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# Tutorials | ||
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This folder provides tutorials for the simulation and analysis with our model. | ||
This folder provides tutorials using Jupyter Notebooks for various functionality supported by the software. | ||
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- HFF_100KB: Set up and performing simulations of a human nucleus using existing parameters, with Langevin dynamics or Brownian dynamics, with default setup or customized setup, with nuclear deformation or not. | ||
- init_configs: Detailed instructions for generating, relaxing, and selecting initial configurations for MD simulations. | ||
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- compute_contact_prob: Compute the contact probablities within chromosomes and chromosome-Nuclear landmarks (DamID, TSA-Seq). | ||
- HFF_100KB: Instructions for setting up and performing MD simulations of a human nucleus using optimized parameters. Two integrators, Langevin dynamics or Brownian dynamics, can be used to simulations. The model also supports deforming the nucleus from a perfect spherical geometry. | ||
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- init_configs: Include the configuration generation, configuration relaxation, and configuration selection for the following parameter optimization and analysis. | ||
- compute_contact_prob: Instructions for computing contact probablities between chromosomes to compare with Hi-C data, and for computing chromosome-nuclear landmarks contact probabilities to compared with Lamin B DamID and SON TSA-Seq. | ||
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- optimization: Include the parameter optimization for ideal, compt-compt, inter-chromosomal interactions, and Chromosome-Speckle, Chromosome-Nucleolus interactions. | ||
- optimization: Instructions for optimizing model parameters. | ||
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- new_feature: Tutorials for how to include new features and new beads into the system | ||
- new_feature: Tutorial for expanding the software to introduce new features and components to the nucleus model. |