(=O)NCC(=O)N[C@@H](CCCCNC(=O)C)C(=O)Nc1ccc2C(=CC(=O)Oc2c1)C	3389893	Activity					Active		0	BAO_0000375			646833	CHEMBL1216974	B	Activity of HDAC2 at 10 uM	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL1800242	1161305	CHEMBL1800242	1161305		8	301.36	1.77	97.25	0	CC(=O)Nc1ccc(cc1)C(=O)CSc2nccc(C)n2	6283031	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL2057829	1353584	CHEMBL2057829	1353584		1g	365.35	2.56	183.71	0	Nc1ccc(cc1NC(=O)c2ccc(NC(=O)CCN=[N+]=[N-])cc2)N=[N+]=[N-]	10955025	Activity					Active		0	BAO_0000375			829164	CHEMBL2059986	B	Binding affinity to His-tagged human HDAC2 assessed as decrease in biotinylation of HDAC2 at 25 uM preincubated for 24 hrs measured after 1 hr by Western blot analysis in presence of five-fold molar excess of Trichostatin A	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057829	1353584	CHEMBL2057829	1353584		1g	365.35	2.56	183.71	0	Nc1ccc(cc1NC(=O)c2ccc(NC(=O)CCN=[N+]=[N-])cc2)N=[N+]=[N-]	10954405	Ratio IC50	=	1.3					0	BAO_0000179			829156	CHEMBL2059978	B	Ratio of IC50 for human HDAC2 preincubated for 3 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057829	1353584	CHEMBL2057829	1353584		1g	365.35	2.56	183.71	0	Nc1ccc(cc1NC(=O)c2ccc(NC(=O)CCN=[N+]=[N-])cc2)N=[N+]=[N-]	10954418	Ratio IC50	=	1.6					0	BAO_0000179			829157	CHEMBL2059979	B	Ratio of IC50 for human HDAC2 preincubated for 24 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057829	1353584	CHEMBL2057829	1353584		1g	365.35	2.56	183.71	0	Nc1ccc(cc1NC(=O)c2ccc(NC(=O)CCN=[N+]=[N-])cc2)N=[N+]=[N-]	10954455	Inhibition					tde		0	BAO_0000376			829163	CHEMBL2059985	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057829	1353584	CHEMBL2057829	1353584		1g	365.35	2.56	183.71	0	Nc1ccc(cc1NC(=O)c2ccc(NC(=O)CCN=[N+]=[N-])cc2)N=[N+]=[N-]	10954275	IC50	=	120000	nM			Outside typical range	0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829146	CHEMBL2059968	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 5 mins measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057829	1353584	CHEMBL2057829	1353584		1g	365.35	2.56	183.71	0	Nc1ccc(cc1NC(=O)c2ccc(NC(=O)CCN=[N+]=[N-])cc2)N=[N+]=[N-]	10954288	IC50	=	94000	nM	4.03			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829147	CHEMBL2059969	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 3 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057829	1353584	CHEMBL2057829	1353584		1g	365.35	2.56	183.71	0	Nc1ccc(cc1NC(=O)c2ccc(NC(=O)CCN=[N+]=[N-])cc2)N=[N+]=[N-]	10954301	IC50	=	77000	nM	4.11			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829148	CHEMBL2059970	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 24 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL1307946	731830	CHEMBL1307946	731830		19	290.34	2.93	97.61	0	COc1ccc(cc1)C(=O)CSc2nc(C)cc(O)n2	6283042	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL27759	36237	CHEMBL27759	36237	ENTINOSTAT	MS-275	376.41	2.07	106.33	0	Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2	2073910	IC50	=	340	nM	6.47			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	461756	CHEMBL927762	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38240	CHEMBL1140803	18060775	Bioorg. Med. Chem. Lett.	2008	18	2	726			
CHEMBL256440	436057	CHEMBL256440	436057		9	295.36	2.19	96.24	0	Nc1ccc(cc1NC(=O)c2cccnc2)c3cccs3	2401160	IC50	=	390	nM	6.41			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	493107	CHEMBL940370	B	Inhibition of human HDAC2 expressed in mammalian cells	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45872	CHEMBL1152282	18951790	Bioorg. Med. Chem. Lett.	2008	18	23	6104			
CHEMBL561604	559202	CHEMBL561604	559202		4n, ST5732	465.46	4.82	172.55	0	ONC(=O)CCCCCC(c1c[nH]c2ccc(cc12)[N+](=O)[O-])c3c[nH]c4ccc(cc34)[N+](=O)[O-]	2720674	IC50	=	590	nM	6.23			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	585885	CHEMBL1053556	B	Inhibition of human HDAC2 by fluorimetry	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	48183	CHEMBL1153591	19359173	Bioorg. Med. Chem. Lett.	2009	19	10	2840			
CHEMBL564916	562790	CHEMBL564916	562790		4q, ST3071	450.57	6.05	86.7	1	Nc1ccccc1NC(=O)CCCCCC(c2c[nH]c3ccccc23)c4c[nH]c5ccccc45	2720676	IC50	=	1100	nM	5.96			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	585885	CHEMBL1053556	B	Inhibition of human HDAC2 by fluorimetry	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	48183	CHEMBL1153591	19359173	Bioorg. Med. Chem. Lett.	2009	19	10	2840			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	1, TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	3328498	Ki	=	.76	nM	9.12			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	638008	CHEMBL1166729	B	Inhibition of recombinant HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51491	CHEMBL1165890	20223566	Eur. J. Med. Chem.	2010	45	6	2095			
CHEMBL1164671	646633	CHEMBL1164671	646633		50c	348.42	3.02	119.57	0	Nc1ccc(cc1NC(=O)c2ccc(cc2)\N=C\C=N)c3cccs3	3328508	IC50	=	20	nM	7.7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	638008	CHEMBL1166729	B	Inhibition of recombinant HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51491	CHEMBL1165890	20223566	Eur. J. Med. Chem.	2010	45	6	2095			
CHEMBL27759	36237	CHEMBL27759	36237	ENTINOSTAT	MS275	376.41	2.07	106.33	0	Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2	3329000	IC50	=	15	nM	7.82			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	639057	CHEMBL1166310	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51553	CHEMBL1165952	20472442	Bioorg. Med. Chem.	2010	18	11	4103			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	12659624	IC50	=	537	nM	6.27			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	938235	CHEMBL2328538	B	Inhibition of C-terminal His-tagged full length human recombinant HDAC2 expressed in baculovirus expression system using fluorogenic acetylated peptide as substrate preincubated with enzyme for 10 mins prior to substrate addition measured after 60 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72033	CHEMBL2321647		ACS Med. Chem. Lett.	2013	4	1	132			
CHEMBL2323287	1517444	CHEMBL2323287	1517444		8	605.77	3.46	211.59	1	CCCCCCCC(=O)SCC\C=C\[C@@H]1CC(=O)NCc2nc(cs2)c3nnnn3CC(=O)N[C@@H](C(C)C)C(=O)O1	12659626	IC50	=	25100	nM	4.6			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	938235	CHEMBL2328538	B	Inhibition of C-terminal His-tagged full length human recombinant HDAC2 expressed in baculovirus expression system using fluorogenic acetylated peptide as substrate preincubated with enzyme for 10 mins prior to substrate addition measured after 60 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72033	CHEMBL2321647		ACS Med. Chem. Lett.	2013	4	1	132			
CHEMBL2323289	1517446	CHEMBL2323289	1517446		4	604.78	4.36	198.7	1	CCCCCCCC(=O)SCC\C=C\[C@@H]1CC(=O)NCc2nc(cs2)c3cn(CC(=O)N[C@@H](C(C)C)C(=O)O1)nn3	12659630	IC50	=	32100	nM	4.49			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	938235	CHEMBL2328538	B	Inhibition of C-terminal His-tagged full length human recombinant HDAC2 expressed in baculovirus expression system using fluorogenic acetylated peptide as substrate preincubated with enzyme for 10 mins prior to substrate addition measured after 60 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72033	CHEMBL2321647		ACS Med. Chem. Lett.	2013	4	1	132			
CHEMBL1173445	651590	CHEMBL1173445	651590	LARGAZOLE	3	622.86	5.17	205.66	2	CCCCCCCC(=O)SCC\C=C\[C@@H]1CC(=O)NCc2nc(cs2)C3=N[C@@](C)(CS3)C(=O)N[C@@H](C(C)C)C(=O)O1	12659631	IC50	=	1720	nM	5.76			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	938235	CHEMBL2328538	B	Inhibition of C-terminal His-tagged full length human recombinant HDAC2 expressed in baculovirus expression system using fluorogenic acetylated peptide as substrate preincubated with enzyme for 10 mins prior to substrate addition measured after 60 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72033	CHEMBL2321647		ACS Med. Chem. Lett.	2013	4	1	132			
CHEMBL2018302	1336035	CHEMBL2018302	1336035	TUBASTATIN A	Tubastatin A	335.4	3.08	57.5	0	CN1CCc2c(C1)c3ccccc3n2Cc4ccc(cc4)C(=O)NO	12680986	IC50	=	360	nM	6.44			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	944722	CHEMBL2340968	B	Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	12680987	IC50	=	11	nM	7.96			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	944722	CHEMBL2340968	B	Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772			
CHEMBL2333344	1522982	CHEMBL2333344	1522982		12	141.17	1.27	49.33	0	ONC(=O)C1=CCCCC1	12680990	IC50	=	1050	nM	5.98			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	944722	CHEMBL2340968	B	Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772			
CHEMBL152162	256900	CHEMBL152162	256900		10	165.19	1.34	49.33	0	ONC(=O)CCc1ccccc1	12680992	IC50	=	2720	nM	5.57			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	944722	CHEMBL2340968	B	Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772			
CHEMBL2333343	1522981	CHEMBL2333343	1522981		7	194.19	.05	78.43	0	CNC(=O)c1ccc(cc1)C(=O)NO	12680995	IC50	=	1610	nM	5.79			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	944722	CHEMBL2340968	B	Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772			
CHEMBL2333341	1522979	CHEMBL2333341	1522979		5	270.28	1.64	78.43	0	ONC(=O)c1ccc(cc1)C(=O)NCc2ccccc2	12680997	IC50	=	381	nM	6.42			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	944722	CHEMBL2340968	B	Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	1, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	12685371	Inhibition					tde		0	BAO_0000376			945439	CHEMBL2342550	B	Inhibition of HDAC2 in human MDA-MB-231 cells assessed as decrease in acetylation levels of histone H4 at 1 uM by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			72255	CHEMBL2331319		ACS Med. Chem. Lett.	2013	4	2	235			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	1, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	12685380	IC50	=	256	nM	6.59			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	945444	CHEMBL2342555	B	Inhibition of HDAC2 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate preincubated with enzyme for 5 mins prior to substrate addition measured after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72255	CHEMBL2331319		ACS Med. Chem. Lett.	2013	4	2	235			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA, vorinostat	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	12622654	IC50	=	920	nM	6.04			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	936031	CHEMBL2318997	B	Inhibition of human HDAC2 by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	71849	CHEMBL2311425	23252603	J. Med. Chem.	2013	56	2	427			
CHEMBL2312167	1511211	CHEMBL2312167	1511211		19h	294.35	2.2	87.66	0	Cc1ccc(cc1C)C(=O)NOCCCCCC(=O)NO	12622656	IC50	=	944	nM	6.03			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	936031	CHEMBL2318997	B	Inhibition of human HDAC2 by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	71849	CHEMBL2311425	23252603	J. Med. Chem.	2013	56	2	427			
CHEMBL2312164	1511208	CHEMBL2312164	1511208		19e	280.32	1.72	87.66	0	Cc1cccc(c1)C(=O)NOCCCCCC(=O)NO	12622657	IC50	=	1392	nM	5.86			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	936031	CHEMBL2318997	B	Inhibition of human HDAC2 by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	71849	CHEMBL2311425	23252603	J. Med. Chem.	2013	56	2	427			
CHEMBL2333344	1522982	CHEMBL2333344	1522982		12	141.17	1.27	49.33	0	ONC(=O)C1=CCCCC1	12678227	Inhibition					Not Active		0	BAO_0000376			944716	CHEMBL2340962	B	Inhibition of HDAC2 in human HeLa cells assessed as increase in acetylated H3 at 30 uM measured after 24 hrs by Western blotting analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772	308	CHEMBL3308376	HeLa
CHEMBL2333343	1522981	CHEMBL2333343	1522981		7	194.19	.05	78.43	0	CNC(=O)c1ccc(cc1)C(=O)NO	12678233	Inhibition					Not Active		0	BAO_0000376			944716	CHEMBL2340962	B	Inhibition of HDAC2 in human HeLa cells assessed as increase in acetylated H3 at 30 uM measured after 24 hrs by Western blotting analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772	308	CHEMBL3308376	HeLa
CHEMBL2347011	1528835	CHEMBL2347011	1528835		6b					C[C@@H]1C[C@H](OC(=O)NCc2ccc(cc2)c3cn(CCCCCCC(=O)NO)nn3)[C@@H]4[C@@H](CC[C@@H]5C[C@H](CC(=O)O5)O[Si](C)(C)C(C)(C)C)[C@@H](C)C=CC4=C1	12718186	IC50	=	881.8	nM	6.05			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	950484	CHEMBL2351477	B	Inhibition of recombinant HDAC2 (unknown origin) after 10 mins by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72873	CHEMBL2346500	23570542	J. Med. Chem.	2013	56	9	3645			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	12718188	IC50	=	100.9	nM	7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	950484	CHEMBL2351477	B	Inhibition of recombinant HDAC2 (unknown origin) after 10 mins by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72873	CHEMBL2346500	23570542	J. Med. Chem.	2013	56	9	3645			
CHEMBL272980	434834	CHEMBL272980	434834	MOCETINOSTAT	Mocetinostat	396.44	2.8	105.82	0	Nc1ccccc1NC(=O)c2ccc(CNc3nccc(n3)c4cccnc4)cc2	15218951	IC50	=	170	nM	6.77			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1471124	CHEMBL3421014	B	Inhibition of recombinant human HDAC2 expressed in baculovirus infected insect High5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91571	CHEMBL3414494	25805446	Eur. J. Med. Chem.	2015	95		127			
CHEMBL3311472	1780582	CHEMBL3311472	1780582		20	333.38	1.29	107.53	0	ONC(=O)CCCCCCNC(=O)c1ccc2NC(=O)CCc2c1	15053556	IC50	=	20	nM	7.7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1450057	CHEMBL3373319	B	Inhibition of human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90190	CHEMBL3351757	24864038	Bioorg. Med. Chem.	2014	22	14	3720			
CHEMBL3426906	1844293	CHEMBL3426906	1844293		5c	371.37	-.54	152.57	0	ONC(=O)CCCCCOc1no[n+]([O-])c1S(=O)(=O)c2ccccc2	15249663	IC50	=	380.5	nM	6.42			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1476047	CHEMBL3428543	B	Inhibition of full length human recombinant HDAC2 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Ac)-AMC as substrate after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91812	CHEMBL3425494	25906087	J. Med. Chem.	2015	58	10	4325			
CHEMBL3426906	1844293	CHEMBL3426906	1844293		5c	371.37	-.54	152.57	0	ONC(=O)CCCCCOc1no[n+]([O-])c1S(=O)(=O)c2ccccc2	15249677	Inhibition					Active		0	BAO_0000376			1476055	CHEMBL3428551	B	Inhibition of HDAC2 in human MV4-11 cells assessed as increase in level of acetylated histone H3 and histone H4 at 12.5 to 200 nM after 3 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91812	CHEMBL3425494	25906087	J. Med. Chem.	2015	58	10	4325			
CHEMBL3426906	1844293	CHEMBL3426906	1844293		5c	371.37	-.54	152.57	0	ONC(=O)CCCCCOc1no[n+]([O-])c1S(=O)(=O)c2ccccc2	15249678	Inhibition					Active		0	BAO_0000376			1476056	CHEMBL3428552	B	Inhibition of HDAC2 in human HEL cells at 1 to 10 uM after 3 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91812	CHEMBL3425494	25906087	J. Med. Chem.	2015	58	10	4325			
CHEMBL3426906	1844293	CHEMBL3426906	1844293		5c	371.37	-.54	152.57	0	ONC(=O)CCCCCOc1no[n+]([O-])c1S(=O)(=O)c2ccccc2	15249679	Inhibition					Not Active		0	BAO_0000376			1476057	CHEMBL3428553	B	Inhibition of HDAC2 in human HEL cells at 10 uM after 5 hrs by Western blot analysis in presence of nitric oxide scavenger PTIO	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91812	CHEMBL3425494	25906087	J. Med. Chem.	2015	58	10	4325			
CHEMBL211625	354143	CHEMBL211625	354143		9	377.44	3.23	85.61	0	COc1ccc(NCc2ccc(cc2)C(=O)Nc3ccccc3N)cc1OC	1998272	IC50	=	500	nM	6.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL211625	354143	CHEMBL211625	354143		9	377.44	3.23	85.61	0	COc1ccc(NCc2ccc(cc2)C(=O)Nc3ccccc3N)cc1OC	1998355	Inhibition	<	50	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	451049	CHEMBL900130	B	Inhibition of human recombinant HDAC2 at 20 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL487533	508152	CHEMBL487533	508152		6a	421.49	3.72	109.14	0	ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)c2cn(Cc3ccccc3)nn2	2351869	IC50	=	679	nM	6.17			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL466459	479515	CHEMBL466459	479515		15	562.53	2.77	197.91	1	CC(C)(C)OC(=O)Nc1ccc(cc1)c2onc(c2)C(=O)NCC(=O)Nc3ccc(cc3)c4onc(c4)C(=O)NO	2641988	IC50	>	30000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	500548	CHEMBL971413	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			46730	CHEMBL1136917	19419863	Bioorg. Med. Chem. Lett.	2009	19	11	3023			
CHEMBL3427744	1845140	CHEMBL3427744	1845140		3b	275.73	3.25	71.77	0	NC(=O)C1CCCc2c1[nH]nc2c3ccc(Cl)cc3	15255895	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL1095096	626203	CHEMBL1095096	626203		9	289.33	2.24	68.01	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccncc3	3286432	Ratio IC50	=	14					0	BAO_0000179			630933	CHEMBL1116532	B	Selectivity ratio of IC50 for human recombinant HDAC2 preincubated for 1 hr with substrate to IC50 for human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1083439	632307	CHEMBL1083439	632307		5b	293.32	1.17	107.53	0	ONC(=O)CCCCCNC(=O)NC(=O)c1ccccc1	3311478	Ki	=	44	nM	7.36			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	633817	CHEMBL1119895	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51319	CHEMBL1155491	20451378	Bioorg. Med. Chem. Lett.	2010	20	11	3314			
CHEMBL1095096	626203	CHEMBL1095096	626203		9	289.33	2.24	68.01	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccncc3	3286385	IC50	=	270	nM	6.57			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1095096	626203	CHEMBL1095096	626203		9	289.33	2.24	68.01	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccncc3	3286405	IC50	=	3900	nM	5.41			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL503	9495	CHEMBL503	9495	LOVASTATIN	1	404.54	4.22	72.83	0	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12	12718190	IC50	=	25933	nM	4.59			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	950484	CHEMBL2351477	B	Inhibition of recombinant HDAC2 (unknown origin) after 10 mins by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72873	CHEMBL2346500	23570542	J. Med. Chem.	2013	56	9	3645			
CHEMBL251010	416382	CHEMBL251010	416382		7b	294.35	1.63	87.66	0	COC(CCCCCC(=O)NO)C(=O)Nc1ccccc1	2049603	Activity					Not Active		0	BAO_0000375			458150	CHEMBL925483	B	Inhibition of HDAC2 in HeLa cell lysates at 0.1 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL392747	399319	CHEMBL392747	399319		11	453.53	4.75	85.61	0	COc1ccc(NCc2ccc(cc2)C(=O)Nc3cc(ccc3N)c4ccccc4)cc1OC	1998270	IC50	=	100	nM	7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL227118	382030	CHEMBL227118	382030		3	323.43	1.86	90.46	0	ONC(=O)CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2	1902515	IC50	=	1050	nM	5.98			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	439074	CHEMBL889422	B	Inhibition of His-tagged HDAC2 expressed in Sf9 cells by fluorescence-based assay	1	Scientific Literature				Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			36060	CHEMBL1145385	17539623	J. Med. Chem.	2007	50	13	3054	1759	CHEMBL3308860	Sf9
CHEMBL392747	399319	CHEMBL392747	399319		11	453.53	4.75	85.61	0	COc1ccc(NCc2ccc(cc2)C(=O)Nc3cc(ccc3N)c4ccccc4)cc1OC	1998353	Inhibition	<	50	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	451049	CHEMBL900130	B	Inhibition of human recombinant HDAC2 at 20 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL251010	416382	CHEMBL251010	416382		7b	294.35	1.63	87.66	0	COC(CCCCCC(=O)NO)C(=O)Nc1ccccc1	2049521	IC50	=	500	nM	6.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL251144	414378	CHEMBL251144	414378		5a	464.52	3.45	113.32	0	Nc1ccccc1NC(=O)c2ccc(cc2)C(C(=O)Nc3ccccc3)C(=O)Nc4ccccc4	2035362	IC50	=	313	nM	6.5			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	456403	CHEMBL907492	B	Inhibition of human HDAC2 expressed in domain of SMRT	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37650	CHEMBL1140029	17555962	Bioorg. Med. Chem. Lett.	2007	17	16	4619			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	14, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	1861906	Activity					Active		0	BAO_0000375			434815	CHEMBL917043	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			35656	CHEMBL1139873	17447750	J. Med. Chem.	2007	50	10	2497			
CHEMBL251206	416378	CHEMBL251206	416378		4b	280.32	1.17	87.66	0	COC(CCCCC(=O)NO)C(=O)Nc1ccccc1	2049525	IC50	=	500	nM	6.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL427135	301117	CHEMBL427135	301117		6	309.43	1.99	109.03	0	SCC(=O)NCCCCCCNC(=O)Nc1ccccc1	1902512	IC50	>	30000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	439074	CHEMBL889422	B	Inhibition of His-tagged HDAC2 expressed in Sf9 cells by fluorescence-based assay	1	Scientific Literature				Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			36060	CHEMBL1145385	17539623	J. Med. Chem.	2007	50	13	3054	1759	CHEMBL3308860	Sf9
CHEMBL237584	399317	CHEMBL237584	399317		10	459.56	4.7	113.85	0	COc1ccc(NCc2ccc(cc2)C(=O)Nc3cc(ccc3N)c4cccs4)cc1OC	1998271	IC50	=	80	nM	7.1			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL237584	399317	CHEMBL237584	399317		10	459.56	4.7	113.85	0	COc1ccc(NCc2ccc(cc2)C(=O)Nc3cc(ccc3N)c4cccs4)cc1OC	1998354	Inhibition	<	50	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	451049	CHEMBL900130	B	Inhibition of human recombinant HDAC2 at 20 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL250826	416521	CHEMBL250826	416521		10b	308.37	2.08	87.66	0	COC(CCCCCCC(=O)NO)C(=O)Nc1ccccc1	2049593	Activity					Not Active		0	BAO_0000375			458150	CHEMBL925483	B	Inhibition of HDAC2 in HeLa cell lysates at 0.1 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL27759	36237	CHEMBL27759	36237	ENTINOSTAT	1g, MS-275	376.41	2.07	106.33	0	Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2	2106274	IC50					Not Determined		0	BAO_0000190			464924	CHEMBL946981	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38494	CHEMBL1142268	18247554	J. Med. Chem.	2008	51	6	1505			
CHEMBL488747	508478	CHEMBL488747	508478		14a	421.49	3.58	109.14	0	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)c2cnnn2Cc3ccccc3	2351857	IC50	=	112	nM	6.95			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL511797	517011	CHEMBL511797	517011		13	433.57	2.61	111.52	0	Nc1ccc(cc1NC(=O)c2ccc(nc2)N3CCC4(CCNC4)CC3)c5ccsc5	2380643	IC50	=	71	nM	7.15			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	493107	CHEMBL940370	B	Inhibition of human HDAC2 expressed in mammalian cells	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45872	CHEMBL1152282	18951790	Bioorg. Med. Chem. Lett.	2008	18	23	6104			
CHEMBL1095412	626204	CHEMBL1095412	626204		10	318.37	3.37	64.35	0	COc1ccc(cc1)c2ccc(N)c(NC(=O)c3ccccc3)c2	3286433	Ratio IC50	=	6					0	BAO_0000179			630933	CHEMBL1116532	B	Selectivity ratio of IC50 for human recombinant HDAC2 preincubated for 1 hr with substrate to IC50 for human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1093335	620618	CHEMBL1093335	620618		33	449.56	5.85	68.36	1	CC(C)(C)c1[nH]c2ccccc2c1[C@@H]3CCCN(Cc4ccc(\C=C\C(=O)NO)cc4F)C3	3259662	IC50	=	48	nM	7.32			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	625339	CHEMBL1111713	B	Inhibition of HDAC2 expressed in baculovirus system by fluorescent assay	1	Scientific Literature				Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			50650	CHEMBL1156307	20205394	J. Med. Chem.	2010	53	7	2952			
CHEMBL430060	275631	CHEMBL430060	275631	APICIDIN	7	623.78	1.58	138.84	1	CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cn(OC)c3ccccc23)NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]4CCCCN4C1=O	3389924	Ki	=	.12	nM	9.92			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL1095412	626204	CHEMBL1095412	626204		10	318.37	3.37	64.35	0	COc1ccc(cc1)c2ccc(N)c(NC(=O)c3ccccc3)c2	3286384	IC50	=	140	nM	6.85			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1095412	626204	CHEMBL1095412	626204		10	318.37	3.37	64.35	0	COc1ccc(cc1)c2ccc(N)c(NC(=O)c3ccccc3)c2	3286404	IC50	=	860	nM	6.07			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL235210	399345	CHEMBL235210	399345		23	324.4	3.32	92.59	0	COc1ccc(cc1)C(=O)Nc2cc(ccc2N)c3cccs3	1998325	Inhibition	<	50	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	451049	CHEMBL900130	B	Inhibition of human recombinant HDAC2 at 20 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL251212	416518	CHEMBL251212	416518		10a	294.35	1.67	98.66	0	ONC(=O)CCCCCCC(O)C(=O)Nc1ccccc1	2049594	Activity					Not Active		0	BAO_0000375			458150	CHEMBL925483	B	Inhibition of HDAC2 in HeLa cell lysates at 0.1 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL152133	256339	CHEMBL152133	256339		19a, SK-7041	339.39	2.27	81.67	0	CN(C)c1ccc(cc1)C(=O)NCc2ccc(\C=C\C(=O)NO)cc2	2106246	Inhibition	>	90	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	464972	CHEMBL947144	B	Inhibition of HDAC2 at 1 uM	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38494	CHEMBL1142268	18247554	J. Med. Chem.	2008	51	6	1505			
CHEMBL485514	500028	CHEMBL485514	500028		32	350.41	3.02	78.43	0	ONC(=O)CCCCCNC(=O)C=C1c2ccccc2c3ccccc13	2306400	IC50	=	.8	nM	9.1			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	521104	CHEMBL960365	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46897	CHEMBL1137690	18672316	Eur. J. Med. Chem.	2009	44	3	1067			
CHEMBL255805	436056	CHEMBL255805	436056		8	289.33	2.24	68	0	Nc1ccc(cc1NC(=O)c2cccnc2)c3ccccc3	2401161	IC50	=	900	nM	6.05			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	493107	CHEMBL940370	B	Inhibition of human HDAC2 expressed in mammalian cells	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45872	CHEMBL1152282	18951790	Bioorg. Med. Chem. Lett.	2008	18	23	6104			
CHEMBL475714	519580	CHEMBL475714	519580		13d	336.41	.65	122.55	0	NS(=O)(=O)NCCCCCC(=O)Nc1cnc2ccccc2c1	2600492	Activity					Not Active		0	BAO_0000375			540708	CHEMBL1027321	B	Inhibition of human recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus by fluorimetry	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			46637	CHEMBL1149076	19084395	Bioorg. Med. Chem. Lett.	2009	19	2	336			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	2351870	IC50	=	14	nM	7.85			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL1097744	626282	CHEMBL1097744	626282		14	333.34	3.28	100.94	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3cccc(c3)[N+](=O)[O-]	3286437	Ratio IC50	=	10					0	BAO_0000179			630933	CHEMBL1116532	B	Selectivity ratio of IC50 for human recombinant HDAC2 preincubated for 1 hr with substrate to IC50 for human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1094707	614706	CHEMBL1094707	614706		4j	413.51	3.99	109.14	0	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)c2cn(nn2)C3CCCCC3	3201396	IC50	=	27.5	nM	7.56			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	616013	CHEMBL1101057	B	Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			50398	CHEMBL1154884	20055418	J. Med. Chem.	2010	53	3	1347			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	1b, TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	3201445	IC50	=	14	nM	7.85			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	616013	CHEMBL1101057	B	Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			50398	CHEMBL1154884	20055418	J. Med. Chem.	2010	53	3	1347			
CHEMBL1097744	626282	CHEMBL1097744	626282		14	333.34	3.28	100.94	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3cccc(c3)[N+](=O)[O-]	3286380	IC50	=	21000	nM	4.68			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1097744	626282	CHEMBL1097744	626282		14	333.34	3.28	100.94	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3cccc(c3)[N+](=O)[O-]	3286400	IC50	=	200000	nM			Outside typical range	0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL235210	399345	CHEMBL235210	399345		50b	324.4	3.32	92.59	0	COc1ccc(cc1)C(=O)Nc2cc(ccc2N)c3cccs3	3328509	IC50	=	200	nM	6.7			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	638008	CHEMBL1166729	B	Inhibition of recombinant HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51491	CHEMBL1165890	20223566	Eur. J. Med. Chem.	2010	45	6	2095			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	3328990	IC50	=	1	nM	9			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	639057	CHEMBL1166310	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51553	CHEMBL1165952	20472442	Bioorg. Med. Chem.	2010	18	11	4103			
CHEMBL55895	81957	CHEMBL55895	81957	PHENYLBUTYRYLHYDROXAMIC ACID	4	179.22	1.79	49.33	0	ONC(=O)CCCc1ccccc1	5207878	IC50	=	600	nM	6.22			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	718469	CHEMBL1680133	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	55650	CHEMBL1671826	21874153	ACS Med. Chem. Lett.	2011	2	1	39			
CHEMBL3262727	1747698	CHEMBL3262727	1747698		12	343.36	2.01	109.66	0	ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)n2ccc3cccnc23	14660291	IC50	=	1160	nM	5.94			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1349595	CHEMBL3265664	B	Inhibition of HDAC2 (unknown origin) using RHKK(Ac) (379 to 382) p53 peptide as substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	83197	CHEMBL3259569	24766560	J. Med. Chem.	2014	57	10	4009			
CHEMBL3421746	1841182	CHEMBL3421746	1841182		10j	433.89	3.24	106.07	0	Nc1ccccc1NC(=O)c2ccc(CNCc3onc(n3)c4ccccc4Cl)cc2	15234975	IC50	=	320	nM	6.49			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL325676	184152	CHEMBL325676	184152		15	237.36	3.19	67.9	0	SCCCCCCC(=O)Nc1ccccc1	15138247	IC50	=	1300	nM	5.89			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3356932	1821075	CHEMBL3356932	1821075		18, ST7881	319.39	4.14	67.9	0	FC(F)(F)c1ccc(CNC(=O)CCCCCCS)cc1	15138287	IC50	=	19400	nM	4.71			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3098691	1609462	CHEMBL3098691	1609462		8	390.43	.4	136.63	0	ONC(=O)CCCCC[C@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)Nc2ccccc2	14976177	IC50	=	89	nM	7.05			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1444620	CHEMBL3376039	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90082	CHEMBL3352629	25563890	Bioorg. Med. Chem. Lett.	2015	25	3	459			
CHEMBL2022825	1338197	CHEMBL2022825	1338197		3	592.8	7.5	172.05	2	O=C(N[C@@H](CCCCCCSSc1ccccn1)C(=O)Nc2nc(cs2)c3ccccc3)OCc4ccccc4	10862524	IC50	=	3.9	nM	8.41			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	816365	CHEMBL2024763	B	Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	61731	CHEMBL2021837	22465091	Eur. J. Med. Chem.	2012	52		111			
CHEMBL575258	570721	CHEMBL575258	570721		8	241.29	2.83	49.33	0	ONC(=O)C(Cc1ccccc1)c2ccccc2	2922896	Inhibition					Not Active		0	BAO_0000376			592005	CHEMBL1050120	B	Inhibition of recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus at 20 uM after 10 mins by fluorimetric analysis	1	Scientific Literature				Intermediate	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			48688	CHEMBL1155182	19699639	Bioorg. Med. Chem. Lett.	2009	19	19	5684			
CHEMBL1097746	626284	CHEMBL1097746	626284		16	330.38	3.13	72.19	0	CC(=O)c1cccc(c1)c2ccc(N)c(NC(=O)c3ccccc3)c2	3286438	Ratio IC50	=	2					0	BAO_0000179			630933	CHEMBL1116532	B	Selectivity ratio of IC50 for human recombinant HDAC2 preincubated for 1 hr with substrate to IC50 for human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1097746	626284	CHEMBL1097746	626284		16	330.38	3.13	72.19	0	CC(=O)c1cccc(c1)c2ccc(N)c(NC(=O)c3ccccc3)c2	3286378	IC50	=	13000	nM	4.89			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1097746	626284	CHEMBL1097746	626284		16	330.38	3.13	72.19	0	CC(=O)c1cccc(c1)c2ccc(N)c(NC(=O)c3ccccc3)c2	3286398	IC50	=	27000	nM	4.57			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL2425968	1581087	CHEMBL2425968	1581087		4b	381.4	3.29	82	0	CCC1=Nc2cc(F)c(\C=C\C(=O)NO)cc2C(=O)N1CCc3ccccc3	13451913	IC50	=	5680	nM	5.25			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL2407716	1572122	CHEMBL2407716	1572122		30c	419.56	5.09	118.08	1	Nc1ccccc1NC(=O)c2ccc(CSC3=N[C@H](CS3)c4ccccc4)cc2	13395009	IC50	=	440	nM	6.36			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL487106	508479	CHEMBL487106	508479		14b	439.48	3.79	109.14	0	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)c2cnnn2Cc3ccc(F)cc3	2351856	IC50	=	124	nM	6.91			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL3086767	1604238	CHEMBL3086767	1604238		1, natural product, SCA, santacruzamate A	278.35	1.9	67.43	0	CCOC(=O)NCCCC(=O)NCCc1ccccc1	13838848	Inhibition					Active		0	BAO_0000376			1276437	CHEMBL3088533	B	Inhibition of human recombinant HDAC2 at 1 uM after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			76042	CHEMBL3085682	24164245	J. Nat. Prod.	2013	76	11	2026			
CHEMBL3086767	1604238	CHEMBL3086767	1604238		1, natural product, SCA, santacruzamate A	278.35	1.9	67.43	0	CCOC(=O)NCCCC(=O)NCCc1ccccc1	13838875	IC50	=	.119	nM	9.92			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1276444	CHEMBL3088540	B	Inhibition of human recombinant HDAC2 after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76042	CHEMBL3085682	24164245	J. Nat. Prod.	2013	76	11	2026			
CHEMBL3427778	1845174	CHEMBL3427778	1845174		17	337.8	4.31	71.77	0	NC(=O)C1Cc2ccccc2Cc3c1[nH]nc3c4ccc(Cl)cc4	15256005	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL399494	423444	CHEMBL399494	423444		15e	395.47	3.46	121.69	0	CCOC(=O)NCc1ccc(cc1)C(=O)Nc2cc(ccc2N)c3cccs3	2073947	IC50	=	71	nM	7.15			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	461756	CHEMBL927762	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38240	CHEMBL1140803	18060775	Bioorg. Med. Chem. Lett.	2008	18	2	726			
CHEMBL406800	439216	CHEMBL406800	439216		79b, SB-379278A	177.23	.48	69.04	0	S=C1NC=C(N1)c2ccncc2	2106210	IC50					Not Determined		0	BAO_0000190			464924	CHEMBL946981	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38494	CHEMBL1142268	18247554	J. Med. Chem.	2008	51	6	1505			
CHEMBL518957	474790	CHEMBL518957	474790		7d	393.46	3.1	109.91	0	ONC(=O)c1ccc(CN2[C@H](Cc3cccs3)C(=O)Nc4ccccc24)cc1	2489477	IC50	=	870	nM	6.06			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	515266	CHEMBL991290	B	Inhibition of human recombinant histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45582	CHEMBL1143301	19111466	Bioorg. Med. Chem. Lett.	2009	19	3	688			
CHEMBL493347	476989	CHEMBL493347	476989		13f	368.47	1.41	150.8	0	NS(=O)(=O)NCCCCCC(=O)Nc1nc(cs1)c2ccccc2	2600490	Activity					Not Active		0	BAO_0000375			540708	CHEMBL1027321	B	Inhibition of human recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus by fluorimetry	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			46637	CHEMBL1149076	19084395	Bioorg. Med. Chem. Lett.	2009	19	2	336			
CHEMBL491316	457921	CHEMBL491316	457921		23	404.5	4.05	70.39	0	ONC(=O)\C=C\c1ccc2c(c1)nc(CCc3ccccc3)n2CCN4CCCC4	2284817	Ki	=	36.2	nM	7.44			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	543447	CHEMBL1015995	B	Inhibition of recombinant HDAC2 by fluorimetric assay	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			46085	CHEMBL1152878	19181524	Bioorg. Med. Chem. Lett.	2009	19	5	1403			
CHEMBL468842	488397	CHEMBL468842	488397		11	388.42	1.66	133.56	0	CC(=O)Nc1ccc(cc1)c2onc(c2)C(=O)NCCCCCCC(=O)NO	2569570	IC50	=	131	nM	6.88			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	514670	CHEMBL976442	B	Inhibition of HDAC2 after 17 hrs	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			44070	CHEMBL1155917	18642892	J. Med. Chem.	2008	51	15	4370			
CHEMBL469274	488315	CHEMBL469274	488315		3	446.5	3.23	142.79	0	CC(C)(C)OC(=O)Nc1cccc(c1)c2onc(c2)C(=O)NCCCCCCC(=O)NO	2569578	IC50	=	238	nM	6.62			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	514670	CHEMBL976442	B	Inhibition of HDAC2 after 17 hrs	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			44070	CHEMBL1155917	18642892	J. Med. Chem.	2008	51	15	4370			
CHEMBL573189	570720	CHEMBL573189	570720		7	165.19	1.34	49.33	0	CC(C(=O)NO)c1ccccc1	2922895	Inhibition					Not Active		0	BAO_0000376			592005	CHEMBL1050120	B	Inhibition of recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus at 20 uM after 10 mins by fluorimetric analysis	1	Scientific Literature				Intermediate	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			48688	CHEMBL1155182	19699639	Bioorg. Med. Chem. Lett.	2009	19	19	5684			
CHEMBL1096986	627090	CHEMBL1096986	627090		8	655.74	2.65	188.51	2	ONC(=O)CCCCC[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]4CCCN4C(=O)[C@H](Cc5c[nH]c6ccccc56)NC1=O	3291084	Inhibition	=	34	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	629200	CHEMBL1121314	B	Inhibition of full length HDAC2 expressed in HEK293 cells at 100 uM after 15 mins by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51141	CHEMBL1158553	20381359	Bioorg. Med. Chem.	2010	18	9	3252	722	CHEMBL3307715	HEK293
