Assertion.md

Assertion

Properties

Name	Type	Description	Notes
_score	Float	indicator of the quality of the match.	[optional]
id	String		[optional]
externalId	java.util.List<String>	Optional institution specific identifier.	[optional]
uniqueKey	String	Unique identifer inclusive of version.	[optional]
hashKey	String	Static identifier agnostic of version.	[optional]
description	String	Detailed description of the assertion.	[optional]
narrative	String	A human readeable narrative describing the assertion.	[optional]
regulatoryBody	RegulatoryBodyEnum	The regulatory body that has governance over this assertion.
customer	String	The customer identifier that has governance over this assertion.
version	Integer	The assertion set version number.
regulatoryBodyApproved	Boolean	If true, this assertion's therapuetic context has regulatory approval.	[optional]
regulatoryBodyApprovedBy	String	Governing body granting approval.	[optional]
direction	DirectionEnum	Indicates whether assertion supports or does not support the therapy.	[optional]
guidelineBody	GuidelineBodyEnum	A professional committee recommendation.	[optional]
guidelineVersion	String	Release version of professional committee recommendation.	[optional]
clinicalSignificance	ClinicalSignificanceEnum	Utility of biomarker in clinical setting.	[optional]
biomarkerClass	BiomarkerClassEnum	Indicator of response to therapy	[optional]
expression	String	mathematical expression characterizing the clinical scope of the assertion.	[optional]
sources	java.util.List<AssertionSources>	The supporting evidence for this assertion.	[optional]
noTherapyAvailable	Boolean	If true, there is no therapy related to this assertion.	[optional]
therapeuticContext	java.util.List<AssertionTherapeuticContext>	The therapies associated with this assertion.	[optional]
tier	String	The tiering template specific tier associated with the therapy.	[optional]
tierExplanation	java.util.List<TierExplanation>	The explanation of how the tier was calculated.	[optional]
criteriaUnmet	java.util.List<ConceptAssociation>		[optional]
criteriaMet	java.util.List<ConceptAssociation>		[optional]
classifications	java.util.List<AssertionClassifications>		[optional]
prevalence	java.util.List<AssertionPrevalence>		[optional]
variantInfo	java.util.List<VariantInfo>	Genomic information pertaining to variant.	[optional]

Enum: RegulatoryBodyEnum

Name	Value
FDA	"FDA"
EMA	"EMA"
HCA	"HCA"
TGA	"TGA"

Enum: DirectionEnum

Name	Value
SUPPORTS	"supports"
DOES_NOT_SUPPORT	"does_not_support"

Enum: GuidelineBodyEnum

Name	Value
NCCN	"NCCN"
ASCO	"ASCO"
ESMO	"ESMO"
AJCC	"AJCC"
AMP	"AMP"
CAP	"CAP"

Enum: ClinicalSignificanceEnum

Name	Value
NO_RESPONSE	"no_response"
SENSITIVE	"sensitive"
FAVORABLE	"favorable"
UNFAVORABLE	"unfavorable"
UNKNOWN	"unknown"
RESISTANT	"resistant"
INTERMEDIATE	"intermediate"
ADVERSE_RESPONSE	"adverse_response"
PATHOGENIC	"pathogenic"
NOT_IMPLICATED	"not_implicated"
GAIN_OF_FUNCTION	"gain_of_function"
LOSS_OF_FUNCTION	"loss_of_function"

Enum: BiomarkerClassEnum

Name	Value
PREDICTIVE	"predictive"
DIAGNOSTIC	"diagnostic"
PROGNOSTIC	"prognostic"
UNKNOWN	"unknown"
PREDISPOSING	"predisposing"
FUNCTIONAL	"functional"