diff --git a/README.md b/README.md index abfca38..82b9612 100644 --- a/README.md +++ b/README.md @@ -5,11 +5,11 @@ PyMissense create the plot and modified pdb as shown in the [AlphaMissense paper AlphaMissense allows you to identify regions in your amino acid chain that are critical for protein function. This notebook does two things: -1. It generates a plot similar to Figure 3d of the [AlphaMissense paper](https://www.science.org/doi/10.1126/science.adg7492) +1. It generates a plot similar to [Figure 3D](https://www.science.org/doi/10.1126/science.adg7492#F3) of the [AlphaMissense paper](https://www.science.org/doi/10.1126/science.adg7492) - ![Alt text](resources/img/fig3d.png) + ![Alt text](resources/img/3d.png) -2. It creates a modified PDB file where the temperature factor is replaced by the pathogencity predicted by AlphaMissense that allows you to visualize the effect with Chimerax, like Figure 3f of the paper: +2. It creates a modified PDB file where the temperature factor is replaced by the pathogencity predicted by AlphaMissense that allows you to visualize the effect with Chimerax, like [Figure 3F](https://www.science.org/doi/10.1126/science.adg7492#F3) of the paper: ![Alt text](resources/img/fig3f.png) @@ -41,7 +41,7 @@ options: You can provide the positional argumetn `--pdbpath` if you want to use an experimental PDB, otherwise it will instead download the alphafold predicted PDB. One example could be: -For example, to reproduce Figure 3D (the middle one) and the generate the PDB shown in Figure 3F do: +For example, to reproduce [Figure 3D](https://www.science.org/doi/10.1126/science.adg7492#F3) (the middle one) and the generate the PDB shown in [Figure 3F](https://www.science.org/doi/10.1126/science.adg7492#F3) do: ``` pymissense Q9UQ13 out --maxacid 200 diff --git a/resources/img/3d.png b/resources/img/3d.png new file mode 100644 index 0000000..88295e7 Binary files /dev/null and b/resources/img/3d.png differ diff --git a/resources/img/fig3d.png b/resources/img/fig3d.png deleted file mode 100644 index 14ca449..0000000 Binary files a/resources/img/fig3d.png and /dev/null differ