From 874c48550c4ce2938ee0b25a71336634a237a8e0 Mon Sep 17 00:00:00 2001
From: binzhangMIT <38547734+binzhangMIT@users.noreply.github.com>
Date: Thu, 29 Feb 2024 13:18:25 -0500
Subject: [PATCH] Update README.md

---
 tutorials/optimization/chr_NL_optimization/README.md | 2 +-
 1 file changed, 1 insertion(+), 1 deletion(-)

diff --git a/tutorials/optimization/chr_NL_optimization/README.md b/tutorials/optimization/chr_NL_optimization/README.md
index ecc7588..5cf70e5 100644
--- a/tutorials/optimization/chr_NL_optimization/README.md
+++ b/tutorials/optimization/chr_NL_optimization/README.md
@@ -1,6 +1,6 @@
 ## chromosome-nuclear landmarks optimization code
 
-ChrNLOptimization.ipynb logs the process of optimizing the chromosome-nuclear landmarks interactions. The users can use the notebook OpenNucleome/tutorials/compute_contact_prob/ComputeContactProb.ipynb to get the DamID and TSA-Seq, then, use this notebook to optimize the interactions with the Adam Optimizer. The loss function is similar to the chr-chr optimization $$L = \sum_i (\left< f_i\right> - f_i^\text{exp})^2$$
+ChrNLOptimization.ipynb logs the process of optimizing interaction parameters between chromosome and nuclear landmarks. 
 
 The pipline is the same as that in the folder "../chr_chr_optimization"