CHEMBL1631911	1054903	CHEMBL1631911	1054903		(R/S)-8b	378.46	2.98	96.89	0	ONC(=O)CCCCCC1OCCCCCCOc2ccccc2NC1=O	5090669	IC50	=	1570	nM	5.8			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	690171	CHEMBL1634301	B	Inhibition of human HDAC2 by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	54338	CHEMBL1629537	21073160	J. Med. Chem.	2010	53	23	8387			
CHEMBL2047614	1351038	CHEMBL2047614	1351038		7b	478.77	6.67	46.92	1	Clc1ccc(NC(=O)\C=C/c2cn(nc2c3ccc(Br)cc3)c4ccccc4)cc1	10947981	IC50	=	4990	nM	5.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	827843	CHEMBL2051252	B	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62524	CHEMBL2046430	22705022	Bioorg. Med. Chem.	2012	20	14	4430			
CHEMBL2047616	1351040	CHEMBL2047616	1351040		7d	474.35	5.99	56.15	1	COc1ccc(NC(=O)\C=C/c2cn(nc2c3ccc(Br)cc3)c4ccccc4)cc1	10947983	IC50	=	5350	nM	5.27			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	827843	CHEMBL2051252	B	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62524	CHEMBL2046430	22705022	Bioorg. Med. Chem.	2012	20	14	4430			
CHEMBL2323290	1517447	CHEMBL2323290	1517447		5	478.59	1.44	195.14	0	CC(C)[C@@H]1NC(=O)Cn2cc(nn2)c3csc(CNC(=O)C[C@H](OC1=O)\C=C\CCS)n3	12659629	IC50	=	3880	nM	5.41			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	938235	CHEMBL2328538	B	Inhibition of C-terminal His-tagged full length human recombinant HDAC2 expressed in baculovirus expression system using fluorogenic acetylated peptide as substrate preincubated with enzyme for 10 mins prior to substrate addition measured after 60 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72033	CHEMBL2321647		ACS Med. Chem. Lett.	2013	4	1	132			
CHEMBL271949	435639	CHEMBL271949	435639		55	294.37	3.34	83.36	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3cccs3	2099197	IC50	=	360	nM	6.44			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	468835	CHEMBL947922	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38804	CHEMBL1143185	18182289	Bioorg. Med. Chem. Lett.	2008	18	3	973			
CHEMBL270149	436437	CHEMBL270149	436437		18	418.49	3.4	143.87	0	Nc1ccccc1NC(=O)c2ccc(CNc3nc(N)nc(NC4CCCC4)n3)cc2	2097985	Activity					Active		0	BAO_0000375			468079	CHEMBL931663	B	Activity against HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38730	CHEMBL1143113	18160287	Bioorg. Med. Chem. Lett.	2008	18	3	1067			
CHEMBL3309297	1778385	CHEMBL3309297	1778385		40	399.48	2.38	107.52	0	CC1(C)CC(=O)Nc2ccc(cc12)C(=O)NC[C@@H]3CC[C@H](CC3)\C=C\C(=O)NO	15053563	IC50	=	8.2	nM	8.09			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1450057	CHEMBL3373319	B	Inhibition of human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90190	CHEMBL3351757	24864038	Bioorg. Med. Chem.	2014	22	14	3720			
CHEMBL3309297	1778385	CHEMBL3309297	1778385		40	399.48	2.38	107.52	0	CC1(C)CC(=O)Nc2ccc(cc12)C(=O)NC[C@@H]3CC[C@H](CC3)\C=C\C(=O)NO	15053648	Ratio IC50	>	10					0	BAO_0000179			1450064	CHEMBL3373905	B	Potency index, ratio of IC50 for SAHA to IC50 for test compound against human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			90190	CHEMBL3351757	24864038	Bioorg. Med. Chem.	2014	22	14	3720			
CHEMBL271949	435639	CHEMBL271949	435639		3	294.37	3.34	83.36	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3cccs3	2116631	Activity	=	362	nM				0	BAO_0000181	UO_0000065	http://www.openphacts.org/units/Nanomolar	466096	CHEMBL934352	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38589	CHEMBL1142361	18304810	Bioorg. Med. Chem. Lett.	2008	18	6	1859			
CHEMBL3427751	1845147	CHEMBL3427751	1845147		2g	322.76	4.65	54.98	0	CCOC(=O)C1CCCc2c1[nH]nc2c3ccc(Cl)c(F)c3	15255901	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL337584	231631	CHEMBL337584	231631		TWZ 109	250.29	1.26	69.64	0	ON(CCCCCNC(=O)c1ccccc1)C=O	1289476	IC50	=	26000	nM	4.59			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	87875	CHEMBL697297	B	Inhibition of Histone deacetylase 2 (HDAC2) activity of HeLa nuclear extracts	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	6553	CHEMBL1137945	14698179	Bioorg. Med. Chem. Lett.	2004	14	2	449			
CHEMBL249198	416399	CHEMBL249198	416399		7l	400.47	3.19	96.89	0	COc1ccc(NC(=O)C(CCCCCC(=O)NO)OCc2ccccc2)cc1	2049600	Activity					Not Active		0	BAO_0000375			458150	CHEMBL925483	B	Inhibition of HDAC2 in HeLa cell lysates at 0.1 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL400482	416398	CHEMBL400482	416398		7k	448.51	4.95	96.89	0	ONC(=O)CCCCCC(Oc1cccc(Oc2ccccc2)c1)C(=O)Nc3ccccc3	2049601	Activity					Not Active		0	BAO_0000375			458150	CHEMBL925483	B	Inhibition of HDAC2 in HeLa cell lysates at 0.1 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL249198	416399	CHEMBL249198	416399		7l	400.47	3.19	96.89	0	COc1ccc(NC(=O)C(CCCCCC(=O)NO)OCc2ccccc2)cc1	2049517	IC50	=	500	nM	6.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL400482	416398	CHEMBL400482	416398		7k	448.51	4.95	96.89	0	ONC(=O)CCCCCC(Oc1cccc(Oc2ccccc2)c1)C(=O)Nc3ccccc3	2049518	IC50	=	500	nM	6.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL469275	488316	CHEMBL469275	488316		4	418.44	2.32	142.79	0	CC(C)(C)OC(=O)Nc1cccc(c1)c2onc(c2)C(=O)NCCCCC(=O)NO	2569577	IC50	=	2980	nM	5.53			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	514670	CHEMBL976442	B	Inhibition of HDAC2 after 17 hrs	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			44070	CHEMBL1155917	18642892	J. Med. Chem.	2008	51	15	4370			
CHEMBL2448576	1590724	CHEMBL2448576	1590724		32	477.6	3.86	100.21	0	CCC(=O)CCCCC[C@H](NC(=O)C1CN(C)C1)c2ncc([nH]2)c3cc4ccccc4nc3OC	2623795	IC50	=	18	nM	7.74			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	522846	CHEMBL1002514	B	Inhibition of human C-terminal FLAG-tagged HDAC2 in HEK293 cells	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46750	CHEMBL1136937	19441846	J. Med. Chem.	2009	52	11	3453	722	CHEMBL3307715	HEK293
CHEMBL1097745	626283	CHEMBL1097745	626283		15	344.43	4.25	83.36	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3csc4ccccc34	3286379	IC50	=	10000	nM	5			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1097745	626283	CHEMBL1097745	626283		15	344.43	4.25	83.36	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3csc4ccccc34	3286399	IC50	=	10000	nM	5			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL343717	232035	CHEMBL343717	232035		TWZ 111	300.35	2.17	69.64	0	ON(CCCCCNC(=O)c1ccc2ccccc2c1)C=O	1297746	IC50	=	1400	nM	5.85			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	87875	CHEMBL697297	B	Inhibition of Histone deacetylase 2 (HDAC2) activity of HeLa nuclear extracts	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	6553	CHEMBL1137945	14698179	Bioorg. Med. Chem. Lett.	2004	14	2	449			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	1302982	IC50	=	73	nM	7.14			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	87875	CHEMBL697297	B	Inhibition of Histone deacetylase 2 (HDAC2) activity of HeLa nuclear extracts	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	6553	CHEMBL1137945	14698179	Bioorg. Med. Chem. Lett.	2004	14	2	449			
CHEMBL2093007	1368196	CHEMBL2093007	1368196		74 Dimethyl FK-228	569.78	2.62	181.27	1	CSCC\C=C\[C@@H]1CC(=O)C[C@H](C(C)C)C(=O)N[C@H](CSC)C(=O)N\C(=C/C)\C(=O)N[C@@H](C(C)C)C(=O)O1	157538	IC50	=	3300	nM	5.48			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	87876	CHEMBL697298	B	Inhibitory concentration against human Histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	17295	CHEMBL1145900	14613312	J. Med. Chem.	2003	46	24	5097			
CHEMBL226556	377840	CHEMBL1182265	656215		10a	504.83	12.19	7.76	2	[Cl-].[I-].C=CCCCCCC[n+]1cccc(CCCCCCCCCCCC[n+]2cccc(CCCC=C)c2)c1	1861903	Activity					Not Active		0	BAO_0000375			434815	CHEMBL917043	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			35656	CHEMBL1139873	17447750	J. Med. Chem.	2007	50	10	2497			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	2489473	IC50	=	10	nM	8			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	515266	CHEMBL991290	B	Inhibition of human recombinant histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45582	CHEMBL1143301	19111466	Bioorg. Med. Chem. Lett.	2009	19	3	688			
CHEMBL516600	473678	CHEMBL516600	473678		7c	387.43	3.44	81.67	0	ONC(=O)c1ccc(CN2[C@@H](Cc3ccccc3)C(=O)Nc4ccccc24)cc1	2489476	IC50	=	460	nM	6.34			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	515266	CHEMBL991290	B	Inhibition of human recombinant histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45582	CHEMBL1143301	19111466	Bioorg. Med. Chem. Lett.	2009	19	3	688			
CHEMBL480729	474724	CHEMBL480729	474724		7i	468.55	3.4	120	0	CC(C)(C)OC(=O)NCCCC[C@H]1N(Cc2ccc(cc2)C(=O)NO)c3ccccc3NC1=O	2489482	IC50	=	1480	nM	5.83			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	515266	CHEMBL991290	B	Inhibition of human recombinant histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45582	CHEMBL1143301	19111466	Bioorg. Med. Chem. Lett.	2009	19	3	688			
CHEMBL521431	474786	CHEMBL521431	474786		7j	459.54	4.35	90.9	0	CC(C)(C)Oc1ccc(C[C@H]2N(Cc3ccc(cc3)C(=O)NO)c4ccccc4NC2=O)cc1	2489483	IC50	=	1440	nM	5.84			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	515266	CHEMBL991290	B	Inhibition of human recombinant histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45582	CHEMBL1143301	19111466	Bioorg. Med. Chem. Lett.	2009	19	3	688			
CHEMBL481718	474787	CHEMBL481718	474787		12a	353.37	.96	98.74	0	ONC(=O)c1ccc(CN2[C@H](Cc3ccccc3)C(=O)NCC2=O)cc1	2489484	IC50	=	5540	nM	5.26			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	515266	CHEMBL991290	B	Inhibition of human recombinant histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45582	CHEMBL1143301	19111466	Bioorg. Med. Chem. Lett.	2009	19	3	688			
CHEMBL454438	519579	CHEMBL454438	519579		13c	336.41	.65	122.56	0	NS(=O)(=O)NCCCCCC(=O)Nc1ccc2ncccc2c1	2600493	Activity					Not Active		0	BAO_0000375			540708	CHEMBL1027321	B	Inhibition of human recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus by fluorimetry	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			46637	CHEMBL1149076	19084395	Bioorg. Med. Chem. Lett.	2009	19	2	336			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	1, TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	3480808	IC50	=	10	nM	8			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	672869	CHEMBL1267844	B	Inhibition of HDAC2 by in vitro deacetylation assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			53324	CHEMBL1255383	19966789	Nat. Chem. Biol.	2010	6	1	25			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	2, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	3480809	IC50	=	400	nM	6.4			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	672869	CHEMBL1267844	B	Inhibition of HDAC2 by in vitro deacetylation assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			53324	CHEMBL1255383	19966789	Nat. Chem. Biol.	2010	6	1	25			
CHEMBL2414098	1575330	CHEMBL2414098	1575330		11e, T009	340.22	3.41	78.01	0	ONC(=O)CCCCCCc1nc2ccc(Br)cc2[nH]1	13403354	IC50	=	34.1	nM	7.47			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	977418	CHEMBL2417305	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74587	CHEMBL2413017	23906422	Bioorg. Med. Chem. Lett.	2013	23	17	4790			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	13297516	Inhibition					Active		0	BAO_0000376			958690	CHEMBL2383992	B	Inhibition of HDAC2 in human HeLa cells assessed as increase in histone H3 acetylation at 10 uM after 48 hrs by Western blotting analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			73668	CHEMBL2380312	23672185	J. Med. Chem.	2013	56	11	4816	308	CHEMBL3308376	HeLa
CHEMBL2381524	1560934	CHEMBL2381524	1560934		10	282.29	2.1	78.43	0	ONC(=O)c1cccc(\C=C\C(=O)Nc2ccccc2)c1	13297517	Inhibition					Active		0	BAO_0000376			958690	CHEMBL2383992	B	Inhibition of HDAC2 in human HeLa cells assessed as increase in histone H3 acetylation at 10 uM after 48 hrs by Western blotting analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			73668	CHEMBL2380312	23672185	J. Med. Chem.	2013	56	11	4816	308	CHEMBL3308376	HeLa
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	13297580	IC50	=	18	nM	7.74			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	958899	CHEMBL2384807	B	Inhibition of HDAC2 (unknown origin) after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	73668	CHEMBL2380312	23672185	J. Med. Chem.	2013	56	11	4816			
CHEMBL2381524	1560934	CHEMBL2381524	1560934		10	282.29	2.1	78.43	0	ONC(=O)c1cccc(\C=C\C(=O)Nc2ccccc2)c1	13297581	IC50	=	4800	nM	5.32			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	958899	CHEMBL2384807	B	Inhibition of HDAC2 (unknown origin) after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	73668	CHEMBL2380312	23672185	J. Med. Chem.	2013	56	11	4816			
CHEMBL2381520	1560930	CHEMBL2381520	1560930		6	256.26	1.63	78.43	0	ONC(=O)c1cccc(c1)C(=O)Nc2ccccc2	13297585	IC50	=	30000	nM	4.52			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	958899	CHEMBL2384807	B	Inhibition of HDAC2 (unknown origin) after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	73668	CHEMBL2380312	23672185	J. Med. Chem.	2013	56	11	4816			
CHEMBL2381519	1560929	CHEMBL2381519	1560929		5	270.28	1.64	78.43	0	ONC(=O)c1cccc(c1)C(=O)NCc2ccccc2	13297586	IC50	=	11000	nM	4.96			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	958899	CHEMBL2384807	B	Inhibition of HDAC2 (unknown origin) after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	73668	CHEMBL2380312	23672185	J. Med. Chem.	2013	56	11	4816			
CHEMBL94394	153408	CHEMBL94394	153408	BUFEXAMAC	bufexamac	223.27	2.19	58.56	0	CCCCOc1ccc(CC(=O)NO)cc1	13431337	Kd	>	1000000	nM			Outside typical range	0	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	977749	CHEMBL2424296	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74749	CHEMBL2417402	23627282	J. Med. Chem.	2013	56	16	6297			
CHEMBL2417784	1576548	CHEMBL2417784	1576548		12	375.49	2.66	123.02	0	C[C@@H](S)C(=O)NCCCCCNC(=O)c1c(C)onc1c2ccccc2	13431350	IC50	>	30000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	977749	CHEMBL2424296	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74749	CHEMBL2417402	23627282	J. Med. Chem.	2013	56	16	6297			
CHEMBL2417783	1576547	CHEMBL2417783	1576547		11	361.46	2.17	123.02	0	Cc1onc(c2ccccc2)c1C(=O)NCCCCCNC(=O)CS	13431356	IC50	=	28000	nM	4.55			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	977749	CHEMBL2424296	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74749	CHEMBL2417402	23627282	J. Med. Chem.	2013	56	16	6297			
CHEMBL2417781	1576545	CHEMBL2417781	1576545		7	452.55	2.71	119.56	0	ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)c2ccccc2NC(=O)[C@@H]3CCCN3	13431371	IC50	=	193	nM	6.71			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	977740	CHEMBL2424287	B	Inhibition of His-6-tagged full length HDAC2 (unknown origin) expressed in sf9 cells using carboxyfluorescein (FAM)-labeled acetylated peptide as substrate after 17 hrs by fluorescence-based electrophoretic assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74749	CHEMBL2417402	23627282	J. Med. Chem.	2013	56	16	6297			
CHEMBL2425971	1581090	CHEMBL2425971	1581090		5b	427.5	4.6	82	0	CCC1=Nc2cc(Cc3ccc(cc3)C(=O)NO)ccc2C(=O)N1CCc4ccccc4	13451910	IC50					Not Determined		0	BAO_0000190			983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL2425969	1581088	CHEMBL2425969	1581088		4c	397.85	3.75	82	0	CCC1=Nc2cc(Cl)c(\C=C\C(=O)NO)cc2C(=O)N1CCc3ccccc3	13451912	IC50	>	12000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL2425961	1581080	CHEMBL2425961	1581080		3i	363.41	3.09	82	0	CCC1=Nc2cc(\C=C\C(=O)NO)ccc2C(=O)N1CCc3ccccc3	13451920	IC50	=	4810	nM	5.32			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL2425960	1581079	CHEMBL2425960	1581079		3h	335.36	2.34	82	0	ONC(=O)\C=C\c1ccc2C(=O)N(CCc3ccccc3)C=Nc2c1	13451921	IC50	=	1220	nM	5.91			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL2425958	1581077	CHEMBL2425958	1581077		3f	349.38	2.42	82	0	CC1=Nc2cc(\C=C\C(=O)NO)ccc2C(=O)N1CCc3ccccc3	13451923	IC50	=	6450	nM	5.19			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	13451926	IC50	=	5	nM	8.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL1767043	1142082	CHEMBL1767043	1142082		32	387.43	1.93	142.84	0	CNC(=O)\C(=N\O)\CCCCCCNC(=O)c1cc(on1)c2cccc(N)c2	6174079	IC50	=	33000	nM	4.48			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL1771484	1143795	CHEMBL1771484	1143795		A14B3	345.39	3.25	100.02	0	ONC(=O)CCCCCCC(=O)N\N=C\c1ccc(OCC#C)cc1	6182567	IC50	=	2.1	nM	8.68			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	744275	CHEMBL1772082	B	Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			57403	CHEMBL1770095	21334896	Bioorg. Med. Chem. Lett.	2011	21	9	2601			
CHEMBL468527	479451	CHEMBL468527	479451		12	379.41	3.3	104.46	0	ONC(=O)c1cc(CCCCC(=O)Nc2ccc(cc2)c3ccccc3)on1	2641985	IC50	=	3750	nM	5.43			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	500548	CHEMBL971413	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46730	CHEMBL1136917	19419863	Bioorg. Med. Chem. Lett.	2009	19	11	3023			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	1, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	2637847	IC50	=	82	nM	7.09			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	500776	CHEMBL971455	B	Inhibition of C-terminal FLAG tagged HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			46717	CHEMBL1136904	19410459	Bioorg. Med. Chem. Lett.	2009	19	11	3081			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	3,SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	3341232	IC50	=	210	nM	6.68			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	639020	CHEMBL1166158	B	Inhibition of HDAC2 after 10 mins by fluorometric assay	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51523	CHEMBL1165922	20452225	Bioorg. Med. Chem.	2010	18	11	4119			
CHEMBL27759	36237	CHEMBL27759	36237	ENTINOSTAT	SNDX-275	376.41	2.07	106.33	0	Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2	5122781	IC50	=	1000	nM	6			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	700124	CHEMBL1647006	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			54702	CHEMBL1641604	21145737	Bioorg. Med. Chem. Lett.	2011	21	1	110			
CHEMBL1767040	1142079	CHEMBL1767040	1142079		24	466.96	4.08	103.68	0	CNC(=O)\C(=N/O)\CCCCCCC(=O)Nc1cccc(c1)c2cncc3cc(Cl)ccc23	6174076	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL1767044	1142083	CHEMBL1767044	1142083		33	387.43	1.93	142.84	0	CNC(=O)\C(=N\O)\CCCCCCNC(=O)c1cc(on1)c2ccc(N)cc2	6174080	IC50	=	48100	nM	4.32			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL1767036	1142075	CHEMBL1767036	1142075		20	381.47	3.66	90.79	0	CNC(=O)\C(=N/O)\CCCCCCC(=O)Nc1cccc(c1)c2ccccc2	6174072	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA, vorinostat	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	6273616	IC50	=	24	nM	7.62			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	755404	CHEMBL1804720	B	Inhibition of human recombinant HDAC2 using fluor de Lys as substrate by fluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	58134	CHEMBL1800056	21080647	J. Med. Chem.	2010	53	24	8663			
CHEMBL1801250	1162323	CHEMBL1801250	1162323		21r, CHR-3996	394.4	1.13	103.27	0	ONC(=O)c1cnc(nc1)N2C[C@@H]3[C@H](C2)[C@H]3NCc4ccc5cc(F)ccc5n4	6273617	IC50	=	4	nM	8.4			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	755404	CHEMBL1804720	B	Inhibition of human recombinant HDAC2 using fluor de Lys as substrate by fluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	58134	CHEMBL1800056	21080647	J. Med. Chem.	2010	53	24	8663			
CHEMBL1800380	1161444	CHEMBL1800380	1161444		27	214.24	1.4	97.61	0	COC(=O)CSc1nc(C)cc(O)n1	6283050	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL1800381	1161445	CHEMBL1800381	1161445		28	198.24	1.28	88.38	0	CC(=O)CSc1nc(C)cc(O)n1	6283051	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL1830396	1177102	CHEMBL1830396	1177102		10e	344.45	3.2	79.18	0	CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCNC(C)C	6370655	Ki	=	33	nM	7.48			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	769058	CHEMBL1832521	B	Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58940	CHEMBL1828590	21634430	J. Med. Chem.	2011	54	13	4694			
CHEMBL1830422	1177128	CHEMBL1830422	1177128		10q	372.5	4.12	79.18	0	CCCCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCNC(C)C	6370658	Ki	=	18	nM	7.74			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	769058	CHEMBL1832521	B	Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58940	CHEMBL1828590	21634430	J. Med. Chem.	2011	54	13	4694			
CHEMBL1478462	902346	CHEMBL1478462	902346		TM-2-90	270.35	3.5	73.22	0	O=C(NC(=S)NCc1ccccc1)c2ccccc2	6377075	Activity					Not Active		0	BAO_0000375			771836	CHEMBL1838708	B	Activation of HDAC2 using Fluor-de-Lys as substrate at 10 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1478462	902346	CHEMBL1478462	902346		TM-2-90	270.35	3.5	73.22	0	O=C(NC(=S)NCc1ccccc1)c2ccccc2	6376315	Activity					Not Active		0	BAO_0000375			771829	CHEMBL1838701	B	Activation of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1478462	902346	CHEMBL1478462	902346		TM-2-90	270.35	3.5	73.22	0	O=C(NC(=S)NCc1ccccc1)c2ccccc2	6376227	Inhibition					Not Active		0	BAO_0000376			771822	CHEMBL1838694	B	Inhibition of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1957458	1282989	CHEMBL1957458	1282989		8b	491.56	2.18	153.07	0	CCN1CCN(C(=O)NCc2ccc(cc2)C(=O)Nc3cc(ccc3N)c4cccs4)C(=O)C1=O	8048588	IC50	=	670	nM	6.17			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	807676	CHEMBL1959441	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			61262	CHEMBL1955769	22321215	Bioorg. Med. Chem. Lett.	2012	22	5	1926			
CHEMBL1957458	1282989	CHEMBL1957458	1282989		8b	491.56	2.18	153.07	0	CCN1CCN(C(=O)NCc2ccc(cc2)C(=O)Nc3cc(ccc3N)c4cccs4)C(=O)C1=O	8048603	Inhibition					Active		0	BAO_0000376			807673	CHEMBL1959438	B	Inhibition of HDAC2 in human HCT116 cells assessed as hyperacetylation of histone H3 at 10 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			61262	CHEMBL1955769	22321215	Bioorg. Med. Chem. Lett.	2012	22	5	1926			
CHEMBL1800378	1161442	CHEMBL1800378	1161442		25	315.35	1.94	117.47	0	Cc1cc(O)nc(SCC(=O)c2ccc3CC(=O)Nc3c2)n1	6283048	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL1555726	979610	CHEMBL1555726	979610		TM-2-97	262.37	3.77	73.22	0	O=C(NC(=S)NC1CCCCC1)c2ccccc2	6376225	Inhibition					Not Active		0	BAO_0000376			771822	CHEMBL1838694	B	Inhibition of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1834364	1178408	CHEMBL1834364	1178408		TM-2-88	316.37	3.73	91.68	0	COc1cc(NC(=S)NC(=O)c2ccccc2)cc(OC)c1	6376231	Inhibition	=	6	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	771822	CHEMBL1838694	B	Inhibition of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1555726	979610	CHEMBL1555726	979610		TM-2-97	262.37	3.77	73.22	0	O=C(NC(=S)NC1CCCCC1)c2ccccc2	6377073	Activity					Not Active		0	BAO_0000375			771836	CHEMBL1838708	B	Activation of HDAC2 using Fluor-de-Lys as substrate at 10 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1555726	979610	CHEMBL1555726	979610		TM-2-97	262.37	3.77	73.22	0	O=C(NC(=S)NC1CCCCC1)c2ccccc2	6376313	Activity					Not Active		0	BAO_0000375			771829	CHEMBL1838701	B	Activation of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL2170174	1429655	CHEMBL2170174	1429655		1i	571.63	7.37	173.36	2	COc1cc(COc2ccc(NC(=O)CCCCCCC(=O)OCc3ccc(CN=[N+]=[N-])cc3)cc2)cc(c1)N=[N+]=[N-]	12114356	Inhibition					Dose-dependent effect		0	BAO_0000376			864742	CHEMBL2175009	B	Inhibition of nuclear HDAC2 in human SH-SY5Y cells assessed as increase in histone H4 acetylation after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			66025	CHEMBL2169804	23010266	Bioorg. Med. Chem. Lett.	2012	22	21	6621			
CHEMBL2170174	1429655	CHEMBL2170174	1429655		1i	571.63	7.37	173.36	2	COc1cc(COc2ccc(NC(=O)CCCCCCC(=O)OCc3ccc(CN=[N+]=[N-])cc3)cc2)cc(c1)N=[N+]=[N-]	12114358	IC50	=	79000	nM	4.1			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	864740	CHEMBL2175007	B	Inhibition of human recombinant HDAC2 using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by microplate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	66025	CHEMBL2169804	23010266	Bioorg. Med. Chem. Lett.	2012	22	21	6621			
CHEMBL2333340	1522978	CHEMBL2333340	1522978		4	284.31	1.96	78.43	0	ONC(=O)c1ccc(cc1)C(=O)NCCc2ccccc2	12680998	IC50	=	607	nM	6.22			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	944722	CHEMBL2340968	B	Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772			
CHEMBL2381522	1560932	CHEMBL2381522	1560932		8	151.16	1.33	49.33	0	Cc1cccc(c1)C(=O)NO	13297583	IC50	>	33000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	958899	CHEMBL2384807	B	Inhibition of HDAC2 (unknown origin) after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			73668	CHEMBL2380312	23672185	J. Med. Chem.	2013	56	11	4816			
CHEMBL3220922	1727327	CHEMBL3220922	1727327		1, DUAL946	552.66	3.63	137.07	1	CC(C)OC(=O)N[C@@H]1C[C@H](C)N(C(=O)C)c2ccc(cc12)c3ccc(NC(=O)CCCCCCC(=O)NO)cc3	14529956	Kd	=	955	nM	6.02			0	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	1329068	CHEMBL3224054	B	Binding affinity to HDAC2 in human HL60 cell nuclear extracts assessed as inhibition of enzyme binding to N-SAHA functionalised sepharose beads after 1 hr by coomassie staining-based chemoproteomic competition binding assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82037	CHEMBL3217474		MedChemComm	2014	5	3	342			
CHEMBL3356925	1821068	CHEMBL3356925	1821068		45, ST7541	439.57	2.92	126.1	0	SCCCCC[C@H](NC(=O)[C@H]1[C@@H](CNC1=O)c2ccccc2)C(=O)Nc3ccccc3	15138229	IC50	=	37	nM	7.43			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3352992	1817095	CHEMBL3352992	1817095		6c	539.62	1.77	169.48	2	CC(C)[C@H]1NC(=O)C[C@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](C)NC1=O)\C=C\CCCC(=O)O	15126324	Ki	=	400	nM	6.4			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	1440125	CHEMBL3382538	B	Inhibition of human recombinant HDAC2 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89689	CHEMBL3351463	25380299	J. Med. Chem.	2014	57	22	9644			
CHEMBL3317818	1782457	CHEMBL3317818	1782457		11	634.79	2.56	246.2	2	CC(C)(C)OC(=O)n1cnc(C[C@@H]2NC(=O)[C@]3(C)CSC(=N3)c4csc(CNC(=O)C[C@H](OC2=O)\C=C\CCS)n4)c1	15060234	IC50	=	1.1	nM	8.96			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1452234	CHEMBL3366146	B	Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90621	CHEMBL3352389	25070421	Bioorg. Med. Chem. Lett.	2014	24	16	3728			
CHEMBL3427745	1845141	CHEMBL3427745	1845141		4b	289.76	3.45	57.78	0	CNC(=O)C1CCCc2c1[nH]nc2c3ccc(Cl)cc3	15255896	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL3427756	1845152	CHEMBL3427756	1845152		3l	309.29	3.52	71.77	0	NC(=O)C1CCCc2c1[nH]nc2c3ccc(cc3)C(F)(F)F	15255906	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL3427762	1845158	CHEMBL3427762	1845158		3r	294.35	3.37	76.69	0	Cn1c(cc2ccccc12)c3n[nH]c4C(CCCc34)C(=O)N	15255970	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL3221535	1727946	CHEMBL3221535	1727946		8	585.76	-1.28	232.71	2	CC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCNC(=S)C)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C)C(=O)N	14535127	Activity	=	19	%				0	BAO_0001103	UO_0000187	http://qudt.org/vocab/unit#Percent	1328677	CHEMBL3226304	B	Activity of HDAC2 in human HeLa cells nuclear extract assessed as compound deacetylation measured up to 2 hrs by time course assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			81713	CHEMBL3217699		MedChemComm	2010	1	3	233			
CHEMBL141885	231665	CHEMBL141885	231665		TWZ 110	278.35	1.75	69.64	0	ON(CCCCCNC(=O)CCc1ccccc1)C=O	1276794	IC50	=	41000	nM	4.39			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	87875	CHEMBL697297	B	Inhibition of Histone deacetylase 2 (HDAC2) activity of HeLa nuclear extracts	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	6553	CHEMBL1137945	14698179	Bioorg. Med. Chem. Lett.	2004	14	2	449			
CHEMBL398884	423409	CHEMBL398884	423409		1	295.36	3.84	77.56	0	Oc1ccc(cc1NC(=O)c2cccs2)c3ccccc3	2073911	Activity					Not Determined		0	BAO_0000375			461756	CHEMBL927762	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38240	CHEMBL1140803	18060775	Bioorg. Med. Chem. Lett.	2008	18	2	726			
CHEMBL1812335	1167357	CHEMBL1812335	1167357		4	335.23	3.32	46.33	0	N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N2Cc3ccccc3C2	6314706	IC50	=	3900	nM	5.41			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	761695	CHEMBL1816687	B	Inhibition of human HDAC2 using rhodamine as substrate after 1 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	58554	CHEMBL1811912	21723733	Bioorg. Med. Chem.	2011	19	15	4626			
CHEMBL3098697	1609468	CHEMBL3098697	1609468		15	396.48	.68	136.63	0	ONC(=O)CCCCC[C@H](NC(=O)[C@@H]1CCCC(=O)N1)C(=O)NC2CCCC2	13867804	IC50	=	5040	nM	5.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL248819	416510	CHEMBL248819	416510		4g	386.44	2.74	96.89	0	COc1ccc(COC(CCCCC(=O)NO)C(=O)Nc2ccccc2)cc1	2049595	Activity					Not Active		0	BAO_0000375			458150	CHEMBL925483	B	Inhibition of HDAC2 in HeLa cell lysates at 0.1 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL491316	457921	CHEMBL491316	457921		2, SB639	404.5	4.05	70.39	0	ONC(=O)\C=C\c1ccc2c(c1)nc(CCc3ccccc3)n2CCN4CCCC4	6370651	Ki	=	36	nM	7.44			1	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	769058	CHEMBL1832521	B	Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58940	CHEMBL1828590	21634430	J. Med. Chem.	2011	54	13	4694			
CHEMBL251819	423539	CHEMBL251819	423539		2	379.48	3.13	112.46	0	CCC(=O)NCc1ccc(cc1)C(=O)Nc2cc(ccc2N)c3cccs3	8048586	IC50	=	470	nM	6.33			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	807676	CHEMBL1959441	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			61262	CHEMBL1955769	22321215	Bioorg. Med. Chem. Lett.	2012	22	5	1926			
CHEMBL251819	423539	CHEMBL251819	423539		2	379.48	3.13	112.46	0	CCC(=O)NCc1ccc(cc1)C(=O)Nc2cc(ccc2N)c3cccs3	8048602	Inhibition					Active		0	BAO_0000376			807673	CHEMBL1959438	B	Inhibition of HDAC2 in human HCT116 cells assessed as hyperacetylation of histone H3 at 10 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			61262	CHEMBL1955769	22321215	Bioorg. Med. Chem. Lett.	2012	22	5	1926			
CHEMBL343448	246935	CHEMBL343448	246935	DEPSIPEPTIDE	2, FK228	540.7	1.69	193.29	1	C\C=C\1/NC(=O)[C@H]2CSSCC\C=C\[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@@H](NC1=O)C(C)C	10981401	IC50	=	1	nM	9			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	831128	CHEMBL2065941	B	Inhibition of recombinant HDAC2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			62769	CHEMBL2062402		ACS Med. Chem. Lett.	2012	3	6	505			
CHEMBL2048751	1352186	CHEMBL2048751	1352186		13	360.36	3.17	96.78	0	ONC(=O)\C=C\c1ccc2c(ccn2S(=O)(=O)c3ccc(F)cc3)c1	10948227	IC50	=	199.4	nM	6.7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	826885	CHEMBL2051700	B	Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62425	CHEMBL2046324	22439863	J. Med. Chem.	2012	55	8	3777			
CHEMBL2425956	1581075	CHEMBL2425956	1581075		3d	321.33	2.09	82	0	CC1=Nc2c(\C=C\C(=O)NO)cccc2C(=O)N1c3ccccc3	13451927	IC50	>	10000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL237370	399236	CHEMBL237370	399236	CINNAMIC ACID HYDROXAMATE	4, BOTI	232.06	2.64	49.33	0	ONC(=O)\C=C\c1ccc(Cl)cc1Cl	13488735	Inhibition					Active		0	BAO_0000376			987733	CHEMBL2439711	B	Inhibition of HDAC2 (unknown origin)-mediated deacetylation at 10 uM preincubated for 5 mins prior to substrate addition measured after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75182	CHEMBL2434956	24074025	J. Med. Chem.	2013	56	20	7997			
CHEMBL3110021	1615227	CHEMBL3110021	1615227		31	320.34	2.21	75.36	0	ONC(=O)[C@@H]1[C@@H]([C@H]1c2ccc(cc2)c3ocnc3)c4ccccc4	13896925	IC50	=	43000	nM	4.37			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1287880	CHEMBL3112164	B	Inhibition of human recombinant full length HDAC2 using (Ac)Arg-Gly-Lys(Ac) as substrate after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76664	CHEMBL3108758	24261862	J. Med. Chem.	2013	56	24	9934			
CHEMBL3098602	1609372	CHEMBL3098602	1609372		28, ST8078AA1	458.43	1.34	136.63	0	ONC(=O)CCCCC[C@H](NC(=O)[C@H]1CCC(=O)N1)C(=O)Nc2cccc(c2)C(F)(F)F	13867802	IC50	=	8	nM	8.1			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL3356527	1820666	CHEMBL3356527	1820666		51, ST7539	377.5	2.03	126.1	0	SCCCCC[C@H](NC(=O)[C@@H]1CCCNC1=O)C(=O)Nc2ccccc2	15138241	IC50	=	28	nM	7.55			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3356526	1820665	CHEMBL3356526	1820665		82, ST8013	391.53	2.25	117.31	0	CN1[C@@H](CCCC1=O)C(=O)N[C@@H](CCCCCS)C(=O)Nc2ccccc2	15138242	IC50	=	70	nM	7.15			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3098602	1609372	CHEMBL3098602	1609372		7	458.43	1.34	136.63	0	ONC(=O)CCCCC[C@H](NC(=O)[C@H]1CCC(=O)N1)C(=O)Nc2cccc(c2)C(F)(F)F	14976176	IC50	=	8	nM	8.1			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1444620	CHEMBL3376039	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90082	CHEMBL3352629	25563890	Bioorg. Med. Chem. Lett.	2015	25	3	459			
CHEMBL1958436	1283977	CHEMBL1958436	1283977		15	336.34	2.01	103.88	0	ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)Nc2cccc(F)c2	8054630	ED50	=	221	nM			Non standard unit for type	0	BAO_0003036	UO_0000065	http://www.openphacts.org/units/Nanomolar	808465	CHEMBL1961041	B	Inhibition of human recombinant HDAC2 expressed using baculovirus expression system using Flour- De-Lys as substrate after 3 hrs by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			61278	CHEMBL1955831	22326398	Bioorg. Med. Chem. Lett.	2012	22	5	1886			
CHEMBL1643308	1057866	CHEMBL1643308	1057866		5q	567.6	3.41	108.72	1	Nc1ccccc1NC(=O)\C=C\c2ccc(cc2)C(NCCN3CCOCC3)C(=O)Nc4ccc(cc4)C(F)(F)F	5122778	IC50	=	290	nM	6.54			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	700124	CHEMBL1647006	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			54702	CHEMBL1641604	21145737	Bioorg. Med. Chem. Lett.	2011	21	1	110			
CHEMBL3356934	1821077	CHEMBL3356934	1821077		17, ST7819	357.51	4.76	77.13	0	SCCCCCCC(=O)NCc1cccc(OCc2ccccc2)c1	15138289	IC50	=	14000	nM	4.85			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL561209	559437	CHEMBL561209	559437		1c	269.3	2.81	58.56	0	COc1ccc(cc1)c2ccc(\C=C\C(=O)NO)cc2	14570746	IC50	=	1160	nM	5.94			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1335247	CHEMBL3238600	B	Inhibition of HDAC2 in human HeLa cells using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82343	CHEMBL3232764	24742384	Eur. J. Med. Chem.	2014	79		251			
CHEMBL561209	559437	CHEMBL561209	559437		3g	269.3	2.81	58.56	0	COc1ccc(cc1)c2ccc(\C=C\C(=O)NO)cc2	2657776	IC50	=	1160	nM	5.94			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL399388	399326	CHEMBL399388	399326		12	459.56	4.41	113.85	0	COc1ccc(NCc2ccc(cc2)C(=O)Nc3cc(ccc3N)c4ccsc4)cc1OC	1998274	IC50	=	60	nM	7.22			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL399388	399326	CHEMBL399388	399326		12	459.56	4.41	113.85	0	COc1ccc(NCc2ccc(cc2)C(=O)Nc3cc(ccc3N)c4ccsc4)cc1OC	1998352	Inhibition	<	50	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	451049	CHEMBL900130	B	Inhibition of human recombinant HDAC2 at 20 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL248797	416393	CHEMBL248797	416393		7h	400.47	3.19	96.89	0	COc1cccc(COC(CCCCCC(=O)NO)C(=O)Nc2ccccc2)c1	2049528	IC50	>=	50	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL442426	416402	CHEMBL442426	416402		10c	334.41	2.7	87.66	0	ONC(=O)CCCCCCC(OCC=C)C(=O)Nc1ccccc1	2049605	Activity					Active		0	BAO_0000375			458150	CHEMBL925483	B	Inhibition of HDAC2 in HeLa cell lysates at 0.1 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL442426	416402	CHEMBL442426	416402		10c	334.41	2.7	87.66	0	ONC(=O)CCCCCCC(OCC=C)C(=O)Nc1ccccc1	2049526	IC50	>=	50	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL272401	440127	CHEMBL272401	440127		78m	442.62	4.02	102.57	0	CN1CCCCC1N[C@@H](CCCCCC(=O)C)C(=O)Nc2nc(cs2)c3ccccc3	2106148	IC50	=	170	nM	6.77			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	464924	CHEMBL946981	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38494	CHEMBL1142268	18247554	J. Med. Chem.	2008	51	6	1505			
CHEMBL235842	399341	CHEMBL235842	399341		82b	351.42	2.46	112.46	0	CC(=O)Nc1ccc(cc1)C(=O)Nc2cc(ccc2N)c3cccs3	2106225	IC50	=	100	nM	7			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	464924	CHEMBL946981	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38494	CHEMBL1142268	18247554	J. Med. Chem.	2008	51	6	1505			
