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Zhuohan1999 committed Sep 30, 2023
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simulation.py
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2 changes: 1 addition & 1 deletion tutorials/HFF_100KB/README.md
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## HFF model with nuclear landmarks at 100KB resolution

This folder provides tutorials for setting up and performing simulations of the HFF nucleusi at the 100KB resolution with the presence of various nuclear landmarks, including nuclear lamina, speckles, and nucleoli.
This folder provides tutorials for setting up and performing simulations of the HFF nucleus at the 100KB resolution with the presence of various nuclear landmarks, including nuclear lamina, speckles, and nucleoli.

- SphericalNucleus
1. This tutorial explains how to setup simulations of a spherical nucleus.
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simulation.py
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## Spherical Nucleus

This folder provides tutorials for setting up and performing simulations of the HFF nucleus at the 100KB resolution with the presence of various nuclear landmarks, including nuclear lamina, speckles, and nucleoli.


12 changes: 6 additions & 6 deletions tutorials/analysis_code/README.md
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## Analysis code

compute_contact_prob.ipynb: call and computes the contact probabilities (DamID, TSASeq, and chr-chr)
- compute_contact_prob.ipynb: call and computes the contact probabilities (DamID, TSASeq, and chr-chr)

contact_calculation: execution file compiled from Fortran code "../../openNucleome/utility/chromosome_contact_calculation.f90"
- contact_calculation: execution file compiled from Fortran code "../../openNucleome/utility/chromosome_contact_calculation.f90"

mol_info: store all the molecular information files necessary for computing contact probabilities
- mol_info: store all the molecular information files necessary for computing contact probabilities

frame_10.dcd: trajectory file example which contains 10 frames
- frame_10.dcd: trajectory file example which contains 10 frames

contact_prob: store all the chromosome-chromosome contact probabilities, the number of contacts, and the number of analyzed frames
- contact_prob: store all the chromosome-chromosome contact probabilities, the number of contacts, and the number of analyzed frames

expt_constraints_HFF_100KB.txt: experimental chromosome-chromosome contact probabilities, the first 2489 values are ideal contacts, the next 6 are compt-compt contacts, and the remaining 231 are interchromosomal contacts
- expt_constraints_HFF_100KB.txt: experimental chromosome-chromosome contact probabilities, the first 2489 values are ideal contacts, the next 6 are compt-compt contacts, and the remaining 231 are interchromosomal contacts
6 changes: 3 additions & 3 deletions tutorials/analysis_code/contact_prob/README.md
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## contact_prob

contact_prob.txt: averaged contact probabilities over different frames
- contact_prob.txt: averaged contact probabilities over different frames

nframes.txt: the number of analyzed frames
- nframes.txt: the number of analyzed frames

counter.txt: the total number of contacts
- counter.txt: the total number of contacts
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## Molecular information

DAM-ID_HFF_100KB.txt: DamID signal for HFF model at resolution of 100KB
- DAM-ID_HFF_100KB.txt: DamID signal for HFF model at resolution of 100KB

TSA-Seq_SON_HFF_100KB.txt: TSA-Seq signal for HFF model at resolution of 100KB
- TSA-Seq_SON_HFF_100KB.txt: TSA-Seq signal for HFF model at resolution of 100KB

gLengthFile.txt: The difference between each two neighboring values in the file represents the length of the chromosome
- gLengthFile.txt: The difference between each two neighboring values in the file represents the length of the chromosome

maternalIdxFile.txt: Index of each maternal chromosome
- maternalIdxFile.txt: Index of each maternal chromosome

paternalIdxFile.txt: Index of each paternal chromosome
- paternalIdxFile.txt: Index of each paternal chromosome

compartment_genome_100KB_diploid_HFF.txt: The type of each chromatin bead (1: compartment A, 2: compartment B, 3: compartment C, 4: beads around type 3)
- compartment_genome_100KB_diploid_HFF.txt: The type of each chromatin bead (1: compartment A, 2: compartment B, 3: compartment C, 4: beads around type 3)

mol_index_cell_type-HFF.txt: Index of the chromosome that each bead belongs to
- mol_index_cell_type-HFF.txt: Index of the chromosome that each bead belongs to

tad_index_genome_100KB_diploid_cell_type-HFF.txt: The first column is the index of each bead in the diploid representation and the second column is the index in the haploid representation
- tad_index_genome_100KB_diploid_cell_type-HFF.txt: The first column is the index of each bead in the diploid representation and the second column is the index in the haploid representation

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