Update README.md

tutorials/optimization/chr_NL_optimization/README.md

@@ -1,6 +1,6 @@
 ## chromosome-nuclear landmarks optimization code
 
-ChrNLOptimization.ipynb logs the process of optimizing the chromosome-nuclear landmarks interactions. The users can use the notebook OpenNucleome/tutorials/compute_contact_prob/ComputeContactProb.ipynb to get the DamID and TSA-Seq, then, use this notebook to optimize the interactions with the Adam Optimizer. The loss function is similar to the chr-chr optimization $$L = \sum_i (\left< f_i\right> - f_i^\text{exp})^2$$
+ChrNLOptimization.ipynb logs the process of optimizing interaction parameters between chromosome and nuclear landmarks. 
 
 The pipline is the same as that in the folder "../chr_chr_optimization"