CHEMBL235842	399341	CHEMBL235842	399341		60	351.42	2.46	112.46	0	CC(=O)Nc1ccc(cc1)C(=O)Nc2cc(ccc2N)c3cccs3	2099207	IC50	=	49	nM	7.31			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	468835	CHEMBL947922	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38804	CHEMBL1143185	18182289	Bioorg. Med. Chem. Lett.	2008	18	3	973			
CHEMBL487107	508481	CHEMBL487107	508481		14d	530.41	3.82	129.37	1	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)c2cnnn2CC(O)c3cccc(Br)c3	2351854	IC50	=	116	nM	6.94			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL1099078	626205	CHEMBL1099078	626205		11	330.38	3.13	72.19	0	CC(=O)c1ccc(cc1)c2ccc(N)c(NC(=O)c3ccccc3)c2	3286434	Ratio IC50	=	1.3					0	BAO_0000179			630933	CHEMBL1116532	B	Selectivity ratio of IC50 for human recombinant HDAC2 preincubated for 1 hr with substrate to IC50 for human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1096397	626135	CHEMBL1096397	626135		6	314.38	3.94	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccc(C=C)cc3	3286368	Ratio IC50	=	6					0	BAO_0000179			630933	CHEMBL1116532	B	Selectivity ratio of IC50 for human recombinant HDAC2 preincubated for 1 hr with substrate to IC50 for human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1099078	626205	CHEMBL1099078	626205		11	330.38	3.13	72.19	0	CC(=O)c1ccc(cc1)c2ccc(N)c(NC(=O)c3ccccc3)c2	3286383	IC50	=	3800	nM	5.42			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1096397	626135	CHEMBL1096397	626135		6	314.38	3.94	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccc(C=C)cc3	3286388	IC50	=	800	nM	6.1			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1099078	626205	CHEMBL1099078	626205		11	330.38	3.13	72.19	0	CC(=O)c1ccc(cc1)c2ccc(N)c(NC(=O)c3ccccc3)c2	3286403	IC50	=	5000	nM	5.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1096397	626135	CHEMBL1096397	626135		6	314.38	3.94	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccc(C=C)cc3	3286408	IC50	=	5000	nM	5.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1163778	645854	CHEMBL1163778	645854		20b	419.6	4.2	89.79	0	C[C@H](CCCCC(=O)NO)[C@H]1CC[C@H]2\C(=C\C=C3C[C@@H](O)C[C@H](O)C3)\CCC[C@]12C	3341234	IC50	=	16500	nM	4.78			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	639020	CHEMBL1166158	B	Inhibition of HDAC2 after 10 mins by fluorometric assay	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51523	CHEMBL1165922	20452225	Bioorg. Med. Chem.	2010	18	11	4119			
CHEMBL1771315	1143625	CHEMBL1771315	1143625		A12B4	283.28	1.7	90.79	0	ONC(=O)c1cccc(c1)C(=O)N\N=C\c2ccccc2	6182566	IC50	=	20000	nM	4.7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	744275	CHEMBL1772082	B	Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			57403	CHEMBL1770095	21334896	Bioorg. Med. Chem. Lett.	2011	21	9	2601			
CHEMBL1800385	1161449	CHEMBL1800385	1161449		33	359.49	4.48	100.41	0	Cc1cc(O)nc(SCC(=O)NCCCCCCc2ccccc2)n1	6283056	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL387924	382037	CHEMBL387924	382037		10	392.43	2.84	165.37	0	ONC(=O)CCCCCCC(=O)Nc1nc(cs1)c2cccc(c2)[N+](=O)[O-]	1902508	IC50	=	113	nM	6.95			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	439074	CHEMBL889422	B	Inhibition of His-tagged HDAC2 expressed in Sf9 cells by fluorescence-based assay	1	Scientific Literature				Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			36060	CHEMBL1145385	17539623	J. Med. Chem.	2007	50	13	3054	1759	CHEMBL3308860	Sf9
CHEMBL235191	399340	CHEMBL235191	399340	TACEDINALINE	18, pfizer,CI-994	269.3	.99	84.22	0	CC(=O)Nc1ccc(cc1)C(=O)Nc2ccccc2N	1998288	IC50	=	900	nM	6.05			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL250005	416401	CHEMBL250005	416401		7m	430.49	3.18	106.12	0	COc1ccc(COC(CCCCCC(=O)NO)C(=O)Nc2ccc(OC)cc2)cc1	2049516	IC50	=	500	nM	6.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL520056	508480	CHEMBL520056	508480		14c	407.47	3.57	109.14	0	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)c2cnnn2c3ccccc3	2351855	IC50	=	167	nM	6.78			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL487742	508421	CHEMBL487742	508421		12c	407.47	3.57	109.14	0	ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)c2cnnn2c3ccccc3	2351859	IC50	=	146	nM	6.84			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL487741	508420	CHEMBL487741	508420		12b	439.48	3.79	109.14	0	ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)c2cnnn2Cc3ccc(F)cc3	2351860	IC50	=	57.4	nM	7.24			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL396097	410986	CHEMBL396097	410986		6	227.26	2.37	49.33	0	ONC(=O)C(c1ccccc1)c2ccccc2	2922894	Inhibition					Not Active		0	BAO_0000376			592005	CHEMBL1050120	B	Inhibition of recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus at 20 uM after 10 mins by fluorimetric analysis	1	Scientific Literature				Intermediate	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			48688	CHEMBL1155182	19699639	Bioorg. Med. Chem. Lett.	2009	19	19	5684			
CHEMBL575259	570722	CHEMBL575259	570722		9	241.29	2.62	49.33	0	ONC(=O)CC(c1ccccc1)c2ccccc2	2922897	Inhibition					Not Active		0	BAO_0000376			592005	CHEMBL1050120	B	Inhibition of recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus at 20 uM after 10 mins by fluorimetric analysis	1	Scientific Literature				Intermediate	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			48688	CHEMBL1155182	19699639	Bioorg. Med. Chem. Lett.	2009	19	19	5684			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA, Zolinza	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	2922863	IC50	=	200	nM	6.7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	591998	CHEMBL1048395	B	Inhibition of recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus after 10 mins by fluorimetric analysis	1	Scientific Literature				Intermediate	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			48688	CHEMBL1155182	19699639	Bioorg. Med. Chem. Lett.	2009	19	19	5684			
CHEMBL396097	410986	CHEMBL396097	410986		6	227.26	2.37	49.33	0	ONC(=O)C(c1ccccc1)c2ccccc2	2922866	IC50	=	6600	nM	5.18			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	591998	CHEMBL1048395	B	Inhibition of recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus after 10 mins by fluorimetric analysis	1	Scientific Literature				Intermediate	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			48688	CHEMBL1155182	19699639	Bioorg. Med. Chem. Lett.	2009	19	19	5684			
CHEMBL1243261	702498	CHEMBL1243261	702498		2	303.31	1.79	104.46	0	ONC(=O)c1cc(CCCCC(=O)Nc2ccccc2)on1	3437987	IC50	=	18900	nM	4.72			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	658913	CHEMBL1246052	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			52747	CHEMBL1240475	20637529	Eur. J. Med. Chem.	2010	45	9	4331			
CHEMBL1767029	1142068	CHEMBL1767029	1142068		5	305.37	2.14	90.79	0	CNC(=O)\C(=N/O)\CCCCCCC(=O)Nc1ccccc1	6174065	IC50	=	100000	nM	4			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL1767030	1142069	CHEMBL1767030	1142069		14	355.43	3.05	90.79	0	CNC(=O)\C(=N/O)\CCCCCCC(=O)Nc1ccc2ccccc2c1	6174066	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL1767035	1142074	CHEMBL1767035	1142074		19	384.27	2.89	90.79	0	CNC(=O)\C(=N/O)\CCCCCCC(=O)Nc1cccc(Br)c1	6174071	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL2407723	1572129	CHEMBL2407723	1572129		24g	402.51	3.89	104.81	0	Nc1ccccc1NC(=O)c2ccc(CNC3=NC[C@@H](S3)c4ccccc4)cc2	13395002	IC50	=	81	nM	7.09			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL2407722	1572128	CHEMBL2407722	1572128		24f	402.51	3.89	104.81	0	Nc1ccccc1NC(=O)c2ccc(CNC3=NC[C@H](S3)c4ccccc4)cc2	13395003	IC50	=	111	nM	6.95			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL2407721	1572127	CHEMBL2407721	1572127		24e	416.54	4.21	104.81	0	Nc1ccccc1NC(=O)c2ccc(CNC3=N[C@H](Cc4ccccc4)CS3)cc2	13395004	IC50	=	82	nM	7.09			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL2407719	1572125	CHEMBL2407719	1572125		24c	418.51	3.65	125.04	0	Nc1ccccc1NC(=O)c2ccc(CNC3=N[C@H](CS3)c4ccc(O)cc4)cc2	13395006	IC50	=	44	nM	7.36			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL2407717	1572123	CHEMBL2407717	1572123		24a	402.51	3.89	104.81	0	Nc1ccccc1NC(=O)c2ccc(CNC3=N[C@H](CS3)c4ccccc4)cc2	13395008	IC50	=	85	nM	7.07			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL2407731	1572137	CHEMBL2407731	1572137		18b	552.62	4.62	141.9	1	CC(C)(C)OC(=O)N1C(Cc2c[nH]c3ccccc23)C(=O)N=C1NCc4ccc(cc4)C(=O)Nc5ccccc5N	13395017	IC50	=	48	nM	7.32			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL2431907	1583968	CHEMBL2431907	1583968		8b	262.3	1.48	69.64	0	CC(C)(C)C(=O)N1Cc2ccc(cc2C1)C(=O)NO	13467572	IC50	>	50000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	984990	CHEMBL2433164	B	Inhibition of full length C-terminal His6x-tagged recombinant human HDAC2 expressed in baculovirus using Arg-His-Lys-Lys (Ac) as substrate after 1 hr by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75006	CHEMBL2429834	23964961	J. Med. Chem.	2013	56	18	7201			
CHEMBL2018302	1336035	CHEMBL2018302	1336035	TUBASTATIN A	Tubastatin	335.4	3.08	57.5	0	CN1CCc2c(C1)c3ccccc3n2Cc4ccc(cc4)C(=O)NO	13467587	IC50	>	30000	nM				1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	984752	CHEMBL2432126	B	Inhibition of human recombinant HDAC2 using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75006	CHEMBL2429834	23964961	J. Med. Chem.	2013	56	18	7201			
CHEMBL2425951	1581070	CHEMBL2425951	1581070		7	413.47	4.14	82	0	CCC1=Nc2c(cccc2c3ccc(cc3)C(=O)NO)C(=O)N1CCc4ccccc4	13448890	Inhibition					Not Active		0	BAO_0000376			983469	CHEMBL2429404	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate at 1 uM	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL2420796	1579590	CHEMBL2420796	1579590		29, beta2-epi-azuE	514.61	1.8	153.69	1	CC(C)[C@H]1NC(=O)[C@H](C)[C@@H](C\C=C/CCC(=O)O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	13430402	Inhibition	<	50	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	979430	CHEMBL2423466	B	Inhibition of recombinant human HDAC2 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate at 50 uM after 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74596	CHEMBL2417416	23865683	J. Med. Chem.	2013	56	16	6512			
CHEMBL2420795	1579589	CHEMBL2420795	1579589		26, beta3-epi-azuE	514.61	1.8	153.69	1	CC(C)[C@H]1NC(=O)[C@@H](C)[C@H](C\C=C/CCC(=O)O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	13430403	Inhibition	<	50	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	979430	CHEMBL2423466	B	Inhibition of recombinant human HDAC2 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate at 50 uM after 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74596	CHEMBL2417416	23865683	J. Med. Chem.	2013	56	16	6512			
CHEMBL2018302	1336035	CHEMBL2018302	1336035	TUBASTATIN A	tubastatin A	335.4	3.08	57.5	0	CN1CCc2c(C1)c3ccccc3n2Cc4ccc(cc4)C(=O)NO	13431402	IC50	>	30000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	977771	CHEMBL2420992	B	Inhibition of human recombinant HDAC2 protein using RHKKAc from p53 as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74749	CHEMBL2417402	23627282	J. Med. Chem.	2013	56	16	6297			
CHEMBL2364628	1540500	CHEMBL2364628	1540500	RICOLINOSTAT	ACY-1215	433.5	3.92	107.45	0	ONC(=O)CCCCCCNC(=O)c1cnc(nc1)N(c2ccccc2)c3ccccc3	13431412	IC50	=	48	nM	7.32			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	977760	CHEMBL2424307	B	Inhibition of HDAC2 (unknown origin) using fluorophore tripeptide as substrate after 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74749	CHEMBL2417402	23627282	J. Med. Chem.	2013	56	16	6297			
CHEMBL2442694	1589221	CHEMBL2442694	1589221		32	709.78	5.69	159.83	3	COc1cc(cc(OC)c1O)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](Nc4ccc(OCCCCCCC(=O)Nc5ccccc5N)cc4)c6cc7OCOc7cc26	13502670	IC50	=	10390	nM	4.98			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	989630	CHEMBL2445174	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	75370	CHEMBL2439983	24095018	Bioorg. Med. Chem.	2013	21	22	6981			
CHEMBL257973	425560	CHEMBL257973	425560	AZUMAMIDE D	8, azuD	485.58	.33	159.48	0	C[C@H]1NC(=O)[C@@H](C)NC(=O)[C@@H](C)[C@@H](C\C=C/CCC(=O)N)NC(=O)[C@@H](Cc2ccccc2)NC1=O	13431792	Ki	>	5000	nM				0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	979441	CHEMBL2423477	B	Inhibition of recombinant human HDAC2 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74596	CHEMBL2417416	23865683	J. Med. Chem.	2013	56	16	6512			
CHEMBL257972	425559	CHEMBL257972	425559	AZUMAMIDE C	7, azuC	530.61	1.56	173.92	2	CC(C)[C@H]1NC(=O)[C@@H](C)[C@@H](C\C=C/CCC(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)NC1=O	13431793	Ki	=	40	nM	7.4			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	979441	CHEMBL2423477	B	Inhibition of recombinant human HDAC2 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74596	CHEMBL2417416	23865683	J. Med. Chem.	2013	56	16	6512			
CHEMBL2390999	1564566	CHEMBL2390999	1564566		12b	393.44	2.55	90.9	0	ONC(=O)\C=C\c1ccc2OC3(CCN(Cc4ccccc4)CC3)NC(=O)c2c1	13337922	IC50	=	192	nM	6.72			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	964225	CHEMBL2395195	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	73929	CHEMBL2390828	23644210	Eur. J. Med. Chem.	2013	64		273			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	13393205	Ki	=	1.06	nM	8.97			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	972539	CHEMBL2410191	B	Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74297	CHEMBL2407068		ACS Med. Chem. Lett.	2013	4	8	757			
CHEMBL2408237	1572648	CHEMBL2408237	1572648		4a	198.22	2.22	37.29	0	OC1=CC=CC=C(C1=O)c2ccccc2	13393216	Ki	=	.26	nM	9.59			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	972539	CHEMBL2410191	B	Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74297	CHEMBL2407068		ACS Med. Chem. Lett.	2013	4	8	757			
CHEMBL2408246	1572657	CHEMBL2408246	1572657		7e	178.23	2.35	37.29	0	CCC(C)C1=CC(=O)C(=CC=C1)O	13393219	Ki	=	.22	nM	9.66			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	972539	CHEMBL2410191	B	Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74297	CHEMBL2407068		ACS Med. Chem. Lett.	2013	4	8	757			
CHEMBL2408245	1572656	CHEMBL2408245	1572656		7d	178.23	2.1	37.29	0	CC(C)(C)C1=CC(=O)C(=CC=C1)O	13393220	Ki	=	.13	nM	9.89			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	972539	CHEMBL2410191	B	Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74297	CHEMBL2407068		ACS Med. Chem. Lett.	2013	4	8	757			
CHEMBL2408242	1572653	CHEMBL2408242	1572653		7a	198.22	2.22	37.29	0	OC1=CC=CC(=CC1=O)c2ccccc2	13393222	Ki	=	.06	nM	10.22			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	972539	CHEMBL2410191	B	Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74297	CHEMBL2407068		ACS Med. Chem. Lett.	2013	4	8	757			
CHEMBL2408247	1572658	CHEMBL2408247	1572658		7f	190.24	2.44	37.29	0	OC1=CC=CC(=CC1=O)C2CCCC2	13393223	Ki	=	.04	nM	10.4			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	972539	CHEMBL2410191	B	Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74297	CHEMBL2407068		ACS Med. Chem. Lett.	2013	4	8	757			
CHEMBL2398525	1569047	CHEMBL2398525	1569047		39	463.61	4.68	129.87	0	Oc1c(NCc2cccs2)cc(CC(=O)NCc3ccccc3)cc1NCc4cccs4	13348841	Activity	>	75	%				0	BAO_0001103	UO_0000187	http://qudt.org/vocab/unit#Percent	967676	CHEMBL2399518	B	Inhibition of recombinant human HDAC2 using Arg-His-Lys-Lys(Ac) as substrate assessed as residual activity at 3.3 x 10'-5 M after 2 hrs by fluorescence assay relative to control	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74058	CHEMBL2396570	23693069	Bioorg. Med. Chem.	2013	21	13	3795			
CHEMBL2398524	1569046	CHEMBL2398524	1569046		38	415.53	1.55	146.85	0	Oc1c(NCc2nccs2)cc(cc1NCc3nccs3)C(=O)N4CCCC4	13348842	Activity	>	75	%				0	BAO_0001103	UO_0000187	http://qudt.org/vocab/unit#Percent	967676	CHEMBL2399518	B	Inhibition of recombinant human HDAC2 using Arg-His-Lys-Lys(Ac) as substrate assessed as residual activity at 3.3 x 10'-5 M after 2 hrs by fluorescence assay relative to control	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74058	CHEMBL2396570	23693069	Bioorg. Med. Chem.	2013	21	13	3795			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	13361785	IC50	=	14	nM	7.85			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	967402	CHEMBL2401043	B	Inhibition of HDAC2 (unknown origin) after 30 mins by fluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74085	CHEMBL2396564	23719282	Bioorg. Med. Chem.	2013	21	14	4201			
CHEMBL2396902	1567408	CHEMBL2396902	1567408		Jdelta, JAHA-PIP-delta	1479.61				CN(C)CCCNC(=O)c1cc(NC(=O)c2cc(NC(=O)c3cc(NC(=O)c4nc(NC(=O)CCCNC(=O)c5cc(NC(=O)c6cc(NC(=O)c7cc(NC(=O)c8nc(NC(=O)CCNC(=O)CCNC(=O)CCCCCCC(=O)NO)cn8C)cn7C)cn6C)cn5C)cn4C)cn3C)cn2C)cn1C	13361787	IC50	=	1120	nM	5.95			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	967402	CHEMBL2401043	B	Inhibition of HDAC2 (unknown origin) after 30 mins by fluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74085	CHEMBL2396564	23719282	Bioorg. Med. Chem.	2013	21	14	4201			
CHEMBL514138	453588	CHEMBL267178	1549	CGS-27023A	CGS, CGS 27023A	393.46	1.56	117.21	0	Cl.COc1ccc(cc1)S(=O)(=O)N(Cc2cccnc2)[C@H](C(C)C)C(=O)NO	13488732	Inhibition					Not Active		0	BAO_0000376			987733	CHEMBL2439711	B	Inhibition of HDAC2 (unknown origin)-mediated deacetylation at 10 uM preincubated for 5 mins prior to substrate addition measured after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75182	CHEMBL2434956	24074025	J. Med. Chem.	2013	56	20	7997			
CHEMBL217285	361297	CHEMBL217285	361297		6, RCD-1	277.25	-.06	90.79	0	CC1=NC(=C(O)C(=O)N1)C(=O)NCc2ccc(F)cc2	13488736	Inhibition					Not Active		0	BAO_0000376			987733	CHEMBL2439711	B	Inhibition of HDAC2 (unknown origin)-mediated deacetylation at 10 uM preincubated for 5 mins prior to substrate addition measured after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75182	CHEMBL2434956	24074025	J. Med. Chem.	2013	56	20	7997			
CHEMBL93	9217	CHEMBL93	9217	ZILEUTON	Zileuton, Zyflo	236.29	2.18	94.8	0	CC(N(O)C(=O)N)c1cc2ccccc2s1	13488737	Inhibition					Not Active		0	BAO_0000376			987733	CHEMBL2439711	B	Inhibition of HDAC2 (unknown origin)-mediated deacetylation at 10 uM preincubated for 5 mins prior to substrate addition measured after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75182	CHEMBL2434956	24074025	J. Med. Chem.	2013	56	20	7997			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	2, SAHA, Vorinostat	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	13488738	Inhibition					Active		0	BAO_0000376			987733	CHEMBL2439711	B	Inhibition of HDAC2 (unknown origin)-mediated deacetylation at 10 uM preincubated for 5 mins prior to substrate addition measured after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75182	CHEMBL2434956	24074025	J. Med. Chem.	2013	56	20	7997			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	2, SAHA, Vorinostat	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	13488776	IC50	=	10	nM	8			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	987745	CHEMBL2439836	B	Inhibition of HDAC2 (unknown origin)-mediated deacetylation preincubated for 5 mins prior to substrate addition measured after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	75182	CHEMBL2434956	24074025	J. Med. Chem.	2013	56	20	7997			
CHEMBL2170017	1429496	CHEMBL2170017	1429496		11	678.86	2.7	193.57	2	CCC(=O)CCCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)CCN(CC=C(C)C)C(=O)CN(CCc2c[nH]c3ccccc23)C1=O	12103870	IC50	=	1200	nM	5.92			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	861541	CHEMBL2174389	B	Inhibition of human recombinant HDAC2 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	65900	CHEMBL2169795		ACS Med. Chem. Lett.	2012	3	9	749			
CHEMBL2178343	1439137	CHEMBL2178343	1439137		C142	314.36	2.54	108.28	0	ONC(=O)c1cccc(c1)c2cn(CCc3ccsc3)nn2	12148685	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	878901	CHEMBL2185052	B	Inhibition of HDAC2 by fluorometric assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			66685	CHEMBL2176939	23116147	J. Med. Chem.	2012	55	22	9562			
CHEMBL2333339	1522977	CHEMBL2333339	1522977		3	285.3	.81	91.32	0	ONC(=O)c1ccc(cc1)C(=O)NCCc2ccncc2	12680999	IC50	=	341	nM	6.47			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	944722	CHEMBL2340968	B	Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772			
CHEMBL2407726	1572132	CHEMBL2407726	1572132		8f					CC(C)(C)[Si](C)(C)OCc1ccc(NC(=O)c2ccc(CNc3nccc(n3)c4cccnc4)cc2)c(N)c1	13395022	IC50	>	20000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL2408239	1572650	CHEMBL2408239	1572650		4c	228.24	2.2	46.53	0	COc1ccc(cc1)C2=CC=CC=C(O)C2=O	13393208	Ki	=	.81	nM	9.09			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	972539	CHEMBL2410191	B	Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74297	CHEMBL2407068		ACS Med. Chem. Lett.	2013	4	8	757			
CHEMBL3109980	1615185	CHEMBL3109980	1615185		54	345.78	2.96	67.79	0	ONC(=O)[C@@H]1[C@@H]([C@H]1c2cc(Cl)c3OCCOc3c2)c4ccccc4	13896922	IC50	=	31000	nM	4.51			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1287880	CHEMBL3112164	B	Inhibition of human recombinant full length HDAC2 using (Ac)Arg-Gly-Lys(Ac) as substrate after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76664	CHEMBL3108758	24261862	J. Med. Chem.	2013	56	24	9934			
CHEMBL3098603	1609373	CHEMBL3098603	1609373		33	278.35	2.49	78.43	0	Cc1cccc(NC(=O)CCCCCCC(=O)NO)c1	13867801	IC50	=	239	nM	6.62			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL3421741	1841177	CHEMBL3421741	1841177		10e	433.89	3.24	106.07	0	Nc1ccccc1NC(=O)c2ccc(CNCc3onc(n3)c4ccc(Cl)cc4)cc2	15234970	IC50	=	430	nM	6.37			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL3335298	1791431	CHEMBL3335298	1791431		20	388.46	4.56	72.08	0	ONC(=O)CCCCc1ccn(Cc2ccc(cc2)n3ccc4ccccc34)n1	15086177	IC50	=	558	nM	6.25			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1433878	CHEMBL3388839	B	Inhibition of human recombinant HDAC2 after 60 mins by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89339	CHEMBL3352093	25218912	Eur. J. Med. Chem.	2014	86		639			
CHEMBL3427774	1845170	CHEMBL3427774	1845170		13e	325.43	4.19	100.01	0	CC1(C)CC(C(=O)N)c2[nH]nc(c2C1)c3cc4ccccc4s3	15256001	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL1957464	1282995	CHEMBL1957464	1282995		8a	436.53	2.36	124.93	0	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)N3CCOCC3)cc2)c4cccs4	8048587	IC50	=	880	nM	6.06			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	807676	CHEMBL1959441	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			61262	CHEMBL1955769	22321215	Bioorg. Med. Chem. Lett.	2012	22	5	1926			
CHEMBL2022831	1338204	CHEMBL2022831	1338204		10	569.69	7.1	173.94	2	[O-][N+](=O)c1cccc(COC(=O)[C@H](CCCCCCSSc2ccccn2)NC(=O)OCc3ccccc3)c1	10862545	IC50	=	48.5	nM	7.31			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	816365	CHEMBL2024763	B	Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	61731	CHEMBL2021837	22465091	Eur. J. Med. Chem.	2012	52		111			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	10862515	IC50	=	1.1	nM	8.96			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	816365	CHEMBL2024763	B	Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	61731	CHEMBL2021837	22465091	Eur. J. Med. Chem.	2012	52		111			
CHEMBL2170173	1429654	CHEMBL2170173	1429654		1h	495.53	5.85	173.36	1	COc1cc(COc2ccc(NC(=O)CCCCCCC(=O)OCCN=[N+]=[N-])cc2)cc(c1)N=[N+]=[N-]	12114359	IC50	=	72000	nM	4.14			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	864740	CHEMBL2175007	B	Inhibition of human recombinant HDAC2 using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by microplate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	66025	CHEMBL2169804	23010266	Bioorg. Med. Chem. Lett.	2012	22	21	6621			
CHEMBL2177582	1438368	CHEMBL2177582	1438368		60	492.97	3.98	87.46	0	CN1C[C@@H]([C@H](C1)c2ccc(\C=C\C(=O)Nc3ccccc3N)cc2F)C(=O)Nc4ccc(Cl)cc4	12136057	IC50	=	220	nM	6.66			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	874014	CHEMBL2186139	B	Inhibition of HDAC2 using p53 (379 to 382 residues) based fluorogenic peptide substrate	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			66641	CHEMBL2177000	23061376	J. Med. Chem.	2012	55	20	8903			
CHEMBL235192	399327	CHEMBL235192	399327		13	443.49	3.85	98.75	0	COc1ccc(NCc2ccc(cc2)C(=O)Nc3cc(ccc3N)c4cocc4)cc1OC	1998351	Inhibition	<	50	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	451049	CHEMBL900130	B	Inhibition of human recombinant HDAC2 at 20 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL389687	382029	CHEMBL389687	382029		1	502.6	3.72	133.55	1	N[C@@H](Cc1ccccc1)C(=O)Nc2ccccc2c3ccc(NC(=O)CCCCCCC(=O)NO)cc3	1902504	IC50	=	156	nM	6.81			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	439074	CHEMBL889422	B	Inhibition of His-tagged HDAC2 expressed in Sf9 cells by fluorescence-based assay	1	Scientific Literature				Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			36060	CHEMBL1145385	17539623	J. Med. Chem.	2007	50	13	3054	1759	CHEMBL3308860	Sf9
CHEMBL235192	399327	CHEMBL235192	399327		13	443.49	3.85	98.75	0	COc1ccc(NCc2ccc(cc2)C(=O)Nc3cc(ccc3N)c4cocc4)cc1OC	1998269	IC50	=	70	nM	7.15			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL561483	555752	CHEMBL561483	555752		4h	435.52	5	99.37	0	COc1cccc2c(c[nH]c12)C(CCCCCC(=O)NO)c3c[nH]c4c(OC)cccc34	2720673	IC50	=	440	nM	6.36			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	585885	CHEMBL1053556	B	Inhibition of human HDAC2 by fluorimetry	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	48183	CHEMBL1153591	19359173	Bioorg. Med. Chem. Lett.	2009	19	10	2840			
CHEMBL551151	564769	CHEMBL551151	564769		4	257.28	2.61	69.56	0	ONC(=O)CCc1ccc(cc1)c2ccc(O)cc2	2657784	IC50	=	1700	nM	5.77			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL1094709	614708	CHEMBL1094709	614708		11a	407.47	3.71	109.14	0	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)n2cc(nn2)c3ccccc3	3201402	IC50	=	25.1	nM	7.6			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	616013	CHEMBL1101057	B	Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			50398	CHEMBL1154884	20055418	J. Med. Chem.	2010	53	3	1347			
CHEMBL1096981	627084	CHEMBL1096981	627084		2	629.75	2.88	160.69	1	C[C@H](O)C(=O)CCCCC[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC1=O	3290052	IC50	=	179	nM	6.75			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	629198	CHEMBL1121312	B	Inhibition of full length HDAC2 expressed in HEK293 cells after 15 mins by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51141	CHEMBL1158553	20381359	Bioorg. Med. Chem.	2010	18	9	3252	722	CHEMBL3307715	HEK293
CHEMBL2022834	1338207	CHEMBL2022834	1338207		13	624.81	9.02	128.12	2	O=C(N[C@@H](CCCCCCSSc1ccccn1)C(=O)OCc2c3ccccc3cc4ccccc24)OCc5ccccc5	10862554	IC50	=	43.6	nM	7.36			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	816365	CHEMBL2024763	B	Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	61731	CHEMBL2021837	22465091	Eur. J. Med. Chem.	2012	52		111			
CHEMBL2012813	1333876	CHEMBL2012813	1333876		2	581.75	3.44	140.47	1	CCC(=O)CCCCC[C@@H]1NC(=O)[C@H](C)N(C)C(=O)C[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	12103874	IC50	=	70	nM	7.15			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	861541	CHEMBL2174389	B	Inhibition of human recombinant HDAC2 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	65900	CHEMBL2169795		ACS Med. Chem. Lett.	2012	3	9	749			
CHEMBL2407724	1572130	CHEMBL2407724	1572130		24h	478.61	5.5	104.81	1	Nc1ccccc1NC(=O)c2ccc(CNC3=N[C@@H]([C@H](S3)c4ccccc4)c5ccccc5)cc2	13395001	IC50	=	425	nM	6.37			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL2398523	1569045	CHEMBL2398523	1569045		37	467.52	4.44	99.67	0	Oc1c(NCc2occc2)cc(cc1NCc3occc3)C(=O)NCc4ccc5ccccc5c4	13348846	Activity	=	69.38	%				0	BAO_0001103	UO_0000187	http://qudt.org/vocab/unit#Percent	967676	CHEMBL2399518	B	Inhibition of recombinant human HDAC2 using Arg-His-Lys-Lys(Ac) as substrate assessed as residual activity at 3.3 x 10'-5 M after 2 hrs by fluorescence assay relative to control	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74058	CHEMBL2396570	23693069	Bioorg. Med. Chem.	2013	21	13	3795			
CHEMBL3098689	1609460	CHEMBL3098689	1609460		9	404.46	.86	136.63	0	ONC(=O)CCCCC[C@H](NC(=O)[C@@H]1CCCC(=O)N1)C(=O)Nc2ccccc2	13867812	IC50	=	89	nM	7.05			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL3235787	1734314	CHEMBL3235787	1734314		2d	429.55	5.69	58.56	1	COc1ccc(cc1C23CC4CC(CC(C4)C2)C3)c5ccc(\C=C\C=C\C(=O)NO)cc5	14570883	IC50	>	10000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1335247	CHEMBL3238600	B	Inhibition of HDAC2 in human HeLa cells using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			82343	CHEMBL3232764	24742384	Eur. J. Med. Chem.	2014	79		251			
CHEMBL3356926	1821069	CHEMBL3356926	1821069		46, ST7542	439.57	2.92	126.1	0	SCCCCC[C@H](NC(=O)[C@@H]1[C@H](CNC1=O)c2ccccc2)C(=O)Nc3ccccc3	15138228	IC50	=	2230	nM	5.65			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3427757	1845153	CHEMBL3427757	1845153		3m	247.32	2.54	100.01	0	NC(=O)C1CCCc2c1[nH]nc2c3cccs3	15255907	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL515295	519581	CHEMBL515295	519581		13e	366.44	.63	131.79	0	COc1cc(NC(=O)CCCCCNS(=O)(=O)N)c2ncccc2c1	2600491	Activity					Not Active		0	BAO_0000375			540708	CHEMBL1027321	B	Inhibition of human recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus by fluorimetry	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			46637	CHEMBL1149076	19084395	Bioorg. Med. Chem. Lett.	2009	19	2	336			
CHEMBL1631914	1054906	CHEMBL1631914	1054906		(S)-9	454.52	3.4	106.11	0	COc1cc2COc3ccccc3NC(=O)[C@H](CCCCCC(=O)NO)OC\C=C/c(c2)c1	5090672	IC50	=	158	nM	6.8			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	690171	CHEMBL1634301	B	Inhibition of human HDAC2 by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	54338	CHEMBL1629537	21073160	J. Med. Chem.	2010	53	23	8387			
CHEMBL2178344	1439138	CHEMBL2178344	1439138		C32	308.33	2.88	80.04	0	ONC(=O)c1cccc(c1)c2cn(CCc3ccccc3)nn2	12148686	IC50	=	76000	nM	4.12			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	878901	CHEMBL2185052	B	Inhibition of HDAC2 by fluorometric assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			66685	CHEMBL2176939	23116147	J. Med. Chem.	2012	55	22	9562			
CHEMBL2408244	1572655	CHEMBL2408244	1572655		7c	258.27	2.19	55.76	0	COc1ccc(OC)c(c1)C2=CC(=O)C(=CC=C2)O	13393214	Ki	=	.51	nM	9.29			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	972539	CHEMBL2410191	B	Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74297	CHEMBL2407068		ACS Med. Chem. Lett.	2013	4	8	757			
CHEMBL2022829	1338202	CHEMBL2022829	1338202		8	612.8	8.57	128.12	2	O=C(N[C@@H](CCCCCCSSc1ccccn1)C(=O)OCC2c3ccccc3c4ccccc24)OCc5ccccc5	10862539	IC50	=	5.2	nM	8.28			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	816365	CHEMBL2024763	B	Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	61731	CHEMBL2021837	22465091	Eur. J. Med. Chem.	2012	52		111			
CHEMBL519491	508154	CHEMBL519491	508154		6c	407.47	3.71	109.14	0	ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)c2cn(nn2)c3ccccc3	2351867	IC50	=	47.5	nM	7.32			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL1800248	1161311	CHEMBL1800248	1161311		14	289.35	2.4	100.41	0	CC(=O)Nc1ccc(CSc2nc(C)cc(O)n2)cc1	6283037	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL460963	458060	CHEMBL460963	458060		2b	420.55	4.5	70.39	0	CN(C)CC(C)(C)Cn1c(CCc2ccccc2)nc3cc(\C=C\C(=O)NO)ccc13	6370652	Ki	=	39	nM	7.41			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	769058	CHEMBL1832521	B	Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58940	CHEMBL1828590	21634430	J. Med. Chem.	2011	54	13	4694			
CHEMBL1958440	1283981	CHEMBL1958440	1283981		20	204.18	1.24	75.36	0	ONC(=O)\C=C\c1oc2ccccc2n1	8054619	ED50	=	554	nM			Non standard unit for type	0	BAO_0003036	UO_0000065	http://www.openphacts.org/units/Nanomolar	808465	CHEMBL1961041	B	Inhibition of human recombinant HDAC2 expressed using baculovirus expression system using Flour- De-Lys as substrate after 3 hrs by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			61278	CHEMBL1955831	22326398	Bioorg. Med. Chem. Lett.	2012	22	5	1886			
CHEMBL2431912	1583973	CHEMBL2431912	1583973		10a	313.35	1.96	74.56	0	Cn1cccc1C(=O)N2CCCc3cc(ccc3C2)C(=O)NO	13467571	IC50	>	50000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	984990	CHEMBL2433164	B	Inhibition of full length C-terminal His6x-tagged recombinant human HDAC2 expressed in baculovirus using Arg-His-Lys-Lys (Ac) as substrate after 1 hr by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75006	CHEMBL2429834	23964961	J. Med. Chem.	2013	56	18	7201			
CHEMBL491130	461171	CHEMBL491130	461171		(S)-18					OB(O)CCCCC[C@H](NC(=O)c1ccccc1)C(=O)Nc2cccc(c2)c3ccccc3	2513625	IC50	=	3600	nM	5.44			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	498746	CHEMBL1021938	B	Inhibition of human recombinant HDAC2 by fluorimetry	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47121	CHEMBL1138526	19419205	J. Med. Chem.	2009	52	9	2909			
CHEMBL511432	479374	CHEMBL511432	479374		7	401.44	1.98	171.61	0	Nc1cccc(c1)c2csc(NC(=O)CCCCc3onc(c3)C(=O)NO)n2	2641980	IC50	=	164	nM	6.79			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	500548	CHEMBL971413	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46730	CHEMBL1136917	19419863	Bioorg. Med. Chem. Lett.	2009	19	11	3023			
CHEMBL2057822	1353577	CHEMBL2057822	1353577		2c	553.6	6.08	221.19	2	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2)c4cccs4	10955020	Inhibition					tde		0	BAO_0000376			829163	CHEMBL2059985	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057822	1353577	CHEMBL2057822	1353577		2c	553.6	6.08	221.19	2	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2)c4cccs4	10955027	Activity					Active		0	BAO_0000375			829164	CHEMBL2059986	B	Binding affinity to His-tagged human HDAC2 assessed as decrease in biotinylation of HDAC2 at 25 uM preincubated for 24 hrs measured after 1 hr by Western blot analysis in presence of five-fold molar excess of Trichostatin A	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057822	1353577	CHEMBL2057822	1353577		2c	553.6	6.08	221.19	2	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2)c4cccs4	10955045	Inhibition					Active		0	BAO_0000376			829166	CHEMBL2059988	B	Inhibition of HDAC2 in human MDA-MB-231 cells assessed as inhibition of H4 deacetylation at 50 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025	325	CHEMBL3307960	MDA-MB-231
CHEMBL2057822	1353577	CHEMBL2057822	1353577		2c	553.6	6.08	221.19	2	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2)c4cccs4	10954408	Ratio IC50	=	7.1					0	BAO_0000179			829156	CHEMBL2059978	B	Ratio of IC50 for human HDAC2 preincubated for 3 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057822	1353577	CHEMBL2057822	1353577		2c	553.6	6.08	221.19	2	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2)c4cccs4	10954421	Ratio IC50	=	24					0	BAO_0000179			829157	CHEMBL2059979	B	Ratio of IC50 for human HDAC2 preincubated for 24 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057822	1353577	CHEMBL2057822	1353577		2c	553.6	6.08	221.19	2	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2)c4cccs4	10954278	IC50	=	7100	nM	5.15			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829146	CHEMBL2059968	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 5 mins measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057822	1353577	CHEMBL2057822	1353577		2c	553.6	6.08	221.19	2	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2)c4cccs4	10954291	IC50	=	1000	nM	6			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829147	CHEMBL2059969	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 3 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057822	1353577	CHEMBL2057822	1353577		2c	553.6	6.08	221.19	2	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2)c4cccs4	10954304	IC50	=	300	nM	6.52			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829148	CHEMBL2059970	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 24 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2047617	1351041	CHEMBL2047617	1351041		8a	410.42	5.15	92.74	1	[O-][N+](=O)c1ccc(cc1)c2nn(cc2\C=C/C(=O)Nc3ccccc3)c4ccccc4	10947984	IC50	=	1150	nM	5.94			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	827843	CHEMBL2051252	B	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62524	CHEMBL2046430	22705022	Bioorg. Med. Chem.	2012	20	14	4430			
