GitHub - ModelDBRepository/128559: Mathematical model for windup (Aguiar et al. 2010)

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Name		Name	Last commit message	Last commit date
Latest commit History 3 Commits
AMPA_DynSyn.mod		AMPA_DynSyn.mod
CaIntraCellDyn.mod		CaIntraCellDyn.mod
GABAa_DynSyn.mod		GABAa_DynSyn.mod
GABAb_DynSyn.mod		GABAb_DynSyn.mod
HH2.mod		HH2.mod
NK1_DynSyn.mod		NK1_DynSyn.mod
NMDA_DynSyn.mod		NMDA_DynSyn.mod
WDR.hoc		WDR.hoc
herreroscatter.m		herreroscatter.m
iCaAN.mod		iCaAN.mod
iCaL.mod		iCaL.mod
iKCa.mod		iKCa.mod
iNaP.mod		iNaP.mod
interneuron.hoc		interneuron.hoc
loadsynapticcurrents.m		loadsynapticcurrents.m
mGluR_DynSyn.mod		mGluR_DynSyn.mod
mosinit.hoc		mosinit.hoc
readme.html		readme.html
screenshot.jpg		screenshot.jpg
wdr-complete-model-exportsyns.hoc		wdr-complete-model-exportsyns.hoc
wdr-complete-model.hoc		wdr-complete-model.hoc
wdr-complete-model.ses		wdr-complete-model.ses
wdr_spike_times.dat		wdr_spike_times.dat

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<html><pre>This is the readme for the model associated with

Aguiar P, Sousa M, Lima D (2010) NMDA channels together with L-type
calcium currents and calcium-activated nonspecific cationic currents
are sufficient to generate windup in WDR neurons. J Neurophysiol
104:1155-66

This model is also available as a web link through the paper:

http://www.fc.up.pt/pessoas/pauloaguiar/WDRmodel.zip

You can either auto-launch the model or download the zip file, expand
compile the mod files, and run mosinit.hoc to regenerate figure 2C:

<img src="screenshot.jpg" alt="Fig. 2c" height="200" width="500">

20120330 CaIntraCellDyn.mod had it's solve method updated from euler
to derivimplicit.  For more information see:
http://www.neuron.yale.edu/phpBB/viewtopic.php?f=28&t=592
</pre></html>