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The impact of COVID-19 vaccination on patients with congenital heart disease in England: a case-control study

Catriona Harrison, Simon Frain, Farideh Jalalinajafabadi, Simon G Williams, Bernard Keavney, on behalf of the CVD-COVID-UK/COVID-IMPACT Consortium

Project description

Congenital heart disease (CHD) patients were identified during the COVID-19 pandemic as a vulnerable group at increased risk of severe outcomes from Sars-CoV-2 infection. Up-to-date health data following widespread vaccination enables a reassessment of these risks in the vaccinated CHD population.

In this sub-project, we aimed to:

  1. Characterise the risks from COVID-19 to vaccinated CHD patients compared to vaccinated controls.
  2. Compare the reduction in vaccine efficacy over time between CHD cases and controls.
  3. Examine the additional risk experienced by vaccinated CHD patients with increased anatomical complexity and physiological severity.
  4. Compare the incidence of vaccine-associated complications between CHD cases and controls.

How to cite this work

Harrison C, Frain S, Jalalinajafabadi F, et alThe impact of COVID-19 vaccination on patients with congenital heart disease in England: a case-control studyHeart Published Online First: 11 October 2024. doi: https://doi.org/10.1136/heartjnl-2024-324470

Contents

Project approval

This is a sub-project of project CCU068 approved by the CVD-COVID-UK / COVID-IMPACT Approvals & Oversight Board (sub-project: CCU068_01).

License

Licensed under the Apache License, Version 2.0 (the "License"); you may not use this software except in compliance with the License. You may obtain a copy of the License at http://www.apache.org/licenses/LICENSE-2.0. Unless required by applicable law or agreed to in writing, software distributed under the License is distributed on an "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. See the License for the specific language governing permissions and limitations under the License.