From ed425e3c8d8e2ce579adcacd2d743da34fbcfc60 Mon Sep 17 00:00:00 2001
From: binzhangMIT <38547734+binzhangMIT@users.noreply.github.com>
Date: Thu, 29 Feb 2024 12:52:55 -0500
Subject: [PATCH] Update README.md

---
 tutorials/optimization/README.md | 6 ++++--
 1 file changed, 4 insertions(+), 2 deletions(-)

diff --git a/tutorials/optimization/README.md b/tutorials/optimization/README.md
index 59db1ee..cb20e7f 100644
--- a/tutorials/optimization/README.md
+++ b/tutorials/optimization/README.md
@@ -1,5 +1,7 @@
 ## Optimization code
 
-- chr_NL_optimization: optimization for the chromosome-nuclear landmarks interactions
+When developing the nucleus model, we optimized the interaction parameters between chromosomes and those between chromosome-nuclear landmarks separately. These optimizations make use of experimental data for HFF cells, and the resulting model is cell-type specific. When applying the model to a different cell type, one may consider reoptimizing the parameters with corresponding experimental data. The two folders here provide details on how to carry out parameter optimization.  
 
-- chr_chr_optimization: optimization for the chromosome-chromosome interactions
+- chr_NL_optimization: parameter optimization for chromosome-nuclear landmarks interactions
+
+- chr_chr_optimization: parameter optimization for chromosome-chromosome interactions