CHEMBL1771487	1143798	CHEMBL1771487	1143798		A7B4	568.62	3.91	137.39	1	ONC(=O)c1cccc(c1)C(=O)N\N=C\c2cccc(CN3C[C@@H](OC(=O)CC\C=C\CCC3=O)c4ccccc4)c2	6182570	IC50	=	5000	nM	5.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	744275	CHEMBL1772082	B	Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			57403	CHEMBL1770095	21334896	Bioorg. Med. Chem. Lett.	2011	21	9	2601			
CHEMBL2323286	1517443	CHEMBL2323286	1517443		7	479.58	.99	208.02	0	CC(C)[C@@H]1NC(=O)Cn2nnc(n2)c3csc(CNC(=O)C[C@H](OC1=O)\C=C\CCS)n3	12659627	IC50	=	224	nM	6.65			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	938235	CHEMBL2328538	B	Inhibition of C-terminal His-tagged full length human recombinant HDAC2 expressed in baculovirus expression system using fluorogenic acetylated peptide as substrate preincubated with enzyme for 10 mins prior to substrate addition measured after 60 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72033	CHEMBL2321647		ACS Med. Chem. Lett.	2013	4	1	132			
CHEMBL2333342	1522980	CHEMBL2333342	1522980		6	256.26	1.63	78.43	0	ONC(=O)c1ccc(cc1)C(=O)Nc2ccccc2	12680996	IC50	=	321	nM	6.49			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	944722	CHEMBL2340968	B	Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772			
CHEMBL2381517	1560927	CHEMBL2381517	1560927		3, BRD73594	284.31	1.96	78.43	0	ONC(=O)c1cccc(c1)C(=O)NCCc2ccccc2	13297518	Inhibition					Active		0	BAO_0000376			958690	CHEMBL2383992	B	Inhibition of HDAC2 in human HeLa cells assessed as increase in histone H3 acetylation at 10 uM after 48 hrs by Western blotting analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			73668	CHEMBL2380312	23672185	J. Med. Chem.	2013	56	11	4816	308	CHEMBL3308376	HeLa
CHEMBL2381517	1560927	CHEMBL2381517	1560927		3, BRD73594	284.31	1.96	78.43	0	ONC(=O)c1cccc(c1)C(=O)NCCc2ccccc2	13297588	IC50	=	9000	nM	5.05			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	958899	CHEMBL2384807	B	Inhibition of HDAC2 (unknown origin) after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	73668	CHEMBL2380312	23672185	J. Med. Chem.	2013	56	11	4816			
CHEMBL2431906	1583967	CHEMBL2431906	1583967		8a	285.3	1.19	74.56	0	Cn1cccc1C(=O)N2Cc3ccc(cc3C2)C(=O)NO	13467573	IC50	>	50000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	984990	CHEMBL2433164	B	Inhibition of full length C-terminal His6x-tagged recombinant human HDAC2 expressed in baculovirus using Arg-His-Lys-Lys (Ac) as substrate after 1 hr by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75006	CHEMBL2429834	23964961	J. Med. Chem.	2013	56	18	7201			
CHEMBL2408240	1572651	CHEMBL2408240	1572651		4d	258.27	2.19	55.76	0	COc1ccc(OC)c(c1)C2=CC=CC=C(O)C2=O	13393215	Ki	=	.42	nM	9.38			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	972539	CHEMBL2410191	B	Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74297	CHEMBL2407068		ACS Med. Chem. Lett.	2013	4	8	757			
CHEMBL483477	500141	CHEMBL483477	500141		35	292.37	2.33	78.43	0	ONC(=O)CCCCCCC(=O)NCCc1ccccc1	13867797	IC50	=	5160	nM	5.29			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL3098695	1609466	CHEMBL3098695	1609466		27	376.41	.08	136.63	0	ONC(=O)CCCCC[C@H](NC(=O)[C@@H]1CC(=O)N1)C(=O)Nc2ccccc2	13867806	IC50	=	89	nM	7.05			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL3352994	1817097	CHEMBL3352994	1817097		7b	518.6	1.55	173.92	2	CC(C)[C@H]1NC(=O)C[C@@H](CCCCCC(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)NC1=O	15126326	Ki	=	300	nM	6.52			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	1440125	CHEMBL3382538	B	Inhibition of human recombinant HDAC2 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89689	CHEMBL3351463	25380299	J. Med. Chem.	2014	57	22	9644			
CHEMBL3098695	1609466	CHEMBL3098695	1609466		9	376.41	.08	136.63	0	ONC(=O)CCCCC[C@H](NC(=O)[C@@H]1CC(=O)N1)C(=O)Nc2ccccc2	14976178	IC50	=	143	nM	6.84			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1444620	CHEMBL3376039	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90082	CHEMBL3352629	25563890	Bioorg. Med. Chem. Lett.	2015	25	3	459			
CHEMBL481805	474143	CHEMBL481805	474143		25	385.42	2.68	121.61	0	Nc1ccccc1NC(=O)c2ccc(CNc3nccc(n3)c4ccn[nH]4)cc2	2489839	IC50	=	140	nM	6.85			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	515333	CHEMBL1036510	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			45586	CHEMBL1143305	19114304	Bioorg. Med. Chem. Lett.	2009	19	3	644			
CHEMBL96051	158844	CHEMBL96051	158844	SCRIPTAID	14	326.35	2.12	86.71	0	ONC(=O)CCCCCN1C(=O)c2cccc3cccc(C1=O)c23	3390009	Ki	=	2.2	nM	8.66			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL1767033	1142072	CHEMBL1767033	1142072		17	348.44	2.3	94.02	0	CNC(=O)\C(=N/O)\CCCCCCC(=O)Nc1ccc(cc1)N(C)C	6174069	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL1722433	1103164	CHEMBL1722433	1103164		32	303.38	2.66	100.41	0	Cc1cc(O)nc(SCC(=O)NCCc2ccccc2)n1	6283055	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL407420	439967	CHEMBL407420	439967		1b	419.47	2.75	97.05	0	Nc1ccccc1NC(=O)c2ccc(CN(CCO)Cc3ccc4OCOc4c3)cc2	8048585	IC50	=	3360	nM	5.47			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	807676	CHEMBL1959441	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			61262	CHEMBL1955769	22321215	Bioorg. Med. Chem. Lett.	2012	22	5	1926			
CHEMBL399389	399328	CHEMBL399389	399328		14	509.62	5.9	113.85	2	COc1ccc(NCc2ccc(cc2)C(=O)Nc3cc(ccc3N)c4cc5ccccc5s4)cc1OC	1998350	Inhibition	<	50	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	451049	CHEMBL900130	B	Inhibition of human recombinant HDAC2 at 20 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL235674	399306	CHEMBL235674	399306		2b	458.53	3.54	134.57	0	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2)c4cccs4	2073945	IC50	=	6	nM	8.22			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	461756	CHEMBL927762	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38240	CHEMBL1140803	18060775	Bioorg. Med. Chem. Lett.	2008	18	2	726			
CHEMBL227119	382031	CHEMBL227119	382031		4	280.32	.23	93.7	0	CN(C)c1ccc(CNC(=O)NCCC(=O)NO)cc1	1902514	IC50	=	492	nM	6.31			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	439074	CHEMBL889422	B	Inhibition of His-tagged HDAC2 expressed in Sf9 cells by fluorescence-based assay	1	Scientific Literature				Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			36060	CHEMBL1145385	17539623	J. Med. Chem.	2007	50	13	3054	1759	CHEMBL3308860	Sf9
CHEMBL140525	232394	CHEMBL140525	232394		TWZ 112	485.53	3.02	124.51	0	ON(CCCCCC(C(=O)Nc1cnc2ccccc2c1)C(=O)Nc3cnc4ccccc4c3)C=O	1271620	IC50	=	200	nM	6.7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	87875	CHEMBL697297	B	Inhibition of Histone deacetylase 2 (HDAC2) activity of HeLa nuclear extracts	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	6553	CHEMBL1137945	14698179	Bioorg. Med. Chem. Lett.	2004	14	2	449			
CHEMBL216641	363404	CHEMBL216641	363404		6	623.74	5.5	148.33	3	COc1ccc2[nH]c(C)c(CC(=O)N[C@@H](CCCCCC(=O)NO)C(=O)NCCc3c([nH]c4ccccc34)c5ccccc5)c2c1	1792261	IC50	=	4	nM	8.4			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	422130	CHEMBL907066	B	Inhibition of HDAC2 (mean IC50)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	34712	CHEMBL1137275	16987657	Bioorg. Med. Chem. Lett.	2006	16	23	5948			
CHEMBL235413	399333	CHEMBL235413	399333		17	460.54	5.2	108.06	1	COc1ccc(NCc2ccc(cc2)C(=O)Nc3cc(ccc3O)c4cccs4)cc1OC	1998347	Inhibition	<	50	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	451049	CHEMBL900130	B	Inhibition of human recombinant HDAC2 at 20 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL399389	399328	CHEMBL399389	399328		14	509.62	5.9	113.85	2	COc1ccc(NCc2ccc(cc2)C(=O)Nc3cc(ccc3N)c4cc5ccccc5s4)cc1OC	1998268	IC50	>	10000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	2351832	IC50	=	164	nM	6.79			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL407959	429751	CHEMBL407959	429751		11	486.61	4.62	99.87	0	COc1ccc2[nH]c(C)c(CC(=O)N[C@@H](CCCCCC(=O)C)c3ncc([nH]3)c4ccccc4)c2c1	2259882	IC50	=	110	nM	6.96			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	496826	CHEMBL1008839	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			45815	CHEMBL1152225	18809328	Bioorg. Med. Chem. Lett.	2008	18	20	5528			
CHEMBL468513	479181	CHEMBL468513	479181		43	460.61	4.04	78.08	0	CN1CCC(CC1)C(=O)N[C@@H](CCCCCC(=O)C)c2ncc([nH]2)c3ccc4ccccc4c3	2259883	IC50	=	29	nM	7.54			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	496826	CHEMBL1008839	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			45815	CHEMBL1152225	18809328	Bioorg. Med. Chem. Lett.	2008	18	20	5528			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	1, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	2259884	IC50	=	82	nM	7.09			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	496826	CHEMBL1008839	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			45815	CHEMBL1152225	18809328	Bioorg. Med. Chem. Lett.	2008	18	20	5528			
CHEMBL598797	603809	CHEMBL598797	603809	CUDC-101	8, CDUC-101	434.49	5.38	105.6	1	COc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCCCCCC(=O)NO	3121081	IC50	=	12.6	nM	7.9			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	612329	CHEMBL1065581	B	Inhibition of human HDAC2 expressed in Escherichia coli	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	49662	CHEMBL1157563	20143778	J. Med. Chem.	2010	53	5	2000			
CHEMBL1800241	1161304	CHEMBL1800241	1161304		7, BRD-2577	317.36	2.07	117.48	0	CC(=O)Nc1ccc(cc1)C(=O)CSc2nc(C)cc(O)n2	6283246	Inhibition					Active		0	BAO_0000376			757642	CHEMBL1805037	B	Competitive inhibition of HDAC2 active site at 1 to 100 uM by Lineweaver-Burk plot	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL1812334	1167356	CHEMBL1812334	1167356		3	407.84	2.61	66.64	0	N[C@H](Cc1cccc(Cl)c1)C(=O)N2CCN(CC2)C(=O)c3cc(F)ccc3F	6314702	IC50	>	30000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	761695	CHEMBL1816687	B	Inhibition of human HDAC2 using rhodamine as substrate after 1 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			58554	CHEMBL1811912	21723733	Bioorg. Med. Chem.	2011	19	15	4626			
CHEMBL1771486	1143797	CHEMBL1771486	1143797		A8B4	568.62	3.91	137.4	1	ONC(=O)c1cccc(c1)C(=O)N\N=C\c2cccc(CN3C[C@H](OC(=O)CC\C=C\CCC3=O)c4ccccc4)c2	6182569	IC50	=	3600	nM	5.44			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	744275	CHEMBL1772082	B	Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			57403	CHEMBL1770095	21334896	Bioorg. Med. Chem. Lett.	2011	21	9	2601			
CHEMBL1800241	1161304	CHEMBL1800241	1161304		7, BRD-2577	317.36	2.07	117.48	0	CC(=O)Nc1ccc(cc1)C(=O)CSc2nc(C)cc(O)n2	6283030	IC50	=	18900	nM	4.72			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL1800243	1161306	CHEMBL1800243	1161306		9	331.39	2.3	106.48	0	COc1cc(C)nc(SCC(=O)c2ccc(NC(=O)C)cc2)n1	6283032	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL1800247	1161310	CHEMBL1800247	1161310		13	300.31	2.36	88.52	0	CC(=O)Nc1ccc(cc1)C(=O)COc2cc(C)cc(O)n2	6283036	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL1800374	1161438	CHEMBL1800374	1161438		20	316.42	4.35	88.38	0	Cc1cc(O)nc(SCC(=O)c2ccc(cc2)C(C)(C)C)n1	6283043	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL209453	347865	CHEMBL209453	347865		23	292.31	2.47	128.84	0	Cc1cc(O)nc(SCC(=O)c2ccc(O)c(O)c2)n1	6283046	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL1800377	1161441	CHEMBL1800377	1161441		24	318.35	2.74	106.84	0	Cc1cc(O)nc(SCC(=O)c2ccc3OCCOc3c2)n1	6283047	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	1, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	10981402	IC50	=	180	nM	6.74			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	831128	CHEMBL2065941	B	Inhibition of recombinant HDAC2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			62769	CHEMBL2062402		ACS Med. Chem. Lett.	2012	3	6	505			
CHEMBL2057820	1353575	CHEMBL2057820	1353575		2a	492.53	5.43	143.19	1	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cccc(c3)N=[N+]=[N-])cc2)c4ccccc4	10955018	Inhibition					tde		0	BAO_0000376			829163	CHEMBL2059985	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057821	1353576	CHEMBL2057821	1353576		2b	547.57	6.13	192.95	2	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2)c4ccccc4	10955019	Inhibition					tde		0	BAO_0000376			829163	CHEMBL2059985	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057825	1353580	CHEMBL2057825	1353580		1c	390.42	4.73	182.86	0	Nc1ccc(cc1NC(=O)c2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c3cccs3	10955021	Activity					Active		0	BAO_0000375			829164	CHEMBL2059986	B	Binding affinity to His-tagged human HDAC2 assessed as decrease in biotinylation of HDAC2 at 25 uM preincubated for 24 hrs measured after 1 hr by Western blot analysis in presence of five-fold molar excess of Trichostatin A	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057827	1353582	CHEMBL2057827	1353582		1e	414.42	4.82	163.85	0	Nc1ccc(cc1NC(=O)c2ccc(OCCN=[N+]=[N-])c(c2)N=[N+]=[N-])c3ccccc3	10955023	Activity					Active		0	BAO_0000375			829164	CHEMBL2059986	B	Binding affinity to His-tagged human HDAC2 assessed as decrease in biotinylation of HDAC2 at 25 uM preincubated for 24 hrs measured after 1 hr by Western blot analysis in presence of five-fold molar excess of Trichostatin A	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057828	1353583	CHEMBL2057828	1353583		1f	420.45	4.78	192.09	0	Nc1ccc(cc1NC(=O)c2ccc(OCCN=[N+]=[N-])c(c2)N=[N+]=[N-])c3cccs3	10955024	Activity					Active		0	BAO_0000375			829164	CHEMBL2059986	B	Binding affinity to His-tagged human HDAC2 assessed as decrease in biotinylation of HDAC2 at 25 uM preincubated for 24 hrs measured after 1 hr by Western blot analysis in presence of five-fold molar excess of Trichostatin A	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057821	1353576	CHEMBL2057821	1353576		2b	547.57	6.13	192.95	2	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2)c4ccccc4	10955026	Activity					Active		0	BAO_0000375			829164	CHEMBL2059986	B	Binding affinity to His-tagged human HDAC2 assessed as decrease in biotinylation of HDAC2 at 25 uM preincubated for 24 hrs measured after 1 hr by Western blot analysis in presence of five-fold molar excess of Trichostatin A	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057823	1353578	CHEMBL2057823	1353578		1a	329.36	4.08	104.87	0	Nc1ccc(cc1NC(=O)c2ccc(cc2)N=[N+]=[N-])c3ccccc3	10955037	Inhibition					Active		0	BAO_0000376			829166	CHEMBL2059988	B	Inhibition of HDAC2 in human MDA-MB-231 cells assessed as inhibition of H4 deacetylation at 50 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025	325	CHEMBL3307960	MDA-MB-231
CHEMBL2057825	1353580	CHEMBL2057825	1353580		1c	390.42	4.73	182.86	0	Nc1ccc(cc1NC(=O)c2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c3cccs3	10955039	Inhibition					Active		0	BAO_0000376			829166	CHEMBL2059988	B	Inhibition of HDAC2 in human MDA-MB-231 cells assessed as inhibition of H4 deacetylation at 50 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025	325	CHEMBL3307960	MDA-MB-231
CHEMBL2057827	1353582	CHEMBL2057827	1353582		1e	414.42	4.82	163.85	0	Nc1ccc(cc1NC(=O)c2ccc(OCCN=[N+]=[N-])c(c2)N=[N+]=[N-])c3ccccc3	10955041	Inhibition					Active		0	BAO_0000376			829166	CHEMBL2059988	B	Inhibition of HDAC2 in human MDA-MB-231 cells assessed as inhibition of H4 deacetylation at 50 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025	325	CHEMBL3307960	MDA-MB-231
CHEMBL2057828	1353583	CHEMBL2057828	1353583		1f	420.45	4.78	192.09	0	Nc1ccc(cc1NC(=O)c2ccc(OCCN=[N+]=[N-])c(c2)N=[N+]=[N-])c3cccs3	10955042	Inhibition					Active		0	BAO_0000376			829166	CHEMBL2059988	B	Inhibition of HDAC2 in human MDA-MB-231 cells assessed as inhibition of H4 deacetylation at 50 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025	325	CHEMBL3307960	MDA-MB-231
CHEMBL2057820	1353575	CHEMBL2057820	1353575		2a	492.53	5.43	143.19	1	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cccc(c3)N=[N+]=[N-])cc2)c4ccccc4	10955043	Inhibition					Active		0	BAO_0000376			829166	CHEMBL2059988	B	Inhibition of HDAC2 in human MDA-MB-231 cells assessed as inhibition of H4 deacetylation at 50 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025	325	CHEMBL3307960	MDA-MB-231
CHEMBL2057821	1353576	CHEMBL2057821	1353576		2b	547.57	6.13	192.95	2	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2)c4ccccc4	10955044	Inhibition					Active		0	BAO_0000376			829166	CHEMBL2059988	B	Inhibition of HDAC2 in human MDA-MB-231 cells assessed as inhibition of H4 deacetylation at 50 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025	325	CHEMBL3307960	MDA-MB-231
CHEMBL2057828	1353583	CHEMBL2057828	1353583		1f	420.45	4.78	192.09	0	Nc1ccc(cc1NC(=O)c2ccc(OCCN=[N+]=[N-])c(c2)N=[N+]=[N-])c3cccs3	10954404	Ratio IC50	=	2.6					0	BAO_0000179			829156	CHEMBL2059978	B	Ratio of IC50 for human HDAC2 preincubated for 3 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057823	1353578	CHEMBL2057823	1353578		1a	329.36	4.08	104.87	0	Nc1ccc(cc1NC(=O)c2ccc(cc2)N=[N+]=[N-])c3ccccc3	10954399	Ratio IC50	=	4.9					0	BAO_0000179			829156	CHEMBL2059978	B	Ratio of IC50 for human HDAC2 preincubated for 3 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057825	1353580	CHEMBL2057825	1353580		1c	390.42	4.73	182.86	0	Nc1ccc(cc1NC(=O)c2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c3cccs3	10954401	Ratio IC50	=	3.5					0	BAO_0000179			829156	CHEMBL2059978	B	Ratio of IC50 for human HDAC2 preincubated for 3 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057827	1353582	CHEMBL2057827	1353582		1e	414.42	4.82	163.85	0	Nc1ccc(cc1NC(=O)c2ccc(OCCN=[N+]=[N-])c(c2)N=[N+]=[N-])c3ccccc3	10954403	Ratio IC50	=	5.2					0	BAO_0000179			829156	CHEMBL2059978	B	Ratio of IC50 for human HDAC2 preincubated for 3 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057820	1353575	CHEMBL2057820	1353575		2a	492.53	5.43	143.19	1	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cccc(c3)N=[N+]=[N-])cc2)c4ccccc4	10954406	Ratio IC50	=	3.8					0	BAO_0000179			829156	CHEMBL2059978	B	Ratio of IC50 for human HDAC2 preincubated for 3 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057821	1353576	CHEMBL2057821	1353576		2b	547.57	6.13	192.95	2	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2)c4ccccc4	10954407	Ratio IC50	=	6.4					0	BAO_0000179			829156	CHEMBL2059978	B	Ratio of IC50 for human HDAC2 preincubated for 3 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	10954409	Ratio IC50					Not Determined		0	BAO_0000179			829156	CHEMBL2059978	B	Ratio of IC50 for human HDAC2 preincubated for 3 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057823	1353578	CHEMBL2057823	1353578		1a	329.36	4.08	104.87	0	Nc1ccc(cc1NC(=O)c2ccc(cc2)N=[N+]=[N-])c3ccccc3	10954412	Ratio IC50	=	24					0	BAO_0000179			829157	CHEMBL2059979	B	Ratio of IC50 for human HDAC2 preincubated for 24 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057825	1353580	CHEMBL2057825	1353580		1c	390.42	4.73	182.86	0	Nc1ccc(cc1NC(=O)c2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c3cccs3	10954414	Ratio IC50	=	7.5					0	BAO_0000179			829157	CHEMBL2059979	B	Ratio of IC50 for human HDAC2 preincubated for 24 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057827	1353582	CHEMBL2057827	1353582		1e	414.42	4.82	163.85	0	Nc1ccc(cc1NC(=O)c2ccc(OCCN=[N+]=[N-])c(c2)N=[N+]=[N-])c3ccccc3	10954416	Ratio IC50	=	41					0	BAO_0000179			829157	CHEMBL2059979	B	Ratio of IC50 for human HDAC2 preincubated for 24 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057828	1353583	CHEMBL2057828	1353583		1f	420.45	4.78	192.09	0	Nc1ccc(cc1NC(=O)c2ccc(OCCN=[N+]=[N-])c(c2)N=[N+]=[N-])c3cccs3	10954417	Ratio IC50	=	23					0	BAO_0000179			829157	CHEMBL2059979	B	Ratio of IC50 for human HDAC2 preincubated for 24 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057820	1353575	CHEMBL2057820	1353575		2a	492.53	5.43	143.19	1	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cccc(c3)N=[N+]=[N-])cc2)c4ccccc4	10954419	Ratio IC50	=	12					0	BAO_0000179			829157	CHEMBL2059979	B	Ratio of IC50 for human HDAC2 preincubated for 24 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057821	1353576	CHEMBL2057821	1353576		2b	547.57	6.13	192.95	2	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2)c4ccccc4	10954420	Ratio IC50	=	20					0	BAO_0000179			829157	CHEMBL2059979	B	Ratio of IC50 for human HDAC2 preincubated for 24 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	10954422	Ratio IC50	=	.77					0	BAO_0000179			829157	CHEMBL2059979	B	Ratio of IC50 for human HDAC2 preincubated for 24 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057823	1353578	CHEMBL2057823	1353578		1a	329.36	4.08	104.87	0	Nc1ccc(cc1NC(=O)c2ccc(cc2)N=[N+]=[N-])c3ccccc3	10954449	Inhibition					tde		0	BAO_0000376			829163	CHEMBL2059985	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057825	1353580	CHEMBL2057825	1353580		1c	390.42	4.73	182.86	0	Nc1ccc(cc1NC(=O)c2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c3cccs3	10954451	Inhibition					tde		0	BAO_0000376			829163	CHEMBL2059985	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057827	1353582	CHEMBL2057827	1353582		1e	414.42	4.82	163.85	0	Nc1ccc(cc1NC(=O)c2ccc(OCCN=[N+]=[N-])c(c2)N=[N+]=[N-])c3ccccc3	10954453	Inhibition					tde		0	BAO_0000376			829163	CHEMBL2059985	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057828	1353583	CHEMBL2057828	1353583		1f	420.45	4.78	192.09	0	Nc1ccc(cc1NC(=O)c2ccc(OCCN=[N+]=[N-])c(c2)N=[N+]=[N-])c3cccs3	10954454	Inhibition					tde		0	BAO_0000376			829163	CHEMBL2059985	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057820	1353575	CHEMBL2057820	1353575		2a	492.53	5.43	143.19	1	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cccc(c3)N=[N+]=[N-])cc2)c4ccccc4	10954289	IC50	=	1000	nM	6			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829147	CHEMBL2059969	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 3 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2012815	1333878	CHEMBL2012815	1333878		15	578.74	3.85	133.47	1	CCC(=O)CCCCC[C@@H]1NC(=O)[C@H](C)NC(=O)C[C@H](CC(C)C)NC(=O)[C@H](Cc2cccc3ccccc23)NC1=O	10839294	IC50	=	290	nM	6.54			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	812549	CHEMBL2014424	B	Inhibition of recombinant human HDAC2 using Fluor-de-Lys as substrate after 30 mins by spectrophotometry	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	61427	CHEMBL2010669		ACS Med. Chem. Lett.	2011	2	9	703			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	2, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	10839295	IC50	=	66	nM	7.18			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	812549	CHEMBL2014424	B	Inhibition of recombinant human HDAC2 using Fluor-de-Lys as substrate after 30 mins by spectrophotometry	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	61427	CHEMBL2010669		ACS Med. Chem. Lett.	2011	2	9	703			
CHEMBL2057823	1353578	CHEMBL2057823	1353578		1a	329.36	4.08	104.87	0	Nc1ccc(cc1NC(=O)c2ccc(cc2)N=[N+]=[N-])c3ccccc3	10954269	IC50	=	5130	nM	5.29			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829146	CHEMBL2059968	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 5 mins measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057825	1353580	CHEMBL2057825	1353580		1c	390.42	4.73	182.86	0	Nc1ccc(cc1NC(=O)c2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c3cccs3	10954271	IC50	=	18000	nM	4.74			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829146	CHEMBL2059968	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 5 mins measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057827	1353582	CHEMBL2057827	1353582		1e	414.42	4.82	163.85	0	Nc1ccc(cc1NC(=O)c2ccc(OCCN=[N+]=[N-])c(c2)N=[N+]=[N-])c3ccccc3	10954273	IC50	=	34000	nM	4.47			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829146	CHEMBL2059968	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 5 mins measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057828	1353583	CHEMBL2057828	1353583		1f	420.45	4.78	192.09	0	Nc1ccc(cc1NC(=O)c2ccc(OCCN=[N+]=[N-])c(c2)N=[N+]=[N-])c3cccs3	10954274	IC50	=	17000	nM	4.77			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829146	CHEMBL2059968	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 5 mins measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057820	1353575	CHEMBL2057820	1353575		2a	492.53	5.43	143.19	1	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cccc(c3)N=[N+]=[N-])cc2)c4ccccc4	10954276	IC50	=	3800	nM	5.42			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829146	CHEMBL2059968	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 5 mins measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057821	1353576	CHEMBL2057821	1353576		2b	547.57	6.13	192.95	2	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2)c4ccccc4	10954277	IC50	=	7000	nM	5.15			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829146	CHEMBL2059968	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 5 mins measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	10954279	IC50	=	200	nM	6.7			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829146	CHEMBL2059968	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 5 mins measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057823	1353578	CHEMBL2057823	1353578		1a	329.36	4.08	104.87	0	Nc1ccc(cc1NC(=O)c2ccc(cc2)N=[N+]=[N-])c3ccccc3	10954282	IC50	=	1050	nM	5.98			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829147	CHEMBL2059969	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 3 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057825	1353580	CHEMBL2057825	1353580		1c	390.42	4.73	182.86	0	Nc1ccc(cc1NC(=O)c2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c3cccs3	10954284	IC50	=	5200	nM	5.28			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829147	CHEMBL2059969	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 3 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057827	1353582	CHEMBL2057827	1353582		1e	414.42	4.82	163.85	0	Nc1ccc(cc1NC(=O)c2ccc(OCCN=[N+]=[N-])c(c2)N=[N+]=[N-])c3ccccc3	10954286	IC50	=	6500	nM	5.19			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829147	CHEMBL2059969	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 3 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057828	1353583	CHEMBL2057828	1353583		1f	420.45	4.78	192.09	0	Nc1ccc(cc1NC(=O)c2ccc(OCCN=[N+]=[N-])c(c2)N=[N+]=[N-])c3cccs3	10954287	IC50	=	6600	nM	5.18			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829147	CHEMBL2059969	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 3 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057821	1353576	CHEMBL2057821	1353576		2b	547.57	6.13	192.95	2	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2)c4ccccc4	10954290	IC50	=	1100	nM	5.96			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829147	CHEMBL2059969	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 3 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	10954292	IC50					Not Determined		0	BAO_0000190			829147	CHEMBL2059969	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 3 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057823	1353578	CHEMBL2057823	1353578		1a	329.36	4.08	104.87	0	Nc1ccc(cc1NC(=O)c2ccc(cc2)N=[N+]=[N-])c3ccccc3	10954295	IC50	=	210	nM	6.68			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829148	CHEMBL2059970	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 24 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057825	1353580	CHEMBL2057825	1353580		1c	390.42	4.73	182.86	0	Nc1ccc(cc1NC(=O)c2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c3cccs3	10954297	IC50	=	2400	nM	5.62			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829148	CHEMBL2059970	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 24 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057827	1353582	CHEMBL2057827	1353582		1e	414.42	4.82	163.85	0	Nc1ccc(cc1NC(=O)c2ccc(OCCN=[N+]=[N-])c(c2)N=[N+]=[N-])c3ccccc3	10954299	IC50	=	830	nM	6.08			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829148	CHEMBL2059970	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 24 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057828	1353583	CHEMBL2057828	1353583		1f	420.45	4.78	192.09	0	Nc1ccc(cc1NC(=O)c2ccc(OCCN=[N+]=[N-])c(c2)N=[N+]=[N-])c3cccs3	10954300	IC50	=	750	nM	6.12			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829148	CHEMBL2059970	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 24 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057820	1353575	CHEMBL2057820	1353575		2a	492.53	5.43	143.19	1	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cccc(c3)N=[N+]=[N-])cc2)c4ccccc4	10954302	IC50	=	320	nM	6.49			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829148	CHEMBL2059970	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 24 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL2057821	1353576	CHEMBL2057821	1353576		2b	547.57	6.13	192.95	2	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cc(CN=[N+]=[N-])cc(c3)N=[N+]=[N-])cc2)c4ccccc4	10954303	IC50	=	350	nM	6.46			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829148	CHEMBL2059970	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 24 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	10954305	IC50	=	260	nM	6.59			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829148	CHEMBL2059970	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 24 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL1851943	1192622	CHEMBL1851943	1192622		21, SB939	358.48	3.71	70.39	0	CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(CC)CC	14927528	Ki	=	16	nM	7.8			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	1390369	CHEMBL3391447	B	Inhibition of recombinant human HDAC-2 expressed in baculovirus infected insect Sf9 cells using Fluor de Lys as substrate preincubated for 2 hrs followed by substrate addition measured after 10 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		85880	CHEMBL3390834		MedChemComm	2012	3	2	135			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	13878335	IC50	=	110	nM	6.96			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1284313	CHEMBL3108334	B	Inhibition of recombinant HDAC2 (unknown origin) using Fluor-de-Lys-SIRT1 as substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76491	CHEMBL3102702	24328302	J. Nat. Prod.	2014	77	1	49			
CHEMBL3104855	1612941	CHEMBL3104855	1612941		10	358.3	3.22	148.43	0	Cc1c(O)c(O)c2oc(cc2c1C=O)c3c(C)c(O)c(O)c(O)c3C=O	13878336	IC50	=	9100	nM	5.04			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1284313	CHEMBL3108334	B	Inhibition of recombinant HDAC2 (unknown origin) using Fluor-de-Lys-SIRT1 as substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76491	CHEMBL3102702	24328302	J. Nat. Prod.	2014	77	1	49			
CHEMBL3104851	1612937	CHEMBL3104851	1612937		1	374.3	2.3	153.74	0	Cc1c(O)c(O)c2O[C@H]3O[C@H](C(=O)c4c(O)c(O)c(O)c(C)c34)c2c1C=O	13878337	IC50	=	10000	nM	5			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1284313	CHEMBL3108334	B	Inhibition of recombinant HDAC2 (unknown origin) using Fluor-de-Lys-SIRT1 as substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76491	CHEMBL3102702	24328302	J. Nat. Prod.	2014	77	1	49			
CHEMBL3110023	1615229	CHEMBL3110023	1615229		33	257.29	1.16	67.15	0	Cn1cc(cn1)[C@H]2[C@@H]([C@@H]2c3ccccc3)C(=O)NO	13896924	IC50	>	50000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1287880	CHEMBL3112164	B	Inhibition of human recombinant full length HDAC2 using (Ac)Arg-Gly-Lys(Ac) as substrate after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			76664	CHEMBL3108758	24261862	J. Med. Chem.	2013	56	24	9934			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	4, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	13896926	IC50	=	920	nM	6.04			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1287880	CHEMBL3112164	B	Inhibition of human recombinant full length HDAC2 using (Ac)Arg-Gly-Lys(Ac) as substrate after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76664	CHEMBL3108758	24261862	J. Med. Chem.	2013	56	24	9934			
CHEMBL3110281	1615489	CHEMBL3110281	1615489		14e	365.45	3.52	110.06	0	OC1=CC=CN(CCCCCn2cc(nn2)c3cccc(c3)C#N)C1=S	13890343	IC50	=	3680	nM	5.43			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1286645	CHEMBL3111120	B	Inhibition of HDAC2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using GRKacYGC as substrate after 60 mins by SAMDI mass spectrometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76678	CHEMBL3108745	24304348	J. Med. Chem.	2013	56	24	9969			
CHEMBL3098687	1609458	CHEMBL3098687	1609458		16	432.51	1.19	136.63	0	ONC(=O)CCCCC[C@H](NC(=O)[C@@H]1CCCC(=O)N1)C(=O)NCCc2ccccc2	13867796	IC50	=	956	nM	6.02			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL1089495	621496	CHEMBL1089495	621496		32	332.32	2.95	78.43	0	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)C(F)(F)F	13867803	IC50	=	165	nM	6.78			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL3098692	1609463	CHEMBL3098692	1609463		12	404.46	.85	136.63	0	ONC(=O)CCCCC[C@H](NC(=O)C1CCCNC1=O)C(=O)Nc2ccccc2	13867809	IC50	=	689	nM	6.16			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA, Vorinostat	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	13867813	IC50	=	921	nM	6.04			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL484489	500081	CHEMBL484489	500081		37	328.77	2.72	78.43	0	ONC(=O)CCCCCNC(=O)\C=C\c1ccc(Cl)cc1F	2306401	IC50	=	3	nM	8.52			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	521104	CHEMBL960365	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46897	CHEMBL1137690	18672316	Eur. J. Med. Chem.	2009	44	3	1067			
CHEMBL519943	474721	CHEMBL519943	474721		7e	393.46	3.1	109.91	0	ONC(=O)c1ccc(CN2[C@@H](Cc3cccs3)C(=O)Nc4ccccc24)cc1	2489478	IC50	=	1480	nM	5.83			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	515266	CHEMBL991290	B	Inhibition of human recombinant histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45582	CHEMBL1143301	19111466	Bioorg. Med. Chem. Lett.	2009	19	3	688			
CHEMBL481018	474661	CHEMBL481018	474661		7f	423.41	3.85	81.67	0	ONC(=O)c1ccc(CN2[C@H](Cc3ccc(F)c(F)c3)C(=O)Nc4ccccc24)cc1	2489479	IC50	=	460	nM	6.34			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	515266	CHEMBL991290	B	Inhibition of human recombinant histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45582	CHEMBL1143301	19111466	Bioorg. Med. Chem. Lett.	2009	19	3	688			
CHEMBL483892	508339	CHEMBL483892	508339		10b	439.48	3.92	109.14	0	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)c2cn(Cc3ccc(F)cc3)nn2	2351864	IC50	=	77.4	nM	7.11			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL483494	508153	CHEMBL483494	508153		6b	439.48	3.92	109.14	0	ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)c2cn(Cc3ccc(F)cc3)nn2	2351868	IC50	=	294	nM	6.53			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL1213459	685303	CHEMBL1213459	685303	DEPUDECIN	Depudecin	212.24	.08	65.52	0	C[C@@H](O)[C@H]1O[C@H]1\C=C\[C@@H]2O[C@H]2[C@H](O)C=C	3389931	Ki	=	12500	nM	4.9			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL1800244	1161307	CHEMBL1800244	1161307		10	315.39	2.06	97.25	0	CC(=O)Nc1ccc(cc1)C(=O)CSc2nc(C)cc(C)n2	6283033	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL1800249	1161312	CHEMBL1800249	1161312		15	319.38	1.89	120.64	0	CC(=O)Nc1ccc(cc1)C(O)CSc2nc(C)cc(O)n2	6283038	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL1834367	1178411	CHEMBL1834367	1178411		TM-2-104	284.38	3.87	73.22	0	C[C@H](NC(=S)NC(=O)c1ccccc1)c2ccccc2	6376233	Inhibition	=	5	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	771822	CHEMBL1838694	B	Inhibition of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL2333345	1522983	CHEMBL2333345	1522983		13	143.18	1.31	49.33	0	ONC(=O)C1CCCCC1	12680989	IC50	>	33330	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	944722	CHEMBL2340968	B	Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772			
CHEMBL2347009	1528833	CHEMBL2347009	1528833		15, rosuva-HA	496.55	1.81	161.32	0	CC(C)c1nc(nc(c1\C=C\[C@@H](O)C[C@@H](O)CC(=O)NO)c2ccc(F)cc2)N(C)S(=O)(=O)C	12718181	IC50	=	600.1	nM	6.22			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	950484	CHEMBL2351477	B	Inhibition of recombinant HDAC2 (unknown origin) after 10 mins by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72873	CHEMBL2346500	23570542	J. Med. Chem.	2013	56	9	3645			
