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joan-yanqiong authored Nov 8, 2024
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# Integrating histopathology and transcriptomics for spatial tumor microenvironment profiling in a melanoma case study

Our pipeline, SPoTLIghT, can be used to derive spatial graph-based interpretable features from H&E slides and is available as a Nextflow pipeline.
Our pipeline, SPoTLIghT, as presented in our [paper](https://www.nature.com/articles/s41698-024-00749-w), can be used to derive spatial graph-based interpretable features from H&E slides and is available as a Nextflow pipeline.

The pipeline comprises the following modules:
1. Extracting histopathological features
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2. [Extracting spatial features using SKCM cell type models](docs/examples.md)

For more information, please read [docs/README.md](docs/README.md)

## Citing SPoTLIghT

If you use SPoTLIghT, please cite our paper:

Lapuente-Santana, Ó., Kant, J. & Eduati, F. Integrating histopathology and transcriptomics for spatial tumor microenvironment profiling in a melanoma case study. npj Precis. Onc. 8, 254 (2024). https://doi.org/10.1038/s41698-024-00749-w

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