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The subclonal fraction (fraction of tumor-derived DNA that is subclonal) is 0.446 but tumor fraction is 0 #121

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paulhtyang opened this issue Mar 25, 2023 · 0 comments
Open

The subclonal fraction (fraction of tumor-derived DNA that is subclonal) is 0.446 but tumor fraction is 0 #121

paulhtyang opened this issue Mar 25, 2023 · 0 comments

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@paulhtyang
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Hello,

I was trying to optimize the parameters of running ichorCNA so I got a genome-wide CNA plot showing "the subclonal fraction (fraction of tumor-derived DNA that is subclonal) is 0.446 although tumor fraction is 0". Please take a look at the figure below. I am wondering if I over-optimize the running.
image
Thanks
CT4-SynSarc1.params.txt
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@paulhtyang