CHEMBL2381521	1560931	CHEMBL2381521	1560931		7	194.19	.05	78.43	0	CNC(=O)c1cccc(c1)C(=O)NO	13297584	IC50	>	33000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	958899	CHEMBL2384807	B	Inhibition of HDAC2 (unknown origin) after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			73668	CHEMBL2380312	23672185	J. Med. Chem.	2013	56	11	4816			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	Zolinza, NSC 701852	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	13395542	IC50	=	232	nM	6.63			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	972661	CHEMBL2410764	B	Inhibition of HDAC2 (unknown origin) using fluorogenic peptide from p53 residues (379 to 382) (RHKK(Ac)) as substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74303	CHEMBL2406958		ACS Med. Chem. Lett.	2013	4	8	779			
CHEMBL1938433	1273267	CHEMBL1938433	1273267		1	392.45	2.52	78.87	0	ONC(=O)\C=C\c1ccc2OC3(CCN(Cc4ccccc4)CC3)CC(=O)c2c1	13337988	IC50	=	270	nM	6.57			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	964225	CHEMBL2395195	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	73929	CHEMBL2390828	23644210	Eur. J. Med. Chem.	2013	64		273			
CHEMBL1173445	651590	CHEMBL1173445	651590	LARGAZOLE	Largazole	622.86	5.17	205.66	2	CCCCCCCC(=O)SCC\C=C\[C@@H]1CC(=O)NCc2nc(cs2)C3=N[C@@](C)(CS3)C(=O)N[C@@H](C(C)C)C(=O)O1	13472698	IC50	=	900	nM	6.05			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	988355	CHEMBL2437618	B	Inhibition of HDAC2 (unknown origin) using MAZ1600 and MAZ1675 as substrate assessed as fluorogenic release of 7-amino-4-methylcoumarin from substrate by optimized homogenous assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	75140	CHEMBL2434914	24035339	Bioorg. Med. Chem. Lett.	2013	23	21	6025			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	1, TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	13348855	Activity	=	.07	%				0	BAO_0001103	UO_0000187	http://qudt.org/vocab/unit#Percent	967676	CHEMBL2399518	B	Inhibition of recombinant human HDAC2 using Arg-His-Lys-Lys(Ac) as substrate assessed as residual activity at 3.3 x 10'-5 M after 2 hrs by fluorescence assay relative to control	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74058	CHEMBL2396570	23693069	Bioorg. Med. Chem.	2013	21	13	3795			
CHEMBL1560	444750	CHEMBL1560	444750	CAPTOPRIL	Captopril, Capoten	217.29	.67	96.41	0	C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O	13488739	Inhibition					Not Active		0	BAO_0000376			987733	CHEMBL2439711	B	Inhibition of HDAC2 (unknown origin)-mediated deacetylation at 10 uM preincubated for 5 mins prior to substrate addition measured after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75182	CHEMBL2434956	24074025	J. Med. Chem.	2013	56	20	7997			
CHEMBL3109983	1615188	CHEMBL3109983	1615188		57	390.36	2.68	69.64	0	ONC(=O)[C@@H]1[C@@H]([C@H]1c2ccc3C(=O)N(CC(F)(F)F)Cc3c2)c4ccccc4	13896921	IC50	>	50000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1287880	CHEMBL3112164	B	Inhibition of human recombinant full length HDAC2 using (Ac)Arg-Gly-Lys(Ac) as substrate after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			76664	CHEMBL3108758	24261862	J. Med. Chem.	2013	56	24	9934			
CHEMBL3098696	1609467	CHEMBL3098696	1609467		31	256.34	1.83	78.43	0	ONC(=O)CCCCCCC(=O)NC1CCCC1	13867805	IC50	=	4390	nM	5.36			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL2347006	1528830	CHEMBL2347006	1528830		12, lova-HA	437.57	3.02	116.09	0	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)NO)[C@@H]12	12718184	IC50	=	468.3	nM	6.33			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	950484	CHEMBL2351477	B	Inhibition of recombinant HDAC2 (unknown origin) after 10 mins by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72873	CHEMBL2346500	23570542	J. Med. Chem.	2013	56	9	3645			
CHEMBL2425965	1581084	CHEMBL2425965	1581084		3m	393.44	3.07	91.23	0	CCC1=Nc2cc(\C=C\C(=O)NO)ccc2C(=O)N1CCc3ccc(OC)cc3	13451916	IC50	=	4780	nM	5.32			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL2425954	1581073	CHEMBL2425954	1581073		3b	321.33	2.09	82	0	CC1=Nc2ccc(\C=C\C(=O)NO)cc2C(=O)N1c3ccccc3	13451929	IC50	=	7480	nM	5.13			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	1, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	13431790	Ki	=	7	nM	8.15			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	979441	CHEMBL2423477	B	Inhibition of recombinant human HDAC2 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74596	CHEMBL2417416	23865683	J. Med. Chem.	2013	56	16	6512			
CHEMBL2390995	1564562	CHEMBL2390995	1564562		2	410.44	2.73	78.87	0	ONC(=O)\C=C\c1ccc2OC3(CCN(Cc4ccc(F)cc4)CC3)CC(=O)c2c1	13337968	IC50	=	310	nM	6.51			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	964225	CHEMBL2395195	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	73929	CHEMBL2390828	23644210	Eur. J. Med. Chem.	2013	64		273			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	13338007	IC50	=	197	nM	6.71			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	964225	CHEMBL2395195	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	73929	CHEMBL2390828	23644210	Eur. J. Med. Chem.	2013	64		273			
CHEMBL2396901	1567407	CHEMBL2396901	1567407		Sdelta, SAHA-PIP-delta	1598.73				CN(C)CCCNC(=O)c1cc(NC(=O)c2cc(NC(=O)c3cc(NC(=O)c4nc(NC(=O)CCCNC(=O)c5cc(NC(=O)c6cc(NC(=O)c7cc(NC(=O)c8nc(NC(=O)CCNC(=O)CCNC(=O)c9ccc(NC(=O)CCCCCCC(=O)NO)cc9)cn8C)cn7C)cn6C)cn5C)cn4C)cn3C)cn2C)cn1C	13361786	IC50	=	770	nM	6.11			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	967402	CHEMBL2401043	B	Inhibition of HDAC2 (unknown origin) after 30 mins by fluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74085	CHEMBL2396564	23719282	Bioorg. Med. Chem.	2013	21	14	4201			
CHEMBL20	1125	CHEMBL20	1125	ACETAZOLAMIDE	Acetazolamide, Diamox	222.25	-1.33	151.65	0	CC(=O)Nc1nnc(s1)S(=O)(=O)N	13488740	Inhibition					Not Active		0	BAO_0000376			987733	CHEMBL2439711	B	Inhibition of HDAC2 (unknown origin)-mediated deacetylation at 10 uM preincubated for 5 mins prior to substrate addition measured after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75182	CHEMBL2434956	24074025	J. Med. Chem.	2013	56	20	7997			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	2, SAHA, Vorinostat	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	13838872	IC50	=	85.8	nM	7.07			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1276444	CHEMBL3088540	B	Inhibition of human recombinant HDAC2 after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76042	CHEMBL3085682	24164245	J. Nat. Prod.	2013	76	11	2026			
CHEMBL3235463	1733986	CHEMBL3235463	1733986		2b	389.49	5	69.56	0	ONC(=O)\C=C\c1ccc(cc1)c2ccc(O)c(c2)C34CC5CC(CC(C5)C3)C4	14570790	IC50	=	2640	nM	5.58			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1335247	CHEMBL3238600	B	Inhibition of HDAC2 in human HeLa cells using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82343	CHEMBL3232764	24742384	Eur. J. Med. Chem.	2014	79		251			
CHEMBL3526942	1924644	CHEMBL3526942	1924644		M7	349.43	2.94	91.14	0	Cc1[nH]c2cc(O)ccc2c1CCNCc3ccc(\C=C\C(=O)N)cc3	15462099	IC50	=	27000	nM	4.57			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1484269	CHEMBL3538485	B	Inhibition of flag-tagged HDAC2 (unknown origin) expressed in SF21 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation counting	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91925	CHEMBL3526051	22344701	Drug Metab. Dispos.	2012	40	5	1041			
CHEMBL3353927	1818040	CHEMBL3353927	1818040		89, ST8081	431.47	2.53	126.1	0	FC(F)(F)c1cccc(NC(=O)[C@H](CCCCCS)NC(=O)[C@H]2CCC(=O)N2)c1	15138230	IC50	=	12	nM	7.92			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3335300	1791433	CHEMBL3335300	1791433		22	349.43	4.01	67.15	0	ONC(=O)CCCCc1ccn(Cc2ccc(cc2)c3ccccc3)n1	15086179	IC50	=	226	nM	6.65			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1433878	CHEMBL3388839	B	Inhibition of human recombinant HDAC2 after 60 mins by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89339	CHEMBL3352093	25218912	Eur. J. Med. Chem.	2014	86		639			
CHEMBL3318732	1783380	CHEMBL3318732	1783380		7d	392.4	4.14	71.06	0	COc1ccc2C=C(C(=O)\C=C\C=C\c3ccc(OC)c(OC)c3)C(=O)Oc2c1	14998997	IC50	=	33000	nM	4.48			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1458440	CHEMBL3370095	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90539	CHEMBL3351243	25042254	Bioorg. Med. Chem. Lett.	2014	24	16	3797			
CHEMBL3427752	1845148	CHEMBL3427752	1845148		3h	320.18	3.33	71.77	0	NC(=O)C1CCCc2c1[nH]nc2c3ccc(Br)cc3	15255902	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL3427765	1845161	CHEMBL3427765	1845161		3u	376.27	4.48	100.01	0	NC(=O)C1CCCc2c1[nH]nc2c3cc4cc(Br)ccc4s3	15255967	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL152665	256929	CHEMBL152665	256929	PHENYLACETOHYDROXAMIC ACID	9	151.16	.88	49.33	0	ONC(=O)Cc1ccccc1	12680993	IC50	>	33330	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	944722	CHEMBL2340968	B	Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772			
CHEMBL2336043	1525709	CHEMBL2336043	1525709		17a	507.62	5.65	112.68	2	CCCC(CCC)C(=O)N[C@H](COc1ccc(\C=C\C(=O)NO)cc1OC)Cc2c[nH]c3ccccc23	12685381	IC50	=	1420	nM	5.85			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	945444	CHEMBL2342555	B	Inhibition of HDAC2 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate preincubated with enzyme for 5 mins prior to substrate addition measured after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72255	CHEMBL2331319		ACS Med. Chem. Lett.	2013	4	2	235			
CHEMBL2312168	1511212	CHEMBL2312168	1511212		19i, LMK235	294.35	2.2	87.66	0	Cc1cc(C)cc(c1)C(=O)NOCCCCCC(=O)NO	12622655	IC50	=	881	nM	6.06			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	936031	CHEMBL2318997	B	Inhibition of human HDAC2 by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	71849	CHEMBL2311425	23252603	J. Med. Chem.	2013	56	2	427			
CHEMBL2381523	1560933	CHEMBL2381523	1560933		9	242.27	2.24	61.36	0	ONC(=O)c1cccc(CNc2ccccc2)c1	13297582	IC50	>	33000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	958899	CHEMBL2384807	B	Inhibition of HDAC2 (unknown origin) after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			73668	CHEMBL2380312	23672185	J. Med. Chem.	2013	56	11	4816			
CHEMBL511749	488393	CHEMBL511749	488393		9	446.5	3.23	142.79	0	CC(C)(C)OC(=O)Nc1ccc(cc1)c2onc(c2)C(=O)NCCCCCCC(=O)NO	13431360	IC50	=	93	nM	7.03			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	977734	CHEMBL2424281	B	Inhibition of HDAC2 (unknown origin) using carboxyfluorescein (FAM)-labeled acetylated peptide as substrate after 17 hrs by fluorescence-based electrophoretic assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74749	CHEMBL2417402	23627282	J. Med. Chem.	2013	56	16	6297			
CHEMBL2431901	1583962	CHEMBL2431901	1583962		5a	299.32	1.51	74.57	0	Cn1cccc1C(=O)N2CCc3cc(ccc3C2)C(=O)NO	13467575	IC50	>	50000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	984990	CHEMBL2433164	B	Inhibition of full length C-terminal His6x-tagged recombinant human HDAC2 expressed in baculovirus using Arg-His-Lys-Lys (Ac) as substrate after 1 hr by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75006	CHEMBL2429834	23964961	J. Med. Chem.	2013	56	18	7201			
CHEMBL2442695	1589222	CHEMBL2442695	1589222		33	709.78	5.69	159.83	3	COc1cc(cc(OC)c1O)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](Nc4cccc(OCCCCCCC(=O)Nc5ccccc5N)c4)c6cc7OCOc7cc26	13502673	IC50	=	53520	nM	4.27			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	989630	CHEMBL2445174	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	75370	CHEMBL2439983	24095018	Bioorg. Med. Chem.	2013	21	22	6981			
CHEMBL2436595	1585746	CHEMBL2436595	1585746		11	480.6	1.69	186.99	0	CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c3coc(CNC(=O)C[C@H](OC1=O)\C=C\CCS)n3	13472700	IC50	=	20	nM	7.7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	988355	CHEMBL2437618	B	Inhibition of HDAC2 (unknown origin) using MAZ1600 and MAZ1675 as substrate assessed as fluorogenic release of 7-amino-4-methylcoumarin from substrate by optimized homogenous assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	75140	CHEMBL2434914	24035339	Bioorg. Med. Chem. Lett.	2013	23	21	6025			
CHEMBL3098693	1609464	CHEMBL3098693	1609464		13	390.43	.39	136.63	0	ONC(=O)CCCCC[C@H](NC(=O)C1CCNC1=O)C(=O)Nc2ccccc2	13867808	IC50	=	238	nM	6.62			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	1, SAHA, Vorinostat	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	14660283	IC50	=	410	nM	6.39			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1349595	CHEMBL3265664	B	Inhibition of HDAC2 (unknown origin) using RHKK(Ac) (379 to 382) p53 peptide as substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	83197	CHEMBL3259569	24766560	J. Med. Chem.	2014	57	10	4009			
CHEMBL3417292	1840501	CHEMBL3417292	1840501		11d	663.78	5.55	149.38	2	COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NCc4cccc(c4)C(=O)Nc5cc(ccc5N)c6cccs6	15218903	IC50	=	5410	nM	5.27			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1471124	CHEMBL3421014	B	Inhibition of recombinant human HDAC2 expressed in baculovirus infected insect High5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91571	CHEMBL3414494	25805446	Eur. J. Med. Chem.	2015	95		127			
CHEMBL3421738	1841174	CHEMBL3421738	1841174		10b	413.47	3.06	106.07	0	Cc1ccc(cc1)c2noc(CNCc3ccc(cc3)C(=O)Nc4ccccc4N)n2	15234967	IC50	=	560	nM	6.25			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL3421753	1841189	CHEMBL3421753	1841189		11g	342.32	1.76	100.28	0	ONC(=O)c1ccc(CNCc2onc(n2)c3ccc(F)cc3)cc1	15234982	IC50	=	7690	nM	5.11			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL2018302	1336035	CHEMBL2018302	1336035	TUBASTATIN A	Tubastatin A	335.4	3.08	57.5	0	CN1CCc2c(C1)c3ccccc3n2Cc4ccc(cc4)C(=O)NO	14992237	IC50	>	30000	nM				1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1431996	CHEMBL3388101	B	Inhibition of full length C-terminal 6x-His tagged human HDAC2 using Arg-His-Lys-Lys(Ac) substrate incubated for 2 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			89845	CHEMBL3351349	25454270	Bioorg. Med. Chem. Lett.	2014	24	23	5450			
CHEMBL3356930	1821073	CHEMBL3356930	1821073		19, ST7784	229.38	3.01	67.9	0	SCCCCCCC(=O)NC1CCCC1	15138285	IC50	=	6640	nM	5.18			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3309286	1778374	CHEMBL3309286	1778374		29	375.46	1.95	98.73	0	CN1C(=O)CC(C)(C)c2cc(ccc12)C(=O)NCCCCCCC(=O)NO	15053559	IC50	=	100	nM	7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1450057	CHEMBL3373319	B	Inhibition of human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90190	CHEMBL3351757	24864038	Bioorg. Med. Chem.	2014	22	14	3720			
CHEMBL1478023	901907	CHEMBL1478023	901907		34	254.24	2.65	66.76	0	Oc1ccc(\C=C\2/Oc3ccccc3C2=O)cc1O	14973540	IC50	=	5100	nM	5.29			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1434457	CHEMBL3388274	B	Inhibition of HDAC2 (unknown origin) after 15 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89860	CHEMBL3352210	25455492	Bioorg. Med. Chem. Lett.	2014	24	23	5497			
CHEMBL3427747	1845143	CHEMBL3427747	1845143		3d	275.73	3.25	71.77	0	NC(=O)C1CCCc2c1[nH]nc2c3ccccc3Cl	15255898	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL248787	416389	CHEMBL248787	416389		7e	438.44	4.15	87.66	0	ONC(=O)CCCCCC(OCc1ccc(cc1)C(F)(F)F)C(=O)Nc2ccccc2	2049531	IC50	>=	50	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL249412	416494	CHEMBL249412	416494		4a	266.29	.76	98.66	0	ONC(=O)CCCCC(O)C(=O)Nc1ccccc1	2049598	Activity					Not Active		0	BAO_0000375			458150	CHEMBL925483	B	Inhibition of HDAC2 in HeLa cell lysates at 0.1 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL186311	310810	CHEMBL186311	310810	VALPROPYLHYDROXAMIC ACID	6	159.23	2.13	49.33	0	CCCC(CCC)C(=O)NO	5207896	IC50	=	680000	nM			Outside typical range	0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	718469	CHEMBL1680133	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	55650	CHEMBL1671826	21874153	ACS Med. Chem. Lett.	2011	2	1	39			
CHEMBL483254	499179	CHEMBL483254	499179	PANOBINOSTAT	LBH589	349.43	3.19	77.15	0	Cc1[nH]c2ccccc2c1CCNCc3ccc(\C=C\C(=O)NO)cc3	15470319	IC50	=	13	nM	7.89			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1484269	CHEMBL3538485	B	Inhibition of flag-tagged HDAC2 (unknown origin) expressed in SF21 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation counting	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91925	CHEMBL3526051	22344701	Drug Metab. Dispos.	2012	40	5	1041			
CHEMBL3354920	1819043	CHEMBL3354920	1819043		7o	485.53	4.36	112.68	0	COc1ccccc1C(=O)N[C@H](COc2cccc(\C=C\C(=O)NO)c2)Cc3c[nH]c4ccccc34	14977310	IC50	=	64.8	nM	7.19			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1444505	CHEMBL3374205	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89924	CHEMBL3351443	25462271	Eur. J. Med. Chem.	2015	89		628			
CHEMBL2047615	1351039	CHEMBL2047615	1351039		7c	523.22	6.75	46.92	2	Brc1ccc(NC(=O)\C=C/c2cn(nc2c3ccc(Br)cc3)c4ccccc4)cc1	10947982	IC50	=	4870	nM	5.31			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	827843	CHEMBL2051252	B	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62524	CHEMBL2046430	22705022	Bioorg. Med. Chem.	2012	20	14	4430			
CHEMBL3427767	1845163	CHEMBL3427767	1845163		3w	297.37	3.44	100.01	0	NC(=O)C1CCCc2c1[nH]nc2c3csc4ccccc34	15255994	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL253868	423415	CHEMBL253868	423415		2a	452.5	3.59	106.33	0	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2)c4ccccc4	2073924	IC50	=	72	nM	7.14			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	461756	CHEMBL927762	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38240	CHEMBL1140803	18060775	Bioorg. Med. Chem. Lett.	2008	18	2	726			
CHEMBL1083086	632444	CHEMBL1083086	632444		5g	372.21	1.91	107.53	0	ONC(=O)CCCCCNC(=O)NC(=O)c1ccc(Br)cc1	3311480	Ki	=	12	nM	7.92			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	633817	CHEMBL1119895	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51319	CHEMBL1155491	20451378	Bioorg. Med. Chem. Lett.	2010	20	11	3314			
CHEMBL279636	18643	CHEMBL279636	18643		HC-Toxin	436.5	-.65	137.2	0	C[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCCCC(=O)[C@@H]3CO3)NC(=O)[C@@H](C)NC1=O	3389943	Ki	=	470	nM	6.33			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL2323288	1517445	CHEMBL2323288	1517445		9	479.58	.55	208.02	0	CC(C)[C@@H]1NC(=O)Cn2nnnc2c3csc(CNC(=O)C[C@H](OC1=O)\C=C\CCS)n3	12659625	IC50	=	3270	nM	5.49			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	938235	CHEMBL2328538	B	Inhibition of C-terminal His-tagged full length human recombinant HDAC2 expressed in baculovirus expression system using fluorogenic acetylated peptide as substrate preincubated with enzyme for 10 mins prior to substrate addition measured after 60 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72033	CHEMBL2321647		ACS Med. Chem. Lett.	2013	4	1	132			
CHEMBL2425952	1581071	CHEMBL2425952	1581071		5c	427.49	4.6	82	0	CCC1=Nc2c(Cc3ccc(cc3)C(=O)NO)cccc2C(=O)N1CCc4ccccc4	13451909	IC50	>	10000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL2425959	1581078	CHEMBL2425959	1581078		3g	388.42	2.72	97.79	0	CC1=Nc2cc(\C=C\C(=O)NO)ccc2C(=O)N1CCc3c[nH]c4ccccc34	13451922	IC50	=	2210	nM	5.66			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL3311464	1780574	CHEMBL3311464	1780574		12	331.37	1.43	107.53	0	ONC(=O)CCCCCCC(=O)Nc1ccc2NC(=O)C=Cc2c1	15053552	IC50	=	45	nM	7.35			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1450057	CHEMBL3373319	B	Inhibition of human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90190	CHEMBL3351757	24864038	Bioorg. Med. Chem.	2014	22	14	3720			
CHEMBL449493	461329	CHEMBL449493	461329		(S)-20					OB(O)CCCCC[C@H](NC(=O)c1cccnc1)C(=O)Nc2cccc(c2)c3ccccc3	2513637	IC50	=	830	nM	6.08			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	498746	CHEMBL1021938	B	Inhibition of human recombinant HDAC2 by fluorimetry	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47121	CHEMBL1138526	19419205	J. Med. Chem.	2009	52	9	2909			
CHEMBL326433	184787	CHEMBL326433	184787	8-MERCAPTO-OCTANOIC ACID PHENYLAMIDE	147, ST7775	251.39	3.64	67.9	0	SCCCCCCCC(=O)Nc1ccccc1	15138245	IC50	=	754	nM	6.12			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL1097063	626351	CHEMBL1097063	626351		19	328.36	3.98	68.26	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3oc4ccccc4c3	3286375	IC50	=	10000	nM	5			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1097063	626351	CHEMBL1097063	626351		19	328.36	3.98	68.26	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3oc4ccccc4c3	3286395	IC50	=	10000	nM	5			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL2407733	1572139	CHEMBL2407733	1572139		19b	452.51	3.06	124.4	0	Nc1ccccc1NC(=O)c2ccc(CNC3=NC(=O)C(Cc4c[nH]c5ccccc45)N3)cc2	13395015	IC50	=	78	nM	7.11			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL3235911	1734439	CHEMBL3235911	1734439		2155-14	733.94	6.29	113.5	2	Oc1ccc(C[C@H]2CN([C@H](CC3CCCCC3)CN4CCC[C@H]4CN5[C@@H](Cc6ccccc6)CNC(=O)C5=O)C(=O)C(=O)N2CCc7ccccc7)cc1	14586326	Inhibition					Not Active		0	BAO_0000376			1335770	CHEMBL3239800	B	Inhibition of HDAC2 (unknown origin) up to 100 uM	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			82365	CHEMBL3232843	24471466	J. Med. Chem.	2014	57	4	1599			
CHEMBL2407743	1572149	CHEMBL2407743	1572149		8e	412.44	2.56	126.05	0	Nc1cc(O)ccc1NC(=O)c2ccc(CNc3nccc(n3)c4cccnc4)cc2	13395023	IC50	=	1430	nM	5.84			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL2408778	1573194	CHEMBL2408778	1573194		chimera 4	517.97	4.42	149.66	1	Nc1ncnc2c1c(nn2c3cccc(c3)c4cnnn4CCCCCC(=O)NO)c5ccc(Cl)cc5	13395522	IC50	=	231	nM	6.64			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	972661	CHEMBL2410764	B	Inhibition of HDAC2 (unknown origin) using fluorogenic peptide from p53 residues (379 to 382) (RHKK(Ac)) as substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74303	CHEMBL2406958		ACS Med. Chem. Lett.	2013	4	8	779			
CHEMBL3356924	1821067	CHEMBL3356924	1821067		88, ST8082	391.53	2.28	117.31	0	CN1[C@H](CCC1=O)C(=O)N[C@@H](CCCCCS)C(=O)Nc2cccc(C)c2	15138231	IC50	=	5	nM	8.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL235411	399330	CHEMBL235411	399330		16	378.42	3.73	79.82	0	COc1ccc(NCc2ccc(cc2)C(=O)Nc3ccccc3O)cc1OC	1998266	IC50	=	200	nM	6.7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL235411	399330	CHEMBL235411	399330		16	378.42	3.73	79.82	0	COc1ccc(NCc2ccc(cc2)C(=O)Nc3ccccc3O)cc1OC	1998348	Inhibition	<	50	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	451049	CHEMBL900130	B	Inhibition of human recombinant HDAC2 at 20 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL483893	508341	CHEMBL483893	508341		10d	530.41	3.96	129.37	1	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)c2cn(CC(O)c3cccc(Br)c3)nn2	2351862	IC50	=	64.4	nM	7.19			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL248796	416392	CHEMBL248796	416392		7g	384.47	3.7	87.66	0	Cc1ccc(COC(CCCCCC(=O)NO)C(=O)Nc2ccccc2)cc1	2049529	IC50	>=	50	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL137875	231687	CHEMBL137875	231687		TWZ 108	328.41	3.25	69.64	0	ON(CCCCCCCC(=O)Nc1cccc2ccccc12)C=O	1281845	IC50	=	5900	nM	5.23			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	87875	CHEMBL697297	B	Inhibition of Histone deacetylase 2 (HDAC2) activity of HeLa nuclear extracts	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	6553	CHEMBL1137945	14698179	Bioorg. Med. Chem. Lett.	2004	14	2	449			
CHEMBL251406	416379	CHEMBL251406	416379		4e	308.37	2.04	87.66	0	CCCOC(CCCCC(=O)NO)C(=O)Nc1ccccc1	2049524	IC50	=	500	nM	6.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL271741	435638	CHEMBL271741	435638		54	288.34	3.39	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccccc3	2099198	IC50	=	780	nM	6.11			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	468835	CHEMBL947922	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38804	CHEMBL1143185	18182289	Bioorg. Med. Chem. Lett.	2008	18	3	973			
CHEMBL481538	474722	CHEMBL481538	474722		7g	403.43	3.2	101.9	0	ONC(=O)c1ccc(CN2[C@H](Cc3ccc(O)cc3)C(=O)Nc4ccccc24)cc1	2489480	IC50	=	330	nM	6.48			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	515266	CHEMBL991290	B	Inhibition of human recombinant histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45582	CHEMBL1143301	19111466	Bioorg. Med. Chem. Lett.	2009	19	3	688			
CHEMBL519746	508419	CHEMBL519746	508419		12a	421.49	3.58	109.14	0	ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)c2cnnn2Cc3ccccc3	2351861	IC50	=	124	nM	6.91			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL538710	554210	CHEMBL538710	554210		3d	264.28	2.71	73.12	0	ONC(=O)\C=C\c1ccc(cc1)c2ccc(cc2)C#N	2657750	IC50	=	330	nM	6.48			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL1088734	614517	CHEMBL1088734	614517		4d	475.46	4.65	109.14	0	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)c2cn(nn2)c3ccc(cc3)C(F)(F)F	3201397	IC50	=	28.5	nM	7.55			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	616013	CHEMBL1101057	B	Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			50398	CHEMBL1154884	20055418	J. Med. Chem.	2010	53	3	1347			
CHEMBL2047613	1351037	CHEMBL2047613	1351037		7a	444.32	6	46.92	1	Brc1ccc(cc1)c2nn(cc2\C=C/C(=O)Nc3ccccc3)c4ccccc4	10947980	IC50	=	6520	nM	5.19			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	827843	CHEMBL2051252	B	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62524	CHEMBL2046430	22705022	Bioorg. Med. Chem.	2012	20	14	4430			
CHEMBL235842	399341	CHEMBL235842	399341		60	351.42	2.46	112.46	0	CC(=O)Nc1ccc(cc1)C(=O)Nc2cc(ccc2N)c3cccs3	13297577	IC50	<	300	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	958899	CHEMBL2384807	B	Inhibition of HDAC2 (unknown origin) after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			73668	CHEMBL2380312	23672185	J. Med. Chem.	2013	56	11	4816			
CHEMBL2381518	1560928	CHEMBL2381518	1560928		4	285.3	.81	91.32	0	ONC(=O)c1cccc(c1)C(=O)NCCc2cccnc2	13297587	IC50	=	20000	nM	4.7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	958899	CHEMBL2384807	B	Inhibition of HDAC2 (unknown origin) after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	73668	CHEMBL2380312	23672185	J. Med. Chem.	2013	56	11	4816			
CHEMBL2407736	1572142	CHEMBL2407736	1572142		19c	399.45	2.44	108.61	0	Nc1ccccc1NC(=O)c2ccc(CNC3=NC(=O)C(N3)c4ccccc4)cc2	13395012	IC50	=	56	nM	7.25			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL2407727	1572133	CHEMBL2407727	1572133		8g	426.47	2.19	126.05	0	Nc1cc(CO)ccc1NC(=O)c2ccc(CNc3nccc(n3)c4cccnc4)cc2	13395021	IC50	>	20000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL3098690	1609461	CHEMBL3098690	1609461		10	390.43	.4	136.63	0	ONC(=O)CCCCC[C@H](NC(=O)[C@H]1CCC(=O)N1)C(=O)Nc2ccccc2	13867811	IC50	=	142	nM	6.85			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL2177588	1438374	CHEMBL2177588	1438374		65	474.98	3.78	87.46	0	CN1C[C@H]([C@@H](C1)c2ccc(\C=C\C(=O)Nc3ccccc3N)cc2)C(=O)Nc4ccc(Cl)cc4	12136056	IC50	=	270	nM	6.57			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	874014	CHEMBL2186139	B	Inhibition of HDAC2 using p53 (379 to 382 residues) based fluorogenic peptide substrate	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			66641	CHEMBL2177000	23061376	J. Med. Chem.	2012	55	20	8903			
CHEMBL402727	425562	CHEMBL402727	425562	AZUMAMIDE B	6, azuB	529.63	.94	179.71	2	CC(C)[C@H]1NC(=O)[C@@H](C)[C@@H](C\C=C/CCC(=O)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)NC1=O	13431794	Ki	=	3000	nM	5.52			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	979441	CHEMBL2423477	B	Inhibition of recombinant human HDAC2 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74596	CHEMBL2417416	23865683	J. Med. Chem.	2013	56	16	6512			
CHEMBL2390996	1564563	CHEMBL2390996	1564563		3	406.47	2.84	78.87	0	ONC(=O)\C=C\c1ccc2OC3(CCN(CCc4ccccc4)CC3)CC(=O)c2c1	13337950	IC50	=	190	nM	6.72			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	964225	CHEMBL2395195	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	73929	CHEMBL2390828	23644210	Eur. J. Med. Chem.	2013	64		273			
CHEMBL490018	499906	CHEMBL490018	499906		21	316.39	2.77	78.43	0	C\C(=C/C(=O)NCCCCCC(=O)NO)\C=C\c1ccccc1	2306398	IC50	=	3.1	nM	8.51			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	521104	CHEMBL960365	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46897	CHEMBL1137690	18672316	Eur. J. Med. Chem.	2009	44	3	1067			
CHEMBL1800251	1161314	CHEMBL1800251	1161314		17	331.39	2.28	108.69	0	CN(C(=O)C)c1ccc(cc1)C(=O)CSc2nc(C)cc(O)n2	6283040	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL235413	399333	CHEMBL235413	399333		17	460.54	5.2	108.06	1	COc1ccc(NCc2ccc(cc2)C(=O)Nc3cc(ccc3O)c4cccs4)cc1OC	1998265	IC50	=	60	nM	7.22			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL251011	416384	CHEMBL251011	416384		7d	400.47	3.19	96.89	0	COc1ccc(COC(CCCCCC(=O)NO)C(=O)Nc2ccccc2)cc1	2049534	IC50	>=	50	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL236902	399050	CHEMBL236902	399050		7i	445.51	3.24	100.79	0	C[C@H]1CN(CCN1C(=O)OCc2ccccc2)c3ccc(cn3)C(=O)Nc4ccccc4N	1983085	IC50	=	272	nM	6.57			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	449160	CHEMBL899425	B	Inhibition of recombinant HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			36978	CHEMBL1137437	17761416	Bioorg. Med. Chem. Lett.	2007	17	19	5300			
CHEMBL236902	399050	CHEMBL236902	399050		1	445.51	3.24	100.79	0	C[C@H]1CN(CCN1C(=O)OCc2ccccc2)c3ccc(cn3)C(=O)Nc4ccccc4N	2380714	IC50	=	308	nM	6.51			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	493107	CHEMBL940370	B	Inhibition of human HDAC2 expressed in mammalian cells	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45872	CHEMBL1152282	18951790	Bioorg. Med. Chem. Lett.	2008	18	23	6104			
CHEMBL594544	592378	CHEMBL594544	592378		3i2	387.41	1.45	101.82	0	OCC(\C=C\c1ccc(F)cc1)N2CCN(CC2)c3ncc(cn3)C(=O)NO	3079147	IC50	=	17.9	nM	7.75			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	605911	CHEMBL1068528	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	49395	CHEMBL1153112	19906529	Bioorg. Med. Chem. Lett.	2010	20	1	294			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	1, TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	5090664	IC50	=	22.95	nM	7.64			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	690171	CHEMBL1634301	B	Inhibition of human HDAC2 by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	54338	CHEMBL1629537	21073160	J. Med. Chem.	2010	53	23	8387			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	2, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	5090665	IC50	=	921	nM	6.04			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	690171	CHEMBL1634301	B	Inhibition of human HDAC2 by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	54338	CHEMBL1629537	21073160	J. Med. Chem.	2010	53	23	8387			
CHEMBL251011	416384	CHEMBL251011	416384		(R/S)-7	400.47	3.19	96.89	0	COc1ccc(COC(CCCCCC(=O)NO)C(=O)Nc2ccccc2)cc1	5090667	IC50	=	254	nM	6.6			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	690171	CHEMBL1634301	B	Inhibition of human HDAC2 by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	54338	CHEMBL1629537	21073160	J. Med. Chem.	2010	53	23	8387			
CHEMBL1631912	1054904	CHEMBL1631912	1054904		(R/S)-8c	392.49	3.44	96.89	0	ONC(=O)CCCCCC1OCCCCCCCOc2ccccc2NC1=O	5090670	IC50	=	1540	nM	5.81			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	690171	CHEMBL1634301	B	Inhibition of human HDAC2 by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	54338	CHEMBL1629537	21073160	J. Med. Chem.	2010	53	23	8387			
CHEMBL1631916	1054908	CHEMBL1631916	1054908		(R/S)-10	456.53	3.71	106.11	0	COc1cc2CCCOC(CCCCCC(=O)NO)C(=O)Nc3ccccc3OCc(c2)c1	5090674	IC50	=	793	nM	6.1			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	690171	CHEMBL1634301	B	Inhibition of human HDAC2 by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	54338	CHEMBL1629537	21073160	J. Med. Chem.	2010	53	23	8387			
CHEMBL1631918	1054910	CHEMBL1631918	1054910		(R)-10	456.53	3.71	106.11	0	COc1cc2CCCO[C@H](CCCCCC(=O)NO)C(=O)Nc3ccccc3OCc(c2)c1	5090676	IC50	=	425	nM	6.37			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	690171	CHEMBL1634301	B	Inhibition of human HDAC2 by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	54338	CHEMBL1629537	21073160	J. Med. Chem.	2010	53	23	8387			
CHEMBL2063396	1356793	CHEMBL2063396	1356793		26	540.7	2.71	124.56	1	CCC[C@@H]1NC(=O)[C@H](C)NC(=O)C[C@H](CC(C)C)NC(=O)[C@H](Cc2cn(CN(C)C)c3ccccc23)NC1=O	10981390	Ratio IC50	=	40					0	BAO_0000179			831132	CHEMBL2065945	B	Ratio of IC50 for valproic acid to compound for recombinant HDAC2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			62769	CHEMBL2062402		ACS Med. Chem. Lett.	2012	3	6	505			
CHEMBL2063396	1356793	CHEMBL2063396	1356793		26	540.7	2.71	124.56	1	CCC[C@@H]1NC(=O)[C@H](C)NC(=O)C[C@H](CC(C)C)NC(=O)[C@H](Cc2cn(CN(C)C)c3ccccc23)NC1=O	10981403	IC50	=	1400	nM	5.85			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	831128	CHEMBL2065941	B	Inhibition of recombinant HDAC2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			62769	CHEMBL2062402		ACS Med. Chem. Lett.	2012	3	6	505			
CHEMBL2063395	1356792	CHEMBL2063395	1356792		15	483.6	2.38	132.18	0	CCC[C@@H]1NC(=O)[C@H](C)NC(=O)C[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10981404	IC50	=	1500	nM	5.82			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	831128	CHEMBL2065941	B	Inhibition of recombinant HDAC2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			62769	CHEMBL2062402		ACS Med. Chem. Lett.	2012	3	6	505			
CHEMBL2063396	1356793	CHEMBL2063396	1356793		26	540.7	2.71	124.56	1	CCC[C@@H]1NC(=O)[C@H](C)NC(=O)C[C@H](CC(C)C)NC(=O)[C@H](Cc2cn(CN(C)C)c3ccccc23)NC1=O	10981416	Ki	=	33	nM	7.48			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	831143	CHEMBL2065956	B	Competitive inhibition of HDAC2 using Ac-Lys(Ac)-AMC as substrate by Lineweaver-Burk plot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			62769	CHEMBL2062402		ACS Med. Chem. Lett.	2012	3	6	505			
CHEMBL2022826	1338198	CHEMBL2022826	1338198		4	585.78	8.07	130.92	2	O=C(N[C@@H](CCCCCCSSc1ccccn1)C(=O)Nc2ccccc2c3ccccc3)OCc4ccccc4	10862527	IC50	=	45.2	nM	7.34			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	816365	CHEMBL2024763	B	Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	61731	CHEMBL2021837	22465091	Eur. J. Med. Chem.	2012	52		111			
CHEMBL2021937	1338200	CHEMBL2021937	1338200		6	600.79	8.73	128.12	2	O=C(N[C@@H](CCCCCCSSc1ccccn1)C(=O)OCc2ccc(cc2)c3ccccc3)OCc4ccccc4	10862533	IC50	=	40.7	nM	7.39			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	816365	CHEMBL2024763	B	Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	61731	CHEMBL2021837	22465091	Eur. J. Med. Chem.	2012	52		111			
CHEMBL2022830	1338203	CHEMBL2022830	1338203		9	569.69	7.1	173.94	2	[O-][N+](=O)c1ccc(COC(=O)[C@H](CCCCCCSSc2ccccn2)NC(=O)OCc3ccccc3)cc1	10862542	IC50	=	45.5	nM	7.34			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	816365	CHEMBL2024763	B	Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	61731	CHEMBL2021837	22465091	Eur. J. Med. Chem.	2012	52		111			
CHEMBL2047609	1351033	CHEMBL2047609	1351033		6a	395.45	5.24	56.15	1	COc1ccc(cc1)c2nn(cc2\C=C/C(=O)Nc3ccccc3)c4ccccc4	10947976	IC50	=	2670	nM	5.57			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	827843	CHEMBL2051252	B	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62524	CHEMBL2046430	22705022	Bioorg. Med. Chem.	2012	20	14	4430			
CHEMBL2047611	1351035	CHEMBL2047611	1351035		6c	474.35	5.99	56.15	1	COc1ccc(cc1)c2nn(cc2\C=C/C(=O)Nc3ccc(Br)cc3)c4ccccc4	10947978	IC50	=	2170	nM	5.66			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	827843	CHEMBL2051252	B	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62524	CHEMBL2046430	22705022	Bioorg. Med. Chem.	2012	20	14	4430			
CHEMBL27759	36237	CHEMBL27759	36237	ENTINOSTAT	MS-275	376.41	2.07	106.33	0	Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2	10947988	IC50	<	100	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	827843	CHEMBL2051252	B	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62524	CHEMBL2046430	22705022	Bioorg. Med. Chem.	2012	20	14	4430			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	1, TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	6314698	IC50	=	4	nM	8.4			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	761695	CHEMBL1816687	B	Inhibition of human HDAC2 using rhodamine as substrate after 1 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	58554	CHEMBL1811912	21723733	Bioorg. Med. Chem.	2011	19	15	4626			
CHEMBL3233696	1732202	CHEMBL3233696	1732202		11p	469.53	4.41	103.45	0	ONC(=O)\C=C\c1ccc(OC[C@H](Cc2c[nH]c3ccccc23)NC(=O)Cc4ccccc4)cc1	14573363	Inhibition					Active		0	BAO_0000376			1337867	CHEMBL3240894	B	Inhibition of HDAC2 in human U937 cells assessed as increase of intracellular acetylated histone H3 level at 1 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			82316	CHEMBL3232921	24694055	J. Med. Chem.	2014	57	8	3324			
CHEMBL3233703	1732209	CHEMBL3233703	1732209		11w	473.5	4.59	103.45	0	ONC(=O)\C=C\c1ccc(OC[C@H](Cc2c[nH]c3ccccc23)NC(=O)c4ccc(F)cc4)cc1	14573365	Inhibition					Active		0	BAO_0000376			1337867	CHEMBL3240894	B	Inhibition of HDAC2 in human U937 cells assessed as increase of intracellular acetylated histone H3 level at 1 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			82316	CHEMBL3232921	24694055	J. Med. Chem.	2014	57	8	3324			
CHEMBL3233705	1732211	CHEMBL3233705	1732211		11y	485.53	4.36	112.68	0	COc1ccc(cc1)C(=O)N[C@H](COc2ccc(\C=C\C(=O)NO)cc2)Cc3c[nH]c4ccccc34	14573366	Inhibition					Active		0	BAO_0000376			1337867	CHEMBL3240894	B	Inhibition of HDAC2 in human U937 cells assessed as increase of intracellular acetylated histone H3 level at 1 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			82316	CHEMBL3232921	24694055	J. Med. Chem.	2014	57	8	3324			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SA, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	14573367	Inhibition					Active		0	BAO_0000376			1337867	CHEMBL3240894	B	Inhibition of HDAC2 in human U937 cells assessed as increase of intracellular acetylated histone H3 level at 1 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			82316	CHEMBL3232921	24694055	J. Med. Chem.	2014	57	8	3324			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	14586626	IC50	=	921	nM	6.04			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1335359	CHEMBL3238938	B	Inhibition of human HDAC-2 using RHKK(Ac) as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82391	CHEMBL3232879	24565573	Eur. J. Med. Chem.	2014	76		53			
CHEMBL3235912	1734440	CHEMBL3235912	1734440		2155-18	786.01	6.51	113.5	2	Oc1ccc(C[C@H]2CN([C@H](CN3CCC[C@H]3CN4[C@@H](Cc5ccccc5)CNC(=O)C4=O)Cc6ccccc6)C(=O)C(=O)N2CCC78CC9CC(CC(C9)C7)C8)cc1	14586325	Inhibition					Not Active		0	BAO_0000376			1335770	CHEMBL3239800	B	Inhibition of HDAC2 (unknown origin) up to 100 uM	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			82365	CHEMBL3232843	24471466	J. Med. Chem.	2014	57	4	1599			
CHEMBL3235118	1733638	CHEMBL3235118	1733638		43	580.68	4.31	162.07	1	CC(C)c1cc(c(O)cc1O)n2nnc(C(=O)NCCCCCCC(=O)NO)c2c3ccc(CN4CCOCC4)cc3	14574602	IC50	=	5610	nM	5.25			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1338815	CHEMBL3242742	B	Inhibition of human HDAC-2 using RHKK(Ac) as substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82411	CHEMBL3232837	24588105	J. Med. Chem.	2014	57	6	2258			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA, vorinostat	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	14574603	IC50	=	920	nM	6.04			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1338815	CHEMBL3242742	B	Inhibition of human HDAC-2 using RHKK(Ac) as substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82411	CHEMBL3232837	24588105	J. Med. Chem.	2014	57	6	2258			
CHEMBL1957463	1282994	CHEMBL1957463	1282994		1a	501.6	4.23	125.29	1	Nc1ccc(cc1NC(=O)c2ccc(CN(CCO)Cc3ccc4OCOc4c3)cc2)c5cccs5	8048584	IC50	=	740	nM	6.13			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	807676	CHEMBL1959441	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			61262	CHEMBL1955769	22321215	Bioorg. Med. Chem. Lett.	2012	22	5	1926			
CHEMBL107	14440	CHEMBL107	14440	COLCHICINE	Colchicine	399.44	2.04	83.09	0	COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(=O)C	15218935	IC50	>	20	ug.mL-1				0	BAO_0000190	UO_0000274	http://www.openphacts.org/units/MicrogramPerMilliliter	1471124	CHEMBL3421014	B	Inhibition of recombinant human HDAC2 expressed in baculovirus infected insect High5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91571	CHEMBL3414494	25805446	Eur. J. Med. Chem.	2015	95		127			
CHEMBL3335299	1791432	CHEMBL3335299	1791432		21	364.44	4.04	79.18	0	ONC(=O)CCCCc1ccn(Cc2ccc(Nc3ccccc3)cc2)n1	15086178	IC50	=	204	nM	6.69			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1433878	CHEMBL3388839	B	Inhibition of human recombinant HDAC2 after 60 mins by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89339	CHEMBL3352093	25218912	Eur. J. Med. Chem.	2014	86		639			
CHEMBL3338404	1792904	CHEMBL3338404	1792904		12	393.39	3.46	111.53	0	ONC(=O)c1ccc2CCN(Cc3oc(cc3)c4cccc(c4)[N+](=O)[O-])Cc2c1	15077078	IC50	=	109000	nM			Outside typical range	0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1433099	CHEMBL3386356	B	Inhibition of HDAC2 (unknown origin) using fluorogenic peptide as substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89385	CHEMBL3351740	25238284	J. Med. Chem.	2014	57	19	8026			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	6, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	15249664	IC50	=	120.5	nM	6.92			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1476047	CHEMBL3428543	B	Inhibition of full length human recombinant HDAC2 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Ac)-AMC as substrate after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91812	CHEMBL3425494	25906087	J. Med. Chem.	2015	58	10	4325			
CHEMBL3427763	1845159	CHEMBL3427763	1845159		3s	280.32	3.17	87.56	0	NC(=O)C1CCCc2c1[nH]nc2c3cc4ccccc4[nH]3	15255969	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL3427772	1845168	CHEMBL3427772	1845168		13c	348.24	3.79	71.77	0	CC1(C)CC(C(=O)N)c2[nH]nc(c2C1)c3ccc(Br)cc3	15255999	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL3394306	1828121	CHEMBL3394306	1828121		53	333.38	3.1	120.08	0	ONC(=O)c1sc2ccccc2c1S(=O)(=O)c3ccccc3	15151767	Inhibition					Not Active		0	BAO_0000376			1461368	CHEMBL3396299	B	Inhibition of full length C-terminal His-tagged human HDAC2 expressed in baculovirus expression system assessed as inhibition of fluorophore 7-amino-4-methylcoumarin release by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			90878	CHEMBL3392986	25490700	J. Med. Chem.	2015	58	2	785			
CHEMBL3421754	1841190	CHEMBL3421754	1841190		11h	330.36	1.5	128.52	0	ONC(=O)c1ccc(CNCc2onc(n2)c3cccs3)cc1	15234983	IC50	>	10000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL2425957	1581076	CHEMBL2425957	1581076		3e	335.36	2.1	82	0	CC1=Nc2cc(\C=C\C(=O)NO)ccc2C(=O)N1Cc3ccccc3	13451924	IC50	=	4000	nM	5.4			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	983628	CHEMBL2427283	B	Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74834	CHEMBL2424579	23905680	J. Med. Chem.	2013	56	17	6775			
CHEMBL1767047	1142086	CHEMBL1767047	1142086		43	500.63	5.2	94.02	2	CNC(=O)\C(=N/O)\CCCCC[C@H](N(Cc1ccccc1)Cc2ccccc2)C(=O)Nc3ccccc3	6174083	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL513160	488609	CHEMBL513160	488609		1	290.31	2.01	84.59	0	ONC(=O)CCCCOCc1cc(on1)c2ccccc2	2569551	IC50	=	133	nM	6.88			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	514670	CHEMBL976442	B	Inhibition of HDAC2 after 17 hrs	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			44070	CHEMBL1155917	18642892	J. Med. Chem.	2008	51	15	4370			
CHEMBL1814815	1169862	CHEMBL1814815	1169862		9	557.71	-2.19	232.71	2	CC(=O)NCCC[C@H](NC(=O)[C@H](CCCCNC(=S)C)NC(=O)[C@H](CCCNC(=O)C)NC(=O)C)C(=O)N	14535128	Activity					Not Active		0	BAO_0000375			1328677	CHEMBL3226304	B	Activity of HDAC2 in human HeLa cells nuclear extract assessed as compound deacetylation measured up to 2 hrs by time course assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			81713	CHEMBL3217699		MedChemComm	2010	1	3	233			
CHEMBL3317811	1782450	CHEMBL3317811	1782450		4	560.71	2.72	222.31	1	C[C@@]12CSC(=N1)c3csc(CNC(=O)C[C@H](OC(=O)[C@H](Cc4ccc(O)cc4)NC2=O)\C=C\CCS)n3	15060218	IC50	=	1.1	nM	8.96			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1452234	CHEMBL3366146	B	Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90621	CHEMBL3352389	25070421	Bioorg. Med. Chem. Lett.	2014	24	16	3728			
CHEMBL481802	473680	CHEMBL481802	473680		7a	297.31	1.4	81.67	0	ONC(=O)c1ccc(CN2CC(=O)Nc3ccccc23)cc1	2489474	IC50	=	560	nM	6.25			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	515266	CHEMBL991290	B	Inhibition of human recombinant histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45582	CHEMBL1143301	19111466	Bioorg. Med. Chem. Lett.	2009	19	3	688			
CHEMBL3235462	1733985	CHEMBL3235462	1733985		2a	373.49	5.24	49.33	1	ONC(=O)\C=C\c1ccc(cc1)c2cccc(c2)C34CC5CC(CC(C5)C3)C4	14570882	IC50	>	10000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1335247	CHEMBL3238600	B	Inhibition of HDAC2 in human HeLa cells using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			82343	CHEMBL3232764	24742384	Eur. J. Med. Chem.	2014	79		251			
CHEMBL180064	301114	CHEMBL180064	301114		13	295.4	.75	100.24	0	CN(C)c1ccc(cc1)C(=O)NCCCNC(=O)CS	1902505	IC50	>	30000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	439074	CHEMBL889422	B	Inhibition of His-tagged HDAC2 expressed in Sf9 cells by fluorescence-based assay	1	Scientific Literature				Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			36060	CHEMBL1145385	17539623	J. Med. Chem.	2007	50	13	3054	1759	CHEMBL3308860	Sf9
CHEMBL539156	559450	CHEMBL539156	559450		17	261.32	3.03	69.56	0	ONC(=O)\C=C\C1CCC(CC1)c2ccc(O)cc2	2657747	IC50	=	310	nM	6.51			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL236061	399344	CHEMBL236061	399344		22	242.27	1.85	64.35	0	COc1ccc(cc1)C(=O)Nc2ccccc2N	1998284	IC50	=	900	nM	6.05			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL236061	399344	CHEMBL236061	399344		22	242.27	1.85	64.35	0	COc1ccc(cc1)C(=O)Nc2ccccc2N	1998344	Inhibition	<	50	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	451049	CHEMBL900130	B	Inhibition of human recombinant HDAC2 at 20 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL1097748	626286	CHEMBL1097748	626286		18	367.24	4.13	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccc(Br)cc3	3286440	Ratio IC50	=	40					0	BAO_0000179			630933	CHEMBL1116532	B	Selectivity ratio of IC50 for human recombinant HDAC2 preincubated for 1 hr with substrate to IC50 for human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1097748	626286	CHEMBL1097748	626286		18	367.24	4.13	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccc(Br)cc3	3286376	IC50	=	600	nM	6.22			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1097748	626286	CHEMBL1097748	626286		18	367.24	4.13	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccc(Br)cc3	3286396	IC50	=	24000	nM	4.62			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1800373	1161437	CHEMBL1800373	1161437		18	379.43	3.73	117.47	0	Cc1cc(O)nc(SCC(=O)c2ccc(NC(=O)c3ccccc3)cc2)n1	6283041	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL1796689	1159741	CHEMBL1796689	1159741	LARGAZOLE THIOL	2	496.67	2.25	202.09	0	CC(C)[C@H]1NC(=O)[C@]2(C)CSC(=N2)c3csc(CNC(=O)C[C@H](OC1=O)\C=C\CCS)n3	15060220	IC50	=	.9	nM	9.05			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1452234	CHEMBL3366146	B	Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90621	CHEMBL3352389	25070421	Bioorg. Med. Chem. Lett.	2014	24	16	3728			
CHEMBL235194	399329	CHEMBL235194	399329		15	459.56	4.7	113.85	0	COc1ccc(NCc2ccc(cc2)C(=O)Nc3ccc(cc3N)c4cccs4)cc1OC	1998349	Inhibition	<	50	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	451049	CHEMBL900130	B	Inhibition of human recombinant HDAC2 at 20 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL235194	399329	CHEMBL235194	399329		15	459.56	4.7	113.85	0	COc1ccc(NCc2ccc(cc2)C(=O)Nc3ccc(cc3N)c4cccs4)cc1OC	1998267	IC50	>	10000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL257632	436393	CHEMBL257632	436393		22	420.47	2.04	144.31	0	Nc1ccccc1NC(=O)c2ccc(CNc3nc(N)nc(n3)N4CCOCC4)cc2	2097986	Activity					Active		0	BAO_0000375			468079	CHEMBL931663	B	Activity against HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38730	CHEMBL1143113	18160287	Bioorg. Med. Chem. Lett.	2008	18	3	1067			
CHEMBL437029	435595	CHEMBL437029	435595		56	521.61	4.76	100.79	1	C[C@H]1CN(CCN1C(=O)OCc2ccccc2)c3ccc(cn3)C(=O)Nc4cc(ccc4N)c5ccccc5	2099199	IC50	=	640	nM	6.19			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	468835	CHEMBL947922	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38804	CHEMBL1143185	18182289	Bioorg. Med. Chem. Lett.	2008	18	3	973			
CHEMBL1800383	1161447	CHEMBL1800383	1161447		30	270.3	1.66	114.68	0	CCOC(=O)CC(=O)CSc1nc(C)cc(O)n1	6283053	IC50	=	69300	nM	4.16			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL1914708	1262147	CHEMBL1914708	1262147		3f	440.46	3.63	195.75	0	ONC(=O)CCCCCCC(=O)Nc1cnn(Cc2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c1	7921740	IC50	=	1000	nM	6			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	785884	CHEMBL1921153	B	Inhibition of human recombinant HDAC2 using fluorophore-conjugated substrate Boc-L-Lys(Ac)-AMC after 60 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	60081	CHEMBL1914352	21548582	J. Med. Chem.	2011	54	13	4350			
CHEMBL1914708	1262147	CHEMBL1914708	1262147		3f	440.46	3.63	195.75	0	ONC(=O)CCCCCCC(=O)Nc1cnn(Cc2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c1	7921767	Ratio IC50	=	14.7					0	BAO_0000179			785760	CHEMBL1920780	B	Selectivity ratio of compound IC50 to TSA IC50 for human recombinant HDAC2 using fluorophore-conjugated substrate Boc-L-Lys(Ac)-AMC after 60 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			60081	CHEMBL1914352	21548582	J. Med. Chem.	2011	54	13	4350			
CHEMBL1914708	1262147	CHEMBL1914708	1262147		3f	440.46	3.63	195.75	0	ONC(=O)CCCCCCC(=O)Nc1cnn(Cc2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])c1	7921785	Ratio IC50	=	10					0	BAO_0000179			785751	CHEMBL1920771	B	Selectivity ratio of compound IC50 to SAHA IC50 for human recombinant HDAC2 using fluorophore-conjugated substrate Boc-L-Lys(Ac)-AMC after 60 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			60081	CHEMBL1914352	21548582	J. Med. Chem.	2011	54	13	4350			
CHEMBL402363	426196	CHEMBL402363	426196	AZUMAMIDE E	9, azuE	514.61	1.8	153.69	1	CC(C)[C@H]1NC(=O)[C@@H](C)[C@@H](C\C=C/CCC(=O)O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	13431791	Ki	=	50	nM	7.3			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	979441	CHEMBL2423477	B	Inhibition of recombinant human HDAC2 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74596	CHEMBL2417416	23865683	J. Med. Chem.	2013	56	16	6512			
CHEMBL48310	74170	CHEMBL48310	74170	HINOKITIOL	beta-tj	164.2	1.9	37.29	0	CC(C)C1=CC=CC(=O)C(=C1)O	13393172	Ki	=	15.44	nM	7.81			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	972539	CHEMBL2410191	B	Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74297	CHEMBL2407068		ACS Med. Chem. Lett.	2013	4	8	757			
CHEMBL2408243	1572654	CHEMBL2408243	1572654		7b	228.24	2.2	46.53	0	COc1ccc(cc1)C2=CC(=O)C(=CC=C2)O	13393221	Ki	=	.12	nM	9.92			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	972539	CHEMBL2410191	B	Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74297	CHEMBL2407068		ACS Med. Chem. Lett.	2013	4	8	757			
CHEMBL351806	263399	CHEMBL351806	263399		8, NSA	381.44	3.78	91.85	0	OC(=O)[C@H](Cc1ccccc1)NS(=O)(=O)c2ccc(cc2)c3ccccc3	13488734	Inhibition					Not Active		0	BAO_0000376			987733	CHEMBL2439711	B	Inhibition of HDAC2 (unknown origin)-mediated deacetylation at 10 uM preincubated for 5 mins prior to substrate addition measured after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75182	CHEMBL2434956	24074025	J. Med. Chem.	2013	56	20	7997			
CHEMBL2431862	1583923	CHEMBL2431862	1583923		1	273.29	1.23	83.36	0	Cn1cccc1C(=O)NCc2ccc(cc2)C(=O)NO	14992233	IC50	=	16000	nM	4.8			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1431996	CHEMBL3388101	B	Inhibition of full length C-terminal 6x-His tagged human HDAC2 using Arg-His-Lys-Lys(Ac) substrate incubated for 2 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89845	CHEMBL3351349	25454270	Bioorg. Med. Chem. Lett.	2014	24	23	5450			
CHEMBL3356915	1821058	CHEMBL3356915	1821058		50, ST7540	377.5	2.03	126.1	0	SCCCCC[C@H](NC(=O)[C@H]1CCCNC1=O)C(=O)Nc2ccccc2	15138240	IC50	=	48	nM	7.32			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3352996	1817099	CHEMBL3352996	1817099		9a	500.59	1.34	153.69	1	CC(C)[C@H]1NC(=O)C[C@@H](C\C=C/CCC(=O)O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	15126328	Ki	=	900	nM	6.05			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	1440125	CHEMBL3382538	B	Inhibition of human recombinant HDAC2 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89689	CHEMBL3351463	25380299	J. Med. Chem.	2014	57	22	9644			
CHEMBL3427769	1845165	CHEMBL3427769	1845165		10	303.79	4.16	71.77	0	NC(=O)C1CCCCCc2c1[nH]nc2c3ccc(Cl)cc3	15255996	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL2431862	1583923	CHEMBL2431862	1583923		1a	273.29	1.23	83.36	0	Cn1cccc1C(=O)NCc2ccc(cc2)C(=O)NO	13467511	IC50	=	16000	nM	4.8			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	984990	CHEMBL2433164	B	Inhibition of full length C-terminal His6x-tagged recombinant human HDAC2 expressed in baculovirus using Arg-His-Lys-Lys (Ac) as substrate after 1 hr by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	75006	CHEMBL2429834	23964961	J. Med. Chem.	2013	56	18	7201			
CHEMBL2408248	1572659	CHEMBL2408248	1572659		8	178.23	2.12	26.3	0	COC1=CC=CC(=CC1=O)C(C)C	13392182	Ki	>	2500	nM				0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	972539	CHEMBL2410191	B	Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74297	CHEMBL2407068		ACS Med. Chem. Lett.	2013	4	8	757			
CHEMBL252409	423422	CHEMBL252409	423422		2	451.52	4.74	93.44	0	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3ccccc3)cc2)c4ccccc4	10954398	Ratio IC50	=	2.7					0	BAO_0000179			829156	CHEMBL2059978	B	Ratio of IC50 for human HDAC2 preincubated for 3 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL252409	423422	CHEMBL252409	423422		2	451.52	4.74	93.44	0	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3ccccc3)cc2)c4ccccc4	10954411	Ratio IC50	=	52					0	BAO_0000179			829157	CHEMBL2059979	B	Ratio of IC50 for human HDAC2 preincubated for 24 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL252409	423422	CHEMBL252409	423422		2	451.52	4.74	93.44	0	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3ccccc3)cc2)c4ccccc4	10954448	Inhibition					tde		0	BAO_0000376			829163	CHEMBL2059985	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL252409	423422	CHEMBL252409	423422		2	451.52	4.74	93.44	0	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3ccccc3)cc2)c4ccccc4	10954268	IC50	=	38000	nM	4.42			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829146	CHEMBL2059968	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 5 mins measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL252409	423422	CHEMBL252409	423422		2	451.52	4.74	93.44	0	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3ccccc3)cc2)c4ccccc4	10954281	IC50	=	14000	nM	4.85			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829147	CHEMBL2059969	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 3 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL252409	423422	CHEMBL252409	423422		2	451.52	4.74	93.44	0	Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3ccccc3)cc2)c4ccccc4	10954294	IC50	=	740	nM	6.13			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829148	CHEMBL2059970	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 24 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL1631915	1054907	CHEMBL1631915	1054907		(R)-9	454.52	3.4	106.11	0	COc1cc2COc3ccccc3NC(=O)[C@@H](CCCCCC(=O)NO)OC\C=C/c(c2)c1	5090673	IC50	=	382	nM	6.42			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	690171	CHEMBL1634301	B	Inhibition of human HDAC2 by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	54338	CHEMBL1629537	21073160	J. Med. Chem.	2010	53	23	8387			
CHEMBL3421748	1841184	CHEMBL3421748	1841184		11b	338.36	2.04	100.28	0	Cc1ccc(cc1)c2noc(CNCc3ccc(cc3)C(=O)NO)n2	15234977	IC50	>	10000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL3427773	1845169	CHEMBL3427773	1845169		13d	322.4	3.83	76.69	0	Cn1c(cc2ccccc12)c3n[nH]c4C(CC(C)(C)Cc34)C(=O)N	15256000	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL402719	416383	CHEMBL402719	416383		7c	320.38	2.24	87.66	0	ONC(=O)CCCCCC(OCC=C)C(=O)Nc1ccccc1	2049520	IC50	=	500	nM	6.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL402719	416383	CHEMBL402719	416383		7c	320.38	2.24	87.66	0	ONC(=O)CCCCCC(OCC=C)C(=O)Nc1ccccc1	2049602	Activity					Not Active		0	BAO_0000375			458150	CHEMBL925483	B	Inhibition of HDAC2 in HeLa cell lysates at 0.1 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL1213490	685334	CHEMBL1213490	685334	ROMIDEPSIN	52 FK-228	541.72	2.26	208.27	1	C\C=C\1/NC(=O)[C@@H](CS)NC(=O)[C@H](CC(=O)C[C@H](OC(=O)[C@@H](NC1=O)C(C)C)\C=C\CCS)C(C)C	167391	IC50	=	47	nM	7.33			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	87876	CHEMBL697298	B	Inhibitory concentration against human Histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	17295	CHEMBL1145900	14613312	J. Med. Chem.	2003	46	24	5097			
CHEMBL141082	232358	CHEMBL141082	232358		TWZ 102	250.29	1.43	69.64	0	ON(CCCCCC(=O)Nc1ccccc1)C=O	1275485	IC50	=	19000	nM	4.72			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	87875	CHEMBL697297	B	Inhibition of Histone deacetylase 2 (HDAC2) activity of HeLa nuclear extracts	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	6553	CHEMBL1137945	14698179	Bioorg. Med. Chem. Lett.	2004	14	2	449			
CHEMBL507592	479513	CHEMBL507592	479513		13	295.33	1.61	104.46	0	ONC(=O)c1cc(CCCCC(=O)NC2CCCC2)on1	2641986	IC50	>	30000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	500548	CHEMBL971413	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			46730	CHEMBL1136917	19419863	Bioorg. Med. Chem. Lett.	2009	19	11	3023			
CHEMBL551486	563011	CHEMBL551486	563011		3b	269.3	2.23	69.56	0	OCc1ccc(cc1)c2ccc(\C=C\C(=O)NO)cc2	2657743	IC50	=	220	nM	6.66			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL1096072	626353	CHEMBL1096072	626353		21	356.34	4.33	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccc(cc3)C(F)(F)F	3286442	Ratio IC50	=	10					0	BAO_0000179			630933	CHEMBL1116532	B	Selectivity ratio of IC50 for human recombinant HDAC2 preincubated for 1 hr with substrate to IC50 for human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1091475	614516	CHEMBL1091475	614516		4c	533.36	4.29	109.14	1	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)c2cn(nn2)c3ccc(I)cc3	3201395	IC50	=	24.6	nM	7.61			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	616013	CHEMBL1101057	B	Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			50398	CHEMBL1154884	20055418	J. Med. Chem.	2010	53	3	1347			
CHEMBL1096072	626353	CHEMBL1096072	626353		21	356.34	4.33	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccc(cc3)C(F)(F)F	3286373	IC50	=	3800	nM	5.42			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1096398	626136	CHEMBL1096398	626136		7	344.43	4.54	83.36	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3cc4ccccc4s3	3286387	IC50	=	10000	nM	5			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1096072	626353	CHEMBL1096072	626353		21	356.34	4.33	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccc(cc3)C(F)(F)F	3286393	IC50	=	40000	nM	4.4			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1096398	626136	CHEMBL1096398	626136		7	344.43	4.54	83.36	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3cc4ccccc4s3	3286407	IC50	=	10000	nM	5			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL271741	435638	CHEMBL271741	435638		1	288.34	3.39	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccccc3	10954397	Ratio IC50	=	3.4					0	BAO_0000179			829156	CHEMBL2059978	B	Ratio of IC50 for human HDAC2 preincubated for 3 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL271741	435638	CHEMBL271741	435638		1	288.34	3.39	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccccc3	10954410	Ratio IC50	=	8.6					0	BAO_0000179			829157	CHEMBL2059979	B	Ratio of IC50 for human HDAC2 preincubated for 24 hrs to IC50 for human HDAC2 preincubated for 5 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL271741	435638	CHEMBL271741	435638		1	288.34	3.39	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccccc3	10954447	Inhibition					tde		0	BAO_0000376			829163	CHEMBL2059985	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL271741	435638	CHEMBL271741	435638		1	288.34	3.39	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccccc3	10954267	IC50	=	1200	nM	5.92			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829146	CHEMBL2059968	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 5 mins measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL271741	435638	CHEMBL271741	435638		1	288.34	3.39	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccccc3	10954280	IC50	=	350	nM	6.46			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829147	CHEMBL2059969	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 3 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL271741	435638	CHEMBL271741	435638		1	288.34	3.39	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccccc3	10954293	IC50	=	140	nM	6.85			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	829148	CHEMBL2059970	B	Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 24 hrs measured after 35 mins by spectrofluorometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62629	CHEMBL2057127	22771007	Bioorg. Med. Chem. Lett.	2012	22	15	5025			
CHEMBL3233698	1732204	CHEMBL3233698	1732204		11r	489.95	5.04	103.45	1	ONC(=O)\C=C\c1ccc(OC[C@H](Cc2c[nH]c3ccccc23)NC(=O)c4ccc(Cl)cc4)cc1	14573364	Inhibition					Active		0	BAO_0000376			1337867	CHEMBL3240894	B	Inhibition of HDAC2 in human U937 cells assessed as increase of intracellular acetylated histone H3 level at 1 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			82316	CHEMBL3232921	24694055	J. Med. Chem.	2014	57	8	3324			
CHEMBL3233755	1732261	CHEMBL3233755	1732261		29	488.53	2.51	165.23	0	CC(C)c1cc(C(=O)N2CCc3onc(C(=O)NCCCCCCC(=O)NO)c3C2)c(O)cc1O	14586632	IC50	=	9490	nM	5.02			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1335359	CHEMBL3238938	B	Inhibition of human HDAC-2 using RHKK(Ac) as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82391	CHEMBL3232879	24565573	Eur. J. Med. Chem.	2014	76		53			
CHEMBL3233698	1732204	CHEMBL3233698	1732204		11r	489.95	5.04	103.45	1	ONC(=O)\C=C\c1ccc(OC[C@H](Cc2c[nH]c3ccccc23)NC(=O)c4ccc(Cl)cc4)cc1	14570588	IC50	=	498.1	nM	6.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1337840	CHEMBL3240668	B	Inhibition of HDAC2 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82316	CHEMBL3232921	24694055	J. Med. Chem.	2014	57	8	3324			
CHEMBL3527525	1925233	CHEMBL3527525	1925233		M4	333.43	3.18	70.91	0	Cc1[nH]c2ccccc2c1CCNCc3ccc(\C=C\C(=O)N)cc3	15462118	IC50	=	29000	nM	4.54			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1484269	CHEMBL3538485	B	Inhibition of flag-tagged HDAC2 (unknown origin) expressed in SF21 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation counting	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91925	CHEMBL3526051	22344701	Drug Metab. Dispos.	2012	40	5	1041			
CHEMBL3311471	1780581	CHEMBL3311471	1780581		19	331.37	1.27	107.53	0	ONC(=O)CCCCCCNC(=O)c1ccc2NC(=O)C=Cc2c1	15053555	IC50	=	25	nM	7.6			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1450057	CHEMBL3373319	B	Inhibition of human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90190	CHEMBL3351757	24864038	Bioorg. Med. Chem.	2014	22	14	3720			
CHEMBL3335283	1791416	CHEMBL3335283	1791416		5	349.43	4.01	67.15	0	ONC(=O)CCCCc1ccn(Cc2cccc(c2)c3ccccc3)n1	15076859	IC50	=	397	nM	6.4			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1433878	CHEMBL3388839	B	Inhibition of human recombinant HDAC2 after 60 mins by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89339	CHEMBL3352093	25218912	Eur. J. Med. Chem.	2014	86		639			
CHEMBL466215	479351	CHEMBL466215	479351		20	537.65	4.81	125.89	1	COc1ccc2[nH]c(C)c(CC(=O)N[C@@H](CCCCCC(=O)N)c3ncc([nH]3)c4ccc5ccccc5c4)c2c1	2637846	IC50	=	160	nM	6.8			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	500776	CHEMBL971455	B	Inhibition of C-terminal FLAG tagged HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			46717	CHEMBL1136904	19410459	Bioorg. Med. Chem. Lett.	2009	19	11	3081			
CHEMBL1767031	1142070	CHEMBL1767031	1142070		15	356.42	2.33	103.68	0	CNC(=O)\C(=N/O)\CCCCCCC(=O)Nc1cnc2ccccc2c1	6174067	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL1771485	1143796	CHEMBL1771485	1143796		A14B4	337.33	2.87	100.02	0	ONC(=O)c1cccc(c1)C(=O)N\N=C\c2ccc(OCC#C)cc2	6182568	IC50	=	6300	nM	5.2			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	744275	CHEMBL1772082	B	Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			57403	CHEMBL1770095	21334896	Bioorg. Med. Chem. Lett.	2011	21	9	2601			
CHEMBL235842	399341	CHEMBL235842	399341		19	351.42	2.46	112.46	0	CC(=O)Nc1ccc(cc1)C(=O)Nc2cc(ccc2N)c3cccs3	1998345	Inhibition	<	50	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	451049	CHEMBL900130	B	Inhibition of human recombinant HDAC2 at 20 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL235842	399341	CHEMBL235842	399341		19	351.42	2.46	112.46	0	CC(=O)Nc1ccc(cc1)C(=O)Nc2cc(ccc2N)c3cccs3	1998287	IC50	=	100	nM	7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL2436596	1585747	CHEMBL2436596	1585747		10	959.19	3.55	346.97	2	CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c3coc(CNC(=O)C[C@H](OC1=O)\C=C\CCSSCC\C=C\[C@@H]4CC(=O)NCc5occ(n5)C6=N[C@@](C)(CS6)C(=O)N[C@@H](C(C)C)C(=O)O4)n3	13472701	IC50	=	1300	nM	5.89			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	988355	CHEMBL2437618	B	Inhibition of HDAC2 (unknown origin) using MAZ1600 and MAZ1675 as substrate assessed as fluorogenic release of 7-amino-4-methylcoumarin from substrate by optimized homogenous assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	75140	CHEMBL2434914	24035339	Bioorg. Med. Chem. Lett.	2013	23	21	6025			
CHEMBL466032	479448	CHEMBL466032	479448		9	371.41	3.34	133.56	0	OC(=O)c1cc(CCCCC(=O)Nc2nc(cs2)c3ccccc3)on1	2641982	IC50	>	30000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	500548	CHEMBL971413	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			46730	CHEMBL1136917	19419863	Bioorg. Med. Chem. Lett.	2009	19	11	3023			
CHEMBL235842	399341	CHEMBL235842	399341		50a	351.42	2.46	112.46	0	CC(=O)Nc1ccc(cc1)C(=O)Nc2cc(ccc2N)c3cccs3	3328510	IC50	=	100	nM	7			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	638008	CHEMBL1166729	B	Inhibition of recombinant HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51491	CHEMBL1165890	20223566	Eur. J. Med. Chem.	2010	45	6	2095			
CHEMBL1800382	1161446	CHEMBL1800382	1161446		29	240.32	2.82	88.38	0	Cc1cc(O)nc(SCC(=O)C(C)(C)C)n1	6283052	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL96051	158844	CHEMBL96051	158844	SCRIPTAID	3	326.35	2.12	86.71	0	ONC(=O)CCCCCN1C(=O)c2cccc3cccc(C1=O)c23	3480810	IC50	=	700	nM	6.15			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	672869	CHEMBL1267844	B	Inhibition of HDAC2 by in vitro deacetylation assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			53324	CHEMBL1255383	19966789	Nat. Chem. Biol.	2010	6	1	25			
CHEMBL146250	246802	CHEMBL146250	246802		73 redFK	542.71	1.53	220.29	2	C\C=C\1/NC(=O)[C@@H](CS)NC(=O)[C@H](NC(=O)C[C@H](OC(=O)[C@@H](NC1=O)C(C)C)\C=C\CCS)C(C)C	180807	IC50	=	3.9	nM	8.41			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	87876	CHEMBL697298	B	Inhibitory concentration against human Histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	17295	CHEMBL1145900	14613312	J. Med. Chem.	2003	46	24	5097			
CHEMBL236060	399342	CHEMBL236060	399342		20	264.28	1.33	80.9	0	Nc1ccccc1NC(=O)c2ccc3nccnc3c2	1998286	IC50	=	2000	nM	5.7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL469134	479373	CHEMBL469134	479373		6	386.42	2.73	145.58	0	ONC(=O)c1cc(CCCCC(=O)Nc2nc(cs2)c3ccccc3)on1	2641979	IC50	=	430	nM	6.37			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	500548	CHEMBL971413	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46730	CHEMBL1136917	19419863	Bioorg. Med. Chem. Lett.	2009	19	11	3023			
CHEMBL466031	479447	CHEMBL466031	479447		8	357.43	2.9	116.49	0	OCc1cc(CCCCC(=O)Nc2nc(cs2)c3ccccc3)on1	2641981	IC50	>	30000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	500548	CHEMBL971413	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			46730	CHEMBL1136917	19419863	Bioorg. Med. Chem. Lett.	2009	19	11	3023			
CHEMBL466033	479449	CHEMBL466033	479449		10	370.43	2.72	139.35	0	NC(=O)c1cc(CCCCC(=O)Nc2nc(cs2)c3ccccc3)on1	2641983	IC50	>	30000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	500548	CHEMBL971413	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			46730	CHEMBL1136917	19419863	Bioorg. Med. Chem. Lett.	2009	19	11	3023			
CHEMBL511715	479450	CHEMBL511715	479450		11	354.36	1.97	117.35	0	ONC(=O)c1cc(CCCCC(=O)Nc2cnc3ccccc3c2)on1	2641984	IC50	=	469	nM	6.33			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	500548	CHEMBL971413	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46730	CHEMBL1136917	19419863	Bioorg. Med. Chem. Lett.	2009	19	11	3023			
CHEMBL466171	479514	CHEMBL466171	479514		14	309.36	2.07	104.46	0	ONC(=O)c1cc(CCCCC(=O)NC2CCCCC2)on1	2641987	IC50	>	30000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	500548	CHEMBL971413	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			46730	CHEMBL1136917	19419863	Bioorg. Med. Chem. Lett.	2009	19	11	3023			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	2641989	IC50	=	282	nM	6.55			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	500548	CHEMBL971413	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46730	CHEMBL1136917	19419863	Bioorg. Med. Chem. Lett.	2009	19	11	3023			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	2569568	IC50	=	14	nM	7.85			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	514670	CHEMBL976442	B	Inhibition of HDAC2 after 17 hrs	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			44070	CHEMBL1155917	18642892	J. Med. Chem.	2008	51	15	4370			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	2569569	IC50	=	282	nM	6.55			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	514670	CHEMBL976442	B	Inhibition of HDAC2 after 17 hrs	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			44070	CHEMBL1155917	18642892	J. Med. Chem.	2008	51	15	4370			
CHEMBL468841	488396	CHEMBL468841	488396		10	318.33	.88	130.48	0	Nc1ccc(cc1)c2onc(c2)C(=O)NCCCCC(=O)NO	2569571	IC50	=	1050	nM	5.98			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	514670	CHEMBL976442	B	Inhibition of HDAC2 after 17 hrs	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			44070	CHEMBL1155917	18642892	J. Med. Chem.	2008	51	15	4370			
CHEMBL511749	488393	CHEMBL511749	488393		7	446.5	3.23	142.79	0	CC(C)(C)OC(=O)Nc1ccc(cc1)c2onc(c2)C(=O)NCCCCCCC(=O)NO	2569574	IC50	=	252	nM	6.6			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	514670	CHEMBL976442	B	Inhibition of HDAC2 after 17 hrs	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			44070	CHEMBL1155917	18642892	J. Med. Chem.	2008	51	15	4370			
CHEMBL446512	488318	CHEMBL446512	488318		6	318.33	.88	130.47	0	Nc1cccc(c1)c2onc(c2)C(=O)NCCCCC(=O)NO	2569575	IC50	=	1940	nM	5.71			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	514670	CHEMBL976442	B	Inhibition of HDAC2 after 17 hrs	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			44070	CHEMBL1155917	18642892	J. Med. Chem.	2008	51	15	4370			
CHEMBL467998	488610	CHEMBL467998	488610		2	303.31	1.62	104.46	0	ONC(=O)CCCCNC(=O)c1cc(on1)c2ccccc2	2569579	IC50	=	1690	nM	5.77			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	514670	CHEMBL976442	B	Inhibition of HDAC2 after 17 hrs	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			44070	CHEMBL1155917	18642892	J. Med. Chem.	2008	51	15	4370			
CHEMBL555906	554221	CHEMBL555906	554221		13	255.27	2.59	69.56	0	ONC(=O)\C=C\c1cccc(c1)c2ccc(O)cc2	2657748	IC50	=	320	nM	6.49			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL541239	564776	CHEMBL541239	564776		11	269.34	3.77	49.33	0	ONC(=O)CCCCc1ccc(cc1)c2ccccc2	2657762	IC50	=	720	nM	6.14			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	5198517	IC50	=	7600	nM	5.12			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	716691	CHEMBL1670516	B	Inhibition of HDAC2 by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			55411	CHEMBL1667837	21256006	Bioorg. Med. Chem. Lett.	2011	21	4	1218			
CHEMBL1672332	1069553	CHEMBL1672332	1069553	BUTYRYLHYDROXAMIC ACID	2	103.12	.3	49.33	0	CCCC(=O)NO	5207860	IC50	=	9000	nM	5.05			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	718469	CHEMBL1680133	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	55650	CHEMBL1671826	21874153	ACS Med. Chem. Lett.	2011	2	1	39			
CHEMBL3215861	1704638	CHEMBL1851943	1192622		3, SB939	358.48	3.71	70.39	0	Cl.Cl.CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(CC)CC	6370654	Ki	=	27	nM	7.57			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	769058	CHEMBL1832521	B	Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58940	CHEMBL1828590	21634430	J. Med. Chem.	2011	54	13	4694			
CHEMBL1830420	1177126	CHEMBL1830420	1177126		10p	358.48	3.74	79.18	0	CCCCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCNCC	6370657	Ki	=	18	nM	7.74			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	769058	CHEMBL1832521	B	Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58940	CHEMBL1828590	21634430	J. Med. Chem.	2011	54	13	4694			
CHEMBL1830536	1177243	CHEMBL1830536	1177243		10x	356.46	3.29	79.18	0	CCNCCn1c(CC\C=C/CC)nc2cc(\C=C\C(=O)NO)ccc12	6370660	Ki	=	8.6	nM	8.07			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	769058	CHEMBL1832521	B	Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58940	CHEMBL1828590	21634430	J. Med. Chem.	2011	54	13	4694			
CHEMBL1830537	1177244	CHEMBL1830537	1177244		10y	358.48	3.66	79.18	0	CCCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCNC(C)C	6370661	Ki	=	14	nM	7.85			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	769058	CHEMBL1832521	B	Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58940	CHEMBL1828590	21634430	J. Med. Chem.	2011	54	13	4694			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA, Vorinostat, Zolinza	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	6370662	Ki	=	42	nM	7.38			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	769058	CHEMBL1832521	B	Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58940	CHEMBL1828590	21634430	J. Med. Chem.	2011	54	13	4694			
CHEMBL1448292	872176	CHEMBL1448292	872176		TM-2-105	284.38	3.82	73.22	0	O=C(NC(=S)NCCc1ccccc1)c2ccccc2	6376226	Inhibition					Not Active		0	BAO_0000376			771822	CHEMBL1838694	B	Inhibition of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1545737	969621	CHEMBL1545737	969621		TM-2-131	288.34	3.7	73.22	0	Fc1ccc(CNC(=S)NC(=O)c2ccccc2)cc1	6376228	Inhibition					Not Active		0	BAO_0000376			771822	CHEMBL1838694	B	Inhibition of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1834368	1178412	CHEMBL1834368	1178412		TM-2-130	284.38	3.87	73.22	0	C[C@@H](NC(=S)NC(=O)c1ccccc1)c2ccccc2	6376234	Inhibition	=	6	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	771822	CHEMBL1838694	B	Inhibition of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1834371	1178415	CHEMBL1834371	1178415		TM-2-107	276.38	3.24	101.46	0	O=C(NC(=S)NCc1cccs1)c2ccccc2	6376236	Inhibition	=	9	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	771822	CHEMBL1838694	B	Inhibition of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1448292	872176	CHEMBL1448292	872176		TM-2-105	284.38	3.82	73.22	0	O=C(NC(=S)NCCc1ccccc1)c2ccccc2	6377074	Activity					Not Active		0	BAO_0000375			771836	CHEMBL1838708	B	Activation of HDAC2 using Fluor-de-Lys as substrate at 10 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1545737	969621	CHEMBL1545737	969621		TM-2-131	288.34	3.7	73.22	0	Fc1ccc(CNC(=S)NC(=O)c2ccccc2)cc1	6377076	Activity					Not Active		0	BAO_0000375			771836	CHEMBL1838708	B	Activation of HDAC2 using Fluor-de-Lys as substrate at 10 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1448292	872176	CHEMBL1448292	872176		TM-2-105	284.38	3.82	73.22	0	O=C(NC(=S)NCCc1ccccc1)c2ccccc2	6376314	Activity					Not Active		0	BAO_0000375			771829	CHEMBL1838701	B	Activation of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1545737	969621	CHEMBL1545737	969621		TM-2-131	288.34	3.7	73.22	0	Fc1ccc(CNC(=S)NC(=O)c2ccccc2)cc1	6376316	Activity					Not Active		0	BAO_0000375			771829	CHEMBL1838701	B	Activation of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	7921742	IC50	=	100	nM	7			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	785884	CHEMBL1921153	B	Inhibition of human recombinant HDAC2 using fluorophore-conjugated substrate Boc-L-Lys(Ac)-AMC after 60 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	60081	CHEMBL1914352	21548582	J. Med. Chem.	2011	54	13	4350			
CHEMBL1923808	1267417	CHEMBL1089494	621495		1b, 19F-SAHA	282.31	2.21	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccc([19F])cc1	7955875	IC50	=	12.7	nM	7.9			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	789115	CHEMBL1925439	B	Inhibition of human recombinant full-length HDAC2 using fluorophore conjugated substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	60260	CHEMBL1921669	21721525	J. Med. Chem.	2011	54	15	5576			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	2, SAHA, Vorinostat	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	7955876	IC50	=	16	nM	7.8			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	789115	CHEMBL1925439	B	Inhibition of human recombinant full-length HDAC2 using fluorophore conjugated substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	60260	CHEMBL1921669	21721525	J. Med. Chem.	2011	54	15	5576			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	8048591	IC50	=	18	nM	7.74			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	807676	CHEMBL1959441	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			61262	CHEMBL1955769	22321215	Bioorg. Med. Chem. Lett.	2012	22	5	1926			
CHEMBL1958424	1283965	CHEMBL1958424	1283965		3	388.44	1.45	111.22	0	ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)N2CCN(CC2)c3ccccn3	8054605	ED50	=	55	nM			Non standard unit for type	0	BAO_0003036	UO_0000065	http://www.openphacts.org/units/Nanomolar	808465	CHEMBL1961041	B	Inhibition of human recombinant HDAC2 expressed using baculovirus expression system using Flour- De-Lys as substrate after 3 hrs by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			61278	CHEMBL1955831	22326398	Bioorg. Med. Chem. Lett.	2012	22	5	1886			
CHEMBL1958433	1283974	CHEMBL1958433	1283974		12	417.48	2.04	107.56	0	COc1ccccc1N2CCN(CC2)S(=O)(=O)c3cccc(\C=C\C(=O)NO)c3	8054615	ED50	=	310	nM			Non standard unit for type	0	BAO_0003036	UO_0000065	http://www.openphacts.org/units/Nanomolar	808465	CHEMBL1961041	B	Inhibition of human recombinant HDAC2 expressed using baculovirus expression system using Flour- De-Lys as substrate after 3 hrs by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			61278	CHEMBL1955831	22326398	Bioorg. Med. Chem. Lett.	2012	22	5	1886			
CHEMBL2048746	1352181	CHEMBL2048746	1352181		8, MPT0E014	342.37	2.96	96.78	0	ONC(=O)\C=C\c1ccc2c(ccn2S(=O)(=O)c3ccccc3)c1	10948224	IC50	=	4	nM	8.4			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	826885	CHEMBL2051700	B	Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62425	CHEMBL2046324	22439863	J. Med. Chem.	2012	55	8	3777			
CHEMBL2048749	1352184	CHEMBL2048749	1352184		11	372.4	2.95	106.01	0	COc1ccc(cc1)S(=O)(=O)n2ccc3cc(\C=C\C(=O)NO)ccc23	10948225	IC50	=	361.8	nM	6.44			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	826885	CHEMBL2051700	B	Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62425	CHEMBL2046324	22439863	J. Med. Chem.	2012	55	8	3777			
CHEMBL2048752	1352187	CHEMBL2048752	1352187		14	387.37	2.86	142.6	0	ONC(=O)\C=C\c1ccc2c(ccn2S(=O)(=O)c3ccc(cc3)[N+](=O)[O-])c1	10948228	IC50	=	189.3	nM	6.72			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	826885	CHEMBL2051700	B	Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62425	CHEMBL2046324	22439863	J. Med. Chem.	2012	55	8	3777			
CHEMBL2048755	1352190	CHEMBL2048755	1352190		17	292.33	3.4	54.26	0	ONC(=O)\C=C\c1ccc2c(ccn2Cc3ccccc3)c1	10948229	IC50	=	381.1	nM	6.42			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	826885	CHEMBL2051700	B	Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62425	CHEMBL2046324	22439863	J. Med. Chem.	2012	55	8	3777			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	1, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	10948230	IC50	=	1.7	nM	8.77			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	826885	CHEMBL2051700	B	Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62425	CHEMBL2046324	22439863	J. Med. Chem.	2012	55	8	3777			
CHEMBL3287255	1757780	CHEMBL3287255	1757780		8f	366.46	1.5	160.69	0	ONC(=O)CCCCNC(=O)c1nc(sc1C2CC2)c3nccs3	14733144	Inhibition					Active		0	BAO_0000376			1364651	CHEMBL3293473	B	Inhibition of recombinant human HDAC2 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			83990	CHEMBL3286308	24944733	ACS Med. Chem. Lett.	2014	5	6	628			
CHEMBL3233696	1732202	CHEMBL3233696	1732202		11p	469.53	4.41	103.45	0	ONC(=O)\C=C\c1ccc(OC[C@H](Cc2c[nH]c3ccccc23)NC(=O)Cc4ccccc4)cc1	14570587	IC50	=	432.1	nM	6.36			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1337840	CHEMBL3240668	B	Inhibition of HDAC2 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82316	CHEMBL3232921	24694055	J. Med. Chem.	2014	57	8	3324			
CHEMBL3233703	1732209	CHEMBL3233703	1732209		11w	473.5	4.59	103.45	0	ONC(=O)\C=C\c1ccc(OC[C@H](Cc2c[nH]c3ccccc23)NC(=O)c4ccc(F)cc4)cc1	14570589	IC50	=	457	nM	6.34			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1337840	CHEMBL3240668	B	Inhibition of HDAC2 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82316	CHEMBL3232921	24694055	J. Med. Chem.	2014	57	8	3324			
CHEMBL3233705	1732211	CHEMBL3233705	1732211		11y	485.53	4.36	112.68	0	COc1ccc(cc1)C(=O)N[C@H](COc2ccc(\C=C\C(=O)NO)cc2)Cc3c[nH]c4ccccc34	14570590	IC50	=	413.6	nM	6.38			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1337840	CHEMBL3240668	B	Inhibition of HDAC2 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82316	CHEMBL3232921	24694055	J. Med. Chem.	2014	57	8	3324			
CHEMBL3233708	1732214	CHEMBL3304235	1766206		21c	475.97	5.37	86.38	1	Cl.ONC(=O)\C=C\c1ccc(OC[C@H](Cc2c[nH]c3ccccc23)NCc4ccc(Cl)cc4)cc1	14570591	IC50	=	791.2	nM	6.1			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1337840	CHEMBL3240668	B	Inhibition of HDAC2 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82316	CHEMBL3232921	24694055	J. Med. Chem.	2014	57	8	3324			
CHEMBL3233711	1732217	CHEMBL3233711	1732217		27c	489.95	5.04	103.45	1	ONC(=O)\C=C\c1cccc(OC[C@H](Cc2c[nH]c3ccccc23)NC(=O)c4ccc(Cl)cc4)c1	14570592	IC50	=	498.5	nM	6.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1337840	CHEMBL3240668	B	Inhibition of HDAC2 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82316	CHEMBL3232921	24694055	J. Med. Chem.	2014	57	8	3324			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SA, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	14570593	IC50	=	184.7	nM	6.73			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1337840	CHEMBL3240668	B	Inhibition of HDAC2 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	82316	CHEMBL3232921	24694055	J. Med. Chem.	2014	57	8	3324			
CHEMBL2364628	1540500	CHEMBL2364628	1540500	RICOLINOSTAT	5, ACY-1215	433.5	3.92	107.45	0	ONC(=O)CCCCCCNC(=O)c1cnc(nc1)N(c2ccccc2)c3ccccc3	14660296	IC50	=	48	nM	7.32			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1349595	CHEMBL3265664	B	Inhibition of HDAC2 (unknown origin) using RHKK(Ac) (379 to 382) p53 peptide as substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	83197	CHEMBL3259569	24766560	J. Med. Chem.	2014	57	10	4009			
CHEMBL2178345	1439139	CHEMBL2178345	1439139		C31	294.31	2.56	80.04	0	ONC(=O)c1cccc(c1)c2cn(Cc3ccccc3)nn2	12148687	IC50	=	65000	nM	4.19			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	878901	CHEMBL2185052	B	Inhibition of HDAC2 by fluorometric assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			66685	CHEMBL2176939	23116147	J. Med. Chem.	2012	55	22	9562			
CHEMBL2347007	1528831	CHEMBL2347007	1528831		13, simva-HA	451.6	3.44	116.09	0	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)NO)[C@@H]12	12718183	IC50	=	414.2	nM	6.38			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	950484	CHEMBL2351477	B	Inhibition of recombinant HDAC2 (unknown origin) after 10 mins by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72873	CHEMBL2346500	23570542	J. Med. Chem.	2013	56	9	3645			
CHEMBL255714	425611	CHEMBL255714	425611	AZUMAMIDE A	5, azuA	513.63	1.18	159.48	1	CC(C)[C@H]1NC(=O)[C@@H](C)[C@@H](C\C=C/CCC(=O)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	13431795	Ki	>	5000	nM				0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	979441	CHEMBL2423477	B	Inhibition of recombinant human HDAC2 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74596	CHEMBL2417416	23865683	J. Med. Chem.	2013	56	16	6512			
CHEMBL3417212	1840420	CHEMBL3417212	1840420		6d	677.77	5.22	166.45	2	COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(=O)c4cccc(c4)C(=O)Nc5cc(ccc5N)c6cccs6	15218919	IC50	=	190	nM	6.72			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1471124	CHEMBL3421014	B	Inhibition of recombinant human HDAC2 expressed in baculovirus infected insect High5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91571	CHEMBL3414494	25805446	Eur. J. Med. Chem.	2015	95		127			
CHEMBL3421750	1841186	CHEMBL3421750	1841186		11d	392.33	2.49	100.28	0	ONC(=O)c1ccc(CNCc2onc(n2)c3ccc(cc3)C(F)(F)F)cc1	15234979	IC50	>	10000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL3356920	1821063	CHEMBL3356920	1821063		145, ST8085	363.47	1.58	126.1	0	SCCCCC[C@@H](NC(=O)[C@H]1CCC(=O)N1)C(=O)Nc2ccccc2	15138235	IC50	=	171	nM	6.77			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3356918	1821061	CHEMBL3356918	1821061		81, ST8077	363.47	1.58	126.1	0	SCCCCC[C@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)Nc2ccccc2	15138237	IC50	=	33	nM	7.48			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	zolinza	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	2073909	IC50	=	170	nM	6.77			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	461756	CHEMBL927762	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38240	CHEMBL1140803	18060775	Bioorg. Med. Chem. Lett.	2008	18	2	726			
CHEMBL389688	382033	CHEMBL389688	382033		8	541.64	4.02	149.34	2	N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc3ccccc3c4ccc(NC(=O)CCCCCCC(=O)NO)cc4	1902510	IC50	=	167	nM	6.78			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	439074	CHEMBL889422	B	Inhibition of His-tagged HDAC2 expressed in Sf9 cells by fluorescence-based assay	1	Scientific Literature				Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			36060	CHEMBL1145385	17539623	J. Med. Chem.	2007	50	13	3054	1759	CHEMBL3308860	Sf9
CHEMBL251012	416385	CHEMBL251012	416385		15	400.47	3.19	96.89	0	COc1ccc(CO[C@@H](CCCCCC(=O)NO)C(=O)Nc2ccccc2)cc1	2049533	IC50	>=	50	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA, vorinostat	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	2049515	IC50	>=	50	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL2048750	1352185	CHEMBL2048750	1352185		12	402.42	2.93	115.24	0	COc1ccc(cc1OC)S(=O)(=O)n2ccc3cc(\C=C\C(=O)NO)ccc23	10948226	IC50	=	2.3	nM	8.64			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	826885	CHEMBL2051700	B	Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62425	CHEMBL2046324	22439863	J. Med. Chem.	2012	55	8	3777			
CHEMBL27759	36237	CHEMBL27759	36237	ENTINOSTAT	3, MS-275	376.41	2.07	106.33	0	Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2	1998254	IC50	=	500	nM	6.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	451041	CHEMBL900122	B	Inhibition of human recombinant HDAC2	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37159	CHEMBL1138236	17941625	J. Med. Chem.	2007	50	23	5543			
CHEMBL250828	416524	CHEMBL250828	416524		10d	414.49	3.65	96.89	0	COc1ccc(COC(CCCCCCC(=O)NO)C(=O)Nc2ccccc2)cc1	2049592	Activity					Not Active		0	BAO_0000375			458150	CHEMBL925483	B	Inhibition of HDAC2 in HeLa cell lysates at 0.1 uM	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL258131	436345	CHEMBL258131	436345		12	380.46	1.64	138.47	0	CNC(=O)C(N)c1ccc(cc1)C(=O)Nc2cc(ccc2N)c3cccs3	2116589	Activity	=	130	nM				0	BAO_0000181	UO_0000065	http://www.openphacts.org/units/Nanomolar	466096	CHEMBL934352	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38589	CHEMBL1142361	18304810	Bioorg. Med. Chem. Lett.	2008	18	6	1859			
CHEMBL269935	436432	CHEMBL269935	436432		1	289.33	3.89	49.33	0	Oc1ccc(cc1NC(=O)c2ccccc2)c3ccccc3	2116611	Activity	=	200	nM				0	BAO_0000181	UO_0000065	http://www.openphacts.org/units/Nanomolar	466096	CHEMBL934352	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38589	CHEMBL1142361	18304810	Bioorg. Med. Chem. Lett.	2008	18	6	1859			
CHEMBL27759	36237	CHEMBL27759	36237	ENTINOSTAT	4, MS-275	376.41	2.07	106.33	0	Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2	2161830	IC50	=	250	nM	6.6			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	476820	CHEMBL932445	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			39330	CHEMBL1144784	18370373	J. Med. Chem.	2008	51	8	2350			
CHEMBL269935	436432	CHEMBL269935	436432		6	289.33	3.89	49.33	0	Oc1ccc(cc1NC(=O)c2ccccc2)c3ccccc3	2401159	IC50	=	200	nM	6.7			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	493107	CHEMBL940370	B	Inhibition of human HDAC2 expressed in mammalian cells	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45872	CHEMBL1152282	18951790	Bioorg. Med. Chem. Lett.	2008	18	23	6104			
CHEMBL482358	474723	CHEMBL482358	474723		7h	401.46	3.89	81.67	0	ONC(=O)c1ccc(CN2[C@H](CCc3ccccc3)C(=O)Nc4ccccc24)cc1	2489481	IC50	=	520	nM	6.28			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	515266	CHEMBL991290	B	Inhibition of human recombinant histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45582	CHEMBL1143301	19111466	Bioorg. Med. Chem. Lett.	2009	19	3	688			
CHEMBL519668	508340	CHEMBL519668	508340		10c	407.47	3.71	109.14	0	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)c2cn(nn2)c3ccccc3	2351863	IC50	=	63.9	nM	7.19			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL471041	521233	CHEMBL471041	521233		11, ST2986	386.27	3.79	70.92	0	ONC(=O)\C=C\c1ccc(\C=N\OCc2c(F)c(F)c(F)c(F)c2F)cc1	2409587	IC50	=	11000	nM	4.96			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	565674	CHEMBL960032	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46441	CHEMBL1153969	19285395	Bioorg. Med. Chem. Lett.	2009	19	8	2346			
CHEMBL561212	559443	CHEMBL561212	559443		3h	245.3	2.78	77.56	0	ONC(=O)\C=C\c1ccc(cc1)c2cccs2	2657752	IC50	=	450	nM	6.35			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL557066	566559	CHEMBL557066	566559		3c	273.71	3.5	49.33	0	ONC(=O)\C=C\c1ccc(cc1)c2ccc(Cl)cc2	2657786	IC50	=	1860	nM	5.73			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL470225	521671	CHEMBL470225	521671		13	473.52	2.87	140.72	0	CCOP(=O)(CNCc1ccc(cc1)C(=O)Nc2cc(ccc2N)c3cccs3)OCC	2412273	IC50	=	14	nM	7.85			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	564615	CHEMBL964055	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			46415	CHEMBL1153943	19268585	Bioorg. Med. Chem. Lett.	2009	19	7	2053			
CHEMBL55895	81957	CHEMBL55895	81957	PHENYLBUTYRYLHYDROXAMIC ACID	4-PBHA	179.22	1.79	49.33	0	ONC(=O)CCCc1ccccc1	3389982	Ki	=	430	nM	6.37			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL1164212	646043	CHEMBL1164212	646043		24b	449.69	4.44	108.36	0	C[C@H](CCCCNC(=O)CS)[C@H]1CC[C@H]2\C(=C\C=C3C[C@@H](O)C[C@H](O)C3)\CCC[C@]12C	3341236	IC50	=	96300	nM	4.02			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	639020	CHEMBL1166158	B	Inhibition of HDAC2 after 10 mins by fluorometric assay	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51523	CHEMBL1165922	20452225	Bioorg. Med. Chem.	2010	18	11	4119			
CHEMBL487943	508422	CHEMBL487943	508422		12d	530.41	3.82	129.37	1	ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)c2cnnn2CC(O)c3cccc(Br)c3	2351858	IC50	=	216	nM	6.67			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	556910	CHEMBL954936	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			42183	CHEMBL1150413	18494463	J. Med. Chem.	2008	51	12	3437			
CHEMBL470843	521387	CHEMBL1186582	660532		21, ST3710	329.35	1.55	87.83	0	Cl.ONC(=O)\C=C\c1ccc(cc1)c2cc(CN3CCOCC3)on2	2409631	IC50	=	13200	nM	4.88			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	565674	CHEMBL960032	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46441	CHEMBL1153969	19285395	Bioorg. Med. Chem. Lett.	2009	19	8	2346			
CHEMBL1213458	685302	CHEMBL1213458	685302		17, APHA	284.31	2.63	71.33	0	Cn1c(\C=C\C(=O)NO)ccc1C(=O)Cc2ccccc2	3389915	Ki	=	125	nM	6.9			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL27759	36237	CHEMBL27759	36237	ENTINOSTAT	19, MS-275	376.41	2.07	106.33	0	Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2	3389977	Ki	=	65	nM	7.19			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL1243289	702527	CHEMBL1243289	702527		4	305.33	1.24	100.02	0	ONC(=O)C1=NOC(CCCCC(=O)Nc2ccccc2)C1	3437992	IC50	=	36200	nM	4.44			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	658913	CHEMBL1246052	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			52747	CHEMBL1240475	20637529	Eur. J. Med. Chem.	2010	45	9	4331			
CHEMBL1097747	626285	CHEMBL1097747	626285		17	318.37	3.37	64.35	0	COc1cccc(c1)c2ccc(N)c(NC(=O)c3ccccc3)c2	3286439	Ratio IC50	=	2					0	BAO_0000179			630933	CHEMBL1116532	B	Selectivity ratio of IC50 for human recombinant HDAC2 preincubated for 1 hr with substrate to IC50 for human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1087053	614775	CHEMBL1087053	614775		12a	482.58	4.73	114.93	0	Nc1ccccc1NC(=O)CCCCCCC(=O)Nc2cccc(c2)n3cc(nn3)c4ccccc4	3201454	IC50	>	30000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	616013	CHEMBL1101057	B	Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			50398	CHEMBL1154884	20055418	J. Med. Chem.	2010	53	3	1347			
CHEMBL1097747	626285	CHEMBL1097747	626285		17	318.37	3.37	64.35	0	COc1cccc(c1)c2ccc(N)c(NC(=O)c3ccccc3)c2	3286377	IC50	=	1300	nM	5.89			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1097747	626285	CHEMBL1097747	626285		17	318.37	3.37	64.35	0	COc1cccc(c1)c2ccc(N)c(NC(=O)c3ccccc3)c2	3286397	IC50	=	3400	nM	5.47			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL356769	239841	CHEMBL356769	239841	TUBACIN	Tubacin	721.86	7.18	168.45	2	OCc1ccc(cc1)[C@@H]2C[C@H](CSc3oc(c4ccccc4)c(n3)c5ccccc5)O[C@@H](O2)c6ccc(NC(=O)CCCCCCC(=O)NO)cc6	3328995	IC50	=	260	nM	6.59			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	639057	CHEMBL1166310	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51553	CHEMBL1165952	20472442	Bioorg. Med. Chem.	2010	18	11	4103			
CHEMBL1767032	1142071	CHEMBL1767032	1142071		16	393.48	3.45	90.79	0	CNC(=O)\C(=N/O)\CCCCCCC(=O)NC1c2ccccc2c3ccccc13	6174068	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL2407728	1572134	CHEMBL2407728	1572134		8h	530.58	4.24	132.12	1	Nc1cc(ccc1NC(=O)c2ccc(CNc3nccc(n3)c4cccnc4)cc2)C(=O)OCc5ccccc5	13395020	IC50	>	20000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL2407740	1572146	CHEMBL2407740	1572146		8b	472.54	4.32	105.82	0	Nc1cc(ccc1NC(=O)c2ccc(CNc3nccc(n3)c4cccnc4)cc2)c5ccccc5	13395026	IC50	=	16700	nM	4.78			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL3356919	1821062	CHEMBL3356919	1821062		128, ST7464	363.47	1.58	126.1	0	SCCCCC[C@@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)Nc2ccccc2	15138236	IC50	=	78	nM	7.11			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3356933	1821076	CHEMBL3356933	1821076		131, ST7893	459.53	2.99	126.1	0	FC(F)(F)c1ccc(CNC(=O)[C@H](CCCCCS)NC(=O)[C@@H]2CCCC(=O)N2)cc1	15138288	IC50	=	1770	nM	5.75			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3352993	1817096	CHEMBL3352993	1817096		7a	502.6	1.79	153.69	1	CC(C)[C@H]1NC(=O)C[C@@H](CCCCCC(=O)O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	15126325	Ki	=	800	nM	6.1			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	1440125	CHEMBL3382538	B	Inhibition of human recombinant HDAC2 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89689	CHEMBL3351463	25380299	J. Med. Chem.	2014	57	22	9644			
CHEMBL2022828	1338201	CHEMBL2022828	1338201		7	597.79	7.86	130.92	2	O=C(N[C@@H](CCCCCCSSc1ccccn1)C(=O)NC2c3ccccc3c4ccccc24)OCc5ccccc5	10862536	IC50	=	48.1	nM	7.32			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	816365	CHEMBL2024763	B	Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	61731	CHEMBL2021837	22465091	Eur. J. Med. Chem.	2012	52		111			
CHEMBL402363	426196	CHEMBL402363	426196	AZUMAMIDE E	azumamide E	514.61	1.8	153.69	1	CC(C)[C@H]1NC(=O)[C@@H](C)[C@@H](C\C=C/CCC(=O)O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	2106251	IC50	=	100	nM	7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	464924	CHEMBL946981	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38494	CHEMBL1142268	18247554	J. Med. Chem.	2008	51	6	1505			
CHEMBL2047607	1351031	CHEMBL2047607	1351031		5c	458.35	6.49	46.92	1	Cc1ccc(cc1)c2nn(cc2\C=C/C(=O)Nc3ccc(Br)cc3)c4ccccc4	10947974	IC50	=	5020	nM	5.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	827843	CHEMBL2051252	B	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62524	CHEMBL2046430	22705022	Bioorg. Med. Chem.	2012	20	14	4430			
CHEMBL3356928	1821071	CHEMBL3356928	1821071		48, ST7544	439.57	2.92	126.1	0	SCCCCC[C@H](NC(=O)[C@@H]1[C@@H](CNC1=O)c2ccccc2)C(=O)Nc3ccccc3	15138283	IC50	=	1900	nM	5.72			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL400760	416391	CHEMBL400760	416391		7f	449.34	3.96	87.66	0	ONC(=O)CCCCCC(OCc1ccc(Br)cc1)C(=O)Nc2ccccc2	2049530	IC50	>=	50	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL427510	304477	CHEMBL427510	304477		12	309.43	1.33	100.24	0	CN(C)c1ccc(cc1)C(=O)NCCCCNC(=O)CS	1902506	IC50	>	30000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	439074	CHEMBL889422	B	Inhibition of His-tagged HDAC2 expressed in Sf9 cells by fluorescence-based assay	1	Scientific Literature				Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			36060	CHEMBL1145385	17539623	J. Med. Chem.	2007	50	13	3054	1759	CHEMBL3308860	Sf9
CHEMBL1643315	1057873	CHEMBL1643315	1057873		5z	566.61	4.4	105.48	1	Nc1ccccc1NC(=O)\C=C\c2ccc(cc2)C(NCCC3CCOCC3)C(=O)Nc4ccc(cc4)C(F)(F)F	5122779	IC50	=	800	nM	6.1			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	700124	CHEMBL1647006	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			54702	CHEMBL1641604	21145737	Bioorg. Med. Chem. Lett.	2011	21	1	110			
CHEMBL1834370	1178414	CHEMBL1834370	1178414		TM-2-125	406.35	5.38	73.22	1	FC(F)(F)c1cc(CNC(=S)NC(=O)c2ccccc2)cc(c1)C(F)(F)F	6376229	Inhibition					Not Active		0	BAO_0000376			771822	CHEMBL1838694	B	Inhibition of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1834366	1178410	CHEMBL1834366	1178410		TM-2-101	346.45	5.01	73.22	1	O=C(NC(=S)NCc1ccc(cc1)c2ccccc2)c3ccccc3	6376232	Inhibition	=	10	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	771822	CHEMBL1838694	B	Inhibition of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1834370	1178414	CHEMBL1834370	1178414		TM-2-125	406.35	5.38	73.22	1	FC(F)(F)c1cc(CNC(=S)NC(=O)c2ccccc2)cc(c1)C(F)(F)F	6377077	Activity					Not Active		0	BAO_0000375			771836	CHEMBL1838708	B	Activation of HDAC2 using Fluor-de-Lys as substrate at 10 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1834370	1178414	CHEMBL1834370	1178414		TM-2-125	406.35	5.38	73.22	1	FC(F)(F)c1cc(CNC(=S)NC(=O)c2ccccc2)cc(c1)C(F)(F)F	6376317	Activity					Not Active		0	BAO_0000375			771829	CHEMBL1838701	B	Activation of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL2170186	1429667	CHEMBL2170186	1429667		5	595.77	3.3	122.88	1	CCC(=O)CCCCC[C@@H]1NC(=O)[C@H](C)N(C)C(=O)CCN(CC(C)C)C(=O)CN(CCc2c[nH]c3ccccc23)C1=O	12103873	IC50	=	2000	nM	5.7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	861541	CHEMBL2174389	B	Inhibition of human recombinant HDAC2 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	65900	CHEMBL2169795		ACS Med. Chem. Lett.	2012	3	9	749			
CHEMBL2333346	1522984	CHEMBL2333346	1522984		14, BRD9757	127.14	.81	49.33	0	ONC(=O)C1=CCCC1	12680988	IC50	=	1790	nM	5.75			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	944722	CHEMBL2340968	B	Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772			
CHEMBL2333346	1522984	CHEMBL2333346	1522984		14, BRD9757	127.14	.81	49.33	0	ONC(=O)C1=CCCC1	12678228	Inhibition					Not Active		0	BAO_0000376			944716	CHEMBL2340962	B	Inhibition of HDAC2 in human HeLa cells assessed as increase in acetylated H3 at 30 uM measured after 24 hrs by Western blotting analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			72522	CHEMBL2331470	23368884	J. Med. Chem.	2013	56	4	1772	308	CHEMBL3308376	HeLa
CHEMBL2407738	1572144	CHEMBL2407738	1572144		30a	433.59	5.41	118.08	1	Nc1ccccc1NC(=O)c2ccc(CSC3=N[C@@H](Cc4ccccc4)CS3)cc2	13395010	IC50	=	580	nM	6.24			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL2435340	1584478	CHEMBL2435340	1584478		1,2-HOPO-2	320.34	2.23	69.64	0	ON1C(=O)C=CC=C1C(=O)NCc2ccc(cc2)c3ccccc3	13488733	Inhibition					Not Active		0	BAO_0000376			987733	CHEMBL2439711	B	Inhibition of HDAC2 (unknown origin)-mediated deacetylation at 10 uM preincubated for 5 mins prior to substrate addition measured after 30 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			75182	CHEMBL2434956	24074025	J. Med. Chem.	2013	56	20	7997			
CHEMBL3098694	1609465	CHEMBL3098694	1609465		14	466.53	1.74	136.63	0	ONC(=O)CCCCC[C@H](NC(=O)C1C(CNC1=O)c2ccccc2)C(=O)Nc3ccccc3	13867807	IC50	=	110	nM	6.96			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL3417209	1840417	CHEMBL3417209	1840417		6a	595.64	3.75	138.2	1	COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(=O)c4ccc(cc4)C(=O)Nc5ccccc5N	15218907	IC50	=	10420	nM	4.98			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1471124	CHEMBL3421014	B	Inhibition of recombinant human HDAC2 expressed in baculovirus infected insect High5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91571	CHEMBL3414494	25805446	Eur. J. Med. Chem.	2015	95		127			
CHEMBL3421740	1841176	CHEMBL3421740	1841176		10d	467.44	3.52	106.07	0	Nc1ccccc1NC(=O)c2ccc(CNCc3onc(n3)c4ccc(cc4)C(F)(F)F)cc2	15234969	IC50	=	5930	nM	5.23			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL213934	354895	CHEMBL213934	354895		52, ST7306	344.51	3.53	106.22	0	CC(C)(C)OC(=O)N[C@@H](CCCCCS)C(=O)NC1CCCC1	15067392	Inhibition					Not Active		0	BAO_0000376			1443008	CHEMBL3379486	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate at <50 uM by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3427749	1845145	CHEMBL3427749	1845145		3f	310.18	3.91	71.77	0	NC(=O)C1CCCc2c1[nH]nc2c3ccc(Cl)cc3Cl	15255899	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL3427777	1845173	CHEMBL3427777	1845173		14	303.79	3.71	71.77	0	CC1(C)CCC(C(=O)N)c2[nH]nc(c3ccc(Cl)cc3)c12	15256004	Inhibition					Not Active		0	BAO_0000376			1476848	CHEMBL3429771	B	Inhibition of HDAC2 (unknown origin)	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91838	CHEMBL3425433	25971769	Bioorg. Med. Chem. Lett.	2015	25	12	2514			
CHEMBL472631	521236	CHEMBL472631	521236		14, ST3050	319.36	1	83.39	0	ONC(=O)\C=C\c1ccc(\C=N\OCCN2CCOCC2)cc1	2409620	IC50	=	27700	nM	4.56			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	565674	CHEMBL960032	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46441	CHEMBL1153969	19285395	Bioorg. Med. Chem. Lett.	2009	19	8	2346			
CHEMBL2407735	1572141	CHEMBL2407735	1572141		19a	413.47	2.76	108.61	0	Nc1ccccc1NC(=O)c2ccc(CNC3=NC(=O)C(Cc4ccccc4)N3)cc2	13395013	IC50	=	66	nM	7.18			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL271741	435638	CHEMBL271741	435638		2	288.34	3.39	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccccc3	2116630	Activity	=	780	nM				0	BAO_0000181	UO_0000065	http://www.openphacts.org/units/Nanomolar	466096	CHEMBL934352	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38589	CHEMBL1142361	18304810	Bioorg. Med. Chem. Lett.	2008	18	6	1859			
CHEMBL271741	435638	CHEMBL271741	435638		5	288.34	3.39	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccccc3	3286369	Ratio IC50	=	33					0	BAO_0000179			630933	CHEMBL1116532	B	Selectivity ratio of IC50 for human recombinant HDAC2 preincubated for 1 hr with substrate to IC50 for human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL271741	435638	CHEMBL271741	435638		5	288.34	3.39	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccccc3	3286389	IC50	=	27	nM	7.57			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630931	CHEMBL1116530	B	Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL271741	435638	CHEMBL271741	435638		5	288.34	3.39	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccccc3	3286409	IC50	=	900	nM	6.05			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	630930	CHEMBL1116529	B	Inhibition of human recombinant HDAC2 preincubated for 1 hr with substrate by protease coupled end-point assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL398420	423436	CHEMBL398420	423436		14f	375.42	3.16	93.44	0	COC(=O)NCc1ccc(cc1)C(=O)Nc2cc(ccc2N)c3ccccc3	2073946	IC50	=	13	nM	7.89			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	461756	CHEMBL927762	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38240	CHEMBL1140803	18060775	Bioorg. Med. Chem. Lett.	2008	18	2	726			
CHEMBL3356917	1821060	CHEMBL3356917	1821060		130, ST8000	391.53	2.53	126.1	0	Cc1ccc(NC(=O)[C@H](CCCCCS)NC(=O)[C@@H]2CCCC(=O)N2)cc1	15138238	IC50	=	60	nM	7.22			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL248798	416395	CHEMBL248798	416395		7i	520.62	4.97	97.33	1	COc1cccc(COC(CCCCCC(=O)NO)C(=O)N(Cc2cccc(OC)c2)c3ccccc3)c1	2049519	IC50	=	500	nM	6.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	458149	CHEMBL925482	B	Inhibition of HDAC2 in HeLa cell lysates	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	37865	CHEMBL1140532	17892933	Bioorg. Med. Chem. Lett.	2007	17	22	6261			
CHEMBL407959	429751	CHEMBL407959	429751		17	486.61	4.62	99.87	0	COc1ccc2[nH]c(C)c(CC(=O)N[C@@H](CCCCCC(=O)C)c3ncc([nH]3)c4ccccc4)c2c1	2161829	IC50	=	110	nM	6.96			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	476820	CHEMBL932445	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			39330	CHEMBL1144784	18370373	J. Med. Chem.	2008	51	8	2350			
CHEMBL269935	436432	CHEMBL269935	436432		2	289.33	3.89	49.33	0	Oc1ccc(cc1NC(=O)c2ccccc2)c3ccccc3	2099119	IC50	=	200	nM	6.7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	468835	CHEMBL947922	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38804	CHEMBL1143185	18182289	Bioorg. Med. Chem. Lett.	2008	18	3	973			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	2106282	IC50					Not Determined		0	BAO_0000190			464924	CHEMBL946981	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38494	CHEMBL1142268	18247554	J. Med. Chem.	2008	51	6	1505			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	2409642	IC50	=	23	nM	7.64			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	565674	CHEMBL960032	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46441	CHEMBL1153969	19285395	Bioorg. Med. Chem. Lett.	2009	19	8	2346			
CHEMBL538712	554213	CHEMBL538712	554213		3i	282.34	2.99	52.57	0	CN(C)c1ccc(cc1)c2ccc(\C=C\C(=O)NO)cc2	2658572	IC50	>	5000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL538967	554215	CHEMBL538967	554215		10a	265.31	3.3	49.33	0	ONC(=O)\C=C\C=C\c1ccc(cc1)c2ccccc2	2658573	IC50	>	5000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL551549	564777	CHEMBL551549	564777		18	263.33	3.05	69.56	0	ONC(=O)CCC1CCC(CC1)c2ccc(O)cc2	2658598	IC50					Not Determined		0	BAO_0000190			571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL1098337	626352	CHEMBL1098337	626352		20	306.33	3.59	55.12	0	Nc1ccc(cc1NC(=O)c2ccccc2)c3ccc(F)cc3	3286441	Ratio IC50	=	42					0	BAO_0000179			630933	CHEMBL1116532	B	Selectivity ratio of IC50 for human recombinant HDAC2 preincubated for 1 hr with substrate to IC50 for human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			51178	CHEMBL1158590	20392638	Bioorg. Med. Chem. Lett.	2010	20	10	3142			
CHEMBL1091474	614515	CHEMBL1091474	614515		4b	425.46	3.92	109.14	0	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)c2cn(nn2)c3ccc(F)cc3	3201407	IC50	=	60	nM	7.22			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	616013	CHEMBL1101057	B	Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			50398	CHEMBL1154884	20055418	J. Med. Chem.	2010	53	3	1347			
CHEMBL519668	508340	CHEMBL519668	508340		4a	407.47	3.71	109.14	0	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)c2cn(nn2)c3ccccc3	3201408	IC50	=	63.9	nM	7.19			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	616013	CHEMBL1101057	B	Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			50398	CHEMBL1154884	20055418	J. Med. Chem.	2010	53	3	1347			
CHEMBL1091815	614581	CHEMBL1091815	614581		4e	443.45	4.12	109.14	0	ONC(=O)CCCCCCC(=O)Nc1cccc(c1)c2cn(nn2)c3cc(F)cc(F)c3	3201416	IC50					Not Determined		0	BAO_0000190			616013	CHEMBL1101057	B	Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			50398	CHEMBL1154884	20055418	J. Med. Chem.	2010	53	3	1347			
CHEMBL3286732	1757252	CHEMBL3286732	1757252		2	449.53	2.37	137.82	0	Nc1ccc(cc1NC(=O)c2ccc(nc2)N3CCC4(CC3)CNC(=O)O4)c5cccs5	14721742	IC50	=	45	nM	7.35			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1362739	CHEMBL3294938	B	Inhibition of FLAG-tagged full-length human recombinant HDAC2 expressed in baculovirus infected Sf9 cells using acetyl-lysine containing peptide as substrate preincubated for 10 mins followed by substrate addition measured after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	83736	CHEMBL3286368		ACS Med. Chem. Lett.	2014	5	4	340			
CHEMBL3286732	1757252	CHEMBL3286732	1757252		2	449.53	2.37	137.82	0	Nc1ccc(cc1NC(=O)c2ccc(nc2)N3CCC4(CC3)CNC(=O)O4)c5cccs5	14721764	Inhibition					tde		0	BAO_0000376			1362747	CHEMBL3294946	B	Time dependent inhibition of FLAG-tagged full-length human recombinant HDAC2 expressed in baculovirus infected Sf9 cells using acetyl-lysine containing peptide as substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			83736	CHEMBL3286368		ACS Med. Chem. Lett.	2014	5	4	340			
CHEMBL3286732	1757252	CHEMBL3286732	1757252		2	449.53	2.37	137.82	0	Nc1ccc(cc1NC(=O)c2ccc(nc2)N3CCC4(CC3)CNC(=O)O4)c5cccs5	14721766	Inhibition					Active		0	BAO_0000376			1362749	CHEMBL3295192	B	Competitive inhibition of FLAG-tagged full-length human recombinant HDAC2 expressed in baculovirus infected Sf9 cells using acetyl-lysine containing peptide as substrate preincubated for 10 mins followed by substrate addition measured after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			83736	CHEMBL3286368		ACS Med. Chem. Lett.	2014	5	4	340			
CHEMBL3286732	1757252	CHEMBL3286732	1757252		2	449.53	2.37	137.82	0	Nc1ccc(cc1NC(=O)c2ccc(nc2)N3CCC4(CC3)CNC(=O)O4)c5cccs5	14721768	Inhibition					Active		0	BAO_0000376			1362751	CHEMBL3295194	B	Reversible inhibition of FLAG-tagged full-length human recombinant HDAC2 expressed in baculovirus infected Sf9 cells using acetyl-lysine containing peptide as substrate preincubated for 10 mins followed by substrate addition measured after 60 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			83736	CHEMBL3286368		ACS Med. Chem. Lett.	2014	5	4	340			
CHEMBL3526396	1924092	CHEMBL3526396	1924092		M2	349.43	1.95	78.59	0	C[C@@]12Nc3ccccc3[C@]1(O)CCN2Cc4ccc(\C=C\C(=O)N)cc4	15470275	IC50	=	6000	nM	5.22			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1484269	CHEMBL3538485	B	Inhibition of flag-tagged HDAC2 (unknown origin) expressed in SF21 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation counting	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91925	CHEMBL3526051	22344701	Drug Metab. Dispos.	2012	40	5	1041			
CHEMBL3417214	1840422	CHEMBL3417214	1840422		11b	663.78	5.55	149.38	2	COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NCc4ccc(cc4)C(=O)Nc5cc(ccc5N)c6cccs6	15218884	IC50	=	270	nM	6.57			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1471124	CHEMBL3421014	B	Inhibition of recombinant human HDAC2 expressed in baculovirus infected insect High5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91571	CHEMBL3414494	25805446	Eur. J. Med. Chem.	2015	95		127			
CHEMBL3417213	1840421	CHEMBL3417213	1840421		11a	581.66	4.08	121.14	1	COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NCc4ccc(cc4)C(=O)Nc5ccccc5N	15218900	IC50	=	6730	nM	5.17			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1471124	CHEMBL3421014	B	Inhibition of recombinant human HDAC2 expressed in baculovirus infected insect High5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91571	CHEMBL3414494	25805446	Eur. J. Med. Chem.	2015	95		127			
CHEMBL3417210	1840418	CHEMBL3417210	1840418		6b	677.77	5.22	166.45	2	COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(=O)c4ccc(cc4)C(=O)Nc5cc(ccc5N)c6cccs6	15218911	IC50	=	380	nM	6.42			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1471124	CHEMBL3421014	B	Inhibition of recombinant human HDAC2 expressed in baculovirus infected insect High5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91571	CHEMBL3414494	25805446	Eur. J. Med. Chem.	2015	95		127			
CHEMBL3421737	1841173	CHEMBL3421737	1841173		10a	399.45	2.57	106.07	0	Nc1ccccc1NC(=O)c2ccc(CNCc3onc(n3)c4ccccc4)cc2	15234966	IC50	=	530	nM	6.28			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL3421739	1841175	CHEMBL3421739	1841175		10c	429.47	2.56	115.3	0	COc1ccc(cc1)c2noc(CNCc3ccc(cc3)C(=O)Nc4ccccc4N)n2	15234968	IC50	=	290	nM	6.54			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL3421742	1841178	CHEMBL3421742	1841178		10f	444.44	2.47	151.88	0	Nc1ccccc1NC(=O)c2ccc(CNCc3onc(n3)c4ccc(cc4)[N+](=O)[O-])cc2	15234971	IC50	=	150	nM	6.82			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL3421743	1841179	CHEMBL3421743	1841179		10g	417.44	2.78	106.07	0	Nc1ccccc1NC(=O)c2ccc(CNCc3onc(n3)c4ccc(F)cc4)cc2	15234972	IC50	=	280	nM	6.55			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL3421744	1841180	CHEMBL3421744	1841180		10h	405.47	2.53	134.31	0	Nc1ccccc1NC(=O)c2ccc(CNCc3onc(n3)c4cccs4)cc2	15234973	IC50	=	4390	nM	5.36			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL3421745	1841181	CHEMBL3421745	1841181		10i	400.43	1.42	118.96	0	Nc1ccccc1NC(=O)c2ccc(CNCc3onc(n3)c4cccnc4)cc2	15234974	IC50	=	8370	nM	5.08			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL3421747	1841183	CHEMBL3421747	1841183		11a	324.33	1.55	100.28	0	ONC(=O)c1ccc(CNCc2onc(n2)c3ccccc3)cc1	15234976	IC50	>	10000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL3421752	1841188	CHEMBL3421752	1841188		11f	369.33	1.44	146.1	0	ONC(=O)c1ccc(CNCc2onc(n2)c3ccc(cc3)[N+](=O)[O-])cc1	15234981	IC50	=	9230	nM	5.03			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA, Zolinza	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	15234984	IC50	=	280	nM	6.55			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1475364	CHEMBL3425297	B	Inhibition of recombinant HDAC2 (unknown origin) using fluorogenic substrate Boc-Lys (acetyl)-AMC after 20 mins by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91680	CHEMBL3421568	25874326	Eur. J. Med. Chem.	2015	96		1			
CHEMBL3526395	1924091	CHEMBL3526395	1924091		M1	365.43	1.96	84.83	0	C[C@@]12Nc3ccccc3[C@]1(O)CCN2Cc4ccc(\C=C\C(=O)NO)cc4	15470296	IC50	=	1500	nM	5.82			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1484269	CHEMBL3538485	B	Inhibition of flag-tagged HDAC2 (unknown origin) expressed in SF21 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation counting	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91925	CHEMBL3526051	22344701	Drug Metab. Dispos.	2012	40	5	1041			
CHEMBL2431901	1583962	CHEMBL2431901	1583962		2	299.32	1.51	74.57	0	Cn1cccc1C(=O)N2CCc3cc(ccc3C2)C(=O)NO	14992234	IC50	>	50000	nM				1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1431996	CHEMBL3388101	B	Inhibition of full length C-terminal 6x-His tagged human HDAC2 using Arg-His-Lys-Lys(Ac) substrate incubated for 2 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			89845	CHEMBL3351349	25454270	Bioorg. Med. Chem. Lett.	2014	24	23	5450			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA, Vorinostat, Zolinza	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	14992235	IC50	=	164	nM	6.79			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1431996	CHEMBL3388101	B	Inhibition of full length C-terminal 6x-His tagged human HDAC2 using Arg-His-Lys-Lys(Ac) substrate incubated for 2 hrs by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89845	CHEMBL3351349	25454270	Bioorg. Med. Chem. Lett.	2014	24	23	5450			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	1, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	14976172	IC50	=	921	nM	6.04			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1444620	CHEMBL3376039	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90082	CHEMBL3352629	25563890	Bioorg. Med. Chem. Lett.	2015	25	3	459			
CHEMBL3356922	1821065	CHEMBL3356922	1821065		86, ST8084	377.5	2.07	126.1	0	Cc1cccc(NC(=O)[C@H](CCCCCS)NC(=O)[C@@H]2CCC(=O)N2)c1	15138233	IC50	=	13	nM	7.89			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3356921	1821064	CHEMBL3356921	1821064		83, ST8080	377.5	1.79	117.31	0	CN1[C@H](CCC1=O)C(=O)N[C@@H](CCCCCS)C(=O)Nc2ccccc2	15138234	IC50	=	103	nM	6.99			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL109654	184613	CHEMBL109654	184613		146, ST7660	223.33	2.73	67.9	0	SCCCCCC(=O)Nc1ccccc1	15138246	IC50	=	2220	nM	5.65			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	1, SAHA, Zolinza, Vorinostat	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	15138248	IC50	=	921	nM	6.04			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3356929	1821072	CHEMBL3356929	1821072		80, ST7897	349.45	1.26	126.1	0	SCCCCC[C@H](NC(=O)[C@@H]1CC(=O)N1)C(=O)Nc2ccccc2	15138284	IC50	=	68	nM	7.17			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3356935	1821078	CHEMBL3356935	1821078		132, ST7894	497.65	3.61	135.33	0	SCCCCC[C@H](NC(=O)[C@@H]1CCCC(=O)N1)C(=O)NCc2cccc(OCc3ccccc3)c2	15138290	IC50	=	2540	nM	5.6			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3356937	1821080	CHEMBL3356937	1821080		84, ST7899	419.58	2.85	126.1	0	Cc1cccc(CCNC(=O)[C@H](CCCCCS)NC(=O)[C@@H]2CCCC(=O)N2)c1	15138292	IC50	=	601	nM	6.22			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1443001	CHEMBL3379479	B	Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89379	CHEMBL3352570	25233084	J. Med. Chem.	2014	57	20	8358			
CHEMBL3352990	1817093	CHEMBL3352990	1817093		6a	500.59	1.48	153.69	1	CC(C)[C@H]1NC(=O)C[C@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O)\C=C\CCCC(=O)O	15126322	Ki	=	1700	nM	5.77			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	1440125	CHEMBL3382538	B	Inhibition of human recombinant HDAC2 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89689	CHEMBL3351463	25380299	J. Med. Chem.	2014	57	22	9644			
CHEMBL3352991	1817094	CHEMBL3352991	1817094		6b	516.59	1.24	173.92	2	CC(C)[C@H]1NC(=O)C[C@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)NC1=O)\C=C\CCCC(=O)O	15126323	Ki	=	600	nM	6.22			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	1440125	CHEMBL3382538	B	Inhibition of human recombinant HDAC2 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89689	CHEMBL3351463	25380299	J. Med. Chem.	2014	57	22	9644			
CHEMBL3352823	1817100	CHEMBL3352823	1817100		9b	516.59	1.1	173.92	2	CC(C)[C@H]1NC(=O)C[C@@H](C\C=C/CCC(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)NC1=O	15126329	Ki	=	300	nM	6.52			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	1440125	CHEMBL3382538	B	Inhibition of human recombinant HDAC2 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89689	CHEMBL3351463	25380299	J. Med. Chem.	2014	57	22	9644			
CHEMBL3352997	1817101	CHEMBL3352997	1817101		9c	539.62	1.64	169.48	2	CC(C)[C@H]1NC(=O)C[C@@H](C\C=C/CCC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](C)NC1=O	15126330	Ki	=	300	nM	6.52			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	1440125	CHEMBL3382538	B	Inhibition of human recombinant HDAC2 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89689	CHEMBL3351463	25380299	J. Med. Chem.	2014	57	22	9644			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA, Vorinostat	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	15053551	IC50	=	28	nM	7.55			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1450057	CHEMBL3373319	B	Inhibition of human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90190	CHEMBL3351757	24864038	Bioorg. Med. Chem.	2014	22	14	3720			
CHEMBL3311473	1780583	CHEMBL3311473	1780583		21	361.44	1.75	107.53	0	CC1(C)CC(=O)Nc2ccc(cc12)C(=O)NCCCCCCC(=O)NO	15053557	IC50	=	93	nM	7.03			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1450057	CHEMBL3373319	B	Inhibition of human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90190	CHEMBL3351757	24864038	Bioorg. Med. Chem.	2014	22	14	3720			
CHEMBL3309288	1778376	CHEMBL3309288	1778376		31	345.39	2.55	100.55	0	COc1ccc2cc(ccc2n1)C(=O)NCCCCCCC(=O)NO	15053560	IC50	=	170	nM	6.77			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1450057	CHEMBL3373319	B	Inhibition of human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90190	CHEMBL3351757	24864038	Bioorg. Med. Chem.	2014	22	14	3720			
CHEMBL3309290	1778378	CHEMBL3309290	1778378		33	393.44	2.01	107.52	0	CC1(C)CC(=O)Nc2ccc(cc12)C(=O)NCc3cccc(\C=C\C(=O)NO)c3	15053561	IC50	=	100	nM	7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1450057	CHEMBL3373319	B	Inhibition of human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90190	CHEMBL3351757	24864038	Bioorg. Med. Chem.	2014	22	14	3720			
CHEMBL3309291	1778379	CHEMBL3309291	1778379		34	393.44	2.01	107.53	0	CC1(C)CC(=O)Nc2ccc(cc12)C(=O)NCc3ccc(\C=C\C(=O)NO)cc3	15053562	IC50	=	22	nM	7.66			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1450057	CHEMBL3373319	B	Inhibition of human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90190	CHEMBL3351757	24864038	Bioorg. Med. Chem.	2014	22	14	3720			
CHEMBL3309298	1778386	CHEMBL3309298	1778386		41	401.5	2.4	107.52	0	CC1(C)CC(=O)Nc2ccc(cc12)C(=O)NC[C@@H]3CC[C@@H](CCC(=O)NO)CC3	15053564	IC50	=	35	nM	7.46			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1450057	CHEMBL3373319	B	Inhibition of human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90190	CHEMBL3351757	24864038	Bioorg. Med. Chem.	2014	22	14	3720			
CHEMBL3317813	1782452	CHEMBL3317813	1782452		6	512.62	.79	239.38	1	C[C@@]12CSC(=N1)c3csc(CNC(=O)C[C@H](OC(=O)[C@H](CC(=O)O)NC2=O)\C=C\CCS)n3	15060216	IC50	=	150	nM	6.82			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1452234	CHEMBL3366146	B	Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90621	CHEMBL3352389	25070421	Bioorg. Med. Chem. Lett.	2014	24	16	3728			
CHEMBL3317810	1782449	CHEMBL3317810	1782449		3	544.71	2.97	202.08	1	C[C@@]12CSC(=N1)c3csc(CNC(=O)C[C@H](OC(=O)[C@H](Cc4ccccc4)NC2=O)\C=C\CCS)n3	15060219	IC50	=	1.7	nM	8.77			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1452234	CHEMBL3366146	B	Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90621	CHEMBL3352389	25070421	Bioorg. Med. Chem. Lett.	2014	24	16	3728			
CHEMBL3317817	1782456	CHEMBL3317817	1782456		10	611.8	2.47	240.41	1	CC(C)(C)OC(=O)NCCC[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c3csc(CNC(=O)C[C@H](OC1=O)\C=C\CCS)n3	15060233	IC50	=	1.4	nM	8.85			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1452234	CHEMBL3366146	B	Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90621	CHEMBL3352389	25070421	Bioorg. Med. Chem. Lett.	2014	24	16	3728			
CHEMBL3353925	1818038	CHEMBL3353925	1818038		2	363.47	1.58	126.1	0	SCCCCC[C@H](NC(=O)[C@H]1CCC(=O)N1)C(=O)Nc2ccccc2	14976173	IC50	=	78	nM	7.11			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1444620	CHEMBL3376039	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90082	CHEMBL3352629	25563890	Bioorg. Med. Chem. Lett.	2015	25	3	459			
CHEMBL3353927	1818040	CHEMBL3353927	1818040		4	431.47	2.53	126.1	0	FC(F)(F)c1cccc(NC(=O)[C@H](CCCCCS)NC(=O)[C@H]2CCC(=O)N2)c1	14976174	IC50	=	12	nM	7.92			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1444620	CHEMBL3376039	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90082	CHEMBL3352629	25563890	Bioorg. Med. Chem. Lett.	2015	25	3	459			
CHEMBL3329621	1788609	CHEMBL3329621	1788609		4	991.32	4.66	377.18	2	CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c3csc(CNC(=O)C[C@H](OC1=O)\C=C\CCSSCC\C=C\[C@@H]4CC(=O)NCc5nc(cs5)C6=N[C@@](C)(CS6)C(=O)N[C@@H](C(C)C)C(=O)O4)n3	15136620	IC50	=	.5	nM	9.3			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1455096	CHEMBL3366352	B	Inhibition of HDAC2 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90823	CHEMBL3352121	25147612	ACS Med. Chem. Lett.	2014	5	8	905			
CHEMBL199974	335473	CHEMBL199974	335473		33	238.24	2.89	46.53	0	Oc1ccc(\C=C\2/Oc3ccccc3C2=O)cc1	14973539	IC50	=	100500	nM			Outside typical range	0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1434457	CHEMBL3388274	B	Inhibition of HDAC2 (unknown origin) after 15 mins by fluorescence assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89860	CHEMBL3352210	25455492	Bioorg. Med. Chem. Lett.	2014	24	23	5497			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	vorinostat, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	15076858	IC50	=	182	nM	6.74			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1433878	CHEMBL3388839	B	Inhibition of human recombinant HDAC2 after 60 mins by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		89339	CHEMBL3352093	25218912	Eur. J. Med. Chem.	2014	86		639			
CHEMBL152543	256088	CHEMBL152543	256088		19b, SK-7068	365.43	2.73	81.67	0	ONC(=O)\C=C\c1ccc(CNC(=O)c2ccc(cc2)N3CCCC3)cc1	2106233	Inhibition	>	90	%				0	BAO_0000201	UO_0000187	http://qudt.org/vocab/unit#Percent	464972	CHEMBL947144	B	Inhibition of HDAC2 at 1 uM	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38494	CHEMBL1142268	18247554	J. Med. Chem.	2008	51	6	1505			
CHEMBL403323	439264	CHEMBL403323	439264		1n	379.45	3.05	88.59	0	OCCN(CCc1cc2ccccc2[nH]1)Cc3ccc(\C=C\C(=O)NO)cc3	2106258	IC50					Not Determined		0	BAO_0000190			464924	CHEMBL946981	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38494	CHEMBL1142268	18247554	J. Med. Chem.	2008	51	6	1505			
CHEMBL481726	474789	CHEMBL481726	474789		12c	359.4	.63	126.98	0	ONC(=O)c1ccc(CN2[C@H](Cc3cccs3)C(=O)NCC2=O)cc1	2489486	IC50	=	3470	nM	5.46			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	515266	CHEMBL991290	B	Inhibition of human recombinant histone deacetylase 2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45582	CHEMBL1143301	19111466	Bioorg. Med. Chem. Lett.	2009	19	3	688			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	2657742	IC50	=	100	nM	7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	1	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	2623802	IC50	=	82	nM	7.09			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	522846	CHEMBL1002514	B	Inhibition of human C-terminal FLAG-tagged HDAC2 in HEK293 cells	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	46750	CHEMBL1136937	19441846	J. Med. Chem.	2009	52	11	3453	722	CHEMBL3307715	HEK293
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	1a, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	3201449	IC50	=	282	nM	6.55			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	616013	CHEMBL1101057	B	Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			50398	CHEMBL1154884	20055418	J. Med. Chem.	2010	53	3	1347			
CHEMBL1213457	685301	CHEMBL1213457	685301		22	357.32	1.44	151.47	1	ONC(=O)\C=C\c1ccc(cc1)C(=O)N\N=C\c2ccc(O)c(O)c2O	3389906	Ki	=	70	nM	7.15			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	646842	CHEMBL1216983	B	Inhibition of human HDAC2	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	52156	CHEMBL1212811	20139990	Nat. Chem. Biol.	2010	6	3	238			
CHEMBL430060	275631	CHEMBL430060	275631	APICIDIN	Apicidin	623.78	1.58	138.84	1	CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cn(OC)c3ccccc23)NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]4CCCCN4C1=O	3329005	IC50	=	1	nM	9			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	639057	CHEMBL1166310	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51553	CHEMBL1165952	20472442	Bioorg. Med. Chem.	2010	18	11	4103			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	3437997	IC50	=	390	nM	6.41			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	658913	CHEMBL1246052	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			52747	CHEMBL1240475	20637529	Eur. J. Med. Chem.	2010	45	9	4331			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	3328985	IC50	=	36	nM	7.44			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	639057	CHEMBL1166310	B	Inhibition of HDAC2	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			51553	CHEMBL1165952	20472442	Bioorg. Med. Chem.	2010	18	11	4103			
CHEMBL1631917	1054909	CHEMBL1631917	1054909		(S)-10	456.53	3.71	106.11	0	COc1cc2CCCO[C@@H](CCCCCC(=O)NO)C(=O)Nc3ccccc3OCc(c2)c1	5090675	IC50	=	268	nM	6.57			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	690171	CHEMBL1634301	B	Inhibition of human HDAC2 by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	54338	CHEMBL1629537	21073160	J. Med. Chem.	2010	53	23	8387			
CHEMBL1643325	1057883	CHEMBL1643325	1057883		5aj	613.79	6.04	99.49	2	Nc1ccccc1NC(=O)\C=C\c2ccc(cc2)C(NCCN3CCCCC3)C(=O)Nc4ccc(cc4)c5ccc(cc5)C6CC6	5122780	IC50	=	240	nM	6.62			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	700124	CHEMBL1647006	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			54702	CHEMBL1641604	21145737	Bioorg. Med. Chem. Lett.	2011	21	1	110			
CHEMBL2022833	1338206	CHEMBL2022833	1338206		12	574.75	8.12	128.12	2	O=C(N[C@@H](CCCCCCSSc1ccccn1)C(=O)OCc2cccc3ccccc23)OCc4ccccc4	10862551	IC50	=	39.6	nM	7.4			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	816365	CHEMBL2024763	B	Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	61731	CHEMBL2021837	22465091	Eur. J. Med. Chem.	2012	52		111			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	6182571	IC50	=	66	nM	7.18			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	744275	CHEMBL1772082	B	Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			57403	CHEMBL1770095	21334896	Bioorg. Med. Chem. Lett.	2011	21	9	2601			
CHEMBL1800250	1161313	CHEMBL1800250	1161313		16	260.31	2.95	88.38	0	Cc1cc(O)nc(SCC(=O)c2ccccc2)n1	6283039	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL1631913	1054905	CHEMBL1631913	1054905		(R/S)-9	454.52	3.4	106.11	0	COc1cc2COc3ccccc3NC(=O)C(CCCCCC(=O)NO)OC\C=C/c(c2)c1	5090671	IC50	=	207	nM	6.68			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	690171	CHEMBL1634301	B	Inhibition of human HDAC2 by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	54338	CHEMBL1629537	21073160	J. Med. Chem.	2010	53	23	8387			
CHEMBL98	11305	CHEMBL98	11305	VORINOSTAT	1, SAHA	264.32	2.01	78.43	0	ONC(=O)CCCCCCC(=O)Nc1ccccc1	6174064	IC50	=	240	nM	6.62			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL1767046	1142085	CHEMBL1767046	1142085		41	440.54	3.06	112.05	0	CNC(=O)\C(=N/O)\CCCCC[C@H](NCc1ccc(OC)cc1)C(=O)Nc2ccccc2	6174082	IC50	=	95900	nM	4.02			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL1834365	1178409	CHEMBL1834365	1178409		TM-2-138	274.31	3.97	73.22	0	Fc1ccccc1C(=O)NC(=S)Nc2ccccc2	6376224	Inhibition					Not Active		0	BAO_0000376			771822	CHEMBL1838694	B	Inhibition of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1834365	1178409	CHEMBL1834365	1178409		TM-2-138	274.31	3.97	73.22	0	Fc1ccccc1C(=O)NC(=S)Nc2ccccc2	6377072	Activity					Not Active		0	BAO_0000375			771836	CHEMBL1838708	B	Activation of HDAC2 using Fluor-de-Lys as substrate at 10 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL1834365	1178409	CHEMBL1834365	1178409		TM-2-138	274.31	3.97	73.22	0	Fc1ccccc1C(=O)NC(=S)Nc2ccccc2	6376312	Activity					Not Active		0	BAO_0000375			771829	CHEMBL1838701	B	Activation of HDAC2 using Fluor-de-Lys as substrate at 100 uM by spectrofluorometry	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			59110	CHEMBL1833857	21865040	Bioorg. Med. Chem. Lett.	2011	21	19	5920			
CHEMBL99	11501	CHEMBL99	11501	TRICHOSTATIN	TSA	302.37	2.77	69.63	0	C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C	7921741	IC50	=	68	nM	7.17			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	785884	CHEMBL1921153	B	Inhibition of human recombinant HDAC2 using fluorophore-conjugated substrate Boc-L-Lys(Ac)-AMC after 60 mins	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	60081	CHEMBL1914352	21548582	J. Med. Chem.	2011	54	13	4350			
CHEMBL27759	36237	CHEMBL27759	36237	ENTINOSTAT	MS-275	376.41	2.07	106.33	0	Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2	8048590	IC50	=	1510	nM	5.82			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	807676	CHEMBL1959441	B	Inhibition of HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			61262	CHEMBL1955769	22321215	Bioorg. Med. Chem. Lett.	2012	22	5	1926			
CHEMBL27759	36237	CHEMBL27759	36237	ENTINOSTAT	MS-275	376.41	2.07	106.33	0	Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2	8048604	Inhibition					Active		0	BAO_0000376			807673	CHEMBL1959438	B	Inhibition of HDAC2 in human HCT116 cells assessed as hyperacetylation of histone H3 at 10 uM after 24 hrs by Western blot analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			61262	CHEMBL1955769	22321215	Bioorg. Med. Chem. Lett.	2012	22	5	1926			
CHEMBL1958439	1283980	CHEMBL1958439	1283980		18	348.37	1.78	113.11	0	COc1ccc(NS(=O)(=O)c2cccc(\C=C\C(=O)NO)c2)cc1	8054623	ED50	=	105	nM			Non standard unit for type	0	BAO_0003036	UO_0000065	http://www.openphacts.org/units/Nanomolar	808465	CHEMBL1961041	B	Inhibition of human recombinant HDAC2 expressed using baculovirus expression system using Flour- De-Lys as substrate after 3 hrs by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			61278	CHEMBL1955831	22326398	Bioorg. Med. Chem. Lett.	2012	22	5	1886			
CHEMBL356769	239841	CHEMBL356769	239841	TUBACIN	Tubacin	721.86	7.18	168.45	2	OCc1ccc(cc1)[C@@H]2C[C@H](CSc3oc(c4ccccc4)c(n3)c5ccccc5)O[C@@H](O2)c6ccc(NC(=O)CCCCCCC(=O)NO)cc6	13467516	IC50	=	6270	nM	5.2			1	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	984752	CHEMBL2432126	B	Inhibition of human recombinant HDAC2 using RHKKAc as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	75006	CHEMBL2429834	23964961	J. Med. Chem.	2013	56	18	7201			
CHEMBL2407718	1572124	CHEMBL2407718	1572124		24b	402.51	3.89	104.81	0	Nc1ccccc1NC(=O)c2ccc(CNC3=N[C@@H](CS3)c4ccccc4)cc2	13395007	IC50	=	56	nM	7.25			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL356769	239841	CHEMBL356769	239841	TUBACIN	tubacin	721.86	7.18	168.45	2	OCc1ccc(cc1)[C@@H]2C[C@H](CSc3oc(c4ccccc4)c(n3)c5ccccc5)O[C@@H](O2)c6ccc(NC(=O)CCCCCCC(=O)NO)cc6	13431423	IC50	=	6270	nM	5.2			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	977771	CHEMBL2420992	B	Inhibition of human recombinant HDAC2 protein using RHKKAc from p53 as substrate	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74749	CHEMBL2417402	23627282	J. Med. Chem.	2013	56	16	6297			
CHEMBL2408241	1572652	CHEMBL2408241	1572652		4e	288.3	2.17	64.99	0	COc1ccc(C2=CC=CC=C(O)C2=O)c(OC)c1OC	13393218	Ki	=	.23	nM	9.64			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	972539	CHEMBL2410191	B	Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74297	CHEMBL2407068		ACS Med. Chem. Lett.	2013	4	8	757			
CHEMBL564876	564493	CHEMBL564876	564493		4d, ST2741	375.46	5.03	80.91	1	ONC(=O)CCCCCC(c1c[nH]c2ccccc12)c3c[nH]c4ccccc34	2720672	IC50	=	2000	nM	5.7			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	585885	CHEMBL1053556	B	Inhibition of human HDAC2 by fluorimetry	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	48183	CHEMBL1153591	19359173	Bioorg. Med. Chem. Lett.	2009	19	10	2840			
CHEMBL2047605	1351029	CHEMBL2047605	1351029		5a	379.45	5.74	46.92	1	Cc1ccc(cc1)c2nn(cc2\C=C/C(=O)Nc3ccccc3)c4ccccc4	10947972	IC50	=	8750	nM	5.06			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	827843	CHEMBL2051252	B	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62524	CHEMBL2046430	22705022	Bioorg. Med. Chem.	2012	20	14	4430			
CHEMBL2407720	1572126	CHEMBL2407720	1572126		24d	416.54	4.21	104.81	0	Nc1ccccc1NC(=O)c2ccc(CNC3=N[C@@H](Cc4ccccc4)CS3)cc2	13395005	IC50	=	104	nM	6.98			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	973951	CHEMBL2410098	B	Inhibition of recombinant His-tagged HDAC2 (1 to 488) (unknown origin) using MAL as substrate incubated for 3 hrs prior to substrate addition measured after 60 mins by fluorescence plate reader analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74396	CHEMBL2407081	23829483	J. Med. Chem.	2013	56	15	6156			
CHEMBL3426804	1844190	CHEMBL3426804	1844190		2, MC2625	387.43	3.36	91.32	0	ONC(=O)\C=C\c1ccc(NC(=O)C(Cc2ccccc2)c3ccccc3)cn1	15248544	IC50	=	1770	nM	5.75			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1478435	CHEMBL3429373	B	Inhibition of recombinant HDAC2 (unknown origin) by homogeneous fluorescence release assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		91811	CHEMBL3425488	25905694	J. Med. Chem.	2015	58	9	4073			
CHEMBL3311465	1780575	CHEMBL3311465	1780575		13	333.38	1.45	107.53	0	ONC(=O)CCCCCCC(=O)Nc1ccc2NC(=O)CCc2c1	15053553	IC50	=	18	nM	7.74			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1450057	CHEMBL3373319	B	Inhibition of human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl		90190	CHEMBL3351757	24864038	Bioorg. Med. Chem.	2014	22	14	3720			
CHEMBL471824	516933	CHEMBL471824	516933		11	427.54	2.95	83.28	0	Nc1ccc(cc1NC(=O)c2ccc(nc2)N3CCC4(CCNC4)CC3)c5ccccc5	2380645	IC50	=	110	nM	6.96			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	493107	CHEMBL940370	B	Inhibition of human HDAC2 expressed in mammalian cells	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	45872	CHEMBL1152282	18951790	Bioorg. Med. Chem. Lett.	2008	18	23	6104			
CHEMBL556532	559430	CHEMBL556532	559430		1	239.27	2.83	49.33	0	ONC(=O)\C=C\c1ccc(cc1)c2ccccc2	2657767	IC50	=	820	nM	6.09			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL1631910	1054902	CHEMBL1631910	1054902		(R/S)-8a	364.44	2.53	96.89	0	ONC(=O)CCCCCC1OCCCCCOc2ccccc2NC1=O	5090668	IC50	=	1930	nM	5.71			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	690171	CHEMBL1634301	B	Inhibition of human HDAC2 by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	54338	CHEMBL1629537	21073160	J. Med. Chem.	2010	53	23	8387			
CHEMBL1767034	1142073	CHEMBL1767034	1142073		18	381.47	3.66	90.79	0	CNC(=O)\C(=N/O)\CCCCCCC(=O)Nc1ccc(cc1)c2ccccc2	6174070	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL1767039	1142078	CHEMBL1767039	1142078		23	416.9	3.38	103.68	0	CNC(=O)\C(=N/O)\CCCCCCC(=O)Nc1cccc(c1)c2ccc(Cl)nc2	6174075	IC50	=	69700	nM	4.16			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	743697	CHEMBL1767466	B	Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	57316	CHEMBL1765034	21417297	J. Med. Chem.	2011	54	7	2165			
CHEMBL1800245	1161308	CHEMBL1800245	1161308		11	301.36	2.51	91.7	0	CC(=O)Nc1ccc(cc1)C(=O)CSc2cccc(O)c2	6283034	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	757634	CHEMBL1804891	B	Inhibition of recombinant HDAC2 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58268	CHEMBL1800036	21696956	Bioorg. Med. Chem. Lett.	2011	21	14	4164			
CHEMBL2022827	1338199	CHEMBL2022827	1338199		5	585.78	8.07	130.92	2	O=C(N[C@@H](CCCCCCSSc1ccccn1)C(=O)Nc2ccc(cc2)c3ccccc3)OCc4ccccc4	10862530	IC50	=	46.6	nM	7.33			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	816365	CHEMBL2024763	B	Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	61731	CHEMBL2021837	22465091	Eur. J. Med. Chem.	2012	52		111			
CHEMBL2022832	1338205	CHEMBL2022832	1338205		11	574.75	8.12	128.12	2	O=C(N[C@@H](CCCCCCSSc1ccccn1)C(=O)OCc2ccc3ccccc3c2)OCc4ccccc4	10862548	IC50	=	40.3	nM	7.39			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	816365	CHEMBL2024763	B	Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	61731	CHEMBL2021837	22465091	Eur. J. Med. Chem.	2012	52		111			
CHEMBL2047608	1351032	CHEMBL2047608	1351032		5d	409.48	5.73	56.15	1	COc1ccc(NC(=O)\C=C/c2cn(nc2c3ccc(C)cc3)c4ccccc4)cc1	10947975	IC50	=	6450	nM	5.19			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	827843	CHEMBL2051252	B	Inhibition of HDAC2 in human HeLa cell lysate using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	62524	CHEMBL2046430	22705022	Bioorg. Med. Chem.	2012	20	14	4430			
CHEMBL2408238	1572649	CHEMBL2408238	1572649		4b	248.28	3.13	37.29	0	OC1=CC=CC=C(C1=O)c2ccc3ccccc3c2	13393217	Ki	=	.25	nM	9.6			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	972539	CHEMBL2410191	B	Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	74297	CHEMBL2407068		ACS Med. Chem. Lett.	2013	4	8	757			
CHEMBL3110287	1615495	CHEMBL3110287	1615495		10d	340.44	3.64	86.27	0	OC1=CC=CN(CCCCCn2cc(nn2)c3ccccc3)C1=S	13890344	IC50	=	5840	nM	5.23			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1286645	CHEMBL3111120	B	Inhibition of HDAC2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using GRKacYGC as substrate after 60 mins by SAMDI mass spectrometric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000019	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76678	CHEMBL3108745	24304348	J. Med. Chem.	2013	56	24	9969			
CHEMBL3098688	1609459	CHEMBL3098688	1609459		17	418.49	.73	136.63	0	ONC(=O)CCCCC[C@H](NC(=O)[C@H]1CCC(=O)N1)C(=O)NCCc2ccccc2	13867795	IC50	=	180	nM	6.74			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL3098604	1609374	CHEMBL3098604	1609374		29	404.46	.89	136.63	0	Cc1cccc(NC(=O)[C@H](CCCCCC(=O)NO)NC(=O)[C@H]2CCC(=O)N2)c1	13867800	IC50	=	27	nM	7.57			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1282240	CHEMBL3102465	B	Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein	Hist_deacetyl	medium	76432	CHEMBL3098008	24345446	Bioorg. Med. Chem. Lett.	2014	24	1	61			
CHEMBL538364	554220	CHEMBL538364	554220		1d	295.33	3.28	58.56	0	COc1ccc(cc1)c2ccc(\C=C\C=C\C(=O)NO)cc2	14570886	IC50	>	5000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	1335247	CHEMBL3238600	B	Inhibition of HDAC2 in human HeLa cells using KI-104 as substrate after 40 mins by fluorescence analysis	1	Scientific Literature	Homo sapiens		9606	Autocuration	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			82343	CHEMBL3232764	24742384	Eur. J. Med. Chem.	2014	79		251			
CHEMBL467792	488394	CHEMBL467792	488394		8	418.44	2.32	142.79	0	CC(C)(C)OC(=O)Nc1ccc(cc1)c2onc(c2)C(=O)NCCCCC(=O)NO	2569573	IC50	=	1740	nM	5.76			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	514670	CHEMBL976442	B	Inhibition of HDAC2 after 17 hrs	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			44070	CHEMBL1155917	18642892	J. Med. Chem.	2008	51	15	4370			
CHEMBL138293	232381	CHEMBL138293	232381		TWZ 101	264.32	1.5	69.64	0	CC(=O)N(O)CCCCCC(=O)Nc1ccccc1	1266083	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	87875	CHEMBL697297	B	Inhibition of Histone deacetylase 2 (HDAC2) activity of HeLa nuclear extracts	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			6553	CHEMBL1137945	14698179	Bioorg. Med. Chem. Lett.	2004	14	2	449			
CHEMBL138090	232406	CHEMBL138090	232406		TWZ 106	294.35	2.6	78.87	0	COC(=O)N(O)CCCCCCC(=O)Nc1ccccc1	1297741	IC50	>	100000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	87875	CHEMBL697297	B	Inhibition of Histone deacetylase 2 (HDAC2) activity of HeLa nuclear extracts	1	Scientific Literature	Homo sapiens		9606	Expert	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			6553	CHEMBL1137945	14698179	Bioorg. Med. Chem. Lett.	2004	14	2	449			
CHEMBL401751	436348	CHEMBL401751	436348		25	579.7	4.39	142.35	1	Nc1ccccc1NC(=O)c2ccc(CNc3nc(NCCN4CCOCC4)nc(NC5Cc6ccccc6C5)n3)cc2	2097987	Activity					Active		0	BAO_0000375			468079	CHEMBL931663	B	Activity against HDAC2	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			38730	CHEMBL1143113	18160287	Bioorg. Med. Chem. Lett.	2008	18	3	1067			
CHEMBL468595	488317	CHEMBL468595	488317		5	346.38	1.79	130.47	0	Nc1cccc(c1)c2onc(c2)C(=O)NCCCCCCC(=O)NO	2569576	IC50	=	56.7	nM	7.25			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	514670	CHEMBL976442	B	Inhibition of HDAC2 after 17 hrs	1	Scientific Literature				Intermediate	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			44070	CHEMBL1155917	18642892	J. Med. Chem.	2008	51	15	4370			
CHEMBL554573	557689	CHEMBL554573	557689		3e	240.26	1.68	62.22	0	ONC(=O)\C=C\c1ccc(cc1)c2ccncc2	2658571	IC50	>	5000	nM				0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	571846	CHEMBL1034714	B	Inhibition of HDAC2 in human HeLa cells	1	Scientific Literature	Homo sapiens		9606	Intermediate	BAO_0000219	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	9	Protein			47282	CHEMBL1158371	19084294	Eur. J. Med. Chem.	2009	44	5	1900	308	CHEMBL3308376	HeLa
CHEMBL1668018	1066559	CHEMBL1668018	1066559		10i	338.4	2.68	69.64	0	ONC(=O)CCC1=CCN(CCCc2ccc3ccccc3c2)C1=O	5198516	IC50	=	16400	nM	4.79			0	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	716691	CHEMBL1670516	B	Inhibition of HDAC2 by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			55411	CHEMBL1667837	21256006	Bioorg. Med. Chem. Lett.	2011	21	4	1218			
CHEMBL1830397	1177103	CHEMBL1830397	1177103		10f	386.53	3.93	70.39	0	CN(C)CC(C)(C)Cn1c(CC(C)(C)C)nc2cc(\C=C\C(=O)NO)ccc12	6370656	Ki	=	26	nM	7.59			0	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	769058	CHEMBL1832521	B	Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assay	1	Scientific Literature				Autocuration	BAO_0000357	11206	CHEMBL1937	SINGLE PROTEIN	Q92769	Histone deacetylase 2	Homo sapiens	8	Homologous protein			58940	CHEMBL1828590	21634430	J. Med. Chem.	2011	54	13	4694